Science.gov

Sample records for 238u-230th-226ra discussions sur

  1. Mid-ocean ridge basalt generation along the slow-spreading, South Mid-Atlantic Ridge (5-11°S): Inferences from 238U-230Th-226Ra disequilibria

    NASA Astrophysics Data System (ADS)

    Turner, Simon; Kokfelt, Thomas; Hauff, Folkmar; Haase, Karsten; Lundstrom, Craig; Hoernle, Kaj; Yeo, Isobel; Devey, Colin

    2015-11-01

    U-series disequilibria have provided important constraints on the physical processes of partial melting that produce basaltic magma beneath mid-ocean ridges. Here we present the first 238U-230Th-226Ra isotope data for a suite of 83 basalts sampled between 5°S and 11°S along the South Mid-Atlantic Ridge. This section of the ridge can be divided into 5 segments (A0-A4) and the depths to the ridge axis span much of the global range, varying from 1429 to 4514 m. Previous work has also demonstrated that strong trace element and radiogenic isotope heterogeneity existed in the source regions of these basalts. Accordingly, this area provides an ideal location in which to investigate the effects of both inferred melt column length and recycled materials. 226Ra-230Th disequilibria indicate that the majority of the basalts are less than a few millennia old such that their 230Th values do not require any age correction. The U-Th isotope data span a significant range from secular equilibrium up to 32% 230Th excess, also similar to the global range, and vary from segment to segment. However, the (230Th/238U) ratios are not negatively correlated with axial depth and the samples with the largest 230Th excesses come from the deepest ridge segment (A1). Two sub-parallel and positively sloped arrays (for segments A0-2 and A3 and A4) between (230Th/238U) and Th/U ratios can be modelled in various ways as mixing between melts from peridotite and recycled mafic lithologies. Despite abundant evidence for source heterogeneity, there is no simple correlation between (230Th/238U) and radiogenic isotope ratios suggesting that at least some of the trace element and radiogenic isotope variability may have been imparted to the source regions >350 kyr prior to partial melting to produce the basalts. In our preferred model, the two (230Th/238U) versus Th/U arrays can be explained by mixing of melts from one or more recycled mafic lithologies with melts derived from chemically heterogeneous

  2. 238U-230Th-226Ra disequilibria in dacite and plagioclase from the 2004-2005 eruption of Mount St. Helens: Chapter 36 in A volcano rekindled: the renewed eruption of Mount St. Helens, 2004-2006

    USGS Publications Warehouse

    Cooper, Kari M.; Donnelly, Carrie T.; Sherrod, David R.; Scott, William E.; Stauffer, Peter H.

    2008-01-01

    230Th)/(232Th) measured for the 1980s reference suite. However, (230Th)/(232Th) for plagioclase separates for dome samples erupted during October and November 2004 are significantly different from corresponding whole-rock values, which suggests that a large fraction (>30 percent) of crystals in each sample are foreign to the host liquid. Furthermore, plagioclase in the two 2004 samples have U-series characteristics distinct from each other and from plagioclase in dacite erupted in 1982, indicating that (1) the current eruption must include a component of crystals (and potentially associated magma) that were not sampled by the 1980-86 eruption, and (2) dacite magmas erupted only a month apart in 2004 contain different populations of crystals, indicating that this foreign component is highly heterogeneous within the 2004-5 magma reservoir.

  3. Crystal Histories and Crustal Magmas: Insights into Magma Storage from U-Series Crystal Ages

    NASA Astrophysics Data System (ADS)

    Cooper, K. M.

    2014-12-01

    The dynamic processes operating within crustal magma reservoirs control many aspects of the chemical composition of erupted magmas, and crystals in volcanic rocks can provide a temporally-constrained archive of these changing environments. A new compilation of 238U-230Th ages of accessory phases and 238U-230Th-226Ra ages of bulk mineral separates of major phases documents that crystals in individual samples often have ages spanning most of the history of a volcanic center. Somewhat surprisingly, this observation holds for surface analyses as well as interior analyses, indicating that the latest stages of growth took place at different times for different grains. Nevertheless, average ages of surfaces are younger than interiors (as expected), and the dominant surface age population is often within error of eruption age. In contrast to accessory phase ages, less than half of the bulk separate 238U-230Th-226Ra ages for major phases are more than 10 kyr older than eruption. This suggests that major phases may in general reflect a later stage of development of an eruptible magma body than do accessory phases, or that the extent of discordance between ages of major and accessory phases reflects the extent to which a crystal mush was remobilized during processes leading to eruption. Crystal ages are most useful for illuminating magmatic processes when combined with crystal-scale trace-element or isotopic data, and I will present several case studies where such combined data sets exist. For example, at Yellowstone and at Okataina Caldera Complex, New Zealand, the combination zircon surface and interior analyses (of age, Hf isotopic, and trace-element data) with bulk dating and in-situ trace-element and isotopic compositions of feldspar allows a comparison of the early history of storage in a crystal mush with the later history of melt extraction and further crystallization prior to eruption, thus tracking development of erupted magma bodies from storage through eruption.

  4. Recent volcanic accretion at 9°N-10°N East Pacific Rise as resolved by combined geochemical and geological observations

    NASA Astrophysics Data System (ADS)

    Waters, C. L.; Sims, K. W. W.; Soule, S. A.; Blichert-Toft, J.; Dunbar, N. W.; Plank, T.; Prytulak, J.; Sohn, R. A.; Tivey, M. A.

    2013-08-01

    The ridge crest at 9°N-10°N East Pacific Rise (EPR) is dominated by overlapping lava flows that have overflowed the axial summit trough and flowed off-axis, forming a shingle-patterned terrain up to ˜2-4 km on either side of the axial summit trough. In this study, we employ 230Th-226Ra dating methods, in conjunction with geochemistry and seafloor geological observations, in an effort to discern the stratigraphic relationships between adjacent flows. We measured major and trace elements and 87Sr/86Sr, 143Nd/144Nd, 176Hf/177Hf, and 238U-230Th-226Ra for lava glass samples collected from several flow units up to ˜2 km away from the axial summit trough on the ridge crest at 9°50'N EPR. Statistical analysis of the 238U-230Th-226Ra data indicates that all but one measured sample from these flows cannot be resolved from the zero-age population; thus, we cannot confidently assign model ages to samples for discerning stratigraphic relationships among flows. However, because groups of samples can be distinguished based on similarities in geochemical compositions, particularly incompatible element abundances with high precision-normalized variability such as U and Th, and because the range of compositions is much greater than that represented by samples from the 1991-1992 and 2005-2006 eruptions, we suggest that the dive samples represent 6-10 eruptive units despite indistinguishable model ages. Geochemical variability between individual flows with similar ages requires relatively rapid changes in parental melt composition over the past ˜2 ka, and this likely reflects variations in the relative mixing proportions of depleted and enriched melts derived from a heterogeneous mantle source.

  5. Timescales of magma differentiation from basalt to andesite beneath Hekla Volcano, Iceland: Constraints from U-series disequilibria in lavas from the last quarter-millennium flows

    NASA Astrophysics Data System (ADS)

    Chekol, Takele A.; Kobayashi, Katsura; Yokoyama, Tetsuya; Sakaguchi, Chie; Nakamura, Eizo

    2011-01-01

    Measurements of 238U- 230Th- 226Ra disequilibria, Sr-Nd-Pb-Hf isotopes and major-trace elements have been conducted for lavas erupted in the last quarter-millennium at Hekla volcano, Iceland. The volcanic rocks range from basalt to dacite. Most of the lavas (excluding dacitic samples) display limited compositional variations in radiogenic Sr-Nd-Pb-Hf isotopes ( 87Sr/ 86Sr = 0.70319-0.70322; 143Nd/ 144Nd = 0.51302-0.51305; 206Pb/ 204Pb = 19.04-19.06; 207Pb/ 204Pb = 15.53-15.54; 208Pb/ 204Pb = 38.61-38.65; 176Hf/ 177Hf = 0.28311-0.28312). All the samples possess ( 230Th/ 238U) disequilibrium with 230Th excesses, and they show systematic variations in ( 230Th/ 232Th) and ( 238U/ 232Th) ratios. The highest 226Ra excesses occur in the basalt and most differentiated andesite lavas, while some basaltic-andesite lavas have ( 226Ra/ 230Th) ratio that are close to equilibrium. The 238U- 230Th- 226Ra disequilibria variations cannot be produced by simple closed-system fractional crystallization with radioactive decay of 230Th and 226Ra in a magma chamber. A closed-system fractional crystallization model and assimilation and fractional crystallization (AFC) model indicate that the least differentiated basaltic andesites were derived from basalt by fractional crystallization with a differentiation age of ˜24 ± 11 kyr, whereas the andesites were formed by assimilation of crustal material and fractionation of the basaltic-andesites within 2 kyr. Apatite is inferred to play a key role in fractionating the parent-daughter nuclides in 230Th- 238U and 226Ra- 230Th to make the observed variations. Our proposed model is that several batches of basaltic-andesite magmas that formed by fractional crystallization of a basaltic melt from a deeper reservoir, were periodically injected into the shallow crust to form individual magma pockets, and subsequently modifying the original magma compositions via simultaneous assimilation and fractional crystallization. The assimilant is the dacitic

  6. [Radiation risk assessment for plant reference species (Pinus sylvestris and Vicia cracca) from the area of radium production waste storage].

    PubMed

    Evseeva, T I; Geras'kin, S A; Belykh, E S; Maĭstrenko, T A; Vakhrusheva, O M

    2012-01-01

    The risk of an enhanced level of radionuclides of the uranium and thorium decay series in the environment for reference plant species (Pinus sylvestris and Vicia cracca) was assessed. 238U, 230Th, 226Ra, 210Po, 232Th and 228Th concentration factors for plants were found to be lower than one. The aboveground parts of Vicia cracca sampled from the area of the radium production waste storage mainly accumulated 22Ra, Pinus sylvestris branches--210Pb, 226Ra and 210Po. LOEDR calculated for the chromosome aberration frequency in both plant studies was 17-71 microGy/h. LOERD values for the reproductive capacity decrease in P. sylvestris and V. cracca were 17-71 microGy/h and 116-258 microGy/h, correspondingly. EDR10 for the chromosome aberration frequency in P. sylvestris and V. cracca were 148 and 347 microGy/h, that is, correspondingly, 255 and 708 times higher that background values. EDR10 for the plant reproductive capacity was 11-34 microGy/h, which 19-69 times increases the background values.

  7. Evolution of vegetation and soil nutrients after uranium mining in Los Ratones mine (Cáceres, Spain).

    PubMed

    Pérez-Fernández, María A; Vera-Tomé, Feliciano; Blanco-Rodríguez, María P; Lozano, Juan C

    2014-06-01

    The evolution of vegetation structure following mine rehabilitation is rather scarce in the literature. The concentration of long-lived radionuclides of the (238)U series might have harmful effects on living organisms. We studied soil properties and the natural vegetation occurring along a gradient in Los Ratones, an area rehabilitated after uranium mining located in Cáceres, Spain. Soil and vegetation were sampled seasonally and physical and chemical properties of soil were analysed, including natural isotopes of (238)U, (230)Th, (226)Ra and (210)Pb. Species richness, diversity, evenness and plant cover were estimated and correlated in relation to soil physical and chemical variables. The location of the sampling sites along a gradient had a strong explanatory effect on the herbaceous species, as well as the presence of shrubs and trees. Seasonal effects of the four natural isotopes were observed in species richness, species diversity and plant cover; these effects were directly related to the pH values in the soil, this being the soil property that most influences the plant distribution. Vegetation in the studied area resembles that of the surroundings, thus proving that the rehabilitation carried out in Los Ratones mine was successful in terms of understorey cover recovery.

  8. [Radiation risk assessment for plant reference species (Pinus sylvestris and Vicia cracca) from the area of radium production waste storage].

    PubMed

    Evseeva, T I; Geras'kin, S A; Belykh, E S; Maĭstrenko, T A; Vakhrusheva, O M

    2012-01-01

    The risk of an enhanced level of radionuclides of the uranium and thorium decay series in the environment for reference plant species (Pinus sylvestris and Vicia cracca) was assessed. 238U, 230Th, 226Ra, 210Po, 232Th and 228Th concentration factors for plants were found to be lower than one. The aboveground parts of Vicia cracca sampled from the area of the radium production waste storage mainly accumulated 22Ra, Pinus sylvestris branches--210Pb, 226Ra and 210Po. LOEDR calculated for the chromosome aberration frequency in both plant studies was 17-71 microGy/h. LOERD values for the reproductive capacity decrease in P. sylvestris and V. cracca were 17-71 microGy/h and 116-258 microGy/h, correspondingly. EDR10 for the chromosome aberration frequency in P. sylvestris and V. cracca were 148 and 347 microGy/h, that is, correspondingly, 255 and 708 times higher that background values. EDR10 for the plant reproductive capacity was 11-34 microGy/h, which 19-69 times increases the background values. PMID:22690582

  9. Evolution of vegetation and soil nutrients after uranium mining in Los Ratones mine (Cáceres, Spain).

    PubMed

    Pérez-Fernández, María A; Vera-Tomé, Feliciano; Blanco-Rodríguez, María P; Lozano, Juan C

    2014-06-01

    The evolution of vegetation structure following mine rehabilitation is rather scarce in the literature. The concentration of long-lived radionuclides of the (238)U series might have harmful effects on living organisms. We studied soil properties and the natural vegetation occurring along a gradient in Los Ratones, an area rehabilitated after uranium mining located in Cáceres, Spain. Soil and vegetation were sampled seasonally and physical and chemical properties of soil were analysed, including natural isotopes of (238)U, (230)Th, (226)Ra and (210)Pb. Species richness, diversity, evenness and plant cover were estimated and correlated in relation to soil physical and chemical variables. The location of the sampling sites along a gradient had a strong explanatory effect on the herbaceous species, as well as the presence of shrubs and trees. Seasonal effects of the four natural isotopes were observed in species richness, species diversity and plant cover; these effects were directly related to the pH values in the soil, this being the soil property that most influences the plant distribution. Vegetation in the studied area resembles that of the surroundings, thus proving that the rehabilitation carried out in Los Ratones mine was successful in terms of understorey cover recovery. PMID:24450758

  10. Insights into the Galápagos plume from uranium-series isotopes of recently erupted basalts

    NASA Astrophysics Data System (ADS)

    Handley, Heather K.; Turner, Simon; Berlo, Kim; Beier, Christoph; Saal, Alberto E.

    2011-09-01

    Uranium-series isotopes (238U-230Th-226Ra-210Pb), major element, trace element, and Sr-Nd isotopic data are presented for recent (<60 years old) Galápagos archipelago basalts. Volcanic rocks from all centers studied (Fernandina, Cerro Azul, Sierra Negra, and Wolf Volcano) display 230Th excesses (4%-15%) and steep rare earth element (REE) patterns indicative of residual garnet during partial melting of their mantle source. Rare earth element modeling suggests that only a few percent of garnet is involved. Correlations between (238U/232Th), radiogenic isotopes and Nb/Zr ratio suggest that the U/Th ratio of these Galápagos volcanic rocks is primarily controlled by geochemical source variations and not fractionation during partial melting. The lowest (230Th/238U) ratio is not observed at Fernandina (the supposed center of the plume) but at the more geochemically "depleted" Wolf Volcano, further to the north. Small radium excesses are observed for all samples with (226Ra/230Th) ranging from 1.107 to 1.614. The 226Ra-230Th disequilibria do not correlate with other uranium-series parent-daughter nuclide pairs or geochemical data, suggesting modification at shallow levels on timescales relevant to the half-life of 226Ra (1600 years). The combination of 226Ra and 210Pb excesses is inconsistent with interaction of magma with cumulate material unless decoupling of 210Pb (or an intermediate daughter, such as 222Rn) occurs prior to modification of Ra-Th disequilibria. An intriguing correlation of (210Pb/226Ra)0 with Nb/Zr and radiogenic isotopes requires further investigation but suggests possible control via magmatic degassing and accumulation that may somehow be related to source heterogeneities.

  11. Transitional melt flow in downwelling arc mantle

    NASA Astrophysics Data System (ADS)

    Petford, N.; Turner, S.

    2005-12-01

    226Ra excesses in arc lavas are inferred to result from fluid addition from the subducting plate and their preservatrion provides an important constraint on the magma extraction rate, indicating rapid transport from source to surface <1000 years. This requires channelled melt ascent but an important question is whether melt can be supplied to veins sufficiently rapidly to preserve short-lived isotope disequilibria. Such high rates require a fluid dynamical explanation, yet are incompatible with a transport history governed by compaction and simple porous flow. We present the results of a 2D axisymmetric numerical model that simulates the lateral flow of viscous melt into low pressure channels in downwelling subarc mantle. Finite element coupling provides a simultaneous solution to the fluid dynamical equations linking the transition between porous and channel flow. The transitioning (Brinkman) local flow field is non-linear and position-dependent, increasing in velocity towards the outer channel boundary. Average maximum lateral flow rates for a reference matrix permeability of 10- 15m2 are c. 10-4m/s, a factor of 104 to 100 times faster than matrix downweling velocites based on plate tectonic rates. Upwards melt flow rates in the channel (r = 0.1 m) are c. 0.03 m/s. Vertical (downwards) melt flow in the porous matrix is c. 104 lower than lateral migration veocities. These physical results are consistent with a downgoing arc mantle wedge source region where melting and extraction are sufficiently rapid to preserve source-derived 238U-230 Th-226Ra and potentially also 226Ra-210Pb disequilibria.

  12. Geochemical hosts of solubilized radionuclides in uranium mill tailings

    USGS Publications Warehouse

    Landa, E.R.; Bush, C.A.

    1990-01-01

    The solubilization and subsequent resorption of radionuclides by ore components or by reaction products during the milling of uranium ores may have both economic and environmental consequences. Particle-size redistribution of radium during milling has been demonstrated by previous investigators; however, the identification of sorbing components in the tailings has received little experimental attention. In this study, uranium-bearing sandstone ore was milled, on a laboratory scale, with sulfuric acid. At regular intervals, filtrate from this suspension was placed in contact with mixtures of quartz sand and various potential sorbents which occur as gangue in uranium ores; the potential sorbents included clay minerals, iron and aluminum oxides, feldspar, fluorspar, barite, jarosite, coal, and volcanic glass. After equilibration, the quartz sand-sorbent mixtures were separated from the filtrate and radioassayed by gamma-spectrometry to determine the quantities of 238U, 230Th, 226Ra, and 210Pb sorbed, and the radon emanation coefficients. Sorption of 238U was low in all cases, with maximal sorptions of 1-2% by the bentonite- and coal-bearing samples. 230Th sorption also was generally less than 1%; maximal sorption here was observed in the fluorspar-bearing sample and appears to be associated with the formation of gypsum during milling. 226Ra and 210 Pb generally showed higher sorption than the other nuclides - more than 60% of the 26Ra solubilized from the ore was sorbed on the barite-bearing sample. The mechanism (s) for this sorption by a wide variety of substrates is not yet understood. Radon emanation coefficients of the samples ranged from about 5 to 30%, with the coal-bearing samples clearly demonstrating an emanating power higher than any of the other materials. ?? 1990.

  13. Timescales of storage and recycling of crystal mush at Krafla Volcano, Iceland

    NASA Astrophysics Data System (ADS)

    Cooper, Kari M.; Sims, Kenneth W. W.; Eiler, John M.; Banerjee, Neil

    2016-06-01

    Processes in upper-crustal magma reservoirs such as recharge, magma mixing, recycling of previously crystallized material, and eruption affect both the physical state and the chemical composition of magmas. A growing body of evidence shows that crystals in intermediate or silicic volcanic rocks preserve records of these processes that may be obscured due to mixing in the liquid fraction of magmas. Fewer studies have focused on crystals in basaltic lavas, but these show evidence for a more subtle, but still rich record of magmatic processes. We present new 238U-230Th-226Ra data for plagioclase, combined with δ18O and trace-element measurements of the same crystal populations, from basalts erupted at Krafla Volcanic Center, Iceland. These data document the presence of multiple crystal populations within each sample, with chemical and oxygen isotope heterogeneity at a variety of scales: within individual crystals, between crystals in a given population, between crystal populations within the same sample, and between crystals in lavas erupted from different vents during the same eruption. Comparison to whole-rock or groundmass data shows that the majority of macroscopic crystals are not in trace-element or oxygen isotope equilibrium with their host liquids. The most likely explanation for these data is that the macroscopic crystals originated within a highly heterogeneous crystal mush in the shallow magma reservoir system. U-series and diffusion data indicate that the crystals (and therefore the mush) formed recently (likely within a few thousand years of eruption, and with a maximum age of 8-9 ka), and that the crystals resided in their host magma prior to eruption for decades to a few centuries at most. These data, in conjunction with other recent studies, suggest a model where erupted Icelandic magmas are the result of diverse magmas entering the crust, followed by complex interactions between melts and previously crystallized material at all crustal levels.

  14. Geochemical evolution of historical lavas from Askja Volcano, Iceland: Implications for mechanisms and timescales of magmatic differentiation

    NASA Astrophysics Data System (ADS)

    Kuritani, Takeshi; Yokoyama, Tetsuya; Kitagawa, Hiroshi; Kobayashi, Katsura; Nakamura, Eizo

    2011-01-01

    The mechanisms and the timescales of magmatic evolution were investigated for historical lavas from the Askja central volcano in the Dyngjufjöll volcanic massif, Iceland, using major and trace element and Sr, Nd, and Pb isotopic data, as well as 238U- 230Th- 226Ra systematics. Lavas from the volcano show marked compositional variation from magnesian basalt through ferrobasalt to rhyolite. In the magnesian basalt-ferrobasalt suite (5-10 wt% MgO), consisting of lavas older than 1875 A.D., 87Sr/ 86Sr increases systematically with increasing SiO 2 content; this suite is suggested to have evolved in a magma chamber located at ˜600 MPa through assimilation and fractional crystallization. On the other hand, in the ferrobasalt-rhyolite suite (1-5 wt% MgO), including 1875 A.D. basalt and rhyolite and 20th century lavas, 87Sr/ 86Sr tends to decrease slightly with increasing SiO 2 content. It is suggested that a relatively large magma chamber occupied by ferrobasalt magma was present at ˜100 MPa beneath the Öskjuvatn caldera, and that icelandite and rhyolite magmas were produced by extraction of the less and more evolved interstitial melt, respectively, from the mushy boundary layer along the margin of the ferrobasalt magma chamber, followed by accumulation of the melt to form separate magma bodies. Ferrobasalt and icelandite lavas in the ferrobasalt-rhyolite suite have a significant radioactive disequilibrium in terms of ( 226Ra/ 230Th), and its systematic decrease with magmatic evolution is considered to reflect aging, along with assimilation and fractional crystallization processes. Using a mass-balance model in which simultaneous fractional crystallization, crustal assimilation, and radioactive decay are taken into account, the timescale for the generation of icelandite magma from ferrobasalt was constrained to be <˜3 kyr which is largely dependent on Ra crystal-melt partition coefficients we used.

  15. U-series isotope systematics of mafic magmas from central Oregon: Implications for fluid involvement and melting processes in the Cascade arc

    NASA Astrophysics Data System (ADS)

    Mitchell, Euan C.; Asmerom, Yemane

    2011-12-01

    The Cascade arc is the warm-slab subduction zone global end member, where a broad variety of primitive magmas with highly variable slab fluid signatures have erupted in close spatial and temporal proximity. A number of petrogenetic models have been proposed to explain the occurrence of such diverse magmas, but the source(s) of these magmas and the timing of fluid addition to the sub-arc mantle remain controversial. We present uranium-series isotope data ( 238U- 230Th- 226Ra) for eighteen mafic lavas from the Three Sisters region of the central Oregon Cascades, and for a further six lavas from the rear-arc Newberry Volcano. The majority of these samples have geochemical characteristics (e.g. Nb/Zr, Ba/Zr, 87Sr/ 86Sr) consistent with previously described calc-alkaline basalts from this region of the arc, and indicative of limited fluid involvement at some stage in their genesis. Trace element and long-lived radiogenic isotope modeling suggests that this fluid was derived from dehydration of subducting sediments, and was added to an enriched, garnet-bearing mantle wedge source. The trace element systematics of the lavas are consistent with small degree (< 10%) melts of this fluid-modified source. All samples display ( 230Th/ 238U) and ( 226Ra/ 230Th) ≥ 1, similar to values measured in fresh MORB and other parts of the arc. Results of a dynamic melting model support the interpretation that these lavas are small degree melts of an asthenospheric source, and do not allow for a lithospheric mantle source. However, the U-series data do not permit us to determine whether fluid addition was the trigger for melting, or whether the lavas were generated from a secular equilibrium source that had experienced fluid addition > 350 ka prior to melting. Regardless, modern fluid input is limited and melting is dominantly occurring in response to upwelling and decompression.

  16. The uranium and thorium decay series nuclides in Mt. St. Helens effusives

    NASA Astrophysics Data System (ADS)

    Bennett, J. T.; Krishnaswami, S.; Turekian, K. K.; Melson, W. G.; Hopson, C. A.

    1982-08-01

    The concentrations of the radionuclides 238U, 230Th, 226Ra, 210Pb, 210Po, 232Th, 228Ra and 228Th and the abundances of major elements were determined in samples from all major eruptions of Mt. St. Helens from May 18, 1980 through June 21, 1981. During this time the effusives changed from plagioclase-phyric dacite to a more andesitic composition but the concentrations of U and Th series nuclides were measurably invariant. The average 232Th/ 238U weight ratio in the rocks is 2.4 and the 230Th/ 232Th activity ratio equals the 238U/ 232Th activity ratio indicating no fractionation of U from Th during magma genesis. 226Ra activity is in excess (˜40% on average) of its parent 230Th whereas 228Ra is in radioactive equilibrium with its parent 232Th, constraining the time of magma formation between 30 and 10 4 years prior to eruption. The 210Pb/ 226Ra activity ratios in the samples average 1.0, with a 20% scatter on either side, but allowing for volatile 210Pb loss at time of eruption excess 210Pb over 226Ra is inferred, indicating that the time of magma formation was within the last 150 years. 210Po was virtually absent in the samples immediately after eruption, indicating its total loss by volatilization during eruption. The quantity of 210Po volatilized during the May 18, 1980 event is estimated to be in the range of 300 Ci from the effusives and as much as 5000 Ci total including losses from heated slide material. The 222Rn activity volatilized should have been comparable to the 210Po activity released.

  17. Les torsions sur testicules cryptorchides

    PubMed Central

    Gharbi, Mohamed; Amri, Najmeddine; Chambeh, Wahib; Braiek, Salem; Kamel, Rafik El

    2010-01-01

    Résumé But : La cryptorchidie est une pathologie assez fréquente en urologie. Elle est associée à un risque élevé d’infertilité et de dégénérescence. Elle semble aussi être associée à un risque important de torsion. Cette entité est très peu abordée dans la littérature. Nous rapportons tous les cas de torsion sur testicule cryptorchide observés à notre service dans le but de mieux caractériser cette pathologie et de réduire ainsi le taux d’orchidectomies. Méthodologie : Il s’agit d’une étude rétrospective portant sur tous les cas de torsion sur testicule cryptorchide opérés dans notre service d’urologie entre 1999 et 2007. Les patients ont fait l’objet d’une description basée sur le résumé de leurs observations. Résultats : Les patients étaient âgés de 7 mois à 39 ans. La torsion touchait le testicule droit dans 53 % des cas. Le tableau clinique comportait une douleur au niveau de la région inguinale d’apparition soudaine avec une masse sous-cutanée inflammatoire et douloureuse à ce niveau et surtout un hémiscrotum homolatéral vide. Dans 60 % des cas, le diagnostic était tardif et une orchidectomie a été réalisée. Dans les autre cas, un abaissement du testicule a été réalisé avec orchidopexie controlatéral dans le même temps opératoire. Conclusion : Bien qu’il s’agisse d’une pathologie peu courante, la torsion sur testicule cryptorchide doit être étudiée davantage. Le diagnostic précoce permettra de sauver et d’abaisser le testicule et faciliter ainsi le dépistage d’une éventuelle dégénérescence. PMID:21191497

  18. Discussion Skills.

    ERIC Educational Resources Information Center

    Lowe, William T.

    1984-01-01

    Discussion done right is a marvelous tool for teaching and learning. Suggestions to help teachers improve classroom discussions are presented. Many of the suggestions are based on William S. Howell's and Donald K. Smith's book "Discussion." (RM)

  19. Scored Discussions.

    ERIC Educational Resources Information Center

    Zola, John

    1992-01-01

    Suggests a classroom strategy to help students learn to analyze and discuss significant issues from history and current policy debates. Describes scored discussions in which small groups of students receive points for participation. Provides an example of a discussion on gold mining. Includes an agenda. Explores uses of scored discussions and…

  20. Reframing Discussions

    ERIC Educational Resources Information Center

    Sherry, Michael B.

    2010-01-01

    Recitations and discussions are two types of interactions which have long been of interest to researchers who study classroom discourse in secondary English and Social Studies. According to research, teachers control the discourse during recitations through "inauthentic" questions requiring pre-specified answers. In contrast, discussions involve…

  1. Developing Discussion

    ERIC Educational Resources Information Center

    Maloch, Beth; Bomer, Randy

    2012-01-01

    Researchers and educators have long argued for the importance of providing time and space for rich conversations around literature. This column draws on research to consider how teachers make room for these discussions inside their classrooms. Particularly, the authors consider different dimensions along which teachers might examine and grow…

  2. Instructional Discussion.

    ERIC Educational Resources Information Center

    Nyquist, Jody

    Instructional discussion is a classroom teaching method by which students move through material to a predetermined, new understanding by building on each other's contributions and by utilizing the more experienced learner's (the teacher's) past experiences with the material. This article describes both the characteristics and the planning of…

  3. Risky Discussions

    ERIC Educational Resources Information Center

    Cook, Julian; Jacobs, Neil

    2006-01-01

    This article considers a hypothetical decision by a hypothetical learner about whether or not to participate in an online "discussion", viewed through the lens of risk analysis. It begins with the premise that participation online is desirable but that it involves the participant in risk, a fact that needs to be acknowledged and taken into account…

  4. Pockmarks off Big Sur, California

    USGS Publications Warehouse

    Paull, C.; Ussler, W.; Maher, N.; Greene, H. Gary; Rehder, G.; Lorenson, T.; Lee, H.

    2002-01-01

    A pockmark field was discovered during EM-300 multi-beam bathymetric surveys on the lower continental slope off the Big Sur coast of California. The field contains ??? 1500 pockmarks which are between 130 and 260 m in diameter, and typically are 8-12 m deep located within a 560 km2 area. To investigate the origin of these features, piston cores were collected from both the interior and the flanks of the pockmarks, and remotely operated vehicle observation (ROV) video and sampling transects were conducted which passed through 19 of the pockmarks. The water column within and above the pockmarks was sampled for methane concentration. Piston cores and ROV collected push cores show that the pockmark field is composed of monotonous fine silts and clays and the cores within the pockmarks are indistinguishable from those outside the pockmarks. No evidence for either sediment winnowing or diagenetic alteration suggestive of fluid venting was obtained. 14C measurements of the organic carbon in the sediments indicate continuous sedimentation throughout the time resolution of the radiocarbon technique ( ??? 45000 yr BP), with a sedimentation rate of ??? 10 cm per 1000 yr both within and between the pockmarks. Concentrations of methane, dissolved inorganic carbon, sulfate, chloride, and ammonium in pore water extracted from within the cores are generally similar in composition to seawater and show little change with depth, suggesting low biogeochemical activity. These pore water chemical gradients indicate that neither significant accumulations of gas are likely to exist in the shallow subsurface ( ??? 100 m) nor is active fluid advection occurring within the sampled sediments. Taken together the data indicate that these pockmarks are more than 45000 yr old, are presently inactive, and contain no indications of earlier fluid or gas venting events. ?? 2002 Elsevier Science B.V. All rights reserved.

  5. AirMSPI PODEX BigSur Terrain Images

    Atmospheric Science Data Center

    2013-12-13

    ... from the PODEX 2013 Campaign   Big Sur target (Big Sur, California) 02/03/2013 Terrain-projected   Select ...   Version number   For more information, see the Data Product Specifications (DPS)   ...

  6. Using short-lived nuclides of the U- and Th-series to probe the kinetics of colloid migration in forested soils

    NASA Astrophysics Data System (ADS)

    Rihs, Sophie; Prunier, Jonathan; Thien, Bruno; Lemarchand, Damien; Pierret, Marie-Claire; Chabaux, François

    2011-12-01

    The recent chemical dynamics of a podzolic forest soil section (from the Strengbach watershed, France) was investigated using U- and Th-series nuclides. Analyses of ( 238U), ( 230Th), ( 226Ra), ( 232Th), ( 228Ra) and ( 228Th) activities in the soil particles, the seepage waters, and the mature leaves of the beech trees growing on this soil were performed by TIMS or gamma spectrometry. The simultaneous analysis of the different soil ( sl) compartments allows to demonstrate that a preferential Th leaching over Ra must be assumed to explain the ( 226Ra/ 230Th), ( 228Ra/ 232Th) and ( 228Th/ 228Ra) disequilibria recorded in the soil particles. The overall Ra- and Th- transfer schemes are entirely consistent with the prevailing acido-complexolysis weathering mechanism in podzols. Using a continuous open-system leaching model, the ( 226Ra/ 230Th) and ( 228Ra/ 232Th) disequilibria measured in the different soil layers enable dating of the contemporary processes occurring in this soil. In this way, we have determined that a preferential Th-leaching from the shallow Ah horizon, due to a strong complexation with organic colloids, began fairly recently (18 years ago at most). The continual increase in pH recorded in precipitations over the last 20 years is assumed to be the cause of this enhanced organic complexation. A lower soil horizon (50-60 cm) is also affected by preferential Th leaching, though lasting over several centuries at least, with a much smaller leaching rate. The migration of Th isotopes through this soil section might hence be used as a tracer for the organic colloids migration and the induced radioactive disequilibria demonstrate to be useful for assessing the colloidal migration kinetics in a forested soil. Ra and Th isotopic ratios also appear to be valuable tracers of some mineral-water-plant interactions occurring in soil. The ( 228Ra/ 226Ra) ratio enables discrimination of the Ra flux originating from leaf degradation from that originating from mineral

  7. 231Pa systematics in postglacial volcanic rocks from Iceland

    NASA Astrophysics Data System (ADS)

    Turner, Simon; Kokfelt, Thomas; Hoernle, Kaj; Lundstrom, Craig; Hauff, Folkmar

    2016-07-01

    Several recent studies have highlighted the potential of combined 238U-230Th and 235U-231Pa systematics to constrain upwelling rates and the role of recycled mafic lithologies in mantle plume-derived basalts. Accordingly, we present measurements of the 231Pa concentrations from 26 mafic volcanic rocks from Iceland, including off-axis basalts from the Snaefellsnes Peninsula, to complement previously published 238U-230Th-226Ra data. 231Pa concentrations vary from 27 to 624 fg/g and (231Pa/235U) ratios from 1.12 to 2.11 with the exception of one anomalous sample from the Southeast Rift which has a 231Pa deficit with (231Pa/235U) = 0.86. An important new result is that basalts from the Southeast Rift and the Snaefellsnes Peninsula define a trend at relatively low (231Pa/235U) for a given (230Th/238U) ratio. Many of the remaining samples fall in or around the global field for ocean island basalts but those from the Mid-Iceland Belt and the Southwest Rift/Reykjanes Peninsula extend to higher (231Pa/235U) ratios at a given (230Th/238U), similar to mid-ocean ridge basalts. In principle, these lavas could result from melting of peridotite at lower pressures. However, there is no reason to suspect that the Mid-Iceland Belt and the Southwest Rift lavas reflect shallower melting than elsewhere in Iceland. In our preferred model, these lavas reflect melting of garnet peridotite whereas those from the Southeast Rift and the Snaefellsnes Peninsula contain a significant contribution (up to 20%) of melt from garnet pyroxenite. This is consistent with incompatible trace element and radiogenic isotope evidence for recycled oceanic crust in these lavas. There is increasing agreement that the displacement of ocean island basalts to lower (231Pa/235U) ratios at a given (230Th/238U), compared to mid-ocean ridge basalts, reflects the role of recycled mafic lithologies such as garnet pyroxenite as well as higher average pressures of melting. It now seems likely that this interpretation may

  8. Melt generation beneath Arctic Ridges: Implications from U decay series disequilibria in the Mohns, Knipovich, and Gakkel Ridges

    NASA Astrophysics Data System (ADS)

    Elkins, L. J.; Sims, K. W. W.; Prytulak, J.; Blichert-Toft, J.; Elliott, T.; Blusztajn, J.; Fretzdorff, S.; Reagan, M.; Haase, K.; Humphris, S.; Schilling, J.-G.

    2014-02-01

    We present new 238U-230Th-226Ra-210Pb, 235U-231Pa, and Nd, Sr, Hf, and Pb isotope data for the slow- to ultraslow-spreading Mohns, Knipovich, and Gakkel Ridges. Combined with previous work, our data from the Arctic Ridges cover the full range of axial depths from the deep northernmost Gakkel Ridge shallowing upwards to the Knipovich, Mohns, and Kolbeinsey Ridges north of Iceland. Age-constrained samples from the Mohns and Knipovich Ridges have (230Th/238U) activity ratios ranging from 1.165 to 1.30 and 1.101 to 1.225, respectively. The high 230Th excesses of Kolbeinsey, Mohns, and Knipovich mid-ocean ridge basalts (MORB) are erupted from ridges producing relatively thin (Mohns, Knipovich) to thick (Kolbeinsey) oceanic crust with evidence for sources ranging from mostly peridotite (Kolbeinsey) to eclogite-rich mantle (Mohns, Knipovich). Age-constrained lavas from 85°E on the Gakkel Ridge, on the other hand, overlie little to no crust and range from small (˜5%) 230Th excesses to small 238U excesses (˜5%). The strong negative correlation between (230Th/238U) values vs. axial ridge depth among Arctic ridge basalts is controlled not only by solidus depth influence on 238U-230Th disequilibria, but also by variations in mantle source lithology and depth to the base of the lithosphere, which is expected to vary at ultra-slow spreading ridges. Small 231Pa excesses (65% excess) in age-constrained basalts support the presence of eclogite in the mantle source for this region. Conversely, the ultraslow-spreading Gakkel Ridge basalts are homogeneous, with Sr, Nd, and Hf radiogenic isotopic signatures indicative of a long time-averaged depleted mantle source. The Gakkel samples have minimum (226Ra/230Th) ratios ranging from 3.07 to 3.65 ± 3%, which lie along and extend the global negative correlation between 226Ra and 230Th excesses observed in MORB. The new 230Th-226Ra data support a model for global MORB production in which deep melts record interaction with shallower

  9. 238U-230Th equilibrium in arc magmas and implications for the time scales of mantle metasomatism

    NASA Astrophysics Data System (ADS)

    Reubi, Olivier; Sims, Kenneth W. W.; Bourdon, Bernard

    2014-04-01

    Large excesses of 238U and 226Ra relative to 230Th characterize many arc magmas and are commonly interpreted to represent recent addition of slab-derived fluid to the mantle wedge beneath the arc. A significant proportion of arc magmas are, however, in 238U-230Th radioactive equilibrium. This is generally thought to result from “buffering” of the young slab fluid U-series signal by a sediment component in secular equilibrium. Here we present new 238U-230Th-226Ra and 235U-231Pa measurements for historic andesites from Volcán de Colima, Mexico. In all lavas (230Th/238U) are in equilibrium, whereas (231Pa/235U) and (226Ra/230Th) are significantly greater than one. These data demonstrate that arc magmas with (230Th/238U) equilibrium can have significant 231Pa and 226Ra excesses, precluding ageing of the magmas in the crust as the cause of 230Th/238U equilibrium. Quantitative modeling of metasomatic and melting processes further indicates that addition of sediment melts to a depleted mantle wedge produces significant 230Th excesses and that 238U excesses induced by recent addition of fluids derived from the altered oceanic crust are not sufficient to compensate these 230Th excesses. U-series activity ratios in Colima magmas are best explained by models in which the metasomatised mantle returns to secular equilibrium before melting, implying a time lag ⩾350 kyr, with subsequent production of 231Pa and 226Ra excesses by in-growth during melting rather than by addition of slab fluids. Investigation of a global compilation of U-series data in arc magma indicates that our model proposed for Colima applies to most arc magmas in or near (230Th-238U) equilibrium. The time lag between mantle metasomatism and melting appears to vary between hundreds years to more than 350 kyr in subduction zones. We posit that the absence of U/Th elemental fractionation during melting of arc sources in (230Th/238U) equilibrium reflects a higher fO2 compared to MORB sources that yield

  10. ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target.

    PubMed

    Nelson, Peter T; Jicha, Gregory A; Wang, Wang-Xia; Ighodaro, Eseosa; Artiushin, Sergey; Nichols, Colin G; Fardo, David W

    2015-11-01

    The ABCC9 gene and its polypeptide product, SUR2, are increasingly implicated in human neurologic disease, including prevalent diseases of the aged brain. SUR2 proteins are a component of the ATP-sensitive potassium ("KATP") channel, a metabolic sensor for stress and/or hypoxia that has been shown to change in aging. The KATP channel also helps regulate the neurovascular unit. Most brain cell types express SUR2, including neurons, astrocytes, oligodendrocytes, microglia, vascular smooth muscle, pericytes, and endothelial cells. Thus it is not surprising that ABCC9 gene variants are associated with risk for human brain diseases. For example, Cantu syndrome is a result of ABCC9 mutations; we discuss neurologic manifestations of this genetic syndrome. More common brain disorders linked to ABCC9 gene variants include hippocampal sclerosis of aging (HS-Aging), sleep disorders, and depression. HS-Aging is a prevalent neurological disease with pathologic features of both neurodegenerative (aberrant TDP-43) and cerebrovascular (arteriolosclerosis) disease. As to potential therapeutic intervention, the human pharmacopeia features both SUR2 agonists and antagonists, so ABCC9/SUR2 may provide a "druggable target", relevant perhaps to both HS-Aging and Alzheimer's disease. We conclude that more work is required to better understand the roles of ABCC9/SUR2 in the human brain during health and disease conditions.

  11. Sur8 mediates tumorigenesis and metastasis in colorectal cancer

    PubMed Central

    Lee, Young-Mi; Kaduwal, Saluja; Lee, Kug Hwa; Park, Jong-Chan; Jeong, Woo-Jeong; Choi, Kang-Yell

    2016-01-01

    Sur8, a scaffold protein of the Ras pathway, interacts with Ras and Raf and modulates the Ras-extracellular signal-regulated kinase (ERK) pathway. Here we show that Sur8 is overexpressed in established human colorectal cancer (CRC) cell lines and CRC patient tissues. Moreover, Sur8 expression is increased during liver metastasis in CRC patients. Sur8 knockdown decreases ERK and Akt activities in CRC cell lines, regardless of their K-Ras, B-Raf or PI3K mutation status. Overexpression or knockdown of Sur8 increases or decreases, respectively, the proliferation or transformation of CRC cell lines. Sur8 knockdown attenuates the migration and invasion of HCT116 CRC cells. Subcutaneous or orthotopic injection of HCT116 cells harboring a doxycycline (Dox)-mediated Sur8 knockdown system in nude mice resulted in decreased tumorigenic potential and inhibited the liver metastatic potential of HCT116 cells. Taken together, our data support the role of Sur8 as a promoter of tumorigenesis and liver metastasis in CRC through its modulation of the Ras-ERK and PI3K-Akt signaling pathways. PMID:27469030

  12. Sur8 mediates tumorigenesis and metastasis in colorectal cancer.

    PubMed

    Lee, Young-Mi; Kaduwal, Saluja; Lee, Kug Hwa; Park, Jong-Chan; Jeong, Woo-Jeong; Choi, Kang-Yell

    2016-01-01

    Sur8, a scaffold protein of the Ras pathway, interacts with Ras and Raf and modulates the Ras-extracellular signal-regulated kinase (ERK) pathway. Here we show that Sur8 is overexpressed in established human colorectal cancer (CRC) cell lines and CRC patient tissues. Moreover, Sur8 expression is increased during liver metastasis in CRC patients. Sur8 knockdown decreases ERK and Akt activities in CRC cell lines, regardless of their K-Ras, B-Raf or PI3K mutation status. Overexpression or knockdown of Sur8 increases or decreases, respectively, the proliferation or transformation of CRC cell lines. Sur8 knockdown attenuates the migration and invasion of HCT116 CRC cells. Subcutaneous or orthotopic injection of HCT116 cells harboring a doxycycline (Dox)-mediated Sur8 knockdown system in nude mice resulted in decreased tumorigenic potential and inhibited the liver metastatic potential of HCT116 cells. Taken together, our data support the role of Sur8 as a promoter of tumorigenesis and liver metastasis in CRC through its modulation of the Ras-ERK and PI3K-Akt signaling pathways. PMID:27469030

  13. Adolescence et pornographie sur la toile

    PubMed Central

    Haza, Marion

    2012-01-01

    Dans cet article, nous abordons la question de l’accès à la pornographie sur Internet par les adolescents. Nous déclinons plusieurs facettes de ces rencontres: la rencontre «fortuite», quand les adolescents sont confrontés à des images intempestives, des publicités ou spams avec des contenus pornographiques; la rencontre «spectatrice», quand les adolescents cherchent activement des vidéos ou photos mettant en scène la sexualité; et enfin la rencontre «actrice», quand les adolescents se mettent en scène eux-mêmes, seuls ou à plusieurs, de façon pornographique sur le Net. A partir d’exemple, nous réfléchissons aux enjeux de ces rencontres virtuelles précoces de la sexualité adulte par rapport au développement adolescent et à la représentation de leur propre sexualité en construction. PMID:22876261

  14. Lithiase géante sur enterocystoplastie

    PubMed Central

    Elmortaji, Khalid; Elomri, Ghassane; Bennani, Saad; Rabii, Redouane; Aboutaib, Rachid; Meziane, Fethi

    2014-01-01

    La formation des lithiases est une complication fréquente des entérocystoplasties après cystectomie radicale pour tumeur de vessie infiltrante. Le délai d'apparition dépend des facteurs de risque favorisants notamment les infections urinaires. Néanmoins la survenue de lithiase géante sur néovessie reste exceptionnelle, seulement 5 cas ont été rapportés dans la littérature. Nous rapportons dans ce travail, le cas d'une lithiase géante compliquant une entérocystoplastie chez un malade suivi pour tumeur de vessie infiltrante. PMID:25932070

  15. AirMSPI PODEX Big Sur Ellipsoid Images

    Atmospheric Science Data Center

    2013-12-11

    ... AirMSPI Browse Images from the PODEX 2013 Campaign   Big Sur target 02/03/2013 Ellipsoid-projected   Select ...   Version number   For more information, see the  Data Product Specifications (DPS) ...

  16. Lignes directrices canadiennes sur la rhinosinusite chronique

    PubMed Central

    Kaplan, Alan

    2013-01-01

    Résumé Objectif Présenter un résumé clinique des lignes directrices canadiennes sur la rhinosinusite chronique (RSC) qui comporte des recommandations pertinentes aux médecins de famille. Qualité des données Les auteurs des lignes directrices ont effectué une recherche documentaire systématique dans la littérature médicale et ont rédigé une ébauche de recommandations. Une cote a été donnée à la fois en fonction de la fiabilité des données probantes et de la solidité des recommandations. On a sollicité les commentaires d’experts en contenu de l’extérieur, ainsi que l’aval des sociétés médicales (Association pour la microbiologie médicale et l’infectiologie Canada, Société canadienne d’allergie et d’immunologie clinique, Canadian Society of Otolaryngology—Head and Neck Surgery, Association canadienne des médecins d’urgence et Regroupement canadien des médecins de famille en santé respiratoire). Message principal Le diagnostic d’une RSC se fonde sur le type et la durée des symptômes et une constatation objective d’une inflammation de la muqueuse nasale ou des sinus paranasaux. La rhinosinusite chronique est catégorisée en fonction de la présence ou de l’absence de polypes nasaux et cette distinction entraîne des différences dans le traitement. On traite la rhinosinusite chronique avec polypes nasaux au moyen de corticostéroïdes par voie intranasale. Des antibiotiques sont recommandés quand les symptômes indiquent une infection (douleur ou purulence). Pour une RSC sans polypes nasaux, on recommande des corticostéroïdes par voie intranasale et des antibiotiques de deuxième ligne (par ex. combinaisons amoxicilline–acide clavulanique ou fluoroquinolones à activité accrue contre Gram positif). Une irrigation avec une solution saline, des stéroïdes par voie orale et des tests d’allergies pourraient être appropriées. Si le patient ne répond pas au traitement, il faudrait envisager d

  17. Fires Burning near Big Sur, California

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Fires near Big Sur, Calif., continued to burn unchecked when the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument on NASA's Terra satellite captured this image on Sunday, June 29. In Northern California alone, fires have consumed more than 346,000 acres.At least 18,000 people have deployed to attempt to extinguish or control the flames. Air quality as far away as San Francisco has been adversely impacted by the dense clouds of smoke and ash blowing towards the northwest. The satellite image combines a natural color portrayal of the landscape with thermal infrared data showing the active burning areas in red. The dark area in the lower right is a previous forest fire.

    ASTER is one of five Earth-observing instruments launched December 18, 1999, on NASA's Terra satellite. The instrument was built by Japan's Ministry of Economy, Trade and Industry. A joint U.S./Japan science team is responsible for validation and calibration of the instrument and the data products.

    The broad spectral coverage and high spectral resolution of ASTER provides scientists in numerous disciplines with critical information for surface mapping, and monitoring of dynamic conditions and temporal change. Example applications are: monitoring glacial advances and retreats; monitoring potentially active volcanoes; identifying crop stress; determining cloud morphology and physical properties; wetlands evaluation; thermal pollution monitoring; coral reef degradation; surface temperature mapping of soils and geology; and measuring surface heat balance.

    The U.S. science team is located at NASA's Jet Propulsion Laboratory, Pasadena, Calif. The Terra mission is part of NASA's Science Mission Directorate.

    Size: 35.4 by 57 kilometers (21.9 by 34.2 miles) Location: 36.1 degrees North latitude, 121.6 degrees West longitude Orientation: North at top Image Data: ASTER bands 3, 2, and 1 Original Data Resolution: 15 meters (49 feet) Dates Acquired: June 29

  18. Effets de la formation sur la violence conjugale

    PubMed Central

    Zaher, Eman; Keogh, Kelly; Ratnapalan, Savithiri

    2014-01-01

    interventions éducatives à multiples facettes prenaient la forme d’ateliers interactifs, d’apprentissage sur le web et de formation expérientielle. Une autre étude utilisait des discussions de groupes témoins et de la formation et a permis de constater une amélioration dans le signalement de la violence conjugale par les médecins. Les 2 autres études ont relevé une meilleure perception par les médecins en pratique de leur confiance en eux à l’aide d’apprentissage par problèmes en ligne. Conclusion Il a été difficile de déterminer quelle stratégie pédagogique était la plus efficace étant donné que les interventions éducatives et les mesures des résultats variaient entre les études choisies. De brèves interventions pour les médecins en formation postdoctorale amélioraient les connaissances mais ne semblaient pas influencer les comportements. La formation en ligne sous forme d’apprentissage par problèmes améliorait les perceptions des médecins en pratique, leurs connaissances et leurs habiletés quant à la prise en charge de la violence conjugale. La formation des médecins combinée à des interventions de soutien de la part du système semblait bénéfique aux victimes de violence conjugale et augmentait le nombre de demandes de consultations auprès des ressources de soutien à leur intention.

  19. Internet Discussion Groups.

    ERIC Educational Resources Information Center

    Bull, Glen; Bull, Gina; Sigmon, Tim

    1997-01-01

    Discusses newsgroups, listservs, and Web-based discussion groups. Highlights include major categories of international USENET discussion groups; newsgroups versus mailing lists; newsreaders; news servers; newsgroup subscriptions; newsgroups versus Web discussion groups; linking newsgroups, mailing lists, and the Web; and setting up a news host. A…

  20. Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues

    PubMed Central

    Principalli, Maria A; Dupuis, Julien P; Moreau, Christophe J; Vivaudou, Michel; Revilloud, Jean

    2015-01-01

    ATP-sensitive potassium channels (K-ATP channels) play a key role in adjusting the membrane potential to the metabolic state of cells. They result from the unique combination of two proteins: the sulfonylurea receptor (SUR), an ATP-binding cassette (ABC) protein, and the inward rectifier K+ channel Kir6.2. Both subunits associate to form a heterooctamer (4 SUR/4 Kir6.2). SUR modulates channel gating in response to the binding of nucleotides or drugs and Kir6.2 conducts potassium ions. The activity of K-ATP channels varies with their localization. In pancreatic β-cells, SUR1/Kir6.2 channels are partly active at rest while in cardiomyocytes SUR2A/Kir6.2 channels are mostly closed. This divergence of function could be related to differences in the interaction of SUR1 and SUR2A with Kir6.2. Three residues (E1305, I1310, L1313) located in the linker region between transmembrane domain 2 and nucleotide-binding domain 2 of SUR2A were previously found to be involved in the activation pathway linking binding of openers onto SUR2A and channel opening. To determine the role of the equivalent residues in the SUR1 isoform, we designed chimeras between SUR1 and the ABC transporter multidrug resistance-associated protein 1 (MRP1), and used patch clamp recordings on Xenopus oocytes to assess the functionality of SUR1/MRP1 chimeric K-ATP channels. Our results reveal that the same residues in SUR1 and SUR2A are involved in the functional association with Kir6.2, but they display unexpected side-chain specificities which could account for the contrasted properties of pancreatic and cardiac K-ATP channels. PMID:26416970

  1. Random assembly of SUR subunits in K(ATP) channel complexes.

    PubMed

    Cheng, Wayland W L; Tong, Ailing; Flagg, Thomas P; Nichols, Colin G

    2008-01-01

    Sulfonylurea receptors (SURs) associate with Kir6.x subunits to form tetradimeric K(ATP) channel complexes. SUR1 and SUR2 confer differential channel sensitivities to nucleotides and pharmacological agents, and are expressed in specific, but overlapping, tissues. This raises the question of whether these different SUR subtypes can assemble in the same channel complex and generate channels with hybrid properties. To test this, we engineered dimeric constructs of wild type or N160D mutant Kir6.2 fused to SUR1 or SUR2A. Dimeric fusions formed functional, ATP-sensitive, channels. Coexpression of weakly rectifying SUR1-Kir6.2 (WTF-1) with strongly rectifying SUR1-Kir6.2[N160D] (NDF-1) in COSm6 cells results in mixed subunit complexes that exhibit unique rectification properties. Coexpression of NDF-1 and SUR2A-Kir6.2 (WTF-2) results in similar complex rectification, reflecting the presence of SUR1- and SUR2A-containing dimers in the same channel. The data demonstrate clearly that SUR1 and SUR2A subunits associate randomly, and suggest that heteromeric channels will occur in native tissues. PMID:18690055

  2. Impact de la preparation des anodes crues et des conditions de cuisson sur la fissuration dans des anodes denses

    NASA Astrophysics Data System (ADS)

    Amrani, Salah

    La fabrication de l'aluminium est realisee dans une cellule d'electrolyse, et cette operation utilise des anodes en carbone. L'evaluation de la qualite de ces anodes reste indispensable avant leur utilisation. La presence des fissures dans les anodes provoque une perturbation du procede l'electrolyse et une diminution de sa performance. Ce projet a ete entrepris pour determiner l'impact des differents parametres de procedes de fabrication des anodes sur la fissuration des anodes denses. Ces parametres incluent ceux de la fabrication des anodes crues, des proprietes des matieres premieres et de la cuisson. Une recherche bibliographique a ete effectuee sur tous les aspects de la fissuration des anodes en carbone pour compiler les travaux anterieurs. Une methodologie detaillee a ete mise au point pour faciliter le deroulement des travaux et atteindre les objectifs vises. La majorite de ce document est reservee pour la discussion des resultats obtenus au laboratoire de l'UQAC et au niveau industriel. Concernant les etudes realisees a l'UQAC, une partie des travaux experimentaux est reservee a la recherche des differents mecanismes de fissuration dans les anodes denses utilisees dans l'industrie d'aluminium. L'approche etait d'abord basee sur la caracterisation qualitative du mecanisme de la fissuration en surface et en profondeur. Puis, une caracterisation quantitative a ete realisee pour la determination de la distribution de la largeur de la fissure sur toute sa longueur, ainsi que le pourcentage de sa surface par rapport a la surface totale de l'echantillon. Cette etude a ete realisee par le biais de la technique d'analyse d'image utilisee pour caracteriser la fissuration d'un echantillon d'anode cuite. L'analyse surfacique et en profondeur de cet echantillon a permis de voir clairement la formation des fissures sur une grande partie de la surface analysee. L'autre partie des travaux est basee sur la caracterisation des defauts dans des echantillons d'anodes crues

  3. Finding the SurPriSe: A Case Study of a Faculty Learning Community

    ERIC Educational Resources Information Center

    Michel, Roberta M.

