Science.gov

Sample records for 25th anniversary rejuvenation

  1. 25th anniversary. Population education.

    PubMed

    Tagle Ra

    1998-01-01

    The Population Education Program's (POPED) main areas of concern are family life and responsible parenthood; gender and development; population and reproductive health; and population, resources and environment, and sustainable development. POPED celebrated its 25th year of existence during October 6-8, 1997, at a National Convention in Davao City organized by the Department of Education, Culture, and Sports (DECS) and its governmental partner agencies, including the Philippine Population Commission (POPCOM), the Department of Health (DOH), and others. The event was held to update POPED stakeholders on current trends and developments in the program and to strengthen existing partnerships between government organizations and nongovernmental organizations (NGOs). The convention also allowed the sharing of 25 years of experience, a chance to generate recommendations for improving the program, and the opportunity to seek greater commitment to POPED's cause from all concerned parties. Rapid population growth and its consequences, integrating family planning into all fields of study, core messages, and the future lifestyle of Filipino youths are discussed.

  2. Apollo 11 25th Anniversary logo

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This Official NASA commemorative logo marks the 25th anniversary of the first lunar landing. The design incorporates an eagle, from the original Apoll 11 crew insignia, descending toward the lunar surface with an olive branch, symbolizing America's peaceful mission in space. Alternative Headquarters number is 93-HC-312 or 93-H-336.

  3. Apollo 11 25th Anniversary logo

    NASA Image and Video Library

    1993-08-03

    This official NASA commemorative logo marks the 25th anniversary of the first lunar landing. The design incorporates an eagle, from the original Apoll 11 crew insignia, descending toward the lunar surface with an olive branch, symbolizing America's peaceful mission in space. Alternative Headquarters number is 93-HC-312 or 93-H-336.

  4. Hubble 25th Anniversary: NASA Social at Goddard

    NASA Image and Video Library

    NASA's Hubble Space Telescope celebrated its 25th anniversary on April 24, 2015. To mark the occasion, NASA's Goddard Space Flight Center in Greenbelt, Maryland -- home of Hubble operations -- host...

  5. 25th anniversary of the Gagarin Cosmonaut Training Center

    NASA Technical Reports Server (NTRS)

    Goreglyad, I.; Shonin, G.

    1985-01-01

    Interviews with retired Major General of Aviation L. Goreglyad and pilot-cosmonaut with the 25th anniversary of the establishment of the Gagarin Cosmonaut Training Center. Major-General Goreglyad, one of the Center's founders, tells of its development. Major General Shonin, one of the first cosmonauts to train there, tells of the tests and procedures leading to his acceptance as a trainee.

  6. Army Medical Department Lessons Learned Program marks 25th anniversary.

    PubMed

    Cannon, David W; McCollum, Jeffery

    2011-11-01

    The year 2010 marked the 25th anniversary of the Center for Army Lessons Learned (CALL) as well as the Army Medical Department (AMEDD) Center and School's Lessons Learned Division. In the aftermath of Operation Urgent Fury in 1983, the Army recognized the need to create an organization whose sole purpose was to collect, review, and analyze lessons learned and created the CALL in 1985 at Fort Leavenworth, Kansas. The AMEDD followed suit and established the Medical Information System/AMEDD Lessons Learned office under the Directorate of Evaluation and Standardization to research and compile lessons learned as the AMEDD's point of contact for the CALL program. Over these past 25 years the AMEDD Center and School Lessons Learned program evolved and underwent organizational realignments, but the overall mission continues to promote changes either directly or indirectly in the AMEDD's Doctrine, Organizations, Training, Leader Development, Materiel, Personnel and Facilities domains and capabilities to provide combat health service support on the battlefield.

  7. 76 FR 67799 - Pricing for the American Eagle 25th Anniversary Silver Coin Set

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF THE TREASURY United States Mint Pricing for the American Eagle 25th Anniversary Silver Coin Set AGENCY: United States... price of the American Eagle 25th Anniversary Silver Coin Set. The coin set will be offered for sale at...

  8. The discovery of the prokaryotic cytoskeleton: 25th anniversary.

    PubMed

    Erickson, Harold P

    2017-02-01

    The year 2017 marks the 25th anniversary of the discovery of homologues of tubulin and actin in prokaryotes. Before 1992, it was largely accepted that tubulin and actin were unique to eukaryotes. Then three laboratories independently discovered that FtsZ, a protein already known as a key player in bacterial cytokinesis, had the "tubulin signature sequence" present in all α-, β-, and γ-tubulins. That same year, three candidates for bacterial actins were discovered in silico. X-ray crystal structures have since confirmed multiple bacterial proteins to be homologues of eukaryotic tubulin and actin. Tubulin and actin were apparently derived from bacterial precursors that had already evolved a wide range of cytoskeletal functions. © 2017 Erickson. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  9. National Center for Biotechnology Information Celebrates 25th Anniversary | NIH MedlinePlus the Magazine

    MedlinePlus

    ... page please turn JavaScript on. National Center for Biotechnology Information Celebrates 25th Anniversary Past Issues / Winter 2014 ... Photo courtesy of NLM The National Center for Biotechnology Information (NCBI), a component of NLM, celebrated its ...

  10. Symposium commemorating the 25th anniversary of the discovery of mendelevium

    SciTech Connect

    Seaborg, G.T.

    1980-01-01

    The Symposium honoring the 25th Anniversary of the discovery of mendelevium was held at the Lawrence Berkeley Laboratory on March 28, 1980. The following three papers were presented: Chemical Properties of Mendelevium; Nuclear Properties of Mendelevium; and Radioactive Decay of Md Isotopes. Besides these papers there were introductory remarks, reminiscences, and concluding remarks.

  11. Explore@NASAGoddard celebrates the 25th anniversary of the launc

    NASA Image and Video Library

    2015-09-26

    Explore@NASAGoddard celebrates the 25th anniversary of the launch of the Hubble Space Telescope. All areas of Goddard’s research – Earth science, heliophysics, planetary science, astrophysics, and engineering and technology – will be presented, as each discipline plays a critical part in NASA's ongoing journey to reach new heights.

  12. Alumni of High School Internship Program Return for 25th Anniversary to Inspire Current Students | Poster

    Cancer.gov

    The Building 549 auditorium is often packed with high school interns eager to hear a scientific lecture. On April 22, however, the room swelled with interns spanning a wider age range. At the 25th Werner H. Kirsten Student Intern Program (WHK SIP) Anniversary Symposium, incoming, current, and former interns gathered to celebrate the program, which has provided biomedical research experience for local high school seniors.

  13. Alumni of High School Internship Program Return for 25th Anniversary to Inspire Current Students | Poster

    Cancer.gov

    The Building 549 auditorium is often packed with high school interns eager to hear a scientific lecture. On April 22, however, the room swelled with interns spanning a wider age range. At the 25th Werner H. Kirsten Student Intern Program (WHK SIP) Anniversary Symposium, incoming, current, and former interns gathered to celebrate the program, which has provided biomedical research experience for local high school seniors.

  14. Hubble’s 25th Anniversary: A Quarter-Century of Discovery and Inspiration

    NASA Astrophysics Data System (ADS)

    Straughn, Amber; Jirdeh, Hussein

    2015-01-01

    April 24, 2015 marks the 25th anniversary of the launch of the Hubble Space Telescope. In its quarter-century in orbit, the Hubble Space Telescope has transformed the way we understand the Universe, helped us find our place among the stars, and paved the way to incredible advancements in science and technology. NASA and ESA, including STScI and partners, will use the 25th anniversary of Hubble's launch as a unique opportunity to communicate to the widest possible audience the significance of the past quarter-century of discovery with the Hubble Space Telescope and to highlight that Hubble will continue to produce groundbreaking science results. We will enhance public understanding of Hubble's many contributions to the scientific world, and will capitalize on Hubble's cultural popularity by emphasizing its' successor, the James Webb Space Telescope. This poster highlights many of the upcoming opportunities to join in the anniversary activities, both in-person and online. Find out more at hubble25th.org and follow #Hubble25 on social media.

  15. [The Citizen Constitution and the 25th anniversary of the Brazilian Unified National Health System (SUS)].

    PubMed

    Paim, Jairnilson Silva

    2013-10-01

    This article, celebrating the 25th anniversary of Brazil's 1988 Constitution, aims to review the country's social policy development, discuss political projects, and analyze challenges for the sustainability of the Unified National Health System (SUS). Based on public policymaking studies, the article revisits the origins of liberal social policy, focused on social assistance, and analyzes the hegemony of U.S. policies targeting poverty and their repercussions for universal policies. After identifying the formulation of political projects in Brazil's democratic transition, it discusses their implications during the various Administrations since 1988, along with the difficulties faced by the National Health System. The article concludes that the political forces occupying government in the last two decades have failed to present a project for the country on the same level as those who drafted the Citizen Constitution.

  16. The Prospects for Educational Planning. A Workshop Organised by IIEP on the Occasion of Its 25th Anniversary.

    ERIC Educational Resources Information Center

    Caillods, Francoise, Ed.

    In late 1988, on the occasion of its 25th anniversary celebration, the International Institute for Educational Planning organized an international workshop to review the major problems faced by education today and to consider the future of educational planning worldwide. The workshop brought together researchers, planners, and specialists from all…

  17. Reflections on the 25th Anniversary of the U.S. Supreme Court's Decision in Board of Education v. Rowley

    ERIC Educational Resources Information Center

    Yell, Mitchell L.; Katsiyannis, Antonis; Hazelkorn, Michael

    2007-01-01

    June 22, 2007, was the 25th anniversary of the U.S. Supreme Court's decision in Board of Education of the Hendrick Hudson Central School District v. Rowley (hereafter Rowley; 1982). In Rowley, the Supreme Court interpreted congressional intent in requiring that public schools provide a free appropriate public education (FAPE) to students with…

  18. 25th anniversary article: Chemically modified/doped carbon nanotubes & graphene for optimized nanostructures & nanodevices.

    PubMed

    Maiti, Uday Narayan; Lee, Won Jun; Lee, Ju Min; Oh, Youngtak; Kim, Ju Young; Kim, Ji Eun; Shim, Jongwon; Han, Tae Hee; Kim, Sang Ouk

    2014-01-08

    Outstanding pristine properties of carbon nanotubes and graphene have limited the scope for real-life applications without precise controllability of the material structures and properties. This invited article to celebrate the 25th anniversary of Advanced Materials reviews the current research status in the chemical modification/doping of carbon nanotubes and graphene and their relevant applications with optimized structures and properties. A broad aspect of specific correlations between chemical modification/doping schemes of the graphitic carbons with their novel tunable material properties is summarized. An overview of the practical benefits from chemical modification/doping, including the controllability of electronic energy level, charge carrier density, surface energy and surface reactivity for diverse advanced applications is presented, namely flexible electronics/optoelectronics, energy conversion/storage, nanocomposites, and environmental remediation, with a particular emphasis on their optimized interfacial structures and properties. Future research direction is also proposed to surpass existing technological bottlenecks and realize idealized graphitic carbon applications. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Marshall Space Flight Center 1960-1985: 25th anniversary report

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The Marshall Space FLight Center marks its 25th aniversary with a record of notable achievements. These accomplishments are the essence of the Marshall Center's history. Behind the scenes of the space launches and missions, however, lies the story of challenges faced and problems solved. The highlights of that story are presented. The story is organized not as a straight chronology but as three parallel reviews of the major assignments: propulsion systems and launch vehicles, space science research and technology, and manned space systems. The general goals were to reach space, to know and understand the space environment, and to inhabit and utilize space for the benefit of mankind. Also included is a chronology of major events, presented as a fold-out chart for ready reference.

  20. Children's Rights and School Psychology: An Introduction to the Multiple Journal Series Honoring the 25th Anniversary of the United Nations Convention on the Rights of the Child

    ERIC Educational Resources Information Center

    Mcloughlin, Caven S.; Hart, Stuart N.

    2014-01-01

    This year, 2014, is the 25th anniversary of the United Nations Convention on the Rights of the Child--the world's "positive ideology" and its clearest statement of commitments to and respect and aspirations for the dignity of the child. To commemorate this landmark, a program of articles by respected experts has been organized to advance…

  1. Children's Rights and School Psychology: An Introduction to the Multiple Journal Series Honoring the 25th Anniversary of the United Nations Convention on the Rights of the Child

    ERIC Educational Resources Information Center

    Mcloughlin, Caven S.; Hart, Stuart N.

    2014-01-01

    This year, 2014, is the 25th anniversary of the United Nations Convention on the Rights of the Child--the world's "positive ideology" and its clearest statement of commitments to and respect and aspirations for the dignity of the child. To commemorate this landmark, a program of articles by respected experts has been organized to advance…

  2. Informing Policy and Practice in Australia's Vocational Education and Training Sector: Reflections and Futures. Proceedings of the 25th Anniversary Forum of the National Centre for Vocational Education Research (Adelaide, South Australia, Australia, March 21, 2007)

    ERIC Educational Resources Information Center

    Curtin, Penelope, Ed.; Loveder, Phil, Ed.

    2007-01-01

    To mark the occasion of its 25th anniversary, the National Centre for Vocational Education Research (NCVER) brought together policy, industry and academic leaders to reflect on the role that research and statistics have played in the development of Australia's vocational education and training (VET) sector. This publication includes the original…

  3. Proceedings of the Anniversary Meeting (25th, Toronto, December 28-29, 1972). Industrial Relations Research Association Series. Index of IRRA Publications 1966-1972.

    ERIC Educational Resources Information Center

    Somers, Gerald G., Ed.

    Papers presented at the 25th meeting of the Industrial Relations Research Association (IRAA) covered issues that are central to industrial relations in North America. Papers and discussions dealt with these major issues: (1) Prices and Income Policy: Comparative Aspects, (2) Dispute Settlement in the Public Sector, (3) Manpower Policies in Canada…

  4. 25th anniversary article: Ion exchange in colloidal nanocrystals.

    PubMed

    Gupta, Shuchi; Kershaw, Stephen V; Rogach, Andrey L

    2013-12-23

    We review the progress in ion exchange in a variety of nanocrystal structures from the earliest accounts dating back over two decades ago to the present day. In recent years the number of groups using this method to form otherwise difficult or inaccessible nanoparticle shapes and morphologies has increased considerably and the field has experienced a resurgence of interest. Whilst most of the early work on cation exchange centered on II-VI materials, the methodology has been expanded to cover a far broader range of semiconductor nanocrystals including low toxicity I-III-VI materials and the much less facile III-V materials. The extent of exchange can be controlled leading to lightly doped nanoparticles, alloys, core-shells, segmented rods and dots-in-rods. Progress has been driven by a better understanding of the underlying principles of the exchange process - from thermodynamic factors (differences in cation solubilities); the interactions between ions and transfer agents (solvents, ligands, anions, co-dopants); ionic in-diffusion mechanisms and kinetics. More recent availability of very detailed electron microscopy coupled with image reconstruction techniques has been a valuable tool to investigate the resulting heterostructures and internal interfaces. We start by surveying the range of synthetic approaches most often used to carry out ion exchange, mainly focusing on cation replacement strategies, and then describe the rich variety of nanostructures these techniques can bring forth. We also describe some of the principles that are used to establish the relative ease of exchange and to systematically improve the process where the basic energetics are less favorable. To help further the understanding of the underlying fundamentals we have gathered together useful data from the literature on solubilities, cation and anion hardness, ligand and solvent Lewis acid or base strengths for a wide range of chemical species generally used. We offer a perspective on the outlook for the field in terms of the emerging applications and the ion exchange derived materials that will enable them. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Selected Papers, ASTD 25th Anniversary National Conference.

    ERIC Educational Resources Information Center

    American Society for Training and Development, Madison, WI.

    Taken from the annual conference (May 12-16, 1969) of the American Society for Training and Development, these papers concentrate on sociological and related trends affecting manpower development and utilization. Such topics as new training and educational resources for industrial trainers, current social change and upheaval on and off college…

  6. PAX6: 25th anniversary and more to learn.

    PubMed

    Cvekl, Ales; Callaerts, Patrick

    2016-04-25

    The DNA-binding transcription factor PAX6 was cloned 25 years ago by multiple teams pursuing identification of human and mouse eye disease causing genes, cloning vertebrate homologues of pattern-forming regulatory genes identified in Drosophila, or abundant eye-specific transcripts. Since its discovery in 1991, genetic, cellular, molecular and evolutionary studies on Pax6 mushroomed in the mid 1990s leading to the transformative thinking regarding the genetic program orchestrating both early and late stages of eye morphogenesis as well as the origin and evolution of diverse visual systems. Since Pax6 is also expressed outside of the eye, namely in the central nervous system and pancreas, a number of important insights into the development and function of these organs have been amassed. In most recent years, genome-wide technologies utilizing massively parallel DNA sequencing have begun to provide unbiased insights into the regulatory hierarchies of specification, determination and differentiation of ocular cells and neurogenesis in general. This review is focused on major advancements in studies on mammalian eye development driven by studies of Pax6 genes in model organisms and future challenges to harness the technology-driven opportunities to reconstruct, step-by-step, the transition from naïve ectoderm, neuroepithelium and periocular mesenchyme/neural crest cells into the three-dimensional architecture of the eye.

  7. 25th anniversary article: Engineering hydrogels for biofabrication.

    PubMed

    Malda, Jos; Visser, Jetze; Melchels, Ferry P; Jüngst, Tomasz; Hennink, Wim E; Dhert, Wouter J A; Groll, Jürgen; Hutmacher, Dietmar W

    2013-09-25

    With advances in tissue engineering, the possibility of regenerating injured tissue or failing organs has become a realistic prospect for the first time in medical history. Tissue engineering - the combination of bioactive materials with cells to generate engineered constructs that functionally replace lost and/or damaged tissue - is a major strategy to achieve this goal. One facet of tissue engineering is biofabrication, where three-dimensional tissue-like structures composed of biomaterials and cells in a single manufacturing procedure are generated. Cell-laden hydrogels are commonly used in biofabrication and are termed "bioinks". Hydrogels are particularly attractive for biofabrication as they recapitulate several features of the natural extracellular matrix and allow cell encapsulation in a highly hydrated mechanically supportive three-dimensional environment. Additionally, they allow for efficient and homogeneous cell seeding, can provide biologically-relevant chemical and physical signals, and can be formed in various shapes and biomechanical characteristics. However, despite the progress made in modifying hydrogels for enhanced bioactivation, cell survival and tissue formation, little attention has so far been paid to optimize hydrogels for the physico-chemical demands of the biofabrication process. The resulting lack of hydrogel bioinks have been identified as one major hurdle for a more rapid progress of the field. In this review we summarize and focus on the deposition process, the parameters and demands of hydrogels in biofabrication, with special attention to robotic dispensing as an approach that generates constructs of clinically relevant dimensions. We aim to highlight this current lack of effectual hydrogels within biofabrication and initiate new ideas and developments in the design and tailoring of hydrogels. The successful development of a "printable" hydrogel that supports cell adhesion, migration, and differentiation will significantly advance this exciting and promising approach for tissue engineering. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Naval Training Device Center 25th Anniversary Commemorative Technical Journal.

    ERIC Educational Resources Information Center

    Amico, G. Vincent; Regan, James J.

    Both the technical history of training devices and the issues which currently confront their design and use are discussed by a group of distinguished scientists and engineers. A blend of human factors and engineering paper reflects the twin thrusts that make up the educational tools that are training device systems. (Author)

  9. 25th Anniversary Article: Supramolecular Materials for Regenerative Medicine

    PubMed Central

    Boekhoven, Job

    2014-01-01

    In supramolecular materials, molecular building blocks are designed to interact with one another via non-covalent interactions in order to create function. This offers the opportunity to create structures similar to those found in living systems that combine order and dynamics through the reversibility of intermolecular bonds. For regenerative medicine there is a great need to develop materials that signal cells effectively, deliver or bind bioactive agents in vivo at controlled rates, have highly tunable mechanical properties, but at the same time, can biodegrade safely and rapidly after fulfilling their function. These requirements make supramolecular materials a great platform to develop regenerative therapies. This review illustrates the emerging science of these materials and their use in a number of applications for regenerative medicine. PMID:24496667

  10. Buildings 7 & 29. Explore@NASAGoddard celebrates the 25th annive

    NASA Image and Video Library

    2015-09-26

    Buildings 7 & 29. Explore@NASAGoddard celebrates the 25th anniversary of the launch of the Hubble Space Telescope. All areas of Goddard’s research – Earth science, heliophysics, planetary science, astrophysics, and engineering and technology – will be presented, as each discipline plays a critical part in NASA's ongoing journey to reach new heights.

  11. Buildings 7 & 29. Explore@NASAGoddard celebrates the 25th annive

    NASA Image and Video Library

    2015-09-25

    Buildings 7 & 29. Explore@NASAGoddard celebrates the 25th anniversary of the launch of the Hubble Space Telescope. All areas of Goddard’s research – Earth science, heliophysics, planetary science, astrophysics, and engineering and technology – will be presented, as each discipline plays a critical part in NASA's ongoing journey to reach new heights.

  12. 25th Texas Symposium on Relativistic Astrophysics

    NASA Astrophysics Data System (ADS)

    Rieger, Frank M.; van Eldik, Christopher; Hofmann, Werner

    The 25th Texas Symposium on Relativistic Astrophysics (TEXAS 2010) was held in Heidelberg, Germany, during December, 6-10, 2010. More than 350 astrophysicists attended a very interesting meeting, designed to exchange ideas and results, and to discuss future directions in Relativistic Astrophysics. A wide range of scientific results were discussed in about 100 oral and about 200 poster contributions during nine parallel afternoon sessions and one highlight evening session. Further information, including the full program, can be found on the conference webpage: http://www.mpi-hd.mpg.de/texas2010/. The papers published here in these proceedings represent the contributions accepted for the parallel sessions and the main poster session at TEXAS 2010.

  13. EDITORIAL: Inverse Problems' 25th year of publication Inverse Problems' 25th year of publication

    NASA Astrophysics Data System (ADS)

    2008-01-01

    2009 is Inverse Problems' 25th year of publication. In this quarter-century, the journal has established itself as the premier publication venue for inverse problems research. It has matured from its beginnings as a niche journal serving the emerging field of inverse and ill-posed problems to a monthly publication in 2009 covering all aspects of a well-established, vibrant and still-expanding subject. Along with its core readership of pure and applied mathematicians and physicists, Inverse Problems has become widely known across a broad range of researchers in areas such as geophysics, optics, radar, acoustics, communication theory, signal processing and medical imaging, amongst others. The journal's appeal to the inverse problems community and those researchers from the varied fields that encounter such problems can be attributed to our commitment to publishing only the very best papers, and to offering unique services to the community. Besides our regular research papers, which average a remarkably short five months from submission to electronic publication, we regularly publish heavily cited topical review papers and topic-specific special sections, which first appeared in 2004. These highly-downloaded invited articles focus on the latest developments and hot topics in all areas of inverse problems. No other journal in the field offers these features. I am very pleased to take Inverse Problems into its 25th year as Editor-in-Chief. The journal has an impressive tradition of scholarship, established at its inception by the founder and first Editor-in-Chief, Professor Pierre Sabatier. Professor Sabatier envisioned the journal in 1985 as providing a medium for publication of exemplary research in our intrinsically interdisciplinary field. I am glad to say that the support of our authors, readers, referees, Editors-in-Chief, Editorial Boards and Advisory Panels over the years, has resulted in Inverse Problems becoming the top publication in this field, publishing

  14. 25th Annual Vascular Surgery Seminar and Meeting of the Society for Military Vascular Surgery.

    PubMed

    Rich, N M

    1998-12-01

    The 25th Annual (Silver Anniversary) Vascular Surgery Seminar and Meeting of the Society for Military Vascular Surgery was held in the Jay P. Sanford Auditorium at the F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences (USUHS), 4-6 December 1997. This highly successful exchange included active duty military surgeons, military surgeons in the reserves, retired military officers continuing second careers in civilian vascular surgery, distinguished visiting professors from the United States and abroad, International Guest Scholars, USUHS Faculty as well as colleagues and friends. The emphasis continued to be directed to ensuring that military vascular surgery remains current, recognizing the rich heritage of contributions to vascular surgery in general that have come from surgeons serving on battlefields around the world, particularly in this 20th century.

  15. Vaginal rejuvenation: current perspectives

    PubMed Central

    Barbara, Giussy; Facchin, Federica; Buggio, Laura; Alberico, Daniela; Frattaruolo, Maria Pina; Kustermann, Alessandra

    2017-01-01

    Female genital cosmetic surgery includes several procedures aimed at reaching better female genital appearance and/or improved sexual functioning. Among these procedures, vaginal rejuvenation is considered as one of the most controversial genital cosmetic surgical interventions and involves a range of surgical procedures performed by gynecologists or plastic surgeons to decrease the average diameter of the vagina, mainly for sexual reasons. In this narrative review, vaginal rejuvenation outcomes are examined in order to clarify the current scenario of the different vaginal rejuvenation techniques, as well as their effectiveness and associated complications. Psychological and ethical issues linked to these procedures are also addressed. PMID:28860864

  16. Newspapers on Microfilm. Catalog and Price List 1971, 25th Anniversary Edition.

    ERIC Educational Resources Information Center

    1971

    Over 5500 current and backfile titles of American, foreign, and Black community newspapers that may be purchased on 35mm. roll microfilm are indexed in this catalog. Historical annotations are provided for selected American, Asian, and other foreign newspapers as well as for collections which focus on areas of special interest: early America, the…

  17. Trek across Maine 25th anniversary: a public health strategy to increase physical activity.

    PubMed

    Martin, Sarah Levin; Martin, Maurice; Perry, Tess; Harris, Jessica Maureen

    2013-09-01

    Could an annual event be an effective strategy to improve physical activity? Based on 25 years of data, we argue that it could be. Although there are eight recommended strategies to promote physical activity in the Community Guide, there is insufficient evidence for six others. Qualitative data collected from Trek Across Maine participants and other cause-specific events suggests that goal setting (i.e., individually adapted health behavior change) and family-based social support may be key factors in helping individuals become more physically active.

  18. A resolution honoring the Blackstone Valley Tourism Council on the celebration of its 25th anniversary.

    THOMAS, 111th Congress

    Sen. Whitehouse, Sheldon [D-RI

    2010-03-24

    Senate - 04/14/2010 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  19. 25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine

    PubMed Central

    Annabi, Nasim; Tamayol, Ali; Uquillas, Jorge Alfredo; Akbari, Mohsen; Bertassoni, Luiz E.; Cha, Chaenyung; Camci-Unal, Gulden; Dokmeci, Mehmet R.

    2014-01-01

    Hydrogels are hydrophilic polymer-based materials with high water content and physical characteristics that resemble the native extracellular matrix. Because of their remarkable properties, hydrogel systems are used for a wide range of biomedical applications, such as three-dimensional (3D) matrices for tissue engineering, drug-delivery vehicles, composite biomaterials, and as injectable fillers in minimally invasive surgeries. In addition, the rational design of hydrogels with controlled physical and biological properties can be used to modulate cellular functionality and tissue morphogenesis. Here, the development of advanced hydrogels with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light-sensitive, composite, and shape-memory hydrogels. Emerging technologies developed over the past decade to control hydrogel architecture are also discussed and a number of potential applications and challenges in the utilization of hydrogels in regenerative medicine are reviewed. It is anticipated that the continued development of sophisticated hydrogels will result in clinical applications that will improve patient care and quality of life. PMID:24741694

  20. The Hawaii Undersea Research Laboratory's 25th Anniversary Expedition to the South Pacific

    NASA Astrophysics Data System (ADS)

    Smith, J. R.; Wiltshire, J. C.; Malahoff, A.

    2005-12-01

    The Hawaii Undersea Research Laboratory (HURL) was established by NOAA at the University of Hawaii 25 years ago as part of its National Undersea Research Program. HURL's mission is to study deep water marine processes in the Pacific Ocean through a competitive proposal and review process. The dual Pisces IV and Pisces V 2000-meter manned submersibles, an RCV-150 1000-meter ROV, and multibeam equipped support ship R/V Ka'imikai-o-Kanaloa ( KoK) were largely acquired from the petroleum industry then adapted and upgraded to carry out cutting edge scientific expeditions. These studies range from active submarine volcanoes, delicate precious coral gardens, endangered marine mammal and fisheries management, to engineering surveys and deployment of observatory systems. HURL successfully completed a major 5-month expedition to the South Pacific during March-August 2005, working in the waters of New Zealand, Tonga, American Samoa, and the U.S. Line Islands covering a distance of nearly 14,500 nautical miles. This mission was significant in both the scientific merit and scope of operations, consisting of 8 different cruise legs at 21 study sites, with 12 chief and co-chief scientists, 58 total science team participants, and completing 61 out of 56 scheduled Pisces science dives, 17 ROV dives, 5 multibeam survey areas, 6 CTD rosette deployments, and 7 instrument mooring recoveries. The $3.5 million expedition was funded by an international partnership with New Zealand agencies (GNS & NIWA) and the University of Kiel in Germany along with the NOAA Office of Exploration and National Undersea Research Program. While most of the individual cruise legs focused on active submarine volcanoes of the Tonga-Kermadec Islands Arc and the Samoan hot spot chain with their hydrothermal systems and associated biological communities, others concentrated on marine protected areas including those of American Samoa and the remote atolls of the Line Islands of the Central Pacific. These studies included biological habitat mapping, climate change from dating of precious coral growth rings, ecological inventory assessments, and the marine archeology and impact from a grounded vessel. An overview of the latter portion of the voyage will be presented, along with the general capabilities of the HURL systems, and how they may be utilized by others employing the international collaborative model for extended missions to remote locations in the pursuit of deep submergence science.

  1. 25th anniversary article: ordered polymer structures for the engineering of photons and phonons.

    PubMed

    Lee, Jae-Hwang; Koh, Cheong Yang; Singer, Jonathan P; Jeon, Seog-Jin; Maldovan, Martin; Stein, Ori; Thomas, Edwin L

    2014-01-01

    The engineering of optical and acoustic material functionalities via construction of ordered local and global architectures on various length scales commensurate with and well below the characteristic length scales of photons and phonons in the material is an indispensable and powerful means to develop novel materials. In the current mature status of photonics, polymers hold a pivotal role in various application areas such as light-emission, sensing, energy, and displays, with exclusive advantages despite their relatively low dielectric constants. Moreover, in the nascent field of phononics, polymers are expected to be a superior material platform due to the ability for readily fabricated complex polymer structures possessing a wide range of mechanical behaviors, complete phononic bandgaps, and resonant architectures. In this review, polymer-centric photonic and phononic crystals and metamaterials are highlighted, and basic concepts, fabrication techniques, selected functional polymers, applications, and emerging ideas are introduced. © 2013 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  2. Cryogenian Snowball Earth: a 25th anniversary assessment of models and data

    NASA Astrophysics Data System (ADS)

    Hoffman, P. F.

    2014-12-01

    In 1989, Joe Kirschvink applied a nascent planetary climate theory—the self-reversing ice-albedo instability—to Neoproterozoic geology, citing paleomagnetic evidence that ancient Australian glaciers reached tidewater near the paleo-equator. He attributed the "snowball Earth" to a unique preponderance of low-latitude continents, and inferred that complex life including metazoa were spawned in the nutrient-rich glacial aftermath. There have been major advances in models and data since 1989, and gratifying convergences between them. In models, frozen oceans coexist with dynamic ice sheets, as demanded by geological data. Geochronological data show that snowball glaciations were prolonged and their terminations globally synchronous, as required by geochemical models for snowball deglaciation. In models, zonal average sources and sinks of water vapor are reversed in snowball atmospheres relative to climate states with ice lines (at low or high-latitude). Ice-covered oceans are well mixed, by true thermohaline meridional overturning and related jets, with implications for data linking iconic snowball iron-formations with silled basins. Triple oxygen isotope data from sulfate robustly supports model predictions of atmospheric CO2 required for snowball deglaciation, while promising results have been obtained from a variety of pH, weathering, productivity and redox sensitive proxies. The known first appearances of sponge biomarkers and metazoan embryos bracket the terminal Cryogenian snowball glaciation. Existing model-data conflicts are good targets for future research. Boron isotopes in syndeglacial cap dolomites consistently imply catastrophic ocean acidification upon deglaciation, while models suggest that the existence of cap dolomites implies that seawater acidified gradually and was buffered by the dissolution of carbonate, delivered by glaciers. Above all, the newly emerging Cryogenian chronology (highlighted in this session) presents new puzzles. Two low-latitude glaciations of grossly unequal longevity occurred in rapid succession. The Sturtian was 55-60 Myr long, followed a 109-yr glacial hiatus, and was distinguished by Fe2O3-rich sedimentary deposits; the Marinoan was 5-20 Myr long, followed a 107-yr glacial hiatus, and was distinguished by BaSO4-rich cap dolomite.

