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Sample records for 2-3 times weekly

  1. Building School Culture One Week at a Time

    ERIC Educational Resources Information Center

    Zoul, Jeffrey

    2010-01-01

    Use Friday Focus memos to motivate and engage your staff every week, and help create a school culture focused on the growth of students "and" teachers. Easy to understand and implement, Friday Focus memos offer an effective and efficient way to improve student learning, staff development, and school culture from within. Written by educational…

  2. Pregnancy week by week

    MedlinePlus

    ... Pregnancy > Prenatal care > Pregnancy week by week Pregnancy week by week Week by week Videos Swipe to advance Learn ... grows each week during pregnancy. Pick your week. Weeks 1-2 Conception (also called fertilization) usually happens ...

  3. Effects of 6-Times-Weekly Versus 3-Times-Weekly Hemodialysis on Depressive Symptoms and Self-reported Mental Health: Frequent Hemodialysis Network (FHN) Trials

    PubMed Central

    Unruh, Mark L.; Larive, Brett; Chertow, Glenn M; Eggers, Paul W.; Garg, Amit X.; Gassman, Jennifer; Tarallo, Maria; Finkelstein, Fredric O.; Kimmel, Paul L.

    2013-01-01

    Background Patients undergoing maintenance hemodialysis frequently exhibit poor mental health. We studied the effects of frequent in-center and nocturnal hemodialysis on depressive symptoms and self-reported mental health. Study Design 1-year randomized-controlled clinical trials. Setting & Participants Hemodialysis centers in the United States and Canada. A total of 332 patients were randomized to frequent (six times per week) as compared with conventional (three times per week) hemodialysis in the Frequent Hemodialysis Network (FHN) Daily (n=245) and Nocturnal (n=87) Trials. Intervention Daily Trial was a trial of frequent (six times per week), as compared with conventional (three times per week) in-center hemodialysis. The Nocturnal Trial assigned patients to either frequent nocturnal hemodialysis (six times per week) or conventional hemodialysis (three times per week). Outcomes Self-reported depressive symptoms and mental health. Measurements Beck Depression Inventory (BDI) and the mental health composite (MHC) score and emotional subscale of the RAND 36-Item Health Survey at baseline, 4 and 12 months. The MHC score is derived by summarizing these domains of the RAND 36-Item Health Survey: emotional, role emotional, energy/fatigue, and social functioning scales. Results In the Daily Trial, subjects randomized to frequent as compared with conventional in-center hemodialysis demonstrated no significant change over 12 months in adjusted mean BDI (−1.9 ± 0.7 vs. −0.6 ± 0.7; p=0.2), but experienced clinically significant improvements in adjusted mean MHC (3.7 ± 0.9 vs. 0.2 ± 1.0; P<0.01) and the emotional subscale (5.2 ± 1.6 vs. −0.3 ± 1.7; p=0.01). In the Nocturnal Trial, there were no significant changes among subjects randomized to nocturnal as compared with conventional hemodialysis on the same metrics. Limitations The trial interventions were not blinded. Conclusions Frequent in-center hemodialysis, as compared with conventional in

  4. Weekly Trends in Preschoolers’ Physical Activity and Sedentary Time in Childcare

    PubMed Central

    Vanderloo, Leigh M.; Tucker, Patricia

    2015-01-01

    This study sought to examine how the physical activity levels and sedentary time of preschoolers attending center-based childcare varied across the week. Sex differences were also explored. Participants (n = 101) wore Actical™ accelerometers (15 s epoch) for five consecutive days during childcare hours only. A multivariate repeated measures analysis of variance was used to evaluate levels of sedentary, light, and moderate-to-vigorous (MVPA) physical activity across the five weekdays. Total physical activity (TPA) was analyzed separately in a univariate repeated measures ANOVA. Sex was entered as an additional between-subjects factor. Levels of sedentary time, LPA, and TPA across the week were found to be statistically significant, and can best be described by quadratic effects. Participants’ activity levels and sedentary time typically peaked mid-week. Levels of physical activity and sedentary time were not found to significantly differ based on sex. Childcare centers may benefit from the introduction and/or modification of active play-based programming and curricula, particularly at the start and end of the week where preschoolers’ activity levels tend to be lower. Additional investigations are required to confirm these findings. PMID:25809506

  5. Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts B-cell lymphopoiesis and exacerbates autoimmune disease in 24-week-old SNF1 mice.

    PubMed

    Mustafa, Amjad; Holladay, Steven D; Witonsky, Sharon; Zimmerman, Kurt; Reilly, Christopher M; Sponenberg, D Phillip; Weinstein, Danielle A; Karpuzoglu, Ebru; Gogal, Robert M

    2009-11-01

    Female SNF(1) hybrid mice spontaneously develop an immune complex-mediated glomerulonephritis as early as 24 weeks of age, whereas the disease onset in males is much slower. Further, a rise in concentration of glomerulus-specific autoantibodies via autoreactive B cells is critical to progression of the disease in this strain. Environmental factors contributing to the onset or degree of such autoimmunity are of interest yet poorly understood. In the present study, time-pregnant SWR x NZB dams (10/treatment) were gavaged on gestational 12 with 40 or 80 mg/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and the SNF(1) offspring were evaluated at 24 weeks of age. Bone marrow B220(low)CD24(-)AA4.1(+) committed B lineage progenitors were increased in female offspring by TCDD, however, committed progenitors and pro-B cells were decreased in males. Splenic marginal zone B cells (CD21(hi)CD24(low-int)) were decreased and follicular B cells (CD21(int)CD24(low)) were increased across sex by prenatal TCDD, whereas transitional-2 B cells (CD21(int)CD24(hi)) and (CD23(low-int) CD1(low-int)) were decreased in males only. Antibodies to double-stranded DNA were significantly increased across sex by TCDD. Anti-IgG and anti-C3 immune complex renal deposition was visibly worsened in females, and present in TCDD-treated males. These data suggest that developmental exposure to TCDD permanently and differentially alters humoral immune function by sex, and exacerbates a type III hypersensitivity lupus-like autoimmune disease in genetically predisposed mice.

  6. Time course of natural heat acclimatization in well-trained cyclists during a 2-week training camp in the heat.

    PubMed

    Karlsen, A; Nybo, L; Nørgaard, S J; Jensen, M V; Bonne, T; Racinais, S

    2015-06-01

    The aim of this study was to determine the time course of physiological adaptations and their relationship with performance improvements during 2 weeks of heat acclimatization. Nine trained cyclists completed 2 weeks of training in naturally hot environment (34 ± 3 °C; 18 ± 5% relative humidity). On days 1, 6, and 13, they performed standardized heat response tests (HRT-1, 2, 3), and 43.4-km time trials in the heat (TTH-1, 2, 3) were completed on days 2, 7, and 14. Within the first 5-6 days, sweat sodium concentration decreased from 75 ± 22 mmol/L to 52 ± 24 mmol/L, sweat rate increased (+20 ± 15%), and resting hematocrit decreased (-5.6 ± 5.4%), with no further changes during the remaining period. In contrast, power output during TTHs gradually improved from TTH-1 to TTH-2 (+11 ± 8%), and from TTH-2 to TTH-3 (+5 ± 4%). Individual improvements in performance from TTH-1 to TTH-2 correlated with individual changes in hematocrit (assessed after the corresponding HRT; r = -0.79, P < 0.05), however, were not related to changes in performance from TTH-2 to TTH-3. In trained athletes, sudomotor and hematological adaptations occurred within 5-6 days of training, whereas the additional improvement in performance after the entire acclimatization period did not relate to changes in these parameters.

  7. Weekly Solutions of Time-Variable Gravity from 1993 to 2010

    NASA Technical Reports Server (NTRS)

    Lemoine, F.; Chinn, D.; Le Bail, K.; Zelensky, N.; Melachroinos, S.; Beall, J.

    2011-01-01

    The GRACE mission has been highly successful in determining the time-variable gravity field of the Earth, producing monthly or even more frequent solutions (cf. 10-day) solutions using both spherical harmonics and mascons. However the GRACE time series only commences in 2002 - 2003 and a gap of several years may occur in the series before a GRACE follow-on satellite is launched. Satellites tracked by SLR and DORIS have also been used to study time variations in the Earth's gravitational field. These include (most recently) the solutions of Cox and Chao (2002), Cheng et al. (2004, 2007) and Lemoine et al. (2007). In this paper we discuss the development of a new time series of low degree spherical harmonic fields based on the available SLR, DORIS and GPS data. We develop simultaneous solutions for both the geocenter and the low degree harmonics up to 5x5. The solutions integrate data from SLR geodetic satellites (e.g., Lageos1, Lageos2, Starlette, Stella, Ajisai, Larets, Westpac), altimetry satellites (TOPEX/Poseidon, Envisat, Jason-1, Jason-2), and satellites tracked solely by DORIS (e.g. SPOT2-5). We discuss some pertinent aspects of the satellite-specific modeling. We include altimeter crossovers in the weekly solutions where feasible and time permits. The resulting geocenter time series is compared with geophysical model predictions and other independently-derived solutions. Over the GRACE time period the fidelity and consistency with the GRACE solutions are presented.

  8. Investigation of Noises in GPS Time Series: Case Study on Epn Weekly Solutions

    NASA Astrophysics Data System (ADS)

    Klos, Anna; Bogusz, Janusz; Figurski, Mariusz; Kosek, Wieslaw; Gruszczynski, Maciej

    2014-05-01

    The noises in GPS time series are stated to be described the best by the combination of white (Gaussian) and power-law processes. They are mainly the effect of mismodelled satellite orbits, Earth orientation parameters, atmospheric effects, antennae phase centre effects, or of monument instability. Due to the fact, that velocities of permanent stations define the kinematic reference frame, they have to fulfil the requirement of being stable at 0.1 mm/yr. The previously performed researches showed, that the wrong assumption of noise model leads to the underestimation of velocities and their uncertainties from 2 up to even 11, especially in the Up direction. This presentation focuses on more than 200 EPN (EUREF Permanent Network) stations from the area of Europe with various monument types (concrete pillars, buildings, metal masts, with or without domes, placed on the ground or on the rock) and coordinates of weekly changes (GPS weeks 0834-1459). The topocentric components (North, East, Up) in ITRF2005 which come from the EPN Re-Processing made by the Military University of Technology Local Analysis Centre (MUT LAC) were processed with Maximum Likelihood Estimation (MLE) using CATS software. We have assumed the existence of few combinations of noise models (these are: white, flicker and random walk noise with integer spectral indices and power-law noise models with fractional spectral indices) and investigated which of them EPN weekly time series are likely to follow. The results show, that noises in GPS time series are described the best by the combination of white and flicker noise model. It is strictly related to the so-called common mode error (CME) that is spatially correlated error being one of the dominant error source in GPS solutions. We have assumed CME as spatially uniform, what was a good approximation for stations located hundreds of kilometres one to another. Its removal with spatial filtering reduces the amplitudes of white and flicker noise by a

  9. Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex

    PubMed Central

    2017-01-01

    Recent studies have shown that ocular dominance plasticity in layer 2/3 of the visual cortex exhibits a form of homeostatic plasticity that is related to synaptic scaling and depends on TNFα. In this study, we tested whether a similar form of plasticity was present in layer 2/3 of the barrel cortex and, therefore, whether the mechanism was likely to be a general property of cortical neurons. We found that whisker deprivation could induce homeostatic plasticity in layer 2/3 of barrel cortex, but not in a mouse strain lacking synaptic scaling. The time-course of homeostatic plasticity in layer 2/3 was similar to that of L5 regular spiking (RS) neurons (L5RS), but slower than that of L5 intrinsic bursting (IB) neurons (L5IB). In layer 5, the strength of evoked whisker responses and ex vivo miniature excitatory post-synaptic currents (mEPSCs) amplitudes showed an identical time-course for homeostatic plasticity, implying that plasticity at excitatory synapses contacting layer 5 neurons is sufficient to explain the changes in evoked responses. Spontaneous firing rate also showed homeostatic behaviour for L5IB cells, but was absent for L5RS cells over the time-course studied. Spontaneous firing rate homeostasis was found to be independent of evoked response homeostasis suggesting that the two depend on different mechanisms. This article is part of the themed issue ‘Integrating Hebbian and homeostatic plasticity’. PMID:28093546

  10. Time-course and mechanisms of homeostatic plasticity in layers 2/3 and 5 of the barrel cortex.

    PubMed

    Glazewski, Stanislaw; Greenhill, Stuart; Fox, Kevin

    2017-03-05

    Recent studies have shown that ocular dominance plasticity in layer 2/3 of the visual cortex exhibits a form of homeostatic plasticity that is related to synaptic scaling and depends on TNFα. In this study, we tested whether a similar form of plasticity was present in layer 2/3 of the barrel cortex and, therefore, whether the mechanism was likely to be a general property of cortical neurons. We found that whisker deprivation could induce homeostatic plasticity in layer 2/3 of barrel cortex, but not in a mouse strain lacking synaptic scaling. The time-course of homeostatic plasticity in layer 2/3 was similar to that of L5 regular spiking (RS) neurons (L5RS), but slower than that of L5 intrinsic bursting (IB) neurons (L5IB). In layer 5, the strength of evoked whisker responses and ex vivo miniature excitatory post-synaptic currents (mEPSCs) amplitudes showed an identical time-course for homeostatic plasticity, implying that plasticity at excitatory synapses contacting layer 5 neurons is sufficient to explain the changes in evoked responses. Spontaneous firing rate also showed homeostatic behaviour for L5IB cells, but was absent for L5RS cells over the time-course studied. Spontaneous firing rate homeostasis was found to be independent of evoked response homeostasis suggesting that the two depend on different mechanisms.This article is part of the themed issue 'Integrating Hebbian and homeostatic plasticity'.

  11. US stock market efficiency over weekly, monthly, quarterly and yearly time scales

    NASA Astrophysics Data System (ADS)

    Rodriguez, E.; Aguilar-Cornejo, M.; Femat, R.; Alvarez-Ramirez, J.

    2014-11-01

    In financial markets, the weak form of the efficient market hypothesis implies that price returns are serially uncorrelated sequences. In other words, prices should follow a random walk behavior. Recent developments in evolutionary economic theory (Lo, 2004) have tailored the concept of adaptive market hypothesis (AMH) by proposing that market efficiency is not an all-or-none concept, but rather market efficiency is a characteristic that varies continuously over time and across markets. Within the AMH framework, this work considers the Dow Jones Index Average (DJIA) for studying the deviations from the random walk behavior over time. It is found that the market efficiency also varies over different time scales, from weeks to years. The well-known detrended fluctuation analysis was used for the characterization of the serial correlations of the return sequences. The results from the empirical showed that interday and intraday returns are more serially correlated than overnight returns. Also, some insights in the presence of business cycles (e.g., Juglar and Kuznets) are provided in terms of time variations of the scaling exponent.

  12. Quiet-time magnetospheric field depression at 2.3 to 3.6 R sub E

    NASA Technical Reports Server (NTRS)

    Sugiura, M.

    1972-01-01

    Fluxgate magnetometer data obtained by OGO-5 near perigee were used to establish the existence of large field depressions in the magnetosphere under conditions of varying degree of disturbance at distances ranging from 2.3 to 3.6 R sub E at all local times. The results also provide the average delta B at these distances when Dst, as being derived at present, is zero.

  13. Weekly cycles in peak time temperatures and urban heat island intensity

    NASA Astrophysics Data System (ADS)

    Earl, Nick; Simmonds, Ian; Tapper, Nigel

    2016-07-01

    Regular diurnal and weekly cycles (WCs) in temperature provide valuable insights into the consequences of anthropogenic activity on the urban environment. Different locations experience a range of identified WCs and have very different structures. Two important sources of urban heat are those associated with the effect of large urban structures on the radiation budget and energy storage and those from the heat generated as a consequence of anthropogenic activity. The former forcing will remain relatively constant, but a WC will appear in the latter. WCs for specific times of day and the urban heat island (UHI) have not been analysed heretofore. We use three-hourly surface (2 m) temperature data to analyse the WCs of seven major Australian cities at different times of day and to determine to what extent one of our major city’s (Melbourne) UHI exhibits a WC. We show that the WC of temperature in major cities differs according to the time of day and that the UHI intensity of Melbourne is affected on a WC. This provides crucial information that can contribute toward the push for healthier urban environments in the face of a more extreme climate.

  14. 2-weekly docetaxel: issues for clinical practice

    PubMed Central

    Massari, F; Maines, F; Bria, E; Galligioni, E; Caffo, O; Tortora, G

    2015-01-01

    In the phase III trial comparing 2 docetaxel schedules (3-weekly versus 2-weekly) as first-line chemotherapy for CRPC, recently published in The Lancet Oncology, fewer serious adverse events, particularly hematologic toxicities, and longer times on treatment, in favor of the 2-weekly regimen are reported.1,2,3 PMID:25456569

  15. [Effect of 4 weeks of training on the limit time at VO2 max].

    PubMed

    Heubert, Richard; Bocquet, Valéry; Koralsztein, Jean Pierre; Billat, Véronique

    2003-10-01

    The purpose of this study was to examine the effect of 4 weeks training in running on the time spent at VO2max (tlim VO2max). Eight athletes carried out, before and after an aerobic training, an incremental and five exhaustive tests at 90, 95, 100, 115% vVO2max and at the critical power at VO2max (CV'; slope of the linear relation between the tlim VO2max and the distance limit at VO2max). This training did not significantly improve VO2max (p = 0.17) or tlim VO2max (p = 0.72). However, the "tlim VO2max-intensity" curve was shifted toward the right, meaning that the athlete had to run at a higher intensity after training to obtain the same tlim VO2max. Tlim VO2max at CV' before training was significantly higher than tlim VO2max at 90, 95, 100, and 115% vVO2max (p < 0.05). This training increased CV' in absolute value (13.9 +/- 1.3 vs. 14.9 +/- 1.2 km.h-1, p < 0.05; n = 6) but not in relative value (86 +/- 4 vs. 86 +/- 5% vVO2max; p = 0.9). In conclusion, in spite of the shift of the "tlim VO2max-intensity" curve, tlim VO2max was not significantly increased by this training. Furthermore, CV' allowed subjects to spend the longest time of exercise at VO2max during a continuous exercise with constant speed, but CV', expressed in % vVO2max, did not improve with this training.

  16. BYU Holds Annual Indian Week: "A Positive Time To Be Indian"

    ERIC Educational Resources Information Center

    American Indian Education, 1976

    1976-01-01

    Attended by nearly 500 persons, Brigham Young University's BYU annual Indian Week featured Morris Thompson, Bureau of Indian Affairs Commission; Chief Dan George, motion picture star; Deana Jo Harragarra, Miss Indian America XXII; and John Maestas, BYU, who spoke of the need for Indian teachers. (JC)

  17. Do Street Robbery Location Choices Vary Over Time of Day or Day of Week? A Test in Chicago

    PubMed Central

    Ruiter, Stijn; Block, Richard

    2016-01-01

    Objectives: This article examines the hypothesis that in street robbery location choices, the importance of location attributes is conditional on the time of day and on the day of the week. Method: The hypothesis is assessed by estimating and comparing separate discrete location choice models for each two-hour time block of the day and for each day of the week. The spatial units of analysis are census blocks. Their relevant attributes include presence of various legal and illegal cash economies, presence of high schools, measures of accessibility, and distance from the offender’s home. Results: The hypothesis is strongly rejected because for almost all census block attributes, their importance hardly depends on time of day or day of week. Only the effect of high schools in census blocks follows expectations, as its effect is only demonstrated at the times and on the days that schools are open. Conclusions: The results suggest that street robbers’ location choices are not as strongly driven by spatial variations in immediate opportunities as has been suggested in previous studies. Rather, street robbers seem to perpetrate in the environs of cash economies and transit hubs most of the time irrespective of how many potential victims are around. PMID:28232756

  18. Variation in Suicide Occurrence by Time of Day, Day of the Week, Month, and Lunar Phase.

    ERIC Educational Resources Information Center

    Maldonado, George; Kraus, Jess F.

    1991-01-01

    Examined 4,190 suicides among residents of a particular county from 1925 to 1983. Suicide occurrence varied substantially by time of day, and, for recent years of study, suicides occurred most frequently on Monday. Variation by month followed no consistent pattern by gender, age, years of study, or combination of factors. Suicide occurrence did…

  19. One-week time course of the effects of Mulligan's Mobilisation with Movement and taping in painful shoulders.

    PubMed

    Teys, Pamela; Bisset, Leanne; Collins, Natalie; Coombes, Brooke; Vicenzino, Bill

    2013-10-01

    Previous research suggests that Mulligan's Mobilisation-with-Movement (MWM) technique for the shoulder produces an immediate improvement in movement and pain. The aims of this study were to investigate the time course of the effects of a single MWM technique and to ascertain the effects of adding tape following MWM in people with shoulder pain. Twenty-five participants (15 males, 10 females), who responded positively to an initial application of MWM, were randomly assigned to MWM or MWM-with-Tape. Range of movement (ROM), pressure pain threshold (PPT) and current pain severity (PVAS) were measured pre- and post-intervention, 30-min, 24-h and one week follow-up. Following a one-week washout period, participants were crossed over to receive a single session of the opposite intervention with follow-up measures repeated. ROM significantly improved with MWM-with-Tape and was sustained over one week follow-up (p < 0.001; 18.8°, 95% confidence intervals (CI) 7.3-30.4), and in PVAS up to 30-min follow-up (38.4 mm, 95% CI 20.6-56.1 mm). MWM demonstrated an improvement in ROM (11.8°, 95% CI 1.9-21.7) and PVAS (40.4 mm, 95% CI 27.8-53.0 mm), but only up to 30-min follow-up. There was no significant improvement in PPT for either intervention at any time point. MWM-with-Tape significantly improved ROM over the one-week follow-up compared to MWM alone (15.9°, 95% CI 7.4-24.4). Both MWM and MWM-with-Tape provide a short-lasting improvement in pain and ROM, and MWM-with-Tape also provides a sustained improvement in ROM to one-week follow-up, which is superior to MWM alone.

  20. Effect of Eight Weekly Aerobic Training Program on Auditory Reaction Time and MaxVO[subscript 2] in Visual Impairments

    ERIC Educational Resources Information Center

    Taskin, Cengiz

    2016-01-01

    The aim of study was to examine the effect of eight weekly aerobic exercises on auditory reaction time and MaxVO[subscript 2] in visual impairments. Forty visual impairment children that have blind 3 classification from the Turkey, experimental group; (age = 15.60 ± 1.10 years; height = 164.15 ± 4.88 cm; weight = 66.60 ± 4.77 kg) for twenty…

  1. Osteocyte density in the peri-implant bone of implants retrieved after different time periods (4 weeks to 27 years).

    PubMed

    Piattelli, Adriano; Artese, Luciano; Penitente, Enrico; Iaculli, Flavia; Degidi, Marco; Mangano, Carlo; Shibli, Jamil Awad; Coelho, Paulo G; Perrotti, Vittoria; Iezzi, Giovanna

    2014-02-01

    Bone tissue is characterized by a constant turnover in response to mechanical stimuli, and osteocytes play an essential role in bone mechanical adaptation. However, little to no information has been published regarding osteocyte density as a function of implantation time in vivo. The aim of this retrospective histological study was to evaluate the osteocyte density of the peri-implant bone in implants retrieved because of different reasons in a time period from 4 weeks to 27 years. A total of 18 samples were included in the present study. Specimens were divided into 3 groups depending on the loading history of the implants: loading between 4 weeks and 7 months (group 1); loading between 1 and 5 years (group 2); loading between 14 and 27 years (group 3). All the samples were histologically evaluated and osteocyte density was obtained using the ratio of the number of osteocytes to the bone-area (mm(2) ). The osteocyte density values significantly increased in the Group 2 (1-5 years) compared with Group 1 (4 weeks-7 months), and significantly decreased in the Group 3 (14-27 years) compared to Group 2. No significant differences were detected between Group 1 and Group 3. The decrease in osteocyte density observed in samples that were in vivo for long periods of time under loading is possibly because of the fact that once the bone structure is well aligned and biomechanically competent, a lower number of osteocytes are necessary to keep the tissue homeostasis under loading.

  2. The effects of weekly exercise time on VO2max and resting metabolic rate in normal adults

    PubMed Central

    Gim, Mi-Na; Choi, Jung-Hyun

    2016-01-01

    [Purpose] The present study examined the effect of individual weekly exercise time on resting metabolic rate and VO2max (maximal oxygen uptake), which are important components of individual health indexes. [Subjects and Methods] Thirty healthy adults participated in this study. Questionnaires were used to divide the participants into groups based on average weekly walking. Resting metabolic rate was measured using a respiratory gas analyzer. Graded exercise tests were conducted using a treadmill, and the modified Bruce protocol was used as an exercise test method. [Results] VO2max, anaerobic threshold, and resting metabolic rate were significantly different among the groups. [Conclusion] Average weekly exercise time affected VO2max, resting metabolic rate, and anaerobic threshold, all of which are indicators of individual physical ability and health. These values increased as the individual amount of exercise increased. In addition, VO2max, resting metabolic rate, and anaerobic threshold were found to be closely correlated. These findings were consistent with the results of similar previous studies. PMID:27190483

  3. The effects of weekly exercise time on VO2max and resting metabolic rate in normal adults.

    PubMed

    Gim, Mi-Na; Choi, Jung-Hyun

    2016-04-01

    [Purpose] The present study examined the effect of individual weekly exercise time on resting metabolic rate and VO2max (maximal oxygen uptake), which are important components of individual health indexes. [Subjects and Methods] Thirty healthy adults participated in this study. Questionnaires were used to divide the participants into groups based on average weekly walking. Resting metabolic rate was measured using a respiratory gas analyzer. Graded exercise tests were conducted using a treadmill, and the modified Bruce protocol was used as an exercise test method. [Results] VO2max, anaerobic threshold, and resting metabolic rate were significantly different among the groups. [Conclusion] Average weekly exercise time affected VO2max, resting metabolic rate, and anaerobic threshold, all of which are indicators of individual physical ability and health. These values increased as the individual amount of exercise increased. In addition, VO2max, resting metabolic rate, and anaerobic threshold were found to be closely correlated. These findings were consistent with the results of similar previous studies.

  4. Clinical patterns in extremely preterm (22 to 24 weeks of gestation) infants in relation to survival time and prognosis.

    PubMed

    Iijima, Shigeo; Arai, Hiroko; Ozawa, Yuri; Kawase, Yasuhiro; Uga, Naoki

    2009-06-01

    We investigated time-related predictors of death or neurological sequelae in extremely preterm infants (EPI) born at 22 to 24 weeks' gestation by categorizing clinical patterns according to their survival time and morbidity. Data on 113 infants born at 22 to 24 weeks' gestation from January 1991 through April 2006 were analyzed by a case-control approach. Cesarean section, Apgar score or= 24 hours, pulmonary hemorrhage and intraventricular hemorrhage (IVH) were significantly associated with death by day 6. Among those surviving >or= 7 days, sepsis and severe IVH were significantly associated with death. Assessment of survivors at a minimum follow-up period of 2 years revealed that protracted mechanical ventilation was significantly associated with a poor neurological outcome. There are various characteristic key events in relation to the outcome at different ages of life in EPI born at 22 to 24 weeks' gestation. Clinicians and parents should discuss management options for the infant on the basis of these findings.

  5. Options in Education. Program Transcripts of a Weekly Series Broadcast by Member Stations of National Public Radio. Program #92-#96. Portrait of American Adolescence, Part 1, 2, 3, 4, and 5.

    ERIC Educational Resources Information Center

    National Public Radio, Washington, DC.

    These five booklets present the program transcripts of a weekly series broadcast by member stations of National Public Radio. A wide variety of participants express their views on various aspects of the adolescent experience. Kenneth Keniston, Urie Bronfenbrenner and Margaret Mead are among those participating as well as teenagers themselves. The…

  6. Accuracy of sea level predictions with lead time of one week: a comparison between Prognocean and MyOcean

    NASA Astrophysics Data System (ADS)

    Swierczynska, Malgorzata; Mizinski, Bartlomiej; Niedzielski, Tomasz

    2015-04-01

    There exist several systems which produce sea level forecasts in real time, with lead times ranging from hours to two weeks in the future. One of the recently developed solutions is Prognocean, the system that has been built and implemented at the University of Wroclaw, Poland. Its main feature is that it uses simple time series models to predict sea level anomaly maps, and does it for lead times ranging from 1 to 14 days with daily update. The empirical data-based models are fitted in real time both to individual grids (polynomial-harmonic model, polynomial-harmonic model combined with autoregressive model, polynomial-harmonic model combined with threshold autoregressive model) and to numerous grids forming a spatial latitude x longitude window of 3˚ x 5˚ (polynomial-harmonic model combined with multivariate autoregressive model). Although their simplicity, the approaches have already been shown to produce sea level anomaly predictions of reasonable accuracy. However, none of the analyses targeted at the comparative study which would present the skills of the Prognocean system against a background of the performance of other systems that use physically-based models. This study aims to fill this gap by comparing Prognocean-based predictions for one week into the future with the corresponding prognoses calculated by MyOcean. The reader is provided with the objectively-calculated set of statistics, presented as maps, which describes prediction errors (mean absolute error, root mean square error, index of agreement) and prediction skills (prediction efficiency, coefficient of determination) of the two systems. The exercise enables to compare the skills of the approaches, and the gridwise comparison allows one to identify areas of superior performance of each system.

  7. Driving under the influence of alcohol in the Netherlands by time of day and day of the week.

    PubMed

    Houwing, Sjoerd; Stipdonk, Henk

    2014-11-01

    The purpose of this study is to provide an overview of the variation in the prevalence of alcohol in everyday traffic in the Netherlands during all days of the week and all times of day. Breath tests were taken from randomly selected car drivers and drivers of small vans in six police regions in the Netherlands between January 2007 and August 2009. A total of 28,057 drivers were included in the study. The prevalence of driving under the influence of alcohol was highest during night-time hours of weekend days. Large proportions of sampled drivers under the influence of alcohol were also found during day-time hours on weekend days, especially early in the morning and early in the evening. Furthermore, a small proportion of sampled drivers under the influence of alcohol was found during morning traffic on Monday and Friday mornings. The results of this study indicate that drink driving is not only limited to night-time hours and that prevalence of drink driving is also high during evening hours from Wednesday to Sunday. In addition to these time periods, breath testing activities may also be effective from a police enforcement perspective on Monday, Friday, and Saturday mornings between 06.00h and 08.00h and on Sunday mornings until 10.00h.

  8. High resolution, week-long, locomotion time series from Japanese quail in a home-box environment.

    PubMed

    Guzmán, Diego A; Pellegrini, Stefania; Flesia, Ana G; Aon, Miguel A; Marin, Raúl H; Kembro, Jackelyn M

    2016-06-07

    Temporal and spatial patterns of locomotion reflect both resting periods and the movement from one place to another to satisfy physiological and behavioural needs. Locomotion is studied in diverse areas of biology such as chronobiology and physiology, as well as in biomathematics. Herein, the locomotion of 24 visually-isolated Japanese quails in their home-box environment was recorded continuously over a 6.5 days at a 0.5 s sampling rate. Three time series are presented for each bird: (1) locomotor activity, (2) distance ambulated, and (3) zone of the box where the bird is located. These high resolution, week-long, time series consisting of 1.07×10(6) data points represent, to our knowledge, a unique data set in animal behavior, and are publically available on FigShare. The data obtained can be used for analyzing dynamic changes of daily or several day locomotion patterns, or for comparison with existing or future data sets or mathematical models across different taxa.

  9. High resolution, week-long, locomotion time series from Japanese quail in a home-box environment

    PubMed Central

    Guzmán, Diego A.; Pellegrini, Stefania; Flesia, Ana G.; Aon, Miguel A.; Marin, Raúl H.; Kembro, Jackelyn M.

    2016-01-01

    Temporal and spatial patterns of locomotion reflect both resting periods and the movement from one place to another to satisfy physiological and behavioural needs. Locomotion is studied in diverse areas of biology such as chronobiology and physiology, as well as in biomathematics. Herein, the locomotion of 24 visually-isolated Japanese quails in their home-box environment was recorded continuously over a 6.5 days at a 0.5 s sampling rate. Three time series are presented for each bird: (1) locomotor activity, (2) distance ambulated, and (3) zone of the box where the bird is located. These high resolution, week-long, time series consisting of 1.07×106 data points represent, to our knowledge, a unique data set in animal behavior, and are publically available on FigShare. The data obtained can be used for analyzing dynamic changes of daily or several day locomotion patterns, or for comparison with existing or future data sets or mathematical models across different taxa. PMID:27271772

  10. Differences in parenting stress between married and single first time mothers at six to eight weeks after birth.

    PubMed

    Copeland, Debra; Harbaugh, Bonnie Lee

    2005-01-01

    Parenting stress has been shown to affect relationships between mothers and their infants. Single mothers may experience more parenting stress due to exposure to stressors that are unique to their environment. The purpose of this secondary analysis was to determine the differences between married and single first-time mothers on the Parenting Stress Index/Short Form (PSI/SF Abidin, 1995). A convenience sample of 22 single and 52 married first-time mothers were recruited from postpartum units in two large metropolitan hospitals in the southeastern United States. During hospitalization, participants completed a demographic sheet and at six weeks postpartum, were mailed the PSI/SF. T-tests were assessed for differences between mean scores. Study findings indicate significant differences between single and married first-time mothers on the Parental Distress subscale (t = -3.468, p = .001), the Difficult Child subscale (t = -2.032, p = .046), and Defensive Responding subscale (t = -3.720, p = .000), with single mothers consistently scoring higher than married mothers; however, there was not a significant statistical difference between mothers on the Parent-Child Dysfunctional Interaction subscale (t = -1.290, p = .201). Overall, single mothers scored higher on the Total Parenting Stress scores of the PSI/SF than married mothers (t = -2.858, p = .005), suggesting that single women experience more stress as a new mother than married new mothers. It is important to understand the specific stressors of new, single mothers and to develop nursing interventions that decrease parenting stress in single mothers.

  11. The Time Factor in Mandarin Language Learning: The Four-Week Intensive versus the Regular High School Semester

    ERIC Educational Resources Information Center

    Xu, Xiaoqiu; Padilla, Amado M.; Silva, Duarte

    2014-01-01

    This study compared two groups of high school students in their learning of a third-year Mandarin level 3 class under two conditions: an intensive four-week (85.5 hours) summer program and a 22-week (88 hours) regular semester program. Students in both conditions had been classmates through four semesters of Mandarin instruction and had similar…

  12. A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice

    PubMed Central

    Remmelink, Esther; Chau, Uyen; Smit, August B.; Verhage, Matthijs; Loos, Maarten

    2017-01-01

    Many psychiatric disorders emerge during adolescence. The study of executive functions in animal models of these disorders critically requires short-duration tasks measuring these functions before the animal ages. Here, a novel 5-choice serial reaction time task (5-CSRTT) protocol is presented, to measure attention and impulsivity within one week, without scheduled food deprivation and with little animal handling. Mice were allowed 24-h/day task access from their home-cage, during which they could self-pace task progression and earn unlimited food rewards depending on task performance. Manipulation of task parameters in this self-paced 5-CSRTT protocol (SP-5C) affected attentional performance and impulsivity to a similar extent as previously observed in the 5-CSRTT. Task activity followed intrinsic circadian rhythm, distinctive for the SP-5C protocol, with task performance stable over the day. The sensitivity of the SP-5C protocol to detect strain differences between C57BL/6J, DBA/2 J, BXD16 and BXD62 mice was demonstrated as well as its suitability for testing adolescent mice. Acute administration of the muscarinic acetylcholine receptor antagonist scopolamine impaired attentional performance, providing initial pharmacological validation of the task. The SP-5C substantially shortens the assessment of impulsivity and attention, increases test efficiency and enables the assessment of adolescent mouse models of psychiatric disorders. PMID:28198416

  13. A one-week 5-choice serial reaction time task to measure impulsivity and attention in adult and adolescent mice.

    PubMed

    Remmelink, Esther; Chau, Uyen; Smit, August B; Verhage, Matthijs; Loos, Maarten

    2017-02-15

    Many psychiatric disorders emerge during adolescence. The study of executive functions in animal models of these disorders critically requires short-duration tasks measuring these functions before the animal ages. Here, a novel 5-choice serial reaction time task (5-CSRTT) protocol is presented, to measure attention and impulsivity within one week, without scheduled food deprivation and with little animal handling. Mice were allowed 24-h/day task access from their home-cage, during which they could self-pace task progression and earn unlimited food rewards depending on task performance. Manipulation of task parameters in this self-paced 5-CSRTT protocol (SP-5C) affected attentional performance and impulsivity to a similar extent as previously observed in the 5-CSRTT. Task activity followed intrinsic circadian rhythm, distinctive for the SP-5C protocol, with task performance stable over the day. The sensitivity of the SP-5C protocol to detect strain differences between C57BL/6J, DBA/2 J, BXD16 and BXD62 mice was demonstrated as well as its suitability for testing adolescent mice. Acute administration of the muscarinic acetylcholine receptor antagonist scopolamine impaired attentional performance, providing initial pharmacological validation of the task. The SP-5C substantially shortens the assessment of impulsivity and attention, increases test efficiency and enables the assessment of adolescent mouse models of psychiatric disorders.

  14. The timing of compositionally-zoned magma reservoirs and mafic 'priming' weeks before the 1912 Novarupta-Katmai rhyolite eruption

    USGS Publications Warehouse

    Singer, Brad S.; Costa, Fidel; Herrin, Jason S.; Hildreth, Wes; Fierstein, Judith

    2016-01-01

    The June 6, 1912 eruption of more than 13 km3 of dense rock equivalent (DRE) magma at Novarupta vent, Alaska was the largest of the 20th century. It ejected >7 km3 of rhyolite, ~1.3 km3 of andesite and ~4.6 km3 of dacite. Early ideas about the origin of pyroclastic flows and magmatic differentiation (e.g., compositional zonation of reservoirs) were shaped by this eruption. Despite being well studied, the timing of events that led to the chemically and mineralogically zoned magma reservoir remain poorly known. Here we provide new insights using the textures and chemical compositions of plagioclase and orthopyroxene crystals and by reevaluating previous U-Th isotope data. Compositional zoning of the magma reservoir likely developed a few thousand years before the eruption by several additions of mafic magma below an extant silicic reservoir. Melt compositions calculated from Sr contents in plagioclase fill the compositional gap between 68 and 76% SiO2 in whole pumice clasts, consistent with uninterrupted crystal growth from a continuum of liquids. Thus, our findings support a general model in which large volumes of crystal-poor rhyolite are related to intermediate magmas through gradual separation of melt from crystal-rich mush. The rhyolite is incubated by, but not mixed with, episodic recharge pulses of mafic magma that interact thermochemically with the mush and intermediate magmas. Hot, Mg-, Ca-, and Al-rich mafic magma intruded into, and mixed with, deeper parts of the reservoir (andesite and dacite) multiple times. Modeling the relaxation of the Fe-Mg concentrations in orthopyroxene and Mg in plagioclase rims indicates that the final recharge event occurred just weeks prior to the eruption. Rapid addition of mass, volatiles, and heat from the recharge magma, perhaps aided by partial melting of cumulate mush below the andesite and dacite, pressurized the reservoir and likely propelled a ~10 km lateral dike that allowed the overlying rhyolite to reach the surface.

  15. ISS Update: Final Week for Long Time Flight Director Paul Dye – 01.11.13

    NASA Video Gallery

    Public Affairs Officer Dan Huot sits down with Flight Director Paul Dye in the Station Flight Control Room. In his final week as a flight director, Dye discusses his experiences from the beginning ...

  16. X-ray absorption resonances near L2,3-edges from real-time propagation of the Dirac-Kohn-Sham density matrix.

    PubMed

    Kadek, Marius; Konecny, Lukas; Gao, Bin; Repisky, Michal; Ruud, Kenneth

    2015-09-21

    The solution of the Liouville-von Neumann equation in the relativistic Dirac-Kohn-Sham density matrix formalism is presented and used to calculate X-ray absorption cross sections. Both dynamical relaxation effects and spin-orbit corrections are included, as demonstrated by calculations of the X-ray absorption of SF6 near the sulfur L2,3-edges. We also propose an analysis facilitating the interpretation of spectral transitions from real-time simulations, and a selective perturbation that eliminates nonphysical excitations that are artifacts of the finite basis representation.

  17. A Week in the Life of Full-Time Office Workers: Work Day and Weekend Light Exposure in Summer and Winter

    PubMed Central

    Crowley, Stephanie J.; Molina, Thomas A.; Burgess, Helen J.

    2014-01-01

    Little is known about the light exposure in full-time office workers, who spend much of their workdays indoors. We examined the 24-hour light exposure patterns of 14 full-time office workers during a week in summer, and assessed their dim light melatonin onset (DLMO, a marker of circadian timing) at the end of the working week. Six workers repeated the study in winter. Season had little impact on the workers' schedules, as the timing of sleep, commute, and work did not vary by more than 30 minutes in the summer and winter. In both seasons, workers received significantly more morning light on workdays than weekends, due to earlier wake times and the morning commute. Evening light in the two hours before bedtime was consistently dim. The timing of the DLMO did not vary between season, and by the end of the working week, the workers slept at a normal circadian phase. PMID:25172304

  18. The timing of compositionally-zoned magma reservoirs and mafic 'priming' weeks before the 1912 Novarupta-Katmai rhyolite eruption

    NASA Astrophysics Data System (ADS)

    Singer, Brad S.; Costa, Fidel; Herrin, Jason S.; Hildreth, Wes; Fierstein, Judy

    2016-10-01

    The June, 6, 1912 eruption of more than 13 km3 of dense rock equivalent (DRE) magma at Novarupta vent, Alaska was the largest of the 20th century. It ejected >7 km3 of rhyolite, ∼1.3 km3 of andesite and ∼4.6 km3 of dacite. Early ideas about the origin of pyroclastic flows and magmatic differentiation (e.g., compositional zonation of reservoirs) were shaped by this eruption. Despite being well studied, the timing of events that led to the chemically and mineralogically zoned magma reservoir remain poorly known. Here we provide new insights using the textures and chemical compositions of plagioclase and orthopyroxene crystals and by reevaluating previous U-Th isotope data. Compositional zoning of the magma reservoir likely developed a few thousand years before the eruption by several additions of mafic magma below an extant silicic reservoir. Melt compositions calculated from Sr contents in plagioclase fill the compositional gap between 68 and 76% SiO2 in whole pumice clasts, consistent with uninterrupted crystal growth from a continuum of liquids. Thus, our findings support a general model in which large volumes of crystal-poor rhyolite are related to intermediate magmas through gradual separation of melt from crystal-rich mush. The rhyolite is incubated by, but not mixed with, episodic recharge pulses of mafic magma that interact thermochemically with the mush and intermediate magmas. Hot, Mg-, Ca-, and Al-rich mafic magma intruded into, and mixed with, deeper parts of the reservoir (andesite and dacite) multiple times. Modeling the relaxation of the Fe-Mg concentrations in orthopyroxene and Mg in plagioclase rims indicates that the final recharge event occurred just weeks prior to the eruption. Rapid addition of mass, volatiles, and heat from the recharge magma, perhaps aided by partial melting of cumulate mush below the andesite and dacite, pressurized the reservoir and likely propelled a ∼10 km lateral dike that allowed the overlying rhyolite to reach the

  19. A Poll about Children and Weight: Crunch Time during the American Work and School Week--3 P.M. to Bed

    ERIC Educational Resources Information Center

    Robert Wood Johnson Foundation, 2013

    2013-01-01

    Childhood obesity is a major public health challenge today, with complex roots interwoven into nearly every facet of American life. This poll addresses one narrow slice of this web: the challenges that families face during the "crunch time" of the work and school week, between 3 pm and the time children go to bed. Compared to the school day, this…

  20. A Poll about Children and Weight: Crunch Time during the American Work and School Week--3 P.M. to Bed. Summary

    ERIC Educational Resources Information Center

    Robert Wood Johnson Foundation, 2013

    2013-01-01

    Childhood obesity is a major public health challenge today, with complex roots interwoven into nearly every facet of American life. This poll addresses one narrow slice of this web: the challenges that families face during the "crunch time" of the work and school week, between 3 p.m. and the time children go to bed. Compared to the school day,…

  1. Development and validation of quantitative real-time polymerase chain reaction assays to detect elephant endotheliotropic herpesviruses-2, 3, 4, 5, and 6.

    PubMed

    Stanton, Jeffrey J; Nofs, Sally A; Peng, Rongsheng; Hayward, Gary S; Ling, Paul D

    2012-12-01

    Elephant endotheliotropic herpesviruses (EEHVs) can cause lethal hemorrhagic disease in both African and Asian elephants. At least seven EEHV types have been described, and sensitive real-time PCR tests have been developed for EEHV1A and 1B, which are associated with the majority of characterized Asian elephant deaths. Despite growing knowledge of the different EEHV types, the prevalence of each type within African and Asian elephants remains to be determined and there is considerable need for diagnostic tests to detect and discriminate between each EEHV species for clinical management of African and Asian elephants that develop illness from one or more of these viruses. To begin to address these issues, we developed real-time PCR assays for EEHV2, 3, 4, 5, and 6. Overall, each assay had robust PCR efficiency, a dynamic linear range over 5log(10) concentrations, a limit of detection of 10 copies/test reaction with 100% sensitivity, and low intra- and inter-assay variability. Each assay proved to be specific for the EEHV targets for which it was designed, with the exception of EEHV3 and EEHV4, which was expected because of greater DNA sequence similarity between these two EEHV species than the others. These new tools will be useful for conducting surveys of EEHV prevalence within captive and range country elephants, for diagnostic testing of elephants with suspected EEHV-associated disease, and for managing the treatment of elephants with EEHV-induced illness.

  2. Effect of freezing plasma at -20°C for 2 weeks on prothrombin time, activated partial thromboplastin time, dilute Russell viper venom time, activated protein C resistance, and D-dimer levels.

    PubMed

    Foshat, Michelle; Bates, Stephanie; Russo, Wendy; Huerta, Araceli; Albright, Kathleen; Giddings, Karen; Indrikovs, Alexander; Qian, You-Wen

    2015-01-01

    To assess the impact of preanalytical variables of time and temperature on prothrombin time (PT), activated partial thromboplastin time (aPTT), dilute Russell viper venom time (DRVVT), activated protein C resistance (APCR), and d-dimer, samples from 23 healthy individuals and 18 patients having coagulopathy with known abnormal PT and aPTT were collected. Plasma from each individual was separately pooled and aliquoted; the first 2 aliquots were stored at room temperature then analyzed at 2 hours (baseline) and 4 hours postcollection. The remaining aliquots were stored at -20°C and thawed for analysis at 48 hours, 1, and 2 weeks. In both healthy participants and participants with coagulopathy, PT, aPTT, APCR, DRVVT, and D-dimer had no significant changes at 4 and 48 hours, and 1 and 2 weeks postcollection compared to baseline, or the changes were less than 10%. The results indicate PT, aPTT, DRVVT, APCR, and d-dimer can be stored for 2 weeks at -20°C without compromising clinical interpretation in both healthy individuals and individuals with coagulopathy. Increasing storage time will facilitate sample processing from off-site clinics.

  3. Incubation time of Mycobacterium tuberculosis complex sputum cultures in BACTEC MGIT 960: Four weeks of negative culture is enough for physicians to consider alternative diagnoses

    PubMed Central

    Ogwang, Sam; Mubiri, Paul; Bark, Charles M.; Joloba, Moses L.; Boom, W. Henry; Johnson, John L.

    2015-01-01

    We retrospectively analyzed time to detection of 3747 positive MGIT sputum cultures at a laboratory in a country with heavy burden of tuberculosis. Ninety-nine percent of diagnostic cultures turned positive within 28 days, suggesting that physicians may consider alternative diagnoses if sputum cultures remain negative after 4 weeks of incubation. PMID:26239846

  4. Are the Effects of Early Pubertal Timing on the Initiation of Weekly Alcohol Use Mediated by Peers and/or Parents? A Longitudinal Study

    ERIC Educational Resources Information Center

    Schelleman-Offermans, Karen; Knibbe, Ronald A.; Kuntsche, Emmanuel

    2013-01-01

    We investigated whether the link between early pubertal timing and initiation of weekly alcohol use is mediated by changes in perceived parental alcohol-specific rule setting and changes in perceived proportion of drinkers in the peer group. Longitudinal data including 3 annual waves were used to estimate the hazard for adolescents to initiate…

  5. Weekly working hours for Norwegian hospital doctors since 1994 with special attention to postgraduate training, work–home balance and the European Working Time Directive: a panel study

    PubMed Central

    Rosta, Judith; Aasland, Olaf G

    2014-01-01

    Objectives To examine the weekly working hours of Norwegian hospital doctors from 1994 to 2012 with special emphasis on the quality of postgraduate training and work–home balance, and in relation to the requirements of the European Working Time Directive (EWTD). Design Panel study based on postal questionnaires. Setting Norway. Participants Unbalanced cohort of 1300–1600 doctors in 1994, 1995, 1996, 1997, 2000, 2002, 2004, 2006, 2008, 2010 and 2012. Outcome measures Self-reported total weekly working hours and whether 45 weekly working hours are too short, sufficient, or too long to meet the quality requirements of obligatory postgraduate training for junior doctors. Results From 1994 to 2012, the number of weekly working hours was stable for senior (46–47 h) and junior (45–46 h) hospital doctors. In 2012, significantly more senior (27–35%) than junior (11–20%) doctors reported suboptimal work–home balance, defined as working more than 48 h a week. The majority perceived the present situation with an average of 45 h per week for juniors as sufficient for obligatory postgraduate specialist training, but doctors of higher age (OR 1.04, 95% CI 1.01 to 1.08), senior doctors (1.07, 1.04 to 1.11) and doctors working in surgical specialties (OR 1 vs laboratory medicine 0.03, 0.01 to 0.25, internal medicine 0.31, 0.17 to 0.58, psychiatry 0.12, 0.04 to 0.36, paediatrics 0.36, 0.12 to 1.07, anaesthesiology 0.08, 0.02 to 0.39, gynaecology 0.07, 0.01 to 0.56 and others 0.39, 0.04 to 3.56) were more likely to want the work-week to be longer. Conclusions The weekly working hours of Norwegian hospital doctors were always below the EWTD requirements. A significant growth of hospital doctor density over the past two decades, national regulations and cultural values might be important factors. Specialty differences in perception of sufficient training time may call for more flexibility in working time regulations. PMID:25311038

  6. Design of peptide substrates for nanosecond time-resolved fluorescence assays of proteases: 2,3-diazabicyclo[2.2.2]oct-2-ene as a noninvasive fluorophore.

