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Sample records for 21h qualification samples

  1. Sample results from the interim salt disposition program macrobatch 9 tank 21H qualification samples

    SciTech Connect

    Peters, T. B.

    2015-11-01

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 9 for the Interim Salt Disposition Program (ISDP). This document reports characterization data on the samples of Tank 21H.

  2. Sample Results from the Interim Salt Disposition Program Macrobatch 6 Tank 21H Qualification Samples

    SciTech Connect

    Peters, T. B.; Fink, S. D.

    2012-12-11

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 6 for the Interim Salt Disposition Project (ISDP). This document reports partial results of the analyses of samples of Tank 21H. No issues with the projected Salt Batch 6 strategy are identified.

  3. Sample Results From The Interim Salt Disposition Program Macrobatch 6 Tank 21H Qualification Samples

    SciTech Connect

    Peters, T. B.; Fink, S. D.

    2012-12-20

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 6 for the Interim Salt Disposition Project (ISDP). This document reports partial results of the analyses of samples of Tank 21H. No issues with the projected Salt Batch 6 strategy are identified.

  4. SAMPLE RESULTS FROM THE INTEGRATED SALT DISPOSITION PROGRAM MACROBATCH 5 TANK 21H QUALIFICATION SAMPLES

    SciTech Connect

    Peters, T.; Fink, S.

    2012-03-26

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 5 for the Integrated Salt Disposition Project (ISDP). This document reports partial results of the analyses of samples of Tank 21H. No issues with the projected Salt Batch 5 strategy are identified. Results of the analyses of the Tank 21H samples from this report in conjunction with the findings of the previous report, indicates that the material does not display any unusual characteristics.

  5. RESULTS OF INITIAL ANALYSES OF THE MACROBATCH 5 TANK 21H QUALIFICATION SAMPLES

    SciTech Connect

    Peters, T.; Fink, S.

    2012-01-31

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Salt (Macro)Batch 5 for the Integrated Salt Disposition Project (ISDP). This document reports the initial results of the analyses of samples of Tank 21H. No issues with the projected Salt Batch 5 strategy are identified. This report describes the laboratory results of Salt (Macro)Batch 5 preliminary samples from Tank 21H. These results will be used by Tank Farm Engineering for their blend calculations. This work was specified by Technical Task Request (TTR) and by Task Technical and Quality Assurance Plan (TTQAP).

  6. Results of initial analyses of the salt (macro) batch 9 tank 21H qualification samples

    SciTech Connect

    Peters, T. B.

    2015-10-01

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Interim Salt Disposition Project (ISDP) Salt (Macro) Batch 9 for processing through the Actinide Removal Process (ARP) and the Modular Caustic-Side Solvent Extraction Unit (MCU). This document reports the initial results of the analyses of samples of Tank 21H. Analysis of the Tank 21H Salt (Macro) Batch 9 composite sample indicates that the material does not display any unusual characteristics or observations, such as floating solids, the presence of large amount of solids, or unusual colors. Further results on the chemistry and other tests will be issued in the future.

  7. Results Of Initial Analyses Of The Salt (Macro) Batch 9 Tank 21H Qualification Samples

    SciTech Connect

    Peters, T.

    2015-10-08

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Interim Salt Disposition Project (ISDP) Salt (Macro) Batch 9 for processing through the Actinide Removal Process (ARP) and the Modular Caustic-Side Solvent Extraction Unit (MCU). This document reports the initial results of the analyses of samples of Tank 21H. Analysis of the Tank 21H Salt (Macro) Batch 9 composite sample indicates that the material does not display any unusual characteristics. Further results on the chemistry and other tests will be issued in the future.

  8. SAMPLE RESULTS FROM THE INTEGRATED SALT DISPOSITION PROGRAM MACROBATCH 4 TANK 21H QUALIFICATION SAMPLES

    SciTech Connect

    Peters, T.; Fink, S.

    2011-06-22

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H to qualify them for use in the Integrated Salt Disposition Program (ISDP) Batch 4 processing. All sample results agree with expectations based on prior analyses where available. No issues with the projected Salt Batch 4 strategy are identified. This revision includes additional data points that were not available in the original issue of the document, such as additional plutonium results, the results of the monosodium titanate (MST) sorption test and the extraction, scrub strip (ESS) test. This report covers the revision to the Tank 21H qualification sample results for Macrobatch (Salt Batch) 4 of the Integrated Salt Disposition Program (ISDP). A previous document covers initial characterization which includes results for a number of non-radiological analytes. These results were used to perform aluminum solubility modeling to determine the hydroxide needs for Salt Batch 4 to prevent the precipitation of solids. Sodium hydroxide was then added to Tank 21 and additional samples were pulled for the analyses discussed in this report. This work was specified by Task Technical Request and by Task Technical and Quality Assurance Plan (TTQAP).

  9. Results Of Initial Analyses Of The Macrobatch 7 Tank 21H Qualification Samples

    SciTech Connect

    Peters, T. B.; Washington, A. L. II

    2013-07-08

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Salt (Macro) Batch 7 for the Interim Salt Disposition Program (ISDP) through ARP/MCU. This document reports the initial results of the analyses of samples of Tank 21H. Further results on the chemistry and other tests will be issued in the future. No issues with the projected Salt Batch 7 strategy are identified, other than the presence of visible quantities of dark colored solids. Based upon a SRNL settling test, the solids should settle well within the months-long settling period to be employed in Tank 21H. However, SRNL recommends analyzing the solids to provide input to OLI modeling in order to evaluate the impacts of these solids to present and future salt batches.

  10. SAMPLE RESULTS FROM THE INTERIM SALT DISPOSITION PROGRAM MACROBATCH 8 TANK 21H QUALIFICATION SAMPLES

    SciTech Connect

    Peters, T. B.; Washington, A. L.

    2015-01-13

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 8 for the Interim Salt Disposition Program (ISDP). An Actinide Removal Process (ARP) and several Extraction-Scrub- Strip (ESS) tests were also performed. This document reports characterization data on the samples of Tank 21H as well as simulated performance of ARP and the Modular Caustic Side Solvent Extraction (CSSX) Unit (MCU). No issues with the projected Salt Batch 8 strategy are identified. A demonstration of the monosodium titanate (MST) (0.2 g/L) removal of strontium and actinides provided acceptable average decontamination factors for plutonium of 2.62 (4 hour) and 2.90 (8 hour); and average strontium decontamination factors of 21.7 (4 hour) and 21.3 (8 hour). These values are consistent with results from previous salt batch ARP tests. The two ESS tests also showed acceptable performance with extraction distribution ratios (D{sub (Cs)}) values of 52.5 and 50.4 for the Next Generation Solvent (NGS) blend (from MCU) and NGS (lab prepared), respectively. These values are consistent with results from previous salt batch ESS tests. Even though the performance is acceptable, SRNL recommends that a model for predicting extraction behavior for cesium removal for the blended solvent and NGS be developed in order to improve our predictive capabilities for the ESS tests.

  11. Sample Results From The Interim Salt Disposition Program Macrobatch 7 Tank 21H Qualification Samples

    SciTech Connect

    Peters, T. B.; Washington, A. L. II

    2013-08-08

    Savannah River National Laboratory (SRNL) analyzed samples from Tank 21H in support of qualification of Macrobatch (Salt Batch) 7 for the Interim Salt Disposition Program (ISDP). An ARP and several ESS tests were also performed. This document reports characterization data on the samples of Tank 21H as well as simulated performance of ARP/MCU. No issues with the projected Salt Batch 7 strategy are identified, other than the presence of visible quantities of dark colored solids. A demonstration of the monosodium titanate (0.2 g/L) removal of strontium and actinides provided acceptable 4 hour average decontamination factors for Pu and Sr of 3.22 and 18.4, respectively. The Four ESS tests also showed acceptable behavior with distribution ratios (D(Cs)) values of 15.96, 57.1, 58.6, and 65.6 for the MCU, cold blend, hot blend, and Next Generation Solvent (NGS), respectively. The predicted value for the MCU solvent was 13.2. Currently, there are no models that would allow a prediction of extraction behavior for the other three solvents. SRNL recommends that a model for predicting extraction behavior for cesium removal for the blended solvent and NGS be developed. While no outstanding issues were noted, the presence of solids in the samples should be investigated in future work. It is possible that the solids may represent a potential reservoir of material (such as potassium) that could have an impact on MCU performance if they were to dissolve back into the feed solution. This salt batch is intended to be the first batch to be processed through MCU entirely using the new NGS-MCU solvent.

  12. SAMPLE RESULTS FROM THE INTEGRATED SALT DISPOSITION PROGRAM MACROBATCH 5 TANK 21H QUALIFICATION MST, ESS AND PODD SAMPLES

    SciTech Connect

    Peters, T.; Fink, S.

    2012-04-24

    Savannah River National Laboratory (SRNL) performed experiments on qualification material for use in the Integrated Salt Disposition Program (ISDP) Batch 5 processing. This qualification material was a composite created from recent samples from Tank 21H and archived samples from Tank 49H to match the projected blend from these two tanks. Additionally, samples of the composite were used in the Actinide Removal Process (ARP) and extraction-scrub-strip (ESS) tests. ARP and ESS test results met expectations. A sample from Tank 21H was also analyzed for the Performance Objectives Demonstration Document (PODD) requirements. SRNL was able to meet all of the requirements, including the desired detection limits for all the PODD analytes. This report details the results of the Actinide Removal Process (ARP), Extraction-Scrub-Strip (ESS) and Performance Objectives Demonstration Document (PODD) samples of Macrobatch (Salt Batch) 5 of the Integrated Salt Disposition Program (ISDP).

  13. Sample Results From The Interim Salt Disposition Program Macrobatch 7 Tank 21H Qualification MST Solids Sample

    SciTech Connect

    Washington, A. L. II; Peters, T. B.

    2013-09-19

    Savannah River National Laboratory (SRNL) performed experiments on qualification material for use in the Interim Salt Disposition Program (ISDP) Batch 7 processing. The Marcrobatch 7 material was received with visible fine particulate solids, atypical for these samples. The as received material was allowed to settle for a period greater than 24 hours. The supernatant was then decanted and utilized as our clarified feed material. As part of this qualification work, SRNL performed an Actinide Removal Process (ARP) test using the clarified feed material. From this test, the residual monosodium titanate (MST) was analyzed for radionuclide uptake after filtration from H-Tank Farm (HTF) feed salt solution. The results of these analyses are reported and are within historical precedent.

  14. Sample results from the integrated salt disposition program macrobatch 6 tank 21H qualifications MST solids sample

    SciTech Connect

    Peters, T. B.

    2013-02-26

    Savannah River National Laboratory (SRNL) performed experiments on qualification material for use in the Integrated Salt Disposition Program (ISDP) Batch 6 processing. As part of this qualification work, SRNL performed an Actinide Removal Process (ARP) test. From this test, the residual monosodium titanate (MST) was analyzed for radionuclide uptake. The results of these analyses are reported and are within historical precedent.

  15. Interim salt disposition program macrobatch 6 tank 21H qualification monosodium titanate and cesium mass transfer tests

    SciTech Connect

    Washington, A. L. II; Peters, T. B.; Fink, S. D.

    2013-02-25

    Savannah River National Laboratory (SRNL) performed experiments on qualification material for use in the Interim Salt Disposition Program (ISDP) Batch 6 processing. This qualification material was a set of six samples from Tank 21H in October 2012. This sample was used as a real waste demonstration of the Actinide Removal Process (ARP) and the Extraction-Scrub-Strip (ESS) tests process. The Tank 21H sample was contacted with a reduced amount (0.2 g/L) of MST and characterized for strontium and actinide removal at 0 and 8 hour time intervals in this salt batch. {sup 237}Np and {sup 243}Am were both observed to be below detection limits in the source material, and so these results are not reported in this report. The plutonium and uranium samples had decontamination factor (DF) values that were on par or slightly better than we expected from Batch 5. The strontium DF values are slightly lower than expected but still in an acceptable range. The Extraction, Scrub, and Strip (ESS) testing demonstrated cesium removal, stripping and scrubbing within the acceptable range. Overall, the testing indicated that cesium removal is comparable to prior batches at MCU.

  16. DNA Qualification Workflow for Next Generation Sequencing of Histopathological Samples

    PubMed Central

    Simbolo, Michele; Gottardi, Marisa; Corbo, Vincenzo; Fassan, Matteo; Mafficini, Andrea; Malpeli, Giorgio; Lawlor, Rita T.; Scarpa, Aldo

    2013-01-01

    Histopathological samples are a treasure-trove of DNA for clinical research. However, the quality of DNA can vary depending on the source or extraction method applied. Thus a standardized and cost-effective workflow for the qualification of DNA preparations is essential to guarantee interlaboratory reproducible results. The qualification process consists of the quantification of double strand DNA (dsDNA) and the assessment of its suitability for downstream applications, such as high-throughput next-generation sequencing. We tested the two most frequently used instrumentations to define their role in this process: NanoDrop, based on UV spectroscopy, and Qubit 2.0, which uses fluorochromes specifically binding dsDNA. Quantitative PCR (qPCR) was used as the reference technique as it simultaneously assesses DNA concentration and suitability for PCR amplification. We used 17 genomic DNAs from 6 fresh-frozen (FF) tissues, 6 formalin-fixed paraffin-embedded (FFPE) tissues, 3 cell lines, and 2 commercial preparations. Intra- and inter-operator variability was negligible, and intra-methodology variability was minimal, while consistent inter-methodology divergences were observed. In fact, NanoDrop measured DNA concentrations higher than Qubit and its consistency with dsDNA quantification by qPCR was limited to high molecular weight DNA from FF samples and cell lines, where total DNA and dsDNA quantity virtually coincide. In partially degraded DNA from FFPE samples, only Qubit proved highly reproducible and consistent with qPCR measurements. Multiplex PCR amplifying 191 regions of 46 cancer-related genes was designated the downstream application, using 40 ng dsDNA from FFPE samples calculated by Qubit. All but one sample produced amplicon libraries suitable for next-generation sequencing. NanoDrop UV-spectrum verified contamination of the unsuccessful sample. In conclusion, as qPCR has high costs and is labor intensive, an alternative effective standard workflow for

  17. DNA qualification workflow for next generation sequencing of histopathological samples.

    PubMed

    Simbolo, Michele; Gottardi, Marisa; Corbo, Vincenzo; Fassan, Matteo; Mafficini, Andrea; Malpeli, Giorgio; Lawlor, Rita T; Scarpa, Aldo

    2013-01-01

    Histopathological samples are a treasure-trove of DNA for clinical research. However, the quality of DNA can vary depending on the source or extraction method applied. Thus a standardized and cost-effective workflow for the qualification of DNA preparations is essential to guarantee interlaboratory reproducible results. The qualification process consists of the quantification of double strand DNA (dsDNA) and the assessment of its suitability for downstream applications, such as high-throughput next-generation sequencing. We tested the two most frequently used instrumentations to define their role in this process: NanoDrop, based on UV spectroscopy, and Qubit 2.0, which uses fluorochromes specifically binding dsDNA. Quantitative PCR (qPCR) was used as the reference technique as it simultaneously assesses DNA concentration and suitability for PCR amplification. We used 17 genomic DNAs from 6 fresh-frozen (FF) tissues, 6 formalin-fixed paraffin-embedded (FFPE) tissues, 3 cell lines, and 2 commercial preparations. Intra- and inter-operator variability was negligible, and intra-methodology variability was minimal, while consistent inter-methodology divergences were observed. In fact, NanoDrop measured DNA concentrations higher than Qubit and its consistency with dsDNA quantification by qPCR was limited to high molecular weight DNA from FF samples and cell lines, where total DNA and dsDNA quantity virtually coincide. In partially degraded DNA from FFPE samples, only Qubit proved highly reproducible and consistent with qPCR measurements. Multiplex PCR amplifying 191 regions of 46 cancer-related genes was designated the downstream application, using 40 ng dsDNA from FFPE samples calculated by Qubit. All but one sample produced amplicon libraries suitable for next-generation sequencing. NanoDrop UV-spectrum verified contamination of the unsuccessful sample. In conclusion, as qPCR has high costs and is labor intensive, an alternative effective standard workflow for

  18. Testing of Small Graphite Samples for Nuclear Qualification

    SciTech Connect

    Julie Chapman

    2010-11-01

    Accurately determining the mechanical properties of small irradiated samples is crucial to predicting the behavior of the overal irradiated graphite components within a Very High Temperature Reactor. The sample size allowed in a material test reactor, however, is limited, and this poses some difficulties with respect to mechanical testing. In the case of graphite with a larger grain size, a small sample may exhibit characteristics not representative of the bulk material, leading to inaccuracies in the data. A study to determine a potential size effect on the tensile strength was pursued under the Next Generation Nuclear Plant program. It focuses first on optimizing the tensile testing procedure identified in the American Society for Testing and Materials (ASTM) Standard C 781-08. Once the testing procedure was verified, a size effect was assessed by gradually reducing the diameter of the specimens. By monitoring the material response, a size effect was successfully identified.

  19. Tank 30 and 37 Supernatant Sample Cross-Check and Evaporator Feed Qualification Analysis-2012

    SciTech Connect

    Oji, L. N.

    2013-03-07

    This report summarizes the analytical data reported by the F/H and Savannah River National Laboratories for the 2012 cross-check analysis for high level waste supernatant liquid samples from SRS Tanks 30 and 37. The intent of this Tank 30 and 37 sample analyses was to perform cross-checks against routine F/H Laboratory analyses (corrosion and evaporator feed qualification programs) using samples collected at the same time from both tanks as well as split samples from the tanks.

  20. Characterization Of The As-Received Sludge Batch 9 Qualification Sample (Htf-51-15-81)

    SciTech Connect

    Pareizs, J.

    2015-09-30

    Savannah River National Laboratory (SRNL) personnel have been requested to qualify the next sludge batch (Sludge Batch 9 – SB9) for processing at the Defense Waste Processing Facility (DWPF). To accomplish this task, Savannah River Remediation (SRR) has sent SRNL a 3-L slurried sample of Tank 51H (HTF-51-15-81) to be characterized, washed, and then used in a lab-scale demonstration of the DWPF flowsheet (potentially after combining with Tank 40H sludge). This report documents the first steps of the qualification process – characterization of the as-received Tank 51H qualification sample. These results will be used to support a reprojection of SB9 by SRR from which final Tank 51H washing, frit development, and Chemical Processing Cell (CPC) activities will be based.

  1. Characterization of the SRNL-Washed tank 51 sludge batch 9 qualification sample

    SciTech Connect

    Pareizs, J. M.

    2016-01-01

    Savannah River National Laboratory (SRNL) personnel have been requested to qualify the next sludge batch (Sludge Batch 9 – SB9) for processing at the Defense Waste Processing Facility (DWPF). To accomplish this task, Savannah River Remediation (SRR) sent SRNL a 3-L sample of Tank 51H slurry to be characterized, washed, and then used in a lab-scale demonstration of the DWPF flowsheet (after combining with Tank 40H sludge). SRNL has washed the Tank 51H sample per the Tank Farm washing strategy as of October 20, 2015. A part of the qualification process is extensive radionuclide and chemical characterization of the SRNL-washed Tank 51H slurry. This report documents the chemical characterization of the washed slurry; radiological characterization is in progress and will be documented in a separate report. The analytical results of this characterization are comparable to the Tank Farm projections. Therefore, it is recommended that SRNL use this washed slurry for the ongoing SB9 qualification activities.

  2. Qualification Study of Two Genomic DNA Extraction Methods in Different Clinical Samples

    PubMed Central

    Javadi, Alireza; Shamaei, Masoud; Pourabdollah, Mihan; Dorudinia, Atosa; Seyedmehdi, Seyed Mohammad; Karimi, Shirin

    2014-01-01

    Introduction The purity of genomic DNA (gDNA) extracted from different clinical specimens optimizes sensitivity of polymerase chain reaction (PCR) assays. This study attempted to compare two different DNA extraction techniques namely salting-out and classic phenol-chloroform. Materials and Methods Qualification of two different DNA extraction techniques for 634 clinical specimens highly suspected of having mycobacterial infection was performed. Genomic DNA was extracted from 330 clinical samples using phenol-chloroform and 304 by non-toxic salting-out. Qualification of obtained gDNA was done through amplification of internal controls, β-actin and β-globin. Results β-actin-positive was detected in 279/330 (84%) and 272/304 (89%) samples by phenol-chloroform technique and salting-out, respectively. PCR inhibitor was found for the gDNA of 13/304 (4%) patient samples were negative by β-actin and β-globin tests via salting-out technique in comparison with gDNAs from 27/330 (8.5%) samples extracted by phenol-chloroform procedure. No statistically significant difference was found between phenol-chloroform technique and salting-out for 385 sputum, 29 bronchoalveolar lavage (BAL), 105 gastric washing, and 38 body fluid (P=0.04) samples. This illustrates that both techniques have the same quality for extracting gDNA. Conclusion This study discloses salting-out as a non-toxic DNA extraction procedure with a superior time-efficiency and cost-effectiveness in comparison with phenol-chloroform and it can be routinely used in resource-limited laboratory settings. PMID:25852760

  3. Results of the TF conductor performance qualification samples for the ITER project

    NASA Astrophysics Data System (ADS)

    Breschi, M.; Devred, A.; Casali, M.; Bessette, D.; Jewell, M. C.; Mitchell, N.; Pong, I.; Vostner, A.; Bruzzone, P.; Stepanov, B.; Boutboul, T.; Martovetsky, N.; Kim, K.; Takahashi, Y.; Tronza, V.; Yu, Wu

    2012-09-01

    The performance of the toroidal field (TF) magnet conductors for the ITER machine are qualified by a short full-size sample (4 m) current sharing temperature (Tcs) test in the SULTAN facility at CRPP in Villigen, Switzerland, using the operating current of 68 kA and the design peak field of 11.8 T. Several samples, including at least one from each of the six ITER Domestic Agencies participating in TF conductor fabrication (China, European Union, Japan, Russia, South Korea and the United States), have been qualified by the ITER Organization after achieving Tcs values of 6.0-6.9 K, after 700-1000 electromagnetic cycles. These Tcs values exceed the ITER specification and enabled the industrial production of these long-lead items for the ITER tokamak to begin in each Domestic Agency. Some of these samples did not pass the qualification test. In this paper, we summarize the performance of the qualified samples, analyze the effect of strand performance on conductor performance, and discuss the details of the test results.

  4. Performance analysis of the Nb-Ti conductor qualification samples for the ITER project

    NASA Astrophysics Data System (ADS)

    Breschi, M.; Carati, D.; Bessette, D.; Devred, A.; Romano, G.; Vostner, A.; Zhou, C.

    2015-11-01

    The ITER machine will require approximately 275 tons of Nb-Ti strands that will be used in poloidal field (PF) coils, correction coils (CC) and feeder busbars. The performance of all these conductors for the ITER machine is qualified by a short full-size sample (4 m) current sharing temperature (T cs) test in the SULTAN facility at CRPP in Villigen, Switzerland, at the design operating current and peak field. Three ITER domestic agencies participated in PF conductor fabrication (China, the European Union, Russia) while the conductors for feeder busbars and correction coils are entirely produced by the Chinese domestic agency. Each conductor type was qualified by the ITER International Organization after reaching T cs values in excess of ITER specifications. This qualification enabled the launch of procurement and industrial production of the Nb-Ti cable-in-conduit conductors in each domestic agency. In this paper, we summarize the performance of the qualified Nb-Ti samples of the ITER Project, comparing strand performance with conductor performance. The details of the test results will be discussed in terms of dc performance, ac losses and minimum quench energies of each conductor type.

  5. ELIMINATION OF THE CHARACTERIZATION OF DWPF POUR STREAM SAMPLE AND THE GLASS FABRICATION AND TESTING OF THE DWPF SLUDGE BATCH QUALIFICATION SAMPLE

    SciTech Connect

    Amoroso, J.; Peeler, D.; Edwards, T.

    2012-05-11

    A recommendation to eliminate all characterization of pour stream glass samples and the glass fabrication and Product Consistency Test (PCT) of the sludge batch qualification sample was made by a Six-Sigma team chartered to eliminate non-value-added activities for the Defense Waste Processing Facility (DWPF) sludge batch qualification program and is documented in the report SS-PIP-2006-00030. That recommendation was supported through a technical data review by the Savannah River National Laboratory (SRNL) and is documented in the memorandums SRNL-PSE-2007-00079 and SRNL-PSE-2007-00080. At the time of writing those memorandums, the DWPF was processing sludge-only waste but, has since transitioned to a coupled operation (sludge and salt). The SRNL was recently tasked to perform a similar data review relevant to coupled operations and re-evaluate the previous recommendations. This report evaluates the validity of eliminating the characterization of pour stream glass samples and the glass fabrication and Product Consistency Test (PCT) of the sludge batch qualification samples based on sludge-only and coupled operations. The pour stream sample has confirmed the DWPF's ability to produce an acceptable waste form from Slurry Mix Evaporator (SME) blending and product composition/durability predictions for the previous sixteen years but, ultimately the pour stream analysis has added minimal value to the DWPF's waste qualification strategy. Similarly, the information gained from the glass fabrication and PCT of the sludge batch qualification sample was determined to add minimal value to the waste qualification strategy since that sample is routinely not representative of the waste composition ultimately processed at the DWPF due to blending and salt processing considerations. Moreover, the qualification process has repeatedly confirmed minimal differences in glass behavior from actual radioactive waste to glasses fabricated from simulants or batch chemicals. In contrast, the

  6. JOB BRIEFS, SELECTED FEDERAL JOBS--DUTIES, QUALIFICATION REQUIREMENTS, SAMPLE TEST QUESTIONS.

    ERIC Educational Resources Information Center

    Civil Service Commission, Washington, DC.

    INFORMATION ABOUT JOBS IN THE FEDERAL GOVERNMENT FOR PERSONS WITH LIMITED WORK EXPERIENCE OR EDUCATION IS PROVIDED. JOB BRIEFS DESCRIBING THE WORK, OPPORTUNITIES, NUMBER EMPLOYED, EMPLOYING AGENCIES, AND QUALIFICATIONS ARE GIVEN FOR (1) 19 WHITE COLLAR AND POST OFFICE JOBS SUCH AS CLERK-TYPIST, CLERK-STENOGRAPHER, NURSING ASSISTANT, SOIL…

  7. SLUDGE BATCH 7 ACCEPTANCE EVALUATION: RADIONUCLIDE CONCENTRATIONS IN TANK 51 SB7 QUALIFICATION SAMPLE PREPARED AT SRNL

    SciTech Connect

    Pareizs, J.; Hay, M.

    2011-02-22

    Presented in this report are radionuclide concentrations required as part of the program of qualifying Sludge Batch Seven (SB7) for processing in the Defense Waste Processing Facility (DWPF). The SB7 material is currently in Tank 51 being washed and prepared for transfer to Tank 40. The acceptance evaluation needs to be completed prior to the transfer of the material in Tank 51 to Tank 40. The sludge slurry in Tank 40 has already been qualified for DWPF and is currently being processed as SB6. The radionuclide concentrations were measured or estimated in the Tank 51 SB7 Qualification Sample prepared at Savannah River National Laboratory (SRNL). This sample was prepared from the three liter qualification sample of Tank 51 sludge slurry (HTF-51-10-125) received on September 18, 2010. The sample was delivered to SRNL where it was initially characterized in the Shielded Cells. With consultation from the Liquid Waste Organization, the qualification sample was then modified by several washes and decants, which included addition of Pu from H Canyon and sodium nitrite per the Tank Farm corrosion control program. This final slurry now has a composition expected to be similar to that of the slurry in Tank 51 after final preparations have been made for transfer of that slurry to Tank 40. Determining the radionuclide concentrations in this Tank 51 SB7 Qualification Sample is part of the work requested in Technical Task Request (TTR) No. HLW-DWPF-TTR-2010-0031. The radionuclides included in this report are needed for the DWPF Radiological Program Evaluation, the DWPF Waste Acceptance Criteria (TSR/WAC) Evaluation, and the DWPF Solid Waste Characterization Program (TTR Task I.2). Radionuclides required to meet the Waste Acceptance Product Specifications (TTR Task III.2.) will be measured at a later date after the slurry from Tank 51 has been transferred to Tank 40. Then a sample of the as-processed SB7 will be taken and transferred to SRNL for measurement of these radionuclides

  8. Verification Of The Defense Waste Processing Facility's (DWPF) Process Digestion Methods For The Sludge Batch 8 Qualification Sample

    SciTech Connect

    Click, D. R.; Edwards, T. B.; Wiedenman, B. J.; Brown, L. W.

    2013-03-18

    This report contains the results and comparison of data generated from inductively coupled plasma – atomic emission spectroscopy (ICP-AES) analysis of Aqua Regia (AR), Sodium Peroxide/Sodium Hydroxide Fusion Dissolution (PF) and Cold Chem (CC) method digestions and Cold Vapor Atomic Absorption analysis of Hg digestions from the DWPF Hg digestion method of Sludge Batch 8 (SB8) Sludge Receipt and Adjustment Tank (SRAT) Receipt and SB8 SRAT Product samples. The SB8 SRAT Receipt and SB8 SRAT Product samples were prepared in the SRNL Shielded Cells, and the SRAT Receipt material is representative of the sludge that constitutes the SB8 Batch or qualification composition. This is the sludge in Tank 51 that is to be transferred into Tank 40, which will contain the heel of Sludge Batch 7b (SB7b), to form the SB8 Blend composition.

  9. VERIFICATION OF THE DEFENSE WASTE PROCESSING FACILITY'S (DWPF) PROCESS DIGESTION METHOD FOR THE SLUDGE BATCH 7A QUALIFICATION SAMPLE

    SciTech Connect

    Click, D.; Edwards, T.; Jones, M.; Wiedenman, B.

    2011-03-14

    For each sludge batch that is processed in the Defense Waste Processing Facility (DWPF), the Savannah River National Laboratory (SRNL) performs confirmation of the applicability of the digestion method to be used by the DWPF lab for elemental analysis of Sludge Receipt and Adjustment Tank (SRAT) receipt samples and SRAT product process control samples. DWPF SRAT samples are typically dissolved using a room temperature HF-HNO{sub 3} acid dissolution (i.e., DWPF Cold Chem Method, see DWPF Procedure SW4-15.201) and then analyzed by inductively coupled plasma - atomic emission spectroscopy (ICP-AES). This report contains the results and comparison of data generated from performing the Aqua Regia (AR), Sodium peroxide/Hydroxide Fusion (PF) and DWPF Cold Chem (CC) method digestions of Sludge Batch 7a (SB7a) SRAT Receipt and SB7a SRAT Product samples. The SB7a SRAT Receipt and SB7a SRAT Product samples were prepared in the SRNL Shielded Cells, and the SRAT Receipt material is representative of the sludge that constituates the SB7a Batch or qualification composition. This is the sludge in Tank 51 that is to be transferred into Tank 40, which will contain the heel of Sludge Batch 6 (SB6), to form the Sb7a Blend composition.

  10. SLUDGE BATCH 6 ACCEPTANCE EVALUATION: RADIONUCLIDE CONCENTRATIONS IN TANK 51 SB6 QUALIFICATION SAMPLE PREPARED AT SRNL

    SciTech Connect

    Bannochie, C.; Bibler, N.; Diprete, D.

    2010-05-21

    Presented in this report are radionuclide concentrations required as part of the program of qualifying Sludge Batch Six (SB6) for processing in the Defense Waste Processing Facility (DWPF). The SB6 material is currently in Tank 51 being washed and prepared for transfer to Tank 40. The acceptance evaluation needs to be completed prior to the transfer of the material in Tank 51 to Tank 40. The sludge slurry in Tank 40 has already been qualified for DWPF and is currently being processed as SB5. The radionuclide concentrations were measured or estimated in the Tank 51 SB6 Qualification Sample prepared at Savannah River National Laboratory (SRNL). This sample was prepared from the three liter sample of Tank 51 sludge slurry (HTF-51-09-110) taken on October 8, 2009. The sample was delivered to SRNL where it was initially characterized in the Shielded Cells. Under the direction of the Liquid Waste Organization it was then modified by eight washes, nine decants, an addition of Pu from Canyon Tank 16.3, and an addition of NaNO{sub 2}. This final slurry now has a composition expected to be similar to that of the slurry in Tank 51 after final preparations have been made for transfer of that slurry to Tank 40. Determining the radionuclide concentrations in this Tank 51 SB6 Qualification Sample is part of the work requested in Technical Task Request (TTR) No. HLW-DWPF-TTR-2009-0014. The work with this qualification sample is covered by a Task Technical and Quality Assurance Plan and an Analytical Study Plan. The radionuclides included in this report are needed for the DWPF Radiological Program Evaluation, the DWPF Waste Acceptance Criteria (TSR/WAC) Evaluation, and the DWPF Solid Waste Characterization Program (TTR Task I.2). Radionuclides required to meet the Waste Acceptance Product Specifications (TTR Task II.2.) will be measured at a later date after the slurry from Tank 51 has been transferred to Tank 40. Then a sample of the as-processed SB6 will be taken and transferred

  11. GUM Analysis for TIMS Isotopic Ratios in BEP0 Graphite Qualification Samples, Round 2

    SciTech Connect

    Gerlach, David C.; Heasler, Patrick G.; Reid, Bruce D.

    2009-01-01

    In May 2007, one set of three samples from NBL were addressed to Steve Petersen for TIMS analysis, and included BEP0 samples numbered 27008, 30986, and 50846. All cores were trimmed by tooling, and lightly cleaned by CO2 pellet blasting. Small discs were cut from the second set of samples for SIMS analysis, with the remainder of each used for TIMS preparation.

  12. Effect of measurement error budgets and hybrid metrology on qualification metrology sampling

    NASA Astrophysics Data System (ADS)

    Sendelbach, Matthew; Sarig, Niv; Wakamoto, Koichi; Kim, Hyang Kyun (Helen); Isbester, Paul; Asano, Masafumi; Matsuki, Kazuto; Osorio, Carmen; Archie, Chas

    2014-10-01

    Until now, metrologists had no statistics-based method to determine the sampling needed for an experiment before the start that accuracy experiment. We show a solution to this problem called inverse total measurement uncertainty (TMU) analysis, by presenting statistically based equations that allow the user to estimate the needed sampling after providing appropriate inputs, allowing him to make important "risk versus reward" sampling, cost, and equipment decisions. Application examples using experimental data from scatterometry and critical dimension scanning electron microscope tools are used first to demonstrate how the inverse TMU analysis methodology can be used to make intelligent sampling decisions and then to reveal why low sampling can lead to unstable and misleading results. One model is developed that can help experimenters minimize sampling costs. A second cost model reveals the inadequacy of some current sampling practices-and the enormous costs associated with sampling that provides reasonable levels of certainty in the result. We introduce the strategies on how to manage and mitigate these costs and begin the discussion on how fabs are able to manufacture devices using minimal reference sampling when qualifying metrology steps. Finally, the relationship between inverse TMU analysis and hybrid metrology is explored.