  3. 25th anniversary article: organic field-effect transistors: the path beyond amorphous silicon.

    PubMed

    Sirringhaus, Henning

    2014-03-05

    Over the past 25 years, organic field-effect transistors (OFETs) have witnessed impressive improvements in materials performance by 3-4 orders of magnitude, and many of the key materials discoveries have been published in Advanced Materials. This includes some of the most recent demonstrations of organic field-effect transistors with performance that clearly exceeds that of benchmark amorphous silicon-based devices. In this article, state-of-the-art in OFETs are reviewed in light of requirements for demanding future applications, in particular active-matrix addressing for flexible organic light-emitting diode (OLED) displays. An overview is provided over both small molecule and conjugated polymer materials for which field-effect mobilities exceeding > 1 cm(2) V(-1) s(-1) have been reported. Current understanding is also reviewed of their charge transport physics that allows reaching such unexpectedly high mobilities in these weakly van der Waals bonded and structurally comparatively disordered materials with a view towards understanding the potential for further improvement in performance in the future. © 2014 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. 25th anniversary article: Rise to power--OPV-based solar parks.

    PubMed

    Krebs, Frederik C; Espinosa, Nieves; Hösel, Markus; Søndergaard, Roar R; Jørgensen, Mikkel

    2014-01-08

    A solar park based on polymer solar cells is described and analyzed with respect to performance, practicality, installation speed, and energy payback time. It is found that a high voltage installation where solar cells are all printed in series enables an installation rate in Watts installed per minute that far exceed any other PV technology in existence. The energy payback time for the practical installation of polymer solar cell foil on a wooden 250 square meter platform in its present form is 277 days when operated in Denmark and 180 days when operated in southern Spain. The installation and de-installation rate is above 100 m min⁻¹, which, with the present performance and web width, implies installation of >200 W min⁻¹. In comparison, this also exceeds the overall manufacturing speed of the polymer solar cell foil with a width of 305 mm which is currently 1 m min⁻¹ for complete encapsulated and tested foil. It is also significant that simultaneous installation and de-installation which enables efficient schemes for decommissioning and recycling is possible. It is highlighted where research efforts should most rationally be invested in order to make grid electricity from OPV a reality (and it is within reach).

  5. A Quarter Century of Turmoil: School Finance in California on the 25th Anniversary of "Serrano."

    ERIC Educational Resources Information Center

    Picus, Lawrence O.

    1997-01-01

    Explains problems with complex system of educational finance in California. Addresses issues such as diversity, per pupil expenditure, and equity at district and school level; problems with special education, pupil transportation, supplemental grants, and "mega-item;" and brief history of California's school financing--including Serrano…

  6. Cartography and Connectomes Perspective article for Neuron 25th Anniversary Issue

    PubMed Central

    Van Essen, David C.

    2013-01-01

    The past 25 years have seen great progress in parcellating the cerebral cortex into a mosaic of many distinct areas in mice, monkeys, and humans. Quantitative studies of inter-areal connectivity have revealed unexpectedly many pathways and a wide range of connection strengths in mouse and macaque cortex. In humans, advances in analyzing ‘structural’ and ‘functional’ connectivity using powerful but indirect noninvasive neuroimaging methods are yielding intriguing insights about brain circuits, their variability across individuals, and their relationship to behavior. PMID:24183027

  7. 25th anniversary article: a decade of organic/polymeric photovoltaic research.

    PubMed

    Dou, Letian; You, Jingbi; Hong, Ziruo; Xu, Zheng; Li, Gang; Street, Robert A; Yang, Yang

    2013-12-10

    Organic photovoltaic (OPV) technology has been developed and improved from a fancy concept with less than 1% power conversion efficiency (PCE) to over 10% PCE, particularly through the efforts in the last decade. The significant progress is the result of multidisciplinary research ranging from chemistry, material science, physics, and engineering. These efforts include the design and synthesis of novel compounds, understanding and controlling the film morphology, elucidating the device mechanisms, developing new device architectures, and improving large-scale manufacture. All of these achievements catalyzed the rapid growth of the OPV technology. This review article takes a retrospective look at the research and development of OPV, and focuses on recent advances of solution-processed materials and devices during the last decade, particular the polymer version of the materials and devices. The work in this field is exciting and OPV technology is a promising candidate for future thin film solar cells.

  8. 25th anniversary article: semiconductor nanowires--synthesis, characterization, and applications.

    PubMed

    Dasgupta, Neil P; Sun, Jianwei; Liu, Chong; Brittman, Sarah; Andrews, Sean C; Lim, Jongwoo; Gao, Hanwei; Yan, Ruoxue; Yang, Peidong

    2014-04-09

    Semiconductor nanowires (NWs) have been studied extensively for over two decades for their novel electronic, photonic, thermal, electrochemical and mechanical properties. This comprehensive review article summarizes major advances in the synthesis, characterization, and application of these materials in the past decade. Developments in the understanding of the fundamental principles of "bottom-up" growth mechanisms are presented, with an emphasis on rational control of the morphology, stoichiometry, and crystal structure of the materials. This is followed by a discussion of the application of nanowires in i) electronic, ii) sensor, iii) photonic, iv) thermoelectric, v) photovoltaic, vi) photoelectrochemical, vii) battery, viii) mechanical, and ix) biological applications. Throughout the discussion, a detailed explanation of the unique properties associated with the one-dimensional nanowire geometry will be presented, and the benefits of these properties for the various applications will be highlighted. The review concludes with a brief perspective on future research directions, and remaining barriers which must be overcome for the successful commercial application of these technologies. Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. 25th anniversary article: Bulk heterojunction solar cells: understanding the mechanism of operation.

    PubMed

    Heeger, Alan J

    2014-01-08

    The status of understanding of the operation of bulk heterojunction (BHJ) solar cells is reviewed. Because the carrier photoexcitation recombination lengths are typically 10 nm in these disordered materials, the length scale for self-assembly must be of order 10-20 nm. Experiments have verified the existence of the BHJ nanostructure, but the morphology remains complex and a limiting factor. Three steps are required for generation of electrical power: i) absorption of photons from the sun; ii) photoinduced charge separation and the generation of mobile carriers; iii) collection of electrons and holes at opposite electrodes. The ultrafast charge transfer process arises from fundamental quantum uncertainty; mobile carriers are directly generated (electrons in the acceptor domains and holes in the donor domains) by the ultrafast charge transfer (≈70%) with ≈30% generated by exciton diffusion to a charge separating heterojunction. Sweep-out of the mobile carriers by the internal field prior to recombination is essential for high performance. Bimolecular recombination dominates in materials where the donor and acceptor phases are pure. Impurities degrade performance by introducing Shockly-Read-Hall decay. The review concludes with a summary of the problems to be solved to achieve the predicted power conversion efficiencies of >20% for a single cell.

  10. 25th anniversary article: Colloidal quantum dot materials and devices: a quarter-century of advances.

    PubMed

    Kim, Jin Young; Voznyy, Oleksandr; Zhitomirsky, David; Sargent, Edward H

    2013-09-25

    Colloidal quantum dot (CQD) optoelectronics offers a compelling combination of low-cost, large-area solution processing, and spectral tunability through the quantum size effect. Since early reports of size-tunable light emission from solution-synthesized CQDs over 25 years ago, tremendous progress has been made in synthesis and assembly, optical and electrical properties, materials processing, and optoelectronic applications of these materials. Here some of the major developments in this field are reviewed, touching on key milestones as well as future opportunities.

  11. 1984-2008. Predictions for Higher Education. From the 25th Anniversary Colloquium. [Proceedings].

    ERIC Educational Resources Information Center

    Hardee, Melvene Draheim, Ed.

    Predictions on higher education for 1984-2009 are presented in the proceedings of a colloquium of the Institute for Studies in Higher Education of Florida State University. Presentations were made at the colloquium by 10 graduates of the university whose current positions represent administration-management, instruction, research, and student…

  12. A resolution recognizing the 25th anniversary of the Chernobyl nuclear disaster.

    THOMAS, 112th Congress

    Sen. Lugar, Richard G. [R-IN

    2011-04-14

    05/09/2011 Resolution agreed to in Senate with an amendment and with a preamble by Unanimous Consent. (text: CR S2799) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  13. 25th anniversary article: label-free electrical biodetection using carbon nanostructures.

    PubMed

    Balasubramanian, Kannan; Kern, Klaus

    2014-02-26

    Nanostructures are promising candidates for use as active materials for the detection of chemical and biological species, mainly due to the high surface-to-volume ratio and the unique physical properties arising at the nanoscale. Among the various nanostructures, materials comprised of sp(2) -carbon enjoy a unique position due to the possibility to readily prepare them in various dimensions ranging from 0D, through 1D to 2D. This review focuses on the use of 1D (carbon nanotubes) and 2D (graphene) carbon nanostructures for the detection of biologically relevant molecules. A key advantage is the possibility to perform the sensing operation without the use of any labels or complex reaction schemes. Along this spirit, various strategies reported for the label-free electrical detection of biomolecules using carbon nanostructures are discussed. With their promise for ultimate sensitivity and the capability to attain high selectivity through controlled chemical functionalization, carbon-based nanobiosensors are expected to open avenues to novel diagnostic tools as well as to obtain new fundamental insight into biomolecular interactions down to the single molecule level.

  14. 25th Anniversary Article: Ordered Polymer Structures for the Engineering of Photons and Phonons

    PubMed Central

    Lee, Jae-Hwang; Koh, Cheong Yang; Singer, Jonathan P; Jeon, Seog-Jin; Maldovan, Martin; Stein, Ori; Thomas, Edwin L

    2014-01-01

    The engineering of optical and acoustic material functionalities via construction of ordered local and global architectures on various length scales commensurate with and well below the characteristic length scales of photons and phonons in the material is an indispensable and powerful means to develop novel materials. In the current mature status of photonics, polymers hold a pivotal role in various application areas such as light-emission, sensing, energy, and displays, with exclusive advantages despite their relatively low dielectric constants. Moreover, in the nascent field of phononics, polymers are expected to be a superior material platform due to the ability for readily fabricated complex polymer structures possessing a wide range of mechanical behaviors, complete phononic bandgaps, and resonant architectures. In this review, polymer-centric photonic and phononic crystals and metamaterials are highlighted, and basic concepts, fabrication techniques, selected functional polymers, applications, and emerging ideas are introduced. PMID:24338738

  15. 25th anniversary article: polymer-particle composites: phase stability and applications in electrochemical energy storage.

    PubMed

    Srivastava, Samanvaya; Schaefer, Jennifer L; Yang, Zichao; Tu, Zhengyuan; Archer, Lynden A

    2014-01-15

    Polymer-particle composites are used in virtually every field of technology. When the particles approach nanometer dimensions, large interfacial regions are created. In favorable situations, the spatial distribution of these interfaces can be controlled to create new hybrid materials with physical and transport properties inaccessible in their constituents or poorly prepared mixtures. This review surveys progress in the last decade in understanding phase behavior, structure, and properties of nanoparticle-polymer composites. The review takes a decidedly polymers perspective and explores how physical and chemical approaches may be employed to create hybrids with controlled distribution of particles. Applications are studied in two contexts of contemporary interest: battery electrolytes and electrodes. In the former, the role of dispersed and aggregated particles on ion-transport is considered. In the latter, the polymer is employed in such small quantities that it has been historically given titles such as binder and carbon precursor that underscore its perceived secondary role. Considering the myriad functions the binder plays in an electrode, it is surprising that highly filled composites have not received more attention. Opportunities in this and related areas are highlighted where recent advances in synthesis and polymer science are inspiring new approaches, and where newcomers to the field could make important contributions.

  16. Development and External Debt: Friend or Foe? Academy for Educational Development 25th Anniversary Seminar Series.

    ERIC Educational Resources Information Center

    Hope, Nicholas C.

    Arguing that the benefits from borrowing abroad exceed the costs recently imposed on countries through debt-servicing difficulties, this paper defines debt as an engine of growth, forcing the borrower to produce goods efficiently, export them, and function competitively in the international market. Debt-servicing difficulties of developing nations…

  17. A resolution honoring the Blackstone Valley Tourism Council on the celebration of its 25th anniversary.

    THOMAS, 111th Congress

    Sen. Whitehouse, Sheldon [D-RI

    2010-03-24

    04/14/2010 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (text: CR S2326) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  18. 25th Anniversary Article: A Soft Future: From Robots and Sensor Skin to Energy Harvesters

    PubMed Central

    Bauer, Siegfried; Bauer-Gogonea, Simona; Graz, Ingrid; Kaltenbrunner, Martin; Keplinger, Christoph; Schwödiauer, Reinhard

    2014-01-01

    Scientists are exploring elastic and soft forms of robots, electronic skin and energy harvesters, dreaming to mimic nature and to enable novel applications in wide fields, from consumer and mobile appliances to biomedical systems, sports and healthcare. All conceivable classes of materials with a wide range of mechanical, physical and chemical properties are employed, from liquids and gels to organic and inorganic solids. Functionalities never seen before are achieved. In this review we discuss soft robots which allow actuation with several degrees of freedom. We show that different actuation mechanisms lead to similar actuators, capable of complex and smooth movements in 3d space. We introduce latest research examples in sensor skin development and discuss ultraflexible electronic circuits, light emitting diodes and solar cells as examples. Additional functionalities of sensor skin, such as visual sensors inspired by animal eyes, camouflage, self-cleaning and healing and on-skin energy storage and generation are briefly reviewed. Finally, we discuss a paradigm change in energy harvesting, away from hard energy generators to soft ones based on dielectric elastomers. Such systems are shown to work with high energy of conversion, making them potentially interesting for harvesting mechanical energy from human gait, winds and ocean waves. PMID:24307641

  19. A resolution recognizing the 25th anniversary of the Chernobyl nuclear disaster.

    THOMAS, 112th Congress

    Sen. Lugar, Richard G. [R-IN

    2011-04-14

    Senate - 05/09/2011 Resolution agreed to in Senate with an amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  20. Development and External Debt: Friend or Foe? Academy for Educational Development 25th Anniversary Seminar Series.

    ERIC Educational Resources Information Center

    Hope, Nicholas C.

    Arguing that the benefits from borrowing abroad exceed the costs recently imposed on countries through debt-servicing difficulties, this paper defines debt as an engine of growth, forcing the borrower to produce goods efficiently, export them, and function competitively in the international market. Debt-servicing difficulties of developing nations…

  1. 25th anniversary article: organic electronics marries photochromism: generation of multifunctional interfaces, materials, and devices.

    PubMed

    Orgiu, Emanuele; Samorì, Paolo

    2014-03-26

    Organic semiconductors have garnered significant interest as key components for flexible, low-cost, and large-area electronics. Hitherto, both materials and processing thereof seems to head towards a mature technology which shall ultimately meet expectations and efforts built up over the past years. However, by its own organic electronics cannot compete or complement the silicon-based electronics in integrating multiple functions in a small area unless novel solutions are brought into play. Photochromic molecules are small organic molecules able to undergo reversible photochemical isomerization between (at least) two (meta)stable states which exhibit markedly different properties. They can be embedded as additional component in organic-based materials ready to be exploited in devices such as OLEDs, OFETs, and OLETs. The structurally controlled incorporation of photochromic molecules can be done at various interfaces of a device, including the electrode/semiconductor or dielectric/semiconductor interface, or even as a binary mixture in the active layer, in order to impart a light responsive nature to the device. This can be accomplished by modulating via a light stimulus fundamental physico-chemical properties such as charge injection and transport in the device.

  2. 25th anniversary article: carbon nanotube- and graphene-based transparent conductive films for optoelectronic devices.

    PubMed

    Du, Jinhong; Pei, Songfeng; Ma, Laipeng; Cheng, Hui-Ming

    2014-04-02

    Carbon nanotube (CNT)- and graphene (G)-based transparent conductive films (TCFs) are two promising alternatives for commonly-used indium tin oxide-based TCFs for future flexible optoelectronic devices. This review comprehensively summarizes recent progress in the fabrication, properties, modification, patterning, and integration of CNT- and G-TCFs into optoelectronic devices. Their potential applications and challenges in optoelectronic devices, such as organic photovoltaic cells, organic light emitting diodes and touch panels, are discussed in detail. More importantly, their key characteristics and advantages for use in these devices are compared. Despite many challenges, CNT- and G-TCFs have demonstrated great potential in various optoelectronic devices and have already been used for some products like touch panels of smartphones. This illustrates the significant opportunities for the industrial use of CNTs and graphene, and hence pushes nanoscience and nanotechnology one step towards practical applications.

  3. 25th Anniversary Article: Organic Field-Effect Transistors: The Path Beyond Amorphous Silicon

    PubMed Central

    Sirringhaus, Henning

    2014-01-01

    Over the past 25 years, organic field-effect transistors (OFETs) have witnessed impressive improvements in materials performance by 3–4 orders of magnitude, and many of the key materials discoveries have been published in Advanced Materials. This includes some of the most recent demonstrations of organic field-effect transistors with performance that clearly exceeds that of benchmark amorphous silicon-based devices. In this article, state-of-the-art in OFETs are reviewed in light of requirements for demanding future applications, in particular active-matrix addressing for flexible organic light-emitting diode (OLED) displays. An overview is provided over both small molecule and conjugated polymer materials for which field-effect mobilities exceeding > 1 cm2 V–1 s–1 have been reported. Current understanding is also reviewed of their charge transport physics that allows reaching such unexpectedly high mobilities in these weakly van der Waals bonded and structurally comparatively disordered materials with a view towards understanding the potential for further improvement in performance in the future. PMID:24443057

  4. A resolution honoring the Blackstone Valley Tourism Council on the celebration of its 25th anniversary.

    THOMAS, 111th Congress

    Sen. Whitehouse, Sheldon [D-RI

    2010-03-24

    04/14/2010 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  5. 25th anniversary article: materials for high-performance biodegradable semiconductor devices.

    PubMed

    Hwang, Suk-Won; Park, Gayoung; Cheng, Huanyu; Song, Jun-Kyul; Kang, Seung-Kyun; Yin, Lan; Kim, Jae-Hwan; Omenetto, Fiorenzo G; Huang, Yonggang; Lee, Kyung-Mi; Rogers, John A

    2014-04-02

    We review recent progress in a class of silicon-based electronics that is capable of complete, controlled dissolution when immersed in water or bio-fluids. This type of technology, referred to in a broader sense as transient electronics, has potential applications in resorbable biomedical devices, eco-friendly electronics, environmental sensors, secure hardware systems and others. New results reported here include studies of the kinetics of hydrolysis of nanomembranes of single crystalline silicon in bio-fluids and aqueous solutions at various pH levels and temperatures. Evaluations of toxicity using live animal models and test coupons of transient electronic materials provide some evidence of their biocompatibility, thereby suggesting potential for use in bioresorbable electronic implants.

  6. Newspapers on Microfilm. Catalog and Price List 1971, 25th Anniversary Edition.

    ERIC Educational Resources Information Center

    1971

    Over 5500 current and backfile titles of American, foreign, and Black community newspapers that may be purchased on 35mm. roll microfilm are indexed in this catalog. Historical annotations are provided for selected American, Asian, and other foreign newspapers as well as for collections which focus on areas of special interest: early America, the…

  7. A resolution recognizing the 25th anniversary of the Chernobyl nuclear disaster.

    THOMAS, 112th Congress

    Sen. Lugar, Richard G. [R-IN

    2011-04-14

    05/09/2011 Resolution agreed to in Senate with an amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  8. 25th anniversary article: A soft future: from robots and sensor skin to energy harvesters.

    PubMed

    Bauer, Siegfried; Bauer-Gogonea, Simona; Graz, Ingrid; Kaltenbrunner, Martin; Keplinger, Christoph; Schwödiauer, Reinhard

    2014-01-08

    Scientists are exploring elastic and soft forms of robots, electronic skin and energy harvesters, dreaming to mimic nature and to enable novel applications in wide fields, from consumer and mobile appliances to biomedical systems, sports and healthcare. All conceivable classes of materials with a wide range of mechanical, physical and chemical properties are employed, from liquids and gels to organic and inorganic solids. Functionalities never seen before are achieved. In this review we discuss soft robots which allow actuation with several degrees of freedom. We show that different actuation mechanisms lead to similar actuators, capable of complex and smooth movements in 3d space. We introduce latest research examples in sensor skin development and discuss ultraflexible electronic circuits, light emitting diodes and solar cells as examples. Additional functionalities of sensor skin, such as visual sensors inspired by animal eyes, camouflage, self-cleaning and healing and on-skin energy storage and generation are briefly reviewed. Finally, we discuss a paradigm change in energy harvesting, away from hard energy generators to soft ones based on dielectric elastomers. Such systems are shown to work with high energy of conversion, making them potentially interesting for harvesting mechanical energy from human gait, winds and ocean waves.

  9. 25th anniversary article: CVD polymers: a new paradigm for surface modification and device fabrication.

    PubMed

    Coclite, Anna Maria; Howden, Rachel M; Borrelli, David C; Petruczok, Christy D; Yang, Rong; Yagüe, Jose Luis; Ugur, Asli; Chen, Nan; Lee, Sunghwan; Jo, Won Jun; Liu, Andong; Wang, Xiaoxue; Gleason, Karen K

    2013-10-11

    Well-adhered, conformal, thin (<100 nm) coatings can easily be obtained by chemical vapor deposition (CVD) for a variety of technological applications. Room temperature modification with functional polymers can be achieved on virtually any substrate: organic, inorganic, rigid, flexible, planar, three-dimensional, dense, or porous. In CVD polymerization, the monomer(s) are delivered to the surface through the vapor phase and then undergo simultaneous polymerization and thin film formation. By eliminating the need to dissolve macromolecules, CVD enables insoluble polymers to be coated and prevents solvent damage to the substrate. CVD film growth proceeds from the substrate up, allowing for interfacial engineering, real-time monitoring, and thickness control. Initiated-CVD shows successful results in terms of rationally designed micro- and nanoengineered materials to control molecular interactions at material surfaces. The success of oxidative-CVD is mainly demonstrated for the deposition of organic conducting and semiconducting polymers.

  10. Just Schools. A Special Report Commemorating the 25th Anniversary of the Brown Decision.

    ERIC Educational Resources Information Center

    Southern Exposure, 1979

    1979-01-01

    The focus of this volume is on changes in the status of Southern blacks since the Brown decision, and problems still to be solved, especially in the area of equal educational opportunity. Several articles describe specific events which occurred during the civil rights movement and discuss their impact on school integration. Other authors discuss…

  11. 25th anniversary article: progress in chemistry and applications of functional indigos for organic electronics.

    PubMed

    Głowacki, Eric Daniel; Voss, Gundula; Sariciftci, Niyazi Serdar

    2013-12-17

    Indigo and its derivatives are dyes and pigments with a long and distinguished history in organic chemistry. Recently, applications of this 'old' structure as a functional organic building block for organic electronics applications have renewed interest in these molecules and their remarkable chemical and physical properties. Natural-origin indigos have been processed in fully bio-compatible field effect transistors, operating with ambipolar mobilities up to 0.5 cm(2) /Vs and air-stability. The synthetic derivative isoindigo has emerged as one of the most successful building-blocks for semiconducting polymers for plastic solar cells with efficiencies > 5%. Another isomer of indigo, epindolidione, has also been shown to be one of the best reported organic transistor materials in terms of mobility (∼2 cm(2) /Vs) and stability. This progress report aims to review very recent applications of indigoids in organic electronics, but especially to logically bridge together the hereto independent research directions on indigo, isoindigo, and other materials inspired by historical dye chemistry: a field which was the root of the development of modern chemistry in the first place.

  12. 25th anniversary article: hybrid nanostructures based on two-dimensional nanomaterials.

    PubMed

    Huang, Xiao; Tan, Chaoliang; Yin, Zongyou; Zhang, Hua

    2014-04-09

    Two-dimensional (2D) nanomaterials, such as graphene and transition metal dichalcogenides (TMDs), receive a lot of attention, because of their intriguing properties and wide applications in catalysis, energy-storage devices, electronics, optoelectronics, and so on. To further enhance the performance of their application, these 2D nanomaterials are hybridized with other functional nanostructures. In this review, the latest studies of 2D nanomaterial-based hybrid nanostructures are discussed, focusing on their preparation methods, properties, and applications.

  13. Graduate Education--Past--Present--Future. Proceedings of the Annual Meeting of the Council of Graduate Schools in the United States (25th, Anaheim, California, December 11-14, 1985).

    ERIC Educational Resources Information Center

    Khalil, Edna M., Ed.

    This proceedings document contains papers presented at the 25th anniversary meeting of the Council of Graduate Schools in the United States (CGS); information on the CGS business meeting, notices of awards presentations, copies of the CGS constitution and bylaws, and a CGS membership list. Topics and presenters are as follows: "Current Issues…

  14. PREFACE 25th Summer School and International Symposium on the Physics of Ionized Gases - SPIG 2010

    NASA Astrophysics Data System (ADS)

    Popović, Luka Č.; Kuraica, Milorad M.

    2010-11-01

    This volume of the Journal of Physics: Conference Series contains the Invited lectures, Topical invited lectures and Progress reports presented at the 25th Summer School and International Symposium on the Physics of Ionized Gases - SPIG 2010. The conference was held in Donji Milanovac, Serbia, from 29 August to 3 September 2010. Since SPIG has a long tradition and this is a jubilee anniversary, the 25th one, we had the opportunity to recall the history of the Conference (see the first paper in this proceedings). The structure of papers in this Proceedings covers the following sections: Atomic Collision Processes, Particle and Laser Beam Interactions with Solids, Low Temperature Plasmas and General Plasmas. As the four above mentioned topics often overlap and merge in numerous fundamental studies and more importantly applications, SPIG in general serves as a venue for exchanging ideas in the related fields. We hope that this Proceedings will be an important source of information about progress in plasma physics and will be useful, first of all, for students, and also for plasma physics scientists. The Editors would like to thank the invited speakers for their participation at SPIG 2010 and for their efforts writing contributions for this Proceedings. We also express our gratitude to the members of Scientific and Organizing committees for their efforts in organizing this SPIG. Especially we would like to thank the Ministry of Science and Technological Development of Republic of Serbia for financial support as well as the European Physical Society (EPS) for supporting the participation of three younger scientists. Luka Č Popović Milorad Kuraica October 2010

  15. Literacy: Celebration and Challenge. Illinois Reading Council Silver Anniversary Monograph.

    ERIC Educational Resources Information Center

    Johns, Jerry L., Ed.; And Others

    Celebrating the Illinois Reading Council's 25th anniversary year, this 2-part monograph presents 11 papers on diverse aspects of reading and literacy. Papers in the first part, called "Historical Reflections and Challenges," are: "The Illinois Reading Council Celebrates 25 Years" (John W. Logan); "The 'Illinois Reading…

  16. Acupuncture and facial rejuvenation.

    PubMed

    Barrett, John B

    2005-01-01

    In traditional Oriental medicine, facial rejuvenation is achieved by inserting acupuncture needles at different points along designated channels to attain tonification or sedation effects. According to the author, treatment benefits include elimination of some wrinkles and decrease in length and depth of others, decrease of facial edema, decrease of acne, improvement of facial muscle tone, improved skin texture with tighter pores, and decrease of sagging around the eyes, cheeks, chin, and neck.

  17. Rejuvenation of aging hearts.

    PubMed

    Mendelsohn, Andrew R; Larrick, James W

    2013-08-01

    Specific subtle changes in regulation or activity of factors that maintain homeostasis and cell differentiation may play significant roles in mammalian aging. Drift resulting from reaching the end of an organism's developmental program might involve a specific ordered set of changes. Several studies have suggested that dysfunctional changes associated with aging in skeletal muscle, neurons, and hematopoietic stem cells may be caused by specific changes either in the extracellular environment or in intracellular regulatory networks and that such dysfunction may be reversible. On the basis these data, Loffredo et al. hypothesized that extrinsic circulating factors in young mice might reverse cardiac aging. Parabiosis, the surgical linking of circulations between old and young mice, was employed to identify an anti-hypertrophic factor (growth differentiation factor 11 [GDF-11]) that appears to rejuvenate aging murine hearts, raising exciting prospects for the development of anti-aging therapeutics. However, much work remains to be done to evaluate the utility of GDF-11 as a therapeutic rejuvenation factor. Similar rejuvenating factors for diverse tissues may exist as well and will hopefully be identified in the near future.

  18. Proceedings of the 25th intersociety energy conversion engineering conference

    SciTech Connect

    Nelson, P.A.; Schertz, W.W.; Till, R.H.

    1990-01-01

    This book contains the proceedings of the 25th Intersociety Energy Conversion Engineering Conference. Volume 5 is organized under the following headings: Photovoltaics I, Photovoltaics II, Geothermal power, Thermochemical conversion of biomass, Energy from waste and biomass, Solar thermal systems for environmental applications, Solar thermal low temperature systems and components, Solar thermal high temperature systems and components, Wind systems, Space power sterling technology Stirling cooler developments, Stirling solar terrestrial I, Stirling solar terrestrial II, Stirling engine generator sets, Stirling models and simulations, Stirling engine analysis, Stirling models and simulations, Stirling engine analysis, Stirling engine loss understanding, Novel engine concepts, Coal conversion and utilization, Power cycles, MHD water propulsion I, Underwater vehicle powerplants - performance, MHD underwater propulsion II, Nuclear power, Update of advanced nuclear power reactor concepts.

  19. Rejuvenating the senescent heart

    PubMed Central

    Nguyen, Nathalie; Sussman, Mark A.

    2015-01-01

    Purpose of review The purpose of this review is to provide an update on the cardiac stem cell field with an emphasis on aging and to suggest some relevant strategies directed toward rejuvenation of the senescent heart. Recent findings Stem cells were long considered as a fountain of youth and were assumed to be equipped against any form of aging effect. However, it is now clear that stem cells suffer the consequences of aging as well. With the discovery that cardiac stem cells reside in the heart comes the question whether these cells are also impaired upon aging. As cardiac stem cell properties are also altered with age, autologous stem cell-based therapy to treat heart failure will benefit from new improved strategies. Summary With the goal to improve stem cell properties that are impaired upon aging, some strategies are highlighted. Genetic modification of adult human cardiac progenitor cells prior to autologous stem cell-based therapy, delivery of the next generation of stem cells such as CardioChimeras and CardioClusters, and improvement of the myocardial environment with rejuvenating factors constitute some of the possibilities and are discussed in more detail in this review. PMID:25760821

  20. Witnessing Solar Rejuvenation

    NASA Astrophysics Data System (ADS)

    Kohler, Susanna

    2015-09-01

    At the end of last year, the Suns large-scale magnetic field suddenly strengthened, reaching its highest value in over two decades. Here, Neil Sheeley and Yi-Ming Wang (both of the Naval Research Laboratory) propose an explanation for why this happened and what it predicts for the next solar cycle.Magnetic StrengtheningUntil midway through 2014, solar cycle 24 the current solar cycle was remarkably quiet. Even at its peak, it averaged only 79 sunspots per year, compared to maximums of up to 190 in recent cycles. Thus it was rather surprising when, toward the end of 2014, the Suns large-scale magnetic field underwent a sudden rejuvenation, with its mean field leaping up to its highest values since 1991 and causing unprecedentedly large numbers of coronal loops to collapse inward.Yet in spite of the increase we observed in the Suns open flux (the magnetic flux leaving the Suns atmosphere, measured from Earth), there was not a significant increase in solar activity, as indicated by sunspot number and the rate of coronal mass ejections. This means that the number of sources of magnetic flux didnt increase so Sheeley and Wang conclude that flux must instead have been emerging from those sources in a more efficient way! But how?Aligned ActivityWSO open flux and the radial component of the interplanetary magnetic field (measures of the magnetic flux leaving the Suns photosphere and heliosphere, respectively), compared to sunspot number (in units of 100 sunspots). A sudden increase in flux is visible after the peak of each of the last four sunspot cycles. Click for a larger view! [Sheeley Wang 2015]The authors show that the active regions on the solar surface in late 2014 lined up in such a way that the emerging flux was enhanced, forming a strong equatorial dipole field that accounts for the sudden rejuvenation observed.Interestingly, this rejuvenation of the Suns open flux wasnt just a one-time thing; similar bursts have occurred shortly after the peak of every sunspot

  1. Andropause: invention, prevention, rejuvenation.

    PubMed

    Handelsman, David J; Liu, Peter Y

    2005-03-01

    There is a growing interest, as well as a booming industry, in the use of testosterone therapy for middle-aged and older men. This interest has led to the definition of a new condition, termed 'andropause', meaning the putative somatic consequences of gradually falling blood testosterone concentrations during male aging. This trend risks replicating both the rejuvenation fads of a century ago and the recent experience in estrogen therapy for menopause that has been propelled for decades by advocacy substituting for reliable scientific evidence. The current status and prospects for androgen therapy in middle-aged and older men should be evaluated critically from the perspective of male reproductive health during aging. This review appraises current knowledge with a focus on the questionable basis for using androgen therapy to improve male reproductive health during aging.

