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Sample records for 200 200c 300

  1. 76 FR 12619 - Airworthiness Directives; The Boeing Company 737-200, -200C, -300, -400, and -500 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ...-18-06, Amendment 39-13784 (69 FR 54206, September 8, 2004), for certain Model 737-200, -200C, -300... 12866, (2) Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034...), 40113, 44701. Sec. 39.13 2. The FAA amends Sec. 39.13 by removing amendment 39-13784 (69 FR...

  2. 76 FR 54399 - Airworthiness Directives; The Boeing Company Model 737-200, -200C, -300, -400, and -500 Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-01

    ... 2010-01-09, Amendment 39-16167 (75 FR 1527, January 12, 2010), for certain Model 737-300, -400, and... a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26...-09, Amendment 39-16167 (75 FR 1527, January 12, 2010), and adding the following new AD: The...

  3. DYNAMIC LOADING OF TEFLON AT 200?C

    SciTech Connect

    Urtiew, P A; Forbes, J W; Tarver, C M; Vandersall, K S; Garcia, F

    2007-06-13

    Dynamic loading experiments were performed on inert Teflon (Polytetrafluoroethylene) samples, initially heated to the temperature of 200 C, to test its behavior under these conditions for its use in other heated experiments. Tests were performed in the 100 mm diameter bore propellant driven gas gun with piezo-resistive manganin pressure gauges imbedded into the samples to measure loading pressures. Experimental data provided new information on the shock velocity - particle velocity relationship for the heated material and showed no adverse effect of temperature on the insulating properties of the material.

  4. 1 GHz, 200 C, SiC MESFET Clapp Oscillator

    NASA Technical Reports Server (NTRS)

    Ponchak, George E.; Schwartz, Zachary D.

    2005-01-01

    A SiC Clapp oscillator frabricated on an alumina substrate with chip capacitors and spiral inductors is designed for high temperature operation at 1 gigahertz. The oscillator operated from 30 to 200 C with an output power of 21.8 dBm at 1 gigahertz and 200 C. The efficiency at 200 C is 15 percent. The frequency variation over the temperature range is less than 0.5 percent.

  5. Operational characteristics of a 200 C LC parallel resonant circuit

    NASA Technical Reports Server (NTRS)

    Baumann, Eric D.; Hammoud, Ahmad N.

    1995-01-01

    Research efforts are currently underway at the NASA Lewis Research Center to design and demonstrate an inverter capable of operating with a baseplate temperature of 200 C. In support of this project, various electrical components including capacitors, inductors, transformers, cables, and semiconductor switches are being developed or evaluated for integration into the inverter. In this work, a parallel LC resonant circuit was constructed and evaluated under simultaneous electrical and thermal stressing. The tests were performed in the temperature range of 25 to 200 C with an applied voltage of up to 90 V, 20 kHz. The individual components were comprised of high temperature film capacitors and powder core inductors developed in-house. The circuit was characterized in terms of the component currents and case temperatures as well as frequency of resonance as a function of applied bias and temperature. The results obtained, which have indicated good functional stability up to 200 C, are presented and discussed.

  6. miR-200c dampens cancer cell migration via regulation of protein kinase A subunits.

    PubMed

    Sigloch, Florian Christoph; Burk, Ulrike Christina; Biniossek, Martin Lothar; Brabletz, Thomas; Schilling, Oliver

    2015-09-15

    Expression of miR-200c is a molecular switch to determine cellular fate towards a mesenchymal or epithelial phenotype. miR-200c suppresses the early steps of tumor progression by preventing epithelial-mesenchymal transition (EMT) and intravasation of tumor cells. Unraveling the underlying molecular mechanisms might pinpoint to novel therapeutic options. To better understand these mechanisms it is crucial to identify targets of miR-200c. Here, we employ a combination of quantitative proteomic and bioinformatic strategies to identify novel miR-200c targets. We identify and confirm two subunits of the central cellular kinase protein kinase A (PKA), namely PRKAR1A and PRKACB, to be directly regulated by miR-200c. Notably, siRNA-mediated downregulation of both proteins phenocopies the migratory behavior of breast cancer cells after miR-200c overexpression. Patient data from publicly accessible databases supports a miR-200c-PKA axis. Thus, our study identifies the PKA heteroprotein as an important mediator of miR-200c induced repression of migration in breast cancer cells. By bioinformatics, we define a miRNA target cluster consisting of PRKAR1A, PRKAR2B, PRKACB, and COF2, which is targeted by a group of 14 miRNAs. PMID:26203557

  7. miR-200c dampens cancer cell migration via regulation of protein kinase a subunits

    PubMed Central

    Biniossek, Martin Lothar; Brabletz, Thomas; Schilling, Oliver

    2015-01-01

    Expression of miR-200c is a molecular switch to determine cellular fate towards a mesenchymal or epithelial phenotype. miR-200c suppresses the early steps of tumor progression by preventing epithelial-mesenchymal transition (EMT) and intravasation of tumor cells. Unraveling the underlying molecular mechanisms might pinpoint to novel therapeutic options. To better understand these mechanisms it is crucial to identify targets of miR-200c. Here, we employ a combination of quantitative proteomic and bioinformatic strategies to identify novel miR-200c targets. We identify and confirm two subunits of the central cellular kinase protein kinase A (PKA), namely PRKAR1A and PRKACB, to be directly regulated by miR-200c. Notably, siRNA-mediated downregulation of both proteins phenocopies the migratory behavior of breast cancer cells after miR-200c overexpression. Patient data from publicly accessible databases supports a miR-200c-PKA axis. Thus, our study identifies the PKA heteroprotein as an important mediator of miR-200c induced repression of migration in breast cancer cells. By bioinformatics, we define a miRNA target cluster consisting of PRKAR1A, PRKAR2B, PRKACB, and COF2, which is targeted by a group of 14 miRNAs. PMID:26203557

  8. MiR-200c promotes bladder cancer cell migration and invasion by directly targeting RECK

    PubMed Central

    Cheng, Yidong; Zhang, Xiaolei; Li, Peng; Yang, Chengdi; Tang, Jinyuan; Deng, Xiaheng; Yang, Xiao; Tao, Jun; Lu, Qiang; Li, Pengchao

    2016-01-01

    Background Increasing evidence suggests that the dysregulation of certain microRNAs plays an important role in tumorigenesis and metastasis. MiR-200c exhibits a disordered expression in many tumors and presents dual roles in bladder cancer (BC). Therefore, the definite role of miR-200c in BC needs to be investigated further. Materials and methods Quantitative reverse transcription polymerase chain reaction was used to assess miR-200c expression. Cell invasion and migration were evaluated using wound healing and transwell assays. The luciferase reporter assay was used to identify the direct target of miR-200c. The expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK) in BC tissues and adjacent nontumor tissues, as well as in BC cell lines, was detected through quantitative reverse transcription polymerase chain reaction, Western blot assay, and immunohistochemistry. Results The miR-200c expression was significantly upregulated in the BC tissues compared with the adjacent nontumor tissues. The downregulation of miR-200c significantly inhibited cell migration and invasion in the BC cell lines. The luciferase reporter assay showed that RECK was a direct target of miR-200c. The knockdown of RECK in the BC cell lines treated with anti-miR-200c elevated the previously attenuated cell migration and invasion. Conclusion Our findings indicated that miR-200c functions as oncogenes in BC and may provide a novel therapeutic strategy for the treatment of BC. PMID:27574450

  9. A Comprehensive Review on miR-200c, A Promising Cancer Biomarker with Therapeutic Potential.

    PubMed

    Kumar, Suresh; Nag, Alo; Mandal, Chandi C

    2015-01-01

    MicroRNAs (miRNAs) are small single stranded non coding RNA molecules (~22 nucleotides) which impede protein production by directly interacting with 3'untranslated regions of the target mRNAs. Interestingly, miR-200c is often dysregulated in various cancers that normally exhibits tumor suppressive behavior by blocking epithelial to mesenchymal transition (EMT) of cancer cells. However, elevation of miR-200c in various cancer tissues contradicts the tumor suppressive role of this microRNA. This review addresses the molecular mechanisms involved in the regulation of the endogenous level of miR-200c in various cancers such as breast, ovarian, prostate, endometrial, lungs, colon, pancreatic, etc. and its differential role in regulation of proliferation and EMT phenotype of cancer cells. Further, this review discusses whether abnormal level of miR-200c in cancer tissues or in blood circulation can be used as a biomarker. Importantly, how the level of miR-200c can be used to predict the effectiveness of the cancer therapy is also discussed. Accumulating evidences suggest that use of miR-200c alone may not be sufficient for treatment of cancer patients, but the combination of miR-200c with an anti-proliferating drug could be a better choice to prevent invasiveness of cancers as well as tumor growth both in primary and in metastatic sites. This article also proposes that the tumor microenvironment may have a role in influencing epigenetic silencing of miR-200c expression.

  10. Therapeutic Delivery of miR-200c Enhances Radiosensitivity in Lung Cancer

    PubMed Central

    Cortez, Maria Angelica; Valdecanas, David; Zhang, Xiaochun; Zhan, Yanai; Bhardwaj, Vikas; Calin, George A; Komaki, Ritsuko; Giri, Dipak K; Quini, Caio C; Wolfe, Tatiana; Peltier, Heidi J; Bader, Andreas G; Heymach, John V; Meyn, Raymond E; Welsh, James W

    2014-01-01

    The microRNA (miR)-200s and their negative regulator ZEB1 have been extensively studied in the context of the epithelial–mesenchymal transition. Loss of miR-200s has been shown to enhance cancer aggressiveness and metastasis, whereas replacement of miR-200 miRNAs has been shown to inhibit cell growth in several types of tumors, including lung cancer. Here, we reveal a novel function of miR-200c, a member of the miR-200 family, in regulating intracellular reactive oxygen species signaling and explore a potential application for its use in combination with therapies known to increase oxidative stress such as radiation. We found that miR-200c overexpression increased cellular radiosensitivity by direct regulation of the oxidative stress response genes PRDX2, GAPB/Nrf2, and SESN1 in ways that inhibits DNA double-strand breaks repair, increase levels of reactive oxygen species, and upregulate p21. We used a lung cancer xenograft model to further demonstrate the therapeutic potential of systemic delivery of miR-200c to enhance radiosensitivity in lung cancer. Our findings suggest that the antitumor effects of miR-200c result partially from its regulation of the oxidative stress response; they further suggest that miR-200c, in combination with radiation, could represent a therapeutic strategy in the future. PMID:24791940

  11. Development of a 1 kW, 200 C Mapham Inventor

    NASA Technical Reports Server (NTRS)

    Hammoud, Ahmad; Gerber, Scott; Bauman, Eric; Overton, Eric; Myers, Ira; Bercaw, Robert

    1995-01-01

    Electronic systems and components are often exposed to high temperature environment in space-based applications, nuclear power facilities, and geothermal energy extraction fields. A key requirement for these systems is, therefore, to withstand the high temperature exposure while maintaining efficient and reliable operation. Efforts were taken to design and develop a high temperature power inverter capable of 200 C operation. A 1 kW, 20 kHz Mapham inverter was designed and evaluated as a function of temperature at different load levels. The inverter system, excluding its input, control, and logic circuits, was characterized at temperatures from ambient to 200 C at 0%, 50%, and 100% resistive loading. With an applied input voltage of 75 VDC, the inverter produced an output of 250 VAC. The results obtained, which indicate good operational characteristics of the inverter up to 200 C, are presented and discussed.

  12. Regulation of miR-200c by nuclear receptors PPAR{alpha}, LRH-1 and SHP

    SciTech Connect

    Zhang, Yuxia; Yang, Zhihong; Whitby, Richard; Wang, Li

    2011-12-09

    Highlights: Black-Right-Pointing-Pointer Knockdown of PPAR{alpha} and LRH-1 abolishes miR-200c inhibition of HCC cell migration. Black-Right-Pointing-Pointer SHP represses miR-200c expression via inhibition of the activity of PPAR{alpha} and LRH-1. Black-Right-Pointing-Pointer RJW100 exhibits strong ability to downregulate ZEB1 and ZEB2 proteins. -- Abstract: We investigated regulation of miR-200c expression by nuclear receptors. Ectopic expression of miR-200c inhibited MHCC97H cell migration, which was abrogated by the synergistic effects of PPAR{alpha} and LRH-1 siRNAs. The expression of miR-200c was decreased by PPAR{alpha}/LRH-1 siRNAs and increased by SHP siRNAs, and overexpression of the receptors reversed the effects of their respective siRNAs. SHP siRNAs also drastically enhanced the ability of the LRH-1 agonist RJW100 to induce miR-200c and downregulate ZEB1 and ZEB2 proteins. Co-expression of PPAR{alpha} and LRH-1 moderately transactivated the miR-200c promoter, which was repressed by SHP co-expression. RJW100 caused strong activation of the miR-200c promoter. This is the first report to demonstrate that miR-200c expression is controlled by nuclear receptors.

  13. miR-200c regulates FGFR-dependent epithelial proliferation via Vldlr during submandibular gland branching morphogenesis

    PubMed Central

    Rebustini, Ivan T.; Hayashi, Toru; Reynolds, Andrew D.; Dillard, Melvin L.; Carpenter, Ellen M.; Hoffman, Matthew P.

    2012-01-01

    The regulation of epithelial proliferation during organ morphogenesis is crucial for normal development, as dysregulation is associated with tumor formation. Non-coding microRNAs (miRNAs), such as miR-200c, are post-transcriptional regulators of genes involved in cancer. However, the role of miR-200c during normal development is unknown. We screened miRNAs expressed in the mouse developing submandibular gland (SMG) and found that miR-200c accumulates in the epithelial end buds. Using both loss- and gain-of-function, we demonstrated that miR-200c reduces epithelial proliferation during SMG morphogenesis. To identify the mechanism, we predicted miR-200c target genes and confirmed their expression during SMG development. We discovered that miR-200c targets the very low density lipoprotein receptor (Vldlr) and its ligand reelin, which unexpectedly regulate FGFR-dependent epithelial proliferation. Thus, we demonstrate that miR-200c influences FGFR-mediated epithelial proliferation during branching morphogenesis via a Vldlr-dependent mechanism. miR-200c and Vldlr may be novel targets for controlling epithelial morphogenesis during glandular repair or regeneration. PMID:22115756

  14. The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation

    PubMed Central

    Cao, Huojun; Jheon, Andrew; Li, Xiao; Sun, Zhao; Wang, Jianbo; Florez, Sergio; Zhang, Zichao; McManus, Michael T.; Klein, Ophir D.; Amendt, Brad A.

    2013-01-01

    The mouse incisor is a remarkable tooth that grows throughout the animal’s lifetime. This continuous renewal is fueled by adult epithelial stem cells that give rise to ameloblasts, which generate enamel, and little is known about the function of microRNAs in this process. Here, we describe the role of a novel Pitx2:miR-200c/141:noggin regulatory pathway in dental epithelial cell differentiation. miR-200c repressed noggin, an antagonist of Bmp signaling. Pitx2 expression caused an upregulation of miR-200c and chromatin immunoprecipitation assays revealed endogenous Pitx2 binding to the miR-200c/141 promoter. A positive-feedback loop was discovered between miR-200c and Bmp signaling. miR-200c/141 induced expression of E-cadherin and the dental epithelial cell differentiation marker amelogenin. In addition, miR-203 expression was activated by endogenous Pitx2 and targeted the Bmp antagonist Bmper to further regulate Bmp signaling. miR-200c/141 knockout mice showed defects in enamel formation, with decreased E-cadherin and amelogenin expression and increased noggin expression. Our in vivo and in vitro studies reveal a multistep transcriptional program involving the Pitx2:miR-200c/141:noggin regulatory pathway that is important in epithelial cell differentiation and tooth development. PMID:23863486

  15. Switching Characteristics of a 4H-SiC Based Bipolar Junction Transistor to 200 C

    NASA Technical Reports Server (NTRS)

    Niedra, Janis M.

    2006-01-01

    Static curves and resistive load switching characteristics of a 600 V, 4 A rated, SiC-based NPN bipolar power transistor (BJT) were observed at selected temperatures from room to 200 C. All testing was done in a pulse mode at low duty cycle (approx.0.1 percent). Turn-on was driven by an adjustable base current pulse and turn-off was accelerated by a negative base voltage pulse of 7 V. These base drive signals were implemented by 850 V, gated power pulsers, having rise-times of roughly 10 ns, or less. Base charge sweep-out with a 7 V negative pulse did not produce the large reverse base current pulse seen in a comparably rated Si-based BJT. This may be due to a very low charge storage time. The decay of the collector current was more linear than its exponential-like rise. Switching observations were done at base drive currents (I(sub B)) up to 400 mA and collector currents (I(sub C)) up to 4 A, using a 100 Omega non-inductive load. At I(sub B) = 400 mA and I(sub C) = 4 A, turn-on times typically varied from 80 to 94 ns, over temperatures from 23 to 200 C. As expected, lowering the base drive greatly extended the turn-on time. Similarly, decreasing the load current to I(sub C) = 1 A with I(sub B) = 400 mA produced turn-on times as short as 34 ns. Over the 23 to 200 C range, with I(sub B) = 400 mA and I(sub C) = 4 A, turn-off times were in the range of 72 to 84 ns with the 7 V sweep-out.

  16. A 200 C Universal Gate Driver Integrated Circuit for Extreme Environment Applications

    SciTech Connect

    Tolbert, Leon M; Huque, Mohammad A; Islam, Syed K; Blalock, Benjamin J

    2012-01-01

    High-temperature power converters (dc-dc, dc-ac, etc.) have enormous potential in extreme environment applications, including automotive, aerospace, geothermal, nuclear, and well logging. For successful realization of such high-temperature power conversion modules, the associated control electronics also need to perform at high temperature. This paper presents a silicon-on-insulator (SOI) based high-temperature gate driver integrated circuit (IC) incorporating an on-chip low-power temperature sensor and demonstrating an improved peak output current drive over our previously reported work. This driver IC has been primarily designed for automotive applications, where the underhood temperature can reach 200 C. This new gate driver prototype has been designed and implemented in a 0.8 {micro}m, 2-poly, and 3-metal bipolar CMOS-DMOS (Double-Diffused Metal-Oxide Semiconductor) on SOI process and has been successfully tested for up to 200 C ambient temperature driving a SiC MOSFET and a SiC normally-ON JFET. The salient feature of the proposed universal gate driver is its ability to drive power switches over a wide range of gate turn-ON voltages such as MOSFET (0 to 20 V), normally-OFF JFET (-7 to 3 V), and normally-ON JFET (-20 to 0 V). The measured peak output current capability of the driver is around 5 A and is thus capable of driving several power switches connected in parallel. An ultralow-power on-chip temperature supervisory circuit has also been integrated into the die to safeguard the driver circuit against excessive die temperature ({ge}220 C). This approach utilizes increased diode leakage current at higher temperature to monitor the die temperature. The power consumption of the proposed temperature sensor circuit is below 10 {micro}W for operating temperature up to 200 C.

  17. Clinical management of idiopathic epilepsy in dogs with homeopathic Belladonna 200C: a case series.

    PubMed

    Varshney, J P

    2007-01-01

    Epilepsy is an important neurological disorder in dogs. Belladonna 200C was evaluated in 10 dogs with idiopathic epilepsy. During the seizure phase, 3-4 drops of Belladonna 200C were administered orally at 15 min intervals until considerable reduction in seizure activity, then four times daily. Four dogs with head shaking syndrome in addition to seizures were given Cocculus 6C, 3-4 drops orally weekly for 3 months in addition. Numbers of fits reduced to 2-3 during first 2 weeks post-therapy and then became occasional in next 2 weeks. With continuation of Belladonna therapy, no fits were observed during 2-7 months follow-up. In two cases epileptic fits reappeared within 15-25 days of cessation of therapy. Belladonna therapy was resumed and seizure control was again achieved. Owners were advised to continue the therapy at least twice daily until there were no fits for 2-3 months. Liver specific enzymes were monitored, no abnormalities were observed.

  18. MiR-200c inhibits autophagy and enhances radiosensitivity in breast cancer cells by targeting UBQLN1.

    PubMed

    Sun, Quanquan; Liu, Tongxin; Yuan, Yawei; Guo, Zhenli; Xie, Guozhu; Du, Shasha; Lin, Xiaoshan; Xu, Zhixin; Liu, Minfeng; Wang, Wei; Yuan, Quan; Chen, Longhua

    2015-03-01

    Radioresistance is a major challenge during the treatment of breast cancer. A further understanding of the mechanisms of radioresistance could provide strategies to address this challenge. In our study, we compared the expression of miR-200c in four distinct breast cancer cell lines: two representative basal cancer cells (MDA-MB-231 and BT549) vs. two representative luminal cancer cells (MCF-7 and BT474). The results revealed practically lower expression of miR-200c in the two basal cancer cell lines and higher expression of miR-200c in luminal cancer cells compared to the normal breast epithelial cell line MCF-10A. Ectopic expression of miR-200c in MDA-MB-231 cells inhibited irradiation-induced autophagy and sensitized the breast cancer cells to irradiation. We also identified UBQLN1 as a direct functional target of miR-200c involved in irradiation-induced autophagy and radioresistance. In 35 human breast cancer tissue samples, we detected an inverse correlation between the expression of miR-200c vs. UBQLN1 and LC3. These results indicate that the identified miR-200c/UBQLN1-mediated autophagy pathway may help to elucidate radioresistance in human breast cancer and might represent a therapeutic strategy.

  19. MicroRNA-200c Represses IL-6, IL-8, and CCL-5 Expression and Enhances Osteogenic Differentiation.

    PubMed

    Hong, Liu; Sharp, Thad; Khorsand, Behnoush; Fischer, Carol; Eliason, Steven; Salem, Ali; Akkouch, Adil; Brogden, Kim; Amendt, Brad A

    2016-01-01

    MicroRNAs (miRs) regulate inflammation and BMP antagonists, thus they have potential uses as therapeutic reagents. However, the molecular function of miR-200c in modulating proinflammatory and bone metabolic mediators and osteogenic differentiation is not known. After miR-200c was transduced into a human embryonic palatal mesenchyme (HEPM) (a cell line of preosteoblasts), using lentiviral vectors, the resulting miR-200c overexpression increased osteogenic differentiation biomarkers, including osteocalcin (OCN) transcripts and calcium content. miR-200c expression also down-regulated interleukin (IL)-6, IL-8, and chemokine (C-C motif) ligand (CCL)-5 under lipopolysaccharide (LPS) stimulation and increased osteoprotegerin (OPG) in these cells. miR-200c directly regulates the expression of IL-6, IL-8 and CCL-5 transcripts by binding to their 3'UTRs. A plasmid-based miR-200c inhibitor effectively reduces their binding activities. Additionally, miR-200c delivered using polyethylenimine (PEI) nanoparticles effectively inhibits IL-6, IL-8 and CCL-5 in primary human periodontal ligament fibroblasts and increases the biomarkers of osteogenic differentiation in human bone marrow mesenchymal stem cells (MSCs), including calcium content, ALP, and Runx2. These data demonstrate that miR-200c represses IL-6, IL-8 and CCL-5 and improves osteogenic differentiation. miR-200c may potentially be used as an effective means to prevent periodontitis-associated bone loss by arresting inflammation and osteoclastogenesis and enhancing bone regeneration. PMID:27529418

  20. MicroRNA-200c Represses IL-6, IL-8, and CCL-5 Expression and Enhances Osteogenic Differentiation

    PubMed Central

    Sharp, Thad; Khorsand, Behnoush; Fischer, Carol; Eliason, Steven; Salem, Ali; Akkouch, Adil; Brogden, Kim; Amendt, Brad A.

    2016-01-01

    MicroRNAs (miRs) regulate inflammation and BMP antagonists, thus they have potential uses as therapeutic reagents. However, the molecular function of miR-200c in modulating proinflammatory and bone metabolic mediators and osteogenic differentiation is not known. After miR-200c was transduced into a human embryonic palatal mesenchyme (HEPM) (a cell line of preosteoblasts), using lentiviral vectors, the resulting miR-200c overexpression increased osteogenic differentiation biomarkers, including osteocalcin (OCN) transcripts and calcium content. miR-200c expression also down-regulated interleukin (IL)-6, IL-8, and chemokine (C-C motif) ligand (CCL)-5 under lipopolysaccharide (LPS) stimulation and increased osteoprotegerin (OPG) in these cells. miR-200c directly regulates the expression of IL-6, IL-8 and CCL-5 transcripts by binding to their 3’UTRs. A plasmid-based miR-200c inhibitor effectively reduces their binding activities. Additionally, miR-200c delivered using polyethylenimine (PEI) nanoparticles effectively inhibits IL-6, IL-8 and CCL-5 in primary human periodontal ligament fibroblasts and increases the biomarkers of osteogenic differentiation in human bone marrow mesenchymal stem cells (MSCs), including calcium content, ALP, and Runx2. These data demonstrate that miR-200c represses IL-6, IL-8 and CCL-5 and improves osteogenic differentiation. miR-200c may potentially be used as an effective means to prevent periodontitis-associated bone loss by arresting inflammation and osteoclastogenesis and enhancing bone regeneration. PMID:27529418

  1. Static and Switching Characteristics of a 4H-SiC Based BJT to 200 C

    NASA Technical Reports Server (NTRS)

    Niedra, Janis M.; Schwarze, Gene E.

    2006-01-01

    Static curves and resistive load switching characteristics of a 600 V, 4 A rated, SiC-based NPN bipolar power transistor (BJT) were observed at selected temperatures from 23 to 200 C. All testing was done in a pulse mode at low duty cycle (approx. 0.1 percent). Turn-on was driven by an adjustable base current pulse and turn-off was accelerated by a negative base voltage pulse of either 7 or 0.6 V. Switching observations were done at base drive currents (I(sub B)) up to 400 mA and collector currents (I(sub C)) up to 4 A, using a 100 OMEGA non-inductive load. At I(sub B) = 400 mA and I(sub C) = 4 A, turn-on times typically varied from 81 to 97 ns, over temperatures from 23 to 200 C. As expected, lowering the base drive greatly extended the turn-on time. Similarly, decreasing the load current to I(sub C) = 1 A with I(sub B) = 400 mA produced turn-on times as short as 30 ns. Over the 23 to 200 C range, with I(sub B) = 400 mA and I(sub C) = 4 A, turn-off times were in the range of 61 to 77 ns with the 7 V sweep-out and 130 to 150 ns with the 0.6 V sweep-out. At a fixed temperature and I(sub C), the turn-off time decreased slightly with decreasing I(sub B), for I(sub B) sufficient to still provide full turn-on. The ratio of conduction to switching losses is estimated, based on the observed I(sub C) transition times and static curves. An estimate at 200 kHz and a 50 percent duty cycle shows that under practicable conditions the two losses can be comparable. Hence the evidence obtained does not support the occasionally voiced concern of necessarily unacceptably high conduction losses in SiC-based BJTs.

  2. Nuclear Melt Glass Dissolution and Secondary Mineral Precipitation at 40 to 200C

    SciTech Connect

    Zavarin, M; Roberts, S; Viani, B; Pawloski, G; Rose, T

    2004-06-14

    Most long-lived radionuclides associated with an underground nuclear test are initially incorporated into melt glass and become part of the hydrologic source term (HST) only upon their release via glass dissolution (Pawloski et al., 2001). As the melt glass dissolves, secondary minerals precipitate. The types of secondary minerals that precipitate influence the water chemistry in and around the melt glass. The secondary minerals also provide a sorption sink to the released radionuclides. The changing water chemistry affects the rate of glass dissolution; it also affects the sorption behavior of the released radionuclides. This complex nature of glass dissolution and its important role in defining the HST requires a thorough understanding of glass dissolution and secondary mineral precipitation. The identity of secondary minerals formed at temperatures from 40 to 200 C are evaluated in this report to assist in that understanding.

  3. miR-200c and GATA binding protein 4 regulate human embryonic stem cell renewal and differentiation.

    PubMed

    Huang, Hsiao-Ning; Chen, Shao-Yin; Hwang, Shiaw-Min; Yu, Ching-Chia; Su, Ming-Wei; Mai, Wei; Wang, Hsei-Wei; Cheng, Wei-Chung; Schuyler, Scott C; Ma, Nianhan; Lu, Frank Leigh; Lu, Jean

    2014-03-01

    Human embryonic stem cells (hESCs) are functionally unique for their self-renewal ability and pluripotency, but the molecular mechanisms giving rise to these properties are not fully understood. hESCs can differentiate into embryoid bodies (EBs) containing ectoderm, mesoderm, and endoderm. In the miR-200 family, miR-200c was especially enriched in undifferentiated hESCs and significantly downregulated in EBs. The knockdown of the miR-200c in hESCs downregulated Nanog expression, upregulated GATA binding protein 4 (GATA4) expression, and induced hESC apoptosis. The knockdown of GATA4 rescued hESC apoptosis induced by downregulation of miR-200c. miR-200c directly targeted the 3'-untranslated region of GATA4. Interestingly, the downregulation of GATA4 significantly inhibited EB formation in hESCs. Overexpression of miR-200c inhibited EB formation and repressed the expression of ectoderm, endoderm, and mesoderm markers, which could partially be rescued by ectopic expression of GATA4. Fibroblast growth factor (FGF) and activin A/nodal can sustain hESC renewal in the absence of feeder layer. Inhibition of transforming growth factor-β (TGF-β[Symbol: see text])/activin A/nodal signaling by SB431542 treatment downregulated the expression of miR-200c. Overexpression of miR-200c partially rescued the expression of Nanog/phospho-Smad2 that was downregulated by SB431542 treatment. Our observations have uncovered novel functions of miR-200c and GATA4 in regulating hESC renewal and differentiation.