    2014-01-01

    This article details a faculty learning community (FLC) that started in 2009 on the campus of a Midwestern University and has evolved into an interdisciplinary research, teaching and social community of practice and learning called SurPriSe. SurPriSe is an acronym that reflects the interest area of the FLC; Sur for surveillance, Pri for privacy,…

  4. Learning through Discussions

    ERIC Educational Resources Information Center

    Ellis, Robert A.; Calvo, Rafael; Levy, David; Tan, Kelvin

    2004-01-01

    Students studying a third-year e-commerce subject experienced face-to-face and online discussions as an important part of their learning experience. The quality of the students' experiences of learning through those discussions is investigated in this study. This study uses qualitative approaches to investigate the variation in the students'…

  5. The Use of Discussion.

    ERIC Educational Resources Information Center

    Brunner, Edmund deS.; And Others

    Research on the use of discussion in adult education has been largely concerned with comparing it with the use of other instructional techniques and with measuring opinion change. Many studies, such as Kurt Lewin's study of food habits, have compared the effectiveness of group discussion as contrasted with lecture in changing opinions and…

  6. Framing Evolution Discussion Intellectually

    ERIC Educational Resources Information Center

    Oliveira, Alandeom W.; Cook, Kristin; Buck, Gayle A.

    2011-01-01

    This study examines how a first-year biology teacher facilitates a series of whole-class discussions about evolution during the implementation of a problem-based unit. A communicative theoretical perspective is adopted wherein evolution discussions are viewed as social events that the teacher can frame intellectually (i.e., present or organize as…

  7. Leading Classroom Discussions

    ERIC Educational Resources Information Center

    Gonzalez, Gloriana; DeJarnette, Anna F.

    2013-01-01

    Classroom discourse is a valuable teaching and learning tool. Discussions allow students to improve their communication and reasoning skills in mathematics and help teachers assess students' understanding of mathematical ideas. To get the greatest benefit from discussion, teachers must elicit student thinking, listen carefully to their ideas,…

  8. Le point sur les amas de galaxies

    NASA Astrophysics Data System (ADS)

    Pierre, M.

    galaxies jouent donc un rôle de premier plan dans toute étude cosmologique et par conséquent, sont indispensables à notre compréhension globale de l'univers. Dans l'introduction générale, nous détaillons cet aspect fondamental en montrant comment l'étude des amas peut contribuer à contraindre les scénarios cosmologiques. Une fois le contexte scientifique délimité, les chapitres suivants s'attachent à présenter les diverses propriétés des amas et leur évolution cosmique observée dans diverses longueurs d'onde principalement dans les domaines visible (galaxies), X (gaz) et radio (gaz et particules). Nous verrons que l'étude détaillée d'un amas implique celle de l'interaction entre ses différentes composantes et est un passage obligé pour remonter au paramètre ultime (ou premier) qu'est sa masse. Loin d'être un détour ennuyeux, ceci sera l'occasion d'aborder des phénomènes physiques extrêmement variés tel l'aspect multi-phases du milieu intra-amas, les sursauts de formation d'étoiles et l'évolution morphologique des galaxies capturées par les amas, ou bien encore, l'interaction entre le plasma intra-amas et les particules relativistes accélérées lors de la fusion entre deux amas. Bien sûr, pour chaque longueur d'onde, nous ne manquerons pas de décrire simplement les techniques d'observation et d'analyse mises en oeuvre ; celles-ci sont particulièrement intéressantes dans le cas de l'instrumentation spatiale. Nous terminerons en présentant des projets d'observatoires pour l'horizon 2010 et leur impact prévu sur l'étude des amas de galaxies.

  9. Basic poster discussion: summary.

    PubMed

    Widdicombe, John

    2011-06-01

    Twelve posters were presented in the section on Basic Research. They were discussed in a session chaired by Paul Davenport (Gainesville, US) and Marian Kollarik (Boston, US), with each poster presenter first briefly describing his/her poster.

  10. Etude des effets du martelage repetitif sur les contraintes residuelles

    NASA Astrophysics Data System (ADS)

    Hacini, Lyes

    L'assemblage par soudage peut engendrer des contraintes residuelles. Ces contraintes provoquent des fissurations prematurees et un raccourcissement de la duree de vie des composants. Dans ce contexte, le martelage robotise est utilise pour relaxer ces contraintes residuelles. Trois volets sont presentes: le premier est l'evaluation des effets des impacts unitaires repetes sur le champ de contraintes developpe dans des plaques d'acier inoxydable austenitique 304L vierges ou contenant des contraintes residuelles initiales. Dans la deuxieme partie de ce projet, le martelage est applique grace au robot SCOMPI. Les contraintes residuelles induites et relaxees par martelage sont ensuite mesurees par la methode des contours, qui a ete adaptee a cet effet. Dans la troisieme partie, le martelage est modelise par la methode des elements finis. Un modele axisymetrique developpe grace au logiciel ANSYS permet de simuler des impacts repetes d'un marteau elastique sur une plaque ayant un comportement elastoplastique.

  11. Promoting Lively Literature Discussion

    ERIC Educational Resources Information Center

    Gritter, Kristine

    2011-01-01

    When students create personal connections with literature during whole-class discussion, they make sense both of text and of their life experiences. In this article, the author shares tips that help students make text-to-self, text-to-world, and text-to-text connections. She offers classroom examples to illustrate how conversations that encourage…

  12. Writing a Discussion.

    ERIC Educational Resources Information Center

    Smith, Sue; And Others

    A unit used in an Australian school to teach English-as-a-Second-Language (ESL) students how to write a discussion is described. The 3-week unit was planned and implemented jointly by an ESL resource teacher, class teacher, and teacher librarian. The class was divided into three heterogeneous groups, two of which were observed for this study and…

  13. Framing Discussions about Teaching

    ERIC Educational Resources Information Center

    Danielson, Charlotte

    2015-01-01

    Danielson's Framework for Teaching has provided a common language for discussions of teaching practice for almost 20 years. Many educators love the Framework's comprehensiveness; they find the specific language to be useful as they strive to improve their practice. For other educators, however, the Framework's 22 components and 76 smaller elements…

  14. Discussions That Drive Democracy

    ERIC Educational Resources Information Center

    Hess, Diana

    2011-01-01

    Adults in the United States have been migrating to ideologically homogenous communities, a phenomenon that researchers have called "the big sort." Thus, the need for young Americans to engage in civil discussion of controversial issues has never been greater. Public schools are an ideal place to undo the big sort because controversial issues fit…

  15. Experiential environmental learning: A case study of innovative pedagogy in Baja Sur, Mexico

    NASA Astrophysics Data System (ADS)

    Schneller, Andrew Jon

    This mixed methods case study describes an innovative two-semester middle school environmental learning course that departs from traditional Mexican expository pedagogy through the incorporation of experiential and service learning. This research takes place in a small middle school in Pescadero, Baja California Sur, Mexico. The research approach utilized in the study adds to the handful of studies in this cross-disciplinary field by employing quantitative methodologies to measure course outcomes on student environmental knowledge, perceptions, and actions, while simultaneously qualitatively describing the behavioral, educational, environmental, and social experiences of students. This research employs Dewey's theories of experience---as well as those of more contemporary authenticity theorists---in order to identify the philosophies that advocate incorporating experiential pedagogy within the curriculum. Implications for Mexican educational policy, practical pedagogical applications, and theory are discussed.

  16. Clinicians Discuss Diaper Dermatitis.

    PubMed

    Brucker, Mary; McGuire, Stephanie; Merrill, Lisa; Rossing, Francine; Sayaseng, Kammi

    2015-01-01

    Diaper dermatitis in infants is commonly seen by clinicians in both primary care and acute care settings. The condition can cause significant discomfort for infants and distress for their parents and caregivers. Nursing for Women's Health convened a group of nursing clinicians who work in a variety of settings to discuss the issues and challenges related to preventing and treating diaper dermatitis in both healthy term newborns and premature newborns.

  17. DISCUSSION ON MENINGITIS

    PubMed Central

    1929-01-01

    (1) Meningitis: two groups of cases. (2) A method of washing out the subarachnoid space in cases of septic meningitis secondary to infection of the ear. (3) Discussion on the value of maintaining a positive pressure of the cerebrospinal fluid when operating on a septic region communicating with the subarachnoid space. (4) Leaking cerebrospinal fluid from the region of the ear: operative treatment. PMID:19986899

  18. Summaries of group discussions

    NASA Technical Reports Server (NTRS)

    Jensen, L. D.

    1972-01-01

    Group discussions following the presentations of reports on the remote sensing of Chesapeake Bay resources are presented. The parameters to be investigated by the remote sensors and the specifications of the sensors are described. Specific sensors for obtaining data on various aspects of the ecology are identified. Recommendations for establishing a data bank and additional efforts to obtain increased understanding of the ecology are submitted.

  19. Effets des electrons secondaires sur l'ADN

    NASA Astrophysics Data System (ADS)

    Boudaiffa, Badia

    Les interactions des electrons de basse energie (EBE) representent un element important en sciences des radiations, particulierement, les sequences se produisant immediatement apres l'interaction de la radiation ionisante avec le milieu biologique. Il est bien connu que lorsque ces radiations deposent leur energie dans la cellule, elles produisent un grand nombre d'electrons secondaires (4 x 104/MeV), qui sont crees le long de la trace avec des energies cinetiques initiales bien inferieures a 20 eV. Cependant, il n'y a jamais eu de mesures directes demontrant l'interaction de ces electrons de tres basse energie avec l'ADN, du principalement aux difficultes experimentales imposees par la complexite du milieu biologique. Dans notre laboratoire, les dernieres annees ont ete consacrees a l'etude des phenomenes fondamentaux induits par impact des EBE sur differentes molecules simples (e.g., N2, CO, O2, H2O, NO, C2H 4, C6H6, C2H12) et quelques molecules complexes dans leur phase solide. D'autres travaux effectues recemment sur des bases de l'ADN et des oligonucleotides ont montre que les EBE produisent des bris moleculaires sur les biomolecules. Ces travaux nous ont permis d'elaborer des techniques pour mettre en evidence et comprendre les interactions fondamentales des EBE avec des molecules d'interet biologique, afin d'atteindre notre objectif majeur d'etudier l'effet direct de ces particules sur la molecule d'ADN. Les techniques de sciences des surfaces developpees et utilisees dans les etudes precitees peuvent etre etendues et combinees avec des methodes classiques de biologie pour etudier les dommages de l'ADN induits par l'impact des EBE. Nos experiences ont montre l'efficacite des electrons de 3--20 eV a induire des coupures simple et double brins dans l'ADN. Pour des energies inferieures a 15 eV, ces coupures sont induites par la localisation temporaire d'un electron sur une unite moleculaire de l'ADN, ce qui engendre la formation d'un ion negatif transitoire

  20. Cryptic young zircon and young plagioclase in the Kaharoa Rhyolite, Tarawera, New Zealand: Implications for crystal recycling in magmatic systems

    NASA Astrophysics Data System (ADS)

    Klemetti, E. W.; Cooper, K. M.

    2007-12-01

    We measured in-situ 238U-230Th zircon and bulk plagioclase 238U-230Th-226Ra disequilibria in rhyolite lava and tephra from the ~1315 AD Kaharoa eruption of Tarawera Volcano, New Zealand in order to constrain its history of chemical evolution. These data suggest that zircon records a protracted history (10s of kyr) whereas plagioclase is dominantly young (few kyr), but both phases crystallize up to the eruption. The Kaharoa eruptive period at Tarawera consists of ~2.5 km3 of crystal-rich rhyolite (74-75 wt% silica) lava and ~5 km3 of coeval tephra deposits, making it the largest silicic eruption in New Zealand in the last 1,000 years. 238U-230Th disequilibria measurements of zircon determined via SHRIMP-RG analyses produce an array of ages, with three main populations: (1) within error of eruption age; (2) 15-80 k.y.; (3) 100-175 k.y. Very few analyzed zircon fall within error of eruption age and little difference is seen in the age distribution of zircon between the lava and tephra. In contrast, 238U-230Th and 230Th-226Ra plagioclase ages appear to be within error of eruption age however this age is complicated zircon inclusions in the plagioclase. This contamination by zircon is seen in the 238U-230Th disequilibria and trace element data, where the addition of zircon pushes the bulk plagioclase separate towards more U-enriched values and high Zr values. However, the (230Th)/(232Th) ratios for the separates are the same as the whole rock values, indicating that any zircon in the bulk separate must be young (eruption age). This finding is also borne out in 230Th-226Ra disequilibria, where zero-age zircon contamination is reflected in increased (230Th)/[Ba] with no change in (226Ra)/[Ba]. In both cases, as little as 1 ppm of zero-age zircon contamination is needed to create these patterns. This signal of young plagioclase and zircon growth is in contrast to the protracted history seen in the SHRIMP-RG zircon data. This suggests that young zircon growth in the Kaharoa

  1. U-series Isotope Constraints on Rhyolite Generation at South Sister and Newberry Volcanoes, Central Oregon

    NASA Astrophysics Data System (ADS)

    Mitchell, E. C.; Asmerom, Y.

    2011-12-01

    The central Oregon Cascades are unique due to an abundance of mafic post-glacial volcanism found nowhere else within the arc, as well as an exceptional volume of rhyolite, which is typically restricted to rear-arc centers in the rest of the Cascades. Within central Oregon, South Sister and Newberry, a large stratovolcano and major rear-arc center respectively, have both erupted bimodal basalt-rhyolite suites during the Holocene, with compositional gaps at ˜ 56-72 wt.% SiO2. The mafic lavas are generally accepted to be mantle-derived melts, variously modified by AFC processes. However, the origin of the felsic rocks is more contentious. Numerous studies have focused on South Sister, and have invoked a variety of processes to explain the bimodal suite there, including assimilation-fractional crystallization from a mafic parent, and partial to complete melting of a variety of crustal lithologies ranging from mafic amphibolite to granite. The Holocene obsidian flows of Newberry volcano have received less attention, although they have also been interpreted as discrete, small volume melts of a granitic source. In order to place further constraints on the processes involved in their genesis, we have obtained 238U-230Th-226Ra, 87Sr/86Sr, and 143Nd/144Nd whole rock data for three South Sister rhyolites and two Newberry obsidians. The South Sister rhyolites have homogeneous 87Sr/86Sr and 143Nd/144Nd ratios of ˜ 0.7036 and 0.51286 respectively. In contrast, the two Newberry obsidians have distinct 87Sr/86Sr (0.70366 vs. 0.70385) and 143Nd/144Nd (0.512879 vs. 0.512848) ratios. These values range from the same as, to slightly more radiogenic than, corresponding ratios measured in mafic lavas from the same region. The South Sister rhyolites are in (230Th/238U) secular equilibrium, while the Newberry obsidians have small 230Th excesses of 4 and 7% at (230Th/232Th) of 1.20. All samples are in (226Ra/230Th) secular equilibrium implying > ˜ 8000 years since the pair were last

  2. Assessing Natural Radionuclide Migration in the Legacy Tailings of Uranium Production

    NASA Astrophysics Data System (ADS)

    Bondarenko, G.; Koliabina, I.; Marinich, O.

    2011-12-01

    - 230Th - 226Ra - 210Pb decay chain, typical for closed systems, has been disturbed during selective chemical uranium extraction from the parent ore. We calculated the migration of 210Pb, assuming constant 226Ra activity. The results of these calculations show that over 50 years, ~18% of the initial (unknown) 210Pb(0) activity was removed. If we assume removal of 226Ra decay products will continue at the current level, we expect the future annual activity loss of 210Pb to be about 0.36% per year, or 0.072 Bq/g. Assuming the examined core sample is representative of all 12 million tons of tails, the total annual activity loss is estimated to be ~1012 Bq/year. These results allow us to conclude that the loss of activity from the tailing pit by water migration is mainly associated with the 226Ra decay products: 222Rn, 210Pb, 210Po.
    Activity ratios, Dnieper tailings

  3. Empowerment: a conceptual discussion.

    PubMed

    Tengland, Per-Anders

    2008-06-01

    The concept of 'empowerment' is used frequently in a number of professional areas, from psychotherapy to social work. But even if the same term is used, it is not always clear if the concept denotes the same goals or the same practice in these various fields. The purpose of this paper is to clarify the discussion and to find a plausible and useful definition of the concept that is suitable for work in various professions. Several suggestions are discussed in the paper, for example control over life or health, autonomy, ability, self-efficacy, self-esteem, and freedom, and it is concluded that there are two plausible complementary uses, one as a goal and one as a process or approach. Empowerment as a goal is to have control over the determinants of one's quality of life, and empowerment as a process is to create a professional relation where the client or community takes control over the change process, determining both the goals of this process and the means to use.

  4. Medical Physics Panel Discussion

    NASA Astrophysics Data System (ADS)

    Guèye, Paul; Avery, Steven; Baird, Richard; Soares, Christopher; Amols, Howard; Tripuraneni, Prabhakar; Majewski, Stan; Weisenberger, Drew

    2006-03-01

    The panel discussion will explore opportunities and vistas in medical physics research and practice, medical imaging, teaching medical physics to undergraduates, and medical physics curricula as a recruiting tool for physics departments. Panel members consist of representatives from NSBP (Paul Guèye and Steven Avery), NIH/NIBIB (Richard Baird), NIST (Christopher Soares), AAPM (Howard Amols), ASTRO (Prabhakar Tripuraneni), and Jefferson Lab (Stan Majewski and Drew Weisenberger). Medical Physicists are part of Departments of Radiation Oncology at hospitals and medical centers. The field of medical physics includes radiation therapy physics, medical diagnostic and imaging physics, nuclear medicine physics, and medical radiation safety. It also ranges from basic researcher (at college institutions, industries, and laboratories) to applications in clinical environments.

  5. Endothelial SUR-8 Acts in an ERK-Independent Pathway During Atrioventricular Cushion Development

    PubMed Central

    Yi, Jing; Chen, Muyun; Wu, Xiaohui; Yang, Xiao; Xu, Tian; Zhuang, Yuan; Han, Min; Xu, Rener

    2010-01-01

    SUR-8, a conserved leucine-rich repeats protein, was first identified as a positive regulator of Ras pathway in Caenorhabditis elegans. Biochemical studies indicated that SUR-8 interacts with Ras and Raf, leading to the elevated ERK activity. However, the physiological role of SUR-8 during mammalian development remains unclear. Here we found that germline deletion of SUR-8 in mice resulted in early embryonic lethality. Inactivated SUR-8 specifically in mouse endothelial cells (ECs) revealed that SUR-8 is essential for embryonic heart development. SUR-8 deficiency in ECs resulted in late embryonic lethality, and the mutant mice displayed multiple cardiac defects. The reduced endothelial-mesenchymal transformation (EMT) and the reduced mesenchyme proliferation phase were observed in the atrioventricular canal (AVC) within the mutant hearts, leading to the formation of hypoplastic endocardial cushions. However, ERK activation did not appear to be affected in mutant ECs, suggesting that SUR-8 may act in an ERK-independent pathway to regulate AVC development. Developmental Dynamics 239:2005–2013, 2010 © 2010 Wiley-Liss, Inc. PMID:20549726

  6. From Bretonneau to therapeutic antibodies, from specificity to specific remedies, Saint-Cyr-Sur-Loire, France, November 19, 2012

    PubMed Central

    Marchand, Claire; Nouat, Romaric; Watier, Hervé

    2013-01-01

    Held on November 19, 2012 in Saint-Cyr-sur-Loire, France, the symposium “From Bretonneau to therapeutic antibodies, from specificity to specific remedies” focused on the historical development of antibodies as therapeutics, with an emphasis on the seminal work of the French physician Pierre-Fidèle Bretonneau (1778–1862). The morning session was devoted to discussion of the evolution of the concept of specificity in medicine, which started with an epistemological definition. The contributions of Bretonneau to the emergence of the concept of specificity, notably with his studies on diphtheria, and the subsequent development of antidiphtheric serotherapy in Europe during the period 1894–1898 were then presented in detail. The afternoon session began with a presentation on the role of French physiologists during the years 1860–1890 in establishing the basic concepts of specific immunity and the principles of serotherapy. The history of antivenom serotherapy, particularly its discovery by Césaire Phisalix, and the development of antilymphocyte globulins as successful transplantation drugs were then discussed. The symposium ended with the inauguration of a stele representing Bretonneau, who lived in Saint-Cyr-sur-Loire and died 150 y ago. PMID:23924799

  7. Lignes directrices simplifiées sur les lipides

    PubMed Central

    Allan, G. Michael; Lindblad, Adrienne J.; Comeau, Ann; Coppola, John; Hudson, Brianne; Mannarino, Marco; McMinis, Cindy; Padwal, Raj; Schelstraete, Christine; Zarnke, Kelly; Garrison, Scott; Cotton, Candra; Korownyk, Christina; McCormack, James; Nickel, Sharon; Kolber, Michael R.

    2015-01-01

    Résumé Objectif Produire un guide de pratique clinique comportant une approche simplifiée à la prévention primaire des maladies cardiovasculaires (MCV), en insistant sur l’estimation du risque de MCV et la prise en charge des profils lipidiques à l’intention des cliniciens de soins primaires et leurs équipes; nous avons recherché la contribution de professionnels des soins primaires qui n’avaient que peu ou pas de conflits d’intérêts et nous nous sommes concentrés sur les données probantes de la plus haute qualité accessibles. Méthodes Neuf professionnels de la santé (4 médecins de famille, 2 internistes, 1 infirmière praticienne, 1 infirmière autorisée et 1 pharmacienne) et 1 membre non votant (pharmacienne gestionnaire de projet) formaient le comité principal appelé le Lipid Pathway Committee (le comité). La sélection des membres s’est fondée sur la profession, le milieu de pratique et son emplacement. Les membres ont divulgué tous leurs conflits d’intérêts potentiels ou réels. Le processus d’élaboration des lignes directrices était itératif et s’appuyait sur des affichages en ligne, une révision détaillée des données probantes, des réunions par téléphone et en ligne. Le comité a cerné 12 questions prioritaires à répondre. Le groupe de révision des données probantes a répondu à ces questions. À la suite d’un examen des réponses, les principales recommandations ont été formulées par consensus du comité. Nous avons produit une ébauche des lignes directrices qui a ensuite été peaufinée, distribuée à un groupe de cliniciens (médecins de famille, autres spécialistes, pharmaciens, infirmières et infirmières praticiennes) et à des patients pour obtenir de la rétroaction, la réviser en conséquence et le comité l’a ensuite finalisée. Recommandations Des recommandations sont présentées concernant le dépistage et les analyses, les évaluations du risque, le suivi, de même que le r

  8. Structure of thermotoga maritima stationary phase survival protein SurE : a novel acid phosphatase.

    SciTech Connect

    Zhang, R.-G; Skarina, T.; Katz, J. E.; Khachatryan, A; Vyas, S.; Arrowsmith, C. H.; Clarke, S.; Edwards, A.; Joachimiak, A.; Savchenko, A.; Biosciences Division; Univ. of Toronto; Univ. of California; Clinical Genomics Centre /Proteomics, Univ. Health Network

    2001-11-01

    Background: The rpoS, nlpD, pcm, and surE genes are among many whose expression is induced during the stationary phase of bacterial growth. rpoS codes for the stationary-phase RNA polymerase {sigma} subunit, and nlpD codes for a lipoprotein. The pcm gene product repairs damaged proteins by converting the atypical isoaspartyl residues back to L-aspartyls. The physiological and biochemical functions of surE are unknown, but its importance in stress is supported by the duplication of the surE gene in E. coli subjected to high-temperature growth. The pcm and surE genes are highly conserved in bacteria, archaea, and plants. Results: The structure of SurE from Thermotoga maritima was determined at 2.0 Angstroms. The SurE monomer is composed of two domains; a conserved N-terminal domain, a Rossman fold, and a C-terminal oligomerization domain, a new fold. Monomers form a dimer that assembles into a tetramer. Biochemical analysis suggests that SurE is an acid phosphatase, with an optimum pH of 5.5-6.2. The active site was identified in the N-terminal domain through analysis of conserved residues. Structure-based site-directed point mutations abolished phosphatase activity. T. maritima SurE intra- and intersubunit salt bridges were identified that may explain the SurE thermostability. Conclusions: The structure of SurE provided information about the protein's fold, oligomeric state, and active site. The protein possessed magnesium-dependent acid phosphatase activity, but the physiologically relevant substrate(s) remains to be identified. The importance of three of the assigned active site residues in catalysis was confirmed by site-directed mutagenesis.

  9. Human Cloning: Let's Discuss It.

    ERIC Educational Resources Information Center

    Taras, Loretta; Stavroulakis, Anthea M.; Ortiz, Mary T.

    1999-01-01

    Describes experiences with holding discussions on cloning at a variety of levels in undergraduate biology courses. Discusses teaching methods used and student reactions to the discussions. Contains 12 references. (WRM)

  10. Let's Discuss: Teaching Students about Discussions

    ERIC Educational Resources Information Center

    Brank, Eve; Wylie, Lindsey

    2013-01-01

    Research consistently demonstrates the benefits of employing classroom discussions; however, there has been less attention given to teaching students about discussions. The current research compared 2 advanced social psychology courses: 1 without (control) and 1 with (experimental) a week devoted to learning about and discussing discussions.…

  11. Discussion.

    ERIC Educational Resources Information Center

    Higgs, Philip

    2003-01-01

    Author argues that the philosophical movement known as postmodernism seriously undermined the notion that truth can be at all objective and that truth depends entirely on democratic consensus. Addresses Davon-Galle's criticism of the author's assertions and explains that the certainty that Davon-Galle seeks is not to be found in philosophy or any…

  12. Discussion

    NASA Astrophysics Data System (ADS)

    Crawford, K.

    Presenter, T. P. Grazulis, private consultant [Grazulis et al., this volume, advances in tornado climatology, hazards, and risk assessment since Tornado Symposium II]. (C. Anderson, North Carolina State University.) At one time, I lived in Wisconsin and used to consider tornado climatology there. I noticed some very strange reporting, also. There were a number of counties along the Lake Michigan shore that showed no reported tornadoes from 1915 to 1950. Did you find something like this as well?

  13. Discussion.

    ERIC Educational Resources Information Center

    Davson-Galle, Peter

    2003-01-01

    Explains Philip Higgs' post modern pluralist thought by reaction to the monolithic rigidities of the decreed dogma of his country's (South Africa) past. Author argues that Higgs has overreacted and has become over tolerant of diversity of thought and that intellectual endeavors should be relativised to particular intellectual parochial…

  14. SUR1-Associated Mechanisms Are Not Involved in Ischemic Optic Neuropathy 1 Day Post-Injury

    PubMed Central

    Nicholson, James D.; Guo, Yan; Bernstein, Steven L.

    2016-01-01

    Ischemia-reperfusion injury after central nervous system (CNS) injury presents a major health care challenge with few promising treatments. Recently, it has become possible to reduce edema after CNS injury by antagonizing a sulfonylurea receptor 1 (SUR1) regulated ion channel expressed after injury. SUR1 upregulation after injury is a necessary precondition for the formation of this channel, and has been implicated in white matter injury after clinical spinal cord trauma. Glibenclamide, an SUR1 antagonist, appears to have neuroprotective effect against cerebral stroke in an open-label small clinical trial and great effectiveness in reducing damage after varied experimental CNS injury models. Despite its importance in CNS injuries, SUR1 upregulation appears to play no part in rodent anterior ischemic optic neuropathy (rAION) injury as tested by real-time PCR and immunohistochemical staining of rAION-injured rat optic nerve (ON). Furthermore, the SUR1 antagonist glibenclamide administered immediately after rAION injury provided no protection to proximal ON microvasculature 1 day post-injury but may reduce optic nerve head edema in a manner unrelated to ON SUR1 expression. Our results suggest that there may be fundamental differences between rAION optic nerve ischemia and other CNS white matter injuries where SUR1 appears to play a role. PMID:27560494

  15. SUR1-Associated Mechanisms Are Not Involved in Ischemic Optic Neuropathy 1 Day Post-Injury.

    PubMed

    Nicholson, James D; Guo, Yan; Bernstein, Steven L

    2016-01-01

    Ischemia-reperfusion injury after central nervous system (CNS) injury presents a major health care challenge with few promising treatments. Recently, it has become possible to reduce edema after CNS injury by antagonizing a sulfonylurea receptor 1 (SUR1) regulated ion channel expressed after injury. SUR1 upregulation after injury is a necessary precondition for the formation of this channel, and has been implicated in white matter injury after clinical spinal cord trauma. Glibenclamide, an SUR1 antagonist, appears to have neuroprotective effect against cerebral stroke in an open-label small clinical trial and great effectiveness in reducing damage after varied experimental CNS injury models. Despite its importance in CNS injuries, SUR1 upregulation appears to play no part in rodent anterior ischemic optic neuropathy (rAION) injury as tested by real-time PCR and immunohistochemical staining of rAION-injured rat optic nerve (ON). Furthermore, the SUR1 antagonist glibenclamide administered immediately after rAION injury provided no protection to proximal ON microvasculature 1 day post-injury but may reduce optic nerve head edema in a manner unrelated to ON SUR1 expression. Our results suggest that there may be fundamental differences between rAION optic nerve ischemia and other CNS white matter injuries where SUR1 appears to play a role.

  16. SUR1-Associated Mechanisms Are Not Involved in Ischemic Optic Neuropathy 1 Day Post-Injury.

    PubMed

    Nicholson, James D; Guo, Yan; Bernstein, Steven L

    2016-01-01

    Ischemia-reperfusion injury after central nervous system (CNS) injury presents a major health care challenge with few promising treatments. Recently, it has become possible to reduce edema after CNS injury by antagonizing a sulfonylurea receptor 1 (SUR1) regulated ion channel expressed after injury. SUR1 upregulation after injury is a necessary precondition for the formation of this channel, and has been implicated in white matter injury after clinical spinal cord trauma. Glibenclamide, an SUR1 antagonist, appears to have neuroprotective effect against cerebral stroke in an open-label small clinical trial and great effectiveness in reducing damage after varied experimental CNS injury models. Despite its importance in CNS injuries, SUR1 upregulation appears to play no part in rodent anterior ischemic optic neuropathy (rAION) injury as tested by real-time PCR and immunohistochemical staining of rAION-injured rat optic nerve (ON). Furthermore, the SUR1 antagonist glibenclamide administered immediately after rAION injury provided no protection to proximal ON microvasculature 1 day post-injury but may reduce optic nerve head edema in a manner unrelated to ON SUR1 expression. Our results suggest that there may be fundamental differences between rAION optic nerve ischemia and other CNS white matter injuries where SUR1 appears to play a role. PMID:27560494

  17. [Marine algae of Baja California Sur, Mexico: nutritional value].

    PubMed

    Carrillo Domínguez, Silvia; Casas Valdez, Margarita; Ramos Ramos, Felipe; Pérez-Gil, Fernando; Sánchez Rodríguez, Ignacio

    2002-12-01

    The Baja California Peninsula is one of the richest regions of seaweed resources in México. The objective of this study was to determine the chemical composition of some marine algae species of Baja California Sur, with an economical potential due to their abundance and distribution, and to promote their use as food for human consumption and animal feeding. The algae studied were Green (Ulva spp., Enteromorpha intestinalis, Caulerpa sertularoides, Bryopsis hypnoides), Red (Laurencia johnstonii, Spyridia filamentosa, Hypnea valentiae) and Brown (Sargassum herporizum, S. sinicola, Padina durvillaei, Hydroclathrus clathrathus, Colpomenia sinuosa). The algae were dried and ground before analysis. In general, the results showed that algae had a protein level less than 11%, except L. johnstonii with 18% and low energy content. The ether extract content was lower than 1%. However, the algae were a good source of carbohydrates and inorganic matter.

  18. Introduction to Small Group Discussion.

    ERIC Educational Resources Information Center

    Millar, Dan Pyle

    To bring educational research into focus with tested classroom practice, this booklet provides an introduction to small group discussion. The theory and research section discusses the importance of small group discussion, characteristics of small group discussions, group attraction based on Maslow's hierarchy of basic human needs, group decision…

  19. Enquete sur les aspects toxicologiques de la phytotherapie utilisee par un herboriste à Fes, Maroc

    PubMed Central

    Zeggwagh, Ali Amine; Lahlou, Younes; Bousliman, Yassir

    2013-01-01

    Introduction Dans le but d'étudier l'aspect toxicologique des plantes médicinales utilisées en médecine traditionnelle, une étude ethnobotanique a été réalisée à la ville de Fès au centre du Maroc. Méthodes Ont été inclus dans l'étude tous les patients ayant bénéficié d'une prescription par l'herboriste de plantes à visée thérapeutique. La discussion de nos résultats s'est faite sur la base d'une revue de la littérature avec identification des principales plantes toxiques utilisées en phytothérapie au Maroc. L'approche bibliographique a permis de compléter les informations. Résultats L'âge moyen des patients traités par des plantes (38 femmes, 32 hommes) était de 35 ± 18 ans. L'enquête ethnobotanique à révélé que la majorité des plantes médicinales étaient utilisées contre les affections urinaires (21%), suivi des maladies de l'appareil digestif (19.6%) et des maladies rhumatologiques (18.2%). Le nombre de plantes prescrits par l'herboriste a été de 53 dont 5 sont potentiellement toxiques. L'identification taxonomique des plantes prescrites a recensé 30 familles dont les plus représentées sont les Lamiaceae (23.33%), les Apiaceae (13,33%) et les Asteraceae (10%). La prescription des plantes considérées comme toxiques a concerné 7,1% des consultants traités par les plantes médicinales. Aucune complication inhérente aux plantes prescrites n'a été déplorée. Conclusion Malgré les résultats encourageants de notre enquête sur le compte de la phytothérapie, la pratique de la phytothérapie est laissée à la vulgarisation et à l'oubli scientifique, législatif et universitaire. PMID:23734270

  20. 46 CFR 7.135 - Point Sur, CA to Cape Blanco, OR.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... shore. (e) A line drawn from the northwestern tip of Tomales Point to latitude 38°15.1′ N. longitude 123... 46 Shipping 1 2014-10-01 2014-10-01 false Point Sur, CA to Cape Blanco, OR. 7.135 Section 7.135... Pacific Coast § 7.135 Point Sur, CA to Cape Blanco, OR. (a) A line drawn from Monterey Harbor Light “6”...

  1. 46 CFR 7.135 - Point Sur, CA to Cape Blanco, OR.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... shore. (e) A line drawn from the northwestern tip of Tomales Point to latitude 38°15.1′ N. longitude 123... 46 Shipping 1 2012-10-01 2012-10-01 false Point Sur, CA to Cape Blanco, OR. 7.135 Section 7.135... Pacific Coast § 7.135 Point Sur, CA to Cape Blanco, OR. (a) A line drawn from Monterey Harbor Light “6”...

  2. 46 CFR 7.135 - Point Sur, CA to Cape Blanco, OR.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... shore. (e) A line drawn from the northwestern tip of Tomales Point to latitude 38°15.1′ N. longitude 123... 46 Shipping 1 2011-10-01 2011-10-01 false Point Sur, CA to Cape Blanco, OR. 7.135 Section 7.135... Pacific Coast § 7.135 Point Sur, CA to Cape Blanco, OR. (a) A line drawn from Monterey Harbor Light “6”...

  3. 46 CFR 7.135 - Point Sur, CA to Cape Blanco, OR.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... shore. (e) A line drawn from the northwestern tip of Tomales Point to latitude 38°15.1′ N. longitude 123... 46 Shipping 1 2013-10-01 2013-10-01 false Point Sur, CA to Cape Blanco, OR. 7.135 Section 7.135... Pacific Coast § 7.135 Point Sur, CA to Cape Blanco, OR. (a) A line drawn from Monterey Harbor Light “6”...

  4. 46 CFR 7.130 - Point Conception, CA to Point Sur, CA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Point Conception, CA to Point Sur, CA. 7.130 Section 7.130 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.130 Point Conception, CA to Point Sur, CA. (a) A line drawn from the southernmost extremity of Fossil Point at longitude...

  5. 46 CFR 7.135 - Point Sur, CA to Cape Blanco, OR.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Point Sur, CA to Cape Blanco, OR. 7.135 Section 7.135 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY PROCEDURES APPLICABLE TO THE PUBLIC BOUNDARY LINES Pacific Coast § 7.135 Point Sur, CA to Cape Blanco, OR. (a) A line drawn from Monterey Harbor Light “6” to latitude 36°36.5′ N. longitude...

  6. Modelisations des effets de surface sur les jets horizontaux subsoniques d'hydrogene et de methane

    NASA Astrophysics Data System (ADS)

    Gomez, Luis Fernando

    Le developpement des codes et de normes bases sur une methodologie scientifique requiert la capacite de predire l'etendue inflammable de deversements gazeux d'hydrogene sous differentes conditions. Des etudes anterieures ont deja etabli des modeles bases sur les lois de conservation de la mecanique des fluides basees sur des correlations experimentales qui permettent de predire la decroissance de la concentration et de la vitesse d'un gaz le long de l'axe d'un jet libre vertical. Cette etude s'interesse aux effets de proximite a une surface horizontale parallele sur un jet turbulent. Nous nous interessons a son impact sur l'etendue du champ de la concentration et sur l'enveloppe inflammable en particulier. Cette etude est comparative : l'hydrogene est compare au methane. Ceci permet de degager l'influence des effets de difference de la densite sur le comportement du jet, et de comparer le comportement de l'hydrogene aux correlations experimentales, qui ont ete essentiellement etablies pour le methane. Un modele decrivant l'evolution spatio-temporelle du champ de concentration du gaz dilue est propose, base sur la mecanique des fluides computationnelle. Cette approche permet de varier systematiquement les conditions aux frontieres (proximite du jet a la surface, par exemple) et de connaitre en detail les proprietes de l'ecoulement. Le modele est implemente dans le code de simulations par volumes finis de FLUENT. Les resultats des simulations sont compares avec les lois de similitudes decoulant de la theorie des jets d'ecoulements turbulents libres ainsi qu'avec les resultats experimentaux disponibles. L'effet de la difference des masses molaires des constituantes du jet et des constituantes du milieu de dispersion est egalement etudie dans le contexte du comportement d'echelle de la region developpee du jet.

  7. A Discussion of Population Invariance

    ERIC Educational Resources Information Center

    Brennan, Robert L.

    2008-01-01

    The discussion here covers five articles that are linked in the sense that they all treat population invariance. This discussion of population invariance is a somewhat broader treatment of the subject than simply a discussion of these five articles. In particular, occasional reference is made to publications other than those in this issue. The…

  8. Carcinome hépatocellulaire non fibrolamellaire sur foie sain

    PubMed Central

    Bouomrani, Salem; Kilani, Ichrak; Nouma, Hanène; Slama, Alaeddine; Beji, Maher

    2014-01-01

    Le carcinome hépatocellulaire (CHC) survient le plus souvent sur foie de cirrhose. Sa survenue sur un foie sain est exceptionnelle et pose un véritable défit diagnostique pour le clinicien. Nous rapportons l'observation d'un patient de 53 ans, sans antécédents pathologiques notables qui fût admis pour exploration d'une douleur de l'hypochondre droit évoluant depuis quelques mois avec une exacerbation récente, associée à un amaigrissement important et une altération de l’état général. L'examen clinique notait une hépatomégalie ferme et douloureuse. L’échographie abdominale montrait une masse hétérogène du secteur latéral droit du foie faisant 10 cm de grand axe. La TDM abdominale montrait une masse tissulaire, hétérogène, à vascularisation artérielle importante, mesurant 10 cm de diamètre et occupant le secteur latéral droit du foie. Cette tumeur comprime la branche portale droite sans signes d'extension. Il n'y avait pas d'adénopathie ni d’épanchement intra abdominal. La ponction biopsique écho-guidée avait conclu à un CHC non fibrolamellaire. Le bilan biologique, en particulier les transaminases, le taux de prothrombine, l’électrophorèse des protéines sanguine et l'alpha foeto-protéine, était sans anomalies. Les sérologies de l'hépatites virales B et C ainsi que la recherche des auto anticorps spécifiques des hépatites auto immunes et le bilan cuprique étaient aussi négatives. Vue l’âge, le stade avancé de la tumeur et l'altération de l’état général la conduite thérapeutique était de s'abstenir. PMID:25419293

  9. Ubiquitous Discussion Forum: Introducing Mobile Phones and Voice Discussion into a Web Discussion Forum

    ERIC Educational Resources Information Center

    Wei, Fu-Hsiang; Chen, Gwo-Dong; Wang, Chin-Yeh; Li, Liang-Yi

    2007-01-01

    Web-based discussion forums enable users to share knowledge in straightforward and popular platforms. However, discussion forums have several problems, such as the lack of immediate delivery and response, the heavily text-based medium, inability to hear expressions of voice and the heuristically created discussion topics which can impede the…

  10. Sur Lago area, Venezuela: Three dimensional integrated seismic interpretation

    SciTech Connect

    Growcott, A.; McIan, A.; Ramirez, R. )

    1993-02-01

    In 1988, 550 square km of 3D seismic data were acquired in the Sur Del Lago area. The aims of the survey were (1) To better define structures already identified from the existing 1 [times] 1 km 2D seismic grid at the level of potential Cretaceous limestone reservoirs and (2) To further study the prospectivity of potential structural and stratigraphic traps within the Tertiary section. Detailed interpretation of the 3D survey using an interactive workstation led to an improved structural definition at the Cogollo limestone level and the identification of fault related inversion lineaments and basement related Cretaceous limestone structures. Based upon the new seismic interpretation a 4 well exploration project was planned. The new program commenced with the drilling of exploration well SLA-7-IX in 1991 which proved commercial amounts of hydrocarbons in the western part of the area. Detailed information collected from the exploration wells includes a comprehensive electric log suite, ditch cuttings and vertical seismic profiles. The information is being used as detailed lithological, stratigraphic and seismic data input for velocity modeling, ray trace modeling, seismic attribute analysis, and reservoir characterization software in order to further understand the structural and stratigraphic potential of the area.

  11. Chemical Kinetics Laboratory Discussion Worksheet.

    PubMed

    Demoin, Dustin Wayne; Jurisson, Silvia S

    2013-09-10

    A laboratory discussion worksheet and its answer key provide instructors and students a discussion model to further the students' understanding of chemical kinetics. This discussion worksheet includes a section for students to augment their previous knowledge about chemical kinetics measurements, an initial check on students' understanding of basic concepts, a group participation model where students work on solving complex-conceptual problems, and a conclusion to help students connect this discussion to their laboratory or lecture class. Additionally, the worksheet has a detailed solution to a more advanced problem to help students understand how the concepts they have put together relate to problems they will encounter during later formal assessments.

  12. Acquiring Knowledge from Asynchronous Discussion

    ERIC Educational Resources Information Center

    Teo, Yiong Hwee; Webster, Len

    2008-01-01

    This article discusses a study which was designed to explore how online scaffolding can be incorporated to support knowledge acquisition in asynchronous discussion. A group of Singapore preservice teachers engaged in collaborative critiquing of videos before they embarked on their video projects to illustrate what constitutes good and bad video…

  13. Teacher Flexibility in Mathematical Discussion

    ERIC Educational Resources Information Center

    Leikin, Roza; Dinur, Sariga

    2007-01-01

    The significance of discussion in mathematics classes has been prominently debated in the research literature. Different studies have stressed the importance of teacher flexibility in orchestrating the discussion. We introduce an operational definition of teacher flexibility. In a case study with one secondary-school mathematics teacher, we…

  14. Conséquences des nouvelles formes de commande sur les matériaux de l'isolation statorique

    NASA Astrophysics Data System (ADS)

    Bellomo, J. P.; Lebey, Th.; Peltier, Fr.; Oraison, J. M.

    1997-05-01

    Use of inverter drive for rotating machines speed control leads to the application of new stress on stator insulation materials. The integrity of these materials under such stresses has therefore to be studied. Thanks to specially equipped motor, the different voltage shapes have been identified. Very short rise time fronts, large overvoltages and high oscillation frequencies are obtained. These voltages are then reproduced on laboratory samples (Polyethylene Terephtalate). The main result is the existence of trapped surface charges related both to the rise front value and to the existence of polar mechanisms in the material bulk. The consequences of this surface charge existence on the reliability of a real system are then discussed. L'utilisation de nouvelles formes de commande pour les machines à courant alternatif se traduit par l'apparition d'un nouveau type de contraintes sur les matériaux de l'isolation statorique. L'étude de leur comportement sous l'action de ce type de contraintes revêt un intérêt tout particulier pour la validation et la stabilité de ces systèmes dans le temps. Nous présentons, tout d'abord, ces différentes formes de tension identifiées à l'aide d'un moteur spécialement instrumenté. L'existence de fronts de tension très élevés, de surtensions importantes (jusqu'à 500V) et d'oscillations hautes fréquences (2MHz), est mise en évidence. La reproduction de ces contraintes en laboratoire sur des échantillons de polyesters (PolyÉthylène Térephthalate) permet alors de déterminer l'influence des formes de tension carrées sur les propriétés intrinsèques du matériau. Elle se traduit par l'existence d'une charge piégée en surface du diélectrique. Cette charge superficielle est associée, d'une part à l'existence de phénomènes de relaxation dans les matériaux étudiés et d'autre part à la valeur des fronts de tension appliqués. Pour finir, les conséquences possibles de l'existence de ces charges superficielles

  15. Socrates, discussion and moral education

    NASA Astrophysics Data System (ADS)

    Rembert, Ron B.

    1995-01-01

    For Socrates, as he appears in Plato's dialogues, the process of discussion is essential for preparing human beings to lead a moral life. Only through discussion, Socrates maintains, can we be led to an understanding of such concepts as wisdom, courage and justice. The author of this article believes that the Socratic notion of the moral value of discussion is still valid. In support of this view, he examines two recent works: Dialogues on Moral Education by John Wilson and Barbara Cowell, and Moral Education, Secular and Religious by John L. Elias. Finally, the author suggests how the Socratic concept of dialogue might be used in moral education today.

  16. SurR regulates hydrogen production in Pyrococcus furiosus by a sulfur-dependent redox switch

    PubMed Central

    Yang, Hua; Lipscomb, Gina L.; Keese, Annette M.; Schut, Gerrit J.; Thomm, Michael; Adams, Michael W. W.; Wang, Bi Cheng; Scott, Robert A.

    2010-01-01

    SUMMARY We present structural and biochemical evidence for a redox switch in the archaeal transcriptional regulator SurR of Pyrococcus furiosus, a hyperthermophilic anaerobe. P. furiosus produces H2 during fermentation, but undergoes a metabolic shift to produce H2S when elemental sulfur (S0) becomes available. Changes in gene expression occur within minutes of S0 addition, and the majority of these S0-responsive genes are regulatory targets of SurR, a key regulator involved in primary S0 response. SurR was shown in vitro to have dual functionality, activating transcription of some of these genes, notably the hydrogenase operons, and repressing others, including a gene encoding sulfur reductase. This work demonstrates via biochemical and structural evidence that the activity of SurR is modulated by cysteine residues in a CxxC motif that constitute a redox switch. Oxidation of the switch with S0 inhibits sequence-specific DNA binding by SurR, leading to deactivation of genes related to H2 production and derepression of genes involved in S0 metabolism. PMID:20598080

  17. Discussion-Induced Attitude Polarization

    ERIC Educational Resources Information Center

    Myers, David G.

    1975-01-01

    Two experiments examined the hypothesis that the average of group members' responses following group discussion will generally be more extreme in the same direction as the average of individual pregroup preferences. (Author/MLF)

  18. Animating Geometry Discussions with Flexigons.

    ERIC Educational Resources Information Center

    McClintock, Ruth

    1994-01-01

    Presents activities with 10- and 4-straw flexigons, an object created by stringing together lengths of plastic drinking straws with nylon fishing line. Discusses several geometric theorems that can be demonstrated with flexigons. (MKR)

  19. Three-phase Discussion Sessions.

    ERIC Educational Resources Information Center

    Karr, M. C.; And Others

    1988-01-01

    Describes the procedures, organizational pattern and design of basic soils course used by teaching assistants. Cites studies which support small-group discussion for promoting higher levels of intellectual functioning. Presents tables showing survey evaluation results of this method. (RT)

  20. Taking account of quality. Discussion.

    PubMed

    Baker, S B; Cassel, C K; Coye, M J; Denham, C R; Foley, M E; Grotting, J B; Millenson, M L; Risk, R R

    2001-01-01

    Another report from the Institute of Medicine in March 2001 has joined a large body of literature documenting serious quality and safety problems. Eight health care leaders discuss ways in which organizations can reduce medical errors and improve patient outcomes.

  1. The Activity of Escherichia coli Chaperone SurA Is Regulated by Conformational Changes Involving a Parvulin Domain

    PubMed Central

    Soltes, Garner R.; Schwalm, Jaclyn; Ricci, Dante P.

    2016-01-01

    ABSTRACT The periplasmic chaperone SurA is critical for the biogenesis of outer membrane proteins (OMPs) and, thus, the maintenance of membrane integrity in Escherichia coli. The activity of this modular chaperone has been attributed to a core chaperone module, with only minor importance assigned to the two SurA peptidyl-prolyl isomerase (PPIase) domains. In this work, we used synthetic phenotypes and covalent tethering to demonstrate that the activity of SurA is regulated by its PPIase domains and, furthermore, that its activity is correlated with the conformational state of the chaperone. When combined with mutations in the β-barrel assembly machine (BAM), SurA mutations resulting in deletion of the second parvulin domain (P2) inhibit OMP assembly, suggesting that P2 is involved in the regulation of SurA. The first parvulin domain (P1) potentiates this autoinhibition, as mutations that covalently tether the P1 domain to the core chaperone module severely impair OMP assembly. Furthermore, these inhibitory mutations negate the suppression of and biochemically stabilize the protein specified by a well-characterized gain-of-function mutation in P1, demonstrating that SurA cycles between distinct conformational and functional states during the OMP assembly process. IMPORTANCE This work reveals the reversible autoinhibition of the SurA chaperone imposed by a heretofore underappreciated parvulin domain. Many β-barrel-associated outer membrane (OM) virulence factors, including the P-pilus and type I fimbriae, rely on SurA for proper assembly; thus, a mechanistic understanding of SurA function and inhibition may facilitate antibiotic intervention against Gram-negative pathogens, such as uropathogenic Escherichia coli, E. coli O157:H7, Shigella, and Salmonella. In addition, SurA is important for the assembly of critical OM biogenesis factors, such as the lipopolysaccharide (LPS) transport machine, suggesting that specific targeting of SurA may provide a useful means to

  2. LGBT Roundtable Discussion: Meet-up and Mentoring Discussion

    NASA Astrophysics Data System (ADS)

    2014-03-01

    The LGBT+ Physicists group welcomes those who identify as gender sexual minorities, as LGBTQQIAAP+, or as allies to participate in a round-table discussion on mentoring physicists. The session will provide an opportunity to learn and discuss successful mentoring strategies at different career stages for physicists in all environments, including academia, industry, etc. Attendees are encouraged to attend a social event to follow the panel to continue to network. Allies are especially welcome at this event to learn how to support and mentor LGBT+ physicists.

  3. Small group discussion: Students perspectives

    PubMed Central

    Annamalai, Nachal; Manivel, Rajajeyakumar; Palanisamy, Rajendran

    2015-01-01

    Context: Various alternative methods are being used in many medical colleges to reinforce didactic lectures in physiology. Small group teaching can take on a variety of different tasks such as problem-solving, role play, discussions, brainstorming, and debate. Research has demonstrated that group discussion promotes greater synthesis and retention of materials. Aims: The aims of this study were to adopt a problem-solving approach by relating basic sciences with the clinical scenario through self-learning. To develop soft skills, to understand principles of group dynamics, and adopt a new teaching learning methodology. Subjects and Methods: Experimental study design was conducted in Phase I 1st year medical students of 2014–2015 batch (n = 120). On the day of the session, the students were grouped into small groups (15 each). The session started with the facilitator starting off the discussion. Feedback forms from five students in each group was taken (n = 40). A five point Likert scale was used ranging from strongly agree to strongly disagree. Data were analyzed using IBM SPSS Statistics for Windows, Version 21.0. Armonk, NY: IBM Corp. Results: Our results show that 70% of the students opined that small group discussion were interactive, friendly, innovative, built interaction between teacher and student. Small group discussion increased their thought process and helped them in better communication. Conclusions: The small group discussion was interactive, friendly, and bridged the gap between the teacher and student. The student's communication skills are also improved. In conclusion, small group discussion is more effective than the traditional teaching methods. PMID:26380202

  4. Availability of safe drinking-water: the answer to cholera outbreak? Nabua, Camarines Sur, Philippines, 2012

    PubMed Central

    de los Reyes, Vikki Carr; Sucaldito, Ma Nemia; Tayag, Enrique

    2015-01-01

    Background In May 2012, there were increasing diarrhoea cases and deaths reported from Nabua, Camarines Sur to the Philippines event-based surveillance system. An investigation was conducted to identify risk factors and determine transmission dynamics. Methods A suspected case was defined as a resident of Nabua with at least three episodes of watery diarrhoea per day from 16 March to 22 June 2012. A confirmed case was defined as a suspected case positive for Vibrio cholerae. An environmental investigation was conducted and rectal swabs and water samples sent to the national reference laboratory for bacterial isolation. A 1:2 case-control study matching for age and sex was conducted. Data were analysed using Epi Info. Results There were 309 suspected cases with two deaths, and the most affected age group was children under five years (45%). Eight cases were positive for Vibrio cholerae Ogawa El Tor and one for Non-01. Water samples were positive for faecal coliforms and Aeromonas caviae. The case-control study showed that cases had a higher odds than controls of using unchlorinated water sources (odds ratio [OR] = 3.6; 95% confidence interval [CI]:1.6–8.5) and having toilets located within 20 m of a septic tank (OR = 2.7; 95% CI: 1.4–5.3). In multivariate analysis, the only significant factor was drinking from piped water (OR = 0.21; 95% CI: 0.09–0.49). Discussion In this cholera outbreak, drinking-water from unchlorinated wells was a significant risk factor. Future cholera control efforts should include not just improving water and sanitation systems but also intensified behaviour change campaigns. PMID:26668761

  5. Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity.

    PubMed

    Mura, Cameron; Katz, Jonathan E; Clarke, Steven G; Eisenberg, David

    2003-03-01

    The survival protein E (SurE) family was discovered by its correlation to stationary phase survival of Escherichia coli and various repair proteins involved in sustaining this and other stress-response phenotypes. In order to better understand this ancient and well-conserved protein family, we have determined the 2.0A resolution crystal structure of SurEalpha from the hyperthermophilic crenarchaeon Pyrobaculum aerophilum (Pae). This first structure of an archaeal SurE reveals significant similarities to and differences from the only other known SurE structure, that from the eubacterium Thermatoga maritima (Tma). Both SurE monomers adopt similar folds; however, unlike the Tma SurE dimer, crystalline Pae SurEalpha is predominantly non-domain swapped. Comparative structural analyses of Tma and Pae SurE suggest conformationally variant regions, such as a hinge loop that may be involved in domain swapping. The putative SurE active site is highly conserved, and implies a model for SurE bound to a potential substrate, guanosine-5'-monophosphate (GMP). Pae SurEalpha has optimal acid phosphatase activity at temperatures above 90 degrees C, and is less specific than Tma SurE in terms of metal ion requirements. Substrate specificity also differs between Pae and Tma SurE, with a more specific recognition of purine nucleotides by the archaeal enzyme. Analyses of the sequences, phylogenetic distribution, and genomic organization of the SurE family reveal examples of genomes encoding multiple surE genes, and suggest that SurE homologs constitute a broad family of enzymes with phosphatase-like activities.