  2. Thermal rejuvenation in metallic glasses

    PubMed Central

    Saida, Junji; Yamada, Rui; Wakeda, Masato; Ogata, Shigenobu

    2017-01-01

    Abstract Structural rejuvenation in metallic glasses by a thermal process (i.e. through recovery annealing) was investigated experimentally and theoretically for various alloy compositions. An increase in the potential energy, a decrease in the density, and a change in the local structure as well as mechanical softening were observed after thermal rejuvenation. Two parameters, one related to the annealing temperature, T a/T g, and the other related to the cooling rate during the recovery annealing process, V c/V i, were proposed to evaluate the rejuvenation phenomena. A rejuvenation map was constructed using these two parameters. Since the thermal history of metallic glasses is reset above 1.2T g, accompanied by a change in the local structure, it is essential that the condition of T a/T g ≥ 1.2 is satisfied during annealing. The glassy structure transforms into a more disordered state with the decomposition of icosahedral short-range order within this temperature range. Therefore, a new glassy structure (rejuvenation) depending on the subsequent quenching rate is generated. Partial rejuvenation also occurs in a Zr55Al10Ni5Cu30 bulk metallic glass when annealing is performed at a low temperature (T a/T g ~ 1.07) followed by rapid cooling. This behavior probably originates from disordering in the weakly bonded (loosely packed) region. This study provides a novel approach to improving the mechanical properties of metallic glasses by controlling their glassy structure. PMID:28458739

  3. Complications in periocular rejuvenation.

    PubMed

    Mack, William P

    2010-08-01

    Thorough preoperative evaluation with meticulous surgical planning to achieve facial aesthetic balance between the forehead, eyelids, and midface is imperative to avoid or decrease potential functional and/or cosmetic complications in cosmetic periocular surgery. Before performing surgery, the physician should be aware of the patient's history of dry eyes, previous facial trauma, previous injection of Botox Cosmetic, history of previous laser-assisted in situ keratomileusis, and past facial surgery. A full evaluation should be performed on the upper eyelid/brow region to assess for the presence of brow ptosis, brow/eyelid asymmetry, dermatochalasis/pseudodermatochalasis, eyelid ptosis, and deep superior sulcus. On the lower eyelid/cheek examination, special attention should be directed to the diagnosis of underlying negative vector, dry eyes, prominent eyes, lower lid retraction, ectropion, lateral canthal dystopia, lower eyelid laxity, scleral show, and lagophthalmos, with a rejuvenation goal that focuses on obtaining a youthful fullness through repositioning and reinforcing efforts to avoid the negative effects of hollowness. Intraoperative and postoperative medical and surgical management of cosmetic periocular surgery complications focus on decreasing the risk of postoperative ptosis, lagophthalmos, lid retraction, and lid asymmetry, with special attention to limiting the risk of visual loss secondary to orbital hemorrhage. Copyright 2010 Elsevier Inc. All rights reserved.

  4. 25th PolyMAC Conference, June 13-15, 1995

    SciTech Connect

    Smith, P.F.

    1995-06-01

    This document contains abstracts of reports presented at the 25th Annual Polymeric, Materials, Adhesives and Composites Symposium. Reports covered aging, testing and performance, and encapsulating materials.

  5. Kilauea's Ongoing Eruption: 25th Year Brings Major Changes

    NASA Astrophysics Data System (ADS)

    Orr, T. R.

    2007-12-01

    2007 marks the 25th year of nearly continuous eruption on Kilauea's east rift zone. Episodic high lava fountains, which built the Pu`u `O`o cone during the first three years of the eruption, ended in 1986. Activity then migrated downrift and the Kupaianaha shield was formed by passive effusion of lava. The change in eruptive style resulted in a switch at Pu`u `O`o from cone construction to cone collapse that has been ongoing for the last two decades. Activity at Kupaianaha ceased in 1992, and the eruption resumed at Pu`u `O`o. The eruptive style established at Kupaianaha continued, however, with continuous effusion from vents on the southwest flank of the Pu`u `O`o cone. The last 15 years have been characterized by the formation of relatively stable tube systems---broken only by a brief fissure eruption uprift of Pu`u `O`o in 1997---that have carried lava from the flank vents to the ocean about 9 km away. The Prince Kuhio Kalanianaole (PKK) tube, the most recent of these tube systems to develop, was active from March 2004 to June 2007. The PKK flow was emplaced almost entirely on older flows of this eruption and entered the ocean in several locations over a span of 6 km. The "Father's Day" intrusion of June 17--19, 2007, robbed the supply of magma to Pu`u `O`o and, thus, the active flow field. The floor of the Pu`u `O`o crater dropped 80--100 m, the PKK tube system drained, and the active flows and ocean entry quickly stagnated. On June 19, a short-lived fissure eruption broke out low on the east flank of Kane Nui o Hamo, about 6 km uprift of Pu`u `O`o, burying only 0.22 hectares. The eruption at Kilauea paused from June 20 through July 1 or 2, when lava returned to Pu`u `O`o and began refilling the collapsed crater. Near midnight on July 20--21, after at least 19 days of lava lake growth, the lava pond within the Pu`u `O`o crater drained suddenly when a series of fissures opened on the east flank of the cone and propagated ~2 km downrift. The new activity, dubbed

  6. Proceedings of the 25th Himalaya-Karakoram-Tibet Workshop

    USGS Publications Warehouse

    Leech, Mary L.; Klemperer, Simon L.; Mooney, Walter D.

    2010-01-01

    For a quarter of a century the Himalayan-Karakoram-Tibet (HKT) Workshop has provided scientists studying the India-Asia collision system a wonderful opportunity for workshop-style discussion with colleagues working in this region. In 2010, HKT returns to North America for the first time since 1996. The 25th international workshop is held from June 7 to10 at San Francisco State University, California. The international community was invited to contribute scientific papers to the workshop, on all aspects of geoscience research in the geographic area of the Tibetan Plateau and its bounding ranges and basins, from basic mapping to geochemical and isotopic analyses to large-scale geophysical imaging experiments. In recognition of the involvement of U.S. Geological Survey (USGS) scientists in a wide range of these activities, the USGS agreed to publish the extended abstracts of the numerous components of HKT-25 as an online Open-File Report, thereby ensuring the wide availability and distribution of these abstracts, particularly in the HKT countries from which many active workers are precluded by cost from attending international meetings. In addition to the workshop characterized by contributed presentations, participants were invited to attend a pre-meeting field trip from the Coast Ranges to the Sierra Nevada, to allow the international group to consider how the tectonic elements of the Pacific margin compare to those of the Himalayan belt. Following the workshop, the National Science Foundation (NSF) sponsored a workshop on the 'Future directions for NSF-sponsored geoscience research in the Himalaya/Tibet' intended to provide NSF Program Directors with a clear statement and vision of community goals for the future, including the scientific progress we can expect if NSF continues its support of projects in this geographic region, and to identify which key geoscience problems and processes are best addressed in the Himalaya and Tibet, what key datasets are needed, and

  7. A resolution celebrating February 2, 2011, as the 25th anniversary of "National Women and Girls in Sports Day".

    THOMAS, 112th Congress

    Sen. Snowe, Olympia J. [R-ME

    2011-01-27

    02/02/2011 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (text: CR S492) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  8. A resolution congratulating the National Institute of Nursing Research on the occasion of its 25th anniversary.

    THOMAS, 111th Congress

    Sen. Inouye, Daniel K. [D-HI

    2010-09-23

    Senate - 09/23/2010 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  9. 25th Anniversary of Pollution Prevention Act Serves as Reminder That Everyone Can Take Steps for a Healthy Environment

    EPA Pesticide Factsheets

    PHILADELPHIA (Sept. 21, 2015) Each year, the U.S. Environmental Protection Agency celebrates Pollution Prevention Week - the third week in September - to highlight ways the agency is working with an array of organizations to prevent pollution right

  10. 25th anniversary article: exploring nanoscaled matter from speciation to phase diagrams: metal phosphide nanoparticles as a case of study.

    PubMed

    Carenco, Sophie; Portehault, David; Boissière, Cédric; Mézailles, Nicolas; Sanchez, Clément

    2014-01-22

    The notions of nanoscale "phase speciation" and "phase diagram" are defined and discussed in terms of kinetic and thermodynamic controls, based on the case of metal phosphide nanoparticles. After an overview of the most successful synthetic routes for these exotic nanomaterials, the cases of InP, Ni2 P, Ni12 P5 and Pdx Py are discussed in detail to highlight the relationship between composition, structure, and size at the nanoscale. The influence of morphology is discussed next by comparing the behavior of Cu3 P nanophases with those of Nix Py , FeP/Fe2 P, and CoP/Co2 P. Perspectives provide the reader with methodological guidelines for further investigation of nanoscale "phase diagrams", and their use for optimized synthesis of new functional nanomaterials.

  11. 25th anniversary article: Design of polymethine dyes for all-optical switching applications: guidance from theoretical and computational studies.

    PubMed

    Gieseking, Rebecca L; Mukhopadhyay, Sukrit; Risko, Chad; Marder, Seth R; Brédas, Jean-Luc

    2014-01-08

    All-optical switching--controlling light with light--has the potential to meet the ever-increasing demand for data transmission bandwidth. The development of organic π-conjugated molecular materials with the requisite properties for all-optical switching applications has long proven to be a significant challenge. However, recent advances demonstrate that polymethine dyes have the potential to meet the necessary requirements. In this review, we explore the theoretical underpinnings that guide the design of π-conjugated materials for all-optical switching applications. We underline, from a computational chemistry standpoint, the relationships among chemical structure, electronic structure, and optical properties that make polymethines such promising materials.

  12. Biotechnology and the Third World: Panacea or Recipe for Social Disaster? Academy for Educational Development 25th Anniversary Series.

    ERIC Educational Resources Information Center

    Morehouse, Ward

    Asserting that developmental growth is easier to attain in developing countries than social change, this paper assesses the prospective impact of biotechnology on the developing nations. Biotechnology is defined as the integrated use of biochemistry, microbiology, and chemical engineering to achieve the industrial processes of fermentation, enzyme…

  13. Educational Linguistics as a Field: A View from Penn's Program on the Occasion of Its 25th Anniversary.

    ERIC Educational Resources Information Center

    Hornberger, Nancy H.

    2001-01-01

    Educational linguistics at the University of Pennsylvania's (Penn) Graduate School of Education traces its beginnings to 1976 and the deanship of Dell Hymes. This paper takes up various aspects of the practice of educational linguistics at Penn, discussing them in relation to issues that have been raised in the literature about the definition,…

  14. A resolution celebrating February 2, 2011, as the 25th anniversary of "National Women and Girls in Sports Day".

    THOMAS, 112th Congress

    Sen. Snowe, Olympia J. [R-ME

    2011-01-27

    Senate - 02/02/2011 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  15. 25th anniversary article: The evolution of electronic skin (e-skin): a brief history, design considerations, and recent progress.

    PubMed

    Hammock, Mallory L; Chortos, Alex; Tee, Benjamin C-K; Tok, Jeffrey B-H; Bao, Zhenan

    2013-11-13

    Human skin is a remarkable organ. It consists of an integrated, stretchable network of sensors that relay information about tactile and thermal stimuli to the brain, allowing us to maneuver within our environment safely and effectively. Interest in large-area networks of electronic devices inspired by human skin is motivated by the promise of creating autonomous intelligent robots and biomimetic prosthetics, among other applications. The development of electronic networks comprised of flexible, stretchable, and robust devices that are compatible with large-area implementation and integrated with multiple functionalities is a testament to the progress in developing an electronic skin (e-skin) akin to human skin. E-skins are already capable of providing augmented performance over their organic counterpart, both in superior spatial resolution and thermal sensitivity. They could be further improved through the incorporation of additional functionalities (e.g., chemical and biological sensing) and desired properties (e.g., biodegradability and self-powering). Continued rapid progress in this area is promising for the development of a fully integrated e-skin in the near future.

  16. 25th anniversary article: Artificial carbonate nanocrystals and layered structural nanocomposites inspired by nacre: synthesis, fabrication and applications.

    PubMed

    Yao, Hong-Bin; Ge, Jin; Mao, Li-Bo; Yan, You-Xian; Yu, Shu-Hong

    2014-01-08

    Rigid biological systems are increasingly becoming a source of inspiration for the fabrication of next generation advanced functional materials due to their diverse hierarchical structures and remarkable engineering properties. Among these rigid biomaterials, nacre, as the main constituent of the armor system of seashells, exhibiting a well-defined 'brick-and-mortar' architecture, excellent mechanical properties, and interesting iridescence, has become one of the most attractive models for novel artificial materials design. In this review, recent advances in nacre-inspired artificial carbonate nanocrystals and layered structural nanocomposites are presented. To clearly illustrate the inspiration of nacre, the basic principles relating to plate-like aragonite single-crystal growth and the contribution of hierarchical structure to outstanding properties in nacre are discussed. The inspiration of nacre for the synthesis of carbonate nanocrystals and the fabrication of layered structural nanocomposites is also discussed. Furthermore, the broad applications of these nacre inspired materials are emphasized. Finally, a brief summary of present nacre-inspired materials and challenges for the next generation of nacre-inspired materials is given.

  17. 25th anniversary article: isoindigo-based polymers and small molecules for bulk heterojunction solar cells and field effect transistors.

    PubMed

    Wang, Ergang; Mammo, Wendimagegn; Andersson, Mats R

    2014-03-26

    Driven by the potential advantages and promising applications of organic solar cells, donor-acceptor (D-A) polymers have been intensively investigated in the past years. One of the strong electron-withdrawing groups that were widely used as acceptors for the construction of D-A polymers for applications in polymer solar cells and FETs is isoindigo. The isoindigo-based polymer solar cells have reached efficiencies up to ∼7% and hole mobilities as high as 3.62 cm(2) V(-1) s(-1) have been realized by FETs based on isoindigo polymers. Over one hundred isoindigo-based small molecules and polymers have been developed in only three years. This review is an attempt to summarize the structures and properties of the isoindigo-based polymers and small molecules that have been reported in the literature since their inception in 2010. Focus has been given only to the syntheses and device performances of those polymers and small molecules that were designed for use in solar cells and FETs. Attempt has been made to deduce structure-property relationships that would guide the design of isoindigo-based materials. It is expected that this review will present useful guidelines for the design of efficient isoindigo-based materials for applications in solar cells and FETs.

  18. 25th anniversary article: Understanding the lithiation of silicon and other alloying anodes for lithium-ion batteries.

    PubMed

    McDowell, Matthew T; Lee, Seok Woo; Nix, William D; Cui, Yi

    2013-09-25

    Alloying anodes such as silicon are promising electrode materials for next-generation high energy density lithium-ion batteries because of their ability to reversibly incorporate a high concentration of Li atoms. However, alloying anodes usually exhibit a short cycle life due to the extreme volumetric and structural changes that occur during lithium insertion/extraction; these transformations cause mechanical fracture and exacerbate side reactions. To solve these problems, there has recently been significant attention devoted to creating silicon nanostructures that can accommodate the lithiation-induced strain and thus exhibit high Coulombic efficiency and long cycle life. In parallel, many experiments and simulations have been conducted in an effort to understand the details of volumetric expansion, fracture, mechanical stress evolution, and structural changes in silicon nanostructures. The fundamental materials knowledge gained from these studies has provided guidance for designing optimized Si electrode structures and has also shed light on the factors that control large-volume change solid-state reactions. In this paper, we review various fundamental studies that have been conducted to understand structural and volumetric changes, stress evolution, mechanical properties, and fracture behavior of nanostructured Si anodes for lithium-ion batteries and compare the reaction process of Si to other novel anode materials.

  19. A resolution celebrating February 2, 2011, as the 25th anniversary of "National Women and Girls in Sports Day".

    THOMAS, 112th Congress

    Sen. Snowe, Olympia J. [R-ME

    2011-01-27

    02/02/2011 Resolution agreed to in Senate without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  20. A resolution congratulating the National Institute of Nursing Research on the occasion of its 25th anniversary.

    THOMAS, 111th Congress

    Sen. Inouye, Daniel K. [D-HI

    2010-09-23

    09/23/2010 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (All Actions) Tracker: This bill has the status Agreed to in SenateHere are the steps for Status of Legislation:

  1. The Anesthesia Patient Safety Foundation at 25: a pioneering success in safety, 25th anniversary provokes reflection, anticipation.

    PubMed

    Eichhorn, John H

    2012-04-01

    The Anesthesia Patient Safety Foundation (APSF) was created in 1985. Its founders coined the term "patient safety" in its modern public usage and created the very first patient safety organization, igniting a movement that is now universal in all of health care. Driven by the vision "that no patient shall be harmed by anesthesia," the APSF has worked tirelessly for more than a quarter century to promote safety education and communication through its widely read Newsletter, its programs, and its presentations. The APSF's extensive research grant program has supported a great many projects leading to key safety improvements and, in particular, was central in the development of high-fidelity mannequin simulation as a research and teaching tool. With its pioneering collaboration, the APSF is unique in incorporating the talents and resources of anesthesia professionals of all types, safety scientists, pharmaceutical and equipment manufacturers, regulators, liability insurance companies, and also surgeons. Specific alerts, campaigns, discussions, and projects have targeted a host of safety issues and dangers over the years, starting with minimal intraoperative monitoring in 1986 and all the way up to beach-chair position cerebral perfusion pressure, operating room medication errors, and the extremely popular DVD on operating room fire safety in 2010; the list is long and expansive. The APSF has served as a model and inspiration for subsequent patient safety organizations and has been recognized nationally as having a dramatic positive impact on the safety of anesthesia care. Recognizing that the work is not over, that systems, organizations, and equipment still at times fail, that basic preventable human errors still do sometimes occur, and that "production pressure" in anesthesia practice threatens past safety gains, the APSF is firmly committed and continues to work hard both on established tenets and new patient safety principles.

  2. The integration of acupuncture within medicine in the UK--the British Medical Acupuncture Society's 25th anniversary.

    PubMed

    Baldry, Peter

    2005-03-01

    Acupuncture was first used in China, probable about 2000 years ago. When acupuncture first arrived in the West in the 17th century, the principles which the Chinese had used to explain its actions were at variance with current scientific knowledge of the body's structure and function. This led to the rejection of acupuncture by the medical profession in the UK, although individual practitioners adopted it with enthusiasm, usually needling the point of maximal tenderness to treat musculoskeletal pain. Acupuncture was more generally accepted in France and Germany, where the pioneering British physician Felix Mann encountered it in the 1950s. He then taught acupuncture to other medical practitioners and organised regular meetings in London, from which the British Medical Acupuncture Society, BMAS, emerged in 1980. The tradition of biannual scientific meetings has continued since then. The Society has many connections with prominent acupuncturists internationally and is a founder member of the International Council of Medical Acupuncture and Related Techniques (ICMART), and has hosted two world congresses. The Society was involved in standardisation of the meridian nomenclature published in 1990. The Society's scientific journal, Acupuncture in Medicine, was founded in 1981 and has gained international recognition, being indexed on several databases. The Society has established regular teaching courses at different levels, which lead to professional qualifications of Certificate and Diploma. The membership is now open to different health professionals, has grown steadily and now stands at nearly 2500. The Society is administered from offices in Cheshire and London. Many individual members have contributed to the Society's characteristic Western 'medical' approach to acupuncture in which needling is seen as a form of neuromuscular stimulation that owes little to traditional meridians or points. The Society has shown a particular interest in acupuncture for myofascial trigger point pain. Members of the Society have contributed to the evidence base of acupuncture with several books, clinical trials and reviews. The Society is optimistic that it will have an increasingly important role in promoting the use and scientific evaluation of acupuncture for the public benefit.

  3. The Role of SoTL in the Academy: Upon the 25th Anniversary of Boyer's "Scholarship Reconsidered"

    ERIC Educational Resources Information Center

    Kern, Beth; Mettetal, Gwendolyn; Dixson, Marcia D.; Morgan, Robin K.

    2015-01-01

    In this essay, we explore definitions and taxonomies of the Scholarship of Teaching and Learning (SoTL) and present a model of the Dimensions of Activities Related to Teaching (DART) which provides a context for SoTL along two dimensions: public/private and systematic/informal. The four quadrants: practice of teaching, sharing about teaching,…

  4. 25th anniversary article: organic photovoltaic modules and biopolymer supercapacitors for supply of renewable electricity: a perspective from Africa.

    PubMed

    Inganäs, Olle; Admassie, Shimelis

    2014-02-12

    The role of materials in civilization is well demonstrated over the centuries and millennia, as materials have come to serve as the classifier of stages of civilization. With the advent of materials science, this relation has become even more pronounced. The pivotal role of advanced materials in industrial economies has not yet been matched by the influence of advanced materials during the transition from agricultural to modern societies. The role of advanced materials in poverty eradication can be very large, in particular if new trajectories of social and economic development become possible. This is the topic of this essay, different in format from the traditional scientific review, as we try to encompass not only two infant technologies of solar energy conversion and storage by means of organic materials, but also the social conditions for introduction of the technologies. The development of organic-based photovoltaic energy conversion has been rapid, and promises to deliver new alternatives to well-established silicon photovoltaics. Our recent development of organic biopolymer composite electrodes opens avenues towards the use of renewable materials in the construction of wooden batteries or supercapacitors for charge storage. Combining these new elements may give different conditions for introduction of energy technology in areas now lacking electrical grids, but having sufficient solar energy inputs. These areas are found close to the equator, and include some of the poorest regions on earth.

  5. Proceedings of the 25th Annual Stirling Physics Meeting 1999

    NASA Astrophysics Data System (ADS)

    McVey, Michael

    1999-09-01

    The 25th Annual Stirling Physics meeting took place on Thursday 20 May on a warm sunny day when the country setting of Stirling Campus could be seen at its best. A total of 225 participants from all sectors of physics education attended. There was an opportunity to view and discuss with exhibitors a wide range of state-of-the-art equipment and teaching materials both before and after the meeting. The theme of the meeting was `Maintaining Standards'. Gemmel Millar, Scottish Branch Secretary acting as Chairperson for the morning session and in anticipation of the first speaker, wondered if a new unit qualification, the `Planck' might be introduced. Half units would then be `Short Plancks' and how many Short Plancks must there be in a unit? Great stuff. Scottish Qualifications Authority Hugh McGill began with a brief history and description of the Scottish Qualifications Authority. Born on 1 April 1997 (a light frisson of amusement swept through the audience) it was a unification between SEB and SCOTVEC and has a range of responsibilities covering schools, further and higher education. It oversees Standard and Higher grades, HNC and HND and SVQs, and it has 500 full-time employees as well as some 13500 appointees who act as examiners, assessors and verifiers etc, without whom its remit could not be carried out. The committee structure of the Board was outlined, one each for national and higher national qualifications and a third for Scottish vocational qualifications. These will be served by a proposed 19 Advisory Groups. The Science Advisory Group will be the key body for advising SQA on strategic developments to ensure that qualifications meet the needs of both client groups and end users. A consultation paper `Added Value To Learning' was referred to, in which all qualifications available in Scotland are given parity of esteem on a rising 11-point scale. Mr McGill stated that standards would be best maintained by ensuring continuity in procedures developed over

  6. Rejuvenation of automotive fuel cells

    SciTech Connect

    Kim, Yu Seung; Langlois, David A.

    2016-08-23

    A process for rejuvenating fuel cells has been demonstrated to improve the performance of polymer exchange membrane fuel cells with platinum/ionomer electrodes. The process involves dehydrating a fuel cell and exposing at least the cathode of the fuel cell to dry gas (nitrogen, for example) at a temperature higher than the operating temperature of the fuel cell. The process may be used to prolong the operating lifetime of an automotive fuel cell.

  7. Hypothetical Rejuvenated Planets Artist Concept

    NASA Image and Video Library

    2015-06-25

    This artist's concept shows a hypothetical "rejuvenated" planet -- a gas giant that has reclaimed its youthful infrared glow. NASA's Spitzer Space Telescope found tentative evidence for one such planet around a dead star, or white dwarf, called PG 0010+280 (depicted as white dot in illustration). When planets are young, they are warm and toasty due to internal heat left over from their formation. Planets cool over time -- until they are possibly rejuvenated. The theory goes that this Jupiter-like planet, which orbits far from its star, would accumulate some of the material sloughed off by its star as the star was dying. The material would cause the planet to swell in mass. As the material fell onto the planet, it would heat up due to friction and glow with infrared light. The final result would be an old planet, billions of years in age, radiating infrared light as it did in its youth. Spitzer detected an excess infrared light around the white dwarf PG 0010+280. Astronomers aren't sure where the light is coming from, but one possibility is a rejuvenated planet. Future observations may help solve the mystery. A Jupiter-like planet is about ten times the size of a white dwarf. White dwarfs are about the size of Earth, so one white dwarf would easily fit into the Great Red Spot on Jupiter! http://photojournal.jpl.nasa.gov/catalog/PIA19346

  8. Rejuvenation and Memory in Model Spin Glasses

    NASA Astrophysics Data System (ADS)

    Jiménez, S.; Martín-Mayor, V.; Pérez-Gaviro, S.

    We study memory and rejuvenation effects in Isingspin-glasses in 3 and 4 dimensions. In D=3, 1000 times larger than in previous work are reached using the SUE machine. Memory and rejuvenation are found in a 2 temperatures cycle. Similar effects are reported for the site-diluted Ising model (without chaos). However, rejuvenation is reduced if off-equilibrium corrections to the fluctuation-dissipation theorem are considered. Memory and rejuvenation are describable in terms of the growth-regime of a coherence-length.

  9. Suicide around anniversary times.

    PubMed

    Barker, Emma; O'Gorman, John G; De Leo, Diego

    2014-01-01

    The anniversary of the loss of a loved one is known to induce negative emotions, which for some can be significant. The present study examined the incidence of suicide around the time of such anniversaries using data from the Queensland Suicide Register for the years 1998 to 2008. There were statistically significant increases in suicide events immediately after the loss of a loved one and around the anniversary of the loss. Limitations of the study are noted.

  10. Esthetic rejuvenation of the temple.

    PubMed

    Rose, Amy E; Day, Doris

    2013-01-01

    Loss of volume in the temples is an early sign of aging that is often overlooked by both the physician and the patient. Augmentation of the temple using soft tissue fillers improves the contours of the upper face with the secondary effect of lengthening and lifting the lateral brow. After replacement of volume, treatment of the overlying skin with skin-tightening devices or laser resurfacing help to complete a comprehensive rejuvenation of the temple and upper one-third of the face. Copyright © 2013 Elsevier Inc. All rights reserved.

  11. Ageing, neurodegeneration and brain rejuvenation

    PubMed Central

    2016-01-01

    Although systemic diseases take the biggest toll on human health and well-being, increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the essence of being. Ageing, which is fundamental to neurodegeneration and dementia, affects every organ in the body and seems to be encoded partly in a blood-based signature. Indeed, factors in the circulation have been shown to modulate ageing and to rejuvenate numerous organs, including the brain. The discovery of such factors, the identification of their origins and a deeper understanding of their functions is ushering in a new era in ageing and dementia research. PMID:27830812

  12. 25th U.S. Department of Agriculture interagency research forum on invasive species [proceedings

    Treesearch

    Katherine A. McManus; Kurt W., comps. Gottschalk

    2014-01-01

    This meeting was the 25th in a series of annual USDA Interagency Research Forums that are sponsored by the Forest Service, Animal and Plant Health Inspection Service, National Institute of Food and Agriculture, and Agriculture Research Service. The Group's original goal of fostering communication and providing a forum for the overview of ongoing research among the...

  13. Editorial: Special issue highlighting research presented at the 25th IWGO Conference, Chicago 2014

    USDA-ARS?s Scientific Manuscript database

    A joint international conference was held among corn insect entomologists from 15 countries at the Allerton Hotel, Chicago, Illinois on April 13-17, 2014. It combined the 25th IWGO (International Working Group on Ostrinia and other maize pests) Conference with the 4th Diabrotica Genetics Conference,...

  14. Mosquito vector biology and control in Latin America - A 25th Symposium

    USDA-ARS?s Scientific Manuscript database

    The 25th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 81st Annual Meeting in New Orleans, LA, in March 2015. The principal objective, for the previous 24 symposia, was to promote participation in the AMCA by vector control spec...

  15. 50th anniversary logo

    NASA Image and Video Library

    2011-03-02

    John C. Stennis Space Center is celebrating its 50th anniversary in 2011. NASA announced plans to build a rocket engine test facility in Hancock County, Miss., on Oct. 25, 1961. A new anniversary logo highlights the theme of the anniversary year - celebrating Stennis as a unique federal city and its five decades of powering America's space dreams. Stennis is home to more than 30 federal, state, academic and private organizations and several technology-based companies. In addition to testing Apollo Program rocket stages that carried humans to the moon, Stennis tested every main engine used in more than 130 space shuttle flights.

  16. Research activities on Antarctic middle atmosphere by JARE 25th team

    NASA Technical Reports Server (NTRS)

    Hirasawa, T.; Eiwasaka, Y. AFTANAKA, M. agfujii, r.0 typ; Eiwasaka, Y. AFTANAKA, M. agfujii, r.0 typ

    1985-01-01

    The Antarctic Middle Atmosphere (AMA)-Japan research project was set about by the JARE (Japan Antarctic Research Expedition) 23rd team in 1982, and since then the JARE-24th and JARE-25th teams have been continuing reseach on the Antarctic Middle Atmosphere. Results gained by JARE-25th team members who are now working at Syowa Station (69.99 deg S, 39.35 deg E), Antarctica are presented. In their activities satellite measurements (Exos-C) and rocket soundings are used. Three rockets of the S310 type were launched at Syowa Station (Geomagnetic Latitude = 69.9 deg S) for the purpose of directly observing the electron density, ionospheric temperature, auroral patterns and luminosity in situ. Vertical profiles of electron density and auroral emission 4278A measured by three rockets are compared.

  17. Research activities on Antarctic middle atmosphere by JARE 25th team

    NASA Technical Reports Server (NTRS)

    Hirasawa, T.; Eiwasaka, Y. AFTANAKA, M. agfujii, r.0 typ; Eiwasaka, Y. AFTANAKA, M. agfujii, r.0 typ

    1985-01-01

    The Antarctic Middle Atmosphere (AMA)-Japan research project was set about by the JARE (Japan Antarctic Research Expedition) 23rd team in 1982, and since then the JARE-24th and JARE-25th teams have been continuing reseach on the Antarctic Middle Atmosphere. Results gained by JARE-25th team members who are now working at Syowa Station (69.99 deg S, 39.35 deg E), Antarctica are presented. In their activities satellite measurements (Exos-C) and rocket soundings are used. Three rockets of the S310 type were launched at Syowa Station (Geomagnetic Latitude = 69.9 deg S) for the purpose of directly observing the electron density, ionospheric temperature, auroral patterns and luminosity in situ. Vertical profiles of electron density and auroral emission 4278A measured by three rockets are compared.

  18. In the 25th year of bioethics publishing: new challenges of the post-truth era.

    PubMed

    Jesani, Amar

    2017-01-01

    As IJME enters its 25th year of publication, all of us closely associated with the journal look back on this journey with a degree of satisfaction. Not only has the only bioethics journal published from India survived for 24 years, it has also produced some extraordinary successes. As you read this issue, we will be celebrating the 12th year of the biennial National Bioethics Conferences - the sixth NBC will take place in Pune from January 13 to 15, 2017.

  19. Philosophy of Education in Cultural Perspective. Essays Commemorating the Twenty-Fifth Anniversary Celebration of the Far Western Philosophy of Education Society.

    ERIC Educational Resources Information Center

    Jelinek, James John, Ed.