    PubMed

    Hennig, Andreas; Florea, Mara; Roth, Doris; Enderle, Thilo; Nau, Werner M

    2007-01-15

    Fluorescence protease assays were investigated with peptide substrates containing a 2,3-diazabicyclo[2.2.2]oct-2-ene-labeled asparagine (Dbo) as a fluorescent amino acid. The special characteristic of the fluorophore Dbo is its exceedingly long fluorescence lifetime (ca. 300 ns in water under air), which allows the use of nanosecond time-resolved fluorescence (Nano-TRF) detection to efficiently suppress shorter-lived background emission. In addition, the natural amino acids tryptophan and tyrosine can be employed as intramolecular fluorescence quenchers, which facilitates substrate design. Fourteen synthetic peptide substrates (composed of 2-19 amino acids) and five enzymes (trypsin, pepsin, carboxypeptidase A, leucine aminopeptidase, and chymotrypsin) were investigated and, in all 28 examined combinations, enzymatic activity was detected by monitoring the increase in steady state fluorescence with time and determining the reaction rates as kcat/Km values, which ranged from 0.2 to 80x10(6) M-1 min-1. The results suggest an excellent compatibility of the very small and hydrophilic fluorescent probe Dbo with solid-phase peptide synthesis and the investigated proteases. For all 14 peptides the fluorescence lifetimes before and after enzymatic cleavage were measured and Nano-TRF measurements were performed in 384-well microplates. The fluorescence lifetimes of the different peptides provide the basis for the rational design of Dbo-based fluorescent substrates for protease assays. Measurements in Nano-TRF mode revealed, in addition to efficient suppression of background fluorescence, an increased differentiation between cleaved and uncleaved substrate. The Dbo-based assays can be adapted for high-throughput screening.

  7. Relief of Night-time Symptoms Associated With Gastroesophageal Reflux Disease Following 4 Weeks of Treatment With Pantoprazole Magnesium: The Mexican Gastroesophageal Reflux Disease Working Group

    PubMed Central

    Orr, William; Vargas-Romero, José Antonio; Remes-Troche, José María; Morales-Arámbula, Miguel; Soto-Pérez, Julio César; Mateos-Pérez, Gualberto; Sobrino-Cossío, Sergio; Teramoto-Matsubara, Oscar; López-Colombo, Aurelio; Orozco-Gamiz, Antonio; Saez-Ríos, Adolfo; Arellano-Plancarte, Araceli; Chiu-Ugalde, Jazmin; Tholen, Anne; Horbach, Silke; Lundberg, Lars; Fass, Ronnie

    2014-01-01

    Background/Aims To evaluate the effectiveness of pantoprazole magnesium (pantoprazole-Mg) 40 mg in the relief of esophageal and extra-esophageal symptoms of gastroesophageal reflux disease (GERD), particularly night-time symptoms. Methods Patients (aged 18-50 years) with 3-month history of heartburn and/or acid regurgitation plus at least one other symptom in the last week were enrolled in a nationwide, prospective and observational study in Mexico. Patients received pantoprazole-Mg 40 mg once daily during 4 weeks. Symptoms were assessed through a physician-administered structured interview and the patient-completed ReQuest in Practice™ questionnaire. Night-time GERD was defined as arousal from sleep during the night due to GERD-associated symptoms. Results Out of 4,343 patients included at basal visit, 3,665 were considered for the effectiveness per protocol analysis. At baseline, patients had a median of 8 GERD related symptoms. Patients with night-time GERD symptoms (42.7%) were more likely to have extra-esophageal symptoms (P < 0.001) than other GERD patients. Pantoprazole-Mg 40 mg once daily for 4 weeks improved a broad range of GERD-associated symptoms from baseline (80% reduction on physicians assessments; 68-77% reduction on ReQuest in Practice™ dimensions), including both day- and night-time GERD symptoms; improvements were the greatest for extra-esophageal symptoms in patients with night-time symptoms. Pantoprazole-Mg was well tolerated. Conclusions Pantoprazole-Mg 40 mg significantly improved a broad range of esophageal and extra-esophageal GERD related symptoms including sleep disturbances, as well as well-being, in patients with daytime or night-time GERD, making it a good option for patients with GERD, especially when extra-esophageal and night-time symptoms are present. PMID:24466446

  8. The spectral variability of a sample of WC 9 stars on time-scales of days to weeks

    NASA Astrophysics Data System (ADS)

    Desforges, S.; St-Louis, N.; Chené, A.-N.; de la Chevrotière, A.; Hénault-Brunet, V.

    2017-02-01

    We present the results of a spectroscopic monitoring campaign of nine presumably single Wolf-Rayet (WR) stars, eight of type WC 9 and one WC 8d. We characterize their variability and search for clues to the mechanism responsible for the formation of dust in their wind. For seven out of eight WC 9s, we find a large-scale line-flux variability level of σ > 5-8 per cent. The only WC 8d star is variable at a level more comparable with those associated with wind clumping, σ = 2.2 per cent. The changes take place on a time-scale of days but in many cases, observing over longer time spans resulted in higher line-flux variability levels. The width of the substructures ranges from ∼150 to 300 km s-1, with the widest structures corresponding to stars with the highest variability amplitude. We searched for periodicities in integrated line quantities for C III λ5696. Radial velocity changes are typically ∼20 km s-1 but never exceed 40 km s-1 and are anticorrelated with the skewness of the line, strongly suggesting that they do not correspond to a real movement of the star. No periodicity was found in these integrated quantities, except for WR 103. Therefore, a wind-wind collision in a close binary does not seem to be responsible for the short-term variability. We cannot, however, exclude that these stars are intermediate- to long-period binaries. We estimate that for periods up to a few years, the shock-cone resulting from wind collisions would be non-adiabatic and thus unstable. We suggest that this represents a viable mechanism to explain the spectroscopic variability.

  9. Six weeks of aerobic training improves VO2max and MLSS but does not improve the time to fatigue at the MLSS.

    PubMed

    Mendes, Thiago Teixeira; Fonseca, Tatiana Ramos; Ramos, Guilherme Passos; Wilke, Carolina Franco; Cabido, Christian Emmanuel Torres; De Barros, Cristiano Lino Monteiro; Lima, André Maia; Mortimer, Lucas de Avila Carvalho Fleury; de Carvalho, Moisés Vieira; Teixeira, Mauro Martins; Lima, Nilo Resende Viana; Garcia, Emerson Silami

    2013-04-01

    The purpose of this study was to investigate the effects of a 6-week aerobic training period on the time to fatigue (t lim) during exercise performed at the maximal lactate steady state (MLSS). Thirteen untrained male subjects (TG; age 22.5 ± 2.4 years, body mass 72.9 ± 6.7 kg and VO2max 44.9 ± 4.8 mL kg(-1) min(-1)) performed a cycle ergometer test until fatigue at the MLSS power output before and after 6 weeks of aerobic training. A group of eight control subjects (CG; age 25.1 ± 2.4 years, body mass 70.1 ± 9.8 kg and VO2max 45.2 ± 4.1 mL kg(-1) min(-1)) also performed the two tests but did not train during the 6-week period. There were no differences between the groups with respect to the VO2max or MLSS power output (MLSSw) before the treatment period. The VO2max and the MLSSw of the TG increased by 11.2 ± 7.2 % (pre-treatment = 44.9 ± 4.8 vs. post-treatment = 49.8 ± 4.5 mL kg(-1) min(-1)) and 14.7 ± 8.9 % (pre-treatment = 150 ± 27 vs. post-treatment = 171 ± 26 W), respectively, after 6 weeks of training. The results of the CG were unchanged. There were no differences in t lim between the groups or within groups before and after training. Six weeks of aerobic training increases MLSSw and VO2max, but it does not alter the t lim at the MLSS.

  10. Three-times-weekly administration of teriparatide improves vertebral and peripheral bone density, microarchitecture, and mechanical properties without accelerating bone resorption in ovariectomized rats.

    PubMed

    Takao-Kawabata, Ryoko; Isogai, Yukihiro; Takakura, Aya; Shimazu, Yukari; Sugimoto, Emika; Nakazono, Osamu; Ikegaki, Ichiro; Kuriyama, Hiroshi; Tanaka, Shinya; Oda, Hiromi; Ishizuya, Toshinori

    2015-08-01

    Daily and weekly administration of teriparatide (PTH1-34) reduces the risk of osteoporotic bone fractures. However, their effects on markers of bone formation and bone resorption differ. These results indicate that the dosing frequency of teriparatide may affect bone metabolism and bone structure, with different effects on bone strength. In the present study, to evaluate the dose-related effects of a low administration frequency of teriparatide on bone status, we investigated the effects of three-times-weekly administration of teriparatide (1.1, 5.6, or 28.2 µg/kg) for 12 months on bone parameters, including bone metabolism markers, bone mineral density (BMD), micro-computed tomography, and bone strength, using 6-month-old ovariectomized (OVX) rats. Three-times-weekly administration of teriparatide dose-dependently increased the BMD of the lumbar vertebra and femur in OVX rats, and increased serum osteocalcin (a marker of bone formation), but not type I collagen C-telopeptide (a marker of bone resorption). The trabecular number and thickness increased in the vertebrae and femur, as in prior reports of daily teriparatide administration in OVX rats. Cortical thickness increased only toward the endocortical side of the femur, unlike with daily administration. Bone strength of the vertebrae and proximal and shaft of the femur was correlated with the changes in BMD and bone structure. These results demonstrate the effects of low frequency, intermittent administration of teriparatide on the biomechanical, and microstructural properties of bone in OVX rats.

  11. Prospects for Improved Forecasts of Weather and Short-Term Climate Variability on Subseasonal (2-Week to 2-Month) Times Scales

    NASA Technical Reports Server (NTRS)

    Schubert, Siegfried; Dole, Randall; vandenDool, Huug; Suarez, Max; Waliser, Duane

    2002-01-01

    This workshop, held in April 2002, brought together various Earth Sciences experts to focus on the subseasonal prediction problem. While substantial advances have occurred over the last few decades in both weather and seasonal prediction, progress in improving predictions on these intermediate time scales (time scales ranging from about two weeks to two months) has been slow. The goals of the workshop were to get an assessment of the "state of the art" in predictive skill on these time scales, to determine the potential sources of "untapped" predictive skill, and to make recommendations for a course of action that will accelerate progress in this area. One of the key conclusions of the workshop was that there is compelling evidence for predictability at forecast lead times substantially longer than two weeks. Tropical diabatic heating and soil wetness were singled out as particularly important processes affecting predictability on these time scales. Predictability was also linked to various low-frequency atmospheric "phenomena" such as the annular modes in high latitudes (including their connections to the stratosphere), the Pacific/North American (PNA) pattern, and the Madden Julian Oscillation (MJO). The latter, in particular, was highlighted as a key source of untapped predictability in the tropics and subtropics, including the Asian and Australian monsoon regions.

  12. Day of the week lost time occupational injury trends in the US by gender and industry and their implications for work scheduling.

    PubMed

    Brogmus, G E

    2007-03-01

    While there is a growing body of research on the impact of work schedules on the risk of occupational injuries, there has been little investigation into the impact that the day of the week might have. The present research was completed to explore day of the week trends, reasons for such trends and the corresponding implications for work scheduling. Data for the number of injuries and illnesses involving days away from work (lost time; LT) in 2004 were provided by the US Bureau of Labor Statistics Office of Safety and Health Statistics. Data from the American Time Use Survey database were used to estimate work hours in 2004. From these two data sources, the rate of LT injuries and illnesses (per 200 000 work hours) by day of the week, industry sector and gender were estimated. The analysis revealed clear differences by day of the week, gender and major industry sector. Sundays had the highest rate overall--nearly 37% higher than the average of the remaining days, Monday to Saturday. Mondays had the next highest rate followed closely by Saturdays. This pattern was not the same for males and females. For males, Mondays had the highest LT rate (27% higher than the average of all other days) with all remaining days having essentially the same rate. For females, Sundays and Saturdays had much higher LT rates--122% and 60% higher, respectively, than the average weekday rate. There were also differences by industry and differences between genders by industry. The present analysis suggests that several factors may be contributing to the weekend and Monday trends observed. Lower-tenured (and younger) workers on the weekends, lower female management/supervision and second jobs on the weekend seem to be contributors to the high Saturday and Sunday LT rates. Differences in day of the week employment by industry did not account for the trends observed. Fraud and overtime also could not be confirmed as contributing to these trends. Monday trends were more complex to explain, with

  13. SU-E-J-229: Quantitative Assessment for Timely Adaptive Re-Planning Using Weekly Dose Monitoring for Head and Neck Cancer

    SciTech Connect

    Shang, Q; Liu, H; Greskovich, J; Koyfman, S; Xia, P; Li, Z

    2014-06-01

    Purpose: For patients with head and neck (HN) cancer, mid-course adaptive radiation therapy (ART) is a common practice in our institution to accommodate anatomic changes. The aim of the study is to evaluate whether dose re-calculation on weekly verification images can provide quantitative assessment for timely adaptive re-planning with daily image-guided intensity modulated radiotherapy (IMRT). Methods: We retrospectively selected sixty daily verification images acquired on CT-on-rail/CBCT from ten HN patients. These image sets were typically a week apart. Among these patients, six patients received a mid-course ART. Contours of the tumors and organ-at-risks (OARs) were manually delineated by a physician on each verification CT. After placing the treatment iso-center on the verification CTs according to the recorded clinical shifts, daily dose was re-calculated with the same beam configuration as the original plan. For the purpose of this study, electron densities for both verification CTs and planning CTs were set to 1.0 g/cm3. Results: Two patients had D99 of the CTV < 97% of the planned dose for more than three fractions due to remarkable tumor volume shrinkages. D-max of the spinal cord exceeded a tolerance of 45 Gy for four fractions in additional two patients. D-mean of the parotid increased within 25% of the planned value. D-max of the brainstem and D-mean of the oral cavity did not show significant variation. If the re-planning criteria included D99 of the CTV < 97% of the planned dose and D-max of the spinal cord > 45 Gy, two out ten patients required ART at week 2 and two patients required ART at week 3, respectively. Conclusion: Weekly dose monitoring with re-calculation on verification images can provide quantitative dose guidance for timely adaptive re-planning. Future work will include accumulative dose analysis for the decision of adaptive re-planning. The study is supported in part by Siemens Medical Solutions.

  14. Objective assessment of sedentary time and physical activity throughout the week in adolescents with Down syndrome. The UP&DOWN study.

    PubMed

    Izquierdo-Gomez, Rocío; Martínez-Gómez, David; Acha, Aitor; Veiga, Oscar L; Villagra, Ariel; Diaz-Cueto, Mario

    2014-02-01

    This study aimed to examine the patterns of sedentary time and physical activity (PA) throughout the week in adolescents with Down syndrome (DS). The study comprised 109 adolescents with DS (68 males and 41 females) aged 11-20 years, participating in the UP&DOWN study, but only a total of 100 adolescents provided valid data. Sedentary time and total, light, moderate, vigorous, and moderate-to-vigorous PA (MVPA) were measured by accelerometers. There were no significant differences in the time spent in sedentary time and PA levels between weekdays vs. weekend days, as well as between school time vs. after school-time periods (all p>0.05). Adolescent males engaged in more total PA, moderate PA, vigorous PA and MVPA than females on weekend days (all p<0.05). Differences between age groups showed that sedentary time increases and PA decreases with advancing age in all analyses, so that the oldest groups were more sedentary and less active (all p<0.05). Only 43% of adolescents with DS met the PA recommendations of ≥60min/day of MVPA. Our findings show valuable information to be considered in future interventions aiming to decrease sedentary time and increase PA levels in adolescents with DS.

  15. Earth Science Week evolves

    NASA Astrophysics Data System (ADS)

    Earth Science Week, October 7-13, is an annual grassroots effort sponsored by the American Geological Institute (AGI) and its member societies, of which AGU is the largest. This year, for the first time, Earth Science Week has a general theme, evolution in Earth history. The Earth Science Week information kit for 2001, available from AGI, includes a variety of posters, bookmarks, and other materials that illustrate this concept. The kit contains a new 32-page “Ideas and Activities” booklet that emphasizes evolution in Earth history through an array of activities about rocks, fossils, and geologic time. It also has information on the upcoming Public Broadcasting Service series, “Evolution,” which is to be aired in late September.

  16. 2,3-Dichloropropanol

    Integrated Risk Information System (IRIS)

    2,3 - Dichloropropanol ; CASRN 616 - 23 - 9 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarcino

  17. The generalized STAR(1,1) modeling with time correlated errors to red-chili weekly prices of some traditional markets in Bandung, West Java

    NASA Astrophysics Data System (ADS)

    Nisa Fadlilah F., I.; Mukhaiyar, Utriweni; Fahmi, Fauzia

    2015-12-01

    The observations at a certain location may be linearly influenced by the previous times of observations at that location and neighbor locations, which could be analyzed by Generalized STAR(1,1). In this paper, the weekly red-chili prices secondary-data of five main traditional markets in Bandung are used as case study. The purpose of GSTAR(1,1) model is to forecast the next time red-chili prices at those markets. The model is identified by sample space-time ACF and space-time PACF, and model parameters are estimated by least square estimation method. Theoretically, the errors' independency assumption could simplify the parameter estimation's problem. However, practically that assumption is hard to satisfy since the errors may be correlated each other's. In red-chili prices modeling, it is considered that the process has time-correlated errors, i.e. martingale difference process, instead of follow normal distribution. Here, we do some simulations to investigate the behavior of errors' assumptions. Although some of results show that the behavior of the errors' model are not always followed the martingale difference process, it does not corrupt the goodness of GSTAR(1,1) model to forecast the red-chili prices at those five markets.

  18. Twelve Weeks of Sprint Interval Training Improves Indices of Cardiometabolic Health Similar to Traditional Endurance Training despite a Five-Fold Lower Exercise Volume and Time Commitment

    PubMed Central

    Martin, Brian J.; MacInnis, Martin J.; Skelly, Lauren E.; Tarnopolsky, Mark A.; Gibala, Martin J.

    2016-01-01

    Aims We investigated whether sprint interval training (SIT) was a time-efficient exercise strategy to improve insulin sensitivity and other indices of cardiometabolic health to the same extent as traditional moderate-intensity continuous training (MICT). SIT involved 1 minute of intense exercise within a 10-minute time commitment, whereas MICT involved 50 minutes of continuous exercise per session. Methods Sedentary men (27±8y; BMI = 26±6kg/m2) performed three weekly sessions of SIT (n = 9) or MICT (n = 10) for 12 weeks or served as non-training controls (n = 6). SIT involved 3x20-second ‘all-out’ cycle sprints (~500W) interspersed with 2 minutes of cycling at 50W, whereas MICT involved 45 minutes of continuous cycling at ~70% maximal heart rate (~110W). Both protocols involved a 2-minute warm-up and 3-minute cool-down at 50W. Results Peak oxygen uptake increased after training by 19% in both groups (SIT: 32±7 to 38±8; MICT: 34±6 to 40±8ml/kg/min; p<0.001 for both). Insulin sensitivity index (CSI), determined by intravenous glucose tolerance tests performed before and 72 hours after training, increased similarly after SIT (4.9±2.5 to 7.5±4.7, p = 0.002) and MICT (5.0±3.3 to 6.7±5.0 x 10−4 min-1 [μU/mL]-1, p = 0.013) (p<0.05). Skeletal muscle mitochondrial content also increased similarly after SIT and MICT, as primarily reflected by the maximal activity of citrate synthase (CS; P<0.001). The corresponding changes in the control group were small for VO2peak (p = 0.99), CSI (p = 0.63) and CS (p = 0.97). Conclusions Twelve weeks of brief intense interval exercise improved indices of cardiometabolic health to the same extent as traditional endurance training in sedentary men, despite a five-fold lower exercise volume and time commitment. PMID:27115137

  19. Variation in the human lymphocyte sister chromatid exchange frequency as a function of time: results of daily and twice-weekly sampling

    SciTech Connect

    Tucker, J.D.; Christensen, M.L.; Strout, C.L.; McGee, K.A.; Carrano, A.V.

    1987-01-01

    The variation in lymphocyte sister chromatid exchange (SCE) frequency was investigated in healthy nonsmokers who were not taking any medication. Two separate studies were undertaken. In the first, blood was drawn from four women twice a week for 8 weeks. These donors recorded the onset and termination of menstruation and times of illness. In the second study, blood was obtained from two women and two men for 5 consecutive days on two separate occasions initiated 14 days apart. Analysis of the mean SCE frequencies in each study indicated that significant temporal variation occurred in each donor, and that more variation occurred in the longer study. Some of the variation was found to be associated with the menstrual cycle. In the daily study, most of the variation appeared to be random, but occasional day-to-day changes occurred that were greater than those expected by chance. To determine how well a single SCE sample estimated the pooled mean for each donor in each study, the authors calculated the number of samples that encompassed that donor's pooled mean within 1 or more standard errors. For both studies, about 75% of the samples encompassed the pooled mean within 2 standard errors. An analysis of high-frequency cells (HFCs) was also undertaken. The results for each study indicate that the proportion of HFCs, compared with the use of Fisher's Exact test, is significantly more constant than the means, which were compared by using the t-test. These results coupled with our previous work suggest that HFC analysis may be the method of choice when analyzing data from human population studies.

  20. Decreasing the frequency of energy supplementation from daily to three times weekly impairs growth and humoral immune response of preconditioning beef steers.

    PubMed

    Artioli, L F A; Moriel, P; Poore, M H; Marques, R S; Cooke, R F

    2015-11-01

    We evaluated the effects of frequency of energy supplementation on growth and measurements of innate and humoral immune responses of preconditioning beef steers following vaccination. Angus steers ( = 24; 221 ± 6.3 kg; 177 ± 4 d of age) were weaned on d -7 and kept in a single drylot pen with free access to tall fescue hay and concentrate DMI at 0.5% of BW (50:50 mix of soyhulls and corn gluten pellets; DM basis) from d -7 to 0. On d 0, steers were stratified by BW and age and randomly assigned to 1 of 8 feedlot pens (3 steers/pen). Treatments were randomly assigned to pens (4 pens/treatment) and consisted of steers provided daily free access to ground tall fescue hay and similar weekly concentrate DMI (1% of BW times 7 d), which was divided and offered either daily (S7) or 3 times weekly (S3; Monday, Wednesday, and Friday) from d 0 to 42. Individual BW was measured before feeding on d 0 and 42, after 12 h of feed and water withdrawal. Steers were vaccinated against infectious bovine rhinotracheitis, bovine viral diarrhea virus (BVDV), and clostridium on d 7 and 21. Blood samples were collected from the jugular vein on d -7 and 4 h after concentrate supplementation on d 0, 7, 8, 9, 10, 14, 21, 22, 23, 24, 28, 35, and 42. Steers offered concentrate daily had greater ( ≤ 0.02) BW on d 42, overall ADG, and total DMI, but similar ( = 0.14) G:F, than S3 steers. On days that S7 and S3 steers were offered concentrate, total DMI was greater and hay DMI was less for S3 vs. S7 steers ( ≤ 0.05). On days that only S7 steers were supplemented, hay DMI was greater, but total DMI was less for S3 vs. S7 steers ( ≤ 0.05). Mean CP and NEg intake were greater ( ≤ 0.03) for S7 vs. S3 steers. Plasma cortisol concentrations on d 7 and 28, and mean plasma haptoglobin concentrations, but not liver mRNA expression of haptoglobin ( = 0.75), were greater for S3 vs. S7 steers ( ≤ 0.03). Plasma IGF-1 concentrations on d 0 and urea nitrogen on d 1 and 3, relative to vaccination

  1. Effects of Six versus Three Times per Week Hemodialysis on Physical Performance, Health, and Functioning: Frequent Hemodialysis Network (FHN) Randomized Trials

    PubMed Central

    Larive, Brett; Painter, Patricia; Kaysen, George A.; Lindsay, Robert M.; Nissenson, Allen R.; Unruh, Mark L.; Rocco, Michael V.; Chertow, Glenn M.

    2012-01-01

    Summary Background and objectives Relatively little is known about the effects of hemodialysis frequency on the disability of patients with ESRD. Design, setting, participants, & measurements This study examined changes in physical performance and self-reported physical health and functioning among subjects randomized to frequent (six times per week) compared with conventional (three times per week) hemodialysis in both the Frequent Hemodialysis Network daily (n=245) and nocturnal (n=87) trials. The main outcome measures were adjusted change in scores over 12 months on the short physical performance battery (SPPB), RAND 36-item health survey physical health composite (PHC), and physical functioning subscale (PF) based on the intention to treat principle. Results Overall scores for SPPB, PHC, and PF were poor relative to population norms and in line with other studies in ESRD. In the Daily Trial, subjects randomized to frequent compared with conventional in-center hemodialysis experienced no significant change in SPPB (adjusted mean change of −0.20±0.19 versus −0.41±0.21, P=0.45) but experienced significant improvement in PHC (3.4±0.8 versus 0.4±0.8, P=0.009) and a relatively large change in PF that did not reach statistical significance. In the Nocturnal Trial, there were no significant differences among subjects randomized to frequent compared with conventional hemodialysis in SPPB (adjusted mean change of −0.92±0.44 versus −0.41±0.43, P=0.41), PHC (2.7±1.4 versus 2.1±1.5, P=0.75), or PF (−3.1±3.5 versus 1.1±3.6, P=0.40). Conclusions Frequent in-center hemodialysis compared with conventional in-center hemodialysis improved self-reported physical health and functioning but had no significant effect on objective physical performance. There were no significant effects of frequent nocturnal hemodialysis on the same physical metrics. PMID:22422538

  2. Biogeochemical variations at the Porcupine Abyssal Plain Sustained Observatory (PAP-SO) in the northeast Atlantic Ocean, from weekly to inter-annual time scales

    NASA Astrophysics Data System (ADS)

    Hartman, S. E.; Jiang, Z.-P.; Turk, D.; Lampitt, R. S.; Frigstad, H.; Ostle, C.

    2014-08-01

    We present high-resolution autonomous measurements of carbon dioxide partial pressure p(CO2) taken in situ at the Porcupine Abyssal Plain sustained observatory (PAP-SO) in the Northeast Atlantic (49° N, 16.5° W; water depth of 4850 m) for the period 2010 to 2012. Measurements of p(CO2) made at 30 m depth on a sensor frame are compared with other autonomous biogeochemical measurements at that depth (including chlorophyll a-fluorescence and nitrate concentration data) to analyse weekly to seasonal controls on p(CO2) flux in the inter-gyre region of the North Atlantic. Comparisons are also made with in situ regional time-series data from a ship of opportunity and mixed layer depth (MLD) measurements from profiling Argo floats. There is a persistent under saturation of CO2 in surface waters throughout the year which gives rise to a perennial CO2 sink. Comparison with an earlier dataset collected at the site (2003 to 2005) confirms seasonal and inter-annual changes in surface seawater chemistry. There is year-to-year variability in the timing of stratification and deep winter mixing. The 2010 to 2012 period shows an overall increase in p(CO2) values when compared to the 2003-2005 period. This is despite similar surface temperature, wind speed and MLD measurements between the two periods of time. Future work should incorporate daily CO2 flux measurements made using CO2 sensors at 1 m depth and the in situ wind speed data now available from the UK Met Office Buoy.

  3. Biogeochemical variations at the Porcupine Abyssal Plain Sustained Observatory (PAP-SO) in the northeast Atlantic Ocean, from weekly to inter-annual time scales

    NASA Astrophysics Data System (ADS)

    Hartman, Susan; Lampitt, Richard

    2015-04-01

    We present high-resolution autonomous measurements of carbon dioxide partial pres- sure p(CO2) taken in situ at the Porcupine Abyssal Plain sustained observatory (PAP- SO) in the northeast Atlantic (49N, 16.5W; water depth of 4850 m) for the period 2010 to 2012. Measurements of p(CO2) made at 30 m depth on a sensor frame are compared with other autonomous biogeochemical measurements at that depth (including chlorophyll a-fluorescence and nitrate concentration data) to analyse weekly to seasonal controls on p(CO2) flux in the inter-gyre region of the North Atlantic. Comparisons are also made with in situ regional time-series data from a ship of opportunity and mixed layer depth (MLD) measurements from profiling Argo floats. There is a persistent under saturation of CO2 in surface waters throughout the year which gives rise to a perennial CO2 sink. Comparison with an earlier dataset collected at the site (2003 to 2005) confirms seasonal and inter-annual changes in surface seawater chemistry. There is year-to-year variability in the timing of deep winter mixing and the intensity of the spring bloom. The 2010-2012 period shows an overall increase in p(CO2) values when compared to the 2003-2005 period as would be expected from increases due to anthropogenic CO2 emissions. The surface temperature, wind speed and MLD measurements are similar for both periods of time. Future work should incorporate daily CO2 flux measurements made using CO2 sensors at 1 m depth and the in situ wind speed data now available from the UK Met Office Buoy.

  4. Early fetal gender determination using real-time PCR analysis of cell-free fetal DNA during 6th-10th weeks of gestation.

    PubMed

    Khorram Khorshid, Hamid Reza; Zargari, Maryam; Sadeghi, Mohammad Reza; Edallatkhah, Haleh; Shahhosseiny, Mohammad Hassan; Kamali, Koorosh

    2013-05-07

    Nowadays, new advances in the use of cell free fetal DNA (cffDNA) in maternal plasma of pregnant women has provided the possibility of applying cffDNA in prenatal diagnosis as a non-invasive method. In contrary to the risks of invasive methods that affect both mother and fetus, applying cffDNA is proven to be highly effective with lower risk. One of the applications of prenatal diagnosis is fetal gender determination, which is important in fetuses at risk of sex-linked genetic diseases. In such cases by obtaining the basic information of the gender, necessary time management can be taken in therapeutic to significantly reduce the necessity of applying the invasive methods. Therefore in this study, the probability of detecting sequences on the human Y-chromosome in pregnant women has been evaluated to identify the gender of fetuses. Peripheral blood samples were obtained from 80 pregnant women with gestational age between 6th to 10th weeks and the fetal DNA was extracted from the plasma. Identification of SRY, DYS14 & DAZ sequences, which are not presentin the maternal genome, was performed using Real-Time PCR. All the obtained results were compared with the actual gender of the newborns to calculate the test accuracy. Considerable 97.3% sensitivity and 97.3% specificity were obtained in fetal gender determination which is significant in the first trimester of pregnancy. Only in one case, false positive result was obtained. Using non-invasive method of cffDNAs in the shortest time possible, as well as avoiding invasive tests for early determination of fetal gender, provides the opportunity of deciding and employing early treatment for fetuses at risk of genetic diseases.

  5. Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors.

    PubMed

    Shemer, Isaac; Holmgren, Carl; Min, Rogier; Fülöp, Livia; Zilberter, Misha; Sousa, Kyle M; Farkas, Tamás; Härtig, Wolfgang; Penke, Botond; Burnashev, Nail; Tanila, Heikki; Zilberter, Yuri; Harkany, Tibor

    2006-04-01

    Cognitive decline in Alzheimer's disease (AD) stems from the progressive dysfunction of synaptic connections within cortical neuronal microcircuits. Recently, soluble amyloid beta protein oligomers (Abeta(ol)s) have been identified as critical triggers for early synaptic disorganization. However, it remains unknown whether a deficit of Hebbian-related synaptic plasticity occurs during the early phase of AD. Therefore, we studied whether age-dependent Abeta accumulation affects the induction of spike-timing-dependent synaptic potentiation at excitatory synapses on neocortical layer 2/3 (L2/3) pyramidal cells in the APPswe/PS1dE9 transgenic mouse model of AD. Synaptic potentiation at excitatory synapses onto L2/3 pyramidal cells was significantly reduced at the onset of Abeta pathology and was virtually absent in mice with advanced Abeta burden. A decreased alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/N-methyl-D-aspartate (NMDA) receptor-mediated current ratio implicated postsynaptic mechanisms underlying Abeta synaptotoxicity. The integral role of Abeta(ol)s in these processes was verified by showing that pretreatment of cortical slices with Abeta((25-35)ol)s disrupted spike-timing-dependent synaptic potentiation at unitary connections between L2/3 pyramidal cells, and reduced the amplitude of miniature excitatory postsynaptic currents therein. A robust decrement of AMPA, but not NMDA, receptor-mediated currents in nucleated patches from L2/3 pyramidal cells confirmed that Abeta(ol)s perturb basal glutamatergic synaptic transmission by affecting postsynaptic AMPA receptors. Inhibition of AMPA receptor desensitization by cyclothiazide significantly increased the amplitude of excitatory postsynaptic potentials evoked by afferent stimulation, and rescued synaptic plasticity even in mice with pronounced Abeta pathology. We propose that soluble Abeta(ol)s trigger the diminution of synaptic plasticity in neocortical pyramidal cell networks during early

  6. Six-week time series of eddy covariance CO2 flux at Mammoth Mountain, California: performance evaluation and role of meteorological forcing

    SciTech Connect

    Lewicki, Jennifer; Lewicki, J.L.; Fischer, M.L.; Hilley, G.E.

    2007-10-15

    CO{sub 2} and heat fluxes were measured over a six-week period (09/08/2006 to 10/24/2006) by the eddy covariance (EC) technique at the Horseshoe Lake tree kill (HLTK), Mammoth Mountain, CA, a site with complex terrain and high, spatially heterogeneous CO{sub 2} emission rates. EC CO{sub 2} fluxes ranged from 218 to 3500 g m{sup -2} d{sup -1} (mean = 1346 g m{sup -2} d{sup -1}). Using footprint modeling, EC CO{sub 2} fluxes were compared to CO{sub 2} fluxes measured by the chamber method on a grid repeatedly over a 10-day period. Half-hour EC CO{sub 2} fluxes were moderately correlated (R{sup 2} = 0.42) with chamber fluxes, whereas average-daily EC CO{sub 2} fluxes were well correlated (R{sup 2} = 0.70) with chamber measurements. Average daily EC CO{sub 2} fluxes were correlated with both average daily wind speed and atmospheric pressure; relationships were similar to those observed between chamber CO{sub 2} fluxes and the atmospheric parameters over a comparable time period. Energy balance closure was assessed by statistical regression of EC energy fluxes (sensible and latent heat) against available energy (net radiation, less soil heat flux). While incomplete (R{sup 2} = 0.77 for 1:1 line), the degree of energy balance closure fell within the range observed in many investigations conducted in contrasting ecosystems and climates. Results indicate that despite complexities presented by the HLTK, EC can be reliably used to monitor background variations in volcanic CO{sub 2} fluxes associated with meteorological forcing, and presumably changes related to deeply derived processes such as volcanic activity.

  7. Real-time Polymerase Chain Reaction Analysis of Sewage Samples to Determine Oral Polio Vaccine Circulation Duration and Mutation After Mexican National Immunization Weeks

    PubMed Central

    Troy, Stephanie B.; Ferreyra-Reyes, Leticia; Canizales-Quintero, Sergio; Huang, ChunHong; Lee, Yu-Jin; Báez-Saldaña, Renata; Ferreira-Guerrero, Elizabeth; García-García, Lourdes; Maldonado, Yvonne

    2012-01-01

    Background. Oral polio vaccine (OPV) can mutate and cause outbreaks of paralytic poliomyelitis with prolonged replication. After poliovirus eradication, global use of inactivated polio vaccine (IPV) may be needed until all OPV stops circulating. Mexico, where children receive routine IPV but where OPV is given only during biannual national immunization weeks (NIWs), provides a natural setting to study duration of OPV circulation in a community primarily vaccinated with IPV. Methods. One-liter sewage samples from four separate arroyos (creeks) near Orizaba, Mexico, were collected monthly for 12 months. Concentrated sewage underwent RNA extraction, reverse transcription, and real-time polymerase chain reaction (PCR) to detect OPV serotypes 1, 2, and 3 and their variants containing the serotype-specific point mutation in the 5′ untranslated region associated with neurovirulence. Results. OPV was detected 3, 4, 5, and 7 months after the May 2010 NIW, but was not detected at 6 or 8 months. A second and third NIW occurred in February 2011 and May 2011, and OPV was detected in the sewage monthly after both of these NIW through July 2011 when collection stopped. The OPV detected was primarily serotype 2 and predominantly contained the point mutations in the 5′ untranslated region associated with increased neurovirulence. Conclusions. OPV was detected in sewage as late as 7 months after an NIW in a Mexican community primarily vaccinated with IPV, but was not detected at 8 months, suggesting that OPV circulation may have ceased. These data suggest that in communities with high vaccination rates, 1 or 2 years of IPV administration after OPV cessation could be sufficient to prevent outbreaks of paralytic poliomyelitis from vaccine-derived strains. PMID:23667738

  8. Optimal Timing for Assessment of Tumor Response to Neoadjuvant Chemoradiation in Patients With Rectal Cancer: Do All Patients Benefit From Waiting Longer Than 6 Weeks?

    SciTech Connect

    Perez, Rodrigo O.; Habr-Gama, Angelita; Sao Juliao, Guilherme P.; Gama-Rodrigues, Joaquim; Sousa, Afonso H.S.; Campos, Fabio Guilherme; Imperiale, Antonio R.; Lynn, Patricio B.; Proscurshim, Igor; Nahas, Sergio Carlos; Ono, Carla Rachel; Buchpiguel, Carlos Alberto

    2012-12-01

    Purpose: To estimate the metabolic activity of rectal cancers at 6 and 12 weeks after completion of chemoradiation therapy (CRT) by 2-[fluorine-18] fluoro-2-deoxy-D-glucose-labeled positron emission tomography/computed tomography ([{sup 18}FDG]PET/CT) imaging and correlate with response to CRT. Methods and Materials: Patients with cT2-4N0-2M0 distal rectal adenocarcinoma treated with long-course neoadjuvant CRT (54 Gy, 5-fluouracil-based) were prospectively studied ( (ClinicalTrials.org) identifier (NCT00254683)). All patients underwent 3 PET/CT studies (at baseline and 6 and 12 weeks from CRT completion). Clinical assessment was at 12 weeks. Maximal standard uptake value (SUVmax) of the primary tumor was measured and recorded at each PET/CT study after 1 h (early) and 3 h (late) from {sup 18}FDG injection. Patients with an increase in early SUVmax between 6 and 12 weeks were considered 'bad' responders and the others as 'good' responders. Results: Ninety-one patients were included; 46 patients (51%) were 'bad' responders, whereas 45 (49%) patients were 'good' responders. 'Bad' responders were less likely to develop complete clinical response (6.5% vs. 37.8%, respectively; P=.001), less likely to develop significant histological tumor regression (complete or near-complete pathological response; 16% vs. 45%, respectively; P=.008) and exhibited greater final tumor dimension (4.3 cm vs. 3.3 cm; P=.03). Decrease between early (1 h) and late (3 h) SUVmax at 6-week PET/CT was a significant predictor of 'good' response (accuracy of 67%). Conclusions: Patients who developed an increase in SUVmax after 6 weeks were less likely to develop significant tumor downstaging. Early-late SUVmax variation at 6-week PET/CT may help identify these patients and allow tailored selection of CRT-surgery intervals for individual patients.

  9. a week in space

    NASA Astrophysics Data System (ADS)

    collette, christian

    2016-04-01

    COLLETTE Christian Institut Saint Laurent Liège Belgium. I am a science teacher at a technical high school. Generally, my students don't come from a privileged social background and are not particularly motivated for studies. For 10 years, I organize, for one of my sections, a spatial (and special) school year that ends in a spatial week. Throughout this year, with the help of my colleagues, I will introduce into all themes a lot of concepts relating to space. French, history, geography, English, mathematics, technical courses, sciences, and even gymnastics will be training actors in space culture. In spring, I will accompany my class in the Euro Space Center (Redu- Belgium) where we will live one week 24 hours on "like astronauts" One third of the time is dedicated to astronaut training (moonwalk, remote manipulator system, mission simulation, weightless wall, building rockets, satellites, etc.), One third to more intellectual activities on space (lectures, research, discovery of the outside run) the last one third of time in outside visits (museums, site of ESA-Redu) or in movies about space (October sky, Apollo 13, etc.) During this year, the profits, so educational as human, are considerable!

  10. The Effect of Three Times a Week Glatiramer Acetate on Cerebral T1 Hypointense Lesions in Relapsing‐Remitting Multiple Sclerosis

    PubMed Central

    Dwyer, Michael G.; Ramasamy, Deepa P.; Davis, Mat D.; Steinerman, Joshua R.; Khan, Omar

    2015-01-01

    ABSTRACT BACKGROUND AND PURPOSE Two definitions of T1 hypointense (T1H) lesions can be derived from pre‐contrast images: those that may or may not have a corresponding gadolinium‐enhancing correlate on post‐contrast images (T1H total), and those that are simultaneously non‐gadolinium‐enhancing on post‐contrast scans (T1H non‐enhancing). To determine the differences in lesion evolution between these two T1H definitions, we examined the effect of glatiramer acetate 40 mg/mL three times weekly subcutaneous injection (GA40) on the number of new or enlarging T1H total and T1H non‐enhancing lesions in patients with relapsing‐remitting multiple sclerosis (RRMS). METHODS The Phase III GALA study randomized 1404 RRMS subjects 2:1 to receive GA40 or placebo for 12 months. MRI scans were obtained at baseline and at months 6 and 12. Cumulative numbers of T1H total and of T1H non‐enhancing lesions were analyzed using an adjusted negative binomial regression model. A total of 1,357 patients had MRI data collected at either the month 6 or month 12 visit. RESULTS Among the 1,357 patients with MRI scans performed at either the month 6 or month 12 visit, 883 treated with GA40 developed an adjusted cumulative mean of 1.72 T1H total lesions versus 2.62 in 440 placebo controls (risk ratio, .66; 95% CI, .54‐.80; P < .0001). On T1H non‐enhanced scans, GA40‐treated patients developed an adjusted cumulative mean of 1.35 T1H non‐enhancing lesions versus 1.91 in placebo controls (risk ratio, .71; CI, .58‐.87; P = .0009). CONCLUSIONS GA40 significantly reduced the number of new or enlarging T1H total lesions and T1H non‐enhancing lesions compared with placebo. Although the treatment effect magnitude was comparable with both definitions, the use of T1H non‐enhancing lesions may be more relevant for more uniform standardization in future clinical trials. PMID:26394270

  11. Concentration-and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to twelve weeks

    EPA Science Inventory

    Inorganic arsenic (AsD is a known human bladder carcinogen. The objective of this study was to examine the concentration dependence of the genomic response to ASi in the urinary bladders of mice. C57BL/6J mice were exposed for 1 or 12 weeks to arsenate in drinking water at concen...

  12. Comparative Study of Ultraviolet Laser-Based Time-Resolved Photoacoustic Fingerprint Spectra and Thermal Decomposition Mechanisms of Energetic 1,2,3-1H-Triazole Derivatives Under Controlled Pyrolysis.

    PubMed

    Rao, Konda Srinivasa; Chaudhary, Anil Kumar

    2017-01-01

    We report the comparative study of photoacoustic (PA) fingerprint spectra, thermal decomposition, and stability mechanism of some phenyl and bis series energetic compounds named 1-(2-methoxy,-3,5-dinitrophenyl)-1H-1,2,3-triazole ( S5), 1-(3-methoxy, 2, 6 dinitrophenyl) 1H-1, 2, 3 triazole ( S10), 1-(4-nitrophenyl)-1H-1,2,3-triazole ( S8), and 2,6-bis ((4-(nitromethyl)-1H-1,2,3-triazol-1-yl)methyl) pyridine ( S9). Fourth harmonic wavelength, i.e., 266 nm of pulse duration 7 ns and 10 Hz repetition rate obtained from Q-switched Nd: YAG laser, was used to record the thermal PA spectra of these compounds under controlled pyrolysis condition in the range of 30-350 ℃. The PA fingerprint spectra are produced due to entire molecule vapor along with principal functional byproduct NO2 molecule. NO2 molecule is a major gas released during thermal decomposition due to weakest nature of C-NO2 bond. Further, NO2 molecules are involved in photodissociation process due to π*← n transition and converted into NO molecules inside the PA cell due to excitation by 266 nm wavelength. The combined results of PA and gas chromatography-mass spectrometry (GC-MS) spectra along with thermo gravimetric-differential thermal analysis (TG-DTA) data confirm the thermal decomposition mechanism process that can be completed in multiple steps. In addition, GC-MS spectra also confirm the release of NO and NO2 molecules. The effect of incident laser energy and data acquisition time has been carried out for understanding the behavior of acoustic modes. Finally, the thermal quality factor "Q" is measured to test the stability of compounds.

  13. Concentration- and time-dependent genomic changes in the mouse urinary bladder following exposure to arsenate in drinking water for up to 12 weeks.

    PubMed

    Clewell, H J; Thomas, R S; Kenyon, E M; Hughes, M F; Adair, B M; Gentry, P R; Yager, J W

    2011-10-01

    Inorganic arsenic (As(i)) is a known human bladder carcinogen. The objective of this study was to examine the concentration dependence of the genomic response to As(i) in the urinary bladders of mice. C57BL/6J mice were exposed for 1 or 12 weeks to arsenate in drinking water at concentrations of 0.5, 2, 10, and 50 mg As/l. Urinary bladders were analyzed using gene expression microarrays. A consistent reversal was observed in the direction of gene expression change: from predominantly decreased expression at 1 week to predominantly increased expression at 12 weeks. These results are consistent with evidence from in vitro studies of an acute adaptive response that is suppressed on longer exposure due to downregulation of Fos. Pathways with the highest enrichment in gene expression changes were associated with epithelial-to-mesenchymal transition, inflammation, and proliferation. Benchmark dose (BMD) analysis determined that the lowest median BMD values for pathways were above 5 mg As/l, despite the fact that pathway enrichment was observed at the 0.5 mg As/l exposure concentration. This disparity may result from the nonmonotonic nature of the concentration-responses for the expression changes of a number of genes, as evidenced by the much fewer gene expression changes at 2 mg As/l compared with lower or higher concentrations. Pathway categories with concentration-related gene expression changes included cellular morphogenesis, inflammation, apoptosis/survival, cell cycle control, and DNA damage response. The results of this study provide evidence of a concentration-dependent transition in the mode of action for the subchronic effects of As(i) in mouse bladder cells in the vicinity of 2 mg As(i)/l.

  14. Optimal timing for nasal fracture manipulation - is a two week target really necessary? A single-centre retrospective analysis of 50 patients.

    PubMed

    Perkins, V; Vijendren, A; Egan, M; McRae, D

    2017-04-04

    Nasal bone fractures represent the most common isolated facial fracture and are involved in as many as 50% of facial fractures ((1)) . Its relative prominence in the centre of the face as well as its relatively thin, fragile structures makes it particularly susceptible to injury. Acute management is centred on restoring an aesthetically acceptable external nose with minimal airflow limitation. Conventional UK management typically involves assessment 5-7 days following injury, followed by closed reduction within two weeks, to avoid problems associated with fracture healing and bone remodelling ((2)) . This article is protected by copyright. All rights reserved.

  15. 32-Week Holding-Time Study of SUMMA Polished Canisters and Triple Sorbent Traps Used To Sample Organic Constituents in Radioactive Waste Tank Vapor Headspace

    SciTech Connect

    Evans, John C. ); Huckaby, James L. ); Mitroshkov, Alexandre V. ); Julya, Janet L. ); Hayes, James C. ); Edwards, Jeffrey A.; Sasaki, Leela M.

    1997-11-01

    Two sampling methods[SUMMA polished canisters and triple sorbent traps (TSTs)] were compared for long-term storage of trace organic vapor samples collected from the headspaces of high-level radioactive waste tanks at the U.S. Department of Energy's Hanford Site in Washington State. Because safety, quality assurance, radiological controls, the long-term stability of the sampling media during storage needed to be addressed. Samples were analyzed with a gas chromatograph/mass spectrometer (GC/MS) using cryogenic reconcentration or thermal desorption sample introduction techniques. SUMMA canister samples were also analyzed for total non-methane organic compounds (TNMOC) by GC/flame ionization detector (FID) using EPA Compendium Method TO-12 . To verify the long-term stability of the sampling media, multiple samples were collected in parallel from a typical passively ventilated radioactive waste tank known to contain moderately high concentrations of both polar and nonpolar organic compounds. Analyses for organic analytes and TNMOC were conducted at increasing intervals over a 32-week period to determine whether any systematic degradation of sample integrity occurred. Analytes collected in the SUMMA polished canisters generally showed good stability over the full 32 weeks with recoveries at the 80% level or better for all compounds studied. The TST data showed some loss (50-80% recovery) for a few high-volatility compounds even in the refrigerated samples; losses for unrefrigerated samples were far more pronounced with recoveries as low as 20% observed in a few cases.

  16. Time-dependent magnetoelectric effect in Fe/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 heterostructure: A ferromagnetic resonance study

    NASA Astrophysics Data System (ADS)

    Zhao, Yue-Lei; Chen, Qian-Ping; Zhao, Yong-Gang; Pan, Liqing; Sun, Young

    2013-08-01

    Ferromagnetic resonance with applied electric fields has been used to investigate the magnetoelectric effect in a Fe/Pb(Mg1/3Nb2/3)0.7Ti0.3O3 heterostructure. The out-of-plane magnetoelectric effect follows a butterfly behavior in response to electric field, consistent with the linear piezoelectric strain-mediated mechanism. In contrast, the in-plane magnetoelectric effect exhibits a loop-like dependence on electric field. In addition, a relaxation of the in-plane resonant field has been observed after the ferroelectric domains are switched. The loop-like feature and the time-dependent response suggest that the in-plane magnetoelectric coupling involves the 109° switching and relaxation of ferroelectric domains.

  17. 32-week holding-time study of SUMMA polished canisters and triple sorbent traps used to sample organic constituents in radioactive waste tank vapor headspace

    SciTech Connect

    Evans, J.C.; Huckaby, J.L.; Mitroshkov, A.V.; Julya, J.L.; Hayes, J.C.; Edwards, J.A.; Sasaki, L.M.