  13. Impact of shrinking measurement error budgets on qualification metrology sampling and cost

    NASA Astrophysics Data System (ADS)

    Sendelbach, Matthew; Sarig, Niv; Wakamoto, Koichi; Kim, Hyang Kyun (Helen); Isbester, Paul; Asano, Masafumi; Matsuki, Kazuto; Vaid, Alok; Osorio, Carmen; Archie, Chas

    2014-04-01

    When designing an experiment to assess the accuracy of a tool as compared to a reference tool, semiconductor metrologists are often confronted with the situation that they must decide on the sampling strategy before the measurements begin. This decision is usually based largely on the previous experience of the metrologist and the available resources, and not on the statistics that are needed to achieve acceptable confidence limits on the final result. This paper shows a solution to this problem, called inverse TMU analysis, by presenting statistically-based equations that allow the user to estimate the needed sampling after providing appropriate inputs, allowing him to make important "risk vs. reward" sampling, cost, and equipment decisions. Application examples using experimental data from scatterometry and critical dimension scanning electron microscope (CD-SEM) tools are used first to demonstrate how the inverse TMU analysis methodology can be used to make intelligent sampling decisions before the start of the experiment, and then to reveal why low sampling can lead to unstable and misleading results. A model is developed that can help an experimenter minimize the costs associated both with increased sampling and with making wrong decisions caused by insufficient sampling. A second cost model is described that reveals the inadequacy of current TEM (Transmission Electron Microscopy) sampling practices and the enormous costs associated with TEM sampling that is needed to provide reasonable levels of certainty in the result. These high costs reach into the tens of millions of dollars for TEM reference metrology as the measurement error budgets reach angstrom levels. The paper concludes with strategies on how to manage and mitigate these costs.

  14. Analysis of tank 4 (FTF-4-15-22, 23) surface and subsurface supernatant samples in support of enrichment control, corrosion control and evaporator feed qualification programs

    SciTech Connect

    Oji, L. N.

    2015-09-09

    This report provides the results of analyses on Savannah River Site Tank 4 surface and subsurface supernatant liquid samples in support of the Enrichment Control Program (ECP), the Corrosion Control Program (CCP) and the Evaporator Feed Qualification (EFQ) Program. The purpose of the ECP sample taken from Tank 4 in August 2015 was to determine if the supernatant liquid would be “acceptable feed” to the 2H and 3H evaporator systems.

  15. 23 CFR 637.209 - Laboratory and sampling and testing personnel qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the FHWA. (3) After June 29, 2000, any non-STD designated laboratory which performs IA sampling and... testing data to be used in the acceptance decision or the IA program shall be executed by qualified... same project: Verification testing, quality control testing, IA testing, or dispute resolution testing....

  16. 23 CFR 637.209 - Laboratory and sampling and testing personnel qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the FHWA. (3) After June 29, 2000, any non-STD designated laboratory which performs IA sampling and... testing data to be used in the acceptance decision or the IA program shall be executed by qualified... same project: Verification testing, quality control testing, IA testing, or dispute resolution testing....

  17. DEFENSE WASTE PROCESSING FACILITY ANALYTICAL METHOD VERIFICATION FOR THE SLUDGE BATCH 5 QUALIFICATION SAMPLE

    SciTech Connect

    Click, D; Tommy Edwards, T; Henry Ajo, H

    2008-07-25

    For each sludge batch that is processed in the Defense Waste Processing Facility (DWPF), the Savannah River National Laboratory (SRNL) performs confirmation of the applicability of the digestion method to be used by the DWPF lab for elemental analysis of Sludge Receipt and Adjustment Tank (SRAT) receipt samples and SRAT product process control samples. DWPF SRAT samples are typically dissolved using a room temperature HF-HNO3 acid dissolution (i.e., DWPF Cold Chem Method, see Procedure SW4-15.201) and then analyzed by inductively coupled plasma - atomic emission spectroscopy (ICP-AES). This report contains the results and comparison of data generated from performing the Aqua Regia (AR), Sodium Peroxide/Hydroxide Fusion (PF) and DWPF Cold Chem (CC) method digestion of Sludge Batch 5 (SB5) SRAT Receipt and SB5 SRAT Product samples. The SB5 SRAT Receipt and SB5 SRAT Product samples were prepared in the SRNL Shielded Cells, and the SRAT Receipt material is representative of the sludge that constitutes the SB5 Batch composition. This is the sludge in Tank 51 that is to be transferred into Tank 40, which will contain the heel of Sludge Batch 4 (SB4), to form the SB5 Blend composition. The results for any one particular element should not be used in any way to identify the form or speciation of a particular element in the sludge or used to estimate ratios of compounds in the sludge. A statistical comparison of the data validates the use of the DWPF CC method for SB5 Batch composition. However, the difficulty that was encountered in using the CC method for SB4 brings into question the adequacy of CC for the SB5 Blend. Also, it should be noted that visible solids remained in the final diluted solutions of all samples digested by this method at SRNL (8 samples total), which is typical for the DWPF CC method but not seen in the other methods. Recommendations to the DWPF for application to SB5 based on studies to date: (1) A dissolution study should be performed on the WAPS

  18. VERIFICATION OF THE DEFENSE WASTE PROCESSING FACILITY PROCESS DIGESTION METHOD FOR THE SLUDGE BATCH 6 QUALIFICATION SAMPLE

    SciTech Connect

    Click, D.; Jones, M.; Edwards, T.

    2010-06-09

    For each sludge batch that is processed in the Defense Waste Processing Facility (DWPF), the Savannah River National Laboratory (SRNL) confirms applicability of the digestion method to be used by the DWPF lab for elemental analysis of Sludge Receipt and Adjustment Tank (SRAT) receipt samples and SRAT product process control samples.1 DWPF SRAT samples are typically dissolved using a room temperature HF-HNO3 acid dissolution (i.e., DWPF Cold Chem (CC) Method, see DWPF Procedure SW4-15.201) and then analyzed by inductively coupled plasma - atomic emission spectroscopy (ICPAES). In addition to the CC method confirmation, the DWPF lab's mercury (Hg) digestion method was also evaluated for applicability to SB6 (see DWPF procedure 'Mercury System Operating Manual', Manual: SW4-15.204. Section 6.1, Revision 5, Effective date: 12-04-03). This report contains the results and comparison of data generated from performing the Aqua Regia (AR), Sodium Peroxide/Hydroxide Fusion (PF) and DWPF Cold Chem (CC) method digestion of Sludge Batch 6 (SB6) SRAT Receipt and SB6 SRAT Product samples. For validation of the DWPF lab's Hg method, only SRAT receipt material was used and compared to AR digestion results. The SB6 SRAT Receipt and SB6 SRAT Product samples were prepared in the SRNL Shielded Cells, and the SRAT Receipt material is representative of the sludge that constitutes the SB6 Batch or qualification composition. This is the sludge in Tank 51 that is to be transferred into Tank 40, which will contain the heel of Sludge Batch 5 (SB5), to form the SB6 Blend composition. In addition to the 16 elements currently measured by the DWPF, this report includes Hg and thorium (Th) data (Th comprising {approx}2.5 - 3 Wt% of the total solids in SRAT Receipt and SRAT Product, respectively) and provides specific details of ICP-AES analysis of Th. Thorium was found to interfere with the U 367.007 nm emission line, and an inter-element correction (IEC) had to be applied to U data, which is also

  19. Thermal protection system development, testing, and qualification for atmospheric probes and sample return missions. Examples for Saturn, Titan and Stardust-type sample return

    NASA Astrophysics Data System (ADS)

    Venkatapathy, E.; Laub, B.; Hartman, G. J.; Arnold, J. O.; Wright, M. J.; Allen, G. A.

    2009-07-01

    The science community has continued to be interested in planetary entry probes, aerocapture, and sample return missions to improve our understanding of the Solar System. As in the case of the Galileo entry probe, such missions are critical to the understanding not only of the individual planets, but also to further knowledge regarding the formation of the Solar System. It is believed that Saturn probes to depths corresponding to 10 bars will be sufficient to provide the desired data on its atmospheric composition. An aerocapture mission would enable delivery of a satellite to provide insight into how gravitational forces cause dynamic changes in Saturn's ring structure that are akin to the evolution of protoplanetary accretion disks. Heating rates for the "shallow" Saturn probes, Saturn aerocapture, and sample Earth return missions with higher re-entry speeds (13-15 km/s) from Mars, Venus, comets, and asteroids are in the range of 1-6 KW/cm 2. New, mid-density thermal protection system (TPS) materials for such probes can be mission enabling for mass efficiency and also for use on smaller vehicles enabled by advancements in scientific instrumentation. Past consideration of new Jovian multiprobe missions has been considered problematic without the Giant Planet arcjet facility that was used to qualify carbon phenolic for the Galileo probe. This paper describes emerging TPS technologies and the proposed use of an affordable, small 5 MW arcjet that can be used for TPS development, in test gases appropriate for future planetary probe and aerocapture applications. Emerging TPS technologies of interest include new versions of the Apollo Avcoat material and a densified variant of Phenolic Impregnated Carbon Ablator (PICA). Application of these and other TPS materials and the use of other facilities for development and qualification of TPS for Saturn, Titan, and Sample Return missions of the Stardust class with entry speeds from 6.0 to 28.6 km/s are discussed.

  20. Relationship between resist outgassing and EUV witness sample contamination in NXE outgas qualification using electrons and EUV photons

    NASA Astrophysics Data System (ADS)

    Pollentier, I.; Tirumala Venkata, A.; Gronheid, R.

    2014-04-01

    EUV photoresists are considered as a potential source of optics contamination, since they introduce irradiation-induced outgassing in the EUV vacuum environment. Therefore, before these resists can be used on e.g. ASML NXE:3100 or NXE:3300, they need to be tested in dedicated equipment according to a well-defined procedure, which is based on exposing a witness sample (WS) in the vicinity of a simultaneously exposed resist as it outgasses. Different system infrastructures are used at multiple sites (e.g. NIST, CNSE, Sematech, EIDEC, and imec) and were calibrated to each other by a detailed test plan. Despite this detailed tool qualifications, a first round robin comparison of identical materials showed inconsistent outgas test results, and required further investigation by a second round robin. Since the resist exposure mode is different at the various locations (some sites are using EUV photons while others use E-gun electrons), this difference has always a point of concern for variability of test results. In this work we compare the outgas test results from EUV photon and electron exposure using the resist materials of the second round robin. Since the imec outgas tester allows both exposure methods on the resist, a within-system comparison is possible and showed limited variation between photon and electron exposure mode. Therefore the system-to-system variability amongst the different outgas test sites is expected to be related to other parameters than the electron/photon exposure mode. Initial work showed that the variability might be related to temperature, E-gun emission excursion, and/or residual outgassing scaled by different wafer areas at the different sites.

  1. Exceptionally Persistent Fireball Over the British Isles 2012 September 21, 21h55m-21h58m UT 2012 September 21, 21h55m-21h58m UT

    NASA Astrophysics Data System (ADS)

    McBeath, Alastair; Lyytinen, Esko; Langbroek, Marco; Matson, Robert D.

    2014-06-01

    Details from trajectory and orbital analyses are presented and discussed concerning an unusually long-lasting, heavily fragmenting, fireball which flew from above northern Germany across the central British Isles between 21h55m and 21h58m UT on 2012 September 21, ending over the North Atlantic Ocean. The fireball was observed for more than 2m40s and its complete visible flight may have lasted five minutes. Its approach angle was shallow, causing it to show a period with a rising trajectory within the atmosphere, before descending again to a probable splashdown point roughly 1500 km off western Ireland about eight minutes after it first became luminous. Meteorites may have fallen on land during the flight, although none were recovered. A comparison between the projected surface tracks determined independently using visual and imaging data was possible, to test the general accuracy of the visual findings. Some discussion of the associated sonics, both electrophonic and acoustic is given too, as well as identifying difficulties found during the analyses, including with some of the imaging data, and the effort involved in sifting through a final 995 individual observations of this meteor.

  2. Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes

    PubMed Central

    Brott, David A; Furlong, Stephen T; Adler, Scott H; Hainer, James W; Arani, Ramin B; Pinches, Mark; Rossing, Peter; Chaturvedi, Nish

    2015-01-01

    Background Identifying the potential for drug-induced kidney injury is essential for the successful research and development of new drugs. Newer and more sensitive preclinical drug-induced kidney injury biomarkers are now qualified for use in rat toxicology studies, but biomarkers for clinical studies are still undergoing qualification. The current studies investigated biomarkers in healthy volunteer (HV) urine samples with and without the addition of stabilizer as well as in urine from patients with normoalbuminuric diabetes mellitus (P-DM). Methods Urine samples from 20 male HV with stabilizer, 69 male HV without stabilizer, and 95 male DM without stabilizer (39 type 1 and 56 type 2) were analyzed for the following bio-markers using multiplex assays: α-1-microglobulin (A1M), β-2-microglobulin, calbindin, clus-terin, connective tissue growth factor (CTGF), creatinine, cystatin-C, glutathione S-transferase α (GSTα), kidney injury marker-1 (KIM-1), microalbumin, neutrophil gelatinase-associated lipocalin, osteopontin, Tamm–Horsfall urinary glycoprotein (THP), tissue inhibitor of metalloproteinase 1, trefoil factor 3 (TFF3), and vascular endothelial growth factor. Results CTGF and GSTα assays on nonstabilized urine were deemed nonoptimal (>50% of values below assay lower limits of quantification). “Expected values” were determined for HV with stabilizer, HV without stabilizer, and P-DM without stabilizer. There was a statistically significant difference between HV with stabilizer compared to HV without stabilizer for A1M, CTGF, GSTα, and THP. DM urine samples differed from HV (without stabilizer) for A1M CTGF, GSTα, KIM-1, microalbumin, osteopontin, and TFF3. A1M also correctly identified HV and DM with an accuracy of 89.0%. Summary These studies: 1) determined that nonstabilized urine can be used for assays under qualification; and 2) documented that A1M, CTGF, GSTα, KIM-1, microalbumin, osteopontin, and TFF3 were significantly increased in urine from

  3. Fabrication and qualification of roughness reference samples for industrial testing of surface roughness levels below 0.5 nm Sq

    NASA Astrophysics Data System (ADS)

    Faehnle, O.; Langenbach, E.; Zygalsky, F.; Frost, F.; Fechner, R.; Schindler, A.; Cumme, M.; Biskup, H.; Wünsche, C.; Rascher, R.

    2015-08-01

    Applying reactive ion beam etching (RIBE) processes at the Leibniz Institute of Surface Modification (IOM), several reference samples to be used in industry for calibrating of roughness testing equipment have been generated with the smoothest sample featuring 0.1 nm rms Sq. Subsequently these reference samples have been measured cross-site applying atomic force microscopy (AFM), white light interferometry (WLI), Nomarski1 microscopy (NM) and scatterometry (iTIRM2) determining the appropriate range of measurable rms surface roughness for each industrial measuring device.

  4. Evaporator Feed Qualification Analysis Of Tank 38H And 43H Samples: January 2010 Through April 2013

    SciTech Connect

    Martino, C. J.; Coleman, C. J.

    2013-08-21

    This report provides the results of analyses that focused on the chemical species that pertain to the sodium aluminosilicate formation potential for archived Tank 38H and 43H subsurface samples from January 2010 through April 2013. Analyses included warm acid strike preparation followed by analysis of silicon, aluminum, and sodium and water dilution preparation followed by analysis for anions. The Tank 43H and 38H supernatant liquid silicon measurements for the January 2010 through April 2013 time period exhibit a slight increasing trend. Over this time period, the silicon concentration in the Tank 43H and Tank 38H samples averaged 179 mg/L and 235 mg/L, respectively. Comparison of Tank 43H sample results from 2005 through April 2013 to the previously developed process control models indicates that the current formation of sodium aluminosilicate in the 2H system is due to the seeded direct precipitation of cancrinite and sodalite.

  5. 3-hydroxy-2(1H)-pyridinone chelating agents

    DOEpatents

    Raymond, K.N.; Xu, J.

    1997-04-29

    Disclosed is a series of improved metal chelating agents, which are highly effective upon both injection and oral administration; several of the most effective are of low toxicity. These chelating agents incorporate within their structure 1-hydroxy-2-pyridinone (1,2-HOPO) and 3-hydroxy-2-pyridinone (3,2-HOPO) moieties with a substituted carbamoyl group ortho to the hydroxy or oxo groups of the hydroxypyridinone ring. The electron-withdrawing carbamoyl group increases the acidity of the hydroxypyridinones. In the metal complexes of the chelating agents, the amide protons form very strong hydrogen bonds with its adjacent HOPO oxygen donor, making these complexes very stable at physiological conditions. The terminal N-substituents provides a certain degree of lipophilicity to the 3,2-HOPO, increasing oral activity. Also disclosed is a method of making the chelating agents and a method of producing a known compound, 3-hydroxy-1-alkyl-2(1H)pyridinone, used as a precursor to the chelating agent, safely and in large quantities. 2 figs.

  6. 3-hydroxy-2(1H)-pyridinone chelating agents

    DOEpatents

    Raymond, Kenneth N.; Xu, Jide

    1997-01-01

    Disclosed is a series of improved metal chelating agents, which are highly effective upon both injection and oral administration; several of the most effective are of low toxicity. These chelating agents incorporate within their structure 1-hydroxy-2-pyridinone (1,2-HOPO) and 3-hydroxy-2-pyridinone (3,2-HOPO) moieties with a substituted carbamoyl group ortho to the hydroxy or oxo groups of the hydroxypyridinone ring. The electron-withdrawing carbamoyl group increases the acidity of the hydroxypyridinones. In the metal complexes of said chelating agents, the amide protons form very strong hydrogen bonds with its adjacent HOPO oxygen donor, making these complexes very stable at physiological conditions. The terminal N-substituents provides a certain degree of lipophilicity to said 3,2-HOPO, increasing oral activity. Also disclosed is a method of making the chelating agents and a method of producing a known compound, 3-hydroxy-1-alkyl-2(1H)pyridinone, used as a precursor to the chelating agent, safely and in large quantities.

  7. 16 CFR 1209.34 - Qualification testing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.34 Qualification testing. (a... cellulose insulation which is subject to the standard, samples of the insulation shall be tested...

  8. 16 CFR 1209.34 - Qualification testing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.34 Qualification testing. (a... cellulose insulation which is subject to the standard, samples of the insulation shall be tested...

  9. 16 CFR 1209.34 - Qualification testing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.34 Qualification testing. (a... cellulose insulation which is subject to the standard, samples of the insulation shall be tested...

  10. 16 CFR 1209.34 - Qualification testing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INTERIM SAFETY STANDARD FOR CELLULOSE INSULATION Certification § 1209.34 Qualification testing. (a... cellulose insulation which is subject to the standard, samples of the insulation shall be tested...

  11. The Big-Five Personality Traits, Maternal Smoking during Pregnancy, and Educational Qualifications as Predictors of Tobacco Use in a Nationally Representative Sample

    PubMed Central

    Cheng, Helen; Furnham, Adrian

    2016-01-01

    Objective To investigate the associations between the Big-Five personality traits, parental social class, maternal smoking status during pregnancy, childhood cognitive ability, education and occupation, and tobacco use in a longitudinal birth cohort study. Method 17,415 babies born in Great Britain in 1958 and followed up at 11, 33, and 50 years of age. Lifelong tobacco use status (ever/never) and current tobacco use status (yes/no) at age 50 years were the outcome measures respectively. Results Logistic regression analyses showed that among the 5,840 participants with complete data, whilst maternal smoking status, educational qualifications, and all the big-5 personality traits were significant predictors of adult lifelong tobacco use; educational qualifications, own occupational levels, traits Extraversion, Conscientiousness, and Openness were significant predictors of current smoking status. In lifelong measure men tended to have a greater rate of tobacco use than women (52.1% in men and 49.2% in women). However, the sex effect on lifelong tobacco use ceased to be significant once a set of socio-economic and psychological variables in childhood and adulthood were taken into account. Conclusion Educational qualifications and the Big-Five personality traits were significantly associated with both current and lifelong tobacco use status. PMID:26731730

  12. Computer aided inspection qualification

    NASA Astrophysics Data System (ADS)

    McNab, D.; McNab, A.; Potts, A.; Toft, M.; McDonald, J.

    2002-05-01

    Inspection Qualification under the ENIQ methodology uses a Technical Justification as a key element in assuring the performance of the inspection. It combines a mixture of physical reasoning and modeling linked to limited experimental trial data from identified worst-case defects, but the qualification process is costly and time-consuming. This paper describes an investigation into providing an integrated set of intelligent software tools to aid the process of inspection qualification.

  13. Regioselectively Controlled Synthesis of N-Substituted (Trifluoromethyl)pyrimidin-2(1H)-ones.

    PubMed

    da Silva, Andreia M P W; da Silva, Fabio M; Bonacorso, Helio G; Frizzo, Clarissa P; Martins, Marcos A P; Zanatta, Nilo

    2016-05-01

    A simple and regioselectively controlled method for the preparation of both 1,4- and 1,6-regioisomers of 1-substituted 4(6)-trifluoromethyl-pyrimidin-2(1H)-ones is described. Both regioisomers were synthesized from the cyclocondensation reaction of 4-substituted 1,1,1-trifluoro-4-methoxybut-3-en-2-ones: with nonsymmetric ureas for the 1-substituted 4-(trifluoromethyl)pyrimidin-2(1H)-ones (1,4-isomer) and with nonsymmetric 1-substituted 2-methylisothiourea sulfates for the synthesis of 1-substituted 6-(trifluoromethyl)pyrimidin-2(1H)-ones (1,6-isomer). Each method furnished only the respective isomer in very good yields. The structure of the products was assigned based on the (1)H and (13)C NMR as well as 2D HMBC spectral analysis. PMID:27070191

  14. The Instructional Communicative Qualification of Parents with Students

    ERIC Educational Resources Information Center

    Ozcinar, Zehra

    2004-01-01

    This research was done to find out the present communicative qualification of parents with students. Through the research, parents of primary school V. grade students were chosen for sampling. Data have been collected with "the scale of instructional communicative qualification of parents" that its reliability and validity study have done and…

  15. Direct phosphonation of quinoxalin-2(1H)-ones under transition-metal-free conditions.

    PubMed

    Gao, Ming; Li, Yi; Xie, Lijuan; Chauvin, Remi; Cui, Xiuling

    2016-02-01

    A direct C-H bond phosphonation of quinoxalin-2(1H)-ones with H-phosphonates, H-phosphinates or H-phosphine oxides has been developed. A wide variety of heteroaryl phosphonates were obtained in up to 92% yield for 20 examples under transition-metal-free conditions. This protocol tolerates a broad scope of substrates and features practicality, high efficiency, environmental friendliness and atom economy. PMID:26779573

  16. Industry perspectives on biomarker qualification.

    PubMed

    Lavezzari, G; Womack, A W

    2016-02-01

    Biomarkers have the potential to expedite drug development, increase patient safety, and optimize clinical response. Yet few have achieved regulatory qualification. A survey was conducted to clarify industry's perspective on biomarker qualification and identify the most promising biomarkers for drug development. The results across toxicities/clinical areas highlight challenges in regulatory qualification, although early prioritization and alignment on an evidentiary standard framework are key factors in facilitating biomarker development and qualification. PMID:26378777

  17. ITOUGH2 software qualification

    SciTech Connect

    Finsterle, S.; Pruess, K.; Fraser, P.

    1996-10-01

    The purpose of this report is to provide all software baseline documents necessary for the software qualification of ITOUGH2. ITOUGH2 is a computer program providing inverse modeling capabilities for TOUGH2. TOUGH2 is a numerical simulation code for multi-dimensional coupled fluid and heat flow of multiphase, multicomponent fluid mixtures in porous and fractured media.

  18. Bioactive 2(1H)-Pyrazinones and Diketopiperazine Alkaloids from a Tunicate-Derived Actinomycete Streptomyces sp.

    PubMed

    Shaala, Lamiaa A; Youssef, Diaa T A; Badr, Jihan M; Harakeh, Steve M

    2016-01-01

    As a part of our ongoing effort to allocate marine microbial bioactive leads, a tunicate-derived actinomycete, Streptomyces sp. Did-27, was investigated. Three new 2(1H)-pyrazinones derivatives, (S)-6-(sec-butyl)-3-isopropylpyrazin-2(1H)-one (1), (S)-3-(sec-butyl)-6-isopropylpyrazin-2(1H)-one (2) and (S)-6-(sec-butyl)-3-isobutylpyrazin-2(1H)-one (3), together with the known (1H)-pyrazinones analogues deoxymutaaspergillic acid (4), 3,6-diisobutyl-2(1H)-pyrazinone (5) and 3,6-di-sec-butyl-2(1H)-pyrazinone (6), and the diketopiperazine alkaloids cyclo(6-OH-d-Pro-l-Phe) (7), bacillusamide B (8), cyclo(l-Pro-l-Leu) and cyclo(l-Pro-l-Ile) (10) were isolated from this strain. The structures of the compounds were determined by study of their one- and two-dimensional NMR spectra as well as high-resolution mass spectral determinations. Compound 4 was reported previously as a synthetic product, while compound 6 was reported as 2-hydroxy-3,6-di-sec-butylpyrazine. Herein, we report the complete NMR data for compounds 4 and 6. The compounds were evaluated for their cytotoxic activities against three cell lines. Compound 5 showed potent and selective activity against HCT-116 cell line with IC50 of 1.5 μg/mL, while 1-10 showed variable cytotoxic activities against these cancer cell lines. These results provide further understanding about the chemistry and bioactivities of the alkylated 2(1H)-pyrazinone derivatives. PMID:27563872

  19. Equivalence to the Minimum Qualifications

    ERIC Educational Resources Information Center

    Academic Senate for California Community Colleges, 2006

    2006-01-01

    In 1988 the Community College Reform Act (AB 1725) began a phase out of credentials in favor of a process for establishing minimum qualifications and the determination of equivalencies that are at least equal to the state-adopted minimum qualifications for a particular discipline. According to Education Code sections 87359 and 87360, someone…

  20. Equivalence to the Minimum Qualifications.

    ERIC Educational Resources Information Center

    California Community Colleges, Sacramento. Academic Senate.

    Assembly Bill (AB) 1725 provides for the hiring of faculty who do not meet the precise letter of the minimum qualifications, provided that the governing board of an institution determines that an applicant possesses qualifications that are at least equivalent. In order to make these determinations, each district must have and use an equivalency…

  1. Perspectives on anechoic chamber qualification

    NASA Astrophysics Data System (ADS)

    Cunefare, Kenneth A.; Biesel, Van B.

    2002-11-01

    The qualification of a new anechoic chamber requires demonstration that the chamber produces a free-field environment within some tolerance bounds and over some acceptable volume. At the most basic level, qualification requires measurement of sound levels at increasing distances from a test source, and then comparing the levels to a theoretical free-field decay. While simple in concept, the actual performance of a qualification test is problematic in implementation, with troublesome issues relevant to the nature of the sound source, test signal (broadband or pure tone), spatial resolution of measurements (e.g., measurements at discrete locations or spatially continuous), and comparison of the data to a theoretical decay. This presentation will provide a brief historical perspective on chamber qualification and review current practice. It will demonstrate the inadequacy of broadband noise and widely spaced discrete measurements for qualification purposes. It will demonstrate that pure tone signals and spatially continuous measurements provide a rigorous test of a chambers performance.

  2. A general Pd/Cu-catalyzed C-H heteroarylation of 3-bromoquinolin-2(1H)-ones.

    PubMed

    Bruneau, Alexandre; Brion, Jean-Daniel; Messaoudi, Samir; Alami, Mouad

    2014-11-14

    3-(Heteroaryl)quinolin-2(1H)-ones were synthesized in good to excellent yields using a bimetallic catalytic system through the C-H heteroarylation strategy. Starting from 3-bromoquinolin-2(1H)-ones, various azoles have been successfully used. In all cases, the reactions take place rapidly in dioxane and efficiently proceed in the presence of a bimetallic Pd(OAc)2/CuI as the catalyst, PPh3 as the ligand and LiOtBu or KOAc as the base. PMID:25237986

  3. TOUGH2 software qualification

    SciTech Connect

    Pruess, K.; Simmons, A.; Wu, Y.S.; Moridis, G.

    1996-02-01

    TOUGH2 is a numerical simulation code for multi-dimensional coupled fluid and heat flow of multiphase, multicomponent fluid mixtures in porous and fractured media. It belongs to the MULKOM ({open_quotes}MULti-KOMponent{close_quotes}) family of codes and is a more general version of the TOUGH simulator. The MULKOM family of codes was originally developed with a focus on geothermal reservoir simulation. They are suited to modeling systems which contain different fluid mixtures, with applications to flow problems arising in the context of high-level nuclear waste isolation, oil and gas recovery and storage, and groundwater resource protection. TOUGH2 is essentially a subset of MULKOM, consisting of a selection of the better tested and documented MULKOM program modules. The purpose of this package of reports is to provide all software baseline documents necessary for the software qualification of TOUGH2.

  4. Alkaline etch system qualification

    SciTech Connect

    Goldammer, S.E.; Pemberton, S.E.; Tucker, D.R.

    1997-04-01

    Based on the data from this qualification activity, the Atotech etch system, even with minimum characterization, was capable of etching production printed circuit products as good as those from the Chemcut system. Further characterization of the Atotech system will improve its etching capability. In addition to the improved etch quality expected from further characterization, the Atotech etch system has additional features that help reduce waste and provide for better consistency in the etching process. The programmable logic controller and computer will allow operators to operate the system manually or from pre-established recipes. The evidence and capabilities of the Atotech system made it as good as or better than the Chemcut system for etching WR products. The Printed Wiring Board Engineering Department recommended that the Atotech system be released for production. In December 1995, the Atotech system was formerly qualified for production.

  5. Transportation monitoring unit qualification

    NASA Technical Reports Server (NTRS)

    Cook, M.

    1990-01-01

    Transportation monitoring unit (TMU) qualification testing was performed between 3 Mar. and 14 Dec. 1989. The purpose of the testing was to qualify the TMUs to monitor and store temperature and acceleration data on redesigned solid rocket motor segments and exit cones while they are being shipped from Utah's Thiokol Corporation, Space Operations, to Kennedy Space Center. TMUs were subjected to transportation tests that concerned the structural integrity of the TMUs only, and did not involve TMU measuring capability. This testing was terminated prior to completion due to mounting plate failures, high and low temperature shutdown failures, and data collection errors. Corrective actions taken by the vendor to eliminate high temperature shutdowns were ineffective. An evaluation was performed on the TMUs to determine the TMU vibration and temperature measuring accuracy at a variety of temperatures. This test demonstrated that TMU measured shock levels are high, and that TMUs are temperature sensitive because of decreased accuracy at high and low temperatures. It was determined that modifications to the current TMU system, such that it could be qualified for use, would require a complete redesign and remanufacture. Because the cost of redesigning and remanufacturing the present TMU system exceeds the cost of procuring a new system that could be qualified without modification, it is recommended that an alternate transportation monitoring system be qualified.

  6. 14 CFR 60.29 - Other losses of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Other losses of qualification and procedures for restoration of qualification. 60.29 Section 60.29 Aeronautics and Space FEDERAL AVIATION... CONTINUING QUALIFICATION AND USE § 60.29 Other losses of qualification and procedures for restoration...

  7. 14 CFR 60.29 - Other losses of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Other losses of qualification and procedures for restoration of qualification. 60.29 Section 60.29 Aeronautics and Space FEDERAL AVIATION... CONTINUING QUALIFICATION AND USE § 60.29 Other losses of qualification and procedures for restoration...

  8. 14 CFR 60.27 - Automatic loss of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Automatic loss of qualification and procedures for restoration of qualification. 60.27 Section 60.27 Aeronautics and Space FEDERAL AVIATION... CONTINUING QUALIFICATION AND USE § 60.27 Automatic loss of qualification and procedures for restoration...

  9. 14 CFR 60.29 - Other losses of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Other losses of qualification and procedures for restoration of qualification. 60.29 Section 60.29 Aeronautics and Space FEDERAL AVIATION... CONTINUING QUALIFICATION AND USE § 60.29 Other losses of qualification and procedures for restoration...

  10. 14 CFR 60.27 - Automatic loss of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Automatic loss of qualification and procedures for restoration of qualification. 60.27 Section 60.27 Aeronautics and Space FEDERAL AVIATION... CONTINUING QUALIFICATION AND USE § 60.27 Automatic loss of qualification and procedures for restoration...

  11. 14 CFR 60.27 - Automatic loss of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Automatic loss of qualification and procedures for restoration of qualification. 60.27 Section 60.27 Aeronautics and Space FEDERAL AVIATION... CONTINUING QUALIFICATION AND USE § 60.27 Automatic loss of qualification and procedures for restoration...

  12. Advanced qualification techniques

    SciTech Connect

    Winokur, P.S; Shaneyfelt, M.R.; Meisenheimer, T.L.; Fleetwood, D.M.

    1993-12-01

    This paper demonstrates use of the Qualified Manufacturers List (QML) methodology to qualify commercial and military microelectronics for use in space applications. QML ``builds in`` the hardness of product through statistical process control (SPC) of technology parameters relevant to the radiation response, test structure to integrated circuit (IC) correlations, and techniques for extrapolating laboratory test results to low-dose-rate space scenarios. Each of these elements is demonstrated and shown to be a cost-effective alternative to expensive end-of-line IC testing. Several examples of test structured-IC correlations are provided and recent work on complications arising from transistor scaling and geometry is discussed. The use of a 10-keV x-ray wafer-level test system to support SPC and establish ``process capability`` is illustrated and a comparison of 10-keV x-ray and Co{sup 60} gamma irradiations is provided for a wide range of CMOS technologies. The x-ray tester is shown to be cost-effective and its use in lot acceptance/qualification is recommended. Finally, a comparison is provided between MIL-STD-883D, Test Method 1019.4, which governs the testing of packaged semiconductor microcircuits in the DoD, and ESA/SSC Basic Specification No. 22900, Europe`s Total Dose Steady-State Irradiation Test Method. Test Method 1019.4 focuses on conservative estimates of MOS hardness for space and tactical applications, while Basic Specification 22900 focuses on improved simulation of low-dose-rate space environments.

  13. Advanced qualification techniques

    NASA Astrophysics Data System (ADS)

    Winokur, P. S.; Shaneyfelt, M. R.; Meisenheimer, T. L.; Fleetwood, D. M.

    This paper demonstrates use of the Qualified Manufacturers List (QML) methodology to qualify commercial and military microelectronics for use in space applications. QML 'builds in' the hardness of product through statistical process control (SPC) of technology parameters relevant to the radiation response, test structure to integrated circuit (IC) correlations, and techniques for extrapolating laboratory test results to low-dose-rate space scenarios. Each of these elements is demonstrated and shown to be a cost-effective alternative to expensive end-of-line IC testing. Several examples of test structured-IC correlations are provided and recent work on complications arising from transistor scaling and geometry is discussed. The use of a 10-keV x-ray wafer-level test system to support SPC and establish 'process capability' is illustrated and a comparison of 10-keV x-ray and Co-60 gamma irradiations is provided for a wide range of CMOS technologies. The x-ray tester is shown to be cost-effective and its use in lot acceptance/qualification is recommended. Finally, a comparison is provided between MIL-STD-883D, Test Method 1019.4, which governs the testing of packaged semiconductor microcircuits in the DoD, and ESA/SSC Basic Specification No. 22900, Europe's Total Dose Steady-State Irradiation Test Method. Test Method 1019.4 focuses on conservative estimates of MOS hardness for space and tactical applications, while Basic Specification 22900 focuses on improved simulation of low-dose-rate space environments.