    The manuscript contains 48 essays commemorating the 25th anniversary of the Far Western Philosophy of Education Society. Topics included are cultural awareness; the teaching of values; philosophy and teacher education; humanistic education; existentialism and education; the nature of man; and the educational philosophies of Abraham J. Heschel,…

  20. Philosophy of Education in Cultural Perspective. Essays Commemorating the Twenty-Fifth Anniversary Celebration of the Far Western Philosophy of Education Society.

    ERIC Educational Resources Information Center

    Jelinek, James John, Ed.

    The manuscript contains 48 essays commemorating the 25th anniversary of the Far Western Philosophy of Education Society. Topics included are cultural awareness; the teaching of values; philosophy and teacher education; humanistic education; existentialism and education; the nature of man; and the educational philosophies of Abraham J. Heschel,…

  1. REPORT FROM THE ORGANIZERS: The 25th International Conference on Low Temperature Physics

    NASA Astrophysics Data System (ADS)

    Kes, Peter

    2009-03-01

    The 25th International Conference on Low Temperature Physics (LT25) was hosted by the Kamerlingh Onnes Laboratorium of the Leiden Institute of Physics and held in the RAI Convention Center in Amsterdam, The Netherlands, 6-13 August 2008. It was the second time that the Kamerlingh Onnes Laboratory had the privilege of organizing an LT conference. In 1958, at LT6, 50 years of liquid helium temperatures were commemorated; in 2008 we celebrated the 100th anniversary of the remarkable achievements of Heike Kamerlingh Onnes and his collaborators in Leiden. In 1958 there were 323 participants and 145 papers appeared in the proceedings; in 2008 these numbers had increased to 1390 participants and 900 papers, of which eventually 849 were accepted. This large participation required adequate conference and housing facilities. These could not be found in Leiden, but were conveniently available in Amsterdam. The triennial International Low Temperature Conferences are organized under the auspices of the International Union of Pure and Applied Physics (IUPAP) through Commission C5 on Low Temperature Physics. It is the most important global meeting that brings together the international scientific community in the broad field of Low Temperature Physics. Because the meeting is held only every third year the 11 plenary and 22 half plenary talks (of 45 or 30 min.) generally provide an overview of important new discoveries over the last few years, whereas the 161 short oral presentations (20 min.) are mainly focused on very recent developments. Since the field is broad, embracing a large section of condensed matter physics, the program is divided into five parallel program lines: A. Quantum Gases, Fluids and Solids B. Superconductivity C. Quantum Phase Transitions and Magnetism D. Electronic Quantum Transport in Condensed Matter E. Cryogenic Techniques and Applications This distinction was used both to group the 1625 accepted abstracts, and the short-oral and poster presentations; the

  2. Niacin: an old drug rejuvenated.

    PubMed

    Kamanna, Vaijinath S; Ganji, Shobha H; Kashyap, Moti L

    2009-01-01

    Niacin has long been used in the treatment of dyslipidemia and cardiovascular disease. Recent research on niacin has been focused on understanding the mechanism of action of niacin and preparation of safer niacin formulations. New findings indicate that niacin does the following: 1) it inhibits hepatic diacylglycerol acyltransferase 2, resulting in inhibition of triglyceride synthesis and decreased apolipoprotein B-containing lipoproteins; 2) it decreases the surface expression of hepatic adenosine triphosphate synthase beta-chain, leading to decreased holoparticle high-density lipoprotein catabolism and increased high-density lipoprotein levels; and 3) it increases redox potential in arterial endothelial cells, resulting in inhibition of redox-sensitive genes. Flushing, an adverse effect of niacin, results from niacin receptor GPR109A-mediated production of prostaglandin D2 and E2 via DP1 and EP2/4 receptors. DP1 receptor antagonist (laropiprant) attenuates the niacin flush. A reformulated preparation of extended-release niacin (Niaspan; Abbott, Abbott Park, IL) lowers flushing compared with an older Niaspan formulation. These advancements in niacin research have rejuvenated its use for the treatment of dyslipidemia and cardiovascular disease.

  3. Predictions of the onset of mini ice age in the 25th solar cycle

    NASA Astrophysics Data System (ADS)

    Kumar, Rajiv

    2016-07-01

    Predictions of the ir-regularty in the 11 year heartbeat of the sun due to asyncronous of the two layered dynamo effect would result in mini ice age as in the Maunder minimum.The onset of this event is expected in the begining of 25th solar cycle and would go to its maximum in the 26th solar cycle.The minimum temperature is expected in 2028 due to the fall of solar activity by 60 % termed as solar hibernation.The predictions are based on the observations obtained by the Royal Greenwich observatory since 1874. Keywords: Dynamo effect,munder minimum,Solar hybernation

  4. Vaginal Rejuvenation with Gore-Mycromesh.

    PubMed

    Park, Tae Hwan; Whang, Kwi Whan

    2015-08-01

    Recently, we introduced functional vaginal rejuvenation with elastic silicone threads. However, some patients with specific indications need other biocompatible materials for rejuvenation of the vagina. Gore-Mycromesh is one of the most commonly used materials in plastic and reconstructive surgical fields and it is composed of expanded poly-tetrafluroethylene. In this study, we introduced our clinical experience with static vaginal rejuvenation using Gore-Mycromesh to specifically assess the overall patient satisfaction (Female Sexual Function Index, FSFI). This study included 50 patients who underwent vaginal rejuvenation with a Gore-Mycromesh between 2010 and 2012. After marking two incisions at the inner side of the vaginal inlet and posterior wall, respectively, we performed submucosal dissection at the posterior vaginal wall and then grafted and secured a Gore-Mycromesh to the dissected area (muscle/fascia). Overall the FSFI improved as time progressed up to a year postoperatively. This is especially prominent in the FSFI satisfaction subscore. All but eight patients (42/50, 84 %) were "very satisfied (5)" or "satisfied (4)" with the outcomes after the vaginal rejuvenation. The overall complication rate was 8 %. Based on our clinical experience with the 50 cases, we think that vaginal rejuvenation with Gore-Mycromesh significantly improved postoperative outcomes, resulting in improved sexual function with a focus on improving the FSFI satisfaction subscore in mid-term follow-up. Elderly patients experience better outcomes using gore mycromesh rather than silicone thread because we can plicate the vaginal posterior wall with senile changes simultaneously using an open technique. However, further studies would be warranted for better positioning and adherence of grafted implants to surrounding tissue and for increasing the tightening effect of the implant and its sufficient longevity.

  5. Diamond Anniversary Lecture Series.

    ERIC Educational Resources Information Center

    Adams, Dewey A.; And Others

    This document contains the texts of four lectures that were presented as part of a series commemorating the 75th anniversary of Ohio State University's Department of Agricultural Education. The first lecture, "The Conceptualization Process and Vocational Education Management," (Dewey A. Adams) discusses a five-step management behavior approach for…

  6. Curiosity Rover's First Anniversary

    NASA Image and Video Library

    2013-08-06

    Expedition 35/36 NASA astronaut Karen Nyberg, right on screen, is seen on a live feed from the International Space Station as they participate in a public event at NASA Headquarters observing the first anniversary of the Curiosity rover's landing on Mars, Tuesday, August 6th, 2013 in Washington. Photo Credit: (NASA/Carla Cioffi)

  7. Curiosity Rover's First Anniversary

    NASA Image and Video Library

    2013-08-06

    Expedition 35/36 NASA astronaut Chris Cassidy, left on screen, is seen on a live feed from the International Space Station as they participate in a public event at NASA Headquarters observing the first anniversary of the Curiosity rover's landing on Mars, Tuesday, August 6th, 2013 in Washington. Photo Credit: (NASA/Carla Cioffi)

  8. Exceptional Volumes of Rejuvenated Volcanism in Samoa

    NASA Astrophysics Data System (ADS)

    Konter, J. G.; Jackson, M.; Storm, L.

    2010-12-01

    The internal structure of within-plate volcanoes is typically compared to the stages of volcanic evolution in Hawaii. In Samoa, these stages show some differences with the Hawaiian model, in terms of the duration, volume and geochemical composition of the stages. Particularly, the rejuvenated stage of volcanism in Samoa is significantly more voluminous, with increasing geographic coverage with age, completely repaving the island of Savai’i. This unusual outpouring of rejuvenated lavas has previously been proposed to be related to the tectonic setting, near the northern terminus of the Tonga Trench. Therefore, Samoan volcanism might be caused by lithospheric fracturing, a mantle plume, or potentially a combination of the two. We collected new samples from a deeply eroded canyon on Savai’i to determine a time evolution of the transition from shield to eventual rejuvenated lavas. The canyon exposes several hundred meters of lavas, and we collected samples about 200m vertically down into the canyon. These samples are dominantly olivine basalts, and their Pb isotope compositions fall within the compositional field of young rejuvenated lavas on Savai’i and Upolu. This canyon section, therefore, represents a minimum thickness for the rejuvenated lavas of 200m. Assuming eruption of rejuvenated lavas only occurred subaerially, with a universal thickness of 200m, the new data suggest more than one percent of the volume of Savai’i consists of rejuvenated lavas. This is an order of magnitude greater than the largest relative volumes in Hawaii (Kauai), and implies a different cause for rejuvenated volcanism in Samoa. Another feature that suggests different processes may be important is the transition between the shield and rejuvenated stage. Although Samoan volcanoes do not seem to erupt exactly the same rock types as characteristic Hawaiian post-shield stage lavas, there is a definite shift to more evolved compositions (including trachytes) during the later stages of

  9. [Friedrich Nietzsche: history of his illness. On the 100th anniversary of the death of the poet-philosopher].

    PubMed

    Wilkes, J

    2000-04-01

    The philosopher Friedrich Nietzsche was one of the most famous patients in the psychiatric hospital Jena. Between 1889 and 1890, Otto Binswanger und Theodor Ziehen treated the progressive paralysis of Friedrich Nietzsche whose 100th anniversary of death is on 25th August 2000. After Nietzsche's death, an animated discussion about his disease arose. Many objected against the syphilitic diagnosis of the disease. Nietzsche's medical fill became a popular object of science, although it ended as a very odd story.

  10. Ten Summer Rejuvenators for School Counselors.

    ERIC Educational Resources Information Center

    McCormick, John F.

    1998-01-01

    Ten activities for personal and professional rejuvenation include: refurbish your office; purge, condense, and create new files; update scholarship information; visit a university library; enhance your expertise; set a few workable goals; prepare for future expenditures; evaluate new guidance software; consult with grant-seeking experts; and write…

  11. Mosquito Vector Biology and Control in Latin America-A 25TH Symposium.

    PubMed

    2015-09-01

    The 25th Annual Latin American Symposium presented by the American Mosquito Control Association (AMCA) was held as part of the 81st Annual Meeting in New Orleans, LA, in March 2015. The principal objective, as for the previous 24 symposia, was to promote participation in the AMCA by vector control specialists, public health workers, and academicians from Latin America. This publication includes summaries of 24 presentations that were given orally in Spanish by participants from Colombia, Mexico, and the USA. Topics addressed in the symposium included: surveillance, operations, ecology, chemical control, studies of dengue viruses, and insecticide resistance. Insect vectors included Aedes, Culex, and Anopheles mosquitoes in addition to phlebotomine sand flies and triatomine bugs.

  12. The Daylight Bolide of 1996 April 25th , over Mt. Bruce, New Zealand

    NASA Astrophysics Data System (ADS)

    Wolf, G.; McBeath, A.

    On Thursday, 1996 April 25th (ANZAC Day in New Zealand) a bright daylight bolide with possible -22m end point, was seen from Newtown, Wellington, New Zealand at 02h20m12s. Its end-point altitude was calculated to be app. 15-20km over Mt. Bruce, some 80km NE of Wellington. A smoky train, initially 42deg long, was visible to the naked eye for 28 minutes afterwards. Sonics were heard by the New Zealand author, around 265s after the end point, suggesting a direct-line distance of 88km from the author's location. The impact point was probably several kilometers off Foxton Beach in the Tasman Sea. The bolide passed about 5deg above the first quarter Moon, and two photographs were secured, showing how the train began to drift, ultimately app. 17deg, to the south, before dissipating.

  13. Star Trek Anniversary Greeting

    NASA Image and Video Library

    2016-08-26

    All Goddard employees are invited to gather in Bldg 28 Friday, August 26, 2016 to share a greeting in recognition of Star Trek 50th anniversary which is Sept 8. Office of Communications will film people speaking several lines in unison. Video will be part of a longer video of messages recorded across the agency and will be shared on social media via Dateline, Facebook and Twitter.

  14. Rejuvenation: an integrated approach to regenerative medicine.

    PubMed

    Kang, Y James; Zheng, Lily

    2013-12-01

    The word "rejuvenate" found in the Merriam-Webster dictionary is (1) to make young or youthful again: give new vigor to, and (2) to restore to an original or new state. Regenerative medicine is the process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects. To accomplish this, approaches including transplantation, tissue engineering, cell therapy, and gene therapy are brought into action. These all use exogenously prepared materials to forcefully mend the failed organ. The adaptation of the materials in the host and their integration into the organ are all uncertain. It is a common sense that tissue injury in the younger is easily repaired and the acute injury is healed better and faster. Why does the elder have a diminished capacity of self-repairing, or why does chronic injury cause the loss of the self-repairing capacity? There must be some critical elements that are involved in the repair process, but are suppressed in the elder or under the chronic injury condition. Rejuvenation of the self-repair mechanism would be an ideal solution for functional recovery of the failed organ. To achieve this, it would involve renewal of the injury signaling, reestablishment of the communication and transportation system, recruitment of the materials for repairing, regeneration of the failed organ, and rehabilitation of the renewed organ. It thus would require a comprehensive understanding of developmental biology and a development of new approaches to activate the critical players to rejuvenate the self-repair mechanism in the elder or under chronic injury condition. Efforts focusing on rejuvenation would expect an alternative, if not a better, accomplishment in the regenerative medicine.

  15. Structural rejuvenation in bulk metallic glasses

    DOE PAGES

    Tong, Yang; Iwashita, T.; Dmowski, Wojciech; ...

    2015-01-05

    Using high-energy X-ray diffraction we study structural changes in bulk metallic glasses after uniaxial compressive homogeneous deformation at temperatures slightly below the glass transition. We observe that deformation results in structural disordering corresponding to an increase in the fictive, or effective, temperature. However, the structural disordering saturates after yielding. Lastly, examination of the experimental structure and molecular dynamics simulation suggests that local changes in the atomic connectivity network are the main driving force of the structural rejuvenation.

  16. A Software Rejuvenation Framework for Distributed Computing

    NASA Technical Reports Server (NTRS)

    Chau, Savio

    2009-01-01

    A performability-oriented conceptual framework for software rejuvenation has been constructed as a means of increasing levels of reliability and performance in distributed stateful computing. As used here, performability-oriented signifies that the construction of the framework is guided by the concept of analyzing the ability of a given computing system to deliver services with gracefully degradable performance. The framework is especially intended to support applications that involve stateful replicas of server computers.

  17. Impact on facial rejuvenation with dermatological preparations

    PubMed Central

    Bowler, Patrick J

    2009-01-01

    The treatment options for facial rejuvenation using dermatological, nonsurgical techniques have dramatically increased in the past 10 years. This follows the introduction of botulinum toxin and a variety of dermal fillers. The public interest in noninvasive treatments has changed the market beyond recognition with more physicians involved in providing services to satiate the demand. The impact on the public and medical profession is discussed. PMID:19503770

  18. J85 Rejuvenation Through Technology Insertion

    DTIC Science & Technology

    2000-10-01

    and Sabre 75 business addition to military production, the J85 was jets . Number Model Produced Aircraft Type(s) Engine Type Thrust (lbs) J85-GE-4 740...REJUVENATION THROUGH TECHNOLOGY INSERTION T.A. Brisken, P.N. Howell, A.C. Ewing Military Engines Operation GE Aircraft Engines 1 Neumann Way Cincinnati...OH 45215, USA Summary thrust to weight ratio turbojet engines with potential application to early cruise missiles and drones. The history of the

  19. Structural rejuvenation in bulk metallic glasses

    SciTech Connect

    Tong, Yang; Iwashita, T.; Dmowski, Wojciech; Bei, Hongbin; Yokoyama, Y.; Egami, Takeshi

    2015-01-05

    Using high-energy X-ray diffraction we study structural changes in bulk metallic glasses after uniaxial compressive homogeneous deformation at temperatures slightly below the glass transition. We observe that deformation results in structural disordering corresponding to an increase in the fictive, or effective, temperature. However, the structural disordering saturates after yielding. Lastly, examination of the experimental structure and molecular dynamics simulation suggests that local changes in the atomic connectivity network are the main driving force of the structural rejuvenation.

  20. A brief history of rejuvenation operations.

    PubMed

    Kozminski, Michael A; Bloom, David A

    2012-03-01

    We discuss the place in history of operative procedures for hormonal rejuvenation. The scientific and historical literature was reviewed. In the early 20th century, building on the earlier work of Berthold and Brown-Séquard, Eugen Steinach developed a combination of vasectomy and vasoligature that became known as the Steinach operation. This procedure, along with testicular implantation popularized by Serge Voronoff, was an attempt to rejuvenate older and fatigued men around the world. The early experiments and results of Steinach, Voronoff and their followers were plagued by secrecy, subjectivity and sensationalism in an effort to produce the most scientific data. These rejuvenists used their results to outcompete one another. Ultimately the lack of verifiable outcome data and the chemical isolation of the "internal secretion" (testosterone) ended this era in surgery. Always a work in progress, the practice of medicine has been guided by human curiosity with trial, error and success. History records aberrant paths along the way and the rejuvenation movement was one such journey. While superseded by later knowledge, the efforts of the rejuvenists comprise an interesting chapter in the development of urology, endocrinology and transplant surgery. Copyright © 2012 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

  1. Effect of rejuvenation hormones on spermatogenesis.

    PubMed

    Moss, Jared L; Crosnoe, Lindsey E; Kim, Edward D

    2013-06-01

    To review the current literature for the effect of hormones used in rejuvenation clinics on the maintenance of spermatogenesis. Review of published literature. Not applicable. Men who have undergone exogenous testosterone (T) and/or anabolic androgenic steroid (AAS) therapies. None. Semen analysis, pregnancy outcomes, and time to recovery of spermatogenesis. Exogenous testosterone and anabolic androgenic steroids suppress intratesticular testosterone production, which may lead to azoospermia or severe oligozoospermia. Therapies that protect spermatogenesis involve human chorionic gonadotropin (hCG) therapy and selective estrogen receptor modulators (SERMs). The studies examining the effect of human growth hormone (HGH) on infertile men are uncontrolled and unconvincing, but they do not appear to negatively impact spermatogenesis. At present, routine use of aromatase inhibitors is not recommended based on a lack of long-term data. The use of hormones for rejuvenation is increasing with the aging of the Baby Boomer population. Men desiring children at a later age may be unaware of the side-effect profile of hormones used at rejuvenation centers. Testosterone and anabolic androgenic steroids have well-established detrimental effects on spermatogenesis, but recovery may be possible with cessation. Clomiphene citrate, human growth hormone (HGH)/insulin-like growth factor-1 (IGF-1), human chorionic gonadotropin (hCG), and aromatase inhibitors do not appear to have significant negative effects on sperm production, but quality data are lacking. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  2. Teaching Biochemistry at Lisbon University--Facing the Challenge of the Bologna Declaration in the 25th Anniversary of the Biochemistry Course

    ERIC Educational Resources Information Center

    Farinha, Carlos M.; Freire, Ana Ponces

    2007-01-01

    The biochemistry degree has been taught at Lisbon University for 25 years. Since its creation, the curriculum is characterized for being widely eclectic and multidisciplinary. The adoption of the concepts proposed in Europe by the Declaration of Bologna and incorporation of these ideas at Lisbon University is discussed here for the biochemistry…

  3. The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters.

    PubMed

    Golin, John; Ambudkar, Suresh V

    2015-05-01

    Asymmetric ABC (ATP-binding cassette) transporters make up a significant proportion of this important superfamily of integral membrane proteins. These proteins contain one canonical (catalytic) ATP-binding site and a second atypical site with little enzymatic capability. The baker's yeast (Saccharomyces cerevisiae) Pdr5 multidrug transporter is the founding member of the Pdr subfamily of asymmetric ABC transporters, which exist only in fungi and slime moulds. Because these organisms are of considerable medical and agricultural significance, Pdr5 has been studied extensively, as has its medically important homologue Cdr1 from Candida albicans. Genetic and biochemical analyses of Pdr5 have contributed important observations that are likely to be applicable to mammalian asymmetric ABC multidrug transporter proteins, including the basis of transporter promiscuity, the function of the non-catalytic deviant ATP-binding site, the most complete description of an in vivo transmission interface, and the recent discovery that Pdr5 is a molecular diode (one-way gate). In the present review, we discuss the observations made with Pdr5 and compare them with findings from clinically important asymmetric ABC transporters, such as CFTR (cystic fibrosis transmembrane conductance regulator), Cdr1 and Tap1/Tap2.

  4. Land Processes Distributed Active Archive Center (LP DAAC) 25th Anniversary Recognition "A Model for Government Partnerships". LP DAAC "History and a Look Forward"

    NASA Technical Reports Server (NTRS)

    Behnke, Jeanne; Doescher, Chris

    2015-01-01

    This presentation discusses 25 years of interactions between NASA and the USGS to manage a Land Processes Distributed Active Archive Center (LPDAAC) for the purpose of providing users access to NASA's rich collection of Earth Science data. The presentation addresses challenges, efforts and metrics on the performance.

  5. Honoring the 25th anniversary of the enactment of the Drug Price Competition and Patent Term Restoration Act of 1984 (the Hatch-Waxman Act).

    THOMAS, 111th Congress

    Sen. Brown, Sherrod [D-OH

    2009-09-24

    09/24/2009 Referred to the Committee on the Judiciary. (text of measure as introduced: CR S9853) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Promoting Excellence through Information and Technology. General Session Presentations of the Anniversary Forum of the Association for Institutional Research (25th, Portland, Oregon, April 28-May 1, 1985).

    ERIC Educational Resources Information Center

    Dickey, Ann K., Ed.

    The evolving profession of institutional research as it exists in 1985, historical antecedents, and ideas about possible futures are presented in two addresses, a panel discussion, and an awards program from the Association for Institutional Research's annual forum. In "Promoting Excellence: Pursuing the Challenge of Quality," Burton R.…

  7. "25 Years of Educational Excellence." Special Issue Commemorating the 25th Anniversary of the Journal of the Pennsylvania Black Conference on Higher Education, Inc.

    ERIC Educational Resources Information Center

    Redfern, Alicia King, Ed.

    1996-01-01

    The articles in this document are intended to be reflective of the theme "A Silver Celebration: 25 Years of Educational Excellence," and cover topics ranging from black college athletes to black real estate owners to the status of African Americans in Pennsylvania colleges and universities. They include: "The Social and Political…

  8. 25th anniversary article: what can be done with the Langmuir-Blodgett method? Recent developments and its critical role in materials science.

    PubMed

    Ariga, Katsuhiko; Yamauchi, Yusuke; Mori, Taizo; Hill, Jonathan P

    2013-12-03

    The Langmuir-Blodgett (LB) technique is known as an elegant method for fabrication of well-defined layered structures with molecular level precision. Since its discovery the LB method has made an indispensable contribution to surface science, physical chemistry, materials chemistry and nanotechnology. However, recent trends in research might suggest the decline of the LB method as alternate methods for film fabrication such as layer-by-layer (LbL) assembly have emerged. Is LB film technology obsolete? This review is presented in order to challenge this preposterous question. In this review, we summarize recent research on LB and related methods including (i) advanced design for LB films, (ii) LB film as a medium for supramolecular chemistry, (iii) LB technique for nanofabrication and (iv) LB involving advanced nanomaterials. Finally, a comparison between LB and LbL techniques is made. The latter reveals the crucial role played by LB techniques in basic surface science, current advanced material sciences and nanotechnologies. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. 25th anniversary article: galvanic replacement: a simple and versatile route to hollow nanostructures with tunable and well-controlled properties.

    PubMed

    Xia, Xiaohu; Wang, Yi; Ruditskiy, Aleksey; Xia, Younan

    2013-11-26

    This article provides a progress report on the use of galvanic replacement for generating complex hollow nanostructures with tunable and well-controlled properties. We begin with a brief account of the mechanistic understanding of galvanic replacement, specifically focused on its ability to engineer the properties of metal nanostructures in terms of size, composition, structure, shape, and morphology. We then discuss a number of important concepts involved in galvanic replacement, including the facet selectivity involved in the dissolution and deposition of metals, the impacts of alloying and dealloying on the structure and morphology of the final products, and methods for promoting or preventing a galvanic replacement reaction. We also illustrate how the capability of galvanic replacement can be enhanced to fabricate nanomaterials with complex structures and/or compositions by coupling with other processes such as co-reduction and the Kirkendall effect. Finally, we highlight the use of such novel metal nanostructures fabricated via galvanic replacement for applications ranging from catalysis to plasmonics and biomedical research, and conclude with remarks on prospective future directions.

  10. The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters

    PubMed Central

    Golin, John; Ambudkar, Suresh V.

    2016-01-01

    Asymmetric ABC (ATP-binding cassette) transporters make up a significant proportion of this important superfamily of integral membrane proteins. These proteins contain one canonical (catalytic) ATP-binding site and a second atypical site with little enzymatic capability. The baker’s yeast (Saccharomyces cerevisiae) Pdr5 multidrug transporter is the founding member of the Pdr subfamily of asymmetric ABC transporters, which exist only in fungi and slime moulds. Because these organisms are of considerable medical and agricultural significance, Pdr5 has been studied extensively, as has its medically important homologue Cdr1 from Candida albicans. Genetic and biochemical analyses of Pdr5 have contributed important observations that are likely to be applicable to mammalian asymmetric ABC multidrug transporter proteins, including the basis of transporter promiscuity, the function of the non-catalytic deviant ATP-binding site, the most complete description of an in vivo transmission interface, and the recent discovery that Pdr5 is a molecular diode (one-way gate). In the present review, we discuss the observations made with Pdr5 and compare them with findings from clinically important asymmetric ABC transporters, such as CFTR (cystic fibrosis transmembrane conductance regulator), Cdr1 and Tap1/Tap2. PMID:25886173

  11. Recruiting Trends 1995-96. A Study of 527 Businesses, Industries, and Governmental Agencies Employing New College Graduates. 25th Anniversary Edition.

    ERIC Educational Resources Information Center

    Scheetz, L. Patrick

    This study sought to determine recruiting trends of business, industry, and government among the pool of new college graduates. Questionnaires were mailed to 4,072 employers, of which 507 returned complete responses. The survey found that new college graduates of 1995-96 can expect mild growth in job opportunities. For the third consecutive year,…

  12. Approximation of periodicity in sunspot formation of and prediction of the 25th cycle

    NASA Astrophysics Data System (ADS)

    Roshchina, E. M.; Sarychev, A. P.

    2015-12-01

    The empirical parameters of functions approximating solar activity cycles 8-23 are used. These parameters show the position of the cycle on the time axis (the start time) and its shape, which is characterized by the extension along the time axes and activity index. A statistical connections was found between two shape parameters of the cycle (the so-called Waldmeier effect) and between the extension of the cycle growth branch and the start time of the following cycle. A connection between the parameters of the given and future cycles has been obtained for a function approximating the "secular" variations in the cycle amplitude. The aforementioned empirical relationships can be stated in the form of three equations that contain the parameters of the current and future cycles. Solving this system, we obtain estimates for three parameters of the function approximating the next cycle. For the 25th cycle, it was found that the maximum of the smoothed Wolf number 116 is expected in March/April 2026; the duration of the activity growth branch is 4.16 years.

  13. Proceedings of the 25th Seismic Research Review -- Nuclear Explosion Monitoring: Building the Knowledge Base

    SciTech Connect

    Chavez, Francesca C.; Mendius, E. Louise

    2003-09-23

    These proceedings contain papers prepared for the 25th Seismic Research Review -- Nuclear Explosion Monitoring: Building the Knowledge Base, held 23-25 September, 2003 in Tucson, Arizona. These papers represent the combined research related to ground-based nuclear explosion monitoring funded by the National Nuclear Security Administration (NNSA), Defense Threat Reduction Agency (DTRA), Air Force Research Laboratory (AFRL), US Army Space and Missile Defense Command, and other invited sponsors. The scientific objectives of the research are to improve the United States capability to detect, locate, and identify nuclear explosions. The purpose of the meeting is to provide the sponsoring agencies, as well as potential users, an opportunity to review research accomplished during the preceding year and to discuss areas of investigation for the coming year. For the researchers, it provides a forum for the exchange of scientific information toward achieving program goals, and an opportunity to discuss results and future plans. Paper topics include: seismic regionalization and calibration; detection and location of sources; wave propagation from source to receiver; the nature of seismic sources, including mining practices; hydroacoustic, infrasound, and radionuclide methods; on-site inspection; and data processing.

  14. Curiosity Rover's First Anniversary

    NASA Image and Video Library

    2013-08-06

    A small-scaled model of NASA's Curiosity rover is seen at a public event observing the first anniversary of the Curiosity rover's landing on Mars, Tuesday, August 6th, 2013 in Washington. The Mars Science Laboratory mission successfully placed the one-ton Curiosity rover on the surface of Mars on Aug. 6, 2012, about 1 mile from the center of its 12-mile-long target area. Within the first eight months of a planned 23-months primary mission, Curiosity met its major science objective of finding evidence of a past environment well-suited to support microbial life. Photo Credit: (NASA/Carla Cioffi)

  15. Curiosity Rover's First Anniversary

    NASA Image and Video Library

    2013-08-06

    NASA Administrator Charles Bolden speaks at a public event at NASA Headquarters observing the first anniversary of the Curiosity rover's landing on Mars, Tuesday, August 6th, 2013 in Washington. The Mars Science Laboratory mission successfully placed the one-ton Curiosity rover on the surface of Mars on Aug. 6, 2012, about 1 mile from the center of its 12-mile-long target area. Within the first eight months of a planned 23-months primary mission, Curiosity met its major science objective of finding evidence of a past environment well-suited to support microbial life. Photo Credit: (NASA/Carla Cioffi)

  16. Curiosity Rover's First Anniversary

    NASA Image and Video Library

    2013-08-06

    Jim Green, director, Planetary Division, NASA's Science Mission Directorate, answers a question at a public event at NASA Headquarters observing the first anniversary of the Curiosity rover's landing on Mars, Tuesday, August 6th, 2013 in Washington. The Mars Science Laboratory mission successfully placed the one-ton Curiosity rover on the surface of Mars on Aug. 6, 2012, about 1 mile from the center of its 12-mile-long target area. Within the first eight months of a planned 23-months primary mission, Curiosity met its major science objective of finding evidence of a past environment well-suited to support microbial life. Photo Credit: (NASA/Carla Cioffi)

  17. Curiosity Rover's First Anniversary

    NASA Image and Video Library

    2013-08-06

    Jim Green, director, Planetary Division, NASA's Science Mission Directorate, speaks at a public event at NASA Headquarters observing the first anniversary of the Curiosity rover's landing on Mars, Tuesday, August 6th, 2013 in Washington. The Mars Science Laboratory mission successfully placed the one-ton Curiosity rover on the surface of Mars on Aug. 6, 2012, about 1 mile from the center of its 12-mile-long target area. Within the first eight months of a planned 23-months primary mission, Curiosity met its major science objective of finding evidence of a past environment well-suited to support microbial life. Photo Credit: (NASA/Carla Cioffi)

  18. Curiosity Rover's First Anniversary

    NASA Image and Video Library

    2013-08-06

    Sam Scimemi, director, NASA's International Space Station Program, speaks at a public event at NASA Headquarters observing the first anniversary of the Curiosity rover's landing on Mars, Tuesday, August 6th, 2013 in Washington. The Mars Science Laboratory mission successfully placed the one-ton Curiosity rover on the surface of Mars on Aug. 6, 2012, about 1 mile from the center of its 12-mile-long target area. Within the first eight months of a planned 23-months primary mission, Curiosity met its major science objective of finding evidence of a past environment well-suited to support microbial life. Photo Credit: (NASA/Carla Cioffi)

  19. Curiosity Rover's First Anniversary

    NASA Image and Video Library

    2013-08-06

    Prasun Desai, acting director, Strategic Integration, NASA's Space Technology Mission Directorate, speaks at a public event at NASA Headquarters observing the first anniversary of the Curiosity rover's landing on Mars, Tuesday, August 6th, 2013 in Washington. The Mars Science Laboratory mission successfully placed the one-ton Curiosity rover on the surface of Mars on Aug. 6, 2012, about 1 mile from the center of its 12-mile-long target area. Within the first eight months of a planned 23-months primary mission, Curiosity met its major science objective of finding evidence of a past environment well-suited to support microbial life. Photo Credit: (NASA/Carla Cioffi)

  20. PREFACE: Part II of the Proceedings of the 25th International Conference on Low Temperature Physics

    NASA Astrophysics Data System (ADS)

    Kes, Peter; Jochemsen, Reyer

    2009-03-01

    This Issue of Journal of Physics: Conference Series forms Part II of the Proceedings of the 25th International Conference on Low Temperature Physics (LT25) held in Amsterdam, The Netherlands, 6-13 August 2008. Part II contains the papers of short oral and poster presentations. In addition, it provides general information about the LT25 conference, such as a Report from the Organizers, an Activity Report to the IUPAP of the C5 Chairs, an overview of Committees, Sponsors and Exhibitors, and some Conference Statistics. Part I of the Proceedings of LT25 is a special issue of Journal of Physics: Condensed Matter. It contains the majority of the special invited lectures, such as the London Prize Lectures, the IUPAP Young Scientist Award Lectures, the Plenary and Half Plenary and Public Lectures, and the Historical Lectures presented at the conference excursion to Leiden. The JPCM LT25 special issue is available for free for a period of one year from publication (Journal of Physics: Condensed Matter). To ensure the high publication standard mandated by Journal of Physics: Condensed Matter and Journal of Physics: Conference Series, every paper was reviewed by at least one referee before it was accepted for publication. The Editors are indebted to many colleagues for invaluable assistance in the preparation and with the reviewing of the 900 papers appearing in Parts I and II of these Proceedings. In particular, we like to thank Carlo Beenakker, Jeroen van den Brink, Hans Brom, Jos de Jongh, Horst Rogalla, and Fons de Waele. Guest Editors Peter Kes and Reijer Jochemsen Leiden University, The Netherlands Conference logo

  1. PREFACE: 25th International Congress on Condition Monitoring and Diagnostic Engineering (COMADEM 2012)

    NASA Astrophysics Data System (ADS)

    Ball, Andrew; Mishra, Rakesh; Gu, Fengshou; Rao, Raj B. K. N.