    1998-11-01

    Two sampling methods [SUMMA polished canisters and triple sorbent traps (TSTs)] were compared for long-term storage of trace organic vapor samples collected from the headspaces of high-level radioactive waste tanks at the US Department of Energy`s Hanford Site in Washington State. The two methods were found to provide generally equivalent results. Because safety, quality assurance, radiological controls, and somewhat complex sample custody arrangements frequently precluded rapid analysis, the long-term stability of the sampling media during storage needed to be addressed. Samples were analyzed with a gas chromatograph/mass spectrometer (GC/MS) using cryogenic preconcentration or thermal desorption sample introduction techniques. SUMMA canister samples were also analyzed for total non-methane organic compounds (TNMOC) by GC/flame ionization detector (FID) using EPA Compendium Method TO-12. The 31 target organic analytes studied represented compounds with widely varying polarities and volatilities. To verify the long-term stability of the sampling media, multiple samples were collected in parallel from a typical passively ventilated radioactive waste tank known to contain moderately high concentrations of both polar and nonpolar organic compounds. Two sets of sorbent trap samples were collected to compare the effects of storage under refrigerated and room temperature conditions. Analyses for organic analytes and TNMOC were conducted at increasing intervals over a 32-week period to determine whether any systematic degradation of sample integrity occurred.

  18. My week: Marc Armour.

    PubMed

    2017-03-11

    Marc Armour, is a fourth-year vet student at the Royal Veterinary College. Now on rotations, he chose to spend a week doing EMS with the BVA's journals, which are published by BMJ. Here's how he got on.

  19. My week: Sara Robson.

    PubMed

    Robson, Sara

    2017-01-28

    Having an interest in government veterinary work, Cambridge fifth-year vet student Sara Robson jumped at the chance of spending a week with Defra to learn what it does and the job opportunities it offers.

  20. MotorWeek

    ScienceCinema

    None

    2016-07-12

    In 2008, PBS's MotorWeek, television's original automotive magazine, visited Argonne's Transportation Technology R&D Center "to learn what it really takes to make clean power sources a viable reality."

  1. MotorWeek

    SciTech Connect

    2009-01-01

    In 2008, PBS's MotorWeek, television's original automotive magazine, visited Argonne's Transportation Technology R&D Center "to learn what it really takes to make clean power sources a viable reality."

  2. 76 FR 43107 - Captive Nations Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... July 19, 2011 Part IV The President Proclamation 8692--Captive Nations Week, 2011 #0; #0; #0... Nations Week, 2011 By the President of the United States of America A Proclamation There are times in the... other achievements that have shaped our world. During Captive Nations Week, we remember the men...

  3. 78 FR 24321 - National Volunteer Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Documents#0;#0; ] Proclamation 8960 of April 19, 2013 National Volunteer Week, 2013 By the President of the... accept certain obligations to one another. National Volunteer Week is a time to renew that fundamentally... one. During National Volunteer Week, let us tap into that spirit once more. To find a...

  4. 76 FR 29139 - World Trade Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ...#0;#0; ] Proclamation 8677 of May 13, 2011 World Trade Week, 2011 By the President of the United... interdependent. World Trade Week is a time to highlight the vital connection between the global economy and the... hereby proclaim May 15 through May 21, 2011, as World Trade Week. I encourage all Americans to...

  5. Time-Resolved Laser Fluorescence Spectroscopy Study of the Coordination Chemistry of a Hydrophilic CHON [1,2,3-Triazol-4-yl]pyridine Ligand with Cm(III) and Eu(III).

    PubMed

    Wagner, Christoph; Mossini, Eros; Macerata, Elena; Mariani, Mario; Arduini, Arturo; Casnati, Alessandro; Geist, Andreas; Panak, Petra J

    2017-02-20

    The complexation of Cm(III) and Eu(III) with the novel i-SANEX complexing agent 2,6-bis[1-(propan-1-ol)-1,2,3-triazol-4-yl]pyridine (PTD) was studied by time-resolved laser fluorescence spectroscopy (TRLFS). The formation of 1:3, 1:2, and 1:1 metal/ligand complexes was identified upon increasing PTD concentration in 10(-3) mol/L HClO4 and in 0.44 mol/L HNO3 solutions. For all these complexes, stability constants were determined at different acid concentrations. Though under the extraction conditions proposed for an An/Ln separation process, that is, for 0.08 mol/L PTD in 0.44 mol/L HNO3, 1:3 complexes represent the major species, a significant fraction of 1:2 complexes was found. This is caused by ligand protonation, and results in lower Eu(III)/Am(III) separation factors compared to SO3-Ph-BTP, until now considered the i-SANEX reference ligand. Focused extraction studies performed at lower proton concentration, where the 1:3 complex is formed exclusively, confirm this assumption.

  6. One Week Every Year.

    ERIC Educational Resources Information Center

    LeBuffe, James R.

    1991-01-01

    Guidelines are offered to schools and communities for developing activities of a yearly Deaf Awareness Week. Topics covered should include general information about deafness; common myths and misunderstandings; information about sign languages; technologies available to deaf people; interpreting; and interaction among deaf and hearing students.…

  7. A Week of Observations

    ERIC Educational Resources Information Center

    Colasacco, Jenne

    2011-01-01

    Even the most effective teachers have room to grow, but it's not always easy for principals to give adequate guidance through short observations. High school principal Jenne Colasacco decided to bring more depth to her observations by observing each of her teachers during one class for an entire week. The new observation structure, which included…

  8. Swahili 12 Weeks Course.

    ERIC Educational Resources Information Center

    Defense Language Inst., Washington, DC.

    This 12-weeks course in basic Swahili comprises 55 lesson units in five volumes. The general course format consists of (1) perception drills for comprehension, oral production, and association using "situational picture" illustrations; (2) dialogs in English and Swahili, with cartoon guides; (3) sequenced pattern and recombination drills, and (4)…

  9. Phun Week: Understanding Physiology

    ERIC Educational Resources Information Center

    Limson, Mel; Matyas, Marsha Lakes

    2009-01-01

    Topics such as sports, exercise, health, and nutrition can make the science of physiology relevant and engaging for students. In addition, many lessons on these topics, such as those on the cardiovascular, respiratory, and digestive systems, align with national and state life science education standards. Physiology Understanding Week (PhUn…

  10. Arabic 12 Weeks Course.

    ERIC Educational Resources Information Center

    Defense Language Inst., Washington, DC.

    Volumes 1 and 2 (Lesson Units 1-55) of this beginning course in Arabic follow the Defense Language Institute format for intensive 12-week language courses, designed for native-speaker instructors using audiolingual methodology in the classroom. The third (and final) volume in this series constitutes a reference guide to pronunciation and grammar…

  11. A Week for Space

    ERIC Educational Resources Information Center

    Comstock, Diane

    2008-01-01

    Space Week focuses on concepts that enable students to make concrete observations in the early grades (K-2) and move to concepts that help students develop their internet research and writing skills in middle and upper grades (Grades 3-5), and culminates with the development of science investigation design skills (Grade 6). To help launch your…

  12. 1,2,3-Trichloropropane

    Integrated Risk Information System (IRIS)

    EPA / 635 / R - 08 / 010F www.epa.gov / iris TOXICOLOGICAL REVIEW OF 1,2,3 - TRICHLOROPROPANE ( CAS No . 96 - 18 - 4 ) In Support of Summary Information on the Integrated Risk Information System ( IRIS ) September 2009 U.S . Environmental Protection Agency Washington DC i DISCLAIMER This document ha

  13. Once weekly alendronate.

    PubMed

    Sambrook, Philip

    2003-05-01

    Alendronate, a bisphosphonate that potently inhibits bone resorption, has been shown in long-term clinical trials to be an effective treatment for osteoporosis, increasing bone mineral density and substantially reducing the incidence of both vertebral and nonvertebral fractures, including hip fractures, mostly using a daily dosage regimen. Although daily administration has generally been well tolerated in these trials, some patients develop upper gastrointestinal symptoms. Current safety and efficacy data suggest that once-weekly dosing of alendronate appears to be as efficacious as daily administration in the treatment of osteoporosis, providing greater convenience to patients, improved compliance and a lower risk of upper gastrointestinal symptoms compared with daily administration. This review examines published data addressing the safety and efficacy of once-weekly alendronate administration.

  14. Pregnancy Calendar: A Week-by-Week Guide

    MedlinePlus

    ... Feeding Your 1- to 2-Year-Old A Week-by-Week Pregnancy Calendar KidsHealth > For Parents > A Week-by-Week Pregnancy Calendar Print A A A en español ... place in your baby — and in you. Each week of pregnancy includes a description of your baby's ...

  15. Pregnancy Calendar: A Week-by-Week Guide

    MedlinePlus

    ... Feeding Your 1- to 2-Year-Old A Week-by-Week Pregnancy Calendar KidsHealth > For Parents > A Week-by-Week Pregnancy Calendar A A A en español Calendario ... place in your baby — and in you. Each week of pregnancy includes a description of your baby's ...

  16. Body composition changes in men and women after 2-3 weeks of bed rest

    NASA Technical Reports Server (NTRS)

    Pace, N.; Kodama, A. M.; Grunbaum, B. W.; Rahlmann, D. F.; Price, D. C.; Newsom, B. D.

    1976-01-01

    Several parameters of body composition were measured in eight men before and after 14 days of continuous recumbency, and in eight women before and after 17 days of recumbency. The parameters measured included body weight, body water, body potassium, plasma volume, and plasma protein concentrations. From these, values were derived for body fat content, lean body mass, body mass, and circulating plasma proteins. In general, the men and women responded similarly to continuous recumbency. Characteristically, there was significant reduction of plasma volume and body potassium in both groups. The women showed a significant reduction in circulating plasma protein, entirely in the albumin fraction; a similar change was observed in the men. The women, but not the men, showed a significant increase in circulating fibrinogen. Both men and women lost body cell mass, while body fat content remained the same or tended to increase slightly. It is expected that similar changes would occur in weightlessness. It is further concluded that women should tolerate the weightlessness of space flight physiologically as well as men.

  17. Time-Intensity Curves Obtained after Microbubble Injection Can Be Used to Differentiate Responders from Nonresponders among Patients with Clinically Active Crohn Disease after 6 Weeks of Pharmacologic Treatment.

    PubMed

    Quaia, Emilio; Sozzi, Michele; Angileri, Roberta; Gennari, Antonio Giulio; Cova, Maria Assunta

    2016-11-01

    Purpose To assess whether contrast material-enhanced ultrasonography (US) can be used to differentiate responders from nonresponders among patients with clinically active Crohn disease after 6 weeks of pharmacologic treatment. Materials and Methods This prospective study was approved by our ethics committee, and written informed consent was obtained from all patients. Fifty consecutive patients (26 men and 24 women; mean age, 34.76 years ± 9) with a proved diagnosis of active Crohn disease who were scheduled to begin therapy with biologics (infliximab or adalimumab) were included, with enrollment from June 1, 2013, to June 1, 2015. In each patient, the terminal ileal loop was imaged with contrast-enhanced US before the beginning and at the end of week 6 of pharmacologic treatment. Time-intensity curves obtained in responders (those with a decrease in the Crohn disease endoscopic index of severity score of 25-44 before treatment to 10-15 after treatment, an inflammatory score <7, and/or a decrease ≥70 in the Crohn disease activity index score compared with baseline) and nonresponders were compared with Mann-Whitney test. Results Responders (n = 31) and nonresponders (n = 19) differed (P < .05) in the percent change of peak enhancement (-40.78 ± 62.85 vs 53.21 ± 72.5; P = .0001), wash-in (-34.8 ± 67.72 vs 89.44 ± 145.32; P = .001) and washout (-5.64 ± 130.71 vs 166.83 ± 204.44; P = .002) rate, wash-in perfusion index (-42.29 ± 59.21 vs 50.96 ± 71.13; P = .001), area under the time-intensity curve (AUC; -46.17 ± 48.42 vs 41.78 ± 87.64; P = .001), AUC during wash-in (-43.93 ± 54.29 vs 39.79 ± 70.85; P = .001), and AUC during washout (-49.36 ± 47.42 vs 42.65 ± 97.09; P = .001). Responders and nonresponders did not differ in the percent change of rise time (5.09 ± 49.13 vs 6.24 ± 48.06; P = .93) and time to peak enhancement (8.82 ± 54.5 vs 10.21 ± 43.25; P = .3). Conclusion Analysis of time-intensity curves obtained after injection of microbubble

  18. Longer dialysis session length is associated with better intermediate outcomes and survival among patients on in-center three times per week hemodialysis: results from the Dialysis Outcomes and Practice Patterns Study (DOPPS)

    PubMed Central

    Tentori, Francesca; Zhang, Jinyao; Li, Yun; Karaboyas, Angelo; Kerr, Peter; Saran, Rajiv; Bommer, Juergen; Port, Friedrich; Akiba, Takashi; Pisoni, Ronald; Robinson, Bruce

    2012-01-01

    Background Longer dialysis session length (treatment time, TT) has been associated with better survival among hemodialysis (HD) patients. The impact of TT on clinical markers that may contribute to this survival advantage is not well known. Methods Using data from the international Dialysis Outcomes and Practice Patterns Study, we assessed the association of TT with clinical outcomes using both standard regression analyses and instrumental variable approaches. The study included 37 414 patients on in-center HD three times per week with prescribed TT from 120 to 420 min. Results Facility mean TT ranged from 214 min in the USA to 256 min in Australia–New Zealand. Accounting for country effects, mortality risk was lower for patients with longer TT {hazard ratio for every 30 min: all-cause mortality: 0.94 [95% confidence interval (CI): 0.92–0.97], cardiovascular mortality: 0.95 (95% CI: 0.91–0.98) and sudden death: 0.93 (95% CI: 0.88–0.98)}. Patients with longer TT had lower pre- and post-dialysis systolic blood pressure, greater intradialytic weight loss, higher hemoglobin (for the same erythropoietin dose), serum albumin and potassium and lower serum phosphorus and white blood cell counts. Similar associations were found using the instrumental variable approach, although the positive associations of TT with weight loss and potassium were lost. Conclusions Favorable levels of a variety of clinical markers may contribute to the better survival of patients receiving longer TT. These findings support longer TT prescription in the setting of in-center, three times per week HD. PMID:22431708

  19. Adalimumab treatment optimization for psoriasis: Results of a long-term phase 2/3 Japanese study.

    PubMed

    Asahina, Akihiko; Ohtsuki, Mamitaro; Etoh, Takafumi; Gu, Yihua; Okun, Martin M; Teixeira, Henrique D; Yamaguchi, Yuji; Nakagawa, Hidemi

    2015-11-01

    The tumor necrosis factor-α inhibitor, adalimumab, is approved to treat moderate-to-severe plaque psoriasis (40 mg every-other-week or 80 mg every-other-week following inadequate response at 40 mg in Japan). This open-label extension (OLE) trial evaluated the optimal adalimumab dose for long-term efficacy and safety in Japanese patients with moderate-to-severe plaque psoriasis following a prior 24-week, phase 2/3, randomized, double-blind study. Of the 169 patients from the phase 2/3 trial, 147 entered the OLE on 40 mg (n = 89) or 80 mg (n = 58) adalimumab every-other-week. Patients on 40 mg with Psoriasis Area and Severity Index (PASI) of less than 50 could escalate to 80 mg. At week 52 (28 of OLE), patients entering the OLE on 80 mg were reduced to 40 mg, with the option to re-escalate. For patients entering the OLE on 40 mg, final PASI 50/75/90 response rates were 85.1%/73.3%/60.4%, respectively, including effects of dose escalation. Among patients whose dose was escalated, final PASI 50/75/90 response rates were 70.0%/53.3%/36.7%, respectively. For patients entering the OLE on 80 mg, final PASI 50/75/90 response rates were 92.5%/84.9%/73.6%, respectively, including effects of dose re-escalation. Overall incidence rates of adverse events (AE) and injection-site reaction AE declined over time; rates for serious AE and infections were generally stable. Clinically meaningful efficacy of adalimumab was sustained to 4 years. Dose escalation to 80 mg every-other-week for patients with suboptimal response to 40 mg every-other-week, and dose reduction to 40 mg every-other-week for patients satisfactorily controlled on 80 mg every-other-week, are viable strategies for adalimumab optimization.

  20. Elective Delivery Before 39 Weeks

    MedlinePlus

    ... Delivery, and Postpartum Care Elective Delivery Before 39 Weeks • What is a “medically indicated” delivery? • What is ... the baby grow and develop during the last weeks of pregnancy? • What are the risks for babies ...

  1. The Iceman's last weeks

    NASA Astrophysics Data System (ADS)

    Spindler, Konrad

    1994-06-01

    The author presents the archaeological, botanical and anatomical of medical evidence relating to the events of the last few days of the Iceman's life. The unfinished arrows and the half-completed bow indicate that he had lost his weapons and was in the process of re-arming himself. The quiver and the two primed arrows show clear signs of damage that has been proved to originate from before entombment in the ice of Hauslabjoch. An intravital series of fractured ribs and atrophic changes to the humerus on the same side of the body are also indicative of a violent conflict. The presence of threshing and winnowing fragments proves that, shortly before his death, the Iceman spent some time in a human settlement in which the grain crop was threshed. The theory is therefore proposed that shortly before his death the Iceman suffered some personal catastrophe involving damage to his possessions and physical injury. He fled in the direction of the inner Ötz Valley, a region of high alpine pastures he may have been familiar with from summer transhumance. Just beyond the ridge of the main Alpine chain he was caught by a sudden fall in temperature and snowfall, which he did not survive.

  2. 43 CFR 3190.2-3 - Audit.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Audit. 3190.2-3 Section 3190.2-3 Public... and Gas Inspections: General § 3190.2-3 Audit. In maintaining financial records relating to the funds... tribes and contractors shall comply with generally accepted accounting principles and audit...

  3. 43 CFR 3190.2-3 - Audit.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Audit. 3190.2-3 Section 3190.2-3 Public... and Gas Inspections: General § 3190.2-3 Audit. In maintaining financial records relating to the funds... tribes and contractors shall comply with generally accepted accounting principles and audit...

  4. 43 CFR 3190.2-3 - Audit.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Audit. 3190.2-3 Section 3190.2-3 Public... and Gas Inspections: General § 3190.2-3 Audit. In maintaining financial records relating to the funds... tribes and contractors shall comply with generally accepted accounting principles and audit...

  5. 43 CFR 3190.2-3 - Audit.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Audit. 3190.2-3 Section 3190.2-3 Public... and Gas Inspections: General § 3190.2-3 Audit. In maintaining financial records relating to the funds... tribes and contractors shall comply with generally accepted accounting principles and audit...

  6. 39 CFR 2.3 - Offices.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Offices. 2.3 Section 2.3 Postal Service UNITED... (ARTICLE II) § 2.3 Offices. The principal office of the Postal Service is located in Washington, DC, with such regional and other offices and places of business as the Postmaster General establishes from...

  7. 45 CFR 1206.2-3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Definitions. 1206.2-3 Section 1206.2-3 Public Welfare Regulations Relating to Public Welfare (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE GRANTS AND CONTRACTS-SUSPENSION AND TERMINATION AND DENIAL OF APPLICATION FOR REFUNDING Denial of Application for Refunding § 1206.2-3...

  8. 39 CFR 2.3 - Offices.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 39 Postal Service 1 2012-07-01 2012-07-01 false Offices. 2.3 Section 2.3 Postal Service UNITED STATES POSTAL SERVICE THE BOARD OF GOVERNORS OF THE U.S. POSTAL SERVICE GENERAL AND TECHNICAL PROVISIONS (ARTICLE II) § 2.3 Offices. The principal office of the Postal Service is located in Washington, DC,...

  9. 43 CFR 2916.2-3 - Renewal of leases.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) LEASES Alaska Fur Farm § 2916.2-3 Renewal of... preference right to a renewal. The timely filing of an application will, however authorize the exclusive...

  10. 43 CFR 2916.2-3 - Renewal of leases.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) LEASES Alaska Fur Farm § 2916.2-3 Renewal of... preference right to a renewal. The timely filing of an application will, however authorize the exclusive...

  11. 43 CFR 2916.2-3 - Renewal of leases.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) LEASES Alaska Fur Farm § 2916.2-3 Renewal of... preference right to a renewal. The timely filing of an application will, however authorize the exclusive...

  12. 43 CFR 2916.2-3 - Renewal of leases.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) LEASES Alaska Fur Farm § 2916.2-3 Renewal of... preference right to a renewal. The timely filing of an application will, however authorize the exclusive...

  13. Effect of glatiramer acetate three-times weekly on the evolution of new, active multiple sclerosis lesions into T1-hypointense "black holes": a post hoc magnetic resonance imaging analysis.

    PubMed

    Zivadinov, Robert; Dwyer, Michael; Barkay, Hadas; Steinerman, Joshua R; Knappertz, Volker; Khan, Omar

    2015-03-01

    Conversion of active lesions to black holes has been associated with disability progression in subjects with relapsing-remitting multiple sclerosis (RRMS) and represents a complementary approach to evaluating clinical efficacy. The objective of this study was to assess the conversion of new active magnetic resonance imaging (MRI) lesions, identified 6 months after initiating treatment with glatiramer acetate 40 mg/mL three-times weekly (GA40) or placebo, to T1-hypointense black holes in subjects with RRMS. Subjects received GA40 (n = 943) or placebo (n = 461) for 12 months. MRI was obtained at baseline and Months 6 and 12. New lesions were defined as either gadolinium-enhancing T1 or new T2 lesions at Month 6 that were not present at baseline. The adjusted mean numbers of new active lesions at Month 6 converting to black holes at Month 12 were analyzed using a negative binomial model; adjusted proportions of new active lesions at Month 6 converting to black holes at Month 12 were analyzed using a logistic regression model. Of 1,292 subjects with complete MRI data, 433 (50.3 %) GA-treated and 247 (57.2 %) placebo-treated subjects developed new lesions at Month 6. Compared with placebo, GA40 significantly reduced the mean number (0.31 versus 0.45; P = .0258) and proportion (15.8 versus 19.6 %; P = .006) of new lesions converting to black holes. GA significantly reduced conversion of new active lesions to black holes, highlighting the ability of GA40 to prevent tissue damage in RRMS.

  14. Dielectric properties of polyfunctional alcohols: 2,3-butanediol

    NASA Astrophysics Data System (ADS)

    Zhuravlev, V. I.

    2016-08-01

    Using a variety theoretical approaches within the Debye, Davidson-Cole, and Forsman models, and an approach based on the Dissado-Hill theory, dielectric spectra of 2,3-butanediol in the temperature range of 298 to 423 K are analyzed. It is shown that the dielectric spectra of 2,3-butanediole are described by the Davidson-Cole equation, and the βDC parameter depends strongly on temperature. The spectrum of dielectric relaxation of 2,3-butanediol within the Debye theory is presented as the sum of two areas of dispersion, and conclusions are drawn regarding possible mechanisms of dispersion responsible for the obtained fields. The relaxation times of 2,3-butanediol, calculated using different equations describing the nonlinear behavior of relaxation times, are compared. The dipole moments of clusters are obtained for the first time using the Dissado-Hill cluster model, and a preliminary analysis of them is performed.

  15. Adult Learners' Week in Australia.

    ERIC Educational Resources Information Center

    Cross, John

    2002-01-01

    Promotional materials and activities for Australia's Adult Learners Week, which are shaped by a variety of stakeholders , include media strategies and a website. Activities are evaluated using a market research company and website and telephone hotline statistics. (SK)

  16. Fluorination of 1,2,3,4- and 1,2,3,5-tetrahalobenzenes with potassium fluoride in dimethyl sulfone

    USGS Publications Warehouse

    Finger, G.C.; Dickerson, D.R.; Shiley, R.H.

    1972-01-01

    1,2,3,4-Tetrachlorobenzene, 1,2,3,5-tetrachlorobenzene, 2,4,6-trichlorofluorobenzene, and 2,6-dichloro-1,4-difluorobenzene were fluorinated with potassium fluoride and potassium fluoride-cesium fluoride mixtures in dimethyl sulfone. By varying the concentration, temperature and reaction time, the degree of fluorination could be controlled to some extent. The optimum conditions for producing mono-, di- and tri-fluoro-substituted chlorobenzenes and trace amounts of tetrafluorobenzene from the corresponding tetrachlorobenzenes are given. 1,2,3,5-Tetrafluorobenzene was obtained in 44.8% yield from 2,6-dichloro-1,4-difluorobenzene. 1,2,3,4-Tetrafluorobenzene was obtained in only trace amounts from 1,2,3,4-tetrachlorobenzene. A total of 24 new chlorofluorobenzenes and intermediates are described. Fluorination with potassium fluoride and certain other metal fluorides was also investigated. ?? 1972.

  17. A phase I study with MAG-camptothecin intravenously administered weekly for 3 weeks in a 4-week cycle in adult patients with solid tumours.

    PubMed

    Wachters, F M; Groen, H J M; Maring, J G; Gietema, J A; Porro, M; Dumez, H; de Vries, E G E; van Oosterom, A T

    2004-06-14

    In MAG-camptothecin (MAG-CPT), the topoisomerase inhibitor camptothecin is linked to a water-soluble polymer. Preclinical experiments showed enhanced antitumour efficacy and limited toxicity compared to camptothecin alone. Prior phase I trials guided the regimen used in this study. The objectives were to determine the maximum tolerated dose, dose-limiting toxicities, safety profile, and pharmacokinetics of weekly MAG-CPT. Patients with solid tumours received MAG-CPT intravenously administered weekly for 3 weeks in 4-week cycles. At the starting dose level (80 mg x m(-2) week(-1)), no dose-limiting toxicities occurred during the first cycle (n=3). Subsequently, three patients were enrolled at the second dose level (120 mg x m(-2) week(-1)). Two of three patients at the 80 mg x m(-2) week(-1) cohort developed haemorrhagic cystitis (grade 1/3 dysuria and grade 2/3 haematuria) during the second and third cycles. Next, the 80 mg x m(-2) week(-1) cohort was enlarged to a total of six patients. One other patient at this dose level experienced grade 1 haematuria. At 120 mg x m(-2) week(-1), grade 1 bladder toxicity occurred in two of three patients. Dose escalation was stopped at 120 mg x m(-2) week(-1). Cumulative bladder toxicity was dose-limiting toxicity at 80 mg x m(-2) week(-1). Pharmacokinetics revealed highly variable urinary camptothecin excretion, associated with bladder toxicity. Due to cumulative bladder toxicity, weekly MAG-CPT is not a suitable regimen for treatment of patients with solid tumours.

  18. 75 FR 10993 - Save Your Vision Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... Documents#0;#0; ] Proclamation 8483 of March 5, 2010 Save Your Vision Week, 2010 By the President of the... treatment of eye conditions. Save Your Vision Week is a time for all Americans to take action to protect... household chores and yard work. This week, I encourage all Americans to visit the National Eye...

  19. 76 FR 65095 - National Character Counts Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... Counts Week, 2011 By the President of the United States of America A Proclamation In times of adversity... humanity. During National Character Counts Week, we celebrate our country's core values and commit to... week, we resolve to stay true to the American spirit and live according to our highest ideals....

  20. Dad’s Last Week

    PubMed Central

    DeVoe, Jennifer E.

    2016-01-01

    I had intended to spend our spring break week in Montana with my kids and my dad, going to parks and museums together. Instead, I spent the week in the hospital, helping my dad make end-of-life choices and learning more about the importance of communication in health care settings and the preciousness of close relationships in life. I am a better person and a better physician because my dad trusted me to be there while he was dying. During his last week, I was grateful to have spent years studying medicine and years getting to know my dad. This combination of professional and personal knowledge enabled me to help him choose his own end-of-life path. As someone who does not like hospitals, I have always wondered why I became a doctor; now I know. PMID:27185000

  1. Portuguese Special Course: 12 Weeks.

    ERIC Educational Resources Information Center

    Defense Language Inst., Washington, DC.

    This 12-week course in beginning Portuguese comprises four volumes of student text (Lessons 1-55) and a fifth volume of Portuguese-English/English-Portuguese vocabulary. Lesson materials consist of basic dialogs with English translation, recombination dialogs, readings and comprehension questions, oral exercises, and in later units, additional…

  2. HPF Implementation of NPB2.3

    NASA Technical Reports Server (NTRS)

    Frumkin, Michael; Jin, Hao-Qiang; Yan, Jerry; Saini, Subhash (Technical Monitor)

    1998-01-01

    We present the HPF implementation of BT, SP, LU, FT, and MG of NPB2.3-serial benchmark set, The implementation is based on HPF performance model of the benchmark specific operations with distributed arrays. We present profiling and performance data on SGI origin 2000 and compare the results with NPB2.3. We discuss advantages and limitations of HPF and pghpf compiler.

  3. Metabotropic glutamate2/3 receptor agonism facilitates autonomic recovery after pharmacological panic challenge in healthy humans.

    PubMed

    Agorastos, Agorastos; Demiralay, Cüneyt; Stiedl, Oliver; Muhtz, Christoph; Wiedemann, Klaus; Kellner, Michael

    2016-05-01

    Group II metabotropic glutamate receptors (mGluR2/3) are suggested to modulate anxiety, arousal, and stress including autonomic control. However, no study has investigated mGluR2/3-related effects on baseline autonomic activity and reactivity to emotional challenge in humans as yet. Using a double-blind, randomized placebo-controlled, cross-over study design, we investigated the influence of a 1-week treatment with the mGluR2/3 agonist LY544344, prodrug of LY354740, on autonomic reactivity to a cholecystokinin tetrapeptide (CCK-4) panic challenge in eight healthy young men. The main outcome measures were time and frequency domain heart rate variability parameters during baseline, CCK-4 challenge, and recovery. There was no evidence for LY544344-mediated effects on baseline and CCK-4 challenge vagal activity, but a significantly lower recovery low frequency (%) and low frequency/high frequency ratio in the LY544344 group, suggesting enhanced autonomic recovery. This pilot study provides first human data indicating that mGluR2/3 agonism is involved in autonomic responsiveness, suggesting an important role of mGluR2/3 in central autonomic regulation.

  4. Local gene therapy with indoleamine 2,3-dioxygenase protects against development of transplant vasculopathy in chronic kidney transplant dysfunction.

    PubMed

    Vavrincova-Yaghi, D; Deelman, L E; van Goor, H; Seelen, M A; Vavrinec, P; Kema, I P; Gomolcak, P; Benigni, A; Henning, R H; Sandovici, M

    2016-11-01

    Chronic transplant dysfunction (CTD) is the primary cause of late allograft loss in kidney transplantation. Indoleamine 2,3-dioxygenase (IDO) is involved in fetomaternal tolerance and IDO gene therapy inhibits acute rejection following kidney transplantation. The aim of this study is to investigate whether gene therapy with IDO is able to attenuate CTD. Transplantation was performed in a rat Dark-Agouti to Wistar-Furth CTD model. Donor kidneys were incubated either with an adenovirus carrying IDO gene, a control adenovirus or saline. During the first 10 days recipients received low-dose cyclosporine. Body weight, blood pressure, serum creatinine and proteinuria were measured every 2 weeks. Rats were killed after 12 weeks. IDO had a striking beneficial effect on transplant vasculopathy at week 12. It also significantly improved body weight gain; it reduced blood pressure and decreased proteinuria during the follow-up. However, it did not affect the kidney function. In addition, IDO therapy significantly decreased the number of graft-infiltrating macrophages at week 12. The messenger RNA levels of forkhead box p3 and transforming grow factor-β were elevated in the IDO treated group at week 12. Here we show for first time a clear beneficial effect of local IDO gene therapy especially on transplant vasculopathy in a rat model of renal CTD.

  5. Astronomy Week in Madeira, Portugal

    NASA Astrophysics Data System (ADS)

    Augusto, P.; Sobrinho, J. L.

    2012-05-01

    The outreach programme Semanas da Astronomia (Astronomy Weeks) is held in late spring or summer on the island of Madeira, Portugal. This programme has been attracting enough interest to be mentioned in the regional press/TV/radio every year and is now, without doubt, the astronomical highlight of the year on Madeira. We believe that this programme is a good case study for showing how to attract the general public to astronomy in a small (population 250 000, area 900 km2) and fairly isolated place such as Madeira. Our Astronomy Weeks have been different each year and have so far included exhibitions, courses, talks, a forum, documentaries, observing sessions (some with blackouts), music and an astro party. These efforts may contribute towards putting Madeira on the map with respect to observational astronomy, and have also contributed to the planned installation of two observatories in the island.

  6. Six Week Slavery Novel Unit.

    ERIC Educational Resources Information Center

    Jones, Darolyn Lyn

    Developed in conjunction with a graduate course and used in classrooms with all types of learners, this paper presents a 6-week unit of study on slavery based on two adolescent novels--"NIGHTJOHN" by Gary Paulson and "My Name Is not Angelica" by Scott O'Dell. After a brief introduction to the unit, the paper presents the 14 activities of the unit:…

  7. 2,3,4,6-Tetrachlorophenol

    Integrated Risk Information System (IRIS)

    2,3,4,6 - Tetrachlorophenol ; CASRN 58 - 90 - 2 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncar

  8. 1,2,3-triazolium ionic liquids

    SciTech Connect

    Luebke, David; Nulwala, Hunaid; Tang, Chau

    2014-12-09

    The present invention relates to compositions of matter that are ionic liquids, the compositions comprising substituted 1,2,3-triazolium cations combined with any anion. Compositions of the invention should be useful in the separation of gases and, perhaps, as catalysts for many reactions.

  9. New 2-aryl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-4-one derivatives as diuretics.

    PubMed

    Monge, A; Martinez-Merino, V; Simon, M A; Sanmartin, C

    1993-12-01

    2-Aryl-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-4-one derivatives having various substituents at the 4'-position, H or methyl at 1,3-positions and nitro or amino at 6-position were prepared and tested for their diuretic, natriuretic and kaliuretic activities on male Wistar rats at a dosage of 25 mg/kg or less. 2-(3-Pyridyl) derivatives were inactive. 1,3-Dimethyl-6-nitro-2-phenyl derivatives (1) were active depending on the electronic character of the 4'-substituent but at the same time were sodium-sparing. However, 1(H),3(H)-6-nitro-2-phenyl derivatives (2) were generally inactive as diuretics but active as potassium-sparing drugs. 6-Amino-1(H),3(H)-2-phenyl derivatives (4) were active as diuretics depending on dipolar moment of the substituent at the 4'-position, and induced moderate potassium release. The 6-amino-2-(4-trifluoromethylphenyl)-1, 2,3,4-tetrahydropyrido [2,3-d]pyrimidin-4-one (4f) remained active up to a dosage of 3 mg/kg. The structure-activity relationships were carried out in light of the adaptative least squares (ALS) method and discriminant functions for diuretic compounds were established.

  10. Lesson Planning for Once-Per-Week Spanish

    ERIC Educational Resources Information Center

    Smrokowski, Linda

    2005-01-01

    Although she is now teaching Spanish in a new school full time, Linda Smrokowski, spent 9 years teaching in a once-per-week second language program. Because many once- or twice-per-week programs still exist, she shares strategies for writing and implementing detailed lesson plans that worked for her while she was teaching in a once-per-week…

  11. "Mid-Week Pictorial": Pioneer American Photojournalism Magazine.

    ERIC Educational Resources Information Center

    Kenney, Keith

    In 1914 (22 years before the inception of "Life" magazine), the "New York Times" began publishing "Mid-Week Pictorial" to absorb a flood of war pictures pouring in from Europe. Several sociological and technological forces shaped "Mid-Week Pictorial" as a pioneer of American photojournalism magazines,…

  12. 77 FR 31151 - World Trade Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... 8827 of May 21, 2012 World Trade Week, 2012 By the President of the United States of America A... services designed and produced by Americans. During World Trade Week, we reaffirm the essential role... Week. I encourage all Americans to observe this week with events, trade shows, and educational...

  13. 75 FR 20885 - National Park Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... Proclamation 8498--National Park Week, 2010 Proclamation 8499--National Crime Victims' Rights Week, 2010 Proclamation 8500--National Volunteer Week, 2010 Proclamation 8501--National Day of Service and Remembrance for... President ] Proclamation 8498 of April 16, 2010 National Park Week, 2010 By the President of the...

  14. SO(2, 3) noncommutative gravity model

    NASA Astrophysics Data System (ADS)

    Dimitrijević, M.; Radovanović, V.

    2014-12-01

    In this paper the noncommutative gravity is treated as a gauge theory of the non-commutative SO(2, 3)★ group, while the noncommutativity is canonical. The Seiberg-Witten (SW) map is used to express noncommutative fields in terms of the corresponding commutative fields. The commutative limit of the model is the Einstein-Hilbert action plus the cosmological term and the topological Gauss-Bonnet term. We calculate the second order correction to this model and obtain terms that are zeroth, first, ... and fourth power of the curvature tensor. Finally, we discuss physical consequences of those correction terms in the limit of big cosmological constant.

  15. The Four Day School Week. Research Brief

    ERIC Educational Resources Information Center

    Muir, Mike

    2013-01-01

    Can four-day school weeks help districts save money? How do districts overcome the barriers of moving to a four-day week? What is the effect of a four-day week on students, staff and the community? This paper enumerates the benefits for students and teachers of four-day school weeks. Recommendations for implementation of a four-day week are also…

  16. Subsidence at the Weeks Island SPR Facility

    SciTech Connect

    Bauer, S.J.

    1999-01-01

    The elevation change data measured at the Weeks Island SPR site over the last 16+ years has been studied and analyzed. The subsidence rate is not constant with time and while the subsidence rate may have increased slightly during the past several years, recently the rate has increased more dramatically. The most recent increase comes at a time when the Strategic Petroleum Reserve (SPR) storage mine had been emptied of oil and was in the process of being refilled with brine. Damage to surface structures that has been observed during the past 12-18 months is attributed to the continued subsidence and dtierential subsidence across structures. The recent greater subsidence rates were unanticipated according to analysis results and will be used to aid further subsidence model development.

  17. The 4 Day School Week

    ERIC Educational Resources Information Center

    Dam, Ai

    2006-01-01

    Colorado law requires school districts to schedule 1080 hours per year of instructional time for secondary schools and 990 instructional hours for elementary schools. The 1080 hours equate to six hours per day for 180 days. The 990 hours equate to five and one-half hours per day. Up to 24 hours may be counted for parent-teacher conferences, staff…

  18. Uterine artery impedance during the first eight postpartum weeks

    PubMed Central

    Guedes-Martins, L.; Gaio, A. R.; Saraiva, J.; Cunha, A.; Macedo, F.; Almeida, H.

    2015-01-01

    The aim of this study was to construct reference ranges for the uterine artery (UtA) mean pulsatility (PI) and resistance (RI) indices from 1–8 weeks postpartum. A prospective, cross-sectional, and observational study was performed with 320 healthy women from week 1 through week 8 postpartum. UtAs were examined transvaginally using colour and pulsed Doppler imaging, and the means of the right and left values of the PI and RI, as well as the presence or absence of a bilateral protodiastolic notch, were recorded. The 5th, 50th and 95th reference percentile curves for the UtA-PI and UtA-RI were derived using regression models. The adjusted reference intervals uncovered a convergence trend at the week 8 time-point, although impedance was lower at the week 1 time-point in multiparous women compared with primiparous women. The notching prevalence was 22.5% (9/40) at week 1 and 95.0% (38/40) at week 8. The study revealed consistent evidence of a progressive increase of postpartum uterine impedance and provided new average UtA-PI and UtA-RI reference charts for weeks 1 through 8. Multiparity does not change the trend but does impart a lower rate of increase, likely as a consequence of previous vascular structural and functional differences. PMID:25739463

  19. 76 FR 63801 - Fire Prevention Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-13

    ... Part IV The President Proclamation 8732--Fire Prevention Week, 2011 Proclamation 8733--National School Lunch Week, 2011 Proclamation 8734--Leif Erikson Day, 2011 Proclamation 8735--Columbus Day, 2011...;Title 3-- #0;The President [[Page 63803

  20. 76 FR 72601 - National Family Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... Part IV The President Proclamation 8756--National Family Week, 2011 Proclamation 8757--National Farm-City Week, 2011 Proclamation 8758--National Child's Day, 2011 Executive Order 13590--Authorizing the...-- #0;The President [[Page 72603

  1. 1,2,3-Trichloropropane: a multisite carcinogen in rats and mice.

    PubMed

    Irwin, R D; Haseman, J K; Eustis, S L

    1995-05-01

    1,2,3-Trichloropropane was evaluated in 2-year toxicology and carcinogenesis studies by the National Toxicology Program. The selection of this chemical for study was based on the potential for human exposure, its positive in vitro genotoxicity, and the carcinogenicity of structurally related chemicals. During the 2-year study 1,2,3-trichloropropane was administered in corn oil by gavage 5 days per week; groups of 60 F344/N rats received 0, 3, 10, or 30 mg/kg, while groups of 60 B6C3F1 mice received 0,6,20, or 60 mg/kg. Because of reduced survival associated with the development of chemical-related neoplasms, rats that received 30 mg/kg were terminated at 65 weeks (females) or 76 weeks (males). Similarly, mice that received 60 mg/kg were terminated at 73 weeks (females) or 79 weeks (males), while groups of mice that received 20 mg/kg were terminated at 88 weeks. 1,2,3-Trichloropropane induced benign and/or malignant neoplasms at multiple sites in both rats and mice; this included increased incidences of benign and malignant neoplasms of the squamous epithelium of the oral mucosa and forestomach of male and female rats, benign neoplasms of the kidney and pancreas and benign or malignant neoplasms of the preputial gland in male rats, malignant neoplasms of the mammary gland, and benign or malignant neoplasms of the clitoral gland in female rats. In mice, 1,2,3-trichloropropane induced a low incidence of malignant neoplasms of the oral mucosa in females, high incidences of benign and malignant neoplasms of the forestomach in males and females, benign neoplasms of the liver and harderian gland of males and females, and uterine neoplasms in females.

  2. 78 FR 44867 - Captive Nations Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-24

    ... July 24, 2013 Part VI The President Proclamation 8998--Captive Nations Week, 2013 #0; #0; #0... Nations Week, 2013 By the President of the United States of America A Proclamation As citizens of the... privileged few. Captive Nations Week is an opportunity to reaffirm America's role in advancing human...

  3. 76 FR 28623 - Small Business Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-18

    ... Documents#0;#0; #0; #0;Title 3-- #0;The President ] Proclamation 8673 of May 12, 2011 Small Business Week... to work hard enough, you can succeed in our country. This week, we honor and celebrate the... of the United States, do hereby proclaim May 15 through May 21, 2011, as Small Business Week. I...

  4. Understanding Infidelity: An Interview with Gerald Weeks

    ERIC Educational Resources Information Center

    Smith, Travis

    2011-01-01

    In this interview, Gerald Weeks shares his expertise on the topic of infidelity and couples counseling. Dr. Weeks defines infidelity, presents assessment strategies for treating the issue of infidelity, and discusses an intersystemic model for infidelity treatment when counseling couples. Dr. Weeks also provides insight into common mistakes made…

  5. 75 FR 29393 - Small Business Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ... 8525 of May 20, 2010 Small Business Week, 2010 By the President of the United States of America A.... During Small Business Week, we reaffirm our support for America's small businesses and celebrate the... that have helped small business owners acquire loans and hire workers. This week, we celebrate the...

  6. 77 FR 22177 - National Volunteer Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... April 12, 2012 Part III The President Proclamation 8797--National Volunteer Week, 2012 Proclamation 8798--Pan American Day and Pan American Week, 2012 Proclamation 8799--National Former Prisoner of War... 8797 of April 9, 2012 National Volunteer Week, 2012 By the President of the United States of America...

  7. 77 FR 68045 - American Education Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-15

    ... Documents#0;#0; ] Proclamation 8904 of November 9, 2012 American Education Week, 2012 By the President of... Nation's economic prosperity and civic life. This week, we reaffirm our national mission of educating our... will take you. During American Education Week, we recommit to keeping the promise of education...

  8. 78 FR 71431 - National Family Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... November 27, 2013 Part V The President Proclamation 9061--National Family Week, 2013 #0; #0; #0... National Family Week, 2013 By the President of the United States of America A Proclamation Whether united... guardian--families are the building blocks of American society. During National Family Week, we...

  9. 78 FR 69749 - American Education Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-20

    ... November 20, 2013 Part II The President Proclamation 9058--American Education Week, 2013 #0; #0; #0... American Education Week, 2013 By the President of the United States of America A Proclamation Education is... Education Week, we reaffirm our commitment to the next generation, and we celebrate everyone who is...

  10. 75 FR 71519 - National Family Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... Week, 2010 By the President of the United States of America A Proclamation Like generations before them... Family Week, we celebrate the resilient spirit of America's families and their role in building vibrant... loved ones safe here at home and abroad. This National Family Week, we recognize the importance of...

  11. 76 FR 22001 - National Park Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... Documents#0;#0; ] Proclamation 8656 of April 15, 2011 National Park Week, 2011 By the President of the.... ``Healthy Parks, Healthy People,'' the focus for this year's National Park Week, highlights the role of... waived during National Park Week. All Americans can visit www.NPS.gov to find nearby parks where...

  12. 78 FR 24323 - National Park Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Documents#0;#0; ] Proclamation 8961 of April 19, 2013 National Park Week, 2013 By the President of the... be passed on. During National Park Week, we celebrate the wonders entrusted to us by our forebears..., and they summon us to experience it firsthand. This week, the National Park Service will make...

  13. 77 FR 69733 - National Family Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-21

    ... Week, 2012 By the President of the United States of America A Proclamation The bonds that tie us to our... strength of character in their children. This week, we celebrate the unity and compassion that keep our... opportunity for all who are working hard to get ahead. During National Family Week, let us recommit to...

  14. 78 FR 30729 - World Trade Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... Documents#0;#0; ] Proclamation 8983 of May 17, 2013 World Trade Week, 2013 By the President of the United... Week, we recognize workers, growers, and entrepreneurs nationwide who share that ambition, and we... United States, do hereby proclaim May 19 through May 25, 2013, as World Trade Week. I encourage...

  15. 76 FR 20215 - National Volunteer Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... Week, 2011 By the President of the United States of America A Proclamation America's story has been... they see a need. During National Volunteer Week, we celebrate the profound impact of volunteers and... April 10 through April 16, 2011, as National Volunteer Week. I call upon all Americans to observe...

  16. 75 FR 71005 - American Education Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-22

    ... Education Week, 2010 By the President of the United States of America A Proclamation Education is essential to our success as both a people and a Nation. During American Education Week, we rededicate ourselves..., career, and life. This week, let us reaffirm the importance of education and recognize that we all...

  17. 75 FR 42279 - Captive Nations Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... Documents#0;#0; #0; #0;Title 3-- #0;The President ] Proclamation 8541 of July 16, 2010 Captive Nations Week... and requested the President to issue a proclamation designating the third week of July of each year as ``Captive Nations Week.'' NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America,...

  18. 75 FR 28183 - World Trade Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-20

    ...#0;#0; ] Proclamation 8521 of May 12, 2010 World Trade Week, 2010 By the President of the United.... World Trade Week is an opportunity for us to reaffirm the importance of trade to our Nation's continued... been forged through decades of hard work, ingenuity, optimism, and common purpose. This week, let...

  19. 77 FR 24575 - National Park Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... Documents#0;#0; #0; #0;Title 3-- #0;The President ] Proclamation 8801 of April 20, 2012 National Park Week... National Park Week, all 397 National Parks will offer free admission from April 21 through April 29, 2012... as our National Parks.'' This week, we honor the uniquely American idea behind them: that each of...

  20. 76 FR 71445 - American Education Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-17

    ... November 17, 2011 Part II The President Proclamation 8753--American Education Week, 2011 #0; #0; #0... American Education Week, 2011 By the President of the United States of America A Proclamation Ensuring our... economic prosperity and our role as a thriving democracy. During American Education Week, we...

  1. 77 FR 42941 - Captive Nations Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... July 20, 2012 Part VI The President Proclamation 8841--Captive Nations Week, 2012 Memorandum of July 11... President ] Proclamation 8841 of July 16, 2012 Captive Nations Week, 2012 By the President of the United... Week amidst an escalating Cold War, he affirmed that ``the citizens of the United States are linked...

  2. Advanced tubal pregnancy at 30 weeks.

    PubMed

    Koçak, Idris; Dagdemir, Aynur; Yilmaz, Mustafa Sadi; Ustün, Cazip

    2005-08-01

    A case of advanced tubal pregnancy at 30 weeks is described. The placenta was implanted on the salpinx. Most tubal pregnancies become symptomatic within the first 12 weeks. A small number of tubal pregnancies have progressed beyond this. We present this unusual case of a 30-week tubal pregnancy situated in the proximal half of the tube that created a diagnostic dilemma.

  3. Oxidation of hydroquinone, 2,3-dimethylhydroquinone and 2,3,5-trimethylhydroquinone by human myeloperoxidase.

    PubMed

    Burner, U; Krapfenbauer, G; Furtmüller, P G; Regelsberger, G; Obinger, C

    2000-01-01

    Myeloperoxidase is very susceptible to reducing radicals because the reduction potential of the ferric/ferrous redox couple is much higher compared with other peroxidases. Semiquinone radicals are known to reduce heme proteins. Therefore, the kinetics and spectra of the reactions of p-hydroquinone, 2,3-dimethylhydroquinone and 2,3,5-trimethylhydroquinone with compounds I and II were investigated using both sequential-mixing stopped-flow techniques and conventional spectrophotometric measurements. At pH 7 and 15 degrees C the rate constants for compound I reacting with p-hydroquinone, 2,3-dimethylhydroquinone and 2,3,5-trimethylhydroquinone were determined to be 5.6+/-0.4 x 10(7) M(-1)s(-1), 1.3+/-0.1 x 10(6) M(-1)s(-1) and 3.1+/-0.3 x 10(6) M(-1)s(-1), respectively. The corresponding reaction rates for compound II reduction were calculated to be 4.5+/-0.3 x 10(6) M(-1)s(-1), 1.9+/-0.1 x 10(5) M(-1)s(-1) and 4.5+/-0.2 x 10(4) M(-1)s(-1), respectively. Semiquinone radicals, produced by compounds I and II in the classical peroxidation cycle, promote compound III (oxymyeloperoxidase) formation. We could monitor formation of ferrous myeloperoxidase as well as its direct transition to compound II by addition of molecular oxygen. Formation of ferrous myeloperoxidase is shown to depend strongly on the reduction potential of the corresponding redox couple benzoquinone/semiquinone. With 2,3-dimethylhydroquinone and 2,3,5-trimethylhydroquinone as substrate, myeloperoxidase is extremely quickly trapped as compound III. These MPO-typical features could have potential in designing specific drugs which inhibit the production of hypochlorous acid and consequently attenuate inflammatory tissue damage.