  14. Advanced qualification techniques

    SciTech Connect

    Winokur, P.S.; Shaneyfelt, M.R.; Meisenheimer, T.L.; Fleetwood, D.M. )

    1994-06-01

    This paper demonstrates use of the Qualified Manufacturers List (QML) methodology to qualify commercial and military microelectronics for use in space applications. QML ''builds in'' the hardness of product through statistical process control (SPC) of technology parameters relevant to the radiation response, test structure to integrated circuit (IC) correlations, and techniques for extrapolating laboratory test results to low-dose-rate space scenarios. Each of these elements is demonstrated and shown to be a cost-effective alternative to expensive end-of-line IC testing. Several examples of test structure-to-IC correlations are provided and recent work on complications arising from transistor scaling and geometry is discussed. The use of a 10-keV x-ray wafer-level test system to support SPC and establish ''process capability'' is illustrated and a comparison of 10-kev x-ray wafer-level test system to support SPC and establish ''process capability'' is illustrated and a comparison of 10-keV x-ray and Co[sup 60] gamma irradiations is provided for a wide range of CMOS technologies. The x-ray tester is shown to be cost-effective and its use in lot acceptance/qualification is recommended. Finally, a comparison is provided between MIL-STD-883, Test Method 1019.4, which governs the testing of packaged semiconductor microcircuits in the DoD, and ESA/SCC Basic Specification No. 22900, Europe's Total Dose Steady-State Irradiation Test Method. Test Method 1019.4 focuses on conservative estimates of MOS hardness for space and tactical applications, while Basic Specification 22900 focuses on improved simulation of low-dose-rate space environments.

  15. Advanced qualification techniques

    NASA Astrophysics Data System (ADS)

    Winokur, P. S.; Shaneyfelt, M. R.; Meisenheimer, T. L.; Fleetwood, D. M.

    1994-06-01

    This paper demonstrates use of the Qualified Manufacturers List (QML) methodology to qualify commercial and military microelectronics for use in space applications. QML 'builds in' the hardness of product through statistical process control (SPC) of technology parameters relevant to the radiation response, test structure to integrated circuit (IC) correlations, and techniques for extrapolating laboratory test results to low-dose-rate space scenarios. Each of these elements is demonstrated and shown to be a cost-effective alternative to expensive end-of-line IC testing. Several examples of test structure-to-IC correlations are provided and recent work on complications arising from transistor scaling and geometry is discussed. The use of a 10-keV x-ray wafer-level test system to support SPC and establish 'process capability' is illustrated and a comparison of 10-keV x-ray and Co-60 gamma irradiations is provided for a wide range of CMOS technologies. The x-ray tester is shown to be cost-effective and its use in lot acceptance/qualification is recommended. Finally, a comparison is provided between MIL-STD-883, Test Method 1019.4, which governs the testing of packaged semiconductor microcircuits in the DoD, and ESA/SCC Basic Specification No. 22900, Europe's Total Dose Steady-State Irradiation Test Method. Test Method 1019.4 focuses on conservative estimates of MOS hardness for space and tactical applications, while Basic Specification 22900 focuses on improved simulation of low-dose-rate space environments.

  16. Synthesis and structure of interaction products of quinoline-2(1H)-thione with molecular iodine.

    PubMed

    Chernov'yants, Margarita S; Starikova, Zoya A; Kolesnikova, Tatiana S; Karginova, Anastasia O; Lyanguzov, Nikolay V

    2015-03-15

    The behavior of quinoline-2(1H)-thione, which is a potential antithyroid drug toward molecular iodine, was investigated. The ability of quinoline-2(1H)-thione to form the outer-sphere charge-transfer complex C9H7NS·I2 with iodine molecular in dilute chloroform solution has been studied by UV-vis spectroscopy (lgβ=3.85). The crystal structure of the new salt 2-(quinoline-2-yldisulfanyl)quinolinium triiodide - product of irreversible oxidation of quinoline-2(1H)-thione was determined by X-ray diffraction. The 2-(quinoline-2-yldisulfanyl)quinolinium cations form dimers through π-π-stacking interaction between quinoline rings. Strong intramolecular interactions are observed between iodine - sulfur atoms and iodine - hydrogen atoms with shortened contacts (less of sum of van der Waals contacts). It is noteworthy that two perfectly centrosymmetrical anions I3(-) form a very short contact I(3)⋯I(3') 3.7550(5) so we can state the formation of the dianion I(6)(2-). Therefore the formation and topology of polyiodide species depend on the characteristics, such as shape, size and charge, etc., of the counter cation, 2-(quinoline-2-yldisulfanyl)quinolinium, which is considered as templating agent. PMID:25579655

  17. 42 CFR 61.34 - Qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Qualifications. 61.34 Section 61.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Service Fellowships § 61.34 Qualifications. Scholastic and other qualifications shall...

  18. 42 CFR 61.34 - Qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Qualifications. 61.34 Section 61.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Service Fellowships § 61.34 Qualifications. Scholastic and other qualifications shall...

  19. 42 CFR 61.34 - Qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Qualifications. 61.34 Section 61.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Service Fellowships § 61.34 Qualifications. Scholastic and other qualifications shall...

  20. 42 CFR 61.34 - Qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Qualifications. 61.34 Section 61.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Service Fellowships § 61.34 Qualifications. Scholastic and other qualifications shall...

  1. 42 CFR 61.34 - Qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Qualifications. 61.34 Section 61.34 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Service Fellowships § 61.34 Qualifications. Scholastic and other qualifications shall...

  2. 29 CFR 32.14 - Job qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Job qualifications. 32.14 Section 32.14 Labor Office of the... FINANCIAL ASSISTANCE Employment Practices and Employment Related Training Participation § 32.14 Job... appropriateness of all job qualifications to ensure that to the extent job qualifications tend to...

  3. 29 CFR 32.14 - Job qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Job qualifications. 32.14 Section 32.14 Labor Office of the... FINANCIAL ASSISTANCE Employment Practices and Employment Related Training Participation § 32.14 Job... appropriateness of all job qualifications to ensure that to the extent job qualifications tend to...

  4. 29 CFR 32.14 - Job qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Job qualifications. 32.14 Section 32.14 Labor Office of the... FINANCIAL ASSISTANCE Employment Practices and Employment Related Training Participation § 32.14 Job... appropriateness of all job qualifications to ensure that to the extent job qualifications tend to...

  5. 29 CFR 32.14 - Job qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Job qualifications. 32.14 Section 32.14 Labor Office of the... FINANCIAL ASSISTANCE Employment Practices and Employment Related Training Participation § 32.14 Job... appropriateness of all job qualifications to ensure that to the extent job qualifications tend to...

  6. 29 CFR 32.14 - Job qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 1 2011-07-01 2011-07-01 false Job qualifications. 32.14 Section 32.14 Labor Office of the... FINANCIAL ASSISTANCE Employment Practices and Employment Related Training Participation § 32.14 Job... appropriateness of all job qualifications to ensure that to the extent job qualifications tend to...

  7. 12 CFR 217.121 - Qualification process.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 2 2014-01-01 2014-01-01 false Qualification process. 217.121 Section 217.121... Measurement Approaches Qualification § 217.121 Qualification process. (a) Timing. (1) A Board-regulated... institution also must maintain a comprehensive and sound planning and governance process to oversee...

  8. Social Partnership in Accrediting Lithuanian VET Qualifications

    ERIC Educational Resources Information Center

    Tutlys, Vidmantas; Kaminskiene, Lina

    2008-01-01

    This article examines social partnership in accrediting qualifications in Lithuania. It defines the factors influencing social partnership and surveys future development perspectives, referring to the creation and implementation of the national qualifications system in Lithuania. Social partnership in qualifications accreditation is regarded as a…

  9. 10 CFR 603.510 - Recipient qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Recipient qualifications. 603.510 Section 603.510 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Recipient Qualification § 603.510 Recipient qualifications. Prior to award of a TIA,...

  10. 14 CFR 121.913 - Qualification curriculum.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Qualification curriculum. 121.913 Section 121.913 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED... Qualification curriculum. Each qualification curriculum must contain training, evaluation, and...

  11. 5 CFR 319.301 - Qualifications standards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Qualifications standards. 319.301 Section 319.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT IN SENIOR-LEVEL AND SCIENTIFIC AND PROFESSIONAL POSITIONS Qualifications Requirements § 319.301 Qualifications standards. (a) General. Agency...

  12. 5 CFR 319.302 - Individual qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 5 Administrative Personnel 1 2014-01-01 2014-01-01 false Individual qualifications. 319.302 Section 319.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT IN SENIOR-LEVEL AND SCIENTIFIC AND PROFESSIONAL POSITIONS Qualifications Requirements § 319.302 Individual qualifications. Agency heads...

  13. Environmental Data Recorder (EDR) qualification

    NASA Technical Reports Server (NTRS)

    Danforth, Richard A.

    1991-01-01

    Qualification testing of the environmental data recorder (EDR) was successfully completed. The purpose of this test was to qualify the EDR so that it could monitor segments shipped via railcar from Utah to Kennedy Space Center (KSC). The tests consisted of a transportation and a functional test. The transportation test verified EDR operation in its intended environment. The functional test verified EDR accuracy. Data from the functional test showed that the EDR accuracies complied with requirements. Since the EDR meets or exceeds all of its test objectives, it was successfully qualified. It is recommended that the EDR replace the transportation monitoring unit (TMU). A description of the qualification procedure is presented.

  14. Qualifications for a Changing World.

    ERIC Educational Resources Information Center

    Vocational Training, 1991

    1991-01-01

    This theme issue focuses on skills and qualifications in future world markets in general and in the Single Market within the European Community (EC). The first two articles are "Anthropocentric Production Systems: Advanced Manufacturing is Based on Skilled People" (Werner Wobbe) and "New Skills or a New Concept of 'the Job'"? (Enrique Retuerto de…

  15. SIP qualification and PRA approaches

    NASA Technical Reports Server (NTRS)

    Ghaffarian, R.; Goetz, M.

    2002-01-01

    System in a package (SIP) development is a response to an increasing demand for integration of different functions into one unit to reduce size and cost and improve functionality. Qualification of the newly developed multifunctional electronics are becoming complex at the package level and even more at the second and system levels.

  16. Global National Qualifications Framework Inventory

    ERIC Educational Resources Information Center

    Bjornavold, Jens; Pevec-Grm, Slava; Graham, Michael; Deij, Arjen; Singh, Madhu; Charkoun, Borhène; Agrawal, Shivani

    2013-01-01

    This publication is a global, country-by-country, inventory of National Qualifications Frameworks (NQFs). It is a copublication, prepared by two EU agencies, the European Training Foundation (ETF) and the Centre for the Development of Vocational Training (Cedefop); and UNESCO's Institute for Lifelong Learning (UIL) and the Section for TVET at…

  17. Infrared Assisted Production of 3,4-Dihydro-2(1H)-pyridones in Solvent-Free Conditions

    PubMed Central

    Noguez, M. Olivia; Marcelino, Vanessa; Rodríguez, Hortensia; Martín, Osnieski; Martínez, Joel O.; Arroyo, Gabriel A.; Pérez, Francisco J.; Suárez, Margarita; Miranda, René

    2011-01-01

    A green approach for the synthesis of a set of ten 4-aryl substituted-5-alcoxy carbonyl-6-methyl-3,4-dihydro-2(1H)-pyridones using Meldrum’s acid has been devised, the absence of solvent and the activation with infrared irradiation in addition to a multicomponent protocol are the main reaction conditions. The transformations proceeded with moderated yields (50–75%) with a reasonable reaction rate (3 h). It is worth noting that two novel molecules of the new class of the bis-3,4-dihydropyridones were also obtained. In addition, a comparison without the use of infrared irradiation was performed. PMID:21731463

  18. Synthesis of 5-carboxy-6-methyl-3,4-dihydro-2(1H)-pyridone derivatives and their electrochemical oxidation to 2-pyridones

    NASA Astrophysics Data System (ADS)

    Smits, Rufus; Turovska, Baiba; Belyakov, Sergey; Plotniece, Aiva; Duburs, Gunars

    2016-04-01

    A series of variously substituted 5-carboxy-6-methyl-3,4-dihydro-2(1H)-pyridone derivatives were synthesized and their oxidation potentials determined by cyclic voltammetry. The resulting 2-pyridone structure and a tricyclic heterocycle which was formed during an attempted synthesis of 4-(2-hydroxyphenyl) substituted 3,4-dihydro-2(1H)-pyridone were confirmed by single crystal X-ray crystallography.

  19. Aeroacoustic qualification of HERMES shingles

    NASA Astrophysics Data System (ADS)

    Petiau, C.; Paret, A.

    1994-09-01

    General problems of aeroacoustic analysis are presented, taking as an example shingle studies of the HERMES space shuttle. Analysis of shingle behavior meets this problem in a particularly difficult way (very hard environment, specific difficulties due to design of shingles). Available analysis tools include: (1) calculation means, which are mainly those of aeroelasticity, and (2) ground test means (wind tunnel, progressive wave tubes, shaker,...). None of these means can alone satisfy the needs of structural dimensioning and qualification; in particular the calculation of turbulent sources is not possible today, and they are very difficult to simulate with ground testing of actual structural parts. In spite of these difficulties, and referring to the preliminary tests and calculations of HERMES shingles, a rational strategy is proposed for aeroacoustic dimensioning and qualification of structural parts. This leads to a succession of tests, the conditions of which are determined by calculations, calculation models being themselves validated by comparison with test results.

  20. Hanford Tank Waste Treatment and Immobilization Plant (WTP) Waste Feed Qualification Program Development Approach - 13114

    SciTech Connect

    Markillie, Jeffrey R.; Arakali, Aruna V.; Benson, Peter A.; Halverson, Thomas G.; Adamson, Duane J.; Herman, Connie C.; Peeler, David K.

    2013-07-01

    The Hanford Tank Waste Treatment and Immobilization Plant (WTP) is a nuclear waste treatment facility being designed and constructed for the U.S. Department of Energy by Bechtel National, Inc. and subcontractor URS Corporation (under contract DE-AC27-01RV14136 [1]) to process and vitrify radioactive waste that is currently stored in underground tanks at the Hanford Site. A wide range of planning is in progress to prepare for safe start-up, commissioning, and operation. The waste feed qualification program is being developed to protect the WTP design, safety basis, and technical basis by assuring acceptance requirements can be met before the transfer of waste. The WTP Project has partnered with Savannah River National Laboratory to develop the waste feed qualification program. The results of waste feed qualification activities will be implemented using a batch processing methodology, and will establish an acceptable range of operator controllable parameters needed to treat the staged waste. Waste feed qualification program development is being implemented in three separate phases. Phase 1 required identification of analytical methods and gaps. This activity has been completed, and provides the foundation for a technically defensible approach for waste feed qualification. Phase 2 of the program development is in progress. The activities in this phase include the closure of analytical methodology gaps identified during Phase 1, design and fabrication of laboratory-scale test apparatus, and determination of the waste feed qualification sample volume. Phase 3 will demonstrate waste feed qualification testing in support of Cold Commissioning. (authors)

  1. Qualification tests and facilities for the ITER superconductors

    NASA Astrophysics Data System (ADS)

    Bruzzone, P.; Wesche, R.; Stepanov, B.; Cau, F.; Bagnasco, M.; Calvi, M.; Herzog, R.; Vogel, M.

    2009-06-01

    All the ITER superconductors are tested as short length samples in the SULTAN test facility at CRPP. Twenty-four TF conductor samples with small layout variations were tested since February 2007 with the aim of verifying the design and qualification of the manufacturers. The sample assembly and the measurement techniques at CRPP are discussed. Starting in 2010, another test facility for ITER conductors, named EDIPO, will be operating at CRPP to share with SULTAN the load of the samples for the acceptance tests during the construction of ITER.

  2. Test chips and ASIC qualification

    NASA Technical Reports Server (NTRS)

    Buehler, M. G.; Blaes, B. R.; Lin, Y.-S.; Zamani, N.; Lieneweg, U.

    1991-01-01

    A test chip set being developed to aid in the qualification of spaceborne Application Specific Integrated Circuits (ASICs) is described. The chip set consists of a process monitor for process parameter verification, a fault chip for yield analysis, a reliability chip for ASIC failure rate analysis, and total ionizing dose and single event upset chips for radiation effect analysis. The test structures contained in these chips are discussed along with representative test results.

  3. AGR-1 Data Qualification Report

    SciTech Connect

    Michael Abbott

    2010-03-01

    ABSTRACT Projects for the very high temperature reactor (VHTR) Technology Development Office (TDO) program provide data in support of Nuclear Regulatory Commission licensing of the VHTR. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high temperature and high fluence environments. The VHTR program has established the NGNP Data Management and Analysis System (NDMAS) to ensure that VHTR data are (1) qualified for use, (2) stored in a readily accessible electronic form, and (3) analyzed to extract useful results. This document focuses on the first NDMAS objective. It describes the data streams associated with the first Advanced Gas Reactor experiment (AGR-1), the processing of these data within NDMAS, and reports the qualification status of the data. Data qualification activities within NDMAS for specific types of data are determined by the data qualification category assigned by the data generator. They include: (1) capture testing, to confirm that the data stored within NDMAS are identical to the raw data supplied, (2) accuracy testing, to confirm that the data are an accurate representation of the system or object being measured, and (3) documentation that the data were collected under an NQA-1 or equivalent quality assurance program. The NDMAS database processing and qualification status of the following five data streams is reported in this document: 1. Fuel fabrication data. All data have been processed into the NDMAS database and qualified (1,819 records). 2. Fuel irradiation data. Data from all 13 AGR-1 reactor cycles have been processed into the NDMAS database and tested. Of these, 85% have been qualified and 15% have failed NDMAS accuracy testing. 3. FPMS data. Reprocessed (January 2010) data from all 13 AGR-1 reactor cycles have been processed into the database and capture tested. Final qualification of these data will be recorded after QA approval of an Engineering Calculations and Analysis Report

  4. Australian Qualifications Framework Lower-Level Qualifications: Pathways to Where for Young People?

    ERIC Educational Resources Information Center

    Stanwick, John

    2005-01-01

    This study investigates where certificate I and II qualifications lead young people aged 15-24 years in terms of employment and further study. A prime motivation for young people undertaking these qualifications is to facilitate transition into the labour market. These qualifications are aimed at developing basic vocational skills or preparatory…

  5. Expedition 31 Qualification Training Simulation Runs

    NASA Video Gallery

    Expedition 31 Flight Engineers Gennady Padalka, Sergei Revin and Joe Acaba, along with backup crew members Kevin Ford, Oleg Novitskiy and Evgeny Tarelkin, complete qualification training simulation...

  6. Novel 1,6-naphthyridin-2(1H)-ones as potential anticancer agents targeting Hsp90.

    PubMed

    Montoir, David; Barillé-Nion, Sophie; Tonnerre, Alain; Juin, Philippe; Duflos, Muriel; Bazin, Marc-Antoine

    2016-08-25

    Hsp90 is an ATP-dependent chaperone known to be overexpressed in many cancers. This way, Hsp90 is an important target for drug discovery. Novobiocin, an aminocoumarin antibiotic, was reported to inhibit Hsp90 targeting C-terminal domain, and showed anti-proliferative properties, leading to the development of new and more active compounds. Consequently, a new set of novobiocin analogs derived from 1,6-naphthyridin-2(1H)-one scaffold was designed, synthesized and evaluated against two breast cancer cell lines. Subsequently, cell cycle progression and apoptosis were conducted on best candidates, finally Western Blot analysis was performed to measure their ability to induce degradation of Hsp90 client proteins. PMID:27153346

  7. Heteryladamantanes. Communication 5. Synthesis of 6-(1-adamantyl)-3-cyanopyridin-2(1H)-selenone and related selenophenopyridines

    SciTech Connect

    Apenova, E.E.; Sharanin, Yu.A.; Zolotarev, B.M.; Litvinov, V.P.

    1986-08-20

    Reaction of the sodium salt of 3-(1-adamantyl)-1-hydroxyprop-1-en-3-one with cyanoselenoacetamide led to the first synthesis of 6-(1-adamantyl)-3-cyanopyridine-2-(1H)-selenone. 2-Seleno substituted 6-(1-adamantyl)-3-cyanopyridines have been obtained by alkylation of pyridineselenone with RCH/sub 2/HAl. Cyclization in the presence of base gives 2-substituted 6-(1-adamantyl)-3-aminoselenopheno(2,3-b)pyridines. Under electron impact conditions 2-mercapto and 2-seleno substituted 6-(1-adamantyl)-3-cyanopyridines undergo cyclization to the corresponding substituted thieno- and selenophenopyridines. The sulfur-containing compounds do not show an ion peak corresponding to separation of the adamantyl and pyridyl rings, whereas such a process does occur in the case of the selenium analogs.

  8. Instructor Qualifications for Transferable Courses [BCCAT Position Statement

    ERIC Educational Resources Information Center

    British Columbia Council on Admissions and Transfer, 2006

    2006-01-01

    This document represents BCCAT's position on instructor qualifications within the BC Transfer System. These concern: (1) BC Transfer System Instructor Qualification Standards; and (2) Establishing and Monitoring Expectations.

  9. Qualification testing of photovoltaic concentrators

    NASA Astrophysics Data System (ADS)

    Richards, E. H.; Barlow, R. S.

    Sandia has developed a revised set of specifications for qualification testing of passively-cooled photovoltaic concentrator modules. The purpose of the tests is to screen new concentrator designs and new production runs for susceptibility to known failure mechanisms; concentrator hardware must be qualified prior to array-level installation at Sandia's Photovoltaic Advanced System Test Facility (PASTF). Tests for cell assemblies and receiver sections, as well as for complete modules, are specified. They include ultraviolet radiation testing of materials, characterization of electrical performance checks to assure safety and structural integrity of modules, and accelerated environmental aging or cycling.

  10. Bhutan's First Library Qualification, Background and Development

    ERIC Educational Resources Information Center

    Ransom, Sylvia

    2011-01-01

    During a six month contract with the Royal University of Bhutan, the author was required to develop the initial stages of a first library qualification to be offered in Bhutan. Questions raised by this project included: is a first qualification in librarianship needed in Bhutan? What are the potential student numbers in such a programme? What…

  11. Implementing a National Qualifications Framework in Lithuania

    ERIC Educational Resources Information Center

    Tutlys, Vidmantas; Spudyte, Irma

    2011-01-01

    The design of the national qualifications framework (NQF) in Lithuania started in 2006. The NQF was officially approved by the government decree in May 2010. This article explores the influence of the processes of institutional change on the reform of the national system of qualifications in Lithuania through the implementation of the NQF, looking…

  12. 42 CFR 61.5 - Qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Qualifications. 61.5 Section 61.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.5 Qualifications. In order to qualify for a regular fellowship,...

  13. 42 CFR 61.5 - Qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 1 2013-10-01 2013-10-01 false Qualifications. 61.5 Section 61.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.5 Qualifications. In order to qualify for a regular fellowship,...

  14. 42 CFR 61.5 - Qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 1 2012-10-01 2012-10-01 false Qualifications. 61.5 Section 61.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.5 Qualifications. In order to qualify for a regular fellowship,...

  15. 42 CFR 61.5 - Qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 1 2014-10-01 2014-10-01 false Qualifications. 61.5 Section 61.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.5 Qualifications. In order to qualify for a regular fellowship,...

  16. 42 CFR 61.5 - Qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 1 2011-10-01 2011-10-01 false Qualifications. 61.5 Section 61.5 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES FELLOWSHIPS, INTERNSHIPS, TRAINING FELLOWSHIPS Regular Fellowships § 61.5 Qualifications. In order to qualify for a regular fellowship,...

  17. The European Qualifications Framework: A Technical Critique

    ERIC Educational Resources Information Center

    Lester, Stan

    2015-01-01

    The European Qualifications Framework (EQF) was introduced in 2008 as a "meta-framework" or common reference point for national qualifications frameworks in Europe, a function for which, with some caveats, it has been pragmatically successful. It has also been used with variable success to support the development or referencing of…

  18. The "Home International" Comparisons in Vocational Qualifications.

    ERIC Educational Resources Information Center

    Canning, Roy; Cloonan, Martin

    2002-01-01

    A study compared the attainment of national vocational qualifications (NVQs) in Scotland and other U.K. regions. Data from the Labour Force Survey and case studies indicate that Scotland underperforms England in the attainment of NVQs, suggesting improved performance in the achievement of academic and traditional vocational qualifications in…

  19. 48 CFR 253.209 - Contractor qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 3 2011-10-01 2011-10-01 false Contractor qualifications. 253.209 Section 253.209 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.209 Contractor qualifications....

  20. 48 CFR 253.209 - Contractor qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 3 2013-10-01 2013-10-01 false Contractor qualifications. 253.209 Section 253.209 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.209 Contractor qualifications....

  1. 48 CFR 253.209 - Contractor qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 3 2014-10-01 2014-10-01 false Contractor qualifications. 253.209 Section 253.209 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.209 Contractor qualifications....

  2. 48 CFR 253.209 - Contractor qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 3 2012-10-01 2012-10-01 false Contractor qualifications. 253.209 Section 253.209 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE CLAUSES AND FORMS FORMS Prescription of Forms 253.209 Contractor qualifications....

  3. 47 CFR 13.213 - COLEM qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false COLEM qualifications. 13.213 Section 13.213 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMERCIAL RADIO OPERATORS Examination System § 13.213 COLEM qualifications. No entity may serve as a COLEM unless it has entered into a written agreement with the FCC. In order to be...

  4. 5 CFR 330.709 - Qualification reviews.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Qualification reviews. 330.709 Section... § 330.709 Qualification reviews. Agencies will ensure that a documented, independent second review is... advised in writing of the results of the second review....

  5. 5 CFR 330.609 - Qualification reviews.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Qualification reviews. 330.609 Section... Displaced Employees § 330.609 Qualification reviews. Agencies will ensure that a documented, independent second review is conducted whenever an otherwise eligible employee is determined to be not...

  6. 16 CFR 1210.14 - Qualification testing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Qualification testing. 1210.14 Section 1210.14 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.14 Qualification testing....

  7. 16 CFR 1210.14 - Qualification testing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Qualification testing. 1210.14 Section 1210.14 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.14 Qualification testing....

  8. 16 CFR 1210.14 - Qualification testing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Qualification testing. 1210.14 Section 1210.14 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR CIGARETTE LIGHTERS Certification Requirements § 1210.14 Qualification testing....

  9. 76 FR 38326 - Qualification Requirements (General)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-30

    ...; ] OFFICE OF PERSONNEL MANAGEMENT 5 CFR Part 338 RIN 3206-AL15 Qualification Requirements (General) AGENCY... Management (OPM) is proposing to revise the regulations governing qualification requirements for appointment... update and clarify information regarding citizenship and age requirements, add new information...

  10. 16 CFR 1204.15 - Qualification testing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false Qualification testing. 1204.15 Section 1204.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR OMNIDIRECTIONAL CITIZENS BAND BASE STATION ANTENNAS Certification § 1204.15 Qualification testing. (a) Testing. Before...

  11. Key Qualifications in Work and Education.

    ERIC Educational Resources Information Center

    Nijhof, Wim J., Ed.; Streumer, Jan N., Ed.

    This book contains the following chapters: "The Demarcation Issue: Introduction" (Wim J. Nijhof, Jan N. Streumer); "Qualifying for the Future" (Wim J. Nijhof); "The Many Meanings of Occupational Competence and Qualification" (Per-Erik Ellstroem); "Qualification and Labour Markets: Institutionalisation and Individualisation" (Ben Hoevels); "The…

  12. 32 CFR 171.4 - Qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 1 2012-07-01 2012-07-01 false Qualifications. 171.4 Section 171.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING IMPLEMENTATION OF WILDFIRE SUPPRESSION AIRCRAFT TRANSFER ACT OF 1996 § 171.4 Qualifications. The Secretary of...

  13. 32 CFR 171.4 - Qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Qualifications. 171.4 Section 171.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING IMPLEMENTATION OF WILDFIRE SUPPRESSION AIRCRAFT TRANSFER ACT OF 1996 § 171.4 Qualifications. The Secretary of...

  14. 32 CFR 171.4 - Qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 1 2013-07-01 2013-07-01 false Qualifications. 171.4 Section 171.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING IMPLEMENTATION OF WILDFIRE SUPPRESSION AIRCRAFT TRANSFER ACT OF 1996 § 171.4 Qualifications. The Secretary of...

  15. 32 CFR 171.4 - Qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Qualifications. 171.4 Section 171.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING IMPLEMENTATION OF WILDFIRE SUPPRESSION AIRCRAFT TRANSFER ACT OF 1996 § 171.4 Qualifications. The Secretary of...

  16. 32 CFR 171.4 - Qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 1 2014-07-01 2014-07-01 false Qualifications. 171.4 Section 171.4 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE DEFENSE CONTRACTING IMPLEMENTATION OF WILDFIRE SUPPRESSION AIRCRAFT TRANSFER ACT OF 1996 § 171.4 Qualifications. The Secretary of...

  17. Immigrant Qualifications: Recognition and Relative Wage Outcomes.

    ERIC Educational Resources Information Center

    Chapman, Bruce J.; Iredale, Robyn R.

    1993-01-01

    Uses a dataset compiled by the Australian government to examine the qualifications of ostensibly skilled immigrants. Around 39% of immigrants have chosen to subject their qualifications to local assessment, and about 42% of these have been recognized as equivalent to Australian counterparts. Wage considerations are discussed. (SLD)

  18. 7 CFR 400.170 - General qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false General qualifications. 400.170 Section 400.170..., DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE REGULATIONS Reinsurance Agreement-Standards for Approval; Regulations for the 1997 and Subsequent Reinsurance Years § 400.170 General qualifications. To...

  19. 7 CFR 400.170 - General qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 6 2011-01-01 2011-01-01 false General qualifications. 400.170 Section 400.170..., DEPARTMENT OF AGRICULTURE GENERAL ADMINISTRATIVE REGULATIONS Reinsurance Agreement-Standards for Approval; Regulations for the 1997 and Subsequent Reinsurance Years § 400.170 General qualifications. To...

  20. Qualifications Frameworks in Africa: A Critical Reflection

    ERIC Educational Resources Information Center

    Higgs, P.; Keevy, J.

    2009-01-01

    Today there is an accelerating trend towards qualifications frameworks as an instrument to develop, classify and recognise formal learning across the African continent, as is also the case across most of Europe, Australasia and the Asia-Pacific region. As more and more countries and regions across the world develop qualifications frameworks to…

  1. 27 CFR 19.643 - Qualification requirements.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ..., DEPARTMENT OF THE TREASURY ALCOHOL DISTILLED SPIRITS PLANTS Production of Vinegar by the Vaporizing Process Qualification, Construction, and Equipment Requirements for Vinegar Plants § 19.643 Qualification requirements. Before beginning the business of manufacturing vinegar by the vaporizing process, a person must...

  2. 27 CFR 19.643 - Qualification requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Production of Vinegar by the Vaporizing Process Qualification, Construction, and Equipment Requirements for Vinegar Plants § 19.643 Qualification requirements. Before beginning the business of manufacturing vinegar by the vaporizing process, a person must...

  3. 27 CFR 19.643 - Qualification requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ..., DEPARTMENT OF THE TREASURY ALCOHOL DISTILLED SPIRITS PLANTS Production of Vinegar by the Vaporizing Process Qualification, Construction, and Equipment Requirements for Vinegar Plants § 19.643 Qualification requirements. Before beginning the business of manufacturing vinegar by the vaporizing process, a person must...

  4. 27 CFR 19.643 - Qualification requirements.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ..., DEPARTMENT OF THE TREASURY LIQUORS DISTILLED SPIRITS PLANTS Production of Vinegar by the Vaporizing Process Qualification, Construction, and Equipment Requirements for Vinegar Plants § 19.643 Qualification requirements. Before beginning the business of manufacturing vinegar by the vaporizing process, a person must...

  5. 42 CFR 410.134 - Provider qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 2 2012-10-01 2012-10-01 false Provider qualifications. 410.134 Section 410.134 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider qualifications. For Medicare Part B coverage...

  6. Qualification and the Internal European Market.

    ERIC Educational Resources Information Center

    Heidemann, Winfried

    1991-01-01

    Discusses effects of integration of the European Community and internal market on qualifications for occupational activity. Describes German objections to the community's attempts to set educational policy. Urges common community definitions of professions and recognition of vocational qualifications to facilitate freedom of movement of the work…

  7. Vocational Educators' Qualifications: A Pedagogical Poor Relation?

    ERIC Educational Resources Information Center

    Smith, Erica; Grace, Lauri

    2011-01-01

    This paper uses data from a recent national project on workforce development for vocational education and training (VET) practitioners in the service skills sector to examine the issue of teaching qualifications for VET practitioners in Australia. Data on the level of qualifications is limited and incomplete (Mlotkowski & Guthrie, 2010) and the…

  8. IHE material qualification tests description and criteria

    SciTech Connect

    Slape, R J

    1984-06-01

    This report describes the qualification tests presently being used at Pantex Plant, Lawrence Livermore National Laboratory, and Los Alamos National Laboratory that are required by the Department of Energy prior to the approval for an explosive as an Insensitive High Explosive (IHE) material. The acceptance criteria of each test for IHE qualification is also discussed. 5 references, 10 figures.

  9. 28 CFR 115.402 - Auditor qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Auditor qualifications. 115.402 Section 115.402 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Auditing and Corrective Action § 115.402 Auditor qualifications. (a) An audit shall be...

  10. 28 CFR 115.402 - Auditor qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Auditor qualifications. 115.402 Section 115.402 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Auditing and Corrective Action § 115.402 Auditor qualifications. (a) An audit shall be...

  11. 28 CFR 115.402 - Auditor qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Auditor qualifications. 115.402 Section 115.402 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) PRISON RAPE ELIMINATION ACT NATIONAL STANDARDS Auditing and Corrective Action § 115.402 Auditor qualifications. (a) An audit shall be...

  12. Commercial Parts Technology Qualification Processes

    NASA Technical Reports Server (NTRS)

    Cooper, Mark S.

    2013-01-01

    Many high-reliability systems, including space systems, use selected commercial parts (including Plastic Encapsulated Microelectronics or PEMs) for unique functionality, small size, low weight, high mechanical shock resistance, and other factors. Predominantly this usage is subjected to certain 100% tests (typically called screens) and certain destructive tests usually (but not always) performed on the flight lot (typically called qualification tests). Frequently used approaches include those documented in EEE-INST-002 and JPL DocID62212 (which are sometimes modified by the particular aerospace space systems manufacturer). In this study, approaches from these documents and several space systems manufacturers are compared to approaches from a launch systems manufacturer (SpaceX), an implantable medical electronics manufacturer (Medtronics), and a high-reliability transport system process (automotive systems). In the conclusions section, these processes are outlined for all of these cases and presented in tabular form. Then some simple comparisons are made. In this introduction section, the PEM technology qualification process is described, as documented in EEE-INST-002 (written by the Goddard Space Flight Center, GSFC), as well as the somewhat modified approach employed at the Jet Propulsion Laboratory (JPL). Approaches used at several major NASA contractors are also described

  13. Methods Data Qualification Interim Report

    SciTech Connect

    R. Sam Alessi; Tami Grimmett; Leng Vang; Dave McGrath

    2010-09-01

    The overall goal of the Next Generation Nuclear Plant (NGNP) Data Management and Analysis System (NDMAS) is to maintain data provenance for all NGNP data including the Methods component of NGNP data. Multiple means are available to access data stored in NDMAS. A web portal environment allows users to access data, view the results of qualification tests and view graphs and charts of various attributes of the data. NDMAS also has methods for the management of the data output from VHTR simulation models and data generated from experiments designed to verify and validate the simulation codes. These simulation models represent the outcome of mathematical representation of VHTR components and systems. The methods data management approaches described herein will handle data that arise from experiment, simulation, and external sources for the main purpose of facilitating parameter estimation and model verification and validation (V&V). A model integration environment entitled ModelCenter is used to automate the storing of data from simulation model runs to the NDMAS repository. This approach does not adversely change the why computational scientists conduct their work. The method is to be used mainly to store the results of model runs that need to be preserved for auditing purposes or for display to the NDMAS web portal. This interim report demonstrates the currently development of NDMAS for Methods data and discusses data and its qualification that is currently part of NDMAS.