  6. Argumentative Reasoning in Online Discussion.

    ERIC Educational Resources Information Center

    Steinkuehler, Constance A.; Derry, Sharon J.; Levin, Joel R.; Kim, Jong-Baeg

    This study compared the effects of three forms of online instruction on memory, belief change, and argumentation skill. Reading of a pro/con text was followed by: (1) online discussion in pairs compared to reading of the same text followed by two forms of individualized study techniques derived from the cognitive memory literature; (2)…

  7. Black Psychologists Discuss Behavior Modification.

    ERIC Educational Resources Information Center

    Bardo, Harold R.; And Others

    The primary purpose of this paper is to discuss reasons why blacks should be concerned and actively involved with practices in behavior modification. The concern is that as these techniques are refined it becomes more important to be sure blacks should be involved at all levels of the application of these procedures when other blacks are subjects…

  8. Five Discussions on Postsecondary Education.

    ERIC Educational Resources Information Center

    Jobe, E. R., Ed.

    Topics discussed are: (1) student aid and access to postsecondary education (Jack L. Woodward); (2) values in athletics (Grant Dungee); (3) some considerations in planning for postsecondary education (Paul G. Orr); (4) the open university as a challenge for postsecondary education in Mississippi (Cleopatra D. Thompson); and (5) comprehensive…

  9. Learning Discussion Skills Through Games.

    ERIC Educational Resources Information Center

    Stanford, Gene; Stanford, Barbara Dodds

    This book provides a sequence of 10 skill-building games and follow-up activities (beginning with "Getting Acquainted" and ending with "Arriving at a Consensus") designed to give students necessary practice in proper discussion techniques. Fifteen remedial exercises to treat such weaknesses as extreme aggressiveness or a habit of straying from the…

  10. Lively Discussions! Fostering Engaged Reading.

    ERIC Educational Resources Information Center

    Gambrell, Linda B., Ed.; Almasi, Janice F., Ed.

    Offering practical, classroom-based strategies teachers can use to promote literacy development, this book presents many examples of children engaging in discussion activities about narrative and informational text that emphasize collaborating, constructing meaning, and using these different types of texts to arrive at new understandings. Chapters…

  11. Body Art: A Panel Discussion.

    ERIC Educational Resources Information Center

    Surgenor, Peter; And Others

    1997-01-01

    Three camp directors discuss their policies regarding body art and body piercing. Only one director reported a strict policy prohibiting tattoos or body art based on standards that the camp portrays to families. However, all directors enforced policies prohibiting clothing or body art that mentions alcohol, tobacco, drug use, or inappropriate…

  12. Another Discussion about Academic Corruption

    ERIC Educational Resources Information Center

    Changgeng, Li

    2007-01-01

    Academic corruption is a commonplace matter about which all people are clearly aware. However, people often overlook many hidden or latent manifestations of academic corruption. This article discusses eight of these manifestations: indiscriminate use of the academic team spirit, the proliferation of "word games," deliberate attacks on others to…

  13. Linguistic Indexicality in Algebra Discussions

    ERIC Educational Resources Information Center

    Staats, Susan; Batteen, Chris

    2010-01-01

    In discussion-oriented classrooms, students create mathematical ideas through conversations that reflect growing collective knowledge. Linguistic forms known as indexicals assist in the analysis of this collective, negotiated understanding. Indexical words and phrases create meaning through reference to the physical, verbal and ideational context.…

  14. A Study in Structured Discussion.

    ERIC Educational Resources Information Center

    Gutzmer, Willard Ernest

    This study tested the hypothesis that group interaction skill and useful learning occur in a discussion group which is academically structured. A class procedure involving a cognitive map, member skills and roles, and group etiquette was incorporated into a class ("Education and the Contemporary Scene," Fall Quarter, 1968) at the University of…

  15. Group discussion improves lie detection.

    PubMed

    Klein, Nadav; Epley, Nicholas

    2015-06-16

    Groups of individuals can sometimes make more accurate judgments than the average individual could make alone. We tested whether this group advantage extends to lie detection, an exceptionally challenging judgment with accuracy rates rarely exceeding chance. In four experiments, we find that groups are consistently more accurate than individuals in distinguishing truths from lies, an effect that comes primarily from an increased ability to correctly identify when a person is lying. These experiments demonstrate that the group advantage in lie detection comes through the process of group discussion, and is not a product of aggregating individual opinions (a "wisdom-of-crowds" effect) or of altering response biases (such as reducing the "truth bias"). Interventions to improve lie detection typically focus on improving individual judgment, a costly and generally ineffective endeavor. Our findings suggest a cheap and simple synergistic approach of enabling group discussion before rendering a judgment.

  16. Group discussion improves lie detection

    PubMed Central

    Klein, Nadav; Epley, Nicholas

    2015-01-01

    Groups of individuals can sometimes make more accurate judgments than the average individual could make alone. We tested whether this group advantage extends to lie detection, an exceptionally challenging judgment with accuracy rates rarely exceeding chance. In four experiments, we find that groups are consistently more accurate than individuals in distinguishing truths from lies, an effect that comes primarily from an increased ability to correctly identify when a person is lying. These experiments demonstrate that the group advantage in lie detection comes through the process of group discussion, and is not a product of aggregating individual opinions (a “wisdom-of-crowds” effect) or of altering response biases (such as reducing the “truth bias”). Interventions to improve lie detection typically focus on improving individual judgment, a costly and generally ineffective endeavor. Our findings suggest a cheap and simple synergistic approach of enabling group discussion before rendering a judgment. PMID:26015581

  17. Group discussion improves lie detection.

    PubMed

    Klein, Nadav; Epley, Nicholas

    2015-06-16

    Groups of individuals can sometimes make more accurate judgments than the average individual could make alone. We tested whether this group advantage extends to lie detection, an exceptionally challenging judgment with accuracy rates rarely exceeding chance. In four experiments, we find that groups are consistently more accurate than individuals in distinguishing truths from lies, an effect that comes primarily from an increased ability to correctly identify when a person is lying. These experiments demonstrate that the group advantage in lie detection comes through the process of group discussion, and is not a product of aggregating individual opinions (a "wisdom-of-crowds" effect) or of altering response biases (such as reducing the "truth bias"). Interventions to improve lie detection typically focus on improving individual judgment, a costly and generally ineffective endeavor. Our findings suggest a cheap and simple synergistic approach of enabling group discussion before rendering a judgment. PMID:26015581

  18. Discussions on Hypnosis and Schizophrenia.

    PubMed

    Haley, Jay

    2015-01-01

    A classic paper in intellect and argument, this article contains a transcript of a conversation between Jay Haley, John Weakland, and Milton Erickson as they discuss the role of communication in hypnosis and schizophrenia. In 1955, schizophrenia was considered primarily a psychological disorder. Whereas today schizophrenia is mostly considered a biological disorder, this very early, unpublished paper still gives much food for thought and a further glimpse into Haley and Erickson's thinking and intellect at a fervent time in schizophrenia research.

  19. The Classroom as Big Sur: Notes on the Liaison Between Evaluation and Professional Growth

    ERIC Educational Resources Information Center

    Sneeden, Ralph

    2013-01-01

    Bill Frisell's new album ("Big Sur") was heralded with a short documentary about its impulse and inception: Frisell's retreat to an isolated coastal ranch in Central California. In the video, he describes the influence of the place, the dramatic and evocative landscape, and how it ultimately became the subject and theme for the…

  20. Seafloor Rocks and Sediments of the Continental Shelf From Monterey Bay to Point Sur, California

    USGS Publications Warehouse

    Eittreim, Stephen L.; Anima, Roberto J.; Stevenson, Andrew J.; Wong, Florence L.

    2000-01-01

    Introduction Acoustic swath mapping of the greater Monterey Bay area continental shelf from Point Ano Nuevo to Point Sur reveals complex patterns of rock outcrops on the shelf, and coarse sand bodies that occur in distinct depressions on the inner and mid-shelves. This publication portrays the seafloor components in a 36- by 48-inch map sheet at 1:100,000 scale.

  1. Reflections on "Petit Battement sur le Cou de Pied": Is It Still Relevant?

    ERIC Educational Resources Information Center

    Paskevska, Anna

    2007-01-01

    This article presents multiple perspectives of "petit battement sur le cou de pied". These perspectives include historical, biomechanical, and pedagogic points of view. The article offers useful information for ballet specialists and applied research studies aimed at ballet pedagogy. (Contains 2 tables and 5 figures.)

  2. Science leaders discuss budget crunch

    NASA Astrophysics Data System (ADS)

    Although funding for research fared relatively well in the budget proposed by the Reagan Administration for fiscal year (FY) 1987, leaders of the science community should expect lean times ahead for federal funding and should plan accordingly. This was the message delivered February 26-27, 1986, to nearly 400 participants in a conference at the National Academy of Sciences (NAS) in Washington, D.C.Leaders and policymakers from all segments of the research establishment were invited to attend the 2-day conference, which was sponsored by the Government-University-Industry Research Roundtable, an independent group associated with NAS, the National Academy of Engineering, and the Institute of Medicine. Discussions at the conference revolved around the question “What research strategies best serve the national interest in a period of budgetary stress?” After hearing perspectives from representatives from the Administration, industry, federal agencies, universities, and a federal laboratory, participants were divided into seven working groups. Each group was assigned a topic of discussion, such as “Management at the Campus Level,” “The Relative Roles of Federal Laboratories and Outside Research Institutions,” and “Possible Non-Federal Sources of Support: States, Industry, and Foundations.” On the second day of the conference, the working group chairmen reported back to the conference at large.

  3. Eisosomes promote the ability of Sur7 to regulate plasma membrane organization in Candida albicans

    PubMed Central

    Wang, Hong X.; Douglas, Lois M.; Veselá, Petra; Rachel, Reinhard; Malinsky, Jan; Konopka, James B.

    2016-01-01

    The plasma membrane of the fungal pathogen Candida albicans forms a protective barrier that also mediates many processes needed for virulence, including cell wall synthesis, invasive hyphal morphogenesis, and nutrient uptake. Because compartmentalization of the plasma membrane is believed to coordinate these diverse activities, we examined plasma membrane microdomains termed eisosomes or membrane compartment of Can1 (MCC), which correspond to ∼200-nm-long furrows in the plasma membrane. A pil1∆ lsp1∆ mutant failed to form eisosomes and displayed strong defects in plasma membrane organization and morphogenesis, including extensive cell wall invaginations. Mutation of eisosome proteins Slm2, Pkh2, and Pkh3 did not cause similar cell wall defects, although pkh2∆ cells formed chains of furrows and pkh3∆ cells formed wider furrows, identifying novel roles for the Pkh protein kinases in regulating furrows. In contrast, the sur7∆ mutant formed cell wall invaginations similar to those for the pil1∆ lsp1∆ mutant even though it could form eisosomes and furrows. A PH-domain probe revealed that the regulatory lipid phosphatidylinositol 4,5-bisphosphate was enriched at sites of cell wall invaginations in both the sur7∆ and pil1∆ lsp1∆ cells, indicating that this contributes to the defects. The sur7∆ and pil1∆ lsp1∆ mutants displayed differential susceptibility to various types of stress, indicating that they affect overlapping but distinct functions. In support of this, many mutant phenotypes of the pil1∆ lsp1∆ cells were rescued by overexpressing SUR7. These results demonstrate that C. albicans eisosomes promote the ability of Sur7 to regulate plasma membrane organization. PMID:27009204

  4. Que nous apprennent les petits frères et sœurs sur les signes précoces d’autisme?1

    PubMed Central

    Rogers, Sally J.

    2010-01-01

    L’objectif de cette revue est de présenter une synthèse des réponses que l’on peut actuellement apporter à la question de savoir quelles sont les premières caractéristiques comportementales qui prédisent le développement de l’autisme. L’article se centre sur 5 points : la présence de Troubles du Spectre Autistique (TSA) dans des groupes de frères et sœurs puînés d’enfants déjà diagnostiqués, les patterns et caractéristiques du développement moteur, les patterns et caractéristiques du développement social et émotionnel, les patterns et caractéristiques de la communication intentionnelle verbale et non verbale, et les patterns qui marquent le début de comportements pathognomoniques de TSA. La discussion porte sur les aspects inattendus des résultats et les pistes de recherche nouvelles qu’ils peuvent engendrer. PMID:20890377

  5. To discuss illicit nuclear trafficking

    SciTech Connect

    Balatsky, Galya I; Severe, William R; Wallace, Richard K

    2010-01-01

    The Illicit nuclear trafficking panel was conducted at the 4th Annual INMM workshop on Reducing the Risk from Radioactive and Nuclear Materials on February 2-3, 2010 in Washington DC. While the workshop occurred prior to the Nuclear Security Summit, April 12-13 2010 in Washington DC, some of the summit issues were raised during the workshop. The Communique of the Washington Nuclear Security Summit stated that 'Nuclear terrorism is one of the most challenging threats to international security, and strong nuclear security measures are the most effective means to prevent terrorists, criminals, or other unauthorized actors from acquiring nuclear materials.' The Illicit Trafficking panel is one means to strengthen nuclear security and cooperation at bilateral, regional and multilateral levels. Such a panel promotes nuclear security culture through technology development, human resources development, education and training. It is a tool which stresses the importance of international cooperation and coordination of assistance to improve efforts to prevent and respond to incidents of illicit nuclear trafficking. Illicit trafficking panel included representatives from US government, an international organization (IAEA), private industry and a non-governmental organization to discuss illicit nuclear trafficking issues. The focus of discussions was on best practices and challenges for addressing illicit nuclear trafficking. Terrorism connection. Workshop discussions pointed out the identification of terrorist connections with several trafficking incidents. Several trafficking cases involved real buyers (as opposed to undercover law enforcement agents) and there have been reports identifying individuals associated with terrorist organizations as prospective plutonium buyers. Some specific groups have been identified that consistently search for materials to buy on the black market, but no criminal groups were identified that specialize in nuclear materials or isotope smuggling

  6. Discussion on selected symbiotic stars

    NASA Technical Reports Server (NTRS)

    Viotti, Roberto; Hack, Margherita

    1993-01-01

    Because of its large variety of aspects, the symbiotic phenomenon is not very suitable for a statistical treatment. It is also not clear whether symbiotic stars really represent a homogeneous group of astrophysical objects or a collection of objects of different natures but showing similar phenomena. However we are especially interested in the symbiotic phenomenon, i.e., in those physical processes occurring in the atmosphere of each individual object and in their time dependence. Such a research can be performed through the detailed analysis of individual objects. This study should be done for a time long enough to cover all the different phases of their activity, in all the spectral ranges. Since the typical time scale of the symbiotic phenomena is up to several years and decades, this represents a problem since, for instance, making astronomy outside the visual region is a quite new field of research. It was a fortunate case that a few symbiotic stars (Z And, AG Dra, CH Cyg, AX Per, and PU Vul) had undergone remarkable light variations (or 'outbursts') in recent years, which could have been followed in the space ultraviolet with IUE, and simultaneously in the optical and IR with ground-based telescopes. But, in general, the time coverage of most of the symbiotic objects is too short to have a complete picture of their behavior. In this regard, one should recall Mayall's remark about the light curve of Z And: 'Z Andromedae is another variable that shows it will require several hundred years of observations before a good analysis can be made of its variations'. This pessimistic remark should be considered as a note of caution for those involved in the interpretation of the observations. We shall discuss a number of individual symbiotic stars for which the amount of observational data is large enough to draw a rather complete picture of their general behavior and to make consistent models. We shall especially illustrate the necessary steps toward an empirical model

  7. Panel discussion on energy efficiency.

    PubMed

    Heap, Brian; Kasemo, Bengt

    2010-01-01

    The session on energy efficiency had no formal presentations and was organized as a panel discussion with four panelists. It was concluded that energy efficiency and saving measures on the short term is the most effective way to contribute to a sustainable energy system. Measures to improve and encourage energy efficiency should be implemented at all levels; municipal/local, national and super-national. Prices can be an effective instrument but need to be combined with systemic level measures. The transport sector was identified as the one with largest near future potential for increased energy efficiency. Agriculture and food is also an area with very large energy consumption and large potential for increased energy efficiency. The global population issue is yet another relevant, challenging and complex issue. It was noted that energy audits for end users in business and society increase awareness and insights into what they pay for, and they are likely to promote actions to save energy. Many measures are believed to suffer from Jevin's paradox, i.e., that more efficient use of energy just leads to more energy consumption somewhere else. Many examples were given, however, where this does not happen. Another point put forward was that measures to make the energy system more efficient do not only mean constraints and regulations but also create great opportunities for market actors and societies.

  8. Terry Quist Discusses Skylab Experiment

    NASA Technical Reports Server (NTRS)

    1972-01-01

    San Antonio, Texas high school student, Terry C. Quist (left), and Dr. Raymond Gause of the Marshall Space Flight Center (MSFC), discuss the student's experiment to be performed aboard the Skylab the following year. His experiment, 'Earth Orbital Neutron Analysis' required detectors such as the one he is examining in this photo. The detector was to be attached to a water tank in Skylab. Neutrons striking the detectors left traces that were brought out by a chemical etching process after the Skylab mission. Quist's experiment seeked to record neutron hits, count them, and determine their direction. This information was to help determine the source of neutrons in the solar system. Quist was among 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. The nationwide scientific competition was sponsored by the National Science Teachers Association and the National Aeronautics and Space Administration (NASA). The winning students, along with their parents and sponsor teachers, visited MSFC two months earlier where they met with scientists and engineers, participated in design reviews for their experiments, and toured MSFC facilities. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of additional equipment. The equipment for the experiments was manufactured at MSFC.

  9. A discussion of image sharpness

    NASA Technical Reports Server (NTRS)

    Anuta, P.

    1982-01-01

    The image sharpness problem is discussed in terms of a scene which is viewed by a sensor. The sensor has some sort of function which is a nonpoint observing function, and it's a function that gathers energy from some region around a point in the scene. That energy is integrated and is contributed to each point or each sample that is taken of the scene. The samples become the pixels, and the pixels are assembled together into the digital image. Each one has some blurr or some of what is called the point's spread function creating the value of information or data that is seen in each pixel. Then the sensor and electronic part of the system acts on that signal out of the sensor and perhaps adds more blurring, more loss of resolution to the system. Finally, sampling and quantization of the data produce their effects. The signal is sampled at some rate and the digital image is created from that. The sampling or digitizing process puts the continuous voltage into a number of discrete binary levels, and another error is introduced there.

  10. The Palaeodiet of the Pericue Indians of the Cape Region of Baja California Sur, Mexico.

    NASA Astrophysics Data System (ADS)

    Beer, N.; Gonzalez, S.; Huddart, D.; Rosales-Lopez, A.; Lamb, A.

    2008-05-01

    The archaeology of the Pericue Indians inhabiting the Cape region of Baja California has long been an area of interest. The dolichocranic traits exhibited by this population have lead to suggestions that these people were a relic population of an early coastal migration into North America. The antiquity of directly dated Pericue human remains only reaches 3,000 B.P. with occupation sites dating back to 9,000 B.P. The site of Babisuri cave in Isla Espiritu Santo may demonstrate a very early human presence in Baja California Sur between 36,000 to 45,000 B.P. although the exact nature of this evidence is unclear. Increasing tourist development within this region threatens many archaeological sites particularly coastal shell middens and rock shelters. Current rescue excavations are yielding important information regarding many aspects of the culture of the Pericue Indians. Geochemical evidence of diet {d13C and d15N} taken from Pericue bone samples, modern and archaeological animals and modern plants is helping us to understand the complicated subsistence strategies of this group. Initial results highlight a complicated and diverse diet including marine and terrestrial resources, most likely exploited seasonally. Similarities between the diet of the Pericue and other nearby coastal Indian groups are clear and will be discussed. Pericue Indian material culture, combined with the exploitation of marine mammals and the construction of enormous shell mounds display parallels with other central and North American groups. The exploitation of marine mammals and the associated stone tools display striking similarities to the Chumash people of the Channel Islands of Coastal Southern California. Some of these cultural similarities will be highlighted in this presentation. Current genetic work is attempting to discover the nature of the similarities between the Chumash and Pericue groups as some cultural elements of each group have parallels with the other. Initial genetic

  11. Influence des effets de température quasi-statiques du premier ordre sur les dispositifs à ondes de surface transverses sur sillons gravés

    NASA Astrophysics Data System (ADS)

    Ballandras, S.; Gavignet, E.; Bigler, E.

    1995-02-01

    The present study is devoted to the theoretical calculation of the first order quasi-static temperature coefficient of surface transverse waves which can propagate under shallow groove gratings. The model presented here associates an analytical description of non-perturbed surface transverse waves on an anisotropic substrate developed by Auld and Tiersten's perturbation method. This approach has been implemented in the case of quartz delay lines corrugated with rectangular grooves. It is shown that singly rotated quartz cuts can be theoretically found exhibiting a first-order temperature coefficient close to zero. The sensitivity of this coefficient versus the groove depth is also theoretically demonstrated. La présente étude consiste à calculer le coefficient de température du premier ordre d'un résonateur à ondes transverses de surface se propageant sous un réseau de sillons gravés de forme quelconque. Ce calcul fait intervenir un modèle analytique de propagation des ondes sur un substrat anisotrope développé par Auld et une méthode de perturbation mise au point par Tiersten. Cette approche théorique a été mise en oeuvre pour traiter le cas des dispositifs à sillons gravés de profil rectangulaire sur quartz. On montre ainsi qu'il existe des coupes de quartz à simple rotation présentant un coefficient de température du premier ordre théorique proche de zéro. L'influence de la profondeur de gravure des sillons sur ce coefficient est également mise en évidence théoriquement.

  12. Évolution des lignes directrices sur le traitement de la dyslipidémie

    PubMed Central

    John Bosomworth, N.

    2014-01-01

    Résumé Objectif Comprendre comment les nouvelles lignes directrices sur la prise en charge du risque cardiovasculaire publiées par l’American Heart Association et l’American College of Cardiology (AHA-ACC) peuvent être interprétées et utilisées dans le contexte canadien. Sources des données Les lignes directrices de l’AHA-ACC ont été examinées, de même que toutes les références. Des recherches indépendantes dans PubMed ont été effectuées pour inclure l’ajout aux statines d’autres antihyperlipidémiants et l’emploi de calculatrices médicales visant à aider le patient à comprendre. Message principal Les nouvelles lignes directrices de l’AHA-ACC s’appuient sur les meilleures données probantes disponibles actuellement en matière de traitement de la dyslipidémie. Cela inclut le risque cardiovasculaire (CV) sur 10 ans comme seuil thérapeutique au lieu du taux de cholestérol des lipoprotéines de faible densité, de même que l’abandon des cibles thérapeutiques de lipoprotéines de faible densité. On met de plus en plus l’accent sur les interventions alimentaires et l’exercice, avec l’amorce d’un effort pour quantifier l’effet de ces interventions. Les statines constituent la principale intervention pharmacologique, et l’ajout d’autres médicaments pour accentuer la baisse lipidique n’est plus recommandé. En ce qui concerne l’application au Canada, les tables de risque de Framingham sont plus appropriées pour évaluer le risque que les équations de cohortes regroupées utilisées aux États-Unis. Les calculatrices du risque de maladie cardiovasculaire (MCV) devraient contenir de l’information sur l’âge cardiovasculaire et devraient pouvoir illustrer le risque et les interventions de rechange afin d’aider le patient à comprendre et de favoriser la prise de décision éclairée. Conclusion L’attention sur les meilleures données probantes concernant le risque CV peut simplifier le traitement de la

  13. MIS3 to late Holocene Palaeo-ice Thickness Constraints of Glacier Viedma, Hielo Patagonico Sur, Southern South America

    NASA Astrophysics Data System (ADS)

    Geiger, A.; Fabel, D.; Glasser, N. F.

    2014-12-01

    Southern South America is the only landmass intersecting the southern westerly winds (SWW), which critically shape southern hemispheric and global climate. At present palaeo-climatic datasets stretching the 3000 km of SWW influence are in latitudinal disagreement, suggesting a complex picture of SWW palaeo-behavior. In order to unravel the nature of the SWW over the last glacial cycle, a tighter grid of sensitive palaeo-proxies in the region is required. The work presented here is based on the palaeo-glaciology of the Viedma outlet (49°S, 72°W), the second largest glacier draining the Hielo Patagonico Sur (HPS). This locality corresponds to the present day center of the precipitation bearing SWW in southern South America, which are a key factor in maintaining the HPS. Any variation in SWW strength or location has a direct impact on glacial expansion in the region, hence palaeo-glacial geometries can provide key insights into SWW dynamics. Palaeo-ice surface, thickness and thinning rates spanning MIS3 to the late Holocene are presented based on 16 Be-10 exposure ages along three vertical transects covering the accumulation and ablation areas of glacier Viedma. Results indicate a maximum ice thickness over MIS3, a thickening over the Antarctic Cold Reversal (ACR), which overprinted the vertical expression of the LGM, and progressive ice surface lowering from the middle to the late Holocene. The palaeo-climatic implications will be discussed, particularly with focus on SWW positioning and behavior.

  14. [SENTIERI Project: discussion and conclusions].

    PubMed

    Pirastu, Roberta; Ricci, Paolo; Comba, Pietro; Bianchi, Fabrizio; Biggeri, Annibale; Conti, Susanna; Fazzo, Lucia; Forastiere, Francesco; Iavarone, Ivano; Martuzzi, Marco; Musmeci, Loredana; Pasetto, Roberto; Zona, Amerigo; Crocetti, Emanuele

    2014-01-01

    showing the increase, considering latency and the length of the observation period. Of further interest are results relating to diseases of the urinary tract such as kidney failure in the NPCSs of Basso bacino del fiume Chienti, Taranto, Milazzo and Priolo. Overall, the results discussed above are consistent with the previous findings pertaining to mortality for 1995-2002. The present analysis also introduces a new element - the study of cancer incidence and hospital discharges - which can tell us a great deal about diseases with high survival rates or non lethal ones. The first is the case of thyroid cancer, which presents increases in both databases and for both genders in a number of NPCSs (Brescia-Caffaro, Laghi di Mantova, Milazzo, Sassuolo- Scandiano and Taranto). The study of cancer incidence and hospital discharges also revealed cancer excesses for melanoma, breast cancer and non Hodgkin lymphoma in Brescia-Caffaro NPCS where PCBs (Polychlorinated biphenyl) are the site's main pollutant. PCBs, according to the 2013 evaluation of the International Agency for Research on Cancer, are ascertained human carcinogens for melanoma and probable carcinogens for breast cancer and non-Hodgkin lymphoma. The results pertaining to cancer incidence in the 17 NPCSs can also be presented using rankings by area or disease analyzed by a multivariate hierarchical Bayesian model. These rankings reveal an overlapping of credibility intervals, such that it is not possible to speak of a limited number of cancer sites or of certain NPCSs as being particularly affected. Every NPCS, therefore, must be considered individually and ordering them by ranking of cancer incidence wouldn't be appropriate. Data collected concerning some of the NPCSs in the context of the SENTIERI Project is so conclusive that remediation measures can immediately be put in place. This is the case in the Biancavilla and Brescia-Caffaro NPCSs. A similar conclusion can be drawn for complex locations such as Taranto

  15. Réalisation de réseaux sur polymères par laser UV

    NASA Astrophysics Data System (ADS)

    Castex, M. C.; Fischer, A.; Simeonov, D.; Adès, D.; Siove, A.

    2003-06-01

    Nous présentons ici une méthode très simple de réalisation de réseaux d'amplitude de pas sub-micronique sur des films polymères à base de carbazote déposés sur des substrat de silice. Les réseaux sont fabriqués en irradiant avec un faisceau laser à 193nm un masque de phase placé au contact du film. La qualité des réseaux obtenus permet désormais d'envisager la réalisation de micro-cavités lasers de type planaire permettant de sélectionner une émission laser monomode autour de 400nm.

  16. A new species of Rhadinella (Serpentes: Colubridae) from the Sierra Madre del Sur of Guerrero, Mexico.

    PubMed

    Campillo, Gustavo; Dávila-Galavíz, Luis Fernando; Flores-Villela, Oscar; Campbell, Jonathan A

    2016-04-12

    We describe a new species of Rhadinella from the Sierra Madre del Sur of Guerrero, Mexico, a region where the genus was previously unknown. This diminutive species is a member of a group of snakes previously allocated in the Rhadinaea godmani group, and more recently transferred to the genus Rhadinella. These snakes may have conspicuous dark longitudinal striping on a pale brown to orange background or may have dark brown to blackish dorsal ground coloration, which mostly or completely obfuscates a pattern of longitudinal striping. The new species is mostly dark with barely discernible slightly paler or darker striping (depending on how striping is interpreted). The closest relative of the new species, on the basis of morphological similarities and biogeography, appears to be Rhadinella donaji which occurs to the east in the Sierra Madre del Sur of Oaxaca about 275 km from the type-locality of the new species.

  17. Multimodal 3-D reconstruction of human anatomical structures using SurLens Visualization System.

    PubMed

    Adeshina, A M; Hashim, R; Khalid, N E A; Abidin, S Z Z

    2013-03-01

    In the medical diagnosis and treatment planning, radiologists and surgeons rely heavily on the slices produced by medical imaging devices. Unfortunately, these image scanners could only present the 3-D human anatomical structure in 2-D. Traditionally, this requires medical professional concerned to study and analyze the 2-D images based on their expert experience. This is tedious, time consuming and prone to error; expecially when certain features are occluding the desired region of interest. Reconstruction procedures was earlier proposed to handle such situation. However, 3-D reconstruction system requires high performance computation and longer processing time. Integrating efficient reconstruction system into clinical procedures involves high resulting cost. Previously, brain's blood vessels reconstruction with MRA was achieved using SurLens Visualization System. However, adapting such system to other image modalities, applicable to the entire human anatomical structures, would be a meaningful contribution towards achieving a resourceful system for medical diagnosis and disease therapy. This paper attempts to adapt SurLens to possible visualisation of abnormalities in human anatomical structures using CT and MR images. The study was evaluated with brain MR images from the department of Surgery, University of North Carolina, United States and CT abdominal pelvic, from the Swedish National Infrastructure for Computing. The MR images contain around 109 datasets each of T1-FLASH, T2-Weighted, DTI and T1-MPRAGE. Significantly, visualization of human anatomical structure was achieved without prior segmentation. SurLens was adapted to visualize and display abnormalities, such as an indication of walderstrom's macroglobulinemia, stroke and penetrating brain injury in the human brain using Magentic Resonance (MR) images. Moreover, possible abnormalities in abdominal pelvic was also visualized using Computed Tomography (CT) slices. The study shows SurLens' functionality as

  18. [Polyplacophoran communities (Mollusca: Polyplacophora) at Bahia de La Paz, Baja California Sur, México].

    PubMed

    García Ríos, Cedar I; Alvarez Ruiz, Migdalia

    2007-03-01

    Eight species of polyplacophorans have been reported from La Bahia de la Paz, Baja California Sur, Mexico. We add Lepidochitona beanii, Chaetopleura lurida, Stenoplax limaciformis, S. mariposa, Lepidozona clathrata, L. serrata and Acanthochitona arragonites, increasing the known number of species to 15. Ordination analysis of five chiton communities at the site suggests a correlation of wave exposure to species composition and diversity: communities with intermediate wave exposure have more species (richness) and higher diversity (Shannon's index).

  19. [Polyplacophoran communities (Mollusca: Polyplacophora) at Bahia de La Paz, Baja California Sur, México].

    PubMed

    García Ríos, Cedar I; Alvarez Ruiz, Migdalia

    2007-03-01

    Eight species of polyplacophorans have been reported from La Bahia de la Paz, Baja California Sur, Mexico. We add Lepidochitona beanii, Chaetopleura lurida, Stenoplax limaciformis, S. mariposa, Lepidozona clathrata, L. serrata and Acanthochitona arragonites, increasing the known number of species to 15. Ordination analysis of five chiton communities at the site suggests a correlation of wave exposure to species composition and diversity: communities with intermediate wave exposure have more species (richness) and higher diversity (Shannon's index). PMID:18457125

  20. Etude du stockage de l'hydrogene sur des nanostructures de carbone microporeuses

    NASA Astrophysics Data System (ADS)

    Poirier, Eric

    2007-12-01

    Le stockage de l'hydrogene par adsorption sur des adsorbants nano-structures a ete etudie sous differentes conditions de pression et de temperature. Les adsorbants etudies sont principalement des nanotubes de carbone a simple paroi ainsi que des structures metallo-organiques. Les mesures ont ete realisees a l'aide de systemes gravimetriques et volumetriques tres sensibles specialement mis au point pour de petits echantillons necessitant un degazage in situ. Les appareils developpes, au nombre de quatre, comprennent deux systemes gravimetriques et deux systemes volumetriques. Ensemble, ces systemes couvrent la plage de pressions (0-100) bars ainsi que la plage de temperatures (77-295) K. Les differentes analyses montrent que l'adsorption d'hydrogene sur les adsorbants nano-structures etudies est maximale a 77 K et varie entre environ (1.5 et 4) % masse. A temperature ambiante, l'adsorption croit lineairement avec la pression et demeure sous les 1% masse pour des pressions inferieures a 100 bars. L'adsorption d'hydrogene sur ces materiaux dans ces conditions se compare notamment a celle obtenue sur des charbons actives. La modelisation de l'adsorption a egalement ete realisee dans des conditions cryogeniques a l'aide du modele de Dubinin-Astakhov sous une forme adaptee pour l'adsorption supercritique. Les enthalpies d'adsorption calculees a partir de ce modele varient sous les 6 kJ/mole et sont donc consistantes avec des processus de physisorption. L'applicabilite du modele de Dubinin-Astakhov suggere que l'adsorption d'hydrogene puisse etre representee par un processus de remplissage des pores par un pseudo-liquide. Ces travaux s'inscrivent dans un contexte ou la capacite d'adsorption reelle des nanostructures de carbone est sujette a la controverse. En consequence, l'approche experimentale adoptee se distingue par les differentes demarches mises de l'avant pour l'obtention de mesures fiables sur des echantillons de faibles masses ainsi que par son caractere

  1. Mechanisms of anticonvulsant and sedative actions of the ethanolic stem-bark extract of Ficus sur Forssk (Moraceae) in rodents.

    PubMed

    Ishola, Ismail O; Olayemi, Sunday O; Yemitan, Omoniyi K; Ekpemandudiri, Ngozi K

    2013-11-01

    Ficus sur Forssk (Moraceae) is used in traditional African medicine in the treatment of epilepsy, pain and inflammations. Anticonvulsant activity was investigated using picrotoxin (PTX), strychnine (SCN), isoniazid (INZ), pentylenetetrazole (PTZ) and N-methyl-D-aspartic acid NMDA models of convulsion. The phytochemical analysis of the extract revealed the presence of flavonoids, saponins, tannins, alkaloids and anthraquinone. Oral administration of Ficus sur, 1 h before intraperitoneal injection of chemical convulsants significantly (p < 0.05) delayed the onset and prolonged the duration of convulsions in PTX, SCN, INZ, PTZ and NMDA-induced seizures. However, the anticonvulsant activity of the ethanolic extract of Ficus sur was significantly reversed following intraperitoneal pre-treatment with flumazenil (GABA receptor antagonist), cyproheptadine (5-HT2 receptor antagonist) and L-NNA (nitric oxide synthase inhibitor) in picrotoxin-induced convulsion. The data obtained suggest that ethanol extract of Ficus sur possessed significant anticonvulsant effect, thereby confirming the traditional uses of Ficus sur in the treatment of epilepsies; mechanisms of which could involve interaction with GABAergic, glycinergic, serotonergic and glutaminergic system barks.

  2. Phenylephrine preconditioning in embryonic heart H9c2 cells is mediated by up-regulation of SUR2B/Kir6.2: A first evidence for functional role of SUR2B in sarcolemmal KATP channels and cardioprotection.

    PubMed

    Jovanović, Sofija; Ballantyne, Thomas; Du, Qingyou; Blagojević, Miloš; Jovanović, Aleksandar

    2016-01-01

    ATP-sensitive K(+) (KATP) channels were originally described in cardiomyocytes, where physiological levels of intracellular ATP keep them in a closed state. Structurally, these channels are composed of pore-forming inward rectifier, Kir6.1 or Kir6.2, and a regulatory, ATP-binding subunit, SUR1, SUR2A or SUR2B. SUR1 and Kir6.2 form pancreatic type of KATP channels, SUR2A and Kir6.2 form cardiac type of KATP channels, SUR2B and Kir6.1 form vascular smooth muscle type of KATP channels. The presence of SUR2B has been described in cardiomyocytes, but its functional significance and role has remained unknown. Pretreatment with phenylephrine (100nM) for 24h increased mRNA levels of SUR2B and Kir6.2, without affecting those levels of SUR1, SUR2A and Kir6.1 in embryonic heart H9c2 cells. Such increase was associated with increased K(+) current through KATP channels and Kir6.2/SUR2B protein complexes as revealed by whole cell patch clamp electrophysiology and immunoprecipitation/Western blotting respectively. Pretreatment with phenylephrine (100nM) generated a cellular phenotype that acquired resistance to chemical hypoxia induced by 2,4-dinitrophenol (DNP; 10mM), which was accompanied by increased in K(+) current in response to DNP (10mM). Cytoprotection afforded by phenylephrine (100nM) was abolished by infection of H9c2 cells with adenovirus containing Kir6.2AFA, a mutant form of Kir6.2 with largely reduced K(+) conductance. Taking all together, the present findings demonstrate that the activation of α1-adrenoceptors up-regulates SUR2B/Kir6.2 to confer cardioprotection. This is the first account of possible physiological role of SUR2B in cardiomyocytes.

  3. Etude sur les tendons en materiaux composites et leur application aux ancrages postcontraints

    NASA Astrophysics Data System (ADS)

    Chennouf, Adil

    L'objectif general de la presente these est d'evaluer le comportement a l'arrachement et au fluage d'ancrages injectes constitues de tendons en materiaux composites afin d'etablir des recommandations plus appropriees et realistes pour le dimensionnement et la conception. Quatre types de tendons en materiaux composites, deux a base de fibres d'aramide et deux a base de fibres de carbone, ont ete utilises dans l'etude. Les travaux de recherche de cette these ont porte notamment sur: (I) Une caracterisation physique et mecanique des tendons en materiaux composites utilises dans l'etude. (II) Une etude en laboratoire sur les coulis de scellement. La premiere etape de cette etude a concerne le developpement d'un coulis de scellement performant adapte aux tendons en materiaux composites et a differentes situations d'injection. La seconde etape a traite des essais de caracterisations physique et mecanique du coulis de scellement developpe comparativement a trois coulis de scellement usuels d'un meme rapport E/L de 0,4. (III) Une etude sur des modeles reduits d'ancrages injectes. (IV) Une etude sur des modeles d'ancrages a grande echelle. La synthese de ces etudes a permis d'enoncer les principales conclusions suivantes: (1) Les valeurs moyennes des charges de rupture des tendons en materiaux composites ont ete de 1% a 29% superieures a celles specifiees par les manufacturiers. (2) L'etude sur les coulis de scellement a permis le developpement de coulis de ciment repondant aux criteres fixes, soient une grande stabilite, une bonne fluidite, une legere expansion et de bonnes caracteristiques mecaniques. (3) Les tendons en materiaux composites ont montre des contraintes d'adherence maximum superieures a celles des tendons en acier. (4) Le type de fibre, la configuration et le fini de surface des tendons en materiaux composites gouvernent leur resistance a l'adherence. (5) L'introduction de sable et d'autres ajouts comme les fines de silice et la poudre d'aluminium au coulis

  4. SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil

    PubMed Central

    Shindo, Takashi; Yamada, Mitsuhiko; Isomoto, Shojiro; Horio, Yoshiyuki; Kurachi, Yoshihisa

    1998-01-01

    The classical ATP sensitive K+ (KATP) channels are composed of a sulphonylurea receptor (SUR) and an inward rectifying K+ channel subunit (BIR/Kir6.2). They are the targets of vasorelaxant agents called K+ channel openers, such as pinacidil and nicorandil.In order to examine the tissue selectivity of pinacidil and nicorandil, in vitro, we compared the effects of these agents on cardiac type (SUR2A/Kir6.2) and vascular smooth muscle type (SUR2B/Kir6.2) of the KATP channels heterologously expressed in HEK293T cells, a human embryonic kidney cell line, by using the patch-clamp method.In the cell-attached recordings (145 mM K+ in the pipette), pinacidil and nicorandil activated a weakly inwardly-rectifying, glibenclamide-sensitive 80 pS K+ channel in both the transfected cells.In the whole-cell configuration, pinacidil showed a similar potency in activating the SUR2B/Kir6.2 and SUR2A/Kir6.2 channels (EC50 of ∼2 and ∼10 μM, respectively). On the other hand, nicorandil activated the SUR2B/Kir6.2 channel >100 times more potently than the SUR2A/Kir6.2 (EC50 of ∼10 μM and >500 μM, respectively).Thus, nicorandil, but not pinacidil, preferentially activates the KATP channels containing SUR2B. Because SUR2A and SUR2B are diverse only in 42 amino acids at their C-terminal ends, it is strongly suggested that this short part of SUR2B may play a critical role in the action of nicorandil on the vascular type classical KATP channel. PMID:9692785

  5. Intragenic single nucleotide polymorphism haplotype analysis of SUR1 mutations in familial hyperinsulinism.

    PubMed

    Glaser, B; Furth, J; Stanley, C A; Baker, L; Thornton, P S; Landau, H; Permutt, M A

    1999-01-01

    Familial hyperinsulinism (HI; MIM# 256450) is an autosomal recessive disorder of pancreatic beta-cell function, characterized by inadequate suppression of insulin secretion despite severe recurrent fasting hypoglycemia. Subtotal pancreatectomy is frequently required to prevent permanent neurologic sequelae. The incidence of HI in the Caucasian population is estimated at 1:50,000, however an apparent increased incidence among Ashkenazi Jews and Saudi Arabian Arabs has been reported. A locus for HI was assigned by linkage analyses to human chromosome 11p15.1. The sulfonylurea receptor (MIM# 600509, SUR1) and the potassium channel, inwardly rectifying, subfamily J member 11 (MIM# 600937, KIR6.2) genes, 2 components of the beta-cell K(ATP) channel, are clustered in this chromosomal region, and mutations in these genes have been implicated in HI. We previously demonstrated that two mutations in the SUR1 gene are present on approximately 88% of HI-associated chromosomes in Ashkenazi Jewish patients. Haplotype analysis with microsatellite markers flanking the gene revealed that one mutation (delF1388), reported only in Ashkenazi probands, occurred on two related extended haplotypes. By contrast, the second, more common mutation (3992-9g-->a) was associated with nine different intergenic haplotypes and has been reported in non-Jewish HI patients as well. In this study, we evaluated disease-associated chromosomes from 41 Ashkenazi Jewish and 2 non-Jewish HI patients carrying the 3992-9g-->a mutation by assessing haplotypes defined by nine common single nucleotide polymorphisms (SNPs), six in the SUR1 gene, and three in the KIR6.2 gene. Our results indicate that all 54 chromosomes carrying the 3992-9g-->a mutation in the Jewish patients appear to have originated from one founder mutation, whereas the same mutation on chromosomes from non-Jewish patients originated independently. Furthermore, our findings have implications concerning the HI-associated chromosomes on which no

  6. Instrumentation pour la spectroscopie laser sur faisceau d'ions rapides

    NASA Astrophysics Data System (ADS)

    Bazin, Marc

    Devant l'emergence des technologies exploitant l'infiniment petit, la spectroscopie atomique et moleculaire devient de plus en plus incontournable pour comprendre precisement les mecanismes quantiques impliques dans l'interaction des molecules. C'est le cas notamment de la nanotechnologie, de la dynamique reactionnelle des gaz a effet de serre ou simplement de l'identification des molecules constituant certains objets de l'astrophysique. Bien qu'un travail considerable soit deja accompli pour comprendre la dissociation ou la formation des molecules simples, il reste a vaincre la complexite des mecanismes impliques lorsque les molecules possedent plus de trois noyaux. Parmi les rares techniques de spectroscopie a tres haute resolution (jusqu'a la structure hyperfine), la spectroscopie laser sur faisceaux d'ions rapides est une methode experimentale eprouvee depuis trois decennies environ. Cette methode spectroscopique fournit des resultats comptant parmi les meilleurs pour obtenir des constantes moleculaires precises et permettre la reduction du spectre moleculaire. Une particularite remarquable de notre instrument est la possibilite d'enregistrer le signal de fragmentation moleculaire par laser via les etats de predissociation de la molecule etudiee. Notre contribution a ete d'ameliorer et de moderniser l'equipement existant. Nous avons augmente la resolution spectrale de notre instrument. Nous avons atteint notre principal objectif, a savoir, la possibilite d'acquerir des spectres selon deux modes : par detection du signal synchronisee sur le faisceau laser module en frequence ou par detection du signal directement par comptage. Cette derniere methode est une premiere sur ce type d'instrument et son principal interet a ete d'obtenir une meilleure mesure de l'elargissement de raie. Nous sommes parvenus a mettre clairement en evidence l'elargissement de raie avec la puissance laser en utilisant la methode de detection par comptage direct. La fluorescence induite par

  7. Grossesse sur cicatrice de césarienne: à propos d'un cas et revue de la literature

    PubMed Central

    Lachiri, Boutaina; Zazi, Abdelgheni; Benkerroum, Zineb; Hafidi, Moulay Rachid; Kouach, Jaouad; Rahali, Driss Moussaoui; Dehayni, Mohamed

    2015-01-01

    La grossesse sur cicatrice de césarienne est une forme rare de grossesse ectopique qui engage le pronostic vital et fonctionnel utérin par hémorragie ou par rupture utérine précoce. Nous rapportons le cas d'une grossesse ectopique sur cicatrice de césarienne diagnostiquée à 11 semaines d'aménorrhée suite à une aspiration blanche pour grossesse arrêtée chez une patiente de 43 ans porteuse d'un utérus bi-cicatriciel. A travers cette observation ainsi qu'une revue de la littérature les auteurs vont essayer de mettre le point sur les méthodes diagnostiques et thérapeutiques de cette entité rare afin d'améliorer la prise en charge. PMID:26213603

  8. Video 7 of 14: Classroom Discussion

    NASA Video Gallery

    This video segment documents the follow-up discussion, in which students discuss the results of their test flights. The session demonstrates how the teacher uses the inquiry method to evaluate stud...

  9. Why Discuss Sexuality in Elementary School?

    ERIC Educational Resources Information Center

    Bickmore, Kathy

    It is important to discuss sexuality with elementary students. Elementary teachers can help children learn to share public space with people who are similar and different from themselves. This should include discussions of homosexual people. One reason to discuss sexuality in elementary schools is that it is already present in students' lives (via…

  10. USENET Discussion Groups in Political Science Courses.

    ERIC Educational Resources Information Center

    Bailey, Martha

    1995-01-01

    Considers the applications and limitations of supplementing political science instruction with USENET discussion groups. Maintains that the engaging and topical nature of the discussion groups can enhance traditional course materials. Notes, however, that USENET comments often are not indicative of the general public. Briefly discusses reference…

  11. Leading Discussions: Opening up the Conversation

    ERIC Educational Resources Information Center

    Henning, John E.

    2005-01-01

    Leading a productive discussion, one that both engages students and enhances their understanding, may be the most complex and challenging task in teaching. This article explores three approaches to increasing the productivity of discussions. They include framing discussions in a way that allows students easier access to the topic, making the kind…

  12. Enhancing Motivation and Engagement through Collaborative Discussion

    ERIC Educational Resources Information Center

    Wu, Xiaoying; Anderson, Richard C.; Nguyen-Jahiel, Kim; Miller, Brian

    2013-01-01

    Fourth- and fifth-grade students' motivation and engagement during classroom discussions were investigated in 2 studies. Study 1 examined students' moment-by-moment engagement during collaborative peer-managed small-group discussions in comparison to conventional teacher-managed whole-class discussions. Study 2 evaluated the long term effects of…

  13. Effet de la composition des materiaux composites sur la caracterisation et detection par ondes de Lamb

    NASA Astrophysics Data System (ADS)

    Ostiguy, Pierre-Claude

    Les matériaux composites sont de plus en plus utilisés en aéronautique. Leurs excellentes propriétés mécaniques et leur faible poids leur procurent un avantage certain par rapport aux matériaux métalliques. Ceux-ci étant soumis à diverses conditions de chargement et environnementales, ils sont suceptibles de subir plusieurs types d'endommagements, compromettant leur intégrité. Des méthodes fiables d'inspection sont donc nécessaires pour évaluer leur intégrité. Néanmoins, peu d'approches non destructives, embarquées et efficaces sont présentement utilisées. Ce travail de recherche se penche sur l'étude de l'effet de la composition des matériaux composites sur la détection et la caractérisation par ondes guidées. L'objectif du projet est de développer une approche de caractérisation mécanique embarquée permettant d'améliorer la performance d'une approche d'imagerie par antenne piézoélectriques sur des structures composite et métalliques. La contribution de ce projet est de proposer une approche embarquée de caractérisation mécanique par ultrasons qui ne requiert pas une mesure sur une multitude d'échantillons et qui est non destructive. Ce mémoire par articles est divisé en quatre parties, dont les parties deux A quatre présentant les articles publiés et soumis. La première partie présente l'état des connaissances dans la matière nécessaires à l'acomplissement de ce projet de maîtrise. Les principaux sujets traités portent sur les matériaux composites, propagation d'ondes, la modélisation des ondes guidées, la caractérisation par ondes guidées et la surveillance embarquée des structures. La deuxième partie présente une étude de l'effet des propriétés mécaniques sur la performance de l'algorithme d'imagerie Excitelet. L'étude est faite sur une structure isotrope. Les résultats ont démontré que l'algorithme est sensible à l'exactitude des propriétés mécaniques utilisées dans le modèle. Cette

  14. Les enjuex éthiques entourant la recherche en santé sur les enfants

    PubMed Central

    2008-01-01

    RÉSUMÉ La recherche en santé est un devoir moral parce qu’elle est la base des soins probants prodigués par tous les dispensateurs de soins. Des politiques et des règlements précis régissent la tenue des recherches sur des humains. Il faut procéder à une évaluation éthique d’un projet de recherche donné avant de pouvoir l’entreprendre. La recherche sur les enfants pose d’énormes défis en matière de consentement éclairé et d’assentiment, de vulnérabilité et de potentiel de conflit d’intérêts (CDI). Les chercheurs en santé pédiatrique devraient prôner la participation des enfants à la recherche, tout en se montrant attentifs à en limiter les risques.

  15. Adsorption de gaz sur les materiaux microporeux modelisation, thermodynamique et applications

    NASA Astrophysics Data System (ADS)

    Richard, Marc-Andre

    2009-12-01

    Nos travaux sur l'adsorption de gaz dans les materiaux microporeux s'inscrivent dans le cadre des recherches visant a augmenter l'efficacite du stockage de l'hydrogene a bord des vehicules. Notre objectif etait d'etudier la possibilite d'utiliser l'adsorption afin d'ameliorer l'efficacite de la liquefaction de l'hydrogene des systemes a petite echelle. Nous avons egalement evalue les performances d'un systeme de stockage cryogenique de l'hydrogene base sur la physisorption. Comme nous avons affaire a des plages de temperatures particulierement etendues et a de hautes pressions dans la region supercritique du gaz, nous avons du commencer par travailler sur la modelisation et la thermodynamique de l'adsorption. La representation de la quantite de gaz adsorbee en fonction de la temperature et de la pression par un modele semi-empirique est un outil utile pour determiner la masse de gaz adsorbee dans un systeme mais egalement pour calculer les effets thermiques lies a l'adsorption. Nous avons adapte le modele Dubinin-Astakhov (D-A) pour modeliser des isothermes d'adsorption d'hydrogene, d'azote et de methane sur du charbon actif a haute pression et sur une grande plage de temperatures supercritiques en considerant un volume d'adsorption invariant. Avec cinq parametres de regression (incluant le volume d'adsorption Va), le modele que nous avons developpe permet de tres bien representer des isothermes experimentales d'adsorption d'hydrogene (de 30 a 293 K, jusqu'a 6 MPa), d'azote (de 93 a 298 K, jusqu'a 6 MPa) et de methane (de 243 a 333 K, jusqu'a 9 MPa) sur le charbon actif. Nous avons calcule l'energie interne de la phase adsorbee a partir du modele en nous servant de la thermodynamique des solutions sans negliger le volume d'adsorption. Par la suite, nous avons presente les equations de conservation de la niasse et de l'energie pour un systeme d'adsorption et valide notre demarche en comparant des simulations et des tests d'adsorption et de desorption. En plus de l

  16. The optimization research of the multi-response problems based on the SUR.

    PubMed

    Su, Haitao; Yao, Hong Mei; Zeng, Hui

    2015-03-01

    In the optimization design of products and processes in the biological medicine, we need to consider multiple characteristics of quality simultaneously, namely multi-response problems, multi-response optimization design can improve the quality of the products effectively, and realize enormous economic benefits and so multi-response optimization design is showing a more and more important role in continuous quality improvement activities. But usually there is no specific set of input variables to make all the response variables be optimal, and the traditional multi-response surface method cannot solve the correlation problem between multi-responses and regression model problem effectively. Because we can make a better fitting model and solve the problem of the correlation between the response variables at the same time with SUR method, this thesis uses the SUR method to model the relationship between each response and control variables, and makes predictions; confirms the satisfaction function of each response and the overall satisfaction function; combines with practical problems of a company in biological medicine field named SX to conduct empirical research, this thesis confirms the optimal factor level combination with the overall satisfaction function in the end, thus solves the multi-response optimization problems.

  17. Volvulus du grêle sur paquet d’ascaris: à propos d’un cas

    PubMed Central

    Diouf, Cheikh; Kane, Ahmed; Ndoye, Ndeye Aby; Ndour, Oumar; Faye-Fall, Aimé Lakh; Fall, Mbaye; Alumeti, Désiré Munyali; Ngom, Gabriel

    2016-01-01

    Nous rapportons un cas exceptionnel de volvulus nécrosé de l'intestin grêle dû à des ascaris adultes chez un enfant de 7 ans. A l'admission, l'enfant présentait le tableau d'occlusion intestinale qui évoluait depuis deux jours avec altération de l'état général. La radiographie de l'abdomen sans préparation retrouvait des niveaux hydroaériques de type grêlique et un aspect tigré évoquant le diagnostic d'une occlusion intestinale haute sur masse abdominale. Après la réanimation, le traitement chirurgical consistait en une laparotomie qui avait retrouvé un volvulus nécrosé de l'iléon terminale contenant des ascaris adultes. Une résection du grêle sur environ un mètre emportant le segment nécrosé suivie d'une iléostomie était réalisée. L'évolution a été favorable, l'anastomose iléo-colique fut réalisée quatre semaines plus tard. Au recul de deux ans l'enfant est indemne de tout symptôme. PMID:27795803

  18. Visual Analysis and Dissemination of Scientific Literature Collections with SurVis.

    PubMed

    Beck, Fabian; Koch, Sebastian; Weiskopf, Daniel

    2016-01-01

    Bibliographic data such as collections of scientific articles and citation networks have been studied extensively in information visualization and visual analytics research. Powerful systems have been built to support various types of bibliographic analysis, but they require some training and cannot be used to disseminate the insights gained. In contrast, we focused on developing a more accessible visual analytics system, called SurVis, that is ready to disseminate a carefully surveyed literature collection. The authors of a survey may use our Web-based system to structure and analyze their literature database. Later, readers of the survey can obtain an overview, quickly retrieve specific publications, and reproduce or extend the original bibliographic analysis. Our system employs a set of selectors that enable users to filter and browse the literature collection as well as to control interactive visualizations. The versatile selector concept includes selectors for textual search, filtering by keywords and meta-information, selection and clustering of similar publications, and following citation links. Agreement to the selector is represented by word-sized sparkline visualizations seamlessly integrated into the user interface. Based on an analysis of the analytical reasoning process, we derived requirements for the system. We developed the system in a formative way involving other researchers writing literature surveys. A questionnaire study with 14 visual analytics experts confirms that SurVis meets the initially formulated requirements.