    2012-05-01

    The proactive multidisciplinary conceptual philosophy of Condition Monitoring and Diagnostic Engineering Management (COMADEM) was conceived and has been nurtured, developed and sustained since 1988. Since then, it is gratifying to note that the condition monitoring, diagnostic and prognostic community worldwide (representing industrialists, academics, research and development organizations, professional/private establishments and many hardware/software vending organizations) has warmly welcomed and supported this venture. As is evidenced, many have reaped (and are reaping) the benefits of COMADEM interdiscipline through continuous knowledge discovery, generation and dissemination. We are now proud to celebrate the 25th Annual Event (Silver Jubilee) in Huddersfield, the most beautiful part of the United Kingdom. The theme of this Congress is 'Sustained Prosperity through Proactive Monitoring, Diagnosis, Prognosis and Management'. This proceedings is enriched by contributions from many keynote experts representing many industry and academic establishments worldwide. Authors from more than 30 different countries have pooled their rich multidisciplinary up-to-date knowledge, in order to share their invaluable experience with the COMADEM community. In this proceedings, the readers will find more than 120 refereed papers encompassing a number of topical areas of interest relating to the theme of the congress. The proceedings of COMADEM 2012 will appear in the Open Access Journal of Physics: Conference Series (JPCS), which is part of the IOP Conference Series. All papers published in the IOP Conference Series are fully citable and upon publication will be free to download. We would like to express our deep gratitude to all the keynote speakers, authors, referees, exhibitors, Technical Co-Sponsoring Organizations, Gold Sponsors, IOP Publishers, COMADEM 2012 organizing committee members, delegates and many others on whom the success of this prestigious event depends

  2. 77 FR 76411 - Security Zone; 25th Annual North American International Auto Show, Detroit River, Detroit, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-28

    ... [Docket No. USCG-2012-1077] RIN 1625-AA87 Security Zone; 25th Annual North American International Auto... docket USCG-2012-1077. To view documents mentioned in this preamble as being available in the docket, go...; Department of Homeland Security Delegation No. 0170.1. 0 2. Add Sec. 165.T09-1077 to read as follows:...

  3. Rejuvenation by partial reprogramming of the epigenome.

    PubMed

    Mendelsohn, Andrew R; Larrick, James; Lei, Jennifer L

    2017-03-17

    Epigenetic variation with age is one of the most important hallmarks of aging. Resetting or repairing the epigenome of aging cells in intact animals may rejuvenate the cells and perhaps the entire organism. In fact, differentiated adult cells, which by definition have undergone some epigenetic changes, are capable of being rejuvenated and reprogrammed to create pluripotent stem cells and viable cloned animals. Apparently, such reprogramming is capable of completely resetting the epigenome. However, attempts to fully reprogram differentiated cells in adult animals have failed in part because reprogramming leads to formation of teratomas. A preliminary method to partially reprogram adult cells in mature Hutchinson-Guilford progeria (HGPS) mice by transient induction of the Yamanaka factors OSKM(Oct4/Sox2/Klf4/c-Myc) appears to ameliorate aging-like phenotypes in HGPS mice, and promote youthful regenerative capability in middle-aged wild type individuals exposed to beta cell and muscle cell specific toxins. However, whatever epigenetic repair is induced by transient reprogramming does not endure and may be due to the induction of key homeostatic regulators instead. Some of the effect of transient reprogramming may result from increased proliferation and enhanced function of adult stem cells. Partial reprogramming may point the way to new anti-aging and pro-regenerative therapeutics. Redifferentiation of cells into their pre-existing phenotype with simultaneous epigenomic rejuvenation is an interesting variation that also should be pursued. However, discovery of methods to more precisely repair the epigenome is the most likely avenue to the development of powerful new anti-aging agents.

  4. Noninvasive Facial Rejuvenation. Part 1: Patient-Directed

    PubMed Central

    Commander, Sarah Jane; Chang, Daniel; Fakhro, Abdulla; Nigro, Marjory G.; Lee, Edward I.

    2016-01-01

    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin and rejuvenate damaged skin. Physicians may recommend and often prescribe certain products, but the patients are in control of this type of facial rejuvenation. On the other hand, physician-directed facial rejuvenation entails modalities that require direct physician involvement, such as neuromodulators, filler injections, laser resurfacing, microdermabrasion, and chemical peels. With the successful integration of each of these modalities, a complete facial regimen can be established and patient satisfaction can be maximized. This article is the first in a three-part series describing noninvasive facial rejuvenation. The authors focus on patient-directed facial rejuvenation. It is important, however, to emphasize that even in a patient-directed modality, a physician's involvement through education and guidance is integral to its success. PMID:27478421

  5. Partial rejuvenation of a colloidal glass.

    PubMed

    Ozon, F; Narita, T; Knaebel, A; Debrégeas, G; Hébraud, P; Munch, J-P

    2003-09-01

    We study the effect of shear on the aging dynamics of a colloidal suspension of synthetic clay particles. We find that a shear of amplitude gamma reduces the relaxation time measured just after the cessation of shear by a factor exp(-gamma/gamma(c)), with gamma(c) approximately 5%, and is independent of the duration and the frequency of the shear. This simple law for the rejuvenation effect shows that the energy involved in colloidal rearrangements is proportional to the shear amplitude gamma rather than gamma(2), leading to an Eyring-like description of the dynamics of our system.

  6. Sustainable Rejuvenation of Electrochromic WO3 Films.

    PubMed

    Wen, Rui-Tao; Niklasson, Gunnar A; Granqvist, Claes G

    2015-12-30

    Devices relying on ion transport normally suffer from a decline of their long-term performance due to irreversible ion accumulation in the host material, and this effect may severely curtail the operational lifetime of the device. In this work, we demonstrate that degraded electrochromic WO3 films can sustainably regain their initial performance through galvanostatic detrapping of Li(+) ions. The rejuvenated films displayed degradation features similar to those of the as-prepared films, thus indicating that the detrapping process is effectively reversible so that long-term performance degradation can be successfully avoided. Detrapping did not occur in the absence of an electric current.

  7. 50th Anniversary Employee Picnic

    NASA Image and Video Library

    2011-10-08

    Nearly 500 Stennis Space Center employees and family members took part in the facility's 50th Anniversary Employee Picnic on Oct. 8. Participants enjoyed activities ranging from historical tours to sack races.

  8. 15th Anniversary of CMAS

    EPA Pesticide Factsheets

    The EPA recently celebrated the 15th anniversary of its partnership with the Community Modeling and Analysis System (CMAS) Center. CMAS provides training and support for the CMAQ community, and they host an annual workshop dedicated to exchanging ideas.

  9. Earthquake Forecasts for Gorkha Immediately Following the 25th April, M=7.8 Mainshock

    NASA Astrophysics Data System (ADS)

    Segkou, M.; Parsons, T.

    2015-12-01

    The M-7.8 Gorkha (Nepal) earthquake on the 25th April, 2015 has shaken the central Himalayan front and immediately raised concerns for the severity of future triggered earthquakes. Here, we implement standard and innovative forecast models to predict the spatio-temporal distribution of triggered events. Key challenges addressed are: 1) the limited information on early aftershocks, 2) the low-productivity aftershock sequence in the near-source area, 3) the off-fault (>250 km) triggered events exemplified by the M=5.4 Xegar event, 3 hrs after the mainshock. We apply short-term empirical/statistical ETAS and physical forecast models, the latter based on the combination of rate/state friction law and Coulomb stresses. Within the physics-based model implementation we seek to evaluate the uncertainty related with the rupture style of triggered events by considering: 1) the geometry of active structures, 2) optimally oriented for failure faults and 3) all-potential faults described by the total stress field. The latter is represented by the full stress tensor before and after the mainshock and our analysis suggests that the preseismic stress magnitudes are still sufficient to cause earthquakes even after modification by the mainshock. The above remark reveals that there are no "stress shadows" affecting the spatial distribution of near-field aftershocks. It is also noted that the method allows for an a-priori determination of the rupture plan of the M=7.3 event, within the limit of uncertainty (20˚). The results show that: (1) ETAS models underestimate the number of observed events, since they heavily base their good performance in small magnitude earthquakes, not available in the first few weeks after the mainshock, (2) far field triggered events are captured only by physics-based forecasts, and (3) the total stress method improves the predictability of larger magnitude events. We conclude that frontier regions benefit from the implementation of physics-based models

  10. Curiosity Rover's First Anniversary

    NASA Image and Video Library

    2013-08-06

    Jason Townsend, NASA's Deputy Social Media Manager, asks a question on behalf of a NASA Twitter follower at a public event at NASA Headquarters observing the first anniversary of the Curiosity rover's landing on Mars, Tuesday, August 6th, 2013 in Washington. The Mars Science Laboratory mission successfully placed the one-ton Curiosity rover on the surface of Mars on Aug. 6, 2012, about 1 mile from the center of its 12-mile-long target area. Within the first eight months of a planned 23-months primary mission, Curiosity met its major science objective of finding evidence of a past environment well-suited to support microbial life. Photo Credit: (NASA/Carla Cioffi)

  11. A medical geographical anniversary.

    PubMed

    Barrett, F A

    1993-09-01

    It is now 200 years since L. L. Finke wrote his treatise on a global medical geography, Versuch einer allgemeinen medicinisch-praktischen Geographie. It was both the most extensive book in substantive content, and the most detailed in conceptual discussion on medical geography written to that point. Although it is one of the foundation pieces of medical geography, modern day practitioners seldom refer to Finke's work. There are two main reasons for this: with the exception of two passages, the work has never been translated from the original German, and many contemporary medical geographers believe that the field only developed in the mid-twentieth century. This paper's purpose is to demonstrate that this last point is unfounded and that recognition of Finke's seminal contribution is long over-due. On the 200th anniversary of the publication of An Attempt at a General Medical-Practical Geography Finke's great achievement is honoured.

  12. Pad 39B Anniversary

    NASA Image and Video Library

    2017-05-17

    Launch Complex 39B current and past NASA and contractor workers gathered at pad B to mark the 50th anniversary of the launch complex at NASA's Kennedy Space Center in Florida. Upgrades to the surface of pad B, as well as the systems below and surrounding the pad will support the new processing and launch requirements for NASA's Space Launch System (SLS) and the Orion spacecraft for deep-space missions, including the journey to Mars. The modifications and improvements to processing and launch facilities will support Kennedy as a multi-user spaceport for government and commercial launches for years to come. The Ground Systems Development and Operations Program is overseeing upgrades and modifications to Pad 39B.

  13. Challenger Anniversary Resource Tape

    NASA Technical Reports Server (NTRS)

    1996-01-01

    This commemorative video marks the tenth anniversary, January 28, 1986, of the ninth Challenger flight and the seven astronauts onboard who died when the Challenger exploded 73 seconds into flight. The flight crew was comprised of Cmdr. Francis R. Scobee, Pilot Michael J. Smith, and Mission Specialists Judith A. Resnik, Ellison S. Onizuka, Ronald E. McNair, Gregory Jarvis (Hughes Aircraft representative), and S. Christie McAuliffe (teacher). The flight crew is shown performing preflight training, physiological tests, environmental tests, press conferences, prelaunch activities, and launch activities. The Challenger explosion is shown from both the launch site and from the control center. Various rescue operations, news coverage, and shots of the wreckage after salvage are also presented. President Ronald Reagan is shown giving a tribute at the memorial service for the flight crew. The video ends with a flyby salute and pictures of each of the members of the Challenger.

  14. Facial rejuvenation and light: our personal experience.

    PubMed

    Trelles, Mario A; Mordon, Serge; Calderhead, R Glen

    2007-06-01

    The treatment of ageing skin remains a very hot topic, and many systems have been reported as having varying degrees of success. Nonablative lasers were developed to avoid the problematic and uncomfortable sequelae following laser ablative resurfacing, and while there was no downtime, there was also poor patient satisfaction. The same was true of the intense pulsed light systems. The use of different modalities in various combinations was found to offer much better results, however, such as a 595-nm pulsed dye laser followed by a 1,450-nm diode laser, and so on, all used at subablative thresholds. The recent entry of blue and infrared tunable plasma light and light-emitting diodes into the skin rejuvenation arena has attracted a great deal of attention. The authors suggest that no single modality can accomplish all the complex events required for effective skin rejuvenation, suggest that combination phototherapy is the best approach combined with an adjunctive epidermal care regimen, and demonstrate their development of this methodology.

  15. Microstructural and Chemical Rejuvenation of a Ni-Based Superalloy

    NASA Astrophysics Data System (ADS)

    Yao, Zhiqi; Degnan, Craig C.; Jepson, Mark A. E.; Thomson, Rachel C.

    2016-12-01

    The microstructural evolution of the Ni-based superalloy CMSX-4 including the change in gamma prime morphology, size, and distribution after high-temperature degradation and subsequent rejuvenation heat treatments has been examined using field emission gun scanning electron microscopy and transmission electron microscopy. In this paper, it is shown that there are significant differences in the size of the `channels' between gamma prime particles, the degree of rafting, and the size of tertiary gamma prime particles in each of the different microstructural conditions studied. Chemical analysis has been carried out to compare rejuvenated and pre-service samples after the same subsequent degradation procedure. The results indicate that although the microstructures of pre-service and rejuvenated samples are similar, chemical differences are more pronounced in the rejuvenated samples, suggesting that chemical segregation from partitioning of the elements was not completely eliminated through the applied rejuvenation heat treatment. A number of modified rejuvenation heat treatment trials were carried out to reduce the chemical segregation prior to creep testing. The creep test results suggest that chemical segregation has an immeasurable influence on the short-term mechanical properties under the test conditions used here, indicating that further work is required to fully understand the suitability of specific rejuvenation heat treatments and their role in the extension of component life in power plant applications.

  16. The Neural Rejuvenation Hypothesis of Cocaine Addiction

    PubMed Central

    Dong, Yan; Nestler, Eric J.

    2014-01-01

    A leading hypothesis guiding current molecular and cellular research of drug addiction conceptualizes key aspects of addiction as a form of memory, in which common neuroplasticity mechanisms that mediate normal learning and memory processes are “hijacked” by exposure to drugs of abuse to produce pathologic addiction-related memories. Such addiction-related memories are particularly robust and long-lasting and once formed, less amenable to updating. Here, we propose the Neural Rejuvenation Hypothesis of Cocaine Addiction: that repeated exposure to drugs of abuse induces some plasticity mechanisms that are normally associated with brain development within the brain’s reward circuitry, which mediate the highly efficient and unusually stable memory abnormalities that characterize addiction. PMID:24958329

  17. TRMM 3-Year Anniversary

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Ever wonder about the rain? Beyond the practicality of needing an umbrella, climate researchers have wondered about the science of rainfall for a long time. But it's only in the past few years that they've begun to roll back some of its secrets. One of their tools for doing so is a powerful satellite called the Tropical Rainfall Measuring Mission, or TRMM. Now, after three years of continual operation, project scientists have released dramatic new maps of rainfall patterns gathered across a wide band of the Earth. And with measurements from one of the satellite's advanced sensors, meteorologists are now able to calibrate ground-based rain monitoring systems with greater precision than ever before. A complete accounting of the world's total rainfall has long been a major goal of climate researchers. Rain acts as the atmosphere's fundamental engine for heat exchange; every time a raindrop falls, the atmosphere gets churned up and latent heat flows back into the total climate system. Considering that rainfall is the primary driving force of heat in the atmosphere, and that two thirds of all rain falls in the tropics, these measurements are significant for our understanding of overall climate. The above image shows a one month average of rainfall measurements taken by the TRMM's unique precipitation radar during January of 1998. Areas of low rainfall are colored light blue, while regions with heavy rainfal are colored orange and red. TRMM began collecting data in December of 1997, and continues today. For more information about TRMM's 3-year anniversary, read Maps of Falling Water To learn more about the TRMM mission or order TRMM data, see the TRMM Home Page. Image courtesy TRMM Science team and the NASA GSFC Scientific Visualization Studio.

  18. Small RNAs of Sequoia sempervirens during rejuvenation and phase change.

    PubMed

    Chen, Y-T; Shen, C-H; Lin, W-D; Chu, H-A; Huang, B-L; Kuo, C-I; Yeh, K-W; Huang, L-C; Chang, I-F

    2013-01-01

    In this work, the population of small RNAs (sRNAs) was studied in the gymnosperm Sequoia sempervirens during phase changes, specifically in the juvenile, adult and rejuvenated plants obtained in vitro. The potential target genes of Sequoia sRNAs were predicted through bioinformatics. Rejuvenation is a pivotal process in woody plants that enables them to regain their growth potential, which results in the recovery of physiologic and molecular characteristics that were lost when the juveniles mature into adult plants. The results from the five repeated graftings of juvenile, adult and rejuvenated plants in vitro showed that sRNAs could be classified into structural RNAs (Group I), small interfering RNAs (Group II), annotated microRNAs (Group III, and unannotated sRNAs (Group IV). The results indicate that only 573 among 15,485,415 sRNAs (Groups III and IV) had significantly different expression patterns associated with rejuvenation and phase change. A total of 215 sRNAs exhibited up-regulated expression patterns in adult shoots, and 358 sRNAs were down-regulated. Expression profiling and prediction of possible target genes of these unique small RNAs indicate possible functions in the control of photosynthetic efficiency and rooting competence abundance during plant rejuvenation. Moreover, the increase in SsmiR156 and decrease in SsmiR172 during plant rejuvenation suggested that these two microRNAs extensively affect phase transition.

  19. Newly diagnosed hyperthyroidism in the 25th gestational week of pregnancy presenting with systolic arterial hypertension only.

    PubMed

    Zaveljcina, Janez; Legan, Mateja; Gaberšček, Simona

    2016-05-01

    We present a case of a 30-year-old woman diagnosed with arterial hypertension in the 25th week of pregnancy. Our search for secondary causes of arterial hypertension revealed hyperthyroid Hashimoto's thyroiditis (HT), which was treated with propilthiouracil. Three weeks after delivery, she was normotensive without medication. In the next four months, she developed hypothyroidism and treatment with L-thyroxine was started. In conclusion, in the second half of pregnancy, a hyperthyroid HT can occur - in spite of the well-known amelioration of autoimmune thyroid disorders in that period, and can be the only cause of arterial hypertension.

  20. 25th IAEA Fusion Energy Conference: summary of sessions EX/S, EX/W and ICC

    NASA Astrophysics Data System (ADS)

    Sen, A.

    2015-10-01

    This paper provides a summary overview, based on papers presented at the 25th IAEA Fusion Energy Conference (FEC), in the area of magnetic confinement experiments related to stability (EX/S), wave-plasma interactions, current drive, heating, energetic particles (EX/W) and innovative confinement concepts (ICCs). A selection of results that represent progress made since the last FEC in a few important thematic areas that are relevant for the successful and safe operation of future fusion devices like ITER, is highlighted.

  1. Shield Through Rejuvenated Stage Volcanism On Kauai and Niihau, Hawaii

    NASA Astrophysics Data System (ADS)

    Cousens, B.; Clague, D. A.

    2013-12-01

    Kauai and Niihau are the northwesternmost large islands in the Hawaiian chain and consist of shield, rare postshield, and abundant rejuvenated stage lavas. We present new geochronological, geochemical and isotopic data for all phases of volcanic activity on the adjacent islands. K-Ar ages show Niihau shield volcanism occurred from 6.3-4.4 Ma, and K-Ar and new Ar-Ar ages for postshield volcanism range from 5.4-4.7 Ma. Kauai shield volcanism (K-Ar) overlaps with shield volcanism on Niihau. A new Ar-Ar age for a Kauai postshield dike is 4.4 Ma, older than previously-dated postshield lavas (3.95-3.58 Ma). New Ar-Ar ages show that Kauai rejuvenated stage volcanism began prior to 3.42 Ma (Izuka & Sherrod, 2011), compared to ~2.3 Ma on Niihau. Tholeiitic shield lavas from Kauai vary only slightly in trace element chemistry but have variable isotopic compositions. Subtle trends in some trace element and isotopic ratios between Napali Member shield lavas from the east and west side of Kauai support the two-shield hypothesis of Holcomb et al. (1997). Shield lavas from Niihau are chemically similar to those on Kauai, although Niihau tholeiites extend to higher 143Nd/144Nd ratios. Onland and submarine postshield rocks from Niihau are slightly more alkaline and LREE-enriched compared to shield lavas, but postshield rocks from Kauai are more chemically evolved, more LREE-enriched, and have more depleted Sr and Nd isotopic signatures than Kauai tholeiites. Postshield rocks on Kauai overlap in apparent age with lavas that are chemically like later rejuvenated stage lavas, suggesting either interfingering of the chemically distinct lavas or problems with the K-Ar ages. Rejuvenated stage lavas from the two islands differ dramatically; Kauai lavas are alkaline, LREE-enriched, and have even more depleted Sr and Nd isotopic compositions than postshield lavas, whereas Niihau lavas are only mildly alkaline, have lower REE abundances than postshield basalts, but isotopically are like

  2. Stockpile Stewardship's 20th Anniversary

    SciTech Connect

    Hecker, Siegfried; Gottemoeller, Rose; Reis, Victor H.; McMillan, Charles; Rohlfing, Joan; Hurricane, Omar; Hagengruber, Roger; Taylor, John

    2015-10-22

    A short oral history of the NNSA's Stockpile Stewardship Program, produced in association with the 20th anniversary of the program. It features Siegfried Hecker, Rose Gottemoeller, Victor Reis, Charles McMillan, Joan Rohlfing, Omar Hurricane, Roger Hagengruber, and John Taylor.

  3. Stockpile Stewardship's 20th Anniversary

    ScienceCinema

    Hecker, Siegfried; Gottemoeller, Rose; Reis, Victor H.; McMillan, Charles; Rohlfing, Joan; Hurricane, Omar; Hagengruber, Roger; Taylor, John

    2016-07-12

    A short oral history of the NNSA's Stockpile Stewardship Program, produced in association with the 20th anniversary of the program. It features Siegfried Hecker, Rose Gottemoeller, Victor Reis, Charles McMillan, Joan Rohlfing, Omar Hurricane, Roger Hagengruber, and John Taylor.

  4. ENDOTHELIAL PROGENITOR CELLS: FROM SENESCENCE TO REJUVENATION

    PubMed Central

    Goligorsky, Michael S

    2014-01-01

    Discovered more than 15 years ago, endothelial progenitor cells attract both basic and translational researchers. It has become clear that they represent a heterogeneous population of endothelial colony forming cells, early or late outgrowth endothelial cells, or blood outgrowth endothelial cells, each characterized by differing proliferative and regenerative capacity. Scattered within the vascular wall, these cells participate in angiogenesis and vasculogenesis and support regeneration of epithelial cells. There is growing evidence that this cell population is impaired during the course of chronic cardiovascular and kidney disease when it undergoes premature senescence and loss of specialized functions. Senescence-associated secretory products released by such cells can affect the neighboring cells and further exacerbate their regenerative capacity. For those reasons adoptive transfer of endothelial progenitor cells is being used in more than 150 on-going clinical trials in diverse cardiovascular diseases. There is emergence of attempts to rejuvenate this cell population either ex vivo or in situ. The progress in this field is paramount to regenerate the injured kidney. PMID:25217265

  5. Endothelial progenitor cells: from senescence to rejuvenation.

    PubMed

    Goligorsky, Michael S

    2014-07-01

    Discovered more than 15 years ago, endothelial progenitor cells attract both basic and translational researchers. It has become clear that they represent a heterogeneous population of endothelial colony-forming cells, early or late outgrowth endothelial cells, or blood outgrowth endothelial cells, each characterized by differing proliferative and regenerative capacity. Scattered within the vascular wall, these cells participate in angiogenesis and vasculogenesis and support regeneration of epithelial cells. There is growing evidence that this cell population is impaired during the course of chronic cardiovascular and kidney disease when it undergoes premature senescence and loss of specialized functions. Senescence-associated secretory products released by such cells can affect the neighboring cells and further exacerbate their regenerative capacity. For these reasons, adoptive transfer of endothelial progenitor cells is being used in more than 150 ongoing clinical trials of diverse cardiovascular diseases. Attempts to rejuvenate this cell population either ex vivo or in situ are emerging. The progress in this field is paramount to regenerate the injured kidney. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Robotic-Assisted Upper Face Rejuvenation

    PubMed Central

    Rybakin, Arthur V.; Manturova, Natalia E.; Gladyshev, Dmitriy V.; Kamalov, David M.; Shcherbakov, Kirill G.; Staisupov, Valeriy J.; Kuzin, Danila A.

    2016-01-01

    Summary: Robotic-assisted technology has not been used in aesthetic surgery so far. The authors examined the feasibility and potential advantages of robotic-assisted technology in upper face rejuvenation surgery, as well as utility of the tools available in the market. Forehead lift was performed along with blepharoplasty in 4 patients. Robotic da Vinci Surgical System (Intuitive Surgical, Inc.) was used at the stage of dissection. The stereo endoscope 30 degrees, 12 mm and later 8.5 mm in diameter, and the set of tools, 8 mm and later 5 mm in diameter, were used. Overall results appeared to be essentially the same as after usual endoscope-assisted brow lift. The advantages of the robotic-assisted surgery were as follows: the best possible display, scalability of the picture; lack of tremor, scalability of the movements’ amplitude; high degree of freedom of movements exceeding human capabilities; quick and easy switch between the endoscope and any of the 3 manipulating arms; and enhanced comfort for a surgeon. The drawbacks noted were as follows: cost, steep learning curve, lack of tactile feedback, and absence of instruments specially adjusted for aesthetic surgery. The authors conclude that robots will enter the field of aesthetic plastic surgery in the same way as endoscopy, the proviso being to adjust tools to the specific needs.

  7. Surface rejuvenating effect of Achillea millefolium extract.

    PubMed

    Pain, S; Altobelli, C; Boher, A; Cittadini, L; Favre-Mercuret, M; Gaillard, C; Sohm, B; Vogelgesang, B; André-Frei, V

    2011-12-01

    Proopiomelanocortin is a precursor peptide that gives rise to several neuropeptides including adrenocorticotrophic hormone (ACTH) and β-endorphin. POMC-derived peptides have been shown to be synthesized in human epidermis where they modulate numerous skin functions. Because we previously observed that melanocortin receptor-2 and μ-opioid receptor 1, the respective receptors for ACTH and β-endorphin decreased with ageing in human epidermis, we have selected an active ingredient (INCI name: Achillea millefolium extract) able to upregulate receptor expressions. The aim of the present work was first to evaluate the effect of A. millefolium extract on the expression pattern of various epidermal differentiation markers ex vivo in normal human skin biopsies using quantitative image analysis and second to evaluate its capacity to rejuvenate the appearance of skin surface in vivo. Results show an improved expression profile of cytokeratin 10, transglutaminase-1 and filaggrin in cultured skin biopsies as well as an increased epidermal thickness. In vivo, a 2-month treatment with A. millefolium extract at 2% significantly improved the appearance of wrinkles and pores compared with placebo. Results were also directionally better than those of glycolic acid that was chosen as reference resurfacing molecule. © 2011 BASF Beauty Care Solutions France S.A.S. ICS © 2011 Society of Cosmetic Scientists and the Société Française de Cosmétologie.

  8. Rejuvenation in distinct cell populations - What does it mean?

    PubMed

    Hass, Ralf

    2009-10-01

    Rejuvenation represents a well organized and tightly regulated cellular process in vitro and in vivo, whereby senescent and/or certain differentiated cells revert specific properties acquired during previous steps of maturation to restore again a younger phenotype. Effects of the microenvironment and cellular mechanisms including asymmetric mitosis or retrodifferentiation can contribute to rejuvenation during a dynamic cellular development in contrast to terminally differentiated cells like unicellular organisms, which appear unable to retrodifferentiate and to rejuvenate. The process of rejuvenation is observed in distinct cell populations and includes a coordinated multistep network of transduction cascades with extracellular signaling and cell-to-cell communication to relay intracellular pathways. This provides a certain tissue homeostasis by a regenerative potential and renewal upon tissue-specific repair requirements in addition to residual stem cells, which can vary among different organs and species to extend their life span. However, dysfunctions within a rejuvenation program may also include the risk of neoplastic growth during such a retrograde development. In contrast to rejuvenation in certain cell types, a life span extension - also termed longevity - does not represent a retrograde development but an overall prolonged function of tissues, organs and/or whole organisms. Thus, rejuvenation of a distinct cell population could contribute to longevity of the corresponding organism but may not necessarily be required since longevity could also be achieved mechanistically by inhibition of the mTOR-mediated signaling pathway or by sufficient supply of anti-oxidative defence compounds, physiologically by nutrient restrictions, genetically by the induction of longevity genes or environmentally by the inhibition of aging.

  9. Preventing aging with stem cell rejuvenation: Feasible or infeasible?

    PubMed Central

    Honoki, Kanya

    2017-01-01

    Characterized by dysfunction of tissues, organs, organ systems and the whole organism, aging results from the reduced function of effective stem cell populations. Recent advances in aging research have demonstrated that old tissue stem cells can be rejuvenated for the purpose of maintaining the old-organ function by youthful re-calibration of the environment where stem cells reside. Biochemical cues regulating tissue stem cell function include molecular signaling pathways that interact between stem cells themselves and their niches. Historically, plasma fractions have been shown to contain factors capable of controlling age phenotypes; subsequently, signaling pathways involved in the aging process have been identified. Consequently, modulation of signaling pathways such as Notch/Delta, Wnt, transforming growth factor-β, JAK/STAT, mammalian target of rapamycin and p38 mitogen-activated protein kinase has demonstrated potential to rejuvenate stem cell function leading to organismic rejuvenation. Several synthetic agents and natural sources, such as phytochemicals and flavonoids, have been proposed to rejuvenate old stem cells by targeting these pathways. However, several concerns still remain to achieve effective organismic rejuvenation in clinical settings, such as possible carcinogenic actions; thus, further research is still required. PMID:28154735

  10. Three-Dimensional Rejuvenation of the Décolletage.

    PubMed

    Peterson, Jennifer D; Kilmer, Suzanne L

    2016-05-01

    Photodamaged skin of the chest is characterized by skin laxity, lines/wrinkles, hyperpigmentation, erythema, tactile roughness, atrophy, and telangiectasias. A MEDLINE search was performed on combination treatments in chest rejuvenation, and the results are summarized. Practical applications for these combinations of procedures are discussed. Reports of injectable poly-L-lactic acid (PLLA), hyaluronic acid (HA), and chemical peels, along with lasers and light therapies such as intense pulsed light (IPL), vascular lasers, photodynamic therapy (PDT), nonablative fractionated lasers (NAFLs), ablative fractionated lasers (AFLs), and microfocused ultrasound (MFU) have been reported for chest rejuvenation. Few articles were discovered pertaining to combination therapy. The authors review their approaches to combination therapy. Multiple options exist alone or in combination for minimally invasive rejuvenation of the skin of the chest including PLLA, HA, chemical peels, IPL, vascular lasers, PDT, NAFL, AFL, and MFU. Little was found in the literature pertaining to the safety and efficacy of combining such procedures and devices. The authors' experience in clinical practice is that combination, same day chest rejuvenation techniques can be performed safely. A combination approach often produces the most optimal outcome for the patient seeking chest rejuvenation.