  14. Teacher Qualification and Instructional Delivery Modes at the Preschool Level in Nigeria

    ERIC Educational Resources Information Center

    Odinko, Monica N.; Williams, Joanne M.; Donn, Gari

    2009-01-01

    Through this study researchers sought to evaluate the effects of qualification on instructional delivery modes of practicing preschool teachers in Nigeria. The sample consisted of 93 preschool teachers and 2,859 pupils aged 4 to 5 years. Schools were selected through stratified random sampling to ensure adequate representation of private, public,…

  15. 14 CFR 121.915 - Continuing qualification curriculum.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... qualification cycle. A continuing qualification cycle that ensures that during each cycle each person qualified..., technical skills, and cognitive skills required for initial qualification in accordance with the approved... continuing qualification cycle must include at least the following: (1) Evaluation period. Initially...

  16. From Old to New: The Australian Qualifications Framework

    ERIC Educational Resources Information Center

    Wheelahan, Leesa

    2011-01-01

    The Australian Qualifications Framework (AQF) is a "first generation" qualifications framework that was established in 1995. Its purpose was to create "a comprehensive, nationally consistent yet flexible framework for all qualifications in post-compulsory education and training." It encompasses all post-compulsory qualifications in Australia,…

  17. Qualification of the scorpion helmet cueing system

    NASA Astrophysics Data System (ADS)

    Atac, Robert; Bugno, Tony

    2011-06-01

    Gentex Corporation won the Helmet Mounted Integrated Targeting (HMIT) contract with the Air National Guard and Air Force Reserve in May 2010 along with Raytheon Technical Services Corporation as the prime contractor. The HMIT program involves qualification and installation of the Scorpion HMCS Color HMD in both the A-10C and F-16C Block 30 aircraft types. Qualification tests include all aspects from ejection safety, to NVG and pilot compatibility as well as performance testing. This paper will review the qualification testing results and program status along with any lessons learned.

  18. Benefits of Digital Equipment Generic Qualification Activities

    SciTech Connect

    Thomas, James E.; Steiman, Samuel C.

    2002-07-01

    As a result of nuclear power plant instrumentation and control obsolescence issues, there have been numerous activities during recent years relating to the qualification of digital equipment. Some of these activities have been 'generic' in nature in that the qualification was not limited to plant specific applications, but was intended to cover a broad base of potential applications of the digital equipment. These generic qualifications have been funded by equipment manufacturers and by utility groups and organizations. The generic activities sponsored by the Electric Power Research Institute (EPRI) have been pilot projects for an overall generic qualification approach. The primary benefit resulting from the generic qualification work to date is that a number of digital platforms and digital devices are now available for use in various nuclear safety-related applications. Many of the tests and evaluations necessary to support plant specific applications have been completed. The amount of data and documentation that each utility must develop on a case by case basis has been significantly reduced. There are also a number of additional benefits resulting from these industry efforts. The challenges and difficulties in qualifying digital equipment for safety-related applications are now more clearly understood. EPRI has published a lessons learned document (EPRI Report 1001452, Generic Qualification of Commercial Grade Digital Devices: Lessons Learned from Initial Pilots, which covers several different qualification areas, including device selection, project planning, vendor surveys and design reviews, and electromagnetic compatibility (EMC) qualification. Application of the experience and lessons learned from the EPRI pilot activities should help reduce the effort and cost required for future qualification work. Most generic qualification activities for commercial equipment have been conducted using the approach of EPRI TR-106439, Guideline on Evaluation and Acceptance

  19. Photoresist qualification using scatterometry CD

    NASA Astrophysics Data System (ADS)

    Volkovich, Roie; Avrahamov, Yosef; Cohen, Guy; Fallon, Patricia; Yin, Wenyan

    2012-03-01

    As the semiconductor industry advances to smaller design rules, Photoresist performance is critical for the tight lithography process. Critical Dimension (CD), Side Wall Angle (SWA) and Photoresist height, which are critical for the final semiconductor patterning, depend on the Photoresist chemistry. Each Photoresist batch has to be qualified to verify that it can achieve the required quality specifications. Photoresist qualification is done by exposing Photoresist and monitoring outcome after developing. In this work, Archer 300LCM scatterometry-based Optical CD (OCD) was evaluated using Dow 193 Immersion Top Coat Free Photoresist and Anti Reflection Layers (ARL). As part of the sensitivity analysis, changes in Photoresist thickness, ARL thickness and Photoresist formulation were evaluated. Results were compared to CD-SEM measurements. The CD sensitivity was evaluated on two grating dense line and space features with nominal Middle CD (MCD) values of 37nm and 75nm. Sensitivity of the OCD for Photoresist parameters was demonstrated.

  20. Direct qualification of digital components

    SciTech Connect

    Lawrence, J. D., LLNL

    1998-07-08

    Existing methods for qualifying digital system software for use in safety critical systems are expensive and are based on inferences that are of doubtful validity. This report on work-in-progress describes a new approach to qualifying a class of small safety systems that can meet a number of design restrictions, where the restrictions are carefully crafted to permit safety qualification to be determined by means of static analysis of the software combined with a limited amount of testing. This approach differs from attempts to qualify unrestricted programs in the general case. Work that has been accomplished towards this goal is discussed in summary terms. The technique relies on transforming a program into a form of directed graph known as a flowgraph. Existing testing theory is used, sometimes with minor modifications, to derive a set of design restrictions that permit reasoning about safety properties of the program, based on analysis and limited testing. Future work required to complete the research is outlined.

  1. Formal [4+2] annulation of enaminones and cyanomethyl sulfur ylide: one-pot access to polysubstituted pyridin-2(1H)-ones.

    PubMed

    Zhang, Qian; Liu, Xu; Xin, Xiaoqing; Zhang, Rui; Liang, Yongjiu; Dong, Dewen

    2014-12-18

    A facile and efficient one-pot synthesis of polysubstituted pyridin-2(1H)-ones from readily available enaminones and the cyanomethyl sulfonium bromide salt in the presence of cesium carbonate is developed, and a mechanism involving sequential nucleophilic vinylic substitution (S(N)V), intramolecular nucleophilic cyclization and dealkylation reactions is proposed. PMID:25349951

  2. BIGINELLI REACTION IN AQUEOUS MEDIUM: A GREENER AND SUSTAINABLE APPROACH TO SUBSTITUTED 3,4-DIHYDROPYRIMIDIN-2(1H)-ONES

    EPA Science Inventory

    An environmentally benign aqueous Biginelli protocol for the synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones using polystyrenesulfonic acid (PSSA) as a catalyst has been achieved. These microwave-assisted reactions proceed efficiently in water in the absence of organic s...

  3. 43 CFR 3141.6-4 - Qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.6-4 Qualifications. Each bidder shall submit with the bid a statement over...

  4. 43 CFR 3141.6-4 - Qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.6-4 Qualifications. Each bidder shall submit with the bid a statement over...

  5. 43 CFR 3141.6-4 - Qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.6-4 Qualifications. Each bidder shall submit with the bid a statement over...

  6. 43 CFR 3141.6-4 - Qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) LEASING IN SPECIAL TAR SAND AREAS Leasing in Special Tar Sand Areas § 3141.6-4 Qualifications. Each bidder shall submit with the bid a statement over...

  7. 9 CFR 2.32 - Personnel qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AGRICULTURE ANIMAL WELFARE REGULATIONS Research Facilities § 2.32 Personnel qualifications. (a) It shall be the responsibility of the research facility to ensure that all scientists, research technicians... of personnel reviewed, with sufficient frequency to fulfill the research facility's...

  8. 9 CFR 2.32 - Personnel qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AGRICULTURE ANIMAL WELFARE REGULATIONS Research Facilities § 2.32 Personnel qualifications. (a) It shall be the responsibility of the research facility to ensure that all scientists, research technicians... of personnel reviewed, with sufficient frequency to fulfill the research facility's...

  9. 9 CFR 2.32 - Personnel qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AGRICULTURE ANIMAL WELFARE REGULATIONS Research Facilities § 2.32 Personnel qualifications. (a) It shall be the responsibility of the research facility to ensure that all scientists, research technicians... of personnel reviewed, with sufficient frequency to fulfill the research facility's...

  10. 9 CFR 2.32 - Personnel qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AGRICULTURE ANIMAL WELFARE REGULATIONS Research Facilities § 2.32 Personnel qualifications. (a) It shall be the responsibility of the research facility to ensure that all scientists, research technicians... of personnel reviewed, with sufficient frequency to fulfill the research facility's...

  11. 9 CFR 2.32 - Personnel qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AGRICULTURE ANIMAL WELFARE REGULATIONS Research Facilities § 2.32 Personnel qualifications. (a) It shall be the responsibility of the research facility to ensure that all scientists, research technicians... of personnel reviewed, with sufficient frequency to fulfill the research facility's...

  12. 47 CFR 3.10 - Basic qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... AUTHORITIES IN MARITIME AND MARITIME MOBILE-SATELLITE RADIO SERVICES Eligibility § 3.10 Basic qualifications....S. licensed vessels in the maritime mobile or maritime mobile-satellite services without...

  13. Expedition 32 Final Soyuz Qualification Exams

    NASA Video Gallery

    Expedition 32 Flight Engineers Suni Williams, Yuri Malenchenko and Aki Hoshide take their final Soyuz systems qualification exams at the Gagarin Cosmonaut Training Center in Star City, Russia. The ...

  14. 24 CFR 3286.511 - Inspector qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... least one of the following qualifications is permitted to review the work and verify the installation of...: Administrator, Office of Manufactured Housing Programs, HUD, 451 Seventh Street, SW., Room 9164, Washington,...

  15. 5 CFR 319.301 - Qualifications standards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Qualifications standards. 319.301 Section 319.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT... are required in the ST position....

  16. 5 CFR 319.301 - Qualifications standards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Qualifications standards. 319.301 Section 319.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT... are required in the ST position....

  17. 5 CFR 319.301 - Qualifications standards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Qualifications standards. 319.301 Section 319.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT... are required in the ST position....

  18. 5 CFR 319.301 - Qualifications standards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Qualifications standards. 319.301 Section 319.301 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS EMPLOYMENT... are required in the ST position....

  19. Qualification needs for advanced integrated aircraft

    NASA Technical Reports Server (NTRS)

    Mackall, D. A.

    1985-01-01

    In an effort to achieve maximum aircraft performance, designers are integrating aircraft systems. The characteristics of aerodynamics, vehicle structure, and propulsion systems are being integrated and controlled through embedded, often flight critical, electronic systems. The qualification needs for such highly integrated aircraft systems are addressed. Based on flight experience with research aircraft, a set of test capabilities is described which allows for complete and efficient qualification of advanced integrated aircraft.

  20. Microwave spectra and gas phase structural parameters for N-hydroxypyridine-2(1H)-thione.

    PubMed

    Daly, Adam M; Mitchell, Erik G; Sanchez, Daniel A; Block, Eric; Kukolich, Stephen G

    2011-12-22

    The microwave spectrum for N-hydroxypyridine-2(1H)-thione (pyrithione) was measured in the frequency range 6-18 GHz, providing accurate rotational constants and nitrogen quadrupole coupling strengths for three isotopologues, C(5)H(4)(32)S(14)NOH, C(5)H(4)(32)S(14)NOD, and C(5)H(4)(34)S(14)NOH. Pyrithione was found to be in a higher concentration in the gas phase than the other tautomer, 2-mercaptopyridine-N-oxide (MPO). Microwave spectroscopy is best suited to determine which structure predominates in the gas phase. The measured rotational constants were used to accurately determine the coordinates of the substituted atoms and provided sufficient data to determine some of the important structural parameters for pyrithione, the only tautomer observed in the present work. The spectra were obtained using a pulsed-beam Fourier transform microwave spectrometer, with sufficient resolution to allow accurate measurements of the (14)N nuclear quadrupole hyperfine interactions. Ab initio calculations provided structural parameters and quadrupole coupling strengths that are in very good agreement with measured values. The experimental rotational constants for the parent compound are A = 3212.10(1), B = 1609.328(7), and C = 1072.208(6) MHz, yielding the inertial defect Δ(0) = -0.023 amu·Å(2) for the C(5)H(4)(32)S(14)NOH isotopologue. The observed near zero inertial defect clearly indicates a planar structure. The least-squares fit structural analysis yielded the experimental bond lengths R(O-H) = 0.93(2) Å, R(C-S) = 1.66(2) Å, and angle (N-O-H) = 105(4)° for the ground state structure. PMID:22070758

  1. Unit Standards Catalogue. Unit Standards and Qualifications Registered on the National Qualifications Framework to March 1994.

    ERIC Educational Resources Information Center

    New Zealand Qualifications Authority, Wellington.

    This booklet includes the latest list of unit standards and qualifications registered on the New Zealand National Qualifications Framework to April 1994. Unit standards registered on the framework can be offered by private and government training establishments, polytechnics, colleges of education, and schools. This list of registered unit…

  2. 14 CFR 60.27 - Automatic loss of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Automatic loss of qualification and procedures for restoration of qualification. 60.27 Section 60.27 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL...

  3. 14 CFR 60.29 - Other losses of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Other losses of qualification and procedures for restoration of qualification. 60.29 Section 60.29 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL...

  4. 14 CFR 60.27 - Automatic loss of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Automatic loss of qualification and procedures for restoration of qualification. 60.27 Section 60.27 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL...

  5. 14 CFR 60.29 - Other losses of qualification and procedures for restoration of qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Other losses of qualification and procedures for restoration of qualification. 60.29 Section 60.29 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL...

  6. Qualification of improved joint heaters

    NASA Technical Reports Server (NTRS)

    Cook, M.

    1989-01-01

    Qualification testing of the Redesigned Solid Rocket Motor improved igniter-to-case joint and field joint heaters was conducted on the fired TEM-04 static test motor and was completed on 7 Sep. 1989. The purpose of the test was to certify the installation and performance of the improved joint heaters for use on flight motors. The changes incorporated in the improved heaters improve durability and should reduce handling damage. The igniter-to-case joint and field joint primary heater circuits were subjected to five 20-hr ON cycles. The heater redundant circuits were then subjected to one 20-hr ON cycle. Voltage, current, and temperature set point values were maintained within the specified limits for both heaters during each ON cycle. When testing was complete, both heaters were removed and inspected. No discolorations or any other anomalies were found on either of the heaters. Based on the successful completion of this test, it is recommended that the improved igniter-to-case joint and field joint heaters be used on future flight motors.

  7. The Recognition of Occupational Skills and Educational Qualifications within the EEC.

    ERIC Educational Resources Information Center

    Bertrand, Olivier

    1992-01-01

    A survey conducted in France, Germany, Italy, Spain, and the United Kingdom analyzed employment practices and viewpoints of the social partners regarding comparability of qualifications and geographical mobility. Carried out in late 1991 with a limited sampling of respondents (firms, employers' organizations, and unions), the survey focused…

  8. The Impact of Part-Time Jobs in Years 12 and 13 on Qualification Achievement.

    ERIC Educational Resources Information Center

    Payne, Joan

    2003-01-01

    Presents data from nationally representative sample of the England/Wales Youth Cohort Study, describing patterns of paid work among full-time students in Years 12/13 working for qualifications. Shows paid work of a few hours has negligible impact on "A" level grades, but long working hours significantly reduce grades. (BT)

  9. Differentiated Quality Assurance for the African Virtual University's Teacher Education Qualification in Mathematics and Science

    ERIC Educational Resources Information Center

    Hattingh, A.

    2008-01-01

    For the African Virtual University and its consortium of African universities the implementation of quality promoting initiatives are not without challenges and scepticisms. To be discussed in this article is the case of a teacher education qualification in ten different African countries. Seven countries were sampled and visited in 2006 with the…

  10. Performance, Thermal, and Vibration Qualification Testing of Zetec Acoustic Transducers, Model Z0002659-2, Sondicator Probes

    SciTech Connect

    Jacobson, G; Gemberling, S; Lavietes, A

    2006-03-10

    This report is a result of Qualification Test Plan No.001 prepared by Anthony Lavietes. The Qualification Test Plan outlines a list of requirements for thermal and vibrational testing of Zetac's Z0002659-2 Sondicator Probe acoustic transducers (hereafter called ''transducers''). The Zetec transducers are used in a system that employs an array of 7 acoustic transducers. Qualification testing of these transducers was required since they are a modified version of a standard catalog item from the manufacturer. This report documents the thermal, vibrational, and performance testing that was performed on a sampling of these transducers in order to qualify them for flight. A total of 14 transducers were tested. All 14 passed qualification testing with no failures.

  11. Development Of A Macro-Batch Qualification Strategy For The Hanford Tank Waste Treatment And Immobilization Plant

    SciTech Connect

    Herman, Connie C.

    2013-09-30

    The Savannah River National Laboratory (SRNL) has evaluated the existing waste feed qualification strategy for the Hanford Tank Waste Treatment and Immobilization Plant (WTP) based on experience from the Savannah River Site (SRS) Defense Waste Processing Facility (DWPF) waste qualification program. The current waste qualification programs for each of the sites are discussed in the report to provide a baseline for comparison. Recommendations on strategies are then provided that could be implemented at Hanford based on the successful Macrobatch qualification strategy utilized at SRS to reduce the risk of processing upsets or the production of a staged waste campaign that does not meet the processing requirements of the WTP. Considerations included the baseline WTP process, as well as options involving Direct High Level Waste (HLW) and Low Activity Waste (LAW) processing, and the potential use of a Tank Waste Characterization and Staging Facility (TWCSF). The main objectives of the Hanford waste feed qualification program are to demonstrate compliance with the Waste Acceptance Criteria (WAC), determine waste processability, and demonstrate unit operations at a laboratory scale. Risks to acceptability and successful implementation of this program, as compared to the DWPF Macro-Batch qualification strategy, include: Limitations of mixing/blending capability of the Hanford Tank Farm; The complexity of unit operations (i.e., multiple chemical and mechanical separations processes) involved in the WTP pretreatment qualification process; The need to account for effects of blending of LAW and HLW streams, as well as a recycle stream, within the PT unit operations; and The reliance on only a single set of unit operations demonstrations with the radioactive qualification sample. This later limitation is further complicated because of the 180-day completion requirement for all of the necessary waste feed qualification steps. The primary recommendations/changes include the

  12. Efficient and economic HPLC performance qualification.

    PubMed

    Kaminski, Lukas; Degenhardt, Matthias; Ermer, Joachim; Feussner, Claus; Höwer-Fritzen, Heidemarie; Link, Peter; Renger, Bernd; Tegtmeier, Martin; Wätzig, Hermann

    2010-02-01

    Analytical instrument qualification (AIQ) is a prerequisite for any analytical method validation and thus must be considered as a vital basis of analytical data integrity and quality in pharmaceutical analysis. There is a well-established system of qualification phases-Design Qualification, Installation Qualification (IQ), Operational Qualification (OQ) and Performance Qualification (PQ). As HPLC systems are "off the shelf" equipment, Design Qualification may be disregarded here. IQ establishes that the instrument is received as designed and that it is properly installed. OQ is carried out modularly with the intention to ensure that the specific modules of the system and the whole system are operating according to the defined specifications. PQ as the last step of the initial qualification is supposed to ensure continued satisfactory performance of an instrument under actual running conditions over the anticipated working range during daily use. However, PQ is not a one time exercise, but is currently repeated regularly independently from routine use of the analytical system using standard reference test condition. But this approach, which is time consuming and expensive only provides a snapshot of system performance. As HPLC procedures generally require a system suitability test (SST) prior and/or after test, it might be far more reasonable and robust to use these SST data for a continuous PQ. The work presented here demonstrates that, under certain circumstances, satisfactory instrument performance assessment can be derived from system suitability tests and performance data from daily use as well. A generally accepted qualification list, consisting of only twelve critical parameters, was compiled in a first step. Some parameters such as injector or thermostatting accuracy were considered redundant while others were successfully incorporated in the proposed holistic approach. System suitability test data as well as OQ/PQ data were provided from different sources

  13. Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1.

    PubMed

    Liu, Zhiguo; Yu, Shufang; Chen, Di; Shen, Guoliang; Wang, Yu; Hou, Leping; Lin, Dan; Zhang, Jinsan; Ye, Faqing

    2016-01-01

    FGFR1 is well known as a molecular target in anticancer drug design. TKI258 plays an important role in RTK inhibitors. Utilizing TKI258 as a lead compound that contains a quinazolinone nucleus, we synthesized four series of 3-vinyl-quinoxalin-2(1H)-one derivatives, a total of 27 compounds. We further evaluated these compounds for FGFR1 inhibition ability as well as cytotoxicity against four cancer cell lines (H460, B16-F10, Hela229, and Hct116) in vitro. Some compounds displayed good-to-excellent potency against the four tested cancer cell lines compared with TKI258. Structure-activity relationship analyses indicated that small substituents at the side chain of the 3-vinyl-quinoxalin-2(1H)-one were more effective than large substituents. Lastly, we used molecular docking to obtain further insight into the interactions between the compounds and FGFR1. PMID:27217720

  14. Design, synthesis, and biological evaluation of 3-vinyl-quinoxalin-2(1H)-one derivatives as novel antitumor inhibitors of FGFR1

    PubMed Central

    Liu, Zhiguo; Yu, Shufang; Chen, Di; Shen, Guoliang; Wang, Yu; Hou, Leping; Lin, Dan; Zhang, Jinsan; Ye, Faqing

    2016-01-01

    FGFR1 is well known as a molecular target in anticancer drug design. TKI258 plays an important role in RTK inhibitors. Utilizing TKI258 as a lead compound that contains a quinazolinone nucleus, we synthesized four series of 3-vinyl-quinoxalin-2(1H)-one derivatives, a total of 27 compounds. We further evaluated these compounds for FGFR1 inhibition ability as well as cytotoxicity against four cancer cell lines (H460, B16-F10, Hela229, and Hct116) in vitro. Some compounds displayed good-to-excellent potency against the four tested cancer cell lines compared with TKI258. Structure–activity relationship analyses indicated that small substituents at the side chain of the 3-vinyl-quinoxalin-2(1H)-one were more effective than large substituents. Lastly, we used molecular docking to obtain further insight into the interactions between the compounds and FGFR1. PMID:27217720

  15. Unintended Consequences: How Qualification Constrains Innovation

    NASA Technical Reports Server (NTRS)

    Brice, Craig A.

    2011-01-01

    The development and implementation of new materials and manufacturing processes for aerospace application is often hindered by the high cost and long time span associated with current qualification procedures. The data requirements necessary for material and process qualification are extensive and often require millions of dollars and multiple years to complete. Furthermore, these qualification data can become obsolete for even minor changes to the processing route. This burden is a serious impediment to the pursuit of revolutionary new materials and more affordable processing methods for air vehicle structures. The application of integrated computational materials engineering methods to this problem can help to reduce the barriers to rapid insertion of new materials and processes. By establishing predictive capability for the development of microstructural features in relation to processing and relating this to critical property characteristics, a streamlined approach to qualification is possible. This paper critically examines the advantages and challenges to a modeling-assisted qualification approach for aerospace structural materials. An example of how this approach might apply towards the emerging field of additive manufacturing is discussed in detail.

  16. 4-Hydroxymethyl- and 4-methoxymethylfuro[2,3-h]quinolin-2(1H)-ones: synthesis and biological properties.

    PubMed

    Chilin, Adriana; Marzano, Cristina; Baccichetti, Francarosa; Simonato, Morena; Guiotto, Adriano

    2003-04-01

    4-Hydroxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one (HOFQ) was prepared by a new profitable way, which allowed to synthesize also 4-methoxymethyl-1,6,8-trimethylfuro[2,3-h]quinolin-2(1H)-one (MOFQ), and 4-hydroxymethyl-6,8-dimethylfuro[2,3-h]quinolin-2(1H)-one (HOHFQ). Some biological activities of the three compounds were studied in comparison with 8-MOP. In the dark, they inhibited topoisomerase II, leading to a moderate antiproliferative activity in mammalian cells. The antiproliferative activity was also tested upon UVA irradiation in mammalian cells: all compounds showed higher activity than 8-MOP, without mutagenicity and skin phototoxicity, with the best results for HOFQ. Photobinding to DNA was investigated, demonstrating a different sequence specificity for these furoquinolinones in comparison with furocoumarins. For all these features, HOFQ and the other analogues appeared very promising photochemotherapeutic agents, whose mechanism of action will be further investigated. PMID:12628658

  17. 14 CFR 121.463 - Aircraft dispatcher qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Aircraft dispatcher qualifications. 121.463... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Aircraft Dispatcher Qualifications and Duty Time...: Domestic, Flag, and Supplemental Operations § 121.463 Aircraft dispatcher qualifications. (a)...

  18. 14 CFR 121.463 - Aircraft dispatcher qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Aircraft dispatcher qualifications. 121.463... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Aircraft Dispatcher Qualifications and Duty Time...: Domestic, Flag, and Supplemental Operations § 121.463 Aircraft dispatcher qualifications. (a)...

  19. 14 CFR 121.463 - Aircraft dispatcher qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Aircraft dispatcher qualifications. 121.463... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Aircraft Dispatcher Qualifications and Duty Time...: Domestic, Flag, and Supplemental Operations § 121.463 Aircraft dispatcher qualifications. (a)...

  20. 28 CFR 34.109 - Qualifications of peer reviewers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Qualifications of peer reviewers. 34.109 Section 34.109 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.109 Qualifications of peer reviewers. The general reviewer qualification criteria...

  1. 28 CFR 34.109 - Qualifications of peer reviewers.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Qualifications of peer reviewers. 34.109 Section 34.109 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.109 Qualifications of peer reviewers. The general reviewer qualification criteria...

  2. 28 CFR 34.109 - Qualifications of peer reviewers.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Qualifications of peer reviewers. 34.109 Section 34.109 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.109 Qualifications of peer reviewers. The general reviewer qualification criteria...

  3. 28 CFR 34.109 - Qualifications of peer reviewers.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Qualifications of peer reviewers. 34.109 Section 34.109 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.109 Qualifications of peer reviewers. The general reviewer qualification criteria...

  4. 10 CFR Appendix H to Part 73 - Weapons Qualification Criteria

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 2 2013-01-01 2013-01-01 false Weapons Qualification Criteria H Appendix H to Part 73.... H Appendix H to Part 73—Weapons Qualification Criteria The B-27 Target or a target of equivalent difficulty will be used for all weapon qualification testing. Table H-1—Minimum Day Firing Criteria 1...

  5. 10 CFR Appendix H to Part 73 - Weapons Qualification Criteria

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 2 2014-01-01 2014-01-01 false Weapons Qualification Criteria H Appendix H to Part 73.... H Appendix H to Part 73—Weapons Qualification Criteria The B-27 Target or a target of equivalent difficulty will be used for all weapon qualification testing. Table H-1—Minimum Day Firing Criteria 1...

  6. 10 CFR Appendix H to Part 73 - Weapons Qualification Criteria

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Weapons Qualification Criteria H Appendix H to Part 73.... H Appendix H to Part 73—Weapons Qualification Criteria The B-27 Target or a target of equivalent difficulty will be used for all weapon qualification testing. Table H-1—Minimum Day Firing Criteria 1...

  7. 28 CFR 34.109 - Qualifications of peer reviewers.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Qualifications of peer reviewers. 34.109 Section 34.109 Judicial Administration DEPARTMENT OF JUSTICE OJJDP COMPETITION AND PEER REVIEW PROCEDURES Peer Review § 34.109 Qualifications of peer reviewers. The general reviewer qualification criteria...

  8. 49 CFR 180.507 - Qualification of tank cars.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Qualification of tank cars. 180.507 Section 180... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.507 Qualification of tank cars. (a) Each tank car marked as meeting a “DOT” specification or any other tank car used for the...

  9. 49 CFR 180.507 - Qualification of tank cars.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Qualification of tank cars. 180.507 Section 180... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.507 Qualification of tank cars. (a) Each tank car marked as meeting a “DOT” specification or any other tank car used for the...

  10. 49 CFR 180.507 - Qualification of tank cars.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Qualification of tank cars. 180.507 Section 180... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.507 Qualification of tank cars. (a) Each tank car marked as meeting a “DOT” specification or any other tank car used for the...

  11. 14 CFR 60.7 - Sponsor qualification requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Sponsor qualification requirements. 60.7 Section 60.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.7 Sponsor qualification requirements. (a) A...

  12. 12 CFR 611.210 - Director qualifications and training.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Director qualifications and training. 611.210... Association Board of Directors § 611.210 Director qualifications and training. (a) Qualifications. (1) Each bank and association board of directors must establish and maintain a policy identifying...

  13. 12 CFR 611.210 - Director qualifications and training.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Director qualifications and training. 611.210... Association Board of Directors § 611.210 Director qualifications and training. (a) Qualifications. (1) Each bank and association board of directors must establish and maintain a policy identifying...

  14. 12 CFR 611.210 - Director qualifications and training.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Director qualifications and training. 611.210... Association Board of Directors § 611.210 Director qualifications and training. (a) Qualifications. (1) Each bank and association board of directors must establish and maintain a policy identifying...

  15. 49 CFR 1546.411 - Continuing qualifications of screening personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Continuing qualifications of screening personnel... CARRIER SECURITY Screener Qualifications When the Foreign Air Carrier Conducts Screening § 1546.411 Continuing qualifications of screening personnel. (a) Impairment. No individual may perform a...

  16. 49 CFR 1546.405 - Qualifications of screening personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Qualifications of screening personnel. 1546.405... SECURITY Screener Qualifications When the Foreign Air Carrier Conducts Screening § 1546.405 Qualifications of screening personnel. (a) No individual subject to this subpart may perform a screening...

  17. On the Functions of a System of Vocational Qualifications

    ERIC Educational Resources Information Center

    Lum, Gerard

    2015-01-01

    While acknowledging that a system of vocational qualifications might be perceived as having any number of possible purposes, this paper identifies three primary functions that any vocational qualification must fulfil by dint of being a vocational qualification. It is argued that current arrangements are unable to fulfil these essential functions…

  18. 46 CFR 56.75-20 - Brazing qualification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Brazing qualification. 56.75-20 Section 56.75-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING PIPING SYSTEMS AND APPURTENANCES Brazing § 56.75-20 Brazing qualification. (a) The qualification of the performance of brazers and brazing operators shall be in...

  19. 10 CFR 603.515 - Qualification of a consortium.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 4 2013-01-01 2013-01-01 false Qualification of a consortium. 603.515 Section 603.515 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Recipient Qualification § 603.515 Qualification of a consortium. (a) A consortium...

  20. 10 CFR 603.515 - Qualification of a consortium.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Qualification of a consortium. 603.515 Section 603.515 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Recipient Qualification § 603.515 Qualification of a consortium. (a) A consortium...

  1. 10 CFR 603.515 - Qualification of a consortium.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Qualification of a consortium. 603.515 Section 603.515 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Recipient Qualification § 603.515 Qualification of a consortium. (a) A consortium that is not formally incorporated...

  2. 10 CFR 603.515 - Qualification of a consortium.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Qualification of a consortium. 603.515 Section 603.515 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Recipient Qualification § 603.515 Qualification of a consortium. (a) A consortium...

  3. 46 CFR 57.05-3 - Limited space qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Limited space qualifications. 57.05-3 Section 57.05-3... Performance Qualifications § 57.05-3 Limited space qualifications. When a welder is to be qualified for welding or torch brazing of piping on board ship in a limited or restricted space, the space...

  4. 43 CFR 3472.2-5 - Special qualifications, public bodies.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Special qualifications, public bodies... PROVISIONS AND LIMITATIONS Lease Qualification Requirements § 3472.2-5 Special qualifications, public bodies... public body shall submit: (1) Evidence of the manner in which it is organized; (2) Evidence that it...

  5. 49 CFR 180.507 - Qualification of tank cars.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Qualification of tank cars. 180.507 Section 180... MAINTENANCE OF PACKAGINGS Qualification and Maintenance of Tank Cars § 180.507 Qualification of tank cars. (a) Each tank car marked as meeting a “DOT” specification or any other tank car used for the...

  6. 46 CFR 57.05-2 - Transfer of performance qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Transfer of performance qualifications. 57.05-2 Section 57.05-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING WELDING AND BRAZING Performance Qualifications § 57.05-2 Transfer of performance qualifications. (a)...

  7. 46 CFR 57.05-2 - Transfer of performance qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Transfer of performance qualifications. 57.05-2 Section 57.05-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING WELDING AND BRAZING Performance Qualifications § 57.05-2 Transfer of performance qualifications. (a)...

  8. 46 CFR 57.05-2 - Transfer of performance qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Transfer of performance qualifications. 57.05-2 Section 57.05-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING WELDING AND BRAZING Performance Qualifications § 57.05-2 Transfer of performance qualifications. (a)...

  9. 46 CFR 57.05-2 - Transfer of performance qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Transfer of performance qualifications. 57.05-2 Section 57.05-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING WELDING AND BRAZING Performance Qualifications § 57.05-2 Transfer of performance qualifications. (a)...

  10. 46 CFR 57.05-2 - Transfer of performance qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Transfer of performance qualifications. 57.05-2 Section 57.05-2 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING WELDING AND BRAZING Performance Qualifications § 57.05-2 Transfer of performance qualifications. (a)...

  11. 12 CFR 611.210 - Director qualifications and training.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Association Board of Directors § 611.210 Director qualifications and training. (a) Qualifications. (1) Each bank and association board of directors must establish and maintain a policy identifying desirable... board members, explaining how the desired qualifications were identified. The policy must...

  12. 14 CFR 121.453 - Flight engineer qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Flight engineer qualifications. 121.453... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Crewmember Qualifications § 121.453 Flight engineer qualifications. (a) No certificate holder may use any person nor may any person serve as a flight engineer on...

  13. 10 CFR Appendix H to Part 73 - Weapons Qualification Criteria

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Weapons Qualification Criteria H Appendix H to Part 73.... H Appendix H to Part 73—Weapons Qualification Criteria The B-27 Target or a target of equivalent difficulty will be used for all weapon qualification testing. Table H-1—Minimum Day Firing Criteria 1...

  14. 10 CFR Appendix H to Part 73 - Weapons Qualification Criteria

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Weapons Qualification Criteria H Appendix H to Part 73.... H Appendix H to Part 73—Weapons Qualification Criteria The B-27 Target or a target of equivalent difficulty will be used for all weapon qualification testing. Table H-1—Minimum Day Firing Criteria 1...

  15. 49 CFR 180.405 - Qualification of cargo tanks.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Qualification of cargo tanks. 180.405 Section 180.405 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) CONTINUING QUALIFICATION AND MAINTENANCE OF PACKAGINGS Qualification...

  16. 47 CFR 54.415 - Consumer qualification for Link Up.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 3 2011-10-01 2011-10-01 false Consumer qualification for Link Up. 54.415... qualification for Link Up. (a) In a state that mandates state Lifeline support, the consumer qualification criteria for Link Up shall be the same as the criteria that the state established for...

  17. 10 CFR 26.85 - Collector qualifications and responsibilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 1 2011-01-01 2011-01-01 false Collector qualifications and responsibilities. 26.85 Section 26.85 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Collecting Specimens for Testing § 26.85 Collector qualifications and responsibilities. (a) Urine collector qualifications....