  4. Twice weekly prophylactic therapy in haemophilia A.

    PubMed Central

    Aronstam, A; Kirk, P J; McHardy, J; Culver-James, J W; McLellan, D S; Turk, P; Rainsford, S G; Slattery, M

    1977-01-01

    Factor VIII-containing materials were administered to four severely affected haemophiliacs twice weekly in doses calculated to raise the factor VIII level to either 15% or 30% of average normal. The pooled results from those patients with statistically similar baseline bleeding frequencies showed a significant reduction in bleeding frequency on both doses in the first 48 hours. The 30% dose produced a more significant reduction than the 15% dose in the first 24 hours, but there was no significant difference between the two doses in the second 24 hours. It appears that to reduce the bleeding frequency of severely affected haemophiliacs by 60% would require a two-and-a-half-fold increase in therapeutic materials. A 90% reduction would need nine times the amount of material currently in use. PMID:320230

  5. Ethics in 15-minutes per Week

    PubMed Central

    Peiffer, Ann M.; Hugenschmidt, Christina E.; Laurienti, Paul J.

    2013-01-01

    The demand for science trainees to have appropriate responsible conduct of research instruction continues to increase the attention shown by federal agencies and graduate school programs to the development of effective ethics curriculums. However, it is important to consider that the main learning environment for science graduate students and post-doctoral research fellows is within a laboratory setting. Here we discuss an internal laboratory program of weekly 15-minute ethics discussions implemented and used over the last three years in addition to the graduate school's program of scientific integrity training. During this time, the environment and culture within our laboratory has changed to place greater emphasis on the ethical implications of our own research and the research we evaluate. We still struggle with how to accurately assess this behavioral change; although, we present preliminary survey results on the evaluation and impact of this style of curriculum for ethics instruction in our laboratory. PMID:20213534

  6. Fire Pumps: Time to Change NFPA 25 Weekly Churn Testing

    ERIC Educational Resources Information Center

    Saidi, John F.; Davis, Richard J.

    2010-01-01

    APPA, through its Code Advocacy Task Force (CATF), is active with code organizations such as the National Fire Protection Association (NFPA). This article reviews some of the recent work on NFPA 25, Standard for the Inspection, Testing, and Maintenance of Water-Based Fire Protection Systems, by the CATF and some members of the NFPA 25 Technical…

  7. Engineering Klebsiella oxytoca for efficient 2, 3-butanediol production through insertional inactivation of acetaldehyde dehydrogenase gene.

    PubMed

    Ji, Xiao-Jun; Huang, He; Zhu, Jian-Guo; Ren, Lu-Jing; Nie, Zhi-Kui; Du, Jun; Li, Shuang

    2010-02-01

    Ethanol was a major byproduct of 2,3-butanediol (2,3-BD) fermentation by Klebsiella oxytoca ME-UD-3. In order to achieve a high efficiency of 2,3-BD production, K. oxytoca mutants deficient in ethanol formation were successfully constructed by replace the aldA gene coding for aldehyde dehydrogenase with a tetracycline resistance cassette. The results suggested that inactivation of aldA led to a significantly improved 2,3-BD production. The carbon flux to 2,3-BD was enhanced by eliminating the byproducing ethanol and at the same time reducing the accumulation of another byproduct acetoin. At last, by fed-batch culturing of the mutant, the final 2,3-BD titer up to 130 g/l with the productivity of 1.63 g/l.h and the 2,3-BD yield relative to glucose of 0.48 g/g was obtained.

  8. Neuromuscular Adaptations After 2 and 4 Weeks of 80% Versus 30% 1 Repetition Maximum Resistance Training to Failure.

    PubMed

    Jenkins, Nathaniel D M; Housh, Terry J; Buckner, Samuel L; Bergstrom, Haley C; Cochrane, Kristen C; Hill, Ethan C; Smith, Cory M; Schmidt, Richard J; Johnson, Glen O; Cramer, Joel T

    2016-08-01

    Jenkins, NDM, Housh, TJ, Buckner, SL, Bergstrom, HC, Cochrane, KC, Hill, EC, Smith, CM, Schmidt, RJ, Johnson, GO, and Cramer, JT. Neuromuscular adaptations after 2 and 4 weeks of 80% versus 30% 1 repetition maximum resistance training to failure. J Strength Cond Res 30(8): 2174-2185, 2016-The purpose of this study was to investigate the hypertrophic, strength, and neuromuscular adaptations to 2 and 4 weeks of resistance training at 80 vs. 30% 1 repetition maximum (1RM) in untrained men. Fifteen untrained men (mean ± SD; age = 21.7 ± 2.4 years; weight = 84.7 ± 23.5 kg) were randomly assigned to either a high-load (n = 7) or low-load (n = 8) resistance training group and completed forearm flexion resistance training to failure 3 times per week for 4 weeks. Forearm flexor muscle thickness (MT) and echo intensity, maximal voluntary isometric (MVIC) and 1RM strength, and the electromyographic, mechanomyographic (MMG), and percent voluntary activation (%VA) responses at 10-100% of MVIC were determined at baseline, 2, and 4 weeks of training. The MT increased from baseline (2.9 ± 0.1 cm) to week 2 (3.0 ± 0.1 cm) and to week 4 (3.1 ± 0.1 cm) for the 80 and 30% 1RM groups. MVIC increased from week 2 (121.5 ± 19.1 Nm) to week 4 (138.6 ± 22.1 Nm) and 1RM increased from baseline (16.7 ± 1.6 kg) to weeks 2 and 4 (19.2 ± 1.9 and 20.5 ± 1.8 kg) in the 80% 1RM group only. The MMG amplitude at 80 and 90% MVIC decreased from baseline to week 4, and %VA increased at 20 and 30% MVIC for both groups. Resistance training to failure at 80 vs. 30% 1RM elicited similar muscle hypertrophy, but only 80% 1RM increased muscle strength. However, these disparate strength adaptations were difficult to explain with neuromuscular adaptations because they were subtle and similar for the 80 and 30% 1RM groups.

  9. 2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions.

    PubMed

    Shi, Junxing; Ray, Adrian S; Mathew, Judy S; Anderson, Karen S; Chu, Chung K; Schinazi, Raymond F

    2004-05-03

    2('),3(')-Didehydro-2('),3(')-dideoxynucleosides are clinically relevant antiviral agents. These nucleosides could be degraded under acidic conditions. Acidic stability studies showed the D4N had the following increasing stability order: D4G

  10. Randomized controlled trial for early intervention for autism: a pilot study of the Autism 1-2-3 Project.

    PubMed

    Wong, Virginia C N; Kwan, Queenie K

    2010-06-01

    We piloted a 2-week "Autism-1-2-3" early intervention for children with autism and their parents immediately after diagnosis that targeted at (1) eye contact, (2) gesture and (3) vocalization/words. Seventeen children were randomized into the Intervention (n = 9) and Control (n = 8) groups. Outcome measures included the Autism Diagnostic Observation Schedule, Ritvo-Freeman Real Life Rating Scale, Symbolic Play Test, and Parenting Stress Index. Children with autism improved in language/communication, reciprocal social interaction, and symbolic play. Parents perceived significant improvement in their children's language, social interaction, and their own stress level. This intervention can serve as short-term training on communication and social interaction for children with autism, and reduce the stress of their parents during the long waiting time for public health services.

  11. [A new regimen for TS-1 therapy designed to minimize adverse reactions by introducing a one-week interval after each two-week dosing session].

    PubMed

    Kimura, Yutaka; Kikkawa, Nobuteru; Iijima, Shohei; Kato, Takeshi; Naoi, Yasuto; Hayashi, Taro; Tanigawa, Takahiko; Yamamoto, Hitoshi; Kurokawa, Eiji

    2002-08-01

    It has been reported that the response rate to TS-1 of advanced recurrent gastric cancer was the highest rate (46.5%) of effectiveness among anti-cancer agents, but the incidence of adverse reactions to this drug has been found to be as high as 83.2%, with grade 3 or severer reactions occurring in 20.3% of patients. Taking into consideration the post-marketing survey finding that adverse reactions to the drug first appear 2-3 weeks after the start of oral TS-1 therapy, we attempted a new dosing regimen for this drug, wherein each session of therapy lasted for 2 weeks, with a one-week interval between two consecutive sessions (herein-after called "the 2-week regimen"). This regimen was employed based on the expectation that the adverse reactions to the drug would be minimized and that the consecutive dosing period could be prolonged, while keeping the anti-cancer potency at a level similar to that expected with the 4-week dosing regimen with a 2-week interval between sessions (the 4-week regimen). The subjects were 38 patients with advanced or recurrent stomach cancer who were treated with TS-1 at our center between September 1999 and November 2001. Twenty-four patients treated using the 4-week method until January 2001 were taken as a historical control, and compared with 14 patients treated using the 2-week method from February 2001 and afterwards. The incidence of adverse reactions was 71% in the 2-week regimen group against 92% in the 4-week regimen group. The incidence of grade 3 or severe adverse reactions was 8% in the 2-week group and 21% in the 4-week group. Thus, the incidence of adverse reactions was lower in the 2-week group. The percentage of patients who complied with the dosing instructions completely during a 6-month period, as evaluated by the Kaplan-Meier method, was 86% in the 2-week group and 58% in the 4-week group. The response rate, as calculated in patients whose lesions could be evaluated, was 25% in the 2-week group and 19% in the 4-week

  12. 75 FR 70999 - National Entrepreneurship Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-19

    ... Proclamation 8600--National Entrepreneurship Week, 2010 Proclamation 8601--America Recycles Day, 2010 #0; #0... 15, 2010 National Entrepreneurship Week, 2010 By the President of the United States of America A... and work hard enough, the American dream is within your reach. During National Entrepreneurship...

  13. National Poison Prevention Week Promotional Materials.

    ERIC Educational Resources Information Center

    Poison Prevention Week Council, Washington, DC.

    This collection of materials for parents, early childhood workers, the elderly, and anyone in situations requiring safeguards against poisoning, spans the years 1993 and 1994 and is intended to promote National Poison Prevention Week. The materials included are: (1) the 31-page, illustrated report on National Poison Prevention Week for 1993,…

  14. National Women's History Week Community Organizing Guide.

    ERIC Educational Resources Information Center

    Women's Support Network, Inc., Santa Rosa, CA.

    Materials for planning, organizing, and scheduling community activities for National Women's History Week (NWHW) are provided. The purpose of the week was to help male and female students become aware of the wealth of women's history that has been left out of the standard U.S. history texts used in most schools. Section 1 summarizes a sample of…

  15. 75 FR 62307 - Fire Prevention Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-08

    ... 8577 of October 1, 2010 Fire Prevention Week, 2010 By the President of the United States of America A Proclamation During Fire Prevention Week, we reaffirm the importance of fire safety and awareness, and we pay... our loved ones from the hazards of fire. Smoke alarms are vital detection devices, and...

  16. 78 FR 62305 - Fire Prevention Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-16

    ... Documents#0;#0; #0; #0;Title 3-- #0;The President ] Proclamation 9034 of October 4, 2013 Fire Prevention Week, 2013 By the President of the United States of America A Proclamation Fires take more American... communities, and they cost our Nation billions of dollars each year. During Fire Prevention Week, we...

  17. Crystalline 1H-1,2,3-triazol-5-ylidenes

    SciTech Connect

    Bertrand, Guy; Gulsado-Barrios, Gregorio; Bouffard, Jean; Donnadieu, Bruno

    2016-08-02

    The present invention provides novel and stable crystalline 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes. The present invention also provides methods of making 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes. The present invention also provides methods of using 1H-1,2,3 triazolium carbenes and metal complexes of 1H-1,2,3 triazolium carbenes in catalytic reactions.

  18. A 6-week Sprint Interval Training Program Changes Anaerobic Power, Quadriceps Moment, and Subcutaneous Tissue Thickness.

    PubMed

    Han, Seunguk; Lee, Hyungkyu; Kim, Hyungkee; Kim, Dasol; Choi, Changkyu; Park, Jihong

    2017-02-01

    We examined the effects of a 6-week 40-m one-way sprint interval training program (based on sprint time). 13 untrained healthy male collegiate students performed six 40-m sprints with a 60-s resting interval between sprints during the first week, and one sprint was added each week until the sixth week. If the 40-m sprint time exceeded 110% of the fastest baseline 40-m sprint time, the run was repeated. Repeated-sprint cycling test (every 3 weeks), quadriceps moment (every 2 weeks), and abdominal and thigh subcutaneous tissue thickness (every 2 weeks) were measured. Compared to baseline, mean power output improved at week 3 (16.27 vs. 17.73 Watt/kg, p=0.004). Regardless of side, quadriceps moment began to increase at week 4 (2.88 vs. 3.15 N·m/kg, p=0.03). Subcutaneous tissue thickness was reduced at week 2 (abdominal: 11.19 vs. 9.65 mm, p=0.01; thigh: 9.17 vs. 8.12 mm, p=0.009). Our results suggest that (1) sprint training with an intensity of 110% of the fastest baseline 40-m sprint time with the addition of one sprint per week produces similar effects to other training programs, and (2) untrained individuals need 4 weeks of training for strength development in the quadriceps and 2 weeks for reduction in fat tissue thickness.

  19. High Production of 2,3-Butanediol (2,3-BD) by Raoultella ornithinolytica B6 via Optimizing Fermentation Conditions and Overexpressing 2,3-BD Synthesis Genes

    PubMed Central

    Kim, Taeyeon; Cho, Sukhyeong; Lee, Sun-Mi; Woo, Han Min; Lee, Jinwon; Seo, Jin-Ho

    2016-01-01

    Biological production of 2,3-butandiol (2,3-BD) has received great attention as an alternative to the petroleum-based 2,3-BD production. In this study, a high production of 2,3-BD in fed-batch fermentation was investigated with a newly isolated bacterium designated as Raoultella ornithinolytica B6. The isolate produced 2,3-BD as the main product using hexoses (glucose, galactose, and fructose), pentose (xylose) and disaccharide (sucrose). The effects of temperature, pH-control schemes, and agitation speeds on 2,3-BD production were explored to optimize the fermentation conditions. Notably, cell growth and 2,3-BD production by R. ornithinolytica B6 were higher at 25°C than at 30°C. When three pH control schemes (no pH control, pH control at 7, and pH control at 5.5 after the pH was decreased to 5.5 during fermentation) were tested, the best 2,3-BD titer and productivity along with reduced by-product formation were achieved with pH control at 5.5. Among different agitation speeds (300, 400, and 500 rpm), the optimum agitation speed was 400 rpm with 2,3-BD titer of 68.27 g/L, but acetic acid was accumulated up to 23.32 g/L. Further enhancement of the 2,3-BD titer (112.19 g/L), yield (0.38 g/g), and productivity (1.35 g/L/h) as well as a significant reduction of acetic acid accumulation (9.71 g/L) was achieved by the overexpression of homologous budABC genes, the 2,3-BD-synthesis genes involved in the conversion of pyruvate to 2,3-BD. This is the first report presenting a high 2,3-BD production by R.ornithinolytica which has attracted little attention with respect to 2,3-BD production, extending the microbial spectrum of 2,3-BD producers. PMID:27760200

  20. Vehicle Technologies Fact of the Week 2015

    SciTech Connect

    Davis, Stacy C.; Diegel, Susan W.; Moore, Sheila A.; Boundy, Robert G.

    2016-05-01

    Each week the U.S. Department of Energy s Vehicle Technology Office (VTO) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/ . These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current week s Fact is available on the VTO homepage, but older Facts (back to 2009) are archived and still available at: http://energy.gov/eere/vehicles/current-and-past-years-facts-week. Each Fact of the Week website page includes a link to an Excel file. That file contains the data from the Supporting Information section of the page so that researchers can easily use data from the Fact of the Week in their work. Beginning in August of 2015, a subscription list is available on the DOE website so that those interested can sign up for an email to be sent each Monday which includes the text and graphic from the current week s Fact. This report is a compilation of the Facts that were posted during calendar year 2015. The Facts were created, written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

  1. The effect of 8-week plyometric training on leg power, jump and sprint performance in female soccer players.

    PubMed

    Ozbar, Nurper; Ates, Seda; Agopyan, Ani

    2014-10-01

    The aim of this study was to determine the effect of 8-week plyometric training (PT) on the leg power and jump and sprint performance in female soccer players. Eighteen female soccer players from Women Second League (age = 18.2 ± 2.3 years, height = 161.3 ± 5.4 cm, body mass = 56.6 ± 7.2 kg) were randomly assigned to control (n = 9) and plyometric (n = 9) groups. Both groups continued together with regular technical and tactical soccer training for 4 days a week. Additionally, the plyometric group underwent PT for 8 weeks, 1 day per week, 60-minute session duration. During the 8-week period, the control group was hindered from any additional conditioning training. All players' jumps (triple hop, countermovement jump, and standing broad jump), running speed (20 m), and peak power were evaluated before and after 8 weeks. No significant difference was found between the groups at pretest variables (p > 0.05). Significant improvements were found in the posttest of both the groups (p ≤ 0.05), except for 20-m sprint test in the control group (p > 0.05). Triple hop distance, countermovement jump, standing broad jump, peak power, and 20-m sprint test values were all significantly improved in the plyometric group, compared with the control group (p ≤ 0.05). We concluded that short duration PT is an improved important component of athletic performance in female soccer players. The results indicate that safe, effective, and alternative PT can be useful to strength and conditioning coaches, especially during competition season where less time is available for training.

  2. Weekly cycle of aerosol-meteorology interaction over China

    SciTech Connect

    Gong, Daoyi; Ho, Chang-Hoi; Chen, Deliang; Qian, Yun; Choi, Yong-Sang; Kim, Jinwon

    2007-11-21

    Weekly cycles of the concentration of anthropogenic aerosols have been observed in many regions around the world. The phase and the magnitude of these cycles, however, vary greatly depending on region and season. In the present study the authors investigated important features of the weekly cycles of aerosol concentration and the co-variations in meteorological conditions in major urban regions over east China, one of the most polluted areas in the world, in summertime during the period 2001-2005/2006. The PM10 (aerosol particulate matters of diameter < 10μm) concentrations at 29 monitoring stations show significant weekly cycles with the largest values around midweek and smallest values in weekend. Accompanying the PM10 cycle, the meteorological variables also show notable and consistent weekly cycles. The wind speed in lower troposphere is relatively small in the early part of the week, and increases after about Wednesday. At the same time, the air temperature anomalies in low levels are positive, and then become negative in the later part of the week. The authors hypothesized that the changes in the atmospheric circulation may be triggered by the accumulation of PM10 through diabatic heating of lower troposphere. During the early part of a week the anthropogenic aerosols are gradually accumulated in the lower troposphere. Around midweek, the accumulated aerosols could induce radiative heating, likely destabilizing the mid- to lower troposphere and generating anomalously vertical air motion, and thus resulting in stronger winds. The resulting circulation could promote ventilation to reduce aerosol concentrations in the boundary layer during the later part of the week. Corresponding to this cycle in anthropogenic aerosols the frequency of precipitation, particularly the light rain events, tends to be suppressed around mid-weekdays through indirect aerosol effects. This is consistent with the observed anthropogenic weather cycles, i.e., more (less) solar radiation

  3. 28 CFR 2.3 - Same: Narcotic Addict Rehabilitation Act.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Same: Narcotic Addict Rehabilitation Act. 2.3 Section 2.3 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... § 2.3 Same: Narcotic Addict Rehabilitation Act. A Federal prisoner committed under the Narcotic...

  4. 28 CFR 2.3 - Same: Narcotic Addict Rehabilitation Act.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Same: Narcotic Addict Rehabilitation Act. 2.3 Section 2.3 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... § 2.3 Same: Narcotic Addict Rehabilitation Act. A Federal prisoner committed under the Narcotic...

  5. 28 CFR 2.3 - Same: Narcotic Addict Rehabilitation Act.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Same: Narcotic Addict Rehabilitation Act. 2.3 Section 2.3 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... § 2.3 Same: Narcotic Addict Rehabilitation Act. A Federal prisoner committed under the Narcotic...

  6. 28 CFR 2.3 - Same: Narcotic Addict Rehabilitation Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Same: Narcotic Addict Rehabilitation Act. 2.3 Section 2.3 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... § 2.3 Same: Narcotic Addict Rehabilitation Act. A Federal prisoner committed under the Narcotic...

  7. 28 CFR 2.3 - Same: Narcotic Addict Rehabilitation Act.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Same: Narcotic Addict Rehabilitation Act. 2.3 Section 2.3 Judicial Administration DEPARTMENT OF JUSTICE PAROLE, RELEASE, SUPERVISION AND... § 2.3 Same: Narcotic Addict Rehabilitation Act. A Federal prisoner committed under the Narcotic...

  8. 10 CFR 2.3 - Resolution of conflict.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Resolution of conflict. 2.3 Section 2.3 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS § 2.3 Resolution of conflict. (a) In any conflict between a general rule in subpart C of this part and a...

  9. 10 CFR 2.3 - Resolution of conflict.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Resolution of conflict. 2.3 Section 2.3 Energy NUCLEAR REGULATORY COMMISSION AGENCY RULES OF PRACTICE AND PROCEDURE § 2.3 Resolution of conflict. (a) In any conflict between a general rule in subpart C of this part and a special rule in another subpart or...

  10. 10 CFR 2.3 - Resolution of conflict.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Resolution of conflict. 2.3 Section 2.3 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS § 2.3 Resolution of conflict. (a) In any conflict between a general rule in subpart C of this part and a...

  11. 17 CFR 2.3 - Prohibitions against misuse of seal.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... seal. 2.3 Section 2.3 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION OFFICIAL SEAL § 2.3 Prohibitions against misuse of seal. (a) Fraudulently or wrongfully affixing or impressing the Seal to or upon any certificate, instrument, document or paper or with knowledge of its...

  12. 17 CFR 2.3 - Prohibitions against misuse of seal.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... seal. 2.3 Section 2.3 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION OFFICIAL SEAL § 2.3 Prohibitions against misuse of seal. (a) Fraudulently or wrongfully affixing or impressing the Seal to or upon any certificate, instrument, document or paper or with knowledge of its...

  13. 17 CFR 2.3 - Prohibitions against misuse of seal.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... seal. 2.3 Section 2.3 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION OFFICIAL SEAL § 2.3 Prohibitions against misuse of seal. (a) Fraudulently or wrongfully affixing or impressing the Seal to or upon any certificate, instrument, document or paper or with knowledge of its...

  14. 17 CFR 2.3 - Prohibitions against misuse of seal.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... seal. 2.3 Section 2.3 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION OFFICIAL SEAL § 2.3 Prohibitions against misuse of seal. (a) Fraudulently or wrongfully affixing or impressing the Seal to or upon any certificate, instrument, document or paper or with knowledge of its...

  15. 17 CFR 2.3 - Prohibitions against misuse of seal.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... seal. 2.3 Section 2.3 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION OFFICIAL SEAL § 2.3 Prohibitions against misuse of seal. (a) Fraudulently or wrongfully affixing or impressing the Seal to or upon any certificate, instrument, document or paper or with knowledge of its...

  16. 10 CFR 2.3 - Resolution of conflict.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Resolution of conflict. 2.3 Section 2.3 Energy NUCLEAR REGULATORY COMMISSION AGENCY RULES OF PRACTICE AND PROCEDURE § 2.3 Resolution of conflict. (a) In any conflict between a general rule in subpart C of this part and a special rule in another subpart or...

  17. 10 CFR 2.3 - Resolution of conflict.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Resolution of conflict. 2.3 Section 2.3 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS § 2.3 Resolution of conflict. (a) In any conflict between a general rule in subpart C of this part and a...

  18. 10 CFR 960.5-2-3 - Meteorology.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Meteorology. 960.5-2-3 Section 960.5-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines Preclosure Radiological Safety § 960.5-2-3 Meteorology. (a)...

  19. 10 CFR 960.5-2-3 - Meteorology.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Meteorology. 960.5-2-3 Section 960.5-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines Preclosure Radiological Safety § 960.5-2-3 Meteorology. (a)...

  20. 10 CFR 960.5-2-3 - Meteorology.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Meteorology. 960.5-2-3 Section 960.5-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines Preclosure Radiological Safety § 960.5-2-3 Meteorology. (a)...

  1. 10 CFR 960.5-2-3 - Meteorology.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Meteorology. 960.5-2-3 Section 960.5-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines Preclosure Radiological Safety § 960.5-2-3 Meteorology. (a)...

  2. 10 CFR 960.5-2-3 - Meteorology.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Meteorology. 960.5-2-3 Section 960.5-2-3 Energy DEPARTMENT OF ENERGY GENERAL GUIDELINES FOR THE PRELIMINARY SCREENING OF POTENTIAL SITES FOR A NUCLEAR WASTE REPOSITORY Preclosure Guidelines Preclosure Radiological Safety § 960.5-2-3 Meteorology. (a)...

  3. Elementary Physical Education Weekly Lesson Plan. Kindergarten.

    ERIC Educational Resources Information Center

    Anchorage Borough School District, AK.

    This curriculum guide is for the teaching of physical education to kindergarten students. Teaching procedures, warm-up activities, safety procedures, modifications, and athletic equipment needed are described for each of the specific activities in the weekly lesson plans. (CJ)

  4. Foreign Language Week--Celebrate It!

    ERIC Educational Resources Information Center

    Allison, Mary L.

    1982-01-01

    Suggestions are given for activities to celebrate Foreign Language Week, including public awareness exhibits, teacher involvement, food-related activities, sports, festivals and fairs, round tables and discussions, library involvement, planning and organizing techniques, and publicity efforts. (MSE)

  5. A weekly cycle in atmospheric carbon dioxide

    NASA Astrophysics Data System (ADS)

    Cerveny, Randall S.; Coakley, Kevin J.

    2002-01-01

    We present a new statistic called the ``Mean Symmetrized Residual'' (MSR) for detection and quantification of a weekly cycle in measured daily atmospheric carbon dioxide (CO2). At the Mauna Loa Observatory in Hawaii, we conclude that CO2 concentrations, on average, are significantly lower (0.022 parts per million by volume, ppmv) on weekends (Saturday-Sunday) than during the rest of the week. Over the past twenty-five years, the variation of the mean values of MSR (as a function of day of the week) has been relatively stable. We speculate that the observed weekday/weekend variation in CO2 at Mauna Loa is the result of anthropogenic emissions on Hawaii and nearby sources. We do not detect a weekly cycle in daily CO2 concentration measured at South Pole, Antarctica. This methodology has applicability to a variety of datasets.

  6. This Week @ NASA - 11/5/10

    NASA Video Gallery

    The Postponement of Mission STS-133 tops the billboard on This Week @ NASA. Also, EPOXI meets a Comet, NASA and LEGO build a future together, Administrator Bolden heralds ten years of ISS, KSC Twee...

  7. The Effects of a Four-Week Summer Bridge Program.

    ERIC Educational Resources Information Center

    Ami, Carlon G.

    This study reports the results of the pre and post mathematics test administered to student participants of the 2001 Summer Bridge Program, sponsored by the Minority Engineering, Mathematics and Science Department (MEMS) at the University of New Mexico (UNM). There was a four-week time span between the administration of the standardized test,…

  8. Special Relativity in Week One: 3) Introducing the Lorentz Contraction

    ERIC Educational Resources Information Center

    Huggins, Elisha

    2011-01-01

    This is the third of four articles on teaching special relativity in the first week of an introductory physics course. With Einstein's second postulate that the speed of light is the same to all observers, we could use the light pulse clock to introduce time dilation. But we had difficulty introducing the Lorentz contraction until we saw the movie…

  9. 3 CFR 8432 - Proclamation 8432 of October 2, 2009. Fire Prevention Week, 2009

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Prevention Week, 2009 8432 Proclamation 8432 Presidential Documents Proclamations Proclamation 8432 of October 2, 2009 Proc. 8432 Fire Prevention Week, 2009By the President of the United States of America A.... Fire Prevention Week is a time to learn about important fire safety issues and empower our...

  10. 75 FR 20778 - Security Zone; Portland Rose Festival Fleet Week, Willamette River, Portland, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-21

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA87 Security Zone; Portland Rose Festival Fleet Week... Hawthorne and Steel Bridges in Portland, Oregon during the Portland Rose Festival Fleet Week from June 2... Rose Festival Fleet Week, and there is insufficient time to publish a notice of proposed...

  11. Request for a Copy of the Decision in "Weeks v. The United States"

    ERIC Educational Resources Information Center

    Jones, Megan

    2011-01-01

    On December 21, 1911, Fremont Weeks, an employee of the Adams Express Company, was arrested while on the job at Union Station in Kansas City, Missouri. Police suspected that Weeks was selling and "transmitting chances" in a lottery, which at the time was considered gambling, an illegal action in Missouri. While Weeks was being held at…

  12. [Incremental approach to hemodialysis: twice a week, or once weekly hemodialysis combined with low-protein low-phosphorus diet?].

    PubMed

    Bolasco, Piergiorgio; Caria, Stefania; Egidi, Maria Francesca; Cupisti, Adamasco

    2015-01-01

    The start of dialysis treatment is a critical step in the care management of chronic renal failure patients. When hemodialysis is performed three times a week, rapid loss of kidney function and of urine volume output generally occur and this represents an unfavorable prognostic factor. Instead, reducing frequency of hemodialysis sessions, as well as peritoneal dialysis, can contribute to a lesser decrease of residual renal function. Unfortunately, the existing protocols for an incremental hemodialysis approach are not particularly common and they are generally limited to a twice a week hemodialysis schedule. In addition to clinical and economic reasons, an incremental approach to ESRD also contributes to better social and psychological adaptation by the patients to the dramatic change in living conditions linked to the maintenance dialysis treatment. In patients who have attitude for low-protein nutritional therapy, a once weekly dialysis schedule combined with low-protein, low-phosphorus, normal to high energy diet in the remaining six days of the week can be implemented in selected patients. In our experience, this kind of program produced important clinical results and reduction in costs and hospitalization. When compared with a three times a week dialysis schedule, a greater protection of residual renal function and of urine volume output, lower increase in 2 microglobulin, better control of phosphorus and less consumption of phosphate binders and erythropoietin were observed. Careful clinical monitoring and nutrition is essential for the safety and optimization of infrequent hemodialysis. Long-term follow-up analysis shows favorable effects on the overall survival. Furthermore, twice a week hemodialysis is not the only option for an incremental approach of dialysis commencing. In patients who have a good attitude for low-protein nutritional therapy, its arrangement with a program of once weekly dialysis represents a real and effective alternative.

  13. Design of a Multi-Week Sound and Motion Recording and Telemetry (SMRT) Tag for Behavioral Studies on Whales

    DTIC Science & Technology

    2015-09-30

    1 DISTRIBUTION STATEMENT A. Approved for public release; distribution is unlimited. Design of a Multi- Week Sound and Motion Recording and...responses to longer sound exposures such as Navy sonar exercises. To sample before, during, and after these exercises, a tag duration of 2-3 weeks may be...expensive or infeasible to recover tags that are attached to whales for several weeks necessitating that essential information be transmitted via low data

  14. Vehicle Technologies' Fact of the Week 2012

    SciTech Connect

    Davis, Stacy Cagle; Diegel, Susan W; Moore, Sheila A; Boundy, Robert Gary

    2013-02-01

    Each week the U.S. Department of Energy s Vehicle Technology Office (VTO) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/ . These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current week s Fact is available on the VTO homepage, but older Facts are archived and still available at: http://www1.eere.energy.gov/vehiclesandfuels/facts/. This report is a compilation of the Facts that were posted during calendar year 2012. The Facts were written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

  15. STAR WEEK: A Successful Campaign in Japan

    NASA Astrophysics Data System (ADS)

    Watanabe, Junichi

    2011-06-01

    A campaign of the Star Week, set as August 1 - 7, has been started in 1995 throughout various life-learning facilities. Astronomical facilities including planetariums, science museums, and public observatories has been participating in this campaign, together with amateur astronomers clubs or private observatories. More than 300 astronomical events such as star watching parties were coordinated for general public every year. The Star Week has been grown up to one of the most successful campaigns not only for for astronomy but also for basic sciences in Japan over this 15 years. In this paper, a brief history and the present status of the Star Week are introduced together with the with some statistics.

  16. Vehicle Technologies Fact of the Week 2013

    SciTech Connect

    Davis, Stacy Cagle; Williams, Susan E; Moore, Sheila A; Boundy, Robert Gary

    2014-03-01

    Each week the U.S. Department of Energy s Vehicle Technology Office (VTO) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/ . These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current week s Fact is available on the VTO homepage, but older Facts are archived and still available at: http://www1.eere.energy.gov/vehiclesandfuels/facts/. This report is a compilation of the Facts that were posted during calendar year 2013. The Facts were written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

  17. Rupture rudimentary horn pregnancy at 31 week

    PubMed Central

    Al Qarni, Abdullah A.; Al-Braikan, Nawal; Al-Hanbali, Moh’d M.; Alharmaly, Abdullah H.

    2017-01-01

    Rudimentary horn could be a rare congenital uterine anomalies result from incomplete fusion of the 2 Müllerian ducts throughout embryo-genesis. Pregnancy in an exceedingly rudimentary horn is rare and typically terminates in rupture throughout the late of first or second trimester of pregnancy. We tend to present a rare case of a gravida within the trimester (31 weeks) presented with complain of abdominal pain, nausea, and vomit for 3 days. On presentation, the patient was pale and irritable. Ultrasound scan showed fetus at (30 weeks) with cardiac activity. Cardiotocography reactive. Incision showed horned uterus with pregnancy in rudimentary left horn that was ruptured. Alive fetus was delivered. The rudimentary left horn was excised. The patient was advised to not get pregnant for 3 years. Within one year, the patient came to hospital in active labor at (37 weeks). This case emphasizes the importance of fine antepartum care to avoid morbidity and mortality. PMID:28133695

  18. Rupture rudimentary horn pregnancy at 31 week.

    PubMed

    Al Qarni, Abdullah A; Al-Braikan, Nawal; Al-Hanbali, Moh'd M; Alharmaly, Abdullah H

    2017-02-01

    Rudimentary horn could be a rare congenital uterine anomalies result from incomplete fusion of the two Müllerian ducts throughout embryo-genesis. Pregnancy in an exceedingly rudimentary horn is rare and typically terminates in rupture throughout the late of first or second trimester of pregnancy. We tend to present a rare case of a gravida within the trimester (31 weeks) presented with complain of abdominal pain, nausea, and vomit for 3 days. On presentation, the patient was pale and irritable. Ultrasound scan showed fetus at (30 weeks) with cardiac activity. Cardiotocography reactive. Incision showed horned uterus with pregnancy in rudimentary left horn that was ruptured. Alive fetus was delivered. The rudimentary left horn was excised. The patient was advised to not get pregnant for 3 years. Within one year, the patient came to hospital in active labor at (37 weeks). This case emphasizes the importance of fine antepartum care to avoid morbidity and mortality.

  19. Radiation-induced degradation of aqueous 2,3-dihydroxynaphthalene

    NASA Astrophysics Data System (ADS)

    Wasiewicz, Malgorzata; Chmielewski, Andrzej G.; Getoff, Nikola

    2006-02-01

    The degradation of aqueous 2,3-dihydroxynaphthaline (2,3-DHN) under the influence of γ-ray was investigated under various experimental conditions. Using 2.5×10 -5 mol L -1 2,3-DHN in aerated media (pH=6-6.8) an initial degradation yield, Gi-(2,3-DHN)=0.32 was obtained, whereas in solutions saturated with N 2O the yield come to Gi-(2,3-DHN)=0.50. In airfree media the substrate decomposition was negligible. Possible reaction mechanisms are presented. Further, the rate constant, k(OH+2,3-DHN)=2.14×10 10 L mol -1 s -1 was determined by competition reactions with PNDA.

  20. Condensed phase preparation of 2,3-pentanedione

    DOEpatents

    Miller, Dennis J.; Perry, Scott M.; Fanson, Paul T.; Jackson, James E.

    1998-01-01

    A condensed phase process for the preparation of purified 2,3-pentanedione from lactic acid and an alkali metal lactate is described. The process uses elevated temperatures between about 200.degree. to 360.degree. C. for heating a reaction mixture of lactic acid and an alkali metal lactate to produce the 2,3-pentanedione in a reaction vessel. The 2,3-pentanedione produced is vaporized from the reaction vessel and condensed with water.

  1. Condensed phase preparation of 2,3-pentanedione

    DOEpatents

    Miller, D.J.; Perry, S.M.; Fanson, P.T.; Jackson, J.E.

    1998-11-03

    A condensed phase process for the preparation of purified 2,3-pentanedione from lactic acid and an alkali metal lactate is described. The process uses elevated temperatures between about 200 to 360 C for heating a reaction mixture of lactic acid and an alkali metal lactate to produce the 2,3-pentanedione in a reaction vessel. The 2,3-pentanedione produced is vaporized from the reaction vessel and condensed with water. 5 figs.

  2. Randomized Controlled Trial for Early Intervention for Autism: A Pilot Study of the Autism 1-2-3 Project

    ERIC Educational Resources Information Center

    Wong, Virginia C. N.; Kwan, Queenie K.

    2010-01-01

    We piloted a 2-week "Autism-1-2-3" early intervention for children with autism and their parents immediately after diagnosis that targeted at (1) eye contact, (2) gesture and (3) vocalization/words. Seventeen children were randomized into the Intervention (n = 9) and Control (n = 8) groups. Outcome measures included the Autism Diagnostic…

  3. Spectroscopic identification of dichlorobenzyl radicals: Jet-cooled 2,3-dichlorobenzyl radical

    NASA Astrophysics Data System (ADS)

    Chae, Sang Youl; Yoon, Young Wook; Lee, Sang Kuk

    2015-07-01

    The vibronically excited but jet-cooled 2,3-dichlorobenzyl radical was generated from the corona discharge of precursor 2,3-dichlorotoluene seeded in a large amount of carrier gas He using a pinhole-type glass nozzle. From an analysis of the visible vibronic emission spectrum observed, we obtained the electronic energy of the D1 → D0 transition and vibrational mode frequencies in the D0 state of the 2,3-dichlorobenzyl radical by comparing the observation with the results of ab initio calculations. In addition, we discussed substituent effect of Cls on electronic transition energy in terms of substituent orientation for the first time.

  4. A 4-Day Work Week That Works.

    ERIC Educational Resources Information Center

    Walker, Kenneth; Timmerman, Linda

    1980-01-01

    Describes Navarro College's (Corsicana, TX) program to reduce kilowatt hour consumption through alternative energy sources and energy costs through transition to a four-day/40-hour work week. Presents results of studies of employee performance levels, community response, and the cost effectiveness of the program. Lists benefits for the student,…

  5. What to Do in Week One?

    ERIC Educational Resources Information Center

    Wormeli, Rick

    2016-01-01

    Although teachers can build positive relationships with students throughout the school year, the first weeks are crucial, writes Wormeli. They set the tone and conditions for the year ahead, creating a more effective teaching and learning enterprise for everyone. Wormeli tells how, as a middle school teacher, he set a goal of learning the names of…

  6. [Seventh National Population Week in Rwanda, 1993].

    PubMed

    Munyanziza, B

    1993-08-01

    The 1993 National Population Week opened in the commune of Rutare on August 2 and ended in Gikongoro in the commune of Rwamiko on August 6. Its goal was to sensitize all levels of the population to Rwanda's demographic problems through an IEC (information, education, communication) program while respecting the individual liberty, and the moral and religious beliefs of couples. On the first day of the population education campaign, the mayors of each commune along with its elite presided over a meeting to discuss implementation of the campaign, the sociodemographic situation at the commune level (especially at the household level), and the importance of family planning in family health. During August 2-5 at the commune level, the communal elite and the abakangurambagas presided over sensitization meetings, conference-debates, educational discussions, home visits, theatrical sessions, songs and dances, orientation to health centers, and recruitment of family planning acceptors. On the last day, development technicians working in the commune, teachers, students, religious leaders, abakangurambagas, political party leaders, and mass media journalists, all of whom took part in the week's activities, met at the communal office to evaluate the week's activities and to amass resolutions and recommendations. The mayor closed the 1993 edition of the National Population Week after the evaluation.

  7. National Geography Awareness Week 1987: An Assessment.

    ERIC Educational Resources Information Center

    Holcomb, Briavel; Tiefenbacher, John

    1989-01-01

    Assesses the first National Geography Awareness Week that was held from November 15-21, 1987. Points out that there was much media coverage about how geographically ignorant the U.S. population was. Contends that this public relations event had little impact on improving the image of geography as a serious discipline. (GG)

  8. First Few Weeks on Campus. Prevention Update

    ERIC Educational Resources Information Center

    Higher Education Center for Alcohol, Drug Abuse, and Violence Prevention, 2010

    2010-01-01

    Every fall, college and university campuses and communities brace for the onslaught of new and returning students. For first-year students, anecdotal evidence suggests that the first six weeks of enrollment are critical to success. Because many students initiate heavy drinking during these early days of college, the potential exists for excessive…

  9. Precision frequency measurements of He,43 2 3P→3 3D transitions at 588 nm

    NASA Astrophysics Data System (ADS)

    Luo, Pei-Ling; Peng, Jin-Long; Hu, Jinmeng; Feng, Yan; Wang, Li-Bang; Shy, Jow-Tsong

    2016-12-01

    We report the frequency measurements of the 2 3P→3 3D transitions in He,43 at 588 nm using an optical frequency comb stabilized laser system. The Doppler-free spectra of the 2 3P→3 3D transitions are demonstrated in an rf discharged sealed-off helium cell using intermodulated fluorescence spectroscopy. The measured absolute frequency of the 4He2 3P0→3 3D1 transition is 510 059 755.352(28) MHz, which is more precise than the previous measurement by two orders of magnitude. The ionization energies of the 4He2 3P0 and 2 3S1 states can be derived from our result and agree very well with the previous experimental values. More importantly, the Lamb shift of the 2 3S1 state can be deduced to be 4057.086(34) MHz, which is two times more precise than the previous result. In addition, the absolute frequencies of the 2 3P0,1 /2→3 3D1,3 /2 , 2 3P0,1 /2→3 3D1,1 /2 , and 2 3P0,1 /2→3 3D2,3 /2 transitions in 3He are measured. Our precision surpasses the theoretical calculations by more than one to two orders of magnitude. The hyperfine separations of the 3 3D states in 3He and the frequency differences between 4He and 3He transitions are also presented.

  10. 43 CFR 4110.2-3 - Transfer of grazing preference.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Transfer of grazing preference. 4110.2-3... MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) GRAZING ADMINISTRATION-EXCLUSIVE OF ALASKA Qualifications and Preference § 4110.2-3 Transfer of grazing preference. (a) Transfers of grazing preference...

  11. 43 CFR 3107.2-3 - Leases capable of production.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Leases capable of production. 3107.2-3... or Renewal § 3107.2-3 Leases capable of production. No lease for lands on which there is a well... same, unless the lessee fails to place the lease in production within a period of not less than 60...

  12. 43 CFR 4610.2-3 - Approval of lease; renewal.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Approval of lease; renewal. 4610.2-3 Section 4610.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) LEASES OF GRAZING LAND-PIERCE ACT...

  13. 43 CFR 4610.2-3 - Approval of lease; renewal.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Approval of lease; renewal. 4610.2-3 Section 4610.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) LEASES OF GRAZING LAND-PIERCE ACT...

  14. 43 CFR 4610.2-3 - Approval of lease; renewal.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Approval of lease; renewal. 4610.2-3 Section 4610.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) LEASES OF GRAZING LAND-PIERCE ACT...

  15. 43 CFR 4610.2-3 - Approval of lease; renewal.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Approval of lease; renewal. 4610.2-3 Section 4610.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR RANGE MANAGEMENT (4000) LEASES OF GRAZING LAND-PIERCE ACT...

  16. 43 CFR 3140.2-3 - Application requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Application requirements. 3140.2-3 Section 3140.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND...

  17. 43 CFR 3140.2-3 - Application requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Application requirements. 3140.2-3 Section 3140.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND...

  18. 43 CFR 3140.2-3 - Application requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Application requirements. 3140.2-3 Section 3140.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND...

  19. 43 CFR 2920.2-3 - Other land use proposals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Other land use proposals. 2920.2-3 Section 2920.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) LEASES, PERMITS AND EASEMENTS...

  20. 43 CFR 2920.2-3 - Other land use proposals.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Other land use proposals. 2920.2-3 Section 2920.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) LEASES, PERMITS AND EASEMENTS...

  1. 43 CFR 3811.2-3 - Lands in Indian reservations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Lands in Indian reservations. 3811.2-3 Section 3811.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LANDS AND MINERALS SUBJECT TO...

  2. 43 CFR 3811.2-3 - Lands in Indian reservations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Lands in Indian reservations. 3811.2-3 Section 3811.2-3 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LANDS AND MINERALS SUBJECT TO...

  3. Striatal dopamine D2/3 receptor availability increases after long-term bariatric surgery-induced weight loss.

    PubMed

    van der Zwaal, Esther M; de Weijer, Barbara A; van de Giessen, Elsmarieke M; Janssen, Ignace; Berends, Frits J; van de Laar, Arnold; Ackermans, Mariette T; Fliers, Eric; la Fleur, Susanne E; Booij, Jan; Serlie, Mireille J

    2016-07-01

    In several studies reduced striatal dopamine D2/3 receptor (D2/3R) availability was reported in obese subjects compared to lean controls. Whether this is a reversible phenomenon remained uncertain. We previously determined the short-term effect of Roux-en-Y gastric bypass surgery (RYGB) on striatal D2/3R availability (using [(123)I]IBZM SPECT) in 20 morbidly obese women. Striatal D2/3R availability was lower compared to controls at baseline, and remained unaltered after 6 weeks, despite significant weight loss. To determine whether long-term bariatric surgery-induced weight loss normalizes striatal D2/3R binding, we repeated striatal D2/3R binding measurements at least 2 years after RYGB in 14 subjects of the original cohort. In addition, we assessed long-term changes in body composition, eating behavior and fasting plasma levels of leptin, ghrelin, insulin and glucose. Mean body mass index declined from 46±7kg/m(2) to 32±6kg/m(2), which was accompanied by a significant increase in striatal D2/3R availability (p=0.031). Striatal D2/3R availability remained significantly reduced compared to the age-matched controls (BMI 22±2kg/m(2); p=0.01). Changes in striatal D2/3R availability did not correlate with changes in body weight/fat, insulin sensitivity, ghrelin or leptin levels. Scores on eating behavior questionnaires improved and changes in the General Food Craving Questionnaire-State showed a borderline significant correlation with changes in striatal D2/3R availability. These findings show that striatal D2/3R availability increases after long-term bariatric-surgery induced weight loss, suggesting that reduced D2/3R availability in obesity is a reversible phenomenon.

  4. Determination of 2,3-dibromopropanol in air.

    PubMed

    Choudhary, G

    1987-09-01

    One of the starting materials for the preparation of TRIS-BP (tris-2,3-dibromopropanol phosphate), which is used in the treatment of fabrics and various materials to make them nonflammable, is 2,3-dibromopropanol. Because of the reported toxic nature of its parent phosphate compound, 2,3-dibromopropanol recently has been used by itself as a fire retardant. The manufacture and use of 2,3-dibromopropanol as a fire retardant, however, have been a matter of great concern in the workplace because of its mutagenic, carcinogenic and nephrotoxic nature. A sensitive air sampling and analytical method has been developed as part of a complete field survey protocol. This paper describes the development of an air sampling and gas-liquid chromatographic analysis procedure for 2,3-dibromopropanol. The detection limit for the method is 5 microg per sample and the relative standard deviation for the method is 5%.

  5. Pathogenesis of porcine epidemic diarrhea virus isolate (US/Iowa/18984/2013) in 3-week-old weaned pigs.

    PubMed

    Madson, D M; Magstadt, D R; Arruda, P H E; Hoang, H; Sun, D; Bower, L P; Bhandari, M; Burrough, E R; Gauger, P C; Pillatzki, A E; Stevenson, G W; Wilberts, B L; Brodie, J; Harmon, K M; Wang, C; Main, R G; Zhang, J; Yoon, K J

    2014-11-07

    Porcine epidemic diarrhea virus (PEDV) is associated with clinical diarrhea in naïve swine of all ages. This report describes timing of antibody generation and disease progression following infection with a US PEDV isolate by assessing fecal viral shedding, morphometric analysis of intestinal lesions, and magnitude of immunohistochemical staining. Sixty-three, 3-week-old pigs were randomly allocated into control (n=27) and challenged (n=36) groups. Challenged pigs were administered 1 mL of 1 × 10(3) PFU/mL of US/Iowa/18984/2013 PEDV isolate by oro-gastric gavage. Three control and four challenged pigs were necropsied on days post-inoculation (dpi) 1, 2, 3, 4, 7, and weekly thereafter, until study termination on dpi 35. Clinical disease, fecal shedding, body weight, and temperature were monitored during the study period. Diarrhea was observed in challenged pigs beginning for some on dpi 2, affecting a majority of pigs by dpi 6 and subsiding by dpi 10. Average daily gain was significantly lower (P<0.001) for one week post-infection in challenged pigs. PEDV was detected in feces by PCR on dpi 1 and continued in a subset of pigs until dpi 24. PEDV-specific antigen was detected in villous enterocytes of challenged pigs by immunohistochemistry (IHC) on dpi 1, 2, 3, 4, 7, and 14. Microscopic lesions included severe diffuse atrophic enteritis with significantly reduced (P<0.001) villous length observed on dpi 3, 4, and 7. Under the conditions of this study, fecal shedding of PEDV and IHC staining can precede and continue beyond the observation of clinical signs, thus increasing the risk of viral transmission.

  6. Does Shortening the School Week Impact Student Performance? Evidence from the Four-Day School Week

    ERIC Educational Resources Information Center

    Anderson, D. Mark; Walker, Mary Beth

    2015-01-01

    School districts use a variety of policies to close budget gaps and stave off teacher layoffs and furloughs. More schools are implementing four-day school weeks to reduce overhead and transportation costs. The four-day week requires substantial schedule changes as schools must increase the length of their school day to meet minimum instructional…

  7. PERSISTENT EFFECTS OF REPEATED INHALATION OF TOLUENE: 4 WEEKS VS. 13 WEEKS.

    EPA Science Inventory

    Understanding and predicting the extent of neurotoxic damage from repeated exposure to volatile organic compounds (VOCs) is a problem for many EPA programs. Eighty adult, male Long-Evans rats inhaled toluene (0, 10, 100, or 1000 ppm) 6 hr/day, 5 days/week for 4 weeks in a systema...