  11. Perioral Rejuvenation With Ablative Erbium Resurfacing.

    PubMed

    Cohen, Joel L

    2015-11-01

    Since the introduction of the scanning full-field erbium laser, misconceptions regarding ablative erbium resurfacing have resulted in its being largely overshadowed by ablative fractional resurfacing. This case report illustrates the appropriateness of full-field erbium ablation for perioral resurfacing. A patient with profoundly severe perioral photodamage etched-in lines underwent full-field ablative perioral resurfacing with an erbium laser (Contour TRL, Sciton Inc., Palo Alto, CA) that allows separate control of ablation and coagulation. The pre-procedure consultations included evaluation of the severity of etched-in lines, and discussion of patient goals, expectations, and appropriate treatment options, as well as a review of patient photos and post-treatment care required. The author generally avoids full-field erbium ablation in patients with Fitzpatrick type IV and above. For each of 2 treatment sessions (separated by approximately 4 months), the patient received (12 cc plain 2% lidodaine) sulcus blocks before undergoing 4 passes with the erbium laser at 150 μ ablation, no coagulation, and then some very focal 30 μ ablation to areas of residual lines still visualized through the pinpoint bleeding. Similarly, full-field ablative resurfacing can be very reliable for significant wrinkles and creping in the lower eyelid skin--where often a single treatment of 80 μ ablation, 50 μ coagulation can lead to a nice improvement. Standardized digital imaging revealed significant improvement in deeply etched rhytides without significant adverse events. For appropriately selected patients requiring perioral (or periorbital) rejuvenation, full-field ablative erbium resurfacing is safe, efficacious and merits consideration.

  12. Controlled rejuvenation of amorphous metals with thermal processing.

    PubMed

    Wakeda, Masato; Saida, Junji; Li, Ju; Ogata, Shigenobu

    2015-05-26

    Rejuvenation is the configurational excitation of amorphous materials and is one of the more promising approaches for improving the deformability of amorphous metals that usually exhibit macroscopic brittle fracture modes. Here, we propose a method to control the level of rejuvenation through systematic thermal processing and clarify the crucial feasibility conditions by means of molecular dynamics simulations of annealing and quenching. We also experimentally demonstrate rejuvenation level control in Zr(55)Al(10)Ni(5)Cu(30) bulk metallic glass. Our local heat-treatment recipe (rising temperature above 1.1T(g), followed by a temperature quench rate exceeding the previous) opens avenue to modifying the glass properties after it has been cast and processed into near component shape, where a higher local cooling rate may be afforded by for example transient laser heating, adding spatial control and great flexibility to the processing.

  13. Resonance ultrasonic actuation and local structural rejuvenation in metallic glasses

    NASA Astrophysics Data System (ADS)

    Wang, D. P.; Yang, Y.; Niu, X. R.; Lu, J.; Yang, G. N.; Wang, W. H.; Liu, C. T.

    2017-06-01

    Using the method of contact resonance ultrasonic actuation (CRUA), we observed evidence of local structural rejuvenation at the surface of metallic glasses (MGs), arising from the increase of the vibration amplitude of the atoms after the resonance actuation. By adjusting the CRUA parameters, the size, pattern, and extent of the rejuvenated zones could be tailored. Nanoindentation tests revealed suppressed nucleation of shear bands after CRUA, originating from the homogenization of the local structure induced by the ultrasonic vibration. Compared with the structural homogenization from annealing, this method will not sacrifice the concentration of the free volume for the local structural constraint. These results are useful to understand the evolution of the microstructure and local structural rejuvenation of MGs, as well as the design of MGs with improved plasticity from the nanoscale to the microscale.

  14. Combination volume rejuvenation therapy of the face: fat, fillers, and Botox.

    PubMed

    Centeno, Robert F

    2006-01-01

    The author uses combination volume rejuvenation therapy (CVRT) in patients who desire facial rejuvenation with minimal downtime. He describes how the combined use of relatively large doses of multiple injectables-including fat, pharmaceutical soft tissue fillers, and Botox-permits simultaneous volume rejuvenation of most facial areas with or without excisional surgery.

  15. Systemic Problems: A perspective on stem cell aging and rejuvenation

    PubMed Central

    Conboy, Irina M.; Conboy, Michael J.; Rebo, Justin

    2015-01-01

    This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a “silver bullet” putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are “beyond parabiosis” for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging. PMID:26540176

  16. Systemic Problems: A perspective on stem cell aging and rejuvenation.

    PubMed

    Conboy, Irina M; Conboy, Michael J; Rebo, Justin

    2015-10-01

    This review provides balanced analysis of the advances in systemic regulation of young and old tissue stem cells and suggests strategies for accelerating development of therapies to broadly combat age-related tissue degenerative pathologies. Many highlighted recent reports on systemic tissue rejuvenation combine parabiosis with a "silver bullet" putatively responsible for the positive effects. Attempts to unify these papers reflect the excitement about this experimental approach and add value in reproducing previous work. At the same time, defined molecular approaches, which are "beyond parabiosis" for the rejuvenation of multiple old organs represent progress toward attenuating or even reversing human tissue aging.

  17. Happy Anniversary, VLT !

    NASA Astrophysics Data System (ADS)

    2004-04-01

    Five years at the service of Europe's astronomers VLT 5 Years One of the world's most advanced astronomical research facilities, the ESO Very Large Telescope (VLT) at the Paranal Observatory in the Chilean Atacama desert, celebrates an important anniversary today. On April 1, 1999, and following almost one year of extensive tests and careful trimming of its numerous high-tech parts, the first 8.2-m VLT Unit Telescope, Antu (UT1), was "handed over" to the astronomers. Since that date, science operations with this marvellous research tool have been continuous and intensive. Kueyen (UT2) started normal operations exactly one year later. Yepun (UT4) was offered to the scientific community in June 2001, while Melipal (UT3) followed in August 2001 [1]. Ever since, all four VLT Unit Telescopes, with an ever-growing suite of highly specialised, extremely powerful astronomical instruments have been in full operation, 365 nights a year. And this with unequalled success, as demonstrated by a long list of important scientific results, including a substantial number of exciting discoveries that are now opening new horizons in astrophysics. Moreover, thanks to heroic and persistent efforts by the dedicated teams of ESO scientists and engineers, the "downtime" due to technical problems has been very small, about 3 per cent, a number that is unequalled among the world's large telescope facilities. In addition, the weather conditions at the Paranal site in the dry Atacama desert in Northern Chile are truly excellent - this is indeed one of the best locations for astronomical observations on the surface of the Earth - and the corresponding "weather downtime" has only been around 10 per cent. This has resulted in an unbelievably low value of total downtime, most likely a new world record for ground-based 8-10 m class telescopes. VLT strong points The Very Large Telescope (VLT) is the world's largest and most advanced optical telescope. It comprises four 8.2-m reflecting Unit

  18. The Reno Report: Rejuvenating Public Confidence in Education.

    ERIC Educational Resources Information Center

    National Association of State Education Department Information Offices, Arlington, VA.

    The rejuvenation of sagging public confidence in education through better communication was the focus of the conference. Four specific objectives were outlined: (1) to improve the ability of educators to assess public attitudes toward and interest in public education; (2) to assess the impact of different media forms on public attitudes; (3) to…

  19. Academic Writing Retreat: A Time for Rejuvenated and Focused Writing

    ERIC Educational Resources Information Center

    Swaggerty, Elizabeth A.; Atkinson, Terry S.; Faulconer, Johna L.; Griffith, Robin R.

    2011-01-01

    The purpose of this article is to describe the impact of a three-day academic writing retreat on the writing lives of four female university faculty members. Goals of the retreat included rejuvenating their writing lives, focusing their research agendas, improving their writing, and engaging in concentrated blocks of writing and collaborative…

  20. Academic Writing Retreat: A Time for Rejuvenated and Focused Writing

    ERIC Educational Resources Information Center

    Swaggerty, Elizabeth A.; Atkinson, Terry S.; Faulconer, Johna L.; Griffith, Robin R.

    2011-01-01

    The purpose of this article is to describe the impact of a three-day academic writing retreat on the writing lives of four female university faculty members. Goals of the retreat included rejuvenating their writing lives, focusing their research agendas, improving their writing, and engaging in concentrated blocks of writing and collaborative…

  1. The Origin of Rejuvenated Magmatism on the Hawaiian Islands

    NASA Astrophysics Data System (ADS)

    Hofmann, A. W.; Farnetani, C. G.

    2013-12-01

    Rejuvenated volcanism on the Hawaiian islands has long been known for its enigmatic geochemical features, and both the geochemistry and geodynamics of "rejuvenation" are subject of debate. In particular, the consistently depleted nature of its isotopic compositions (unradiogenic Sr and radiogenic Nd-Hf isotopes relative to shield and post-shield lavas) is seemingly at odds with high concentrations of incompatible and volatile elements. Also, the isotopic distinctions between the shield basalts of the two parallel lines of Hawaiian volcanoes are lost during rejuvenated stages. Some earlier attempts to explain these phenomena invoked melting of local oceanic lithosphere heated by the Hawaiian plume, but the isotopic compositions, though depleted, are systematically different from Pacific upper mantle. More recent explanations invoked renewed melting of plume material that had previously produced shield-type tholeiitic magmas from its more fertile components. The renewed melting would involve the more refractory portions of the source rock that had escaped the earlier melting. But such models fail to explain why the volatile budget survived the earlier melting history. Another recent explanation invoked melting of the outer sheath of the plume consisting of mantle material entrained by the plume during its ascent. However, such entrained material lacks the excess temperature needed to undergo any melting at all. Our numerical simulations show that, 200 to 400 km downstream from the locus of shield volcanism, previously unmelted material rises slowly in the deep 'underbelly' of the plume, crosses the solidus at ~ 5GPa, and generates rejuvenated magmas. This material is ultimately derived from the upper portion of the thermal boundary layer from which the plume originates. It consists of 'ordinary', depleted mantle, it has not lost its volatiles, and it is hot enough to undergo low degrees of melting. This model can therefore resolve several unexplained features of

  2. Case study: An isolated severe storm with giant hail hit Slovenian capital city Ljubljana on May 25th 2009

    NASA Astrophysics Data System (ADS)

    Korosec, M.

    2009-09-01

    Introduction A quite unusual weather pattern for month of May with first and early season heat wave of year 2009 resulted in several days of active severe storms across central Europe and Alpine region. Synoptic situation On May 25th 2009, an omega block pattern with strong upper-level subtropical ridge extending over Mediterranean and Balkan Peninsula brought stable and warm conditions into Southern Europe. Elsewhere, two large-scale troughs were located over Western and Eastern Europe with very unstable environment. On the nose of the Mediterranean ridge a jet streak with moderate shear was placed while over the Southern Alpine region only weak shear was placed over Slovenia. Rich boundary layer moisture and steep lapse rates within an elevated mixed layer favored extreme amounts of CAPE. After strong diurnal heating and surface wind convergence along the local topography a few convective cells were triggered in the mountainous terrain while deep moist convection over the rest of Slovenia was trapped by the strong capping inversion. In late afternoon several cells from the mountainous terrain interfered with each other and explosive convective cell was initiated along their outflow boundaries. Increasing near surface southeasterly wind flow supported enhanced low-level shear and storm relative helicity which caused this cell to very rapidly grown into an organized supercell storm on the flat terrain in northern Slovenia. This supercell then started racing southeastwards towards Ljubljana, a capital city of Slovenia. It caused extensive hail damage with very large to giant hailstones up to 7cm in diameter falling over parts of Ljubljana and areas north and southeast of the city. Presentation of research This case study will go through a research of this very damaging hailstorm, throughout a detailed analysis of the synoptic situation including analysis of satellite, radar and surface observations. At first, forecasting models did not suggest organized convection

  3. Review of the 25th annual scientific meeting of the International Society for Biological Therapy of Cancer.

    PubMed

    Balwit, James M; Kalinski, Pawel; Sondak, Vernon K; Coulie, Pierre G; Jaffee, Elizabeth M; Gajewski, Thomas F; Marincola, Francesco M

    2011-05-12

    Led by key opinion leaders in the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided a scientific platform for ~500 attendees to exchange cutting-edge information on basic, clinical, and translational research in cancer immunology and immunotherapy. The meeting included keynote addresses on checkpoint blockade in cancer therapy and recent advances in therapeutic vaccination against cancer induced by Human Papilloma Virus 16. Participants from 29 countries interacted through oral presentations, panel discussions, and posters on topics that included dendritic cells and cancer, targeted therapeutics and immunotherapy, innate/adaptive immune interplay in cancer, clinical trial endpoints, vaccine combinations, countering negative regulation, immune cell trafficking to tumor microenvironment, and adoptive T cell transfer. In addition to the 50 oral presentations and >180 posters on these topics, a new SITC/iSBTc initiative to create evidence-based Cancer Immunotherapy Guidelines was announced. The SITC/iSBTc Biomarkers Taskforce announced the release of recommendations on immunotherapy biomarkers and a highly successful symposium on Immuno-Oncology Biomarkers that took place on the campus of the National Institutes of Health (NIH) immediately prior to the Annual Meeting. At the Annual Meeting, the NIH took the opportunity to publicly announce the award of the U01 grant that will fund the Cancer Immunotherapy Trials Network (CITN). In summary, the Annual Meeting gathered clinicians and scientists from academia, industry, and regulatory agencies from around the globe to interact and exchange important scientific advances related to tumor immunobiology and cancer immunotherapy.

  4. Review of the 25th annual scientific meeting of the International Society for Biological Therapy of Cancer

    PubMed Central

    2011-01-01

    Led by key opinion leaders in the field, the 25th Annual Meeting of the International Society for Biological Therapy of Cancer (iSBTc, recently renamed the Society for Immunotherapy of Cancer, SITC) provided a scientific platform for ~500 attendees to exchange cutting-edge information on basic, clinical, and translational research in cancer immunology and immunotherapy. The meeting included keynote addresses on checkpoint blockade in cancer therapy and recent advances in therapeutic vaccination against cancer induced by Human Papilloma Virus 16. Participants from 29 countries interacted through oral presentations, panel discussions, and posters on topics that included dendritic cells and cancer, targeted therapeutics and immunotherapy, innate/adaptive immune interplay in cancer, clinical trial endpoints, vaccine combinations, countering negative regulation, immune cell trafficking to tumor microenvironment, and adoptive T cell transfer. In addition to the 50 oral presentations and >180 posters on these topics, a new SITC/iSBTc initiative to create evidence-based Cancer Immunotherapy Guidelines was announced. The SITC/iSBTc Biomarkers Taskforce announced the release of recommendations on immunotherapy biomarkers and a highly successful symposium on Immuno-Oncology Biomarkers that took place on the campus of the National Institutes of Health (NIH) immediately prior to the Annual Meeting. At the Annual Meeting, the NIH took the opportunity to publicly announce the award of the U01 grant that will fund the Cancer Immunotherapy Trials Network (CITN). In summary, the Annual Meeting gathered clinicians and scientists from academia, industry, and regulatory agencies from around the globe to interact and exchange important scientific advances related to tumor immunobiology and cancer immunotherapy. PMID:21569425

  5. Visual Literacy in the Digital Age: Selected Readings from the Annual Conference of the International Visual Literacy Association (25th, Rochester, New York, October 13-17, 1993).

    ERIC Educational Resources Information Center

    Beauchamp, Darrel G.; And Others

    This document contains selected papers from the 25th annual conference of the International Visual Literacy Association (IVLA). Topics addressed in the papers include the following: visual literacy; graphic information in research and education; evaluation criteria for instructional media; understanding symbols in business presentations;…

  6. Teaching of Psychology: Ideas and Innovations. Proceedings of the Annual Conference (25th, Tarrytown, New York, March 25-26, 2011)

    ERIC Educational Resources Information Center

    Howell-Carter, Marya, Ed.; Gonder, Jennifer, Ed.

    2011-01-01

    Conference proceedings of the 25th Annual Conference on the Teaching of Psychology: Ideas and Innovations, sponsored by the Psychology Department of the State University of New York at Farmingdale. The conference theme for 2011 was: The Future of the Undergraduate Psychology Major: New Directions in an Evolving Educational Climate. The Conference…

  7. Canadian Library Association 25th Annual Conference, Hamilton, Ontario, 20-25 June 1970. Proceedings. Theme: Into the Seventies -Challenge of Change.

    ERIC Educational Resources Information Center

    Canadian Library Association, Ottawa (Ontario).

    The fifteen speeches presented at the 25th Annual Conference of the Canadian Library Association are: (1) Presidential Address, (2) Theme Day, (3) The Revolutionary 70's, Are We Ready, (4) The Prime Mover: The Role of the National Library, (5) What You Expect Out of Machines, (6) Twenty-Seven Million People: Four Million Square Miles: Where Shall…

  8. Deeply Rooted, Branching Out, 1972-1997. Annual AEE International Conference Proceedings (25th, Asheville, North Carolina, November 23-26, 1997).

    ERIC Educational Resources Information Center

    Harwell, Rick, Ed.; Comstedt, Timothea, Ed.; Roberts, Nina, Ed.

    This proceedings contains 36 papers presented at the 25th Annual Conference of the Association for Experiential Education. Papers are: "The Woods and the Trees: Interpreting Experiential Education for Schools and a Greater Audience" (Joanna Allen, John Hutchinson); "Adventure Programming & Prevention of Adolescent Problem…

  9. Canadian Library Association 25th Annual Conference, Hamilton, Ontario, 20-25 June 1970. Proceedings. Theme: Into the Seventies -Challenge of Change.

    ERIC Educational Resources Information Center

    Canadian Library Association, Ottawa (Ontario).

    The fifteen speeches presented at the 25th Annual Conference of the Canadian Library Association are: (1) Presidential Address, (2) Theme Day, (3) The Revolutionary 70's, Are We Ready, (4) The Prime Mover: The Role of the National Library, (5) What You Expect Out of Machines, (6) Twenty-Seven Million People: Four Million Square Miles: Where Shall…

  10. Proceedings of the Conference of the International Group for the Psychology of Mathematics Education (25th, Utrecht, The Netherlands, July 12-17, 2001). Volumes 1-4.

    ERIC Educational Resources Information Center

    van den Heuvel-Panhuizen, Marja, Ed.

    This document contains the proceedings of the 25th annual Conference of the International Group for the Psychology of Mathematics Education (PME). It features plenary lectures, research forums, discussion groups, working sessions, short oral communications, and poster presentations. Papers in Volume 1 include: (1) "The P in PME: Progress and…

  11. Skin Rejuvenation with Non-Invasive Pulsed Electric Fields

    NASA Astrophysics Data System (ADS)

    Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P.; Albadawi, Hassan; Felix Broelsch, G.; Watkins, Michael T.; Georgakoudi, Irene; Papisov, Mikhail; Mihm, Martin C., Jr.; Austen, William G., Jr.; Yarmush, Martin L.

    2015-05-01

    Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases.

  12. Skin Rejuvenation with Non-Invasive Pulsed Electric Fields

    PubMed Central

    Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P.; Albadawi, Hassan; Felix Broelsch, G.; Watkins, Michael T.; Georgakoudi, Irene; Papisov, Mikhail; Mihm Jr., Martin C.; Austen Jr., William G.; Yarmush, Martin L.

    2015-01-01

    Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases. PMID:25965851

  13. Skin rejuvenation with non-invasive pulsed electric fields.

    PubMed

    Golberg, Alexander; Khan, Saiqa; Belov, Vasily; Quinn, Kyle P; Albadawi, Hassan; Felix Broelsch, G; Watkins, Michael T; Georgakoudi, Irene; Papisov, Mikhail; Mihm, Martin C; Austen, William G; Yarmush, Martin L

    2015-05-12

    Degenerative skin diseases affect one third of individuals over the age of sixty. Current therapies use various physical and chemical methods to rejuvenate skin; but since the therapies affect many tissue components including cells and extracellular matrix, they may also induce significant side effects, such as scarring. Here we report on a new, non-invasive, non-thermal technique to rejuvenate skin with pulsed electric fields. The fields destroy cells while simultaneously completely preserving the extracellular matrix architecture and releasing multiple growth factors locally that induce new cells and tissue growth. We have identified the specific pulsed electric field parameters in rats that lead to prominent proliferation of the epidermis, formation of microvasculature, and secretion of new collagen at treated areas without scarring. Our results suggest that pulsed electric fields can improve skin function and thus can potentially serve as a novel non-invasive skin therapy for multiple degenerative skin diseases.

  14. Apollo 40th Anniversary Press Conference

    NASA Image and Video Library

    2009-07-19

    Eugene Cernan (Apollo 17) speaks during the 40th anniversary of the Apollo 11 mission and the walk on the moon press conference, Monday, July 20, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

  15. [50th anniversary of cisplatin].

    PubMed

    Rancoule, Chloé; Guy, Jean-Baptiste; Vallard, Alexis; Ben Mrad, Majed; Rehailia, Amel; Magné, Nicolas

    2017-02-01

    We have just celebrated the 50th anniversary of cisplatin cytotoxic potential discovery. It is time to take stock… and it seems mainly positive. This drug, that revolutionized the treatment of many cancer types, continues to be the most widely prescribed chemotherapy. Despite significant toxicities, resistance mechanisms associated with treatment failures, and unresolved questions about its mechanism of action, the use of this cytotoxic agent remains unwavering. The interest concerning this "old" invincible drug has not yet abated. Indeed many research axes are in the news. New platinum salts agents are tested, new cisplatin formulations are developed to target tumor cells more efficiently, and new combinations are established to increase the cytotoxic potency of cisplatin or overcome the resistance mechanisms.

  16. Pandemic Influenza's 500th Anniversary

    PubMed Central

    Morens, David M.; Taubenberger, Jeffery K.; Folkers, Gregory K.; Fauci, Anthony S.

    2010-01-01

    It is impossible to know with certainty the first time that an influenza virus infected humans or when the first influenza pandemic occurred. However, many historians agree that the year 1510 a.d.—500 years ago—marks the first recognition of pandemic influenza. On this significant anniversary it is timely to ask: what were the circumstances surrounding the emergence of the 1510 pandemic, and what have we learned about this important disease over the subsequent five centuries?We conclude that in recent decades significant progress has been made in diagnosis, prevention, control, and treatment of influenza. It seems likely that, in the foreseeable future, we may be able to greatly reduce the burden of influenza pandemics with improved vaccines and other scientific and public health approaches. PMID:21067353

  17. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease

    PubMed Central

    Horowitz, Alana M.; Villeda, Saul A.

    2017-01-01

    Neurodegenerative diseases are a devastating group of conditions that cause progressive loss of neuronal integrity, affecting cognitive and motor functioning in an ever-increasing number of older individuals. Attempts to slow neurodegenerative disease advancement have met with little success in the clinic; however, a new therapeutic approach may stem from classic interventions, such as caloric restriction, exercise, and parabiosis. For decades, researchers have reported that these systemic-level manipulations can promote major functional changes that extend organismal lifespan and healthspan. Only recently, however, have the functional effects of these interventions on the brain begun to be appreciated at a molecular and cellular level. The potential to counteract the effects of aging in the brain, in effect rejuvenating the aged brain, could offer broad therapeutic potential to combat dementia-related neurodegenerative disease in the elderly. In particular, results from heterochronic parabiosis and young plasma administration studies indicate that pro-aging and rejuvenating factors exist in the circulation that can independently promote or reverse age-related phenotypes. The recent demonstration that human umbilical cord blood similarly functions to rejuvenate the aged brain further advances this work to clinical translation. In this review, we focus on these blood-based rejuvenation strategies and their capacity to delay age-related molecular and functional decline in the aging brain. We discuss new findings that extend the beneficial effects of young blood to neurodegenerative disease models. Lastly, we explore the translational potential of blood-based interventions, highlighting current clinical trials aimed at addressing therapeutic applications for the treatment of dementia-related neurodegenerative disease in humans. PMID:28815019

  18. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease.

    PubMed

    Horowitz, Alana M; Villeda, Saul A

    2017-01-01

    Neurodegenerative diseases are a devastating group of conditions that cause progressive loss of neuronal integrity, affecting cognitive and motor functioning in an ever-increasing number of older individuals. Attempts to slow neurodegenerative disease advancement have met with little success in the clinic; however, a new therapeutic approach may stem from classic interventions, such as caloric restriction, exercise, and parabiosis. For decades, researchers have reported that these systemic-level manipulations can promote major functional changes that extend organismal lifespan and healthspan. Only recently, however, have the functional effects of these interventions on the brain begun to be appreciated at a molecular and cellular level. The potential to counteract the effects of aging in the brain, in effect rejuvenating the aged brain, could offer broad therapeutic potential to combat dementia-related neurodegenerative disease in the elderly. In particular, results from heterochronic parabiosis and young plasma administration studies indicate that pro-aging and rejuvenating factors exist in the circulation that can independently promote or reverse age-related phenotypes. The recent demonstration that human umbilical cord blood similarly functions to rejuvenate the aged brain further advances this work to clinical translation. In this review, we focus on these blood-based rejuvenation strategies and their capacity to delay age-related molecular and functional decline in the aging brain. We discuss new findings that extend the beneficial effects of young blood to neurodegenerative disease models. Lastly, we explore the translational potential of blood-based interventions, highlighting current clinical trials aimed at addressing therapeutic applications for the treatment of dementia-related neurodegenerative disease in humans.

  19. Thermal rejuvenation of continental lithosphere in the Michigan Basin Area

    SciTech Connect

    Ahern, J.L.; Dikeou, P.J.

    1985-01-01

    Using depths to formation tops from almost 500 wells, the authors have determined changes in shape of the Michigan Basin during the Phanerozoic. Flexural rigidity of the lithosphere was then estimated for several time intervals by assuming that changes in shape were caused by deflection of an elastic plate subjected to a disk load. It is found that the flexural rigidity generally increased over time, from less than 10/sup 29/ dyne-cm early in the basin's history, to more than 10/sup 30/ dyne-cm late in the basin's development. They attribute this increase in rigidity to cooling and thickening of the elastic portion of the lithosphere as the basin was subsiding. Low flexural rigidity early in the basin's history indicates that the lithosphere was probably rejuvenated prior to basin subsidence. The rejuvenation process is investigated using a finite-difference thermal model in which a 142-km plate is temporarily heated from below. Taking the depth to the 450/sup 0/C isotherm to be the effective elastic thickness of the lithosphere, rigidity predicted by the thermal model is consistent with the observed increase in rigidity over time. They conclude that the lithosphere in this area was rejuvenated approximately 500 million years ago. As the lithosphere cooled, it thickened; it also contracted and subsided. Observed rapid subsidence between about 500 and 450 million years ago cannot be explained by thermal contraction; in fact, it occurs when the thermal model predicts heating and uplift. This subsidence episode may have been the result of densification processes accompanying rejuvenation.

  20. Subbrow blepharoplasty for upper eyelid rejuvenation in Asians.

    PubMed

    Lee, Daniel; Law, Victor

    2009-01-01

    Classical blepharoplasty removes supratarsal upper eyelid skin rather than subbrow skin. It does not adequately address the redundant skin of lateral hooding. Asians tend to have higher eyebrows than whites. For Asian women who have tattooed eyebrows with redundant upper lateral eyelid skin and who request a rejuvenating upper eyelid procedure, subbrow blepharoplasty (SBB) is an additional option to consider. This study evaluated the role of a less commonly employed blepharoplasty technique in rejuvenating the upper eyelid in carefully selected patients. The value of this technique was judged by patient-reported ratings. This was a prospective study. Patients presenting to our clinic between January 1997 and September 2008 for the excision of redundant upper eyelid skin were interviewed and examined for suitability for SBB. In this 11-year period, 804 patients underwent upper blepharoplasty. Of these patients, 101 (12.6%) were deemed suitable and were selected for SBB. Criteria for inclusion into the study were those who had dermatochalasis of the upper eyelids with lateral hooding. The aesthetic improvements were judged by the patients' subjective impressions (either satisfactory or unsatisfactory). All ratings were collected at four weeks postsurgery. Ninety-two patients (91.1%) rated their results as satisfactory, and nine patients (8.9%) rated their results as unsatisfactory. SBB is a useful operation to rejuvenate the upper eyelids in selected patients while maintaining harmony with their ethnic facial features. This refinement overcomes some of the shortcomings of other upper blepharoplasty methods employed for the same purpose.

  1. Months between rejuvenation and volcanic eruption at Yellowstone caldera, Wyoming

    USGS Publications Warehouse

    Till, Christy B.; Vazquez, Jorge A.; Boyce, Jeremy W

    2015-01-01

    Rejuvenation of previously intruded silicic magma is an important process leading to effusive rhyolite, which is the most common product of volcanism at calderas with protracted histories of eruption and unrest such as Yellowstone, Long Valley, and Valles, USA. Although orders of magnitude smaller in volume than rare caldera-forming super-eruptions, these relatively frequent effusions of rhyolite are comparable to the largest eruptions of the 20th century and pose a considerable volcanic hazard. However, the physical pathway from rejuvenation to eruption of silicic magma is unclear particularly because the time between reheating of a subvolcanic intrusion and eruption is poorly quantified. This study uses geospeedometry of trace element profiles with nanometer resolution in sanidine crystals to reveal that Yellowstone’s most recent volcanic cycle began when remobilization of a near- or sub-solidus silicic magma occurred less than 10 months prior to eruption, following a 220,000 year period of volcanic repose. Our results reveal a geologically rapid timescale for rejuvenation and effusion of ~3 km3 of high-silica rhyolite lava even after protracted cooling of the subvolcanic system, which is consistent with recent physical modeling that predict a timescale of several years or less. Future renewal of rhyolitic volcanism at Yellowstone is likely to require an energetic intrusion of mafic or silicic magma into the shallow subvolcanic reservoir and could rapidly generate an eruptible rhyolite on timescales similar to those documented here.

  2. The October 25th 2015 super-cell storm over central Israel: numerical simulations with the WRF model

    NASA Astrophysics Data System (ADS)

    Lynn, Barry; Yair, Yoav

    2017-04-01

    We present high-resolution WRF simulations with lightning assimilation (Fierro et al., 2012; Lynn et al., 2015) coupled with the Dynamic Lightning Scheme (Lynn et al., 2012) of the October 25th 2015 super-cell event in the eastern Mediterranean. That storm developed within the northern tip of a Red-Sea trough off the Egyptian coastline near Alexandria, with deep convective cells rapidly growing over the sea, exhibiting cloud top temperatures colder than -70°C ( 18 km) and radar reflectivity cores > 65 dBz at 10 km. As the cells crossed the Israeli coast-line north of Tel-Aviv, they exhibited intensive lightning activity, severe hail, downbursts, and intense rain. The lightning detection system of the Israeli Electrical Corporation registered a total of over 17,000 CGs, and for 20 minutes at the peak of the event recorded CG flash-rates greater than 430 strokes per minute (if including IC strokes, it was likely higher). The results of the simulations properly reconstruct the rapid growth of vertically extensive high-reflectivity cores, with significant amounts of graupel, ice and supercooled water within the charging zone below -20C. This guaranteed the effectiveness of non-inductive charge separation processes leading to the exceptional flash rates that were observed. Fierro, A. O, E. R. Mansell, C. L. Ziegler, and D. R. MacGorman, 2012: Application of a Lightning Data Assimilation Technique in the WRF-ARW Model at Cloud-Resolving Scales for the Tornado Outbreak of 24 May 2011. Mon. Wea. Rev., 140, 2609-2627. Lynn, B. H., G. Kelman, and G. Ellrod, 2015: An Evaluation of the Efficacy of Using Observed Lightning to Improve Convective Lightning Forecasts. Wea. Forecasting, 30, 405-423. Lynn, B. H., Y. Yair, C. Price, G. Kelman, and A. J. Clark, 2012: Predicting cloud-to-ground and intracloud lightning in weather forecast models.Wea. Forecasting, 27, 1470-1488, doi:10.1175/WAF-D-11-00144.1.