  18. 10 CFR 26.85 - Collector qualifications and responsibilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Collector qualifications and responsibilities. 26.85 Section 26.85 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Collecting Specimens for Testing § 26.85 Collector qualifications and responsibilities. (a) Urine collector qualifications....

  19. 10 CFR 26.85 - Collector qualifications and responsibilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Collector qualifications and responsibilities. 26.85 Section 26.85 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Collecting Specimens for Testing § 26.85 Collector qualifications and responsibilities. (a) Urine collector qualifications....

  20. 10 CFR 26.85 - Collector qualifications and responsibilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 1 2014-01-01 2014-01-01 false Collector qualifications and responsibilities. 26.85 Section 26.85 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Collecting Specimens for Testing § 26.85 Collector qualifications and responsibilities. (a) Urine collector qualifications....

  1. 10 CFR 26.85 - Collector qualifications and responsibilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Collector qualifications and responsibilities. 26.85 Section 26.85 Energy NUCLEAR REGULATORY COMMISSION FITNESS FOR DUTY PROGRAMS Collecting Specimens for Testing § 26.85 Collector qualifications and responsibilities. (a) Urine collector qualifications....

  2. 14 CFR 121.453 - Flight engineer qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Flight engineer qualifications. 121.453... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Crewmember Qualifications § 121.453 Flight engineer qualifications. (a) No certificate holder may use any person nor may any person serve as a flight engineer on...

  3. 14 CFR 60.4 - Qualification Performance Standards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Qualification Performance Standards. 60.4 Section 60.4 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE § 60.4 Qualification Performance Standards....

  4. 46 CFR 57.05-3 - Limited space qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 2 2012-10-01 2012-10-01 false Limited space qualifications. 57.05-3 Section 57.05-3... Performance Qualifications § 57.05-3 Limited space qualifications. When a welder is to be qualified for welding or torch brazing of piping on board ship in a limited or restricted space, the space...

  5. 46 CFR 57.05-3 - Limited space qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 2 2014-10-01 2014-10-01 false Limited space qualifications. 57.05-3 Section 57.05-3... Performance Qualifications § 57.05-3 Limited space qualifications. When a welder is to be qualified for welding or torch brazing of piping on board ship in a limited or restricted space, the space...

  6. 46 CFR 57.05-3 - Limited space qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 2 2013-10-01 2013-10-01 false Limited space qualifications. 57.05-3 Section 57.05-3... Performance Qualifications § 57.05-3 Limited space qualifications. When a welder is to be qualified for welding or torch brazing of piping on board ship in a limited or restricted space, the space...

  7. 49 CFR 180.351 - Qualification of IBCs.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Qualification of IBCs. 180.351 Section 180.351 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... Qualification and Maintenance of IBCs § 180.351 Qualification of IBCs. (a) General. Each IBC used for...

  8. 49 CFR 180.351 - Qualification of IBCs.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Qualification of IBCs. 180.351 Section 180.351 Transportation Other Regulations Relating to Transportation (Continued) PIPELINE AND HAZARDOUS MATERIALS SAFETY... Qualification and Maintenance of IBCs § 180.351 Qualification of IBCs. (a) General. Each IBC used for...

  9. 10 CFR 603.515 - Qualification of a consortium.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Qualification of a consortium. 603.515 Section 603.515 Energy DEPARTMENT OF ENERGY (CONTINUED) ASSISTANCE REGULATIONS TECHNOLOGY INVESTMENT AGREEMENTS Pre-Award Business Evaluation Recipient Qualification § 603.515 Qualification of a consortium. (a) A consortium...

  10. 40 CFR 35.937-3 - Evaluation of qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Evaluation of qualifications. 35.937-3... Evaluation of qualifications. (a) The grantee shall review the qualifications of firms which responded to the... considered in the evaluation of candidates for submission of proposals should include: (1)...

  11. 14 CFR 121.463 - Aircraft dispatcher qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Aircraft dispatcher qualifications. 121.463... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Aircraft Dispatcher Qualifications and Duty Time...: Domestic, Flag, and Supplemental Operations § 121.463 Aircraft dispatcher qualifications. (a)...

  12. 46 CFR 57.05-3 - Limited space qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 2 2011-10-01 2011-10-01 false Limited space qualifications. 57.05-3 Section 57.05-3... Performance Qualifications § 57.05-3 Limited space qualifications. When a welder is to be qualified for welding or torch brazing of piping on board ship in a limited or restricted space, the space...

  13. [Drivers license qualification for epileptics].

    PubMed

    Egli, M; Hartmann, H; Hess, R

    1977-03-26

    The question whether a person with epilepsy qualified for a driving licence must be examined from the point of view of the individual as well as that of the community. The general public should be protected against unduly high risks from epileptic drivers, whereas the patient has a right to live as normal a life as possible, which includes driving an automobile. Too rigid criteria for obtaining the license increase the number of persons who evade medical control and drive "illegally". To require physicians to report their epileptic patients to the authorities would be counterproductive; it would also destroy the personal confidence between physician and patient which is so essential for successful treatment. Epileptic persons endanger safety on the road only slightly: 0.1-0.3% of all traffic accidents are due to epileptic seizures. In contrast, abuse of alcohol plays a major role in 6-9% of all accidents, whereas 80-90% are attributable to evident mistakes by the driver. Epileptic patients under regular medical supervision who are licenced on grounds of approved criteria do not cause more accidents than the general population. A dangerous group are, however, those with mental alterations (organic or reactive) and particularly patients with aggressive and expansive-compensatory traits, as well as those driving without permission. Prognostic criteria as to the further course of the disease are paramount for the assessment of qualification for the licence. The following rules have proved their worth: 2 years freedom from seizures (with or without therapy), no abnormalities specific for epilepsy in the EEG, no serious mental changes, regular medical supervision and treatment mus be guaranteed. Departures from these rules should be confined to exceptional cases with the consent of a physician specialized in epileptology. The same holds for admission to higher categories of driving licence, the only practical eventuality being category D (lorries), and even this only in

  14. Round table discussion " Development of qualification framework in meteorology (TEMPUS QUALIMET)"

    NASA Astrophysics Data System (ADS)

    Bashmakova, I.; Belotserkovsky, A.; Karlin, L.; Petrosyan, A.; Serditova, N.; Zilitinkevich, S.

    2010-09-01

    The international consortium has started implementing a project aimed at the development of unified framework of qualifications in meteorology (QualiMet), setting a system of recognition and award of qualifications up to Doctoral level based on standards of knowledge, skill and competence acquired by learners is underway. The QualiMet has the following specific objectives: 1. To develop standards of knowledge, skills and competence for all qualifications up to Doctoral level needed in all possible occupations meteorology learner can undertake, by July 2011 2. To develop reciprocally recognized rubrics, criteria, methods and tools for assessing the compliance with the developed standards (quality assurance), by July 2012 3. To set the network of Centers of Excellence as the primary designer of sample education programs and learning experiences, both in brick-and-mortar and distant setting of delivery, leading to achievement of the developed standards, by December 2012 4. To set a system of mutual international recognition and award of qualifications in meteorology based on the developed procedures and establishment of self-regulatory public organization, by December 2012 The main beneficiaries of the project are: 1. Meteorology learners from the consortium countries. They will be able to make informed decisions about available qualification choices and progression options and provided an opportunity for students and graduates to participate in the system of international continuous education. 2. Meteorology employers from the consortium countries, They will be able to specify the level of knowledge, skill and competence required for occupational roles, evaluate qualifications presented, connect training and development with business needs. 3. Students and academic staff of all the consortium members, who will gain the increased mobility and exchange the fluxes of culturally and institutionally diversified lecturers and qualified specialists

  15. [The Traceability Management for Qualification Documents of Medical Instruments].

    PubMed

    Tang, Guoping; Hu, Liang; Xu, Xia; Fang, Zhiqiang; Hu, Juan

    2016-01-01

    The management for qualification documents of medical instruments is very important work to management department of medical instruments. Because the number of qualification documents of medical instruments is very large and they have an expiry date, it is difficult to manage them. This article discussed how to manage qualification documents of medical instruments, and an information management system that has a function of traceability management has been developed. This information management system standardizes management for qualification documents of medical instruments, and ensures that qualification documents of medical instruments are available and can be traced. Besides, it can reduce the amount of work for medical instruments management. PMID:27197505

  16. National Qualification Frameworks: Developing Research Perspectives

    ERIC Educational Resources Information Center

    Fernie, Scott; Pilcher, Nick

    2009-01-01

    Arguments for National Qualification Frameworks (NQF) are compelling. Indeed, such frameworks are now an international phenomenon. Yet, few studies take a critical perspective and challenge the broad assumptions underpinning NQF. Arguments presented in this paper attempt to open a debate within the higher education community that draws attention…

  17. 15 CFR 255.2 - Qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Qualifications. 255.2 Section 255.2 Commerce and Foreign Trade Regulations Relating to Commerce and Foreign Trade NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE FELLOWSHIPS AND RESEARCH ASSOCIATES FELLOWSHIPS IN LABORATORY STANDARDIZATION AND TESTING FOR...

  18. Educational Qualifications of UK Farmers: A Review.

    ERIC Educational Resources Information Center

    Gasson, Ruth

    1998-01-01

    No single source provides information on farmers' educational levels in the United Kingdom. Recent large surveys suggest that a third to half of UK farmers have pursued courses of further/higher education and obtained formal qualifications, largely in agricultural areas. Farmers' educational attainment is related to age, region, farm size and…

  19. AF Ni-Cd cell qualification program

    NASA Technical Reports Server (NTRS)

    Hall, Steve; Brown, Harry; Collins, G.; Hwang, Warren

    1994-01-01

    The present status of the USAF NiCd cell qualification program, which is underway at the Naval Surface Warfare Center-Crane Division, is summarized. The following topics are discussed: overview; background; purpose; stress tests; results for super Ni-Cd; results for SAFT cells; GPS stress test; GPS simulated orbit; and results for gates cells. The discussion is presented in viewgraph format.

  20. Roles, Responsibilities, and Qualifications for Reading Specialists.

    ERIC Educational Resources Information Center

    International Reading Association, Newark, DE.

    This document presents in outline form the roles, responsibilities, and qualifications of reading specialists as formulated by the Professional Standards and Ethics Committee and approved by the Board of Directors of the International Reading Association. The breakdown of roles, which are retained as outline headings in the sections on…

  1. 43 CFR 3453.1 - Qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Qualifications. 3453.1 Section 3453.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MANAGEMENT OF EXISTING LEASES Transfers by...

  2. 43 CFR 3453.1 - Qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Qualifications. 3453.1 Section 3453.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MANAGEMENT OF EXISTING LEASES Transfers by...

  3. 43 CFR 3453.1 - Qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Qualifications. 3453.1 Section 3453.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MANAGEMENT OF EXISTING LEASES Transfers by...

  4. 43 CFR 3453.1 - Qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Qualifications. 3453.1 Section 3453.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR MINERALS MANAGEMENT (3000) MANAGEMENT OF EXISTING LEASES Transfers by...

  5. 16 CFR 1204.15 - Qualification testing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 2 2012-01-01 2012-01-01 false Qualification testing. 1204.15 Section 1204.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR OMNIDIRECTIONAL CITIZENS BAND BASE STATION ANTENNAS Certification §...

  6. 16 CFR 1204.15 - Qualification testing.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false Qualification testing. 1204.15 Section 1204.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR OMNIDIRECTIONAL CITIZENS BAND BASE STATION ANTENNAS Certification §...

  7. 16 CFR 1204.15 - Qualification testing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false Qualification testing. 1204.15 Section 1204.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR OMNIDIRECTIONAL CITIZENS BAND BASE STATION ANTENNAS Certification §...

  8. 16 CFR 1204.15 - Qualification testing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Qualification testing. 1204.15 Section 1204.15 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT REGULATIONS SAFETY STANDARD FOR OMNIDIRECTIONAL CITIZENS BAND BASE STATION ANTENNAS Certification §...

  9. 42 CFR 485.70 - Personnel qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Personnel qualifications. 485.70 Section 485.70 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION CONDITIONS OF PARTICIPATION: SPECIALIZED PROVIDERS Conditions of Participation: Comprehensive...

  10. 7 CFR 1221.128 - Qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Qualification of Sorghum Producer... entitled to submit requests for funding to the Board pursuant to § 1221.112(j). Only one sorghum...

  11. 7 CFR 1221.128 - Qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Qualification of Sorghum Producer... entitled to submit requests for funding to the Board pursuant to § 1221.112(j). Only one sorghum...

  12. 7 CFR 1221.128 - Qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Qualification of Sorghum Producer... entitled to submit requests for funding to the Board pursuant to § 1221.112(j). Only one sorghum...

  13. 7 CFR 1221.128 - Qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Qualification of Sorghum Producer... entitled to submit requests for funding to the Board pursuant to § 1221.112(j). Only one sorghum...

  14. 42 CFR 485.604 - Personnel qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Personnel qualifications. 485.604 Section 485.604 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION CONDITIONS OF PARTICIPATION: SPECIALIZED PROVIDERS Conditions of Participation: Critical Access Hospitals (CAHs)...

  15. 5 CFR 302.202 - Qualification requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Qualification requirements. 302.202 Section 302.202 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... waiver by the agency of requirements as to age, height, and weight for each preference eligible when...

  16. Education, Economic Globalisation and National Qualifications Frameworks

    ERIC Educational Resources Information Center

    Lauder, Hugh

    2011-01-01

    There are many aims that have been articulated with respect to national qualifications frameworks (NQFs). Among them are those concerned with transparency, which is to say, that it is assumed that once employers understand the competencies of employees, as defined by their education credentials, then the mismatch between what employers are looking…

  17. 5 CFR 302.202 - Qualification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... EMPLOYMENT IN THE EXCEPTED SERVICE Eligibility Standards § 302.202 Qualification requirements. Before making... standards such as those relating to experience and training, citizenship, minimum age, physical condition... education. An agency shall not establish a maximum age requirement for any position. Each agency shall...

  18. 7 CFR 1724.4 - Qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 11 2011-01-01 2011-01-01 false Qualifications. 1724.4 Section 1724.4 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES General §...

  19. 7 CFR 1724.4 - Qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Qualifications. 1724.4 Section 1724.4 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES General §...

  20. 7 CFR 1724.4 - Qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Qualifications. 1724.4 Section 1724.4 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES General §...

  1. 7 CFR 1724.4 - Qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Qualifications. 1724.4 Section 1724.4 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES General §...

  2. 7 CFR 1724.4 - Qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Qualifications. 1724.4 Section 1724.4 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC ENGINEERING, ARCHITECTURAL SERVICES AND DESIGN POLICIES AND PROCEDURES General §...

  3. 42 CFR 441.565 - Provider qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 4 2012-10-01 2012-10-01 false Provider qualifications. 441.565 Section 441.565 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... right to train attendant care providers in the specific areas of attendant care needed by the...

  4. 42 CFR 441.565 - Provider qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 4 2014-10-01 2014-10-01 false Provider qualifications. 441.565 Section 441.565 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... right to train attendant care providers in the specific areas of attendant care needed by the...

  5. 42 CFR 441.565 - Provider qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 4 2013-10-01 2013-10-01 false Provider qualifications. 441.565 Section 441.565 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... right to train attendant care providers in the specific areas of attendant care needed by the...

  6. 42 CFR 485.705 - Personnel qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Personnel qualifications. 485.705 Section 485.705 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES... Participation for Clinics, Rehabilitation Agencies, and Public Health Agencies as Providers of...

  7. 42 CFR 410.134 - Provider qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider qualifications. For Medicare Part B coverage of MNT, only a registered dietitian or nutrition professional...

  8. 42 CFR 410.134 - Provider qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider qualifications. For Medicare Part B coverage of MNT, only a registered dietitian or nutrition professional...

  9. 42 CFR 410.134 - Provider qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider qualifications. For Medicare Part B coverage of MNT, only a registered dietitian or nutrition professional...

  10. Qualifications Frameworks: Implementation and Impact in Botswana

    ERIC Educational Resources Information Center

    Tau, Daniel; Modesto, Stanslaus T.

    2011-01-01

    A growing number of countries are introducing qualification frameworks (QFs) following a common definition of outcomes, level descriptors, and a set of occupational or knowledge fields. Botswana has been no exception to this trend. The passing of the Vocational Training Act (1998) led to the creation of the Botswana National Vocational…

  11. Achieving agility through parameter space qualification

    SciTech Connect

    Diegert, K.V.; Easterling, R.G.; Ashby, M.R.; Benavides, G.L.; Forsythe, C.; Jones, R.E.; Longcope, D.B.; Parratt, S.W.

    1995-02-01

    The A-primed (Agile Product Realization of Innovative electro-Mechanical Devices) project is defining and proving processes for agile product realization for the Department of Energy complex. Like other agile production efforts reported in the literature, A-primed uses concurrent engineering and information automation technologies to enhance information transfer. A unique aspect of our approach to agility is the qualification during development of a family of related product designs and their production processes, rather than a single design and its attendant processes. Applying engineering principles and statistical design of experiments, economies of test and analytic effort are realized for the qualification of the device family as a whole. Thus the need is minimized for test and analysis to qualify future devices from this family, thereby further reducing the design-to-production cycle time. As a measure of the success of the A-primed approach, the first design took 24 days to produce, and operated correctly on the first attempt. A flow diagram for the qualification process is presented. Guidelines are given for implementation, based on the authors experiences as members of the A-primed qualification team.

  12. 21 CFR 211.25 - Personnel qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Personnel qualifications. 211.25 Section 211.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Organization and Personnel §...

  13. 14 CFR 121.913 - Qualification curriculum.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Qualification curriculum. 121.913 Section 121.913 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIR CARRIERS AND OPERATORS FOR COMPENSATION OR HIRE: CERTIFICATION AND OPERATIONS...

  14. 42 CFR 485.705 - Personnel qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... Physical Therapy and Speech-Language Pathology Services § 485.705 Personnel qualifications. (a) General... involved in the furnishing of outpatient physical therapy, occupational therapy, and speech-language...) of the Act and the requirements in part 484 of this chapter. (2) For a speech-language...

  15. 42 CFR 485.705 - Personnel qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Physical Therapy and Speech-Language Pathology Services § 485.705 Personnel qualifications. (a) General... involved in the furnishing of outpatient physical therapy, occupational therapy, and speech-language...) of the Act and the requirements in part 484 of this chapter. (2) For a speech-language...

  16. 42 CFR 485.705 - Personnel qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... Physical Therapy and Speech-Language Pathology Services § 485.705 Personnel qualifications. (a) General... involved in the furnishing of outpatient physical therapy, occupational therapy, and speech-language...) of the Act and the requirements in part 484 of this chapter. (2) For a speech-language...

  17. 42 CFR 485.705 - Personnel qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Physical Therapy and Speech-Language Pathology Services § 485.705 Personnel qualifications. (a) General... involved in the furnishing of outpatient physical therapy, occupational therapy, and speech-language...) of the Act and the requirements in part 484 of this chapter. (2) For a speech-language...

  18. Qualifications and Skills: The Organisational Perspective

    ERIC Educational Resources Information Center

    Dafou, Efthimia

    2009-01-01

    This paper portrays the inferences that employers in Greece draw from particular aspects of study programmes, as recorded on educational qualifications. Based on semi-structured interviews with human resource managers in 37 industrial and service organisations and general directors of careers offices in eight higher education institutions, and…

  19. Mask qualification strategies in a wafer fab

    NASA Astrophysics Data System (ADS)

    Jaehnert, Carmen; Kunowski, Angela

    2007-02-01

    Having consistent high quality photo masks is one of the key factors in lithography in the wafer fab. Combined with stable exposure- and resist processes, it ensures yield increases in production and fast learning cycles for technology development and design evaluation. Preventive controlling of incoming masks and quality monitoring while using the mask in production is essential for the fab to avoid yield loss or technical problems caused by mask issues, which eventually result in delivery problems to the customer. In this paper an overview of the procedures used for mask qualification and production release, for both logic and DRAM, at Infineon Dresden is presented. Incoming qualification procedures, such as specification checks, incoming inspection, and inline litho process window evaluation, are described here. Pinching and electrical tests, including compatibility tests for mask copies for high volume products on optimized litho processes, are also explained. To avoid mask degradation over lifetime, re-inspection checks are done for re-qualification while using the mask in production. The necessity of mask incoming inspection and re-qualification, due to the repeater printing from either the processing defects of the original mask or degrading defects of being used in the fab (i.e. haze, ESD, and moving particles, etc.), is demonstrated. The need and impact of tight mask specifications, such as CD uniformity signatures and corresponding electrical results, are shown with examples of mask-wafer CD correlation.

  20. 21 CFR 211.25 - Personnel qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 4 2012-04-01 2012-04-01 false Personnel qualifications. 211.25 Section 211.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Organization and Personnel §...

  1. 21 CFR 211.25 - Personnel qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 4 2011-04-01 2011-04-01 false Personnel qualifications. 211.25 Section 211.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Organization and Personnel §...

  2. 21 CFR 211.25 - Personnel qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 4 2013-04-01 2013-04-01 false Personnel qualifications. 211.25 Section 211.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Organization and Personnel §...

  3. 21 CFR 211.25 - Personnel qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 4 2014-04-01 2014-04-01 false Personnel qualifications. 211.25 Section 211.25 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL CURRENT GOOD MANUFACTURING PRACTICE FOR FINISHED PHARMACEUTICALS Organization and Personnel §...

  4. 7 CFR 1221.128 - Qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE SORGHUM PROMOTION, RESEARCH, AND INFORMATION ORDER Sorghum Promotion, Research, and Information Order Qualification of Sorghum Producer... entitled to submit requests for funding to the Board pursuant to § 1221.112(j). Only one sorghum...

  5. 42 CFR 410.134 - Provider qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES MEDICARE PROGRAM SUPPLEMENTARY MEDICAL INSURANCE (SMI) BENEFITS Medical Nutrition Therapy § 410.134 Provider qualifications. For Medicare Part B coverage of MNT, only a registered dietitian or nutrition professional...

  6. 5 CFR 319.302 - Individual qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Individual qualifications. 319.302 Section 319.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... appointed to SL and ST positions. The agency head must determine that the individual meets...

  7. 5 CFR 319.302 - Individual qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 5 Administrative Personnel 1 2013-01-01 2013-01-01 false Individual qualifications. 319.302 Section 319.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... appointed to SL and ST positions. The agency head must determine that the individual meets...

  8. 5 CFR 319.302 - Individual qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Individual qualifications. 319.302 Section 319.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... appointed to SL and ST positions. The agency head must determine that the individual meets...

  9. 5 CFR 319.302 - Individual qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 5 Administrative Personnel 1 2011-01-01 2011-01-01 false Individual qualifications. 319.302 Section 319.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... appointed to SL and ST positions. The agency head must determine that the individual meets...

  10. 7 CFR 982.34 - Qualification.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Hazelnut Control Board § 982.34 Qualification. (a) Any person prior to... alternate member of the Board handles hazelnuts produced by other growers or becomes an employee or agent...

  11. 7 CFR 982.34 - Qualification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Hazelnut Control Board § 982.34 Qualification. (a) Any person prior to... alternate member of the Board handles hazelnuts produced by other growers or becomes an employee or agent...

  12. 7 CFR 982.34 - Qualification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Hazelnut Control Board § 982.34 Qualification. (a) Any person prior to... alternate member of the Board handles hazelnuts produced by other growers or becomes an employee or agent...

  13. 7 CFR 982.34 - Qualification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Hazelnut Control Board § 982.34 Qualification. (a) Any person prior to... alternate member of the Board handles hazelnuts produced by other growers or becomes an employee or agent...

  14. 7 CFR 982.34 - Qualification.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Hazelnut Control Board § 982.34 Qualification. (a) Any person prior to... alternate member of the Board handles hazelnuts produced by other growers or becomes an employee or agent...

  15. SULTAN measurement and qualification: ITER-US-LLNL-NMARTOVETSKY- 092008

    SciTech Connect

    Martovetsky, N N

    2006-09-21

    Measuring the characteristics of full scale ITER CICC at SULTAN is the critical qualification test. If volt-ampere characteristic (VAC) or volt-temperature characteristic (VTC) are distorted, the criterion of 10 uV/m may not be a valid criterion to judge the conductor performance. Only measurements with a clear absence or low signals from the current distribution should be considered as quantitatively representative, although in some obvious circumstances one can judge if a conductor will meet or fail ITER requirements. SULTAN full scale ITER CICC testing should be done with all measures taken to ensure uniform current redistribution. A full removal of Cr plating in the joint area and complete solder filling of the joints (with provision of the central channel for helium flow) should be mandatory for DC qualification samples for ITER. Also, T and I should be increased slowly that an equilibrium could be established for accurate measurement of Tcs, Ic and N. It is also desirable to go up in down in current and/or temperature (within stable range) to make sure that the equilibrium is reached.

  16. AGR-1 Data Qualification Interim Report

    SciTech Connect

    Machael Abbott

    2009-08-01

    Projects for the very-high-temperature reactor (VHTR) program provide data in support of Nuclear Regulatory Commission licensing of the VHTR. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high temperature and high fluence environments. The VHTR Program has established the NGNP Data Management and Analysis System (NDMAS) to ensure that VHTR data are (1) qualified for use, (2) stored in a readily accessible electronic form, and (3) analyzed to extract useful results. This document focuses on the first NDMAS objective. It describes the data streams associated with the first Advanced Gas Reactor (AGR-1) experiment, the processing of these data within NDMAS, and reports the interim FY09 qualification status of the AGR-1 data to date. Data qualification activities within NDMAS for specific types of data are determined by the data qualification category, which is assigned by the data generator, and include: (1) capture testing, to confirm that the data stored within NDMAS are identical to the raw data supplied, (2) accuracy testing, to confirm that the data are an accurate representation of the system or object being measured, and (3) documentation that the data were collected under an NQA-1 or equivalent QA program. The interim qualification status of the following four data streams is reported in this document: (1) fuel fabrication data, (2) fuel irradiation data, (3) fission product monitoring system (FPMS) data, and (4) Advanced Test Reactor (ATR) operating conditions data. A final report giving the NDMAS qualification status of all AGR-1 data (including cycle 145A) is planned for February 2010.

  17. AGR-2 Data Qualification Interim Report

    SciTech Connect

    Michael L. Abbott

    2010-09-01

    Projects for the very high temperature reactor (VHTR) Technology Development Office program provide data in support of Nuclear Regulatory Commission licensing of the VHTR. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high temperature and high fluence environments. The VHTR program established the NGNP Data Management and Analysis System (NDMAS) to manage and document VHTR data qualification, for storage of the data in a readily accessible electronic form, and to assist in the analysis and presentation of the data. This document gives the status of NDMAS processing and qualification of data associated with the initial reactor cycle (147A) of the second Advanced Gas Reactor (AGR-2) experiment which began on June 21, 2010. Because it is early in the AGR-2 experiment, data from only two AGR-2 data streams are reported on: Fuel Fabrication and Fuel Irradiation data. As of August 1, 2010, approximately 311,000 irradiation data records have been stored in NDMAS, and qualification tests are in progress. Preliminary information indicates that TC 2 in Capsule 2 failed prior to start of the experiment, and NDMAS testing has thus far identified only two invalid data values from the METSO data collection system Data from the Fission Product Monitoring System (FPMS) are not currently processed until after reactor cycle shutdown and have not yet been received. A description of the ATR operating conditions data associated with the AGR-2 experiment (e.g., power levels) are summarized in the AGR-1 data qualification report (INL/EXT-09-16460). Since ATR data are collected under ATR program data quality requirements (i.e., outside the VHTR program), the NGNP program and NDMAS do not take additional actions to qualify these data other than NDMAS capture testing. Data qualification of graphite characterization data collected under the Graphite Technology Development Project is reported in a separate status report (Hull 2010).

  18. Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity

    PubMed Central

    Chen, Yi-Fong; Lin, Yi-Chien; Morris-Natschke, Susan L; Wei, Chen-Fang; Shen, Ting-Chen; Lin, Hui-Yi; Hsu, Mei-Hua; Chou, Li-Chen; Zhao, Yu; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau

    2015-01-01

    Background and Purpose 4-Phenylquinolin-2(1H)-one (4-PQ) derivatives can induce cancer cell apoptosis. Additional new 4-PQ analogs were investigated as more effective, less toxic antitumour agents. Experimental Approach Forty-five 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives were synthesized. Antiproliferative activities were evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliun bromide assay and structure–activity relationship correlations were established. Compounds 9b, 9c, 9e and 11e were also evaluated against the National Cancer Institute-60 human cancer cell line panel. Hoechst 33258 and Annexin V-FITC/PI staining assays were used to detect apoptosis, while inhibition of microtubule polymerization was assayed by fluorescence microscopy. Effects on the cell cycle were assessed by flow cytometry and on apoptosis-related proteins (active caspase-3, -8 and -9, procaspase-3, -8, -9, PARP, Bid, Bcl-xL and Bcl-2) by Western blotting. Key Results Nine 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives (7e, 8e, 9b, 9c, 9e, 10c, 10e, 11c and 11e) displayed high potency against HL-60, Hep3B, H460, and COLO 205 cancer cells (IC50 < 1 μM) without affecting Detroit 551 normal human cells (IC50 > 50 μM). Particularly, compound 11e exhibited nanomolar potency against COLO 205 cancer cells. Mechanistic studies indicated that compound 11e disrupted microtubule assembly and induced G2/M arrest, polyploidy and apoptosis via the intrinsic and extrinsic signalling pathways. Activation of JNK could play a role in TRAIL-induced COLO 205 apoptosis. Conclusion and Implications New quinolone derivatives were identified as potential pro-apoptotic agents. Compound 11e could be a promising lead compound for future antitumour agent development. PMID:25363404

  19. A Novel pseudo-Four-Component Domino Reaction for the Synthesis of Naphtho[2,1-b]furan-2(1H)-ones Using a Nanocatalyst.

    PubMed

    Salami-Ranjbaran, Elmira; Khosropour, Ahmad R; Mohammadpoor-Baltork, Iraj; Moghadam, Majid; Tangestaninejad, Shahram; Mirkhani, Valiollah

    2015-08-10

    In this article, an original one-pot method is utilized to synthesize a variety of derivatives of naphtho[2,1-b]furan-2(1H)-one via a pseudo-four-component domino reaction of aryl aldehydes, acetic anhydride, hippuric acids, and 2-naphthols catalyzed by HSW@SPIONs. This reaction illustrates an array of attractive features including, with particular interest in this report, a convenient and unique process of creating and utilizing a powerful recyclable nanocatalyst. PMID:26145510

  20. Syntheses of vanadyl and zinc(II) complexes of 1-hydroxy-4,5,6-substituted 2(1H)-pyrimidinones and their insulin-mimetic activities.

    PubMed

    Yamaguchi, Mika; Wakasugi, Kei; Saito, Ryota; Adachi, Yusuke; Yoshikawa, Yutaka; Sakurai, Hiromu; Katoh, Akira

    2006-02-01

    Control of the glucose level in the blood plasma has been achieved in vitro and in vivo by administration of vanadium and zinc in form of inorganic salts. It has been shown that elements are poorly absorbed in their inorganic forms and required high doses which have been associated with undesirable side effects. Many researchers, therefore, have focused on metal complexes that were prepared from VOSO(4) or ZnSO(4) and low-molecular-weight bidentate ligands. Seven kinds of 1-hydroxy-4,6-disubstituted and 1-hydroxy-4,5,6-trisubstituted-2(1H)-pyrimidinones were synthesized by reaction of N-benzyloxyurea and beta-diketones and subsequent removal of the protecting group. Six kinds of 1-hydroxy-4-(substituted)amino-2(1H)-pyrimidinones were synthesized by the substitution reaction of 1-benzyloxy-4-(1',2',4'-triazol-1'-yl)-2(1H)-pyrimidinone with various alkyl amines or amino acids. Treatment with VOSO(4) and ZnSO(4) or Zn(OAc)(2) afforded vanadyl(IV) and zinc(II) complexes which were characterized by means of (1)H NMR, IR, EPR, and UV-vis spectroscopies, and combustion analysis. The in vitro insulin-mimetic activity of these complexes was evaluated from 50% inhibitory concentrations (IC(50)) on free fatty acid (FFA) release from isolated rat adipocytes treated with epinephrine. Vanadyl complexes of 4,6-disubstituted-2(1H)-pyrimidinones showed higher insulin-mimetic activities than those of 4,5,6-trisubstituted ones. On the other hand, Zn(II) complexes showed lower insulin-mimetic activities than VOSO(4) and ZnSO(4) as positive controls. It was found that the balance of the hydrophilicity and/or hydrophobicity is important for higher insulin-mimetic activity. The in vivo insulin-mimetic activity was evaluated with streptozotocin (STZ)-induced diabetic rats. Blood glucose levels were lowered from hyperglycemic to normal levels after the treatment with bis(1,2-dihydro-4,6-dimethyl-2-oxo-1-pyrimidinolato)oxovanadium(IV) by daily intraperitoneal injections. The improvement in glucose tolerance was also confirmed by an oral glucose tolerance test. PMID:16387366

  1. Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potent d-Amino Acid Oxidase (DAAO) Inhibitors

    SciTech Connect

    Duplantier, Allen J.; Becker, Stacey L.; Bohanon, Michael J.; Borzilleri, Kris A.; Chrunyk, Boris A.; Downs, James T.; Hu, Lain-Yen; El-Kattan, Ayman; James, Larry C.; Liu, Shenping; Lu, Jiemin; Maklad, Noha; Mansour, Mahmoud N.; Mente, Scot; Piotrowski, Mary A.; Sakya, Subas M.; Sheehan, Susan; Steyn, Stefanus J.; Strick, Christine A.; Williams, Victoria A.; Zhang, Lei; Pfizer

    2010-09-27

    3-Hydroxyquinolin-2(1H)-one (2) was discovered by high throughput screening in a functional assay to be a potent inhibitor of human DAAO, and its binding affinity was confirmed in a Biacore assay. Cocrystallization of 2 with the human DAAO enzyme defined the binding site and guided the design of new analogues. The SAR, pharmacokinetics, brain exposure, and effects on cerebellum D-serine are described. Subsequent evaluation against the rat DAAO enzyme revealed a divergent SAR versus the human enzyme and may explain the high exposures of drug necessary to achieve significant changes in rat or mouse cerebellum D-serine.

  2. New Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Benzotriazolium-Based Ionic Liquids under Solvent-Free Conditions.