  19. Evaluation des connaissances des parents sur les bronchiolites aiguës

    PubMed Central

    Gueddari, Widad; Tazi, Abderrahmane; Ouardi, Amine; Nani, Samira; Zineddine, Abdelhadi

    2014-01-01

    Les infections respiratoires (IR) constituent la deuxième cause de mortalité infantile au Maroc, dû en partie à l'absence d'information et de sensibilisation. Le but de ce travail était d’évaluer les connaissances des parents sur la bronchiolite aiguë, infection respiratoire très fréquente. Nous avons réalisé une enquête basée sur un questionnaire, auprès de parents de nourrissons consultants pour toux, avec ou sans gêne respiratoire. 180 parents ont été inclus dans l’étude. Les parents pensaient que l'infection respiratoire était secondaire au climat froid (96%); seuls 4% ont évoqué une origine infectieuse. Aucun des parents ne savait que le lavage des mains était un moyen de prévention de la transmission. Les parents ont majoritairement répondu que la kinésithérapie respiratoire ne servait à rien (65%), et qu'elle était nocive (24.5%). Ce manque de connaissances fondamentales en matière d'IR et de bronchiolite en particulier, devrait inciter à entreprendre un programme de sensibilisation PMID:25328606

  20. Implementation of tsunami disaster prevention measures in the municipality of San Rafael del Sur, Nicaragua

    NASA Astrophysics Data System (ADS)

    Strauch, W.; Talavera, E.; Acosta, N.; Sanchez, M.; Mejia, E.

    2007-05-01

    The Nicaraguan Pacific coast presents considerable tsunami risk. On September 1, 1992, a tsunami caused enormous damage in the infrastructure and killed more than 170 people. A pilot project was conducted between 2006 and 2007 in the municipality of San Rafel del Sur, area of Masachapa, The project included multiple topics of tsunami prevention measures and considering the direct participation of the local population, as: -General education on disaster prevention, participative events; -Investigation of awareness level and information needs for different population groups; -Specific educational measures in the schools; -Publication of brochures, calendars, news paper articles, radio programs, TV spots -Development of local tsunami hazard maps, 1:5,000 scale; (based on previous regional tsunami hazard mapping projects and local participation) -Development of a tsunami warning plan; -Improvements of the national tsunami warning system. -Installation of sirens for tsunami warning -Installation of tsunami signs, indicating hazardous areas, evacuation routes, safe places; -Realization of evacuation drills in schools. Based on the experiences gained in Masachapa it is planned to run similar projects in other areas along the Nicaraguan Pacific coast. In the project participated the local municipality and local stakeholders of San Rafael del Sur, Ministry of Education, National Police, Nicaraguan Red Cross, Ministry of Health, Ministry of Tourism, Nicaraguan Geosciences Institute (INETER), National System for Disaster Prevention (SINAPRED), Swiss Agency for Development and Cooperation (SDC). It was financed by SDC and INETER.

  1. Cancer du sein sur tissu mammaire ectopique: à propos de 2 cas

    PubMed Central

    Haddad, Houssam; Bourhaleb, Zouhour; El Harroudi, Tijani; Mezouar, Loubna; El Hfid, Mohamed

    2012-01-01

    Le cancer du sein sur tissu mammaire ectopique est une tumeur rare qui représente 0,2 à 0,6% de l′ensemble des cancers du sein. Les auteurs en rapportent 2 cas pris en charge dans 2 centres d′oncologie marocains. Il s′agit de 2 patientes âgées de 31 ans et 47 ans présentant un cancer du sein sur tissu mammaire ectopique en situation axillaire. Une tumorectomie avec curage ganglionnaire axillaire homolatéral a été réalisée chez les 2 patientes dont une après une chimiothérapie néoadjuvante. Le traitement adjuvant a compris une chimiothérapie, radiothérapie puis une hormonothérapie. Après un recul de 12 mois et 20 mois respectivement, les 2 patientes sont en rémission complète. PMID:23330041

  2. A discussion of dynamic stability measurement techniques

    NASA Technical Reports Server (NTRS)

    Johnson, W.

    1975-01-01

    Techniques for the measurement of the dynamic stability of linear systems are discussed. Particular attention is given to an analysis of the errors in the procedures, and to methods for calculating the system damping from the data. The techniques discussed include: transient decay, moving block analysis, spectral analysis, random decrement signatures, transfer function analysis, and parameter identification methods. The special problems of rotorcraft dynamic stability testing are discussed.

  3. A discussion of bunched beam stochastic cooling

    SciTech Connect

    Neuffer, David; /Fermilab

    2005-08-01

    The analysis of Herr and Mohl[1] is used as a basis for a discussion of bunched beam cooling in the Fermilab recycler and the Tevatron. Differences between the two cooling regimes are discussed. Criteria discussed in that paper imply the failure of stochastic cooling in the Tevatron while permitting the success of stochastic cooling in the Recycler. These ''predictions'' are in agreement with observations.

  4. Prevalence of infection with Toxoplasma gondii in landrace and mixed breed pigs slaughtered in Baja California Sur state, Mexico

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Purpose We performed a cross-sectional study to determine the seroprevalence of Toxoplasma gondii infection in 308 domestic pigs slaughtered in La Paz, Baja California Sur State, Mexico using the modified agglutination test (MAT, cut off 1:25). Results Forty (13%) of the 308 pigs were seropositive ...

  5. Effets de la pollution de l’air sur la santé

    PubMed Central

    Abelsohn, Alan; Stieb, Dave M.

    2011-01-01

    Résumé Objectif Faire connaître aux médecins de famille les effets de la pollution atmosphérique sur la santé et indiquer quels conseils donner aux patients vulnérables pour qu’ils soient moins exposés. Sources de l’information On a consulté MEDLINE à l’aide des termes relatifs à la pollution atmosphérique et à ses effets indésirables. On a révisé les articles en anglais publiés entre janvier 2008 et décembre 2009. La plupart des études contenaient des preuves de niveau II. Principal message Au Canada, la pollution de l’air extérieur cause une morbidité et une mortalité importantes. Elle peut affecter le système respiratoire (exacerbation de l’asthme et de la maladie pulmonaire obstructive chronique) et le système cardiovasculaire (déclencher l’arythmie, l’insuffisance cardiaque et les AVC). La cote air santé (CAS) est un nouvel outil de communication mis au point par Santé Canada et Environnement Canada qui indique sur une échelle de 1 à 10, le risque pour la santé causé par la pollution atmosphérique. La CAS est largement diffusée dans les médias et cet outil pourrait être utile au médecin de famille pour inciter les patients à haut risque (comme ceux qui souffrent d’asthme, de maladie pulmonaire obstructive chronique ou d’insuffisance cardiaque) à réduire leur exposition à la pollution atmosphérique. Conclusion Le médecin de famille peut se servir de la CAS et de ses messages sur la santé pour enseigner aux asthmatiques et aux autres patients à risque élevé la façon de réduire les risques pour la santé causés par la pollution atmosphérique.

  6. Improving Classroom Discussion: A Rhetorical Approach

    ERIC Educational Resources Information Center

    Bruss, Kristine S.

    2009-01-01

    In this article, the author describes a project designed to take the dread out of discussion in a first-year interdisciplinary humanities course at Sewanee: The University of the South, a private liberal arts college in Tennessee. The Responsible Intellectual Discussion project, known as RID, was created in conjunction with the college's Eloquence…

  7. Affordances and Constraints of Electronic Discussions.

    ERIC Educational Resources Information Center

    Hunt, Russell A.

    The most common consequence of setting up an "electronic discussion group" for a university class or a group of faculty is a flurry of initial greetings followed by an enduring silence. Only a small proportion of computer users are active and sophisticated enough to read regularly and feel disposed to participate actively. Written discussion may…

  8. Global Leadership Competencies: A Review and Discussion

    ERIC Educational Resources Information Center

    Jokinen, Tiina

    2005-01-01

    Purpose: From the competency point of view, this article aims to review and discuss existing global leadership and other related literature, and to combine findings and suggestions provided in previous literature in a more integrative framework of global leadership competencies. Design/methodology/approach: The paper reviews and discusses the…

  9. Public Energy Education: Issues for Discussion. Draft.

    ERIC Educational Resources Information Center

    Public Energy Education Task Force.

    This paper was intended to stimulate discussion of energy education issues at a conference on energy issues. The discussion ranges through numerous topics at issue in energy education including public energy awareness, definition of public education, the distinction between public education and public relations, and the presentation of a model…

  10. Building Knowledge and Community through Online Discussion

    ERIC Educational Resources Information Center

    Skinner, Elisabeth

    2007-01-01

    A web conference "adds value by generating discussion among a diverse student group" (Skinner, 2004a, p. 12). Or does it? A significant concern is the extent to which learners construct knowledge and develop a learning community through online discussion. Critics argue that genuine knowledge construction is difficult to achieve. This study…

  11. 33 CFR 240.5 - Discussion.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CREDIT FOR FLOOD CONTROL § 240.5 Discussion. Discussion of this legislation is contained in the... flood control works for projects under study. Both general provisions would enable local interests to... of the Federal project for the purpose of benefit-to-cost analysis, as well as subsequent...

  12. Electronic Mail as an Academic Discussion Forum.

    ERIC Educational Resources Information Center

    Burton, Paul F.

    1994-01-01

    Describes the use of electronic mail to facilitate discussion of a range of related topics. Principal features of computer-mediated communication are reviewed, and a case study of a discussion that lasted two months is presented. The ethics of using material contained in electronic mail messages for further study and research is considered.…

  13. Discussion-Based Instruction in Drug Metabolism.

    ERIC Educational Resources Information Center

    Ruenitz, Peter C.

    1995-01-01

    A flexible strategy for large-group pharmacy instruction in drug metabolism has students prepare and discuss answers to fact-oriented study questions, addressing fundamentals covered in a textbook, with regular evaluation of in-class student responses to higher-order review questions. This discussion-based approach has brought sustained…

  14. Media Education--Discussion or Analysis?

    ERIC Educational Resources Information Center

    Ferguson, Bob

    1977-01-01

    Aspects of "liberalism" incorporating notions of balance, fairness, objectivity, and common sense are discussed in relation to the teaching of media studies. The British TV series "Looking at Television" is examined to clarify the way which the liberal ethos pervades the series to its detriment. Liberalism is shown as allowing discussion, but not…

  15. Managing the Paradoxes of Discussion Pedagogy

    ERIC Educational Resources Information Center

    Piro, Jody S.; Anderson, Gina

    2015-01-01

    Discussion pedagogy is part of a larger curricular goal that intersects the two aspirations of diversity of perspectives and democratic inquiry in that it challenges stereotypes and assumptions through student discourse. Yet, teaching with discussion is a complex and sometimes ambiguous endeavor that leaves instructors feeling pulled between…

  16. Learning Reading Strategies with Online Discussion

    ERIC Educational Resources Information Center

    Liu, I-Fang; Ko, Hwa-Wei; Wu, Sheng-Yi

    2014-01-01

    Teachers experience difficulty demonstrating prediction strategies and leading discussions in traditional classrooms. It is also unclear whether online discussion can contribute to reading comprehension. The purpose of this study is to create an online reading system to investigate whether learners can acquire reading strategies and enhance their…

  17. Threaded Discussion Instructional Strategies and Student Performance

    ERIC Educational Resources Information Center

    Krull, Rodger Pratt

    2013-01-01

    Educators need insight into what instructional strategies are effective in the online environment, but few researchers have contrasted threaded discussion strategies and measures of student performance using a quantitative approach. Also, the effectiveness of threaded discussion strategies across all student generation groups or between genders is…

  18. Building Fires: Raising Achievement through Class Discussion

    ERIC Educational Resources Information Center

    Kahn, Elizabeth

    2007-01-01

    According to a growing body of research, discussion-based instruction, in the context of high academic demands, significantly enhances student achievement in reading. The effects apply to below- as well as above-average-ability students. These findings confirm what secondary English teachers have believed all along about the value of discussion.…

  19. Discussion Forum for Technical Codes Users

    SciTech Connect

    Kaspar, Bryce P.; Dillon, Heather E.

    2006-03-30

    One goal of the Building Energy Codes Program (BECP) is to provide useful, easy to understand information about the national energy codes. A forum where users could ask for, and receive clarification on these codes and software from other users would allow the Energy codes project to reach and instruct a broader audience for a modest resource cost. The forum proposed would be a staff moderated discussion board where staff would post topics, and users would post discussion of those topics, with staff joining in to the discussions. The forum would be moderated by staff members, to remove objectionable and irrelevant postings, and to answer any technical questions that arise. The topics and discussions would be archived and searchable to allow users to answer their own questions, if they pertain to a previously discussed topic.

  20. Late Cardiac Events after Childhood Cancer: Methodological Aspects of the Pan-European Study PanCareSurFup

    PubMed Central

    Feijen, Elizabeth A. M.; Font-Gonzalez, Anna; van Dalen, Elvira C.; van der Pal, Helena J. H.; Reulen, Raoul C.; Winter, David L.; Kuehni, Claudia E.; Haupt, Riccardo; Alessi, Daniela; Byrne, Julianne; Bardi, Edit; Jakab, Zsuzsanna; Grabow, Desiree; Garwicz, Stanislaw; Jankovic, Momcilo; Levitt, Gill A.; Skinner, Roderick; Zadravec Zaletel, Lorna; Hjorth, Lars; Tissing, Wim J. E.; de Vathaire, Florent; Hawkins, Mike M.; Kremer, Leontien C. M.

    2016-01-01

    Background and Aim Childhood cancer survivors are at high risk of long-term adverse effects of cancer and its treatment, including cardiac events. The pan-European PanCareSurFup study determined the incidence and risk factors for cardiac events among childhood cancer survivors. The aim of this article is to describe the methodology of the cardiac cohort and nested case-control study within PanCareSurFup. Methods Eight data providers in Europe participating in PanCareSurFup identified and validated symptomatic cardiac events in their cohorts of childhood cancer survivors. Data on symptomatic heart failure, ischemia, pericarditis, valvular disease and arrhythmia were collected and graded according to the Criteria for Adverse Events. Detailed treatment data, data on potential confounders, lifestyle related risk factors and general health problems were collected. Results The PanCareSurFup cardiac cohort consisted of 59,915 5-year childhood cancer survivors with malignancies diagnosed between 1940 and 2009 and classified according to the International Classification of Childhood Cancer 3. Different strategies were used to identify cardiac events such as record linkage to population/ hospital or regional based databases, and patient- and general practitioner-based questionnaires. Conclusion The cardiac study of the European collaborative research project PanCareSurFup will provide the largest cohort of 5-year childhood cancer survivors with systematically ascertained and validated data on symptomatic cardiac events. The result of this study can provide information to minimize the burden of cardiac events in childhood cancer survivors by tailoring the follow-up of childhood cancer survivors at high risk of cardiac adverse events, transferring this knowledge into evidence-based clinical practice guidelines and providing a platform for future research studies in childhood cancer patients.  PMID:27643694

  1. Ophthalmic Combination of SurR9-C84A and Trichostatin-A Targeting Molecular Pathogenesis of Alkali Burn

    PubMed Central

    Roy, Kislay; Sriramoju, Bhasker; Kanwar, Rupinder K.; Kanwar, Jagat R.

    2016-01-01

    Background: Alkali burn is a frequently occurring ocular injury that resembles ocular inflammation caused by eye allergies, infection, and refractive surgeries. Methods: We investigated the synergistic regenerative potential of dominant negative survivin mutant (SurR9-C84A) and histone deacetylase (HDAC) inhibitor trichostatin-A (TSA) against alkali burn and corneal haze using human keratocytes and rabbit alkali burn model (Female New Zealand white rabbits). Results: Combination of SurR9-C84A and TSA suppressed levels of transforming growth factor (TGF)-β, alpha smooth-muscle actin (α-SMA), fibronectin and HDAC1, leading to apoptosis in myofibroblast cells and, showed the potential to clear the corneal haze. An insult with 0.5 N NaOH for 1 min led to neutrophils infiltration and formation of large vacuoles in the stroma. Treatments with TSA and SurR9-C84A for 40 min led to improvement in the conjunctival and corneal tissue integrity, marked by an increase in clathrin, and claudin expressions. An increase in TGF-β and endogenous survivin confirmed wound healing and cell proliferation in rabbit cornea. The blood analysis revealed a substantial decrease in the RBC, WBC, platelets, or the hemoglobin content post alkali burn. The cytokine array analysis revealed that NaOH induced expressions of IL-1α and MMP-9, which were found to be significantly downregulated (1.8 and 11.5 fold respectively) by the combinatorial treatment of SurR9-C84A and TSA. Conclusion: Our results confirmed that combination of SurR9-C84A with TSA worked in synergy to heal ocular injury and inflammations due to alkali burn and led to the regeneration of ocular tissue by increasing clathrin, claudin, survivin, and TGF-β and reversal of alkali burn by suppressing IL-1α and MMP-9 without inducing haze. PMID:27516741

  2. The Periplasmic Bacterial Molecular Chaperone SurA Adapts Its Structure to Bind Peptides in Different Conformations to Assert a Sequence Preference for Aromatic Residues

    SciTech Connect

    Xu, X.; Wang, S.; Hu, Y.-X.; McKay, D.B.

    2009-06-04

    The periplasmic molecular chaperone protein SurA facilitates correct folding and maturation of outer membrane proteins in Gram-negative bacteria. It preferentially binds peptides that have a high fraction of aromatic amino acids. Phage display selections, isothermal titration calorimetry and crystallographic structure determination have been used to elucidate the basis of the binding specificity. The peptide recognition is imparted by the first peptidyl-prolyl isomerase (PPIase) domain of SurA. Crystal structures of complexes between peptides of sequence WEYIPNV and NFTLKFWDIFRK with the first PPIase domain of the Escherichia coli SurA protein at 1.3 A resolution, and of a complex between the dodecapeptide and a SurA fragment lacking the second PPIase domain at 3.4 A resolution, have been solved. SurA binds as a monomer to the heptapeptide in an extended conformation. It binds as a dimer to the dodecapeptide in an alpha-helical conformation, predicated on a substantial structural rearrangement of the SurA protein. In both cases, side-chains of aromatic residues of the peptides contribute a large fraction of the binding interactions. SurA therefore asserts a recognition preference for aromatic amino acids in a variety of sequence configurations by adopting alternative tertiary and quaternary structures to bind peptides in different conformations.

  3. Metal concentrations in demersal fish species from Santa Maria Bay, Baja California Sur, Mexico (Pacific coast).

    PubMed

    Jonathan, M P; Aurioles-Gamboa, David; Villegas, Lorena Elizabeth Campos; Bohórquez-Herrera, Jimena; Hernández-Camacho, Claudia J; Sujitha, S B

    2015-10-15

    Concentrations of 11 trace metals (Fe, Mn, Cr, Cu, Ni, Co, Pb, Zn, Cd, As, Hg) in 40 fish species from Santa Maria Bay, Baja California Sur, Mexico, the strategically important area for marine mammals and organisms were analyzed. Based on their concentrations the ranking of metals Fe>Zn>Ni>Cr>Mn>Pb>Cu>Co>As>Cd>Hg suggests that organism size, metabolism and feeding habits are correlated with metal concentrations. Local geological formations affect the concentrations of different metals in the aquatic environment and are subsequently transferred to fishes. The correlation analysis suggests that metabolism and nurturing habits impact the concentration of metals. Concentrations of Fe and Mn appear to be influenced by scavenging and absorption processes, which vary by species. The considerable variability in the metal concentrations obtained in different species underscores the importance of regular monitoring.

  4. Complications of Poly Implant Prothèse breast implants: the current discussion.

    PubMed

    Kolios, Leila; Hirche, Christoph; Spiethoff, Alexander; Daigeler, Adrien; Lehnhardt, Marcus

    2013-03-01

    Against the background of the current discussion about Poly Implant Prothèse (PIP, Seyne-sur-mer, France) breast implants, we want to present a case demonstrating the complications such as implant rupture, silicone dissemination and level III silicone lymphadenopathy. A 29-year-old woman with cosmetic breast augmentation with PIP implants 5 years previously showed a sensitive swelling in her right axilla and neck region. All tests to detect an infectious or lymphomatous lymphadenopathy were negative. After ultrasound and MRI, rupture of the right implant was assumed and multiple pathologically enlarged lymph nodes up to supraclavicular region were shown. An excision biopsy of one axillary lymph node was performed; the histological examination detected a strong silicone lymphadenopathy. Surgical removal of both implants as well as capsulectomy was performed and 14 axillary lymph nodes up to level II were resected. Histologic evaluation confirmed the previous results. Our case underlines the actual discussion concerning increased rupture rate and massive silicone lymphadenopathy by PIP implants. The Agence Francaise de Sécurité Sanitaire des Produits de Santé (AFSSAPS) recommends clinical and ultrasound examination every 6 months for women with PIP implants. Any rupture, suspected rupture or leakage of prosthesis should lead to its explantation as well as that of the contralateral implant. In cases of unusual signs of inflammation, histological and immunohistochemical samples are to be taken. PMID:23480085

  5. Chinese women's participation in fertility discussions.

    PubMed

    Li, L

    1993-01-01

    In an attempt to better understand the process through which the family planning (FP) programs and socioeconomic developments in China affect fertility, women's participation in fertility discussions with their husbands are examined as an intermediate factor in a study based on results of a random survey of 6654 ever-married women of reproductive age from 7 cities and 30 counties of Guangdong. First, it must be noted that Chinese couples do have individual choices (albeit quite limited ones) about their fertility; they can choose to follow or ignore government policy or they can choose to remain childless. The present study has 3 major hypotheses: 1) the more a woman is involved in fertility discussions with her husband, the fewer children she will have; 2) urban women with a higher educational status will be more likely to have such discussions; and 3) women who are contacted individually by FP personnel are more likely to be involved in fertility discussions. After a discussion of data collection and variables (number of living children, education of wife and husband, age at marriage, residence, living with parents, contacted by FP personnel, and discussion with husband), the results are presented in terms of zero-order correlation coefficients indicating their relationships. The bivariate analysis supported the hypotheses. Multiple regression analysis showed that age at marriage, education of wives and husbands, FP contacts, and participation in discussions remain significant fertility determinants (but the correlation between fertility and residence becomes trivial). A further regression model indicated that a woman's educational attainment is the most significant positive indication of their participation in fertility discussions. These results imply that as women's status continues to improve in China and the deeply-rooted patriarchal tradition loses hold, increased gender equity and education will influence a fertility decline. FP personnel could also

  6. Recommandations sur l’examen pelvien de dépistage systématique

    PubMed Central

    Tonelli, Marcello; Gorber, Sarah Connor; Moore, Ainsley; Thombs, Brett D.

    2016-01-01

    Résumé Objectif Examiner les lignes directrices de 2014 de l’American College of Physicians (ACP) en matière d’examens pelviens de dépistage du cancer (autre que du col), des maladies inflammatoires pelviennes ou d’autres affections gynécologiques bénignes afin de déterminer si les lignes directrices de l’ACP en matière d’examens pelviens systématiques sont conformes aux normes établies par le Groupe d’étude canadien sur les soins de santé préventifs (GECSSP) et peuvent être adaptées ou adoptées. Méthodologie La méthode SNAP-IT (Smooth National Adaptation and Presentation of Guidelines to Improve Thrombosis Treatment) a servi à déterminer si les lignes directrices de l’ACP étaient conformes aux normes du GECSSP et pouvaient être adaptées ou adoptées. Recommandations Le GECSSP recommande de ne pas effectuer un examen pelvien de dépistage des cancers non cervicaux, des maladies inflammatoires pelviennes ou d’autres affections gynécologiques chez les femmes asymptomatiques. Il s’agit d’une forte recommandation reposant sur des données probantes de qualité modérée. Conclusion Le GECSSP adopte la recommandation en matière d’examen pelvien de dépistage, comme publiée par l’ACP en 2014.

  7. Segundo Catálogo Estelar del Hemisferio Sur con Astrolabio Fotoeléctrico PAII

    NASA Astrophysics Data System (ADS)

    Manrique, W. T.; Podestá, R. C.; Alonso, E.; Actis, E. V.; Pacheco, A. M.; Bustos, G.; Lizhi, L.; Zezhi, W.; Fanmiao, Z.; Hongqi, W.; Perdomo, R.

    Recordamos que entre el Observatorio Astronómico ``Félix Aguilar'', el Observatorio Astronómico de Beijing y el Observatorio Astronómico de La Plata, se ha convenido en desarrollar un Proyecto de Investigación conjunto, para la observación sistemática de estrellas en el Hemisferio Sur, con el objeto de la elaboración de un Catálogo Estelar Global utilizando un Astrolabio Fotoeléctrico PAII del Observatorio de Beijing, que ha sido usado con éxito en la República de China. En este trabajo se presenta el Segundo Catálogo Estelar del Hemisferio Sur, derivado de las observaciones realizadas con el PAII instalado en el OAFA, durante el períiodo Febrero de 1992 a Marzo de 1997. En este lapso se han observado mas de 400000 pasajes estelares, obteniéndose las correcciones Δ α y Δ δ de 5241 estrellas del FK4, FK5, FK5 Ext., SRS, CAMC y GC. Las precisiones medias son del orden de ± 3,2 ms en ascensión recta y ±0."057 en declinación. Rango de magnitudes : 2,0 a 11,5 Rango de declinaciones : -3o a -60o Epoca Media : 1994.9 Se analizan los residuos en función de la magnitud y tipo espectral, correcciones de grupo y frecuencia de distribución Δ α y Δ δ.

  8. Modern carbonate sediments and environments of the LaPaz region, Baja California Sur, Mexico

    SciTech Connect

    Halfar, J.; Ingle, J.C. Jr.; Cruz-Orozco, R.; Godinez-Orta, L.

    1996-12-31

    The Gulf of California represents one of the most productive and unique marginal seas in the world. The mouth of the Gulf captures warm equatorial water while annual wind patterns assure major upwelling of nutrient-rich water leading to a rich marine biota. These conditions have created a wide array of tropical through warm temperate carbonate environments. The most unusual of these environments is located in the La Paz region of Baja California Sur where tropical-subtropical water temperatures and low rainfall have allowed growth of corals, calcareous red algae, and other shelled invertebrates to form a carbonate bank environment. Sampling and mapping transacts in shallow bays north of La Paz and on the adjacent Espiritu Santo island have revealed a full spectrum of subenvironments including mangrove bordered, terrigenous mud dominated coastal zones, which grade into carbonate tidal flats. In addition, single coral heads as well as incipient reef structures constructed by Porites and Pocillopora coral are present in deeper water areas. Coralline red algae, which are increasingly utilized for paleoenvironmental reconstructions, grow in high abundance on coral debris and in soft sediments and turn out to be main contributors to the La Paz carbonates. Analysis of siliciclastic admixtures, grain size and organic carbon content allow a classification of distinct environments. These data are supplemented by an evaluation of benthic foraminiferal zonations and the varying abundance of biogenic constituents. This Baja California Sur carbonate environment holds special relevance for the interpretation of analogous Neogene and Paleogene paleoenvironments marking major paleoclimatic and paleoceanographic events along the Pacific Coast of North America.

  9. Modern carbonate sediments and environments of the LaPaz region, Baja California Sur, Mexico

    SciTech Connect

    Halfar, J.; Ingle, J.C. Jr. ); Cruz-Orozco, R. ); Godinez-Orta, L. )

    1996-01-01

    The Gulf of California represents one of the most productive and unique marginal seas in the world. The mouth of the Gulf captures warm equatorial water while annual wind patterns assure major upwelling of nutrient-rich water leading to a rich marine biota. These conditions have created a wide array of tropical through warm temperate carbonate environments. The most unusual of these environments is located in the La Paz region of Baja California Sur where tropical-subtropical water temperatures and low rainfall have allowed growth of corals, calcareous red algae, and other shelled invertebrates to form a carbonate bank environment. Sampling and mapping transacts in shallow bays north of La Paz and on the adjacent Espiritu Santo island have revealed a full spectrum of subenvironments including mangrove bordered, terrigenous mud dominated coastal zones, which grade into carbonate tidal flats. In addition, single coral heads as well as incipient reef structures constructed by Porites and Pocillopora coral are present in deeper water areas. Coralline red algae, which are increasingly utilized for paleoenvironmental reconstructions, grow in high abundance on coral debris and in soft sediments and turn out to be main contributors to the La Paz carbonates. Analysis of siliciclastic admixtures, grain size and organic carbon content allow a classification of distinct environments. These data are supplemented by an evaluation of benthic foraminiferal zonations and the varying abundance of biogenic constituents. This Baja California Sur carbonate environment holds special relevance for the interpretation of analogous Neogene and Paleogene paleoenvironments marking major paleoclimatic and paleoceanographic events along the Pacific Coast of North America.

  10. Etude Bacteriologique sur 30 Mois dans un Service de Brulés

    PubMed Central

    Chaibdraa, A.; Bentakouk, M.C.

    2008-01-01

    Summary Le pronostic des brûlures est souvent tributaire de complications infectieuses. Les objectifs de cette étude préliminaire rétrospective sont une évaluation de la flore microbienne et ses fluctuations selon la durée d'hospitalisation chez les patients du Centre des brûlés adultes de Annaba (Algérie). Ce travail porte sur 633 prélèvements microbiologiques positifs obtenus entre juin 2003 (inauguration du service) et décembre 2005. Selon le site de prélèvement la répartition est: cutané (78%), hémoculture (9%), prélèvement trachéo-bronchique (4%), uroculture (3%), sonde urinaire (3%), cathéter(3%). Les germes isolés sont: les staphylocoques (58%), les Pseudomonas (20%), le Candida albicans (5%), l'Acinetobacter (3%) et les autres germes (14%). Parmi les staphylocoques et les Pseudomonas recensés, respectivement 19% et 11% sont isolés la première semaine, contre 43% et 52% au-delà de 21 jours. Ces résultats confrontés aux données de la littérature confirment la prédominance du staphylocoque et du Pseudomonas. Le risque de contamination à partir des techniques invasives de réanimation est commun à toutes les équipes. La prolifération bactérienne est en relation avec la durée d'hospitalisation. Ces constatations doivent nous inciter à tirer bénéfice de l'expérience des autres services, en particulier sur les moyens, accessibles, de prévention de l'infection nosocomiale. PMID:21991102

  11. Breaking bad news and discussing death.

    PubMed

    Ambuel, B; Mazzone, M F

    2001-06-01

    The ability to discuss bad news with a patient and family is one clinical skill that is essential to providing effective end-of-life care. Patients and families value direct, nontechnical explanations that are given by a physician with compassion and kindness. Patients and families also value time to talk, express their feelings and ask questions. The authors review research on delivering bad news, then describe a six step process to guide physicians in discussing bad news with patients: (1) create an appropriate environment; (2) open the meeting; (3) discuss the news; (4) develop a follow-up plan; (5) document the conference; and (6) engage in self-reflection.

  12. Exploring the Use of Discussion Strategies and Labels in Asynchronous Online Discussion

    ERIC Educational Resources Information Center

    Gao, Fei

    2014-01-01

    Drawing on research in constrained online discussion environments and strategy instruction, this approach combines explicit instruction on discussion strategies with the use of post type labels. In a trial of this approach in an online course, students actively used the discussion strategies and post type labels in their discussions. Analysis of…

  13. An Elementary Discussion of Chemical Equilibrium.

    ERIC Educational Resources Information Center

    David, Carl W.

    1988-01-01

    This discussion uses a more difficult reaction as the prototype to derive the standard equation for chemical equilibrium. It can be used by students who can understand and use partial derivatives. (CW)

  14. Teaching Organizational Behavior Through Discussion Groups

    ERIC Educational Resources Information Center

    Fineman, Stephen; Hamblin, Anthony C.

    1978-01-01

    An educational experiment in teaching organizational behavior to undergraduates in England is reported, with focus on the value and limitations of a systematic form of discussion-group learning based upon a framework outlined by Fawcett Hill. (LBH)

  15. Dr. Irvin Yalom Discusses Group Psychotherapy.

    ERIC Educational Resources Information Center

    Forester-Miller, Holly

    1989-01-01

    In this interview, Dr. Irvin Yalom, director of the Adult Psychiatry Clinic at Stanford University School of Medicine, discusses his beginnings as a group psychotherapist, current issues in group work, and the future of group work. (Author/TE)

  16. Development of China's fiber optic technology discussed

    NASA Astrophysics Data System (ADS)

    Bai, Q.

    1986-04-01

    Fiber optic technology is a new transmission technology having the outstanding advantages of low loss, high capacity, no magnetic interference, all-dielectric transmission, small size, and light weight. Research into fiber optic technology began in the mid-1970's in China. The scope of applications for fiber optic communications systems is divided into three categories: junction lines, trunk lines, and subscriber lines. Each of the categories are briefly discussed. The advantages and economic suitability of fiber optics are discussed.

  17. Discussion groups on the Internet: journaling.

    PubMed

    Till, J E

    1995-09-01

    Interactive communication on the Internet, as illustrated by the e-mail-based breast cancer discussion group, provides an alternative to the telephone, the fax machine and regular mail, and is a resource for communications research, the potential of which is only beginning to be appreciated. At least some of the messages posted to such discussion groups could be regarded as a form of "journaling". Such messages are eminently suitable for qualitative data analysis.

  18. A Discussion of Knowledge Based Design

    NASA Technical Reports Server (NTRS)

    Wood, Richard M.; Bauer, Steven X. S.

    1999-01-01

    A discussion of knowledge and Knowledge- Based design as related to the design of aircraft is presented. The paper discusses the perceived problem with existing design studies and introduces the concepts of design and knowledge for a Knowledge- Based design system. A review of several Knowledge-Based design activities is provided. A Virtual Reality, Knowledge-Based system is proposed and reviewed. The feasibility of Virtual Reality to improve the efficiency and effectiveness of aerodynamic and multidisciplinary design, evaluation, and analysis of aircraft through the coupling of virtual reality technology and a Knowledge-Based design system is also reviewed. The final section of the paper discusses future directions for design and the role of Knowledge-Based design.

  19. Evaluation d'impact sur la santé et évaluation d'impact sur l'équité en santé : éventail de pratiques et questions de recherche.

    PubMed

    Villeval, Mélanie; Bidault, Elsa; Lang, Thierry

    2016-09-01

    L'Evaluation d'Impact sur la Santé (EIS) se développe au niveau international et est encore au stade émergent en France. Elle vise à évaluer les effets positifs et négatifs potentiels d'un projet, d'un programme ou d'une politique sur la santé. L'objectif est de produire des recommandations en direction des décideurs, afin d'en maximiser les effets positifs et d'en diminuer les effets négatifs. L'EIS est un moyen particulièrement intéressant d'action sur les déterminants de la santé au-delà des comportements individuels et du système de santé. Les politiques de logement, de transport, de solidarité, économiques, etc. ont, en effet, des impacts souvent non prévus sur la santé. Au-delà des effets sur la santé, l'EIS doit aussi permettre d'apprécier la distribution de ces effets dans la population.Si la préoccupation pour l'équité en santé est centrale dans l'EIS, elle reste cependant difficilement traduite en pratique. Face à cette difficulté, des démarches d'évaluation d'impact ont été développées pour renforcer la prise en compte de l'équité à chaque étape de l'EIS ou « Equity Focused Health Impact Assessment », ou prendre en compte les impacts sur les inégalités de santé de façon spécifique. Ainsi, l'Evaluation de l'Impact sur l'Equité en Santé (EIES) semble, par exemple, particulièrement intéressante pour évaluer l'impact sur les inégalités de projets dans le champ sanitaire.L'EIS et l'EIES posent de nombreuses questions de recherche, notamment autour de la réunion, dans une même démarche, du politique, du citoyen et de l'expert. La participation des populations vulnérables potentiellement affectées par la politique évaluée est une valeur centrale de l'EIS, mais pose des questions d'acceptabilité sociale. La collaboration avec les décideurs politiques est également un enjeu majeur. Les difficultés méthodologiques, notamment de quantification des impacts, peuvent constituer des freins à la promotion

  20. Evaluation d'impact sur la santé et évaluation d'impact sur l'équité en santé : éventail de pratiques et questions de recherche.

    PubMed

    Villeval, Mélanie; Bidault, Elsa; Lang, Thierry

    2016-09-01

    L'Evaluation d'Impact sur la Santé (EIS) se développe au niveau international et est encore au stade émergent en France. Elle vise à évaluer les effets positifs et négatifs potentiels d'un projet, d'un programme ou d'une politique sur la santé. L'objectif est de produire des recommandations en direction des décideurs, afin d'en maximiser les effets positifs et d'en diminuer les effets négatifs. L'EIS est un moyen particulièrement intéressant d'action sur les déterminants de la santé au-delà des comportements individuels et du système de santé. Les politiques de logement, de transport, de solidarité, économiques, etc. ont, en effet, des impacts souvent non prévus sur la santé. Au-delà des effets sur la santé, l'EIS doit aussi permettre d'apprécier la distribution de ces effets dans la population.Si la préoccupation pour l'équité en santé est centrale dans l'EIS, elle reste cependant difficilement traduite en pratique. Face à cette difficulté, des démarches d'évaluation d'impact ont été développées pour renforcer la prise en compte de l'équité à chaque étape de l'EIS ou « Equity Focused Health Impact Assessment », ou prendre en compte les impacts sur les inégalités de santé de façon spécifique. Ainsi, l'Evaluation de l'Impact sur l'Equité en Santé (EIES) semble, par exemple, particulièrement intéressante pour évaluer l'impact sur les inégalités de projets dans le champ sanitaire.L'EIS et l'EIES posent de nombreuses questions de recherche, notamment autour de la réunion, dans une même démarche, du politique, du citoyen et de l'expert. La participation des populations vulnérables potentiellement affectées par la politique évaluée est une valeur centrale de l'EIS, mais pose des questions d'acceptabilité sociale. La collaboration avec les décideurs politiques est également un enjeu majeur. Les difficultés méthodologiques, notamment de quantification des impacts, peuvent constituer des freins à la promotion

  1. Thermal-maturity trends within Franciscan rocks near Big Sur, California: Implications for offset along the San Gregorio San Simeon Hosgri fault zone

    NASA Astrophysics Data System (ADS)

    Underwood, Michael B.; Laughland, Matthew M.; Shelton, Kevin L.; Sedlock, Richard L.

    1995-09-01

    Conventional neotectonic interpretations place the Lucia and Point Sur subterranes of the Franciscan subduction complex on opposite sides of the San Gregorio San Simeon Hosgri dextral fault system and connect that system through the Sur fault zone. Our reconstructed paleotemperature contours, however, are not offset across the San Simeon segment, so differential displacement between the subterranes after peak heating appears to have been negligible. One explanation is that dextral slip on the faults has totaled only 5 10 km. A second possibility is that a discrete Hosgri San Simeon segment extends offshore of the amalgamated Point Sur and Lucia subterranes and that an en echelon stepover transfers dextral slip eastward to the San Gregorio Palo Colorado segment. In either case, the Sur fault zone appears to play a relatively insignificant role in the late Cenozoic tectonic evolution of central California.

  2. Discussion of difficult assessment cases: psychodynamic perspectives.

    PubMed

    Yalof, Jed

    2015-01-01

    I discuss the papers of Kleiger (this issue), Husain (this issue), and Bram (this issue), each of whom described their personality assessment of a very challenging case. Each case illustrates the way in which experienced personality assessors integrate psychoanalytic theory with clinical reasoning, multi-method assessment, and an understanding of the patient-examiner relationship when evaluating patients with serious psychiatric needs. The discussion elaborates particular aspects of each case and integrates the different estuaries through which personality assessors use psychoanalytic theory to develop diagnostic and treatment inferences. PMID:25746100

  3. L'argumentation dans des discussions d'adolescents (Argumentation in Adolescents' Discussions).

    ERIC Educational Resources Information Center

    Chevalier, Jean-Claude; Delesalle, Simone

    1979-01-01

    Reports on an experiment in which three groups of adolescents discussed the status of women. The discussions were recorded for the purpose of using the recordings as pedagogical tools in French instruction. (AM)

  4. Overview of 3D Documentation Data and Tools available for Archaeological Researches: case study of the Romanesque Church of Dugny-sur-Meuse (France)

    NASA Astrophysics Data System (ADS)

    Macher, H.; Grussenmeyer, P.; Kraemer, C.; Guillemin, S.

    2015-08-01

    In this paper, the 3D documentation of the full structure of the Romanesque church of Dugny-sur-Meuse is discussed. In 2012 and 2013, a 3D recording project was carried out under the supervision of the Photogrammetry and Geomatics Research Group from INSA Strasbourg (France) in cooperation with C. Kraemer, archaeologist from Nancy (France). The goal of the project was on one hand to propose new solutions and tools to the archaeologists in charge of the project especially for stone by stone measurements. On the other hand, a simplified 3D model was required by the local authorities for communication purposes. To achieve these goals several techniques were applied namely GNSS measurements and accurate traverse networks, photogrammetric recordings and terrestrial laser scanning acquisitions. The various acquired data are presented in this paper. Based on these data, several deliverables are also proposed. The generation of orthoimages from plane as well as cylindrical surfaces is considered. Moreover, the workflow for the creation of a 3D simplified model is also presented.

  5. First record of a louse fly, Stilbometopa impressa (Bigot), and new host for Microlynchia pusilla (Speiser) (Hippoboscidae) from the Cape Region, Baja California Sur, México.

    PubMed

    Llinas, J; Jiménez, M L

    1996-04-01

    Nine of thirty California quail (Callipepla californica achrustera) captured in autumn of 1992, 17 km west of La Paz, Baja California Sur, México, were parasitized by louse flies. We identified eight Microlynchia pusilla and three Stilbometopa impressa from 30 quails in the ratio of 2.75:1. These are the first records of S. impressa for Cape Region and the first time either fly has been reported from the California quail in Baja California Sur. PMID:8722274

  6. Promoting Discussion in Peer Instruction: Discussion Partner Assignment and Accountability Scoring Mechanisms

    ERIC Educational Resources Information Center

    Chou, Chih-Yueh; Lin, Pin-Hsun

    2015-01-01

    Peer instruction (PI) involves students answering questions and peer discussion learning activities. PI can enhance student performance and engagement in classroom instruction. However, some students do not engage in the discussions. This study proposes two mechanisms, discussion partner assignment and accountability scoring mechanisms, to form…

  7. The Misuse of Non-Argumentative Approaches in Practical Ethics Discussions: A Dialogue with Discussion

    ERIC Educational Resources Information Center

    Gough, Jim

    2005-01-01

    This paper presents a description of a set of classroom discussions with students in an introductory college ethics course, with typical responses from the instructor to the students, as well as post discussion observations by the writer/instructor. It is intended as an open-ended paper, one which introduces the reader to discussions and invites…

  8. Literature Discussion as Positioning: Examining Positions in Dialogic Discussions in a Third-Grade Classroom

    ERIC Educational Resources Information Center

    Wee, Jongsun

    2010-01-01

    The purpose of the study is to examine positions of students and a teacher in dialogic discussion. In this study, dialogic discussion was defined with Bakhtin's (1981) dialogism, Nystrand's (1997) explanation of dialogically organized instruction, and Mercer's (1995) explanation of Exploratory Talk. Studies about literature discussion in…

  9. Investigating Algebraic Procedures Using Discussion and Writing

    ERIC Educational Resources Information Center

    Harper, Jonathan; Ford, Jeffrey

    2012-01-01

    This study reports on the implementation of an intermediate algebra curriculum centered on a framework of student-centered questions designed to investigate algebraic procedures. Instructional activities were designed to build discourse in the small-group discussion meetings of the course. Students were assigned writing prompts to emphasize the…

  10. Alice, Greenfoot, and Scratch--A Discussion

    ERIC Educational Resources Information Center

    Utting, Ian; Cooper, Stephen; Kolling, Michael; Maloney, John; Resnick, Mitchel

    2010-01-01

    This article distills a discussion about the goals, mechanisms, and effects of three environments which aim to support the acquisition and development of computing concepts (problem solving and programming) in pre-University and non-technical students: Alice, Greenfoot, and Scratch. The conversation started in a special session on the topic at the…

  11. From Good to Great: Discussion Starter Tool

    ERIC Educational Resources Information Center

    Center on Great Teachers and Leaders, 2014

    2014-01-01

    In the report "From Good to Great: Exemplary Teachers Share Perspectives on Increasing Teacher Effectiveness across the Career Continuum," (See full report in ERIC at ED555657) National and State Teachers of the Year shared their views on what helped them become great teachers. This accompanying "Discussion Starter Tool" builds…

  12. Discussion Paper on Digital Copyright Issues.

    ERIC Educational Resources Information Center

    2001

    The Copyright Forum serves as a venue for the discussion of digital copyright issues of interest to Canadian educational institutions, libraries, archives, and museums. The Forum currently comprises 13 national associations. The members of the participating associations are both creators and users of digital intellectual content, and a number of…

  13. Examining the Doctoral Thesis: A Discussion

    ERIC Educational Resources Information Center

    Carter, Susan

    2008-01-01

    The examination of doctoral theses controls an important academic threshold, yet practices are often private, codes non-specific, and individuals isolated. This article adds to recent investigation of the examination culture by reporting informal panel discussion amongst a total of 23 University of Auckland (New Zealand) faculty members as to…

  14. NEUROTOXICITY OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE): DISCUSSION PAPER

    EPA Science Inventory

    This paper is a background document for a meeting of neurotoxicity experts to discuss the central nervous system effects of exposure to perchloroethylene (perc). The document reviews the literature on neurological testing of people exposed to perc occupationally in dry cleanin...

  15. Workplace Mobbing: A Discussion for Librarians

    ERIC Educational Resources Information Center

    Hecker, Thomas E.

    2007-01-01

    Workplace mobbing occurs in libraries but is usually unrecognized and unchecked because the phenomenon has not been described and given a name. This discussion provides the library profession with an overview but also with specific background details to assist with recognizing mobbing and preventing severe harm to employees and organizations.

  16. Dr. von Braun Discusses 'Bottle Suit' Concept

    NASA Technical Reports Server (NTRS)

    1954-01-01

    Dr. Wernher von Braun (center), then Chief of the Guided Missile Development Division at Redstone Arsenal, Alabama, discusses a 'bottle suit' model with Dr. Heinz Haber (left), an expert on aviation medicine, and Willey Ley, a science writer on rocketry and space exploration. The three men were at the Disney studios appearing in the motion picture, entitled 'Man in Space.'

  17. Multiphase Method for Analysing Online Discussions

    ERIC Educational Resources Information Center

    Häkkinen, P.

    2013-01-01

    Several studies have analysed and assessed online performance and discourse using quantitative and qualitative methods. Quantitative measures have typically included the analysis of participation rates and learning outcomes in terms of grades. Qualitative measures of postings, discussions and context features aim to give insights into the nature…

  18. Measuring Faculty Participation in Asynchronous Discussion Forums.

    ERIC Educational Resources Information Center

    Blignaut, A. Signet; Trollip, Stanley R.

    2003-01-01

    A taxonomy of types of faculty participation in online course discussions was developed and a survey of 18 online business instructors and administrators was used to develop expectations for type and number of feedback messages. Results were used to analyze business courses and develop guidelines for teachers' role. (Contains 13 references.) (SK)

  19. What Is Formation? A Conceptual Discussion

    ERIC Educational Resources Information Center

    Sutphen, Molly; de Lange, Thomas

    2015-01-01

    This paper addresses the principles and connotations of the term "formation." In our discussion of formation, we draw on different disciplines in order to widen and deepen our understanding of the concept of formation. We also mirror the formation concept against comparable terms and draw on studies in which it has been applied in…

  20. 33 CFR 214.6 - Discussion.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... SUPPLIES OF DRINKING WATER § 214.6 Discussion. (a) The amendment provides for furnishing emergency supplies of drinking water. The method of furnishing those supplies is not provided for in the amendment, and... providing emergency supplies of clean drinking water. Sewage treatment and disposal, and other...

  1. 33 CFR 214.6 - Discussion.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... SUPPLIES OF DRINKING WATER § 214.6 Discussion. (a) The amendment provides for furnishing emergency supplies of drinking water. The method of furnishing those supplies is not provided for in the amendment, and... providing emergency supplies of clean drinking water. Sewage treatment and disposal, and other...

  2. 33 CFR 214.6 - Discussion.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... SUPPLIES OF DRINKING WATER § 214.6 Discussion. (a) The amendment provides for furnishing emergency supplies of drinking water. The method of furnishing those supplies is not provided for in the amendment, and... providing emergency supplies of clean drinking water. Sewage treatment and disposal, and other...

  3. Using Online Discussion Boards for Senior Internships

    ERIC Educational Resources Information Center

    Hurd, Amy R.; Beggs, Brent A.; Elkins, Daniel J.

    2012-01-01

    Senior internships in parks and recreation are an opportunity to put classroom knowledge to practice. However, this is likely the first time students are in a learning environment without the immediate support of faculty and peers. To alleviate this issue, online discussion boards were used to connect interns who were located across the country.…

  4. Discussing the theological grounds of moral principles.

    PubMed

    Heller, Jan C

    2005-01-01

    Discussing the theological beliefs that ground Catholic moral principles can make some people uncomfortable, even while others will appreciate it. But these reactions will sometimes be revealed not as the emotions they are, but as objections to the relative independence or dependence of morality on foundational beliefs. In the end, context should dictate whether one displays the theological beliefs that ground Catholic moral principles.

  5. Interaction in online interprofessional education case discussions.

    PubMed

    Waterston, Rosemary

    2011-07-01

    This study investigated online interaction within a curriculum unit at the University of Toronto, Canada that included an interprofessional case study discussion in a mixed-mode (face-to-face and online) format. Nine of the 81 teams that completed the four-day curriculum were selected for detailed review based on the attitudes students expressed on a survey about the value of collaborating online for enhancing their appreciation of other health care professions. Five of the teams selected were 'positive' and four were 'negative'. The responses to other survey items by members of these teams were then compared, as well as their message posting patterns and the content of their online discussions. Differences between the two sets were situated within a theoretical framework drawn from the contact theory, social interdependence theory, and the Community of Inquiry model. Institutional support in the form of facilitator involvement, individual predispositions to online and group learning, the group composition, the learning materials, task and assignment, and technical factors all affected the levels of participation online. Discourse and organizational techniques were identified that related to interactivity within the online discussions. These findings can help curriculum planners design interprofessional case studies that encourage the interactivity required for successful online discussions.

  6. Discussion Dynamics: An Analysis of Classroom Teaching.

    ERIC Educational Resources Information Center

    Johnson, Mary Canice

    Dynamics of discussion in the classroom are analyzed based on data from 64 classrooms in Georgia, Alabama, and Florida. Among the discourse problems considered are the separation of answers from questions, the relationship between the presupposition of an utterance and the speaker/hearer assumptions, and the relationship between utterance form and…

  7. Corruptness in Education: A Tentative Discussion

    ERIC Educational Resources Information Center

    Dongping, Yang

    2004-01-01

    With more and more instances of corruptness coming to light in the field of education, corruptness in education has become an intense "hot point" of concern in society. This article is a tentative exploration into this matter. In this article, the author discusses the categories of the corruptness in education that has found widespread publicity…

  8. Writing Conversations: Fostering Metalinguistic Discussion about Writing

    ERIC Educational Resources Information Center

    Myhill, Debra; Jones, Susan; Wilson, Anthony

    2016-01-01

    This article draws on data from a national study, involving an experimental intervention with 54 schools across the country, in which teachers were mentored in a pedagogical approach involving explicit attention to grammatical choices and which advocated high-level metalinguistic discussion about textual choices. The research focused upon primary…

  9. Young Scientists Discuss Recent Advances, Future Challenges.

    ERIC Educational Resources Information Center

    Baum, Rudy M.

    1989-01-01

    Discusses a National Academy of Science forum at which a group of outstanding young researchers in astronomy, molecular and developmental biology, physics, chemistry, mathematics, atmospheric science, and materials science met for three days of formal presentations and informal conversations. Provides a short synopsis of major speakers. (MVL)

  10. Group Discussion and Cooperation in Social Dilemmas.

    ERIC Educational Resources Information Center

    Bouas, Kelly S.; Komorita, S. S.

    1996-01-01

    Face-to-face discussion has been shown to increase cooperation behavior in social dilemmas. Two general explanations of this effect were tested: group identity and perception of consensus. Female undergraduate students (N=160) participated in four-person groups in one of four experimental conditions. Findings indicate the most plausible…

  11. A Discussion of Population Invariance of Equating

    ERIC Educational Resources Information Center

    Petersen, Nancy S.

    2008-01-01

    This article discusses the five studies included in this issue. Each article addressed the same topic, population invariance of equating. They all used data from major standardized testing programs, and they all used essentially the same statistics to evaluate their results, namely, the root mean square difference and root expected mean square…

  12. Online Discussion Assignments Improve Students' Class Preparation

    ERIC Educational Resources Information Center

    Lineweaver, Tara T.

    2010-01-01

    To increase the number of students who read the text before class and to promote student interaction centering on text material, I developed an online discussion assignment as a required component of a cognitive psychology course. Across 2 studies, this assignment had a limited effect on examination performance, but students completing online…

  13. Discover Presidential Log Cabins. Teacher's Discussion Guide.

    ERIC Educational Resources Information Center

    National Park Service (Dept. of Interior), Washington, DC.

    Discover Presidential Log Cabins is a set of materials designed to help educate 6-8 grade students about the significance of three log cabin sites occupied by George Washington, Ulysses Grant, Abraham Lincoln, and Theodore Roosevelt. This teacher's discussion guide is intended for use as part of a larger, comprehensive social studies program, and…

  14. Janet Saltzman Chafetz Plenary: Discussant Comments

    ERIC Educational Resources Information Center

    Allen, Katherine R.

    2004-01-01

    Feminist ideas and practices permeate the consciousness, relationships, and politics of women and men across continents. Certainly, they are central to work in the scientific study of family structures and processes. It is exciting to engage in discussion and debate with other feminist scholars about the relative contributions of feminist theories…

  15. School PE through Internet Discussion Forums

    ERIC Educational Resources Information Center

    Lauritsalo, Kirsti; Sääkslahti, Arja; Rasku-Puttonen, Helena

    2015-01-01

    Background: Physical education is a subject that generates strong feelings and emotions, as can be seen in written accounts of PE experiences. It is also important to listen to students' voices in the research context. Nowadays, students can be listened to in a new way--through the Internet. Various discussion forums on the Internet make it…

  16. Theses "Discussion" Sections: A Structural Move Analysis

    ERIC Educational Resources Information Center

    Nodoushan, Mohammad Ali Salmani; Khakbaz, Nafiseh

    2011-01-01

    The current study aimed at finding the probable differences between the move structure of Iranian MA graduates' thesis discussion subgenres and those of their non-Iranian counterparts, on the one hand, and those of journal paper authors, on the other. It also aimed at identifying the moves that are considered obligatory, conventional, or optional…

  17. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    NASA Astrophysics Data System (ADS)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  18. Lignes directrices canadiennes sur la rhinosinusite bactérienne aiguë

    PubMed Central

    Kaplan, Alan

    2014-01-01

    Résumé Objectif Faire un résumé clinique des lignes directrices canadiennes sur la rhinosinusite bactérienne aiguë (RSBA) qui présente des éléments d’intérêt pour les médecins de famille. Source des données Les auteurs des lignes directrices ont effectué une recherche documentaire systématique et ont rédigé des recommandations. Une cote a été donnée à la fois en fonction de la fiabilité des données probantes et de la solidité des recommandations. On a sollicité les commentaires d’experts en la matière venant de l’extérieur, ainsi que l’aval de sociétés médicales canadiennes (Association pour la microbiologie médicale et l’infectiologie Canada, Société canadienne d’allergie et d’immunologie clinique, Société canadienne d’otorhinolaryngologie et de chirurgie cervicofaciale, Association canadienne des médecins d’urgence et Regroupement canadien des médecins de famille en santé respiratoire). Message principal Le diagnostic de la RSBA repose sur la présence de symptômes particuliers et leur durée; l’imagerie ou une culture n’est pas nécessaire dans les cas peu compliqués. Le traitement dépend de la gravité des symptômes, notamment avec des corticostéroïdes intranasaux (CSIN) recommandés comme monothérapie pour les cas de légers à modérés, quoique leurs bienfaits soient modestes. Le recours à des CSIN accompagnés d’antibiotiques est réservé aux patients qui ne répondent pas aux CSIN après 72 heures et comme traitement initial des patients dont les symptômes sont graves. Le choix de l’antibiotique doit tenir compte du pathogène soupçonné, du risque de résistance, des problèmes concomitants et des tendances locales de la résistance aux antimicrobiens. Des thérapies d’appoint comme l’irrigation nasale avec une solution saline sont recommandées. En présence de cas réfractaires au traitement, d’épisodes récurrents et de signes de complications, on devrait demander une

  19. Structural and functional insights into the stationary-phase survival protein SurE, an important virulence factor of Brucella abortus.