  3. Analysis of the Relationships between Waste Cooking Oil Qualities and Rejuvenated Asphalt Properties.

    PubMed

    Zhang, Dong; Chen, Meizhu; Wu, Shaopeng; Liu, Jingxiang; Amirkhanian, Serji

    2017-05-06

    Waste cooking oil (WCO), in many cases, can rejuvenate aged asphalt and restore its properties. However, the influence of WCO qualities on rejuvenation behaviors of aged asphalt has not been investigated in detail. The objective of this paper was to evaluate the effects of WCO viscosity and acid value on the basic, rheological, and chemical properties of a typical rejuvenated asphalt. Penetration, ring and ball (R and B) softening point, and ductility were tested to evaluate the influence of WCO qualities on basic properties of rejuvenated asphalts. Then, the rheological properties of rejuvenated asphalt were characterized based on rotational viscometer (RV), dynamic shear rheometer (DSR), and bending beam rheometer (BBR) test results. Further, SARA (saturates, aromatics, resins, and asphaltenes) fraction analysis and Fourier transform infrared spectroscopy (FTIR) tests were performed to investigate the effects of WCO qualities on asphalt chemical composition. Finally, grey correlation coefficients were calculated and the relationships between WCO qualities and rejuvenated asphalt properties were quantitatively evaluated. The experimental results indicated that WCO qualities influence the rejuvenation behaviors of aged asphalt significantly, and the WCO with higher qualities (low acid value and viscosity, as defined in this research) tends to achieve better rejuvenation effects. Based on the results of grey correlation analyses, the acid value is, relatively, a better indicator than viscosity in predicting the rejuvenation efficiency of WCO. The rejuvenation thresholds of WCO are varied with the categories of properties of rejuvenated asphalts, and WCO with an acid value of 0.4-0.7 mg KOH/g, or a viscosity of 140-540 mm²/s, can meet all of the performance requirements for asphalt rejuvenation used in this research.

  4. Analysis of the Relationships between Waste Cooking Oil Qualities and Rejuvenated Asphalt Properties

    PubMed Central

    Zhang, Dong; Chen, Meizhu; Wu, Shaopeng; Liu, Jingxiang; Amirkhanian, Serji

    2017-01-01

    Waste cooking oil (WCO), in many cases, can rejuvenate aged asphalt and restore its properties. However, the influence of WCO qualities on rejuvenation behaviors of aged asphalt has not been investigated in detail. The objective of this paper was to evaluate the effects of WCO viscosity and acid value on the basic, rheological, and chemical properties of a typical rejuvenated asphalt. Penetration, ring and ball (R and B) softening point, and ductility were tested to evaluate the influence of WCO qualities on basic properties of rejuvenated asphalts. Then, the rheological properties of rejuvenated asphalt were characterized based on rotational viscometer (RV), dynamic shear rheometer (DSR), and bending beam rheometer (BBR) test results. Further, SARA (saturates, aromatics, resins, and asphaltenes) fraction analysis and Fourier transform infrared spectroscopy (FTIR) tests were performed to investigate the effects of WCO qualities on asphalt chemical composition. Finally, grey correlation coefficients were calculated and the relationships between WCO qualities and rejuvenated asphalt properties were quantitatively evaluated. The experimental results indicated that WCO qualities influence the rejuvenation behaviors of aged asphalt significantly, and the WCO with higher qualities (low acid value and viscosity, as defined in this research) tends to achieve better rejuvenation effects. Based on the results of grey correlation analyses, the acid value is, relatively, a better indicator than viscosity in predicting the rejuvenation efficiency of WCO. The rejuvenation thresholds of WCO are varied with the categories of properties of rejuvenated asphalts, and WCO with an acid value of 0.4–0.7 mg KOH/g, or a viscosity of 140–540 mm2/s, can meet all of the performance requirements for asphalt rejuvenation used in this research. PMID:28772862

  5. MedlinePlus Marks its 15th Anniversary

    MedlinePlus

    ... page: https://medlineplus.gov/anniversary.html MedlinePlus Marks its 15 th Anniversary To use the sharing features ... people across the country and around the world. It now includes: Over 950 pages providing links to ...

  6. Neoplasia: An Anniversary of Progress

    PubMed Central

    Rehemtulla, Alnawaz

    2007-01-01

    This issue marks the 10th year anniversary of Neoplasia where we have seen exciting growth on the impact that Neoplasia has had on cancer research worldwide. Neoplasia was founded in 1999 at which time manuscripts were accepted through e-mail. In 2000, Neoplasia became the first journal to offer web-based online manuscript submission and peer-review using a custom-designed application JournalSoft. Now, the use of web-based manuscript processing has become an industry standard as it provides authors with a rapid and useful dialog exchange for improving the quality of the science and the overall speed of the review process. Moreover, during the past 10 years, the Internet has experienced a massive growth of a complex global grid of now over an estimated 1.2 billion Internet users which have resulted in a major shift in the medium of scientific communication for scholarly publishing. Neoplasia continues to evolve with the technology and has implemented a rapid time-to-publication schedule to continue dissemination of published cancer research findings quickly to the scientific community.

  7. 46 CFR 188.10-1 - Anniversary date.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Anniversary date. 188.10-1 Section 188.10-1 Shipping... PROVISIONS Definition of Terms Used in This Subchapter § 188.10-1 Anniversary date. The term anniversary date means the day and the month of each year, which corresponds to the date of expiration of the...

  8. Aging, Rejuvenation, and Epigenetic Reprogramming: Resetting the Aging Clock

    PubMed Central

    Rando, Thomas A.; Chang, Howard Y.

    2012-01-01

    The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges. PMID:22265401

  9. Hand Rejuvenation: A Comprehensive Review of Fat Grafting.

    PubMed

    Hoang, Don; Orgel, Matthew I; Kulber, David A

    2016-05-01

    Dermal atrophy, bulging reticular veins, and prominent bones and tendons are characteristic of the aging hand. Demand for cosmetic procedures to restore a youthful appearance to the dorsum of the hand has risen in recent years. A review of the literature reveals that of the many options for hand restoration, autologous fat grafting stands out as the most promising choice compared with many available alternative options such as microdermabrasion, peeling agents, and dermal fillers. This article details the surgical technique and relevant anatomy necessary for successful hand rejuvenation. Future advancements may rely on further study into adipose-derived stem cells.

  10. Aging and rejuvenation of a TMAE + methane multiwire photon detector

    SciTech Connect

    Korpar, S. |; Krizan, P.; Stanovnik, A. |; Staric, M.; Skrk, D.

    1999-06-01

    A UV sensitive multiwire photon detector has been tested as a possible candidate for the HERA-B RICH detector. The main obstacle to using such a TMAE+Methane filled gas detector in a high rate experiment appears to be rapid aging in the form of prohibitive loss of chamber gas gain. A special circuit has been designed for heating the anode wires in-situ with elevated currents, thus evaporating the polymer deposits. Heating almost completely recovers the initial gain, but this rejuvenation is unfortunately of short duration. Nevertheless, the cells exposed to periodic heat treatments have an average gain considerably higher than the non-heated cells.

  11. Estimating Periodic Software Rejuvenation Schedules under Discrete-Time Operation Circumstance

    NASA Astrophysics Data System (ADS)

    Iwamoto, Kazuki; Dohi, Tadashi; Kaio, Naoto

    Software rejuvenation is a preventive and proactive solution that is particularly useful for counteracting the phenomenon of software aging. In this article, we consider periodic software rejuvenation models based on the expected cost per unit time in the steady state under discrete-time operation circumstance. By applying the discrete renewal reward processes, we describe the stochastic behavior of a telecommunication billing application with a degradation mode, and determine the optimal periodic software rejuvenation schedule minimizing the expected cost. Similar to the earlier work by the same authors, we develop a statistically non-parametric algorithm to estimate the optimal software rejuvenation schedule, by applying the discrete total time on test concept. Numerical examples are presented to estimate the optimal software rejuvenation schedules from the simulation data. We discuss the asymptotic behavior of estimators developed in this paper.

  12. [Two anniversaries in Czech forensic medicine].

    PubMed

    Nečas, P; Hejna, P

    2012-10-01

    The authors commemorate the 100th anniversary of the publication of Slavíks textbook Forensic Pathology for Medical and Legal Students and the 125th anniversary of the 1st Czech forensic autopsy. They introduce professor V. Slavík and describe his personal qualities and expertise. The content of the textbook is described. The topicality of Slavíks explanations and the tradition of Czech forensic pathology are discussed. Key words: forensic pathology - history of Czech forensic pathology - textbooks of forensic pathology.

  13. 1965-1990: 25th anniversary of nurse practitioners. A classic manuscript reprinted in celebration of 25 years of progress. The Burlington randomized trial of the nurse practitioner. 1971-2.

    PubMed

    Spitzer, W O; Sackett, D L; Sibley, J C; Roberts, R S; Gent, M; Kergin, D J; Hackett, B C; Olynich, A; Hay, W I; Lefroy, G

    1990-01-01

    From July 1971, to July 1972, in a large suburban Ontario practice of two family physicians, a randomized controlled trial was conducted to assess the effects of substituting nurse practitioners for physicians in primary-care practice. Before and after the trial, the health status of patients who received conventional care from family physicians was compared with the status of those who received care mainly from nurse practitioners. Both groups of patients had a similar mortality experience, and no differences were found in in physical functional capacity, social function or emotional function. The quality of care rendered to the two groups seemed similar, as assessed by a quantitative "indicator-condition" approach. Satisfaction was high among both patients and professional personnel. Although cost effective from society's point of view, the new method of primary care was not financially profitable to doctors because of current restrictions on reimbursement for the nurse-practitioner services.

  14. A resolution acknowledging the 25th anniversary of the nomination of Representative Geraldine A. Ferraro as the first woman selected by a major political party to run for the Office of the Vice President.

    THOMAS, 111th Congress

    Sen. Gillibrand, Kirsten E. [D-NY

    2009-07-16

    07/16/2009 Referred to the Committee on the Judiciary. (text of measure as introduced: CR S7653) (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  15. Toothpaste microstructure and rheological behaviors including aging and partial rejuvenation

    NASA Astrophysics Data System (ADS)

    Liu, Zhiwei; Liu, Lei; Zhou, Huan; Wang, Jiali; Deng, Linhong

    2015-08-01

    Toothpastes are mainly composed of a dense suspension of abrasive substances, flavors, and therapeutic ingredients in a background liquid of humectants and water, and usually exhibit complex rheological behaviors. However, the relationship between the rheology and microstructure of toothpaste remains to be studied. In this paper, three commonly used toothpastes, namely Colgate, Darlie and Yunnan Baiyao (Ynby), were qualitatively and quantitatively studied as soft glassy materials. We found that although the three toothpastes generally behaved in similar fashion in terms of rheology, each particular one was distinct from others in terms of the quantitative magnitude of the rheologcial properties including thixotropy, creep and relaxation, yield stress, and power-law dependence of modulus on frequency. In addition, the history-dependent effects were interpreted in terms of aging and rejuvenation phenomena, analogous to those existing in glassy systems, and Ynby seemed to result in greater extent of aging and rejuvenation as compared to the other two. All these differences in toothpaste rheology may well be attributed to the different microscopic network microstructures as observed in this study. Therefore, this study provides first evidence of microstructurebased rheological behaviors of toothpaste, which may be useful for optimizing its composition, manufacturing processing as well as end-user applications.

  16. Rejuvenation of Appalachian topography due to subsidence induced differential erosion

    NASA Astrophysics Data System (ADS)

    Liu, L.

    2014-12-01

    In ancient orogens, such as the Appalachian Mountains in the eastern United States, the difference between the high and low points—topographic relief—can continue to increase long after the tectonic forces that created the range have become inactive. Climatic forcing and mantle-induced dynamic uplift are proposed to drive formation of relief, but clear evidence is lacking in the Appalachian Mountains. Here I use a numerical simulation of dynamic topography in North America, combined with reconstructions of the sedimentation history from the Gulf of Mexico, to show that rejuvenation of topographic relief in the Appalachian Mountains since the Palaeogene period could have been caused by mantle-induced dynamic subsidence associated with sinking of the subducted Farallon slab. Specifically, I show that patterns of continental erosion and the eastward migration of sediment deposition centres in the Gulf of Mexico closely follow the locus of predicted dynamic subsidence. Furthermore, pulses of rapid sediment deposition in the Gulf of Mexico and western Atlantic correlate with enhanced erosion in the Appalachian Mountains during the Miocene epoch, caused by dynamic tilting of the continent. Calculations show that such subsidence-induced differential erosion caused flexural-isostatic adjustments of Appalachian topography that led to the development of both relief and elevation. I propose that dynamically induced continental tilting may provide a mechanism for topographic rejuvenation in ancient orogens.

  17. Rejuvenation of the Lithosphere by the Hawaiian Plume

    NASA Astrophysics Data System (ADS)

    Kind, R.; Li, X.; Yuan, X.; Woelbern, I.; Hanka, W.

    2003-12-01

    Thickness of oceanic lithosphere increases with distance from the ocean ridge due to cooling. If the lithosphere overrides a mantle plume, it will be modified. There exist several models describing the interaction of a plume with the lithosphere. However, existing seismic imaging techniques did not have sufficient resolution to decide for one of the models. We applied the S receiver function technique to data of three permanent seismic broadband stations on the Hawaiian islands to map the thickness of the lithosphere in so far unequaled detail. Under Big Island the lithosphere is 100-110 km thick, as expected for a 90-100 Myr old oceanic plate not modified by a plume. From there it is thinning gradually along the island chain to about 50-60 km below Kauai. The lithosphere retains its normal thickness in the region about 150 km to the north and to the south of the island chain, still well within the region of the topographic swell. Our data favour the rejuvenation model, in which the plume returns the lithosphere into conditions close to its origin at the mid ocean ridge. The maximum observed rejuvenation of the lithosphere at Kauai is delayed by about 3-4 Myr (the approximate age difference between Big Island and Kauai) and its thickness is nearly cut in half within that time.

  18. [Benefits of volumetric to facial rejuvenation. Part 1: Fat grafting].

    PubMed

    Bui, P; Lepage, C

    2017-09-05

    For a number of years, a volumetric approach using autologous fat injection has been implemented to improve cosmetic outcome in face-lift procedures and to achieve lasting rejuvenation. Autologous fat as filling tissue has been used in plastic surgery since the late 19th century, but has only recently been associated to face lift procedures. The interest of the association lies on the one hand in the pathophysiology of facial aging, involving skin sag and loss of volume, and on the other hand in the tissue induction properties of grafted fat, "rejuvenating" the injected area. The strict methodology consisting in harvesting, treating then injecting an autologous fat graft is known as LipoStructure(®) or lipofilling. We here describe the technique overall, then region by region. It is now well known and seems simple, effective and reproducible, but is nevertheless delicate. For each individual, it is necessary to restore a harmonious face with well-distributed volumes. By associating volumetric to the face lift procedure, the plastic surgeon plays a new role: instead of being a tailor, cutting away excess skin, he or she becomes a sculptor, remodeling the face to restore the harmony of youth. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  19. A possible mechanism for visible-light-induced skin rejuvenation

    NASA Astrophysics Data System (ADS)

    Longo, Leonardo; Lubart, Rachel; Friedman, Harry; Lavie, R.

    2004-09-01

    In recent years there has been intensive research in the field of non-ablative skin rejuvenation. This comes as a response to the desire for a simple method of treating rhytids caused by aging, UV exposure and acne scars. In numerous studies intense visible light pulsed systems (20-30J/cm2) are used. The mechanism of action was supposed to be a selective heat induced denaturalization of dermal collagen that leads to subsequent reactive synthesis. In this study we suggest a different mechanism for photorejuvenation based on light induced Reactive Oxygen Species (ROS) formation. We irradiated collagen in-vitro with a broad band of visible light, 400-800 nm, 12-22J/cm2, and used the spin trapping coupled with electron paramagnetic resonance (EPR) spectroscopy to detect ROS. In vivo, we used dose 30 J in average (35 for acnis scars, 25 for wrinkles and redness). Irradiated collagen results in hydroxyl and methyl radicals formation. We propose, as a new concept, that visible light at the intensity used for skin rejuvenation, 20-30J/cm2, produces high amounts of ROS which destroy old collagen fibers encouraging the formation of new ones. On the other hand at inner depths of the skin, where the light intensity is much weaker, low amounts of ROS are formed which are well known to stimulate fibroblast proliferation.

  20. Rejuvenating stem cells to restore muscle regeneration in aging

    PubMed Central

    Bengal, Eyal; Perdiguero, Eusebio; Serrano, Antonio L.; Muñoz-Cánoves, Pura

    2017-01-01

    Adult muscle stem cells, originally called satellite cells, are essential for muscle repair and regeneration throughout life. Besides a gradual loss of mass and function, muscle aging is characterized by a decline in the repair capacity, which blunts muscle recovery after injury in elderly individuals. A major effort has been dedicated in recent years to deciphering the causes of satellite cell dysfunction in aging animals, with the ultimate goal of rejuvenating old satellite cells and improving muscle function in elderly people. This review focuses on the recently identified network of cell-intrinsic and -extrinsic factors and processes contributing to the decline of satellite cells in old animals. Some studies suggest that aging-related satellite-cell decay is mostly caused by age-associated extrinsic environmental changes that could be reversed by a “youthful environment”. Others propose a central role for cell-intrinsic mechanisms, some of which are not reversed by environmental changes. We believe that these proposals, far from being antagonistic, are complementary and that both extrinsic and intrinsic factors contribute to muscle stem cell dysfunction during aging-related regenerative decline. The low regenerative potential of old satellite cells may reflect the accumulation of deleterious changes during the life of the cell; some of these changes may be inherent (intrinsic) while others result from the systemic and local environment (extrinsic). The present challenge is to rejuvenate aged satellite cells that have undergone reversible changes to provide a possible approach to improving muscle repair in the elderly. PMID:28163911

  1. X-ray decline and rejuvenation of a recurrent nova

    NASA Astrophysics Data System (ADS)

    Itoh, Hiroshi; Hachisu, Izumi

    1990-08-01

    The dynamical evolution and nonequilibrium X-ray emission of recurrent-nova remnants have been investigated by using a spherically symmetric hydrodynamic code. It is assummed that the nova ejecta expand into a wind from a red-giant companion. The wind material is blast shocked, and emits copious X-rays. The blast shock soon breaks out of the wind region which has formed since the previous outburst, and the remnant undergoes nearly unimpeded expansion. The rarefaction and adiabatic cooling of the remnant result in a drastic decline in the X-ray emission. At this stage the recombination exceeds the ionization, and the X-ray spectrum is characterized by strong recombination lines and continua. The blast shock eventually catches up with the relatively slow ejecta of the previous outbursts. The X-ray emission may then be rejuvenated in both luminosity and spectral shape. Observations of such an X-ray decline and rejuvenation may provide a clue to the outburst mechanism of recurrent novae.

  2. Extracellular Matrix Modulation: Optimizing Skin Care and Rejuvenation Procedures.

    PubMed

    Widgerow, Alan D; Fabi, Sabrina G; Palestine, Roberta F; Rivkin, Alexander; Ortiz, Arisa; Bucay, Vivian W; Chiu, Annie; Naga, Lina; Emer, Jason; Chasan, Paul E

    2016-04-01

    Normal aging and photoaging of the skin are chronic processes that progress gradually. The extracellular matrix (ECM), constituting over 70% of the skin, is the central hub for repair and regeneration of the skin. As such, the ECM is the area where changes related to photodamage are most evident. Degradation of the ECM with fragmentation of proteins significantly affects cross talk and signaling between cells, the matrix, and its constituents. The accumulation of collagen fragments, amorphous elastin agglutinations, and abnormal cross-linkages between the collagen fragments impedes the ECM from its normal repair and regenerative capacity, which manifests as wrinkled, non-elastic skin. Similar to how the chronic wound healing process requires wound bed preparation before therapeutic intervention, treatment of chronic aging of the skin would likely benefit from a "skin bed preparation" to optimize the outcome of rejuvenation procedures and skin maintenance programs. This involves introducing agents that can combat stress-induced oxidation, proteasome dysfunction, and non-enzymatic cross linkages involved in glycation end products, to collectively modulate this damaged ECM, and upregulate neocollagenesis and elastin production. Agents of particular interest are matrikines, peptides originating from the fragmentation of matrix proteins that exhibit a wide range of biological activities. Peptides of this type (tripeptide and hexapeptide) are incorporated in ALASTIN™ Skin Nectar with TriHex™ technology (ALASTIN Skincare, Inc., Carlsbad, CA), which is designed to target ECM modulation with a goal of optimizing results following invasive and non-invasive dermal rejuvenating procedures.

  3. Addressing anniversary reactions of trauma through group process: the Hurricane Katrina anniversary wellness workshops.

    PubMed

    Nemeth, Darlyne G; Kuriansky, Judy; Reeder, Kenneth P; Lewis, Amity; Marceaux, Kristin; Whittington, Taighlor; Olivier, Traci W; May, Natasha E; Safier, Jessica A

    2012-01-01

    Natural disasters such as Hurricane Katrina, which devastated the Gulf Coast of the United States in the summer of 2005, have highlighted the need to develop effective post-trauma psychotherapeutic intervention strategies, not only to deal with the immediate psychological aftermath of trauma, but also the long-term effects of anniversary reactions. Governmental responses to Hurricane Katrina relief were greatly criticized for disorganization and delay. Both immediately afterwards and in ensuing months, people's life needs often were not addressed. People-to-people individual and group grassroots efforts, including those provided by mental health professionals, however, did reach local communities to service immediate needs and long-term emotional reactions. The present paper describes one such effort designed to help survivors cope on the occasion of the first anniversary of Hurricane Katrina. Specifically, anniversary reaction group workshops were held to address unresolved emotional issues and to promote healing by encouraging belonging, comfort, security, and resilience. The ultimate goal of these wellness workshops was to assist participants in understanding and resolving their anniversary reactions. Preliminary quantitative and qualitative findings suggested that this workshop format helped participants face their anniversary reactions, address their related psychological sequelae, and deal with their physical displacement. Participants were then able to find the emotional strength to reattach, form new communities, and begin problem solving. These methods, with appropriate cultural modifications, were subsequently used in China, to assist Chinese mental health professionals prepare for the first anniversary of the Sichuan earthquake.

  4. Apollo 40th Anniversary Press Conference

    NASA Image and Video Library

    2009-08-11

    Eugene Cernan (Apollo 10, Apollo 17) , right, speaks, as Thomas Stafford (Apollo 10) looks on during the 40th anniversary of the Apollo 11 mission and the walk on the moon press conference, Monday, July 20, 2009, at NASA Headquarters in Washington Photo Credit: (NASA/Paul E. Alers)

  5. Apollo 40th Anniversary Morning Television

    NASA Image and Video Library

    2009-07-19

    Apollo astronaut Alan Bean, center, laughs at a comment made by Apollo astronaut Charles Duke, right, as Apollo astronaut Buzz Aldrin, left, looks on during a live television interview on Monday, July 20, 2009, at NASA Headquarters in Washington. Monday marked the 40th Anniversary of the historic landing of Apollo 11 on the Moon. Photo Credit: (NASA/Paul E. Alers)

  6. The Neglected Majority--20th Anniversary

    ERIC Educational Resources Information Center

    Beebe, Anthony E.; Walleri, R. Dan

    2005-01-01

    It is the 20th anniversary of the release of Dale Parnell's landmark book "The Neglected Majority". In this book, Parnell pointed out that for too long America's educational system has focused on the highest and lowest achievers. He made the case that most of those students in the middle two high school quartiles neither prepare for nor aspire to…

  7. Apollo 40th Anniversary Morning Television

    NASA Image and Video Library

    2009-07-19

    Apollo 11 astronaut Buzz Aldrin, the second man to walk on the Moon, responds to a question during a live television interview on Monday, July 20, 2009, at NASA Headquarters in Washington. Monday marked the 40th Anniversary of the historic landing. Photo Credit: (NASA/Paul E. Alers)

  8. Space agency notes 20th anniversary

    NASA Technical Reports Server (NTRS)

    Frosch, R. A.

    1978-01-01

    The twentieth anniversary of NASA is announced. A chronology of major milestones of the NASA program is given along with a brief outline of the programs and responsibilities of NASA Headquarters and the NASA centers and facilities. The NASA launch record is included.

  9. Hydration of Acetylene: A 125th Anniversary

    ERIC Educational Resources Information Center

    Ponomarev, Dmitry A.; Shevchenko, Sergey M.

    2007-01-01

    The year 2006 is the 125th anniversary of a chemical reaction, the discovery of which by Mikhail Kucherov had a profound effect on the development of industrial chemistry in the 19-20th centuries. This was the hydration of alkynes catalyzed by mercury ions that made possible industrial production of acetaldehyde from acetylene. Historical…

  10. Meteor Beliefs Project: The tenth anniversary

    NASA Astrophysics Data System (ADS)

    McBeath, Alastair

    2013-12-01

    An eclectic mixture of short items, some with an element of humour, concerning mostly meteoritic beliefs from texts and films, is presented to celebrate the Project's tenth anniversary, including material sent by contributors George Drobnock, John Naylor and Roy Watson. The Project's aims are reiterated, along with brief comments on future plans.

  11. Columbines 10th Anniversary Finds Lessons Learned

    ERIC Educational Resources Information Center

    Trump, Kenneth S.

    2009-01-01

    When school administrators hear that the 10th anniversary of the Columbine High School attack is approaching, most shake their heads in disbelief. They are amazed that 10 years have passed since this watershed event, which changed the landscape of K-12 school safety. In this article, the author reflects on the lessons learned from the Columbine…

  12. The First Reactor, 40th Anniversary (rev.)

    SciTech Connect

    Allardice, Corbin; Trapnell, Edward R; Fermi, Enrico; Fermi, Laura; Williams, Robert C

    1982-12-01

    This booklet, an updated version of the original booklet describing the first nuclear reactor, was written in honor of the 40th anniversary of the first reactor or "pile". It is based on firsthand accounts told to Corbin Allardice and Edward R. Trapnell, and includes recollections of Enrico and Laura Fermi.

  13. Hydration of Acetylene: A 125th Anniversary

    ERIC Educational Resources Information Center

    Ponomarev, Dmitry A.; Shevchenko, Sergey M.

    2007-01-01

    The year 2006 is the 125th anniversary of a chemical reaction, the discovery of which by Mikhail Kucherov had a profound effect on the development of industrial chemistry in the 19-20th centuries. This was the hydration of alkynes catalyzed by mercury ions that made possible industrial production of acetaldehyde from acetylene. Historical…

  14. Earthrise: The 45th Anniversary

    NASA Image and Video Library

    2017-09-27

    In December of 1968, the crew of Apollo 8 became the first people to leave our home planet and travel to another body in space. But as crew members Frank Borman, James Lovell, and William Anders all later recalled, the most important thing they discovered was Earth. Using photo mosaics and elevation data from Lunar Reconnaissance Orbiter (LRO), this video commemorates the 45th anniversary of Apollo 8's historic flight by recreating the moment when the crew first saw and photographed the Earth rising from behind the Moon. Narrator Andrew Chaikin, author of A Man on the Moon, sets the scene for a three-minute visualization of the view from both inside and outside the spacecraft accompanied by the onboard audio of the astronauts. The visualization draws on numerous historical sources, including the actual cloud pattern on Earth from the ESSA-7 satellite and dozens of photographs taken by Apollo 8, and it reveals new, historically significant information about the Earthrise photographs. It has not been widely known, for example, that the spacecraft was rolling when the photos were taken, and that it was this roll that brought the Earth into view. The visualization establishes the precise timing of the roll and, for the first time ever, identifies which window each photograph was taken from. The key to the new work is a set of vertical stereo photographs taken by a camera mounted in the Command Module's rendezvous window and pointing straight down onto the lunar surface. It automatically photographed the surface every 20 seconds. By registering each photograph to a model of the terrain based on LRO data, the orientation of the spacecraft can be precisely determined. Credit: NASA's Scientific Visualization Studio NASA image use policy. NASA Goddard Space Flight Center enables NASA’s mission through four scientific endeavors: Earth Science, Heliophysics, Solar System Exploration, and Astrophysics. Goddard plays a leading role in NASA’s accomplishments by contributing

  15. Noninvasive Facial Rejuvenation. Part 3: Physician-Directed—Lasers, Chemical Peels, and Other Noninvasive Modalities

    PubMed Central

    Meaike, Jesse D.; Agrawal, Nikhil; Chang, Daniel; Lee, Edward I.; Nigro, Marjory G.

    2016-01-01

    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin and rejuvenate damaged skin. Physicians may recommend and often prescribe certain products, but patients are in control with this type of facial rejuvenation. On the other hand, physician-directed facial rejuvenation entails modalities that require direct physician involvement, such as neuromodulators, filler injections, laser resurfacing, microdermabrasion, and chemical peels. With the successful integration of each of these modalities, a complete facial regimen can be established and patient satisfaction can be maximized. This article is the last in a three-part series describing noninvasive facial rejuvenation. Here the authors review the mechanism, indications, and possible complications of lasers, chemical peels, and other commonly used noninvasive modalities. PMID:27478423

  16. Noninvasive Facial Rejuvenation. Part 3: Physician-Directed-Lasers, Chemical Peels, and Other Noninvasive Modalities.

    PubMed

    Meaike, Jesse D; Agrawal, Nikhil; Chang, Daniel; Lee, Edward I; Nigro, Marjory G

    2016-08-01

    A proper knowledge of noninvasive facial rejuvenation is integral to the practice of a cosmetic surgeon. Noninvasive facial rejuvenation can be divided into patient- versus physician-directed modalities. Patient-directed facial rejuvenation combines the use of facial products such as sunscreen, moisturizers, retinoids, α-hydroxy acids, and various antioxidants to both maintain youthful skin and rejuvenate damaged skin. Physicians may recommend and often prescribe certain products, but patients are in control with this type of facial rejuvenation. On the other hand, physician-directed facial rejuvenation entails modalities that require direct physician involvement, such as neuromodulators, filler injections, laser resurfacing, microdermabrasion, and chemical peels. With the successful integration of each of these modalities, a complete facial regimen can be established and patient satisfaction can be maximized. This article is the last in a three-part series describing noninvasive facial rejuvenation. Here the authors review the mechanism, indications, and possible complications of lasers, chemical peels, and other commonly used noninvasive modalities.

  17. The Rejuvenating Effect in Hot Asphalt Recycling by Mortar Transfer Ratio and Image Analysis.

    PubMed

    Wang, Fusong; Wang, Zipeng; Li, Chao; Xiao, Yue; Wu, Shaopeng; Pan, Pan

    2017-05-24

    Using a rejuvenator to improve the performance of asphalt pavement is an effective and economic way of hot asphalt recycling. This research analyzes the rejuvenating effect on aged asphalt by means of a Mortar Transfer Ratio (MTR) test, which concerns the ratio of asphalt mortar that moves from recycled aggregates (RAP aggregates) to fresh added aggregates when aged asphalt is treated with a regenerating agent and comes into contact with fresh aggregates. The proposed MTR test analyzes the regeneration in terms of the softening degree on aged asphalt when the rejuvenator is applied. The covered area ratio is studied with an image analyzing tool to understand the possibility of mortar transferring from RAP aggregates to fresh aggregates. Additionally, a micro-crack closure test is conducted and observed through a microscope. The repairing ability and diffusion characteristics of micro-cracks can therefore be analyzed. The test results demonstrate that the proposed mortar transfer ratio is a feasible way to evaluate rejuvenator diffusion during hot recycling. The mortar transfer ratio and uncovered area ratio on fresh aggregates are compatible, and can be used to quantify the contribution of the rejuvenator. Within a certain temperature range, the diffusing effect of the rejuvenator is better when the diffusing temperature is higher. The diffusion time of the rejuvenator is optimum when diffusion occurs for 4-8 h. When the rejuvenator is properly applied, the rough and cracking surface can be repaired, resulting in better covered aggregates. The micro-closure analysis visually indicates that rejuvenators can be used to repair the RAP aggregates during hot recycling.