    PubMed

    Liu, Zhiqing; Ma, Rong; Cao, Dawei; Liu, Chenjiang

    2016-01-01

    An efficient synthesis of novel 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) and their derivatives, using Brønsted acidic ionic liquid [C₂O₂BBTA][TFA] as a catalyst, from the condensation of aryl aldehyde, β-ketoester and urea was described. Reactions proceeded smoothly for 40 min under solvent-free conditions and gave the desirable products with good to excellent yields (up to 99%). The catalyst could be easily recycled and reused with similar efficacies for at least six cycles. PMID:27070558

  3. The ASEAN economic community and medical qualification

    PubMed Central

    Kittrakulrat, Jathurong; Jongjatuporn, Witthawin; Jurjai, Ravipol; Jarupanich, Nicha; Pongpirul, Krit

    2014-01-01

    Background In the regional movement toward ASEAN Economic Community (AEC), medical professions including physicians can be qualified to practice medicine in another country. Ensuring comparable, excellent medical qualification systems is crucial but the availability and analysis of relevant information has been lacking. Objective This study had the following aims: 1) to comparatively analyze information on Medical Licensing Examinations (MLE) across ASEAN countries and 2) to assess stakeholders’ view on potential consequences of AEC on the medical profession from a Thai perspective. Design To search for relevant information on MLE, we started with each country's national body as the primary data source. In case of lack of available data, secondary data sources including official websites of medical universities, colleagues in international and national medical student organizations, and some other appropriate Internet sources were used. Feasibility and concerns about validity and reliability of these sources were discussed among investigators. Experts in the region invited through HealthSpace.Asia conducted the final data validation. For the second objective, in-depth interviews were conducted with 13 Thai stakeholders, purposely selected based on a maximum variation sampling technique to represent the points of view of the medical licensing authority, the medical profession, ethicists and economists. Results MLE systems exist in all ASEAN countries except Brunei, but vary greatly. Although the majority has a national MLE system, Singapore, Indonesia, and Vietnam accept results of MLE conducted at universities. Thailand adopted the USA's 3-step approach that aims to check pre-clinical knowledge, clinical knowledge, and clinical skills. Most countries, however, require only one step. A multiple choice question (MCQ) is the most commonly used method of assessment; a modified essay question (MEQ) is the next most common. Although both tests assess candidate

  4. DATA QUALIFICATION REPORT: MAJOR ION AND PH DATA FOR USE ON THE YUCCA MOUNTAIN PROJECT

    SciTech Connect

    C. WILSON; D.M. JENKINS; T. STEINBORN; R. WEMHEUER

    2000-08-23

    This data qualification report uses technical assessment and corroborating data methods according to Attachment 2 of AP-SIII.2Q, Rev. 0, ICN 2, ''Qualification of Unqualified Data and the Documentation of Rationale for Accepted Data'', to qualify major ion and pH data. This report was prepared in accordance with Data Qualification Plan TDP-NBS-GS-00003 1, Revision 2. Additional reports will be prepared to address isotopic and precipitation-related data. Most of the data considered in this report were acquired and developed by the U.S. Geological Survey (USGS). The data qualification team considers the sampling and analytical protocols employed by the USGS over the time period of data acquisition to be state-of-the-art. The sample collection methodologies have evolved with no significant change that could affect the quality of the data considered in this report into the currently used Hydrologic Procedures that support the Yucca Mountain Project-approved USGS Quality Assurance Program Plan. Consequently, for USGS data, the data collection methods, documentation, and results are reasonable and appropriate in view of standard practice at the time the data were collected. A small number of data sets were collected by organizations other than the USGS and were reviewed along with the other major ion and pH data using corroborating data methods. Hydrochemical studies reviewed in this qualification report indicate that the extent and quality of corroborating data are sufficient to support qualification of both USGS and non-USGS major ion and pH data for generalized hydrochemical studies. The corroborating data included other major ion and pH data, isotope data, and independent hydrological data. Additionally, the analytical adequacy of the major ion data was supported by a study of anion-cation charge balances. Charge balance errors for USGS and non-USGS data were under 10% and acceptable for all data. This qualification report addresses the specific major ion data sets

  5. New Zealand's Move to Graduate-Profile Framed Qualifications: Implications, Challenges and the Occupational Identity Solution

    ERIC Educational Resources Information Center

    Chan, Selena

    2016-01-01

    In 2008, the New Zealand Qualifications Authority (NZQA), responsible for the quality assurance of all qualifications, embarked on a review of all qualifications between Levels 1 and 6 on the 10-level National Qualifications Framework (NQF). The review process mandated the reviewed qualifications to be founded on outcome statements of graduate…

  6. Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1H)-one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists.

    PubMed

    Lingam, V S Prasadarao; Dahale, Dnyaneshwar H; Rathi, Vijay E; Shingote, Yogesh B; Thakur, Rajni R; Mindhe, Ajit S; Kummari, Srinivas; Khairatkar-Joshi, Neelima; Bajpai, Malini; Shah, Daisy M; Sapalya, Ratika S; Gullapalli, Srinivas; Gupta, Praveen K; Gudi, Girish S; Jadhav, Satyawan B; Pattem, Rambabu; Thomas, Abraham

    2015-10-22

    We report the design and synthesis of novel 5,6-diarylated pyridin-2(1H)-one derivatives as pharmacophoric PDE10A inhibitors. This highly potent molecular scaffold was developed from an inactive diarylpyridine-2-amine derivative 3b by extensive and systematic analogue synthesis and SAR analysis. Further optimization of the scaffold resulted in identification of pyridin-2(1H)-one 18b as a lead compound with good potency (IC50 = 1.6 nM) and selectivity (>6000-fold) over other related PDEs but with a poor pharmacokinetic profile. Careful metabolite profiling of 18b revealed that poor systemic exposure in rats (Cmax = 44 ng/mL; AUC0-t = 359 ng · h/mL) at 10 mg/kg was due to the formation of O-glucuronide conjugate by phase 2 metabolism. The structure of the glucuronide metabolite was confirmed by retention time and LC-MS/MS fragmentation matching with the synthetic glucuronide 26. The problem of low exposure of 18b was effectively addressed by its conversion to an acetate prodrug 25b, which upon oral dosing resulted in an improved pharmacokinetic profile (Cmax = 359 ng.h/mL; AUC0-t = 2436 ng.h/mL) and a desirable brain to plasma ratio of 1.2. The prodrug 25b showed good efficacy in selected rodent models of psychosis. PMID:26421921

  7. Potent Antifouling Marine Dihydroquinolin-2(1H)-one-Containing Alkaloids from the Gorgonian Coral-Derived Fungus Scopulariopsis sp.

    PubMed

    Shao, Chang-Lun; Xu, Ru-Fang; Wang, Chang-Yun; Qian, Pei-Yuan; Wang, Kai-Ling; Wei, Mei-Yan

    2015-08-01

    Marine biofouling has a major economic impact, especially when it occurs on ship hulls or aquaculture facilities. Since the International Maritime Organization (IMO) treaty to ban the application of organotin-based paints to ships went into effect in 2008, there is an urgent demand for the development of efficient and environmentally friendly antifouling agents. Marine microorganisms have proved to be a potential source of antifouling natural compounds. In this study, six dihydroquinolin-2-one-containing alkaloids, three monoterpenoids combined with a 4-phenyl-3,4-dihydroquinolin-2(1H)-one (1-3) and three 4-phenyl-3,4-dihydroquinolin-2(1H)-one alkaloids (4-6), were isolated from the gorgonian coral-derived fungus Scopulariopsis sp. collected in the South China Sea. These dihydroquinolin-2-one-containing alkaloids were evaluated against the larval settlement of barnacle Balanus amphitrite, and antifouling activity was detected for the first time for this class of metabolites. All of them except 6 showed strong antifouling activity. Compounds 1 and 2 were discovered to be the most promising non-toxic antilarval settlement candidates. Especially, compound 1 is the strongest antifouling compound in nature until now which showed highly potent activity with picomolar level (EC50 17.5 pM) and a very safety and high therapeutic ratio (LC50/EC50 1200). This represents an effective non-toxic, anti-larval settlement structural class of promising antifouling lead compound. PMID:25833409

  8. Sensor Data Qualification System (SDQS) Implementation Study

    NASA Technical Reports Server (NTRS)

    Wong, Edmond; Melcher, Kevin; Fulton, Christopher; Maul, William

    2009-01-01

    The Sensor Data Qualification System (SDQS) is being developed to provide a sensor fault detection capability for NASA s next-generation launch vehicles. In addition to traditional data qualification techniques (such as limit checks, rate-of-change checks and hardware redundancy checks), SDQS can provide augmented capability through additional techniques that exploit analytical redundancy relationships to enable faster and more sensitive sensor fault detection. This paper documents the results of a study that was conducted to determine the best approach for implementing a SDQS network configuration that spans multiple subsystems, similar to those that may be implemented on future vehicles. The best approach is defined as one that most minimizes computational resource requirements without impacting the detection of sensor failures.

  9. RERTR Fuel Developmemt and Qualification Plan

    SciTech Connect

    Dan Wachs

    2007-01-01

    In late 2003 it became evident that U-Mo aluminum fuels under development exhibited significant fuel performance problems under the irradiation conditions required for conversion of most high-powered research reactors. Solutions to the fuel performance issue have been proposed and show promise in early testing. Based on these results, a Reduced Enrichment Research and Test Reactor (RERTR) program strategy has been mapped to allow generic fuel qualification to occur prior to the end of FY10 and reactor conversion to occur prior to the end of FY14. This strategy utilizes a diversity of technologies, test conditions, and test types. Scoping studies using miniature fuel plates will be completed in the time frame of 2006-2008. Irradiation of larger specimens will occur in the Advanced Test Reactor (ATR) in the United States, the Belgian Reactor-2 (BR2) reactor in Belgium, and in the OSIRIS reactor in France in 2006-2009. These scoping irradiation tests provide a large amount of data on the performance of advanced fuel types under irradiation and allow the down selection of technology for larger scale testing during the final stages of fuel qualification. In conjunction with irradiation testing, fabrication processes must be developed and made available to commercial fabricators. The commercial fabrication infrastructure must also be upgraded to ensure a reliable low enriched uranium (LEU) fuel supply. Final qualification of fuels will occur in two phases. Phase I will obtain generic approval for use of dispersion fuels with density less than 8.5 g-U/cm3. In order to obtain this approval, a larger scale demonstration of fuel performance and fabrication technology will be necessary. Several Materials Test Reactor (MTR) plate-type fuel assemblies will be irradiated in both the High Flux Reactor (HFR) and the ATR (other options include the BR2 and Russian Research Reactor, Dmitrovgrad, Russia [MIR] reactors) in 2008-2009. Following postirradiation examination, a report

  10. Reaction wheel design, construction and qualification testing

    NASA Astrophysics Data System (ADS)

    Proper, Ian

    This thesis examines the design, construction, and space-qualification testing of a microsatellite class reaction wheel. A literature review compares both currently and formerly operational, as well as commercially available reaction wheel assemblies, to assess the torque and momentum generation capabilities relative to the masses of the respective units. Several potential software models for a prototype reaction wheel are constructed and compared to the units described in the literature review to determine feasibility of operation. Choosing a particular model, the prototype wheel is then constructed and baseline tests are performed to determine its operational characteristics. Finally, a series of qualification tests are performed: a life test, a vibration test and a thermal vacuum test. These tests aim to validate the ability of the prototype reaction wheel unit to operate for at least a six-month mission in a typical low Earth orbit environment.

  11. Historical flight qualifications of space nuclear systems

    SciTech Connect

    Bennett, G.L.

    1997-01-01

    An overview is presented of the qualification programs for the general-purpose heat source radioisotope thermoelectric generators (GPHS-RTGs) as developed for the Galileo and Ulysses missions; the SNAP-10A space reactor; the Nuclear Engine for Rocket Vehicle Applications (NERVA); the F-1 chemical rocket engine used on the Saturn-V Apollo lunar missions; and the Space Shuttle Main Engines (SSMEs). Some similarities and contrasts between the qualification testing employed on these five programs will be noted. One common thread was that in each of these successful programs there was an early focus on component and subsystem tests to uncover and correct problems. {copyright} {ital 1997 American Institute of Physics.}

  12. Qualification Approach for the CMC Nose Cap of X-38

    NASA Astrophysics Data System (ADS)

    Weihs, H.; Gülhan, A.

    2002-01-01

    given by the predicted re-entry loads. Discrete tests on smaller samples representing cut outs of the structure were performed for further qualification which could not be done at the complete assembly due to the limitations of the test facilities (e.g. plasma channel test). In addition to the qualification of the material or coating capability, arc jet tests were performed to check the steps and gaps influence and qualify sealing function at the interfaces between the CMC parts. This paper will give an overview of the thermal and mechanical qualification of the nose cap system. This includes the vibration loads, thermal cycling, mechanical pressure and steps and gaps arc jet tests.

  13. Qualification test and analysis report: Solar collectors

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Test results show that the Owens-Illinois Sunpak TM Model SEC 601 air-cooled collector meets the national standards and codes as defined in the Subsystem Peformance Specification and Verification Plan of NASA/MSFC, dated October 28, 1976. The program calls for the development, fabrication, qualification and delivery of an air-cooled solar collector for solar heating, combined heating and cooling, and/or hot water systems.

  14. High Temperature Materials Interim Data Qualification Report

    SciTech Connect

    Nancy Lybeck

    2010-08-01

    ABSTRACT Projects for the very high temperature reactor (VHTR) Technology Development Office provide data in support of Nuclear Regulatory Commission licensing of the VHTR. Fuel and materials to be used in the reactor are tested and characterized to quantify performance in high temperature and high fluence environments. The VHTR program has established the NGNP Data Management and Analysis System (NDMAS) to ensure that VHTR data are qualified for use, stored in a readily accessible electronic form, and analyzed to extract useful results. This document focuses on the first NDMAS objective. It describes the High Temperature Materials characterization data stream, the processing of these data within NDMAS, and reports the interim FY2010 qualification status of the data. Data qualification activities within NDMAS for specific types of data are determined by the data qualification category assigned by the data generator. The High Temperature Materials data are being collected under NQA-1 guidelines, and will be qualified data. For NQA-1 qualified data, the qualification activities include: (1) capture testing, to confirm that the data stored within NDMAS are identical to the raw data supplied, (2) accuracy testing to confirm that the data are an accurate representation of the system or object being measured, and (3) documenting that the data were collected under an NQA-1 or equivalent Quality Assurance program. Currently, data from two test series within the High Temperature Materials data stream have been entered into the NDMAS vault: 1. Tensile Tests for Sm (i.e., Allowable Stress) Confirmatory Testing – 1,403,994 records have been inserted into the NDMAS database. Capture testing is in process. 2. Creep-Fatigue Testing to Support Determination of Creep-Fatigue Interaction Diagram – 918,854 records have been processed and inserted into the NDMAS database. Capture testing is in process.

  15. Software qualification of selected TOUGH2 modules

    SciTech Connect

    Wu, Y.S.; Ahlers, C.F.; Fraser, P.; Simmons, A.; Pruess, K.

    1996-10-01

    The purpose of this package of reports is to provide all software baseline documents necessary for the software qualification of the single-phase Gas (EOS1G), Effective Continuum Method (ECM), Saturated/Unsaturated Flow (EOS9), and Radionuclide Transport (T2R3D) modules of TOUGH2, a numerical simulation code for multi-dimensional coupled fluid and heat flow of multiphase, multicomponent fluid mixtures in porous and fractured media. This report contains the following sections: (1) Requirements Specification, (2) Design Description, (3) Software Validation Test Plan and Report, (4) Software User Documentation, and (5) Appendices. These sections comprise sequential parts of the Software Life Cycle, and are not intended to stand alone but should be used in conjunction with the TOUGH User`s Guide (Pruess, 1987), TOUGH2--A General Purpose Numerical Simulator for Multiphase Fluid and Heat Flow (Pruess, 1991), and the above-referenced TOUGH2 software qualification document. The qualification package is complete with the attached Software Identification Form and executable source code for the single-phase Gas, Effective Continuum method, Saturated/Unsaturated Flow, and Radionuclide Transport modules of TOUGH2.

  16. Heat Treatment Procedure Qualification for Steel Castings

    SciTech Connect

    Mariol Charles; Nicholas Deskevich; Vipin Varkey; Robert Voigt; Angela Wollenburg

    2004-04-29

    Heat treatment practices used by steel foundries have been carefully studied as part of comprehensive heat treatment procedure qualification development trials. These studies highlight the relationships between critical heat treatment process control parameters and heat treatment success. Foundry heat treatment trials to develop heat treatment procedure qualifications have shed light on the relationship between heat treatment theory and current practices. Furnace load time-temperature profiles in steel foundries exhibit significant differences depending on heat treatment equipment, furnace loading practice, and furnace maintenance. Time-temperature profiles of furnace control thermocouples can be very different from the time-temperature profiles observed at the center of casting loads in the furnace. Typical austenitization temperatures and holding times used by steel foundries far exceed what is required for transformation to austenite. Quenching and hardenability concepts were also investigated. Heat treatment procedure qualification (HTPQ) schema to demonstrate heat treatment success and to pre-qualify other alloys and section sizes requiring lesser hardenability have been developed. Tempering success is dependent on both tempering time and temperature. As such, furnace temperature uniformity and control of furnace loading during tempering is critical to obtain the desired mechanical properties. The ramp-up time in the furnace prior to the establishment of steady state heat treatment conditions contributes to the extent of heat treatment performed. This influence of ramp-up to temperature during tempering has been quantified.

  17. Qualification of a computer program for drill string dynamics

    SciTech Connect

    Stone, C.M.; Carne, T.G.; Caskey, B.C.

    1985-01-01

    A four point plan for the qualification of the GEODYN drill string dynamics computer program is described. The qualification plan investigates both modal response and transient response of a short drill string subjected to simulated cutting loads applied through a polycrystalline diamond compact (PDC) bit. The experimentally based qualification shows that the analytical techniques included in Phase 1 GEODYN correctly simulate the dynamic response of the bit-drill string system. 6 refs., 8 figs.

  18. Evidence of Polymorphism on the Antitrypanosomal Naphthoquinone (4E)-2-(1H-Pyrazol-3-ylamino)-4-(1H-pyrazol-3-ylimino)naphthalen-1(4H)-one

    PubMed Central

    Sperandeo, Norma R.; Faudone, Sonia N.

    2013-01-01

    The aim of this study was to characterize the solid state properties of (4E)-2-(1H-pyrazol-3-ylamino)-4-(1H-pyrazol-3-ylimino)naphthalen-1(4H)-one (BiPNQ), a compound with a significant inhibitory activity against Trypanosoma cruzi, the etiological agent of Chagas disease (American trypanosomiasis). Methods used included Differential Scanning Calorimetry (DSC), Thermogravimetry (TG), Fourier Transform Infrared Spectroscopy (FTIR), Powder X-Ray Diffraction (PXRD), Hot Stage, and Confocal Microscopy. Two BiPNQ samples were obtained by crystallization from absolute methanol and 2-propanol-water that exhibited different thermal behaviours, PXRD patterns, and FTIR spectra, indicating the existence of an anhydrous form (BiPNQ-I) and a solvate (BIPNQ-s), which on heating desolvated leading to the anhydrous modification BiPNQ-I. It was determined that FTIR, DSC, and PXRD are useful techniques for the characterization and identification of the crystalline modifications of BiPNQ. PMID:24106678

  19. 34 CFR 200.55 - Qualifications of teachers.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Basic Programs Operated by Local Educational Agencies Qualifications of Teachers and Paraprofessionals..., history, and geography. (d) Private school teachers. The requirements in this section do not apply...

  20. Results of the PRDA 35 qualification tests of the Motorola concentrating photovoltaic module

    SciTech Connect

    Pritchard, D.A.

    1981-10-01

    A passively-cooled, Fresnel lens, concentrating photovoltaic module, designed and built by Motorola, Incorporated, was tested to the PRDA 35 specifications. The PRDA 35 module test program is described. Physical, electrical, and thermal characteristics of the module are presented. Module performance is shown using multiple linear regression techniques: some change was measured after environmental exposure. In addition, sample cell assemblies were evaluated for effects of severe environmental conditions. Results presented herein show the module has met the qualification goals.

  1. Effect of Teacher's Qualification on the Performance of Senior Secondary School Physics Students: Implication on Technology in Nigeria

    ERIC Educational Resources Information Center

    Owolabi, Olabode Thomas; Adedayo, Julius Olugbenga

    2012-01-01

    The study examined the effect of teacher's qualification on the performance of Senior Secondary School students in Physics. The purpose was to determine whether the status of the teacher has any impact on the performance of the students in Physics. The survey type of descriptive research design was adopted. The sample for the study consisted of…

  2. Qualification and Gender Dimensions in Attitude of Secondary School Social Studies Teachers towards Computer Usage in Kogi State Nigeria

    ERIC Educational Resources Information Center

    Achor, Emmanuel E.; Shaibu, Joshua S.

    2013-01-01

    This study examined attitude dimensions of secondary school social studies teachers towards computer usage in Kogi State Nigeria. Qualification and Gender influence on their use was examined. Participants were 427 (Male = 224; female = 203) social studies teachers. Sampling was purposive and random. The study adopted the survey design. Data were…

  3. Just the Ticket? The National Professional Qualification and the Transition to Headship in the East Midlands of England

    ERIC Educational Resources Information Center

    Rhodes, Christopher; Brundrett, Mark; Nevill, Alan

    2009-01-01

    This article seeks to explore the influence of the National Professional Qualification for Headship (NPQH) in England in supporting aspirant heads to make the transition to headship. It draws upon a sample of NPQH graduates confirming their perceived readiness for headship prior to the commencement of their NPQH programme. A questionnaire survey…

  4. 4,6-Dimeth­oxy­pyrimidin-2-amine–2-(1H-indol-3-yl)acetic acid (1/1)

    PubMed Central

    Ebenezer, Samuel; Muthiah, Packianathan Thomas

    2010-01-01

    In the title co-crystal C6H9N3O2·C10H9NO2, the 4,6-dimeth­oxy­pyrimidin-2-amine mol­ecule inter­acts with the carboxyl group of the 2-(1H-indol-3-yl)acetic acid mol­ecule through N—H⋯O and O—H⋯N hydrogen bonds, forming a cyclic hydrogen-bonded R 2 2(8) motif, which is further linked by an N—H⋯N hydrogen bond, forming a supra­molecular chain along the c axis. Neighboring chains are inter­linked via C—H⋯O hydrogen bonds, forming a supra­molecular ladder PMID:21587607

  5. 2-[(1H-Benzimidazol-2-ylmethyl)-amino]-benzoic acid methyl ester: Crystal structure, DFT calculations and biological activity evaluation

    NASA Astrophysics Data System (ADS)

    Ghani, Nour T. Abdel; Mansour, Ahmed M.

    2011-10-01

    In the present study, structural properties of 2-[(1H-benzimidazol-2-ylmethyl)-amino]-benzoic acid methyl ester have been studied extensively by spectral methods and X-ray crystallography. Quantum mechanical calculations of energies, geometries, vibrational wavenumbers, NMR and electronic transitions were carried out by DFT using B3LYP functional combined with 6-31G(d) basis set. Natural bond orbitals (NBO) analysis and frontier molecular orbitals were performed at the same level of theory. DFT calculations showed good agreement between the theoretical and experimental values of optimized and X-ray structure as well as between the vibrational and NMR spectroscopy. The title compound was screened for its antibacterial activity referring to Tetracycline as standard antibacterial agent.

  6. Host-guest interaction between 3,4-dihydroisoquinoline-2(1H)-sulfonamide and β-cyclodextrin: Spectroscopic and molecular modeling studies

    NASA Astrophysics Data System (ADS)

    Seridi, Saida; Seridi, Achour; Berredjem, Malika; Kadri, Mekki

    2013-11-01

    The inclusion complex of 3,4-dihydroisoquinoline-2(1H)-sulfonamide with β-cyclodextrin was investigated experimentally and by molecular modeling studies. The stoichiometric ratio of the complex was found to be 1:1 and the stability constant was evaluated using the Benesi-Hildebrand equation. Estimation of the thermodynamic parameters of the inclusion complex in vacuum showed that it is an enthalpy driven process phase and an enthalpy-entropy co-driven process in aqueous solution, which is in accord with the experimental results. Semi-empirical calculations using PM3, PM6 and ONIOM2 methods, in vacuum and in water, were performed. The energetically more favorable structure obtained with the ONIOM2 method leads to the formation of intermolecular hydrogen bonds between sulfonamide and β-cyclodextrin. These interactions were investigated using the Natural Bond Orbital (NBO).

  7. Plutonium(IV) and plutonium(VI) extraction by 1-hydroxy-6-N-octylcarboxamide-2-(1H)-pyridinone

    SciTech Connect

    Romanovski, V.V.; Hoffman, D.C. |; White, D.J.; Xu, J.; Raymond, K.N.

    1999-01-01

    Extraction of Pu(IV) and Pu(VI) from nitric acid media by the promising new extractant 1-hydroxy-6-N-octylcarboxamide-2(1H)-pyridinone (octyl-1,2-HOPO) has been investigated. The effects of nitric acid, sodium, aluminum and iron(III) nitrates on extraction have been examined. Octyl-1,2-HOPO exhibits high specificity for Pu(IV) over a wide range of acidity and ionic strength. The affinity of octyl-1,2-HOPO for Pu(VI) is much less than for Pu(IV). However, the extraction of Pu(VI) is possible from acidic as well as from highly salted media. Two water soluble ligands, 1-hydroxyethane-1,1,-diphosphonic acid (HEDPA) and H(2,2)-1,2-HOPO, have been shown to be very effective for back extraction.

  8. CB2-Selective Cannabinoid Receptor Ligands: Synthesis, Pharmacological Evaluation, and Molecular Modeling Investigation of 1,8-Naphthyridin-2(1H)-one-3-carboxamides

    PubMed Central

    2015-01-01

    We have recently identified 1,8-naphthyridin-2(1H)-one-3-carboxamide as a new scaffold very suitable for the development of new CB2 receptor potent and selective ligands. In this paper we describe a number of additional derivatives in which the same central scaffold has been variously functionalized in position 1 or 6. All new compounds showed high selectivity and affinity in the nanomolar range for the CB2 receptor. Furthermore, we found that their functional activity is controlled by the presence of the substituents at position C-6 of the naphthyridine scaffold. In fact, the introduction of substituents in this position determined a functionality switch from agonist to antagonists/inverse agonists. Finally, docking studies showed that the difference between the pharmacology of these ligands may be in the ability/inability to block the Toggle Switch W6.48(258) (χ1 g+ → trans) transition. PMID:25272206

  9. Design, synthesis and biological activities of novel oxazolo[4,5-g]quinazolin-2(1H)-one derivatives as EGFR inhibitors.

    PubMed

    Yin, Siyuan; Zhou, Liliang; Lin, Jinsheng; Xue, Lingjing; Zhang, Can

    2015-08-28

    A series of oxazolo[4,5-g]quinazolin-2(1H)-one derivatives employing Erlotinib as lead compound were synthesized and evaluated for their EGFR inhibition activity. These compounds having variation at the 1 and 8-position, included ether and esters hydrophilic side-chain and aromatic head fragment, respectively. All these compounds were evaluated by EGFR inhibition and two anti-proliferation assays in vitro. Four compounds were found more potent than Erlotinib in EGFR-TK assay. Furthermore, compounds 18, 42 and 50 also had good to excellent anti-proliferation activity against human epidermoid cancer cell line (KB) and renal cell carcinoma cell line (A498). Finally, compound 50 presented remarkably higher inhibition efficacy towards tumor growth than Erlotinib in a mouse lewis lung cancer (LLC) xenograft model. Furthermore, compound 50 displayed the most distinguished effect on extending the survival period of the tumor-bearing mice. PMID:26188620

  10. The novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of N-aryl urea: synthesis, anti-inflammatory, antibacterial and antifungal activity evaluation.

    PubMed

    Tale, Rajesh H; Rodge, Atish H; Hatnapure, Girish D; Keche, Ashish P

    2011-08-01

    A series of novel 3,4-dihydropyrimidin-2(1H)-one urea derivatives of biological interest were prepared by sequential Bigineli's reaction, reduction followed by reaction of resulting amines with different arylisocynates. All the synthesized (1-23) compounds were screened against the pro-inflammatory cytokines (TNF-α and IL-6) and antimicrobial activity (antibacterial and antifungal). Biological activity evaluation study reveled that among all the compounds screened, compounds 12 and 17 found to have promising anti-inflammatory activity (68-62% TNF-α and 92-86% IL-6 inhibitory activity at 10 μM). Interestingly compounds 3, 4, 5, 6, 15, 22 and 23 revealed promising antimicrobial activity at MIC of 10-30 μg/mL against selected pathogenic bacteria and fungi. PMID:21737269

  11. Lightning arrestor connector lead magnesium niobate qualification pellet test procedures.

    SciTech Connect

    Tuohig, W.; Mahoney, Patrick A.; Tuttle, Bruce Andrew; Wheeler, Jill Susanne

    2009-02-01

    Enhanced knowledge preservation for DOE DP technical component activities has recently received much attention. As part of this recent knowledge preservation effort, improved documentation of the sample preparation and electrical testing procedures for lead magnesium niobate--lead titanate (PMN/PT) qualification pellets was completed. The qualification pellets are fabricated from the same parent powders used to produce PMN/PT lightning arrestor connector (LAC) granules at HWF&T. In our report, the procedures for fired pellet surface preparation, electrode deposition, electrical testing and data recording are described. The dielectric measurements described in our report are an information only test. Technical reasons for selecting the electrode material, electrode size and geometry are presented. The electrical testing is based on measuring the dielectric constant and dissipation factor of the pellet during cooling from 280 C to 220 C. The most important data are the temperature for which the peak dielectric constant occurs (Curie Point temperature) and the peak dielectric constant magnitude. We determined that the peak dielectric constant for our procedure would be that measured at 1 kHz at the Curie Point. Both the peak dielectric constant and the Curie point parameters provide semi-quantitative information concerning the chemical and microstructural homogeneity of the parent material used for the production of PMN/PT granules for LACs. Finally, we have proposed flag limits for the dielectric data for the pellets. Specifically, if the temperature of the peak dielectric constant falls outside the range of 250 C {+-} 30 C we propose that a flag limit be imposed that will initiate communication between production agency and design agency personnel. If the peak dielectric constant measured falls outside the range 25,000 {+-} 10,000 we also propose that a flag limit be imposed.

  12. SLUDGE BATCH 7B QUALIFICATION ACTIVITIES WITH SRS TANK FARM SLUDGE

    SciTech Connect

    Pareizs, J.; Click, D.; Lambert, D.; Reboul, S.

    2011-11-16

    Waste Solidification Engineering (WSE) has requested that characterization and a radioactive demonstration of the next batch of sludge slurry - Sludge Batch 7b (SB7b) - be completed in the Shielded Cells Facility of the Savannah River National Laboratory (SRNL) via a Technical Task Request (TTR). This characterization and demonstration, or sludge batch qualification process, is required prior to transfer of the sludge from Tank 51 to the Defense Waste Processing Facility (DWPF) feed tank (Tank 40). The current WSE practice is to prepare sludge batches in Tank 51 by transferring sludge from other tanks. Discharges of nuclear materials from H Canyon are often added to Tank 51 during sludge batch preparation. The sludge is washed and transferred to Tank 40, the current DWPF feed tank. Prior to transfer of Tank 51 to Tank 40, SRNL typically simulates the Tank Farm and DWPF processes with a Tank 51 sample (referred to as the qualification sample). With the tight schedule constraints for SB7b and the potential need for caustic addition to allow for an acceptable glass processing window, the qualification for SB7b was approached differently than past batches. For SB7b, SRNL prepared a Tank 51 and a Tank 40 sample for qualification. SRNL did not receive the qualification sample from Tank 51 nor did it simulate all of the Tank Farm washing and decanting operations. Instead, SRNL prepared a Tank 51 SB7b sample from samples of Tank 7 and Tank 51, along with a wash solution to adjust the supernatant composition to the final SB7b Tank 51 Tank Farm projections. SRNL then prepared a sample to represent SB7b in Tank 40 by combining portions of the SRNL-prepared Tank 51 SB7b sample and a Tank 40 Sludge Batch 7a (SB7a) sample. The blended sample was 71% Tank 40 (SB7a) and 29% Tank 7/Tank 51 on an insoluble solids basis. This sample is referred to as the SB7b Qualification Sample. The blend represented the highest projected Tank 40 heel (as of May 25, 2011), and thus, the highest

  13. Test report: Electron-proton spectrometer qualification test unit, qualification test

    NASA Technical Reports Server (NTRS)

    Vincent, D. L.

    1972-01-01

    Qualification tests of the electron-proton spectrometer test unit are presented. The tests conducted were: (1) functional, (2) thermal/vacuum, (3) electromagnetic interference, (4) acoustic, (5) shock, (6) vibration, and (7) humidity. Results of each type of test are presented in the form of data sheets.

  14. Large Bore Powder Gun Qualification (U)

    SciTech Connect

    Rabern, Donald A.; Valdiviez, Robert

    2012-04-02

    A Large Bore Powder Gun (LBPG) is being designed to enable experimentalists to characterize material behavior outside the capabilities of the NNSS JASPER and LANL TA-55 PF-4 guns. The combination of these three guns will create a capability to conduct impact experiments over a wide range of pressures and shock profiles. The Large Bore Powder Gun will be fielded at the Nevada National Security Site (NNSS) U1a Complex. The Complex is nearly 1000 ft below ground with dedicated drifts for testing, instrumentation, and post-shot entombment. To ensure the reliability, safety, and performance of the LBPG, a qualification plan has been established and documented here. Requirements for the LBPG have been established and documented in WE-14-TR-0065 U A, Large Bore Powder Gun Customer Requirements. The document includes the requirements for the physics experiments, the gun and confinement systems, and operations at NNSS. A detailed description of the requirements is established in that document and is referred to and quoted throughout this document. Two Gun and Confinement Systems will be fielded. The Prototype Gun will be used primarily to characterize the gun and confinement performance and be the primary platform for qualification actions. This gun will also be used to investigate and qualify target and diagnostic modifications through the life of the program (U1a.104 Drift). An identical gun, the Physics Gun, will be fielded for confirmatory and Pu experiments (U1a.102D Drift). Both guns will be qualified for operation. The Gun and Confinement System design will be qualified through analysis, inspection, and testing using the Prototype Gun for the majority of process. The Physics Gun will be qualified through inspection and a limited number of qualification tests to ensure performance and behavior equivalent to the Prototype gun. Figure 1.1 shows the partial configuration of U1a and the locations of the Prototype and Physics Gun/Confinement Systems.

  15. X-38 Full Scale TPS Flight Qualification

    NASA Astrophysics Data System (ADS)

    Hilfer, G.

    2002-01-01

    The X-38 of NASA which is an experimental vehicle to prove crucial technologies of a future Crew Return Vehicle (CRV) for the International Space Station (ISS) will be equipped with a large number of newly developed components and systems. In particular, the thermal protection system of the most severely loaded surface areas such as the nose cap and the control surfaces represent a promising approach with respect to thermal endurance and re-usability aspects. The foremost nose section, the body flaps and a wing leading edge segment are all made from SiC-based fiber ceramics. Moreover, the body flap is an entire hot structure. The Nose Skirt Assembly and the Body Flap were developed and manufactured by German industry (MAN Technologie, DLR and ASTRIUM) within the frame of the national TETRA program. The Leading Edge Unit was developed and manufactured by MAN Technologie within the ESA-ARTP. As another effort within the TETRA program aimed at extending the national competence range, IABG developed and built a high-temperature test facility enabling full-scale flight qualification of thermal protection components. The main purpose of this facility was to allow application of all relevant load categories encountered during re-entry flight, i.e. thermal, mechanical and oxidative loads. The facility is in service since April 1999. Within the scope of the X-38 qualification tests the flexibility of the test facility could be demonstrated. Three full scale thermal protection components of X-38 which were very different in size, shape and test requirements were successfully flight qualified in the years 1999 - 2001. For all of the three components, namely the Leading Edge Unit, the Nose Skirt Assembly and the Body Flap, the time- dependent and locally variable temperature profiles of the re-entry flight had to be simulated in order to verify the structural integrity under thermal loads. Within these tests a superposition of the thermal loads with oxidative loads, with the

  16. Qualification of HiMAT flight systems

    NASA Technical Reports Server (NTRS)

    Myers, A. F.; Sheets, S. G.