    PubMed

    Tarique, K F; Abdul Rehman, S A; Devi, S; Tomar, Priya; Gourinath, S

    2016-05-01

    The stationary-phase survival protein SurE from Brucella abortus (BaSurE) is a metal-dependent phosphatase that is essential for the survival of this bacterium in the stationary phase of its life cycle. Here, BaSurE has been biochemically characterized and its crystal structure has been determined to a resolution of 1.9 Å. BaSurE was found to be a robust enzyme, showing activity over wide ranges of temperature and pH and with various phosphoester substrates. The active biomolecule is a tetramer and each monomer was found to consist of two domains: an N-terminal domain, which forms an approximate α + β fold, and a C-terminal domain that belongs to the α/β class. The active site lies at the junction of these two domains and was identified by the presence of conserved negatively charged residues and a bound Mg(2+) ion. Comparisons of BaSurE with its homologues have revealed both common features and differences in this class of enzymes. The number and arrangement of some of the equivalent secondary structures, which are seen to differ between BaSurE and its homologues, are responsible for a difference in the size of the active-site area and the overall oligomeric state of this enzyme in other organisms. As it is absent in mammals, it has the potential to be a drug target.

  20. Structural and functional insights into the stationary-phase survival protein SurE, an important virulence factor of Brucella abortus.

    PubMed

    Tarique, K F; Abdul Rehman, S A; Devi, S; Tomar, Priya; Gourinath, S

    2016-05-01

    The stationary-phase survival protein SurE from Brucella abortus (BaSurE) is a metal-dependent phosphatase that is essential for the survival of this bacterium in the stationary phase of its life cycle. Here, BaSurE has been biochemically characterized and its crystal structure has been determined to a resolution of 1.9 Å. BaSurE was found to be a robust enzyme, showing activity over wide ranges of temperature and pH and with various phosphoester substrates. The active biomolecule is a tetramer and each monomer was found to consist of two domains: an N-terminal domain, which forms an approximate α + β fold, and a C-terminal domain that belongs to the α/β class. The active site lies at the junction of these two domains and was identified by the presence of conserved negatively charged residues and a bound Mg(2+) ion. Comparisons of BaSurE with its homologues have revealed both common features and differences in this class of enzymes. The number and arrangement of some of the equivalent secondary structures, which are seen to differ between BaSurE and its homologues, are responsible for a difference in the size of the active-site area and the overall oligomeric state of this enzyme in other organisms. As it is absent in mammals, it has the potential to be a drug target. PMID:27139831

  1. La violence sur les réseaux canadiens de télévision

    PubMed Central

    Paquette, Guy

    2003-01-01

    La question des effets de la violence à la télévision occupe une place très importante dans l’opinion publique depuis les vingt dernières années, et des centaines d’études y ont été consacrées. Plusieurs chercheurs concluent à une influence négative de cette violence sur le comportement. Le public, les diffuseurs et les autorités politiques ont tous endossé l’idée de réduire la quantité totale de violence présentée au petit écran – en particulier dans les émissions accessibles aux enfants. Nous avons analysé un millier d’émissions de fiction présentées entre 1993 et 2001 sur les principaux réseaux généralistes de télévision au Canada : TVA et TQS ainsi que CTV et Global pour les réseaux privés français et anglais, ainsi que Radio-Canada français et anglais pour les réseaux publics. La méthodologie utilisée est l’analyse de contenu classique, où l’acte de violence constitue l’unité d’analyse. Les données recueillies démontrent que la quantité de violence a augmenté régulièrement depuis 1993, malgré la volonté affirmée des télédiffuseurs de présenter une programmation moins violente. C’est le cas du nombre brut d’actes et du nombre d’actes à l’heure, qui est lui aussi en forte croissance. Les réseaux privés véhiculent trois fois plus de violence que les réseaux publics. On constate également qu’une très forte proportion d’actes de violence figure dans des émissions qui commencent avant 21 h, et que de nombreux enfants y sont probablement exposés. Nous signalons finalement la place de plus en plus importante occupée par la violence psychologique. PMID:20020031

  2. Mise à jour sur l’utilisation clinique de la buprénorphine

    PubMed Central

    Ducharme, Simon; Fraser, Ronald; Gill, Kathryn

    2012-01-01

    Résumé Objectif Examiner les données scientifiques actuelles sur la buprénorphine-naloxone pour le traitement des troubles liés aux opioïdes, en insistant sur le contexte des soins primaires. Qualité des données On a fait une recension dans MEDLINE et la base de données Cochrane des synthèses critiques. Les données probantes sont surtout de niveau I. Message principal La buprénorphine est un agoniste partiel des récepteurs μ des opioïdes et un antagoniste des récepteurs κ des opioïdes ayant une longue demi-vie et un potentiel moins grand que la méthadone d’entraîner un usage abusif. Pour une désintoxication, la buprénorphine est au moins équivalente à la méthadone et supérieure à la clonidine. Comme thérapie de substitution, la buprénorphine est clairement supérieure au placebo. La méthadone comporte de légers avantages en ce qui a trait à la rétention en thérapie, mais une approche par étape en utilisant initialement la buprénorphine-naloxone est aussi efficace. Il est possible, sécuritaire et efficace de recourir à la buprénorphine en milieu de soins primaires. On peut obtenir l’autorisation de prescrire de la buprénorphine après avoir suivi une formation en ligne. Conclusion La buprénorphine est un agent sécuritaire et efficace pour la désintoxication en cas de dépendance aux opioïdes. Elle peut servir d’agent de première intention dans les programmes de thérapie de substitution, en raison de son potentiel plus faible d’usage abusif en comparaison d’autres opioïdes. Son efficacité en milieux de soins primaires en fait un outil thérapeutique utile pour les médecins de famille.

  3. Bio-optical profile data report coastal transition zone program, R/V Point Sur, June 15-28, 1987

    NASA Technical Reports Server (NTRS)

    Davis, Curtiss O.; Rhea, W. Joseph

    1990-01-01

    Twenty vertical profiles of the bio-optical properties of the ocean were made during a research cruise on the R/V Point Sur, June 15 to 28, 1987, as part of the Coastal Transition Zone Program off Point Arena, California. Extracted chlorophyll values were also measured at some stations to provide calibration data for the in situ fluorometer. This summary provides investigators with an overview of the data collected. The entire data set is available in digital form.

  4. Map showing coastal cliff retreat rates along the Big Sur coast, Monterey and San Luis Obispo Counties, California

    USGS Publications Warehouse

    Hapke, Cheryl J.; Green, Krystal R.

    2004-01-01

    The average coastal cliff retreat rate along the Big Sur coast is 18 ? 6 cm/yr as measured over a 52-year time period. The erosion reference features measured as the cliff edge include the well-defined cliff edges common to marine terraces, slight breaks in the slope defining the upper edge of the active lower slope, and the road grade. Cliff erosion and retreat are focused in isolated erosion hotspots that account for most of the calculated average retreat.

  5. Quantum clock: A critical discussion on spacetime

    NASA Astrophysics Data System (ADS)

    Burderi, Luciano; Di Salvo, Tiziana; Iaria, Rosario

    2016-03-01

    We critically discuss the measure of very short time intervals. By means of a Gedankenexperiment, we describe an ideal clock based on the occurrence of completely random events. Many previous thought experiments have suggested fundamental Planck-scale limits on measurements of distance and time. Here we present a new type of thought experiment, based on a different type of clock, that provide further support for the existence of such limits. We show that the minimum time interval Δ t that this clock can measure scales as the inverse of its size Δ r . This implies an uncertainty relation between space and time: Δ r Δ t >G ℏ/c4, where G , ℏ, and c are the gravitational constant, the reduced Planck constant, and the speed of light, respectively. We outline and briefly discuss the implications of this uncertainty conjecture.

  6. How to write a discussion section?

    PubMed

    Şanlı, Öner; Erdem, Selçuk; Tefik, Tzevat

    2013-09-01

    Writing manuscripts to describe study outcomes, although not easy, is the main task of an academician. The aim of the present review is to outline the main aspects of writing the discussion section of a manuscript. Additionally, we address various issues regarding manuscripts in general. It is advisable to work on a manuscript regularly to avoid losing familiarity with the article. On principle, simple, clear and effective language should be used throughout the text. In addition, a pre-peer review process is recommended to obtain feedback on the manuscript. The discussion section can be written in 3 parts: an introductory paragraph, intermediate paragraphs and a conclusion paragraph. For intermediate paragraphs, a "divide and conquer" approach, meaning a full paragraph describing each of the study endpoints, can be used. In conclusion, academic writing is similar to other skills, and practice makes perfect. PMID:26328131

  7. Career Opportunities for Physicists: Panel Discussion

    NASA Astrophysics Data System (ADS)

    2016-03-01

    We live in a world full of opportunity for physics graduates. Join us for a unique opportunity to learn about some of these opportunities from our diverse panel of working physicists from industrial, national lab, and academic sectors. Topics of discussion will include panelists' daily experiences, how physics serves them in their career, and advice to students interested in following a similar path. Light refreshments will be served.

  8. Discussion on the standardization of time service

    NASA Astrophysics Data System (ADS)

    Chen, Hong-Qing; Guo, Qing-Sheng; Dou, Zhong

    2002-12-01

    A guarantee system for unified time standard and qualified time service technique is essential for an independent country. Establishing the national time standard, working out the technical specifications for standard time transmitting and service, and perfecting the national time service system are urgently needed in China after joining WTO. The task of time service standardization and its significance are introduced. The content of technical specification and the coordination with related national and international rules and standards are discussed in this paper.

  9. Discussion of long-range weather prediction

    SciTech Connect

    Canavan, G.H.

    1998-09-10

    A group of scientists at Los Alamos have held a series of discussions of the issues in and prospects for improvements in Long-range Weather Predictions Enabled by Proving of the Atmosphere at High Space-Time Resolution. The group contained the requisite skills for a full evaluation, although this report presents only an informal discussion of the main technical issues. The group discussed all aspects of the proposal, which are grouped below into the headings: (1) predictability; (2) sensors and satellites, (3) DIAL and atmospheric sensing; (4) localized transponders; and (5) summary and integration. Briefly, the group agreed that the relative paucity of observations of the state of the atmosphere severely inhibits the accuracy of weather forecasts, and any program that leads to a more dense and uniform observational network is welcome. As shown in Long-range Weather more dense and uniform observational network is welcome. As shown in Long-range Weather Predictions, the pay-back of accurate long-range forecasts should more than justify the expenditure associated with improved observations and forecast models required. The essential step is to show that the needed technologies are available for field test and space qualification.

  10. The debate about death: an imperishable discussion?

    PubMed

    Bacigalupo, Félix; Huerta, Daniela; Montefusco-Siegmund, Rodrigo

    2007-01-01

    In this concise review we discuss some of the complex edges of the concept of death that arose after the notorious advances in science and medicine over the last 50 years, in which the classical cardio-pulmonary criteria have led to the neurological criteria of death. New complicated questions like the definition of death and the operational criteria for diagnosing it have arisen and we think that they are far from being adequately and satisfactorily solved. A number of important issues--like the reliability and differences between cardio-pulmonary versus brain based criteria of death, if death is an event or a process, the meaning of integration and irreversibility--have not yet received sufficient attention. Here we have approached the death problem from two (biological) complex system perspectives: the organism level and the cellular-molecular level. We also discuss issues from a third systemic approach, that is, the entire society, thus involving legal, religious, bioethical and political aspects of death. Our aim is to integrate new perspectives in order to promote further discussion on these critical yet frequently neglected issues.

  11. Interactive Workshop Discusses Nonlinear Waves and Chaos

    NASA Astrophysics Data System (ADS)

    Tsurutani, Bruce; Morales, George; Passot, Thierry

    2010-07-01

    Eighth International Nonlinear Wave Workshop; La Jolla, California, 1-5 March 2010; Nonlinear waves and chaos were the focus of a weeklong series of informal and interactive discussions at the Eighth International Nonlinear Wave Workshop (NWW8), held in California. The workshop gathered nonlinear plasma and water wave experts from the United States, France, Czech Republic, Germany, Greece, Holland, India, and Japan. Attendees were from the fields of space, laboratory, and fusion plasma physics, astrophysics, and applied mathematics. Special focus was placed on nonlinear waves and turbulence in the terrestrial environment as well as in the interstellar medium from observational, laboratory, and theoretical perspectives. Discussions covered temperature anisotropies and related instabilities, the properties and origin of the so-called dissipation range, and various coherent structures of electromagnetic as well as electrostatic nature. Reconnection and shocks were also topics of discussion, as were properties of magnetospheric whistler and chorus waves. Examples and analysis techniques for superdiffusion and subdiffusion were identified. On this last topic, a good exchange of ideas and results occurred between a water wave expert and a plasma expert, with the rest of the audience listening intently.

  12. Abdomen aigu sur une torsion de rate ectopique: à propos d'un cas

    PubMed Central

    Khalid, Elhattabi; Fatimazahra, Bensardi; Rachid, Lefriyekh; Abdelaziz, Fadil; Mohamed, Lahkim; Nadia, Benissa; Driss, Khaiz; Saad, Berrada; Najib, Zerouali Ouariti

    2012-01-01

    La rate ectopique est une entité rare dont l'incidence est mal connue. La torsion de son pédicule est une complication grave, qui doit bénéficier d'un diagnostic précoce; évitant ainsi la splénectomie surtout chez des patients jeunes. Nous rapportons le cas d'une patiente âgée de 39 ans; admise aux urgences dans un tableau d'abdomen aigu chirurgical, l'examen clinique, l’échographie et la tomodensitométrie abdominale ont contribué au diagnostic de torsion d'une rate ectopique en position hypogastrique, la splénectomie a été réalisée devant la découverte peropératoire de taches de nécrose sur la rate tordue. Le diagnostic de torsion d'une rate ectopique doit être suspecté devant l'association d'un abdomen aigu et la palpation d'une masse abdominale. L’échographie et la tomodensitométrie abdominale confirment le diagnostic. Le traitement est chirurgical; il consiste en une splénopexie qui est plus approprié. En présence de nécrose, la splénectomie doit être réalisée aussi bien par voie laparoscopique que par laparotomie. PMID:22655096

  13. The two Coissac's novels : l'Envol and Sur la Lune

    NASA Astrophysics Data System (ADS)

    Villain, Jacques

    2002-01-01

    Coissac wrote two novels with his friend Charles Rouch.: "L'Envol" in 1934 and "Sur la Lune" in 1935. In these books he describes the preparation of the lunar rocket weigthing 3000 tons and powered by solid propellants. This rocket is launched from a base built at the top of a peruvian volcano. The seven men crew (5 french and one american) is sent to the Moon in a 45 tons command module from which two lunar modules can be separated and can descent to the lunar surface. Coissac describes along the trajectory the means to guide and control the rocket. The exploration of the Moon is done with bicycles ans suits. The explorers meet strange animals and strange people living under ground like termites in perfect love and happiness. After having explored the two faces of the Moon, the lunar modules leave the Moon for a docking with the main vehicle waiting on a lunar orbit and the crew comes back to the Earth. The spacecraft lands in the Pacific Ocean. Except the direct flight from Earth to the Moon, the travel to the Moon proposed by Coissac is very similar to that of Apollo but more than thirty years earlier.

  14. The Reality of Neandertal Symbolic Behavior at the Grotte du Renne, Arcy-sur-Cure, France

    PubMed Central

    Caron, François; d'Errico, Francesco; Del Moral, Pierre; Santos, Frédéric; Zilhão, João

    2011-01-01

    Background The question of whether symbolically mediated behavior is exclusive to modern humans or shared with anatomically archaic populations such as the Neandertals is hotly debated. At the Grotte du Renne, Arcy-sur-Cure, France, the Châtelperronian levels contain Neandertal remains and large numbers of personal ornaments, decorated bone tools and colorants, but it has been suggested that this association reflects intrusion of the symbolic artifacts from the overlying Protoaurignacian and/or of the Neandertal remains from the underlying Mousterian. Methodology/Principal Findings We tested these hypotheses against the horizontal and vertical distributions of the various categories of diagnostic finds and statistically assessed the probability that the Châtelperronian levels are of mixed composition. Our results reject that the associations result from large or small scale, localized or generalized post-depositional displacement, and they imply that incomplete sample decontamination is the parsimonious explanation for the stratigraphic anomalies seen in the radiocarbon dating of the sequence. Conclusions/Significance The symbolic artifacts in the Châtelperronian of the Grotte du Renne are indeed Neandertal material culture. PMID:21738702

  15. Relevamiento total del hemisferio sur celeste en la frecuencia de 1420 MHz

    NASA Astrophysics Data System (ADS)

    Bava, J. A.; Colomb, F. R.; Hurrel, E.; Larrarte, J. J.; Sanz, A. J.; Testori, J. C.; Reich, P.; Reich, W.; Wielebinski, R.

    En el presente artículo se describe el relevamiento del cielo en el Hemisferio Sur Celeste en la frecuencia de 1420 MHz para declinaciones δ<= -19o realizado con la Antena II de 30 metros de diámetro del IAR. Este relevamiento posee igual sensibilidad (3xr.m.s=50 mK) que el realizado en el Hemisferio Norte con el radiotelescopio de 25 metros de Stockert de la Universidad de Bonn, operado por el Max-Planck Institute für Radioastronomie ( Reich W., 1982, A&ASS 48, 219; Reich P. and Reich W., 1986, A&ASS 63, 205). Con los datos obtenidos por ambos radiotelescopios se posee una base de datos de todo el cielo en esta frecuencia. En esta publicación presentamos los detalles del sistema receptor, técnicas de observación y reducción de datos, calibración y discusión de los errores en los resultados.

  16. Isostatic gravity map of the Point Sur 30 x 60 quadrangle and adjacent areas, California

    USGS Publications Warehouse

    Watt, J.T.; Morin, R.L.; Langenheim, V.E.

    2011-01-01

    This isostatic residual gravity map is part of a regional effort to investigate the tectonics and water resources of the central Coast Range. This map serves as a basis for modeling the shape of basins and for determining the location and geometry of faults in the area. Local spatial variations in the Earth's gravity field (after removing variations caused by instrument drift, earth-tides, latitude, elevation, terrain, and deep crustal structure), as expressed by the isostatic anomaly, reflect the distribution of densities in the mid- to upper crust, which in turn can be related to rock type. Steep gradients in the isostatic gravity field often indicate lithologic or structural boundaries. Gravity highs reflect the Mesozoic granitic and Franciscan Complex basement rocks that comprise both the northwest-trending Santa Lucia and Gabilan Ranges, whereas gravity lows in Salinas Valley and the offshore basins reflect the thick accumulations of low-density alluvial and marine sediment. Gravity lows also occur where there are thick deposits of low-density Monterey Formation in the hills southeast of Arroyo Seco (>2 km, Marion, 1986). Within the map area, isostatic residual gravity values range from approximately -60 mGal offshore in the northern part of the Sur basin to approximately 22 mGal in the Santa Lucia Range.

  17. Uranium-series ages of marine terraces, La Paz Peninsula, Baja California Sur, Mexico

    USGS Publications Warehouse

    Sirkin, L.; Szabo, B. J.; Padilla, G.A.; Pedrin, S.A.; Diaz, E.R.

    1990-01-01

    Uranium-series dating of coral samples from raised marine terrace deposits between 1.5 and 10 m above sea level in the La Paz Peninsula area, Baja California Sur, yielded ages between 123 ka and 138 ka that are in agreement with previously reported results. The stratigraphy and ages of marine units near the El Coyote Arroyo indicate the presence of two high stands of the sea during the last interglacial or oxygen isotope substage 5e at about 140 ka and 123 ka. Accepting 5 m for the sea level during the last interglacial transgression, we calculate average uplift rates for the marine terraces of about ???70 mm/ka and 40 mm/ka. These slow rates of uplift indicate a relative stability of the La Paz peninsula area for the past 140 000 years. In contrast, areas of Baja California affected by major faultf experienced higher rates of uplift. Rockwell et al. (1987) reported vertical uplift rates of 180 to 300 mm/ka at Punta Banda within the Aqua Blanea fault zone in northern Baja California. ?? 1990 Springer-Verlag.

  18. Geothermal Exploration Using Remote Sensing in the South of Baja California Sur, Mexico

    NASA Astrophysics Data System (ADS)

    Báncora, Cristina; Prol-Ledesma, Rosa María

    2008-05-01

    The area from Ciudad Constitución to Los Cabos in Baja California Sur was studied using a mosaic of four Landsat ETM+images. The main objective was to define favorable areas for utilization and exploitation of geothermal energy. The approach was to spectrally and spatially enhance the images to define characteristics related with geothermal activity, as are the presence of altered rock and main geological structures. The products of hydrothermal alteration are minerals that belong to two main groups: oxides and hydroxyls. Therefore, image processing is necessary to enhance oxides and hydroxyls spectral features and subdue the vegetation spectral characteristics. The band subtraction (4-3, 3-1, 5-7) gave the finest results due to the fact that it is a linear equation that does not cause loss of information when it is stretched. A color composite was done with these three layers and after a detailed visual analysis three areas were point out to be prospective to contain hydrothermal activity.

  19. Influence of Carbonate Crusts on Trophic Cascades in Big Sur Streams.

    NASA Astrophysics Data System (ADS)

    Rundio, D.; Lindley, S.

    2005-05-01

    Top-down effects of fish predation in streams are influenced by habitat conditions and traits of intermediate consumers. Along the Big Sur coast, seasonal carbonate crusts form in many streams, and appear to alter insect communities. We conducted a small-scale field experiment in two adjacent tributaries (crusted and crust-free) to determine the effects of predation by juvenile steelhead (Oncorhynchus mykiss) on invertebrates and algae in these different stream types. We hypothesized that a trophic cascade would be more likely in the crusted stream, which was dominated by an herbivore vulnerable to steelhead predation (Baetis), than in the crust-free stream, which was dominated by a less vulnerable herbivore (Agapetus). However, excluding steelhead from paving bricks had no effect on algae or Baetis in the crusted stream. Algal abundance was low, suggesting possible bottom-up control. In the crust-free stream, steelhead predation did not affect Agapetus, but nevertheless produced a trophic cascade by causing Baetis to increase by 85%, which in turn depressed algae by 25%. These results suggest that trophic interactions may differ between crust forming and non-crust forming streams, which we plan to test with additional sampling and experiments replicated across stream types.

  20. PDII- Additional discussion of the dynamic aperture

    SciTech Connect

    Norman M. Gelfand

    2002-07-23

    This note is in the nature of an addition to the dynamic aperture calculations found in the report on the Proton Driver, FERMILAB-TM-2169. A extensive discussion of the Proton Driver lattice, as well as the nomenclature used to describe it can be found in TM-2169. Basically the proposed lattice is a racetrack design with the two arcs joined by two long straight sections. The straight sections are dispersion free. Tracking studies were undertaken with the objective of computing the dynamic aperture for the lattice and some of the results have been incorporated into TM-2169. This note is a more extensive report of those calculations.

  1. Clinton plans conference to discuss AIDS epidemic.

    PubMed

    1995-10-20

    President Bill Clinton scheduled the White House Conference on HIV and AIDS in December 1995. The one-day meeting was organized to assemble experts from around the nation to discuss the status of the epidemic and consider strategies to deal with it. The meeting is also intended to raise public awareness to increase prevention. Participants will be divided into working groups to address the status of research, prevention, and care programs; discrimination and legal issues; benefit programs; and coping strategies for those living with HIV and AIDS.

  2. Just a routine operation: a critical discussion.

    PubMed

    McClelland, G; Smith, M B

    2016-05-01

    This article has summarised a critical discussion of the human factors that contributed to the death of a patient from a failure to respond appropriately to a 'can't intubate, can't ventilate' scenario. The contributory factors included the clinical team's inability to communicate, prioritise tasks and demonstrate effective leadership and assertive followership. The film Just a routine operation has now been in circulation for several years. When a system is designed and introduced with the intention of making a change to clinical practice, it can quickly become just another component of an organisation's architecture and complacency around its use can develop. This article has been written specifically for perioperative practitioners to renew the debate around the human factors that contribute to patient harm. By critically discussing Just a routine operation and attempting to review why the incident occurred, this article has attempted to emphasise that some of the conditions and behaviours that contributed to the death of Elaine Bromiley may be latent within our organisations and teams, and may continue to contribute to failures that affect patient safety.

  3. Just a routine operation: a critical discussion.

    PubMed

    McClelland, G; Smith, M B

    2016-05-01

    This article has summarised a critical discussion of the human factors that contributed to the death of a patient from a failure to respond appropriately to a 'can't intubate, can't ventilate' scenario. The contributory factors included the clinical team's inability to communicate, prioritise tasks and demonstrate effective leadership and assertive followership. The film Just a routine operation has now been in circulation for several years. When a system is designed and introduced with the intention of making a change to clinical practice, it can quickly become just another component of an organisation's architecture and complacency around its use can develop. This article has been written specifically for perioperative practitioners to renew the debate around the human factors that contribute to patient harm. By critically discussing Just a routine operation and attempting to review why the incident occurred, this article has attempted to emphasise that some of the conditions and behaviours that contributed to the death of Elaine Bromiley may be latent within our organisations and teams, and may continue to contribute to failures that affect patient safety. PMID:27400489

  4. Accelerating Cleanup: Focus on 2006. Discussion draft

    SciTech Connect

    1997-06-01

    This executive summary addresses the activities associated with the National Transuranic (TRU) Program managed by the Carlsbad Area Office (CAO). The CAO programmatically reports to the Assistant Secretary for Environmental Management and receives administrative support through the Albuquerque Operations Office. The mission of the Carlsbad Area Office (CAO) is to protect human health and the environment by opening and operating the Waste Isolation Pilot Plant for site disposal of TRU waste and by establishing an effective system for management of TRU waste from generation to disposal. It includes personnel assigned to the CAO, the Waste Isolation Pilot Plant (WIPP) site operations, and other activities associated with the National TRU Program. The CAO develops and directs implementation of the program, while the DOE Headquarters establishes policy and guidelines. The CAO assesses compliance with the program guidance, as well as the commonality of activities and assumptions among all the sites. Since the development of the February 28, 1997, database used to develop this Discussion Draft, the opening of the WIPP facility for receipt of Contact Handled waste has been delayed from November 1997 to May 1998. This slippage is significant enough to require a change in the milestones and volumes included in the documents to be reviewed by our stakeholders. Changes have been incorporated into this Discussion Draft and its supporting Project Baseline Summaries (PBSs).

  5. Best Friends’ Discussions of Social Dilemmas

    PubMed Central

    McDonald, Kristina L.; Malti, Tina; Killen, Melanie; Rubin, Kenneth H.

    2013-01-01

    Peer relationships, particularly friendships, have been theorized to contribute to how children and adolescents think about social and moral issues. The current study examined how young adolescent best friends (191 dyads; 53.4% female) reason together about multifaceted social dilemmas and how their reasoning is related to friendship quality. Mutually-recognized friendship dyads were videotaped discussing dilemmas entailing moral, social-conventional and prudential/pragmatic issues. Both dyad members completed a self-report measure of friendship quality. Dyadic data analyses guided by the Actor-Partner Interdependence Model indicated that adolescent and friend's reports of friendship qualities were related to the forms of reasoning used during discussion. Friends who both reported that they could resolve conflicts in a constructive way were more likely to use moral reasoning than friends who reported that their conflict resolution was poor or disagreed on the quality of their conflict resolution. The findings provide evidence for the important role that friendship interaction may play in adolescents’ social and moral development. PMID:23666555

  6. Student decision making in large group discussion

    NASA Astrophysics Data System (ADS)

    Kustusch, Mary Bridget; Ptak, Corey; Sayre, Eleanor C.; Franklin, Scott V.

    2015-04-01

    It is increasingly common in physics classes for students to work together to solve problems and perform laboratory experiments. When students work together, they need to negotiate the roles and decision making within the group. We examine how a large group of students negotiates authority as part of their two week summer College Readiness Program at Rochester Institute of Technology. The program is designed to develop metacognitive skills in first generation and Deaf and hard-of-hearing (DHH) STEM undergraduates through cooperative group work, laboratory experimentation, and explicit reflection exercises. On the first full day of the program, the students collaboratively developed a sign for the word ``metacognition'' for which there is not a sign in American Sign Language. This presentation will focus on three aspects of the ensuing discussion: (1) how the instructor communicated expectations about decision making; (2) how the instructor promoted student-driven decision making rather than instructor-driven policy; and (3) one student's shifts in decision making behavior. We conclude by discussing implications of this research for activity-based physics instruction.

  7. Best friends' discussions of social dilemmas.

    PubMed

    McDonald, Kristina L; Malti, Tina; Killen, Melanie; Rubin, Kenneth H

    2014-02-01

    Peer relationships, particularly friendships, have been theorized to contribute to how children and adolescents think about social and moral issues. The current study examined how young adolescent best friends (191 dyads; 53.4% female) reason together about multifaceted social dilemmas and how their reasoning is related to friendship quality. Mutually-recognized friendship dyads were videotaped discussing dilemmas entailing moral, social-conventional and prudential/pragmatic issues. Both dyad members completed a self-report measure of friendship quality. Dyadic data analyses guided by the Actor-Partner Interdependence Model indicated that adolescent and friend reports of friendship qualities were related to the forms of reasoning used during discussion. Friends who both reported that they could resolve conflicts in a constructive way were more likely to use moral reasoning than friends who reported that their conflict resolution was poor or disagreed on the quality of their conflict resolution. The findings provide evidence for the important role that friendship interaction may play in adolescents' social and moral development.

  8. Values and Commitments Underlying Discussion. Professional Development on Discussion: Group Images in Action.

    ERIC Educational Resources Information Center

    Francis, Eileen

    The Discussion Development Group (DDG) at Moray House College of Education, Scotland, is a resource center designed as an open learning system to provide inservice training, consultancy support, and resources on classroom discussion. A case study involving 17 teachers and recently conducted by the DDG explored features of process innovation and…

  9. Science in Discussions: An Analysis of the Use of Science Content in Socioscientific Discussions

    ERIC Educational Resources Information Center

    Nielsen, Jan Alexis

    2012-01-01

    This paper presents a normative pragmatics analysis of students' use of science content in eight socioscientific group discussions about human gene therapy. The specific focus of the paper is on the argumentative role that invocations of science had in the dialectics of the discussions. The analysis suggests that science content occasionally…

  10. Improving Student Discussions in Graduate and Undergraduate Courses: Transforming the Discussion Leader

    ERIC Educational Resources Information Center

    Soranno, Patricia A.

    2010-01-01

    Student discussions are a common teaching approach in graduate and advanced undergraduate courses because of their benefits to student learning, and to future professional development for natural resources professionals. However, traditional student-led discussions often are ineffective at meeting course and learning objectives and suffer from…

  11. Transgenerational epigenetic inheritance: an open discussion.

    PubMed

    Nagy, Corina; Turecki, Gustavo

    2015-08-01

    Much controversy surrounds the idea of transgenerational epigenetics. Recent papers argue that epigenetic marks acquired through experience are passed to offspring, but as in much of the field of epigenetics, there is lack of precision in the definitions and perhaps too much eagerness to translate animal research to humans. Here, we review operational definitions of transgenerational inheritance and the processes of epigenetic programing during early development. Subsequently, based on this background, we critically examine some recent findings of studies investigating transgenerational inheritance. Finally, we discuss possible mechanisms that may explain transgenerational inheritance, including transmission of an epigenetic blueprint, which may predispose offspring to specific epigenetic patterning. Taken together, we conclude that presently, the evidence suggesting that acquired epigenetic marks are passed to the subsequent generation remains limited.

  12. Transgenerational epigenetic inheritance: an open discussion.

    PubMed

    Nagy, Corina; Turecki, Gustavo

    2015-08-01

    Much controversy surrounds the idea of transgenerational epigenetics. Recent papers argue that epigenetic marks acquired through experience are passed to offspring, but as in much of the field of epigenetics, there is lack of precision in the definitions and perhaps too much eagerness to translate animal research to humans. Here, we review operational definitions of transgenerational inheritance and the processes of epigenetic programing during early development. Subsequently, based on this background, we critically examine some recent findings of studies investigating transgenerational inheritance. Finally, we discuss possible mechanisms that may explain transgenerational inheritance, including transmission of an epigenetic blueprint, which may predispose offspring to specific epigenetic patterning. Taken together, we conclude that presently, the evidence suggesting that acquired epigenetic marks are passed to the subsequent generation remains limited. PMID:26344807

  13. Avoiding the Theory Trap When Discussing Evolution

    NASA Astrophysics Data System (ADS)

    Morrison, David

    2006-02-01

    Public opinion polls tell us that we are losing the battle to explain the nature of evolution and its central role in science. One problem, I believe, is letting the opponents of evolution frame the discussion to our disadvantage. Framing involves the selective use of language or context to trigger responses, either support or opposition. As a prime example, we undercut our communications efforts with many nonscientists by defending the `theory of evolution.' Theory is the wrong word to use in addressing the public. In the contemporary U.S., theory means a hunch or idea that has not been established by evidence. It is thus no surprise that polls show that nearly three quarters of U.S. people think that ``evolution is commonly referred to as the theory of evolution because it has not yet been proven scientifically.'' Those who advocate adding ``only a theory'' disclaimers in textbooks know that to call evolution a theory is sufficient to undermine its acceptance.

  14. Test versus analysis: A discussion of methods

    NASA Technical Reports Server (NTRS)

    Butler, T. G.

    1986-01-01

    Some techniques for comparing structural vibration data determined from test and analysis are discussed. Orthogonality is a general category of one group, correlation is a second, synthesis is a third and matrix improvement is a fourth. Advantages and short-comings of the methods are explored with suggestions as to how they can complement one another. The purpose for comparing vibration data from test and analysis for a given structure is to find out whether each is representing the dynamic properties of the structure in the same way. Specifically, whether: mode shapes are alike; the frequencies of the modes are alike; modes appear in the same frequency sequence; and if they are not alike, how to judge which to believe.

  15. Discussion on ``Teaching the Second Law''

    NASA Astrophysics Data System (ADS)

    Silbey, Robert; Beretta, Gian Paolo; Cengel, Yunus; Foley, Andrew; Gyftopoulos, Elias P.; Hatsopoulos, George N.; Keck, James C.; Lewins, Jeffery; Lior, Noam; Nieuwenhuizen, Theodorus M.; Steinfeld, Jeffrey; von Spakovsky, Michael R.; Wang, Lin-Shu; Zanchini, Enzo

    2008-08-01

    This article reports an open discussion that took place during the Keenan Symposium "Meeting the Entropy Challenge" (held in Cambridge, Massachusetts, on October 5, 2007) following the short presentations—each reported as a separate article in the present volume—by Joseph Smith Jr., Howard Butler, Andrew Foley, Kimberly Hamad-Schifferli, Bernhardt Trout, Jeffery Lewins, Enzo Zanchini, and Michael von Spakovsky. All panelists and the audience were asked to address the following questions • Why is the second law taught in so many different ways? Why so many textbooks on thermodynamics? Why so many schools of thought? • Some say that thermodynamics is limited to equilibrium, others that it extends to nonequilibrium. How is entropy defined for nonequilibrium states?

  16. Middle Ear Adenoma: Case Report and Discussion

    PubMed Central

    Vrugt, B.; Huber, A. M.

    2014-01-01

    Introduction. Despite modern radiological workup, surgeons can still be surprised by intraoperative findings or by the pathologist's report. Materials & Methods. We describe the case of a 52-year-old male who was referred to our clinic with a single sided conductive hearing loss. He ultimately underwent middle ear exploration and excision of a middle ear tumour followed by second look and ossiculoplasty a year later. Results. Though preoperative CT and MRI scanning were suggestive of a congenital cholesteatoma, the pathologist's report diagnosed a middle ear adenoma. Discussion. Middle ear glandular tumors are extremely rare and, despite numerous histological techniques, continue to defy satisfactory classification. Most surgeons advocate surgical excision though evidence of the tumour's natural course and risk of recurrence is lacking. PMID:25045567

  17. Modelisation de la diffusion sur les surfaces metalliques: De l'adatome aux processus de croissance

    NASA Astrophysics Data System (ADS)

    Boisvert, Ghyslain

    Cette these est consacree a l'etude des processus de diffusion en surface dans le but ultime de comprendre, et de modeliser, la croissance d'une couche mince. L'importance de bien mai triser la croissance est primordiale compte tenu de son role dans la miniaturisation des circuits electroniques. Nous etudions ici les surface des metaux nobles et de ceux de la fin de la serie de transition. Dans un premier temps, nous nous interessons a la diffusion d'un simple adatome sur une surface metallique. Nous avons, entre autres, mis en evidence l'apparition d'une correlation entre evenements successifs lorsque la temperature est comparable a la barriere de diffusion, i.e., la diffusion ne peut pas etre associee a une marche aleatoire. Nous proposons un modele phenomenologique simple qui reproduit bien les resultats des simulations. Ces calculs nous ont aussi permis de montrer que la diffusion obeit a la loi de Meyer-Neldel. Cette loi stipule que, pour un processus active, le prefacteur augmente exponentiellement avec la barriere. En plus, ce travail permet de clarifier l'origine physique de cette loi. En comparant les resultats dynamiques aux resultats statiques, on se rend compte que la barriere extraite des calculs dynamiques est essentiellement la meme que celle obtenue par une approche statique, beaucoup plus simple. On peut donc obtenir cette barriere a l'aide de methodes plus precises, i.e., ab initio, comme la theorie de la fonctionnelle de la densite, qui sont aussi malheureusement beaucoup plus lourdes. C'est ce que nous avons fait pour plusieurs systemes metalliques. Nos resultats avec cette derniere approche se comparent tres bien aux resultats experimentaux. Nous nous sommes attardes plus longuement a la surface (111) du platine. Cette surface regorge de particularites interessantes, comme la forme d'equilibre non-hexagonale des i lots et deux sites d'adsorption differents pour l'adatome. De plus, des calculs ab initio precedents n'ont pas reussi a confirmer la

  18. Stratigraphy of Pyroclastic Deposits of EL Aguajito Caldera, Baja California Sur, MÉXICO

    NASA Astrophysics Data System (ADS)

    Osorio Ocampo, L. S.; Macias, J. L.; García Sánchez, L.; Pola, A.; Saucedo, R.; Sánchez, J. M.; Avellán, D. R.; Cardona, S.; Reyes-Agustín, G.; Arce, J. L.

    2015-12-01

    El Aguajito caldera is located in the State of Baja California Sur, it comprises an area of 450 km2 and sits within the Santa Rosalía Basin which is controlled by NE-SW extensional structures and the NW-SE Cimarron Fault that transects the caldera structure. The oldest rocks are ~90 Ma granodiorites covered by an Oligocene-Miocene volcano-sedimentary sequence, the Miocene Santa Lucia Formation and La Esperanza basalt. Pliocene volcanism is represented by La Reforma caldera, El Aguajito caldera, and the Tres Vírgenes Volcanic complex. This study focuses on the cartography and stratigraphy of area in order to understand the evolution of the volcanic system. The stratigraphy from base to top consists of a series of shallow marine sediments (fossiliferous sandstones) covered by a thick sequence of ignimbrites and pyroclastic flows interbedded with volcaniclastic deposits (Gloria and El Infierno Formations). On top of these deposits is El Aguajito caldera, it consists of a 2 m thick pumice fallout followed by an ignimbrite with three transitional lithofacies: a ≤30-m thick light-pink pyroclastic flow enriched in pumice at the base that gradually becomes enrich in lithics towards the top with the occurrence of degasing pipes. On top rests a 15 m-thick light-purple ignimbrite slightly welded with fiammes and a sequence of pumiceous pyroclastic flows and fallouts. These deposits have been associate to the caldera formation with a collapse diameter of ~8 km marked by rhyolitic domes exposed along a ring collapse crowned the sequence as well as NW-SE aligned rhyolitic domes parallel to the seashore. This cartography allowed to present a preliminary new geological map with four stratigraphic units recognized so far, that were emplaced under subaerial conditions beginning with a Plinian column followed by the emplacement of El Aguajito ignimbrite with its subsequent caldera collapse and finally the extrusion of resurgent domes.

  19. L'effet des deformations plastiques severes sur les proprietes d'hydruration du magnesium

    NASA Astrophysics Data System (ADS)

    Lang, Julien

    Le travail de recherche effectue durant mon projet de maitrise en physique a l'Universite du Quebec a Trois-Rivieres dans les laboratoires de l'Institut de Recherche sur l'Hydrogene etait de comparer l'effet du laminage a froid de la poudre de MgH2 avec celui du broyage mecanique. Nous avons etudie cette nouvelle technique en utilisant un laminoir vertical concu specialement pour laminer de la poudre. Nous avons lamine la poudre de MgH2 5, 25, 50 et 100 fois. La comparaison de la morphologie de la poudre de MgH 2 telle que recu du manufacturier et broye mecaniquement pendant 30 minutes avec celle de la poudre laminee ete faite a l'aide d'un microscope electronique a balayage. Nous avons par la suite mesure les proprietes de sorption d'hydrogene grace un appareil PCT de type Sievert. Nous avons aussi determine la structure cristalline par diffraction de rayons X. A partir de ces resultats, nous avons constate que le nombre optimal de laminages est de cinq et a les caracteristiques d'absorption/desorption d'hydrogene similaires a un broyage mecanique de 30 minutes. Nous avons aussi utilise les courbes de cinetiques d'absorption et de desorption d'hydrogene pour calculer l'etape limitative dans les reactions de sorption des echantillons lamines. Comme cinq laminages se font en environ 10 secondes, on voit que le laminage a froid est une technique plus interessante industriellement que le broyage mecanique a cause de l'important gain en temps et en energie.

  20. A discussion of numerical subduction initiation

    NASA Astrophysics Data System (ADS)

    Buiter, Susanne; Ellis, Susan

    2016-04-01

    if subduction can numerically initiate. However, once a setup has been found that successfully initiates subduction, a small change in either rheology or geometry can again lead to subduction initiation failure. We will discuss subduction setups that have been known to fail and how to avoid them, thus potentially leading to successful recipes for numerical subduction initiation. A further point we will discuss is how the geometry of weak zones and pre-existing slabs that are used to initiate a subduction model can impact subsequent subduction style and velocity. For example, using simple linear viscous subduction models we find that initiation along shallow initial pre-existing weak zones and/or pre-existing slabs results in shallow, forward dipping slabs, whereas steep initial dip angles lead to steep slab dips and an overturned slab.

  1. Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse.

    PubMed

    Hong, Seung Hwa; Kyeong, Kyu-Sang; Kim, Chan Hyung; Kim, Young Chul; Choi, Woong; Yoo, Ra Young; Kim, Hun Sik; Park, Yeon Jin; Ji, Il Woon; Jeong, Eun-Hwan; Kim, Hak Soon; Xu, Wen-Xie; Lee, Sang Jin

    2016-08-01

    ATP-sensitive potassium (KATP) channels are well characterized in cardiac, pancreatic and many other muscle cells. In the present study, functional expression of the KATP channel was examined in non-pregnant murine longitudinal myometrium. Isometric contraction measurements and Western blot were used. KATP channel openers (KCOs), such as pinacidil, cromakalim, diazoxide and nicorandil, inhibited spontaneous myometrial contractions in a reversible and glibenclamide-sensitive manner. KCOs inhibited oxytocin (OXT)- and prostaglandin F2α (PGF2α)-induced phasic contractions in a glibenclamide-sensitive manner. SUR2B and Kir6.2 were detected by Western blot, whereas SUR1, SUR2A and Kir6.1 were not. These results show that pinacidl, cromakalim, diazoxide and nicorandil-sensitive KATP channels exist in murine myometrium, which are composed of SUR2B and Kir6.2. Based on the modulatory effects of the KATP channel on spontaneous contraction, OXT- and PGF2α-induced contractions, KATP channels seem to play an essential role in murine myometrial motility via activation of SUR2B and Kir6.2.

  2. Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse

    PubMed Central

    HONG, Seung Hwa; KYEONG, Kyu-Sang; KIM, Chan Hyung; KIM, Young Chul; CHOI, Woong; YOO, Ra Young; KIM, Hun Sik; PARK, Yeon Jin; JI, Il Woon; JEONG, Eun-Hwan; KIM, Hak Soon; XU, Wen-Xie; LEE, Sang Jin

    2016-01-01

    ATP-sensitive potassium (KATP) channels are well characterized in cardiac, pancreatic and many other muscle cells. In the present study, functional expression of the KATP channel was examined in non-pregnant murine longitudinal myometrium. Isometric contraction measurements and Western blot were used. KATP channel openers (KCOs), such as pinacidil, cromakalim, diazoxide and nicorandil, inhibited spontaneous myometrial contractions in a reversible and glibenclamide-sensitive manner. KCOs inhibited oxytocin (OXT)- and prostaglandin F2α (PGF2α)-induced phasic contractions in a glibenclamide-sensitive manner. SUR2B and Kir6.2 were detected by Western blot, whereas SUR1, SUR2A and Kir6.1 were not. These results show that pinacidl, cromakalim, diazoxide and nicorandil-sensitive KATP channels exist in murine myometrium, which are composed of SUR2B and Kir6.2. Based on the modulatory effects of the KATP channel on spontaneous contraction, OXT- and PGF2α-induced contractions, KATP channels seem to play an essential role in murine myometrial motility via activation of SUR2B and Kir6.2. PMID:27086859

  3. Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse.

    PubMed

    Hong, Seung Hwa; Kyeong, Kyu-Sang; Kim, Chan Hyung; Kim, Young Chul; Choi, Woong; Yoo, Ra Young; Kim, Hun Sik; Park, Yeon Jin; Ji, Il Woon; Jeong, Eun-Hwan; Kim, Hak Soon; Xu, Wen-Xie; Lee, Sang Jin

    2016-08-01

    ATP-sensitive potassium (KATP) channels are well characterized in cardiac, pancreatic and many other muscle cells. In the present study, functional expression of the KATP channel was examined in non-pregnant murine longitudinal myometrium. Isometric contraction measurements and Western blot were used. KATP channel openers (KCOs), such as pinacidil, cromakalim, diazoxide and nicorandil, inhibited spontaneous myometrial contractions in a reversible and glibenclamide-sensitive manner. KCOs inhibited oxytocin (OXT)- and prostaglandin F2α (PGF2α)-induced phasic contractions in a glibenclamide-sensitive manner. SUR2B and Kir6.2 were detected by Western blot, whereas SUR1, SUR2A and Kir6.1 were not. These results show that pinacidl, cromakalim, diazoxide and nicorandil-sensitive KATP channels exist in murine myometrium, which are composed of SUR2B and Kir6.2. Based on the modulatory effects of the KATP channel on spontaneous contraction, OXT- and PGF2α-induced contractions, KATP channels seem to play an essential role in murine myometrial motility via activation of SUR2B and Kir6.2. PMID:27086859

  4. [Round table discussion. Ulcer - vagus - gastrin].

    PubMed

    1976-03-01

    1. Both gastrin and the vagus nerve play a part in the pathogenesis of the duodenal ulcer. Which of these two factors is of greater significance--this problem is still subject to discussion as is the question whether other factors such as duodenal neutralization are more important than hitherto assumed. 2. At this time no reliable and harmless drugs that speed up the healing of duodenal ulcers and prevent relapses are yet available. Candidates for this are H2 receptor blockers, prostaglandines and possibly substances resembling secretin. 3. Only some of the participants considered it necessary to do endoscopic and radiological follow-ups in duodenal ulcers. 4. Proximal gastric vagotomy for the treatment of duodenal ulcers is still undergoing clinical trials. At present this method should only be used by surgeons with a special interest in gastric surgery who also dispose of the technology and the staff for careful postoperative checks on these patients. The advantages of proximal gastric vagotomy consist in sparing truncation, low mortality and good functional results. 5. In gastric ulcers--contrary to duodenal ones--malignancy should always be suspected. If medical treatment does not lead to complete remission within a few months, surgery must be performed. 6. Many surgeons still prefer resection to vagotomy and excision in the management of gastric ulcers.

  5. Discussion on ``Foundations of the Second Law''

    NASA Astrophysics Data System (ADS)

    Silbey, Robert; Ao, Ping; Beretta, Gian Paolo; Cengel, Yunus; Foley, Andrew; Freedman, Steven; Graeff, Roderich; Keck, James C.; Lloyd, Seth; Maroney, Owen; Nieuwenhuizen, Theodorus M.; Weissman, Michael

    2008-08-01

    This article reports an open discussion that took place during the Keenan Symposium "Meeting the Entropy Challenge" (held in Cambridge, Massachusetts, on October 4, 2007) following the short presentations—each reported as a separate article in the present volume—by Seth Lloyd, Owen Maroney, Silviu Guiasu, Ping Ao, Jochen Gemmer, Bernard Guy, Gian Paolo Beretta, Speranta Gheorghiu-Svirschevski, and Dorion Sagan. All panelists and the audience were asked to address the following questions • Why is the second law true? Is it an inviolable law of nature? If not, is it possible to develop a perpetual motion machine of the second kind? • Are second law limitations objective or subjective, real or apparent, due to the nature of physical states or the representation and manipulation of information? Is entropy a physical property in the same sense as energy is universally understood to be an intrinsic property of matter? • Does the second law conflict with quantum mechanics? Are the differences between mechanical and thermodynamic descriptions of physical phenomena reconcilable? Does the reversible law of motion of hamiltonian mechanics and quantum mechanics conflict with the empirical observation of irreversible phenomena?

  6. Discussion on ``The Second Law and Energy''

    NASA Astrophysics Data System (ADS)

    Lloyd, Seth; Banerjee, Debjyoti; Bejan, Adrian; Beretta, Gian Paolo; Geskin, Ernest; Ghoniem, Ahmed; Gutowski, Timothy G.; Gyftopoulos, Elias P.; Keck, James C.; Lior, Noam; Miller, Sam; Nieuwenhuizen, Theodorus M.; Peterson, Richard; Salamon, Peter; Williamson, Lihong

    2008-08-01

    This article reports an open discussion that took place during the Keenan Symposium "Meeting the Entropy Challenge" (held in Cambridge, Massachusetts, on October 5, 2007) following the short presentations—each reported as a separate article in the present volume—by Thomas Widmer, Ernest Geskin, James Keck, Noam Lior, Debjyoti Banerjee, Richard Peterson, Erik Ydstie, Ron Zevenhoven, Zhuomin Zhang, and Ahmed Ghoniem. All panelists and the audience were asked to address the following questions • Current state-of-the-art efficiency of combined-cycle energy conversion technology is about 60%. Based on the trend of historical data, some forecast that second-law efficiency of energy conversion will reach 80% by the end of the century. What technologies are at sight that might hold this promise? • Nanotechnologies and microtechnologies point towards the development of microscopic heat engines? How do second law limitations map down to these scales? • Combustion is the principal way of converting the chemical energy of fossil fuels to thermal energy, but it is highly irreversible. Are there promising ways to reduce combustion irreversibility? Are fuel cells the only alternative to combustion?

  7. Indigenous healing practice: ayahuasca. Opening a discussion.

    PubMed

    Prue, Robert; Voss, Richard W

    2014-01-01

    This essay frames an invitation to pastoral counselors and pastoral theologians to examine connections and perhaps interactions between themselves and traditional shamanic healers who use ayahuasca in their healing ceremonies. Indigenous people in South America have used ayahuasca for centuries, and the ritual has become common among the mestizo populations in urban areas of the Amazon, particularly as a curing ritual for drug addiction (Dobkin de Rios, 1970; Moir, 1998). Like peyote in the United States (Calabrese, 1997) ayahuasca use amongst the indigenous people of the Amazon is a form of cultural psychiatry. A review of the literature reveals very little commentary or discussion of shamanic practice in Pastoral Counseling (Pastoral Theology). The scant literature identifies an antithetical relationship at best. The current authors wonder about the possibility of to including shamanic practices in the context of pastoral counseling? This essay seeks to provide some basic information about the ritual use of ayahuasca and to offer a rationale for pastoral counselors to engage in a dialogue about its utility. PMID:25241484

  8. An elementary discussion of propellant flame geometry

    SciTech Connect

    Buckmaster, J.; Jackson, T.L.; Yao, J.

    1999-05-01

    The authors examine the geometry of diffusion flames generated by the burning of a heterogeneous solid propellant, using a simple model designed to provide qualitative insights. In the fast chemistry limit a strategy is used which has its roots in Burke and Schumann`s 1928 study of diffusion flames, albeit with different boundary conditions. This shows that the stoichiometric level surface (SLS) intersects the propellant surface at a point displaced from the fuel/oxidizer interface, and the variations of this displacement with Peclet number are discussed. The authors show that for model sandwich propellants, or their axisymmetric counterpart, the geometry of the SLS when the core is oxidizer is quite different from the geometry of the SLS when the core is fuel. Also, it is much easier to quench the flame on an oxidizer core, by reducing the Peclet number, than it is to quench the flame on a fuel core. When finite chemistry effects are accounted for, the flame only occupies a portion of the SLS, and there is a leading edge structure in which premixing plays a role. Enhancement of the burning rate due to premixing is identified, but a well-defined tribrachial structure is not observed. The authors show how a sharp reduction in pressure can lead to a detachment of the flame from the SLS, with subsequent quenching as it is swept downstream.

  9. Assessing clinical competency: reports from discussion groups.

    PubMed

    Turnwald, Grant; Stone, Elizabeth; Bristol, David; Fuentealba, Carmen; Hardie, Lizette; Hellyer, Peter; Jaeger, Laurie; Kerwin, Sharon; Kochevar, Deborah; Lissemore, Kerry; Olsen, Christopher; Rogers, Kenita; Sabin, Beth; Swanson, Cliff; Warner, Angeline

    2008-01-01

    This report describes proposed new models for assessment of eight of the nine clinical competencies the American Veterinary Medical Association Council on Education requires for accreditation. The models were developed by discussion groups at the Association of American Veterinary Medical Colleges' Clinical Competency Symposium. Clinical competencies and proposed models (in parentheses) are described. Competency 1: comprehensive patient diagnosis (neurologic examination on a dog, clinical reasoning skills); Competency 2: comprehensive treatment planning (concept mapping, computerized case studies); Competency 3: anesthesia, pain management (student portfolio); Competency 4: surgery skills (objective structured clinical examination, cased-based examination, "super dog" model); Competency 5: medicine skills (clinical reasoning and case management, skills checklist); Competency 6: emergency and intensive care case management (computerized case study or scenario); Competency 7: health promotion, disease prevention/biosecurity (360 degrees evaluation, case-based computer simulation); Competency 8: client communications and ethical conduct (Web-based evaluation forms, client survey, communicating with stakeholders, telephone conversation, written scenario-based cases). The report also describes faculty recognition for participating in clinical competency assessments.

  10. Miles Discusses Experiment With NASA Personnel

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Lexington, Massachusetts high school student, Judith Miles, discusses her proposed Skylab experiment with Keith Demorest (right) and Henry Floyd, both of Marshall Space Flight Center (MSFC). In her experiment, called the 'Web Formation in Zero Gravity', called for spiders to be released into a box and their actions recorded to determine how well they adapt to the absence of gravity. Spiders are known to adapt quickly to other changes in the environment but nothing was known of their ability to adapt to weightlessness. At the same time spiders were weaving webs in Earth orbit, similar spiders were spinning webs in identical boxes on Earth under full gravity conditions. Miles was among the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab Mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment.

  11. Miles Discusses Skylab Experiment With NASA Personnel

    NASA Technical Reports Server (NTRS)

    1972-01-01

    Lexington, Massachusetts high school student, Judith Miles, discusses her proposed Skylab experiment with engineers and scientists during a design review of the experiment equipment. At left is Ron Pavlue of Kennedy Space Flight Center (KSC), holding a box is Keith Demorest of Marshall Space Flight Center (MSFC). Right of Miles is Dr. Raymond Gause, also of MSFC, who is Miles' scientific advisor. In her experiment, called the 'Web Formation in Zero Gravity', spiders were released into a box and their actions recorded to determine how well they adapt to the absence of gravity. Spiders are known to adapt quickly to other changes in the environment but nothing was known of their ability to adapt to weightlessness. At the same time spiders were weaving webs in Earth orbit, similar spiders were spinning webs in identical boxes on Earth under full gravity conditions. Miles was among the 25 winners of a contest in which some 3,500 high school students proposed experiments for the following year's Skylab mission. Of the 25 students, 6 did not see their experiments conducted on Skylab because the experiments were not compatible with Skylab hardware and timelines. Of the 19 remaining, 11 experiments required the manufacture of equipment.