  4. Physics 200, 300 Interim Guide.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg.

    This guide, developed for the physics 200, 300 program in Manitoba, is designed to articulate with previous science courses; provide concepts, processes, and skills which will enable students to continue in physics-related areas; and relate physics to practical applications in everyday life. It includes a program overview (with program goals and…

  5. Chemistry 200, 300 Interim Guide.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education, Winnipeg.

    This guide, developed for the chemistry 200, 300 program in Manitoba, is designed to articulate with previous science courses, provide concepts, processes, and skills which will enable students to continue in chemistry-related areas, and relate chemistry to practical applications in everyday life. It includes a program overview (with program goals…

  6. Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells

    SciTech Connect

    Vrba, Lukas; Jensen, Taylor J.; Garbe, James C.; Heimark, Ronald L.; Cress, Anne E.; Dickinson, Sally; Stampfer, Martha R.; Futscher, Bernard W.

    2009-12-23

    BACKGROUND: The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal transition (EMT). Furthermore, the loss of expression of miR-200 family members is linked to an aggressive cancer phenotype. Regulation of the miR-200 family expression in normal and cancer cells is not fully understood. METHODOLOGY/ PRINCIPAL FINDINGS: Epigenetic mechanisms participate in the control of miR-200c and miR-141 expression in both normal and cancer cells. A CpG island near the predicted mir-200c/mir-141 transcription start site shows a striking correlation between miR-200c and miR-141 expression and DNA methylation in both normal and cancer cells, as determined by MassARRAY technology. The CpG island is unmethylated in human miR-200/miR-141 expressing epithelial cells and in miR-200c/miR-141 positive tumor cells. The CpG island is heavily methylated in human miR-200c/miR-141 negative fibroblasts and miR-200c/miR-141 negative tumor cells. Mouse cells show a similar inverse correlation between DNA methylation and miR-200c expression. Enrichment of permissive histone modifications, H3 acetylation and H3K4 trimethylation, is seen in normal miR-200c/miR-141-positive epithelial cells, as determined by chromatin immunoprecipitation coupled to real-time PCR. In contrast, repressive H3K9 dimethylation marks are present in normal miR-200c/miR-141-negative fibroblasts and miR-200c/miR-141 negative cancer cells and the permissive histone modifications are absent. The epigenetic modifier drug, 5-aza-2'-deoxycytidine, reactivates miR-200c/miR-141 expression showing that epigenetic mechanisms play a functional role in their transcriptional control. CONCLUSIONS/ SIGNIFICANCE: We report that DNA methylation plays a role in the normal cell type-specific expression of miR-200c and miR-141 and this role appears evolutionarily conserved, since similar results were obtained in mouse. Aberrant DNA methylation of the

  7. miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

    PubMed Central

    Sulaiman, Siti A.; Ab Mutalib, Nurul-Syakima; Jamal, Rahman

    2016-01-01

    Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are single-stranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelial-to-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed.

  8. miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition.

    PubMed

    Sulaiman, Siti A; Ab Mutalib, Nurul-Syakima; Jamal, Rahman

    2016-01-01

    Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are single-stranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelial-to-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed.

  9. miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition

    PubMed Central

    Sulaiman, Siti A.; Ab Mutalib, Nurul-Syakima; Jamal, Rahman

    2016-01-01

    Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are single-stranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelial-to-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed. PMID:27601996

  10. miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition.

    PubMed

    Sulaiman, Siti A; Ab Mutalib, Nurul-Syakima; Jamal, Rahman

    2016-01-01

    Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are single-stranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelial-to-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed. PMID:27601996

  11. Electroneutral composite polymersomes self-assembled by amphiphilic polyphosphazenes for effective miR-200c in vivo delivery to inhibit drug resistant lung cancer.

    PubMed

    Peng, Yan; Zhu, Xiumei; Qiu, Liyan

    2016-11-01

    MiR-200c has been confirmed to display remarkable effects on proliferation inhibition and apoptosis induction of certain cancer cells, but the main challenge for its successful translation into the clinic remains its effective delivery to the action site in vivo. In this study, a novel composite polyphosphazene vesicle system composed of amphiphilic [NP(PEG)0.3(EAB)1.7]n (PEEP) and weakly cationic [NP(PEG)0.5(DPA)1.5]n (PEDP) was prepared via a very simple dialysis method. The loading of miR-200c was accomplished with high efficiency by taking advantage of the combination effect of physical encapsulation and electrostatic interaction between vectors and miR-200c. The resultant miR-200c-loaded PEEP-PEDP polymersome (Nano-ED-200c) displayed suitable particle size, electric neutrality, excellent Ribonuclease stability and hemocompatibility. We also evaluated its subsequent miR-200c function in paclitaxel resistance human lung cancer (A549/T) cells in culture and tumor xenografts in nude mice. The results showed that Nano-ED-200c could achieve a higher miR-200c level and the enhanced antitumor efficacy with 68% tumor inhibition ratio at a very low dose of 1.0 mg/kg than PEEP nanoparticle, PEDP nanoparticle, even than Lipo2000. All these evidences indicated that this miR-200c delivery via polyphosphazene vesicles could act as a potential new therapeutic option for paclitaxel resistant human lung cancer.

  12. Electroneutral composite polymersomes self-assembled by amphiphilic polyphosphazenes for effective miR-200c in vivo delivery to inhibit drug resistant lung cancer.

    PubMed

    Peng, Yan; Zhu, Xiumei; Qiu, Liyan

    2016-11-01

    MiR-200c has been confirmed to display remarkable effects on proliferation inhibition and apoptosis induction of certain cancer cells, but the main challenge for its successful translation into the clinic remains its effective delivery to the action site in vivo. In this study, a novel composite polyphosphazene vesicle system composed of amphiphilic [NP(PEG)0.3(EAB)1.7]n (PEEP) and weakly cationic [NP(PEG)0.5(DPA)1.5]n (PEDP) was prepared via a very simple dialysis method. The loading of miR-200c was accomplished with high efficiency by taking advantage of the combination effect of physical encapsulation and electrostatic interaction between vectors and miR-200c. The resultant miR-200c-loaded PEEP-PEDP polymersome (Nano-ED-200c) displayed suitable particle size, electric neutrality, excellent Ribonuclease stability and hemocompatibility. We also evaluated its subsequent miR-200c function in paclitaxel resistance human lung cancer (A549/T) cells in culture and tumor xenografts in nude mice. The results showed that Nano-ED-200c could achieve a higher miR-200c level and the enhanced antitumor efficacy with 68% tumor inhibition ratio at a very low dose of 1.0 mg/kg than PEEP nanoparticle, PEDP nanoparticle, even than Lipo2000. All these evidences indicated that this miR-200c delivery via polyphosphazene vesicles could act as a potential new therapeutic option for paclitaxel resistant human lung cancer. PMID:27541441

  13. The electrolyte challenge for a direct methanol-air polymer electrolyte fuel cell operating at temperatures up to 200 C

    NASA Technical Reports Server (NTRS)

    Savinell, Robert; Yeager, Ernest; Tryk, Donald; Landau, Uziel; Wainright, Jesse; Gervasio, Dominic; Cahan, Boris; Litt, Morton; Rogers, Charles; Scherson, Daniel

    1993-01-01

    Novel polymer electrolytes are being evaluated for use in a direct methanol-air fuel cell operating at temperatures in excess of 100 C. The evaluation includes tests of thermal stability, ionic conductivity, and vapor transport characteristics. The preliminary results obtained to date indicate that a high temperature polymer electrolyte fuel cell is feasible. For example, Nafion 117 when equilibrated with phosphoric acid has a conductivity of at least 0.4 Omega(exp -1)cm(exp -1) at temperatures up to 200 C in the presence of 400 torr of water vapor and methanol vapor cross over equivalent to 1 mA/cm(exp 2) under a one atmosphere methanol pressure differential at 135 C. Novel polymers are also showing similar encouraging results. The flexibility to modify and optimize the properties by custom synthesis of these novel polymers presents an exciting opportunity to develop an efficient and compact methanol fuel cell.

  14. Diagnostic and prognostic relevance of circulating exosomal miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer

    PubMed Central

    Meng, Xiaodan; Müller, Volkmar; Milde-Langosch, Karin; Trillsch, Fabian; Pantel, Klaus; Schwarzenbach, Heidi

    2016-01-01

    Exosomes are membrane vesicles that mediate intercellular communication by transporting their molecular cargo from cell to cell. We investigated whether serum levels of exosomal miR-373, miR-200a, miR-200b and miR-200c and circulating exosomes have diagnostic and prognostic relevance in a cohort of 163 epithelial ovarian cancer (EOC) patients using TaqMan MicroRNA assays and ELISA. The serum concentrations of exosomal miR-373 (p = 0.0001), miR-200a (p = 0.0001), miR-200b (p = 0.0001) and miR-200c (p = 0.028) were significantly higher in EOC patients than healthy women. The levels of miR-200a (p = 0.0001), miR-200b (p = 0.0001) and miR-200c (p = 0.019) could distinguish between malignant and benign ovarian tumors. While the levels of miR-373 and miR-200a were increased in all FIGO/lymph node stages (p = 0.0001), the levels of miR-200b and miR-200c were higher in patients with FIGO stage III–IV (p = 0.0001, p = 0.008, respectively) including lymph node metastasis (p = 0.0001, p = 0.004, respectively) than FIGO stages I–II. The increased levels of miR-200b and miR-200c were also associated with CA125 values (p = 0.0001, p = 0.0001, respectively) and a shorter overall survival (p = 0.007, p = 0.017, respectively). The levels of exosomes were excessively elevated in EOC patients (p = 0.0001). In all three cohorts, they were positively associated with the serum levels of exosomal miR-373 (p = 0.004), miR-200a (p = 0.0001), miR-200b (p = 0.0001) and miR-200c (p = 0.008). In conclusion, the increased levels of exosomal miR-200b and miR-200c mainly observed in advanced EOC suggest that these microRNAs may be involved in tumor progression. The high concentrations of exosomes in EOC patients imply an excessive, active exosomal secretion in EOC. PMID:26943577

  15. Diagnostic and prognostic relevance of circulating exosomal miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer.

    PubMed

    Meng, Xiaodan; Müller, Volkmar; Milde-Langosch, Karin; Trillsch, Fabian; Pantel, Klaus; Schwarzenbach, Heidi

    2016-03-29

    Exosomes are membrane vesicles that mediate intercellular communication by transporting their molecular cargo from cell to cell. We investigated whether serum levels of exosomal miR-373, miR-200a, miR-200b and miR-200c and circulating exosomes have diagnostic and prognostic relevance in a cohort of 163 epithelial ovarian cancer (EOC) patients using TaqMan MicroRNA assays and ELISA. The serum concentrations of exosomal miR-373 (p = 0.0001), miR-200a (p = 0.0001), miR-200b (p = 0.0001) and miR-200c (p = 0.028) were significantly higher in EOC patients than healthy women. The levels of miR-200a (p = 0.0001), miR-200b (p = 0.0001) and miR-200c (p = 0.019) could distinguish between malignant and benign ovarian tumors. While the levels of miR-373 and miR-200a were increased in all FIGO/lymph node stages (p = 0.0001), the levels of miR-200b and miR-200c were higher in patients with FIGO stage III-IV (p = 0.0001, p = 0.008, respectively) including lymph node metastasis (p = 0.0001, p = 0.004, respectively) than FIGO stages I-II. The increased levels of miR-200b and miR-200c were also associated with CA125 values (p = 0.0001, p = 0.0001, respectively) and a shorter overall survival (p = 0.007, p = 0.017, respectively). The levels of exosomes were excessively elevated in EOC patients (p = 0.0001). In all three cohorts, they were positively associated with the serum levels of exosomal miR-373 (p = 0.004), miR-200a (p = 0.0001), miR-200b (p = 0.0001) and miR-200c (p = 0.008). In conclusion, the increased levels of exosomal miR-200b and miR-200c mainly observed in advanced EOC suggest that these microRNAs may be involved in tumor progression. The high concentrations of exosomes in EOC patients imply an excessive, active exosomal secretion in EOC.

  16. Enhancement of radiotherapy efficacy by miR-200c-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer cells

    PubMed Central

    Cui, Fang-bo; Liu, Qin; Li, Ru-Tian; Shen, Jie; Wu, Pu-yuan; Yu, Li-Xia; Hu, Wen-jing; Wu, Feng-lei; Jiang, Chun-Ping; Yue, Guo-feng; Qian, Xiao-Ping; Jiang, Xi-Qun; Liu, Bao-Rui

    2014-01-01

    Radiotherapy is the main locoregional control modality for many types of unresectable tumors, including gastric cancer. However, many patients fail radiotherapy due to intrinsic radioresistance of cancer cells, which has been found to be strongly associated with cancer stem cell (CSC)-like properties. In this study, we developed a nanoparticle formulation to deliver miR-200c, which is reported to inhibit CSC-like properties, and then evaluated its potential activity as a radiosensitizer. miR-200c nanoparticles significantly augmented radiosensitivity in three gastric cancer cell lines (sensitization enhancement ratio 1.13–1.25), but only slightly in GES-1 cells (1.06). In addition to radioenhancement, miR-200c nanoparticles reduced the expression of CD44, a putative CSC marker, and the percentage of CD44+ BGC823 cells. Meanwhile, other CSC-like properties, including invasiveness and resistance to apoptosis, could be suppressed by miR-200c nanoparticles. CSC-associated radioresistance mechanisms, involving reactive oxygen species levels and DNA repair capacity, were also attenuated. We have demonstrated that miR-200c nanoparticles are an effective radiosensitizer in gastric cancer cells and induce little radiosensitization in normal cells, which suggests that they are as a promising candidate for further preclinical and clinical evaluation. PMID:24872697

  17. Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts.

    PubMed

    Zhu, Hua-Yu; Bai, Wen-Dong; Li, Chao; Zheng, Zhao; Guan, Hao; Liu, Jia-Qi; Yang, Xue-Kang; Han, Shi-Chao; Gao, Jian-Xin; Wang, Hong-Tao; Hu, Da-Hai

    2016-01-01

    Abnormally high activation of transforming growth factor-β (TGF-β) signaling has been demonstrated to be involved in the initiation and progression of keloids. However, the functional role of long non-coding RNA (lncRNA)-activated by TGF-β (lncRNA-ATB) in keloids has not been documented. Here we investigated the role of lncRNA-ATB in the autocrine secretion of TGF-β in keloid fibroblasts (KFs) and explored the underlying molecular mechanism. Using immunohistochemistry and quantitative RT-PCR analysis, we showed that lncRNA-ATB and ZNF217, a transcriptional activator of TGF-β, were overexpressed and miR-200c, which targets ZNF217, was under-expressed in keloid tissue and keloid fibroblasts. Through gain- and loss-of-function studies, we demonstrated that knockdown of lncRNA-ATB decreased autocrine secretion of TGF-β2 and ZNF217 expression but upregulated expression of miR-200c in KFs. Stable downregulation of ZNF217 expression decreased the autocrine secretion of TGF-β2. miR-200c was endogenously associated with lncRNA-ATB, and inhibition of miR-200c overcame the decrease in ZNF217 expression in KFs. Taken together, these findings indicate that lncRNA-ATB governs the autocrine secretion of TGF-β2 in KFs, at least in part, by downregulating the expression level of ZNF217 via miR-200c, suggesting a signaling axis consisting of lncRNA-ATB/miR-200c/ZNF217/TGF-β2. These findings may provide potential biomarkers and targets for novel diagnostic and therapeutic approaches for keloids. PMID:27090737

  18. 40 CFR 300.200 - General.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Planning and Preparedness § 300.200 General. This subpart summarizes emergency preparedness activities...

  19. 40 CFR 300.200 - General.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Planning and Preparedness § 300.200 General. This subpart summarizes emergency preparedness activities...

  20. 40 CFR 300.200 - General.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Planning and Preparedness § 300.200 General. This subpart summarizes emergency preparedness activities...

  1. 40 CFR 300.200 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Planning and Preparedness § 300.200 General. This subpart summarizes emergency preparedness activities...

  2. 40 CFR 300.200 - General.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND COMMUNITY RIGHT-TO-KNOW PROGRAMS NATIONAL OIL AND HAZARDOUS SUBSTANCES POLLUTION CONTINGENCY PLAN Planning and Preparedness § 300.200 General. This subpart summarizes emergency preparedness activities...

  3. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false How is the âdeficient in basic literacy... INVESTMENT ACT Eligibility for Youth Services § 664.205 How is the “deficient in basic literacy skills... requirements regarding the “deficient in basic literacy skills” criterion in § 664.200(c)(1) may be...

  4. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 4 2012-04-01 2012-04-01 false How is the âdeficient in basic literacy... WORKFORCE INVESTMENT ACT Eligibility for Youth Services § 664.205 How is the “deficient in basic literacy... documentation requirements regarding the “deficient in basic literacy skills” criterion in § 664.200(c)(1)...

  5. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 4 2014-04-01 2014-04-01 false How is the âdeficient in basic literacy... WORKFORCE INVESTMENT ACT Eligibility for Youth Services § 664.205 How is the “deficient in basic literacy... documentation requirements regarding the “deficient in basic literacy skills” criterion in § 664.200(c)(1)...

  6. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false How is the âdeficient in basic literacy... INVESTMENT ACT Eligibility for Youth Services § 664.205 How is the “deficient in basic literacy skills... requirements regarding the “deficient in basic literacy skills” criterion in § 664.200(c)(1) may be...

  7. 20 CFR 664.205 - How is the “deficient in basic literacy skills” criterion in § 664.200(c)(1) defined and documented?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 4 2013-04-01 2013-04-01 false How is the âdeficient in basic literacy... WORKFORCE INVESTMENT ACT Eligibility for Youth Services § 664.205 How is the “deficient in basic literacy... documentation requirements regarding the “deficient in basic literacy skills” criterion in § 664.200(c)(1)...

  8. Hepatitis C Virus Induced miR200c Down Modulates FAP-1, a Negative Regulator of Src Signaling and Promotes Hepatic Fibrosis

    PubMed Central

    Ramachandran, Sabarinathan; Ilias Basha, Haseeb; Sarma, Nayan J.; Lin, Yiing; Crippin, Jeffrey S.; Chapman, William C.; Mohanakumar, Thalachallour

    2013-01-01

    Hepatitis C virus (HCV) induced liver disease is the leading indication for liver transplantation (LTx). Reinfection and accelerated development of fibrosis is a universal phenomenon following LTx. The molecular events that lead to fibrosis following HCV infection still remains poorly defined. In this study, we determined microRNA (miRNA) and mRNA expression profiles in livers from chronic HCV patients and normals using microarrays. Using Genego software and pathway finder we performed an interactive analysis to identify target genes that are modulated by miRNAs. 22 miRNAs were up regulated (>2 fold) and 35 miRNAs were down regulated (>2fold) compared to controls. Liver from HCV patients demonstrated increased expression of 306 genes (>3 fold) and reduced expression of 133 genes (>3 fold). Combinatorial analysis of the networks modulated by the miRNAs identified regulation of the phospholipase C pathway (miR200c, miR20b, and miR31through cellular proto-oncogene tyrosine-protein kinase Src (cSrc)), response to growth factors and hormones (miR141, miR107 and miR200c through peroxisome proliferator-activated receptor alpha and extracellular-signal-regulated kinases, and regulation of cellular proliferation (miR20b, miR10b, and miR141 through cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 p21). Real time PCR (RT-PCR) validation of the miRNA in HCV infected livers demonstrated a 3.3 ±0.9 fold increase in miR200c. In vitro transfection of fibroblasts with miR200c resulted in a 2.2 fold reduction in expression of tyrosine-protein phosphatase non-receptor type 13 or FAS associated phosphatase 1 (FAP-1) and 2.3 fold increase in expression of cSrc. miR200c transfection resulted in significant increases in expression of collagen and fibroblast growth factor (2.8 and 3.4 fold, p<0.05). Therefore, we propose that HCV induced increased expression of miR200c can down modulate the expression of FAP1, a critical regulator of Src and MAP kinase pathway that play

  9. 50 CFR 300.200 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Definition of Illegal, Unreported, or Unregulated Fishing § 300.200 Purpose. The purpose of this subpart is... Reauthorization Act of 2006 (“Act”) to publish a definition of the term “Illegal, unreported, or...

  10. 75 FR 10658 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-09

    ... fuselage skin at certain lap joints, butt joints, external repair doublers, and other areas; and related... detailed analysis of fuselage skin cracks adjacent to the skin lap joints on airplanes that had scribe... airplane groupings. We are issuing this AD to prevent rapid decompression of the airplane due to...

  11. 76 FR 74667 - Airworthiness Directives; The Boeing Company Model 737-200, -200C, -300, -400, and -500 Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-01

    ... publication listed in this AD as of February 16, 2010 (75 FR 1527, January 12, 2010). ADDRESSES: For service... SW., Renton, Washington. For information on the availability of this material at the FAA, call (425... (NPRM) to amend 14 CFR part 39 to supersede AD 2010-01-09, Amendment 39-16167 (75 FR 1527, January...

  12. 76 FR 72858 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-28

    ... reports of cracking of the STA 348.2 frame above the two outboard fasteners attaching the frame inner chord and door stop fittings, and in the outboard chord at stringer S-16L. We have also received reports... the overall regulatory, economic, environmental, and energy aspects of this proposed AD. We...

  13. 75 FR 19564 - Airworthiness Directives; The Boeing Company Model 737-200, -200C, -300, -400, and- 500 Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-15

    ..., are necessary to comply with AD 90-06-02, Amendment 39-6489 (55 FR 8372, March 7, 1990). FAA's... Order 12866, 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR... surrounding structure under the number 3 very high frequency (VHF) antenna, and corrective actions...

  14. 76 FR 63229 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    .... ``CENTER WING (AND BOEING AUXILIARY) TANK FUEL PUMPS Intentional dry running of a center wing or auxiliary... appropriate FAA Principal Operations Inspector. ``CENTER WING (AND BOEING AUXILIARY) TANK FUEL PUMPS Center... to monitor low pressure lights. For ground operation, center wing (or auxiliary) tank fuel...

  15. 75 FR 43803 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-27

    ..., 2010. On December 4, 2003 (68 FR 67027, December 1, 2003), the Director of the Federal Register... include an AD that supersedes AD 2003-24-08, Amendment 39-13377 (68 FR 67027, December 1, 2003). The... published in the Federal Register on March 1, 2010 (75 FR 9137). That NPRM proposed to continue to...

  16. 75 FR 9137 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-01

    ... spindles, and to prevent severe flap asymmetry, which could result in reduced control or loss of... 5 p.m., Monday through Friday, except Federal holidays. For service information identified in this... other information. The street address for the Docket Office (telephone 800-647-5527) is in the...

  17. 75 FR 48620 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... November 7, 2003, we issued related AD 2003-03-15 R1, Amendment 39-13366 (68 FR 64802, November 17, 2003... June 15, 2006, we issued related AD 2006-13-13, Amendment 39- 14666 (71 FR 35781, June 22, 2006). (A correction of that AD was published in the Federal Register on July 3, 2006 (71 FR 37980).) That AD...

  18. 76 FR 6529 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... (75 FR 48620). That NPRM proposed to require installing two warning level indicator lights on the P2-2... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... the flightcrew due to hypoxia (lack of oxygen in body), and consequent loss of control of the...

  19. 76 FR 47522 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-05

    .... Discussion On June 5, 1995, we issued AD 95-12-17, amendment 39-9268 (60 FR 36981, July 19, 1995), for... a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26..., Amendment 39-9268 (60 FR 36981, July 19, 1995), and adding the following new AD: The Boeing Company:...

  20. 76 FR 3856 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-21

    ...'' (66 FR 23086, May 7, 2001). In addition to new airworthiness standards for transport airplanes and new... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... proposed AD would result in all airplanes having new relays with a ground fault interrupter (GFI)...

  1. 76 FR 33988 - Airworthiness Directives; The Boeing Company Model 737-100, -200, -200C, -300, -400, and -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... (76 FR 3856). That NPRM proposed to require, depending on airplane configuration, doing certain wiring... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034... applicable, with new relays having a ground fault interrupter (GFI) feature, performing certain...

  2. NF-κB-mediated inflammation leading to EMT via miR-200c is involved in cell transformation induced by cigarette smoke extract.

    PubMed

    Zhao, Yue; Xu, Yuan; Li, Yuan; Xu, Wenchao; Luo, Fei; Wang, Bairu; Pang, Ying; Xiang, Quanyong; Zhou, Jianwei; Wang, Xinru; Liu, Qizhan

    2013-10-01

    Cigarette smoking constitutes a major human health hazard because it is the most important risk factor for lung cancer. Although evidence for smoking-induced lung cancer in humans is strong, the molecular mechanisms by which smoking causes cancer remain to be established. In this investigation, we evaluated the roles of inflammation and the epithelial-mesenchymal transition (EMT) in cigarette smoke extract (CSE)-induced transformation of human bronchial epithelial (HBE) cells. The results showed that chronic exposure to CSE induced EMT and transformation of these cells. Activation of nuclear factor-κB (NF-κB) by CSE increased levels of the proinflammatory interleukin-6 (IL-6), and acute and chronic exposures to CSE caused decreases in miR-200c levels. By blocking NF-κB with Bay11-7082 and IL-6 with anti-IL-6 antibody and enhancement of IL-6 with human recombinant IL-6, we found that the NF-κB signal pathway was involved in CSE-induced increases of IL-6, which suppressed miR-200c expression and promoted EMT. Moreover, IL-6 was necessary for maintenance of CSE-induced transformation and for malignant progression of HBE cells. Finally, blocking of NF-κB with Bay11-7082 prevented CSE-induced EMT and malignant transformation due to decreases of E-cadherin and miR-200c and elevations of IL-6, N-cadherin, and vimentin. Thus, we have defined a link between inflammation and EMT, processes involved in the malignant transformation of cells caused by CSE. This link, mediated through miRNAs, establishes a mechanism for CSE-induced lung carcinogenesis.

  3. NF-κB-mediated inflammation leading to EMT via miR-200c is involved in cell transformation induced by cigarette smoke extract.

    PubMed

    Zhao, Yue; Xu, Yuan; Li, Yuan; Xu, Wenchao; Luo, Fei; Wang, Bairu; Pang, Ying; Xiang, Quanyong; Zhou, Jianwei; Wang, Xinru; Liu, Qizhan

    2013-10-01

    Cigarette smoking constitutes a major human health hazard because it is the most important risk factor for lung cancer. Although evidence for smoking-induced lung cancer in humans is strong, the molecular mechanisms by which smoking causes cancer remain to be established. In this investigation, we evaluated the roles of inflammation and the epithelial-mesenchymal transition (EMT) in cigarette smoke extract (CSE)-induced transformation of human bronchial epithelial (HBE) cells. The results showed that chronic exposure to CSE induced EMT and transformation of these cells. Activation of nuclear factor-κB (NF-κB) by CSE increased levels of the proinflammatory interleukin-6 (IL-6), and acute and chronic exposures to CSE caused decreases in miR-200c levels. By blocking NF-κB with Bay11-7082 and IL-6 with anti-IL-6 antibody and enhancement of IL-6 with human recombinant IL-6, we found that the NF-κB signal pathway was involved in CSE-induced increases of IL-6, which suppressed miR-200c expression and promoted EMT. Moreover, IL-6 was necessary for maintenance of CSE-induced transformation and for malignant progression of HBE cells. Finally, blocking of NF-κB with Bay11-7082 prevented CSE-induced EMT and malignant transformation due to decreases of E-cadherin and miR-200c and elevations of IL-6, N-cadherin, and vimentin. Thus, we have defined a link between inflammation and EMT, processes involved in the malignant transformation of cells caused by CSE. This link, mediated through miRNAs, establishes a mechanism for CSE-induced lung carcinogenesis. PMID:23824089

  4. Combining TGF-β1 knockdown and miR200c administration to optimize antitumor efficacy of B16F10/GPI-IL-21 vaccine

    PubMed Central

    Wang, Jing; Zhang, Ying; Zhang, Hongyi; Ni, Yaoyao; Sun, Jianan; Wang, Xiaobing; Dou, Jun

    2015-01-01

    TGF-β1 secreted abundantly by tumors cells as well as present in the local microenvironment promotes neoplasm invasion and metastasis by triggering the epithelial to mesenchymal transition (EMT). MiR200c has been shown to suppress EMT and to regulate the cellular epithelial and interstitial state conversion, whereas the tumor vaccines are intended to specifically initiate or amplify a host response against evolving tumor cells. Our study aimed at optimizing the antitumor effects of the B16F10/glycosylphosphatidylinositol-interleukin 21 (B16F10/GPI-IL-21) tumor vaccine on melanoma bearing mice by combining the TGF-β1 knockdown and the administration of miR200c agomir. The mice were subcutaneously vaccinated with inactivated B16F10/GPI-IL-21 vaccine and challenged by B16F10 cells transfected with shTGF-β1 (B16F10/shTGF-β1 cells) or B16F10/shTGF-β1 cells with the administration of miR200c agomir. The later combination showed that, when compared with the mice in the control group that received no vaccination, vaccinated mice significantly increased NK and CTL activities, enhanced levels of IFN-γ, and reduced expression of TGF-β1, N-cadherin, Vimentin, Gli1/2, P-Smad2/3 and others involved in promoting expression of EMT-related molecules in tumor areas, and inhibited the melanoma metastasis in lungs and lymph nodes. Altogether, our findings demonstrate that this synergistic anti-cancer regimen effectively induces strong immune response and diminishes the melanoma progression. PMID:25895132

  5. Integrated Analysis Reveals together miR-182, miR-200c and miR-221 Can Help in the Diagnosis of Prostate Cancer

    PubMed Central

    Qin, Xia; Chen, Panyu; Zou, Yi ming; Hu, Yanling

    2015-01-01

    Research has shown that microRNAs are promising biomarkers that can be used to promote a more accurate diagnosis of cancer. In this study, we developed an integrated multi-step selection process to analyze available high-throughput datasets to obtain information on microRNAs as cancer biomarkers. Applying this approach to the microRNA expression profiles of prostate cancer and the datasets in The Cancer Genome Atlas Data Portal, we identified miRNA-182, miRNA-200c and miRNA-221 as possible biomarkers for prostate cancer. The associations between the expressions of these three microRNAs with clinical parameters as well as their diagnostic capability were studied. Several online databases were used to predict the target genes of these three microRNAs, and the results were confirmed by significant statistical correlations. Comparing with the other 18 types of cancers listed in The Cancer Genome Atlas Data Portal, we found that the combination of both miRNA-182 and miRNA-200c being up-regulated and miRNA-221 being down-regulated only happens in prostate cancer. This provides a unique biological characteristic for prostate cancer that can potentially be used for diagnosis based on tissue testing. In addition, our study also revealed that these three microRNAs are associated with the pathological status of prostate cancer. PMID:26484677

  6. PLK1 Inhibition Down-regulates Polycomb Group Protein BMI1 via Modulation of the miR-200c/141 Cluster*

    PubMed Central

    Dimri, Manjari; Cho, Joon-Ho; Kang, Mingu; Dimri, Goberdhan P.