    1980-01-01

    The highly maneuverable aircraft technology (HiMAT) remotely piloted research vehicle is discussed with emphasis on the advanced composite and metallic structures, digital fly-by-wire controls, and digitally implemented integrated propulsion control systems. Techniques used to qualify the systems for flight are examined. Computation and simulation of the HiMAT system are investigated in relation to Cyber-Varian simulation. The techniques used in flight qualification are complicated by ground based flight critical systems and severe onboard volume constraints imposed by the scale design.

  17. A Software System for Inspection Qualification

    NASA Astrophysics Data System (ADS)

    McNab, D.; McNab, A.; Leggat, P.; Robinson, R.; McDonald, J.

    2004-02-01

    In safety critical and non-routine situations, inspection capability may need to be demonstrated by an independent process of Inspection Qualification (IQ). This process is costly and time consuming. Therefore an approach that could aid in its production would be beneficial. This paper describes the development of interactive software tools empowering the NDT engineer to design and evaluate the capability of an ultrasonic inspection within a single environment. This paper discusses the motivation for the system, the design and implementation of the tools and the benefits it will provide.

  18. Qualification procedures for VHSIC/VLSI

    NASA Astrophysics Data System (ADS)

    Baumes, Thomas A.

    1990-12-01

    This program developed, outlined, refined, and verified the test methodology and qualification criteria and procedures to be used to ensure the integrity and reliability of microcircuit devices designed for insertion into military systems. A major portion of the criteria and procedures, reflected herein, enables a significant reduction in time and cost of the microcircuit Quality/Reliability Assurance process by addressing up front simulations during design prior to commitment, complex and expensive manufacturing processes with in-line quality processes controlled by a SPC (Statistical Process Control) program and ongoing QA Program using their TRB (Technology Review Board) and SEC (Standard Evaluation Circuit) programs.

  19. 24 CFR 3286.307 - Process for obtaining trainer's qualification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Process for obtaining trainer's...-Administered States § 3286.307 Process for obtaining trainer's qualification. (a) Where to apply. An applicant for qualification as a trainer must provide the applicant's legal name, address, and telephone...

  20. 5 CFR 351.702 - Qualifications for assignment.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 5 Administrative Personnel 1 2012-01-01 2012-01-01 false Qualifications for assignment. 351.702 Section 351.702 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS REDUCTION IN FORCE Assignment Rights (Bump and Retreat) § 351.702 Qualifications for assignment. (a) Except as provided in § 351.703, an employee...

  1. 49 CFR 214.343 - Training and qualification, general.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Training and qualification, general. 214.343 Section 214.343 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD WORKPLACE SAFETY Roadway Worker Protection § 214.343 Training and qualification, general. (a)...

  2. Qualification Plus: Performance and Durability Tests Beyond IEC 61215 (Presentation)

    SciTech Connect

    Kurtz, S.; Jordan, J.; Kempe, M.; Miller, D.; Bosco, N.; Silverman, T.; Hacke, P.; Phillips, N.; Earnest, T.; Romero, R.

    2014-03-01

    Qualification Plus is an accelerated test protocol and quality management system that gives higher confidence in field performance of PV modules compared with conventional qualification testing. The test sequences are being developed as consensus standards, but the early publication of these tests enables the community to begin benefiting from them sooner.

  3. Qualifications Frameworks in Europe: Forging the Right Links. Briefing Note

    ERIC Educational Resources Information Center

    Cedefop - European Centre for the Development of Vocational Training, 2013

    2013-01-01

    As national qualifications frameworks in Europe move closer to operation, policy integration becomes a key challenge. Introducing qualifications frameworks based on learning outcomes is now a global phenomenon. According to the recent joint publication by Cedefop, ETF and Unesco, frameworks are either established or being developed in 142…

  4. International Co-operation with Higher Vocational Qualifications: An Example.

    ERIC Educational Resources Information Center

    Imrie, Bradford W.

    An initiative was undertaken to develop cooperation with higher vocational qualifications between two "new" universities that were formerly polytechnics: City University of Hong Kong (CUHK) and the University of Northumbria at Newcastle (UNN) in England. The higher vocational qualifications were the Higher Diploma (HD) from CUHK and the Higher…

  5. AP-102/104 Retrieval control system qualification test procedure

    SciTech Connect

    RIECK, C.A.

    1999-05-18

    This Qualification Test Procedure documents the results of the qualification testing that was performed on the Project W-211, ''Initial Tank Retrieval Systems,'' retrieval control system (RCS) for tanks 241-AP-102 and 241-AP-104. The results confirm that the RCS has been programmed correctly and that the two related hardware enclosures have been assembled in accordance with the design documents.

  6. The European Qualification Framework: Skills, Competences or Knowledge?

    ERIC Educational Resources Information Center

    Mehaut, Philippe; Winch, Christopher

    2012-01-01

    The European Qualification Framework (EQF) is intended to transform European national qualification frameworks (NQFs) by moulding them into a learning outcomes framework. Currently adopted as an enabling law by the European Union, the EQF has now operated for several years. In order to secure widespread adoption, however, it will be necessary for…

  7. 14 CFR 60.7 - Sponsor qualification requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Sponsor qualification requirements. 60.7 Section 60.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  8. 14 CFR 60.7 - Sponsor qualification requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Sponsor qualification requirements. 60.7 Section 60.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  9. Training and Qualifications (Teachers and Workers for the Deaf).

    ERIC Educational Resources Information Center

    World Federation of the Deaf, Rome (Italy).

    Three papers consider the training and qualifications of teachers and workers for the deaf. H. Okopinski describes "Training Teachers for Deaf Children's Schools in Poland" and A. F. Mackenzie defines "The Qualifications of Workers for the Adult Deaf" in the United Kingdom. E. S. Levine reports on New York University's "Center for Research and…

  10. Limits to Mobility: Competence and Qualifications in Europe

    ERIC Educational Resources Information Center

    Le Deist, Francoise; Tutlys, Vidmantas

    2012-01-01

    Purpose: This paper aims to explore structural and systemic influences in the development of competence models and qualifications systems at sectoral and national levels across Europe, considering the influences of different socio-economic models of skill formation on the processes of design and provision of qualifications.…

  11. 49 CFR 396.25 - Qualifications of brake inspectors.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false Qualifications of brake inspectors. 396.25 Section..., REPAIR, AND MAINTENANCE § 396.25 Qualifications of brake inspectors. (a) Motor carriers and intermodal equipment providers must ensure that all inspections, maintenance, repairs or service to the brakes of...

  12. 43 CFR 2547.1 - Qualifications of applicants.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Qualifications of applicants. 2547.1 Section 2547.1 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND MANAGEMENT, DEPARTMENT OF THE INTERIOR LAND RESOURCE MANAGEMENT (2000) COLOR-OF-TITLE AND OMITTED LANDS Omitted Lands: General § 2547.1 Qualifications...

  13. Qualification Paths of Adult Educators in Sweden and Denmark

    ERIC Educational Resources Information Center

    Andersson, Per; Kopsen, Susanne; Larson, Anne; Milana, Marcella

    2013-01-01

    The qualification of adult educators is a central aspect of the quality of adult education. However, within current policy discourses and adult education research on the professional development of prospective adult educators, little attention is paid to teacher qualification when compared to other fields of education and training. In this study,…

  14. 32 CFR 935.139 - Motor vehicle operator qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Motor vehicle operator qualifications. 935.139... AND INSULAR REGULATIONS WAKE ISLAND CODE Motor Vehicle Code § 935.139 Motor vehicle operator qualifications. (a) No person may operate a privately owned motor vehicle on Wake Island unless he has an...

  15. 32 CFR 935.139 - Motor vehicle operator qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Motor vehicle operator qualifications. 935.139... AND INSULAR REGULATIONS WAKE ISLAND CODE Motor Vehicle Code § 935.139 Motor vehicle operator qualifications. (a) No person may operate a privately owned motor vehicle on Wake Island unless he has an...

  16. 32 CFR 935.139 - Motor vehicle operator qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 32 National Defense 6 2013-07-01 2013-07-01 false Motor vehicle operator qualifications. 935.139... AND INSULAR REGULATIONS WAKE ISLAND CODE Motor Vehicle Code § 935.139 Motor vehicle operator qualifications. (a) No person may operate a privately owned motor vehicle on Wake Island unless he has an...

  17. 32 CFR 935.139 - Motor vehicle operator qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 32 National Defense 6 2014-07-01 2014-07-01 false Motor vehicle operator qualifications. 935.139... AND INSULAR REGULATIONS WAKE ISLAND CODE Motor Vehicle Code § 935.139 Motor vehicle operator qualifications. (a) No person may operate a privately owned motor vehicle on Wake Island unless he has an...

  18. 32 CFR 935.139 - Motor vehicle operator qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 6 2012-07-01 2012-07-01 false Motor vehicle operator qualifications. 935.139... AND INSULAR REGULATIONS WAKE ISLAND CODE Motor Vehicle Code § 935.139 Motor vehicle operator qualifications. (a) No person may operate a privately owned motor vehicle on Wake Island unless he has an...

  19. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 42 Public Health 5 2011-10-01 2011-10-01 false Standard; laboratory director qualifications. 493...; laboratory director qualifications. The laboratory director must be qualified to manage and direct the... laboratory director must possess a current license as a laboratory director issued by the State in which...

  20. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 42 Public Health 5 2014-10-01 2014-10-01 false Standard; laboratory director qualifications. 493...; laboratory director qualifications. The laboratory director must be qualified to manage and direct the... laboratory director must possess a current license as a laboratory director issued by the State in which...

  1. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 42 Public Health 5 2012-10-01 2012-10-01 false Standard; laboratory director qualifications. 493...; laboratory director qualifications. The laboratory director must be qualified to manage and direct the... laboratory director must possess a current license as a laboratory director issued by the State in which...

  2. 42 CFR 493.1357 - Standard; laboratory director qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 42 Public Health 5 2013-10-01 2013-10-01 false Standard; laboratory director qualifications. 493...; laboratory director qualifications. The laboratory director must be qualified to manage and direct the... laboratory director must possess a current license as a laboratory director issued by the State in which...

  3. 49 CFR 1544.411 - Continuing qualifications of screening personnel.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Continuing qualifications of screening personnel... Screening § 1544.411 Continuing qualifications of screening personnel. (a) Impairment. No individual may perform a screening function if he or she shows evidence of impairment, such as impairment due to...

  4. 49 CFR 178.33b-7 - Design qualification test.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Design qualification test. 178.33b-7 Section 178... Specifications for Inside Containers, and Linings § 178.33b-7 Design qualification test. (a) Drop testing. (1) To ensure that creep does not affect the ability of the container to retain the contents, each new...

  5. Desirable Qualifications for Personnel Conducting Educational Program Evaluations and Audits.

    ERIC Educational Resources Information Center

    Newman, Warren B.

    A study was made of professional qualifications for personnel employed as program evaluators and auditors. These qualifications, according to operational or theoretical models, are necessary to assure local school districts of obtaining the services of competent and ethical personnel. Findings of (1) a review of literature, (2) a national survey…

  6. 17 CFR 1.16 - Qualifications and reports of accountants.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Qualifications and reports of accountants. 1.16 Section 1.16 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Minimum Financial and Related Reporting Requirements § 1.16 Qualifications and reports...

  7. 17 CFR 1.16 - Qualifications and reports of accountants.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Qualifications and reports of accountants. 1.16 Section 1.16 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Minimum Financial and Related Reporting Requirements § 1.16 Qualifications and reports...

  8. 17 CFR 1.16 - Qualifications and reports of accountants.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false Qualifications and reports of accountants. 1.16 Section 1.16 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Minimum Financial and Related Reporting Requirements § 1.16 Qualifications and reports...

  9. 17 CFR 1.16 - Qualifications and reports of accountants.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 1 2014-04-01 2014-04-01 false Qualifications and reports of accountants. 1.16 Section 1.16 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Minimum Financial and Related Reporting Requirements § 1.16 Qualifications and reports...

  10. 49 CFR 180.507 - Qualification of tank cars.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Qualification of tank cars. 180.507 Section 180.507 Transportation Other Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS CONTINUING QUALIFICATION AND MAINTENANCE OF PACKAGINGS...

  11. 49 CFR 178.33b-7 - Design qualification test.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Design qualification test. 178.33b-7 Section 178... PACKAGINGS Specifications for Inside Containers, and Linings § 178.33b-7 Design qualification test. (a) Drop..., each new design must be drop tested as follows: Three groups of twenty-five filled containers must...

  12. 47 CFR 54.409 - Consumer qualification for Lifeline.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 3 2014-10-01 2014-10-01 false Consumer qualification for Lifeline. 54.409... (CONTINUED) UNIVERSAL SERVICE Universal Service Support for Low-Income Consumers § 54.409 Consumer qualification for Lifeline. (a) To constitute a qualifying low-income consumer: (1) A consumer's...

  13. 47 CFR 54.409 - Consumer qualification for Lifeline.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 3 2012-10-01 2012-10-01 false Consumer qualification for Lifeline. 54.409... (CONTINUED) UNIVERSAL SERVICE Universal Service Support for Low-Income Consumers § 54.409 Consumer qualification for Lifeline. (a) To constitute a qualifying low-income consumer: (1) A consumer's...

  14. 47 CFR 54.409 - Consumer qualification for Lifeline.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 3 2013-10-01 2013-10-01 false Consumer qualification for Lifeline. 54.409... (CONTINUED) UNIVERSAL SERVICE Universal Service Support for Low-Income Consumers § 54.409 Consumer qualification for Lifeline. (a) To constitute a qualifying low-income consumer: (1) A consumer's...

  15. Qualifications Frameworks and Their Conflicting Social Imaginaries of Globalisation

    ERIC Educational Resources Information Center

    Louise Sarauw, Laura

    2012-01-01

    Critics often see the European Bologna Process as a univocal standardisation of higher education. By exploring how different qualifications frameworks project different social imaginaries of globalisation, this article takes a different stance. The overarching qualifications framework of the Bologna Process rests on a socially constituted and…

  16. 14 CFR 121.453 - Flight engineer qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... airplane unless, within the preceding 6 calendar months, he has had at least 50 hours of flight time as a... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Flight engineer qualifications. 121.453... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Crewmember Qualifications § 121.453 Flight...

  17. 14 CFR 121.453 - Flight engineer qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... airplane unless, within the preceding 6 calendar months, he has had at least 50 hours of flight time as a... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Flight engineer qualifications. 121.453... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Crewmember Qualifications § 121.453 Flight...

  18. 14 CFR 121.453 - Flight engineer qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... airplane unless, within the preceding 6 calendar months, he has had at least 50 hours of flight time as a... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Flight engineer qualifications. 121.453... REQUIREMENTS: DOMESTIC, FLAG, AND SUPPLEMENTAL OPERATIONS Crewmember Qualifications § 121.453 Flight...

  19. 48 CFR 34.103 - Testing and qualification.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Testing and qualification. 34.103 Section 34.103 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SPECIAL CATEGORIES OF CONTRACTING MAJOR SYSTEM ACQUISITION Testing, Qualification and Use of Industrial Resources Developed Under Title III,...

  20. Qualifications Frameworks: Expanding Influence, Persisting Obstacles. Briefing Note

    ERIC Educational Resources Information Center

    Cedefop - European Centre for the Development of Vocational Training, 2014

    2014-01-01

    Initial work on the European qualifications framework (EQF) started in autumn 2004. Partly triggered by this initiative, qualifications frameworks have since become integral parts of almost all education and training systems in Europe. Outside Europe, more and more countries and regions (such as Asia-Pacific) are rapidly developing and…

  1. The European Medicines Agency experience with biomarker qualification.

    PubMed

    Manolis, Efthymios; Koch, Armin; Deforce, Dieter; Vamvakas, Spiros

    2015-01-01

    Since the launch of the qualification process in 2009, the CHMP reviewed/is reviewing 48 requests for qualification advice or opinion (as of Sept 2013) related to biomarkers (BM) or other novel drug development tools (e.g. patient reported outcome measures, modeling, and statistical methods). The qualification opinions are available on the EMA website (Qualification of novel methodologies for medicine development, http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000319.jsp&mid=WC0b01ac0580022bb0#section2 , 2013). Also there is a trend of increasing numbers of qualification requests to CHMP, indicative of the pace that targeted drug development and personalized medicine is gaining and the need to bring the new tools from research to drug development and clinical use. This chapter will focus on the regulatory experience gained so far from the CHMP qualification procedure. Basic qualification principles will be presented. Through qualification examples, we will elaborate on common grounds and divergences between the different stakeholders. PMID:25384751

  2. 14 CFR 60.4 - Qualification Performance Standards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Qualification Performance Standards. 60.4 Section 60.4 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  3. 14 CFR 60.7 - Sponsor qualification requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Sponsor qualification requirements. 60.7 Section 60.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  4. 14 CFR 60.4 - Qualification Performance Standards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Qualification Performance Standards. 60.4 Section 60.4 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  5. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  6. 14 CFR 60.7 - Sponsor qualification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Sponsor qualification requirements. 60.7 Section 60.7 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  7. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 2 2011-01-01 2011-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  8. 49 CFR 639.11 - Lease qualification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 7 2010-10-01 2010-10-01 false Lease qualification requirements. 639.11 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION CAPITAL LEASES Requirements § 639.11 Lease qualification requirements. (a) A lease may qualify for capital assistance if it meets the following criteria: (1)...

  9. 23 CFR 650.309 - Qualifications of personnel.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 23 Highways 1 2012-04-01 2012-04-01 false Qualifications of personnel. 650.309 Section 650.309 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS National Bridge Inspection Standards § 650.309 Qualifications of personnel. (a) A program manager must, at...

  10. 23 CFR 650.309 - Qualifications of personnel.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Qualifications of personnel. 650.309 Section 650.309 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS National Bridge Inspection Standards § 650.309 Qualifications of personnel. (a) A program manager must, at...

  11. 30 CFR 75.155 - Qualified hoisting engineer; qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-hoisting engineer; or (2) If a State has no program for qualifying persons as electric-hoisting engineers... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Qualified hoisting engineer; qualifications. 75... Persons § 75.155 Qualified hoisting engineer; qualifications. (a)(1) A person is a qualified...

  12. 30 CFR 75.155 - Qualified hoisting engineer; qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-hoisting engineer; or (2) If a State has no program for qualifying persons as electric-hoisting engineers... 30 Mineral Resources 1 2014-07-01 2014-07-01 false Qualified hoisting engineer; qualifications. 75... Persons § 75.155 Qualified hoisting engineer; qualifications. (a)(1) A person is a qualified...

  13. 30 CFR 75.155 - Qualified hoisting engineer; qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-hoisting engineer; or (2) If a State has no program for qualifying persons as electric-hoisting engineers... 30 Mineral Resources 1 2012-07-01 2012-07-01 false Qualified hoisting engineer; qualifications. 75... Persons § 75.155 Qualified hoisting engineer; qualifications. (a)(1) A person is a qualified...

  14. 30 CFR 75.155 - Qualified hoisting engineer; qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-hoisting engineer; or (2) If a State has no program for qualifying persons as electric-hoisting engineers... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Qualified hoisting engineer; qualifications. 75... Persons § 75.155 Qualified hoisting engineer; qualifications. (a)(1) A person is a qualified...

  15. Examining the Impact of Entry Level Qualifications on Educational Aspirations

    ERIC Educational Resources Information Center

    Benton, Tom

    2014-01-01

    Background: This article considers the impact of pupils studying for entry-level qualifications on their intentions of remaining in education. Such qualifications are intended to re-engage young people who are performing below expected levels and give them the opportunity to learn at a pace that suits them. Purpose: This article specifically…

  16. 45 CFR 1306.21 - Staff qualification requirements.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Staff qualification requirements. 1306.21 Section 1306.21 Public Welfare Regulations Relating to Public Welfare (Continued) OFFICE OF HUMAN DEVELOPMENT... Requirements § 1306.21 Staff qualification requirements. Head Start programs must comply with section 648A...

  17. 7 CFR 400.206 - Financial qualifications for acceptability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Financial qualifications for acceptability. 400.206... Contract-Standards for Approval § 400.206 Financial qualifications for acceptability. The financial statement of an entity must show total allowable assets in excess of liabilities and the ability of...

  18. 32 CFR 935.69 - Qualifications and admission to practice.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Qualifications and admission to practice. 935.69 Section 935.69 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE TERRITORIAL AND INSULAR REGULATIONS WAKE ISLAND CODE Judiciary § 935.69 Qualifications and admission to practice. (a) No person may be appointed a...

  19. 32 CFR 935.69 - Qualifications and admission to practice.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 6 2011-07-01 2011-07-01 false Qualifications and admission to practice. 935.69 Section 935.69 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE TERRITORIAL AND INSULAR REGULATIONS WAKE ISLAND CODE Judiciary § 935.69 Qualifications and admission to practice. (a) No person may be appointed a...

  20. 42 CFR 493.1417 - Standard; Clinical consultant qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... qualifications. The clinical consultant must be qualified to consult with and render opinions to the laboratory's... 42 Public Health 5 2010-10-01 2010-10-01 false Standard; Clinical consultant qualifications. 493... HUMAN SERVICES (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Personnel for...

  1. Transferability of Distance-Education-Qualifications. ZIFF Papiere 107.

    ERIC Educational Resources Information Center

    Grochtmann, Ulrich; Kraft-Dittmar, Alice; Sander, Martin

    This document examines the transferability of distance learning qualifications within the 16 member states of the European Union and 18 Eastern European countries. Chapter 1 explains the document's structure, and chapter 2 presents basic information about the legal background regulating the recognition of academic and vocational qualifications in…

  2. Qualification Users' Perceptions and Experiences of Assessment Reliability

    ERIC Educational Resources Information Center

    Chamberlain, Suzanne

    2013-01-01

    This paper presents the findings of a study designed to explore qualification users' perceptions and experiences of reliability in the context of national assessment outcomes in England. The study consisted of 17 focus groups conducted across six sectors of qualification users: students, teachers, trainee teachers, job-seekers, employers and…

  3. Qualification and Lessons Learned with Space Flight Fiber Optic Components

    NASA Technical Reports Server (NTRS)

    Ott, Melanie

    2007-01-01

    This presentation covers lessons learned during the design, development, manufacturing and qualification of space flight fiber optic components. Changes at NASA, including short-term projects and decreased budgets have brought about changes to vendors and parts. Most photonics for NASA needs are now commercial off the shelf (COTS) products. The COTS Tecnology Assurance approach for space flight and qualification plans are outlined.

  4. Regional Foods and Rural Development: The Role of Product Qualification

    ERIC Educational Resources Information Center

    Tregear, Angela; Arfini, Filippo; Belletti, Giovanni; Marescotti, Andrea

    2007-01-01

    Qualification schemes have become popular tools for supporting regional foods, yet little is understood about the impacts they have on the rural development contribution of such foods. Qualification processes may stimulate new networks and community actions, but they may also be incompatible with strategies of extended territorial development…

  5. 32 CFR 571.2 - Basic qualifications for enlistment.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Basic qualifications for enlistment. 571.2 Section 571.2 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY PERSONNEL RECRUITING AND ENLISTMENTS Recruiting and Enlistment Eligibility § 571.2 Basic qualifications for enlistment. (a) Age requirements for non-prior service...

  6. 49 CFR 180.351 - Qualification of IBCs.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Qualification and Maintenance of IBCs § 180.351 Qualification of IBCs. (a) General. Each IBC used for the transportation of hazardous materials must be an authorized packaging. (b) IBC specifications. To qualify as an authorized packaging, each IBC must conform to this subpart, the applicable requirements specified in...

  7. 49 CFR 1546.405 - Qualifications of screening personnel.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 9 2014-10-01 2014-10-01 false Qualifications of screening personnel. 1546.405 Section 1546.405 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY FOREIGN AIR CARRIER SECURITY Screener Qualifications When...

  8. 46 CFR 68.37 - Cessation of qualifications.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... DOCUMENTATION OF VESSELS: EXCEPTIONS TO COASTWISE QUALIFICATION Documentation of Certain Vessels for Oil Spill Cleanup § 68.37 Cessation of qualifications. (a) If the vessel is owned by a not-for-profit oil spill... change. The not-for-profit oil spill response cooperative shall report the change in writing to...

  9. 46 CFR 68.37 - Cessation of qualifications.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... DOCUMENTATION OF VESSELS: EXCEPTIONS TO COASTWISE QUALIFICATION Documentation of Certain Vessels for Oil Spill Cleanup § 68.37 Cessation of qualifications. (a) If the vessel is owned by a not-for-profit oil spill... change. The not-for-profit oil spill response cooperative shall report the change in writing to...

  10. 46 CFR 68.37 - Cessation of qualifications.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... DOCUMENTATION OF VESSELS: EXCEPTIONS TO COASTWISE QUALIFICATION Documentation of Certain Vessels for Oil Spill Cleanup § 68.37 Cessation of qualifications. (a) If the vessel is owned by a not-for-profit oil spill... change. The not-for-profit oil spill response cooperative shall report the change in writing to...

  11. 48 CFR 1252.237-70 - Qualifications of contractor employees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... notify the contracting officer when an employee no longer requires access to DOT computer systems due to....237-70 Qualifications of contractor employees. As prescribed in (TAR) 48 CFR 1237.110(a), insert the... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Qualifications...

  12. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 2 2012-01-01 2012-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  13. 14 CFR 60.4 - Qualification Performance Standards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Qualification Performance Standards. 60.4 Section 60.4 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  14. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  15. 14 CFR 60.15 - Initial qualification requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 2 2014-01-01 2014-01-01 false Initial qualification requirements. 60.15 Section 60.15 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  16. 14 CFR 60.4 - Qualification Performance Standards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 2 2013-01-01 2013-01-01 false Qualification Performance Standards. 60.4 Section 60.4 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRMEN FLIGHT SIMULATION TRAINING DEVICE INITIAL AND CONTINUING QUALIFICATION AND USE §...

  17. 24 CFR 92.254 - Qualification as affordable housing: Homeownership.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Qualification as affordable housing: Homeownership. 92.254 Section 92.254 Housing and Urban Development Office of the Secretary, Department of Housing and Urban Development HOME INVESTMENT PARTNERSHIPS PROGRAM Project Requirements § 92.254 Qualification as affordable...

  18. 14 CFR 121.439 - Pilot qualification: Recent experience.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Pilot qualification: Recent experience. 121... Pilot qualification: Recent experience. (a) No certificate holder may use any person nor may any person serve as a required pilot flight crewmember, unless within the preceding 90 days, that person has...

  19. 14 CFR 125.281 - Pilot-in-command qualifications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Pilot-in-command qualifications. 125.281... Requirements § 125.281 Pilot-in-command qualifications. No certificate holder may use any person, nor may any person serve, as pilot in command of an airplane unless that person— (a) Holds at least a...

  20. 14 CFR 121.437 - Pilot qualification: Certificates required.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pilot qualification: Certificates required... Pilot qualification: Certificates required. (a) No pilot may act as pilot in command of an aircraft (or... pilots) unless he holds an airline transport pilot certificate and an appropriate type rating for...

  1. 14 CFR 121.437 - Pilot qualification: Certificates required.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 14 Aeronautics and Space 3 2011-01-01 2011-01-01 false Pilot qualification: Certificates required... Pilot qualification: Certificates required. (a) No pilot may act as pilot in command of an aircraft (or... pilots) unless he holds an airline transport pilot certificate and an appropriate type rating for...

  2. 14 CFR 125.281 - Pilot-in-command qualifications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Pilot-in-command qualifications. 125.281... Requirements § 125.281 Pilot-in-command qualifications. No certificate holder may use any person, nor may any person serve, as pilot in command of an airplane unless that person— (a) Holds at least a...

  3. 49 CFR 178.33b-7 - Design qualification test.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 3 2011-10-01 2011-10-01 false Design qualification test. 178.33b-7 Section 178... Specifications for Inside Containers, and Linings § 178.33b-7 Design qualification test. (a) Drop testing. (1) To ensure that creep does not affect the ability of the container to retain the contents, each new...

  4. 28 CFR 540.45 - Qualification as special visitor.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Qualification as special visitor. 540.45... CONTACT WITH PERSONS IN THE COMMUNITY Visiting Regulations § 540.45 Qualification as special visitor. Persons in the categories listed in this section may qualify as special visitors rather than as...

  5. 28 CFR 540.45 - Qualification as special visitor.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 2 2014-07-01 2014-07-01 false Qualification as special visitor. 540.45... CONTACT WITH PERSONS IN THE COMMUNITY Visiting Regulations § 540.45 Qualification as special visitor. Persons in the categories listed in this section may qualify as special visitors rather than as...

  6. 33 CFR 135.213 - Qualification as self-insurer.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Qualification as self-insurer... FUND Financial Responsibility for Offshore Facilities § 135.213 Qualification as self-insurer. (a... than which might be damaged as a result of a pollution incident, are available which may be...

  7. 12 CFR 231.3 - Qualification as a financial institution.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Qualification as a financial institution. 231.3... RESERVE SYSTEM NETTING ELIGIBILITY FOR FINANCIAL INSTITUTION (REGULATION EE) § 231.3 Qualification as a financial institution. (a) A person qualifies as a financial institution for purposes of sections 401-407...

  8. 24 CFR 92.254 - Qualification as affordable housing: Homeownership.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... application under 24 CFR part 597 has incorporated the type of market data described above, that submission... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Qualification as affordable housing... Qualification as affordable housing: Homeownership. (a) Acquisition with or without rehabilitation. Housing...

  9. 33 CFR 135.213 - Qualification as self-insurer.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Qualification as self-insurer... FUND Financial Responsibility for Offshore Facilities § 135.213 Qualification as self-insurer. (a... than which might be damaged as a result of a pollution incident, are available which may be...

  10. 28 CFR 540.45 - Qualification as special visitor.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Qualification as special visitor. 540.45... CONTACT WITH PERSONS IN THE COMMUNITY Visiting Regulations § 540.45 Qualification as special visitor. Persons in the categories listed in this section may qualify as special visitors rather than as...

  11. 12 CFR 231.3 - Qualification as a financial institution.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Qualification as a financial institution. 231.3... Qualification as a financial institution. (a) A person qualifies as a financial institution for purposes of... contracts as a counterparty on both sides of one or more financial markets and either— (1) Had one or...

  12. 33 CFR 135.213 - Qualification as self-insurer.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Qualification as self-insurer... FUND Financial Responsibility for Offshore Facilities § 135.213 Qualification as self-insurer. (a... than which might be damaged as a result of a pollution incident, are available which may be...

  13. 33 CFR 135.213 - Qualification as self-insurer.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Qualification as self-insurer... FUND Financial Responsibility for Offshore Facilities § 135.213 Qualification as self-insurer. (a... than which might be damaged as a result of a pollution incident, are available which may be...

  14. 28 CFR 540.45 - Qualification as special visitor.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Qualification as special visitor. 540.45... CONTACT WITH PERSONS IN THE COMMUNITY Visiting Regulations § 540.45 Qualification as special visitor. Persons in the categories listed in this section may qualify as special visitors rather than as...

  15. 33 CFR 135.213 - Qualification as self-insurer.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Qualification as self-insurer... FUND Financial Responsibility for Offshore Facilities § 135.213 Qualification as self-insurer. (a... than which might be damaged as a result of a pollution incident, are available which may be...

  16. 28 CFR 540.45 - Qualification as special visitor.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Qualification as special visitor. 540.45... CONTACT WITH PERSONS IN THE COMMUNITY Visiting Regulations § 540.45 Qualification as special visitor. Persons in the categories listed in this section may qualify as special visitors rather than as...

  17. The Hidden Potential of Level 5 Qualifications. Briefing Note

    ERIC Educational Resources Information Center

    Cedefop - European Centre for the Development of Vocational Training, 2014

    2014-01-01

    European qualifications framework (EQF) levels reveal what a learner knows, understands, and can do at the end of a learning experience. Thanks to the comprehensive nature of the EQF, these learning outcomes can also provide policy-makers with a fine mesh of data about each particular level and every kind of qualification. Nowhere is this mesh…

  18. 30 CFR 880.11 - Qualifications of projects.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 30 Mineral Resources 3 2011-07-01 2011-07-01 false Qualifications of projects. 880.11 Section 880.11 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION MINE FIRE CONTROL § 880.11 Qualifications of projects. The purpose of...

  19. 30 CFR 880.11 - Qualifications of projects.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Qualifications of projects. 880.11 Section 880.11 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR ABANDONED MINE LAND RECLAMATION MINE FIRE CONTROL § 880.11 Qualifications of projects. The purpose of...

  20. 46 CFR 57.01-1 - Qualifications and production tests.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Qualifications and production tests. 57.01-1 Section 57.01-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING WELDING AND BRAZING Scope § 57.01-1 Qualifications and production tests. (a) (Replaces QW 101 and QB 101.)...

  1. 49 CFR 1546.405 - Qualifications of screening personnel.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 9 2012-10-01 2012-10-01 false Qualifications of screening personnel. 1546.405 Section 1546.405 Transportation Other Regulations Relating to Transportation (Continued) TRANSPORTATION SECURITY ADMINISTRATION, DEPARTMENT OF HOMELAND SECURITY CIVIL AVIATION SECURITY FOREIGN AIR CARRIER SECURITY Screener Qualifications When...

  2. 41 CFR 51-4.3 - Maintaining qualification.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Maintaining qualification. 51-4.3 Section 51-4.3 Public Contracts and Property Management Other Provisions Relating to Public Contracts COMMITTEE FOR PURCHASE FROM PEOPLE WHO ARE BLIND OR SEVERELY DISABLED 4-NONPROFIT AGENCIES § 51-4.3 Maintaining qualification. (a)...

  3. The Malaysian Qualifications Framework. An Institutional Response to Intrinsic Weaknesses

    ERIC Educational Resources Information Center

    Keating, Jack

    2011-01-01

    This article discusses the Malaysian Qualifications Framework (MQF). An observation about the MQF is that in the particular context of developments in Malaysian education and training and its economic and social context, all roads have led to standards and quality assurance. This is the view expressed by the Malaysian Qualifications Agency (MQA)…

  4. 49 CFR 396.25 - Qualifications of brake inspectors.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 5 2012-10-01 2012-10-01 false Qualifications of brake inspectors. 396.25 Section..., REPAIR, AND MAINTENANCE § 396.25 Qualifications of brake inspectors. (a) Motor carriers and intermodal equipment providers must ensure that all inspections, maintenance, repairs or service to the brakes of...

  5. 49 CFR 396.25 - Qualifications of brake inspectors.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 5 2013-10-01 2013-10-01 false Qualifications of brake inspectors. 396.25 Section..., REPAIR, AND MAINTENANCE § 396.25 Qualifications of brake inspectors. (a) Motor carriers and intermodal equipment providers must ensure that all inspections, maintenance, repairs or service to the brakes of...

  6. 49 CFR 396.25 - Qualifications of brake inspectors.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 5 2011-10-01 2011-10-01 false Qualifications of brake inspectors. 396.25 Section..., REPAIR, AND MAINTENANCE § 396.25 Qualifications of brake inspectors. (a) Motor carriers and intermodal equipment providers must ensure that all inspections, maintenance, repairs or service to the brakes of...

  7. 49 CFR 396.25 - Qualifications of brake inspectors.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 5 2014-10-01 2014-10-01 false Qualifications of brake inspectors. 396.25 Section..., REPAIR, AND MAINTENANCE § 396.25 Qualifications of brake inspectors. (a) Motor carriers and intermodal equipment providers must ensure that all inspections, maintenance, repairs or service to the brakes of...