  8. Oral 4-week and 13-week toxicity studies of polyvinyl acetate vinyl laurate copolymer in rats.

    PubMed

    Messinger, Horst; Bär, Albert

    2014-10-01

    Polyvinyl acetate vinyl laurate copolymer (PVAcVL) is a useful component of gum base for chewing gum production. The safety of PVAcVL was examined in a 4-week and a 13-week oral toxicity study in rats. Finely powdered PVAcVL was administered with the diet at levels of 1.25%, 2.0% and 5% in the 4-week study and 1.25%, 2.5% and 5% in the 13-week study. There were no treatment related effects on mortality, bodyweight gains feed efficiency, ophthalmoscopic findings, hematological and clinical chemical parameters, neurobehavioral observations as well as gross and histopathological changes of standard organs and tissues. The highest dose tested in the 13-week study (3783 and 4396mg/kgbw/d for males and females, respectively) proved to be a NOAEL.

  9. Vehicle Technologies' Fact of the Week 2011

    SciTech Connect

    Davis, Stacy Cagle; Diegel, Susan W; Boundy, Robert Gary

    2012-04-01

    Each week the U.S. Department of Energy s Vehicle Technology Program (VTP) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/. These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current Fact is available Monday through Friday on the VTP homepage, but older Facts are archived and still available at: http://www1.eere.energy.gov/vehiclesandfuels/facts/. This report is a compilation of the Facts that were posted during calendar year 2011. The Facts were written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

  10. Vehicle Technologies’ Fact of the Week 2013

    SciTech Connect

    Davis, Stacy Cagle; Diegel, Susan W.; Moore, Sheila A.; Boundy, Robert Gary

    2014-04-01

    Each week the U.S. Department of Energy’s Vehicle Technology Office (VTO) posts a Fact of the Week on their website: http://www1.eere.energy.gov/vehiclesandfuels/ . These Facts provide statistical information, usually in the form of charts and tables, on vehicle sales, fuel economy, gasoline prices, and other transportation-related trends. Each Fact is a stand-alone page that includes a graph, text explaining the significance of the data, the supporting information on which the graph was based, and the source of the data. A link to the current week’s Fact is available on the VTO homepage, but older Facts are archived and still available at: http://www1.eere.energy.gov/vehiclesandfuels/facts/. This report is a compilation of the Facts that were posted during calendar year 2013. The Facts were written and prepared by staff in Oak Ridge National Laboratory's Center for Transportation Analysis.

  11. Prospective comparison of the diagnostic potential of real-time PCR, double-sandwich enzyme-linked immunosorbent assay for galactomannan, and a (1-->3)-beta-D-glucan test in weekly screening for invasive aspergillosis in patients with hematological disorders.

    PubMed

    Kawazu, Masahito; Kanda, Yoshinobu; Nannya, Yasuhito; Aoki, Katsunori; Kurokawa, Mineo; Chiba, Shigeru; Motokura, Toru; Hirai, Hisamaru; Ogawa, Seishi

    2004-06-01

    The establishment of an optimal noninvasive method for diagnosing invasive aspergillosis (IA) is needed to improve the management of this life-threatening infection in patients with hematological disorders, and a number of noninvasive tests for IA that target different fungal components, including galactomannan, (1-->3)-beta-d-glucan (BDG), and Aspergillus DNA, have been developed. In this study, we prospectively evaluated the diagnostic potential of three noninvasive tests for IA that were used in a weekly screening strategy: the double-sandwich enzyme-linked immunosorbent assay (ELISA) for galactomannan (Platelia Aspergillus), a real-time PCR assay for Aspergillus DNA (GeniQ-Asper), and an assay for BDG (beta-glucan Wako). We analyzed 149 consecutive treatment episodes in 96 patients with hematological disorders who were at high risk for IA and diagnosed 9 proven IA cases, 2 probable IA cases, and 13 possible invasive fugal infections. In a receiver-operating characteristic (ROC) analysis, the area under the ROC curve was greatest for ELISA, using two consecutive positive results (0.97; P = 0.036 for ELISA versus PCR, P = 0.055 for ELISA versus BDG). Based on the ROC curve, the cutoff for the ELISA could be reduced to an optical density index (O.D.I.) of 0.6. With the use of this cutoff for ELISA and cutoffs for PCR and BDG that give a comparable level of specificity, the sensitivity/specificity/positive predictive value/negative predictive value of the ELISA and the PCR and BDG tests were 1.00/0.93/0.55/1.00, 0.55/0.93/0.40/0.96, and 0.55/0.93/0.40/0.96, respectively. In conclusion, among these weekly screening tests for IA, the double-sandwich ELISA test was the most sensitive at predicting the diagnosis of IA in high-risk patients with hematological disorders, using a reduced cutoff of 0.6 O.D.I.

  12. Prospective Comparison of the Diagnostic Potential of Real-Time PCR, Double-Sandwich Enzyme-Linked Immunosorbent Assay for Galactomannan, and a (1→3)-β-d-Glucan Test in Weekly Screening for Invasive Aspergillosis in Patients with Hematological Disorders

    PubMed Central

    Kawazu, Masahito; Kanda, Yoshinobu; Nannya, Yasuhito; Aoki, Katsunori; Kurokawa, Mineo; Chiba, Shigeru; Motokura, Toru; Hirai, Hisamaru; Ogawa, Seishi

    2004-01-01

    The establishment of an optimal noninvasive method for diagnosing invasive aspergillosis (IA) is needed to improve the management of this life-threatening infection in patients with hematological disorders, and a number of noninvasive tests for IA that target different fungal components, including galactomannan, (1→3)-β-d-glucan (BDG), and Aspergillus DNA, have been developed. In this study, we prospectively evaluated the diagnostic potential of three noninvasive tests for IA that were used in a weekly screening strategy: the double-sandwich enzyme-linked immunosorbent assay (ELISA) for galactomannan (Platelia Aspergillus), a real-time PCR assay for Aspergillus DNA (GeniQ-Asper), and an assay for BDG (β-glucan Wako). We analyzed 149 consecutive treatment episodes in 96 patients with hematological disorders who were at high risk for IA and diagnosed 9 proven IA cases, 2 probable IA cases, and 13 possible invasive fugal infections. In a receiver-operating characteristic (ROC) analysis, the area under the ROC curve was greatest for ELISA, using two consecutive positive results (0.97; P = 0.036 for ELISA versus PCR, P = 0.055 for ELISA versus BDG). Based on the ROC curve, the cutoff for the ELISA could be reduced to an optical density index (O.D.I.) of 0.6. With the use of this cutoff for ELISA and cutoffs for PCR and BDG that give a comparable level of specificity, the sensitivity/specificity/positive predictive value/negative predictive value of the ELISA and the PCR and BDG tests were 1.00/0.93/0.55/1.00, 0.55/0.93/0.40/0.96, and 0.55/0.93/0.40/0.96, respectively. In conclusion, among these weekly screening tests for IA, the double-sandwich ELISA test was the most sensitive at predicting the diagnosis of IA in high-risk patients with hematological disorders, using a reduced cutoff of 0.6 O.D.I. PMID:15184460

  13. Synthesis of genistein 2,3-anhydroglycoconjugates -- potential antiproliferative agents.

    PubMed

    Goj, Katarzyna; Rusin, Aleksandra; Szeja, Wiesław; Kitel, Radosław; Komor, Roman; Grynkiewicz, Grzegorz

    2012-01-01

    The title compounds, variously protected 2.3-anhydrosugars linked with genistein through an alkyl chain, were synthesized in a sequence of reactions. First step involved Ferrier rearragement of 3,4-di-O-acetyl-L-rhamnal with 3-bromopropanol to obtain 2,3-unsaturated bromoalkylglycosides. The next step was epoxidation with m-CPBA and finally these compounds were connected with genistein in reaction of 7-O-genistein tetra-butylamonium salt with 2,3-anhydro bromoalkylglycosides. Obtained glycoconjugates differ in orientation of an oxirane ring and the protecting group in a sugar moiety. All compounds were tested in vitro for antiproliferative potential in cancer cells.

  14. The effect of intermittent use of occlusal splint devices on sleep bruxism: a 4-week observation with a portable electromyographic recording device.

    PubMed

    Matsumoto, H; Tsukiyama, Y; Kuwatsuru, R; Koyano, K

    2015-04-01

    This randomised controlled study investigated the effect of intermittent use of occlusal splints on sleep bruxism compared with that of continuous use by measuring masseter muscle electromyographic activity using a portable electromyographic recording system. Twenty bruxers were randomly allocated to the continuous group and intermittent group. Subjects in the continuous group wore stabilisation splints during sleep for 29 nights continuously, whereas those in the intermittent group wore splints during sleep every other week, that is they used splints on the 1st-7th, 15th-21st and 29th nights. Electromyographic activity of the masseter muscle during sleep was recorded for the following six time points: before (baseline), immediately after, and 1, 2, 3 and 4 weeks after the insertion of a stabilisation splint. The number of nocturnal masseter electromyographic events, duration and the total activity of sleep bruxism were analysed. In the continuous group, nocturnal masseter electromyographic events were significantly reduced immediately and 1 week after the insertion of the stabilisation splint, and duration was reduced immediately after the insertion (P < 0·05, Dunnett's test), but no reduction was observed at 2, 3 and 4 weeks after insertion. In the intermittent group, nocturnal masseter electromyographic events and duration were significantly reduced immediately after and also 4 weeks after insertion of the stabilisation splint (P < 0·05, Dunnett's test). The obtained results of the present exploratory trial indicate that the intermittent use of stabilisation splints may reduce sleep bruxism activity for a longer period compared with that of continuous use.

  15. Technical Fact Sheet – 1,2,3-Trichloropropane (TCP)

    EPA Pesticide Factsheets

    This fact sheet, developed by the U.S. Environmental Protection Agency (EPA) Federal Facilities Restoration and Reuse Office (FFRRO), provides a brief summary of the contaminant 1,2,3-trichloropropane (TCP), including physical and chemical properties;

  16. Technical Fact Sheet – 1,2,3-Trichloropropane (TCP)

    EPA Pesticide Factsheets

    This fact sheet, developed by the U.S. Environmental Protection Agency (EPA) Federal Facilities Restoration and Reuse Office (FFRRO), provides a brief summary of the contaminant 1,2,3-trichloropropane (TCP), including physical and chemical properties

  17. 34. DETAILS OF CAISSON FOR PIERS 2, 3, 4 AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. DETAILS OF CAISSON FOR PIERS 2, 3, 4 AND 5 TO BE BUILT ON SOIL OVERBURDEN - East Bloomsburg Bridge, Spanning Susquehanna River at Pennsylvania Route 487 (Legislative Route 283), Bloomsburg, Columbia County, PA

  18. 2,3-Butanediol Metabolism in the Acetogen Acetobacterium woodii

    PubMed Central

    Hess, Verena; Oyrik, Olga; Trifunović, Dragan

    2015-01-01

    The acetogenic bacterium Acetobacterium woodii is able to reduce CO2 to acetate via the Wood-Ljungdahl pathway. Only recently we demonstrated that degradation of 1,2-propanediol by A. woodii was not dependent on acetogenesis, but that it is disproportionated to propanol and propionate. Here, we analyzed the metabolism of A. woodii on another diol, 2,3-butanediol. Experiments with growing and resting cells, metabolite analysis and enzymatic measurements revealed that 2,3-butanediol is oxidized in an NAD+-dependent manner to acetate via the intermediates acetoin, acetaldehyde, and acetyl coenzyme A. Ethanol was not detected as an end product, either in growing cultures or in cell suspensions. Apparently, all reducing equivalents originating from the oxidation of 2,3-butanediol were funneled into the Wood-Ljungdahl pathway to reduce CO2 to another acetate. Thus, the metabolism of 2,3-butanediol requires the Wood-Ljungdahl pathway. PMID:25934628

  19. Nonlinear realizations of the W(2)3 algebra

    NASA Astrophysics Data System (ADS)

    Bellucci, S.; Gribanov, V.; Krivonos, S.; Pashnev, A.

    1994-08-01

    In this Letter we consider the nonlinear realizations of the classical Polyakov's algebra W(2)3. The coset space method and the covariant reduction procedure allow us to deduce the Boussinesq equation with interchanged space and evolution coordinates. By adding one more space coordinate and introducing two copies of the W(2)3 algebra, the same method yields the sl(3, R) Toda lattice equations.

  20. Cycloadditions of Noncomplementary Substituted 1,2,3-Triazines

    PubMed Central

    2015-01-01

    The scope of the [4 + 2] cycloaddition reactions of substituted 1,2,3-triazines, bearing noncomplementary substitution with electron-withdrawing groups at C4 and/or C6, is described. The studies define key electronic and steric effects of substituents impacting the reactivity, mode (C4/N1 vs C5/N2), and regioselectivity of the cycloaddition reactions of 1,2,3-triazines with amidines, enamines, and ynamines, providing access to highly functionalized heterocycles. PMID:25222918

  1. Age is not a determinant factor in susceptibility of broilers to H5N2 clade 2.3.4.4 high pathogenicity avian influenza virus.

    PubMed

    Bertran, Kateri; Lee, Dong-Hun; Balzli, Charles; Pantin-Jackwood, Mary J; Spackman, Erica; Swayne, David E

    2016-11-21

    In 2014-2015, the US experienced an unprecedented outbreak of H5 clade 2.3.4.4 highly pathogenic avian influenza (HPAI) virus. The H5N2 HPAI virus outbreak in the Midwest in 2015 affected commercial turkey and layer farms, but not broiler farms. To assess any potential genetic resistance of broilers and/or age-related effects, we investigated the pathogenesis and transmission of A/turkey/Minnesota/12582/2015 (H5N2) (Tk/MN/15) virus in commercial 5-week-old broilers, 8-week-old broilers, and >30-week-old broiler breeders. The mean bird lethal dose (BLD50) was 5.0 log10 mean egg infectious dose (EID50) for all age groups. The mean death time (MDT) was statistically not different among the three age groups, ranging between 3.2 and 4.8 days. All broilers that became infected shed high levels of virus with transmission to contacts and demonstrated severe pathology. Mortality and virus shedding results indicated that age is not a determinant factor in susceptibility of broilers to H5N2 clade 2.3.4.4 HPAI virus. Previously, the Tk/MN/15 virus had a BLD50 of 3.6 log10 EID50 and MDT of 2 days in White Leghorn chickens and a BLD50 of 5.0 log10 EID50 and MDT of 5.9 days in turkeys, suggesting that the broiler breed is less susceptible to Midwestern H5N2 virus than the layer breed but similarly susceptible to turkeys. Therefore, genetic resistance of broilers to infection may have accounted only partially for the lack of affected broiler farms in the Midwestern outbreaks, with other contributing factors such as fewer outside to on farm exposure to contacts, type of production management system or enhanced biosecurity.

  2. 77 FR 31143 - Emergency Medical Services Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... President Proclamation 8824--Emergency Medical Services Week, 2012 Proclamation 8825--National Safe Boating Week, 2012 Proclamation 8826--National Small Business Week, 2012 Proclamation 8827--World Trade Week... Medical Services Week, 2012 By the President of the United States of America A Proclamation Day and...

  3. Joint Eglin Acoustic Week III Data Report

    NASA Technical Reports Server (NTRS)

    Watts, Michael E.; Conner, David A.; Smith, Charles D.

    2010-01-01

    A series of three flight tests have been conducted at an Eglin Air Force Base remote test range located in the Florida panhandle. The first was the "Acoustics Week" flight test conducted in September 2003. The second was the NASA Heavy Lift Rotorcraft Acoustic Flight Test conducted in October-November 2005. The most recent was the Eglin Acoustic Week III test conducted in August-September 2007. This series of tests acquired acoustic data for a number of rotary and fixed wing aircraft and are used to generate noise semi-spheres used in predicting the acoustic footprint for prescribed flight operations. This extensive database can be used to determine the impact of flight operations on communities around a terminal area as well as for prediction code validations. Another valuable use of the semi-spheres is determining the long-range propagation of noise for civilian and military purposes. This paper describes the third test in this series. Data described in this report were acquired during testing of the MD-902 and Mi-8M aircraft. In addition, data acquired during a set of atmospheric propagation tests is also described.

  4. Access to transport for women with hypovolemic shock differs according to weeks of pregnancy☆

    PubMed Central

    Butrick, Elizabeth; Penn, Amy; Itakura, Kaoru; Mkumba, Gricelia; Winter, Kelly; Amafumba, Rhoda; Miller, Suellen

    2014-01-01

    Objective To examine whether women with hypovolemic shock secondary to obstetric hemorrhage are transported to referral hospitals differently depending on weeks of pregnancy in Zambia. Methods In a retrospective study, transport type, wait time, and transit time were assessed for women with obstetric hemorrhage and hypovolemic shock transported from 26 primary health centers to three referral hospitals during 2007–2011. A mean arterial pressure of less than 60 mm Hg was used to indicate severe shock. Women were split into two categories on the basis of the number of weeks of pregnancy (<24 weeks vs ≥24 weeks). Results Overall, 616 women were included. Mode of transport differed significantly by group (P<0.001). 414 (93.0%) of 445 women at 24 weeks of pregnancy or more were transported by ambulance versus 114 (66.7%) of 171 women at less than 24 weeks. Among those in severe shock, 106 (93.0%) of 114 women at 24 weeks of pregnancy or more were transported in ambulances versus 26 (52.0%) of 50 women at less than 24 weeks (P<0.001). Conclusion Women at 24 weeks of pregnancy or more were given preference for ambulance transport even when signs of shock were equivalent. Policy-makers aiming to lower maternal mortality need to address transport issues regardless of the etiology of hemorrhage or week of pregnancy. PMID:25022343

  5. Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline

    DOEpatents

    Field, George; Hammond, Peter R.

    1994-01-01

    Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired quinoline and a second method in which tetrahydroquinoline is nitrated and hydrogenated and then hydrolyzed to obtain the desire quinoline. 7-hydroxy-1,2,3,4-tetrahydroquinoline is used in the efficient synthesis of four lasing dyes of the rhodamine class.

  6. Method for preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline from 1,2,3,4-tetrahydroquinoline

    DOEpatents

    Field, G.; Hammond, P.R.

    1994-02-01

    Methods for the efficient preparation of 7-hydroxy-1,2,3,4-tetrahydroquinoline include a first method in which the acylation of m-aminophenol obtains a lactam which is reduced to give the desired quinoline and a second method in which tetrahydroquinoline is nitrated and hydrogenated and then hydrolyzed to obtain the desire quinoline. 7-hydroxy-1,2,3,4-tetrahydroquinoline is used in the efficient synthesis of four lasing dyes of the rhodamine class.

  7. A randomized Phase III trial of weekly or 3-weekly doses of nab-paclitaxel versus weekly doses of Cremophor-based paclitaxel in patients with previously treated advanced gastric cancer (ABSOLUTE Trial).

    PubMed

    Koizumi, Wasaburo; Morita, Satoshi; Sakata, Yuh

    2015-03-01

    Paclitaxel is an agent widely used in second-line chemotherapy for advanced gastric cancer. The aim of this trial is to evaluate the efficacy and safety of 3-weekly or weekly doses of nanoparticle albumin-bound-paclitaxel compared with weekly doses of Cremophor-based paclitaxel in patients with unresectable or recurrent gastric cancer refractory to first-line chemotherapy comprising fluoropyrimidines. A total of 730 patients will be enrolled from 72 institutions. The primary endpoint is the overall survival, and the secondary endpoints are progression-free survival, time to treatment failure, overall response rate, disease control rate, quality of life (by using the EQ-5D system) and safety.

  8. 76 FR 30491 - National Hurricane Preparedness Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... President Proclamation 8679--National Hurricane Preparedness Week, 2011 Proclamation 8680--National Safe Boating Week, 2011 Proclamation 8681--Armed Forces Day, 2011 Proclamation 8682--To Modify the Rules of...

  9. Production of 2,3-butanediol by a low-acid producing Klebsiella oxytoca NBRF4.

    PubMed

    Han, Sung-Hyuk; Lee, Jung-Eun; Park, Kyungmoon; Park, Yong-Cheol

    2013-01-25

    2,3-Butanediol (2,3-BDO) is a value-added chemical with great potential for the industrial production of synthetic rubber, plastic and solvent. For microbial production of 2,3-BDO, in this study, Klebsiella oxytoca NBRF4 was constructed by chemical mutation and screening against NaBr, NaBrO(3) and fluoroacetate. Among metabolic enzymes involved in the production of lactate, acetate and 2,3-BDO, K. oxytoca NBRF4 possessed 1.2 times lower specific activities of lactate dehydrogenase and phosphotransacetylase, and 22% higher specific acetoin reductase activity than the K. oxytoca ATCC43863 control strain. A series of batch fermentations in a defined medium and application of a statistical tool of response surface method led to the determination of optimal culture conditions: 10% dissolved oxygen level, pH 4.3 and 38°C. The actual results of batch fermentation at the optimal conditions using 44 g/L glucose were coincident with the predetermined values: 14.4 g/L 2,3-BDO concentration, 0.32 g/g yield. To increase 2,3-BDO titer, fed-batch fermentation of K. oxytoca NBRF4 was performed by an intermittent feeding of 800 g/L glucose to control its concentration around 5-20 g/L in the culture broth. Finally, 34.2g/L 2,3-BDO concentration and 0.35 g/g yield were obtained without organic acid production in 70 hours of the fed-batch culture, which were 2.4 and 1.2 times higher than those of the batch fermentation using 44 g/L glucose.

  10. After Opportunity's First Drive in Six Weeks

    NASA Technical Reports Server (NTRS)

    2007-01-01

    NASA's Mars Exploration Rover Opportunity used its front hazard-identification camera to obtain this image at the end of a drive on the rover's 1,271st sol, or Martian day (Aug. 21, 2007).

    Due to sun-obscuring dust storms limiting the rover's supply of solar energy, Opportunity had not driven since sol 1,232 (July 12, 2007). On sol 1,271, after the sky above Opportunity had been gradually clearing for more than two weeks, the rover rolled 13.38 meters (44 feet). Wheel tracks are visible in front of the rover because the drive ended with a short test of driving backwards.

    Opportunity's turret of four tools at the end of the robotic arm fills the center of the image. Victoria Crater, site of the rover's next science targets, lies ahead.

  11. Twelve- and 52-week safety of albuterol multidose dry powder inhaler in patients with persistent asthma

    PubMed Central

    Raphael, Gordon; Taveras, Herminia; Iverson, Harald; O’Brien, Christopher; Miller, David

    2016-01-01

    Abstract Objective: Evaluate the safety of albuterol multidose dry powder inhaler (MDPI), a novel, inhalation-driven device that does not require coordination of actuation with inhalation, in patients with persistent asthma. Methods: We report pooled safety data from two 12-week, multicenter, randomized, double-blind, repeat-dose, parallel-group studies and the 12-week double-blind phase of a 52-week multicenter safety study as well as safety data from the 40-week open-label phase of the 52-week safety study. In each study, eligible patients aged ≥12 years with persistent asthma received placebo MDPI or albuterol MDPI 180 µg (2 inhalations × 90 µg/inhalation) 4 times/day for 12 weeks. In the 40-week open-label phase of the 52-week safety study, patients received albuterol MDPI 180 μg (2 inhalations × 90 μg/inhalation) as needed (PRN). Results: During both 12-week studies and the 12-week double-blind phase of the 52-week study, adverse events were more common with placebo MDPI (50%; n = 333) than albuterol MDPI (40%; n = 321); most frequent were upper respiratory tract infection (placebo MDPI 11%, albuterol MDPI 10%), nasopharyngitis (6%, 5%), and headache (6%, 4%). Incidences of β2-agonist-related events (excluding headache) during the pooled 12-week dosing periods were low (≤1%) in both groups. The safety profile with albuterol MDPI PRN during the 40-week open-label phase [most frequent adverse events: nasopharyngitis (12%), sinusitis (11%), upper respiratory tract infection (9%)] was similar to that observed during the 12-week pooled analysis. Conclusions: The safety profile of albuterol MDPI 180 μg in these studies was comparable with placebo MDPI and consistent with the well-characterized profile of albuterol in patients with asthma. PMID:26369589

  12. Winter fuels report: Week ending October 19, 1990

    SciTech Connect

    Not Available

    1990-10-25

    The Winter Fuels Report is intended to provide concise, timely information to the industry, the press, policymakers, consumers, analysts, and state and local governments on the following topics: distillate fuel oil net production, imports and stocks for all PADD's and product supplied on the US level; propane net production, imports and stocks for Petroleum Administration for Defense Districts (PADD) I, II, and III; natural gas supply and disposition and underground storage for the United States and consumption for all PADD's; residential and wholesale pricing data for propane and heating oil for those states participating in the joint Energy Information Administration (EIA)/State Heating Oil and Propane Program; crude oil and petroleum price comparisons for the United States and selected cities; and US total heating degree-days by city. This report will be published weekly by the EIA starting the first week in October 1990 and will continue until the first week in April 1991. The data will also be available electronically after 5:00 pm on Thursday during the heating season through the EIA Electronic Publication System (EPUB).

  13. Winter fuels report, week ending October 5, 1990

    SciTech Connect

    Not Available

    1990-10-11

    The Winter Fuels Report is intended to provide concise, timely information to the industry, the press, policymakers, consumers, analysts, and state and local governments on the following topics: distillate fuel oil net production, imports and stocks for all PADD's and product supplied on a US level; propane net production, imports and stocks for Petroleum Administration for Defense Districts (PADD) I, II, and III; natural gas supply and disposition and underground storage, for the United States and consumption for all PADD's; residential and wholesale pricing data for propane and heating oil for those states participating in the joint Energy Information Administration (EIA)/State Heating Oil and Propane Program; crude oil and petroleum price comparisons for the United States and selected cities; and US total heating degree-days by city. This report will be published weekly by the EIA starting the first week in October 1990 and will continue until the first week in April 1991. The data will also be electronically after 5:00 p.m. on Thursday during the heating season through the EIA Electronic Publication System (EPUB). See page ii for details. 12 tabs.

  14. Winter fuels report, week ending October 20, 1995

    SciTech Connect

    1995-11-01

    Weekly estimates of distillate stocks (131.6 MMB) are now 2.1 MMB below the lower bound of the three year average, and the current rate of increase is also lower than the average of the past three years. Heating fuels are 48% of the total inventory and have fallen 1.3 MMB during the past week. Distillate production dipped while demand increased. The supply of propane for the current week declined 1.5 MMB from the prior reporting period but is in the normal range for the time of the year. The natural gas supply available for distribution in August 1995 was estimated to be 1,795 BCF, which was almost unchanged from the previous year. The August 1995 consumption of 1,502 BCF was 6% greater than the previous year. This gas volume included 276 BCF injected into underground storage and 16 BCF exported. In July 1995, major gas pipeline companies paid an average of $1.91/KCF for gas purchased from domestic producers, which was a decrease from $2.03 in the previous month. The price for imported gas was $1.10/KCF. Heating oil prices showed little movement during this period, as did propane prices.

  15. Knee Extension Range of Motion at 4 Weeks Is Related to Knee Extension Loss at 12 Weeks After Anterior Cruciate Ligament Reconstruction

    PubMed Central

    Noll, Sarah; Garrison, J. Craig; Bothwell, James; Conway, John E.

    2015-01-01

    Background: The anterior cruciate ligament (ACL) is commonly torn, and surgical reconstruction is often required to allow a patient to return to their prior level of activity. Avoiding range of motion (ROM) loss is a common goal, but little research has been done to identify when ROM loss becomes detrimental to a patient’s future function. Purpose: To determine whether there is a relationship between early knee side-to-side extension difference after ACL reconstruction and knee side-to-side extension difference at 12 weeks. The hypothesis was that early (within the first 8 weeks) knee side-to-side extension difference will be predictive of knee side-to-side extension difference seen at 12 weeks. Study Design: Cohort study; Level of evidence, 3. Methods: Knee side-to-side extension difference measures were taken on 74 patients undergoing ACL reconstruction rehabilitation at the initial visit and 4, 8, and 12 weeks postoperatively. Visual analog scores (VAS) and International Knee Documentation Committee (IKDC) scores were also recorded at these time frames. Results: There was a strong relationship between knee extension ROM at 4 and 12 weeks (r = 0.639, P < .001) and 8 and 12 weeks (r = 0.742, P < .001). When the variables of knee extension ROM at initial visit and 4 and 8 weeks were entered into a regression analysis, the predictor variable explained 61% (R2 = 0.611) of variance for knee extension ROM at 12 weeks, with 4 weeks (R2 = 0.259) explaining the majority of this variance. Conclusion: This study found that a patient’s knee extension at 4 weeks was strongly correlated with knee extension at 12 weeks. Clinical Relevance: This information may be useful for clinicians treating athletic patients who are anxious for return to sport by providing them an initial goal to work toward in hopes of ensuring successful rehabilitation of their knee. PMID:26675061

  16. AM2 3-4 Alternate Lay Pattern Evaluation

    DTIC Science & Technology

    2014-09-01

    ER D C/ G SL T R- 14 -3 8 Airfield Damage Repair Modernization Program AM2 3-4 Alternate Lay Pattern Evaluation G eo te ch ni ca l a nd...Airfield Damage Repair Modernization Program ERDC/GSL TR-14-38 September 2014 AM2 3-4 Alternate Lay Pattern Evaluation Timothy W. Rushing, Lyan...brickwork pattern. Therefore, the 3-4 alternate lay pattern was designed to allow Marines to use any mats on hand to fill in designated portions of the

  17. SORPTION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN FROM WATER BY SURFACE SOILS

    EPA Science Inventory

    The sorption of l4C-labeled 2,3,7,8-tetrachlorodibenzo- p-dioxin (TCDD) from water by two uncontaminated surface soils from the Times Beach, MO, area was evalu- ated by using batch shake testing. Sorption isotherm plots for the soil with the lower fraction organic carbon (f,) wer...

  18. Eight-Week Traditional Mat Pilates Training-Program Effects on Adult Fitness Characteristics

    ERIC Educational Resources Information Center

    Rogers, Kate; Gibson, Ann L.

    2009-01-01

    We investigated responses of adult, novice practitioners (n = 9) to an 8-week traditional mat Pilates program (P) that met 1 hr/day three times/week. Classes consisted primarily of beginner and intermediate level exercises. Compared to an active control group (C; n = 13) that showed no improvements, those in P significantly (p less than 0.05)…

  19. 3 CFR 8906 - Proclamation 8906 of November 16, 2012. National Family Week, 2012

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... Finally, at a time when many of our military families are stretched thin, we are mobilizing communities... Family Week, 2012 8906 Proclamation 8906 Presidential Documents Proclamations Proclamation 8906 of November 16, 2012 Proc. 8906 National Family Week, 2012By the President of the United States of America...

  20. Efficacy of a single, weekly dose of recombinant erythropoietin in myelodysplastic syndromes.

    PubMed

    Musto, Pellegrino; Falcone, Antonietta; Sanpaolo, Grazia; Bodenizza, Carlo; La Sala, Antonio; Perla, Gianni; Carella, Angelo Michele

    2003-07-01

    Thirteen patients with low-to-intermediate risk myelodysplastic syndrome (MDS) received recombinant erythropoietin (r-EPO) at the single, weekly dose of 40.000 U for at least 8 weeks. Five patients (38.4%) achieved a major erythroid response (increased haemoglobin levels > 2 g/dl and/or transfusion independence), which is currently maintained after 3-11 months, without modification of r-EPO dose. This study suggests that 40.000 U r-EPO given once a week may be at least as effective as the more frequent (daily or three times a week) administrations of the drug usually employed in MDS patients.

  1. Keeping Seniors Engaged During The Last Week Of School

    NASA Astrophysics Data System (ADS)

    Haff, Thomas F.

    2006-12-01

    During the last week of classes at Issaquah High School, the students are pulled in lots of different directions as they get ready for graduation day. Even amid senior teas, yearbook signing, photos, graduation practice and such, the students at I H S are still engaged to the very last day doing meaningful physics with the “Physics Scavenger Hunt”. This time tested activity has been a tradition at I H S and something the students actually look forward to. Last year, about twenty students stayed after school on the final day of classes just to put on their final touches. This activity may be for you.

  2. The Greatest Educational Change America Has Ever Seen, 2003: Lesson Plans for Grades 2-3.

    ERIC Educational Resources Information Center

    United States Mint (Dept. of Treasury), Washington, DC.

    The United States Mint 50 State Quarters Program launched a 10-year initiative in 1999, commemorating each of the nation's states in the order they were admitted into the Union. Approximately every 10 weeks (5 times a year) through 2008, a new limited-edition quarter that displays an individual state's design is released into general circulation.…

  3. Special Relativity in Week One: 3) Introducing the Lorentz Contraction

    NASA Astrophysics Data System (ADS)

    Huggins, Elisha

    2011-05-01

    This is the third of four articles on teaching special relativity in the first week of an introductory physics course.1,2 With Einstein's second postulate that the speed of light is the same to all observers, we could use the light pulse clock to introduce time dilation. But we had difficulty introducing the Lorentz contraction until we saw the movie "Time Dilation, an Experiment with Mu-Mesons" by David Frisch and James Smith.3,4 The movie demonstrates that time dilation and the Lorentz contraction are essentially two sides of the same coin. Here we take the muon's point of view for a more intuitive understanding of the Lorentz contraction, and use the results of the movie to provide an insight into the way we interpret experimental results involving special relativity.

  4. 40 CFR 35.909 - Step 2+3 grants.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.909 Step 2+3 grants. (a) Authority... design (step 2) and construction (step 3) of a waste water treatment works. (b) Limitations. The Regional... disaggregations thereof); (2) The treatment works has an estimated total step 3 construction cost of $2 million...

  5. 40 CFR 35.909 - Step 2+3 grants.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.909 Step 2+3 grants. (a) Authority... design (step 2) and construction (step 3) of a waste water treatment works. (b) Limitations. The Regional... disaggregations thereof); (2) The treatment works has an estimated total step 3 construction cost of $2 million...

  6. 40 CFR 35.909 - Step 2+3 grants.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.909 Step 2+3 grants. (a) Authority... design (step 2) and construction (step 3) of a waste water treatment works. (b) Limitations. The Regional... disaggregations thereof); (2) The treatment works has an estimated total step 3 construction cost of $2 million...

  7. 40 CFR 35.909 - Step 2+3 grants.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.909 Step 2+3 grants. (a) Authority... design (step 2) and construction (step 3) of a waste water treatment works. (b) Limitations. The Regional... disaggregations thereof); (2) The treatment works has an estimated total step 3 construction cost of $2 million...

  8. 40 CFR 35.909 - Step 2+3 grants.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.909 Step 2+3 grants. (a) Authority... design (step 2) and construction (step 3) of a waste water treatment works. (b) Limitations. The Regional... disaggregations thereof); (2) The treatment works has an estimated total step 3 construction cost of $2 million...

  9. Substrate Oxidation by Indoleamine 2,3-Dioxygenase

    PubMed Central

    Booth, Elizabeth S.; Basran, Jaswir; Lee, Michael; Handa, Sandeep; Raven, Emma L.

    2015-01-01

    The kynurenine pathway is the major route of l-tryptophan (l-Trp) catabolism in biology, leading ultimately to the formation of NAD+. The initial and rate-limiting step of the kynurenine pathway involves oxidation of l-Trp to N-formylkynurenine. This is an O2-dependent process and catalyzed by indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase. More than 60 years after these dioxygenase enzymes were first isolated (Kotake, Y., and Masayama, I. (1936) Z. Physiol. Chem. 243, 237–244), the mechanism of the reaction is not established. We examined the mechanism of substrate oxidation for a series of substituted tryptophan analogues by indoleamine 2,3-dioxygenase. We observed formation of a transient intermediate, assigned as a Compound II (ferryl) species, during oxidation of l-Trp, 1-methyl-l-Trp, and a number of other substrate analogues. The data are consistent with a common reaction mechanism for indoleamine 2,3-dioxygenase-catalyzed oxidation of tryptophan and other tryptophan analogues. PMID:26511316

  10. The electron paramagnetic resonance spectrum of Ag2 3

    NASA Astrophysics Data System (ADS)

    van der Pol, A.; Reijersen, E. J.; de Boer, E.; Wasowicz, T.; Michalik, J.

    A highly resolved EPR spectrum of the silver trimer 109Ag2+3, present in 109Ag1-NaA zeolite, has been measured. The spectrum is characterized by an axially symmetric spin Hamiltonian having and for each of the 109Ag nuclei tMPH0037_images.

  11. Anxiety Self Report (ASR (1,2,3,4,). X

    ERIC Educational Resources Information Center

    Parsons, Jane S.

    The Anxiety Self Report (ASR 1,2,3,4) is provided, followed by information about the report. The ASR is discussed as to its development, description, response bias, scoring procedures, reliability, stability, validity, and correlation between the ASR and the Manifest Anxiety Scale. (For related documents, see TM 002 928, 929.) (DB)

  12. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 2 2010-01-01 2010-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  13. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 2 2014-01-01 2014-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  14. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 2 2013-01-01 2013-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  15. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 2 2012-01-01 2012-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  16. 15 CFR Supplement Nos. 2-3 to Part... - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 2 2011-01-01 2011-01-01 false Nos. Supplement Nos. 2-3 to Part 716 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE CHEMICAL WEAPONS CONVENTION REGULATIONS INITIAL AND...

  17. Accident sequence precursor analysis level 2/3 model development

    SciTech Connect

    Lui, C.H.; Galyean, W.J.; Brownson, D.A.

    1997-02-01

    The US Nuclear Regulatory Commission`s Accident Sequence Precursor (ASP) program currently uses simple Level 1 models to assess the conditional core damage probability for operational events occurring in commercial nuclear power plants (NPP). Since not all accident sequences leading to core damage will result in the same radiological consequences, it is necessary to develop simple Level 2/3 models that can be used to analyze the response of the NPP containment structure in the context of a core damage accident, estimate the magnitude of the resulting radioactive releases to the environment, and calculate the consequences associated with these releases. The simple Level 2/3 model development work was initiated in 1995, and several prototype models have been completed. Once developed, these simple Level 2/3 models are linked to the simple Level 1 models to provide risk perspectives for operational events. This paper describes the methods implemented for the development of these simple Level 2/3 ASP models, and the linkage process to the existing Level 1 models.

  18. 2,3,7,8-Tetrachlorodibenzo-p-dioxin

    Integrated Risk Information System (IRIS)

    2,3,7,8 - Tetrachlorodibenzo - p - dioxin ( TCDD ) ; CASRN 1746 - 01 - 6 This document has been provided for review to EPA scientists , interagency reviewers from other federal agencies and White House offices , and the public , and peer reviewed by independent scientists external to EPA . Sections

  19. 42 CFR 2.3 - Purpose and effect.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... ALCOHOL AND DRUG ABUSE PATIENT RECORDS Introduction § 2.3 Purpose and effect. (a) Purpose. Under the... use of alcohol and drug abuse patient records which are maintained in connection with the performance of any federally assisted alcohol and drug abuse program. The regulations specify: (1)...

  20. 42 CFR 2.3 - Purpose and effect.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... ALCOHOL AND DRUG ABUSE PATIENT RECORDS Introduction § 2.3 Purpose and effect. (a) Purpose. Under the... use of alcohol and drug abuse patient records which are maintained in connection with the performance of any federally assisted alcohol and drug abuse program. The regulations specify: (1)...

  1. 13. PRATT STREET BULKHEAD: SECTIONS 2, 3, 4, 5, AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. PRATT STREET BULKHEAD: SECTIONS 2, 3, 4, 5, AND 6, DRAWER 10, PLAN NO. 1, 1 IN. = 15 FT. AND 1/2 IN. = 1 FT., APRIL 25, 1906, DRAWING SHOWS DESIGN FOR PRATT STREET BULKHEAD BETWEEN PIERS - Baltimore Inner Harbor, Pier 5, South of Pratt Street between Market Place & Concord Street, Baltimore, Independent City, MD

  2. Indeno[1,2,3-cd]pyrene

    Integrated Risk Information System (IRIS)

    Indeno [ 1,2,3 - cd ] pyrene ; CASRN 193 - 39 - 5 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Nonc

  3. 42 CFR 2.3 - Purpose and effect.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... section); (2) Disclosures which may be made with written patient consent and the form of the written consent in subpart C; (3) Disclosures which may be made without written patient consent or an authorizing... ALCOHOL AND DRUG ABUSE PATIENT RECORDS Introduction § 2.3 Purpose and effect. (a) Purpose. Under...

  4. 42 CFR 2.3 - Purpose and effect.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... section); (2) Disclosures which may be made with written patient consent and the form of the written consent in subpart C; (3) Disclosures which may be made without written patient consent or an authorizing... ALCOHOL AND DRUG ABUSE PATIENT RECORDS Introduction § 2.3 Purpose and effect. (a) Purpose. Under...

  5. 42 CFR 2.3 - Purpose and effect.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... section); (2) Disclosures which may be made with written patient consent and the form of the written consent in subpart C; (3) Disclosures which may be made without written patient consent or an authorizing... ALCOHOL AND DRUG ABUSE PATIENT RECORDS Introduction § 2.3 Purpose and effect. (a) Purpose. Under...

  6. Lifetime measurement of the metastable 2 3P 0 state in He-like uranium

    NASA Astrophysics Data System (ADS)

    Toleikis, S.; Manil, B.; Bednarz, G.; Berdermann, E.; Beyer, H. F.; Bosch, F.; Bräuning-Demian, A.; Gumberidze, A.; Indelicato, P.; Kozhuharov, C.; Liesen, D.; Marrus, R.; Mokler, P. H.; Stachura, Z.; Stöhlker, T.; Warczak, A.

    2005-07-01

    The lifetime of the 2 3P0 state in He-like uranium has been measured in a beam-foil time-of-flight experiment at the Gesellschaft für Schwerionenforschung accelerator facility with the result τ(2 3P0) = 58.2(9.5) ps. With the measured lifetime it is possible to derive a value of Δ E2s Lamb = 76. 3 ± 20. 6 eV for the n = 2 Lamb shift in uranium.

  7. Physical and psychological benefits of once-a-week Pilates exercises in young sedentary women: A 10-week longitudinal study.

    PubMed

    Tolnai, Nóra; Szabó, Zsófia; Köteles, Ferenc; Szabo, Attila

    2016-09-01

    Pilates exercises have several demonstrated physical and psychological benefits. To date, most research in this context was conducted with symptomatic or elderly people with few dependent measures. The current study examined the chronic or longitudinal effects of very low frequency, once a week, Pilates training on several physical and psychological measures, over a 10-week intervention, in young, healthy, and sedentary women. Further, the study gauged the acute effects of Pilates exercises on positive- and negative affect in 10 exercise sessions. Compared to a control group, the Pilates group exhibited significant improvements in skeletal muscle mass, flexibility, balance, core- and abdominal muscle strength, body awareness, and negative affect. This group also showed favorable changes in positive (22.5% increase) and negative affect (12.2% decrease) in nine out of ten exercise sessions. This work clearly demonstrates the acute and chronic benefits of Pilates training on both physical and psychological measures. It also reveals that even only once a week Pilates training is enough to trigger detectable benefits in young sedentary women. While this frequency is below the required levels of exercise for health, it may overcome the 'lack of time' excuse for not exercising and subsequently its tangible benefits may positively influence one's engagement in more physical activity.

  8. Professional Development and National Science Week.

    ERIC Educational Resources Information Center

    Jones, Alison

    1999-01-01

    Summarizes the events that took place at the Primary Science Seminar held by the Science Teachers' Association of Western Australia (STAWA). Features instructions for seven time-related activities taught at the seminar including Sundials, Water Clock, Sand Timer, Pendulum, Tornado Timer, Marble Timer, and A Matter of Timing. (WRM)

  9. The Geometry of Almost Einstein (2, 3, 5) Distributions

    NASA Astrophysics Data System (ADS)

    Sagerschnig, Katja; Willse, Travis

    2017-01-01

    We analyze the classic problem of existence of Einstein metrics in a given conformal structure for the class of conformal structures inducedf Nurowski's construction by (oriented) (2, 3, 5) distributions. We characterize in two ways such conformal structures that admit an almost Einstein scale: First, they are precisely the oriented conformal structures c that are induced by at least two distinct oriented (2, 3, 5) distributions; in this case there is a 1-parameter family of such distributions that induce c. Second, they are characterized by the existence of a holonomy reduction to SU(1, 2), SL(3, R), or a particular semidirect product SL(2, R) ltimes Q_+, according to the sign of the Einstein constant of the corresponding metric. Via the curved orbit decomposition formalism such a reduction partitions the underlying manifold into several submanifolds and endows each ith a geometric structure. This establishes novel links between (2, 3, 5) distributions and many other geometries - several classical geometries among them - including: Sasaki-Einstein geometry and its paracomplex and null-complex analogues in dimension 5; Kähler-Einstein geometry and its paracomplex and null-complex analogues, Fefferman Lorentzian conformal structures, and para-Fefferman neutral conformal structures in dimension 4; CR geometry and the point geometry of second-order ordinary differential equations in dimension 3; and projective geometry in dimension 2. We describe a generalized Fefferman construction that builds from a 4-dimensional Kähler-Einstein or para-Kähler-Einstein structure a family of (2, 3, 5) distributions that induce the same (Einstein) conformal structure. We exploit some of these links to construct new examples, establishing the existence of nonflat almost Einstein (2, 3, 5) conformal structures for which the Einstein constant is positive and negative.

  10. 78 FR 30723 - National Safe Boating Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... May 22, 2013 Part IV The President Proclamation 8981--National Safe Boating Week, 2013 Proclamation 8982--Emergency Medical Services Week, 2013 Proclamation 8983--World Trade Week, 2013 Proclamation 8984...;The President ] Proclamation 8981 of May 17, 2013 National Safe Boating Week, 2013 By the President...

  11. 76 FR 29131 - Emergency Medical Services Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-19

    ... May 19, 2011 Part V The President Proclamation 8674--Emergency Medical Services Week, 2011 Proclamation 8675--National Defense Transportation Day and National Transportation Week, 2011 Proclamation 8676--Peace Officers Memorial Day and Police Week, 2011 Proclamation 8677--World Trade Week, 2011 Notice...

  12. 77 FR 72679 - Minority Enterprise Development Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-05

    ... Documents#0;#0; ] Proclamation 8912 of November 30, 2012 Minority Enterprise Development Week, 2012 By the... Development Week, let us honor the role America's minority-owned businesses play in spurring our prosperity... Minority Enterprise Development Week. I call upon all Americans to celebrate this week with...

  13. 20 CFR 625.6 - Weekly amount; jurisdictions; reductions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... DISASTER UNEMPLOYMENT ASSISTANCE § 625.6 Weekly amount; jurisdictions; reductions. (a) In all States... worker or unemployed self-employed individual for a week of total unemployment shall be the weekly amount... provisions of the applicable State law for a week of total unemployment. In no event shall such amount be...

  14. 20 CFR 625.6 - Weekly amount; jurisdictions; reductions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... DISASTER UNEMPLOYMENT ASSISTANCE § 625.6 Weekly amount; jurisdictions; reductions. (a) In all States... worker or unemployed self-employed individual for a week of total unemployment shall be the weekly amount... provisions of the applicable State law for a week of total unemployment. In no event shall such amount be...

  15. 20 CFR 625.6 - Weekly amount; jurisdictions; reductions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... DISASTER UNEMPLOYMENT ASSISTANCE § 625.6 Weekly amount; jurisdictions; reductions. (a) In all States... worker or unemployed self-employed individual for a week of total unemployment shall be the weekly amount... provisions of the applicable State law for a week of total unemployment. In no event shall such amount be...

  16. 20 CFR 625.6 - Weekly amount; jurisdictions; reductions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... DISASTER UNEMPLOYMENT ASSISTANCE § 625.6 Weekly amount; jurisdictions; reductions. (a) In all States... worker or unemployed self-employed individual for a week of total unemployment shall be the weekly amount... provisions of the applicable State law for a week of total unemployment. In no event shall such amount be...

  17. 20 CFR 625.6 - Weekly amount; jurisdictions; reductions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... DISASTER UNEMPLOYMENT ASSISTANCE § 625.6 Weekly amount; jurisdictions; reductions. (a) In all States... worker or unemployed self-employed individual for a week of total unemployment shall be the weekly amount... provisions of the applicable State law for a week of total unemployment. In no event shall such amount be...

  18. Effects of an 18-week strength training program on low-handicap golfers' performance.

    PubMed

    Alvarez, María; Sedano, Silvia; Cuadrado, Gonzalo; Redondo, Juan Carlos

    2012-04-01

    The purpose of this study was to determine the effects of an 18-week strength training program on variables related to low-handicap golfers' performance. Ten right-handed male golfers, reporting a handicap of 5 or less, were randomly divided into two groups: the control group (CG) (N = 5, age: 23.9 ± 6.7 years) and the treatment group (TG) (N = 5, age: 24.2 ± 5.4 years). CG players followed the standard physical conditioning program for golf, which was partially modified for the TG. The TG participated in an 18-week strength training program divided into three parts: maximal strength training including weightlifting exercises (2 days a week for 6 weeks), explosive strength training with combined weights and plyometric exercises (2 days a week for 6 weeks), and golf-specific strength training, including swings with a weighted club and accelerated swings with an acceleration tubing system (3 days a week for 6 weeks). Body mass, body fat, muscle mass, jumping ability, isometric grip strength, maximal strength (RM), ball speed, and golf club mean acceleration were measured on five separate occasions. The TG demonstrated significant increases (p < 0.05) in maximal and explosive strength after 6 weeks of training and in driving performance after 12 weeks. These improvements remained unaltered during the 6-week golf-specific training period and even during a 5-week detraining period. It may be concluded that an 18-week strength training program can improve maximal and explosive strength and these increases can be transferred to driving performance; however, golfers need time to transfer the gains.

  19. Flutracking weekly online community survey of influenza-like illness annual report, 2015.

    PubMed

    Dalton, Craig B; Carlson, Sandra J; Durrheim, David N; Butler, Michelle T; Cheng, Allen C; Kelly, Heath A

    2016-12-24

    Flutracking is a national online community influenza-like illness (ILI) surveillance system that monitors weekly ILI activity and impact in the Australian community. This article reports on the 2015 findings from Flutracking. From 2014 to 2015 there was a 38.5% increase in participants to 27,824 completing at least 1 survey with a peak weekly response of 25,071 participants. The 2015 Flutracking national ILI weekly fever and cough percentages peaked in late August at 5.0% in the unvaccinated group, in the same week as the national counts of laboratory confirmed influenza peaked. A similar percentage of Flutracking participants took two or more days off from work or normal duties in 2015 (peak level 2.3%) compared with 2014 (peak level 2.5%) and the peak weekly percentage of participants seeking health advice was 1.6% in both 2014 and 2015. Flutracking fever and cough peaked in the same week as Influenza Complications Alert Network surveillance system influenza hospital admissions. The percentage of Flutracking participants aged 5 to 19 years with cough and fever in 2015 was the highest since 2011. The 2015 season was marked by a transition to predominantly influenza B strain circulation, which particularly affected younger age groups. However, for those aged 20 years and over, the 2015 national Flutracking influenza season was similar to 2014 in community ILI levels and impact.