    2015-01-01

    The polycomb group protein BMI1 is an important regulator of cancer stem cell (CSC) phenotype and is often overexpressed in cancer cells. Its overexpression leads to increase in CSC fraction and therapy resistance in tumors. BMI1 functions via polycomb repressive complex 1 (PRC1)-mediated gene silencing and also via PRC1-independent transcriptional activities. At present, very little is known about the therapy reagents that can efficiently inhibit BMI1 expression, and the CSC phenotype. Here, we report that the polo-like kinase 1 (PLK1) regulates BMI1 expression, and that its inhibition can efficiently down-regulate BMI1 expression and PRC1 activity, and induce premature senescence in breast cancer cells. We also show that the exogenous BMI1 overexpression mitigates anti-oncogenic effects of PLK1 inhibition and overcomes senescence induction by PLK1 inhibitors. We further show that PLK1 inhibition down-regulates BMI1 by upregulating the miRNA-200c/141 cluster, which encodes miR-200c and miR-141, both of which are known to post-transcriptionally downregulate BMI1 expression. Thus, our data suggest that PLK1 inhibitors can be successfully used to inhibit growth of tumors in which PcG protein BMI1 is overexpressed or the PRC1 activity is deregulated. PMID:25505268

  7. Induction of the mesenchymal to epithelial transition by demethylation- activated microRNA-200c is involved in the anti-migration/invasion effects of arsenic trioxide on human breast cancer cells.

    PubMed

    Si, Lu; Jiang, Fei; Li, Yuan; Ye, Xianqing; Mu, Juan; Wang, Xingxing; Ning, Shilong; Hu, Chunyan; Li, Zhong

    2015-09-01

    Breast cancer is a major health problem worldwide. Current standard practices for treatment of breast cancer are less than satisfactory because of high rates of metastasis. Arsenic trioxide (As(2)O(3)), which induces demethylation of DNA and causes apoptosis, has been used as an anti-tumor agent. Little is known, however, regarding its anti-metastatic effects. The microRNA-200c (miR-200c), which is frequently lowly expressed in triple negative breast cancers (TNBCs), inhibits metastasis by inducing the mesenchymal to epithelial transition (MET). Here, we report that As(2)O(3) attenuates the migratory and invasive capacities of breast cancer cells, MDA-MB-231 and BT-549. Notably, As(2)O(3) induces an MET in vitro and in vivo, as determined by the increased expression of the epithelial marker, E-cadherin and decreased expressions of mesenchymal markers, N-cadherin and vimentin. Moreover, As(2)O(3) up-regulates the expression of miR-200c through demethylation. Over-expression of miR-200c enhances the expression of E-cadherin and decreases the expressions of N-cadherin and vimentin. Further, in MDA-MB-231 cells exposed to As(2)O(3), knockdown of miR-200c blocks the As(2)O(3) -induced MET. Finally, in MDA-MB-231 and BT-549 cells exposed to As(2)O(3), knockdown of miR-200c decreases the As(2)O(3) -induced inhibition of the migratory and invasive capacities. By identifying a mechanism whereby As(2)O(3) regulates miR-200c and MET, the results establish the anti-migration/invasion potential of arsenic trioxide.

  8. Silibinin suppresses EMT-driven erlotinib resistance by reversing the high miR-21/low miR-200c signature in vivo

    PubMed Central

    Cufí, Sílvia; Bonavia, Rosa; Vazquez-Martin, Alejandro; Oliveras-Ferraros, Cristina; Corominas-Faja, Bruna; Cuyàs, Elisabet; Martin-Castillo, Begoña; Barrajón-Catalán, Enrique; Visa, Joana; Segura-Carretero, Antonio; Joven, Jorge; Bosch-Barrera, Joaquim; Micol, Vicente; Menendez, Javier A.

    2013-01-01

    The flavolignan silibinin was studied for its ability to restore drug sensitivity to EGFR-mutant NSCLC xenografts with epithelial-to-mesenchymal transition (EMT)-driven resistance to erlotinib. As a single agent, silibinin significantly decreased the tumor volumes of erlotinib-refractory NSCLC xenografts by approximately 50%. Furthermore, the complete abrogation of tumor growth was observed with the co-treatment of erlotinib and silibinin. Silibinin fully reversed the EMT-related high miR-21/low miR-200c microRNA signature and repressed the mesenchymal markers SNAIL, ZEB, and N-cadherin observed in erlotinib-refractory tumors. Silibinin was sufficient to fully activate a reciprocal mesenchymal-to-epithelial transition (MET) in erlotinib-refractory cells and prevent the highly migratogenic phenotype of erlotinib-resistant NSCLC cells. Given that the various mechanisms of resistance to erlotinib result from EMT, regardless of the EGFR mutation status, a water-soluble, silibinin-rich milk thistle extract might be a suitable candidate therapy for upcoming clinical trials aimed at preventing or reversing NSCLC progression following erlotinib treatment. PMID:23963283

  9. 24 CFR 200.300 - Nondiscrimination and fair housing policy.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Nondiscrimination and fair housing policy. 200.300 Section 200.300 Housing and Urban Development Regulations Relating to Housing and Urban... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Nondiscrimination and Fair......

  10. 50 CFR 300.200 - Purpose and scope.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Purpose and scope. 300.200 Section 300.200 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS... not receive a positive certification may be subject to trade restrictive measures for certain...

  11. 50 CFR 300.200 - Purpose and scope.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Purpose and scope. 300.200 Section 300.200 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES... (“Moratorium Protection Act”) to identify and certify nations whose vessels are engaged in illegal,...

  12. miR-200c Targets a NF-κB Up-Regulated TrkB/NTF3 Autocrine Signaling Loop to Enhance Anoikis Sensitivity in Triple Negative Breast Cancer

    PubMed Central

    Howe, Erin N.; Cochrane, Dawn R.; Cittelly, Diana M.; Richer, Jennifer K.

    2012-01-01

    Anoikis is apoptosis initiated upon cell detachment from the native extracellular matrix. Since survival upon detachment from basement membrane is required for metastasis, the ability to resist anoikis contributes to the metastatic potential of breast tumors. miR-200c, a potent repressor of epithelial to mesenchymal transition, is expressed in luminal breast cancers, but is lost in more aggressive basal-like, or triple negative breast cancers (TNBC). We previously demonstrated that miR-200c restores anoikis sensitivity to TNBC cells by directly targeting the neurotrophic receptor tyrosine kinase, TrkB. In this study, we identify a TrkB ligand, neurotrophin 3 (NTF3), as capable of activating TrkB to induce anoikis resistance, and show that NTF3 is also a direct target of miR-200c. We present the first evidence that anoikis resistant TNBC cells up-regulate both TrkB and NTF3 when suspended, and show that this up-regulation is necessary for survival in suspension. We further demonstrate that NF-κB activity increases 6 fold in suspended TNBC cells, and identify RelA and NF-κB1 as the transcription factors responsible for suspension-induced up-regulation of TrkB and NTF3. Consequently, inhibition of NF-κB activity represses anoikis resistance. Taken together, our findings define a critical mechanism for transcriptional and post-transcriptional control of suspension-induced up-regulation of TrkB and NTF3 in anoikis resistant breast cancer cells. PMID:23185507

  13. Fluid-Rock Interactions at the Interface between Reservoir Rock and Cap Rock: An Experimental Case Study Regarding Mineral Trapping at 54 and 200 C

    NASA Astrophysics Data System (ADS)

    Wigand, M. O.; Carey, J. W.; Kaszuba, J. P.; Hollis, W. K.

    2006-12-01

    Geologic sequestration (underground storage) of carbon dioxide (CO2) is the most feasible approach to mitigating CO2-induced global warming while maintaining the current fossil fuel-based economy. Although simple in principle, effective implementation of geologic sequestration will require significant development of the scientific understanding of interactions among injected CO2 (as a supercritical fluid), brine, and the reservoir rock. This paper presents the results of flow-through experiments that simulated a rising plume of supercritical carbon dioxide (SCCO2) interacting at the interface between reservoir rock and cap rock in a brine- saturated aquifer. We performed two high pressure flow-through experiments using powdered limestone and illite-rich shale separated by a frit with a pore size of 10 μm. One experiment was performed under in-situ pressure (2880 psi) and temperature (54°C) conditions of a typical oil reservoir in the Permian Basin. To increase the kinetic rates of the mineral reactions we also performed an experiment at elevated temperatures (200°C) but using the same boundary conditions for other experimental parameters such as pressure, rock samples, fluids, injection rates, and time span. Both experiments were performed over 3263 hours. After the experiment eight disks of equal size representing different reaction zones were cut to investigate the progressive fluid-rock interaction of the reservoir and cap rock with the mixture of SCCO2 and brine. Additionally, fluid samples were frequently collected and their compositions were analyzed using inductively coupled plasma mass spectrometry. At in-situ temperature conditions we determined an enrichment of B, Ba, Cr, Cu, Fe, K, Li, Mg, Na, Ni, Rb, Si, Sr, Ti, Zn, and sulfate in the collected brines, whereas Mn and chloride concentrations were depleted in comparison with the starting composition. Ca and Al showed uneven behavior with changes in enrichment and depletion during the experiment. At 200

  14. A Long-Lived Fe(III)-(Hydroperoxo) Intermediate in the Active H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Characterization by Mössbauer, Electron Paramagnetic Resonance, and Density Functional Theory Methods.

    PubMed

    Meier, Katlyn K; Rogers, Melanie S; Kovaleva, Elena G; Mbughuni, Michael M; Bominaar, Emile L; Lipscomb, John D; Münck, Eckard

    2015-11-01

    The extradiol-cleaving dioxygenase homoprotocatechuate 2,3-dioxygenase (HPCD) binds substrate homoprotocatechuate (HPCA) and O2 sequentially in adjacent ligand sites of the active site Fe(II). Kinetic and spectroscopic studies of HPCD have elucidated catalytic roles of several active site residues, including the crucial acid-base chemistry of His200. In the present study, reaction of the His200Cys (H200C) variant with native substrate HPCA resulted in a decrease in both kcat and the rate constants for the activation steps following O2 binding by >400 fold. The reaction proceeds to form the correct extradiol product. This slow reaction allowed a long-lived (t1/2 = 1.5 min) intermediate, H200C-HPCAInt1 (Int1), to be trapped. Mössbauer and parallel mode electron paramagnetic resonance (EPR) studies show that Int1 contains an S1 = 5/2 Fe(III) center coupled to an SR = 1/2 radical to give a ground state with total spin S = 2 (J > 40 cm(-1)) in Hexch = JŜ1·ŜR. Density functional theory (DFT) property calculations for structural models suggest that Int1 is a (HPCA semiquinone(•))Fe(III)(OOH) complex, in which OOH is protonated at the distal O and the substrate hydroxyls are deprotonated. By combining Mössbauer and EPR data of Int1 with DFT calculations, the orientations of the principal axes of the (57)Fe electric field gradient and the zero-field splitting tensors (D = 1.6 cm(-1), E/D = 0.05) were determined. This information was used to predict hyperfine splittings from bound (17)OOH. DFT reactivity analysis suggests that Int1 can evolve from a ferromagnetically coupled Fe(III)-superoxo precursor by an inner-sphere proton-coupled-electron-transfer process. Our spectroscopic and DFT results suggest that a ferric hydroperoxo species is capable of extradiol catalysis. PMID:26485328

  15. Contrôle de la température durant le processus de dégradation d'un acier Z12CNS20 en frottement avec un acier Z200C13

    NASA Astrophysics Data System (ADS)

    Khanafi-Benghalem, N.; Loucif, K.; Benghalem, K.; Boudoukha, H.; Louahdi, R.

    2005-05-01

    La température de contact lors des essais d'usure varie d'une manière spontanée et aléatoire. Cette température de contact dépend essentiellement de la nature du couple des matériaux en contact de la charge et de la vitesse. Cependant la mesure de la température est très difficile à effectuer compte tenu du choix de l'endroit de prise de la température et des phénomènes d'évacuation de la chaleur et de la dissipation de l'énergie. Dans ce travail nous exposons une méthode très simple de mesure de la température et nous étudions par conséquent la variation de la température du Z12CNS20 / Z200C13. Au cours des essais d'usure pour différentes vitesses de glissement, nous montrons en effet que la température augmente d'une manière progressive en fonction de la vitesse puis elle s'élève brutalement au fur et à mesure qu'on se rapproche du point de contact, et enfin nous prouvons par observation métallographique que l'échantillon subit un écoulement plastique provoqué par l'élévation de la température en fonction de la vitesse.

  16. 76 FR 24351 - Airworthiness Directives; Airbus Model A340-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant...-200 and -300 Series Airplanes AGENCY: Federal Aviation Administration (FAA), Department...

  17. 24 CFR 200.300 - Nondiscrimination and fair housing policy.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... administered in accordance with: (a) The nondiscrimination and fair housing requirements set forth in 24 CFR part 5; and (b) The affirmative fair housing marketing requirements in 24 CFR part 200, subpart M and 24 CFR part 108....

  18. 24 CFR 200.300 - Nondiscrimination and fair housing policy.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... administered in accordance with: (a) The nondiscrimination and fair housing requirements set forth in 24 CFR... forth in 24 CFR 5.105(a)(2); and (b) The affirmative fair housing marketing requirements in 24 CFR part 200, subpart M and 24 CFR part 108....

  19. 24 CFR 200.300 - Nondiscrimination and fair housing policy.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... administered in accordance with: (a) The nondiscrimination and fair housing requirements set forth in 24 CFR... forth in 24 CFR 5.105(a)(2); and (b) The affirmative fair housing marketing requirements in 24 CFR part 200, subpart M and 24 CFR part 108....

  20. 24 CFR 200.300 - Nondiscrimination and fair housing policy.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... administered in accordance with: (a) The nondiscrimination and fair housing requirements set forth in 24 CFR... forth in 24 CFR 5.105(a)(2); and (b) The affirmative fair housing marketing requirements in 24 CFR part 200, subpart M and 24 CFR part 108....

  1. Environmental assessment for the salvage/demolition of 200 West Area, 200 East Area, and 300 Area steam plants

    SciTech Connect

    1996-10-01

    This environmental assessment has been prepared to assess potential environmental impacts associated with the US Department of Energy`s proposed action: the salvage/demolition of the 200 West Area, 200 East Area, and 300 Area Steam Plants and steam distribution piping. Impact information will be used by the US Department of Energy, Richland Operations Office Manager, to determine if the proposed action is a major federal action significantly affecting the quality of the human environment. If the proposed action is determined to be major and significant, an environmental impact statement will be prepared. If the proposed action is determined not to be major and significant, a Finding of No Significant Impact (FONSI) will be issued and the action can proceed. The proposed action involves the salvage and demolition of the 200 West Area, 200 East Are, and 300 Area steam plants and their associated steam distribution piping, equipment, and ancillary facilities. Activities include the salvaging and recycling of all materials, wastes, and equipment where feasible, with waste minimization efforts utilized.

  2. The system water-sodium oxide-silicon dioxide at 200, 250, and 300°

    USGS Publications Warehouse

    Rowe, Jack J.; Fournier, Robert O.; Morey, G.W.

    1967-01-01

    Studies were made of the H2O-Na2O-SiO2 system at its vapor pressure at 200, 250, and 300??. Three different sodium trisilicate hydrates were encountered in the investigation. At 300??, Na2Si3O7??5H2O is found: at 250??, Na2Si3O7??6H2O; and at 200??, Na2Si3O7??11H2O. The liquid immiscibility previously reported to exist in the system was found to be a quenching phenomenon caused by the decomposition of the hydrates to unstable, supersaturated, viscous liquids. Under conditions where equilibrium is maintained, as temperature is lowered, the hydrates decompose to quartz, sodium disilicate, and liquid. The retrograde solubility of sodium disilicate and its tendency to form supersaturated solutions during heating from 25 to 250?? account for higher solubilities reported by others than were found in this study. The solubility of sodium disilicate in water is 26% at 200??, 9% at 250??, and 5% at 300??. Sodium metasilicate solubility is 38% at 200?? and 34% at 250??; this compound is incongruently soluble at 300??.

  3. 76 FR 15867 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ...-09-07, Amendment 39-14577 (71 FR 25919, May 3, 2006). That AD requires actions intended to address an... 39-16605 (76 FR 8612, February 15, 2011), for Airbus Model A340-200, -300, -500, and -600 series... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR...

  4. 76 FR 53305 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... (76 FR 8610, February 15, 2011), addresses Model A340-200, -300, -500, and -600 series airplanes. (2... reference of a certain other publication listed in this AD as of June 7, 2006 (71 FR 25919, May 3, 2006... (76 FR 15872). That NPRM proposed to correct an unsafe condition for the specified products. The...

  5. 76 FR 15872 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... issued AD 2006-09-07, Amendment 39-14577 (71 FR 25919, May 3, 2006), that applies to Airbus Model A330... FR 8610, February 15, 2011), for Airbus Model A340-200, -300, -500, and -600 series airplanes, to... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3....

  6. Fluorescent-based lifetime measurement thermometer for use at subroom temperatures (200-300 K)

    NASA Astrophysics Data System (ADS)

    Anghel, F.; Iliescu, C.; Grattan, K. T. V.; Palmer, A. W.; Zhang, Z. Y.

    1995-03-01

    The development, construction, and evaluation of a simple ruby-based fiber optic thermometer, for use over the region 200-300 K, are described. The results are compared with those obtained from a simple theoretical model, which may be used for system calibration, and with those of previously published work, and good agreement is seen. The application of such a sensor to the food processing industry and environmental monitoring is indicated.

  7. 76 FR 4219 - Airworthiness Directives; Airbus Model A330-200 Series Airplanes; Model A330-300 Series Airplanes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-25

    ... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant...-200 Series Airplanes; Model A330-300 Series Airplanes; Model A340-200 Series Airplanes; and Model A340-300 Series Airplanes AGENCY: Federal Aviation Administration (FAA), Department of Transportation...

  8. 75 FR 28475 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes, and Model A340-300...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-21

    ... products. That NPRM was published in the Federal Register on October 19, 2009 (74 FR 53440). That NPRM...'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have...-200 and -300 Series Airplanes, and Model A340-300 Series Airplanes AGENCY: Federal...

  9. Thermal quenching of thermoluminescence in TLD-200, TLD-300 and TLD-400 after β-irradiation

    NASA Astrophysics Data System (ADS)

    Kafadar, Vural E.

    2011-02-01

    The dosimetric characteristics of many TL materials are influenced by changes in location, size and shape of the glow curves due to changes in the heating rate. In this study, the effect of heating rate on the integrated peak areas of CaF 2:Dy (TLD-200), CaF 2:Tm (TLD-300) and CaF 2:Mn (TLD-400) crystals have been investigated after β-irradiation. It was observed that the peak temperatures of all peaks shifted to the high temperature sides and the integrated peak areas decrease as the heating rate increases due to thermal quenching, whose efficiency increases as temperature increases.

  10. 75 FR 9515 - Airworthiness Directives; Airbus Model A330-200 Series Airplanes and Model A340-200 and -300...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-03

    ...-16202; AD 2010-04-09] RIN 2120-AA64 Airworthiness Directives; Airbus Model A330-200 Series Airplanes and Model A340-200 and -300 Series Airplanes Correction In rule document 2010-3119 beginning on page 7940...

  11. 78 FR 76731 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Rechargeable Lithium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    ... battery systems special conditions adopted for the Boeing Model 787 (72 FR 57842; October 11, 2007..., -300, and -300ER series airplanes, was published in the Federal Register on August 22, 2013 (78 FR... Series Airplanes; Rechargeable Lithium Ion Batteries and Battery Systems AGENCY: Federal...

  12. Experimental Study of a 200-300 GHZ Megawatt Gyrotron Oscillator

    NASA Astrophysics Data System (ADS)

    Grimm, Terry L.

    A detailed experimental study is presented of a pulsed megawatt gyrotron oscillator operating in the 200-300 GHz range whose design is consistent with continuous operation for ECRH of fusion plasmas. A cylindrical waveguide cavity over 20 free space wavelengths in diameter was designed to limit ohmic wall losses in the copper cavity to less than 2 kW/cm^2. The frequency spacing between TE waveguide modes in this highly overmoded cavity is less than 2%. The cavity is positioned at the peak magnetic field of a 14 T Bitter magnet. Two different radii beams produced by magnetron injection guns (MIGs) were used to excite the cavity. The large and small MIG guns produced annular beams of 0.75 cm and 0.45 cm radius respectively. The guns operate with beam currents approaching 60 A and voltages as high as 100 kV. The voltage is produced by a line-type modulator with a pulse length of 3 mu s at a repetition rate of up to 4 Hz. Experimental results have shown that megawatt power levels can be generated in CW gyrotron oscillators at 200-300 GHz with efficiencies approaching 20%. The emission is single mode, single frequency with a single rotation which can easily be mode converted for transmission. No multimoding was observed at the high powers and efficiencies. The highest power reached with the large MIG gun was 0.97 MW at 230 GHz in the TE_{34,6} mode with an efficiency of 18% and beam parameters of 59 A and 90 kV. This was the peak efficiency which was also obtained at 290 GHz in the TE_{41,8 } mode with a power of 0.89 MW and beam parameters of 54 A and 93 kV. The highest power reached with the small MIG gun was 0.78 MW at 280 GHz in the TE _{25,13} mode with an efficiency of 17% and beam parameters of 51 A and 92 kV. The small MIG gun peak efficiency was also 18% at 0.72 MW, 290 GHz in the TE_{25,14} mode. Efficiencies obtained in this experiment are about half of less highly overmoded gyrotrons. Analysis of the experiment shows mode competition is the main cause of the

  13. Experimental study of a 200--300 GHz megawatt gyrotron oscillator

    SciTech Connect

    Grimm, T.L.

    1992-01-01

    An experimental study is presented of a pulsed megawatt gyrotron oscillator operating in the 200-300 GHz range whose design is consistent with continuous operation for ECRH of fusion plasmas. A cylindrical waveguide cavity over 20 free space wavelengths in diameter was designed to limit ohmic wall losses in the copper cavity to < 2 kW/cm[sup 2]. The frequency spacing between TE waveguide modes in this highly overmoded cavity is < 2%. The cavity is positioned at the peak magnetic field of a 14 T Bitter magnet. Two different radii beams produced by magnetron injection guns (MIGs) were used to excite the cavity. The large and small MIG guns produced annual beams of 0.75 cm and 0.45 cm radius. The guns operate with beam currents approaching 60 A and voltages as high as 100 kV. The voltage is produced by a line-type modulator with a pulse length of 3 [mu]s at a repetition rate of up to 4 Hz. Megawatt power levels can be generated in CW gyrotron oscillators at 200-300 GHz with efficiencies approaching 20%. The emission is single mode, single frequency with a single rotation which can easily be mode converted for transmission. No multimoding was observed at the high powers and efficiencies. The highest power reached with the large MIG gun was 0.97 MW at 230 GHz in the TE[sub 34,6] mode with an efficiency of 18% and beam parameters of 59 A and 90kV. This was the peak efficiency which was also obtained at 290 GHz in the TE[sub 41,8] mode with a power of 0.89 MW and beam parameters of 54 A and 93 kV. The highest power with the small MIG gun was 0.78 MW at 280 GHz in the TE[sub 25,13] mode with an efficiency of 17% and beam parameters of 51 A and 92 kV. The small MIG gun peak efficiency was 18% at 0.72 MW, 290 GHz in the TE[sub 25,14] mode. Efficiencies are about half of less highly overmoded gyrotrons. Mode competition is the main cause of the low efficiency, with voltage depression, beam thickness and velocity spread contributing only a fraction to the decrease.

  14. 75 FR 64633 - Airworthiness Directives; The Boeing Company Model 767-200, -300, and -300F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... publication listed in this AD as of November 5, 2009 (74 FR 50692, October 1, 2009). We must receive comments..., we issued AD 2009-20-09, Amendment 39-16032 (74 FR 50692, October 1, 2009), for certain Model 767-200... this AD terminate certain requirements of AD 2000-19-09, Amendment 39-11910 (65 FR 58641, October...

  15. The effects of heating rate on the dose response characteristics of TLD-200, TLD-300 and TLD-400

    NASA Astrophysics Data System (ADS)

    Kafadar, V. Emir; Necmeddin Yazici, A.; Güler Yildirim, R.

    2009-10-01

    In the given study; the effects of heating rates on the dose response characteristics of CaF 2:Dy (TLD-200), CaF 2:Tm (TLD-300) and CaF 2:Mn (TLD-400) crystals have been investigated using the dose dependence curve and dose response function f( D). It was observed from the dose response functions that the linearity and behaviour of the TL glow peaks of TLD-200 and TLD-400 are affected, but the TLD-300 is not affected from the heating rate.

  16. 76 FR 8612 - Airworthiness Directives; Airbus Model A340-200, -300, -500, and -600 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... 2006-09-07, Amendment 39-14577 (71 FR 25919, May 3, 2006), for all Airbus Model A330-200 and -300, and...'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have.... Adapted airworthiness limitations were introduced in Airbus A340 Airworthiness Limitations Section...

  17. DISPLACEMENT CASCADE SIMULATION IN TUNGSTEN UP TO 200 KEV OF DAMAGE ENERGY AT 300, 1025, AND 2050 K

    SciTech Connect

    Setyawan, Wahyu; Nandipati, Giridhar; Roche, Kenneth J.; Kurtz, Richard J.; Wirth, Brian D.

    2015-09-22

    We generated molecular dynamics database of primary defects that adequately covers the range of tungsten recoil energy imparted by 14-MeV neutrons. During this semi annual period, cascades at 150 and 200 keV at 300 and 1025 K were simulated. Overall, we included damage energy up to 200 keV at 300 and 1025 K, and up to 100 keV at 2050 K. We report the number of surviving Frenkel pairs (NF) and the size distribution of defect clusters. The slope of the NF curve versus cascade damage energy (EMD), on a log-log scale, changes at a transition energy (μ). For EMD > μ, the cascade forms interconnected damage regions that facilitate the formation of large clusters of defects. At 300 K and EMD = 200 keV, the largest size of interstitial cluster and vacancy cluster is 266 and 335, respectively. Similarly, at 1025 K and EMD = 200 keV, the largest size of interstitial cluster and vacancy cluster is 296 and 338, respectively. At 2050 K, large interstitial clusters also routinely form, but practically no large vacancy clusters do

  18. Life Test Results for Water Heat Pipes Operating at 200 °C to 300 °C

    NASA Astrophysics Data System (ADS)

    Rosenfeld, John H.; Gernert, Nelson J.

    2008-01-01

    For lunar or planetary bases to be viable, a robust electric generating system will be required for powering the habitat. Water heat pipes offer an attractive solution for lunar base heat rejection, and would serve as a qualification for them on other long duration missions. Successful operation near the upper end of water operating range is a requirement for the application. Results are reported for life tests on water heat pipes that were operated at various temperatures between 200 °C and 300 °C. Tests were conducted on twenty three gravity-assisted water heat pipes. Eleven titanium/water heat pipes and ten Monel/water heat pipes were tested at temperatures above 200 °C. Two cupronickel heat pipes were also assembled and tested. Titanium alloys tested included CP-2 titanium, as well as two beta-titanium alloys, namely 15-3 and Nitinol alloys. Some of the titanium alloy life tests used wicks fabricated from CP-2 titanium screen or porous felt. Monel alloys tested included 400 and K-500 alloys. Some of the Monel heat pipes contained copper/nickel wicks that were fabricated by brazing nickel-plated copper felt metal wicks. Although most of the envelope/material combinations exhibit favorable results at 200 °C, some of the combinations failed at higher temperatures. Causes of failure included stress-creep of envelopes and corrosion at axial or end cap welds. This information represents a significant advance in selection of materials for 200 °C to 300 °C water heat pipes. Life testing work is being continued.