  8. 30 CFR 281.4 - Qualifications of lessees.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Qualifications of lessees. 281.4 Section 281.4 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR OFFSHORE LEASING OF MINERALS OTHER THAN OIL, GAS, AND SULPHUR IN THE OUTER CONTINENTAL SHELF General § 281.4 Qualifications...

  9. 5 CFR 317.502 - Qualifications Review Board certification.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATIONS EMPLOYMENT IN THE SENIOR EXECUTIVE SERVICE Career Appointments § 317.502 Qualifications Review.../managerial qualifications of a candidate before initial career appointment may be made to an SES position. More than one-half of the members of a QRB must be SES career appointees. (b) Agency requests...

  10. 5 CFR 317.502 - Qualifications Review Board certification.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGULATIONS EMPLOYMENT IN THE SENIOR EXECUTIVE SERVICE Career Appointments § 317.502 Qualifications Review.../managerial qualifications of a candidate before initial career appointment may be made to an SES position. More than one-half of the members of a QRB must be SES career appointees. (b) Agency requests...

  11. Qualifications for Tenure: The Legal Definitions. ASHE Annual Meeting Paper.

    ERIC Educational Resources Information Center

    Lee, Barbara A.

    The issue of qualifications for tenure is examined with attention to judicial tests for qualification in lawsuits in which faculty alleged that negative tenure decisions were infected with illegal discrimination. The focus is the degree to which a faculty plaintiff must demonstrate at the first stage of the lawsuit that he or she was qualified for…

  12. 46 CFR 402.210 - Requirements and qualifications for registration.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 8 2010-10-01 2010-10-01 false Requirements and qualifications for registration. 402.210 Section 402.210 Shipping COAST GUARD (GREAT LAKES PILOTAGE), DEPARTMENT OF HOMELAND SECURITY GREAT LAKES PILOTAGE RULES AND ORDERS Registration of Pilots § 402.210 Requirements and qualifications for registration. (a) Pursuant to §...

  13. BSM Delta Qualification 2, volume 2

    NASA Astrophysics Data System (ADS)

    1994-11-01

    This report, presented in three volumes, provides the results of a two-motor Delta Qualification 2 program conducted in 1993 to certify the following enhancements for incorporation into booster separation motor (BSM) flight hardware: vulcanized-in-place nozzle aft closure insulation; new iso-static ATJ bulk graphite throat insert material; adhesive EA 9394 for bonding the nozzle throat, igniter grain rod/centering insert/igniter case; deletion of the igniter adapter insulator ring; deletion of the igniter adapter/igniter case interface RTV; and deletion of loctite from igniter retainer plate threads. The enhancements above directly resulted from (1) the BSM total quality management (TQM) team initiatives to enhance the BSM producibility, and (2) the necessity to qualify new throat insert and adhesive systems to replace existing materials that will not be available. Testing was completed at both the component and motor levels. Component testing was accomplished to screen candidate materials (e.g., throat materials, adhesive systems) and to optimize processes (e.g., aft closure insulator vulcanization approach) prior to their incorporation into the test motors. Motor tests -- consisting of two motors, randomly selected by USBI's on-site quality personnel from production lot AAY, which were modified to accept the enhancements -- were completed to provide the final qualification of the enhancements for incorporation into flight hardware. Volume 2 details the environmental testing (vibration and shock) conducted at Marshall Space Flight Center (MSFC) to which the motors were subjected prior to static tests.

  14. Qualification tests for 192Ir sealed sources

    NASA Astrophysics Data System (ADS)

    Iancso, Georgeta; Iliescu, Elena; Iancu, Rodica

    2013-12-01

    This paper describes the results of qualification tests for 192Ir sealed sources, available in Testing and Nuclear Expertise Laboratory of National Institute for Physics and Nuclear Engineering "Horia Hulubei" (I.F.I.N.-HH), Romania. These sources had to be produced in I.F.I.N.-HH and were tested in order to obtain the authorization from The National Commission for Nuclear Activities Control (CNCAN). The sources are used for gammagraphy procedures or in gammadefectoscopy equipments. Tests, measurement methods and equipments used, comply with CNCAN, AIEA and International Quality Standards and regulations. The qualification tests are: 1. Radiological tests and measurements: dose equivalent rate at 1 m; tightness; dose equivalent rate at the surface of the transport and storage container; external unfixed contamination of the container surface. 2. Mechanical and climatic tests: thermal shock; external pressure; mechanic shock; vibrations; boring; thermal conditions for storage and transportation. Passing all tests, it was obtained the Radiological Security Authorization for producing the 192Ir sealed sources. Now IFIN-HH can meet many demands for this sealed sources, as the only manufacturer in Romania.

  15. BSM Delta qualification 2, volume 1

    NASA Astrophysics Data System (ADS)

    1994-11-01

    This report, presented in three volumes, provides the results of a two-motor Delta Qualification 2 program conducted in 1993 to certify the following enhancements for incorporation into Booster Separation Motor (BSM) flight hardware: (1) vulcanized-in-place nozzle aft closure insulation; (2) new isostatic ATJ bulk graphite throat insert material; (3) adhesive EA 9394 for bonding the nozzle throat, igniter grain rod/centering insert/igniter case; (4) deletion of the igniter adapter insulator ring; (5) deletion of igniter adapter/igniter case interface RTV; and (6) deletion of Loctite from igniter retainer plate threads. The enhancements above directly resulted from (1) the BSM Total Quality Management (TQM) Team initiatives to enhance the BSM producibility, and (2) the necessity to qualify new throat insert and adhesive systems to replace existing materials that will not be available. Testing was completed at both the component and motor levels. Component testing was accomplished to screen candidate materials (e.g., throat materials, adhesive systems) and to optimize processes (e.g., aft closure insulator vulcanization approach) prior to their incorporation into the test motors. Motor testing - consisting of two motors, randomly selected by USBI's onsite quality personnel from production lot AAY, which were modified to accept the enhancements - were completed to provide the final qualification of the enhancements for incorporation into flight hardware. It is concluded that all of the enhancements herein tested are qualified to be incorporated into flight hardware for the BSM.

  16. Guide for Oxygen Component Qualification Tests

    NASA Technical Reports Server (NTRS)

    Bamford, Larry J.; Rucker, Michelle A.; Dobbin, Douglas

    1996-01-01

    Although oxygen is a chemically stable element, it is not shock sensitive, will not decompose, and is not flammable. Oxygen use therefore carries a risk that should never be overlooked, because oxygen is a strong oxidizer that vigorously supports combustion. Safety is of primary concern in oxygen service. To promote safety in oxygen systems, the flammability of materials used in them should be analyzed. At the NASA White Sands Test Facility (WSTF), we have performed configurational tests of components specifically engineered for oxygen service. These tests follow a detailed WSTF oxygen hazards analysis. The stated objective of the tests was to provide performance test data for customer use as part of a qualification plan for a particular component in a particular configuration, and under worst-case conditions. In this document - the 'Guide for Oxygen Component Qualification Tests' - we outline recommended test systems, and cleaning, handling, and test procedures that address worst-case conditions. It should be noted that test results apply specifically to: manual valves, remotely operated valves, check valves, relief valves, filters, regulators, flexible hoses, and intensifiers. Component systems are not covered.

  17. [Hypoxic training of high qualification sportsmen].

    PubMed

    Radziievs'kiĭ, P O; Radziievs'ka, M P

    2003-01-01

    Normobaric intermittent hypoxic training (IHT) is an effective method for improving of of the functional respiration system (FRS) state, increase of aerobic productivity, general and special capacity for work in sportsmen of high qualification. The advantage of the use of intermittent hypoxic training during the preparation of high qualification sportsmen is so that hypoxic hypoxia and hypoxia of load influence on the sportsman organism in different time (IHT is doing during the rest, out of the planned sport training without the influence on it). This is a difference with the hypoxic training in mountain conditions where two types of hypoxia influence on the sportsman organism simultaneously and permanently--hypoxia of load and hypoxic hypoxia, and additive destructive action of the both types of hypoxia may be revealed. High efficacy of intermittent hypoxic training in improving of all parts of sportsmen FRS is a result alternating of hypoxic influences and normoxic intervals between them during which the level of plastic processes remains increased, oxygen tension in arterial blood and tissues increases to normoxic values. After IHT course, the state of respiration organs improves, the respiration volume, part of alveolar ventilation in the minute volume of respiration, saturation of arterial blood by oxygen, haemoglobin content in blood--increase as well as increase economy and efficacy of oxygen regimes of organism, general and special (especially important) physical capacity for work increase too. PMID:12918261

  18. BSM Delta qualification 2, volume 1

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This report, presented in three volumes, provides the results of a two-motor Delta Qualification 2 program conducted in 1993 to certify the following enhancements for incorporation into Booster Separation Motor (BSM) flight hardware: (1) vulcanized-in-place nozzle aft closure insulation; (2) new isostatic ATJ bulk graphite throat insert material; (3) adhesive EA 9394 for bonding the nozzle throat, igniter grain rod/centering insert/igniter case; (4) deletion of the igniter adapter insulator ring; (5) deletion of igniter adapter/igniter case interface RTV; and (6) deletion of Loctite from igniter retainer plate threads. The enhancements above directly resulted from (1) the BSM Total Quality Management (TQM) Team initiatives to enhance the BSM producibility, and (2) the necessity to qualify new throat insert and adhesive systems to replace existing materials that will not be available. Testing was completed at both the component and motor levels. Component testing was accomplished to screen candidate materials (e.g., throat materials, adhesive systems) and to optimize processes (e.g., aft closure insulator vulcanization approach) prior to their incorporation into the test motors. Motor testing - consisting of two motors, randomly selected by USBI's onsite quality personnel from production lot AAY, which were modified to accept the enhancements - were completed to provide the final qualification of the enhancements for incorporation into flight hardware. It is concluded that all of the enhancements herein tested are qualified to be incorporated into flight hardware for the BSM.

  19. BSM Delta Qualification 2, volume 2

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This report, presented in three volumes, provides the results of a two-motor Delta Qualification 2 program conducted in 1993 to certify the following enhancements for incorporation into booster separation motor (BSM) flight hardware: vulcanized-in-place nozzle aft closure insulation; new iso-static ATJ bulk graphite throat insert material; adhesive EA 9394 for bonding the nozzle throat, igniter grain rod/centering insert/igniter case; deletion of the igniter adapter insulator ring; deletion of the igniter adapter/igniter case interface RTV; and deletion of loctite from igniter retainer plate threads. The enhancements above directly resulted from (1) the BSM total quality management (TQM) team initiatives to enhance the BSM producibility, and (2) the necessity to qualify new throat insert and adhesive systems to replace existing materials that will not be available. Testing was completed at both the component and motor levels. Component testing was accomplished to screen candidate materials (e.g., throat materials, adhesive systems) and to optimize processes (e.g., aft closure insulator vulcanization approach) prior to their incorporation into the test motors. Motor tests -- consisting of two motors, randomly selected by USBI's on-site quality personnel from production lot AAY, which were modified to accept the enhancements -- were completed to provide the final qualification of the enhancements for incorporation into flight hardware. Volume 2 details the environmental testing (vibration and shock) conducted at Marshall Space Flight Center (MSFC) to which the motors were subjected prior to static tests.

  20. Heat Treatment Procedure Qualification -- Final Technical Report

    SciTech Connect

    Robert C. Voigt

    2004-10-15

    Heat treatment practices used by steel foundries have been carefully studied as part of comprehensive heat treatment procedure development trials. These studies highlight the relationships between critical heat treatment process control parameters and heat treatment success. Foundry heat treatment trials to develop heat treatment procedure qualification have shed light on the relationship between heat treatment theory and current practices. Furnace load time-temperature profiles in steel foundries exhibit significant differences depending on heat treatment equipment, furnace loading practice, and furnace maintenance. Time-temperature profiles of the furnace control thermocouples can be very different from the time-temperature profiles observed at the center of casting loads in the furnace. Typical austenitrization temperatures and holding times used by steel foundries far exceed what is required for transformation to austenite. Quenching and hardenability concepts were also investigated. Heat treatment procedure qualification (HTPQ) schema to demonstrate heat treatment success and to pre-qualify other alloys and section sizes requiring lesser hardenability have been developed. Tempering success is dependent on both tempering time and temperature. As such, furnace temperature uniformity and control of furnace loading during tempering is critical to obtain the desired mechanical properties. The ramp-up time in the furnace prior to the establishment of steady state heat treatment conditions contributes to the extent of heat treatment performed. This influence of ramp-up to temperature during tempering has been quantified.

  1. Sludge Washing And Demonstration Of The DWPF Flowsheet In The SRNL Shielded Cells For Sludge Batch 8 Qualification

    SciTech Connect

    Pareizs, J. M.; Crawford, C. L.

    2013-04-26

    The current Waste Solidification Engineering (WSE) practice is to prepare sludge batches in Tank 51 by transferring sludge from other tanks to Tank 51. Tank 51 sludge is washed and transferred to Tank 40, the current Defense Waste Processing Facility (DWPF) feed tank. Prior to transfer of Tank 51 to Tank 40, the Savannah River National Laboratory (SRNL) typically simulates the Tank Farm and DWPF processes using a Tank 51 sample (referred to as the qualification sample). WSE requested the SRNL to perform characterization on a Sludge Batch 8 (SB8) sample and demonstrate the DWPF flowsheet in the SRNL shielded cells for SB8 as the final qualification process required prior to SB8 transfer from Tank 51 to Tank 40. A 3-L sample from Tank 51 (the SB8 qualification sample; Tank Farm sample HTF-51-12-80) was received by SRNL on September 20, 2012. The as-received sample was characterized prior to being washed. The washed material was further characterized and used as the material for the DWPF process simulation including a Sludge Receipt and Adjustment Tank (SRAT) cycle, a Slurry Mix Evaporator (SME) cycle, and glass fabrication and chemical durability measurements.

  2. Development and qualification of an antibody rapid deglycosylation method.

    PubMed

    Cook, K Steven; Bullock, Kevin; Sullivan, Timothy

    2012-03-01

    N-linked glycosylation can influence the biological activity and safety of an antibody as well as be a measure of the consistency of the production process. The released N-glycans is an important part of the development of a therapeutic antibody. The traditional method for N-glycan analysis requires complex and laborious sample preparation and lengthy analysis time. Two preparation steps with limited control are removal of the antibody backbone by ice-cold ethanol precipitation and water removal before 2-AB fluorescent dye labeling. Simplification of the sample preparation and better control of key steps that allows for the characterization/quantitation of glycans during all stages of development of a therapeutic antibody is desired. Recently Prozyme introduced a rapid deglycosylation kit and a rapid tagging kit that address some of these issues. The deglycosylation kit immobilizes the antibody on a membrane, thereby eliminating the precipitation step. An instant fluorescent tag kit eliminates the water removal before the 2-AB labeling step. In addition use of a new chromatography column can improve the glycan resolution and shorten the analysis time. The evaluation and qualification of the Rapid Deglycosylation Kit (RDK) and instant 2-AB tagging with the improved chromatography are highlighted. PMID:22257749

  3. X-ray and DFT calculated structures of 2-(1 H-imidazol-1-yl)-1-(2-naphthyl)ethan-1-one N-phenylthiosemicarbazone and 2-(1 H-imidazol-1-yl)-1-(2-naphthyl)ethan-1-one N-(4-chlorophenyl)thiosemicarbazone

    NASA Astrophysics Data System (ADS)

    Sahin, Z. S.; Septioglu, E.; Calis, U.; Isik, S.

    2014-12-01

    Crystal and molecular structures of two new compounds 2-(1 H-imidazol-1-yl)-1-(2-naphthyl)ethan-1-one N-phenylthiosemicarbazone, C22H19N5S, ( I) and 2-(1 H-imidazol-1-yl)-1-(2-naphthyl)ethan-1-one N-(4-chlorophenyl)thiosemicarbazone, C22H18ClN5S, ( II) have been determined by single-crystal X-ray diffraction. Molecular geometries from X-ray experiment of I and II have been compared with those calculated using the Density Functional Theory (DFT) with B3LYP/6-31G( d, p) basis set. Both compounds crystallize in the monoclinic space group P21/ c with Z = 4: a = 13.2880(5), 14.2648(3) Å, b = 9.4122(2), 9.3892(3) Å, c = 15.6341(6), 15.6268(4) Å, β = 101.779(3)°, 104.926(2)°, for I and II, respectively. An extensive two-dimensional network of N-H⋯N hydrogen bonds and π-ring interactions are responsible for crystal stabilization in both structures.

  4. Transformation of Learning in Education and Training: Key Qualifications Revisited. CEDEFOP Reference Series.

    ERIC Educational Resources Information Center

    Kamarainen, Pekka, Ed.; Attwell, Graham, Ed.; Brown, Alan, Ed.

    This book contains 15 papers examining European approaches to the theme of key qualifications. The following papers are included: "Key Qualifications Revisited: An Introduction" (Pekka Kamarainen); "Exploring Key Qualifications: Context, Theory, and Practice in Europe" (Pekka Kamarainen); "Rethinking Key Qualifications: Towards a New Framework"…

  5. Minimum qualifications for clinical pharmacy practice faculty.

    PubMed

    Engle, Janet P; Erstad, Brian L; Anderson, Douglas C; Bucklin, Mason H; Chan, Alexandre; Donaldson, Amy R; Hagemann, Tracy M; O'Connell, Mary Beth; Rodgers, Philip T; Tennant, Sarah; Thomas, Zachariah

    2014-05-01

    The American College of Clinical Pharmacy 2013 Educational Affairs Committee was charged with developing recommendations for the minimum qualifications required for clinical pharmacy practice faculty in United States colleges and schools of pharmacy with respect to education, postgraduate training, board certification, and other experiences. From a review of the literature, the committee recommends that clinical pharmacy practice faculty possess the following minimum qualifications, noting that, for some positions, additional qualifications may be necessary. Clinical pharmacy practice faculty should possess the Doctor of Pharmacy degree from an Accreditation Council for Pharmacy Education–accredited institution. In addition, faculty should have completed a postgraduate year one (PGY1) residency or possess at least 3 years of direct patient care experience. Faculty who practice in identified areas of pharmacotherapy specialization, as identified by American Society of Health-System Pharmacists postgraduate year two (PGY2) residency guidelines, should have completed a PGY2 residency in that area of specialty practice. Alternatively, faculty should have completed a minimum of a PGY1 residency and 1 additional year of practice, with at least 50% of time spent in their area of specialization, which is documented in a portfolio, or 4 years of direct patient care in their area of specialization, which is documented in a portfolio. Fellowship training or a graduate degree (e.g., Ph.D.) should be required for research-intensive clinical faculty positions. All faculty should obtain structured teaching experience during or after postgraduate training, preferably through a formal teaching certificate program or through activities documented in a teaching portfolio. A baseline record of scholarship should be obtained before hire as clinical pharmacy practice faculty through exposure in postgraduate programs or previous employment. Faculty should be board certified before hire

  6. Qualification requirements of guided ultrasonic waves for inspection of piping in light water reactors

    SciTech Connect

    Meyer, R. M.; Ramuhalli, P.; Doctor, S. R.; Bond, L. J.

    2013-01-25

    It is anticipated that guided ultrasonic wave (GUW) techniques will eventually see widespread application in the nuclear power industry as there are several near-term and future needs that could benefit from the availability of GUW technologies. Already, GUW techniques are receiving consideration for inspecting buried piping at nuclear power plants and future applications may include several Class 1 and 2 components. To accept the results of a nondestructive examination of safety critical components, the U.S. Nuclear Regulatory Commission requires that the examinations be performed using qualified equipment, personnel, and procedures. As the use of GUW techniques becomes more frequent, qualification may be required. Performance demonstration has been the approach to qualifying conventional NDE methods in the nuclear power industry. This paper highlights potential issues and research needs associated with facilitating GUW qualification for the nuclear power industry. Parametric studies of essential inspection parameters are necessary to understand their influence on inspection performance. The large volume sampling capability introduces several challenges for qualifying GUW techniques including the quantification of performance, potential interference caused by the presence of multiple flaws in the inspection region, and the practicality of manufacturing several large qualification specimens. Computer simulation may have a significant role in reducing the experimental burden associated with qualifying GUW techniques for nuclear power plant examinations.

  7. Qualification requirements of guided ultrasonic waves for inspection of piping in light water reactors

    NASA Astrophysics Data System (ADS)

    Meyer, R. M.; Ramuhalli, P.; Doctor, S. R.; Bond, L. J.

    2013-01-01

    It is anticipated that guided ultrasonic wave (GUW) techniques will eventually see widespread application in the nuclear power industry as there are several near-term and future needs that could benefit from the availability of GUW technologies. Already, GUW techniques are receiving consideration for inspecting buried piping at nuclear power plants and future applications may include several Class 1 and 2 components. To accept the results of a nondestructive examination of safety critical components, the U.S. Nuclear Regulatory Commission requires that the examinations be performed using qualified equipment, personnel, and procedures. As the use of GUW techniques becomes more frequent, qualification may be required. Performance demonstration has been the approach to qualifying conventional NDE methods in the nuclear power industry. This paper highlights potential issues and research needs associated with facilitating GUW qualification for the nuclear power industry. Parametric studies of essential inspection parameters are necessary to understand their influence on inspection performance. The large volume sampling capability introduces several challenges for qualifying GUW techniques including the quantification of performance, potential interference caused by the presence of multiple flaws in the inspection region, and the practicality of manufacturing several large qualification specimens. Computer simulation may have a significant role in reducing the experimental burden associated with qualifying GUW techniques for nuclear power plant examinations.

  8. Novel nanomaterials based on 5,10,15,20-tetrakis(3,4-dimethoxyphenyl)-21H,23H-porphyrin entrapped in silica matrices

    SciTech Connect

    Fagadar-Cosma, Eugenia; Enache, Corina; Vlascici, Dana; Fagadar-Cosma, Gheorghe; Vasile, Mihaela; Bazylak, Grzegorz

    2009-12-15

    The present study is dealing with the obtaining of transparent hybrid silica materials encapsulating 5,10,15,20-tetrakis(3,4-dimethoxyphenyl)-21H,23H-porphyrin designated for advanced optoelectronic devices. The porphyrin was synthesized by three methods: an Adler-type reaction between pyrrole and 3,4-dimethoxybenzaldehyde in propionic acid medium; by Lindsey condensation of pyrrole with 3,4-dimethoxybenzaldehyde in the presence of BF{sub 3}.OEt{sub 2} and by a multicomponent reaction by simultaneously using of pyrrole and two different aldehydes: 3,4-dimethoxybenzaldehyde and 3-hydroxybenzaldehyde. The 3,4-dimethoxyphenyl substituted porphyrin was characterized by HPLC, TLC, UV-vis, FT-IR, {sup 1}H NMR and {sup 13}C NMR analysis. Excitation and emission spectra were also discussed in terms of pH conditions. The hybrid materials, consisting in the porphyrin encapsulated in silica matrices, have been prepared successfully via the two steps acid-base catalyzed hydrolysis and condensation of tetraethylorthosilicate using different approaches of the sol-gel process: in situ, by impregnation and by sonication. The synthetic conditions and the compositions were monitored and characterized by using spectroscopic methods such as FT-IR, fluorescence and UV-vis. Atomic force microscopy (AFM) has been applied to observe the columnar or pyramidal nanostructures which are formed by the immobilization of porphyrin on the silica matrices.

  9. Synthesis, structural elucidation, solvatochromism and spectroscopic properties of some azo dyes derived from 6-chloro-4-hydroxyquinoline-2(1H)-one

    NASA Astrophysics Data System (ADS)

    Rufchahi, E. O. Moradi; Gilani, A. Ghanadzadeh; Taghvaei, V.; Karimi, R.; Ramezanzade, N.

    2016-03-01

    Malondianilide (I) derived from p-chloroaniline was cyclized to 6-chloro-4-hydroxyquinoline-2(1H)-one (II) in moderately good yield using polyphosphoric acid as catalyst. This compound was then coupled with some diazotized aromatic amines to give the corresponding azo disperse dyes 1-12. A systematic study of the effect of solvent, acid, base and pH upon the electronic absorption spectra of the dyes 1-12 was carried out. In DMSO, DMF, CH3CN, CHCl3, EtOH and acidic media (CH3COOH, acidified EtOH) these dyes that theoretically may be involved in azo-hydrazone tautomerism have been detected only as hydrazone tautomers T1 and T2. The acidic dissociation constants of the dyes were measured in 80 vol% ethanol-water solution at room temperature and ionic strength of 0.1. The results were correlated by the Hammett-type equation using the substituent constants σx.

  10. Dichloridobis{2-[(1H-1,2,4-triazol-1-yl)meth­yl]-1H-benzimidazole-κN 3}­zinc(II)

    PubMed Central

    Zhang, Wei-Peng; Zhang, Jiao-Lin; Hao, Bao-Lian; Yang, Huai-Xia

    2013-01-01

    In the title complex, [ZnCl2(C10H9N5)2], the ZnII ion is coordinated by two N atoms from two 2-[(1H-1,2,4-triazol-1-yl)meth­yl]-1H-benzimidazole (tmb) ligands and by two chloride ligands in a slightly distorted tetra­hedral geometry. In the tmb ligands, the benzimidazole rings systems are essentially planar, with maximum deviations from the mean plane of 0.021 (3) and 0.030 (3) Å, and form dihedral angles of 73.2 (2) and 83.5 (2)° with the triazole rings. In the crystal, N—H⋯N hydrogen bonds link complex mol­ecules into chains along [010]. In addition, weak C—H⋯Cl and C—H⋯N hydrogen bonds complete a three-dimensional network. Two weak intra­molecular C—H⋯Cl hydrogen bonds are also observed. PMID:23723759

  11. Novel bipyridinyl oxadiazole-based metal coordination complexes: High efficient and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones through the Biginelli reactions

    NASA Astrophysics Data System (ADS)

    Wang, Jin-Hua; Zhang, E.; Tang, Gui-Mei; Wang, Yong-Tao; Cui, Yue-Zhi; Ng, Seik Weng

    2016-09-01

    Three new metal coordination complexes, namely, [Co(BPO)2(H2O)4](BS)2(H2O)2 (1), [Co(BPO)2(H2O)4](ABS)2(H2O)2 (2), [Co(BPO)2(H2O)4](MBS)2(H2O)2 (3) [BPO=2,5-di(pyridin-4-yl)-1,3,4-oxadiazole, BS=benzenesulphonate, ABS=4-aminobenzenesulphonate, MBS=4-methylbenzenesulphonate] were obtained under hydrothermal conditions. Complexes 1-3 were structurally characterized by single-crystal X-ray diffraction, powder X-ray diffraction, IR and thermogravimetric analyses (TGA). All of them display a zero-dimensional motif, in which strong intermolecular hydrogen bonding interactions (O-H···O/N) and packing interactions (C-H···π and π···π) make them achieve a three-dimensional supramolecular architecture. The primary catalytic results of these three complexes show that high efficiency for the green synthesis of a variety of 3,4-dihydropyrimidin-2(1H)-ones was observed under solvent free conditions through Biginelli reactions. The present catalytic protocols exhibit advantages such as excellent yield, easy isolation, eco-friendly conditions, and short reaction time.

  12. Structural, optical and dispersion properties of 5,10,15,20-tetraphenyl-21H,23H-porphyrin zinc thin films

    NASA Astrophysics Data System (ADS)

    Zeyada, Hamdy M.; Makhlouf, Mohamed M.; Ali, Mohamed A.

    2016-02-01

    The thin films of 5,10,15,20-tetraphenyl-21H,23H-porphyrin zinc, ZnTPP, were successfully prepared by the thermal evaporation technique. The structure formation and optical properties of ZnTPP thin films were studied. The surface morphology and structural characteristics of ZnTPP thin films were analyzed by atomic force microscopy (AFM) and X-ray diffraction (XRD) techniques, respectively. The optical constants of ZnTPP films were measured by spectrophotometer measurements of the transmittance and reflectance at a normal incidence of light in the spectral wavelength range from 200 to 2500 nm. The absorption spectrum of ZnTPP films showed four absorption bands, namely, the Q, B, N, and M bands. Anomalous dispersion was observed in the absorption region and normal dispersion occurred in the transparent region of the spectrum. We adopted the multi-oscillator and the single-oscillator models to interpret the results of anomalous and normal dispersion characteristics, respectively. The energy band gap of ZnTPP films was measured and the type of electron transition was determined to be the indirect allowed transition. The annealing process had an obvious effect on the morphology, structure, optical constants, and spectral dispersion parameters of ZnTPP thin films.

  13. Equipment qualification issues research and resolution: Status report

    SciTech Connect

    Bonzon, L.L.; Wyant, F.J.; Bustard, L.D.; Gillen, K.T.

    1986-11-01

    Since its inception in 1975, the Qualification Testing Evaluation (QTE) Program has produced numerous results pertinent to equipment qualification issues. Many have been incorporated into Regulatory Guides, Rules, and industry practices and standards. This report summarizes the numerous reports and findings to date. Thirty separate issues are discussed encompassing three generic areas: accident simulation methods, aging simulation methods, and special topics related to equipment qualification. Each issue-specific section contains (1) a brief description of the issue, (2) a summary of the applicable research effort, and (3) a summary of the findings to date.

  14. Qualification of active mechanical components for nuclear power plants

    SciTech Connect

    Allen, R.D.; Mollerus, F.J.

    1983-11-01

    The Electric Power Research Institute has undertaken a study of active safety related mechanical components in domestic nuclear plants to determine what qualification information exists and to establish a plan for qualification of those components. Active safety related mechanical components are those which undergo mechanical motion to perform a safety function. The overall objective of the study is to recommend appropriate methods and realistic criteria for the environmental, seismic and dynamic qualification of active mechanical components. This paper presents the results of progress in this project through May 1983.

  15. Staubli TX-90XL robot qualification at the LLIHE.

    SciTech Connect

    Covert, Timothy Todd

    2010-10-01

    The Light Initiated High Explosive (LIHE) Facility uses a robotic arm to spray explosive material onto test items for impulse tests. In 2007, the decision was made to replace the existing PUMA 760 robot with the Staubli TX-90XL. A qualification plan was developed and implemented to verify the safe operating conditions and failure modes of the new system. The robot satisfied the safety requirements established in the qualification plan. A performance issue described in this report remains unresolved at the time of this publication. The final readiness review concluded the qualification of this robot at the LIHE facility.

  16. ITER CENTRAL SOLENOID COIL INSULATION QUALIFICATION

    SciTech Connect

    Martovetsky, N N; Mann, T L; Miller, J R; Freudenberg, K D; Reed, R P; Walsh, R P; McColskey, J D; Evans, D

    2009-06-11

    An insulation system for ITER Central Solenoid must have sufficiently high electrical and structural strength. Design efforts to bring stresses in the turn and layer insulation within allowables failed. It turned out to be impossible to eliminate high local tensile stresses in the winding pack. When high local stresses can not be designed out, the qualification procedure requires verification of the acceptable structural and electrical strength by testing. We built two 4 x 4 arrays of the conductor jacket with two options of the CS insulation and subjected the arrays to 1.2 million compressive cycles at 60 MPa and at 76 K. Such conditions simulated stresses in the CS insulation. We performed voltage withstand tests and after end of cycling we measured the breakdown voltages between in the arrays. After that we dissectioned the arrays and studied micro cracks in the insulation. We report details of the specimens preparation, test procedures and test results.

  17. Flight qualification test results for violet cells

    NASA Technical Reports Server (NTRS)

    Gaddy, E. M.

    1974-01-01

    The violet solar cell has been submitted to a flight qualification program. The tasks included in this program were: to define the violet cell's electrical output from -100 C to +100 C; to determine the violet cell's degradation under 2 MeV, 1 MeV and .3 MeV proton irradiation, under a high humidity environment and under ultraviolet light; to thermal cycle two similar modules of violet cells; to flight qualify a full size violet cell panel for the IMP-J flight; and to obtain a primary balloon-flown standard of the violet cell type. The results of these tests demonstrate that the violet cell is fully qualified for space flight use with no further development work. The tests show that the violet cell offers a power increase of at least twenty-one per cent over presently available commercial cells.

  18. ITER Central Solenoid Coil Insulation Qualification

    SciTech Connect

    Martovetsky, Nicolai N; Mann Jr, Thomas Latta; Miller, John L; Freudenberg, Kevin D; Reed, Richard P; Walsh, Robert P; McColskey, J D; Evans, D

    2010-01-01

    An insulation system for ITER Central Solenoid must have sufficiently high electrical and structural strength. Design efforts to bring stresses in the turn and layer insulation within allowables failed. It turned out to be impossible to eliminate high local tensile stresses in the winding pack. When high local stresses can not be designed out, the qualification procedure requires verification of the acceptable structural and electrical strength by testing. We built two 4x4 arrays of the conductor jacket with two options of the CS insulation and subjected the arrays to 1.2 million compressive cycles at 60 MPa and at 76 K. Such conditions simulated stresses in the CS insulation. We performed voltage withstand tests and after end of cycling we measured the breakdown voltages between in the arrays. After that we dissectioned the arrays and studied micro cracks in the insulation. We report details of the specimens preparation, test procedures and test results.

  19. NASA DFRC Practices for Prototype Qualification

    NASA Technical Reports Server (NTRS)

    Lokos, William A.

    2009-01-01

    This slide presentation reviews the practices that Dryden uses for qualification of the prototypes of aircraft. There are many views of aircraft that Dryden has worked with. Included is a discussion of basic considerations for strength, a listing of standards and references, a discussion of typical safety of flight approaches, a discussion of the prototype design, using the X-29A as an example, and requirements for new shapes (i.e., the DAST-ARW1 , F-8 Super Critical Wing, AFTI/F-111 MAW), new control laws (i.e., AAW F-18), new operating envelope (i.e., F-18 HARV), limited sope add-on or substitute structure (i.e., SR-71 LASRE, ECLIPSE, F-16XL SLFC), and extensively modified or replaced structure (i.e., SOFIA, B747SP). There is a listing of causes for the failure of the prototype.

  20. Future trends in spacecraft design and qualification

    NASA Technical Reports Server (NTRS)

    Venneri, Samuel L.; Hanks, Brantley R.; Pinson, Larry D.

    1986-01-01

    Material and structures issues that must be resolved in order to develop the technology data base needed to design and qualify the next generation of large flexible spacecraft are discussed. This invoves the development of new ground test and analysis methods and the conduct of appropriate instrumented in-space flight experiments for final verification. A review of present understanding of material behavior in the space environment and identification of future needs is presented. The dynamic verification and subsequent qualification of a spacecraft structure currently rely heavily on ground-based tests, coupled with the verified analysis model. Future space structures, such as large antennas, Space Station and other large platforms, will be of sizes difficult to test using current ground test methods. In addition to size, other complex factors, such as low natural frequencies, lightweight construction and many structural joints, will also contribute significant problems to the test and qualification process in an Earth-gravity environment. These large spacecraft will also require new technology for controlling the configuration and dynamic deformations of the structures. Future trend in large flexible structures will also involve long-life design missions (10 to 20 years). In low earth orbit (LEO), materials will be subjected to repeated thermal cycles, ultraviolet radiation, atomic oxygen and vacuum. For high orbits such as geo-synchronous earth orbit (GEO), the materials will also be subjected to large doses of high energy electrons and protons. Understanding degradation and material stability over long-mission time periods will confront the designer with many issues that are unresolved today.