  12. Visual adaptation--a reinterpretation: discussion.

    PubMed

    Laming, Donald

    2013-10-01

    This discussion paper seeks to reshape the contemporary understanding of visual adaptation. Received wisdom says that input luminance is scaled down in the retina. There is, first, a near-logarithmic compression described by the Naka-Rushton equation and, second, a control of gain (better attenuation) by feedback from the output of each ganglion cell that is equivalent to modifying the half-saturation constant in the Naka-Rushton equation. The reinterpretation proposed here asserts the following instead: (a) the scaling down in the retina is accomplished by receptive fields of different areas, which function over different ranges of luminance, ranges inversely proportional to the area of the receptive field. (b) The visual pathway is differentially coupled to the physical stimulus, so that the maintained discharge increases only as the square root of the luminance. (c) The Naka-Rushton equation describes merely the saturation of neural response as input increases; when a neuron is overloaded, output tends to regularity and onward transmission is blocked by a subsequent stage of differential coupling. Three existing studies of the relation between input to and output from retinal ganglion cells are reinterpreted in the light of this alternative view of visual adaptation.

  13. Indigenous healing practice: ayahuasca. Opening a discussion.

    PubMed

    Prue, Robert; Voss, Richard W

    2014-01-01

    This essay frames an invitation to pastoral counselors and pastoral theologians to examine connections and perhaps interactions between themselves and traditional shamanic healers who use ayahuasca in their healing ceremonies. Indigenous people in South America have used ayahuasca for centuries, and the ritual has become common among the mestizo populations in urban areas of the Amazon, particularly as a curing ritual for drug addiction (Dobkin de Rios, 1970; Moir, 1998). Like peyote in the United States (Calabrese, 1997) ayahuasca use amongst the indigenous people of the Amazon is a form of cultural psychiatry. A review of the literature reveals very little commentary or discussion of shamanic practice in Pastoral Counseling (Pastoral Theology). The scant literature identifies an antithetical relationship at best. The current authors wonder about the possibility of to including shamanic practices in the context of pastoral counseling? This essay seeks to provide some basic information about the ritual use of ayahuasca and to offer a rationale for pastoral counselors to engage in a dialogue about its utility.

  14. Europe discusses role in future space telescope

    NASA Astrophysics Data System (ADS)

    1998-06-01

    Prof. Roger Bonnet said it was important for Europe to make an informed decision in the next few years on whether to support NASA's proposed New Generation Space Telescope (NGST), a follow-on programme to the Hubble Space Telescope. NGST's observing capabilities will far extend the reach of existing ground or space-based telescopes, providing the opportunity for the first time to look back through eons of time to the very first stars and galaxies in the Universe. With an aperture greater than four metres, NGST could also provide European astronomers with a crucial complement to some of ESA's planned future space projects, like FIRST (the Far InfraRed Submillimetre Telescope) and Planck (a mission to study the cosmic background radiation field). NASA and ESA are already involved in preliminary NGST studies but Europe has yet to make a commitment to support the programme. NASA wants to start formal development in 2003, with a launch currently planned for 2007. This week's conference at Liege in Belgium was the first opportunity for many astronomers to exchange ideas and compare technological notes on a Next Generation Space Telescope. It also provided a forum for representatives of Europe's space industry to discuss the technological challenges presented by such a project. Prof. Bonnet said: "From recent experience it is clear that the best scientific results in astronomy and astrophysics are obtained by coordinated observations in different wavelength ranges. "The joint effort of the European space programme and of the various large European ground observatories currently allows European astronomers to be on the front-line of astrophysics research."He said that ESA - if supported programmatically and financially by its member states - is willing to discuss with NASA a mutually fruitful form of NGST participation. But Prof. Bonnet stressed that for this type of collaboration to be approved it remained crucial that the European share contained both scientific and

  15. Temperature spans for growth: Hypothesis and discussion

    SciTech Connect

    Wiegel, J. )

    1990-01-01

    In recent years the upper and lower temperature limits for growth of pure cultures of microorganisms have been extended at least to 110C and [minus]14C, respectively. There are no organisms which grow at both 0C and 100C and, therefore, organisms are grouped according to their ranges of growth temperatures. Thus, the questions of importance are: (1) What is the widest temperature range (temperature span) over which a single organism can grow and (2) How much can one alter the temperature spans of an organism The concept of cryptic thermophiles' is used to explain some of the published data on the latter question. A wider temperature range can be very important for organisms in various ways, since it makes an organism more versatile with regard to changes in the environment. Also, it enables the organism to utilize a wider range of ecological niches. Some aerobic and anaerobic extreme thermophiles will grow within a span of more than 40C. Furthermore, such organisms are regarded suitable for biotechnological applications as well. The following hypothesis is presented and discussed: these organisms have two sets of key enzymes, and their synthesis is regulated by temperature. Such organisms are capable of growing in two different ranges, such as the mesophilic and thermophilic ranges. The hypothesis is based on the fact that these bacteria exhibit broken Arrhenius plots, and is illustrated with 'temperature tolerant extreme thermophiles' as the major example. However, the hypothesis is not restricted to this group, but it also applicable to the 'temperature tolerant thermophiles and mesophiles'.

  16. Water, food, and population -- a panel discussion.

    PubMed

    1996-01-01

    This paper summarizes a conference panel discussion among parliamentarians and researchers on water and food supplies and population growth in Asia. The Western Samoa legislator urged delegates to be aware of human development that was no more than the promotion of values associated with a market economy. Samoans increased their per capita caloric consumption. The food supply is provided locally, and 90% of exports are food products. Food security would be jeopardized by a fivefold increase in population. Samoan human development indicators were relatively good for a developing country. However, the country was still ranked as a low-income, food-deficit country. The Pakistani delegate explained that Pakistan's agriculture used the largest, continuous irrigation system in the world. However, the system operated inefficiently. There was concern that future high population growth would jeopardize food security. Another barrier was institutional mismanagement of irrigation and reliance on imports for staple items. Agricultural productivity must increase to meet the increased needs of continued population growth. All available land is currently under cultivation. Future strategies will necessitate international cooperation and innovative and environmentally sound technology. Professor Xuan remarked that increased population growth and rising demand, decreased water quality, and changing consumption patterns were a threat to water supplies. Sustainable increases in food production would entail better water management: reforestation to reduce and prevent water runoff, better technological exploitation of rain water, and more efficient use of irrigation systems. Better international financing schemes were needed for support of these policy changes. Professor Ness suggested free markets in water in order to price water at actual rates of consumption. Polluters should pay. Water management was also threatened by global warming.

  17. Impact de la varicocèle sur le volume testiculaire et les paramètres spermatiques

    PubMed Central

    Benazzouz, Mohamed Hicham; Essatara, Younes; El Sayegh, Hachem; Iken, Ali; Benslimane, Lounis; Nouini, Yassine

    2014-01-01

    Introduction La varicocèle est une pathologie masculine fréquente dont l'incidence est encore plus importante dans dans la population des hommes infertiles. Si ses mécanismes sont à ce jour incomplètement expliqués il semble acquis que la varicocèle peut être associée a une dysfonction testiculaire avec diminution du volume testiculaire et de la concentration en spermatozoïde de l’éjaculat. Méthodes Dans un premier temps nous exposons les résultats d'une étude rétrospective sur 5 ans (de Mars 2009 à Mars 2014), réalisée au service d'urologie A de l'hôpital Ibn Sina de Rabat et ayant comme objectif d’évaluer l'impact de la varicocèle palpable sur le volume testiculaire et les paramètres spermatiques. Tous les patients inclus dans notre étude avaient une varicocèle palpable. Dans un deuxième temps, et à travers une revue de la littérature nous discutons l'impact du traitement de la varicocèle sur la fertilité. Résultats 39 patients ont été inclus dans notre étude. L’âge moyen était de 29,71 ans et la varicocèle siégeait dans 89,74% des cas du coté gauche. Une atrophie testiculaire homolatérale à la varicocèle était retrouvée dans 7% des cas alors que des anomalies du spermogramme se voyaient dans 69,23% des cas. Conclusion L'impact de la varicocèle sur l'altération des paramètres spermatiques a été clairement établi bien que sa physio pathogénie ne soit pas bien élucidée. Le traitement chirurgical de la varicocèle semble indiqué chez les hommes infertiles présentant une varicocèle clinique et une altération significative du sperme. PMID:25918574

  18. Current Discussions Between ESO and Chile

    NASA Astrophysics Data System (ADS)

    1995-04-01

    [Joint Press Release by the Government of the Republic of Chile and the European Southern Observatory. The text is issued simultaneously in Santiago de Chile (in Spanish) and at the ESO Headquarters in Garching (in English).] Today, Tuesday, 18 April 1995, at the ESO Headquarters in Garching (Germany), Mr. Roberto Cifuentes, Plenipotentiary Ambassador representing the Government of the Republic of Chile, and the Director General of the European Southern Observatory, Professor Riccardo Giacconi, have signed a Supplementary, Interpretative and Amending Agreement to the Convention of 6 November 1963 which governs the relations between Chile and this International Organisation. This Agreement which in practice signifies a widening and strengthening of the cooperative relations between the Organisation and the Chilean scientific community will hereafter be submitted for ratification by the National Congress of the Republic of Chile (the Parliament) and by the ESO Council. According to the Agreement signed today, Chilean astronomers will have privileged access within up to 10 percent observing time on all present and future ESO telescopes in Chile. Moreover, ESO accepts to incorporate into its labour regulations for Chilean personnel concepts like freedom of association and collective bargaining. This signing of the Supplementary, Interpretative and Amending Agreement to the original Convention of 1963 follows after months of constructive dialogue between the parties. It constitutes an important step towards a solution of some of the pending points on the current agenda for discussions between the Government of Chile and ESO. Among the issues still pending, ESO has informed the Government of Chile that respect for its immunities by the Chilean State is of vital importance for the continuation of the construction of the world's largest telescope at Paranal, as well as the continued presence of the Organisation in Chile. The Chilean Government, on its side, and concerning

  19. Syndrome de Sweet: étude clinique et natomopathologique sur 5 ans

    PubMed Central

    Bouzidi, Hanae; Gallouj, Salim; Amraoui, Nissrine; Mernissi, Fatima Zahra; Harmouch, Taoufiq

    2015-01-01

    Le syndrome de Sweet ou dermatose aiguë fébrile neutrophilique est une maladie inflammatoire rare à expression cutanée prédominante, appartenant au groupe des dermatoses neutrophiliques. Il est caractérisé par le polymorphisme de son expression clinique et la diversité des maladies qui peuvent lui être associées. Le but de ce travail était d’étudier les particularités cliniques, anatomopathologiques, thérapeutiques et évolutives du syndrome de Sweet. Nous rapportons une étude rétrospective et descriptive de 25 cas de syndrome de Sweet observés dans les services de dermatologie et d'anatomie pathologique du centre hospitalier universitaire de Fès sur une période de 5 ans. Notre série était constituée de 5 hommes et de 20 femmes avec un sex-ratio (hommes/femmes) de 0,25. L’âge moyen des patients était de 47 ans avec des extrêmes allant de 11 à 75 ans. Des maladies associées étaient retrouvées chez 17 patients: hémopathies (deux cas), tumeur solide (1cas), maladie chronique de l'intestin (1cas), tuberculose (1 cas), diabète (trois cas) et infections (9 cas). Deux patientes étaient enceintes au moment du diagnostic. Les manifestations cutanées étaient polymorphes avec atteintes muqueuses dans deux cas. Les lésions siégeaient le plus souvent au niveau acral. Histologiquement, le derme était le siège d'un infiltrat dense et diffus riche en polynucléaires neutrophiles dans tous les cas. Une inflammation de la paroi des vaisseaux étaient observées dans trois cas. Le syndrome de Sweet peut être révélateur ou précéder des maladies associées, ce qui impose une surveillance rigoureuse et prolongée. PMID:26185554

  20. Mise à jour sur la vaccination contre l’herpès zoster

    PubMed Central

    Shapiro, Marla; Kvern, Brent; Watson, Peter; Guenther, Lyn; McElhaney, Janet; McGeer, Allison

    2011-01-01

    Résumé Objectif Répondre aux questions fréquentes concernant l’utilisation du nouveau vaccin contre l’herpès zoster (HZ). Sources de l’information Les résultats publiés d’études cliniques et d’autres études, les recommandations du Comité consultatif national de l’immunisation du Canada et de l’Advisory Committee on Immunization Practices des États-Unis; des données ont aussi été obtenues dans la monographie du produit approuvée par Santé Canada sur le vaccin. Principal message L’herpès zoster est causé par la réactivation du virus varicelle-zoster; l’algie post-zostérienne (APZ) est sa complication la plus fréquente et la plus grave. L’incidence de l’APZ après un zona est directement reliée à l’âge, notamment 50 % des personnes affectées de plus de 60 ans qui ont des douleurs persistantes non soulagées. Le vaccin à base de virus vivant contre le HZ réduit l’incidence du zona d’environ 50 % et de 2 tiers l’apparition des APZ. De plus, les symptômes sont atténués et de plus courte durée chez les personnes vaccinées. Le vaccin est contre-indiqué chez de nombreux patients immunodéprimés et pourrait ne pas être efficace chez les patients qui prennent des médicaments antiviraux qui agissent contre le virus HZ. Les médecins devraient être au courant des différentes recommandations touchant ces groupes. Conclusion Le vaccin contre le HZ est une mesure de prévention sécuritaire et efficace pour réduire le fardeau global et la gravité du zona chez les adultes plus âgés. Le vaccin semble rentable lorsqu’il est administré à des adultes de 60 ans et plus.

  1. Le cancer en Mauritanie : résultats sur 10 ans du registre hospitalier de Nouakchott

    PubMed Central

    Baba, Nacer Dine Ould Mohamed; Sauvaget, Catherine

    2013-01-01

    Le fardeau du cancer reste mal connu en Mauritanie. Il n'est basé que sur des extrapolations de l'incidence des cancers des pays avoisinants. Les données du registre de l'hôpital national permettent de décrire les cas avec un diagnostic histologique. Tous les cas de cancers enregistrés par le service d'anatomo-pathologie de l'hôpital national de Nouakchott de 2000 à 2009 ont été analysés. En 10 ans, 3305 prélèvements histologiques ont été analysés (hommes:42%, femmes:58%). Chez l'homme, le cancer le plus fréquemment analysé était le cancer de la peau (218 cas au total, 189 cas en excluant mélanome), suivi de la prostate (203), des cancers digestifs (179, colorectal et ‘sophage), et des lymphomes (151). Chez la femme, un quart des biopsies était des cancers du sein (485), suivi du col utérin (344), de la sphère gynécologique (218, ovaire et corps utérin), et de la peau (114). Les cancers du foie, du poumon ou de la vessie étaient peu fréquents. Ces résultats ne reflètent pas l'incidence ni l'actuel fardeau du cancer en Mauritanie puisque de nombreux patients diagnostiqués avec un cancer ne reçoivent pas d'examen anatomopathologique. Si, comme dans les pays avoisinants du Maroc et du Mali, les cancers du col et du sein sont les pathologies les plus fréquentes chez la femme, la distribution des cancers chez l'homme dans ce registre hospitalier diffère des résultats des registres de population du Maroc et du Mali où les cancers du poumon, du foie, de la prostate et de la vessie dominent. PMID:23785554

  2. Geochemistry of a Tertiary sedimentary phosphate deposit: Baja California Sur, Mexico

    USGS Publications Warehouse

    Piper, D.Z.

    1991-01-01

    The San Gregorio Formation in Baja California Sur, a phosphate-enriched sedimentary unit of late Oligocene to early Miocene age, has been analyzed in two areas (La Purisima and San Hilario) for its chemical composition (major oxides, Cu, Cd, Cr, Co, V, and rare-earth elements - REE) and isotopic composition (??18O and ??13C). A detrital and a marine component were determined from major oxides. The detrital component consists of an unaltered volcanic-ash fraction and a terrigenous clay-silt fraction. The marine component, which accumulated initially as biogenic and hydrogenous material, is now present as opal-A, opal-CT, CaCO3, organic matter, and an authigenic phosphate fraction, mostly pelletal and composed of the carbonate-fluorapatite mineral francolite. The minor elements have been partitioned into these components by assuming a constant composition for the two detrital fractions. The composition of the marine component of minor elements can then be interpreted by assuming that the stoichiometry of the original accumulating organic matter was equal to that of modern plankton. The Cu and Cd contents in the marine component of all rocks require that the seawater-derived fractions of these two metals were supplied to the seafloor solely by organic matter. Enrichments of Cr and V at both sites required an additional marine input. On the basis of their geochemistry in the modern ocean, Cr and V could have precipitated, or been adsorbed, onto settling particles from an O2 minimum zone in which the O2 content was low enough to promote denitrification rather than oxygen respiration. An enrichment of the REE, now within the apatite fraction, resulted from their adsorption onto particulates also in the O2 minimum zone and to the dissolution and alteration of biogenic phases (predominantly silica) within the sediment. Co and Fe2O3 show no enrichment above a detrital contribution. The ??18O-values of apatites from the La Purisima site are heavier than those of apatites

  3. Modelling impacts of offshore wind farms on trophic web: the Courseulles-sur-Mer case study

    NASA Astrophysics Data System (ADS)

    Raoux, Aurore; Pezy, Jean-Philippe; Dauvin, Jean-Claude; Tecchio, samuele; Degraer, Steven; Wilhelmsson, Dan; Niquil, Nathalie

    2016-04-01

    The French government is planning the construction of three offshore wind farms in Normandy. These offshore wind farms will integrate into an ecosystem already subject to a growing number of anthropogenic disturbances such as transportation, fishing, sediment deposit, and sediment extraction. The possible effects of this cumulative stressors on ecosystem functioning are still unknown, but they could impact their resilience, making them susceptible to changes from one stable state to another. Understanding the behaviour of these marine coastal complex systems is essential in order to anticipate potential state changes, and to implement conservation actions in a sustainable manner. Currently, there are no global and integrated studies on the effects of construction and exploitation of offshore wind farms. Moreover, approaches are generally focused on the conservation of some species or groups of species. Here, we develop a holistic and integrated view of ecosystem impacts through the use of trophic webs modelling tools. Trophic models describe the interaction between biological compartments at different trophic levels and are based on the quantification of flow of energy and matter in ecosystems. They allow the application of numerical methods for the characterization of emergent properties of the ecosystem, also called Ecological Network Analysis (ENA). These indices have been proposed as ecosystem health indicators as they have been demonstrated to be sensitive to different impacts on marine ecosystems. We present here in detail the strategy for analysing the potential environmental impacts of the construction of the Courseulles-sur-Mer offshore wind farm (Bay of Seine) such as the reef effect through the use of the Ecopath with Ecosim software. Similar Ecopath simulations will be made in the future on the Le Tréport offshore wind farm site. Results will contribute to a better knowledge of the impacts of the offshore wind farms on ecosystems. They also allow to

  4. Discussing Ethical Issues in the Classroom: Leveraging Pedagogical Moments that May Otherwise Undermine Important Discussions

    ERIC Educational Resources Information Center

    Simpson, Douglas J.; Hull, William J., Jr.

    2011-01-01

    The authors identify, examine, and clarify three kinds of hindrances (dismissive/evasive tactics, logical stoppers, and ad hominem arguments) to teaching about ethical issues in P-12 schools. In discussing these three types of obstacles, they stress that the barriers themselves provide both challenges and opportunities for teachers. Indeed, they…

  5. Une arthrite septique sur prothèse totale de genou à Pasteurella multocida: à propos d'un cas

    PubMed Central

    Kouevidjin, Biova Teko; Bassinga, Jonathan Sylvanus

    2015-01-01

    Une arthrite septique sur PTG est due essentiellement au Staphylococcus aureus suivie des staphylocoques à coagulase négative, et les streptocoques. Au cours de ses 40 dernières années très peu de cas d'infection sur arthroplastie à Pasteurella multocida ont été rapporté. La présentation clinique n'a rien de spécifique.la contamination survient après une morsure, griffure ou léchage d'un chat. L'interrogatoire et l'examen bactériologique est la clé du diagnostique. Nous rapportons le cas d'une patiente de 84 ans qui présente une infection a Pasteurella multocida suite à une morsure du chat 06 jours au paravent. Elle a bénéficié d'une prise en charge chirurgicale par lavage et synovectomie et une bi-antibiothérapie avec bonne évolution. PMID:26523162

  6. Methodologie de conception numerique d'un ventilateur helico-centrifuge basee sur l'emploi du calcul meridien

    NASA Astrophysics Data System (ADS)

    Lallier-Daniels, Dominic

    La conception de ventilateurs est souvent basée sur une méthodologie « essais/erreurs » d'amélioration de géométries existantes ainsi que sur l'expérience de design et les résultats expérimentaux cumulés par les entreprises. Cependant, cette méthodologie peut se révéler coûteuse en cas d'échec; même en cas de succès, des améliorations significatives en performance sont souvent difficiles, voire impossibles à obtenir. Le projet présent propose le développement et la validation d'une méthodologie de conception basée sur l'emploi du calcul méridien pour la conception préliminaire de turbomachines hélico-centrifuges (ou flux-mixte) et l'utilisation du calcul numérique d'écoulement fluides (CFD) pour la conception détaillée. La méthode de calcul méridien à la base du processus de conception proposé est d'abord présentée. Dans un premier temps, le cadre théorique est développé. Le calcul méridien demeurant fondamentalement un processus itératif, le processus de calcul est également présenté, incluant les méthodes numériques de calcul employée pour la résolution des équations fondamentales. Une validation du code méridien écrit dans le cadre du projet de maîtrise face à un algorithme de calcul méridien développé par l'auteur de la méthode ainsi qu'à des résultats de simulation numérique sur un code commercial est également réalisée. La méthodologie de conception de turbomachines développée dans le cadre de l'étude est ensuite présentée sous la forme d'une étude de cas pour un ventilateur hélico-centrifuge basé sur des spécifications fournies par le partenaire industriel Venmar. La méthodologie se divise en trois étapes: le calcul méridien est employé pour le pré-dimensionnement, suivi de simulations 2D de grilles d'aubes pour la conception détaillée des pales et finalement d'une analyse numérique 3D pour la validation et l'optimisation fine de la géométrie. Les résultats de calcul m

  7. Table ronde sur l'evolution de la traduction (Round Table on the Evolution of Translation)

    ERIC Educational Resources Information Center

    Coty, Jean-Paul; And Others

    1975-01-01

    This is a discussion of the future of translation as a profession. The following are discussed: the quantitative growth of translation; the growth of translation as a technical profession; the influence of this growth on the future of translation training; the influence of translation on Canadian French; machine translation; and the future role of…

  8. Listening to Strangers: Classroom Discussion in Democratic Education

    ERIC Educational Resources Information Center

    Parker, Walter C.

    2010-01-01

    Background/Context: The literature on classroom discussion often undercuts itself by treating discussion only as an instructional method, confining its role to the instrumental. Although discussion does serve as an effective means to other curricular ends (teaching with discussion), the capable practice of discussion can also be considered a…

  9. How to engage in a reflective discussion for revalidation.

    PubMed

    2016-09-12

    How to engage in a reflective discussion for revalidation: 'The purpose of the reflective discussion is to encourage a culture of information sharing, reflection and improvement by enabling registrants to discuss their professional development and improvement activities'. PMID:27615588

  10. Stratigraphy and geochronology of the Comondú Group near Loreto, Baja California sur, Mexico

    NASA Astrophysics Data System (ADS)

    Umhoefer, Paul J.; Dorsey, Rebecca J.; Willsey, Shawn; Mayer, Larry; Renne, Paul

    2001-10-01

    Upper Oligocene to Middle Miocene volcanic and sedimentary rocks in the Loreto region, Baja California Sur, are widely exposed and make up the Comondú Group as redefined here following McFall. The Comondú Group is part of a volcanic arc and forearc basin that formed along the northwestern margin of Mexico. Regional to detailed scale mapping, stratigraphic analysis, and geochronology in a 10-20-km-wide and 70-km-long belt from the gulf escarpment to the coast near Loreto reveal three main units in the Comondú Group and a composite thickness of ˜1.5-2 km. (1) The lower clastic unit (˜30-19 Ma) contains 200-300 m of fluvial sandstone and conglomerate with probable local eolian deposits and numerous felsic tuffs and basalt flows that accumulated in a forearc basin. (2) The middle breccia and lava flow unit (˜19-15 Ma) is up to 750 m thick and consists of massive andesite breccia that was deposited as proximal debris flows interbedded with minor andesite lava flows. (3) The upper lava flow and breccia unit (˜15-12 Ma) consists almost entirely of up to ˜600 meters of andesite lava flows a few kilometers west of Loreto that are part of a composite volcano. North and south of Loreto for up to 25 km, the unit is composed of andesite lava flows and massive andesite breccia that formed from thick debris flows near that and other volcanic centers. The three units of the Comondú Group in the Loreto area correlated with the Salto, Pelones, and Ricasón formations of the Bahı´a Concepción area. The lower clastic unit of this study is time equivalent to the marine San Gregorio, El Cien, and Isidro formations on the western and southern Baja California peninsula. The middle and upper units of the Loreto area are the proximal equivalent to the type section of the Comondú Group near the village of Comondú. During deposition of the lower part of the Comondú Group, the arc lay to the east on mainland Mexico in the Sierra Madre Occidental, and then migrated to the

  11. Mesure et retroaction sur un qubit multi-niveaux en electrodynamique quantique en circuit non lineair

    NASA Astrophysics Data System (ADS)

    Boissonneault, Maxime

    L'electrodynamique quantique en circuit est une architecture prometteuse pour le calcul quantique ainsi que pour etudier l'optique quantique. Dans cette architecture, on couple un ou plusieurs qubits supraconducteurs jouant le role d'atomes a un ou plusieurs resonateurs jouant le role de cavites optiques. Dans cette these, j'etudie l'interaction entre un seul qubit supraconducteur et un seul resonateur, en permettant cependant au qubit d'avoir plus de deux niveaux et au resonateur d'avoir une non-linearite Kerr. Je m'interesse particulierement a la lecture de l'etat du qubit et a son amelioration, a la retroaction du processus de mesure sur le qubit de meme qu'a l'etude des proprietes quantiques du resonateur a l'aide du qubit. J'utilise pour ce faire un modele analytique reduit que je developpe a partir de la description complete du systeme en utilisant principalement des transfprmations unitaires et une elimination adiabatique. J'utilise aussi une librairie de calcul numerique maison permettant de simuler efficacement l'evolution du systeme complet. Je compare les predictions du modele analytique reduit et les resultats de simulations numeriques a des resultats experimentaux obtenus par l'equipe de quantronique du CEASaclay. Ces resultats sont ceux d'une spectroscopie d'un qubit supraconducteur couple a un resonateur non lineaire excite. Dans un regime de faible puissance de spectroscopie le modele reduit predit correctement la position et la largeur de la raie. La position de la raie subit les decalages de Lamb et de Stark, et sa largeur est dominee par un dephasage induit par le processus de mesure. Je montre que, pour les parametres typiques de l'electrodynamique quantique en circuit, un accord quantitatif requiert un modele en reponse non lineaire du champ intra-resonateur, tel que celui developpe. Dans un regime de forte puissance de spectroscopie, des bandes laterales apparaissent et sont causees par les fluctuations quantiques du champ electromagnetique

  12. Late Quaternary Faulting along the San Juan de los Planes Fault Zone, Baja California Sur, Mexico

    NASA Astrophysics Data System (ADS)

    Busch, M. M.; Coyan, J. A.; Arrowsmith, J.; Maloney, S. J.; Gutierrez, G.; Umhoefer, P. J.

    2007-12-01

    As a result of continued distributed deformation in the Gulf Extensional Province along an oblique-divergent plate margin, active normal faulting is well manifest in southeastern Baja California. By characterizing normal-fault related deformation along the San Juan de los Planes fault zone (SJPFZ) southwest of La Paz, Baja California Sur we contribute to understanding the patterns and rates of faulting along the southwest gulf-margin fault system. The geometry, history, and rate of faulting provide constraints on the relative significance of gulf-margin deformation as compared to axial system deformation. The SJPFZ is a major north-trending structure in the southern Baja margin along which we focused our field efforts. These investigations included: a detailed strip map of the active fault zone, including delineation of active scarp traces and geomorphic surfaces on the hanging wall and footwall; fault scarp profiles; analysis of bedrock structures to better understand how the pattern and rate of strain varied during the development of this fault zone; and a gravity survey across the San Juan de los Planes basin to determine basin geometry and fault behavior. The map covers a N-S swath from the Gulf of California in the north to San Antonio in the south, an area ~45km long and ~1-4km wide. Bedrock along the SJPFZ varies from Cretaceous Las Cruces Granite in the north to Cretaceous Buena Mujer Tonalite in the south and is scarred by shear zones and brittle faults. The active scarp-forming fault juxtaposes bedrock in the footwall against Late Quaternary sandstone-conglomerate. This ~20m wide zone is highly fractured bedrock infused with carbonate. The northern ~12km of the SJPFZ, trending 200°, preserves discontinuous scarps 1-2km long and 1-3m high in Quaternary units. The scarps are separated by stretches of bedrock embayed by hundreds of meters-wide tongues of Quaternary sandstone-conglomerate, implying low Quaternary slip rate. Further south, ~2 km north of the

  13. Lipid Biomarkers for Methanogens in Hypersaline Cyanobacterial Mats for Guerrero Negro, Baja California Sur

    NASA Technical Reports Server (NTRS)

    Jahnke, Linda L.; Embaye, Tsegereda; Summons, Roger E.; Fonda, Mark (Technical Monitor)

    2002-01-01

    Analyses of sediments from the vicinity of active methane seeps have uncovered a particular suite of lipid biomarker patterns that characterize methane consuming archaea and their syntrophic, sulfate reducing partners. These isoprenoid biomarkers, largely identified by their anomalously light carbon isotopic signatures, have been a topic of intense research activity and are recorded in numerous methane-rich environments from Holocene to Cenozoic. This phenomenon has implications for depleted kerogens at 2.7 Ga on early Earth (Hinrichs 2002). In contrast, the lipid biosignatures of methane producing archaea are not readily identified through distinct isotopic labels and have received comparably little attention in analyses of archaea in environmental samples. Indeed, environmental analyses generally detect only free archaeal lipids, not the intact, polar molecules found in the membrane of living organisms. As part of the Ames NAI, the 'Early Microbial Ecosystem Research Group' (EMERG) is working to understand microbial processes in the hypersaline cyanobacterial mats growing in the salt evaporation ponds of the Exportadora de Sal at Guerrero Negro, Baja California Sur, Mexico. The aim of this study was to develop methods by which we could identify the organisms responsible for methane generation in this environment. While the ester-bound fatty acids, hopanoids and wax esters provide a means to identify most of the bacterial components of these mats, the archaea which Ere evidently present through genomic assays and the fact of intense methane production (Hoehler et al. 200l), have not been identified through their corresponding lipid signatures. Archaeal core lipids present a number of analytical challenges. The core lipids of methanogens comprise C20, C40 and sometimes C25 isoprenoid chains, linked through ether bonds to glycerol. As well as archaeal (C20), sn-2- and sn-3-hydroxyarchaeol are associated particularly with methylotrophic methanogens. Recently, we have

  14. Actes des journees de linguistique: Colloque sur la recherche etudiante (Proceedings of the Linguistics Conference: Colloquium on Student Research) (Quebec, Canada, March 18-19, 1988).

    ERIC Educational Resources Information Center

    Lepage, Danielle, Ed.; Dominik, Annette, Ed.

    Presentations by students at a colloquium on student research on the occasion of the 50th anniversary of the University of Laval's Faculty of Letters, March 18-19, 1988, include: "Une enquete sur la qualite du francais ecrit au Quebec"; "Amenagement linguistique et neologie"; "Analyse syntaxique des 'arrets et retours' en arabe morocain parle";…

  15. Profil bactériologique du pied diabétique et son impact sur le choix des antibiotiques

    PubMed Central

    Zemmouri, Adil; Tarchouli, Mohamed; Benbouha, Abdellatif; Lamkinsi, Tarik; Bensghir, Mustapha; Elouennass, Mostafa; Haimeur, Cherqui

    2015-01-01

    Introduction Analyse du profil bactériologique des pieds diabétiques pris en charge à l'hôpital militaire de Rabat et son influence sur l'antibiothérapie de première intention. Méthodes Etude prospective non randomisée étalée sur 18 mois, ayant concerné 105 patients. Après recueil des données et en attente des résultats bactériologiques nos patients ont été divisés en deux groupes: un groupe a été mis sous Amoxicilline + Acide clavulanique + Gentamycine (59 patients) et un groupe sous Ertapénème±Gentamycine (46 patients). Résultats L’étude a regroupé 85 hommes et 20 femmes (sexe ratio = 4.26). L’âge moyen est de 64.4 ans. La gangrène a été observée chez 79% des malades; elle était humide-donc surinfectée en principe- dans 43% des cas. Par ailleurs, 67% des malades ont un chiffre de globules blancs 12000 définissant une infection sévère. L'ostéolyse a été mise en évidence chez 27% de nos patients. Parmi les différentes techniques de prélèvements: 81% ont été profonds dont 21% de biopsie osseuse per opératoire et 14% de prélèvements combinés. 42% de ces prélèvements sont poly microbiens et 21% sont stériles. Les résultats bactériologiques viennent confirmer la prédominance des bactéries aérobies à Gram positif. Le taux de remplacement de l'Ertapénème est de 22% contre un taux de 50% pour l'Amoxiclav. Conclusion L'antibiothérapie ne doit être instaurée qu'en cas d'infection du pied diabétique diagnostiquée sur les critères cliniques établis par les consensus internationaux récents. Le respect des mesures de lutte contre la diffusion de la résistance bactérienne s'avère primordiale. PMID:27386024

  16. Nicotinamide-rich diet protects the heart against ischaemia-reperfusion in mice: a crucial role for cardiac SUR2A.

    PubMed

    Sukhodub, Andriy; Du, Qingyou; Jovanović, Sofija; Jovanović, Aleksandar

    2010-06-01

    It is a consensus view that a strategy to increase heart resistance to ischaemia-reperfusion is a warranted. Here, based on our previous study, we have hypothesized that a nicotinamide-rich diet could increase myocardial resistance to ischaemia-reperfusion. Therefore, the purpose of this study was to determine whether nicotinamide-rich diet would increase heart resistance to ischaemia-reperfusion and what is the underlying mechanism. Experiments have been done on mice on control and nicotinamide-rich diet (mice were a week on nicotinamide-rich diet) as well as on transgenic mice overexpressing SUR2A (SUR2A mice), a regulatory subunit of cardioprotective ATP-sensitive K(+) (K(ATP)) channels and their littermate controls (WT). The levels of mRNA in heart tissue were measured by real-time RT-PCR, whole heart and single cell resistance to ischaemia-reperfusion and severe hypoxia was measured by TTC staining and laser confocal microscopy, respectively. Nicotinamide-rich diet significantly decreased the size of myocardial infarction induced by ischaemia-reperfusion (from 42.5+/-4.6% of the area at risk zone in mice on control diet to 26.8+/-1.8% in mice on nicotinamide-rich diet, n=6-12, P=0.031). The cardioprotective effect of nicotinamide-rich diet was associated with 11.46+/-1.22 times (n=6) increased mRNA levels of SUR2A in the heart. HMR1098, a selective inhibitor of the sarcolemmal K(ATP) channels opening, abolished cardioprotection afforded by nicotinamide-rich diet. Transgenic mice with a sole increase in SUR2A expression had also increased cardiac resistance to ischaemia-reperfusion. We conclude that nicotinamide-rich diet up-regulate SUR2A and increases heart resistance to ischaemia-reperfusion.

  17. Rupture utérine sur utérus bicorne à 12 semaines d'aménorrhée: à propos d'un cas

    PubMed Central

    Itchimouh, Sanaa; Khabtou, Karima; Mahdaoui, Sakher; Boufettal, Houssine; Samouh, Naima

    2016-01-01

    La fréquence des malformations utérines ayant un impact sur la reproduction est difficile à apprécier. Leur mise en évidence nécessite un bilan spécifique (hystérosalpingographie, hystéroscopie, cœlioscopie). La fertilité spontanée peut être altérée en fonction du type d'anomalie utérine. Toutes ces anomalies peuvent avoir des répercussions sur l’évolution de la conception à type de fausses couches précoces et tardives, de grossesse extra utérine, de menace d'accouchement prématuré, d'accouchement prématuré, de pathologies vasculaires gravidiques et de retard de croissance intra-utérin. L'utérus bicorne est la plus connue des malformations et représente environ la moitié des anomalies de l'utérus. La survenue d'une telle grossesse constitue une situation à risque pouvant entraîner une mort maternelle, mais le diagnostic précoce et un bon suivi peut mener des grossesses à terme sur des utérus malformé. Le dépistage échographique devrait permettre la détection systématique de ce genre de cas afin de prendre préventivement les mesures qui s'imposent. Nous rapportons un cas de rupture utérine sur utérus bicorne unicervical sur grossesse à 12 semaines d'aménorrhée. PMID:27642490

  18. Testosterone protects female embryonic heart H9c2 cells against severe metabolic stress by activating estrogen receptors and up-regulating IES SUR2B.

    PubMed

    Ballantyne, Thomas; Du, Qingyou; Jovanović, Sofija; Neemo, Andrew; Holmes, Robert; Sinha, Sharabh; Jovanović, Aleksandar

    2013-02-01

    A recent clinical study demonstrated that a testosterone supplementation improves functional capacity in elderly female patients suffering from heart failure. These findings prompted us to consider possible mechanisms of testosterone-induced cardioprotection in females. To address this question we have used a pure female population of rat heart embryonic H9c2 cells. Pre-treatment of cells with testosterone for 24h significantly increased survival of H9c2 cells exposed to 2,4-dinitrophenol (DNP), an inhibitor of oxidative phosphorylation. These cells expressed low level of androgen receptors and the effect of testosterone was not modified by hydroxyflutamide, an antagonist of androgen receptor. In contrast, cyclohexamide, an inhibitor of protein biosynthesis, and tamoxifene, a partial agonist of estrogen receptors, abolished cardioprotection afforded by testosterone. In addition, finasteride, an inhibitor of 5α-reductase, and anastrazole, an inhibitor of α-aromatase, also blocked testosterone-induced cytoprotection. Real time RT-PCR revealed that testosterone did not regulate the expression of nine subunits and accessory proteins of sarcolemmal ATP-sensitive K(+) (K(ATP)) channels. On the other hand, testosterone, as well as 17β-estradiol, up-regulated a putative mitochondrial K(ATP) channel subunit, mitochondrial sulfonylurea receptor 2B intraexonics splice variant (IES SUR2B), without affecting expression of IES SUR2A. Tamoxifene inhibited testosterone-induced up-regulation of IES SUR2B without affecting IES SUR2A. In conclusion, this study has shown that testosterone protect female embryonic heart H9c2 cells against severe metabolic stress by its conversion into metabolites that activate estrogen receptors and up-regulate IES SUR2B.

  19. Le défi de la recherche sur les médicaments et du traitement des enfants au Canada

    PubMed Central

    Rieder, Michael J

    2011-01-01

    RÉSUMÉ Les enfants ont toujours été des « orphelins thérapeutiques ». De nombreux médicaments n’ont pas fait l’objet d’études auprès des enfants et des adolescents ou leur utilisation n’est pas autorisée officiellement auprès d’eux, ce qui crée un défi constant en matière d’élaboration et de définition de pharmacothérapies à la sécurité et l’efficacité optimales au sein du groupe d’âge pédiatrique. Depuis dix ans, des réseaux ont germé aux États-Unis et en Europe afin d’accroître la recherche sur les médicaments dans ce groupe, mais aucune évolution comparable ne s’observe au Canada. Le présent document de principes expose le contexte de la situation canadienne et contient des recommandations qui tiennent compte de deux besoins pressants : plus de recherches sur les médicaments axées sur les enfants et les adolescents canadiens, y compris un financement dédié à de telles recherches, et plus d’effectifs pour mener des études ciblées. Ces initiatives devraient être entreprises en collaboration, sur les scènes nationale et internationale, et inclure des démarches stratégiques et novatrices afin de régler les problèmes et enjeux éthiques uniques que présente la recherche sur les médicaments au sein de cette population.

  20. Cancer développé sur dilatation kystique de la voie biliaire: à propos d’un cas

    PubMed Central

    Soufi, Mehdi; Lahlou, Mohammed Khalid; Chad, Bouziane

    2014-01-01

    Les auteurs rapportent un cas de dilatation kystique du cholédoque intra- pancréatique découvert chez une femme de 46 ans et compliqué d'un carcinome tubulo-papillaire n'envahissant pas le pancréas. Le traitement a consisté en une duodénopancréatectomie céphalique avec un curage ganglionnaire et anastomose hépatico-jéjunale; la survie était de 30 mois; les auteurs abordent les aspects radiologiques, anatomopathologiques, thérapeutiques et pronostiques de ces cancers développé sur dilatation kystique de la voie biliaire et discutent la place d'une radiothérapie complémentaire de la chirurgie susceptible d'améliorer la survie. PMID:25922635

  1. Influence du chrome et du niobium sur l'équilibre α-γ dans les aluminiures de titane

    NASA Astrophysics Data System (ADS)

    Daloz, D.; Hazotte, A.; Lacaze, J.; Charpentier, M.

    2004-12-01

    L’influence du chrome et du niobium sur les transformations et équilibres de phases des aluminiures de titane dans le domaine biphasé a/g est étudiée par analyse thermique différentielle, dilatomètrie, et métallographie quantitative après traitements thermiques suivis de trempe. Les compositions et les taux de phases à l’équilibre sont déterminés pour différentes températures du domaine biphasé a/g. Les résultats sont comparés aux calculs thermodynamiques réalisés à l’aide d’une banque de données relative aux intermétalliques de base Ti-Al.

  2. Reconnaissance geologic map of the Loreto and part of the San Janier quadrangles, Baja California Sur, Mexico

    USGS Publications Warehouse

    McLean, Hugh

    1988-01-01

    The Loreto area of Baja California Sur, Mexico, contains a diverse association of igneous, sedimentary, and metasedimentary rocks exposed in the foothills and arroyos between the Sierra La Giganta and Gulf of California. The Loreto area was selected for this study to examine the possible relation of the marine rocks to the opening of the Gulf of California, and to determine the stratigraphic and structural relations between basement rocks composed of granitic and prebatholithic rocks and overlying Tertiary (mainly Miocene) sedimentary and volcanic rocks, and by a sequence of Pliocene marine and nonmarine sedimentary rocks. The Pliocene marine rocks lie in a structural depression informally called here, the Loreto embayment. This geologic map and report stem from a cooperative agreement between the U.S. Geological Survey and the Consejo de Recursos Minerales of Mexico that was initiated in 1982.

  3. Framing Classroom Discussion of Same-Sex Marriage

    ERIC Educational Resources Information Center

    Hand, Michael

    2013-01-01

    Assuming that the issue of same-sex marriage should be discussed in schools, how should the discussion be framed? Michael Hand first distinguishes this question from the related but distinct question of whether discussion on this topic should be steered. He then examines three possible frames for discussion of same-sex marriage: the perfectionist…

  4. Characterizing the Issue: Metaphor and Contemporary Impromptu Discussions of Gender.

    ERIC Educational Resources Information Center

    Preston, C. Thomas, Jr.

    1992-01-01

    Discusses metaphor as a device for effective impromptu speaking. Illustrates how impromptu discussions of the Clarence Thomas versus Anita Hill saga utilized metaphors as perspectives from which to instantaneously organize thought and action or an entire situation. Discusses how to assist students to use metaphor in discussions of contemporary…

  5. Evaluation of a Discussion Forum in an Online Class.

    ERIC Educational Resources Information Center

    Letendre, William

    2002-01-01

    Discusses pharmacy students' dissatisfaction with an online discussion forum based on course evaluations and describes the instructors' redesign of the discussion forum. Reports on the action research project used to evaluate the current discussion forum in the online class and concludes the more learner-centered design has been successful.…

  6. Let's Get Started: Strategies for Initiating Authentic Discussion.

    ERIC Educational Resources Information Center

    Johannessen, Larry R.

    One key issue at the heart of conducting classroom discussions is why teachers are attempting to initiate a discussion and what they can do to initiate effective classroom discussions. This paper considers this issue. The paper first considers two classroom discussions which revolve around a short story, "Only Clowns Passing Through" (Jeanne A.…

  7. Discussing Occupy Wall Street on Twitter: Longitudinal Network Analysis of Equality, Emotion, and Stability of Public Discussion

    PubMed Central

    Wang, Pian-Pian; Zhu, Jonathan J.H.

    2013-01-01

    Abstract To evaluate the quality of public discussion about social movements on Twitter and to understand the structural features and evolution of longitudinal discussion networks, we analyze tweets about the Occupy Wall Street movement posted over the course of 16 days by investigating the relationship between inequality, emotion, and the stability of online discussion. The results reveal that (1) the discussion is highly unequal for both initiating discussions and receiving conversations; (2) the stability of the discussion is much higher for receivers than for initiators; (3) the inequality of online discussions moderates the stability of online discussions; and (4) on an individual level, there is no significant relationship between emotion and political discussion. The implications help evaluate the quality of public discussion, and to understand the relationship between online discussion and social movements. PMID:23656222

  8. Table ronde sur l'enseignement de la traduction (Round Table on the Instruction of Translation)

    ERIC Educational Resources Information Center

    Delisle, Jean; And Others

    1975-01-01

    This is a discussion on how translator training can be improved. Some conclusions are: that professional societies, universities, and industries which employ translators should work together; that the role of the student should increase; and that universities should cooperate in researching and implementing a more rigorous system of instruction.…

  9. Regard critique sur la traduction au Canada (A Critical Look at Translation in Canada)

    ERIC Educational Resources Information Center

    Cardinal, Pierre

    1978-01-01

    A discussion of the history, development and present state of translation, both official and non-official, in Canada. It is shown that translation has become an omnipresent public institution and is at present a linguistic reflection of sociopolitical relations existing between the two linguistic communities. (Text is in French.) (AMH)

  10. Reflexions sur L'Evolution de L'Enseignement de la Biologie en Afrique.

    ERIC Educational Resources Information Center

    Sasson, A.

    1980-01-01

    Reviews the main stages of the evolution of biology teaching in Africa. Discusses the UNESCO pilot project, the teaching aids produced for English- and French-speaking countries of Africa, and the "Teacher's Guide on the Biology of Human Populations" and projects needs for further assistance. (CS)

  11. "Good News" Tune Makes Discussion of "Bad News" Sing.

    ERIC Educational Resources Information Center

    Sneed, Don

    1984-01-01

    Recommends playing Anne Murray's recording of "A Little Good News" to promote discussion about the nature of news and Bobbie Gentry's "Ode to Billy Joe" for discussion on writing news stories about suicides. (CRH)

  12. 29 CFR 780.3 - Exemptions discussed in this part.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... industry are discussed in this part 780. These exemptions differ substantially in their terms, scope, and...) exemption (cotton ginning and sugar processing) discussed in subpart I of this part, and the section...

  13. Responding and Sharing: Techniques for Energizing Classroom Discussions.

    ERIC Educational Resources Information Center

    Green, Timothy D.

    2000-01-01

    Describes seven techniques that can be used as part of classroom discussions (at elementary, secondary, and university levels in a variety of subjects) to get students actively involved in discussing their ideas with fellow students. (SR)

  14. Defense Mechanisms: Discussions and Bibliographies; General or Multiple, and Specific.

    ERIC Educational Resources Information Center

    Pedrini, D. T.; Pedrini, Bonnie C.

    This publication considers some Freudian ego mechanisms. The first discussion and bibliography concerns defense mechanisms, in general or in multiple; after which, the discussions and bibliographies concern specific defense mechanisms: denial; displacement, substitution, sublimation; fixation; identification, introjection, incorporation,…

  15. Classroom Discussion of Suicide: An Intervention Tool for the Teacher.

    ERIC Educational Resources Information Center

    Johnson, Wanda Y.

    1985-01-01

    Teachers can play a significant role in adolescent suicide prevention by encouraging classroom discussion on depression and self-destructive behavior. Effectiveness of suicide prevention programs are discussed. Myths and signs of impending suicide are listed. (DF)

  16. Ondes de surface transverses sur plaques piézoélectriques avec réseaux de bandes metalliques déposés sur les 2 faces

    NASA Astrophysics Data System (ADS)

    Ballandras, S.; Gavignet, E.; Bigler, E.

    1995-09-01

    A theoretical model has been implemented to study surface transverse waves propagating on piezoelectric plates of finite thickness with thin metal strip gratings on both sides. Calculations have been performed for AT-cuts of quartz of thickness varying from 140 to 120 μm. The spatial period of the gratings was fixed to 20 μm (acoustic wavelength equal to 40 μm). The dispersion curve relating the angular frequency to the wavenumber presents more than one stopband as found in the usual analyses on semi-infinite substrates. These multiple high-frequency stopbands allow to design and realize high stability resonators or highly sensitive sensors for gravimetry, accelerometer applications, etc. Un modèle théorique a été mis en œuvre pour l'étude des propriétés des ondes de surface transverses se propageant sur des plaques piézoélectriques d'épaisseur finie avec des réseaux de fines bandes métalliques déposés sur chaque face. Les calculs ont été effectués pour des plaques de quartz voisines de la coupe AT et d'épaisseur variant de 140 à 120 μm. La périodicité des réseaux en regard a été fixée à 20 μm (longueur d'onde acoustique 40 μm). La courbe de dispersion reliant la pulsation au nombre d'ondes présente plusieurs bandes d'arrêt incluant celle habituellement mise en évidence pour un substrat semi-infini. L'existence de ces multiples bandes d'arrêt haute fréquence ouvre de nouvelles perspectives pour la réalisation de résonateurs ultrastables ou de capteurs de très grande sensibilité gravimétrique, accélérométrique, etc.

  17. Parents' Plans to Discuss Sexuality with Their Young Children

    ERIC Educational Resources Information Center

    El-Shaieb, Muna; Wurtele, Sandy K.

    2009-01-01

    Two hundred and fourteen (214) parents of young children (M age = 6.75 years) were surveyed about their plans for sexuality discussions with their children. Parents were asked to indicate when they would first discuss sex education with their children for 15 specific topics, how effective they perceived themselves to be at discussing each topic,…

  18. 29 CFR 2701.6 - Discussion during open meetings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Discussion during open meetings. 2701.6 Section 2701.6... GOVERNMENT IN THE SUNSHINE ACT REGULATIONS § 2701.6 Discussion during open meetings. Deliberations, discussions, comments, statements, or observations made during the course of an open meeting do not...

  19. Critical Thinking in Classroom Discussion of Texts: An Ethnographic Perspective.

    ERIC Educational Resources Information Center

    Miller, Suzanne

    An ethnographic approach is taken to describe the development of student critical thinking in the Pittsburgh Discussion Project, focusing primarily on discussion experiences in three classes (one college-bound 9th-grade class and two mainstream 11th-grade classes) over the school year. Weekly discussions were audiotaped, and interviews were…

  20. 21 CFR 20.104 - Summaries of oral discussions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 1 2012-04-01 2012-04-01 false Summaries of oral discussions. 20.104 Section 20... PUBLIC INFORMATION Availability of Specific Categories of Records § 20.104 Summaries of oral discussions. (a) All written summaries of oral discussions, whether in person or by telephone, with members of...

  1. 21 CFR 20.104 - Summaries of oral discussions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 1 2013-04-01 2013-04-01 false Summaries of oral discussions. 20.104 Section 20... PUBLIC INFORMATION Availability of Specific Categories of Records § 20.104 Summaries of oral discussions. (a) All written summaries of oral discussions, whether in person or by telephone, with members of...

  2. 21 CFR 20.104 - Summaries of oral discussions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 1 2011-04-01 2011-04-01 false Summaries of oral discussions. 20.104 Section 20... PUBLIC INFORMATION Availability of Specific Categories of Records § 20.104 Summaries of oral discussions. (a) All written summaries of oral discussions, whether in person or by telephone, with members of...

  3. 21 CFR 20.104 - Summaries of oral discussions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 1 2014-04-01 2014-04-01 false Summaries of oral discussions. 20.104 Section 20... PUBLIC INFORMATION Availability of Specific Categories of Records § 20.104 Summaries of oral discussions. (a) All written summaries of oral discussions, whether in person or by telephone, with members of...

  4. The Effects of Unstructured Group Discussion on Ethical Judgment

    ERIC Educational Resources Information Center

    Richards, Clinton H.; Alder, G. Stoney

    2014-01-01

    The authors examine the effects of shared information and group discussion on ethical judgment when no structure is imposed on the discussion to encourage ethical considerations. Discussants were asked to identify arguments for and against a variety of business behaviors with ethical implications. A group moderator solicited and recorded arguments…

  5. Competitive Live Discussion: The Effective Use of Nonverbal Cues.

    ERIC Educational Resources Information Center

    Littlefield, Robert S.

    Verbal and nonverbal dimensions of communication are a vital part of competitive group discussion. Specific nonverbal elements that have been found useful in competitive group discussion include environment, proxemics, kinesics, objectics, and chronemics. For example, equalizing arrangements for the discussion in the best area of a room enhances…

  6. A Discussion of Can Reaction Mechanisms Be Proven?

    NASA Astrophysics Data System (ADS)

    Yoon, Tehshik

    2009-05-01

    This review responds to the Commentary article " Can Reaction Mechanisms Be Proven? " and continues the discussion engendered by that piece. JCE will provide an online forum for further discussion of the issue. We hope that both faculty and students will contribute their opinions and ideas to this discussion. See Other Reviewer Comments: Brown Lewis Wade

  7. A Discussion of Can Reaction Mechanisms Be Proven?

    NASA Astrophysics Data System (ADS)

    Brown, Theodore L.

    2009-05-01

    This review responds to the Commentary article " Can Reaction Mechanisms Be Proven? " and continues the discussion engendered by that piece. JCE will provide an online forum for further discussion of the issue. We hope that both faculty and students will contribute their opinions and ideas to this discussion. See Other Reviewer Comments: Lewis Yoon Wade

  8. A Discussion of Can Reaction Mechanisms Be Proven?

    NASA Astrophysics Data System (ADS)

    Lewis, David E.

    2009-05-01

    This review responds to the Commentary article " Can Reaction Mechanisms Be Proven? " and continues the discussion engendered by that piece. JCE will provide an online forum for further discussion of the issue. We hope that both faculty and students will contribute their opinions and ideas to this discussion. See Other Reviewer Comments: Brown Yoon Wade

  9. Engaging Graduate Students in Rich Asynchronous Online Discussions

    ERIC Educational Resources Information Center

    Wuttikietpaiboon, Kanya

    2012-01-01

    Given the importance of online instructional procedures that engage students in rich online discussions and enhance the quantity and the quality of the discussions, the purpose of this study was to investigate how a particular online instructor engaged graduate students in rich asynchronous online discussions, what roles the instructor played to…

  10. Automatic Annotation Method on Learners' Opinions in Case Method Discussion

    ERIC Educational Resources Information Center

    Samejima, Masaki; Hisakane, Daichi; Komoda, Norihisa

    2015-01-01

    Purpose: The purpose of this paper is to annotate an attribute of a problem, a solution or no annotation on learners' opinions automatically for supporting the learners' discussion without a facilitator. The case method aims at discussing problems and solutions in a target case. However, the learners miss discussing some of problems and solutions.…

  11. Required Discussion Web Pages in Psychology Courses and Student Outcomes

    ERIC Educational Resources Information Center

    Pettijohn, Terry F., II; Pettijohn, Terry F.