  19. Phenotypes and Virulence among Staphylococcus aureus USA100, USA200, USA300, USA400, and USA600 Clonal Lineages

    PubMed Central

    King, Jessica M.; Kulhankova, Katarina; Stach, Christopher S.; Vu, Bao G.

    2016-01-01

    ABSTRACT Staphylococcus aureus diseases affect ~500,000 individuals per year in the United States. Worldwide, the USA100, USA200, USA400, and USA600 lineages cause many of the life-threatening S. aureus infections, such as bacteremia, infective endocarditis, pneumonia, toxic shock syndrome, and surgical site infections. However, the virulence mechanisms associated with these clonal lineages, in particular the USA100 and USA600 isolates, have been severely understudied. We investigated the virulence of these strains, in addition to strains in the USA200, USA300, and USA400 types, in well-established in vitro assays and in vivo in the rabbit model of infective endocarditis and sepsis. We show in the infective endocarditis and sepsis model that strains in the USA100 and USA600 lineages cause high lethality and are proficient in causing native valve infective endocarditis. Strains with high cytolytic activity or producing toxic shock syndrome toxin 1 (TSST-1) or staphylococcal enterotoxin C (SEC) caused lethal sepsis, even with low cytolytic activity. Strains in the USA100, USA200, USA400, and USA600 lineages consistently contained genes that encode for the enterotoxin gene cluster proteins, SEC, or TSST-1 and were proficient at causing infective endocarditis, while the USA300 strains lacked these toxins and were deficient in promoting vegetation growth. The USA100, USA200, and USA400 strains in our collection formed strong biofilms in vitro, whereas the USA200 and USA600 strains exhibited increased blood survival. Hence, infective endocarditis and lethal sepsis are multifactorial and not intrinsic to any one individual clonal group, further highlighting the importance of expanding our knowledge of S. aureus pathogenesis to clonal lineages causative of invasive disease. IMPORTANCE S. aureus is the leading cause of infective endocarditis in the developed world, affecting ~40,000 individuals each year in the United States, and the second leading cause of bacteremia (D

  20. 200 and 300 MeV/nucleon nuclear reactions responsible for single-event effects in microelectronics

    SciTech Connect

    Jaederstroem, H.; Murin, Yu.; Babain, Yu.; Chubarov, M.; Pljuschev, V.; Zubkov, M.; Nomokonov, P.; Olsson, N.; Blomgren, J.; Tippawan, U.; Westerberg, L.; Golubev, P.; Jakobsson, B.; Geren, L.; Tegner, P.-E.; Zartova, I.; Budzanowski, A.; Czech, B.; Skwirczynska, I.; Kondratiev, V.

    2008-04-15

    An experimental study of nuclear reactions between {sup 28}Si nuclei at 200 and 300 MeV/nucleon and hydrogen or deuterium target nuclei was performed at the CELSIUS storage ring in Uppsala, Sweden, to collect information about the reactions responsible for single-event effects in microelectronics. Inclusive data on {sup 28}Si fragmentation, as well as data on correlations between recoils and spectator protons or {alpha} particles are compared to predictions from the Dubna cascade model and the Japan Atomic Energy Research Institute version of the quantum molecular dynamics model. The comparison shows satisfactory agreement for inclusive data except for He fragments where low-energy sub-barrier fragments and recoiling fragments with very large momenta are produced much more frequently than predicted. The yield of exclusive data are also severely underestimated by the models whereas the charge distributions of recoils in these correlations compare well. The observed enhancement in He emission, which may well be important for the description of single-event effects, is most likely to be attributed to {alpha} clustering in {sup 28}Si nuclei.

  1. 200 and 300 MeV/nucleon nuclear reactions responsible for single-event effects in microelectronics

    NASA Astrophysics Data System (ADS)

    Jäderström, H.; Murin, Yu.; Babain, Yu.; Chubarov, M.; Pljuschev, V.; Zubkov, M.; Nomokonov, P.; Olsson, N.; Blomgren, J.; Tippawan, U.; Westerberg, L.; Golubev, P.; Jakobsson, B.; Gerén, L.; Tegnér, P.-E.; Zartova, I.; Budzanowski, A.; Czech, B.; Skwirczynska, I.; Kondratiev, V.; Tang, H. H. K.; Aichelin, J.; Watanabe, Y.; Gudima, K. K.

    2008-04-01

    An experimental study of nuclear reactions between Si28 nuclei at 200 and 300 MeV/nucleon and hydrogen or deuterium target nuclei was performed at the CELSIUS storage ring in Uppsala, Sweden, to collect information about the reactions responsible for single-event effects in microelectronics. Inclusive data on Si28 fragmentation, as well as data on correlations between recoils and spectator protons or α particles are compared to predictions from the Dubna cascade model and the Japan Atomic Energy Research Institute version of the quantum molecular dynamics model. The comparison shows satisfactory agreement for inclusive data except for He fragments where low-energy sub-barrier fragments and recoiling fragments with very large momenta are produced much more frequently than predicted. The yield of exclusive data are also severely underestimated by the models whereas the charge distributions of recoils in these correlations compare well. The observed enhancement in He emission, which may well be important for the description of single-event effects, is most likely to be attributed to α clustering in Si28 nuclei.

  2. 76 FR 36011 - Airworthiness Directives; Fokker Services B.V. Model F.27 Mark 050, 200, 300, 400, 500, 600, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-21

    ...'' (66 FR 23086, May 7, 2001). In addition to new airworthiness standards for transport airplanes and new... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will.... Model F.27 Mark 050, 200, 300, 400, 500, 600, and 700 Airplanes; and Model F.28 Airplanes...

  3. Petrogenesis of the Crystal Vitric Tuffs recovered 300 km Northeast of Oahu, from ODP Leg 200: Pyroclastic or Landslide Deposit?

    NASA Astrophysics Data System (ADS)

    Sherman, S. B.; Garcia, M. O.

    2003-12-01

    Hawaiian volcanoes frequently experience flank failure that generate landslides, debris flows, and turbidity currents. The largest landslide known to have occurred on the Hawaiian islands is the Nuuanu landslide. The Nuuanu landslide resulted from the collapse of Koolau volcano on the island of Oahu, Hawaii approximately 2 million years ago where 40% of the Koolau volcano was removed. An ancillary objective of ODP Leg 200 was to drill the distal facies of the deposits emplaced during the Nuuanu landslide. The actual date and the mechanics of this landslide had not been well constrained. It is not known whether the landslide occurred as a single catastrophic event or as a series of collapses. One of the justifications for drilling the Nuuanu landslide deposit was thus to better understand how this and other similar landslides occur. Because they are relatively common events on volcanic islands such an understanding is highly desirable. In addition, there are major potential hazards associated with landslides, e.g., tsunami generation and as in the case of Mt. St. Helens, explosive eruptions. The location of site 1223a is 300 km northeast of Oahu on the crest of the Hawaiian arch. The depth of the hole reaches 41 meters below the seafloor (mbsf) and 23.5 m of core was recovered (61% recovery). Three main types of lithologies were recovered: unconsolidated clays and volcaniclastic turbidites, consolidated volcaniclastic siltstones and claystones, and lithified crystal vitric tuffs. Only 12.7 mbsf was drilled before encountering an ˜ 3 m thick bed of lithified crystal vitric tuff. A second 4 m thick crystal vitric tuff was recovered at 33 mbsf. The main components of both of the crystal vitric tuffs, in order of abundance, are volcanic glass, mineral fragments (the majority are olivine and plagioclase with minor amounts of pyroxene) clay and zeolites, predominantly phillopsite. The volcaniclastic siltstones and claystones contain the same components. Chlorite is found

  4. 75 FR 5692 - Airworthiness Directives; The Boeing Company Model 747-200C and -200F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... published in the Federal Register on July 6, 2009 (74 FR 31894). That NPRM proposed to require a high... 2005- 07-21, Amendment 39-14046 (70 FR 18277, April 11, 2005), is required during the accomplishment of... alternative method of compliance (AMOC) for paragraphs (f) and (g) of AD 2006-08-02, Amendment 39-14556 (71...

  5. 75 FR 16651 - Airworthiness Directives; The Boeing Company Model 747-200C and -200F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... supersedes AD 2006-08-02, amendment 39-14556 (70 FR 18618, April 12, 2006). The existing AD applies to... August 12, 2009 (74 FR 40529). That NPRM proposed to continue to require repetitive inspections to find...'' under DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and (3) Will not have...

  6. Effect of high-pressure treatment of ewe raw milk curd at 200 and 300 MPa on characteristics of Hispánico cheese.

    PubMed

    Alonso, R; Picon, A; Gaya, P; Fernández-García, E; Nuñez, M

    2012-07-01

    Hispánico cheese is a semihard variety made from a mixture of cow and ewe milks. Production of ewe milk declines in summer and autumn. To surmount the seasonal shortage of ewe milk and prevent the inactivation of milk enzymes by pasteurization, curd made in spring from ewe raw milk was pressurized at 200 and 300 MPa and stored frozen for 4 mo. Thawed ewe milk curds were added to fresh curd made from pasteurized cow milk for the manufacture of experimental Hispánico cheeses. Control cheese was made from a mixture of pasteurized cow and ewe milk in the same proportions as those used for experimental cheeses. Experimental cheeses exhibited lower dry matter content, higher aminopeptidase activity and total free amino acid concentration, and higher levels of acetic and propionic acids, aldehydes, alcohols, and esters compared with control cheese. In contrast, the concentration of total free fatty acids and ketones and the levels of textural parameters were significantly higher in control cheese. The use of ewe raw milk curd pressurized at 200 and 300 MPa, stored frozen and thawed for Hispánico cheese manufacture, was generally beneficial for cheese characteristics and increased cheese yield because of the lower dry matter content of experimental cheeses.

  7. Novel spin-coating technology for 248-nm/193-nm DUV lithography and low-k spin on dielectrics of 200-mm/300-mm wafers

    NASA Astrophysics Data System (ADS)

    Gurer, Emir; Zhong, Tom X.; Lewellen, John W.; Lee, Ed C.

    2000-06-01

    An alternative coating technology was developed for 248 nm/193 nm DUV lithography and low-k spin on dielectric (SOD) materials used in the interconnect area. This is a 300 mm enabling technology which overcomes turbulent flow limitations above 2000 rpm and it prevents 40 - 60% reduction on the process latitudes of evaporation-related variables, common to 300 mm conventional coaters. Our new coating technology is fully enclosed and it is capable of controlling the solvent concentration above the resist film dynamically in the gas phase. This feature allows a direct control of the evaporation mass transfer which determines the quality of the final resist profiles. Following process advantages are reported in this paper: (1) Demonstrated that final resist film thickness can be routinely varied by 4000 angstrom at a fixed drying spin speed, thus minimizing the impact of turbulence wall for 300 mm wafers. (2) Evaporation control allows wider range of useful thickness from a fixed viscosity material. (3) Latitudes of evaporation-related process variables is about 40% larger than that of a conventional coater. (4) Highly uniform films of 0.05% were obtained for 8800 angstrom target thickness with tighter wafer-wafer profile control because of the enclosed nature of the technology. (5) Dynamic evaporation control facilitates resist consumption minimization. Preliminary results indicate feasibility of a 0.4 cc process of record (POR) for a 200 mm substrate. (6) Lower COO due to demonstrated relative insensitivity to environmental variables, robust resist consumption minimization and superior process capabilities. (7) Improved planarization and gap fill properties for the new generation photoresist/low-k SOD materials deposited using this enclosed coating technology.

  8. Neurological syndrome in an HIV-prevention trial participant randomized to daily tenofovir disoproxil fumarate (300 mg) and emtricitabine (200 mg) in Bondo, Kenya

    PubMed Central

    Owino, Fredrick; Mandala, Justin; Ambia, Julie; Agot, Kawango; Van Damme, Lut

    2013-01-01

    Side effects of antiretroviral drug use by HIV-positive patients have been extensively studied; however, there are limited data on the side effects of antiretroviral drugs used as an HIV prophylaxis among healthy, HIV-negative individuals. Here we report on an unusual neuropathy in a 24-year-old participant in the FEM-PrEP trial. This was a Phase III randomized, double blind, placebo-controlled trial to test the safety and effectiveness of tenofovir disoproxil fumarate (300 mg) and emtricitabine (200 mg) (TDF-FTC) to prevent HIV. At the eighth week of taking TDF-FTC with moderate adherence, the participant complained of mild paresthesiae, numbness, and a tingling sensation in her upper limbs that was associated with pain and cold. After an additional 4 days, she developed a disabling weakness of her upper limbs and tremors in her hands. The study product was discontinued, and within 2 weeks she was free of all symptoms. One month after restarting the drug, she complained of posture-dependent numbness of her upper limbs. Results of clinical and neurological exams, laboratory tests, and magnetic resonance imaging are described here. PMID:24353443

  9. Formation of CO2, H2 and condensed carbon from siderite dissolution in the 200-300 °C range and at 50 MPa

    NASA Astrophysics Data System (ADS)

    Milesi, Vincent; Guyot, François; Brunet, Fabrice; Richard, Laurent; Recham, Nadir; Benedetti, Marc; Dairou, Julien; Prinzhofer, Alain

    2015-04-01

    Laboratory experiments were conducted to investigate the chemical processes governing the carbon speciation associated to hydrothermal decomposition of siderite. Experiments were carried out in sealed gold capsules using synthetic siderite and deionised water. The samples were reacted at 200 and 300 °C, under a pressure of 50 MPa. Siderite dissolved to reach the 3FeCO3 + H2O = Fe3O4 + 3CO2 + H2 equilibrium and magnetite, Fe3O4, was produced accordingly. The gas phase was dominated by CO2, H2 and CH4, the latter being in strong thermodynamic disequilibrium with CO2. Contrary to the other gas products, H2 concentration was found to decrease with run duration. TEM observations showed the occurrence of condensed carbon phases at the surfaces of magnetite and residual siderite grains. Thermodynamic calculations predict the formation of condensed carbon in the experiments according to the reaction: CO2 + 2H2 ⇒ C + 2H2O, which accounted for the observed H2 concentration decrease up to the point where H2 and CO2 activities were buffered by the graphite-siderite-magnetite assemblage. The well-organized structure of the carbon coating around magnetite emphasizes the high catalytic potential of magnetite surface for carbon reduction and polymerization. The formation of such C-rich phases may represent a potential source of CH4 by hydrogenation. On the other hand, the catalysis of Fischer-Tropsch type reactions may be poisoned by the presence of carbon coating on mineral surfaces. In any case, this study also demonstrates that abiotic H2 generation by water reduction, widely studied in recent years in ultrabasic contexts, can also occur in sedimentary contexts where siderite is present. We show that, in the latter case, natural H2 concentration will be buffered by a condensed carbon phase associated with magnetite.

  10. Viscous Heating of Ions through Saturated Fine-Scale MHD Instabilities in a Z-Pinch at 200-300 KeV Temperature

    NASA Astrophysics Data System (ADS)

    Haines, Malcolm; Coverdale, Christine; Deeney, Chris; Lepell, P. David; Jones, Brent; Apruzese, J. P.

    2006-10-01

    Pulsed power driven Z-pinches yield large X-ray powers at stagnation, the energy of which can exceed by up to factors of 3 or 4, the estimated kinetic energy of the implosion. Furthermore, when electron temperatures are measured at stagnation similar in temperatures would not lead to pressure balance. These problems can be resolved by a theoretical model in which short wavelength (ka >> 1, and viscous Lundquist number ˜ 1), fast growing, m=O MHD instabilities reach a saturated amplitude, and the associated viscous dissipation of the vortices leads to ion heating. Equating this heating rate to the equipartition of energy to electrons leads to an estimate of the ion temperature and pinch radius at pressure balance. Extremely high ion temperatures in the range of 200-300 KeV are predicted from this model for stainless steel wire array experiments on Z at Sandia. These have been confirmed from time-resolved Doppler broadening spectroscopic measurements of the optically thin Fe He-δ line. This conversion of magnetic energy into ion thermal energy occurs on the nanosecond timescale, and can prevent radiative collapse. Any accompanying loss of magnetic flux in this highly conducting plasma can be explained by the occurrence of a large number of hot spots along the axis, with electron density and temperature variating not exactly in phase. This leads to a significant value of the integral of E.dl. Dl along the axis due to the grad Pe term in Ohm's law, analogous to the magnetic field generating term found in laser-plasma interactions. Ref 1. M.G. Haines, et al; Phys. Rev. Lett. 96, 075003 (2006) Sandia is a multiprogram laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy under Contract DE-ACO4-94AL85000.

  11. Exploring the cell: Sodium (beta-alumina) cupric chloride - Aluminum chloride - Sodium chloride between 136 and 200 C

    NASA Technical Reports Server (NTRS)

    Miller, R. O.

    1975-01-01

    Experiments were done with a molten-salt catholyte (initially CuCl2 in AlCl3-NaCl) separated from molten Na by beta alumina. The open-circuit reduction potentials were 4.3 and 3 volts for Cu++ and Cu+, respectively. High polarization and nonrechargeability characterized the cell's operation. The cell's ohmic resistance during discharge was higher than what would be expected from only the ionic resistance of the beta-alumina.

  12. Static and Turn-on Switching Characteristics of 4H-Silicon Carbide SITs to 200 deg C

    NASA Technical Reports Server (NTRS)

    Niedra, Janis M.; Schwarze, Gene E.

    2005-01-01

    Test results are presented for normally-off 4H-SiC Static Induction Transistors (SITs) intended for power switching and are among the first normally-off such devices realized in SiC. At zero gate bias, the gate p-n junction depletion layers extend far enough into the conduction channel to cut off the channel. Application of forward gate bias narrows the depletion regions, opening up the channel to conduction by majority carriers. In the present devices, narrow vertical channels get pinched by depletion regions from opposite sides. Since the material is SiC, the devices are usable at temperatures above 150 C. Static curve and pulse mode switching observations were done at selected temperatures up to 200 C on a device with average static characteristics from a batch of similar devices. Gate and drain currents were limited to about 400 mA and 3.5 A, respectively. The drain voltage was limited to roughly 300 V, which is conservative for this 600 V rated device. At 23 C, 1 kW, or even more, could be pulse mode switched in 65 ns (10 to 90 percent) into a 100 load. But at 200 C, the switching capability is greatly reduced in large part by the excessive gate current required. Severe collapse of the saturated drain-to-source current was observed at 200 C. The relation of this property to channel mobility is reviewed.

  13. Productivity cycles of 200-300 years in the Antarctic Peninsula region: Understanding linkages among the sun, atmosphere, oceans, sea ice, and biota

    USGS Publications Warehouse

    Leventer, A.; Domack, E.W.; Ishman, S.E.; Brachfeld, S.; McClennen, C.E.; Manley, P.

    1996-01-01

    Compared to the rest of the world's oceans, high-resolution late Holocene paleoclimatic data from the Southern Ocean are still rare. We present a multiproxy record from a sediment core retrieved from a deep basin on the western side of the Antarctic Peninsula that reveals a dramatic perspective on paleoclimatic changes over the past 3700 yr. Analyses completed include measurement of magnetic susceptibility and granulometry, bed thickness, particle size, percent organic carbon, bulk density, and microscopic evaluation of diatom and benthic foraminiferal assemblages and abundances. Downcore variability of these parameters demonstrates the significance of both short-term cycles, which recur approximately every 200 yr, and longer term events (???2500 yr cycles) that are most likely related to global climatic fluctuations. In the upper 600 cm of the core, lower values of magnetic susceptibility (MS) are correlated with lower bulk density, the presence of thinly laminated units, specific diatom assemblages, and generally higher total organic carbon content. Below 600 cm, magnetic susceptibility is uniformly low, though variability in other parameters continues. The magnetic susceptibility signal is controlled primarily by dilution of ferromagnetic phases with biosiliceous material. This signal may be enhanced further by dissolution of magnetite in the magnetic susceptibility lows (high total organic carbon). The role of variable primary productivity and its relationship to paleoclimate is assessed through the diatom data. In particular, magnetic susceptibility lows are characterized by higher than normal abundances of Chaetoceros resting spores. Corethron criophilum and/or Rhizosolenia spp. also are found, as is a higher ratio of the most common species of Fragilariopsis versus species of Thalassiosira. These assemblages are indicative of periods of high primary productivity driven by the presence of a melt-water stabilized water column. The 200 yr cyclicity noted in

  14. 76 FR 38074 - Airworthiness Directives; The Boeing Company Model 747-100, 747-100B, 747-200B, 747-200C, 747...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-29

    ... for other airplanes. This proposed AD results from reports of multiple adjacent cracks on an airplane..., environmental, and energy aspects of this proposed AD. We will consider all comments received by the closing... post a report summarizing each substantive verbal contact we receive about this proposed AD....

  15. 75 FR 1533 - Airworthiness Directives; The Boeing Company Model 747-200F, 747-200C, 747-400, 747-400D, and 747...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... certain fuselage internal structure (i.e., Sections 42 and 46 fuselage frames, upper deck floor beams... (i.e., Section 41 fuselage frames where they connect to upper deck floor beams, and Section 41... where fatigue cracks can occur. We are issuing this AD to prevent the loss of structural integrity...

  16. 940nm QCW diode laser bars with 70% efficiency at 1 kW output power at 203K: analysis of remaining limits and path to higher efficiency and power at 200K and 300K

    NASA Astrophysics Data System (ADS)

    Frevert, C.; Bugge, F.; Knigge, S.; Ginolas, A.; Erbert, G.; Crump, P.

    2016-03-01

    Both high-energy-class laser facilities and commercial high-energy pulsed laser sources require reliable optical pumps with the highest pulse power and electro-optical efficiency. Although commercial quasi-continuous wave (QCW) diode laser bars reach output powers of 300…500 W further improvements are urgently sought to lower the cost per Watt, improve system performance and reduce overall system complexity. Diode laser bars operating at temperatures of around 200 K show significant advances in performance, and are particularly attractive in systems that use cryogenically cooled solid state lasers. We present the latest results on 940 nm, passively cooled, 4 mm long QCW diode bars which operate under pulse conditions of 1.2 ms, 10 Hz at an output power of 1 kW with efficiency of 70% at 203 K: a two-fold increase in power compared to 300 K, without compromising efficiency. We discuss how custom low-temperature design of the vertical layers can mitigate the limiting factors such as series resistance while sustaining high power levels. We then focus on the remaining obstacles to higher efficiency and power, and use a detailed study of multiple vertical structures to demonstrate that the properties of the active region are a major performance limit. Specifically, one key limit to series resistance is transport in the layers around the active region and the differential internal efficiency is closely correlated to the threshold current. Tailoring the barriers around the active region and reducing transparency current density thus promise bars with increased performance at temperatures of 200 K as well as 300 K.

  17. Plastic substrates for active matrix liquid crystal display incapable of withstanding processing temperature of over 200 C and method of fabrication

    DOEpatents

    Carey, P.G.; Smith, P.M.; Havens, J.H.; Jones, P.

    1999-01-05

    Bright-polarizer-free, active-matrix liquid crystal displays (AMLCDs) are formed on plastic substrates. The primary components of the display are a pixel circuit fabricated on one plastic substrate, an intervening liquid-crystal material, and a counter electrode on a second plastic substrate. The-pixel circuit contains one or more thin-film transistors (TFTs) and either a transparent or reflective pixel electrode manufactured at sufficiently low temperatures to avoid damage to the plastic substrate. Fabrication of the TFTs can be carried out at temperatures less than 100 C. The liquid crystal material is a commercially made nematic curvilinear aligned phase (NCAP) film. The counter electrode is comprised of a plastic substrate coated with a transparent conductor, such as indium-doped tin oxide (ITO). By coupling the active matrix with NCAP, a high-information content can be provided in a bright, fully plastic package. Applications include any low cost portable electronics containing flat displays where ruggedization of the display is desired. 12 figs.

  18. Topographical map series in the Map Room of Institute and Museum of Military History in Budapest, Hungary between 1919-1945: Smaller scale series (1:100,000, 1:200,000, 1:300,000, 1:500,000, 1:750,000) of the territory of Central Europe

    NASA Astrophysics Data System (ADS)

    Jankó, A.; Bánfi, R.

    2009-04-01

    The Royal Hungarian State Mapping Institute kept the smaller scales series of the third military survey of the Austro-Hungarian Monarchy, too, so the scales 1:200,000 and 1:750,000 maps. The results of the supervisions of larger scales were transferred onto these scales, 1:200,000 and 1:750,000 maps, for the territory of Central Europe. In 1943 a scale 1:500,000 aerial map was accomplished, too, for the territory of Pannonian basin. There are many other important series in the Map Room between 1919 and 1945, including the WWII German edition 1:300,000 scale map series of Central Europe and Russia to the Ural Mts.; and a series of scale 1:100,000 for the territory of Poland and Russia between 1939-1940.

  19. The effect of oxygen concentration on the boundary lubricating characteristics of an unformulated C-ether to 300 C

    NASA Technical Reports Server (NTRS)

    Jones, W. R., Jr.

    1973-01-01

    The effect of oxygen concentration on the boundary lubricating characteristics of an unformulated C-ether was studied with the use of a ball-on disk sliding-friction apparatus. Results were compared with those obtained with a polyphenyl ether. Experimental conditions included oxygen concentrations ranging from 20 percent (air) to 0.001 percent (nitrogen), a load of 1 kilogram, a sliding speed of 17 meters per minute, and disk temperatures ranging from 20 to 300 C (77 to 572 F). The C-ether yielded better boundary lubricating characteristics than did the polyphenyl ether in air and nitrogen over most of the temperature range. The C-ether exhibited lower wear at high oxygen levels (10 to 20 percent O2) from 25 to 200 C (77 to 392 F) and at low oxygen levels (0.001 to 1.0 percent O2) from 200 to 300 C (392 to 572 F). Friction polymer was observed around the wear scars of most test specimens. Friction polymer generation and its effect on wear are discussed in light of current theories.

  20. 50 CFR 300.200 - Purpose and scope.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... sharks where the nation has not adopted a regulatory program for the conservation of sharks, comparable..., unreported, or unregulated fishing, reduce bycatch of protected living marine resources, and achieve...

  1. 50 CFR 300.200 - Purpose and scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... sharks where the nation has not adopted a regulatory program for the conservation of sharks, comparable..., unreported, or unregulated fishing, reduce bycatch of protected living marine resources, and achieve...

  2. 2 CFR 200.300 - Statutory and national policy requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... expended and associated programs are implemented in full accordance with U.S. statutory and public policy... discrimination. The Federal awarding agency must communicate to the non-Federal entity all relevant public policy... 2 Grants and Agreements 1 2014-01-01 2014-01-01 false Statutory and national policy...

  3. The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells.

    PubMed

    Brozovic, Anamaria; Duran, George E; Wang, Yan C; Francisco, E Brian; Sikic, Branimir I

    2015-10-01

    We studied the role of miRNA-200 family members in cellular sensitivity to paclitaxel and carboplatin, using two ovarian cancer cell lines, OVCAR-3 and MES-OV, and their paclitaxel resistant variants OVCAR-3/TP and MES-OV/TP. Both resistant variants display a strong epithelial-mesenchymal transition (EMT) phenotype, with marked decreases in expression of miR-200c and miR-141 in OVCAR-3/TP, and down-regulation of all five members of the miR-200 family in MES-OV/TP. Lentiviral transfection of inhibitors of miR-200c or miR-141 in parental OVCAR-3 triggered EMT and rendered the cells resistant to paclitaxel and carboplatin. Conversely, the infection of OVCAR-3/TP cells with retroviral particles carrying the miR-200ab429 and 200c141 clusters triggered a partial mesenchymal to epithelial transition (MET). This partial MET was not sufficient to re-sensitize OVCAR-3/TP cells to paclitaxel. However, the miR-200c/miR-141 cluster transfectants became 6-8x resistant to carboplatin, an unexpected result, whereas miR-200a/miR-200b/miR-429 had no effect. Transfecting the OVCAR-3/TP GFP cells with specific miRNA mimics confirmed these data. MiR-200c and miR-141 mimics conferred resistance to carboplatin in MES-OV/TP cells, similar to OVCAR-3/TP, but sensitized MES-OV to paclitaxel. Several genes involved in balancing oxidative stress were altered in OVCAR-3/TP 200c141 cells compared to controls. The miR-200 family plays major, cell-context dependent roles in regulating EMT and sensitivity to carboplatin and paclitaxel in OVCAR-3 and MES-OV cells.

  4. 75 FR 74668 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-01

    ..., Washington 98124-2207; telephone 206- 544-5000, extension 1, fax 206-766-5680; e-mail me.boecom@boeing.com... certify this proposed regulation: 1. Is not a ``significant regulatory action'' under Executive Order 12866, 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR...

  5. 76 FR 13074 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-10

    ... Register on December 1, 2010 (75 FR 74668, January 18, 2011). That NPRM proposed to require repetitive... Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska... also estimate that it will take about 7 work-hours per product to comply with the detailed...