  20. ONE WEEK VERSUS FOUR WEEK HEPARIN PROPHYLAXIS AFTER LAPAROSCOPIC SURGERY FOR COLORECTAL CANCER.

    ClinicalTrials.gov

    2012-04-28

    The Primary Study Objective is to Assess the Efficacy and; Safety of Extended 4-week Heparin Prophylaxis Compared to; Prophylaxis Given for 8±2 Days After Planned Laparoscopic; Surgery for Colorectal Cancer.; The Clinical Benefit Will be Evaluated as the Difference in; the Incidence of VTE or VTE-related Death Occurring Within 30 Days; From Surgery in the Two Study Groups.

  1. Weekly versus three weeks chemotherapy for advanced ovarian cancer: a meta-analysis

    PubMed Central

    Musella, Angela; Palaia, Innocenza; Monti, Marco; Musio, Daniela; Muzii, Ludovico; Tombolini, Vincenzo; Panici, Pierluigi Benedetti

    2016-01-01

    Aim Three weeks paclitaxel and carboplatin has been considered the standard of care for primary treatment of ovarian cancer (OC). Whether weekly therapy will further improve the clinical outcomes or not is still unclear. We conducted a meta-analysis to compare the two regimens. Method Articles were selected with a systematic approach, using PubMed databases. Trials concerning comparison between carboplatin plus weekly paclitaxel (dose-dense regimen) and carboplatin plus paclitaxel every 3 weeks were considered. Outcomes included overall survival (OS), progression free survival (PFS) and severe acute toxicity. Results Dose-dense regimen was associated with significant improvement of PFS compared with standard schedule, with HR of 0.73 (95% CI 0.61-0.88, p = 0.001). There was no difference in OS between treatment regimens (HR 0.95, 95% CI 0.77-1.16, p=0.06), as well as in term of severe acute toxicity. Conclusion Dose-dense regimen is superior to standard schedule in terms of PFS. Further studies are necessary to firmly confirm this evidence in advanced OC treatment. PMID:27509061

  2. Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS No. 1746-01-6) in Swiss-Webster Mice (Dermal Study).

    PubMed

    1982-02-01

    2,3,7,8-Tetrachlorodibenzo-p-dioxin occurs as a highly toxic impurity found in herbicides containing 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and 2,4,5-T- derivatives, as well as in other chemicals synthesized using 2,4,5-trichlorophenol. The herbicide 2,4,5-T has been marketed in the United States since 1948. Production increased sharply between 1960 and 1970 when a 1:1 mixture of 2,4,5-T and 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a defoliant in Vietnam under the names of "herbicide agent orange, herbicide orange, agent orange, and orange". During this 10-year period, about 106 million pounds of 2,4,5-T were sprayed. A carcinogenesis bioassay was conducted by applying an acetone suspension of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) to the clipped backs of 30 male and female Swiss-Webster mice 3 days per week for 99 or 104 weeks. Similar groups were pretreated with 1 application of 50 &mgr;g dimethylbenzanthracene (DMBA) in 0.1 ml acetone 1 week before TCDD administration began. Female mice received 0.005 &mgr;g TCDD per application, and the male mice received 0.001 &mgr;g TCDD. As vehicle controls, 45 mice of each sex received 0.1 ml acetone three times per week. Thirty animals of each sex were used as untreated controls. Throughout the bioassay, mean body weights of the male and female mice administered TCDD, or TCDD following DMBA, were essentially the same as those of the corresponding vehicle control group. Mean body weights of dosed and vehicle control groups of males were less thanthose of the untreated control group throughout the study; for the females, mean body weights were less than the untreated controls during the first 80 weeks. In female mice, the incidences of fibrosarcoma in the integumentary system in dosed groups with TCDD were significantly (P=0.007) higher than that in the corresponding controls (2/41, 5%; 8/27, 30%). An increase in the same tumor type, although not statistically significant (P=0.084), was also observed in

  3. One week's anti-Helicobacter pylori treatment for duodenal ulcer.

    PubMed Central

    Logan, R P; Gummett, P A; Misiewicz, J J; Karim, Q N; Walker, M M; Baron, J H

    1994-01-01

    This open study tested whether eradication of Helicobacter pylori (H pylori) heals duodenal ulcers as well as decreasing recurrence. H pylori was detected in patients with endoscopic duodenal ulcers by histology, CLO-test, culture, and 13C-urea breath test (13C-UBT). Tripotassium dicitrato bismuthate (120 mg) and amoxycillin (500 mg) each four times daily, were given for seven days, with 400 mg metronidazole five times a day on days 5-7. The 13C-UBT was repeated immediately after treatment and endoscopy repeated within 21 days. After treatment unhealed ulcers were reinspected one month later and healed ulcers followed up by 13C-UBT alone for 12 months. Of 45 patients, 44 were available for follow up. Mean pretreatment excess delta 13CO2 excretion was 25.6 per mil, which fell to 2.4 per mil immediately after finishing treatment, indicating clearance of H pylori in every patient. At the second endoscopy (median interval 20 days from start of treatment) 33 of 44 (75%) duodenal ulcers had healed. Ten of the remaining 11 duodenal ulcers were smaller and those 10 healed in the next two weeks with no further treatment. Two patients' ulcers that initially healed with clearance of H pylori recurred three weeks later (both had metronidazole resistant H pylori). H pylori was eradicated in 28 of 44 (64%) patients (13C-UBT negative for median follow up 10.2 months). Overall 41 of 43 (93%, 95% confidence intervals 81%-99%) duodenal ulcers were healed at one month. This study suggests that one week of anti-H pylori triple treatment is effective in healing duodenal ulcers. PMID:8307442

  4. Influence of weeks of circadian misalignment on leptin levels

    PubMed Central

    Nguyen, June; Wright, Kenneth P

    2010-01-01

    The neurobiology of circadian, wakefulness–sleep, and feeding systems interact to influence energy homeostasis. Sleep and circadian disruptions are reported to be associated with increased risk of diabetes and obesity, yet the roles of energy balance hormones in these associations are largely unknown. Therefore, in the current study we aimed to assess the influence of several weeks of circadian misalignment (sleep and wakefulness occurring at an inappropriate biological time) on the anorexigenic adipocyte hormone leptin. We utilized data from a previous study designed to assess physiological and cognitive consequences of changes in day length and light exposure as may occur during space flight, including exploration class space missions and exposure to the Martian Sol (day length). We hypothesized that circadian misalignment during an exploration class spaceflight simulation would reduce leptin levels. Following a three-week ~8 hours per night home sleep schedule, 14 healthy participants lived in the laboratory for more than one month. After baseline data collection, participants were scheduled to either 24.0 or 24.6 hours of wakefulness–sleep schedules for 25 days. Changes in the phase of the circadian melatonin rhythm, sleep, and leptin levels were assessed. Half of participants analyzed exhibited circadian misalignment with an average change in phase angle from baseline of ~4 hours and these participants showed reduced leptin levels, sleep latency, stage 2 and total sleep time (7.3 to 6.6 hours) and increased wakefulness after sleep onset (all P < 0.05). The control group remained synchronized and showed significant increases in sleep latency and leptin levels. Our findings indicate that weeks of circadian misalignment, such as that which occurs in circadian sleep disorders, alters leptin levels and therefore may have implications for appetite and energy balance. PMID:23524972

  5. Influence of weeks of circadian misalignment on leptin levels

    PubMed Central

    Nguyen, June; Wright, Kenneth P

    2010-01-01

    The neurobiology of circadian, wakefulness-sleep, and feeding systems interact to influence energy homeostasis. Sleep and circadian disruptions are reported to be associated with increased risk of diabetes and obesity, yet the roles of energy balance hormones in these associations are largely unknown. Therefore, in the current study we aimed to assess the influence of several weeks of circadian misalignment (sleep and wakefulness occurring at an inappropriate biological time) on the anorexigenic adipocyte hormone leptin. We utilized data from a previous study designed to assess physiological and cognitive consequences of changes in day length and light exposure as may occur during space fight, including exploration class space missions and exposure to the Martian Sol (day length). We hypothesized that circadian misalignment during an exploration class spaceflight simulation would reduce leptin levels. Following a three-week ~8 hours per night home sleep schedule, 14 healthy participants lived in the laboratory for more than one month. After baseline data collection, participants were scheduled to either 24.0 or 24.6 hours of wakefulness-sleep schedules for 25 days. Changes in the phase of the circadian melatonin rhythm, sleep, and leptin levels were assessed. Half of participants analyzed exhibited circadian misalignment with an average change in phase angle from baseline of ~4 hours and these participants showed reduced leptin levels, sleep latency, stage 2 and total sleep time (7.3 to 6.6 hours) and increased wakefulness after sleep onset (all P< 0.05). The control group remained synchronized and showed significant increases in sleep latency and leptin levels. Our findings indicate that weeks of circadian misalignment, such as that which occurs in circadian sleep disorders, alters leptin levels and therefore may have implications for appetite and energy balance. PMID:23616693

  6. Earth Science Week 2010 - Infrared Energy

    NASA Video Gallery

    This video explores what infrared energy is and how NASA detects it to study our Earth's systems more completely. Satellite measurements over time allow scientists to study seasonal changes in loca...

  7. Thirteen Week Oral Toxicity Study of WR238605 with a Thirteen Week Recovery Period in Rats. Volume 3 of 3

    DTIC Science & Technology

    1993-06-18

    STUDY ID: 098 SEX: FEMALE ABBR: HCV UNITS: fl. ANIMAL ID Week 2 Week 4 Week 8 Week 13 Week 16 Week 21 Week 27 GROUP: 0:0 821 822 mg...was usually focal and subpleural. It consisted of interstitial fibrosis , mononuclear cell infiltration, and sometimes hyperplasia of alveolar and...0 2 (20) 0 TRACHEA I Ex 10 10 THYROID GLAND * Ex 10 10 10 10 10 PARATHYROID GLAND Fibrosis # Ex 9 0 1 (11) 0 10 0 0 0 (0) 0 0

  8. Click chemistry: 1,2,3-triazoles as pharmacophores.

    PubMed

    Agalave, Sandip G; Maujan, Suleman R; Pore, Vandana S

    2011-10-04

    The copper(I)-catalyzed 1,2,3-triazole-forming reaction between azides and terminal alkynes has become the gold standard of 'click chemistry' due to its reliability, specificity, and biocompatibility. Applications of click chemistry are increasingly found in all aspects of drug discovery; they range from lead finding through combinatorial chemistry and target-templated in vitro chemistry, to proteomics and DNA research by using bioconjugation reactions. The triazole products are more than just passive linkers; they readily associate with biological targets, through hydrogen-bonding and dipole interactions. The present review will focus mainly on the recent literature for applications of this reaction in the field of medicinal chemistry, in particular on use of the 1,2,3-triazole moiety as pharmacophore.

  9. 1,2,3-Triazolium-Based Peptoid Oligomers.

    PubMed

    Aliouat, Hafida; Caumes, Cécile; Roy, Olivier; Zouikri, Mohamed; Taillefumier, Claude; Faure, Sophie

    2017-02-22

    The cis-directing effect of the 1,2,3-triazolium-type side chain was studied on dimeric peptoid models with various patterns: αα, αβ, βα and ββ. Low influences of the sequence and of the solvent were observed, the cis conformation of the amide carrying the triazolium ranging from 83 to 94% in proportion. The synthesis of peptoid homooligomers with four or eight pendant 1,2,3-triazolium side chains is described. α-, β- and α,β-peptoids carrying propargyl groups were subjected to CuAAC reaction using alkyl azides, and the resulting triazoles were quaternized providing well-defined multitriazolium platforms. The influence of the counteranion (PF6(-), BF4(-) or I(-)) on the conformation was also studied.

  10. Health Risk Assessment Approach for 2,3,7,8 ...

    EPA Pesticide Factsheets

    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most toxic and environmentally stable pollutants. In addition to various toxic effects, TCDD has been found to cause teratogenic, fetocidal, reproductive and carcinogenic effects in animals. In humans it adversely affects various organ systems and is probably carcinogenic as well. The report documents the methodologies utilized by the United States Environmental Protection Agency in its development of health risk assessment from exposure to TCDD. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is one of the most toxic and environmentally stable pollutants. In addition to various toxic effects, TCDD has been found to cause teratogenic, fetocidal, reproductive and carcinogenic effects in animals. In humans it adversely affects various organ systems and is probably carcinogenic as well.

  11. The thermodynamic properties of 2,3-benzothiophene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Steele, W.V.

    1991-01-01

    Upgrading of heavy fossil fuels is normally done by hydrotreating in the presence of catalysts at 5 to 15 MPa pressure of hydrogen and 575 to 700 K. The efficient use of expensive hydrogen in this process is essential to the economic viability of alternative fuel sources (heavy petroleum, tar sands, shale oil, and the products of the liquefaction of coal). 2,3-Benzothiophene is widely used as a model compound in catalyst-comparison and kinetic studies of the hydrodesulfurization (HDS) mechanism. To perform a thermodynamic analysis of the 2,3-benzothiophene/hydrogen reaction network at the process temperatures, Gibbs energies of reaction at those high temperatures are required for the molecules involved. Measurements leading to the calculation of the ideal-gas thermodynamic properties for 2,3-benzothiophene are reported. Experimental methods included adiabatic heat-capacity calorimetry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). The critical temperature and critical density were determined with the d.s.c., and the critical pressure was derived. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gas for selected temperatures between 260 K and 750 K. These values were derived by combining the reported measurements with values published previously for the enthalpy of combustion, the enthalpy of fusion, and the absolute entropy and enthalpy of the liquid at the triple-point temperature. Measured and derived quantities were compared with available literature values. 55 refs., 6 figs., 13 tabs.

  12. 2,3-Diphosphoglycerate and ATP dissociate erythrocyte membrane skeletons.

    PubMed

    Sheetz, M P; Casaly, J

    1980-10-25

    Since ATP and 2,3-diphosphoglycerate cause an increase in the lateral mobility of integral membrane proteins in the erythrocyte (Schindler, M., Koppel, D., and Sheetz, M. P. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 1457-1461), we have studied their effects on the membrane skeletal complex or shell (composed of spectrin, actin, and bands 4.1 (78,000 daltons) and 4.9 (50,000 daltons)) and its interaction with the erythrocyte membrane. Both phosphate compounds dissociated the delipidated shell complex, with half-maximal dissociation at 2.5 mM 2,3-diphosphoglycerate and 8 mM ATP, whereas equivalent concentrations of EDTA did not. Concomitant with complex dissociation, spectrin was solubilized but band 4.1 and actin remained in a complexed or polymeric form. When proteins which were involved in linking spectrin to the membrane were present on the shell, higher concentrations of the phosphate compounds still dissociated the complex but less spectrin was solubilized. Treatment of erythrocyte membranes with the same phosphate compounds caused membrane vesiculation but no proteins were solubilized. We suggest that ATP and 2,3-diphosphoglycerate, at concentrations which are normally present in erythrocytes, can weaken associations in the shell but will not dissociate the complex from membrane attachment sites.

  13. Weekly versus basic smoking cessation support in primary care: a randomised controlled trial

    PubMed Central

    Aveyard, Paul; Brown, Karen; Saunders, Cas; Alexander, Avril; Johnstone, Elaine; Munafò, Marcus R; Murphy, Mike

    2007-01-01

    Background There is insufficient and conflicting evidence about whether more intensive behavioural support is more effective than basic behavioural support for smoking cessation and whether primary care nurses can deliver effective behavioural support. Methods A randomised controlled trial was performed in 26 UK general practices. 925 smokers of ⩾10 cigarettes per day were randomly allocated to basic or weekly support. All participants were seen before quitting, telephoned around quit day, and seen 1 and 4 weeks after the initial appointment (basic support). Participants receiving weekly support had an additional telephone call at 10 days and 3 weeks after the initial appointment and an additional visit at 2 weeks to motivate adherence to nicotine replacement and renew quit attempts. 15 mg/16 h nicotine patches were given to all participants. The outcome was assessed by intention to treat analyses of the percentage confirmed sustained abstinence at 4, 12, 26 and 52 weeks after quit day. Results Of the 469 and 456 participants in the basic and weekly arms, the numbers (%) who quit and the percentage difference were 105 (22.4%) vs 102 (22.4%), 0.1% (95% CI −5.3% to 5.5%) at 4 weeks, 66 (14.1%) vs 52 (11.4%), −2.6% (95% CI −6.9% to 1.7%) at 12 weeks, 50 (10.7%) vs 40 (8.8%), −1.9% (95% CI −5.7% to 2.0%) at 26 weeks and 36 (7.7%) vs 30 (6.6%), −1.1% (95% CI −4.4% to 2.3%) at 52 weeks. Conclusions The absolute quit rates achieved are those expected from nicotine replacement alone, implying that neither basic nor weekly support were effective. Primary care smoking cessation treatment should provide pharmacotherapy with sufficient support only to ensure it is used appropriately, and those in need of support should be referred to specialists. PMID:17483139

  14. Comparison between once weekly, twice weekly, and daily oral iron therapy in Jordanian children suffering from iron deficiency anemia.

    PubMed

    Hawamdeh, Hasan M; Rawashdeh, Mohammad; Aughsteen, Adib Abdulahad

    2013-02-01

    The efficacy of daily versus twice weekly and once weekly oral iron therapy was analyzed to optimize a protocol for treatment of IDM among Jordanian children. One hundred and forty-eight children aged between 6 and 60 months with Hb estimate less than 11 gm/dl were screened. They were randomly divided into three regimens of oral iron therapy for a period of 12 weeks; a group was supplemented with a single weekly dose of iron; a second group received two doses weekly; and a third group had a daily dose of iron. Hb was assayed 3 and 12 weeks after therapy, while ferritin was assayed after 12 weeks of treatment. A significant rise in Hb concentration was observed which was most significant 12 weeks after treatment. Iron supplementation after 3 weeks was similar in all treated groups, and no significant difference in Hb concentration among the three groups was noticed. By the end of the third week, the anemia had respectively resolved by 18, 11.8 and 23.4% in the daily, twice weekly, and once weekly groups. On the other hand, the percentage of recovery of anemia respectively was 78, 90.2 and 74.5% at the end of 12 weeks of iron therapy. Hb recovery percentage was comparable in the three treated groups, and no significant difference was reported between them either at 3 or at 12 weeks of therapy. Ferritin levels in the daily and twice weekly treated groups were similar after 12 weeks of iron therapy and were significantly higher than the ferritin levels of weekly treated group. Although the anemia in the three treated groups was resolved after 3 and 12 weeks of oral iron therapy, we conclude that the regimen of two doses per week is the most effective in resolving anemia with less cost and fewer side effects.

  15. Efficacy of periodic centrifugation of primates during 4-week head-down tilt

    NASA Astrophysics Data System (ADS)

    Korolkov, V. I.; Kozlovskaya, I. B.; Kotovskaya, A. R.; Krotov, V. P.; Vil-Viliams, I. F.; Lobachik, V. I.

    2001-08-01

    Creation of artificial force of gravity (AFG) to counteract the negative consequences of microgravity in manned space missions of extended duration is one of the high-priority problems of space biology and medicine. However, there are a number of especial effects of AFG (namely, structural changes in muscles and bones, and some other system) which need implantation of electrodes and sensors and are possible only with animals. That is why it is of particular interest to make studies with monkeys whose reactions to changed gravity bear much resemblance with human (1). The purpose of the investigation was development of a protocol of periodic gravity loads as a countermeasure against the hypokinetic syndrome in Macaca mulatta. Two series of experiments were performed. In the series, animals were split into two groups of 6 species each who were motor restrained with the head end tilted downward at 5° (HDT) for 28 days. Monkeys of group-2 were periodically subjected to centrifugation (HDT+G). During the first series of experiments rotation was conducted in the +Gz direction at g-loads from 1.2 to 1.6 units for 30-40 minutes 4-5 times a week. In the second series, g-load was equal to 1.2 units and the animals were rotated 30 min. 2-3 time a week. The criterion of g-training protocol efficacy was a test +Gz run at 3 units for 30 s. during which functioning of the cardiovascular systems and its controls was evaluated. The test run was performed prior to and after HDT. Following HDT the animals of group HDT+G were more resistant to the test than their counterparts who had not been trained on the centrifuge. Data of the investigation imply that following HDT and HDT+G alike reduced the amount of total bodily fluids (by approximately 5%), the intracellular component (approximately 4%), and plasma volume (by 6-7%). Yet, there are radical differences between the groups in the levels of reduction in extracellular fluids (by 11% and 6.5%, respectively, P<0,05) and the

  16. GC-MS and GC-IRD analysis of 2-, 3- and 4-methylmethamphetamine and 2-, 3- and 4-methylamphetamine.

    PubMed

    Davis, Sean; Blakey, Karen; Rands-Trevor, Karen

    2012-07-10

    4-Methylmethamphetamine has been detected in samples submitted for analysis in several states throughout Australia. Six ring substituted methyl isomers of methamphetamine and amphetamine were synthesised and analysed. As the regioisomeric 2-, 3- and 4-methylmethamphetamine and 2-, 3- and 4-methylamphetamine have virtually identical mass spectra, the use of MS is an ineffective technique to discriminate between these closely related compounds. We set out to determine whether the regioisomers could be differentiated by a combination of GC-MS, acetyl derivatisation and GC-IRD. We demonstrate that the three isomers of methylmethamphetamine and methylamphetamine can be separated by GC, and a combination of acetyl derivatisation and vapour phase IR can identify the specific ring substituted compound.

  17. Changes in fibrinopeptide A peptides in the sera of rats chronically exposed to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

    PubMed

    Chen, Xi; Ma, Shi-wei; Ma, Xiao-ming; Xu, Yuan-jing; Tang, Nai-jun

    2012-03-01

    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a ubiquitously distributed endocrine disruptors. To investigate peptide changes in the sera of rats chronically exposed to TCDD and to explore the association of these changes with liver morphology, TCDD was administrated to male rats at doses of 140, 350, and 875 ng/kg/week for 29 weeks. Serum was collected and proteomic analysis was performed using automated Bruker Daltonics ClinProt with matrix-assisted laser desorption/ionization time-of-flight mass spectrometer. One peptide at 1740.89 was found to be significantly decreased and further identified with nano LC-MS/MS system. The MS BLAST homology search engine reported the peptide to be a partial sequence of fibrinopeptide A. Liver fatty degeneration and necrosis were assessed by hematoxylin and eosin staining. Liver fatty degeneration and necrosis were both found to be significantly increased after TCDD exposure. Levels of fibrinopeptide A were significantly correlated with liver fatty degeneration and necrosis.

  18. Application of enzymatic apple pomace hydrolysate to production of 2,3-butanediol by alkaliphilic Bacillus licheniformis NCIMB 8059.

    PubMed

    Białkowska, Aneta M; Gromek, Ewa; Krysiak, Joanna; Sikora, Barbara; Kalinowska, Halina; Jędrzejczak-Krzepkowska, Marzena; Kubik, Celina; Lang, Siegmund; Schütt, Fokko; Turkiewicz, Marianna

    2015-12-01

    2,3-Butanediol (2,3-BD) synthesis by a nonpathogenic bacterium Bacillus licheniformis NCIMB 8059 from enzymatic hydrolysate of depectinized apple pomace and its blend with glucose was studied. In shake flasks, the maximum diol concentration in fed-batch fermentations was 113 g/L (in 163 h, from the hydrolysate, feedings with glucose) while in batch processes it was around 27 g/L (in 32 h, from the hydrolysate and glucose blend). Fed-batch fermentations in the 0.75 and 30 L fermenters yielded 87.71 g/L 2,3-BD in 160 h, and 72.39 g/L 2,3-BD in 94 h, respectively (from the hydrolysate and glucose blend, feedings with glucose). The hydrolysate of apple pomace, which was for the first time used for microbial 2,3-BD production is not only a source of sugars but also essential minerals.

  19. Repeated administration of a mild acute toxic dose of di-n-butyltin dichloride at intervals of 3 weeks induces severe lesions in pancreas and liver of rats.

    PubMed

    Merkord, J; Weber, H; Kröning, G; Hennighausen, G

    2001-08-01

    Di-n-butyltin dichloride (DBTC) induced thymus atrophy, bile duct lesions, pancreatitis, and liver lesions in rats. Depending on dose [6 and 8 mg/kg intravenous (i.v.) DBTC] and time (1-24 weeks), the lesions in pancreas developed to a pancreatic fibrosis and the lesions in liver to liver cirrhosis. A single i.v. administration of 4 mg/kg DBTC induces a mild interstitial pancreatitis after 2-4 days followed by a restitutio ad integrum after 21-28 days. In the present study, the lesions of biliopancreatic duct, pancreas, and liver of rats after repeated administration of 4 mg/kg DBTC i.v. at intervals of 3 weeks have been investigated. The histopathological changes of pancreas and liver were examined by light microscopy 1,4, and 7 days and 2,3,4,6,9, and 12 weeks after administration of DBTC. Furthermore, pathobiochemical parameters of pancreatitis (amylase and lipase activity in serum), liver lesions (alkaline phosphatase activity and bilirubin in serum), and of fibrosis (hyaluronic acid in serum) were studied. Repeated administration of rats with DBTC (4 mg/kg i.v.) at intervals of 3 weeks induced an acute interstitial pancreatitis and after 9-12 weeks, a pancreatic fibrosis and liver lesions (intrahepatic bile duct hyperplasia, inflammation in periportal tract, and necrosis). In serum, elevated levels of alkaline phosphatase, bilirubin, and hyaluronic acid were found. This study demonstrates that the organotin compound induces toxic effects on pancreas and liver of rats by repeated administration of lower doses at long intervals. The risk of exposure to organotin at long intervals should be considered.

  20. 77 FR 31149 - National Small Business Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... 8826 of May 21, 2012 National Small Business Week, 2012 By the President of the United States of... America forward. During National Small Business Week, we celebrate the generations of entrepreneurs who...

  1. 75 FR 26871 - National Women's Health Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... Women's Health Week, 2010 Proclamation 8517--Mother's Day, 2010 Proclamation 8518--Peace Officers Memorial Day and Police Week, 2010 Executive Order 13541--Temporary Organization To Facilitate a Strategic... [[Page 26873

  2. Fewer Patients Die During Hospital Inspection Weeks: Study

    MedlinePlus

    ... 164254.html Fewer Patients Die During Hospital Inspection Weeks: Study Slight differences in death rates were possibly ... likely to die if they are treated during weeks that inspectors are checking on the staff, a ...

  3. Preemies Bombarded with Noise in First Weeks of Life

    MedlinePlus

    ... 163518.html Preemies Bombarded With Noise in First Weeks of Life But private rooms may not be ... healthy development." Very preterm babies often spend several weeks in neonatal intensive care units. Previous research by ...

  4. 7 CFR 59.204 - Mandatory weekly reporting for swine.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... slaughter week; and (2) The dollar value (in dollars per hundred pounds of carcass weight) paid to producers... noncarcass merit premium used by the packer during the current or the prior slaughter week. (c)...

  5. The Partial Aminolysis of (NPF2)3 or 4.

    DTIC Science & Technology

    1978-12-01

    as (NPC1 2)3 ~ , with primary or secondary amines or with alkoxides or aryl - oxides have b:en studied in detail.2 Under suitable reaction conditions...reactions between II and n—butylamine carried out in the presence of lithium bromide gave products that were virtually identical to those fo rmed in...g, 0.006 ml) in 10 ml of TN! was added to a solution of sodium phenoxide (prepared from 11.04 g (0.48 aol) sodium and 58.7 g (0.62 aol) of phenol in

  6. Diastereoselective synthesis of 2,3,4,5,6-pentafluoroheptanes.

    PubMed

    Farran, Daniel; Slawin, Alexandra M Z; Kirsch, Peer; O'Hagan, David

    2009-09-18

    A stereocontrolled synthesis of alkanes containing five contiguous fluorine atoms is presented. The compounds were prepared by sequential fluorination of diastereoisomeric alcohol-diepoxides. The chemistry involved epoxide ring-opening with HF.NEt(3) and deshydroxyfluorination reactions of free alcohols with Deoxo-Fluor. The fluorination reactions were all highly stereospecific, with all five fluorines being incorporated in three sequential steps. Three different diastereoisomers of the 2,3,4,5,6-pentafluoroheptyl motif were prepared as heptane-1,7-diol derivatives, a structural format amenable for incorporation of the vicinal pentafluoro scaffold into larger molecular architectures.

  7. Elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxine in goat milk.

    PubMed

    Arstila, A U; Reggiani, G; Sorvari, T E; Räisänen, S; Wipf, H K

    1981-11-01

    2,3,7,8-Tetrachlorodibenzo-p-dioxine (TCDD) 200 ng/day, was given orally to 7 goats for 2 months, followed by an elimination period of 1 month. Then a daily dose of 400 ng TCDD was given for 1 month to the same animals. Two animals were killed and the rest of the animals were observed for several months. The excretion of TCDD in milk was studied by glass capillary gas fragmentography, where the minimal detectable concentration was below 5 ppt. After the first feeding the concentration of TCDD in milk achieved a maximum of 20.8 +/- 6.6 ppt while a similar value of 19.3 +/- 6.6 ppt was observed after the second feeding. After this period, the concentration of TCDD decreased slowly with values, after 18 weeks, of 4, 2 +/-, 3 and 6 ppt. The concentration of TCDD in the liver in the two animals killed was 1039.0 and 898.0 ppt. There were no differences in clinical observations or blood and urine analyses when experimental animals were compared with controls.

  8. 77 FR 32877 - National Hurricane Preparedness Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ...#0;#0; ] Proclamation 8830 of May 25, 2012 National Hurricane Preparedness Week, 2012 By the... Preparedness Week, we rededicate ourselves to preventing loss of life and damage to property by raising... approach to emergency management begins with an informed public. This week, I encourage all...

  9. 77 FR 31147 - National Safe Boating Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... 8825 of May 21, 2012 National Safe Boating Week, 2012 By the President of the United States of America... Safe Boating Week, we renew our commitment to safe, responsible practices on our Nation's waterways. By... unsafe recreational boating. As we mark National Safe Boating Week, let us reflect on that...

  10. The 4-Day School Week. The Informed Educator Series

    ERIC Educational Resources Information Center

    Donis-Keller, Christine

    2010-01-01

    This "Informed Educator" examines the use of a 4-day school week as a way to reduce expenses while using limited resources most effectively. Discussion focuses on various models of 4-day week schedules, what to do during the fifth day, and how 4-day school weeks affect extracurricular activities. Detailed discussion of financial savings, student…

  11. 77 FR 65095 - National Forest Products Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... Documents#0;#0; ] Proclamation 8892 of October 19, 2012 National Forest Products Week, 2012 By the President... environments for us to explore. During National Forest Products Week, we celebrate sustainable uses of the... to our progress in the years ahead. This week, let us rededicate ourselves to managing our...

  12. 75 FR 48853 - National Health Center Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... Proclamation 8545--National Health Center Week, 2010 #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal...;The President ] Proclamation 8545 of August 5, 2010 National Health Center Week, 2010 By the President... preventive care. During National Health Center Week, we recognize the important work of community...

  13. 78 FR 35101 - Flag Day and National Flag Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-12

    ... Flag Week, 2013 By the President of the United States of America A Proclamation Each June, our Nation... responsibilities we share as citizens. This week, we celebrate that legacy, and we honor the brave men and women... President annually issue a proclamation designating the week in which June 14 occurs as ``National Flag...

  14. 77 FR 16645 - National Poison Prevention Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-21

    ... March 21, 2012 Part III The President Proclamation 8784--National Poison Prevention Week, 2012... Poison Prevention Week, 2012 By the President of the United States of America A Proclamation... thousands of lives every year. On the 50th anniversary of National Poison Prevention Week, I encourage...

  15. 77 FR 35807 - Flag Day and National Flag Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-15

    ...#0;#0; #0; ] Proclamation 8837 of June 11, 2012 Flag Day and National Flag Week, 2012 By the... against itself.'' This week, we mark nearly one century since that historic proclamation, and more than...), that the President annually issue a proclamation designating the week in which June 14 occurs...

  16. 76 FR 16521 - National Poison Prevention Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-23

    ... March 23, 2011 Part III The President Proclamation 8638--National Poison Prevention Week, 2011 #0; #0..., 2011 National Poison Prevention Week, 2011 By the President of the United States of America A... cases, these tragic incidents are preventable. During National Poison Prevention Week, I encourage...

  17. 78 FR 14625 - National Consumer Protection Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... March 6, 2013 Part II The President Proclamation 8937--National Consumer Protection Week, 2013... 8937 of March 1, 2013 National Consumer Protection Week, 2013 By the President of the United States of... Consumer Protection Week, we remember those lessons, and we recognize that our shared prosperity depends...

  18. 76 FR 20827 - National Crime Victims' Rights Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-13

    ... April 13, 2011 Part II The President Proclamation 8650--National Crime Victims' Rights Week, 2011 Proclamation 8651--Pan American Day and Pan American Week, 2011 Proclamation 8652--National Former Prisoner of... ] Proclamation 8650 of April 8, 2011 National Crime Victims' Rights Week, 2011 By the President of the...

  19. 75 FR 29391 - National Safe Boating Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-26

    ... 8524 of May 20, 2010 National Safe Boating Week, 2010 By the President of the United States of America... the water, let us recommit during National Safe Boating Week to practicing safe techniques so boaters... Safe Boating Week.'' NOW, THEREFORE, I, BARACK OBAMA, President of the United States of America,...

  20. 76 FR 59499 - National Hispanic-Serving Institutions Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-26

    ... Documents#0;#0; ] Proclamation 8718 of September 21, 2011 National Hispanic-Serving Institutions Week, 2011... National Hispanic-Serving Institutions (HSIs) Week, we renew our commitment to strengthening and expanding... education institutions serving Hispanic students to provide the best education possible. This week, as...

  1. 77 FR 25345 - National Crime Victims' Rights Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... April 27, 2012 Part V The President Proclamation 8804--National Crime Victims' Rights Week, 2012 #0; #0... Crime Victims' Rights Week, 2012 By the President of the United States of America A Proclamation For... they need, we know we must do more. This week, we rededicate ourselves to securing the full measure...

  2. 78 FR 17069 - National Poison Prevention Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-20

    ... Prevention Week, 2013 By the President of the United States of America A Proclamation For more than 50 years, Americans have marked National Poison Prevention Week by highlighting the steps we can take to protect ourselves and our loved ones from accidental poisoning. This week, we carry that tradition forward...

  3. 78 FR 49357 - National Health Center Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-14

    ... Center Week, 2013 By the President of the United States of America A Proclamation Community health... Health Center Week, we recognize health centers' significant contributions to keeping America healthy... week, we celebrate these valuable services and extend our thanks to the women and men who...

  4. 76 FR 49645 - National Health Center Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-10

    ... August 10, 2011 Part IV The President Proclamation 8698--National Health Center Week, 2011 #0; #0; #0... Health Center Week, 2011 By the President of the United States of America A Proclamation Across our..., advice, and critical services that keep them healthy. Throughout National Health Center Week, we...

  5. 75 FR 58281 - National Farm Safety and Health Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... Documents#0;#0; ] Proclamation 8565 of September 17, 2010 National Farm Safety and Health Week, 2010 By the... around the globe. As we celebrate National Farm Safety and Health Week, we recognize the tremendous... National Farm Safety and Health Week. I call upon the agencies, organizations, businesses, and...

  6. 77 FR 13959 - National Consumer Protection Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-08

    ... Protection Week, 2012 By the President of the United States of America A Proclamation Millions of Americans... practices pose serious risks to consumers and our economy alike. During National Consumer Protection Week... together to celebrate National Consumer Protection Week by highlighting the ways individuals and...

  7. 77 FR 58299 - National Hispanic-Serving Institutions Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... Documents#0;#0; ] Proclamation 8866 of September 14, 2012 National Hispanic-Serving Institutions Week, 2012... many Hispanic students and their families, and this week, we celebrate the critical role these colleges... Institutions Week. I call on public officials, educators, and all the people of the United States to...

  8. 76 FR 60351 - Minority Enterprise Development Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... September 28, 2011 Part IV The President Proclamation 8721--Minority Enterprise Development Week, 2011... Week, 2011 By the President of the United States of America A Proclamation Our Nation is guided by the... Development Week, we honor minority enterprises as vital to our economic success, and recommit to...

  9. 78 FR 62955 - National Character Counts Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... Counts Week, 2013 By the President of the United States of America A Proclamation As Americans, we are..., and that, above all, we are one people. During National Character Counts Week, we reflect on the ways..., but also the values that keep our country strong. This week, we reaffirm our commitment to helping...

  10. 75 FR 58283 - National Hispanic-Serving Institutions Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-23

    ... Documents#0;#0; ] Proclamation 8566 of September 17, 2010 National Hispanic-Serving Institutions Week, 2010... stage. This week, we celebrate the contributions of the more than 200 Hispanic-Serving Institutions in... proclaim September 19 through September 25, 2010, as National Hispanic-Serving Institutions Week. I...

  11. 76 FR 12817 - National Consumer Protection Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-09

    ... Protection Week, 2011 By the President of the United States of America A Proclamation Each day, families... communities. For more than a decade, National Consumer Protection Week has encouraged Americans to make better... from unfair and predatory practices. During National Consumer Protection Week, I encourage...

  12. 76 FR 57615 - National Health Information Technology Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-15

    ... September 15, 2011 Part IV The President Proclamation 8711--National Health Information Technology Week... September 12, 2011 National Health Information Technology Week, 2011 By the President of the United States... systems. During National Health Information Technology Week, we highlight the critical importance...

  13. 75 FR 2049 - National Influenza Vaccination Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-13

    ... Proclamation 8472--National Influenza Vaccination Week, 2010 #0; #0; #0; Presidential Documents #0; #0; #0;#0...;Title 3-- #0;The President ] Proclamation 8472 of January 8, 2010 National Influenza Vaccination Week... week presents a window of opportunity for us to prevent a possible third wave of H1N1 flu in the...

  14. 77 FR 47765 - National Health Center Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... Documents#0;#0; ] Proclamation 8847 of August 6, 2012 National Health Center Week, 2012 By the President of... emphasizing preventive care that helps people lead healthier lives. During National Health Center Week, we... our communities and our country. This week, we celebrate their many contributions to our public...

  15. 76 FR 27597 - National Women's Health Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... May 11, 2011 Part V The President Proclamation 8670--National Women's Health Week, 2011 Proclamation... ] Proclamation 8670 of May 6, 2011 National Women's Health Week, 2011 By the President of the United States of..., happy lives. During National Women's Health Week, we reaffirm our commitment to making women's health...

  16. 78 FR 62335 - National School Lunch Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-18

    ... Documents#0;#0; #0; ] Proclamation 9040 of October 11, 2013 National School Lunch Week, 2013 By the... school remains as important as ever. During National School Lunch Week, we recommit to the basic promise... healthier than its children.'' This week, as we look to a healthy future, we give our thanks to the...

  17. 75 FR 64615 - National Character Counts Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... Counts Week, 2010 By the President of the United States of America A Proclamation America's strength... National Character Counts Week, we reflect upon the values of equality, fairness, and compassion that lie... becomes a lifelong commitment. During National Character Counts Week, let us take this opportunity...

  18. 76 FR 65097 - National Forest Products Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... Documents#0;#0; ] Proclamation 8738 of October 14, 2011 National Forest Products Week, 2011 By the President... important part of our economy. During National Forest Products Week, we celebrate the value of our woodlands... forests, the Congress, by Public Law 86-753 (36 U.S.C. 123), as amended, has designated the week...

  19. 75 FR 64617 - National Forest Products Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... Documents#0;#0; ] Proclamation 8587 of October 15, 2010 National Forest Products Week, 2010 By the President... anniversary of National Forest Products Week, we recognize the enduring value of forests as sustainable... we write on. National Forest Products Week draws attention to these invaluable resources, and to...

  20. 77 FR 65091 - National Character Counts Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... October 24, 2012 Part III The President Proclamation 8891--National Character Counts Week, 2012 Proclamation 8892--National Forest Products Week, 2012 #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal...-- #0;The President ] Proclamation 8891 of October 19, 2012 National Character Counts Week, 2012 By...

  1. 75 FR 62451 - National Physician Assistants Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-12

    ... Documents#0;#0; ] Proclamation 8579 of October 6, 2010 National Physician Assistants Week, 2010 By the... shortages. During National Physician Assistants Week, we honor these dedicated medical professionals and.... As we recognize their countless contributions this week, we also pay tribute to the kind...

  2. 78 FR 72527 - Minority Enterprise Development Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-02

    ... December 2, 2013 Part VII The President Proclamation 9062--Minority Enterprise Development Week, 2013... President ] Proclamation 9062 of November 26, 2013 Minority Enterprise Development Week, 2013 By the... Development Week, we recognize the strength of our diverse workforce and the many ways minority...

  3. 78 FR 62957 - National Forest Products Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-10-23

    ... Documents#0;#0; ] Proclamation 9044 of October 18, 2013 National Forest Products Week, 2013 By the President... recreation for workers and families across our country. During National Forest Products Week, we celebrate... week, we recommit to collaborating across land ownership and landscapes, and we look to a future...

  4. 78 FR 24319 - National Crime Victims' Rights Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Documents#0;#0; ] Proclamation 8959 of April 19, 2013 National Crime Victims' Rights Week, 2013 By the...' Rights Week, we reaffirm our solemn obligation to ensure they get the services they need--from care and... fellow citizens and the basic values that unite us. Let us renew that common cause this week, and let...

  5. 75 FR 77517 - National Influenza Vaccination Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-10

    ... Proclamation 8615--National Influenza Vaccination Week, 2010 #0; #0; #0; Presidential Documents #0; #0; #0;#0...;Title 3-- #0;The President ] Proclamation 8615 of December 7, 2010 National Influenza Vaccination Week... complications take American lives each year. During National Influenza Vaccination Week, we remind all...

  6. 76 FR 25525 - National Charter Schools Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-05

    ...#0;#0; ] Proclamation 8664 of April 29, 2011 National Charter Schools Week, 2011 By the President of... administrators. During National Charter Schools Week, we recognize these institutions of learning and renew our... May 1 through May 7, 2011, as National Charter School Week. I commend our Nation's charter...

  7. 78 FR 26995 - National Charter Schools Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-08

    ... May 8, 2013 Part IV The President Proclamation 8975--National Charter Schools Week, 2013 Notice of May... Schools Week, 2013 By the President of the United States of America A Proclamation America's success in.... This week, we recognize charter schools that are advancing those goals, and we recommit to helping...

  8. 76 FR 35087 - Flag Day and National Flag Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-15

    ... June 15, 2011 Part II The President Proclamation 8689--Flag Day and National Flag Week, 2011 #0; #0; #0... and National Flag Week, 2011 By the President of the United States of America A Proclamation On June... Day, and during National Flag Week, we celebrate the powerful beacon of hope that our flag has...

  9. 78 FR 30727 - Emergency Medical Services Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-22

    ... Documents#0;#0; ] Proclamation 8982 of May 17, 2013 Emergency Medical Services Week, 2013 By the President... calm under pressure delivers comfort to neighbors in need. During Emergency Medical Services Week, we... society's well-being. In recent weeks, we have again seen the critical role EMS professionals play...

  10. 78 FR 32535 - National Hurricane Preparedness Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... May 30, 2013 Part II The President Proclamation 8986--National Hurricane Preparedness Week, 2013... 3-- #0;The President ] Proclamation 8986 of May 24, 2013 National Hurricane Preparedness Week, 2013... out for their neighbors and leaving nobody behind. This week, we reaffirm that it is never too...

  11. 75 FR 13215 - National Poison Prevention Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-19

    ... Prevention Week, 2010 By the President of the United States of America A Proclamation Since 1962, during National Poison Prevention Week we alert American families about the dangers of accidental poisonings and... campaigns like National Poison Prevention Week, childhood death rates from unintentional poisonings...

  12. 77 FR 58297 - National Farm Safety and Health Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... Documents#0;#0; ] Proclamation 8865 of September 14, 2012 National Farm Safety and Health Week, 2012 By the.... During National Farm Safety and Health Week, we celebrate agricultural workers' vital contributions and... American dream with their bare hands. This week, we honor their tireless efforts and rededicate...

  13. 75 FR 63689 - National School Lunch Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-15

    ... Proclamation 8583--National School Lunch Week, 2010 Proclamation 8584--Columbus Day, 2010 #0; #0; #0... School Lunch Week, 2010 By the President of the United States of America A Proclamation No child should... learning capacity, and instilled life-long healthy habits. This year, during National School Lunch Week,...

  14. 75 FR 24367 - National Charter Schools Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-05

    ...#0;#0; ] Proclamation 8510 of April 29, 2010 National Charter Schools Week, 2010 By the President of... driving reform throughout many school districts. During National Charter Schools Week, we recommit to... 8, 2010, as National Charter Schools Week. I commend our Nation's charter schools, teachers,...

  15. 77 FR 27553 - National Charter Schools Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-10

    ... May 10, 2012 Part III The President Proclamation 8815--National Charter Schools Week, 2012 #0; #0; #0... Schools Week, 2012 By the President of the United States of America A Proclamation As a Nation, we share a... work of educating our sons and daughters, and during National Charter Schools Week, we recognize...

  16. 77 FR 64019 - National School Lunch Week, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-17

    ... October 17, 2012 Part III The President Proclamation 8888--National School Lunch Week, 2012 #0; #0; #0... School Lunch Week, 2012 By The President Of The United States Of America A Proclamation Our children are.... During National School Lunch Week, we recognize all those whose dedicated work and care make...

  17. 78 FR 27032 - National Maritime Week Tugboat Races, Seattle, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-09

    ... SECURITY Coast Guard 33 CFR Part 100 National Maritime Week Tugboat Races, Seattle, WA AGENCY: Coast Guard... Local Regulation for the annual National Maritime Week Tugboat Races in Elliott Bay, WA from 12 p.m... Coast Guard will enforce the Special Local Regulation for the annual National Maritime Week...

  18. 76 FR 30495 - National Safe Boating Week, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-25

    ... 8680 of May 20, 2011 National Safe Boating Week, 2011 By the President of the United States of America... are enjoyable, but can sometimes pose dangers to watergoers. National Safe Boating Week is an... Boating Week, the United States Coast Guard partners with boating organizations to raise awareness on...

  19. Morbidity and Mortality Weekly Report. Volume 60, Number 15

    ERIC Educational Resources Information Center

    Moolenaar, Ronald L., Ed.

    2011-01-01

    The "Morbidity and Mortality Weekly Report" ("MMWR") Series is prepared by the Centers for Disease Control and Prevention (CDC). Data presented by the Notifiable Disease Data Team and 122 Cities Mortality Data Team in the weekly "MMWR" are provisional, based on weekly reports to CDC by state health departments. This…

  20. Morbidity and Mortality Weekly Report. Volume 61, Number 33

    ERIC Educational Resources Information Center

    Moolenaar, Ronald L., Ed.

    2012-01-01

    The "Morbidity and Mortality Weekly Report" ("MMWR") Series is prepared by the Centers for Disease Control and Prevention (CDC). Data presented by the Notifiable Disease Data Team and 122 Cities Mortality Data Team in the weekly "MMWR" are provisional, based on weekly reports to CDC by state health departments. This…

  1. Morbidity and Mortality Weekly Report. Volume 61, Number 13

    ERIC Educational Resources Information Center

    Moolenaar, Ronald L., Ed.

    2012-01-01

    The "Morbidity and Mortality Weekly Report" ("MMWR") Series is prepared by the Centers for Disease Control and Prevention (CDC). Data presented by the Notifiable Disease Data Team and 122 Cities Mortality Data Team in the weekly "MMWR" are provisional, based on weekly reports to CDC by state health departments. This…

  2. Morbidity and Mortality Weekly Report. Volume 60, Number 23

    ERIC Educational Resources Information Center

    Centers for Disease Control and Prevention, 2011

    2011-01-01

    The "Morbidity and Mortality Weekly Report" ("MMWR") Series is prepared by the Centers for Disease Control and Prevention (CDC). Data presented by the Notifiable Disease Data Team and 122 Cities Mortality Data Team in the weekly "MMWR" are provisional, based on weekly reports to CDC by state health departments. This issue of "Morbidity and…

  3. Morbidity and Mortality Weekly Report. Volume 61, Number 17

    ERIC Educational Resources Information Center

    Moolenaar, Ronald L., Ed.

    2012-01-01

    The "Morbidity and Mortality Weekly Report" ("MMWR") Series is prepared by the Centers for Disease Control and Prevention (CDC). Data presented by the Notifiable Disease Data Team and 122 Cities Mortality Data Team in the weekly "MMWR" are provisional, based on weekly reports to CDC by state health departments. This…

  4. 7 CFR 59.302 - Mandatory weekly reporting for lambs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... lambs purchased through a formula marketing arrangement and slaughtered during the prior slaughter week... 7 Agriculture 3 2011-01-01 2011-01-01 false Mandatory weekly reporting for lambs. 59.302 Section... (CONTINUED) LIVESTOCK MANDATORY REPORTING Lamb Reporting § 59.302 Mandatory weekly reporting for lambs....

  5. 7 CFR 59.302 - Mandatory weekly reporting for lambs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... lambs purchased through a formula marketing arrangement and slaughtered during the prior slaughter week... 7 Agriculture 3 2012-01-01 2012-01-01 false Mandatory weekly reporting for lambs. 59.302 Section... (CONTINUED) LIVESTOCK MANDATORY REPORTING Lamb Reporting § 59.302 Mandatory weekly reporting for lambs....

  6. 7 CFR 59.302 - Mandatory weekly reporting for lambs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... lambs purchased through a formula marketing arrangement and slaughtered during the prior slaughter week... 7 Agriculture 3 2014-01-01 2014-01-01 false Mandatory weekly reporting for lambs. 59.302 Section... (CONTINUED) LIVESTOCK MANDATORY REPORTING Lamb Reporting § 59.302 Mandatory weekly reporting for lambs....