    2007-01-01

    We conducted 2 studies that investigated student outcomes when using discussion Web pages in psychology classes. In Study 1, we assigned 213 students enrolled in Introduction to Psychology courses to either a mandatory or an optional Web page discussion condition. Students used the discussion Web page significantly more often and performed…

  12. Volvulus gastrique aigu sur éventration diaphragmatique de l'adulte: à propos d'un cas et revue de la littérature

    PubMed Central

    Guèye, Mohamadou Lamine; Touré, Alpha Oumar; Thiam, Ousmane; Seck, Mamadou; Cissé, Mamadou; Kâ, Ousmane; Dieng, Madieng; Touré, Cheikh Tidiane

    2015-01-01

    Le volvulus gastrique aigu sur éventration diaphragmatique est une affection rare et une urgence diagnostique et thérapeutique. Sa présentation clinique est peu spécifique et la tomodensitométrie abdominale permet de confirmer le diagnostic. Nous rapportons le cas d'un patient de 22 ans qui présentaitun syndrome occlusif et une voussure épigastrique. A la radiographie de l'Abdomen Sans Préparation, on notait 2 niveaux hydro-aériques sous la coupole diaphragmatique gauche qui était surélevée. Une dévolvulation et une gastrectomie atypique ont été réalisées devant un volvulus gastrique aigu avec nécrose du fundus mis en évidence à la laparotomie. Les suites opératoires ont été simples. PMID:26161223

  13. Simulating social dilemmas: promoting cooperative behavior through imagined group discussion.

    PubMed

    Meleady, Rose; Hopthrow, Tim; Crisp, Richard J

    2013-05-01

    A robust finding in social dilemmas research is that individual group members are more likely to act cooperatively if they are given the chance to discuss the dilemma with one another. The authors investigated whether imagining a group discussion may represent an effective means of increasing cooperative behavior in the absence of the opportunity for direct negotiation among decision makers. Five experiments, utilizing a range of task variants, tested this hypothesis. Participants engaged in a guided simulation of the progressive steps required to reach a cooperative consensus within a group discussion of a social dilemma. Results support the conclusion that imagined group discussion enables conscious processes that parallel those underlying the direct group discussion and is a strategy that can effectively elicit cooperative behavior. The applied potential of imagined group discussion techniques to encourage more socially responsible behavior is discussed.

  14. Restauration fonctionnelle du rachis : effet du niveau initial de douleur sur les performances des sujets lombalgiques chroniques

    PubMed Central

    Caby, Isabelle; Olivier, N; Mendelek, F; Kheir, R Bou; Vanvelcenaher, J; Pelayo, P

    2014-01-01

    HISTORIQUE : La lombalgie chronique est une douleur lombaire persistante d’origine multifactorielle. Le niveau de douleur initial reste faiblement utilisé pour analyser et comparer les réponses des patients lombalgiques au programme de reconditionnement. OBJECTIFS : Apprécier et évaluer les réponses des sujets lombalgiques chroniques très douloureux à une prise en charge dynamique et intensive. MÉTHODOLOGIE : 144 sujets atteints de lombalgie chronique ont été inclus dans un programme de restauration fonctionnelle du rachis de 5 semaines. Les sujets ont été classés en deux groupes de niveau de douleur: un groupe atteint de douleur sévère (n = 28) et un groupe atteint de douleur légère à modérée (n = 106). L’ensemble des sujets ont bénéficié d’une prise en charge identique comprenant principalement de la kinésithérapie, de l’ergothérapie, du reconditionnement musculaire et cardio-vasculaire ainsi qu’un suivi psychologique. Les paramètres physiques (flexibilité, force musculaire) et psychologiques (qualité de vie) ont été mesurés avant (T0) et après le programme (T5sem). RÉSULTATS : L’ensemble des performances physiques et fonctionnelles des sujets très douloureux sont moins bonnes et le retentissement de la lombalgie sur la qualité de vie, pour ces mêmes sujets, est majoré à T0. Toutes les différences significatives constatées à T0 entre les deux groupes s’effacent à T5sem. CONCLUSIONS : Les sujets lombalgiques chroniques très douloureux répondent favorablement au programme dynamique et intensif. L’intensité douloureuse de la lombalgie n’aurait pas d’effet sur les réponses au programme. La restauration fonctionnelle du rachis apporterait aux sujets la possibilité de mieux gérer leur douleur quel que soit son niveau. PMID:25299476

  15. Effet de l'interaction coulombienne sur la localisation d'Anderson dans le gaz bidimensionnel d'électrons

    NASA Astrophysics Data System (ADS)

    Fleury, G.

    2010-09-01

    Nous étudions l’effet des interactions coulombiennes sur la localisation d’Anderson dans le gaz bidimensionnel d’électrons désordonné. L’objectif est de statuer sur la question de l’existence de métaux à deux dimensions. En l’absence d’interaction, la théorie d’échelle de la localisation prédit qu’un désordre infinitésimal suffit à localiser la fonction d’onde électronique et donc à rendre le système isolant à température nulle (Abrahams et al., 1979). Dans certaines limites extrêmes, les interactions peuvent être prises en compte et l’on aboutit également à un état isolant. Cependant, aucune théorie analytique ne permet de traiter le régime quantique non-perturbatif où désordre et interaction sont intermédiaires. Expérimentalement, il est possible de l’explorer dans des échantillons de haute mobilité et basse densité. Depuis 1994, des comportements métalliques inexpliqués y ont été observés (Kravchenko et al., 1994). Nous avons mis au point une méthode numérique permettant d’étudier le problème couplé de la localisation d’Anderson en présence d’interaction. Cette méthode mêle Monte Carlo quantique à température nulle et théorie d’échelle pour la conductance de Thouless. Nous trouvons que la théorie d’échelle de la localisation est préservée en présence d’interaction et donc que le gaz bidimensionnel, même corrélé, est isolant à température nulle. Nos résultats montrent de plus que les interactions délocalisent le gaz bidimensionnel et que cet effet de délocalisation est accru en présence de dégénérescence de vallées. Ils nous permettent de proposer un mécanisme simple rendant compte des principales caractéristiques des comportements métalliques observés expérimentalement.

  16. Ability of a rapid HIV testing site to attract and test vulnerable populations: a cross-sectional study on Actuel sur Rue.

    PubMed

    Engler, Kim; Rollet, Kathleen; Lessard, David; Thomas, Réjean; Lebouché, Bertrand

    2016-10-01

    Quebec's HIV epidemic persists, particularly among men who have sex with men (MSM) and in Montreal. Increasing access to HIV testing is necessary and community-based rapid testing offers one strategy. This paper examines the clienteles and activities of a rapid HIV testing site in Montreal, the pilot project Actuel sur Rue. Comparative analyses were conducted with 1357 MSM, 147 heterosexual men and 64 women who visited Actuel sur Rue between July 2012 and November 2013 on socio-demographics, health, drug use, sexual practices/infection and HIV testing/prevention. Significant group differences were observed in each category. Actuel sur Rue received 1901 clients, conducted 1417 rapid HIV tests and tested 77 never-tested individuals. Rapid testing produced a high reactive rate (2%). Only 1/28 of those with reactive tests had no previous HIV testing, and 36% had used post-exposure prophylaxis, suggesting missed opportunities for prevention. Findings highlight diverse client vulnerability profiles and the relevance of checkpoints and further prevention efforts.

  17. Ontology-based topic clustering for online discussion data

    NASA Astrophysics Data System (ADS)

    Wang, Yongheng; Cao, Kening; Zhang, Xiaoming

    2013-03-01

    With the rapid development of online communities, mining and extracting quality knowledge from online discussions becomes very important for the industrial and marketing sector, as well as for e-commerce applications and government. Most of the existing techniques model a discussion as a social network of users represented by a user-based graph without considering the content of the discussion. In this paper we propose a new multilayered mode to analysis online discussions. The user-based and message-based representation is combined in this model. A novel frequent concept sets based clustering method is used to cluster the original online discussion network into topic space. Domain ontology is used to improve the clustering accuracy. Parallel methods are also used to make the algorithms scalable to very large data sets. Our experimental study shows that the model and algorithms are effective when analyzing large scale online discussion data.

  18. The APGAR rubric for scoring online discussion boards.

    PubMed

    Phillippi, Julia C; Schorn, Mavis N; Moore-Davis, Tonia

    2015-05-01

    The World Health Organization has called for a dramatic increase in the number of midwives and supports the use of innovative programs to assist students in achieving midwifery competencies. Online discussion boards are excellent educational tools for stimulating in-depth student engagement. However, complex discussions can be difficult to grade without a well-constructed rubric. The 'discussion-board APGAR' provides clear scoring criteria for discussions of midwifery care. The discussion-board APGAR has 5 components: Application, Professionalism, Group work, Analysis, and Rationale and provides scoring criteria for unacceptable, marginal, and proficient performance. The discussion-board APGAR is based on the Core Competencies for Basic Midwifery Practice in the United States (US), consistent with the International Confederation of Midwives Essential Competencies for Basic Midwifery Practice, and can be adjusted to be congruent with other midwifery standards.

  19. Electrical Resistivity Tomographies on the detection of adobe buried archaeological structures in Piramide Sur in Cahuachi (Peru)

    NASA Astrophysics Data System (ADS)

    Capozzoli, L.; Masini, N.; Rizzo, E.; Lasaponara, R.; Orefici, G.

    2012-04-01

    During the last two decades of excavations, adobe pyramids dating back from the 6th century B.C. to the 4th century A.D have been unearthed in the ancient Ceremonial Centre of Cahuachi near Nasca (Peru) by an Italian-Peruvian mission directed by Giuseppe Orefici. One of the archaeological sectors, called sector A, has been almost excavated and restored. To complete sector A only a terraced mound named "Piramide Sur" needs to be excavated. In order to provide useful information on the presence of buried structures and platforms as well on the geological stratigraphy a multi-scale approach based on the integration of satellite remote sensing with geophysical techniques was employed. Such investigations were carried out by the Italian mission ITACA, funded by the Italian Ministry Affairs and composed of researchers of two institutes of CNR (IMAA and IBAM), which provides a scientific support for archaeological research, since 2007. In particular, the subsurface features were investigated by Geoelectrical prospecting, performed by using a georesistivimeter for tomography which observe the resistivity value along sections. Several tomographies were carried out to investigate the shallow and deep structure of the pyramid both along the main flank at Nord and on the top. Finally, the integration of all data acquired by the different remote sensing techniques allowed for spatially characterizing the archaeological features, thus providing important information for the planning of the next archaeological campaign.

  20. Chaetognatha in the Bahía Magdalena lagoon complex, Baja California Sur, México: species composition and assemblages.

    PubMed

    Cota Meza, M S

    2011-07-01

    The chaetognaths from 187 zooplankton samples collected from the Bahia Magdalena lagoon complex, Baja California Sur, Mexico during March, June, July, August, September, November, and December 1982 were studied. Twelve species belonging to two genera were identified. Sagitta euneritica and S. enflata were the most abundant and most frequent species with maximum abundance in July (40,000 org/100 m(3) and 6100 org/100 m(3) respectively). Sagitta pacifica, S. regularis and S. pseudoserratodentata were stenothermic (21 to 25 degrees C), whereas the rest of the species were eurythermic (15.5 to 29.5 degrees C). Sagitta euneritica contributed considerably to the zooplanktonic biomass, increasing the density in particular in BahíaAlmejas. The analysis of the species assemblages (Morisita index) showed that S. pacifica and S. regularis interact more frequently in August when there is a change of the water masses that converge in this zone during summer, when the California Countercurrent predominates. The composition of taxa during winter is characterized by the dominance of S. euneritica. Entering the warm period, an abrupt change occurs in taxa composition of the three zones studied: channels, Bahía Magdalena, and BahíaAlmejas. The amplitude and distribution of S. peruviana was influenced possibility by the oceanographic conditions of ENSO 1982. PMID:22315819

  1. Baseline heavy metals and metalloid values in blood of loggerhead turtles (Caretta caretta) from Baja California Sur, Mexico.

    PubMed

    Ley-Quiñónez, C; Zavala-Norzagaray, A A; Espinosa-Carreón, T L; Peckham, H; Marquez-Herrera, C; Campos-Villegas, L; Aguirre, A A

    2011-09-01

    Environmental pollution due to heavy metals is having an increased impact on marine wildlife accentuated by anthropogenic changes in the planet including overfishing, agricultural runoff and marine emerging infectious diseases. Sea turtles are considered sentinels of ecological health in marine ecosystems. The objective of this study was to determine baseline concentrations of zinc, cadmium, copper, nickel, selenium, manganese, mercury and lead in blood of 22 clinically healthy, loggerhead turtles (Caretta caretta), captured for several reasons in Puerto López Mateos, Baja California Sur, Mexico. Zinc was the most prevalent metal in blood (41.89 μg g⁻¹), followed by Selenium (10.92 μg g⁻¹). The mean concentration of toxic metal Cadmium was 6.12 μg g⁻¹ and 1.01μg g⁻¹ respectively. Mean concentrations of metals followed this pattern: Zn>Se>Ni>Cu>Mn>Cd>Pb and Hg. We can conclude that blood is an excellent tissue to measure in relatively non-invasive way baseline values of heavy metals in Caretta caretta. PMID:21788056

  2. SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson

    PubMed Central

    Santos, Gesivaldo; Giraldez-Alvarez, Lisandro Diego; Ávila-Rodriguez, Marco; Capani, Francisco; Galembeck, Eduardo; Neto, Aristóteles Gôes; Barreto, George E.; Andrade, Bruno

    2016-01-01

    Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested. In addiction to considering the PD as a result of mitochondrial metabolic imbalance and oxidative stress, such as in our previous in vitro model of rotenone, in the present manuscript we added a genomic approach to evaluate the possible underlying mechanisms of the effect of the plant extract. Microarray of substantia nigra (SN) genome obtained from Allen Brain Institute was analyzed using gene set enrichment analysis to build a network of hub genes implicated in PD. Proteins transcribed from hub genes and their ligands selected by search ensemble approach algorithm were subjected to molecular docking studies, as well as 20 ns Molecular Dynamics (MD) using a Molecular Mechanic Poison/Boltzman Surface Area (MMPBSA) protocol. Our results bring a new approach to Valeriana officinalis extract, and suggest that hesperidin, and probably linarin are able to relieve effects of oxidative stress during ATP depletion due to its ability to binding SUR1. In addition, the key role of valerenic acid and apigenin is possibly related to prevent cortical hyperexcitation by inducing neuronal cells from SN to release GABA on brain stem. Thus, under hyperexcitability, oxidative stress, asphyxia and/or ATP depletion, Valeriana officinalis may trigger different mechanisms to provide neuronal cell protection. PMID:27199743

  3. Biological influences on modern sulfates: Textures and composition of gypsum deposits from Guerrero Negro, Baja California Sur, Mexico

    NASA Astrophysics Data System (ADS)

    Vogel, Marilyn B.; Des Marais, David J.; Parenteau, Mary N.; Jahnke, Linda L.; Turk, Kendra A.; Kubo, Michael D. Y.

    2010-01-01

    Gypsum (CaSO 4·2H 2O) deposits from a range of sedimentary environments at Guerrero Negro, Baja California Sur, Mexico were investigated for microscale texture and composition in order to differentiate features formed under substantial microbial influence from those for which microbial effects were relatively minor or absent. Gypsum deposits were classified according to their sedimentary environment, textures, crystal habit, brine composition and other geochemical factors. The environments studied included subaqueous sediments in anchialine pools and in solar salterns, as well as subsurface sediments of mudflats and saltpans. Gypsum that developed in the apparent absence of biofilms included crystals precipitated in the water column and subsedimentary discs that precipitated from phreatic brines. Subsedimentary gypsum developed in sabkha environments exhibited a sinuous microtexture and poikilitically enclosed detrital particles. Water column precipitates had euhedral prismatic habits and extensive penetrative twinning. Gypsum deposits influenced by biofilms included bottom nucleated crusts and gypsolites developing in anchialine pools and saltern ponds. Gypsum precipitating within benthic biofilms, and in biofilms within subaerial sediment surfaces provided compelling evidence of biological influences on crystal textures and habits. This evidence included irregular, high relief surface textures, accessory minerals (S°, Ca-carbonate, Sr/Ca-sulfate and Mg-hydroxide) and distinctive crystal habits such as equant forms and crystals having distorted prism faces.

  4. Syndrome de larva migrans cutanée sur pied malformé (à propos d'un cas)

    PubMed Central

    Benbella, Imane; Khalki, Hanane; Lahmadi, Khalid; Kouara, Sara; Abbadi, Abderrahim; Er-rami, Mohammed

    2016-01-01

    Le syndrome de larva migrans cutanée est une dermite sous cutanée causée par des larves d'ankylostomes d'animaux en impasse parasitaire chez l'homme. L'infestation transcutanée est favorisée par le contact avec le sol contaminé par les larves du parasite. Nous rapportons le cas d'un nourrisson de 15 mois, originaire de Guinée-Bissau, atteint d'un syndrome de larva migrans cutanée sur un pied malformé. Cette malformation sous forme d'une syndactylie associée à une tuméfaction du pied, était à l'origine d'un retard d'acquisition de la station debout. De même, on a rapporté une notion de pieds nus, vue la difficulté de chausser le pied malformé du patient. Tous ces facteurs auraient contribués à favoriser l'infestation du malade par les larves du nématode. PMID:27217876

  5. Rupture utérine spontanée sur léiomyosarcome utérin

    PubMed Central

    Boussouni, Khouloud; Benoulaid, Meryem; Dafiri, Rachida

    2016-01-01

    Les sarcomes utérins sont des cancers rares caractérisés par leur polymorphisme clinique et histologique. Ce sont des tumeurs malignes de mauvais pronostic. Ils se révèlent, généralement, par des symptômes non spécifiques à type de douleurs pelviennes, métrorragies. Un tableau d'abdomen aigu avec hémopneumopéritoine est une présentation rare. Nous rapportons le cas d'un léiomyosarcome utérin qui s'est manifesté par une péritonite aigue généralisée inaugurale chez une femme de 43 ans. Le diagnostic de perforation utérine sur tumeur maligne a été suspecté par l'imagerie préopératoire en urgence (échographie et TDM) et confirmé histologiquement. PMID:27642425

  6. Baseline heavy metals and metalloid values in blood of loggerhead turtles (Caretta caretta) from Baja California Sur, Mexico.

    PubMed

    Ley-Quiñónez, C; Zavala-Norzagaray, A A; Espinosa-Carreón, T L; Peckham, H; Marquez-Herrera, C; Campos-Villegas, L; Aguirre, A A

    2011-09-01

    Environmental pollution due to heavy metals is having an increased impact on marine wildlife accentuated by anthropogenic changes in the planet including overfishing, agricultural runoff and marine emerging infectious diseases. Sea turtles are considered sentinels of ecological health in marine ecosystems. The objective of this study was to determine baseline concentrations of zinc, cadmium, copper, nickel, selenium, manganese, mercury and lead in blood of 22 clinically healthy, loggerhead turtles (Caretta caretta), captured for several reasons in Puerto López Mateos, Baja California Sur, Mexico. Zinc was the most prevalent metal in blood (41.89 μg g⁻¹), followed by Selenium (10.92 μg g⁻¹). The mean concentration of toxic metal Cadmium was 6.12 μg g⁻¹ and 1.01μg g⁻¹ respectively. Mean concentrations of metals followed this pattern: Zn>Se>Ni>Cu>Mn>Cd>Pb and Hg. We can conclude that blood is an excellent tissue to measure in relatively non-invasive way baseline values of heavy metals in Caretta caretta.

  7. Evolution de films de cuivre sur un substrat de cordiérite au cours de traitements thermiques

    NASA Astrophysics Data System (ADS)

    Guille, Jean-Louis; Gondolf, Marc

    1993-04-01

    Copper films were applied on low sintering temperature cordierite substrates either by sputtering or screen printing. Their behaviour during thermal treatments was studied as a function of various parameters : deposition technique, thickness, firing atmosphere, physical state of the substrate (green or sintered). Films were most often broken during the treatment. In the case of screen printed films the effects of an oxydation-reduction cycle of copper are pointed out. Des films de cuivre ont été déposés sur un substrat de cordiérite à basse température de frittage par deux techniques, pulvérisation cathodique et sérigraphie. On étudie leur comportement au cours de traitements thermiques en fonction de différents paramètres : technique de déposition, épaisseur, atmosphère de traitement, état physique du substrat (cru ou fritté). On constate le plus souvent une fragmentation du film. Dans le cas des films sérigraphiés on met en évidence les effets dus à l'oxydation et à la réduction du cuivre.

  8. Panel discussion on the brown dwarf - exoplanet connection

    NASA Astrophysics Data System (ADS)

    Pinfield, D. J.; Beaulieu, J.-P.; Burgasser, A. J.; Delorme, P.; Gizis, J.; Konopacky, Q.

    We present a summary of the panel discussion session on the brown dwarf exoplanet connection, at the Brown Dwarfs Come of Age conference in Fuerteventura. The discussion included an audience vote on the status (planet or brown dwarf) of a selection of interesting objects, as well as a vote on the current components of the IAU definition separating planets and brown dwarfs, and we report the results. In between these two opinion tests we discussed a set of key questions that helped us explore a variety of important areas, and we summarise the resulting discussion both from the panel and the conference audience.

  9. Protein kinase C modulation of recombinant ATP-sensitive K(+) channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B.

    PubMed

    Thorneloe, Kevin S; Maruyama, Yoshiaki; Malcolm, A Todd; Light, Peter E; Walsh, Michael P; Cole, William C

    2002-05-15

    The molecular identity of smooth muscle ATP-sensitive K(+) channels (K(ATP)) is not established with certainty. Patch clamp methods were employed to determine if recombinant K(ATP) channels composed of Kir6.1 and SUR2B subunits expressed by human embryonic kidney (HEK293) cells share an identical modulation by protein kinase C (PKC) with the vascular K(NDP) subtype of K(ATP) channel. The open probability of Kir6.1/SUR2B channels was determined before and after sequential exposure to pinacidil (50 microM) and the combination of pinacidil and phorbol 12,13-dibutyrate (PdBu; 50 nM). Treatment with PdBu caused a decline in channel activity, but this was not seen with an inactive phorbol ester, 4 alpha-phorbol 12,13-didecanoate (PdDe; 50 nM). Angiotensin II (0.1 microM) induced a similar inhibition of Kir6.1/SUR2B channels in cells expressing angiotensin AT(1) receptors. The effects of PdBu and angiotensin II were blocked by the PKC inhibitor, chelerythrine (3 microM). Purified PKC inhibited Kir6.1/SUR2B activity (in 0.5 mM ATP/ 0.5 mM ADP), and the inhibition was blocked by a specific peptide inhibitor of PKC, PKC(19-31). In contrast, PdBu increased the activity of recombinant K(ATP) channels composed of Kir6.2 and SUR2B, or the combination of Kir6.1, Kir6.2 and SUR2B subunits. The results indicate that the modulation by PKC of Kir6.1/SUR2B, but not Kir6.2/SUR2B or Kir6.1-Kir6.2/SUR2B channel gating mimics that of native vascular K(NDP) channels. Physiological inhibition of vascular K(ATP) current by vasoconstrictors which utilize intracellular signalling cascades involving PKC is concluded to involve the modulation of K(NDP) channel complexes composed of four Kir6.1 and their associated SUR2B subunits.

  10. Les effets du travail en equipe dans l'apprentissage par projets sur la motivation des etudiantes et des etudiants en formation des ingenieurs

    NASA Astrophysics Data System (ADS)

    Fernandez, Nicolas

    Les representants des secteurs industriels et les, milieux professionnels en Amerique du Nord reprochaient aux universites de former des ingenieurs avec peu d'experience pratique en resolution de problemes et en conception. Quelques programmes de genie ont alors mis en place le travail en equipe dans l'apprentissage par projets. Beaucoup d'ecrits font valoir les benefices de l'apprentissage par projets sur la motivation des etudiants. Or, ces benefices commencent a peine a faire l'objet de recherches visant a produire des donnees probantes a ce sujet. Les travaux sur la motivation en contexte d'apprentissage et les modeles theoriques developpes sont issus d'environnements d'apprentissage marques par l'enseignement magistral. Le modele de la valeur attendue de la tache (Eccles et Wigfield, 1995; Neuville, 2004) et le modele du systeme-groupe (St-Arnaud, 2008) ont ete retenus pour mesurer les effets du travail en equipe dans l'apprentissage par projets sur la motivation. La recherche visait aussi a approfondir et a nuancer la comprehension de la motivation des etudiants universitaires apprenant en contexte innovant. Les sujets constituent des etudiants (n=100) travaillant sur des projets d'integration au cours des trois sessions initiales du programme de genie mecanique d'une universite canadienne. L'analyse de regression multiple revele que les construits de la motivation expliquent un tiers de la variance de l'engagement academique dans la realisation du projet d'integration. Les perceptions de l' "expectancy", de la valeur intrinseque et utilitaire sont les determinants principaux de l'engagement des etudiants. L'analyse de variance multivariee a mesures repetees indique que la motivation des etudiants pour le travail sur les projets d'integration a augmente au cours des trois sessions initiales du parcours de formation. Finalement, malgre l'absence d'interaction significative entre les variables de motivation et de l'equipe, les reponses des sujets indiquent une

  11. The Socratic Dialogue in Asynchronous Online Discussions: Is Constructivism Redundant?

    ERIC Educational Resources Information Center

    Kingsley, Paul

    2011-01-01

    Purpose: This paper aims to examine Socratic dialogue in asynchronous online discussions in relation to constructivism. The links between theory and practice in teaching are to be discussed whilst tracing the origins of Socratic dialogue and recent trends and use of seminar in research based institutions. Design/methodology/approach: Many online…

  12. Online Forum Discussion Interactions as an Indicator of Student Community

    ERIC Educational Resources Information Center

    Dawson, Shane

    2006-01-01

    Given the current diversity of communication tools at an educator's disposal, what role (if any) does the discussion forum play in the development of a strong sense of community among students? This study sought to investigate the relationship between discussion forum interaction and perceived student sense of community. The results of the study…

  13. Improving the Asynchronous Online Learning Environment Using Discussion Boards

    ERIC Educational Resources Information Center

    Ringler, Ilene; Schubert, Carol; Deem, Jack; Flores, Jimmie; Friestad-Tate, Jill; Lockwood, Robert

    2015-01-01

    Discussion Boards are at the heart of an Asynchronous Online Learning or Distance Education Environment and can have a great impact on the learning experience. Understanding the individual factors that create a high quality discussion board experience for students and their interrelationships is critical to continuous improvement in distance…

  14. Typing the Talk: Electronic Discussions in Short Fiction Classes.

    ERIC Educational Resources Information Center

    Strasma, Kip

    2002-01-01

    Lists several reasons why having students "type their talk" within electronic discussions is important. Presents some practical suggestions of things learned over the years to get students to "type their talk" and enable their words to bring meaning to the electronic discussion of short fiction. (SG)

  15. Teachers' Experiences Relative to Successful Questioning and Discussion Techniques

    ERIC Educational Resources Information Center

    Robitaille, Yvette Powell; Maldonado, Nancy

    2015-01-01

    Questioning and discussion techniques are effective instructional methods, but there is often inconsistent implementation of these instructional methods. This case study explored teachers and evaluators' perceptions regarding exemplary questioning and discussion techniques. Participants included 9 teachers who earned exemplary marks on their…

  16. 14 CFR § 1203.200 - Background and discussion.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Background and discussion. § 1203.200 Section § 1203.200 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION INFORMATION SECURITY PROGRAM NASA Information Security Program § 1203.200 Background and discussion. (a)...

  17. From Socrates to Wikis: Using Online Forums to Deepen Discussions

    ERIC Educational Resources Information Center

    Koopman, Beverly Logas

    2011-01-01

    The author, an elementary teacher, used an online message board and wikis to engage students in literature discussions and to deepen their understanding of and interest in the books they were reading. Her students were much more motivated to read and discuss books using the online tools.

  18. Motivating a Productive Discussion of Normative Issues through Debates

    ERIC Educational Resources Information Center

    Hennessey, Jessica

    2014-01-01

    In this article, the author presents a way of using in-class debates to discuss contentious issues and help students develop critical thinking skills. Three elements were incorporated into an undergraduate public finance course: a presentation of ethical approaches in order to formally discuss normative issues, class debates which required…

  19. Reporting and Discussing Effect Size: Still the Road Less Traveled?

    ERIC Educational Resources Information Center

    McMillan, James H.; Foley, Jennifer

    2011-01-01

    This study shows the extent to which effect size is reported and discussed in four major journals. A series of judgments about different aspects of effect size were conducted for 417 articles from four journals. Results suggest that while the reporting of simple effect size indices is more prevalent, substantive discussions of the meaning of…

  20. The Challenge of Moving beyond the Literal in Literature Discussions

    ERIC Educational Resources Information Center

    Serafini, Frank; Ladd, Sophie M.

    2008-01-01

    Drawing on data associated with an investigation of classroom read alouds and discussions of children's literature, this article conceptualizes the reading aloud and discussions of picturebooks as an "interpretive space" for elementary grade students' exploration of visual images and written text. Analyzing the types of responses…

  1. Increasing Student Participation in Online Group Discussions via Facebook

    ERIC Educational Resources Information Center

    Miller, Scott T.

    2013-01-01

    A comparison study between two different methods of conducting online discussions in an introductory astronomy course was performed to determine if the use of Facebook as an online discussion tool has an impact on student participation as well as student response time. This study shows that students using Facebook for their online discussions…

  2. Group Discussion and Individual Critical Thinking Processes: An Interactive Perspective.

    ERIC Educational Resources Information Center

    Dixson, Marcia D.

    This paper offers a small group discussion model as a viable alternative for facilitating critical thinking. The paper first review literature discussing what critical thinking is and whether it can be taught. After defining critical thinking as an active process which involves constructing arguments, the paper concludes that an optimally…

  3. Increasing Educational Efficiency Through Technology (Commission Discussion and Background Materials).

    ERIC Educational Resources Information Center

    Indiana State Commission for Higher Education, Indianapolis.

    A program schedule and background information for Indiana Commission for Higher Education-sponsored discussion of the use of educational technology to increase educational effeciency are presented. The four major topics of discussion to illustrate the uses and advantages/disadvantages of audio, video, and computing technologies are as follows:…

  4. Using Discussion Pedagogy to Enhance Oral and Written Communication Skills

    ERIC Educational Resources Information Center

    Dallimore, Elise J.; Hertenstein, Julie H.; Platt, Marjorie B.

    2008-01-01

    This research project examines students' reactions to in-class discussion as an instructional technique by investigating the effect of participation practices on communication-based skill development. The findings provide evidence that active preparation and participation in class discussion can be linked to students' reports of improved oral and…

  5. Opening the World of Mathematics: The Daily Math Discussion

    ERIC Educational Resources Information Center

    Donoahue, Zoe

    2016-01-01

    During the author's everyday math discussions with her class, young children talk about mathematical ideas, theories, and concepts within a predictable structure. These discussions include many concepts from--and beyond--the first-grade math curriculum, and their depth and complexity build throughout the school year. Concepts and skills include…

  6. 19 CFR 177.4 - Oral discussion of issues.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Oral discussion of issues. 177.4 Section 177.4... TREASURY (CONTINUED) ADMINISTRATIVE RULINGS General Ruling Procedure § 177.4 Oral discussion of issues. (a... in the Customs Service file in the matter a written record setting forth any and all...

  7. 19 CFR 177.4 - Oral discussion of issues.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Oral discussion of issues. 177.4 Section 177.4... TREASURY (CONTINUED) ADMINISTRATIVE RULINGS General Ruling Procedure § 177.4 Oral discussion of issues. (a... in the Customs Service file in the matter a written record setting forth any and all...

  8. 19 CFR 177.4 - Oral discussion of issues.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Oral discussion of issues. 177.4 Section 177.4... TREASURY (CONTINUED) ADMINISTRATIVE RULINGS General Ruling Procedure § 177.4 Oral discussion of issues. (a... in the Customs Service file in the matter a written record setting forth any and all...

  9. 19 CFR 177.4 - Oral discussion of issues.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Oral discussion of issues. 177.4 Section 177.4... TREASURY (CONTINUED) ADMINISTRATIVE RULINGS General Ruling Procedure § 177.4 Oral discussion of issues. (a... in the Customs Service file in the matter a written record setting forth any and all...

  10. Perspective-Taking in Structured and Unstructured Online Discussions

    ERIC Educational Resources Information Center

    Chadwick, Scott; Ralston, Ekaterina

    2010-01-01

    This study analyzes the extent to which students using web-based discussion boards show an increase in perspective-taking in structured and unstructured discussions. Messages from fifty-six students enrolled in one of two courses were content analyzed using Jarvela and Hakkinen's (2003) expansion of Selman's (1980) perspective-taking coding…

  11. Student Moderators in Asynchronous Online Discussion: A Question of Questions

    ERIC Educational Resources Information Center

    Zingaro, Daniel

    2012-01-01

    Much current research exalts the benefits of having students facilitate weekly discussions in asynchronous online courses. This study seeks to add to what is known about student moderation through an analysis of the types of questions students use to spur each discussion. Prior experimental work has demonstrated that the types of questions posed…

  12. Workforce Intermediation for Vulnerable Youth: Workforce Initiatives Discussion Paper #4

    ERIC Educational Resources Information Center

    Academy for Educational Development, 2011

    2011-01-01

    This paper's intention is to spur discussion about the roles of "workforce intermediation" as it relates to youth development and employability. It is certainly not meant to be an exhaustive discussion about either topic. It does, however, intend to further the dialogue on international workforce initiatives and the requisite workforce…

  13. Permeable Textual Discussion in Tracked Language Arts Classrooms

    ERIC Educational Resources Information Center

    Gritter, Kristine

    2012-01-01

    Permeable textual discussion occurs when the unofficial texts and discursive practices and personal histories that are already recognized and valued in students' cultures are scaffolds to academically sanctioned literacies. Ideally, permeable textual discussions are safe havens where students' identities (racial, gender, world views) are…

  14. How to Create Successful Discussions in Science Classrooms

    ERIC Educational Resources Information Center

    Grover, Neena

    2007-01-01

    Professors often expect students to have the skills that are necessary to participate in discussions. Students, on the other hand, have been trained to glean information from the lecture format; their prior experiences in discussions are likely to be limited to personal opinions on topics such as stem-cell research or evolution. Sudden changes in…

  15. Writing Teaching and the Word Processor. A Computer Discussion Paper.

    ERIC Educational Resources Information Center

    Walshe, R. D., Ed.

    Designed for use by elementary school teachers, this discussion paper discusses the use of the word processor in the teaching of writing. The paper examines both the positive and negative aspects of computer use. After comparing the writing process with the problem solving process, the newsletter provides articles relating teachers' experiences…

  16. Fine-Tuning the Craft of Teaching by Discussion

    ERIC Educational Resources Information Center

    Huang, Li-Shih

    2005-01-01

    Extensive research in cognitive psychology and education shows that discussion facilitates "depth of processing" (Craik & Lockhart, 1972), which in turn promotes thinking, understanding, and retaining information. It is also well recognized that an effectively facilitated discussion is one of the most valuable vehicles for learning. In MBA…

  17. Discussion Strategies for the Inclusion of ALL Students

    ERIC Educational Resources Information Center

    Weih, Timothy G.

    2015-01-01

    Student-centered discussion strategies are described in this article in pursuance of insuring that ALL student voices have a chance to be heard in the classroom. Discussion strategies that are presented include the following: The 10 Second Rule, Think-Pair-Share, Quick Writes, Recorder-Reporter, and K-W-L.

  18. Reconceptualising Moderation in Asynchronous Online Discussions Using Grounded Theory

    ERIC Educational Resources Information Center

    Vlachopoulos, Panos; Cowan, John

    2010-01-01

    This article reports a grounded theory study of the moderation of asynchronous online discussions, to explore the processes by which tutors in higher education decide when and how to moderate. It aims to construct a theory of e-moderation based on some key factors which appear to influence e-moderation. It discusses previous research on the…

  19. Enabling Easier Information Access in Online Discussion Forums

    ERIC Educational Resources Information Center

    Bhatia, Sumit

    2013-01-01

    Online discussion forums have become popular in recent times. They provide a platform for people from different parts of the world sharing a common interest to come together and topics of mutual interest and seek solutions to their problems. There are hundreds of thousands of internet forums containing tens of millions of discussion threads and…

  20. 49 CFR 1111.10 - Meeting to discuss procedural matters.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 8 2011-10-01 2011-10-01 false Meeting to discuss procedural matters. 1111.10... those challenging the reasonableness of a rail rate based on stand-alone cost or the simplified standards, the parties shall meet, or discuss by telephone, discovery and procedural matters within 12...

  1. 49 CFR 1111.10 - Meeting to discuss procedural matters.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 8 2013-10-01 2013-10-01 false Meeting to discuss procedural matters. 1111.10... those challenging the reasonableness of a rail rate based on stand-alone cost or the simplified standards, the parties shall meet, or discuss by telephone, discovery and procedural matters within 12...

  2. 49 CFR 1111.10 - Meeting to discuss procedural matters.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 8 2012-10-01 2012-10-01 false Meeting to discuss procedural matters. 1111.10... those challenging the reasonableness of a rail rate based on stand-alone cost or the simplified standards, the parties shall meet, or discuss by telephone, discovery and procedural matters within 12...

  3. 49 CFR 1111.10 - Meeting to discuss procedural matters.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 8 2014-10-01 2014-10-01 false Meeting to discuss procedural matters. 1111.10... those challenging the reasonableness of a rail rate based on stand-alone cost or the simplified standards, the parties shall meet, or discuss by telephone, discovery and procedural matters within 12...

  4. The Quality of Online Discussion Reported by Graduate Students

    ERIC Educational Resources Information Center

    Du, Jianxia; Xu, Jianzhong

    2010-01-01

    This study examined online group discussion from students' perspectives to determine what characteristics students identify as meaningful to their online learning. Participants were 142 graduate students in the Southeast. The multiple regression results revealed that quality of online discussion was positively associated with communication media,…

  5. Supporting the Participation of English Language Learners in Mathematical Discussions.

    ERIC Educational Resources Information Center

    Moschkovich, Judit

    1999-01-01

    Explores how teachers can support English-language learners in learning mathematics. Uses discourse perspective to analyze participation in mathematical discussions. Examines a lesson from a third-grade mathematics discussion of the geometric shapes of a tangram puzzle. Contains 20 references. (ASK)

  6. Education for Judgment: The Artistry of Discussion Leadership.

    ERIC Educational Resources Information Center

    Christensen, C. Roland, Ed.; And Others

    This book offers a collection of essays on teaching, written by teachers who, though they represent high school to professional school levels and diverse fields of interest, favor teaching by discussion. Part I introduces key principles in "Barriers and Gateways to Learning" (David A. Garvin) and "Premises and Practices of Discussion Teaching" (C.…

  7. Language-Rich Discussions for English Language Learners

    ERIC Educational Resources Information Center

    Zhang, Jie; Anderson, Richard C.; Nguyen-Jahiel, Kim

    2013-01-01

    A study involving 75 Spanish-speaking fifth graders from a school in the Chicago area investigated whether a peer-led, open-format discussion approach, known as Collaborative Reasoning, would accelerate the students' English language development. Results showed that, after participating in eight discussions over a four-week period, the CR group…

  8. Increasing Social Presence in Online Learning through Small Group Discussions

    ERIC Educational Resources Information Center

    Akcaoglu, Mete; Lee, Eunbae

    2016-01-01

    Social presence is difficult to achieve, but an imperative component of online learning. In this study, we investigated the effect of group size on students' perceptions of social presence in two graduate-level online courses, comparing small group versus whole class discussions. Our results indicated that when in small group discussions, students…

  9. Face to Face: U.S.-Soviet Summitry. Discussion Guide.

    ERIC Educational Resources Information Center

    Weinstein, Allen, Ed.

    This document is the discussion guide for a four part video/print series designed to contribute to the understanding of the U.S.-Soviet relationship and the summitry process which has become such a visible part of it. Each of the four 30-minute programs interweaves archival material with informal discussions by distinguished scholars about…

  10. Discontinuities in University Student Experiences of Learning through Discussions

    ERIC Educational Resources Information Center

    Ellis, Robert A.; Calvo, Rafael A.

    2006-01-01

    This article reports on research into the student experience of learning through discussions in a third-year undergraduate engineering subject. Information engineering students studying e-commerce were required to engage in face-to-face and online discussions as a key aspect of their learning experience. This study investigates the quality of the…

  11. Analysis of Asynchronous Online Discussion Using the SOLO Taxonomy

    ERIC Educational Resources Information Center

    Holmes, Kathryn

    2005-01-01

    The online learning environment provides the opportunity for remote groups of students to interact with instructors and each other. Most web based learning platforms facilitate synchronous online discussions between participants. These discussion forums are designed to replicate the face to face tutorial setting and provide a medium for the…

  12. Panel Discussion on Obstacles to Entering the Teaching Profession

    ERIC Educational Resources Information Center

    Brookings Papers on Education Policy, 2004

    2004-01-01

    The first day's session of the 2003 Brookings conference on education concluded with a roundtable discussion of the obstacles to recruiting new teachers into the profession, especially for urban schools. The discussion, moderated by Diane Ravitch, began with informal presentations by two people who have been deeply involved in addressing this…

  13. English Proficiency and Participation in Online Discussion for Learning

    ERIC Educational Resources Information Center

    Leung, Steve

    2013-01-01

    Does English proficiency affect participation in online discussion? This study polled 14 students from a postgraduate online course that require online discussion. The students are divided into groups according to their home language spoken and self-assessed English proficiency, and measure against their participation level in the required…

  14. Classroom Discussions: Seeing Math Discourse in Action, Grades K-6

    ERIC Educational Resources Information Center

    Anderson, Nancy; Chapin, Suzanne; O'Connor, Cathy

    2011-01-01

    "Classroom Discussions: Seeing Math Discourse in Action, Grades K-6" provides preservice and inservice instructors, coaches and facilitators with real, classroom-based video examples that illustrate the principles and practices covered in the authors' best-selling book, "Classroom Discussions: Using Math Talk to Help Students Learn, Grade K-6,…

  15. Helping Mothers Discuss Sexuality and AIDS with Adolescents.

    ERIC Educational Resources Information Center

    Lefkowitz, Eva S.; Sigman, Marian; Au, Terry Kit-fong

    2000-01-01

    Examined impact of experimentally altering mothers' style when discussing sexuality and AIDS with adolescent children. Found that intervention group mothers reduced their amount of speaking, asked more open-ended questions, acted less judgmental, and discussed dating and sexuality more than did control group mothers. Intervention group adolescents…

  16. 40 CFR 158.340 - Discussion of formation of impurities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... require an expanded discussion of information on impurities: (1) From other possible chemical reactions... why they may be present. The discussion should be based on established chemical theory and on what the... range of levels) of these impurities. (iii) The intended reactions and side reactions which may occur...

  17. Anchoring Students' Metaperspective Discussions of History in Mathematics

    ERIC Educational Resources Information Center

    Jankvist, Uffe Thomas

    2011-01-01

    The article discusses an empirical study on the use of history (as a goal) in mathematics education. A historical module was designed and implemented in a Danish upper secondary class to study how students' discussions of metaperspective issues of the historical development of mathematics may be anchored in the taught and learned subject matter of…

  18. Bullying, Intimidation and Harassment Prevention School Policy. A Discussion Paper

    ERIC Educational Resources Information Center

    Montana Office of Public Instruction, 2005

    2005-01-01

    This paper provides a background and discussion regarding the need for school policy and procedures to prevent bullying, intimidation and harassment in schools. The paper is intended to focus discussion on the responsibility of school boards, administrators and staff in making the school environment a safe place for all students. In so doing,…

  19. Facilitating Meaningful Discussion Groups in the Primary Grades

    ERIC Educational Resources Information Center

    Moses, Lindsey; Ogden, Meridith; Kelly, Laura Beth

    2015-01-01

    This Teaching Tips describes a yearlong process of facilitating meaningful discussion groups about literature with first-grade students in an urban Title I school. At the beginning of the year, the teacher provided explicit instruction in speaking and listening skills to support students with the social skills needed for thoughtful discussion. She…

  20. 19 CFR 181.95 - Oral discussion of issues.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Oral discussion of issues. 181.95 Section 181.95... of issues. (a) General. A person submitting a request for an advance ruling and desiring an opportunity to orally discuss the issue or issues involved should indicate that desire in writing at the...

  1. 19 CFR 177.4 - Oral discussion of issues.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Oral discussion of issues. 177.4 Section 177.4... TREASURY (CONTINUED) ADMINISTRATIVE RULINGS General Ruling Procedure § 177.4 Oral discussion of issues. (a... issue or issues involved should indicate that desire in writing at the time the ruling request is...

  2. An Analysis of Higher Order Thinking in Online Discussions

    ERIC Educational Resources Information Center

    McLoughlin, D.; Mynard, J.

    2009-01-01

    This paper describes a study of online discussion forums as tools for promoting higher-order thinking. The study was carried out in a women's university in the United Arab Emirates. Data, in the form of online discussion forum transcripts, were collected over a 20-week semester and were analysed according to a model developed by Garrison,…

  3. Using Text Mining to Characterize Online Discussion Facilitation

    ERIC Educational Resources Information Center

    Ming, Norma; Baumer, Eric

    2011-01-01

    Facilitating class discussions effectively is a critical yet challenging component of instruction, particularly in online environments where student and faculty interaction is limited. Our goals in this research were to identify facilitation strategies that encourage productive discussion, and to explore text mining techniques that can help…

  4. Video from Panel Discussion with Joseph Fraumeni and David Schottenfeld

    Cancer.gov

    Video footage from Panel Discussion with Joseph Fraumeni and David Schottenfeld on Cancer Epidemiology over the Last Half-Century and Thoughts on the Future. The discussion took place on May 11, 2012, when DCEG hosted Dr. Schottenfeld as a Visiting Scholar.

  5. Facilitating Effective Small Group Discussions of Controversial Issues.

    ERIC Educational Resources Information Center

    Hendrix, Jon R.; And Others

    1983-01-01

    Describes four components of a packet of materials designed for small-group discussions on alphafetoprotein (AFP) screening for neural tube defects. Components consist of instructional guidelines for group leader, informational packet on AFP, list of specific discussion questions, and student evaluation form. Copies of these materials are…

  6. Clinical Teaching by Video-Enhanced Study Club Discussion Sessions.

    ERIC Educational Resources Information Center

    Roberts, Douglass B.; And Others

    1988-01-01

    The Loma Linda University School of Dentistry's "study club" method of teaching operative dentistry involves a four-hour clinical operating session and an hour-long discussion immediately following. Videotape recordings of the operative procedures are used successfully in the discussion period to enhance observation and recall. (MSE)

  7. Designs, Management Tactics, and Strategies in Asynchronous Learning Discussions.

    ERIC Educational Resources Information Center

    Tu, Chih-Hsiung; Corry, Michael

    2003-01-01

    Discusses effective designs, management tactics, and strategies to produce ideal asynchronous network discussions that allow contemplation and encourage the development of critical thinking. A model of an online collaborative learning community is applied to implement the designs. A sample of online collaborative moderation guidelines is…

  8. Analysis of the Relevance of Posts in Asynchronous Discussions

    ERIC Educational Resources Information Center

    Azevedo, Breno T.; Reategui, Eliseo; Behar, Patrícia A.

    2014-01-01

    This paper presents ForumMiner, a tool for the automatic analysis of students' posts in asynchronous discussions. ForumMiner uses a text mining system to extract graphs from texts that are given to students as a basis for their discussion. These graphs contain the most relevant terms found in the texts, as well as the relationships between them.…

  9. Block Grants: A Roundtable Discussion. A Commission Report.

    ERIC Educational Resources Information Center

    Advisory Commission on Intergovernmental Relations, Washington, DC.

    This publication is the edited transcript of a four-hour roundtable discussion of the impact of federal block grants. Participating in the discussion were representatives of four organizations conducting major research on five federal block grant programs--the Advisory Commission on Intergovernmental Relations, the Brookings Institution, the…

  10. Student-Facilitators' Roles in Moderating Online Discussions

    ERIC Educational Resources Information Center

    Wang, Qiyun

    2008-01-01

    Intellectual, social, managerial and technical are four commonly reported categories of facilitation in online discussions. The purpose of this study was to investigate whether these four broad categories of facilitation were equally applied in online discussions and which specific skills were perceived to be more important. In this study,…

  11. A summarized discussion of current good manufacturing practice regulations.

    PubMed

    Allen, Loyd V

    2013-01-01

    In light of recent events and discussions of compounding pharmacy, it is important to discuss and understand the purpose of good manufacturing practices. This article provides a summary of the current Good Manufacturing Practice Regulations which were established by the U.S. Food and Drug Administration. PMID:24046937

  12. Frustration and Fulfillment: The Talk of Literature Discussion Groups.

    ERIC Educational Resources Information Center

    Wollman-Bonilla, Julie E.

    Two different groups of sixth graders were studied as one discussed Roald Dahl's "James and the Giant Peach" and the other discussed Mark Twain's "Tom Sawyer." In interviews, students from the two groups offered very different assessments of their experiences, despite the fact that the teacher was the same. The Dahl students, who were remedial…

  13. Assessment of Online Discussion Forums for Law Students

    ERIC Educational Resources Information Center

    McNamara, Judith; Burton, Kelley

    2009-01-01

    This paper goes beyond the existing literature and explores the innovative topic of designing criterion-referenced assessment for online discussion forums. There are several benefits of embedding online discussion forums into subjects including engaging students in collaborative learning, and encouraging deeper analysis, critical thinking and…

  14. Effects of Immediate Instructor Feedback on Group Discussion Participants.

    ERIC Educational Resources Information Center

    Jurma, William E.; Froelich, Deidre L.

    1984-01-01

    Investigated the effects of immediate instructor feedback, via a video display system (ComET system), on the performance of group discussion participants. Found that receivers of immediate feedback were more satisfied with their performances, participated in discussions of higher quality, and were no more anxious than individuals not receiving…

  15. A summarized discussion of current good manufacturing practice regulations.

    PubMed

    Allen, Loyd V

    2013-01-01

    In light of recent events and discussions of compounding pharmacy, it is important to discuss and understand the purpose of good manufacturing practices. This article provides a summary of the current Good Manufacturing Practice Regulations which were established by the U.S. Food and Drug Administration.

  16. Discourse Integration Guided by the "Question under Discussion"

    ERIC Educational Resources Information Center

    Clifton, Charles, Jr.; Frazier, Lyn

    2012-01-01

    What makes a discourse coherent? One potential factor has been discussed in the linguistic literature in terms of a Question under Discussion (QUD). This approach claims that discourse proceeds by continually raising explicit or implicit questions, viewed as sets of alternatives, or competing descriptions of the world. If the interlocutor accepts…

  17. Online Discussion in a Hybrid Information Literacy Credit Course

    ERIC Educational Resources Information Center

    Jacobs, Warren N.

    2007-01-01

    This article discusses how an instruction librarian created an online learning community of adult learners in a hybrid, credit-bearing information literacy course. The Blackboard course management system was utilized for weekly course discussion on ethical issues involving the use of information to promote student engagement in the critical…

  18. Searching for Intertextual Connections in Small Group Text Discussion

    ERIC Educational Resources Information Center

    Chi, Feng-ming

    2012-01-01

    This paper reports the sources for and intentions of intertextuality made by 10 groups of Taiwanese university students in the process of discussing two American stories. Two types of data, small group text discussions and oral interviews, were gathered. The results indicated that participants used diverse sources of intertextual links, and with…

  19. Tobacco-Free School Policy. A Discussion Paper

    ERIC Educational Resources Information Center

    Montana Office of Public Instruction, 2005

    2005-01-01

    This paper provides a background and discussion regarding tobacco-free schools. The paper is intended to enhance discussion about the health benefits to children who attend schools that have a comprehensive tobacco-free school policy. The benefits to the personal health of students are both direct and environmental. Direct health benefits from a…

  20. Focused Interactive Learning: A Tool for Active Class Discussion.

    ERIC Educational Resources Information Center

    Harton, Helen C.; Richardson, Deborah S.; Barreras, Ricardo E.; Rockloff, Matthew J.; Latane, Bibb

    2002-01-01

    Discusses the use of focused interactive learning (FIL), in which students participate in focused discussions with their peers to learn about psychological concepts. Evaluates the use of FIL at Florida Atlantic University (Boca Raton, Florida). Addresses student benefits resulting from this technique. (CMK)

  1. Examining how discussing underrepresentation may mediate female engagement in physics

    NASA Astrophysics Data System (ADS)

    Lock, Robynne M.; Tompkins, Reganne; Hazari, Zahra

    2013-04-01

    Despite the large number of female students taking high school physics, only about a fifth of physics bachelor's degrees are awarded to women. In a previous study, we tested five factors commonly proposed to positively impact female students' choice of a physical science career using multivariate matching methods on national survey data. Four of these factors (having a single-sex class, having female scientist guest speakers, having a female physics teacher, and discussing the work of female scientists) were found to have no effect. The only factor found to have a positive effect was the explicit discussion of the underrepresentation of women in physics. In order to explore this further, a case study of the classes of one teacher reported to discuss the underrepresentation of women was conducted. Two classroom underrepresentation discussions were recorded, students and teacher were interviewed, and relevant student work was collected. Analyzing the case study data, we report on how discussing underrepresentation may mediate female engagement in physics.

  2. Memory conformity: disentangling the steps toward influence during a discussion.

    PubMed

    Gabbert, Fiona; Memon, Amina; Wright, Daniel B

    2006-06-01

    When two people see the same event and discuss it, one person's memory report can influence what the other person subsequently claims to remember. We refer to this as memory conformity. In the present article, two factors underlying the memory conformity effect are investigated. First, are there any characteristics of the dialogue that predict memory conformity? Second, is memory conformity differentially affected when information is encountered that omits, adds to, or contradicts originally encoded items? Participants were tested in pairs. The two members of each pair encoded slightly different versions of complex scenes and discussed them prior to an individual free recall test. The discussions were audiotaped, transcribed, and analyzed. Our most striking finding was that the witness initiating the discussion was most likely to influence the other witness's memory report. Furthermore, witnesses were most likely to be influenced when an additional (previously unseen) item of information was encountered in the discussion.

  3. The SU(r)2 string functions as q-diagrams

    NASA Astrophysics Data System (ADS)

    Genish, Arel; Gepner, Doron

    2016-06-01

    A generalized Roger Ramanujan (GRR) type expression for the characters of A-type parafermions has been a long standing puzzle dating back to conjectures made regarding some of the characters in the 90s. Not long ago we have put forward such GRR type identities describing any of the level two ADE-type generalized parafermions characters at any rank. These characters are the string functions of simply laced Lie algebras at level two, as such, they are also of mathematical interest. In our last joint paper we presented the complete derivation for the D-type generalized parafermions characters identities. Here we generalize our previous discussion and prove the GRR type expressions for the characters of A-type generalized parafermions. To prove the A-type GRR conjecture we study further the q-diagrams, introduced in our last joint paper, and examine the diagrammatic interpretations of known identities among them Slater identities for the characters of the first minimal model, which is the Ising model, and the Bailey lemma.

  4. Cultural differences in use of an electronic discussion group.

    PubMed

    McTavish, Fiona M; Pingree, Suzanne; Hawkins, Robert; Gustafson, David

    2003-01-01

    This article describes how 121 women newly diagnosed with breast cancer used a computer mediated discussion group to cope with their diagnosis. These data are part of a larger data set from a randomized clinical trial assessing the impact of a computer-based system called CHESS (the Comprehensive Health Enhancement Support System) on health outcomes. The larger study found significant improvement in health outcomes for those in the experimental group (those receiving CHESS), especially for women of color. Since discussion group is by far the most heavily used service of CHESS, one might conclude that these benefits (both overall and greater for women of color) should be attributed to amount of discussion group use. This study looks at how women of color and Caucasian women used the CHESS discussion group over the period of the study. Content analysis of messages in the discussion group showed that women of color used the discussion group differently from Caucasian women-they used it less frequently but their messages were more focused on breast cancer, suggesting they used discussion group more instrumentally. PMID:22113904

  5. A Microgenetic Analysis of Classroom Discussion Practices: How Literacy Processes Intermingle in the Negotiation of Meaning in an Online Discussion

    ERIC Educational Resources Information Center

    Vogler, Jane S.; Schallert, Diane L.; Park, Yangjoo; Song, Kwangok; Chiang, Yueh-hui Vanessa; Jordan, Michelle E.; Lee, SoonAh; Cheng, An-Chih Janne; Lee, Ji-Eun; Park, Jeong-bin; Sanders, Anke J. Z.