  6. 75 FR 80738 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-23

    ... identify the part number of the motor operated valve (MOV) actuators of the main and center fuel tanks... NPRM was published in the Federal Register on August 7, 2008 (73 FR 45893). That original NPRM proposed to require doing an inspection to identify the part number of the motor operated valve...

  7. 76 FR 63163 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... (76 FR 2846). That NPRM proposed to require installing foreign object debris (FOD) rubber shields over... (76 FR 2846, January 18, 2011). The National Transportation Safety Board supports the NPRM. Request To... Include Information Notices United Airlines asked that we revise the NPRM (76 FR 2846, January 18,...

  8. 76 FR 2846 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-18

    ... 12866, (2) Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034... airplanes, and wrapping fire-resistant silicone tape around the hydraulic tube for certain other airplanes... an adjacent hydraulic tube, creating a hole in the tube and spraying hydraulic fluid into the...

  9. 76 FR 78138 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-16

    ... structure, and cap sealing certain penetrating fasteners of the main and center fuel tanks. This AD expands... (75 FR 78588, December 16, 2010). We must receive any comments on this AD by January 30, 2012... identified in this AD, contact Boeing Commercial Airplanes, Attention: Data & Services ] Management, P.O....

  10. 75 FR 78596 - Airworthiness Directives; Hawker Beechcraft Corporation Models B200, B200GT, B300, and B300C...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... March 27, 2008, we issued AD 2008-07-10, Amendment 39-15451 (73 FR 18706, April 7, 2008), for certain... Executive Order 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... amends Sec. 39.13 by removing airworthiness directive (AD) 2008-07-10, Amendment 39-15451 (73 FR...

  11. 75 FR 17889 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-08

    ... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will... reports of fuel leakage from the center tank. We are proposing this AD to detect and correct improperly... leaks. On the ground, uncontained fuel leakage could result in pooling, and pooling combined with...

  12. 75 FR 70102 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-17

    ... airplanes. That NPRM was published in the Federal Register on April 8, 2010 (75 FR 17889). That NPRM... Policies and Procedures (44 FR 11034, February 26, 1979), and (3) Will not have a significant economic... each side of the wing center section. This AD results from reports of fuel leakage from the center...

  13. 75 FR 81508 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-28

    ...'' (66 FR 23086, May 7, 2001). In addition to new airworthiness standards for transport airplanes and new... Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic... ground fault interrupter (GFI) relays. For certain other airplanes, this proposed AD would...

  14. 76 FR 24345 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, and -300ER Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-02

    ... December 28, 2010 (75 FR 81508). That NPRM proposed to require, for certain airplanes, replacing certain... Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska... fault interrupter (GFI) relays. For certain other airplanes, this AD requires installing new panels...

  15. 24 CFR 597.300 - HUD action and review of nominations for designation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Housing and Urban Development (Continued) OFFICE OF ASSISTANT SECRETARY FOR COMMUNITY PLANNING AND... and must be accompanied by a strategic plan, as required by § 597.200(c), and the certifications... evaluation. (d) Modification of the strategic plan, boundaries of nominated urban areas, and/or period...

  16. 24 CFR 597.300 - HUD action and review of nominations for designation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... and must be accompanied by a strategic plan, as required by § 597.200(c), and the certifications... evaluation. (d) Modification of the strategic plan, boundaries of nominated urban areas, and/or period during... reasonable modifications of the strategic plan, the proposed boundaries of a nominated urban area, or...

  17. 24 CFR 597.300 - HUD action and review of nominations for designation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... and must be accompanied by a strategic plan, as required by § 597.200(c), and the certifications... evaluation. (d) Modification of the strategic plan, boundaries of nominated urban areas, and/or period during... reasonable modifications of the strategic plan, the proposed boundaries of a nominated urban area, or...

  18. 24 CFR 597.300 - HUD action and review of nominations for designation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... and must be accompanied by a strategic plan, as required by § 597.200(c), and the certifications... evaluation. (d) Modification of the strategic plan, boundaries of nominated urban areas, and/or period during... reasonable modifications of the strategic plan, the proposed boundaries of a nominated urban area, or...

  19. 24 CFR 597.300 - HUD action and review of nominations for designation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... and must be accompanied by a strategic plan, as required by § 597.200(c), and the certifications... evaluation. (d) Modification of the strategic plan, boundaries of nominated urban areas, and/or period during... reasonable modifications of the strategic plan, the proposed boundaries of a nominated urban area, or...

  20. 34 CFR 300.300 - Parental consent.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and Educational Placements Parental Consent § 300.300 Parental consent. (a) Parental consent for initial evaluation. (1)(i) The public agency proposing to conduct an initial evaluation to determine if a child qualifies as...

  1. 34 CFR 300.300 - Parental consent.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and Educational Placements Parental Consent § 300.300 Parental consent. (a) Parental consent for initial evaluation. (1)(i) The public agency proposing to conduct an initial evaluation to determine if a child qualifies as...

  2. Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma

    PubMed Central

    Xie, Xiujie; Piao, Longzhu; Bullock, Brooke N.; Smith, Ashley; Su, Tizhi; Zhang, Manchao; Teknos, Theodoros N.; Arora, Paramjit S.; Pan, Quintin

    2014-01-01

    The incidence of human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) has rapidly increased over the past 30 years prompting the suggestion that an epidemic may be on the horizon. Therefore, there is a clinical need to develop alternate therapeutic strategies to manage the growing number of HPV-positive HNSCC patients. High-risk HPV E6 inactivates p53 through two distinct mechanisms; association with E6AP to degrade p53 and association with p300 to block p300-mediated p53 acetylation and activation. In this study, we determined if targeting the E6-p300 interaction is an effective approach to reactivate p53 in HPV-positive HNSCC. Ectopic expression of the CH1 domain of p300 in HPV-positive HNSCC blocks the association between E6 and p300, increases total and acetylated p53 levels, and enhances p53 transcriptional activity. Moreover, expression of p21, miR-34a, and miR-200c are increased demonstrating functional p53 reactivation. CH1 overexpression in HPV-positive HNSCC has a global anti-cancer effect resulting in a decrease in cell proliferation and clonogenic survival and an increase in apoptosis. The in vivo tumor initiating ability of HPV-positive HNSCC is severely compromised with CH1 overexpression, in part through a reduction in the cancer initiating cell population. A novel small molecule CH1 inhibitor, CH1iB, reactivates p53 and potentiates the anti-cancer activity of cis-platinum in HPV-positive HNSCC cells. Our work shows that CH1 domain inhibitors represent a novel class of p53 reactivation therapeutics for managing HPV-positive HNSCC patients. PMID:23474763

  3. Galaxy NGC 300

    NASA Technical Reports Server (NTRS)

    2003-01-01

    This image of the nearby spiral galaxy NGC 300 was taken by Galaxy Evolution Explorer in a single orbit exposure of 27 minutes on October 10, 2003. NGC 300 lies 7 million light years from our Milky Way galaxy and is one of a group of galaxies in the constellation Sculptor. NGC 300 is often used as a prototype of a spiral galaxy because in optical images it displays flowing spiral arms and a bright central region of older (and thus redder) stars. The Galaxy Evolution Explorer image taken in ultraviolet light shows us that NGC 300 is an efficient star-forming galaxy. The bright blue regions in the Galaxy Evolution Explorer image reveal new stars forming all the way into the nucleus of NGC 300.

  4. 29 CFR 99.200 - Audit requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Audits § 99.200 Audit requirements. (a) Audit required. Non-Federal entities that expend $300,000 or more in a.... Guidance on determining Federal awards expended is provided in § 99.205. (b) Single audit....

  5. To designate the federal building currently known as Federal Office Building 8, located at 200 C Street Southwest in the District of Columbia, as the "Thomas P. O'Neill, Jr. Federal Building".

    THOMAS, 112th Congress

    Rep. Pelosi, Nancy [D-CA-8

    2012-11-27

    11/29/2012 Received in the Senate. (All Actions) Notes: For further action, see S.3687, which became Public Law 112-237 on 12/28/2012. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  6. miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the Zeb2 and Snail1 transcriptional repressor complexes.

    PubMed

    Perdigão-Henriques, R; Petrocca, F; Altschuler, G; Thomas, M P; Le, M T N; Tan, S M; Hide, W; Lieberman, J

    2016-01-14

    The miR-200 family promotes the epithelial state by suppressing the Zeb1/Zeb2 epithelial gene transcriptional repressors. To identify other miR-200-regulated genes, we isolated mRNAs bound to transfected biotinylated miR-200c in mouse breast cancer cells. In all, 520 mRNAs were significantly enriched in miR-200c binding at least twofold. Putative miR-200-regulated genes included Zeb2, enriched 3.5-fold in the pull down. However, Zeb2 knockdown does not fully recapitulate miR-200c overexpression, suggesting that regulating other miR-200 targets contributes to miR-200's enhancement of epithelial gene expression. Candidate genes were highly enriched for miR-200c seed pairing in their 3'UTR and coding sequence and for genes that were downregulated by miR-200c overexpression. Epidermal growth factor receptor and downstream MAPK signaling pathways were the most enriched pathways. Genes whose products mediate transforming growth factor (TGF)-β signaling were also significantly overrepresented, and miR-200 counteracted the suppressive effects of TGF-β and bone morphogenic protein 2 (BMP-2) on epithelial gene expression. miR-200c regulated the 3'UTRs of 12 of 14 putative miR-200c-binding mRNAs tested. The extent of mRNA binding to miR-200c strongly correlated with gene suppression. Twelve targets of miR-200c (Crtap, Fhod1, Smad2, Map3k1, Tob1, Ywhag/14-3-3γ, Ywhab/14-3-3β, Smad5, Zfp36, Xbp1, Mapk12, Snail1) were experimentally validated by identifying their 3'UTR miR-200 recognition elements. Smad2 and Smad5 form a complex with Zeb2 and Ywhab/14-3-3β and Ywhag/14-3-3γ form a complex with Snail1. These complexes that repress transcription assemble on epithelial gene promoters. miR-200 overexpression induced RNA polymerase II localization and reduced Zeb2 and Snail1 binding to epithelial gene promoters. Expression of miR-200-resistant Smad5 modestly, but significantly, reduced epithelial gene induction by miR-200. miR-200 expression and Zeb2 knockdown are known to

  7. 300 AREA URANIUM CONTAMINATION

    SciTech Connect

    BORGHESE JV

    2009-07-02

    {sm_bullet} Uranium fuel production {sm_bullet} Test reactor and separations experiments {sm_bullet} Animal and radiobiology experiments conducted at the. 331 Laboratory Complex {sm_bullet} .Deactivation, decontamination, decommissioning,. and demolition of 300 Area facilities

  8. H-200 Plus Five.

    ERIC Educational Resources Information Center

    Ramirez, Alfonso R.

    Project H-200 is a series of English-as-a-second-language (ESL) lessons for the primary grades. To supplement direct language instruction by the Project H-200 classroom teacher, two mechanical aids have been devised. These units are designed to reinforce the language patterns that the children learn in the daily lesson. One type projects a…

  9. Physics 300 Provincial Examination.

    ERIC Educational Resources Information Center

    Manitoba Dept. of Education and Training, Winnipeg.

    This document consists of the physics 300 provincial examination (English version), a separate "provincial summary report" on the results of giving the test, and a separate French language version of the examination. This physics examination contains a 53-item multiple choice section and an 12 item free response section. Subsections of the test…

  10. 34 CFR 300.801-300.802 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false 300.801-300.802 Section 300.801-300.802 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN...

  11. 300 Area Disturbance Report

    SciTech Connect

    LL Hale; MK Wright; NA Cadoret

    1999-01-07

    The objective of this study was to define areas of previous disturbance in the 300 Area of the U.S. Department of Energy (DOE) Hanford Site to eliminate these areas from the cultural resource review process, reduce cultural resource monitoring costs, and allow cultural resource specialists to focus on areas where subsurface disturbance is minimal or nonexistent. Research into available sources suggests that impacts from excavations have been significant wherever the following construction activities have occurred: building basements and pits, waste ponds, burial grounds, trenches, installation of subsurface pipelines, power poles, water hydrants, and well construction. Beyond the areas just mentioned, substrates in the' 300 Area consist of a complex, multidimen- sional mosaic composed of undisturbed stratigraphy, backfill, and disturbed sediments; Four Geographic Information System (GIS) maps were created to display known areas of disturbance in the 300 Area. These maps contain information gleaned from a variety of sources, but the primary sources include the Hanford GIS database system, engineer drawings, and historic maps. In addition to these maps, several assumptions can be made about areas of disturbance in the 300 Area as a result of this study: o o Buried pipelines are not always located where they are mapped. As a result, cultural resource monitors or specialists should not depend on maps depicting subsurface pipelines for accurate locations of previous disturbance. Temporary roads built in the early 1940s were placed on layers of sand and gravel 8 to 12 in. thick. Given this information, it is likely that substrates beneath these early roads are only minimally disturbed. Building foundations ranged from concrete slabs no more than 6 to 8 in. thick to deeply excavated pits and basements. Buildings constructed with slab foundations are more numerous than may be expected, and minimally disturbed substrates may be expected in these locations. Historic black

  12. CYBER 200 Applications Seminar

    NASA Technical Reports Server (NTRS)

    Gary, J. P. (Compiler)

    1984-01-01

    Applications suited for the CYBER 200 digital computer are discussed. Various areas of application including meteorology, algorithms, fluid dynamics, monte carlo methods, petroleum, electronic circuit simulation, biochemistry, lattice gauge theory, economics and ray tracing are discussed.

  13. Tracker 300 Software

    SciTech Connect

    Wysor, R. Wes

    2006-01-12

    The Tracker300 software is downloaded to an off-the-shelf product called RCM3400/RCM3410 made by Rabbit Semiconductor. The software is a closed loop control which computes the sun's position and provides stability compensation. Using the RCM3400/RCM3410 module, the software stores and retrieves parameters from the onboard flash. The software also allows for communication with a host. It will allow the parameters to be downloaded or uploaded, it will show the status of the controller, it will provide real-time feedback, and it will send command acknowledgements. The software will capture the GPS response and ensure the internal clock is set correctly.

  14. Status of EXO-200

    SciTech Connect

    Ackerman, Nicole; /SLAC

    2011-12-06

    EXO-200 is the first phase of the Enriched Xenon Observatory (EXO) experiment, which searches for neutrinoless double beta decay in {sup 136}Xe to measure the mass and probe the Majorana nature of the neutrino. EXO-200 consists of 200 kg of liquid Xe enriched to 80% in {sup 136}Xe in an ultra-low background TPC. Energy resolution is enhanced through the simultaneous collection of scintillation light using Large Area Avalanche Photodiodes (LAAPD's) and ionization charge. It is being installed at the WIPP site in New Mexico, which provides a 2000 meter water-equivalent overburden. EXO-200 will begin taking data in 2009, with the expected two-year sensitivity to the half-life for neutrinoless double beta decay of 6.4 x 10{sup 25} years. According to the most recent nuclear matrix element calculations, this corresponds to an effective Majorana neutrino mass of 0.13 to 0.19 eV. It will also measure the two neutrino mode for the first time in {sup 136}Xe.

  15. Tracker 300 Software

    2006-01-12

    The Tracker300 software is downloaded to an off-the-shelf product called RCM3400/RCM3410 made by Rabbit Semiconductor. The software is a closed loop control which computes the sun's position and provides stability compensation. Using the RCM3400/RCM3410 module, the software stores and retrieves parameters from the onboard flash. The software also allows for communication with a host. It will allow the parameters to be downloaded or uploaded, it will show the status of the controller, it will providemore » real-time feedback, and it will send command acknowledgements. The software will capture the GPS response and ensure the internal clock is set correctly.« less

  16. Microeconomics of 300-mm process module control

    NASA Astrophysics Data System (ADS)

    Monahan, Kevin M.; Chatterjee, Arun K.; Falessi, Georges; Levy, Ady; Stoller, Meryl D.

    2001-08-01

    Simple microeconomic models that directly link metrology, yield, and profitability are rare or non-existent. In this work, we validate and apply such a model. Using a small number of input parameters, we explain current yield management practices in 200 mm factories. The model is then used to extrapolate requirements for 300 mm factories, including the impact of simultaneous technology transitions to 130nm lithography and integrated metrology. To support our conclusions, we use examples relevant to factory-wide photo module control.

  17. 17 CFR 200.30-11-200.30-12 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false 200.30-11-200.30-12 Section 200.30-11-200.30-12 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General...

  18. 75 FR 39814 - Airworthiness Directives; Airbus Model A330-200 and -300, and Model A340-200, -300, -500 and -600...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... products. That NPRM was published in the Federal Register on December 29, 2009 (74 FR 68737). That NPRM... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or..., -342 and -343 airplanes, all serial numbers, except those on which Airbus modification 55590 has...

  19. 75 FR 15353 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes, and A340-200, -300...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... 13, 2009 (74 FR 1649). That earlier NPRM proposed to correct an unsafe condition for the products... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034... describes the unsafe condition as: Several cases of corrosion and damage on the Down Drive Shafts...

  20. 75 FR 4710 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes and A340-200, -300...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-29

    ... Portal: Go to http://www.regulations.gov . Follow the instructions for submitting comments. Fax: (202... section. Include ``Docket No. FAA-2009-1212; Directorate Identifier 2008-NM-167-AD'' at the beginning of... this proposed AD. Discussion On February 22, 2007, we issued AD 2007-05-08, Amendment 39-14969 (72...

  1. 75 FR 39790 - Airworthiness Directives; Airbus Model A330-200 and -300 Airplanes and Model A340-200, -300, -500...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-13

    ... by reference of certain publications listed in this AD as of August 17, 2010. On June 26, 2007 (72 FR... NPRM was published in the Federal Register on September 25, 2009 (74 FR 48872), and proposed to supersede AD 2007-18-04, Amendment 39- 15184 (72 FR 50042, August 30, 2007). That NPRM proposed to...

  2. 75 FR 54536 - Airworthiness Directives; Airbus Model A330-200 and -300 and A340-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-08

    ...--Airworthiness Office--EAL, 1 Rond Point Maurice Bellonte, 31707 Blagnac Cedex, France; telephone +33 5 61 93 36..., Amendment 39-14329 (70 FR 59263, October 12, 2005). That AD required actions intended to address an unsafe... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive...

  3. 76 FR 6543 - Airworthiness Directives; Airbus Model A330-200 and -300 and A340-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... publications listed in this AD as of March 14, 2011. On November 16, 2005 (70 FR 59263, October 12, 2005), the... Register on September 8, 2010 (75 FR 54536), and proposed to supersede AD 2005-20-32, Amendment 39- 14329 (70 FR 59263, October 12, 2005). That NPRM proposed to correct an unsafe condition for the...

  4. 75 FR 12657 - Airworthiness Directives; The Boeing Company Model 777-200, -200LR, -300, -300ER, and 777F Series...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-17

    ... Policies and Procedures (44 FR 11034, February 26, 1979), and (3) Will not have a significant economic... the takeoff, and targets a velocity to maximize climbout performance. FAA's Determination...

  5. 75 FR 42589 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes, and A340-200, -300...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... specified products. That supplemental NPRM was published in the Federal Register on March 29, 2010 (75 FR... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... the date of issuance of the original French standard airworthiness certificate or the date of...

  6. 77 FR 26663 - Airworthiness Directives; The Boeing Company Model 767-200, -300, -300F, and -400ER Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-07

    ... paragraphs (g) and (h) of this AD, as applicable. (p) Related Information For more information about this AD... bulkhead at body station 955 and the skin; and follow- on and corrective actions. This new AD expands the... incorporation by reference of certain other publications listed in this AD as of November 1, 2004 (69 FR...

  7. 76 FR 10288 - Airworthiness Directives; The Boeing Company Model 767-200, -300, -300F, and -400ER Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... straps on 41 airplanes; we have also received a report of a crack found in the ``T'' fitting that... necessary. We are proposing this AD to detect and correct fatigue cracking or corrosion of the fail-safe straps and the ``T'' fittings, which could result in cracking of adjacent structure and...

  8. 78 FR 52107 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Rechargeable Lithium...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-22

    ... April 11, 2000 (65 FR 19477-19478), as well as at http://DocketsInfo.dot.gov/ gov/. Docket: Background... Series Airplanes; Rechargeable Lithium Ion Batteries and Battery Systems AGENCY: Federal Aviation... lithium ion batteries and battery system that will be used on an International Communications Group...

  9. 76 FR 13534 - Airworthiness Directives; The Boeing Company Model 767-200, -300, -300F, and -400ER Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ... proposed AD. Discussion On October 19, 2009, we issued AD 2009-22-13, amendment 39-16066 (74 FR 55755... ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3... amendment 39-16066 (74 FR 55755, October 29, 2009) and adding the following new AD: The Boeing...

  10. 78 FR 68986 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... and connectivity capabilities of the airplane's onboard network computer systems, which may allow access to or by external computer systems and networks. This onboard network system will be composed of a... following novel or unusual design features: An onboard computer network system, and a network...

  11. 78 FR 68985 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-18

    ... and connectivity of the passenger service computer network systems to the airplane critical systems and data networks. This onboard network system will be composed of a network file server, a network... computer network system, and a network extension device. The network extension device will improve...

  12. 75 FR 15322 - Airworthiness Directives; The Boeing Company Model 767-200, -300, and -300F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-29

    ... center wing tank. The center wing tank has been identified as a high flammability tank under the Special... reviews conducted by the manufacturer. We are issuing this AD to prevent the center tank fuel densitometer from overheating and becoming a potential ignition source inside the center fuel tank, which,...

  13. 75 FR 78588 - Airworthiness Directives; The Boeing Company Model 777-200, -300, and -300ER Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-16

    ... fasteners of the main and center fuel tanks. This AD results from fuel system reviews conducted by the..., contact Boeing Commercial Airplanes, Attention: Data & Services Management, P.O. Box 3707, MC 2H-65... supplemental NPRM was published in the Federal Register on June 18, 2010 (75 FR 34663). The original NPRM...

  14. 75 FR 34663 - Airworthiness Directives; The Boeing Company Model 777-200, -300, and -300ER Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ... fasteners of the main and center fuel tanks. The original NPRM resulted from fuel system reviews conducted... proposed AD, contact Boeing Commercial Airplanes, Attention: Data & Services Management, P. O. Box 3707, MC... series airplanes. That original NPRM was published in the Federal Register on January 29, 2007 (72...

  15. 75 FR 3656 - Airworthiness Directives; The Boeing Company Model 767-200, -300, and -300F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-22

    ... through due to inadvertent electrical current from a short circuit in an adjacent audio select panel. We are proposing this AD to prevent inadvertent electrical current, which can cause the low-pressure flex... system that burned through due to inadvertent electrical current from a short circuit in an...

  16. 75 FR 47180 - Airworthiness Directives; The Boeing Company Model 767-200, -300, and -300F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-05

    ... flex-hoses of the flightcrew oxygen system that burned through due to inadvertent electrical current... electrical current, which can cause the low-pressure flex- hoses used in the flightcrew and supernumerary... to inadvertent electrical current from a short circuit in an adjacent audio select panel. We...

  17. 76 FR 52899 - Airworthiness Directives; The Boeing Company Model 767-200, -300, and -300F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-24

    ... Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska, and (4) Will... temperature control system (CACTCS), and performing an operational test of the cooling pack fire suppression... relay installed on a panel as part of the cabin air conditioning and temperature control system...

  18. 75 FR 42592 - Airworthiness Directives; The Boeing Company Model 767-200, -300, and -300F Series Airplanes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... 13, 2005, we issued AD 2005-19-23, amendment 39-14288 (70 FR 55519, September 22, 2005). That AD... (65 Certain Boeing Model 767-54A0094 Repetitive inspections FR 18883, April 10, 2000). 767 series...-16-12, amendment 39-13768 (69 Certain Boeing Model 767-54-0069, 767-54- Modification of the FR...

  19. 75 FR 5677 - Airworthiness Directives; The Boeing Company Model 767-200, -300, and -300F Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... publication listed in the AD as of March 5, 2001 (66 FR 8085, January 29, 2001). The Director of the Federal... as of October 17, 2000 (65 FR 58641, October 2, 2000). We must receive any comments on this AD by.... SUPPLEMENTARY INFORMATION: Discussion On January 22, 2003, we issued AD 2003-03-02, amendment 39-13026 (68...

  20. 78 FR 70849 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... the EFB architecture and existing airplane network systems. The applicable airworthiness regulations..., software-configurable avionics, and fiber-optic avionics networks. The proposed Class 3 EFB architecture is... existing regulations and guidance material did not anticipate this type of system architecture...

  1. 78 FR 70848 - Special Conditions: Boeing Model 777-200, -300, and -300ER Series Airplanes; Aircraft Electronic...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-27

    ... the EFB architecture and existing airplane network systems. The applicable airworthiness regulations..., software-configurable avionics, and fiber-optic avionics networks. The proposed Class 3 EFB architecture is... existing regulations and guidance material did not anticipate this type of system architecture...

  2. 76 FR 22305 - Airworthiness Directives; The Boeing Company Model 777-200, -300, and -300ER Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-21

    ... products. That NPRM published in the Federal Register on December 30, 2010 (75 FR 82337). That NPRM... Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska... (AIMS-2) software in the AIMS-2 hardware; and making certain wiring changes. This AD was prompted...

  3. 75 FR 82337 - Airworthiness Directives; The Boeing Company Model 777-200, -300, and -300ER Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-30

    ... System Design Review, Flammability Reduction and Maintenance and Inspection Requirements'' (66 FR 23086... 12866, (2) Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034...; installing airplane information management system 2 (AIMS-2) software in the AIMS-2 hardware; and...

  4. 76 FR 13541 - Airworthiness Directives; The Boeing Company Model 757-200, -200CB, and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ...-11266 (64 FR 45436, August 20, 1999), which was based on Boeing Service Bulletin 757-25-0182, Revision 1... Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska, and (4) Will... the bearings and lockbase retainer in the door latch assembly, relocating and adjusting of the...

  5. 76 FR 1351 - Airworthiness Directives; The Boeing Company Model 757-200, -200CB, and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-10

    ... Executive Order 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... of the crown skin panel along the chem- milled step at stringers S-4 left and S-4 right, from... the lap joint at stringer 4L (left) of the chem-milled step. The airplane had accumulated 24,631...

  6. MicroRNA-200b Impacts Breast Cancer Cell Migration and Invasion by Regulating Ezrin-Radixin-Moesin.

    PubMed

    Hong, Hong; Yu, Haizhong; Yuan, Jianfen; Guo, Chunyan; Cao, Hongyan; Li, Weibing; Xiao, Chunhong

    2016-01-01

    BACKGROUND Ezrin-radixin-moesin (ERM) plays an important role in multiple links of tumors. It also involved in breast cancer invasion and metastasis, and might be a potential biomarker of breast cancer. Another study suggested that ERM expression was regulated directly by miR-200c, and had a critical role in miR-200c suppressing cell migration. This study aimed to investigate the effect of miR-200b on ERM expression in a breast cancer cell line and its influence on invasion and metastasis ability in vitro. MATERIAL AND METHODS Breast cancer cell lines MCF-7 and MDA-MB-231 with different metastatic potentials were selected as a model. MiR-200b overexpression or inhibition was achieved by Lipofectamine™ 2000-mediated miRNA transfection. RT-PCR was used to test miR-200b level, while Western blot was selected to detect ERM protein expression. Wound healing assay and Transwell assay were performed to determine cell migration and invasion ability. RESULTS RT-PCR revealed that miR-200b level in MDA-MB-231 was obviously lower than that in MCF-7, while Western blot analysis showed that ERM expression was significantly higher. MiR-200b inhibition by transfection in MCF-7 markedly decreased miR-200b level, elevated ERM expression, and enhanced cell migration and invasion. MiR-200b overexpression in MDA-MB-231 obviously increased miR-200b level, reduced ERM expression, and weakened cell migration and invasion. CONCLUSIONS MiR-200b participates in breast cancer cell migration and invasion through regulating ERM in MCF-7 and MDA-MB-231. PMID:27276064

  7. 24 CFR 200.200 - What is the Appraiser Roster?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false What is the Appraiser Roster? 200... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Appraiser Roster § 200.200 What is the... appraiser from this list for the appraisal of a property that is to be the security for an...

  8. 24 CFR 200.200 - What is the Appraiser Roster?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false What is the Appraiser Roster? 200... HOUSING AND URBAN DEVELOPMENT GENERAL INTRODUCTION TO FHA PROGRAMS Appraiser Roster § 200.200 What is the... appraiser from this list for the appraisal of a property that is to be the security for an...