  7. 7 CFR 59.302 - Mandatory weekly reporting for lambs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... lambs purchased through a formula marketing arrangement and slaughtered during the prior slaughter week... 7 Agriculture 3 2010-01-01 2010-01-01 false Mandatory weekly reporting for lambs. 59.302 Section... (CONTINUED) LIVESTOCK MANDATORY REPORTING Lamb Reporting § 59.302 Mandatory weekly reporting for lambs....

  8. 7 CFR 59.302 - Mandatory weekly reporting for lambs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... lambs purchased through a formula marketing arrangement and slaughtered during the prior slaughter week... 7 Agriculture 3 2013-01-01 2013-01-01 false Mandatory weekly reporting for lambs. 59.302 Section... (CONTINUED) LIVESTOCK MANDATORY REPORTING Lamb Reporting § 59.302 Mandatory weekly reporting for lambs....

  9. Morbidity and Mortality Weekly Report. Volume 61, Number 31

    ERIC Educational Resources Information Center

    Moolenaar, Ronald L., Ed.

    2012-01-01

    The "Morbidity and Mortality Weekly Report" ("MMWR") Series is prepared by the Centers for Disease Control and Prevention (CDC). Data presented by the Notifiable Disease Data Team and 122 Cities Mortality Data Team in the weekly "MMWR" are provisional, based on weekly reports to CDC by state health departments. This…

  10. Winter fuels report, week ending September 27, 1991. [Contains glossary

    SciTech Connect

    Not Available

    1991-10-03

    This report is intended to provide concise, timely information to the industry, the press, policymakers, consumers, analysts, and state and local governments on the following topics: distillate fuel oil net production, imports and stocks for all Petroleum Administration for Defense Districts (PADD) and product supplied on a US level; propane net production, imports and stocks for PADD's 1, 2, 3; natural gas supply and disposition and underground storage for the United States and consumption for all PADD's; residential and wholesale pricing data for propane and heating oil for those states participating in the joint Energy Information Administration (EIA)/State Heating Oil and Propane Program; crude oil and petroleum price comparisons for the United States and selected cities; and US total heating degree-days by city. 37 figs., 13 tabs.

  11. Metabolism, mitochondrial uptake and toxicity of 2', 3'-dideoxycytidine.

    PubMed Central

    Rossi, L; Serafini, S; Schiavano, G F; Casabianca, A; Vallanti, G; Chiarantini, L; Magnani, M

    1999-01-01

    2',3'-Dideoxycytidine (ddCyd) is a prescription anti-retroviral drug that causes mitochondrial toxicity and peripheral neuropathy. ddCyd is actively phosphorylated by cytosolic deoxycytidine kinase and nucleoside (di)phosphate kinase to the 5'-triphosphate derivative. However, 2',3'-dideoxycytidine 5'-diphosphocholine (ddCDP-choline) was also found in human cells incubated with ddCyd. In this paper we show that ddCDP-choline is produced from dideoxyCTP (ddCTP) and phosphocholine by phosphocholine cytidylyltransferase. dCTP and CTP appear to activate this synthesis in a concentration-dependent manner. Although ddCTP and ddCDP-choline can both enter the mitochondria, ddCDP-choline uptake is more efficient than ddCTP uptake. These data suggest that ddCDP- choline is the ddCyd metabolite that is probably responsible for mitochondrial toxicity. The uptake of ddCTP and ddCDP-choline by mitochondria is inhibited by 3.0 mM l-carnitine in the cell-free system investigated; when added to U937 cells grown in the presence of 0.25 microM ddCyd, 3.0 mM l-carnitine partially abrogated the mitochondrial toxicity of ddCyd. PMID:10585881

  12. ?`Caos en la Resonancia 2:3 con Urano?

    NASA Astrophysics Data System (ADS)

    Fernández, S.; Nicotra, M. A.

    The 2:3 resonace with Uranus and 3:2 with Neptune define limits in the semi -major axis interval, where some objects like 7066 Nessus (semi-major axis 24.456 au) has been observed. In this contribution, we describe the dynamics of a mass-less test particle near the critical value of the semi-major axis for each resonance. We analize the structure of the phase space in each case, using the restricted three-body planar approach, for different values of the Jacobi constant. Although this aproximation does not reflect the whole complexity of this region, it constitutes a good first solution, since there are not first or second order orbital resonances with the major planets. For the 2:3 resonance with Uranus, we find a smooth curve of quasi-periodical orbits surrounding the periodic orbit corresponding to the critical value of the semi-major axis. This region is also surrounded by chaotic orbits, probably due to the presence of other conmensurabilities of first or second order with Uranus. At the internal resonance 3:2 with Neptune, the structure of the section surfaces varies with the value of the C constant. In general, periodic orbits are found for the critical semi-major axis, but for other values of the Jacobi constant, which are obtained modifying the eccentricity of the particle orbit, the region is not closed anymore, so the test particle crosses the Neptune orbit, and escapes from this region.

  13. Conversion of 2,3-butanediol to butadiene

    DOEpatents

    Lilga, Michael A.; Frye, Jr, John G.; Lee, Suh-Jane; Albrecht, Karl O.

    2016-09-06

    A composition comprising 2,3-butanediol is dehydrated to methyl vinyl carbinol and/or 1,3-butadiene by exposure to a catalyst comprising (a) M.sub.xO.sub.y wherein M is a rare earth metal, a group IIIA metal, Zr, or a combination thereof, and x and y are based upon an oxidation state of M, or (b) M.sup.3.sub.a(PO.sub.4).sub.b where M.sup.3 is a group IA, a group IIA metal, a group IIIA metal, or a combination thereof, and a and b are based upon the oxidation state of M.sup.3. Embodiments of the catalyst comprising M.sub.xO.sub.y may further include M.sup.2, wherein M.sup.2 is a rare earth metal, a group IIA metal, Zr, Al, or a combination thereof. In some embodiments, 2,3-butanediol is dehydrated to methyl vinyl carbinol and/or 1,3-butadiene by a catalyst comprising M.sub.xO.sub.y, and the methyl vinyl carbinol is subsequently dehydrated to 1,3-butadiene by exposure to a solid acid catalyst.

  14. A 4-week Repeated dose Oral Toxicity Study of Mecasin in Sprague-Dawley Rats to Determine the Appropriate Doses for a 13-week, Repeated Toxicity Test

    PubMed Central

    Cha, Eunhye; Lee, Jongchul; Lee, Seongjin; Park, Manyong; Song, Inja; Son, Ilhong; Song, Bong-Keun; Kim, Dongwoung; Lee, Jongdeok

    2015-01-01

    Objectives: In this study, we investigated the 4-week repeated-dose oral toxicity of gami-jakyak gamcho buja decoction (Mecasin) to develop safe treatments. Methods: In order to investigate the 4-week oral toxicity of Mecasin, we administered Mecasin orally to rats. Sprague-Dawley (SD) rats were divided into four groups of five male and five female animals per group: group 1 being the control group and groups 2, 3, and 4 being the experimental groups. Doses of Mecasin of 500, 1,000, and 2,000 mg/kg of body weight were administered to the experimental groups, and a dose of normal saline solution of 10 mL/kg was administered to the control group. We examined the survival rate, weight, clinical signs, and gross findings for four weeks. This study was conducted under the approval of the Institutional Animal Ethics Committee. Results: No deaths occurred in any of the four groups. No significant changes in weights or food consumption between the control group and the experimental groups were observed. Serum biochemistry revealed that some groups showed significant decrease in inorganic phosphorus (IP) (P < 0.05). During necropsy on the rats, one abnormal macroscopic feature, a slight loss of fur, was observed in the mid dosage (1,000 mg/ kg) male group. No abnormalities were observed in any other rats. In histopathological findings, the tubular basophilia and cast of the kidney and extramedullary hematopoiesis of the spleen were found. However, those changes were minimal and had occurred naturally or sporadically. No other organ abnormalities were observed. Conclusion: During this 4-week, repeated, oral toxicity test of Mecasin in SD rats, no toxicity changes due to Mecasin were observed in any of the male or the female rats in the high dosage group. Thus, we suggest that the doses in a 13-week, repeated test should be 0, 500, 1,000, and 2,000 mg/kg respectively. PMID:26998389

  15. Cortical Reorganisation during a 30-Week Tinnitus Treatment Program

    PubMed Central

    McMahon, Catherine M.; Ibrahim, Ronny K.; Mathur, Ankit

    2016-01-01

    Subjective tinnitus is characterised by the conscious perception of a phantom sound. Previous studies have shown that individuals with chronic tinnitus have disrupted sound-evoked cortical tonotopic maps, time-shifted evoked auditory responses, and altered oscillatory cortical activity. The main objectives of this study were to: (i) compare sound-evoked brain responses and cortical tonotopic maps in individuals with bilateral tinnitus and those without tinnitus; and (ii) investigate whether changes in these sound-evoked responses occur with amelioration of the tinnitus percept during a 30-week tinnitus treatment program. Magnetoencephalography (MEG) recordings of 12 bilateral tinnitus participants and 10 control normal-hearing subjects reporting no tinnitus were recorded at baseline, using 500 Hz, 1000 Hz, 2000 Hz, and 4000 Hz tones presented monaurally at 70 dBSPL through insert tube phones. For the tinnitus participants, MEG recordings were obtained at 5-, 10-, 20- and 30- week time points during tinnitus treatment. Results for the 500 Hz and 1000 Hz sources (where hearing thresholds were within normal limits for all participants) showed that the tinnitus participants had a significantly larger and more anteriorly located source strengths when compared to the non-tinnitus participants. During the 30-week tinnitus treatment, the participants’ 500 Hz and 1000 Hz source strengths remained higher than the non-tinnitus participants; however, the source locations shifted towards the direction recorded from the non-tinnitus control group. Further, in the left hemisphere, there was a time-shifted association between the trajectory of change of the individual’s objective (source strength and anterior-posterior source location) and subjective measures (using tinnitus reaction questionnaire, TRQ). The differences in source strength between the two groups suggest that individuals with tinnitus have enhanced central gain which is not significantly influenced by the

  16. Efficacy of twice weekly iron supplementation in anemic adolescent girls.

    PubMed

    Shobha, S; Sharada, D

    2003-12-01

    Two hundred and forty four girls with different hemoglobin levels were selected, of which forty-one were non-anemic. The rest were graded as mildly, moderately or severely anemic and supplemented with 60 mg of iron daily or twice weekly for twelve weeks. There was no significant difference in the increase in hemoglobin levels between daily and twice weekly-supplemented subjects at the end of the study. Unpleasant side effects of supplementation were experienced by 57.8% of the daily supplemented subjects as against 5.9% of twice weekly-supplemented ones. Twice weekly supplementation could be recommended for overcoming anemia in adolescent girls.

  17. Using MODIS weekly evapotranspiration to monitor drought

    NASA Astrophysics Data System (ADS)

    Mu, Qiaozhen; Zhao, Maosheng; Running, Steven W.; Kimball, John S.; McDowell, Nathan G.

    2016-09-01

    The Stratospheric Observatory For Infrared Astronomy (SOFIA) is a 2.5-m telescope mounted inside of a Boeing 747SP. Planning and executing astronomical observations from an aircraft moving at 500 miles per hour has its own unique challenges and advantages. Scheduling and optimizing an entire year of science observations is a balancing act with target availability, instrument availability, and operational constraints. A SOFIA flight is well choreographed, and successfully executing observations on SOFIA requires many systems and people to work together- from the telescope assembly compensating for the continual vibration and movement of the plane in order to accurately point the telescope, the expertise of the telescope operators to prepare the telescope for use by the instrument operators, aircraft operations ensuring that the aircraft is ready for flight, and the mission systems control computers keeping track of all the data. In this paper we will discuss what it takes to plan a SOFIA flight, and what we do once we're in the air. We will share a typical science flight, as well as more challenging and unique observations that require SOFIA being in the right place at the right time.

  18. Developmental characteristics in sustained fetal tachycardia in 30 to 41 weeks of gestation.

    PubMed

    Shono, H; Muro, M; Shono, M; Ito, Y; Uchiyama, A; Sugimori, H

    1998-05-29

    The aim of the present study is to reveal gestational age-related changes in sustained foetal tachycardia (SFT). 24 h fetal heart rate (FHR) recordings were made on 102 normal pregnant women in 30-41 weeks of gestation. SFT was defined as an increase for 20 or more beats per minute from the FHR-baseline persisting for more than 20 min. In the results, SFTs in 38-39 weeks started during night-time (1900-0700) more frequently than during day-time (0700-1900) (P < 0.01, by chi-square test). The rate and duration were 0% and 0 min in 30-31 weeks of gestation, and increased to 85% and 114 min in 40-41 weeks, respectively. Two critical points were detected by a piecewise linear regression analysis: in the rate between 34-35 weeks and 36-37 weeks, and in the duration between 38-39 to 40-41 weeks. We conclude that gestational age-related changes in SFT depend on the developmental stages.

  19. Molecules in focus: indoleamine 2,3-dioxygenase.

    PubMed

    King, Nicholas J C; Thomas, Shane R

    2007-01-01

    Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. The local cellular depletion of l-tryptophan that results may enable the host to inhibit the growth of various infectious pathogens in vivo. However, over the past decade, it has become increasingly apparent that IDO also represents an important immune control enzyme. Thus, cells expressing IDO, seemingly paradoxically, are capable of suppressing local T cell responses to promote immune tolerance under various physiological and pathophysiological conditions of medical importance, including infectious diseases, foetal rejection, organ transplantation, neuropathology, inflammatory and auto-immune disorders and cancer. In this review, we briefly outline the biochemical properties of IDO, its known and hypothetical functions and the medical implications for inhibition or induction of IDO and/or its downstream catabolites in health and disease.

  20. Ligand Migration in Human Indoleamine-2,3 Dioxygenase

    PubMed Central

    Nienhaus, Karin; Nickel, Elena; Lu, Changyuan; Yeh, Syun-Ru; Nienhaus, G. Ulrich

    2015-01-01

    Summary Human indoleamine 2,3-dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L-tryptophan (L-Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L-Trp concentrations up to 50 µM; a further increase in the concentration of L-Trp causes a decrease in the activity. This substrate inhibition of hIDO is a result of the binding of a second L-Trp molecule in an inhibitory substrate binding site of the enzyme. The molecular details of the reaction and the inhibition are not yet known. In the following, we summarize the present knowledge about this heme enzyme. PMID:21445845

  1. Elastic Behavior of Y-1-2-3/SILVER Composites

    NASA Astrophysics Data System (ADS)

    Shekhar, S.; Reddy, R. Ravinder; Reddy, P. Venugopal; Mulay, V. N.

    A series of Y-1-2-3/Ag high Tc superconducting composites have been prepared using the sol-gel method by sintering at three different sintering temperatures, viz. 910°C, 945°C, and 975°C. After the usual characterization by XRD, electrical resistance, bulk density, and porosity measurements, the longitudinal (V1) and shear wave (Vs) velocities were measured by the pulse transmission technique. Using the experimental data, several elasticity parameters such as Young's modulus (E), rigidity modulus (G), etc. were evaluated. The variation of elastic constants with dopant concentration has been explained in terms of the binding forces between various atoms of the superconductor. A linear relationship between the superconducting transition temperature (Tc) and the Debye temperature (θD) has also been obtained.

  2. 1-Do-decyl-indoline-2,3-dione.

    PubMed

    Qachchachi, Fatima-Zahrae; Ouazzani Chahdi, Fouad; Misbahi, Houria; Bodensteiner, Michael; El Ammari, Lahcen

    2014-02-01

    The structure of the title compound, C20H29NO2, is isotypic to that of its homologue 1-octylindoline-2,3-dione. The indoline ring and the two carbonyl-group O atoms are approximately coplanar, the largest deviation from the mean plane being 0.0760 (10) Å. The mean plane through the fused-ring system is nearly perpendicular to the mean plane passing through the 1-dodecyl chain [dihedral angle = 77.69 (5)°]. All C atoms of the dodecyl group are in an anti-periplanar arrangement. In the crystal, mol-ecules are linked by C-H⋯O hydrogen bonds, forming a three-dimensional network.

  3. Metabolism of allylbenzene 2',3'-oxide and estragole 2',3'-oxide in the isolated perfused rat liver.

    PubMed

    Luo, G; Guenthner, T M

    1995-02-01

    The metabolism of allylbenzene 2',3'-oxide, estragole 2',3'-oxide, allylbenzene and estragole was studied in the isolated perfused rat liver. Formation of dihydrodiol and glutathione conjugate metabolites was detected for both epoxides and the presence of dihydrodiol metabolites after perfusion of allylbenzene or estragole indicated the formation of allylic epoxide intermediates in the intact liver. A comparison of elimination kinetics for parent compounds and epoxides indicated that epoxides were relatively rapidly detoxified and probably do not accumulate on formation in vivo. Acute toxicity of epoxides, measured as the release of alanine aminotransferase activity into the perfusate, or genetic toxicity, determined as covalent binding of radiolabeled epoxide to DNA, were not observed. It was concluded that both epoxide hydrolases and glutathione S-transferases can effectively detoxify the allylic epoxides derived from either allylbenzene or estragole and effectively prevent cellular or genetic toxicity of these reactive intermediates. Epoxide hydrolases appear to play the major role in the detoxication of these epoxides in vivo.

  4. Phlebotomy eliminates the maximal cardiac output response to six weeks of exercise training.

    PubMed

    Bonne, Thomas C; Doucende, Gregory; Flück, Daniela; Jacobs, Robert A; Nordsborg, Nikolai B; Robach, Paul; Walther, Guillaume; Lundby, Carsten

    2014-05-15

    With this study we tested the hypothesis that 6 wk of endurance training increases maximal cardiac output (Qmax) relatively more by elevating blood volume (BV) than by inducing structural and functional changes within the heart. Nine healthy but untrained volunteers (Vo2max 47 ± 5 ml·min(-1)·kg(-1)) underwent supervised training (60 min; 4 times weekly at 65% Vo2max for 6 wk), and Qmax was determined by inert gas rebreathing during cycle ergometer exercise before and after the training period. After the training period, blood volume (determined in duplicates by CO rebreathing) was reestablished to pretraining values by phlebotomy and Qmax was quantified again. Resting echography revealed no structural heart adaptations as a consequence of the training intervention. After the training period, plasma volume (PV), red blood cell volume (RBCV), and BV increased (P < 0.05) by 147 ± 168 (5 ± 5%), 235 ± 64 (10 ± 3%), and 382 ± 204 ml (7 ± 4%), respectively. Vo2max was augmented (P < 0.05) by 10 ± 7% after the training period and decreased (P < 0.05) by 8 ± 7% with phlebotomy. Concomitantly, Qmax was increased (P < 0.05) from 18.9 ± 2.1 to 20.4 ± 2.3 l/min (9 ± 6%) as a consequence of the training intervention, and after normalization of BV by phlebotomy Qmax returned to pretraining values (18.1 ± 2.5 l/min; 12 ± 5% reversal). Thus the exercise training-induced increase in BV is the main mechanism increasing Qmax after 6 wk of endurance training in previously untrained subjects.

  5. Effect of bisphosphonate initiation at week 2 versus week 12 on short-term functional recovery after femoral neck fracture: a randomized controlled trial.

    PubMed

    Unnanuntana, Aasis; Laohaprasitiporn, Panai; Jarusriwanna, Atthakorn

    2017-12-01

    The appropriate time to initiate bisphosphonate treatment after a fragility fracture has not yet been established. In this study, we found no significant differences in short-term functional recovery between femoral neck fracture patients who received bisphosphonate treatment at 2 versus 12 weeks after hemiarthroplasty.

  6. Efficient microwave assisted synthesis of novel 1,2,3-triazole-sucrose derivatives by cycloaddition reaction of sucrose azides and terminal alkynes.

    PubMed

    Potewar, Taterao M; Petrova, Krasimira T; Barros, M Teresa

    2013-09-20

    Novel 1-(1',2,3,3',4,4',6-hepta-O-acetyl-6'-deoxy-sucros-6'-yl)-4-substituted-1,2,3-triazoles were synthesized by microwave assisted copper catalyzed 1,3-dipolar cycloaddition of sucrose derived azides with terminal alkynes in excellent yields and in short reaction times. The compound 1',2,3,3',4,4',6-hepta-O-acetyl-6'-azido-6'-deoxy-sucrose was regioselectively synthesized from sucrose by improved procedure and used for the cycloadditions. By combining carbohydrate and 1,2,3-triazole structural motifs, a library of 1,2,3-triazole-sucrose conjugates have been obtained.

  7. Comparing the effects of 3 weeks of upper-body vibration training, vibration and stretching, and stretching alone on shoulder flexibility in college-aged men.

    PubMed

    Ferguson, Steven L; Kim, Eonho; Seo, Dong-Il; Bemben, Michael G

    2013-12-01

    This study compared the effects of 3 weeks of upper-body vibration training, vibration and stretching, and stretching alone on shoulder flexibility in college-aged men. Twenty-one men were randomly assigned to vibration-stretching (VS; n = 8), vibration only (VO; n = 6), or stretching only (SO; n = 7) groups that trained 3 times per week for 3 weeks. All 3 groups performed 9 total sets of 30-second stretches. The VS group performed four 30-second upper-body vibration exercises and five 30-second upper-body stretching exercises. The VO group performed nine 30-second upper-body vibration exercises. The SO group performed nine 30-second upper-body stretching exercises. Shoulder flexion (SF), shoulder extension (SE), and shoulder transverse extension (STE) were assessed by a Leighton Flexometer and back scratch tests bilaterally (BSR, BSL) were measured via tape measure. A 1-way analysis of variance (ANOVA) evaluated groups at baseline and a 2-way repeated-measures ANOVA evaluated the interventions over time. At baseline, there were no group differences in age, height, or weight. There was a significant (p < 0.01) time main effect for each flexibility outcome variable (SF: +6.1%, +3.9%, +3.4%; SE: +8.9%, +13.5%, +26.9%; STE: +12.8%, +8.7%, +24.3%; BSR: +4.4 cm, +3.4 cm, +3.1 cm; BSL: +3.6 cm, +2.3 cm, +6.1 cm) for SO, VO, and VS, respectively. Shoulder extension was the only variable that showed a significant (p < 0.05) interaction effect for group by time. In conclusion, vibration training, alone or combined with stretching, is a viable alternative to a standard stretching routine when attempting to increase shoulder flexibility. Adding vibration training to a flexibility regimen may improve the likelihood of regularly performing flexibility sessions because of increased variety.

  8. Modeling and forecasting of KLCI weekly return using WT-ANN integrated model

    NASA Astrophysics Data System (ADS)

    Liew, Wei-Thong; Liong, Choong-Yeun; Hussain, Saiful Izzuan; Isa, Zaidi

    2013-04-01

    The forecasting of weekly return is one of the most challenging tasks in investment since the time series are volatile and non-stationary. In this study, an integrated model of wavelet transform and artificial neural network, WT-ANN is studied for modeling and forecasting of KLCI weekly return. First, the WT is applied to decompose the weekly return time series in order to eliminate noise. Then, a mathematical model of the time series is constructed using the ANN. The performance of the suggested model will be evaluated by root mean squared error (RMSE), mean absolute error (MAE), mean absolute percentage error (MAPE). The result shows that the WT-ANN model can be considered as a feasible and powerful model for time series modeling and prediction.

  9. Final report on Weeks Island Monitoring Phase : 1999 through 2004.

    SciTech Connect

    Ehgartner, Brian L.; Munson, Darrell Eugene

    2005-05-01

    This Final Report on the Monitoring Phase of the former Weeks Island Strategic Petroleum Reserve crude oil storage facility details the results of five years of monitoring of various surface accessible quantities at the decommissioned facility. The Weeks Island mine was authorized by the State of Louisiana as a Strategic Petroleum Reserve oil storage facility from 1979 until decommissioning of the facility in 1999. Discovery of a sinkhole over the facility in 1992 with freshwater inflow to the facility threatened the integrity of the oil storage and led to the decision to remove the oil, fill the chambers with brine, and decommission the facility. Thereafter, a monitoring phase, by agreement between the Department of Energy and the State, addressed facility stability and environmental concerns. Monitoring of the surface ground water and the brine of the underground chambers from the East Fill Hole produced no evidence of hydrocarbon contamination, which suggests that any unrecovered oil remaining in the underground chambers has been contained. Ever diminishing progression of the initial major sinkhole, and a subsequent minor sinkhole, with time was verification of the response of sinkholes to filling of the facility with brine. Brine filling of the facility ostensively eliminates any further growth or new formation from freshwater inflow. Continued monitoring of sinkhole response, together with continued surface surveillance for environmental problems, confirmed the intended results of brine pressurization. Surface subsidence measurements over the mine continued throughout the monitoring phase. And finally, the outward flow of brine was monitored as a measure of the creep closure of the mine chambers. Results of each of these monitoring activities are presented, with their correlation toward assuring the stability and environmental security of the decommissioned facility. The results suggest that the decommissioning was successful and no contamination of the

  10. The effects of ten weeks of resistance and combined plyometric/sprint training with the Meridian Elyte athletic shoe on muscular performance in women.

    PubMed

    Ratamess, Nicholas A; Kraemer, William J; Volek, Jeff S; French, Duncan N; Rubin, Martyn R; Gómez, Ana L; Newton, Robert U; Maresh, Carl M

    2007-08-01

    The purpose of this investigation was to examine the combined effects of resistance and sprint/plyometric training with or without the Meridian Elyte athletic shoe on muscular performance in women. Fourteen resistance-trained women were randomly assigned to one of 2 training groups: (a) an athletic shoe (N = 6) (AS) group or (b) the Meridian Elyte (N = 8) (MS) group. Training was performed for 10 weeks and consisted of resistance training for 2 days per week and 2 days per week of sprint/plyometric training. Linear periodized resistance training consisted of 5 exercises per workout (4 lower body, 1 upper body) for 3 sets of 3-12 repetition maximum (RM). Sprint/plyometric training consisted of 5-7 exercises per workout (4-5 plyometric exercises, 40-yd and 60-yd sprints) for 3-6 sets with gradually increasing volume (8 weeks) followed by a 2-week taper phase. Assessments for 1RM squat and bench press, vertical jump, broad jump, sprint speed, and body composition were performed before and following the 10-week training period. Significant increases were observed in both AS and MS groups in 1RM squat (12.0 vs. 14.6 kg), bench press (6.8 vs. 7.4 kg), vertical jump height (3.3 vs. 2.3 cm), and broad jump (17.8 vs. 15.2 cm). Similar decreases in peak 20-, 40-, and 60-m sprint times were observed in both groups (20 m: 0.14 vs. 0.11 seconds; 40 m: 0.29 vs. 0.34 seconds; 60 m: 0.45 vs. 0.46 seconds in AS and MS groups, respectively). However, when sprint endurance (the difference between the fastest and slowest sprint trials) was analyzed, there was a significantly greater improvement at 60 m in the MS group. These results indicated that similar improvements in peak sprint speed and jumping ability were observed following 10 weeks of training with either shoe. However, high-intensity sprint endurance at 60 m increased to a greater extent during training with the Meridian Elyte athletic shoe.

  11. Toxicity and carcinogenicity of 2,3-dibromo-1-propanol in F344/N rats and B6C3F1 mice.

    PubMed

    Eustis, S L; Haseman, J K; Mackenzie, W F; Abdo, K M

    1995-06-01

    2,3-Dibromo-1-propanol is a metabolite of the flame retardant tris(2,3-dibromopropyl) phosphate, previously shown to be a mutagen and carcinogen in experimental animals. Toxicology and carcinogenesis studies of 2,3-dibromo-1-propanol were conducted by applying the chemical in 95% ethanol to the interscapular skin of male and female F344/N rats and B6C3F1 mice 5 days a week for 13 weeks in the prechronic study and 48-55 weeks (rats) or 36-42 weeks (mice) in the carcinogenicity study. In the 13-week study, 10 rats and 10 mice of each sex received doses of 0, 44, 88, 177, 375, or 750 mg/kg. Deaths associated with chemical application occurred only in the high-dose (750 mg/kg) male mice. Chemical-related lesions were seen in the kidney of male rats, liver of female rats, and liver and lung of both sexes of mice. Based on the toxicity observed in the 13-week study, 50 rats of each sex received doses of 0, 188, or 375 mg/kg and 50 mice of each sex received 0, 88, or 177 mg/kg in the carcinogenicity study. The planned 2-year study was terminated early because of reduced survival of rats related to chemical-induced neoplasia and because of the appearance of antibodies to lymphocytic choriomeningitis virus in sentinel mice. Nearly all dosed rats had malignant neoplasms at one or more sites, while only one control male and one control female had malignant neoplasms. In rats, neoplasms induced by 2,3-dibromo-1-propanol occurred in the skin, nasal mucosa, Zymbal's gland, oral mucosa, esophagus, forestomach, intestines, liver, kidney, mammary gland (females), clitoral gland (females), spleen (males), and mesothelium (males). In mice, chemical-induced neoplasms occurred in the skin, forestomach, liver (males), and lung (males).

  12. Glucose and 2,3-butanediol-paired syntheses in undivided flow reactors

    SciTech Connect

    Park, K.

    1985-01-01

    Paired synthesis, an energy-efficient electrochemical process, was applied to two biomass derived feedstocks. Sorbitol and calcium gluconate were produced by pairing electrochemical reduction of glucose with indirect electrogenerated bromine oxidation of glucose. The optimum electrode materials and operating conditions for the paired synthesis are: Raney nickel powder cathode, a packed bed anode of graphite chips, an initial glucose concentration of 1.6 M, a 0.4 M calcium bromide electrolyte, ca. pH 7, 60/sup 0/C, applied current of 25 mA per gram of cathode material, a solution velocity of 0.08 cm/sec, a six-minute residence time outside the reactor and parallel electrolyte solution and current flow. The 2,3-butanediol paired synthesis consisted of oxidation of acetoin by electrogenerated bromine at the anode followed by the electro-reduction of acetoin to 2-butanone at the cathode. The high boiling 2,3-butanediol is converted to the low boiling 2-butanone via the paired synthesis, which facilitates the recovery process. The optimum electrode materials and operating conditions for the 2,3-butanediol paired synthesis are: an amalgamated zinc cathode, a packed bed anode of graphite chips, 1 M 2,3-butanediol, 0.02 M acetoin, 1 M NaBr, ca. pH 7, 20/sup 0/C, 1.4 mA/cm/sup 2/ cathode current density, 1 mA/cm/sup 2/ anode current density, 0.04 cm/sec solution velocity, 4 minute residence time outside the reactor, and parallel electrolyte solution and current flow.

  13. Weekly Cycle of Lightning: Evidence of Storm Invigoration by Pollution

    NASA Technical Reports Server (NTRS)

    Bell, Thomas L.; Rosenfeld, Daniel; Kim, Kyu-Myong

    2009-01-01

    We have examined summertime 1998 2009 U.S. lightning data from the National Lightning Detection Network (NLDN) to look for weekly cycles in lightning activity. As was found by Bell et al. (2008) for rain over the southeast U.S., there is a significant weekly cycle in afternoon lightning activity that peaks in the middle of the week there. The weekly cycle appears to be reduced over population centers. Lightning activity peaks on weekends over waters near the SE U.S. The statistical significance of weekly cycles over the western half of the country is generally small. We found no evidence of a weekly cycle of synoptic-scale forcing that might explain these patterns. The lightning behavior is entirely consistent with the explanation suggested by Bell et al. (2008) for the cycles in rainfall and other atmospheric data from the SE U.S., that aerosols can cause storms to intensify in humid, convectively unstable environments.

  14. The effects of four weeks aerobic training on saliva cortisol and testosterone in young healthy persons

    PubMed Central

    Alghadir, Ahmad H.; Gabr, Sami A.; Aly, Farag A.

    2015-01-01

    [Purpose] The purpose of this study was to evaluate the effect of 4 weeks moderate aerobic exercise on outcome measures of saliva stress hormones and lactate levels in healthy adult volunteers. [Subjects and Methods] Sixteen healthy students with an age range of 15–25 years participated in this study. The participants performed an exercise test of moderate intensity for 4 weeks, three times per week. The exercise was treadmill walking. Saliva concentrations of cortisol, testosterone and lactate dehydrogenase (LDH) were measured before and after the 4 weeks of moderate aerobic training using immunoassay techniques. [Results] After 4 weeks of exercise, there were significant increases in cortisol, free testosterone levels, and LDH activity along with a significant decrease in the ratios between testosterone and cortisol levels. No significant correlations were found among the studied parameters in the resting stage, a result which supports the positive effect of exercise on stress hormones following 4 weeks of training. [Conclusion] The results suggest that four weeks exercise of moderate intensity significantly affects the salivary stress hormones of young healthy volunteers. The data support the importance of salivary stress hormones as potential biological markers especially for older ages. However, more research is required to validate these biological markers which determine the host response to physical activity. PMID:26311920

  15. CGH observes National Women’s Health Week

    Cancer.gov

    This week, the U.S. Department of Health and Human Services is observing the 17th annual National Women’s Health Week. The goal of the National Women's Health Week is to empower women to make their health a priority. In celebration, the NCI Center for Global Health held a seminar on the Knowledge Summaries for Comprehensive Breast Cancer Control: Pathways for Advanced Cancer Planning.

  16. Recent progress in printed 2/3D electronic devices

    NASA Astrophysics Data System (ADS)

    Klug, Andreas; Patter, Paul; Popovic, Karl; Blümel, Alexander; Sax, Stefan; Lenz, Martin; Glushko, Oleksandr; Cordill, Megan J.; List-Kratochvil, Emil J. W.

    2015-09-01

    New, energy-saving, efficient and cost-effective processing technologies such as 2D and 3D inkjet printing (IJP) for the production and integration of intelligent components will be opening up very interesting possibilities for industrial applications of molecular materials in the near future. Beyond the use of home and office based printers, "inkjet printing technology" allows for the additive structured deposition of photonic and electronic materials on a wide variety of substrates such as textiles, plastics, wood, stone, tiles or cardboard. Great interest also exists in applying IJP in industrial manufacturing such as the manufacturing of PCBs, of solar cells, printed organic electronics and medical products. In all these cases inkjet printing is a flexible (digital), additive, selective and cost-efficient material deposition method. Due to these advantages, there is the prospect that currently used standard patterning processes can be replaced through this innovative material deposition technique. A main issue in this research area is the formulation of novel functional inks or the adaptation of commercially available inks for specific industrial applications and/or processes. In this contribution we report on the design, realization and characterization of novel active and passive inkjet printed electronic devices including circuitry and sensors based on metal nanoparticle ink formulations and the heterogeneous integration into 2/3D printed demonstrators. The main emphasis of this paper will be on how to convert scientific inkjet knowledge into industrially relevant processes and applications.

  17. The 2.3-Angstrom Structure of Porcine Circovirus 2

    SciTech Connect

    Khayat, Reza; Brunn, Nicholas; Speir, Jeffrey A.; Hardham, John M.; Ankenbauer, Robert G.; Schneemann, Anette; Johnson, John E.

    2012-10-25

    Porcine circovirus 2 (PCV2) is a T = 1 nonenveloped icosahedral virus that has had severe impact on the swine industry. Here we report the crystal structure of an N-terminally truncated PCV2 virus-like particle at 2.3-{angstrom} resolution, and the cryo-electron microscopy (cryo-EM) image reconstruction of a full-length PCV2 virus-like particle at 9.6-{angstrom} resolution. This is the first atomic structure of a circovirus. The crystal structure revealed that the capsid protein fold is a canonical viral jelly roll. The loops connecting the strands of the jelly roll define the limited features of the surface. Sulfate ions interacting with the surface and electrostatic potential calculations strongly suggest a heparan sulfate binding site that allows PCV2 to gain entry into the cell. The crystal structure also allowed previously determined epitopes of the capsid to be visualized. The cryo-EM image reconstruction showed that the location of the N terminus, absent in the crystal structure, is inside the capsid. As the N terminus was previously shown to be antigenic, it may externalize through viral 'breathing'.

  18. A HARPS view on K2-3

    NASA Astrophysics Data System (ADS)

    Almenara, J. M.; Astudillo-Defru, N.; Bonfils, X.; Forveille, T.; Santerne, A.; Albrecht, S.; Barros, S. C. C.; Bouchy, F.; Delfosse, X.; Demangeon, O.; Diaz, R. F.; Hébrard, G.; Mayor, M.; Neves, V.; Rojo, P.; Santos, N. C.; Wünsche, A.

    2015-09-01

    K2 space observations recently found that three super-Earths transit the nearby M dwarf K2-3. The apparent brightness and the small physical radius of their host star rank these planets amongst the most favourable for follow-up characterisations. The outer planet orbits close to the inner edge of the habitable zone and might become one of the first exoplanets searched for biomarkers using transmission spectroscopy. We used the HARPS velocimeter to measure the mass of the planets. The mass of planet b is 8.4 ± 2.1 M⊕, while our determination of those planets c and d are affected by the stellar activity. With a density of 4.32+2.0-0.76 g cm-3, planet b is probably mostly rocky, but it could contain up to 50% water. Based on observations made with the HARPS instrument on the ESO 3.6 m telescope under the program ID 191-C0873 at Cerro La Silla (Chile).Appendix A is available in electronic form at http://www.aanda.org

  19. Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase

    SciTech Connect

    Pantouris, Georgios; Mowat, Christopher G.

    2014-01-03

    Highlights: •∼2800 National Cancer Institute USA compounds have been screened as potential inhibitors of TDO and/or IDO. •Seven compounds with anti-tumour properties have been identified as potent inhibitors. •NSC 36398 (taxifolin, dihydroquercetin) is selective for TDO with a K{sub i} of 16 M. •This may help further our understanding of the role of TDO in cancer. -- Abstract: The involvement of tryptophan 2,3-dioxygenase (TDO) in cancer biology has recently been described, with the enzyme playing an immunomodulatory role, suppressing antitumour immune responses and promoting tumour cell survival and proliferation. This finding reinforces the need for specific inhibitors of TDO that may potentially be developed for therapeutic use. In this work we have screened ∼2800 compounds from the library of the National Cancer Institute USA and identified seven potent inhibitors of TDO with inhibition constants in the nanomolar or low micromolar range. All seven have antitumour properties, killing various cancer cell lines. For comparison, the inhibition potencies of these compounds were tested against IDO and their inhibition constants are reported. Interestingly, this work reveals that NSC 36398 (dihydroquercetin, taxifolin), with an in vitro inhibition constant of ∼16 μM, is the first TDO-selective inhibitor reported.

  20. Announcement: National Public Health Week - April 3-9, 2017.

    PubMed

    2017-03-31

    CDC joins the American Public Health Association (APHA) in celebration of National Public Health Week, April 3-9, 2017. Since 1995, APHA has led the observance of National Public Health Week during the first full week of April. The week recognizes the impact of public health on the health of the nation. The 2017 observance focuses on making the United States the Healthiest Nation in One Generation by 2030 by spotlighting the importance of prevention, employing successful strategies for collaboration, and promoting the critical role of a strong public health system.

  1. Time course of disassociation of bone formation signals with bone mass and bone strength in sclerostin antibody treated ovariectomized rats.

    PubMed

    Ma, Yanfei L; Hamang, Matthew; Lucchesi, Jonathan; Bivi, Nicoletta; Zeng, Qianqiang; Adrian, Mary D; Raines, Sarah E; Li, Jiliang; Kuhstoss, Stuart A; Obungu, Victor; Bryant, Henry U; Krishnan, Venkatesh

    2017-04-01

    Sclerostin antibodies increase bone mass by stimulating bone formation. However, human and animal studies show that bone formation increases transiently and returns to pre-treatment level despite ongoing antibody treatment. To understand its mechanism of action, we studied the time course of bone formation, correlating the rate and extent of accrual of bone mass and strength after sclerostin antibody treatment. Ovariectomized (OVX) rats were treated with a sclerostin-antibody (Scle-ab) at 20mg/kg sc once weekly and sacrificed at baseline and 2, 3, 4, 6, and 8weeks post-treatment. In Scle-ab treated rats, serum PINP and OCN rapidly increased at week 1, peaked around week 3, and returned to OVX control levels by week 6. Transcript analyses from the distal femur revealed an early increase in bone formation followed by a sustained decrease in bone resorption genes. Lumbar vertebral (LV) osteoblast surface increased 88% by week 2, and bone formation rate (BFR/BS) increased 138% by week 4. Both parameters were below OVX control by week 8. Bone formation was primarily a result of modeling based formation. Endocortical and periosteal BFR/BS peaked around week 4 at 313% and 585% of OVX control, respectively. BFR/BS then declined but remained higher than OVX control on both surfaces through week 8. Histomorphometric analyses showed LV-BV/TV did not further increase after week 4, while BMD continued to increase at LV, mid femur (MF), and femoral neck (FN) through week 8. Biomechanical tests showed a similar improvement in bone strength through 8weeks in MF and FN, but bone strength plateaued between weeks 6 and 8 for LV. Our data suggest that bone formation with Scle-ab treatment is rapid and modeling formation dominated in OVX rats. Although transient, the bone formation response persists longer in cortical than trabecular bone.

  2. Graduate student voice use and vocal efficiency in an opera rehearsal week: a case study.

    PubMed

    Schloneger, Matthew J

    2011-11-01

    The purpose of this case study was to document graduate voice students' (N=2) voice use before, during, and after an intense week of opera rehearsals through (1) acquired Ambulatory Phonation Monitor (APM) data, (2) daily surveys, (3) participant activity logs, (4) three administrations of the Singing Voice Handicap Index (SVHI), and (5) pre- and post-stroboscopic laryngeal examinations. Two female graduate students, both of whom were cast in a university production of Stravinsky's The Rake's Progress (stage names Anne and Baba) and both of whom served as graduate teaching assistants in voice, wore APMs during waking hours for 9 days, including two pretest baseline days, a 5-day intensive rehearsal week just before the opera production week, and 2 baseline days after opera performances were completed. Mean phonation time dose percentages (Dt) and daily distance dose averages (Dd) were similar between the pre- and posttest periods and the intensive week. Disaggregation of acquired data by four types of activities (opera rehearsals, personal practice time, voice teaching time, and nonrehearsal or teaching time) indicated that the highest mean Dts and Dds were acquired during personal practice time and voice teaching time. Daily surveys and SVHI data as well as the pre- and post-stroboscopies indicated no notable changes occurring in vocal health. Results indicated that these singers were conscious about their voice use during periods of extensive performance demands. However, high vocal doses during voice teaching times suggest that these individuals might benefit from teacher voice care education.

  3. A comparison of fatigue and energy levels at 6 weeks and 14 to 19 months postpartum.

    PubMed

    Troy, N W

    1999-05-01

    It has been assumed that women recover from pregnancy and childbirth within 6 weeks. Recent research shows that women's fatigue levels are the same, or higher, at 6 weeks postpartum as at the time of delivery. This study determined the differences in primiparous women's fatigue and energy levels at 6 weeks and 14 to 19 months postpartum. Determinations of how some contributing factors and outcomes of postpartum fatigue relate to each other and to fatigue and energy at 14 to 19 months postpartum were also made. Analyses revealed that women are more fatigued and less energetic at 14 to 19 months than they were at 6 weeks postpartum. Quality of sleep did not correlate with fatigue or energy. At 14 to 19 months postpartum return to full functional status is almost complete, with household and infant care responsibilities being most complete. The women were experiencing mild life crises of various sorts, were somewhat depressed, and were gratified in the mothering role.

  4. Knowing which day of the week it is: temporal structure and dynamics of memory.

    PubMed

    Carreras, Ophélie; Lemercier, Céline; Valax, Marie-Françoise

    2008-06-01

    The complementary role of static and dynamic information used when one needs to be located in time was studied. Static information refers to temporal knowledge about days of the week, and dynamic information reflects a sense of time, taking into account the present, the near past, and the future. Each day of an actual 7-day wk., 699 women and 620 men were asked to provide a "right" or "wrong" response to a statement such as "Today is X," where X was the name of one of the seven days of the week. Analysis suggested use of a structured temporal representation of the week: the weekend, a landmark, had an anchoring role. Also the dynamics of the content of working memory were indicated. The active "temporal window" participants hold in mind seems directed more towards the future than the past. Results are discussed within the more general context of time management.

  5. Intact connecting filaments change length in 2.3-nm quanta.

    PubMed

    Blyakhman, F; Tourovskaya, A; Pollack, G H

    2000-01-01

    In isolated titin molecules, length changes may occur in discrete steps (Tskhovrebova et al., 1997; Rief et al., 1997). The extent to which such steps are preserved in the intact muscle-filament lattice has remained unclear. We carried out experiments on single isolated insect-flight-muscle myofibrils in which thin filaments had been functionally removed either by stretch beyond overlap or by a "rigor-stretch" protocol, leaving the connecting (titin) filaments as the sole length-absorbing agent. The myofibril was released or stretched by a motor in ramp-like fashion. The time course of length change in the single sarcomere was stepwise. The same was true for half-sarcomere lengths. The presence of steps at the sarcomere level implies that parallel filaments step synchronously, with high cooperativity. Step sizes showed a consistent distribution: The smallest size was approximately 2.3 nm, and others were integer multiples of that value. Similar results were found for stretch and release. To our knowledge, the approximately 2.3-nm step quantum is the smallest consistent biomechanical event ever demonstrated. This quantum is an order of magnitude smaller than anticipated from the folding/unfolding of a complete Ig- or fibronectin-like domain, and may imply that folding occurs in sub-domain increments. The 2.3-nm incremental length change corresponds to a single turn of the domains' beta sheet.

  6. Production of 2,3-butanediol from acid hydrolysates of Jatropha hulls with Klebsiella oxytoca.

    PubMed

    Jiang, Li-Qun; Fang, Zhen; Guo, Feng; Yang, Lin-bin

    2012-03-01

    Jatropha hulls were successfully for the first time used as raw materials for the production of 2,3-butanediol via dilute sulfuric acid hydrolysis and fermentation with Klebsiella oxytoca. Two-step hydrolysis was used to effectively hydrolyze the hulls at 150°C after pretreatment. In the first-step, hemicellulose was hydrolyzed under mild conditions (0.5h, 1.5% acid) to avoid secondary decomposition. The remained cellulose was further hydrolyzed in the second-step under severer conditions (1h, 4% acid). After hydrolysis, total hydrolysis yield was 64%, which was much higher than that (37%) from the first-step. Maximum yields of 2,3-butanediol and acetoin in flask experiments were 35.6% and 41.4% from the hydrolysates of the first- and second-step hydrolysis, equivalent to 71.2% and 82.8% of the theoretical values, respectively. Similar yields were obtained in a controlled bioreactor but with higher productivities. Jatropha hulls are attractive raw materials for the production of 2,3-butanediol with high yield.

  7. THE 6-MINUTE WALK TEST AND OTHER ENDPOINTS IN DUCHENNE MUSCULAR DYSTROPHY: LONGITUDINAL NATURAL HISTORY OBSERVATIONS OVER 48 WEEKS FROM A MULTICENTER STUDY

    PubMed Central

    Mcdonald, Craig M; Henricson, Erik K; Abresch, R Ted; Florence, Julaine M; Eagle, Michelle; Gappmaier, Eduard; Glanzman, Allan M; Spiegel, Robert; Barth, Jay; Elfring, Gary; Reha, Allen; Peltz, Stuart

    2013-01-01

    Introduction: Duchenne muscular dystrophy (DMD) subjects ≥5 years with nonsense mutations were followed for 48 weeks in a multicenter, randomized, double-blind, placebo-controlled trial of ataluren. Placebo arm data (N = 57) provided insight into the natural history of the 6-minute walk test (6MWT) and other endpoints. Methods: Evaluations performed every 6 weeks included the 6-minute walk distance (6MWD), timed function tests (TFTs), and quantitative strength using hand-held myometry. Results: Baseline age (≥7 years), 6MWD, and selected TFT performance are strong predictors of decline in ambulation (Δ6MWD) and time to 10% worsening in 6MWD. A baseline 6MWD of <350 meters was associated with greater functional decline, and loss of ambulation was only seen in those with baseline 6MWD <325 meters. Only 1 of 42 (2.3%) subjects able to stand from supine lost ambulation. Conclusion: Findings confirm the clinical meaningfulness of the 6MWD as the most accepted primary clinical endpoint in ambulatory DMD trials. PMID:23681930

  8. Gene expression profiling of kidneys from Sprague-Dawley rats following 12-week inhalation exposure to silver nanoparticles.

    PubMed

    Dong, Mi Sook; Choi, Ji-Yoon; Sung, Jae Hyuck; Kim, Jin Sik; Song, Kyung Seuk; Ryu, Hyun Ryol; Lee, Ji Hyun; Bang, In Seok; An, Kangho; Park, Hyun Min; Song, Nam Woong; Yu, Il Je

    2013-07-01

    The specific properties of silver nanoparticles (AgNPs), such as antimicrobial activity and electrical conductivity, allow them to be used in many fields. However, their expanding application is also raising health, environmental and safety concerns. Previous in vivo AgNP toxicity studies have indicated a gender-different accumulation of silver in the kidneys, with 2-3 times more silver in female kidneys compared to male kidneys. However, no other studies have further addressed this gender difference. Accordingly, the current study investigated the gender-dependent effect of AgNPs on the kidney gene level based on toxicogenomic studies of kidneys obtained from rats exposed to AgNPs via inhalation for 12 weeks. When compared with the fresh air control, the silver nanoparticle-exposed kidneys included 104 genes with a more than 1.3-fold expression increase. For the male rat kidneys exposed to a low or high dose of silver nanoparticles, 96 genes exhibited expression changes, where six genes changed with both the low and high dose; four increased and two decreased. Meanwhile, for the female rat kidneys exposed to a low or high dose of silver nanoparticles, 66 genes exhibited expression changes, where 11 genes changed with both the low and high dose; nine increased and two decreased. Gender-dependent gene expression changes of more than 2-fold were linked to 163 genes, with 79 genes in the male kidneys and 84 genes in the female kidneys, plus gender-dependent gene expression changes of more than 5-fold were linked to 21 genes. However, no genes involved in apoptosis or the cell cycle were activated by the 12-week silver nanoparticle inhalation exposure. Overall, the male rat kidneys showed a higher expression of genes involved in xenobiotic metabolism, while the female rat kidneys showed a higher expression of genes involved in extracellular signaling.