    2013-01-01

    Unlike previous research on computer-mediated discussions that has focused analysis on the final conversation as a completed product, this study was focused on the process by which the conversation was created. Using screen-capturing software, the on-screen actions of the nine participants in an online classroom discussion were recorded and…

  6. Coastal dynamics off Cabo Pulmo, Baja California Sur, México

    NASA Astrophysics Data System (ADS)

    Trasviña-Castro, A.; Gonzalez-Rodriguez, E.; Zaitsev, O. V.

    2013-05-01

    Cabo Pulmo is the one of the few coral reefs of the Mexican Pacific. It is located to the north of the Tropic of Cancer (at 23.5° N) and therefore formally in the subtropical region. It is part of the Gulf of California but its location near the tip of the Peninsula pose questions about the exchange of properties with the neighboring Pacific Ocean, some of which will be addressed here. It was declared National Park in 1995. Since then it became a no-take zone and a nature reserve for the preservation of the large variety of species found there. We report results based on meteorological and hydrographic observations as well as current measurements gathered between October 2010 and February 2012. These results include the presence of coastal currents forced by the tide, the wind and remote forcing. We believe the latter are associated, sometimes, to the mesoscale circulation of the entrance to the Gulf of California and, at other times, to coastal jets coming from the interior of the Gulf. We use displacement diagrams to discuss the trends of the residual circulation along the coast. During autumn, winter and even in spring the residual coastal flow is towards the Equator. This is attributed to the influence of the Northwesterly winds that blow over the Gulf of California in these months. It is in summer that the coastal residual circulation exhibits a poleward component being more intense during Southeasterly wind events. Finally, we present evidence of coastal exchange with the Pacific Ocean in the form of an intense jet. This coastal jet flows equatorward past Cabo Pulmo, continues towards the Pacific side of the Peninsula and generates offshore filaments when turning the cape.

  7. Integration hybride de transistors a un electron sur un noeud technologique CMOS

    NASA Astrophysics Data System (ADS)

    Jouvet, Nicolas

    This study deals with the hybrid integration of single electron transistors (SET) on a CMOS technology nod. SET devices possess a high potential, especially regarding energy efficiency, but aren't fit to completely replace CMOS components in electrical circuits. However, this problem can be solved through hybrid combination of SETs and MOS, leading to very low operating power circuits, and high integration density. This thesis investigates the use of the nanodamascene process, developed by C. Dubuc, for back-end-of-line (BEOL) SET fabrication, meaning creation of SETs in the oxide encapsulating CMOS devices. The assets the nanodamascene process presents are quite interesting: fabrication of SETs with a large operation margin, high repeatability, and potential for BEOL fabrication. This last point, in particular, makes this process promising. Indeed, it opens the path to the fabrication of numerous layers of SETs, stacked one upon the other, and forming 3D circuits, created on top of 2D CMOS layer. Thus a high gain to existing CMOS wafers could be generated. Devices created through the use of the nanodamascene process, adapted for BEOL SET fabrication, are presented. Limits and improvement perspectives of the technique's transfer are discussed. Electrical characterizations of the devices are also presented. They have demonstrated the created devices functionality, thus validating the successful adaption of the nanodamascene process. They have also allowed for the identification of numerous traps located at the heart of fabricated devices. Fabricated SET devices potential for hybrid SET-CMOS circuits was studied through simulations. Possible architectures showing good potential for early hybrid circuits' realization were identified. Keywords: MOSFET, single electron transistor (SET), nanotechnology, microfabrication, nanodamascene, electrical characterization.

  8. Pretest online discussion groups to augment teaching and learning.

    PubMed

    Kuhn, Jonathan; Hasbargen, Barbara; Miziniak, Halina

    2010-01-01

    Tests and final examination scores of three semesters of control students in a nursing foundation course were compared with tests and final examination scores of three semesters of participating students. Participating students were offered access to an asynchronous pretest online discussion activity with a faculty e-moderator. While the simplified Bloom's revised taxonomy assisted in creating appropriate preparatory test and final examination questions for pretest online discussion, Salmon's five-stage online method provided direction to the e-moderator on how to encourage students to achieve Bloom's higher-order thinking skills during the pretest online discussions. Statistical analysis showed the pretest online discussion activity had a generally positive impact on tests and final examination scores, when controlling for a number of possible confounding variables, including instructor, cumulative grade point average, age, and credit hours. PMID:20736728

  9. PNNL Expert Doug McMakin Discusses Millimeter Wave Technology

    ScienceCinema

    Doug McMakin

    2016-07-12

    Electrical Engineer Doug McMakin discusses Millimeter Wave Holographic technology, which uses non-harmful, ultrahigh-frequency radio waves to penetrate clothing to detect and identify concealed objects, as well as obtain accurate body measurements.

  10. Focus group discussion: a tool for health and medical research.

    PubMed

    Wong, L P

    2008-03-01

    Focus group discussion is a research methodology in which a small group of participants gather to discuss a specified topic or an issue to generate data. The main characteristic of a focus group is the interaction between the moderator and the group, as well as the interaction between group members. The objective is to give the researcher an understanding of the participants' perspective on the topic in discussion. Focus groups are rapidly gaining popularity in health and medical research. This paper presents a general introduction of the use of focus groups as a research tool within the context of health research, with the intention of promoting its use among researchers in healthcare. A detailed methodology for the conduct of focus groups and analysis of focus group data are discussed. The potentials and limitations of this qualitative research technique are also highlighted.

  11. Responding to Financial Reductions Reports from the Discussion Groups.

    ERIC Educational Resources Information Center

    International Journal of Institutional Management in Higher Education, 1986

    1986-01-01

    The discussions of participants of a workshop concerning the effects of retrenchment on teaching and research, institutional policies, and institutional operations in European higher educational institutions are summarized. (MSE)

  12. Are You Ready To Discuss IT Outsourcing on Your Campus?

    ERIC Educational Resources Information Center

    McCord, Alan

    2002-01-01

    Explores why the idea of outsourcing campus information technology (IT) services rouses opinions and passions best handled by informed dialogue. Discusses how to conduct this dialog, including common myths about outsourcing and useful lessons. (EV)

  13. PNNL Expert Doug McMakin Discusses Millimeter Wave Technology

    SciTech Connect

    Doug McMakin

    2011-10-01

    Electrical Engineer Doug McMakin discusses Millimeter Wave Holographic technology, which uses non-harmful, ultrahigh-frequency radio waves to penetrate clothing to detect and identify concealed objects, as well as obtain accurate body measurements.

  14. Ethical issues in risk communication: continuing the discussion.

    PubMed

    Johnson, B B

    1999-06-01

    Proposed in this article is one possible framework for classifying multiple types of ethical issues in risk communication research and practice to help continue a discussion initiated in 1990 by Morgan and Lave. Some of the questions that each stage of the process for planning risk communication strategies appears to pose for ethics are discussed (e.g., selecting issues to be communicated, knowing the issue, dealing with constraints). Also discussed briefly are some issues raised by the possibility that risk communicators aspire to the status of a profession. The purpose is to foster discussion rather than issue a conclusive statement on the topic, because its very nature makes a definitive pronouncement indefensible. PMID:10765408

  15. Mindfulness and discussing "thorny" issues in the classroom

    NASA Astrophysics Data System (ADS)

    Alexakos, Konstantinos; Pride, Leah D.; Amat, Arnau; Tsetsakos, Panagiota; Lee, Kristi J.; Paylor-Smith, Christian; Zapata, Corinna; Wright, Shequana; Smith, Theila

    2016-04-01

    Being in the moment, showing compassion, being non-judgmental, acknowledging deep emotional challenges without getting stuck: these are mindfulness characteristics important to us as teachers, yet not often included in teacher preparation. These concerns become magnified when we focus on difficult knowledge and thorny issues, like topics related to gender and race. Using a sociocultural framework, we address how mindfulness, heuristics, and other contemplative practices can be adopted to create safe, supporting, and healing spaces for such complex, often emotionally painful discussions. Participant narratives are used extensively to provide a voice to those marginalized or hurt. Drawing from these narratives and their experience in discussing thorny issues, we put forth possible solutions and interventions that can create spaces that encourage and support critical discourse through mindful practices. The development of a heuristic for discussing thorny issues whose characteristics can be adopted by interested teachers and educators to help frame and mediate this type of difficult discussion is an outcome of this research.

  16. Discussing Animal Rights and Animal Research in the Classroom.

    ERIC Educational Resources Information Center

    Herzog, Harold A.

    1990-01-01

    Reviews two prominent philosophical justifications for animal liberation and describes a simulation that facilitates class discussion of animal research issues. Students reported that the exercise increased their awareness of the issues and of the complexity of making ethical decisions. (DB)

  17. Mindfulness and discussing "thorny" issues in the classroom

    NASA Astrophysics Data System (ADS)

    Alexakos, Konstantinos; Pride, Leah D.; Amat, Arnau; Tsetsakos, Panagiota; Lee, Kristi J.; Paylor-Smith, Christian; Zapata, Corinna; Wright, Shequana; Smith, Theila

    2016-09-01

    Being in the moment, showing compassion, being non-judgmental, acknowledging deep emotional challenges without getting stuck: these are mindfulness characteristics important to us as teachers, yet not often included in teacher preparation. These concerns become magnified when we focus on difficult knowledge and thorny issues, like topics related to gender and race. Using a sociocultural framework, we address how mindfulness, heuristics, and other contemplative practices can be adopted to create safe, supporting, and healing spaces for such complex, often emotionally painful discussions. Participant narratives are used extensively to provide a voice to those marginalized or hurt. Drawing from these narratives and their experience in discussing thorny issues, we put forth possible solutions and interventions that can create spaces that encourage and support critical discourse through mindful practices. The development of a heuristic for discussing thorny issues whose characteristics can be adopted by interested teachers and educators to help frame and mediate this type of difficult discussion is an outcome of this research.

  18. Using Context Variety and Students' Discussions in Recognizing Statistical Situations

    ERIC Educational Resources Information Center

    Silva, José Luis Ángel Rodríguez; Aguilar, Mario Sánchez

    2016-01-01

    We present a proposal for helping students to cope with statistical word problems related to the classification of different cases of confidence intervals. The proposal promotes an environment where students can explicitly discuss the reasons underlying their classification of cases.

  19. IRIS Toxicological Review of Trichloroethylene (Interagency Science Discussion Draft)

    EPA Science Inventory

    EPA is releasing the draft report, Toxicological Review of Trichloroethylene, that was distributed to Federal agencies and White House Offices for comment during the Science Discussion step of the IRIS Assessment Development Process. Comments received from other Federal agencies ...

  20. Cochlear Macro- and Micromechanics—A Moderated Discussion

    NASA Astrophysics Data System (ADS)

    Dong, Wei; Ruggero, Mario A.

    2011-11-01

    A discussion moderated by the authors on the topic "Cochlear Macro- and Micromechanics" was held on 19 July 2011 at the 11th International Mechanics of Hearing Workshop in Williamstown, Massachusetts. The paper provides an edited transcript of the session.

  1. ATP-sensitive K(+) channels (Kir6.1/SUR1) regulate gap junctional coupling in cochlear-supporting cells.

    PubMed

    Blödow, Alexander; Begandt, Daniela; Bader, Almke; Becker, Annegret; Burghard, Alice; Kühne, Daniela; Kral, Andrej; Ngezahayo, Anaclet

    2016-07-01

    Using the double whole-cell patch-clamp technique, we found that the absence of intracellular ATP led to gap junction uncoupling in cochlear-supporting Hensen cells. The uncoupling was observed as a progressive reduction of the gap junctional electrical conductance from a starting value of approximately 40 nS to less than 0.04 nS within 10-20 min. The conductance rundown was partly avoided by at least 3 mM ATP and completely suppressed by 5 mM ATP or 5'-adenylyl-imidodiphosphate (AMP-PNP), the non-hydrolysable ATP analog, in the pipette filling solution, suggesting that ATP was needed as ligand and not as a hydrolysable energy supplier or substrate for enzymatic reactions. The effect of intracellular ATP was mimicked by the external application of barium, a nonselective blocker of inwardly rectifying K(+) (Kir) channels, and glibenclamide, an inhibitor of the ATP-sensitive Kir channels (KATP). Moreover a Ba(2+)-sensitive whole-cell inward current was observed in absence of internal ATP. We propose that the internal ATP kept the KATP channels in a closed state, thereby maintaining the gap junction coupling of Hensen cells. The immunostaining of guinea pig cochlear tissue revealed for the first time the expression of the KATP channel subunits Kir6.1 and SUR1 in Hensen cells and supported the proposed hypothesis. The results suggest that KATP channels, as regulator of the gap junction coupling in Hensen cells, could be the physiological link between the metabolic state of the supporting cells and K(+) recycling in the organ of Corti. PMID:27030354

  2. K-Ar ages confirm Pliocene age for oldest Neogene marine strata near Loreto, Baja California Sur, Mexico

    SciTech Connect

    McLean, H.

    1987-05-01

    Beds of pumiceous tuff interbedded with mollusk-rich sedimentary rocks provide new age constraints on the timing of the late Neogene subsidence and marine transgression a few kilometers north of Loreto, Baja California Sur, Mexico. The lower part of the Neogene section consists of approximately 1500 m of early to middle Miocene nonmarine volcanic-derived sandstone, breccia, and porphyritic andesite and dacite lavas, called the Comondu Formation or Comondu Group by previous workers. The Miocene rocks are unconformably overlain by nearly 1000 m of predominantly marine sandstone, siltstone, conglomerate, coquina, and tuff of Pliocene age. This 1000-m section grades upward from unfossiliferous fanglomerate, sandstone, and pelitic red beds that are interpreted to be nonmarine into mollusk-rich marine strata; this sequence indicates that marine transgression occurred within the Pliocene section. Plagioclase and hornblende from three pumiceous tuff beds stratigraphically located near the base, middle, and top of the marine section yield K-Ar ages of 3.2, 1.9, and 1.8 Ma, respectively; these ages are similar to Pliocene ages indicated by reconnaissance studies of ostracods, diatoms, and foraminifers. The diatoms indicate open-ocean waters and the foraminifers indicate outer shelf depth. Ostracods, oysters, pectens, and other fossil bivalves seem to indicate a shallow-water embayment. Lateral distribution of nonmarine and marine facies suggests a paleoenvironment in which alluvial fans fed coarse debris into a series of coastal fan deltas. The Pliocene basin may have been a largely landlocked embayment similar to the modern Bahia Concepcion, located 70 km north of Loreto. Marine and volcanic rocks are assumed to be associated with the opening of the Gulf of California. If this assumption is correct, the beds near Loreto suggest that the opening occurred during the Pliocene.

  3. Transmission Sur Fibres Optiques Dans Un Systeme D'Archivage Et De Communication D'Images Pour Des Applications Medicales

    NASA Astrophysics Data System (ADS)

    Aaron, Gilles; Bonnard, Rene

    1984-03-01

    Dans l'hOpital, le besoin d'un reseau de communication electronique ne cesse de crottre au fur et a mesure de la numerisation des images. Ce reseau local a pour but de relier quelques sources d'images telles la radiologie numerique, la tomodensitometrie, la resonance magnetique nucleaire, l'echographie ultraso-nore etc..., a un systme d'archivage. Des consoles de visualisation interacti-ves peuvent etre utilisees dans les salles d'examens, les bureaux des medecins et les services de soins. Dans un tel systme, trois caracteristiques princi-pales doivent etre prises en compte le debit, la longueur du cable et le nombre de connexions. - Le debit est tr?)s important, en effet, un temps de reponse maxima de quel-ques secondes doit etre garanti pour des images de plusieurs millions d'ele-ments binaires. - La distance entre connexions peut etre de quelques km dans certains grands hopitaux. - Le nombre de connexions au reseau ne depasse jamais quelques dizaines car les sources d'images et les unites de traitement representent des materiels importants, par ailleurs les consoles de visualisation simples peuvent etre groupees en grappe. Toutes ces conditions sont remplies par les transmissions sur fibres optiques. Selon la topologie et la methode d'accNs, deux solutions peuvent etre envisa-gees : - Anneau actif - Etoile active ou passive Enfin, les developpements de Thomson-CSF en composants pour transmissions optiques pour les grands reseaux de tel4distribution nous apportent un support technologique et une production de masse qui diminuera les collts du materiel.

  4. ATP-sensitive K(+) channels (Kir6.1/SUR1) regulate gap junctional coupling in cochlear-supporting cells.

    PubMed

    Blödow, Alexander; Begandt, Daniela; Bader, Almke; Becker, Annegret; Burghard, Alice; Kühne, Daniela; Kral, Andrej; Ngezahayo, Anaclet

    2016-07-01

    Using the double whole-cell patch-clamp technique, we found that the absence of intracellular ATP led to gap junction uncoupling in cochlear-supporting Hensen cells. The uncoupling was observed as a progressive reduction of the gap junctional electrical conductance from a starting value of approximately 40 nS to less than 0.04 nS within 10-20 min. The conductance rundown was partly avoided by at least 3 mM ATP and completely suppressed by 5 mM ATP or 5'-adenylyl-imidodiphosphate (AMP-PNP), the non-hydrolysable ATP analog, in the pipette filling solution, suggesting that ATP was needed as ligand and not as a hydrolysable energy supplier or substrate for enzymatic reactions. The effect of intracellular ATP was mimicked by the external application of barium, a nonselective blocker of inwardly rectifying K(+) (Kir) channels, and glibenclamide, an inhibitor of the ATP-sensitive Kir channels (KATP). Moreover a Ba(2+)-sensitive whole-cell inward current was observed in absence of internal ATP. We propose that the internal ATP kept the KATP channels in a closed state, thereby maintaining the gap junction coupling of Hensen cells. The immunostaining of guinea pig cochlear tissue revealed for the first time the expression of the KATP channel subunits Kir6.1 and SUR1 in Hensen cells and supported the proposed hypothesis. The results suggest that KATP channels, as regulator of the gap junction coupling in Hensen cells, could be the physiological link between the metabolic state of the supporting cells and K(+) recycling in the organ of Corti.

  5. Considérations nosographiques sur le délire d'infestation parasitaire à travers trois observations cliniques

    PubMed Central

    Berhili, Nabil; Bout, Amine; Hlal, Hayat; Aarab, Chadya; Aalouane, Rachid; Rammouz, Ismail

    2016-01-01

    Le syndrome d'Ekbom, ou délire d'infestation parasitaire, est une pathologie rare, caractérisée par la conviction inébranlable d'avoir une peau infestée d'insectes ou de parasites. Il s'agit d'un délire monothématique à mécanisme hallucinatoire qui touche typiquement les femmes d’âge avancé. Nous rapportons les cas de trois patients qui présentent un délire d'infestation parasitaire dans des contextes cliniques différents. Le premier patient souffre d'un délire d'infestation isolé correspondant à la forme décrite par Karl Ekbom. Le deuxième cas présente un délire d'infestation secondaire, s'inscrivant dans le cadre d'une leuco-encéphalopathie de type CADASIL. Enfin, le troisième patient se présente dans un tableau évocateur d'un épisode dépressif avec une caractéristique psychotique qui intègre le délire d'infestation. Ces trois vignettes cliniques illustrent parfaitement le caractère trans-nosographique de ce syndrome ainsi que les difficultés de prise en charge de ces patients, tant au niveau de l'alliance thérapeutique que sur le plan des choix en matière de traitement pharmacologiques. PMID:27642468

  6. Boron and strontium isotope compositions of groundwater from the La Paz arid coastal aquifer, Baja California Sur, Mexico

    NASA Astrophysics Data System (ADS)

    Mahlknecht, Jürgen; Rosner, Martin; Meixner, Anette

    2016-04-01

    In groundwater studies boron and strontium isotopic compositions can be used to identify natural and anthropogenic sources as well as processes related to groundwater recharge, flow and mixing. The La Paz arid costal aquifer in Baja California Sur, Mexico, is the most important source of drinking and irrigation water for La Paz area and suffers from anthropogenic contamination and intensive exploitation of the aquifer causing seawater intrusion and general groundwater abatement. The relatively un-radiogenic 87Sr/86Sr isotope ratios of the La Paz groundwater range in a narrow field between 0.7054 and 0.7062. In contrast to strontium the boron isotope composition displays a large variability between +27 and +55 permil d11B. The relatively low 87Sr/86Sr ratios of the La Paz groundwater highlight a significant contribution of strontium derived from local terrestrial sediments and igneous rocks with known 87Sr/86Sr ratios between 0.705 and 0.7035. The large variability of d11B values indicate that multiple sources and processes determine the boron isotope composition of La Paz groundwater. Rainwater (high d11B), seawater (~+40 permil) due to seawater intrusions, wastewater (low to medium d11B) and boron derived from the local geology (low to medium d11B) explain most of the observed groundwater d11B variability. However, d11B values higher than modern seawater point to significant boron isotope fractionation by preferential absorption of 10B onto clay minerals during the evolution of some groundwater samples. Due to low boron concentrations in rainwater a significant contribution of 11B-rich rainwater (>+40 permil) on the La Paz groundwater is unlikely.

  7. A discussion of molecular biology methods for protein engineering.

    PubMed

    Zawaira, Alexander; Pooran, Anil; Barichievy, Samantha; Chopera, Denis

    2012-05-01

    A number of molecular biology techniques are available to generate variants from a particular start gene for eventual protein expression. We discuss the basic principles of these methods in a repertoire that may be used to achieve the elemental steps in protein engineering. These include site-directed, deletion and insertion mutagenesis. We provide detailed case studies, drawn from our own experiences, packaged together with conceptual discussions and include an analysis of the techniques presented with regards to their uses in protein engineering.

  8. Discussion of "Biomedical informatics: we are what we publish".

    PubMed

    Geissbuhler, A; Hammond, W E; Hasman, A; Hussein, R; Koppel, R; Kulikowski, C A; Maojo, V; Martin-Sanchez, F; Moorman, P W; Moura, L A; de Quirós, F G B; Schuemie, M J; Smith, B; Talmon, J

    2013-01-01

    This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Biomedical Informatics: We Are What We Publish", written by Peter L. Elkin, Steven H. Brown, and Graham Wright. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the Elkin et al. paper. In subsequent issues the discussion can continue through letters to the editor. PMID:24310397

  9. Discussion of "Computational Electrocardiography: Revisiting Holter ECG Monitoring".

    PubMed

    Baumgartner, Christian; Caiani, Enrico G; Dickhaus, Hartmut; Kulikowski, Casimir A; Schiecke, Karin; van Bemmel, Jan H; Witte, Herbert

    2016-08-01

    This article is part of a For-Discussion-Section of Methods of Information in Medicine about the paper "Computational Electrocardiography: Revisiting Holter ECG Monitoring" written by Thomas M. Deserno and Nikolaus Marx. It is introduced by an editorial. This article contains the combined commentaries invited to independently comment on the paper of Deserno and Marx. In subsequent issues the discussion can continue through letters to the editor.

  10. Creating discussions with classroom voting in linear algebra

    NASA Astrophysics Data System (ADS)

    Cline, Kelly; Zullo, Holly; Duncan, Jonathan; Stewart, Ann; Snipes, Marie

    2013-12-01

    We present a study of classroom voting in linear algebra, in which the instructors posed multiple-choice questions to the class and then allowed a few minutes for consideration and small-group discussion. After each student in the class voted on the correct answer using a classroom response system, a set of clickers, the instructor then guided a class-wide discussion of the results. We recorded the percentage of students voting for each option on each question used in 18 sections of linear algebra, taught by 10 instructors, at 8 institutions, over the course of 5 years, together recording the results of 781 votes on a collection of 311 questions. To find the questions most likely to provoke significant discussions, we identify the six questions for which votes were most broadly distributed. Here we present these questions, we discuss how we used them to advance student learning, and we discuss the common features of these questions, to identify why they were so good at stimulating discussions.

  11. Maintaining Live Discussion in Two-Stage Open Peer Review

    PubMed Central

    Sandewall, Erik

    2011-01-01

    Open peer review has been proposed for a number of reasons, in particular, for increasing the transparency of the article selection process for a journal, and for obtaining a broader basis for feedback to the authors and for the acceptance decision. The review discussion may also in itself have a value for the research community. These goals rely on the existence of a lively review discussion, but several experiments with open-process peer review in recent years have encountered the problem of faltering review discussions. The present article addresses the question of how lively review discussion may be fostered by relating the experience of the journal Electronic Transactions on Artificial Intelligence (ETAI) which was an early experiment with open peer review. Factors influencing the discussion activity are identified. It is observed that it is more difficult to obtain lively discussion when the number of contributed articles increases, which implies difficulties for scaling up the open peer review model. Suggestions are made for how this difficulty may be overcome. PMID:22363282

  12. Etudes sur la gravitation: Theories alternatives en 2+1 et 3+1 dimensions

    NASA Astrophysics Data System (ADS)

    Edery, Ariel

    to study a 2 + 1 dimensional model. However, in 2 + 1 dimensions, the analog to Einstein gravity is trivial. The space-time outside sources is flat and particles at rest do not interact. The odd dimensional space-time allows one to include a gravitational Chern-Simons term called a topological mass term because it gives mass to the graviton. In article three and four, we consider localized mass and spin sources in the full non-linear theory. We obtain solutions for both of Vuorio's sectors. In article 3 we demonstrate that delta function sources, while allowed in the linearized theory are not consistent with the full non-linear field equations. In article four, we consider how to embed point sources in Vuorio's cosmological sector and discuss the metric solution for the case when observers are near and far away from the source. (Abstract shortened by UMI.)

  13. The pioneer woman's view of migraine: Elizabeth Garrett Anderson's thesis "Sur la migraine".

    PubMed

    Wilkinson, M; Isler, H

    1999-01-01

    translate it but, after discussion, we decided on a joint effort (95% of the translation is by M.W.; very few details were changed, and some footnotes added for better understanding). We think that E.G.A.'s text is a classic, showing profound understanding, sound practical advice, and also, in its theoretical part, the limits of neurophysiological knowledge in Paris when Brown-Sequard was "charge des cours" there. We may add that in her various examinations she had to answer questions, in French, on the use of footprints by the police, the general nature of fishes, toxic fishes, electric fishes, cod liver oil, and the secretion of tears. She earned much applause from the public, which consisted of male French students, and the overt appreciation of Paul Broca, head examiner, and Dr Wurtz, the Dean of the Faculte de Médecine. The impact of her thesis in the 19th century was modest. It appears to be rather marginal in the German literature of the early 20th century, but it has imprinted the management of migraine at the City of London Migraine Clinic in the last thirty years. The importance of nutrition, regular meals, regular habits, the need to supplement analgesics with antiemetics, and the treatment of the attack with rest, and great quantities of hot tea, were certainly related to E.G.A.'s doctrine. The internationally prevailing recommendation to give antiemetics, and then only analgesics, as well as the combination of both in one tablet, may thus be traced back to E.G.A. via the teachings of M.W. and Nat Blau.

  14. Technique distribuee de gestion de la charge sur le reseau electrique et ring-tree: Un nouveau systeme de communication P2P

    NASA Astrophysics Data System (ADS)

    Ayoub, Simon

    Le reseau de distribution et de transport de l'electricite se modernise dans plusieurs pays dont le Canada. La nouvelle generation de ce reseau que l'on appelle smart grid, permet entre autre l'automatisation de la production, de la distribution et de la gestion de la charge chez les clients. D'un autre cote, des appareils domestiques intelligents munis d'une interface de communication pour des applications du smart grid commencent a apparaitre sur le marche. Ces appareils intelligents pourraient creer une communaute virtuelle pour optimiser leurs consommations d'une facon distribuee. La gestion distribuee de ces charges intelligentes necessite la communication entre un grand nombre d'equipements electriques. Ceci represente un defi important a relever surtout si on ne veut pas augmenter le cout de l'infrastructure et de la maintenance. Lors de cette these deux systemes distincts ont ete concus : un systeme de communication peer-to-peer, appele Ring-Tree, permettant la communication entre un nombre important de noeuds (jusqu'a de l'ordre de grandeur du million) tel que des appareils electriques communicants et une technique distribuee de gestion de la charge sur le reseau electrique. Le systeme de communication Ring-Tree inclut une nouvelle topologie reseau qui n'a jamais ete definie ou exploitee auparavant. Il inclut egalement des algorithmes pour la creation, l'exploitation et la maintenance de ce reseau. Il est suffisamment simple pour etre mis en oeuvre sur des controleurs associes aux dispositifs tels que des chauffe-eaux, chauffage a accumulation, bornes de recharges electriques, etc. Il n'utilise pas un serveur centralise (ou tres peu, seulement lorsqu'un noeud veut rejoindre le reseau). Il offre une solution distribuee qui peut etre mise en oeuvre sans deploiement d'une infrastructure autre que les controleurs sur les dispositifs vises. Finalement, un temps de reponse de quelques secondes pour atteindre 1'ensemble du reseau peut etre obtenu, ce qui est

  15. Effets potentiels d’un modèle rationnel de prescription sur les dépenses nationales en santé

    PubMed Central

    Littman, Jordan; Halil, Roland

    2016-01-01

    Résumé Objectif Estimer les économies que pourrait engendrer la mise en œuvre d’un modèle rationnel de prescription pour des classes de médicaments équivalents sur les plans de l’efficacité, de la toxicité et de la commodité. Conception L’Institut canadien d’information sur la santé a fourni des renseignements sur les 10 principales classes de médicaments en fonction des dépenses annuelles qui leur sont attribuables. Ces classes ont été examinées en vue de leur inclusion potentielle dans l’étude selon qu’il était possible de comparer les médicaments à l’intérieur d’une même classe. Lorsqu’à la suite d’une recherche documentaire, une équivalence a été établie en fonction de l’efficacité, de la toxicité et de la commodité des médicaments, les données annuelles sur les prescriptions ont été recueillies à partir de la base de données du Système national d’information sur l’utilisation des médicaments prescrits. Les économies potentielles de coûts ont ensuite été calculées en comparant les parts de marché actuelles avec les parts potentielles futures de ce marché. Contexte Le Canada. Principaux paramètres à l’étude Les différences estimées dans les dépenses que produirait un modèle rationnel de prescription. Résultats Une équivalence a été établie sur les plans de l’efficacité, de la toxicité et de la commodité dans les classes de statines, d’inhibiteurs de la pompe à protons, d’inhibiteurs de l’enzyme de conversion de l’angiotensine et d’inhibiteurs sélectifs du recaptage de l’angiotensine. Les dépenses annuelles totales dans ces classes se situent à 856 millions $ dans les programmes publics de médicaments et à 1,97 milliard $ environ à l’échelle nationale. Grâce à des prescriptions rationnelles, on estime que les économies annuelles pourraient atteindre 222 millions $ pour les programmes publics et 521 millions $ à l’échelle nationale. Conclusion La

  16. Effets de L'anisotropie Cristalline et du Desordre Controle Sur les Proprietes Optiques et Phononiques des Composes Semiconducteurs ZIRCONIUM(1-X) Hafnium(x) SOUFRE(3)

    NASA Astrophysics Data System (ADS)

    Ait-Ouali, Abderrahmane

    Dans ce travail, nous presentons l'etude de l'effet de l'anisotropie cristalline et du desordre substitutionnel controle sur les proprietes electroniques et vibrationnelles des composes semiconducteurs Zr_{rm 1-x}Hf_{x} S_3. Les proprietes phononiques sont ete etudiees en spectroscopie Raman. Les mesures systematiques des spectres polarises de tous les composes nous ont permis d'identifier tous les phonons predits par la theorie des groupes et de suivre l'evolution de leur frequence avec la concentration de hafnium. L'analyse plus approfondie par un procede de lissage des spectres nous a permis detudier l'effet du desordre controle sur la largeur des modes phononiques. Les resultats de cette analyse ont ete confrontes aux predictions d'un modele developpe pour une chai ne diatomique desordonnee et ameliore suite a nos observations experimentales. La forme en cloche predite par ce dernier pour la variation de la largeur du mode optique de la chai ne est observee pour trois phonons de symetrie Bg. L'accord est excellent pour X > 0.5 pour deux des trois modes et ce, sans aucun parametre ajustable. Cette etude nous a permis, d'une part, de conclure que les modes Bg se comportent comme s'ils etaient sur une chai ne isolee et que, par consequent, les deux chai nes composant la cellule unite de nos cristaux sont tres faiblement liees et, d'autre part, de confirmer la symetrie des modes telle que deduite des spectres polarises. Les proprietes electroniques du ZrS_3 ont ete etudiees par des mesures polarisees du coefficient d'absorption pres de son gap indirect. L'evolution des spectres avec la temperature nous a permis d'identifier deux gaps paralleles differents et un gap perpendiculaire confirmant ainsi le modele de la structure de bande base sur les etats electroniques moleculaires de l'ion (S _2)^2. L'analyse detaillee des differentes structures du coefficient d'absorption indique clairement un caractere bidimensionnel du gap indirect. L'effet du desordre

  17. Scaffolding scientific discussion using socially relevant representations in networked multimedia

    NASA Astrophysics Data System (ADS)

    Hoadley, Christopher M.

    1999-11-01

    How do students make use of social cues when learning on the computer? This work examines how students in a middle-school science course learned through on-line peer discussion. Cognitive accounts of collaboration stress interacting with ideas, while socially situated accounts stress the interpersonal context. The design of electronic environments allows investigation into the interrelation of cognitive and social dimensions. I use on-line peer discussion to investigate how socially relevant representations in interfaces can aid learning. First, I identify some of the variables that affect individual participation in on-line discussion, including interface features. Individual participation is predicted by student attitudes towards learning from peers. Second, I describe the range of group outcomes for these on-line discussions. There is a large effect of discussion group on learning outcomes which is not reducible to group composition or gross measures of group process. Third, I characterize how students (individually) construct understanding from these group discussions. Learning in the on-line discussions is shown to be a result of sustained interaction over time, not merely encountering or expressing ideas. Experimental manipulations in the types of social cues available to students suggest that many students do use socially relevant representations to support their understanding of multiple viewpoints and science reasoning. Personalizing scientific disputes can afford reflection on the nature of scientific discovery and advance. While there are many individual differences in how social representations are used by students in learning, overall learning benefits for certain social representations can be shown. This work has profound implications for design of collaborative instructional methods, equitable access to science learning, design of instructional technology, and understanding of learning and cognition in social settings.

  18. Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel.

    PubMed

    Cooper, Paige E; Sala-Rabanal, Monica; Lee, Sun Joo; Nichols, Colin G

    2015-12-01

    Cantú syndrome (CS) is a rare disease characterized by congenital hypertrichosis, distinct facial features, osteochondrodysplasia, and cardiac defects. Recent genetic analysis has revealed that the majority of CS patients carry a missense mutation in ABCC9, which codes for the sulfonylurea receptor SUR2. SUR2 subunits couple with Kir6.x, inwardly rectifying potassium pore-forming subunits, to form adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channels, which link cell metabolism to membrane excitability in a variety of tissues including vascular smooth muscle, skeletal muscle, and the heart. The functional consequences of multiple uncharacterized CS mutations remain unclear. Here, we have focused on determining the functional consequences of three documented human CS-associated ABCC9 mutations: human P432L, A478V, and C1043Y. The mutations were engineered in the equivalent position in rat SUR2A (P429L, A475V, and C1039Y), and each was coexpressed with mouse Kir6.2. Using macroscopic rubidium ((86)Rb(+)) efflux assays, we show that K(ATP) channels formed with P429L, A475V, or C1039Y mutants enhance K(ATP) activity compared with wild-type (WT) channels. We used inside-out patch-clamp electrophysiology to measure channel sensitivity to ATP inhibition and to MgADP activation. For P429L and A475V mutants, sensitivity to ATP inhibition was comparable to WT channels, but activation by MgADP was significantly greater. C1039Y-dependent channels were significantly less sensitive to inhibition by ATP or by glibenclamide, but MgADP activation was comparable to WT. The results indicate that these three CS mutations all lead to overactive K(ATP) channels, but at least two mechanisms underlie the observed gain of function: decreased ATP inhibition and enhanced MgADP activation. PMID:26621776

  19. Differential mechanisms of Cantú syndrome–associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel

    PubMed Central

    Cooper, Paige E.; Sala-Rabanal, Monica; Lee, Sun Joo

    2015-01-01

    Cantú syndrome (CS) is a rare disease characterized by congenital hypertrichosis, distinct facial features, osteochondrodysplasia, and cardiac defects. Recent genetic analysis has revealed that the majority of CS patients carry a missense mutation in ABCC9, which codes for the sulfonylurea receptor SUR2. SUR2 subunits couple with Kir6.x, inwardly rectifying potassium pore-forming subunits, to form adenosine triphosphate (ATP)-sensitive potassium (KATP) channels, which link cell metabolism to membrane excitability in a variety of tissues including vascular smooth muscle, skeletal muscle, and the heart. The functional consequences of multiple uncharacterized CS mutations remain unclear. Here, we have focused on determining the functional consequences of three documented human CS-associated ABCC9 mutations: human P432L, A478V, and C1043Y. The mutations were engineered in the equivalent position in rat SUR2A (P429L, A475V, and C1039Y), and each was coexpressed with mouse Kir6.2. Using macroscopic rubidium (86Rb+) efflux assays, we show that KATP channels formed with P429L, A475V, or C1039Y mutants enhance KATP activity compared with wild-type (WT) channels. We used inside-out patch-clamp electrophysiology to measure channel sensitivity to ATP inhibition and to MgADP activation. For P429L and A475V mutants, sensitivity to ATP inhibition was comparable to WT channels, but activation by MgADP was significantly greater. C1039Y-dependent channels were significantly less sensitive to inhibition by ATP or by glibenclamide, but MgADP activation was comparable to WT. The results indicate that these three CS mutations all lead to overactive KATP channels, but at least two mechanisms underlie the observed gain of function: decreased ATP inhibition and enhanced MgADP activation. PMID:26621776

  20. Investigation of the role of the BAM complex and SurA chaperone in outer-membrane protein biogenesis and type III secretion system expression in Salmonella.

    PubMed

    Fardini, Yann; Trotereau, Jérôme; Bottreau, Elisabeth; Souchard, Charlène; Velge, Philippe; Virlogeux-Payant, Isabelle

    2009-05-01

    In Escherichia coli, the assembly of outer-membrane proteins (OMP) requires the BAM complex and periplasmic chaperones, such as SurA or DegP. Previous work has suggested a potential link between OMP assembly and expression of the genes encoding type-III secretion systems. In order to test this hypothesis, we studied the role of the different lipoproteins of the BAM complex (i.e. BamB, BamC, BamD and BamE), and the periplasmic chaperones SurA and DegP, in these two phenotypes in Salmonella. Analysis of the corresponding deletion mutants showed that, as previously described with the DeltabamB mutant, BamD, SurA and, to a lesser extent, BamE play a role in outer-membrane biogenesis in Salmonella Enteritidis, while the membrane was not notably disturbed in DeltabamC and DeltadegP mutants. Interestingly, we found that BamD is not essential in Salmonella, unlike its homologues in Escherichia coli and Neisseria gonorrhoeae. In contrast, BamD was the only protein required for full expression of T3SS-1 and flagella, as demonstrated by transcriptional analysis of the genes involved in the biosynthesis of these T3SSs. In line with this finding, bamD mutants showed a reduced secretion of effector proteins by these T3SSs, and a reduced ability to invade HT-29 cells. As DeltasurA and DeltabamE mutants had lower levels of OMPs in their outer membrane, but showed no alteration in T3SS-1 and flagella expression, these results demonstrate the absence of a systematic link between an OMP assembly defect and the downregulation of T3SSs in Salmonella; therefore, this link appears to be related to a more specific mechanism that involves at least BamB and BamD. PMID:19372159

  1. Superposition tridimensionnelle (3-D) sur la base du crâne pour l’évaluation longitudinale des effets de la croissance et du traitement

    PubMed Central

    Cevidanes, Lucia H.S.; Styner, Martin; Proffit, William R.; Ngom, Traduit par Papa Ibrahima

    2010-01-01

    RÉSUMÉ – Pour évaluer les modifications liées à la croissance ou au traitement, il est nécessaire de superposer les céphalogrammes successifs sur une structure stable. En céphalométrie bidimensionnelle (2-D), la base du crâne est souvent utilisée pour les superpositions parce que les changements qu’elle subit après le développement cérébral sont mineurs. Toutefois, sur les céphalogrammes de profil et de face, les points de repère basicraniens sont peu fiables. Dans cet article, nous présentons une nouvelle méthode de superposition tridimensionnelle (3-D) basée sur un enregistrement entièrement automatisé des intensités de voxels, au niveau de la surface de la base du crâne. Le progiciel utilisé permet l’évaluation quantitative des modifications qui apparaissent dans le temps, grâce au calcul de la distance euclidienne entre les surfaces du modèle tridimensionnel. Il permet également l’appréciation visuelle de l’emplacement et de l’importance des modifications au niveau des maxillaires, grâce à une surimpression graphique. Les modifications sont visualisées par comparaison à des tables de correspondance de couleur. On peut ainsi réaliser une étude détaillée des modes d’adaptation chez les patients dont la croissance et/ou le traitement ont provoqué des modifications squelettiques cliniquement significatives. PMID:19954732

  2. Communique: Special Issue on the International Network for Cooperation in Northern Science Created at a Meeting held in Edmonton, Alberta (October 12-15, 1982). Summary of Discussions and Agreements Reached = Numero special sur le Reseau Scientifique Internationale pour le Nord cree a la reunion tenue a Edmonton, Alberta (du 12 au 15 octobre 1982). Resume des discussions et accords conclus.

    ERIC Educational Resources Information Center

    Communique, 1983

    1983-01-01

    Delegations from Canada, Finland, Greenland, Norway, Sweden, and the United States agreed to the establishment of a network for cooperation among individuals engaged in problems peculiar to the circumpolar North. The Northern Science Network, established within the Unesco Man and the Biosphere Program, consists of three themes: studies on the…

  3. D'Eichthal and Urbain's "Lettres sur la race noire et la race blanche": race, gender, and reconciliation after slave emancipation.

    PubMed

    Andrews, Naomi J

    2011-01-01

    This article is a close reading of Gustave D'Eichthal and Ishmayl Urbain's Lettres sur la race noire et la race blanche (1839), written during the decade prior to the "second" French emancipation in 1848. The article argues that the hierarchical gendering of race described in the letters is reflective of metropolitan concerns about potential for social disorder accompanying slave emancipation in the French colonies. In arguing for social reconciliation through interracial marriage and its offspring, the symbolically charged figure of the mulatto, the authors deployed gendered and familial language to describe a stable post-emancipation society.

  4. L’opinion des étudiants en médecine de Québec sur les punitions corporelles

    PubMed Central

    Labbé, Jean; Laflamme, Nathalie; Makosso-Kallyth, Sun

    2012-01-01

    OBJECTIF : L’objectif de la présente étude est de décrire l’opinion des étudiants en médecine de l’Université Laval sur le sujet controversé des punitions corporelles envers les enfants. MÉTHODOLOGIE : Un sondage a été réalisé auprès des étudiants en quatrième année de médecine de l’Université Laval pendant cinq années consécutives, soit de l’année scolaire 2006–2007 jusqu’à celle de 2010–2011 inclusivement, à l’occasion d’un séminaire portant sur la maltraitance envers les enfants. RÉSULTATS : Sur les 712 étudiants interrogés, 74 % étaient de sexe féminin et 91 % étaient âgés de moins de 30 ans. Concernant les punitions corporelles envers les enfants, 22 % des répondants s’y sont déclarés favorables. Plus de garçons que de filles se sont prononcés en faveur de cette pratique disciplinaire, soit 31 % des garçons par rapport à 18 % des filles respectivement (RC rajusté = 2,2, IC 95 % :1,4 à 3,4; p=0,0003). Près de 36 % des étudiants ayant eu des punitions corporelles y étaient favorables, comparativement à seulement 4 % de ceux qui n’avaient pas connu cette forme de discipline (RC rajusté = 16,5, IC 95 % :8,6 à 31,4; p<0,0001). Parmi ceux qui ont mentionné avoir été victimes d’abus physique, 25 % se sont déclarés en faveur de cette pratique, ce qui est similaire au 21 % observés chez ceux qui n’en ont pas été victimes (p=0,52). CONCLUSION : Alors que plusieurs organismes médicaux se sont prononcés contre l’utilisation des punitions corporelles, plus d’un futur médecin sur cinq à Québec se déclare favorable à cette méthode disciplinaire et pourrait influencer la conduite des parents en ce sens. PMID:24179417

  5. Scénarios dynamiques d'une fibre dopée erbium fonctionnant sur deux longueurs d'onde

    NASA Astrophysics Data System (ADS)

    Bérisson, W.; Besnard, P.; Ginovart, F.; Le Boudecl, P.; Sanchez, F.; Stéphan, G. M.

    2002-06-01

    Nous montrons la sensibilité à l'anisotropie de pompe des diagrammes de bifurcation d'une fibre dopée erbium fonctionnant sur deux longueurs d'onde. Un très bon accord entre les diagrammes de bifurcation expérimentaux et ceux obtenus théoriquement a été obtenu. De nouveaux types de bistabilités (3T-chaos et IT-chaos) sont mis en évidence pour ces systèmes.

  6. Evaluation du niveau de connaissance des patients sur la gestion du traitement par les antis vitamines K dans le service de cardiologie de Ouagadougou

    PubMed Central

    Samadoulougou, André; Temoua Naibe, Dangwé; Mandi, Germain; Yameogo, Relwendé Aristide; Kabore, Elisé; Millogo, Georges; Yameogo, Nobila Valentin; Kologo, Jonas Koudougou; Thiam/Tall, Anna; Toguyeni, Boubacar Jean Yves; Zabsonre, Patrice

    2014-01-01

    Introduction Les antivitamines K (AVK), traitement anticoagulant oral le plus largement prescrit, posent un réel problème de santé publique du fait de leur risque iatrogène. L'objectif de cette étude était de préciser le niveau de connaissance des patients sur la gestion de leur traitement par les AVK. Méthodes Il s'est agi d'une enquête transversale descriptive réalisée au CHU-Yalgado Ouédraogo, sur une période de 03 mois : du 1er mars au 31 mai 2012. Un questionnaire a été administré aux patients bénéficiant d'un traitement AVK depuis au moins un mois. Résultats Soixante-dix patients ont été inclus dans l'étude dont 30 hommes. L'âge moyen était de 49 ans ± 16 ans. Les cardiopathies et la maladie thromboembolique veineuse justifiant l'institution du traitement AVK étaient retrouvées respectivement dans 58,6% et 41,4% des cas. Le nom de l'AVK et la raison exacte du traitement étaient connus respectivement dans 91,4% et 67,1% des cas. Plus de la moitié des patients (68,6%) savaient que les AVK rendaient le sang plus fluide. Quarante-six patients (65,7%) citaient l'INR comme examen biologique de surveillance du traitement et seulement 28 patients (40%) connaissaient les valeurs cibles. La majorité des patients ne connaissait pas les risques encourus en cas de surdosage (72,8%) et de sous-dosage (71,4%). Une automédication par anti-inflammatoire non stéroïdien était signalée par 18 patients (25,7%). Les choux (74,3%) et la laitue (62,9%), aliments à consommer avec modération, étaient les plus cités. Conclusion Les connaissances des patients sur la gestion des AVK étaient fragmentaires et insuffisantes pour assurer la sécurité et l'efficacité du traitement. La création d'un programme d'éducation thérapeutique sur les AVK s'avère alors nécessaire. PMID:25870741

  7. Patient-Centered Communication for Discussing Oncotype DX Testing.

    PubMed

    Roberts, Megan C; Bryson, Amy; Weinberger, Morris; Dusetzina, Stacie B; Dinan, Michaela A; Reeder-Hayes, Katherine E; Wheeler, Stephanie B

    2016-05-27

    Oncotype DX testing (ODX), a tumor gene expression test, may improve breast cancer care, however, communicating results remains challenging. We identified patient-centered communication strategies/gaps for discussing ODX results. We applied a patient-centered communication framework to analyze qualitative interviews with oncologists about how they communicate about ODX with patients, using template analysis in Atlas.ti. Overall, providers discussed four patient-centered communication domains: exchanging information, assessing uncertainty, making decisions and cross-cutting themes. Providers did not report discussing emotional aspects of managing uncertainty, assessing decision-making preferences, and evaluating decisions. A patient-centered approach may be a model for communicating about tumor gene expression tests. PMID:27124287

  8. LANL Researcher Roger Wiens Discusses ChemCam

    SciTech Connect

    Wiens, Roger

    2012-02-15

    Discussion of the ChemCam instrument on the Curiosity Rover that occurred during the NASA press conference prior to launch of the Mars Science Laboratory. The ChemCam instrument was developed by Los Alamos National Laboratory and the French Space Institute. Los Alamos National Laboratory researcher Roger Wiens discusses the instrument on this video. ChemCam uses a laser to "zap" features of the Martian landscape and then uses a spectrometer to gather information about the composition of the sample. ChemCam will help the Curiosity Rover determine whether Mars is or was habitable. The Rover is expected to touch down on the Red Planet on August 5, 2012.

  9. Pathogenesis of Bacterial Vaginosis: Discussion of Current Hypotheses.

    PubMed

    Muzny, Christina A; Schwebke, Jane R

    2016-08-15

    In April 2015, the Division of Microbiology and Infectious Diseases of the National Institute of Allergy and Infectious Diseases hosted an experts technical consultation on bacterial vaginosis (BV), where data regarding controversies over the pathogenesis of BV were discussed. The discussion on the epidemiology and pathogenesis of BV is presented here, and several hypotheses on its pathogenesis are critiqued. Rigorous hypothesis-driven studies are needed to ultimately determine the cause of BV. This information is vital for the prevention and control of this important infection and its adverse public health consequences.

  10. In class and online: using discussion boards in teaching.

    PubMed

    Suler, John

    2004-08-01

    Discussion boards provide instructors a unique opportunity to extend their classrooms into cyberspace. This article offers some observations about student behavior in these online forums and practical suggestions for the instructor, including the creation of rules and structure for the online environment, factors influencing student participation, and strategies for facilitating discussion. Critical concepts for understanding the effective functioning of these online groups, such as confidentiality, the disinhibition effect, and the integration of the online and in-person settings, also are explored. PMID:15331026

  11. Discussing adolescent sexual health in African-American churches.

    PubMed

    Williams, Terrinieka T; Dodd, Darcy; Campbell, Bettina; Pichon, Latrice C; Griffith, Derek M

    2014-04-01

    This study describes the ways in which two African-American churches discuss adolescent sexual health topics. Six focus groups were conducted in two churches in Flint, Michigan, that reported no formal sexual health programming for their congregants. Three themes emerged to highlight the different perspectives about the role of churches in adolescent sexual decision-making and sexual health education: (1) churches as sources of sexual information, (2) churches as complex communities, and (3) recommendations for sexual education in churches. Participant responses suggest that churches can and should serve a resource for sexual health information. Implications for practice and research are discussed.

  12. LANL Researcher Roger Wiens Discusses ChemCam

    ScienceCinema

    Wiens, Roger

    2016-07-12

    Discussion of the ChemCam instrument on the Curiosity Rover that occurred during the NASA press conference prior to launch of the Mars Science Laboratory. The ChemCam instrument was developed by Los Alamos National Laboratory and the French Space Institute. Los Alamos National Laboratory researcher Roger Wiens discusses the instrument on this video. ChemCam uses a laser to "zap" features of the Martian landscape and then uses a spectrometer to gather information about the composition of the sample. ChemCam will help the Curiosity Rover determine whether Mars is or was habitable. The Rover is expected to touch down on the Red Planet on August 5, 2012.

  13. What Asexuality Contributes to the Same-Sex Marriage Discussion.

    PubMed

    Scherrer, Kristin S

    2010-01-01

    While same-sex marriage debates have captured public attention, it is but one component of a broader discussion regarding the role of marriage in a changing society. To inform this discussion, I draw on qualitative, Internet survey data from 102 self-identified asexual individuals. I find that asexual relationships are complicated and nuanced in ways that have implications for a GLBTQ political agenda, including same-sex marriage recognition. In addition, findings indicate that assumptions of sex and sexuality in relationships are problematic and that present language for describing relationships is limiting. Findings suggest a social justice agenda for marginalized sexualities should be broader in scope than same-sex marriage.

  14. (Discussion of plastic media blasting): Foreign trip report, 1988

    SciTech Connect

    Gat, U.

    1988-07-21

    The visit to MBB was to see and discuss the plastic media blasting equipment developed and manufactured as a cooperative effort by Schlick and MBB. The Germans emphasized a systematic approach and complete control over most parameters. The goal is to achieve conditions which do not cause damage to the aircraft. To arrive at the goal the air pressure that delivers the air to entrain the media, the flow rate of media, and the media itself are carefully and accurately controlled. Distance of nozzle and angle of blasting were systematically investigated. The wet (freon) cleanup system under development at Schlick was not discussed.

  15. [Tyson's glands. On eponymic and discussion in urology and dermatology].

    PubMed

    Moll, F H; Halling, T; Leissner, J; Fangerau, H

    2015-06-01

    The use of eponyms in scientific terminology and particularly in medical terminology has a long tradition but discussion often arises especially since the involvement of the protagonists in the National Socialist regime which led to strong controversies (e. g. Clara, Stieve, Reiter, Wegener). They are a component of cultural specialist memories and contribute to the conciseness of the nomenclature. For the specialization of urology a total list of eponyms in general use or an analysis of the use of eponyms does not exist. The eponym Tyson's glands is a good example of the tradition of eponyms in urology and the discussion about the related anatomical facts.

  16. [Tyson's glands. On eponymic and discussion in urology and dermatology].

    PubMed

    Moll, F H; Halling, T; Leissner, J; Fangerau, H

    2015-06-01

    The use of eponyms in scientific terminology and particularly in medical terminology has a long tradition but discussion often arises especially since the involvement of the protagonists in the National Socialist regime which led to strong controversies (e. g. Clara, Stieve, Reiter, Wegener). They are a component of cultural specialist memories and contribute to the conciseness of the nomenclature. For the specialization of urology a total list of eponyms in general use or an analysis of the use of eponyms does not exist. The eponym Tyson's glands is a good example of the tradition of eponyms in urology and the discussion about the related anatomical facts. PMID:26081821

  17. Pathogenesis of Bacterial Vaginosis: Discussion of Current Hypotheses.

    PubMed

    Muzny, Christina A; Schwebke, Jane R

    2016-08-15

    In April 2015, the Division of Microbiology and Infectious Diseases of the National Institute of Allergy and Infectious Diseases hosted an experts technical consultation on bacterial vaginosis (BV), where data regarding controversies over the pathogenesis of BV were discussed. The discussion on the epidemiology and pathogenesis of BV is presented here, and several hypotheses on its pathogenesis are critiqued. Rigorous hypothesis-driven studies are needed to ultimately determine the cause of BV. This information is vital for the prevention and control of this important infection and its adverse public health consequences. PMID:27449868

  18. How to make the most of the reflective discussion.

    PubMed

    Dean, Erin

    2016-06-01

    The Nursing and Midwifery Council's new process for re-registering nurses and midwives--revalidation--went live on April 1. Nurse managers will be expected to play a pivotal role in ensuring their staff are able to revalidate by acting as their reflective discussion partners and/or their confirmers. This article sets out the steps involved in reflective discussions and confirmation, along with the responsibilities of nurse managers involved. There is also a case study that offers tips from a nurse manager who has acted as confirmer on several occasions. PMID:27246431

  19. Why Can't We Discuss Intelligent Design?

    ERIC Educational Resources Information Center

    Turner, J. Scott

    2007-01-01

    While giving a presentation on his book about living things and the functions they perform ("The Tinkerer's Accomplice"), this author was faced with a heckler who asked intrusive "questions" and demanded "clarifications" that were intended not to illuminate the discussion, but rather to disrupt and distract from the presentation. The author…

  20. Improving Argumentation through Goal Instructions in Asynchronous Online Discussions

    ERIC Educational Resources Information Center

    Prudchenko, Yekaterina

    2014-01-01

    Argumentation incorporated into class discussions can improve students' problem solving skills and enhance their epistemic and conceptual understanding. Research indicates students sometimes need scaffolding such as goal instructions to improve their argumentation skills. This study examined the effectiveness of different types of goal…