  9. MicroRNA-200 Family Modulation in Distinct Breast Cancer Phenotypes

    PubMed Central

    Sarrió, David; Romero-Pérez, Laura; López-García, María Ángeles; Vieites, Begoña; Biscuola, Michele; Ramiro-Fuentes, Susana; Isacke, Clare M.; Palacios, José

    2012-01-01

    The epithelial to mesenchymal transition (EMT) contributes to tumor invasion and metastasis in a variety of cancer types. In human breast cancer, gene expression studies have determined that basal-B/claudin-low and metaplastic cancers exhibit EMT-related characteristics, but the molecular mechanisms underlying this observation are unknown. As the family of miR-200 microRNAs has been shown to regulate EMT in normal tissues and cancer, here we evaluated whether the expression of the miR-200 family (miR-200f) and their epigenetic state correlate with EMT features in human breast carcinomas. We analyzed by qRT-PCR the expression of miR-200f members and various EMT-transcriptional inducers in a series of 70 breast cancers comprising an array of phenotypic subtypes: estrogen receptor positive (ER+), HER2 positive (HER2+), and triple negative (TN), including a subset of metaplastic breast carcinomas (MBCs) with sarcomatous (homologous or heterologous) differentiation. No MBCs with squamous differentiation were included. The DNA methylation status of miR-200f loci in tumor samples were inspected using Sequenom MassArray® MALDI-TOF platform. We also used two non-tumorigenic breast basal cell lines that spontaneously undergo EMT to study the modulation of miR-200f expression during EMT in vitro. We demonstrate that miR-200f is strongly decreased in MBCs compared with other cancer types. TN and HER2+ breast cancers also exhibited lower miR-200f expression than ER+ tumors. Significantly, the decreased miR-200f expression found in MBCs is accompanied by an increase in the expression levels of EMT-transcriptional inducers, and hypermethylation of the miR-200c-141 locus. Similar to tumor samples, we demonstrated that downregulation of miR-200f and hypermethylation of the miR-200c-141 locus, together with upregulation of EMT-transcriptional inducers also occur in an in vitro cellular model of spontaneous EMT. Thus, the expression and methylation status of miR-200f could be used

  10. Rabbit CD200R binds host CD200 but not CD200-like proteins from poxviruses

    PubMed Central

    Akkaya, Munir; Kwong, Lai-Shan; Akkaya, Erdem; Hatherley, Deborah; Barclay, A. Neil

    2016-01-01

    CD200 is a widely distributed membrane protein that gives inhibitory signals through its receptor (CD200R) on myeloid cells. CD200 has been acquired by herpesviruses where it has been shown to interact with host CD200R and downmodulate the immune system. It has been hypothesized that poxviruses have acquired CD200; but the potential orthologues show less similarity to their hosts. Myxoma virus M141 protein is a potential CD200 orthologue with a potent immune modulatory function in rabbits. Here, we characterized the rabbit CD200, CD200R and tested the CD200-like sequences for binding CD200R. No binding could be detected using soluble recombinant proteins, full length protein expressed on cells or myxoma virus infected cells. Finally, using knockdown models, we showed that the inhibitory effect of M141 on RAW 264.7 cells upon myxoma virus infection is not due to CD200R. We conclude that the rabbit poxvirus CD200-like proteins cause immunomodulation without utilizing CD200R. PMID:26590792

  11. Rabbit CD200R binds host CD200 but not CD200-like proteins from poxviruses.

    PubMed

    Akkaya, Munir; Kwong, Lai-Shan; Akkaya, Erdem; Hatherley, Deborah; Barclay, A Neil

    2016-01-15

    CD200 is a widely distributed membrane protein that gives inhibitory signals through its receptor (CD200R) on myeloid cells. CD200 has been acquired by herpesviruses where it has been shown to interact with host CD200R and downmodulate the immune system. It has been hypothesized that poxviruses have acquired CD200; but the potential orthologues show less similarity to their hosts. Myxoma virus M141 protein is a potential CD200 orthologue with a potent immune modulatory function in rabbits. Here, we characterized the rabbit CD200, CD200R and tested the CD200-like sequences for binding CD200R. No binding could be detected using soluble recombinant proteins, full length protein expressed on cells or myxoma virus infected cells. Finally, using knockdown models, we showed that the inhibitory effect of M141 on RAW 264.7 cells upon myxoma virus infection is not due to CD200R. We conclude that the rabbit poxvirus CD200-like proteins cause immunomodulation without utilizing CD200R. PMID:26590792

  12. Hanford 200 Areas Development Plan

    SciTech Connect

    Rinne, C.A.; Daly, K.S.

    1993-08-01

    The purpose of the Hanford 200 Areas Development Plan (Development Plan) is to guide the physical development of the 200 Areas (which refers to the 200 East Area, 200 West Area, and 200 Area Corridor, located between the 200 East and 200 West Areas) in accordance with US Department of Energy (DOE) Order 4320.lB (DOE 1991a) by performing the following: Establishing a land-use plan and setting land-use categories that meet the needs of existing and proposed activities. Coordinating existing, 5-year, and long-range development plans and guiding growth in accordance with those plans. Establishing development guidelines to encourage cost-effective development and minimize conflicts between adjacent activities. Identifying site development issues that need further analysis. Integrating program plans with development plans to ensure a logical progression of development. Coordinate DOE plans with other agencies [(i.e., Washington State Department of Ecology (Ecology) and US Environmental Protection Agency (EPA)]. Being a support document to the Hanford Site Development Plan (DOE-RL 1990a) (parent document) and providing technical site information relative to the 200 Areas.

  13. Ice core profiles of saturated fatty acids (C12:0-C30:0) and oleic acid (C18:1) from southern Alaska since 1734 AD: A link to climate change in the Northern Hemisphere

    NASA Astrophysics Data System (ADS)

    Pokhrel, Ambarish; Kawamura, Kimitaka; Seki, Osamu; Matoba, Sumio; Shiraiwa, Takayuki

    2015-01-01

    An ice core drilled at Aurora Peak in southeast Alaska was analyzed for homologous series of straight chain fatty acids (C12:0-C30:0) including unsaturated fatty acid (oleic acid) using gas chromatography (GC/FID) and GC/mass spectrometry (GC/MS). Molecular distributions of fatty acids are characterized by even carbon number predominance with a peak at palmitic acid (C16:0, av. 20.3 ± SD. 29.8 ng/g-ice) followed by oleic acid (C18:1, 19.6 ± 38.6 ng/g-ice) and myristic acid (C14:0, 15.3 ± 21.9 ng/g-ice). The historical trends of short-chain fatty acids, together with correlation analysis with inorganic ions and organic tracers suggest that short-chain fatty acids (except for C12:0 and C15:0) were mainly derived from sea surface micro layers through bubble bursting mechanism and transported over the glacier through the atmosphere. This atmospheric transport process is suggested to be linked with Kamchatka ice core δD record from Northeast Asia and Greenland Temperature Anomaly (GTA). In contrast, long-chain fatty acids (C20:0-C30:0) are originated from terrestrial higher plants, soil organic matter and dusts, which are also linked with GTA. Hence, this study suggests that Alaskan fatty acids are strongly influenced by Pacific Decadal Oscillation/North Pacific Gyre Oscillation and/or extra tropical North Pacific surface climate and Arctic oscillation. We also found that decadal scale variability of C18:1/C18:0 ratios in the Aurora Peak ice core correlate with the Kamchatka ice core δD, which reflects climate oscillations in the North Pacific. This study suggests that photochemical aging of organic aerosols could be controlled by climate periodicity.

  14. 50 CFR 300.39 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Pacific Tuna Fisheries § 300.39 Exceptions. (a) The prohibitions of § 300.38 and the licensing requirements of § 300.32 do not apply to fishing for albacore tuna by vessels using the trolling method or...

  15. Quarterly environmental radiological survey summary. Fourth quarter, 1995 100, 200, 300, and 600 Areas

    SciTech Connect

    McKinney, S.M.; Markes, B.M.

    1996-01-01

    This report provides a summary of the radiological surveys performed in support of the operational environmental monitoring program at the Hanford Site. The Fourth Quarter 1995 survey results and the status of actions required from current and past reports are described.

  16. 75 FR 38945 - Airworthiness Directives; The Boeing Company Model 777-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-07

    ... Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic impact, positive or... software in the cabin management system, and loading new software into the mass memory card. This proposed... follows: At the cabin system control panel (CSCP), remove the installed mass memory card (MMC)...

  17. 76 FR 12617 - Airworthiness Directives; The Boeing Company Model 777-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-08

    ... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979), and 3. Will...-essential electrical systems through a switch in the flight compartment in the event of smoke or flames. In the event of smoke or flames in the airplane flight deck or passenger cabin, the...

  18. 76 FR 6578 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-07

    ... Federal Register on August 4, 2010 (75 FR 46861). The original NPRM (75 FR 4710, January 29, 2010... Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic.... 106(g), 40113, 44701. Sec. 39.13 2. The FAA amends Sec. 39.13 by removing Amendment 39-14969 (72...

  19. 76 FR 53303 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-26

    ... reference of a certain other publication listed in this AD as of June 7, 2006 (71 FR 25919, May 3, 2006... (76 FR 15867), and proposed to supersede AD 2006-09-07, Amendment 39-14577 (71 FR 25919, May 3, 2006... products of U.S. registry. The actions that are required by AD 2006-09-07, Amendment 39-14577 (71 FR...

  20. 76 FR 37255 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-27

    ... reference of a certain other publication listed in this AD as of April 9, 2007 (72 FR 9658, March 5, 2007... on February 7, 2011 (76 FR 6578), and proposed to supersede AD 2007-05-08, Amendment 39-14969 (72 FR..., 2. Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034,...

  1. Quarterly Environmental Radiological Survey Summary Third Quarter 1998, 100, 200, 300, and 600 Areas

    SciTech Connect

    MCKINNEY, S.M.

    1998-10-27

    This report provides a summary of the radiological surveys performed in support of near-facility environmental monitoring at the Hanford Site. The Third Quarter 1998 survey results and the status of actions required are summarized: (1) All of the eighty-five environmental radiological surveys scheduled during July, August and September were performed as planned. Fifty-one of the surveys were conducted at Project Hanford Management Contractors (PHMC) sites and thirty-four at Environmental Restoration Contractor (ERC) sites. Contamination above background levels was found at seventeen of the PHMC waste sites and two of the ERC waste sites. Contamination levels as high >1,000,000 disintegrations per minute (dpm) per 100 cm{sup 2} were reported. Of these contaminated surveys nine were in Underground Radioactive Material (URM) areas, three were in unposted areas and seven were in contamination areas. The contamination found within four of the URM and three of the CA areas was immediately cleaned up and no further action was required. The remaining five URM and two unposted sites were posted and along with the five CA sites will require remediation. Radiological Problem Reports (RPR's) were issued and the sites were turned over to the landlord for further action as required. (2) During the second quarter of 1998, 1.2 hectares (3.0 acres) were stabilized and radiologically down posted from Contamination Area (CA)/Soil Contamination (SC) to URM. (3) Four hectares (10 acres) located south and west of B-Plant were posted as a radiological buffer area as a result of a contamination spread. This off-normal occurrence is currently being investigated. (4) Four Surveillance Compliance Inspection Reports (SCIRs) remained open and had not been resolved. Tank Farms Operations has responsibility for the unresolved SCIRs.

  2. 76 FR 62661 - Airworthiness Directives; The Boeing Company Model 767-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-11

    ... forward lower lobe of the forward cargo compartment and the potential for water to enter into the... forward lower lobe in the forward cargo compartment. This proposed AD was prompted by reports of water... water from accumulating in the forward lower lobe of the forward cargo compartment and entering...

  3. Quarterly environmental radiological survey summary - second quarter 1997 100, 200, 300, and 600 areas

    SciTech Connect

    McKinney, S.M.; Marks, B.M.

    1997-07-22

    This report provides a summary of the radiological surveys performed in support of near-facility environmental monitoring at the Hanford Site. The Second Quarter 1997 survey results and the status of actions required are summarized below: All of the routine environmental radiological surveys scheduled during April, May, and June 1997, were performed as planned with the exception of UN-216-E-9. This site was not surveyed as stabilization activities were in progress. The sites scheduled for the Environmental Restorations Contractor (ERC) team were switched with those identified for the third quarter as there was a conflict with vegetation management activities.

  4. 76 FR 18038 - Airworthiness Directives; Airbus Model A340-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034..., could result in heavy buffet at low speed, or could significantly reduce take off performance [and..., particularly during the take-off or go around, could result in heavy buffet at low speed, or...

  5. 76 FR 69685 - Airworthiness Directives; The Boeing Company Model 767-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-09

    ... filler(s) between the frame and stub-beam, and measuring for filler thickness if necessary; and an open...-condition detailed and HFEC 7 work-hours x $85 per $0 $595. inspections and measurement. hour = $595 per... Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska, and (4)...

  6. Quarterly environmental radiological survey summary. Third quarter 1995 100, 200, 300, and 600 Areas

    SciTech Connect

    McKinney, S.M.; Markes, B.M.

    1995-09-01

    Routine radiological surveys are part of the near-facility environmental monitoring program which monitors and helps direct the reduction of the radiologically controlled areas at the Hanford Site. The routine radiological surveys are performed by the Southern Area Remediation Support Group and the Site Surveillance Radiological Control Group as directed by Near-Field Monitoring. The surveys included in this program consist of inactive waste sites; outdoor radiological control areas; tank farm perimeters and associated diversion boxes, lift stations, and vent stations; perimeters of active or uncovered waste sites such as burial grounds, retention basins, ponds, process trenches, and ditches; and road and rail surfaces. This report provides a summary of the radiological surveys performed during the Third Quarter of 1995. The status of corrective actions required from current and past reports are also discussed.

  7. Quarterly environmental radiological survey summary, first quarter 1998: 100, 200, 300, and 600 areas

    SciTech Connect

    McKinney, S.M.

    1998-04-27

    Routine radiological surveys are part of near-facility environmental monitoring, which monitors and helps direct the reduction of the radiological areas at the Hanford Site. The routine radiological surveys are performed by the Southern Area Remediation Support Group and the Site Support Services Radiological Control Group as directed by Environmental Monitoring and Investigations. The surveys performed have included inactive waste sites; outdoor radiological control areas; tank farm perimeters and associated diversion boxes, lift stations, and vent stations; perimeters of active or uncovered waste sites such as burial grounds, retention basins, ponds, process trenches, and ditches; underground pipelines; and road and rail surfaces. This report provides a summary of the radiological surveys performed in support of near-facility environmental monitoring at the Hanford Site during the first quarter 1998. The survey results and the status of actions required are also discussed. A waste site survey schedule, Routine Environmental Monitoring Schedule, Calendar year 1998, HNF-SP-0098-9, was developed by Environmental Monitoring and Investigations working with the Southern Area Remediation Support Group and the Site Support Services Radiological Control Group. Environmental Monitoring and Investigations reviews the radiological survey reports and files a copy for historical purposes and reference. Radiological conditions are tracked and trends noted. All sites are surveyed at least once each year. The survey frequencies for particular sites are based on site history, 1,551 radiological conditions, and general maintenance. Special surveys may be conducted at irregular frequencies if conditions warrant (e.g., growth of deep-rooted vegetation is noted at a waste site). Radiological surveys are conducted to detect surface contamination and document changes in vegetation growth, biological intrusion, erosion, and general site maintenance conditions. Survey data are compared with standards identified in HSRCM-1, Hanford Site Radiological Control Manual, as well as previous surveys to recognize possible trends, assess environmental impacts, and help determine where corrective actions are needed. Landlords of the sites found out of compliance with HSRCN-1 may be issued a Radiological Problem Report (RPR) from the appropriate radiological Control Group. Open Surveillance Compliance Inspection Reports (SCIRS) are listed. Surveillance of the active nuclear facilities and inside the tank farms is the responsibility of the facility. These radiological surveys are to determine surface radiological conditions and do not constitute a release survey. Therefore, surveys that detect no contamination in radiological areas do not release the site from control but may result in a posting status change.

  8. Quarterly environmental radiological survey summary second quarter 1996 100, 200, 300 and 600 areas

    SciTech Connect

    Dorian, J.J., Westinghouse Hanford

    1996-07-26

    This report provides a summary of the radiological surveys performed in support of the operational environmental monitoring program at the Hanford Site. The Second Quarter 1996 survey results and the status of actions required from current and past reports are summarized below: All the routine environmental radiological surveys scheduled during April, May, and June 1996 were completed. One Hundred twenty- five environmental radiological surveys were performed during the second quarter of 1996, twenty nine at the active waste sites and ninety six at the inactive waste sites. Contamination above background levels Wag found at three of the active waste sites and fifteen of the inactive waste sites. Contamination levels as high as 65,000 disintegrations per minute (dpm) were reported. Of these contaminated surveys seven were in Underground Radioactive Material (URM) areas and one was in an unposted area. The contamination found within three of the URM areas was immediately cleaned up and no further action was required. In the remaining four sites the areas were posted and will require decontamination. At the site where there was no posting, the contamination was below action levels, however, Site Support Services was notified. Radiological Problem Reports (RPR`s) were issued and the sites were turned over to the landlord for further action if required. During the second quarter 1996, 0. 7 hectares (1.7 acres) were stabilized and radiologically down posted from Surface Contamination (SC) to URM. No Compliance Assessment Reports (CARS) were issued for sites found out of compliance with standards identified in WHC-CM-7-5, Environmental Compliance. No Surveillance Compliance/Inspection Reports (SCIR) were closed during the Second Quarter of 1996. Five open SCIRB had not been resolved.

  9. Quarterly environmental radiological survey summary first quarter 1996 100, 200, 300, and 600 areas

    SciTech Connect

    Dorian, J.J.

    1996-04-19

    This report provides a summary of the radiological surveys performed in support of the operational environmental monitoring program at the Hanford Site. The First Quarter 1996 survey results and the status of actions required from current and past reports are summarized: All the routine environmental radiological surveys scheduled during January, February, and March 1996 were completed. One hundred four environmental radiological surveys were performed during the first quarter of 1996, thirty at the active waste sites and seventy four at the inactive waste sites. Contamination above background levels was found at six of the active waste sites and eight of the inactive waste sites. Contamination levels as high as > 1,000,000 disintegrations per minute (dpm) were reported. Of these contaminated surveys, all were in Underground Radioactive Material (URM) areas. The contamination found within eleven of the URH areas was immediately cleaned up and no further action was required. In the remaining three sites the areas were posted and will require decontamination. Radiological Problem Reports (RPR`s) were issued and the sites were turned over to the landlord for further action if required.

  10. 76 FR 68366 - Airworthiness Directives; The Boeing Company Model 777-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will...-induced currents and subsequent damage to composite structures, hydraulic tubes, and actuator control... and could subsequently damage composite structures, hydraulic tubes, and actuator control...

  11. 75 FR 46861 - Airworthiness Directives; Airbus Model A330-200 and -300 Series Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-04

    ... 29, 2010 (75 FR 4710). That earlier NPRM proposed to supersede AD 2007-05-08, Amendment 39-14969 (72 FR 96580, March 5, 2007), to require actions intended to address the unsafe condition for the..., -500, and -600 series airplanes. We have issued AD 2010-01-07, Amendment 39-16165 (75 FR 1538,...

  12. Preliminary Evaluation of PS300: A New Self-Lubricating High Temperature Composite Coating for Use to 800 C

    NASA Technical Reports Server (NTRS)

    Dellacorte, C.; Edmonds, B. J.

    1995-01-01

    This paper introduces PS300, a plasma sprayed, self-lubricating composite coating for use in sliding contacts at temperatures to 800 C. PS300 is a metal bonded chrome oxide coating with silver and BaF2/CaF2 eutectic solid lubricant additives. PS300 is similar to PS200, a chromium carbide based coating, which is currently being investigated for a variety of tribological applications. In pin-on-disk testing up to 650 C, PS300 exhibited comparable friction and wear properties to PS200. The PS300 matrix, which is predominantly chromium oxide rather than chromium carbide, does not require diamond grinding and polishes readily with silicon carbide abrasives greatly reducing manufacturing costs compared to PS200. It is anticipated that PS300 has potential for sliding bearing and seal applications in both aerospace and general industry.

  13. Catch tank inhibitor addition 200-East and 200-West Areas

    SciTech Connect

    Palit, A.N.

    1996-06-21

    Reported is the study of 11 catch tanks in the 200-East Area and the 7 catch tanks in the 200-West Area listed as active. The location, capacity, material of construction, annual total accumulation, annual rain intrusion, waste transfer rate, and access for chemical injection in these tanks are documented. The present and future utilization and isolation plans for the catch tanks are established.

  14. 17 CFR 200.312 - Specific exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...), (H), and (I), and (f) and 17 CFR 200.303, 200.304, and 200.306, insofar as they contain investigatory...)(H), and (e)(4)(I), and (f), and 17 CFR 200.303, 200.304, and 200.306 insofar as they contain... Security in the Workplace Incident Records; and (9) Investor Response Information System (IRIS)....

  15. 17 CFR 200.312 - Specific exemptions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...), (H), and (I), and (f) and 17 CFR 200.303, 200.304, and 200.306, insofar as they contain investigatory...)(H), and (e)(4)(I), and (f), and 17 CFR 200.303, 200.304, and 200.306 insofar as they contain... Security in the Workplace Incident Records; and (9) Investor Response Information System (IRIS)....

  16. 17 CFR 200.312 - Specific exemptions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...), (H), and (I), and (f) and 17 CFR 200.303, 200.304, and 200.306, insofar as they contain investigatory...)(H), and (e)(4)(I), and (f), and 17 CFR 200.303, 200.304, and 200.306 insofar as they contain... Security in the Workplace Incident Records; and (9) Investor Response Information System (IRIS)....

  17. 34 CFR 300.519 - Surrogate parents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Surrogate parents. 300.519 Section 300.519 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.519 Surrogate parents... parent (as defined in § 300.30) can be identified; (2) The public agency, after reasonable...

  18. 11 CFR 300.2 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... connection with a Federal election as that term is used in 11 CFR 300.11, 300.37, 300.50, and 300.51 includes... a public communication (see 11 CFR 100.26). (c) Directly or indirectly establish, finance, maintain... its allocated share of proceeds jointly raised pursuant to 11 CFR 102.17, and otherwise...

  19. 11 CFR 300.2 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... connection with a Federal election as that term is used in 11 CFR 300.11, 300.37, 300.50, and 300.51 includes... a public communication (see 11 CFR 100.26). (c) Directly or indirectly establish, finance, maintain... its allocated share of proceeds jointly raised pursuant to 11 CFR 102.17, and otherwise...

  20. 11 CFR 300.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... connection with a Federal election as that term is used in 11 CFR 300.11, 300.37, 300.50, and 300.51 includes... a public communication (see 11 CFR 100.26). (c) Directly or indirectly establish, finance, maintain... its allocated share of proceeds jointly raised pursuant to 11 CFR 102.17, and otherwise...

  1. 11 CFR 300.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... connection with a Federal election as that term is used in 11 CFR 300.11, 300.37, 300.50, and 300.51 includes... a public communication (see 11 CFR 100.26). (c) Directly or indirectly establish, finance, maintain... its allocated share of proceeds jointly raised pursuant to 11 CFR 102.17, and otherwise...

  2. 11 CFR 300.2 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... connection with a Federal election as that term is used in 11 CFR 300.11, 300.37, 300.50, and 300.51 includes... a public communication (see 11 CFR 100.26). (c) Directly or indirectly establish, finance, maintain... its allocated share of proceeds jointly raised pursuant to 11 CFR 102.17, and otherwise...

  3. 50 CFR 300.66 - Prohibitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... implemented under 50 CFR 300.65(e). (d) Fish for halibut or anchor a vessel with halibut on board within the Sitka Pinnacles Marine Reserve defined at 50 CFR 300.65(f). (e) Fish for subsistence halibut in and off... 300.65(h)(1) and retain more halibut than specified at 50 CFR 300.65(h)(2). (g) Fish for...

  4. 50 CFR 300.66 - Prohibitions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... implemented under 50 CFR 300.65(e). (d) Fish for halibut or anchor a vessel with halibut on board within the Sitka Pinnacles Marine Reserve defined at 50 CFR 300.65(f). (e) Fish for subsistence halibut in and off... 300.65(h)(1) and retain more halibut than specified at 50 CFR 300.65(h)(2). (g) Fish for...

  5. 34 CFR 300.117 - Nonacademic settings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Nonacademic settings. 300.117 Section 300.117 Education... DISABILITIES State Eligibility Least Restrictive Environment (lre) § 300.117 Nonacademic settings. In providing... meals, recess periods, and the services and activities set forth in § 300.107, each public agency...

  6. 34 CFR 300.512 - Hearing rights.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Hearing rights. 300.512 Section 300.512 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.512 Hearing rights. (a....534, or an appeal conducted pursuant to § 300.514, has the right to— (1) Be accompanied and advised...

  7. 34 CFR 300.613 - Access rights.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Access rights. 300.613 Section 300.613 Education... § 300.613 Access rights. (a) Each participating agency must permit parents to inspect and review any... pursuant to § 300.510, and in no case more than 45 days after the request has been made. (b) The right...

  8. 50 CFR 300.301 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Definitions. 300.301 Section 300.301 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Vessels on IUU Vessel Lists § 300.301 Definitions. In addition to the terms defined in § 300.2, the...

  9. 34 CFR 300.516 - Civil action.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Civil action. 300.516 Section 300.516 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.516 Civil action. (a... aggrieved by the findings and decision under § 300.514(b), has the right to bring a civil action...

  10. 34 CFR 300.327 - Educational placements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Educational placements. 300.327 Section 300.327... CHILDREN WITH DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and Educational Placements Development of Iep § 300.327 Educational placements. Consistent with § 300.501(c),...

  11. 34 CFR 300.327 - Educational placements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Educational placements. 300.327 Section 300.327... CHILDREN WITH DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and Educational Placements Development of Iep § 300.327 Educational placements. Consistent with § 300.501(c),...

  12. The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy

    PubMed Central

    Humphries, Brock; Yang, Chengfeng

    2015-01-01

    MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate protein-coding gene expression post-transcriptionally via base pairing between the 5′ seed region of a miRNA and the 3′ untranslated region (3′UTR) of a messenger RNA (mRNA). Recent evidence has supported the critical role that miRNAs play in many diseases including cancer. The miR-200 family consisting of 5 members (miR-200a, -200b, -200c, -141, -429) is an emerging miRNA family that has been shown to play crucial roles in cancer initiation and metastasis, and potentially be important for the diagnosis and treatment of cancer. While miR-200s were found to be critically involved in the metastatic colonization to the lungs in mouse mammary xenograft tumor models, a large number of studies demonstrated their strong suppressive effects on cell transformation, cancer cell proliferation, migration, invasion, tumor growth and metastasis. This review aims to discuss research findings about the role of the miR-200 family in cancer initiation, each step of cancer metastatic cascade, cancer diagnosis and treatment. A comprehensive summary of currently validated miR-200 targets is also presented. It is concluded that miR-200 family may serve as novel targets for the therapy of multiple types of cancer. PMID:25762624

  13. P 300 EVENT RELATED POTENTIAL IN DEPRESSION

    PubMed Central

    Singh, R.; Shukla, R.; Dalal, P.K.; Sinha, P.K.; Trivedi, J.K.

    2000-01-01

    P300 component of the event related potential (ERP) provides one neurophysiological index of cognitive dysfunction in depression. Forty subjects fulfilling DSM-III criteria for depression were compared to 40 age and sex matched normal controls. The P300 was recorded using the auditory odd-ball paradigm. Depressives had a significantly prolonged P300 latency and reduced P300 amplitude as compared to the controls. The P300 latency showed a significant positive correlation with age of the patient and severity of depression while P300 amplitude showed a significant negative correlation with age. The clinical subcategory of depression, duration of illness and sex did not show any relationship with P300 abnormality. Twelve out of 40 depressives (30%) had an abnormal P300. The mean Hamilton Rating Scale for Depression (HRSD) score was significantly high in those with an abnormal P300. PMID:21407978

  14. 300 Area signal cable study

    SciTech Connect

    Whattam, J.W.

    1994-09-15

    This report was prepared to discuss the alternatives available for removing the 300 Area overhead signal cable system. This system, installed in 1969, has been used for various monitoring and communication signaling needs throughout the 300 Area. Over the years this cabling system has deteriorated, has been continually reconfigured, and has been poorly documented to the point of nonreliability. The first step was to look at the systems utilizing the overhead signal cable that are still required for operation. Of the ten systems that once operated via the signal cable, only five are still required; the civil defense evacuation alarms, the public address (PA) system, the criticality alarms, the Pacific Northwest Laboratory Facilities Management Control System (FMCS), and the 384 annunciator panel. Of these five, the criticality alarms and the FMCS have been dealt with under other proposals. Therefore, this study focused on the alternatives available for the remaining three systems (evacuation alarms, PA system, and 384 panel) plus the accountability aid phones. Once the systems to be discussed were determined, then three alternatives for providing the signaling pathway were examined for each system: (1) re-wire using underground communication ducts, (2) use the Integrated Voice/Data Telecommunications System (IVDTS) already installed and operated by US West, and (3) use radio control. Each alternative was developed with an estimated cost, advantages, and disadvantages. Finally, a recommendation was provided for the best alternative for each system.

  15. OM300 Direction Drilling Module

    DOE Data Explorer

    MacGugan, Doug

    2013-08-22

    OM300 – Geothermal Direction Drilling Navigation Tool: Design and produce a prototype directional drilling navigation tool capable of high temperature operation in geothermal drilling Accuracies of 0.1° Inclination and Tool Face, 0.5° Azimuth Environmental Ruggedness typical of existing oil/gas drilling Multiple Selectable Sensor Ranges High accuracy for navigation, low bandwidth High G-range & bandwidth for Stick-Slip and Chirp detection Selectable serial data communications Reduce cost of drilling in high temperature Geothermal reservoirs Innovative aspects of project Honeywell MEMS* Vibrating Beam Accelerometers (VBA) APS Flux-gate Magnetometers Honeywell Silicon-On-Insulator (SOI) High-temperature electronics Rugged High-temperature capable package and assembly process

  16. 11 CFR 300.30 - Accounts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ..., 11 CFR 102.5(a)(4), 11 CFR 106.7(d)(1)(i), 11 CFR 300.33 and 11 CFR 300.34. (2) Levin account. The funds deposited into this account must comply with 11 CFR 300.31. Such funds may be used for the categories of activities described at 11 CFR 300.32(b). (3) Federal account. Federal accounts may be used...