  9. Astronomy On-Line Programme Enters "hot Week"

    NASA Astrophysics Data System (ADS)

    1996-11-01

    World's Biggest Astronomy WWW-Event Attracts Thousands of Students The Astronomy On-line Programme (See ESO Press Release 09/96 of 18 June 1996) began officially on 1 October and is now about to enter its most intense phase, known as the Hot Week . On 18 - 22 November, an estimated 4000 astronomy-interested, mostly young people in Europe and on four other continents will get together during five days in what - not unexpected - has become the world's biggest astronomy event ever organised on the World Wide Web. This carefully structured Programme is carried out in collaboration between the European Association for Astronomy Education (EAAE), the European Southern Observatory and the European Commission, under the auspices of the Fourth European Week for Scientific and Technological Culture. The Programme has already had a most visible impact on the school education of natural sciences in various countries; for instance, the Internet-connection of schools has been advanced in some, in order to allow groups to participate. There have been numerous contacts among the groups across the borders and there are clear signs that many Astronomy On-line participants have progressed to use the impressive possibilities of the Web in an efficient and structured way. There has been a lively media interest in Astronomy On-line all over Europe and it is expected to increase during the next week. The current status of Astronomy On-line It is obvious that the pilot function of the Astronomy On-line Programme in the use of the Web has been very effective and that the associated dissemination of astronomical knowledge has been successful. At this time, more than 650 groups have registered with Astronomy On-line. Most come from 31 different European countries and a few dozen groups are located in North and South America as well as in Asia and Australia. Together they have experienced the steady build-up of Astronomy On-line over the past weeks, by means of numerous contributions from a

  10. Evaluation of Experimental Four-Day Week Class Schedule, January Through April 1974 at Lake City Community College.

    ERIC Educational Resources Information Center

    Hardman, Clark

    Due to the energy disturbance during the fall and winter of 1973-74, Lake City Community College experimented with a 4-days-per-week schedule of classes. a student evaluation of the 4-day week was completed by 58 percent of the full-time students. Fifty-one percent of the total student sample preferred the 4-day week, and 30 percent preferred the…

  11. 75 FR 71523 - National Farm-City Week, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-24

    ... Documents#0;#0; ] Proclamation 8605 of November 19, 2010 National Farm-City Week, 2010 By the President of... environmentally sustainable way of life for future generations. During National Farm-City Week, we recognize the... farms of every size that produce the abundance that graces our tables. During National Farm-City...

  12. 76 FR 22033 - National Maritime Week Tugboat Races, Seattle, WA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-20

    ... SECURITY Coast Guard 33 CFR Part 100 National Maritime Week Tugboat Races, Seattle, WA AGENCY: Coast Guard... Local Regulation for the annual National Maritime Week Tugboat Races in Elliott Bay, WA from 12 p.m... INFORMATION: The Coast Guard will enforce the Special Local Regulation for the annual National Maritime...

  13. Choose Privacy Week: Educate Your Students (and Yourself) about Privacy

    ERIC Educational Resources Information Center

    Adams, Helen R.

    2016-01-01

    The purpose of "Choose Privacy Week" is to encourage a national conversation to raise awareness of the growing threats to personal privacy online and in day-to-day life. The 2016 Choose Privacy Week theme is "respecting individuals' privacy," with an emphasis on minors' privacy. A plethora of issues relating to minors' privacy…

  14. 78 FR 37423 - National Small Business Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ... June 20, 2013 Part VI The President Proclamation 8994--National Small Business Week, 2013 Proclamation...; #0; #0;Title 3-- #0;The President ] Proclamation 8994 of June 14, 2013 National Small Business Week...--from small-town storefronts to pioneering startups that keep our country on the cutting edge. This...

  15. 7 CFR 59.204 - Mandatory weekly reporting for swine.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 3 2014-01-01 2014-01-01 false Mandatory weekly reporting for swine. 59.204 Section 59.204 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... (CONTINUED) LIVESTOCK MANDATORY REPORTING Swine Reporting § 59.204 Mandatory weekly reporting for swine....

  16. 7 CFR 59.204 - Mandatory weekly reporting for swine.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 3 2012-01-01 2012-01-01 false Mandatory weekly reporting for swine. 59.204 Section 59.204 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... (CONTINUED) LIVESTOCK MANDATORY REPORTING Swine Reporting § 59.204 Mandatory weekly reporting for swine....

  17. 7 CFR 59.204 - Mandatory weekly reporting for swine.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 3 2013-01-01 2013-01-01 false Mandatory weekly reporting for swine. 59.204 Section 59.204 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... (CONTINUED) LIVESTOCK MANDATORY REPORTING Swine Reporting § 59.204 Mandatory weekly reporting for swine....

  18. 7 CFR 59.204 - Mandatory weekly reporting for swine.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 3 2011-01-01 2011-01-01 false Mandatory weekly reporting for swine. 59.204 Section 59.204 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING... (CONTINUED) LIVESTOCK MANDATORY REPORTING Swine Reporting § 59.204 Mandatory weekly reporting for swine....

  19. 78 FR 57463 - National Farm Safety and Health Week, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-18

    ... Documents#0;#0; ] Proclamation 9017 of September 13, 2013 National Farm Safety and Health Week, 2013 By the.... During National Farm Safety and Health Week, we celebrate our agricultural producers' values, experiences, and contributions, and we recommit to secure work environments on all our country's farms. For...

  20. Sharing Skills: Reach for a Book; Book Week Puzzle Packet.

    ERIC Educational Resources Information Center

    Bauer, Caroline Feller

    1986-01-01

    Reach for a Book is the theme for Children's Book Week 1986, and book presentations, activities, and exhibits to emphasize the joy of reading are listed. A Book Week Puzzle Packet provides two puzzles designed to reinforce the idea of using the card catalog to find materials on specific subjects. (EM)

  1. 29 CFR 780.316 - Thirteen week provision.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... a self-employed farmer who works as a hand harvest laborer during part of the year is considered to... have been employed in agriculture less than 13 weeks during the preceding calendar year.” For purposes of determining whether a worker has been employed in agriculture less than 13 weeks during...

  2. 29 CFR 780.316 - Thirteen week provision.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... a self-employed farmer who works as a hand harvest laborer during part of the year is considered to... have been employed in agriculture less than 13 weeks during the preceding calendar year.” For purposes of determining whether a worker has been employed in agriculture less than 13 weeks during...

  3. 29 CFR 780.316 - Thirteen week provision.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... a self-employed farmer who works as a hand harvest laborer during part of the year is considered to... have been employed in agriculture less than 13 weeks during the preceding calendar year.” For purposes of determining whether a worker has been employed in agriculture less than 13 weeks during...

  4. 29 CFR 780.316 - Thirteen week provision.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... a self-employed farmer who works as a hand harvest laborer during part of the year is considered to... have been employed in agriculture less than 13 weeks during the preceding calendar year.” For purposes of determining whether a worker has been employed in agriculture less than 13 weeks during...

  5. 29 CFR 780.316 - Thirteen week provision.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a self-employed farmer who works as a hand harvest laborer during part of the year is considered to... have been employed in agriculture less than 13 weeks during the preceding calendar year.” For purposes of determining whether a worker has been employed in agriculture less than 13 weeks during...

  6. Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells

    PubMed Central

    Muñoz, Rosana; Edwards-Faret, Gabriela; Moreno, Mauricio; Zuñiga, Nikole; Cline, Hollis; Larraín, Juan

    2016-01-01

    Spinal cord regeneration is very inefficient in humans, causing paraplegia and quadriplegia. Studying model organisms that can regenerate the spinal cord in response to injury could be useful for understanding the cellular and molecular mechanisms that explain why this process fails in humans. Here, we use Xenopus laevis as a model organism to study spinal cord repair. Histological and functional analyses showed that larvae at pre-metamorphic stages restore anatomical continuity of the spinal cord and recover swimming after complete spinal cord transection. These regenerative capabilities decrease with onset of metamorphosis. The ability to study regenerative and non-regenerative stages in Xenopus laevis makes it a unique model system to study regeneration. We studied the response of Sox2/3 expressing cells to spinal cord injury and their function in the regenerative process. We found that cells expressing Sox2 and/or Sox3 are present in the ventricular zone of regenerative animals and decrease in non-regenerative froglets. Bromodeoxyuridine (BrdU) experiments and in vivo time-lapse imaging studies using green fluorescent protein (GFP) expression driven by the Sox3 promoter showed a rapid, transient and massive proliferation of Sox2/3+ cells in response to injury in the regenerative stages. The in vivo imaging also demonstrated that Sox2/3+ neural progenitor cells generate neurons in response to injury. In contrast, these cells showed a delayed and very limited response in non-regenerative froglets. Sox2 knockdown and overexpression of a dominant negative form of Sox2 disrupts locomotor and anatomical-histological recovery. We also found that neurogenesis markers increase in response to injury in regenerative but not in non-regenerative animals. We conclude that Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is

  7. Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells.

    PubMed

    Muñoz, Rosana; Edwards-Faret, Gabriela; Moreno, Mauricio; Zuñiga, Nikole; Cline, Hollis; Larraín, Juan

    2015-12-15

    Spinal cord regeneration is very inefficient in humans, causing paraplegia and quadriplegia. Studying model organisms that can regenerate the spinal cord in response to injury could be useful for understanding the cellular and molecular mechanisms that explain why this process fails in humans. Here, we use Xenopus laevis as a model organism to study spinal cord repair. Histological and functional analyses showed that larvae at pre-metamorphic stages restore anatomical continuity of the spinal cord and recover swimming after complete spinal cord transection. These regenerative capabilities decrease with onset of metamorphosis. The ability to study regenerative and non-regenerative stages in Xenopus laevis makes it a unique model system to study regeneration. We studied the response of Sox2(/)3 expressing cells to spinal cord injury and their function in the regenerative process. We found that cells expressing Sox2 and/or Sox3 are present in the ventricular zone of regenerative animals and decrease in non-regenerative froglets. Bromodeoxyuridine (BrdU) experiments and in vivo time-lapse imaging studies using green fluorescent protein (GFP) expression driven by the Sox3 promoter showed a rapid, transient and massive proliferation of Sox2(/)3(+) cells in response to injury in the regenerative stages. The in vivo imaging also demonstrated that Sox2(/)3(+) neural progenitor cells generate neurons in response to injury. In contrast, these cells showed a delayed and very limited response in non-regenerative froglets. Sox2 knockdown and overexpression of a dominant negative form of Sox2 disrupts locomotor and anatomical-histological recovery. We also found that neurogenesis markers increase in response to injury in regenerative but not in non-regenerative animals. We conclude that Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism

  8. Anoxic Androgen Degradation by the Denitrifying Bacterium Sterolibacterium denitrificans via the 2,3-seco Pathway

    PubMed Central

    Wang, Po-Hsiang; Yu, Chang-Ping; Lee, Tzong-Huei; Lin, Ching-Wen; Ismail, Wael; Wey, Shiaw-Pyng; Kuo, An-Ti

    2014-01-01

    The biodegradation of steroids is a crucial biochemical process mediated exclusively by bacteria. So far, information concerning the anoxic catabolic pathways of androgens is largely unknown, which has prevented many environmental investigations. In this work, we show that Sterolibacterium denitrificans DSMZ 13999 can anaerobically mineralize testosterone and some C19 androgens. By using a 13C-metabolomics approach and monitoring the sequential appearance of the intermediates, we demonstrated that S. denitrificans uses the 2,3-seco pathway to degrade testosterone under anoxic conditions. Furthermore, based on the identification of a C17 intermediate, we propose that the A-ring cleavage may be followed by the removal of a C2 side chain at C-5 of 17-hydroxy-1-oxo-2,3-seco-androstan-3-oic acid (the A-ring cleavage product) via retro-aldol reaction. The androgenic activities of the bacterial culture and the identified intermediates were assessed using the lacZ-based yeast androgen assay. The androgenic activity in the testosterone-grown S. denitrificans culture decreased significantly over time, indicating its ability to eliminate androgens. The A-ring cleavage intermediate (≤500 μM) did not exhibit androgenic activity, whereas the sterane-containing intermediates did. So far, only two androgen-degrading anaerobes (Sterolibacterium denitrificans DSMZ 13999 [a betaproteobacterium] and Steroidobacter denitrificans DSMZ 18526 [a gammaproteobacterium]) have been isolated and characterized, and both of them use the 2,3-seco pathway to anaerobically degrade androgens. The key intermediate 2,3-seco-androstan-3-oic acid can be used as a signature intermediate for culture-independent environmental investigations of anaerobic degradation of C19 androgens. PMID:24657867

  9. Laser-spectroscopy measurement of the fine-structure splitting 2 3P1-2 3P2 of 4He

    NASA Astrophysics Data System (ADS)

    Feng, G.-P.; Zheng, X.; Sun, Y. R.; Hu, S.-M.

    2015-03-01

    Laser spectroscopy has been performed on a beam of neutral 4He atoms. By using transverse laser cooling and focusing, we are able to prepare a bright beam of atoms in the metastable state 2 3S1 deflected from the original effusive atomic beam. The initial state preparation is completed with optical pumping on the 2 3P1←2 3S1 transition at the wavelength of 1083 nm, followed by laser spectroscopy on the 2 3P1 ,2←2 3S1 transitions. The 2 3P1-2 3P2 fine-structure splitting is determined to be 2 291 177.69 ±0.36 kHz . The quantum interference effect is included in data extraction. This is the most precise laser spectroscopy measurement of the interval. Our result is in agreement with both the latest QED-based calculation and the most precise measurement conducted with microwave spectroscopy.

  10. Preliminary assessment of RFI impacts on TDRSS in the 2- to 2.3 GHz band

    NASA Technical Reports Server (NTRS)

    Lyttle, J. D.

    1974-01-01

    A study was conducted of the radio frequency bands and radio frequency interference (RFI) impacts on the TDR satellite. Quick look evaluations were performed on RFI conditions in the 136 to 138 MHz and 400.5 to 401.5 MHz bands. An approximate chronological account of the investigations and the intermediate findings are presented. The preliminary results of RFI evaluations in the nominally 2 to 2.3 GHz band. An analysis of the time interaction of user satellites with microwave radio-relay type communications beams as a source of RFI is included.

  11. A new Main Injector radio frequency system for 2.3 MW Project X operations

    SciTech Connect

    Dey, J.; Kourbanis, I.; /Fermilab

    2011-03-01

    For Project X Fermilab Main Injector will be required to provide up to 2.3 MW to a neutrino production target at energies between 60 and 120 GeV. To accomplish the above power levels 3 times the current beam intensity will need to be accelerated. In addition the injection energy of Main Injector will need to be as low as 6 GeV. The current 30 year old Main Injector radio frequency system will not be able to provide the required power and a new system will be required. The specifications of the new system will be described.

  12. Facilitated extinction of morphine conditioned place preference with Tat-GluA2(3Y) interference peptide.

    PubMed

    Dias, C; Wang, Y T; Phillips, A G

    2012-08-01

    Neuroplasticity including long-term depression (LTD) has been implicated in both learning processes and addiction. LTD can be blocked by intravenous administration of the interference peptide Tat-GluA2(3Y) that prevents regulated endocytosis of the alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor. In this study, Tat-GluA2(3Y) was used to assess the role of LTD in the induction, expression, extinction and reinstatement of morphine-induced conditioned place preference (CPP). CPP was established in rats by pairing morphine (5 mg/kg, i.p.) or saline with a specific environmental context using a balanced protocol. Tat-GluA2(3Y) (0; 1.5; 2.25 nmol/g; i.v.), scrambled peptide (Tat-GluA2(Sc)), or vehicle was administered during the acquisition phase or prior to the test for CPP. Tat-GluA2(3Y) had no effect on the induction or initial expression of morphine-induced CPP. Rats that received Tat-GluA2(3Y) or Tat-GluA2(Sc) during acquisition were subsequently tested for 11 consecutive days in order to extinguish morphine CPP. CPP was then reinstated by an injection of morphine (5 mg/kg, i.p.). Co-administration of morphine and Tat-GluA2(3Y) during acquisition greatly facilitated extinction of CPP without affecting morphine-induced reinstatement of CPP. Using an intermittent retest schedule with bi-weekly tests to measure the maintenance of CPP, Tat-GluA2(3Y) during the acquisition phase had no effect on the maintenance of CPP. We propose that co-administration of Tat-GluA2(3Y) with morphine during acquisition of CPP weakens the association between morphine and contextual cues leading to rapid extinction of morphine CPP with repeated daily testing.

  13. Performance effects of 6 weeks of aerobic production training in junior elite soccer players.

    PubMed

    Ingebrigtsen, Jørgen; Shalfawi, Shaher A I; Tønnessen, Espen; Krustrup, Peter; Holtermann, Andreas

    2013-07-01

    This study investigates the performance effects of a 6-week biweekly anaerobic speed endurance production training among junior elite soccer players. Sixteen junior (age 16.9 ± 0.6 years) elite soccer players were tested in the Yo-Yo Intermittent Recovery test level 2 (IR2), 10-m and 35-m sprints, 7 × 35-m repeated-sprint ability (RSA) tests, countermovement jump and squat jump tests, and randomly assigned to either a control group (CG) performing their normal training schedule, which included 4 weekly soccer training sessions of approximately 90 minutes, or a training group performing anaerobic speed endurance production training twice weekly for 6 weeks in addition to their normal weekly schedule. We found that the intervention group significantly improved (p < 0.05) their performance in the Yo-Yo IR2 (63 ± 74 m) and 10-m sprint time (-0.06 ± 0.06 seconds). No significant performance changes were found in the CG. Between-group pretest to posttest differences were found for 10-m sprint times (p < 0.05). No significant changes were observed in the 35-m sprint times, RSA, or jump performances. These results indicate that short-term anaerobic production training is effective in improving acceleration and intermittent exercise performance among well-trained junior elite players.

  14. The effects of water-level fluctuations on weekly tree growth in a southeastern USA swamp

    SciTech Connect

    Keeland, B.D.; Sharitz, R.R.

    1997-01-01

    Annual growth of wetland trees has been shown to be related to variations in hydrologic regimes, however the relationship between water level fluctuations and tree growth season has not been documented. In a study of weekly growth patterns of three wetland tree species in a southeastern forested wetland, transfer function modeling was used to examine relationships between tree growth and the weekly changes in water levels and weekly changes in the atmospheric water balance (precipitation minus potential evapotranspiration). An autoregressive-moving average model was fit to each time series of water-level changes (input series), and the selected model was then used to filter the tree-growth (output) time series. Cross-correlations between each input and output time series were examined and significant relationships between weekly changes in water levels and tree diameter were found for Nyssa sylvatica and Taxodium distichum trees growing at sites with periodic shallow flooding. There were no significant relationships between changing water levels and tree growth in areas with permanent flooding or soil saturation. Further, changes in growth of N. sylvatica, N. aquatica, and T. distichum were significantly cross-correlated with weekly changes in the atmospheric water balance at sites with either periodic or permanent flooding. 59 refs., 9 figs., 5 tabs.

  15. The impact of a week of simulated night work on sleep, circadian phase, and performance

    PubMed Central

    Lamond, N; Dorrian, J; Roach, G; McCulloch, K; Holmes, A; Burgess, H; Fletcher, A; Dawson, D

    2003-01-01

    Methods: Fifteen healthy subjects participated in an adaptation and baseline night sleep, directly followed by seven simulated eight-hour night shifts (2300 to 0700 hours). At the end of each shift they were taken outside and exposed to natural light for 20 minutes. They then slept from approximately 0800 hours until they naturally awoke. Results: There was a significant increase in mean performance on a visual psychomotor vigilance task across the week. Daytime sleep quality and quantity were not negatively affected. Total sleep time (TST) for each of the daytime sleeps was reduced, resulting in an average cumulative sleep debt of 3.53 hours prior to the final night shift. TST for each of the daytime sleep periods did not significantly differ from the baseline night, nor did TST significantly vary across the week. There was a significant decrease in wake time after sleep onset and sleep onset latency across the week; sleep efficiency showed a trend towards greater efficiency across the consecutive daytime sleeps. Hours of wakefulness prior to each simulated night shift significantly varied across the week. The melatonin profile significantly shifted across the week. Conclusions: Results suggest that under optimal conditions, the sleep debt that accumulates during consecutive night shifts is relatively small and does not exacerbate decrements in night-time performance resulting from other factors. When sleep loss is minimised, adaptation of performance during consecutive night shifts can occur in conjunction with circadian adaptation. PMID:14573724

  16. Weeks Island gravity stable CO2 pilot: Final report

    SciTech Connect

    Johnston, J.R.; Perry, G.E.

    1989-01-01

    The Weeks Island ''S'' sand Reservoir B (''S'' RB) gravity-stable CO2 field test was completed during February 1988. Injection started in October 1978 and production began in January 1981 in this high-permeability, steeply-dipping sandstone reservoir. About 264,000 barrels of oil or 65 percent of the starting volume has been recovered. A 24-percent pore-volume slug of CO2 mixed with about six mole percent of natural gas (mostly methane) was injected at the start of the pilot. Since 1983, produced CO2 plus hydrocarbon gases have been recycled. CO2 usage statistics are 9.34 MCF/BO with recycle and 3.24 MCF/BO based on purchased CO2. Previous annual reports document the pilot design, implementation, and early results for the 1977 to June 1981 time period. This report is a review of early pilot history and a more detailed account of the post June 1981 results and overall interpretation. A reservoir-simulation history match of pilot performance plus core and log data from a 1983 swept-zone evaluation well are described in this report. A brief description of the production facility and an account of the corrosion control program are also included. 11 refs., 34 figs.

  17. RPR Titer Variation in the Two Weeks Following Syphilis Therapy

    PubMed Central

    Holman, Katherine M.; Wolff, Mark; Seña, Arlene C.; Martin, David H.; Behets, Frieda; Van Damme, Kathleen; Leone, Peter; McNeil, Linda; Gehrig, Meredyth L.; Hook, Edward W.

    2012-01-01

    Background Serologic tests for syphilis (STS) results at time of diagnosis are the basis for evaluating response to syphilis therapy. Following treatment, however, STS titers may continue to increase for several weeks. We evaluated RPR titer variation over the 14 days following therapy using data from a recent large, prospective RCT. Methods Prospectively enrolled participants in North America and Madagascar with primary, secondary or early latent syphilis were randomly assigned to penicillin, doxycycline (in the case of penicillin allergy) or azithromycin treatment. Blood for RPR analysis was drawn at days 0, 7, and 14 post-treatment. All RPR titers were determined simultaneously at a central laboratory. Results 470 patients had data available for at least 2 of 3 RPR measurements. Overall, 20% of patients showed a titer increase of at least one dilution in the 14 days following therapy. The greatest proportion of titer increases following therapy was seen in patients with primary syphilis. Comparing outcome of therapy using the initial (day 0) RPR titer vs. the maximal RPR titer (over 14 days), resulted in outcome reclassification in 2.98% of participants. Conclusions Despite the fact that about 20% of early syphilis patients had increases in RPR titers immediately following treatment, these changes rarely influenced assessment of therapeutic outcome. Only 3% of patients treated would have been reclassified. PMID:22801348

  18. Chronic flexibility improvement after 12 week of stretching program utilizing the ACSM recommendations: hamstring flexibility.

    PubMed

    Sainz de Baranda, P; Ayala, F

    2010-06-01

    The ACSM flexibility training recommendations emphasize proper stretching of muscles supporting the major joints, but there is a little evidence to support this recommendation in terms of effectiveness, and which stretching parameters (technique and single stretch duration) are more adequate. A randomized controlled clinical trial design was use to investigate whether the ACSM flexibility training recommendation parameters improve hip flexion range of motion. A total of 173 subjects, 122 men (21.3+/-2.5 years; 176.33+/-8.35 cm; 74.42+/-10.80 kg) and 51 women (20.7+/-1.6 years; 163.43+/-6.57 cm; 60.12+/-7.88 kg), classified as recreationally active young adult university students were randomly assigned to 1 of 7 groups: 1 control group (no stretching) or 1 of 6 stretching groups. All stretching groups performed 12 weeks of flexibility training with a consistent stretch daily dose (180 s) and frequency (3 days per week) parameters and different stretch technique (passive or active) and single stretch duration (15, 30, or 45 s). Hip flexion passive range of motion (PROM) was determined through the bilateral straight-leg raise test before, during (at 4 and 8 weeks), and after the program (12 weeks). All stretching groups performed hip flexion PROM after flexibility training. A significant improvement was identified in mean PROM for each stretching group, but no significant differences were found between stretch technique and single stretch duration (p>0.05). The control group's mean PROM decreased (Delta PROM: -0.08 degrees, 95% confidence interval [CI]=-2.3 to 5.3), whereas all stretching groups increased PROM (Delta PROM: 15.14 degrees, 95% CI=10.19 to 23.56) in hip flexion after 12 weeks of stretching (p<0.05). The present study suggests that the current ACSM flexibility training recommendations are effective for improving hip flexion ROM in recreationally active young adults.

  19. Comparison of different dosing regimens (once weekly vs. twice weekly, and once weekly vs. once every two weeks) with epoetin delta in patients with chronic kidney disease: a randomized controlled trial

    PubMed Central

    Macdougall, Iain C

    2007-01-01

    Background Anaemia is a common complication of chronic kidney disease and prevalence increases with declining renal function. Renal anaemia has significant implications for the well-being and quality of life of patients and impacts on morbidity and mortality. Anaemia can be well managed by therapy with erythropoiesis-stimulating agents (ESAs). Previous clinical trials have shown that the only human cell-line-derived ESA, epoetin delta, is well tolerated and effective in maintaining haemoglobin levels in anaemic patients with chronic kidney disease. The half-life of epoetin delta suggests that administration of this agent is feasible once weekly and once every two weeks. We report on the design and rationale of a trial to compare once weekly vs. twice weekly, and once weekly vs. once every two weeks dosing of epoetin delta. Design and methods This is a randomized, open-label, multicentre trial. Patients aged 18 years or above with chronic kidney disease (Stages 3–5) are eligible to enter this trial. Two groups of patients form the trial population, those naïve to ESA therapy and those previously stable on ESA therapy. There are two primary objectives of this trial: 1) to demonstrate non-inferiority between twice weekly and once weekly dosing of epoetin delta in previously naïve patients (assessed by haemoglobin at Week 24); 2) to demonstrate non-inferiority between once weekly and once every two weeks dosing in previously stable patients (assessed by average haemoglobin over Weeks 16–24). Among the secondary analyses will be assessments of haematocrit, number(%) of patients meeting predefined targets for haemoglobin and haematocrit levels, and comparisons of average dose. All patients will receive study medication for 24 weeks and dose will be adjusted according to a predefined algorithm to achieve and maintain haemoglobin ≥ 11 g/dL. All patients completing this trial are eligible to enter a 2-year follow-up study to enable monitoring of emergent adverse

  20. 29 CFR 3.4 - Submission of weekly statements and the preservation and inspection of weekly payroll records.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Submission of weekly statements and the preservation and inspection of weekly payroll records. 3.4 Section 3.4 Labor Office of the Secretary of Labor CONTRACTORS AND SUBCONTRACTORS ON PUBLIC BUILDING OR PUBLIC WORK FINANCED IN WHOLE OR IN PART BY LOANS OR GRANTS FROM THE...

  1. How to implement once a week recycling, once a week trash pick-up and live to tell about it

    SciTech Connect

    Reighart, C.M.

    1996-08-01

    The implementation of a recycling program in Maryland is described. The program involved changing from a biweekly trash collection to a once a week trash collection and a once a week recyclable collection; public resistance to the change was anticipated. Major program elements included pilot programs and gradual implementation of the new program. Public reaction to the new program has been generally favorable.

  2. The effect of 48 weeks of aerobic exercise training on cutaneous vasodilator function in post-menopausal females.

    PubMed

    Hodges, Gary J; Sharp, Lisa; Stephenson, Claire; Patwala, Ashish Y; George, Keith P; Goldspink, David F; Tim Cable, N

    2010-04-01

    Skin blood flow (SkBF) and endothelial-dependent vasodilatation decline with ageing and can be reversed with exercise training. We tested whether 48 weeks of training could improve SkBF and endothelial function in post-menopausal females; 20 post-menopausal subjects completed the study. SkBF was measured by laser-Doppler flowmetry (LDF). Cutaneous vascular conductance (CVC) was calculated as LDF/blood pressure. Resting CVC was measured at 32 degrees C and peak CVC at 42 degrees C. Cutaneous endothelial-dependent and -independent vasodilatations were determined by the iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP), respectively. All assessments described were performed at entry (week 0), and after 6, 12, 24, 36, and 48 weeks of training. Resting CVC measures did not change (P > 0.05) throughout the study. Peak CVC increased (P < 0.05) after 24 weeks (7.2 +/- 1.2 vs. 11.6 +/- 1.4 AU mmHg(-1)) and at the 36- and 48-week assessments (13.0 +/- 1.7 and 14.9 +/- 2.1 AU mmHg(-1), respectively). Responses to ACh also increased (P < 0.05) at the 24-week assessment (5.1 +/- 2.1 vs. 8.55 +/- 2.3 AU mmHg(-1)) and increased further at the 36 and 48-week assessments (11.6 +/- 3.7 and 13.2 +/- 3.9 AU mmHg(-1), respectively). Cutaneous responses to SNP increased (P < 0.05) after 36 weeks (8.7 +/- 2.1 vs. 13.02 +/- 2.23 AU mmHg(-1) at 36 weeks). VO(2max) increased after 12 weeks (23.5 +/- 0.7 vs. 25.4 +/- 0.9 ml kg(-1) min(-1)) and improved (P < 0.05) further throughout the study (31.6 +/- 1.8 ml kg(-1) min(-1) at week 48). Aerobic exercise produces positive adaptations in the cutaneous vasodilator function to local heating as well as in cutaneous endothelial and endothelial-independent vasodilator mechanisms. Aerobic capacity was also significantly improved. These adaptations were further enhanced with progressive increases in exercise intensity.

  3. Pathway of actin filament branch formation by Arp2/3 complex revealed by single-molecule imaging

    PubMed Central

    Smith, Benjamin A.; Daugherty-Clarke, Karen; Goode, Bruce L.; Gelles, Jeff

    2013-01-01

    Actin filament nucleation by actin-related protein (Arp) 2/3 complex is a critical process in cell motility and endocytosis, yet key aspects of its mechanism are unknown due to a lack of real-time observations of Arp2/3 complex through the nucleation process. Triggered by the verprolin homology, central, and acidic (VCA) region of proteins in the Wiskott-Aldrich syndrome protein (WASp) family, Arp2/3 complex produces new (daughter) filaments as branches from the sides of preexisting (mother) filaments. We visualized individual fluorescently labeled Arp2/3 complexes dynamically interacting with and producing branches on growing actin filaments in vitro. Branch formation was strikingly inefficient, even in the presence of VCA: only ∼1% of filament-bound Arp2/3 complexes yielded a daughter filament. VCA acted at multiple steps, increasing both the association rate of Arp2/3 complexes with mother filament and the fraction of filament-bound complexes that nucleated a daughter. The results lead to a quantitative kinetic mechanism for branched actin assembly, revealing the steps that can be stimulated by additional cellular factors. PMID:23292935

  4. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in a mutant mouse model of Rett syndrome

    PubMed Central

    Wood, Lydia; Shepherd, Gordon M. G.

    2010-01-01

    Motor and cognitive functions are severely impaired in Rett syndrome (RTT). Here, we examined local synaptic circuits of layer 2/3 (L2/3) pyramidal neurons in motor-frontal cortex of male hemizygous MeCP2-null mice at 3–4 weeks of age. We mapped local excitatory input to L2/3 neurons using glutamate uncaging and laser scanning photostimulation, and compared synaptic input maps recorded from MeCP2-null and wild type (WT) mice. Local excitatory input was significantly reduced in the mutants. The strongest phenotype was observed for lateral (horizontal, intralaminar) inputs, that is, L2/32/3 inputs, which showed a large reduction in MeCP2−/y animals. Neither the amount of local inhibitory input to these L2/3 pyramidal neurons nor their intrinsic electrophysiological properties differed by genotype. Our findings provide further evidence that excitatory networks are selectively reduced in RTT. We discuss our findings in the context of recently published parallel studies using selective MeCP2 knockdown in individual L2/3 neurons. PMID:20138994

  5. Prevention of disuse osteoporosis: Effect of sodium fluoride during five weeks of bed rest

    NASA Technical Reports Server (NTRS)

    Schneider, Victor S.

    1987-01-01

    An attempt was made to modify factors which promote disuse osteoporosis and thereby prevent it from occurring. Since fluoride is currently used to enhance bone formation in the treatment of low turnover osteoporosis, it was hypothesized that if the fluoride ion was available over a long period of time that it would slow the demonstrated loss of calcium by inhibiting bone resorption and enhancing bone formation. This study was used to determine whether oral medication with sodium F will modify or prevent 5 weeks of bed rest induced disuse osteoporosis, to determine the longitudinal effects of 5 weeks of bed rest on PTH, CT and calcitriol, to measure muscle volume changes and metabolic activity by magnetic resonance imaging and magnetic resonance spectroscopy during prolonged bed rest, to measure changes in peak muscle strength and fatigability, and to measure bone turnover in bone biopsies. Subjects were studied during 1 week of equilibration, 4 weeks of control ambulation, 5 weeks of bed rest, and 1 week of reambulation.

  6. Day-of-week trends in carbonaceous aerosol composition in the urban atmosphere

    NASA Astrophysics Data System (ADS)

    Lough, G. C.; Schauer, J. J.; Lawson, D. R.

    The chemical composition of atmospheric particulate matter was measured at two sites near Los Angeles, California, over 3 weeks in July 2001, as part of the Gasoline/Diesel PM Split Study. Samples were composited for organic speciation analysis by day of week at each site to investigate weekly trends in chemical composition of the carbonaceous fraction of particulate matter. Observed weekly trends in elemental carbon (EC), hopanes, steranes, and polynuclear aromatic hydrocarbons (PAHs) indicate increased impacts of motor vehicle traffic on carbonaceous particulate matter concentrations on weekdays relative to weekends. Ambient average EC was approximately 4 times higher in the Friday samples than in Sunday samples at each site. Levoglucosan, a tracer species for biomass burning, and cholesterol, monopalmitin, and monostearin, tracers for food cooking operations, were all highest on Friday and lowest on Sunday. Late-week increases in aliphatic and aromatic diacids present in the particulate phase were also observed. Diacids in particulate matter have been seen to be indicators of secondary organic aerosol formation, and the day-of-week trend observed may be due to weekday increases in volatile precursor species present in the atmosphere.

  7. Weekly bull exchange shortens postpartum anestrus in suckled beef cows.

    PubMed

    Miller, V; Ungerfeld, R

    2008-05-01

    The duration of anestrus in cattle was usually shortened when cows were exposed to bulls. The objective of the present experiment was to determine if weekly bull exchange accelerated the resumption of cyclicity in postpartum suckled beef cows. We tested the hypothesis that exposure of postpartum, anestrous, suckled beef cows (extensively managed) to weekly exchange of bulls, accelerates the resumption of cyclicity, compared to continuous exposure to the same bulls. Ninety-one multiparous suckled Hereford and Hereford x Angus cows, <60d postpartum, were assigned to two homogeneous groups. Beginning on December 1st (late spring), the control group (C, n=45) remained with one pair of bulls throughout the breeding period (7 weeks), whereas in the "exchanged" (E, n=46) group two pairs of bulls were exchanged weekly. Based on weekly ultrasonographic examinations of all cows, none had a CL at the start of the experiment and for 2 weeks after the start of bull exposure. However, the accumulated frequency of cows with a CL was greater in group E than in group C cows on week 4 (P=0.024), as well as on weeks 5-7 (P<0.001) after the start of bull exposure. Furthermore, in group E versus group C, there was a higher pregnancy rate 30d after the end of bull exposure (26 of 46, 56.2% vs. 16 of 45, 35.6%; P=0.045). In conclusion, weekly exchange of two pairs of bulls shortened postpartum anestrus in suckled multiparous cows, compared to continuous exposure to a single pair of bulls.

  8. A Pilot Study of pNGVL4a-CRT/E7(detox) for the Treatment of Patients with HPV16+ Cervical Intraepithelial Neoplasia 2/3 (CIN2/3)

    PubMed Central

    Alvarez, Ronald D.; Huh, Warner K.; Bae, Sejong; Lamb, Lawrence S.; Conner, Michael G.; Boyer, Jean; Wang, Chenguang; Hung, Chien-Fu; Sauter, Elizabeth; Paradis, Mihaela; Adams, Emily A.; Hester, Shirley; Jackson, Bradford E.; Wu, T.C.; Trimble, Cornelia

    2015-01-01

    Objective The purpose of this study was to evaluate the safety, efficacy, and immunogenicity of a plasmid vaccine, pNGVL4a-CRT-E7(detox), administered either intradermally, intramuscularly, or directly into the cervical lesion, in patients with HPV16-associated CIN2/3. Methods Eligible patients with HPV16+ CIN2/3 were enrolled in treatment cohorts evaluating pNGVL4a-CRT-E7(detox), administered by either particle-mediated epidermal delivery (PMED), intramuscular injection (IM), or cervical intralesional injection, at study weeks 0, 4, and 8. Patients were monitored for local injection site and systemic toxicity. A standard therapeutic resection was performed at week 15. The primary endpoints were safety and tolerability. Secondary endpoints included histologic regression and change in cervical HPV viral load. Exploratory endpoints included immune responses in the blood and in the target tissue. Results Thirty-two patients with HPV16+ CIN2/3 were enrolled onto the treatment phase of the study, and were vaccinated. Twenty-two of 32 patients (69%) experienced vaccine-specific related adverse events. The most frequent vaccine-related events were constitutional and local injection site in nature, and were grade 1 or less in severity. Histologic regression to CIN 1 or less occurred in 8 of 27 (30%) patients who received all vaccinations and underwent LEEP. In subject-matched comparisons, intraepithelial CD8+ T cell infiltrates increased after vaccination in subjects in the intralesional administration cohort. Conclusion pNGVL4a-CRT-E7(detox) was well-tolerated, elicited the most robust immune response when administered intralesionally, and demonstrated preliminary evidence of potential clinical efficacy. PMID:26616223

  9. Effect of the Refrigerator Storage Time on the Potency of Botox for Human Extensor Digitorum Brevis Muscle Paralysis

    PubMed Central

    Ahn, Ki Young

    2013-01-01

    Background and Purpose It is recommended that Botox be used within 5 hours of reconstitution, which results in substantial quantities being discarded. This is not only uneconomic, but also inconvenient for treating patients. The aim of this study was to determine the potencies of Botox used within 2 hours of reconstitution with unpreserved saline, the same Botox refrigerated (at +4℃) 72 hours after reconstitution, and during the next 4 consecutive weeks (weeks 1, 2, 3, and 4). This comparison was used to determine the length of refrigeration time during which reconstituted Botox will maintain the same efficacy as freshly reconstituted toxin. Methods Individual paralysis rates in the extensor digitorum brevis (EDB) compound muscle action potential (CMAP) amplitude and area were measured 1 week after injecting fresh reconstituted 2.5 MU of Botox on one side of the foot, and when the same quantity of Botox that had been refrigerated for a designated time (i.e., 72 h, or 1, 2, 3, or 4 weeks) into the other side of the foot. The EDB CMAP amplitude and area at 12 and 16 weeks postinjection were also measured to compare the efficacy durations in all five comparative groups. Results Ninety-four volunteers were divided into five groups according to the refrigerator storage time of the second Botox injection. The paralysis of the EDBs was significant for each injection of Botox, both fresh and refrigerated, with no statistically significant differences between them, regardless of the refrigeration time. There was a tendency toward increased CMAP amplitude and area at 12 or 16 weeks postinjection (p<0.0001). The duration of effective muscle paralysis did not differ significantly throughout the 16-week follow-up period between all five groups. Conclusions The potency of reconstituted Botox is not degraded by subsequent refrigeration for 4 weeks. However, there are definite concerns regarding its sterility, and hence its safety, since multiple withdrawals from the same vial

  10. Aerosol and cloud relations and weekly cycles over Central Europe

    NASA Astrophysics Data System (ADS)

    Kourtidis, K.; Georgoulias, A.; Alexandri, G.

    2012-04-01

    In this work, the aerosol and cloud relationships and weekly cycle patterns over Central Europe are examined using level-2 aerosol data from the TERRA MODIS satellite instrument to compile a decadal (2000-2010) 0.1 x 0.1 degree resolution gridded dataset as well as and total cloud cover (TCC) TERRA MODIS data and coarser resolution ISCCP TCC data. Aerosols and TCC were found to be positively correlated for all seasons, the slope of the correlation being slightly higher for low AOD values. A co-examination of AOD, TCC and NCAR/NCEP sea level pressure shows that the positive AOD-TCC correlation holds separately in all pressure bins, thus indicating that the correlation is not a synoptic artefact. A study of the weekly cycle of AOD shows that the main part of the positive (i.e. with midweek peak) weekly cycle plume extends over the central part of Central Europe, with the weekly cycle index (WCI) levels gradually decreasing until the weekly cycle becomes negative (i.e. with weekend peak) when moving away. No clear connection between the WCI patterns and topography was found while there is an apparent correlation between positive weekly cycles in summer and population density. A clear Monday minimum appears over regions with high positive WCI. Monday shifts to Tuesday when moving to the East, indicating aerosol transport from the dominating westerly wind flow. The WCI values and the average percent departures (APDs) for the day of weekly maximum and minimum were examined for 22 selected stations from previous ground-based weekly cycle studies. The weekly cycle is positive and statistically significant for only a few stations situated in France, Germany, Czech Republic and Belgium. A comparison with 1 x 1 degree level-3 MODIS TERRA data shows that in most cases level-3 data can give an indication of the local aerosol weekly cycle strength and phase. The satellite derived day of the weekly maximum and minimum is, generally, in line with results from ground-based studies

  11. Collecting biological material from palliative care patients in the last weeks of life: a feasibility study

    PubMed Central

    Scott, Aileen; Nwosu, Amara Callistus; Latten, Richard; Wilson, James; Mayland, Catriona R; Mason, Stephen; Probert, Chris; Ellershaw, John

    2016-01-01

    Objective To assess the feasibility of prospectively collecting biological samples (urine) from palliative care patients in the last weeks of life. Setting A 30-bedded specialist hospice in the North West of England. Participants Participants were adults with a diagnosis of advanced disease and able to provide written informed consent. Method Potential participants were identified by a senior clinician over a 12-week period in 2014. They were then approached by a researcher and invited to participate according to a developed recruitment protocol. Outcomes Feasibility targets included a recruitment rate of 50%, with successful collection of samples from 80% who consented. Results A total of 58 patients were approached and 33 consented (57% recruitment rate). Twenty-five patients (43%) were unable to participate or declined; 10 (17%) became unwell, too fatigued, lost capacity, died or were discharged home; and 15 (26%) refused, usually these patients had distressing pain, low mood or profound fatigue. From the 33 recruited, 20 participants provided 128 separate urine samples, 12 participants did not meet the inclusion criteria at the time of consent and 1 participant was unable to provide a sample. The criterion for a urinary catheter was removed for the latter 6 weeks. The collection rate during the first 6 weeks was 29% and 93% for the latter 6 weeks. Seven people died while the study was ongoing, and another 4 participants died in the following 4 weeks. Conclusions It is possible to recruit and collect multiple biological samples over time from palliative care patients in the last weeks and days of life even if they have lost capacity. Research into the biological changes at the end of life could develop a greater understanding of the biology of the dying process. This may lead to improved prognostication and care of patients towards the end of life. PMID:28186928

  12. Health markers in obese adolescents improved by a 12-week recreational soccer program: a randomised controlled trial.

    PubMed

    Vasconcellos, Fabrício; Seabra, Andre; Cunha, Felipe; Montenegro, Rafael; Penha, Jociene; Bouskela, Eliete; Nogueira Neto, José Firmino; Collett-Solberg, Paulo; Farinatti, Paulo

    2016-01-01

    The effects of a recreational soccer program (RSP) upon body composition, heart rate variability (HRV), biochemical markers, cardio-respiratory fitness, and endothelial function in obese adolescents were investigated. A randomised controlled clinical trial was conducted with 30 adolescents aged 12-17 years and body mass index (BMI) >2 standard deviations of WHO reference values, which were assigned to RSP (n = 10, 2 girls) and obese control (n = 10, 4 girls) groups. The 12-week RSP included 60-min sessions performed 3 times/week. BMI, waist circumference, blood pressure, blood glucose, lipid profile, insulin, C-reactive protein, HRV, and maximal oxygen consumption (VO2peak) were evaluated following standardised procedures. Body composition was determined by dual-energy X-ray absorptiometry and endothelial function by venous occlusion plethysmography. After intervention, RSP exhibited significant reductions in BMI (-0.7 ± 0.2 kg · m(-2)), waist circumference (-8.2 ± 1.4 cm), %body fat (-2.2 ± 0.4%), systolic blood pressure (-5.0 ± 2.3 mmHg), total cholesterol (-16.2 ± 5.8 mg · dL(-1)), triglycerides (-20.5 ± 12.9 mg · dL(-1)), C-reactive protein (-0.06 ± 0.01 mg · dL(-1)), insulin resistance (HOMA-IR, -1.4 ± 0.6), and sympathetic activity (LF, -13.9 ± 6.6 un) vs. controls (P < 0.05). Significant increase was observed in parasympathetic activity (HF, 13.9 ± 6.6 un), VO2peak (7.9 ± 2.8 ml · kg(-1) · min(-1)), and high-density lipoprotein cholesterol (11.0 ± 6.3 mg · dL(-1)) (P < 0.05). Vascular conductance (19.5 ± 8.1 ml · min(-1) · 100 ml, P = 0.005) increased and vascular resistance (-5.9 ± 2.4 ml · min(-1) · 100 ml, P = 0.041) decreased in RSP, but not in controls. A 12-week recreational soccer intervention was effective to improve biochemical, cardiovascular, and fitness health markers in obese adolescents.

  13. Sprint and vertical jump performances are not affected by six weeks of static hamstring stretching.

    PubMed

    Bazett-Jones, David M; Gibson, Mark H; McBride, Jeffrey M

    2008-01-01

    The purpose of this study was to investigate whether 6 weeks of static hamstring stretching effects range of motion (ROM), sprint, and vertical jump performances in athletes. Twenty-one healthy division III women's track and field athletes participated in the study. Subjects were tested for bilateral knee ROM; 55-m sprint time; and vertical jump height before, at 3 weeks, and after the 6-week flexibility program. Subjects were randomly assigned to treatment and control groups and warmed up with a 10-minute jog on a track before a hamstring stretching protocol. The stretching protocol consisted of four repetitions held for 45 seconds, 4 days per week. Four variables (left and right leg ROM, 55-m sprint time, vertical jump) were analyzed using a repeated-measures analysis of variance design. No significant differences (P < or = 0.05) were found with any of the four variables between the stretching and control groups. Six weeks of a static hamstring stretching protocol did not improve knee ROM or sprint and vertical jump performances in women track and field athletes. The use of static stretching should be restricted to post practice or competition because of the detrimental effects reported throughout the literature. Based on the current investigation, it does not seem that chronic static stretching has a positive or negative impact on athletic performance. Thus, the efficacy of utilizing this practice is questionable and requires further investigation.

  14. DSN seven day/twelve week schedule program

    NASA Technical Reports Server (NTRS)

    Holzman, R. E.

    1968-01-01

    Deep Space Network scheduling program allocates resources based on the users requirements. The system reviews and allocates the requests for equipment and resources. Depending upon the program input either the seven day or the twelve week schedule is generated.

  15. ISS Update: Weekly Recap for April 13, 2012

    NASA Video Gallery

    The International Space Station Weekly Recap for April 9-13, 2012. Questions? Ask us on Twitter @NASA_Johnson and include the hashtag #askStation. For the latest news about the space station, visit...

  16. ISS Update: Weekly Recap for April 6, 2012

    NASA Video Gallery

    The International Space Station Weekly Recap for April 2-6, 2012. Questions? Ask us on Twitter @NASA_Johnson and include the hashtag #askStation. For the latest news about the space station, visit ...

  17. 46 CFR 131.560 - Weekly tests and inspections.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... week if the battery is— (1) Of a type that requires recharging; and (2) Not connected to a device that... temperature required for starting the engine. (c) The general alarm system must be activated. (d) Each...

  18. 46 CFR 122.720 - Weekly maintenance and inspections.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... battery for rescue boat engine starting must be brought up to full charge at least once each week if: (1) The battery is of a type that requires recharging; and (2) The battery is not connected to a...

  19. The Arp2/3 Complex Is Essential for Distinct Stages of Spine Synapse Maturation, Including Synapse Unsilencing

    PubMed Central

    Spence, Erin F.; Kanak, Daniel J.; Carlson, Benjamin R.

    2016-01-01

    Dendritic filopodia are actin-rich structures that are thought to contribute to early spine synapse formation; however, the actin regulatory proteins important for early synaptogenesis are poorly defined. Using organotypic hippocampal slice cultures and primary neuron hippocampal cultures from Arp2/3 conditional knock-out mice, we analyze the roles of the Arp2/3 complex, an actin regulator that creates branched actin networks, and demonstrate it is essential for distinct stages of both structural and functional maturation of excitatory spine synapses. Our data show that initially the Arp2/3 complex inhibits the formation of dendritic filopodia but that later during development, the Arp2/3 complex drives the morphological maturation from filopodia to typical spine morphology. Furthermore, we demonstrate that although the Arp2/3 complex is not required for key spine maturation steps, such as presynaptic contact and recruitment of MAGUK (membrane-associated guanylate kinase) scaffolding proteins or NMDA receptors, it is necessary for the recruitment of AMPA receptors. This latter process, also known as synapse unsilencing, is a final and essential step in the neurodevelopment of excitatory postsynaptic synaptogenesis, setting the stage for neuronal interconnectivity. These findings provide the first evidence that the Arp2/3 complex is directly involved in functional maturation of dendritic spines during the developmental period of spinogenesis. SIGNIFICANCE STATEMENT Excitatory spine synapse formation (spinogenesis) is a poorly understood yet pivotal period of neurodevelopment that occurs within 2–3 weeks after birth. Neurodevelopmental disorders such as intellectual disability and autism are characterized by abnormal spine structure, which may arise from abnormal excitatory synaptogenesis. The initial stage of spinogenesis is thought to begin with the emergence of actin-rich dendritic filopodia that initiate contact with presynaptic axonal boutons. However, it

  20. 3 CFR 8521 - Proclamation 8521 of May 14, 2010. World Trade Week, 2010

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... fiber optic lines, we will send our goods and services to every corner of the globe. Together, we will... more remain underemployed, limited to part-time work or odd jobs. To help them, we must do all we can... work, ingenuity, optimism, and common purpose. This week, let us renew the enduring principles...