  17. 11 CFR 300.30 - Accounts.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., 11 CFR 102.5(a)(4), 11 CFR 106.7(d)(1)(i), 11 CFR 300.33 and 11 CFR 300.34. (2) Levin account. The funds deposited into this account must comply with 11 CFR 300.31. Such funds may be used for the categories of activities described at 11 CFR 300.32(b). (3) Federal account. Federal accounts may be used...

  18. 11 CFR 300.30 - Accounts.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ..., 11 CFR 102.5(a)(4), 11 CFR 106.7(d)(1)(i), 11 CFR 300.33 and 11 CFR 300.34. (2) Levin account. The funds deposited into this account must comply with 11 CFR 300.31. Such funds may be used for the categories of activities described at 11 CFR 300.32(b). (3) Federal account. Federal accounts may be used...

  19. 11 CFR 300.30 - Accounts.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ..., 11 CFR 102.5(a)(4), 11 CFR 106.7(d)(1)(i), 11 CFR 300.33 and 11 CFR 300.34. (2) Levin account. The funds deposited into this account must comply with 11 CFR 300.31. Such funds may be used for the categories of activities described at 11 CFR 300.32(b). (3) Federal account. Federal accounts may be used...

  20. Viscosity of multi-component molten nitrate salts : liquidus to 200 degrees C.

    SciTech Connect

    Bradshaw, Robert W.

    2010-03-01

    The viscosity of molten salts comprising ternary and quaternary mixtures of the nitrates of sodium, potassium, lithium and calcium was determined experimentally. Viscosity was measured over the temperature range from near the relatively low liquidus temperatures of he individual mixtures to 200C. Molten salt mixtures that do not contain calcium nitrate exhibited relatively low viscosity and an Arrhenius temperature dependence. Molten salt mixtures that contained calcium nitrate were relatively more viscous and viscosity increased as the roportion of calcium nitrate increased. The temperature dependence of viscosity of molten salts containing calcium nitrate displayed curvature, rather than linearity, when plotted in Arrhenius format. Viscosity data for these mixtures were correlated by the Vogel-Fulcher- ammann-Hesse equation.

  1. 34 CFR 300.505 - Electronic mail.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Electronic mail. 300.505 Section 300.505 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.505 Electronic mail. A....508 by an electronic mail communication, if the public agency makes that option available....

  2. 12 CFR 509.300 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... ADJUDICATORY PROCEEDINGS Exemptions under Section 19(e) of the FDIA § 509.300 Scope. The procedures in this subpart D govern hearings on denials of applications for case-by-case exemptions under 12 CFR part 585... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Scope. 509.300 Section 509.300 Banks...

  3. 12 CFR 509.300 - Scope.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... PROCEEDINGS Exemptions under Section 19(e) of the FDIA § 509.300 Scope. The procedures in this subpart D govern hearings on denials of applications for case-by-case exemptions under 12 CFR part 585. Part 585... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Scope. 509.300 Section 509.300 Banks and...

  4. 12 CFR 509.300 - Scope.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... ADJUDICATORY PROCEEDINGS Exemptions under Section 19(e) of the FDIA § 509.300 Scope. The procedures in this subpart D govern hearings on denials of applications for case-by-case exemptions under 12 CFR part 585... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Scope. 509.300 Section 509.300 Banks...

  5. 12 CFR 509.300 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... PROCEEDINGS Exemptions under Section 19(e) of the FDIA § 509.300 Scope. The procedures in this subpart D govern hearings on denials of applications for case-by-case exemptions under 12 CFR part 585. Part 585... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Scope. 509.300 Section 509.300 Banks and...

  6. 12 CFR 509.300 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... ADJUDICATORY PROCEEDINGS Exemptions under Section 19(e) of the FDIA § 509.300 Scope. The procedures in this subpart D govern hearings on denials of applications for case-by-case exemptions under 12 CFR part 585... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Scope. 509.300 Section 509.300 Banks...

  7. 34 CFR 300.4 - Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Definitions Used in This Part § 300.4 Act. Act means the Individuals with Disabilities Education Act, as... 34 Education 2 2010-07-01 2010-07-01 false Act. 300.4 Section 300.4 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE...

  8. 50 CFR 300.43 - Observers.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Observers. 300.43 Section 300.43 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.43 Observers. (a) The operator and each member of the crew of a vessel...

  9. 50 CFR 300.46 - Transshipping requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Transshipping requirements. 300.46 Section 300.46 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.46 Transshipping requirements. (a) Applicability. This...

  10. 50 CFR 300.173 - Vessel identification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Vessel identification. 300.173 Section 300.173 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Pacific Albacore Tuna Fisheries § 300.173 Vessel identification. A U.S. vessel fishing under...

  11. 50 CFR 300.176 - Prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Prohibitions. 300.176 Section 300.176 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Pacific Albacore Tuna Fisheries § 300.176 Prohibitions. It is prohibited for the owner or operator of a...

  12. 50 CFR 300.37 - Radio monitoring.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Radio monitoring. 300.37 Section 300.37 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.37 Radio monitoring. The international distress frequency, 2.182...

  13. 50 CFR 300.44 - Other inspections.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Other inspections. 300.44 Section 300.44 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.44 Other inspections. The operator and each member of the crew of...

  14. 50 CFR 300.41 - Investigation notification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Investigation notification. 300.41 Section 300.41 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.41 Investigation notification. Upon commencement of...

  15. 16 CFR 300.1 - Terms defined.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Terms defined. 300.1 Section 300.1... REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Definitions § 300.1 Terms defined. (a) The term Act... terms rule, rules, regulations and rules and regulations mean the rules and regulations prescribed...

  16. 34 CFR 300.509 - Model forms.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Model forms. 300.509 Section 300.509 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.509 Model forms. (a) Each SEA must develop model forms to assist parents and public agencies in filing a due...

  17. 34 CFR 300.509 - Model forms.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Model forms. 300.509 Section 300.509 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.509 Model forms. (a) Each SEA must develop model forms to assist parents and public agencies in filing a due...

  18. 34 CFR 300.509 - Model forms.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Model forms. 300.509 Section 300.509 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.509 Model forms. (a) Each SEA must develop model forms to assist parents and public agencies in filing a due...

  19. 34 CFR 300.509 - Model forms.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Model forms. 300.509 Section 300.509 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.509 Model forms. (a) Each SEA must develop model forms to assist parents and public agencies in filing a due...

  20. 46 CFR 116.300 - Structural design.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Structural design. 116.300 Section 116.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS CONSTRUCTION AND ARRANGEMENT Hull Structure § 116.300 Structural...

  1. 44 CFR 300.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 300.1 Section 300.1 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY PREPAREDNESS DISASTER PREPAREDNESS ASSISTANCE § 300.1 Definitions. As used in this part: (a)...

  2. 34 CFR 300.135 - Written affirmation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Written affirmation. 300.135 Section 300.135 Education....135 Written affirmation. (a) When timely and meaningful consultation, as required by § 300.134, has occurred, the LEA must obtain a written affirmation signed by the representatives of participating...

  3. 34 CFR 300.135 - Written affirmation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Written affirmation. 300.135 Section 300.135 Education....135 Written affirmation. (a) When timely and meaningful consultation, as required by § 300.134, has occurred, the LEA must obtain a written affirmation signed by the representatives of participating...

  4. 34 CFR 300.135 - Written affirmation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Written affirmation. 300.135 Section 300.135 Education....135 Written affirmation. (a) When timely and meaningful consultation, as required by § 300.134, has occurred, the LEA must obtain a written affirmation signed by the representatives of participating...

  5. 34 CFR 300.135 - Written affirmation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Written affirmation. 300.135 Section 300.135 Education....135 Written affirmation. (a) When timely and meaningful consultation, as required by § 300.134, has occurred, the LEA must obtain a written affirmation signed by the representatives of participating...

  6. 16 CFR 300.16 - Ornamentation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 1 2014-01-01 2014-01-01 false Ornamentation. 300.16 Section 300.16 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.16 Ornamentation. (a) Where the...

  7. 16 CFR 300.16 - Ornamentation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false Ornamentation. 300.16 Section 300.16 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.16 Ornamentation. (a) Where the...

  8. 16 CFR 300.16 - Ornamentation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false Ornamentation. 300.16 Section 300.16 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.16 Ornamentation. (a) Where the...

  9. 16 CFR 300.16 - Ornamentation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 1 2013-01-01 2013-01-01 false Ornamentation. 300.16 Section 300.16 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.16 Ornamentation. (a) Where the wool product contains fiber ornamentation...

  10. 16 CFR 300.16 - Ornamentation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Ornamentation. 300.16 Section 300.16 Commercial Practices FEDERAL TRADE COMMISSION REGULATIONS UNDER SPECIFIC ACTS OF CONGRESS RULES AND REGULATIONS UNDER THE WOOL PRODUCTS LABELING ACT OF 1939 Labeling § 300.16 Ornamentation. (a) Where the...

  11. 14 CFR 1206.300 - Exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Exemptions. 1206.300 Section 1206.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION AVAILABILITY OF AGENCY RECORDS TO MEMBERS OF THE PUBLIC Exemptions § 1206.300 Exemptions. (a) Under 5 U.S.C. 552(b) Agency records...

  12. 14 CFR 1203.300 - General.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false General. 1203.300 Section 1203.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.300 General. In general, the types of...

  13. 14 CFR 1203.300 - General.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true General. 1203.300 Section 1203.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.300 General. In general, the types of...

  14. 14 CFR 1203.300 - General.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false General. 1203.300 Section 1203.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.300 General. In general, the types of...

  15. 5 CFR 300.606 - Agency authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Agency authority. 300.606 Section 300.606 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.606 Agency authority. An agency may expand on these restrictions...

  16. 5 CFR 300.601 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Purpose. 300.601 Section 300.601 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.601 Purpose. The restrictions in this subpart are intended to...

  17. 5 CFR 300.603 - Coverage.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Coverage. 300.603 Section 300.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.603 Coverage. (a) Coverage. This subpart applies to advancement to a...

  18. 5 CFR 300.602 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Definitions. 300.602 Section 300.602 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.602 Definitions. In this subpart— Advancement means a promotion (including...

  19. 5 CFR 300.601 - Purpose.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Purpose. 300.601 Section 300.601 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.601 Purpose. The restrictions in this subpart are intended to...

  20. 5 CFR 300.603 - Coverage.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Coverage. 300.603 Section 300.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.603 Coverage. (a) Coverage. This subpart applies to advancement to a...

  1. 5 CFR 300.606 - Agency authority.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Agency authority. 300.606 Section 300.606 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.606 Agency authority. An agency may expand on these restrictions...

  2. 34 CFR 300.29 - Native language.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Native language. 300.29 Section 300.29 Education... DISABILITIES General Definitions Used in This Part § 300.29 Native language. (a) Native language, when used with respect to an individual who is limited English proficient, means the following: (1) The...

  3. 33 CFR 101.300 - Preparedness communications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Preparedness communications. 101.300 Section 101.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: GENERAL Communication (Port-Facility-Vessel) § 101.300 Preparedness communications. (a) Notification of MARSEC...

  4. 34 CFR 300.321 - IEP Team.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false IEP Team. 300.321 Section 300.321 Education Regulations... Placements Individualized Education Programs § 300.321 IEP Team. (a) General. The public agency must ensure that the IEP Team for each child with a disability includes— (1) The parents of the child; (2) Not...

  5. 5 CFR 300.402 - Coverage.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Coverage. 300.402 Section 300.402 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Use of Commercial Recruiting Firms and Nonprofit Employment Services § 300.402 Coverage. This part applies...

  6. 5 CFR 300.502 - Coverage.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Coverage. 300.502 Section 300.502 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Use of Private Sector Temporaries § 300.502 Coverage. (a) These regulations apply to the competitive service...

  7. 5 CFR 300.502 - Coverage.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Coverage. 300.502 Section 300.502 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Use of Private Sector Temporaries § 300.502 Coverage. (a) These regulations apply to the competitive service...

  8. 5 CFR 300.502 - Coverage.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Coverage. 300.502 Section 300.502 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Use of Private Sector Temporaries § 300.502 Coverage. (a) These regulations apply to the competitive service...

  9. 5 CFR 300.502 - Coverage.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Coverage. 300.502 Section 300.502 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Use of Private Sector Temporaries § 300.502 Coverage. (a) These regulations apply to the competitive service...

  10. 5 CFR 300.702 - Coverage.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Coverage. 300.702 Section 300.702 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Statutory Bar to Appointment of Persons Who Fail To Register Under Selective Service Law § 300.702...

  11. 5 CFR 300.502 - Coverage.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Coverage. 300.502 Section 300.502 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Use of Private Sector Temporaries § 300.502 Coverage. (a) These regulations apply to the competitive service...

  12. 5 CFR 300.402 - Coverage.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Coverage. 300.402 Section 300.402 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Use of Commercial Recruiting Firms and Nonprofit Employment Services § 300.402 Coverage. This part applies...

  13. 5 CFR 300.702 - Coverage.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Coverage. 300.702 Section 300.702 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Statutory Bar to Appointment of Persons Who Fail To Register Under Selective Service Law § 300.702...

  14. 5 CFR 300.702 - Coverage.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Coverage. 300.702 Section 300.702 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Statutory Bar to Appointment of Persons Who Fail To Register Under Selective Service Law § 300.702...

  15. 5 CFR 300.402 - Coverage.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Coverage. 300.402 Section 300.402 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Use of Commercial Recruiting Firms and Nonprofit Employment Services § 300.402 Coverage. This part applies...

  16. 5 CFR 300.402 - Coverage.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Coverage. 300.402 Section 300.402 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Use of Commercial Recruiting Firms and Nonprofit Employment Services § 300.402 Coverage. This part applies...

  17. 33 CFR 143.300 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Applicability. 143.300 Section 143.300 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES DESIGN AND EQUIPMENT Vessels § 143.300 Applicability. This subpart applies to...

  18. 50 CFR 300.213 - Vessel information.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Vessel information. 300.213 Section 300... REGULATIONS Western and Central Pacific Fisheries for Highly Migratory Species § 300.213 Vessel information... information about the vessel and its ownership and operation, and the authorized fishing activities,...

  19. 50 CFR 300.44 - Other inspections.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Other inspections. 300.44 Section 300.44 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.44 Other inspections. The operator and each member of the crew of...

  20. 50 CFR 300.39 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.39 Exceptions. (a) The prohibitions of § 300.38 and the licensing requirements of § 300.32 do not apply to fishing for albacore tuna by vessels using the trolling method or...

  1. 50 CFR 300.173 - Vessel identification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Vessel identification. 300.173 Section 300.173 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Pacific Albacore Tuna Fisheries § 300.173 Vessel identification. A U.S. vessel fishing under...

  2. 50 CFR 300.37 - Radio monitoring.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Radio monitoring. 300.37 Section 300.37 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.37 Radio monitoring. The international distress frequency, 2.182...

  3. 50 CFR 300.40 - Civil penalties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Civil penalties. 300.40 Section 300.40 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.40 Civil penalties. The procedures of 15 CFR part 904 apply to...

  4. 50 CFR 300.41 - Investigation notification.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Investigation notification. 300.41 Section 300.41 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.41 Investigation notification. Upon commencement of...

  5. 50 CFR 300.46 - Transshipping requirements.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Transshipping requirements. 300.46 Section 300.46 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.46 Transshipping requirements. (a) Applicability. This...

  6. 21 CFR 73.300 - Carrot oil.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Carrot oil. 73.300 Section 73.300 Food and Drugs... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.300 Carrot oil. (a) Identity. (1) The color additive carrot... extraction of edible carrots (Daucus carota L.) with subsequent removal of the hexane by vacuum...

  7. 21 CFR 73.300 - Carrot oil.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Carrot oil. 73.300 Section 73.300 Food and Drugs... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.300 Carrot oil. (a) Identity. (1) The color additive carrot... extraction of edible carrots (Daucus carota L.) with subsequent removal of the hexane by vacuum...

  8. 21 CFR 73.300 - Carrot oil.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Carrot oil. 73.300 Section 73.300 Food and Drugs... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.300 Carrot oil. (a) Identity. (1) The color additive carrot... extraction of edible carrots (Daucus carota L.) with subsequent removal of the hexane by vacuum...

  9. 21 CFR 73.300 - Carrot oil.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Carrot oil. 73.300 Section 73.300 Food and Drugs... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.300 Carrot oil. (a) Identity. (1) The color additive carrot... extraction of edible carrots (Daucus carota L.) with subsequent removal of the hexane by vacuum...

  10. 21 CFR 73.300 - Carrot oil.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Carrot oil. 73.300 Section 73.300 Food and Drugs... ADDITIVES EXEMPT FROM CERTIFICATION Foods § 73.300 Carrot oil. (a) Identity. (1) The color additive carrot... extraction of edible carrots (Daucus carota L.) with subsequent removal of the hexane by vacuum...

  11. 34 CFR 300.105 - Assistive technology.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Assistive technology. 300.105 Section 300.105 Education... DISABILITIES State Eligibility Other Fape Requirements § 300.105 Assistive technology. (a) Each public agency must ensure that assistive technology devices or assistive technology services, or both, as those...

  12. 34 CFR 300.105 - Assistive technology.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Assistive technology. 300.105 Section 300.105 Education... DISABILITIES State Eligibility Other Fape Requirements § 300.105 Assistive technology. (a) Each public agency must ensure that assistive technology devices or assistive technology services, or both, as those...

  13. 34 CFR 300.105 - Assistive technology.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Assistive technology. 300.105 Section 300.105 Education... DISABILITIES State Eligibility Other Fape Requirements § 300.105 Assistive technology. (a) Each public agency must ensure that assistive technology devices or assistive technology services, or both, as those...

  14. 34 CFR 300.105 - Assistive technology.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Assistive technology. 300.105 Section 300.105 Education... DISABILITIES State Eligibility Other Fape Requirements § 300.105 Assistive technology. (a) Each public agency must ensure that assistive technology devices or assistive technology services, or both, as those...

  15. 34 CFR 300.105 - Assistive technology.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Assistive technology. 300.105 Section 300.105 Education... DISABILITIES State Eligibility Other Fape Requirements § 300.105 Assistive technology. (a) Each public agency must ensure that assistive technology devices or assistive technology services, or both, as those...

  16. 34 CFR 300.510 - Resolution process.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Resolution process. 300.510 Section 300.510 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.510 Resolution process. (a) Resolution meeting. (1) Within 15 days of receiving notice of the parent's due process...

  17. 34 CFR 300.322 - Parent participation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Parent participation. 300.322 Section 300.322 Education... Placements Individualized Education Programs § 300.322 Parent participation. (a) Public agency responsibility—general. Each public agency must take steps to ensure that one or both of the parents of a child with...

  18. 34 CFR 300.30 - Parent.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Parent. 300.30 Section 300.30 Education Regulations of... General Definitions Used in This Part § 300.30 Parent. (a) Parent means— (1) A biological or adoptive parent of a child; (2) A foster parent, unless State law, regulations, or contractual obligations with...

  19. 50 CFR 300.104 - Scientific research.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Scientific research. 300.104 Section 300... REGULATIONS Antarctic Marine Living Resources § 300.104 Scientific research. (a) The management measures... to be used. (vi) Survey design and methods of data analyses. (vii) Data to be collected. (3)...

  20. 50 CFR 300.104 - Scientific research.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Scientific research. 300.104 Section 300... REGULATIONS Antarctic Marine Living Resources § 300.104 Scientific research. (a) The management measures... to be used. (vi) Survey design and methods of data analyses. (vii) Data to be collected. (3)...

  1. 5 CFR 300.606 - Agency authority.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Agency authority. 300.606 Section 300.606 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.606 Agency authority. An agency may expand on these restrictions...

  2. 5 CFR 300.606 - Agency authority.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Agency authority. 300.606 Section 300.606 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.606 Agency authority. An agency may expand on these restrictions...

  3. 5 CFR 300.602 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Definitions. 300.602 Section 300.602 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.602 Definitions. In this subpart— Advancement means a promotion (including...

  4. 5 CFR 300.603 - Coverage.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Coverage. 300.603 Section 300.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.603 Coverage. (a) Coverage. This subpart applies to advancement to a...

  5. 5 CFR 300.606 - Agency authority.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Agency authority. 300.606 Section 300.606 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.606 Agency authority. An agency may expand on these restrictions...

  6. 5 CFR 300.602 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Definitions. 300.602 Section 300.602 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.602 Definitions. In this subpart— Advancement means a promotion (including...

  7. 5 CFR 300.601 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Purpose. 300.601 Section 300.601 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.601 Purpose. The restrictions in this subpart are intended to...

  8. 5 CFR 300.603 - Coverage.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Coverage. 300.603 Section 300.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.603 Coverage. (a) Coverage. This subpart applies to advancement to a...

  9. 5 CFR 300.601 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Purpose. 300.601 Section 300.601 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.601 Purpose. The restrictions in this subpart are intended to...

  10. 5 CFR 300.603 - Coverage.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Coverage. 300.603 Section 300.603 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.603 Coverage. (a) Coverage. This subpart applies to advancement to a...

  11. 5 CFR 300.601 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Purpose. 300.601 Section 300.601 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.601 Purpose. The restrictions in this subpart are intended to...

  12. 5 CFR 300.602 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Definitions. 300.602 Section 300.602 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT (GENERAL) Time-In-Grade Restrictions § 300.602 Definitions. In this subpart— Advancement means a promotion (including...

  13. 40 CFR 82.300 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 18 2012-07-01 2012-07-01 false Purpose. 82.300 Section 82.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Ban on Refrigeration and Air-Conditioning Appliances Containing HCFCs § 82.300 Purpose....

  14. 40 CFR 82.300 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 17 2011-07-01 2011-07-01 false Purpose. 82.300 Section 82.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Ban on Refrigeration and Air-Conditioning Appliances Containing HCFCs § 82.300 Purpose....

  15. 40 CFR 82.300 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 18 2013-07-01 2013-07-01 false Purpose. 82.300 Section 82.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Ban on Refrigeration and Air-Conditioning Appliances Containing HCFCs § 82.300 Purpose....

  16. 40 CFR 82.300 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 18 2014-07-01 2014-07-01 false Purpose. 82.300 Section 82.300 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) PROTECTION OF STRATOSPHERIC OZONE Ban on Refrigeration and Air-Conditioning Appliances Containing HCFCs § 82.300 Purpose....

  17. 21 CFR 137.300 - Farina.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Farina. 137.300 Section 137.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Related Products § 137.300 Farina. (a) Farina is the food prepared by grinding and bolting cleaned...

  18. 21 CFR 137.300 - Farina.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Farina. 137.300 Section 137.300 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... Related Products § 137.300 Farina. (a) Farina is the food prepared by grinding and bolting cleaned...

  19. Deep stall characteristics of MU-300

    NASA Technical Reports Server (NTRS)

    Hanai, T.

    1986-01-01

    The deep stall characteristics of the MU-300 Diamond aircraft are described. The MU-300 obtained type certification from the FAA in 1981, and from Canada, West Germany, and England in 1983. The aircraft has achieved a high angle of attack. The aerodynamic design, structural dimensions, and flight tests of the MU-300 are described.

  20. 5 CFR 300.103 - Basic requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Basic requirements. 300.103 Section 300... (GENERAL) Employment Practices § 300.103 Basic requirements. (a) Job analysis. Each employment practice of... identify: (1) The basic duties and responsibilities; (2) The knowledges, skills, and abilities required...

  1. 5 CFR 300.103 - Basic requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Basic requirements. 300.103 Section 300... (GENERAL) Employment Practices § 300.103 Basic requirements. (a) Job analysis. Each employment practice of... identify: (1) The basic duties and responsibilities; (2) The knowledges, skills, and abilities required...

  2. 5 CFR 300.103 - Basic requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Basic requirements. 300.103 Section 300... (GENERAL) Employment Practices § 300.103 Basic requirements. (a) Job analysis. Each employment practice of... identify: (1) The basic duties and responsibilities; (2) The knowledges, skills, and abilities required...

  3. 34 CFR 300.517 - Attorneys' fees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Attorneys' fees. 300.517 Section 300.517 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.517 Attorneys' fees... its discretion, may award reasonable attorneys' fees as part of the costs to— (i) The prevailing...

  4. 10 CFR 435.300 - Purpose.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 3 2012-01-01 2012-01-01 false Purpose. 435.300 Section 435.300 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR NEW FEDERAL LOW-RISE RESIDENTIAL BUILDINGS Mandatory Energy Efficiency Standards for Federal Residential Buildings § 435.300 Purpose. (a) This...

  5. 10 CFR 435.300 - Purpose.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 3 2013-01-01 2013-01-01 false Purpose. 435.300 Section 435.300 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR NEW FEDERAL LOW-RISE RESIDENTIAL BUILDINGS Mandatory Energy Efficiency Standards for Federal Residential Buildings § 435.300 Purpose. (a) This...

  6. 10 CFR 435.300 - Purpose.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 3 2014-01-01 2014-01-01 false Purpose. 435.300 Section 435.300 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY STANDARDS FOR NEW FEDERAL LOW-RISE RESIDENTIAL BUILDINGS Mandatory Energy Efficiency Standards for Federal Residential Buildings § 435.300 Purpose. (a) This...

  7. 42 CFR 425.300 - Compliance plan.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 3 2012-10-01 2012-10-01 false Compliance plan. 425.300 Section 425.300 Public... Protections § 425.300 Compliance plan. (a) The ACO must have a compliance plan that includes at least the...) An ACO's compliance plan must be in compliance with and be updated periodically to reflect changes...

  8. 42 CFR 425.300 - Compliance plan.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 3 2013-10-01 2013-10-01 false Compliance plan. 425.300 Section 425.300 Public... Protections § 425.300 Compliance plan. (a) The ACO must have a compliance plan that includes at least the...) An ACO's compliance plan must be in compliance with and be updated periodically to reflect changes...

  9. 34 CFR 300.37 - Services plan.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Services plan. 300.37 Section 300.37 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.37 Services plan. Services plan means a...

  10. 24 CFR 300.9 - Office.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Office. 300.9 Section 300.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) GOVERNMENT NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.9 Office. The Association directs its operations from...

  11. 49 CFR 179.300-4 - Insulation.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Insulation. 179.300-4 Section 179.300-4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-4 Insulation. (a) Tanks shall not...

  12. 49 CFR 179.300-4 - Insulation.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Insulation. 179.300-4 Section 179.300-4 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY... Specifications for Multi-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-4 Insulation. (a) Tanks...

  13. 49 CFR 179.300-4 - Insulation.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Insulation. 179.300-4 Section 179.300-4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-4 Insulation. (a) Tanks shall not...

  14. 49 CFR 179.300-4 - Insulation.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Insulation. 179.300-4 Section 179.300-4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-4 Insulation. (a) Tanks shall not...

  15. 49 CFR 179.300-4 - Insulation.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Insulation. 179.300-4 Section 179.300-4 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY...-Unit Tank Car Tanks (Classes DOT-106A and 110AW) § 179.300-4 Insulation. (a) Tanks shall not...

  16. 46 CFR 118.300 - Fire pumps.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 4 2013-10-01 2013-10-01 false Fire pumps. 118.300 Section 118.300 Shipping COAST GUARD... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Fire Main System § 118.300 Fire pumps. (a) A self priming, power driven fire pump must be installed on each vessel. (b) On...

  17. 46 CFR 181.300 - Fire pumps.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Fire pumps. 181.300 Section 181.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Fire Main System § 181.300 Fire pumps. (a) A self priming, power driven fire pump must...

  18. 46 CFR 118.300 - Fire pumps.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Fire pumps. 118.300 Section 118.300 Shipping COAST GUARD... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Fire Main System § 118.300 Fire pumps. (a) A self priming, power driven fire pump must be installed on each vessel. (b) On...

  19. 46 CFR 181.300 - Fire pumps.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Fire pumps. 181.300 Section 181.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Fire Main System § 181.300 Fire pumps. (a) A self priming, power driven fire pump must...

  20. 46 CFR 118.300 - Fire pumps.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Fire pumps. 118.300 Section 118.300 Shipping COAST GUARD... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Fire Main System § 118.300 Fire pumps. (a) A self priming, power driven fire pump must be installed on each vessel. (b) On...

  1. 46 CFR 118.300 - Fire pumps.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Fire pumps. 118.300 Section 118.300 Shipping COAST GUARD... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Fire Main System § 118.300 Fire pumps. (a) A self priming, power driven fire pump must be installed on each vessel. (b) On...

  2. 46 CFR 118.300 - Fire pumps.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Fire pumps. 118.300 Section 118.300 Shipping COAST GUARD... OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS FIRE PROTECTION EQUIPMENT Fire Main System § 118.300 Fire pumps. (a) A self priming, power driven fire pump must be installed on each vessel. (b) On...

  3. 46 CFR 181.300 - Fire pumps.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Fire pumps. 181.300 Section 181.300 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) FIRE PROTECTION EQUIPMENT Fire Main System § 181.300 Fire pumps. (a) A self priming, power driven fire pump must...

  4. 24 CFR 300.15 - Exceptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Exceptions. 300.15 Section 300.15 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) GOVERNMENT NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.15 Exceptions....

  5. 24 CFR 300.9 - Office.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Office. 300.9 Section 300.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) GOVERNMENT NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.9 Office....

  6. 24 CFR 300.3 - Description.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Description. 300.3 Section 300.3 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) GOVERNMENT NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.3 Description....

  7. 34 CFR 300.135 - Written affirmation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Written affirmation. 300.135 Section 300.135 Education....135 Written affirmation. (a) When timely and meaningful consultation, as required by § 300.134, has occurred, the LEA must obtain a written affirmation signed by the representatives of participating...

  8. 34 CFR 300.44 - Universal design.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Universal design. 300.44 Section 300.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.44 Universal design. Universal design has the...

  9. 34 CFR 300.44 - Universal design.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Universal design. 300.44 Section 300.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.44 Universal design. Universal design has the...

  10. 34 CFR 300.44 - Universal design.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Universal design. 300.44 Section 300.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.44 Universal design. Universal design has the...

  11. 29 CFR 99.300 - Auditee responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Auditee responsibilities. 99.300 Section 99.300 Labor Office of the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditees § 99.300 Auditee responsibilities. The auditee shall: (a) Identify, in its accounts, all Federal...

  12. 38 CFR 41.300 - Auditee responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Auditee responsibilities. 41.300 Section 41.300 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS (CONTINUED) AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS Auditees § 41.300...

  13. 34 CFR 300.230 - SEA flexibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false SEA flexibility. 300.230 Section 300.230 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES Local Educational Agency Eligibility § 300.230 SEA flexibility. (a) Adjustment to State...

  14. 34 CFR 300.230 - SEA flexibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false SEA flexibility. 300.230 Section 300.230 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES Local Educational Agency Eligibility § 300.230 SEA flexibility. (a) Adjustment to State...

  15. 34 CFR 300.230 - SEA flexibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true SEA flexibility. 300.230 Section 300.230 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES Local Educational Agency Eligibility § 300.230 SEA flexibility. (a) Adjustment to State...

  16. 50 CFR 300.129 - Fishing year.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Fishing year. 300.129 Section 300.129 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Vessels of the United States Fishing in Colombian Treaty Waters § 300.129 Fishing year. The fishing...

  17. 50 CFR 300.129 - Fishing year.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Fishing year. 300.129 Section 300.129 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Vessels of the United States Fishing in Colombian Treaty Waters § 300.129 Fishing year. The fishing...

  18. 50 CFR 300.129 - Fishing year.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Fishing year. 300.129 Section 300.129 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Vessels of the United States Fishing in Colombian Treaty Waters § 300.129 Fishing year. The fishing...

  19. 50 CFR 300.129 - Fishing year.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Fishing year. 300.129 Section 300.129 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Vessels of the United States Fishing in Colombian Treaty Waters § 300.129 Fishing year. The fishing...

  20. 50 CFR 300.129 - Fishing year.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Fishing year. 300.129 Section 300.129 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Vessels of the United States Fishing in Colombian Treaty Waters § 300.129 Fishing year. The fishing...

  1. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  2. 34 CFR 300.19 - Homeless children.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Homeless children. 300.19 Section 300.19 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.19 Homeless children. Homeless children has...

  3. 34 CFR 300.19 - Homeless children.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Homeless children. 300.19 Section 300.19 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.19 Homeless children. Homeless children has...

  4. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  5. 34 CFR 300.19 - Homeless children.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Homeless children. 300.19 Section 300.19 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.19 Homeless children. Homeless children has...

  6. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  7. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  8. 34 CFR 300.19 - Homeless children.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Homeless children. 300.19 Section 300.19 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.19 Homeless children. Homeless children has...

  9. 34 CFR 300.111 - Child find.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Child find. 300.111 Section 300.111 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES State Eligibility Other Fape Requirements § 300.111 Child find. (a) General. (1) The State...

  10. 34 CFR 300.19 - Homeless children.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Homeless children. 300.19 Section 300.19 Education... REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH DISABILITIES General Definitions Used in This Part § 300.19 Homeless children. Homeless children has...

  11. 32 CFR 300.9 - Appeals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Program Regulation at 32 CFR 286.24. The appeal should be accompanied by copies of the initial request and... 32 National Defense 2 2014-07-01 2014-07-01 false Appeals. 300.9 Section 300.9 National Defense... Appeals. When an IDA makes an adverse determination (see § 300.3(b)) the requester may appeal...

  12. 34 CFR 300.532 - Appeal.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Appeal. 300.532 Section 300.532 Education Regulations of... Procedural Safeguards Due Process Procedures for Parents and Children Discipline Procedures § 300.532 Appeal... injury to the child or others, may appeal the decision by requesting a hearing. The hearing is...

  13. 24 CFR 300.9 - Office.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Office. 300.9 Section 300.9 Housing and Urban Development Regulations Relating to Housing and Urban Development (Continued) GOVERNMENT NATIONAL MORTGAGE ASSOCIATION, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT GENERAL § 300.9 Office....

  14. 50 CFR 300.106 - Exploratory fisheries.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Exploratory fisheries. 300.106 Section 300.106 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Antarctic Marine Living Resources § 300.106 Exploratory fisheries. (a) An exploratory fishery, for purposes of this section, is a...

  15. 50 CFR 300.106 - Exploratory fisheries.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Exploratory fisheries. 300.106 Section 300.106 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Antarctic Marine Living Resources § 300.106 Exploratory fisheries. (a) An exploratory fishery, for purposes of this section, is a...

  16. 50 CFR 300.106 - Exploratory fisheries.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Exploratory fisheries. 300.106 Section 300.106 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Antarctic Marine Living Resources § 300.106 Exploratory fisheries. (a) An exploratory fishery, for purposes of this section, is a...

  17. 6 CFR 27.300 - Orders.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Orders. 27.300 Section 27.300 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders and Adjudications § 27.300 Orders. (a) Orders Generally. When the Assistant Secretary determines...

  18. 6 CFR 27.300 - Orders.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Orders. 27.300 Section 27.300 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders and Adjudications § 27.300 Orders. (a) Orders Generally. When the Assistant Secretary determines...

  19. 6 CFR 27.300 - Orders.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Orders. 27.300 Section 27.300 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders and Adjudications § 27.300 Orders. (a) Orders Generally. When the Assistant Secretary determines...

  20. 6 CFR 27.300 - Orders.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Orders. 27.300 Section 27.300 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CHEMICAL FACILITY ANTI-TERRORISM STANDARDS Orders and Adjudications § 27.300 Orders. (a) Orders Generally. When the Assistant Secretary determines...

  1. 41 CFR 60-300.3 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 1 2013-07-01 2013-07-01 false 60-300.3 Section 60-300.3 Public Contracts and Property Management Other Provisions Relating to Public Contracts OFFICE OF... Matters, Equal Opportunity Clause § 60-300.3...

  2. 41 CFR 60-300.3 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false 60-300.3 Section 60-300.3 Public Contracts and Property Management Other Provisions Relating to Public Contracts OFFICE OF... SERVICE MEDAL VETERANS Preliminary Matters, Equal Opportunity Clause § 60-300.3...

  3. 41 CFR 60-300.80 - Recordkeeping.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 41 Public Contracts and Property Management 1 2014-07-01 2014-07-01 false Recordkeeping. 60-300.80 Section 60-300.80 Public Contracts and Property Management Other Provisions Relating to Public Contracts... FORCES SERVICE MEDAL VETERANS Ancillary Matters § 60-300.80 Recordkeeping. (a) General...

  4. 50 CFR 300.104 - Scientific research.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Scientific research. 300.104 Section 300... REGULATIONS Antarctic Marine Living Resources § 300.104 Scientific research. (a) The management measures... vessel for research purposes, unless otherwise indicated. (b) Catches taken by any vessel for...

  5. 50 CFR 300.106 - Exploratory fisheries.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Exploratory fisheries. 300.106 Section 300.106 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Antarctic Marine Living Resources § 300.106 Exploratory fisheries. (a) An exploratory fishery,...

  6. 50 CFR 300.106 - Exploratory fisheries.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Exploratory fisheries. 300.106 Section 300.106 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Antarctic Marine Living Resources § 300.106 Exploratory fisheries. (a) An exploratory fishery,...

  7. 50 CFR 300.104 - Scientific research.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Scientific research. 300.104 Section 300.104 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Antarctic Marine Living Resources § 300.104 Scientific research. (a) The management...

  8. 50 CFR 300.104 - Scientific research.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Scientific research. 300.104 Section 300.104 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Antarctic Marine Living Resources § 300.104 Scientific research. (a) The management...

  9. 46 CFR 116.300 - Structural design.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Structural design. 116.300 Section 116.300 Shipping... Structure § 116.300 Structural design. Except as otherwise allowed by this subpart, a vessel must comply with the structural design requirements of one of the standards listed below for the hull material...

  10. 34 CFR 300.44 - Universal design.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Universal design. 300.44 Section 300.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.44 Universal design. Universal design has the...

  11. 34 CFR 300.44 - Universal design.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Universal design. 300.44 Section 300.44 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.44 Universal design. Universal design has the...

  12. 46 CFR 116.300 - Structural design.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 4 2011-10-01 2011-10-01 false Structural design. 116.300 Section 116.300 Shipping... Structure § 116.300 Structural design. Except as otherwise allowed by this subpart, a vessel must comply with the structural design requirements of one of the standards listed below for the hull material...

  13. 32 CFR 300.5 - General.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... PROGRAM DEFENSE LOGISTICS AGENCY FREEDOM OF INFORMATION ACT PROGRAM Exemptions § 300.5 General. Refer to the DoD FOIA Program regulations codified at 32 CFR part 286, subpart C, Exemptions. ... 32 National Defense 2 2014-07-01 2014-07-01 false General. 300.5 Section 300.5 National...

  14. 50 CFR 300.41 - Investigation notification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Investigation notification. 300.41 Section 300.41 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.41 Investigation notification. Upon commencement of...

  15. 50 CFR 300.176 - Prohibitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Prohibitions. 300.176 Section 300.176 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Pacific Albacore Tuna Fisheries § 300.176 Prohibitions. It is prohibited for the owner or operator of a...

  16. 50 CFR 300.41 - Investigation notification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Investigation notification. 300.41 Section 300.41 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.41 Investigation notification. Upon commencement of...

  17. 50 CFR 300.43 - Observers.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Observers. 300.43 Section 300.43 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.43 Observers. (a) The operator and each member of the crew of a vessel...

  18. 50 CFR 300.44 - Other inspections.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Other inspections. 300.44 Section 300.44 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.44 Other inspections. The operator and each member of the crew of...

  19. 50 CFR 300.173 - Vessel identification.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Vessel identification. 300.173 Section 300.173 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Pacific Albacore Tuna Fisheries § 300.173 Vessel identification. Each U.S. vessel fishing...

  20. 50 CFR 300.176 - Prohibitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Prohibitions. 300.176 Section 300.176 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Pacific Albacore Tuna Fisheries § 300.176 Prohibitions. It is prohibited for the owner or operator of a...

  1. 50 CFR 300.39 - Exceptions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... South Pacific Tuna Fisheries § 300.39 Exceptions. (a) The prohibitions of § 300.38 and the licensing requirements of § 300.32 do not apply to fishing for albacore tuna by vessels using the trolling method or...

  2. 50 CFR 300.39 - Exceptions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... South Pacific Tuna Fisheries § 300.39 Exceptions. (a) The prohibitions of § 300.38 and the licensing requirements of § 300.32 do not apply to fishing for albacore tuna by vessels using the trolling method or...

  3. 50 CFR 300.173 - Vessel identification.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Vessel identification. 300.173 Section 300.173 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Pacific Albacore Tuna Fisheries § 300.173 Vessel identification. Each U.S. vessel fishing...

  4. 50 CFR 300.40 - Civil penalties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Civil penalties. 300.40 Section 300.40 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.40 Civil penalties. The procedures of 15 CFR part 904 apply to...

  5. 50 CFR 300.173 - Vessel identification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Vessel identification. 300.173 Section 300.173 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Pacific Albacore Tuna Fisheries § 300.173 Vessel identification. Each U.S. vessel fishing...

  6. 50 CFR 300.44 - Other inspections.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Other inspections. 300.44 Section 300.44 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.44 Other inspections. The operator and each member of the crew of...

  7. 50 CFR 300.41 - Investigation notification.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Investigation notification. 300.41 Section 300.41 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.41 Investigation notification. Upon commencement of...

  8. 50 CFR 300.46 - Transshipping requirements.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Transshipping requirements. 300.46 Section 300.46 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.46 Transshipping requirements. (a) Applicability. This...

  9. 50 CFR 300.176 - Prohibitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Prohibitions. 300.176 Section 300.176 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Pacific Albacore Tuna Fisheries § 300.176 Prohibitions. It is prohibited for the owner or operator of a...

  10. 50 CFR 300.40 - Civil penalties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Civil penalties. 300.40 Section 300.40 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.40 Civil penalties. The procedures of 15 CFR part 904 apply to...

  11. 50 CFR 300.40 - Civil penalties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Civil penalties. 300.40 Section 300.40 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.40 Civil penalties. The procedures of 15 CFR part 904 apply to...

  12. 50 CFR 300.46 - Transshipping requirements.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Transshipping requirements. 300.46 Section 300.46 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.46 Transshipping requirements. (a) Applicability. This...

  13. 50 CFR 300.43 - Observers.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Observers. 300.43 Section 300.43 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.43 Observers. (a) The operator and each member of the crew of a vessel...

  14. 50 CFR 300.44 - Other inspections.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Other inspections. 300.44 Section 300.44 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.44 Other inspections. The operator and each member of the crew of...

  15. 50 CFR 300.39 - Exceptions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... South Pacific Tuna Fisheries § 300.39 Exceptions. (a) The prohibitions of § 300.38 and the licensing requirements of § 300.32 do not apply to fishing for albacore tuna by vessels using the trolling method or...

  16. 50 CFR 300.46 - Transshipping requirements.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Transshipping requirements. 300.46 Section 300.46 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.46 Transshipping requirements. (a) Applicability. This...

  17. 12 CFR 390.300 - Note account.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Note account. 390.300 Section 390.300 Banks and... Associations § 390.300 Note account. The term note account means a note, subject to the right of immediate call... Department regulations. Note accounts are not savings accounts or savings deposits....

  18. 12 CFR 390.300 - Note account.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Note account. 390.300 Section 390.300 Banks and... Associations § 390.300 Note account. The term note account means a note, subject to the right of immediate call... Department regulations. Note accounts are not savings accounts or savings deposits....

  19. 12 CFR 390.300 - Note account.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Note account. 390.300 Section 390.300 Banks and... Associations § 390.300 Note account. The term note account means a note, subject to the right of immediate call... Department regulations. Note accounts are not savings accounts or savings deposits....

  20. 30 CFR 250.300 - Pollution prevention.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 2 2012-07-01 2012-07-01 false Pollution prevention. 250.300 Section 250.300... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Pollution Prevention and Control § 250.300 Pollution prevention. (a) During the exploration, development, production, and transportation...

  1. 30 CFR 250.300 - Pollution prevention.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Pollution prevention. 250.300 Section 250.300... OPERATIONS IN THE OUTER CONTINENTAL SHELF Pollution Prevention and Control § 250.300 Pollution prevention. (a... pollution occurs as a result of operations conducted by or on behalf of the lessee and the pollution...

  2. 30 CFR 250.300 - Pollution prevention.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 30 Mineral Resources 2 2014-07-01 2014-07-01 false Pollution prevention. 250.300 Section 250.300... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Pollution Prevention and Control § 250.300 Pollution prevention. (a) During the exploration, development, production, and transportation...

  3. 30 CFR 250.300 - Pollution prevention.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 30 Mineral Resources 2 2013-07-01 2013-07-01 false Pollution prevention. 250.300 Section 250.300... AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Pollution Prevention and Control § 250.300 Pollution prevention. (a) During the exploration, development, production, and transportation...

  4. 30 CFR 250.300 - Pollution prevention.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 2 2011-07-01 2011-07-01 false Pollution prevention. 250.300 Section 250.300... INTERIOR OFFSHORE OIL AND GAS AND SULPHUR OPERATIONS IN THE OUTER CONTINENTAL SHELF Pollution Prevention and Control § 250.300 Pollution prevention. (a) During the exploration, development, production,...

  5. 45 CFR 2541.300 - Changes.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false Changes. 2541.300 Section 2541.300 Public Welfare... ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Changes, Property and Subawards § 2541.300 Changes. (a) General. Grantees and subgrantees are permitted to re...

  6. 45 CFR 2541.300 - Changes.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Changes. 2541.300 Section 2541.300 Public Welfare... ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND COOPERATIVE AGREEMENTS TO STATE AND LOCAL GOVERNMENTS Changes, Property and Subawards § 2541.300 Changes. (a) General. Grantees and subgrantees are permitted to re...

  7. 34 CFR 300.505 - Electronic mail.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Electronic mail. 300.505 Section 300.505 Education... DISABILITIES Procedural Safeguards Due Process Procedures for Parents and Children § 300.505 Electronic mail. A....508 by an electronic mail communication, if the public agency makes that option available....

  8. 14 CFR 1203.300 - General.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false General. 1203.300 Section 1203.300 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM Classification Principles and Considerations § 1203.300 General. In general, the types of...

  9. 50 CFR 300.37 - Radio monitoring.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Radio monitoring. 300.37 Section 300.37 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS South Pacific Tuna Fisheries § 300.37 Radio monitoring. The international distress frequency, 2.182...

  10. 34 CFR 300.326 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false 300.326 Section 300.326 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES... § 300.326...

  11. 34 CFR 300.326 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false 300.326 Section 300.326 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES... § 300.326...

  12. 34 CFR 300.326 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true 300.326 Section 300.326 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES... § 300.326...

  13. 34 CFR 300.326 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true 300.326 Section 300.326 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES... § 300.326...

  14. 34 CFR 300.326 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false 300.326 Section 300.326 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES... § 300.326...

  15. 42 CFR 436.300 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Scope. 436.300 Section 436.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... Medically Needy § 436.300 Scope. This subpart specifies the option for coverage of medically...

  16. 49 CFR 195.300 - Scope.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Scope. 195.300 Section 195.300 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... PIPELINE Pressure Testing § 195.300 Scope. This subpart prescribes minimum requirements for the...

  17. 30 CFR 75.300 - Scope.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Scope. 75.300 Section 75.300 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR COAL MINE SAFETY AND HEALTH MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Ventilation § 75.300 Scope. This subpart sets requirements for...

  18. 42 CFR 435.300 - Scope.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Scope. 435.300 Section 435.300 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL... AMERICAN SAMOA Optional Coverage of the Medically Needy § 435.300 Scope. This subpart specifies the...

  19. 14 CFR 300.20 - Violations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 4 2013-01-01 2013-01-01 false Violations. 300.20 Section 300.20... REGULATIONS RULES OF CONDUCT IN DOT PROCEEDINGS UNDER THIS CHAPTER § 300.20 Violations. (a) DOT may disqualify... unethical or improper professional conduct. Any violation of this part shall be deemed to be such...

  20. 14 CFR 300.20 - Violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 4 2014-01-01 2014-01-01 false Violations. 300.20 Section 300.20... REGULATIONS RULES OF CONDUCT IN DOT PROCEEDINGS UNDER THIS CHAPTER § 300.20 Violations. (a) DOT may disqualify... unethical or improper professional conduct. Any violation of this part shall be deemed to be such...

  1. 14 CFR 300.20 - Violations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Violations. 300.20 Section 300.20... REGULATIONS RULES OF CONDUCT IN DOT PROCEEDINGS UNDER THIS CHAPTER § 300.20 Violations. (a) DOT may disqualify... unethical or improper professional conduct. Any violation of this part shall be deemed to be such...

  2. 14 CFR 300.20 - Violations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 4 2012-01-01 2012-01-01 false Violations. 300.20 Section 300.20... REGULATIONS RULES OF CONDUCT IN DOT PROCEEDINGS UNDER THIS CHAPTER § 300.20 Violations. (a) DOT may disqualify... unethical or improper professional conduct. Any violation of this part shall be deemed to be such...

  3. 14 CFR 300.20 - Violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 4 2011-01-01 2011-01-01 false Violations. 300.20 Section 300.20... REGULATIONS RULES OF CONDUCT IN DOT PROCEEDINGS UNDER THIS CHAPTER § 300.20 Violations. (a) DOT may disqualify... unethical or improper professional conduct. Any violation of this part shall be deemed to be such...

  4. 50 CFR 300.96 - Penalties.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Penalties. 300.96 Section 300.96 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Fraser River Sockeye and Pink Salmon Fisheries § 300.96 Penalties. Any treaty Indian who commits any act...

  5. 50 CFR 300.96 - Penalties.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 50 Wildlife and Fisheries 11 2014-10-01 2014-10-01 false Penalties. 300.96 Section 300.96 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Fraser River Sockeye and Pink Salmon Fisheries § 300.96 Penalties. Any treaty Indian who commits any act...

  6. 50 CFR 300.96 - Penalties.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 50 Wildlife and Fisheries 11 2012-10-01 2012-10-01 false Penalties. 300.96 Section 300.96 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Fraser River Sockeye and Pink Salmon Fisheries § 300.96 Penalties. Any treaty Indian who commits any act...

  7. 50 CFR 300.96 - Penalties.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 50 Wildlife and Fisheries 9 2011-10-01 2011-10-01 false Penalties. 300.96 Section 300.96 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Fraser River Sockeye and Pink Salmon Fisheries § 300.96 Penalties. Any treaty Indian who commits any act...

  8. 50 CFR 300.96 - Penalties.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 50 Wildlife and Fisheries 11 2013-10-01 2013-10-01 false Penalties. 300.96 Section 300.96 Wildlife and Fisheries INTERNATIONAL FISHING AND RELATED ACTIVITIES INTERNATIONAL FISHERIES REGULATIONS Fraser River Sockeye and Pink Salmon Fisheries § 300.96 Penalties. Any treaty Indian who commits any act...

  9. 34 CFR 300.716 - Applicable regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Applicable regulations. 300.716 Section 300.716 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... Secretary of the Interior § 300.716 Applicable regulations. The Secretary of the Interior must comply...

  10. 34 CFR 300.716 - Applicable regulations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Applicable regulations. 300.716 Section 300.716 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... Secretary of the Interior § 300.716 Applicable regulations. The Secretary of the Interior must comply...

  11. 34 CFR 300.716 - Applicable regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Applicable regulations. 300.716 Section 300.716 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... Secretary of the Interior § 300.716 Applicable regulations. The Secretary of the Interior must comply...

  12. 34 CFR 300.716 - Applicable regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Applicable regulations. 300.716 Section 300.716 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION... Secretary of the Interior § 300.716 Applicable regulations. The Secretary of the Interior must comply...

  13. 34 CFR 300.16 - Excess costs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Excess costs. 300.16 Section 300.16 Education... DISABILITIES General Definitions Used in This Part § 300.16 Excess costs. Excess costs means those costs that... for an example of how excess costs must be calculated.) (Authority: 20 U.S.C. 1401(8))...

  14. 34 CFR 300.16 - Excess costs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Excess costs. 300.16 Section 300.16 Education... DISABILITIES General Definitions Used in This Part § 300.16 Excess costs. Excess costs means those costs that... for an example of how excess costs must be calculated.) (Authority: 20 U.S.C. 1401(8))...

  15. 34 CFR 300.184 - Judicial review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Judicial review. 300.184 Section 300.184 Education... DISABILITIES State Eligibility Department Procedures § 300.184 Judicial review. If a State is dissatisfied with... Court of Appeals for the circuit in which that State is located a petition for review of that...

  16. 34 CFR 300.197 - Judicial review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Judicial review. 300.197 Section 300.197 Education... DISABILITIES State Eligibility By-Pass for Children in Private Schools § 300.197 Judicial review. If... petition for review with the United States Court of Appeals for the circuit in which the State is...

  17. 34 CFR 300.184 - Judicial review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Judicial review. 300.184 Section 300.184 Education... DISABILITIES State Eligibility Department Procedures § 300.184 Judicial review. If a State is dissatisfied with... Court of Appeals for the circuit in which that State is located a petition for review of that...

  18. 46 CFR 148.300 - Radioactive materials.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... radioactive materials defined in 49 CFR 173.403 as Low Specific Activity Material, LSA-1, or Surface... 46 Shipping 5 2013-10-01 2013-10-01 false Radioactive materials. 148.300 Section 148.300 Shipping... MATERIALS THAT REQUIRE SPECIAL HANDLING Special Requirements for Certain Materials § 148.300...

  19. 46 CFR 148.300 - Radioactive materials.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... radioactive materials defined in 49 CFR 173.403 as Low Specific Activity Material, LSA-1, or Surface... 46 Shipping 5 2014-10-01 2014-10-01 false Radioactive materials. 148.300 Section 148.300 Shipping... MATERIALS THAT REQUIRE SPECIAL HANDLING Special Requirements for Certain Materials § 148.300...

  20. 40 CFR 300.165 - OSC reports.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 27 2010-07-01 2010-07-01 false OSC reports. 300.165 Section 300.165 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SUPERFUND, EMERGENCY PLANNING, AND... Responsibility and Organization for Response § 300.165 OSC reports. (a) As requested by the NRT or RRT, the...

  1. 50 CFR 300.141 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 7 2010-10-01 2010-10-01 false Definitions. 300.141 Section 300.141... United States-Canada Fisheries Enforcement § 300.141 Definitions. In addition to the terms defined in... definition in this section applies. Applicable Canadian fisheries law means any Canadian law, regulation...

  2. 34 CFR 300.7 - Charter school.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Charter school. 300.7 Section 300.7 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.7 Charter school. Charter school has the meaning...

  3. 34 CFR 300.13 - Elementary school.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Elementary school. 300.13 Section 300.13 Education... DISABILITIES General Definitions Used in This Part § 300.13 Elementary school. Elementary school means a nonprofit institutional day or residential school, including a public elementary charter school,...

  4. 34 CFR 300.36 - Secondary school.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Secondary school. 300.36 Section 300.36 Education... DISABILITIES General Definitions Used in This Part § 300.36 Secondary school. Secondary school means a nonprofit institutional day or residential school, including a public secondary charter school that...

  5. 34 CFR 300.15 - Evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Evaluation. 300.15 Section 300.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.15 Evaluation. Evaluation means procedures used...

  6. 34 CFR 300.15 - Evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Evaluation. 300.15 Section 300.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.15 Evaluation. Evaluation means procedures used...

  7. 34 CFR 300.15 - Evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Evaluation. 300.15 Section 300.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.15 Evaluation. Evaluation means procedures used...

  8. 34 CFR 300.122 - Evaluation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Evaluation. 300.122 Section 300.122 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Additional Eligibility Requirements § 300.122 Evaluation. Children...

  9. 34 CFR 300.122 - Evaluation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Evaluation. 300.122 Section 300.122 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Additional Eligibility Requirements § 300.122 Evaluation. Children...

  10. 34 CFR 300.304 - Evaluation procedures.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Evaluation procedures. 300.304 Section 300.304... CHILDREN WITH DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and Educational Placements Evaluations and Reevaluations § 300.304 Evaluation procedures. (a) Notice. The...

  11. 34 CFR 300.301 - Initial evaluations.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Initial evaluations. 300.301 Section 300.301 Education... DISABILITIES Evaluations, Eligibility Determinations, Individualized Education Programs, and Educational Placements Evaluations and Reevaluations § 300.301 Initial evaluations. (a) General. Each public agency...

  12. 34 CFR 300.122 - Evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Evaluation. 300.122 Section 300.122 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Additional Eligibility Requirements § 300.122 Evaluation. Children...

  13. 34 CFR 300.122 - Evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Evaluation. 300.122 Section 300.122 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Additional Eligibility Requirements § 300.122 Evaluation. Children...

  14. 34 CFR 300.15 - Evaluation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Evaluation. 300.15 Section 300.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.15 Evaluation. Evaluation means procedures used...

  15. 34 CFR 300.122 - Evaluation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Evaluation. 300.122 Section 300.122 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES State Eligibility Additional Eligibility Requirements § 300.122 Evaluation. Children...

  16. 34 CFR 300.15 - Evaluation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Evaluation. 300.15 Section 300.15 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND... DISABILITIES General Definitions Used in This Part § 300.15 Evaluation. Evaluation means procedures used...

  17. 50 CFR 300.61 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... community listed in the table at § 300.65(g)(1) and who has maintained a domicile in rural communities listed in the table at § 300.65(g)(1), or in rural areas described at § 300.65(g)(3), for the 12... claiming residency in another state, territory, or country; or (2) An individual domiciled in a rural...

  18. 34 CFR 300.606 - Public attention.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Public attention. 300.606 Section 300.606 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND..., and Enforcement § 300.606 Public attention. Whenever a State receives notice that the Secretary...

  19. 34 CFR 300.606 - Public attention.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Public attention. 300.606 Section 300.606 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND..., and Enforcement § 300.606 Public attention. Whenever a State receives notice that the Secretary...

  20. 34 CFR 300.606 - Public attention.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Public attention. 300.606 Section 300.606 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND..., and Enforcement § 300.606 Public attention. Whenever a State receives notice that the Secretary...