  18. The Rejuvenating Effect in Hot Asphalt Recycling by Mortar Transfer Ratio and Image Analysis

    PubMed Central

    Wang, Fusong; Wang, Zipeng; Li, Chao; Xiao, Yue; Wu, Shaopeng; Pan, Pan

    2017-01-01

    Using a rejuvenator to improve the performance of asphalt pavement is an effective and economic way of hot asphalt recycling. This research analyzes the rejuvenating effect on aged asphalt by means of a Mortar Transfer Ratio (MTR) test, which concerns the ratio of asphalt mortar that moves from recycled aggregates (RAP aggregates) to fresh added aggregates when aged asphalt is treated with a regenerating agent and comes into contact with fresh aggregates. The proposed MTR test analyzes the regeneration in terms of the softening degree on aged asphalt when the rejuvenator is applied. The covered area ratio is studied with an image analyzing tool to understand the possibility of mortar transferring from RAP aggregates to fresh aggregates. Additionally, a micro-crack closure test is conducted and observed through a microscope. The repairing ability and diffusion characteristics of micro-cracks can therefore be analyzed. The test results demonstrate that the proposed mortar transfer ratio is a feasible way to evaluate rejuvenator diffusion during hot recycling. The mortar transfer ratio and uncovered area ratio on fresh aggregates are compatible, and can be used to quantify the contribution of the rejuvenator. Within a certain temperature range, the diffusing effect of the rejuvenator is better when the diffusing temperature is higher. The diffusion time of the rejuvenator is optimum when diffusion occurs for 4–8 h. When the rejuvenator is properly applied, the rough and cracking surface can be repaired, resulting in better covered aggregates. The micro-closure analysis visually indicates that rejuvenators can be used to repair the RAP aggregates during hot recycling. PMID:28772935

  19. Copious, Long-lived Rejuvenated Volcanism in the Northern Hawaiian Islands

    NASA Astrophysics Data System (ADS)

    Garcia, M. O.; Weis, D.; Hanano, D. W.; Jicha, B. R.; Ito, G.

    2015-12-01

    New marine surveying and submersible sampling of Kaul'a Volcano, located 100 km off the axis of the Hawaiian Chain, have revealed widespread areas of young volcanism. New 40Ar/39Ar and geochemical analyses of the olivine-phyric submarine and subaerial volcanic rocks show that Kaul'a is shrouded with young alkalic basalts (1.9 to 0.5 Ma). The ages and chemistry of these rocks overlap with rejuvenated lavas from nearby shields Ni'ihau, Kaua'i and South Kaua'i Swell. Collectively, rejuvenated lavas cover a vast area (~7000 km2) in the northern Hawaiian Islands. Kaul'a rejuvenated lavas show a much larger (5x) variation of incompatible elements than those from adjacent Ni'ihau but comparable to Honolulu rejuvenated lavas. Unlike both suites, heavy REE elements in Kaul'a lavas are pinned at Ybn 10, indicating a strong garnet signature in the source. Rejuvenated lavas from the Kaua'i Ridge have slightly higher radiogenic Pb isotope ratios than those from the southern Hawaiian Islands (Maui to O'ahu) and partly straddle the LOA-KEA boundary. Rejuvenated volcanism was nearly coeval occurrence from ~0.3 to 0.6 Ma along a 450 km segment of the Hawaiian Islands (West Maui to north of Ni'ihau), which is inconsistent with most models for rejuvenated volcanism except the Ballmer et al.2 dynamic melting model. This model invokes increasing pyroxenite contributions and the interaction with scale-scale convection rolls in the lithosphere to enhance the volume and duration of rejuvenation volcanism. Thus, a pyroxenite-bearing, mixed Kea-Loa source component may have contributed to the prolonged and extensive rejuvenated volcanism in the northern Hawaiian Islands. 1Robinson & Eakins 2006, J. Vol. Geotherm. Res., 151, 309-317; 2Ballmer et al. 2011, Nat. Geosc. 4, 457-460.

  20. EDITORIAL: 50th anniversary issue

    NASA Astrophysics Data System (ADS)

    Beddoe, Alun H.

    2006-07-01

    In July 1956, 50 years ago, the first issue of Physics in Medicine and Biology (PMB) was published. It was subtitled The Journal of the Hospital Physicists' Association and published in association with the Philosophical Magazine by Taylor and Francis. Subscriptions were £1 per part or £3 10s for an annual subscription. The Editor, Professor J E Roberts, prefaced the first issue with a cautious editorial noting: The appearance of a new journal is usually greeted with mixed feelings by scientific workers, a common response being that there are far too many journals already. Justification for a new publication is only possible if there is a clearly defined gap in the publishing facilities available to workers in a particular scientific field.... Professor Roberts ended by seeking support from the scientific community for the new venture. He certainly got it! From a tentative few hundred pages in four issues a year for the first few years, the journal is now issued twice monthly with nearly 8000 pages expected in volume 51. In this anniversary issue we have invited some 28 senior authors to submit papers on a range of subjects spanning the discipline. We decided that to be an author one had to be old, but age was not to be the only criterion! Indeed readers will recognize all names as major contributors to both the development of medical physics and the success of PMB. Authors were not asked to write formal topical reviews of the state-of-the-art of the sub-disciplines which make up medical physics, but rather to present short historical reviews, didactic in style, perhaps highlighting the role of PMB in the development of their fields. Nevertheless, other than a page limit (which many subsequently ignored!) no formal format was imposed on authors, so what follows is a range of contributions from the almost conversational, personal statement to the more formal and familiar scientific paper. Whatever the writing style we are confident that readers will gain some

  1. Rejuvenation of the neck with liposuction and ancillary techniques.

    PubMed

    Stebbins, William G; Hanke, C William

    2011-01-01

    An aesthetically pleasing neck is an important component of physical appearance and a frequently targeted area for a variety of rejuvenative procedures. In appropriately selected patients, liposuction of the neck using tumescent local anesthesia can effectively render a more youthful appearance to the anterior and lateral neck by removing superficial adipose tissue and redraping the skin. This article will review all aspects of neck liposuction, including neck and lower face anatomy, proper patient selection and evaluation, necessary equipment, as well as all peri-procedural management. An in-depth discussion of administration of tumescent local anesthesia and proper liposuction technique is also included. Lastly, a number of ancillary techniques to further enhance the appearance of the neck including laser lipolysis, fractional ablative CO(2) resurfacing, and treatment of platysmal banding will be briefly discussed. © 2011 Wiley Periodicals, Inc.

  2. [The opportunities, challenges and trends in the rejuvenation of microbiology].

    PubMed

    Shen, Ping; Chen, Xiangdong

    2010-01-01

    In history, the development of microbiology had undergone two golden ages and some depression time as well. In the last two decades, the application of many physiochemical technologies including genomics, structural biology, bioinformatics, PCR, and high-resolution microscopy has led to a series of breakthroughs in microbiology. Microbiology has now awakened and entered its third golden age for development. This review discusses our view of the opportunities, challenges, and trends in the current advancement of microbiology. The topics include: (1) The two golden ages for microbiology in history. (2) The opportunities and challenges in the rejuvenation of microbiology. (3) The characteristics and trends of the current development of microbiology. (4) Integral microbiology--the hallmark of the third golden age.

  3. Rejuvenation and recovery of electroplating acids using the WADR technology

    SciTech Connect

    Jones, E.O.; Litt, R.D.; Chauhan, S.

    1994-10-01

    Acid baths at the US Air Force/Oklahoma City Air Logistic Center (OC-ALC) will be rejuvenated by the use of a new technology -- Waste Acid Detoxification and Reclamation (WADR), a distillation process that concentrates the metals and creates a clean reusable acid. The concentrated metals are recovered for disposal or recycling. A 200-gallon batch prototype system will be installed and demonstrated on HCl, HNO{sub 3} and H{sub 2}SO{sub 4} baths at OC-ALC`s electroplating shop in late 1994. The system was tested in the summer of 1994 with typical industrial spent acids. The WADR system is expected to reduce waste from the OC-ALC acid baths by 80% to 90% as compared with current treatment operations. Laboratory test results and the prototype system design are presented here. The technology is expected to meet the needs of various industries generating spent acids with increasing disposal costs.

  4. The use of botulinum toxin A in perioral rejuvenation.

    PubMed

    Kaplan, Seth E; Sherris, David A; Gassner, Holger G; Friedman, Oren

    2007-11-01

    Botulinum toxin A is an effective and safe treatment for perioral rejuvenation. This article explores the application of this toxin for cosmetic use in the perioral region, facial asymmetry, and improved facial wound healing. This article also describes how the use of botulinum toxin A, which has traditionally been used on the upper one third of the face, has expanded to the lower two thirds with the advent of a new formulation that consists of botulinum toxin combined with an anesthetic agent and a vasoconstrictor. The new formula provides the injecting physician with immediate feedback on the eventual treatment effect and reduces local diffusion of the simultaneously injected agents, potentially limiting systemic absorption and diffusion to neighboring muscle groups and adding to an already remarkable safety profile.

  5. Aging, Clonality and Rejuvenation of Hematopoietic Stem Cells

    PubMed Central

    Akunuru, Shailaja; Geiger, Hartmut

    2016-01-01

    Aging is associated with reduced organ function and increased disease incidence. Hematopoietic stem cell (HSC) aging driven by both cell intrinsic and extrinsic factors is linked to impaired HSC self-renewal and regeneration, aging-associated immune remodeling, and increased leukemia incidence. Compromised DNA damage responses and increased production of reactive oxygen species have been previously causatively attributed to HSC aging. However, recent paradigm-shifting concepts such as global epigenetic and cytoskeletal polarity shifts, cellular senescence, as well as clonal selection of HSCs upon aging provide new insights into HSC aging mechanisms. Rejuvenating agents that can reprogram the epigenetic status of aged HSCs or senolytic drugs that selectively deplete senescent cells provide promising translational avenues for attenuating hematopoietic aging and potentially, alleviating aging-associated immune remodeling and myeloid malignancies. PMID:27380967

  6. Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells.

    PubMed

    Akunuru, Shailaja; Geiger, Hartmut

    2016-08-01

    Aging is associated with reduced organ function and increased disease incidence. Hematopoietic stem cell (HSC) aging driven by both cell intrinsic and extrinsic factors is linked to impaired HSC self-renewal and regeneration, aging-associated immune remodeling, and increased leukemia incidence. Compromised DNA damage responses and the increased production of reactive oxygen species (ROS) have been previously causatively attributed to HSC aging. However, recent paradigm-shifting concepts, such as global epigenetic and cytoskeletal polarity shifts, cellular senescence, as well as the clonal selection of HSCs upon aging, provide new insights into HSC aging mechanisms. Rejuvenating agents that can reprogram the epigenetic status of aged HSCs or senolytic drugs that selectively deplete senescent cells provide promising translational avenues for attenuating hematopoietic aging and, potentially, alleviating aging-associated immune remodeling and myeloid malignancies. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Rejuvenation of human cardiac progenitor cells with Pim-1 kinase.

    PubMed

    Mohsin, Sadia; Khan, Mohsin; Nguyen, Jonathan; Alkatib, Monique; Siddiqi, Sailay; Hariharan, Nirmala; Wallach, Kathleen; Monsanto, Megan; Gude, Natalie; Dembitsky, Walter; Sussman, Mark A

    2013-10-25

    Myocardial function is enhanced by adoptive transfer of human cardiac progenitor cells (hCPCs) into a pathologically challenged heart. However, advanced age, comorbidities, and myocardial injury in patients with heart failure constrain the proliferation, survival, and regenerative capacity of hCPCs. Rejuvenation of senescent hCPCs will improve the outcome of regenerative therapy for a substantial patient population possessing functionally impaired stem cells. Reverse phenotypic and functional senescence of hCPCs by ex vivo modification with Pim-1. C-kit-positive hCPCs were isolated from heart biopsy samples of patients undergoing left ventricular assist device implantation. Growth kinetics, telomere lengths, and expression of cell cycle regulators showed significant variation between hCPC isolated from multiple patients. Telomere length was significantly decreased in hCPC with slow-growth kinetics concomitant with decreased proliferation and upregulation of senescent markers compared with hCPC with fast-growth kinetics. Desirable youthful characteristics were conferred on hCPCs by genetic modification using Pim-1 kinase, including increases in proliferation, telomere length, survival, and decreased expression of senescence markers. Senescence characteristics of hCPCs are ameliorated by Pim-1 kinase resulting in rejuvenation of phenotypic and functional properties. hCPCs show improved cellular properties resulting from Pim-1 modification, but benefits were more pronounced in hCPC with slow-growth kinetics relative to hCPC with fast-growth kinetics. With the majority of patients with heart failure presenting advanced age, infirmity, and impaired regenerative capacity, the use of Pim-1 modification should be incorporated into cell-based therapeutic approaches to broaden inclusion criteria and address limitations associated with the senescent phenotype of aged hCPC.

  8. Rejuvenation of Human Cardiac Progenitor Cells With Pim-1 Kinase

    PubMed Central

    Mohsin, Sadia; Khan, Mohsin; Nguyen, Jonathan; Alkatib, Monique; Siddiqi, Sailay; Hariharan, Nirmala; Wallach, Kathleen; Monsanto, Megan; Gude, Natalie; Dembitsky, Walter; Sussman, Mark A.

    2014-01-01

    Rationale Myocardial function is enhanced by adoptive transfer of human cardiac progenitor cells (hCPCs) into a pathologically challenged heart. However, advanced age, comorbidities, and myocardial injury in patients with heart failure constrain the proliferation, survival, and regenerative capacity of hCPCs. Rejuvenation of senescent hCPCs will improve the outcome of regenerative therapy for a substantial patient population possessing functionally impaired stem cells. Objective Reverse phenotypic and functional senescence of hCPCs by ex vivo modification with Pim-1. Methods and Results C-kit–positive hCPCs were isolated from heart biopsy samples of patients undergoing left ventricular assist device implantation. Growth kinetics, telomere lengths, and expression of cell cycle regulators showed significant variation between hCPC isolated from multiple patients. Telomere length was significantly decreased in hCPC with slow-growth kinetics concomitant with decreased proliferation and upregulation of senescent markers compared with hCPC with fast-growth kinetics. Desirable youthful characteristics were conferred on hCPCs by genetic modification using Pim-1 kinase, including increases in proliferation, telomere length, survival, and decreased expression of senescence markers. Conclusions Senescence characteristics of hCPCs are ameliorated by Pim-1 kinase resulting in rejuvenation of phenotypic and functional properties. hCPCs show improved cellular properties resulting from Pim-1 modification, but benefits were more pronounced in hCPC with slow-growth kinetics relative to hCPC with fast-growth kinetics. With the majority of patients with heart failure presenting advanced age, infirmity, and impaired regenerative capacity, the use of Pim-1 modification should be incorporated into cell-based therapeutic approaches to broaden inclusion criteria and address limitations associated with the senescent phenotype of aged hCPC. PMID:24044948

  9. Characterization of photorespiration and photosynthesis in soybean cotyledons during seedling development, cotyledon senescence and rejuvenation

    SciTech Connect

    Marek, L.F.

    1988-01-01

    We measured light and dark carbon dioxide exchange rates (CER) in germinating, presenescent, and senescing soybean cotyledons and in cotyledons rejuvenated by epicotyl removal on different days after planting. In other aspects of cotyledon physiology, we observed significant differences between rejuvenated and presenescent soybean cotyledons. Rejuvenated cotyledons accumulated chlorophyll to levels greater than the maximal amount measured in presenescent cotyledons. A second difference was the observation that during rejuvenation, the post-illumination outburst of CO{sub 2} (the PIB), a qualitative indication of photorespiration, appeared to recover more slowly than light CER when compared with presenescent but equivalent light CERs. To investigate the relationship between the PIB and light CER, we labelled cotyledons with {sup 14}CO{sub 2} during photosynthesis. We measured the amount of ribulose-1,5-bisphosphate carboxylase oxygenase (RubisCO) in the cotyledons by rocket immunoelectrophoresis.

  10. Predicting gully rejuvenation after wildfire using remotely sensed burn severity data

    NASA Astrophysics Data System (ADS)

    Hyde, Kevin; Woods, Scott W.; Donahue, Jack

    2007-05-01

    The loss of surface vegetation and reduced infiltration caused by wildfires can trigger gully rejuvenation, resulting in damage to downstream aquatic resources and risk to human life and property. We developed a spatially explicit metric of burn severity — the Burn Severity Distribution Index (BSDI) — and tested its ability to predict post-fire gully rejuvenation in 1st and 2nd order basins burned in the 2000 Valley Complex fires in the Sapphire Mountains of western Montana. The BSDI was derived from burn severity data interpreted from Landsat 7 satellite imagery using the Normalized Burn Ratio (NBR) method, and ranged from 0.0 for completely unburned basins to 4.0 for basins burned entirely at high severity. In July 2001 rainstorms with peak 30-minute intensities of up to 17 mm h - 1 triggered gully rejuvenation in 66 of the 171 basins examined. The frequency of gully rejuvenation was higher in basins with higher BSDI values, increasing from zero for basins with a BSDI less than 1.3 to 67% for basins with a BSDI greater than 3.0. Binary logistic regression indicated that BSDI was a more significant predictor of gully rejuvenation than basin morphometric variables. The absence of gully rejuvenation in several basins with a high BSDI was attributed to low gradient, dense riparian vegetation, or concentration of high burn severity at lower elevations in the basin. The presence of gully rejuvenation in several basins with a low BSDI was associated with false negative NBR classification errors in northwest aspects, and concentration of severe burn impacts in the drainage headslopes. BSDI is a useful metric for predicting gully rejuvenation after wildfire. The use of the BSDI in Burned Area Emergency Response team assessments could improve the planning, implementation, and monitoring of burned area recovery treatments.

  11. Apollo 40th Anniversary Press Conference

    NASA Image and Video Library

    2009-07-19

    Apollo astronauts from left, Walt Cunningham (Apollo 17), James Lovell (Apollo 8 Apollo 13), David Scott (Apollo 9 Apollo 15), Buzz Aldrin (Apollo 11), Charles Duke (Apollo 16), Thomas Stafford (Apollo 10) and Eugene Cernan (Apollo 17) are seen during the 40th anniversary of the Apollo 11 mission and the walk on the moon press conference, Monday, July 20, 2009, at NASA Headquarters in Washington. Photo Credit: (NASA/Paul E. Alers)

  12. Apollo 40th Anniversary Morning Television

    NASA Image and Video Library

    2009-07-19

    Apollo 11 astronaut Buzz Aldrin, the second man to walk on the Moon, seated left, responds to a question during a live television interview on Monday, July 20, 2009, at NASA Headquarters in Washington as Apollo 12 astronaut Alan Bean and Apollo 16 astronaut Charles Duke, right look on. The three sat in for interviews with morning talks shows covering the 40th Anniversary of the Apollo 11 landing on the Moon. Photo Credit: (NASA/Paul E. Alers)

  13. 'Recharge my exhausted batteries': Overbeck's Rejuvenator, Patenting, and Public Medical Consumers, 1924-37.

    PubMed

    Stark, James F

    2014-10-01

    Although historians have shown that there has been a complex and multi-layered relationship between the body, medicine and the force of electricity, many avenues remain to be explored. One of the most prominent of these is the way in which electrotherapy technologies were marketed to a wide variety of different end users and intermediaries. This paper offers the first historical analysis of one such device - the Overbeck Rejuvenator - a 1920s electrotherapy machine designed for use by the general public. Its inventor, Otto Overbeck, was not a medical man and this enabled him to use aggressive strategies of newspaper advertising, using testimonials to market his product alongside appeals to his own scientific authority. He commissioned the prestigious Ediswan Company to manufacture the Rejuvenator on a large scale, and took out patents in eleven countries to persuade users of the efficacy of the device. In response to Overbeck's activities, the British Medical Association enlisted an electrical engineer to examine the Rejuvenator, contacted practitioners whose endorsements were being used in publicity material, and denied Overbeck permission to advertise in the British Medical Journal. Despite this, the Rejuvenator brought its inventor wealth and notoriety, and helped redefine the concept of 'rejuvenation', even if the professional reception of such a device was almost universally hostile. This paper shows how the marketing, patenting and publishing of Overbeck combined to persuade members of the laity to try the Rejuvenator as an alternative form of therapy, bypassing the medical profession in the process.

  14. Preparation of capsules containing rejuvenators for their use in asphalt concrete.

    PubMed

    García, Alvaro; Schlangen, Erik; van de Ven, Martin; Sierra-Beltrán, Guadalupe

    2010-12-15

    Every year, there is a demand of more than 110 million metric tons of asphalt all around the world. This represents a huge amount of money and energy, from which a good part is for the preservation and renovation of the existing pavements. The problem of asphalt is that it oxidizes with time and therefore its beneficial properties disappear. Traditionally, rejuvenators spread in the road surface, are used to restore the original properties of the pavement. The problem is that, for a rejuvenator to be successful, it must penetrate the pavement surface. Furthermore, application of a rejuvenator will reduce the skid resistance of the pavement and, besides, rejuvenators have many aromatic compounds that can be harmful for the environment. To solve these problems this paper introduces a new concept in road construction: encapsulated rejuvenators. The basic principle is that when the stress in capsules embedded in the asphalt reaches a certain threshold value, the capsules break and some rejuvenator is released, restoring the original properties of the pavement. This paper will show how to prepare such capsules and how to determine their characteristics. This is one of the first steps towards intelligent pavements.

  15. JANNAF 25th Airbreathing Propulsion Subcommittee, 37th Combustion Subcommittee and 1st Modeling and Simulation Subcommittee Joint Meeting. Volume 1

    NASA Technical Reports Server (NTRS)

    Fry, Ronald S.; Becker, Dorothy L.

    2000-01-01

    Volume I, the first of three volumes, is a compilation of 24 unclassified/unlimited-distribution technical papers presented at the Joint Army-Navy-NASA-Air Force (JANNAF) 25th Airbreathing Propulsion Subcommittee, 37th Combustion Subcommittee and 1st Modeling and Simulation Subcommittee (MSS) meeting held jointly with the 19th Propulsion Systems Hazards Subcommittee. The meeting was held 13-17 November 2000 at the Naval Postgraduate School and Hyatt Regency Hotel, Monterey, California. Topics covered include: a Keynote Address on Future Combat Systems, a review of the new JANNAF Modeling and Simulation Subcommittee, and technical papers on Hyper-X propulsion development and verification; GTX airbreathing launch vehicles; Hypersonic technology development, including program overviews, fuels for advanced propulsion, ramjet and scramjet research, hypersonic test medium effects; and RBCC engine design and performance, and PDE and UCAV advanced and combined cycle engine technologies.

  16. Clinical study of the necessity of replanning before the 25th fraction during the course of intensity-modulated radiotherapy for patients with nasopharyngeal carcinoma.

    PubMed

    Wang, Wei; Yang, Haihua; Hu, Wei; Shan, Guoping; Ding, Weijun; Yu, Changhui; Wang, Biyun; Wang, Xufeng; Xu, Qianyi

    2010-06-01

    To quantify the target and normal structures on dose distributing variations during intensity-modulated radiotherapy (IMRT) and to assess the value of replanning for nasopharyngeal carcinoma (NPC) patients. Twenty-eight NPC patients treated with IMRT were recruited. The IMRT was delivered in 33 fractions, to 70 to 76Gy, to the gross tumor volume (GTV). Before the 25th fraction of IMRT, a new simulation computed tomography (CT) scan was acquired for all patients. According to the dose constraint criterion in the Radiation Therapy Oncology Group (RTOG) 0225 protocol, the replanning was generated on the new simulation CT. With the Quality Assessment Center of a CORVUS 6.3 treatment planning system, a phantom plan was generated for each patient by applying the beam configurations of the initial plan to the anatomy of the new simulation CT. The dose-volume histograms of the phantom plan were compared with the replanning. The percentage of prescription dose delivered to the clinical target volume (CTV1) was significantly increased by 4.91% +/- 10.89%, whereas the maximum dose to the spinal cord, mean dose to the left parotid, and V30 to the right parotid were significantly decreased by 5.00 +/- 9.23Gy, 4.23 +/- 10.03Gy, and 11.47% +/- 18.89% respectively in the replanning, compared with the phantom plan (p < 0.05). Based on the dose constraint criterion in the RTOG0225 protocol, 50% of phantom plans (14/28) were out of limit for the dose to the normal critical structures, whereas no plan was out of limit in replanning (p < 0.001). Replanning for patients with NPC before the 25th fraction during IMRT helps to ensure adequate dose to the target volumes and safe doses to critical normal structures. Copyright 2010 Elsevier Inc. All rights reserved.

  17. 60th anniversary of state sanitary inspection and 95th anniversary of sanitary services in Poland.

    PubMed

    Posobkiewicz, Marek; Kalinowska-Morka, Joanna; Świekatowski, Bartosz

    2015-01-01

    2014 was a year of two jubilees in the remit of public health in Poland: 95th anniversary of sanitary services and 60th anniversary of State Sanitary Inspection. It was an opportunity to organize a conference so as to remind the events concerning a birth of the institution which, after the First World War, had originated structures of epidemiological and sanitary supervision in Poland, the one we have nowadays. A conference took place on 16th December 2014 in Warsaw, at Palladium Theatre.

  18. Rejuvenating cellular respiration for optimizing respiratory function: targeting mitochondria.

    PubMed

    Agrawal, Anurag; Mabalirajan, Ulaganathan

    2016-01-15

    Altered bioenergetics with increased mitochondrial reactive oxygen species production and degradation of epithelial function are key aspects of pathogenesis in asthma and chronic obstructive pulmonary disease (COPD). This motif is not unique to obstructive airway disease, reported in related airway diseases such as bronchopulmonary dysplasia and parenchymal diseases such as pulmonary fibrosis. Similarly, mitochondrial dysfunction in vascular endothelium or skeletal muscles contributes to the development of pulmonary hypertension and systemic manifestations of lung disease. In experimental models of COPD or asthma, the use of mitochondria-targeted antioxidants, such as MitoQ, has substantially improved mitochondrial health and restored respiratory function. Modulation of noncoding RNA or protein regulators of mitochondrial biogenesis, dynamics, or degradation has been found to be effective in models of fibrosis, emphysema, asthma, and pulmonary hypertension. Transfer of healthy mitochondria to epithelial cells has been associated with remarkable therapeutic efficacy in models of acute lung injury and asthma. Together, these form a 3R model--repair, reprogramming, and replacement--for mitochondria-targeted therapies in lung disease. This review highlights the key role of mitochondrial function in lung health and disease, with a focus on asthma and COPD, and provides an overview of mitochondria-targeted strategies for rejuvenating cellular respiration and optimizing respiratory function in lung diseases. Copyright © 2016 the American Physiological Society.

  19. Aging and rejuvenation of active matter under topological constraints

    DOE PAGES

    Janssen, Liesbeth M. C.; Kaiser, Andreas; Lowen, Hartmut

    2017-07-18

    The coupling of active, self-motile particles to topological constraints can give rise to novel nonequilibrium dynamical patterns that lack any passive counterpart. Here we study the behavior of self-propelled rods confined to a compact spherical manifold by means of Brownian dynamics simulations. We establish the state diagram and find that short active rods at sufficiently high density exhibit a glass transition toward a disordered state characterized by persistent self-spinning motion. By periodically melting and revitrifying the spherical spinning glass, we observe clear signatures of time-dependent aging and rejuvenation physics. We quantify the crucial role of activity in these nonequilibrium processes,more » and rationalize the aging dynamics in terms of an absorbing-state transition toward a more stable active glassy state. In conclusion, our results demonstrate both how concepts of passive glass phenomenology can carry over into the realm of active matter, and how topology can enrich the collective spatiotemporal dynamics in inherently non-equilibrium systems.« less

  20. Rejuvenation of the lithosphere by the Hawaiian plume

    NASA Astrophysics Data System (ADS)

    Li, Xueqing; Kind, Rainer; Yuan, Xiaohui; Wölbern, Ingo; Hanka, Winfried

    2004-02-01

    The volcanism responsible for creating the chain of the Hawaiian islands and seamounts is believed to mark the passage of the oceanic lithosphere over a mantle plume. In this picture hot material rises from great depth within a fixed narrow conduit to the surface, penetrating the moving lithosphere. Although a number of models describe possible plume-lithosphere interactions, seismic imaging techniques have not had sufficient resolution to distinguish between them. Here we apply the S-wave `receiver function' technique to data of three permanent seismic broadband stations on the Hawaiian islands, to map the thickness of the underlying lithosphere. We find that under Big Island the lithosphere is 100-110km thick, as expected for an oceanic plate 90-100 million years old that is not modified by a plume. But the lithosphere thins gradually along the island chain to about 50-60km below Kauai. The width of the thinning is about 300km. In this zone, well within the larger-scale topographic swell, we infer that the rejuvenation model (where the plume thins the lithosphere) is operative; however, the larger-scale topographic swell is probably supported dynamically.

  1. Logging system adds value to field rejuvenation efforts

    SciTech Connect

    Peters, D.; Bartenhagen, K.; Santolamazza, A.

    1997-11-01

    As with any rejuvenation scheme, the first step is always identification and evaluation of potential producible reserves. But economic and physical factors made evaluation using traditional logging techniques problematic. The constraints that inhibited earlier logging tools have been addressed by a new, compact integrated system called Platform Express (PEX). Oil companies operating in two of the most mature producing regions of the US, the Hugoton-Panhandle Field and the Southwest Nena Lucia Field in West Texas, discuss the physical and economic advantages they are reaping using PEX technologies. Hugoton-Panhandle Field, discovered around 1920, sprawls across parts of three south-central states and has been one of the world`s largest gas producers. Despite continuing pressure declines in this aging gas giant, the entire region has undergone restoration in the last few years. In its Kansas portions, a modest oil production has almost doubled since 1990 and a steep gas decline has been completely turned around. These production gains have come from an active program of recompletions, the deepening of old holes and new drilling. The story in the southwest Nena Lucia Field is much the same. Operator Oryx Energy has been active in the field, located west of Abilene, Texas, since its discovery in the 1950s. The goal with this field is to use advanced technologies to reverse the production declines that began years ago. Such a reversal began in mid-1996 and has been sustained thus far.

  2. The Impracticality of Biomedical Rejuvenation Therapies: Translational and Pharmacological Barriers

    PubMed Central

    2014-01-01

    Abstract Editor's Note: A response to this article from Aubrey de Grey, Editor-in-Chief, can be found on pages 397–400 in this issue. The notion that it is possible to eradicate age-related degeneration and live a life with a negligible rate of senescence solely by using a physical “repair-oriented” approach is flawed on a number of fronts. Here, I will argue that there are so many unknown variables embedded in this line of thinking that make the final result impossible to predict. Two relatively easy-to-research areas are the search for successful cross-link breakers and an effective lysosomal degradation therapy. A more complex and speculative strategy is whole-body interdiction of lengthening of telomeres (WILT). Highlighting these as examples, I argue that it is unlikely that such rejuvenation biotechnologies will be used meaningfully by the general public. The discussion assumes that although such therapies may in theory one day be developed in the laboratory, and even possibly be formulated as physical clinical therapies, these will be unusable in practical terms when applied upon humans at large. Due to inherent characteristics of our biological, evolutionary, and psychological heritage, it is implausible that curing aging will occur by using physical interventions alone. PMID:25072550

  3. Peripheral mononuclear cell rejuvenation for senescence surveillance in Alzheimer disease.

    PubMed

    Malavolta, Marco; Basso, Andrea; Piacenza, Francesco; Costarelli, Laura; Giacconi, Robertina; Mocchegiani, Eugenio

    2013-01-01

    Recent observations have pointed out that microglia, astrocytes and cerebrovascular endothelial cells senescence might contribute to the onset or progression of sporadic AD. The accumulation of senescent dysfunctional microglia or senescence related changes of other cells within CNS could be causally implicated in AD and age-related dysfunction and their efficient removal could represent a pivotal mechanism to prevent or delay neurodegeneration. The question how senescent cells are cleared from CNS has been poorly investigated, even though it is reasonable to believe that resident microglia is involved in this task. However, accumulating evidence now support the idea that assistance by peripheral mononuclear phagocytes (MP) in AD could be essential to control local brain inflammation and remove Abeta depots. Based on the current knowledge it is reasonable to hypothesize that senescence surveillance might be among the tasks that blood derived MP are called to envelop in the CNS during particular conditions, especially in the case senescent microglia is not able to achieve this task properly. However, age-related dysfunctions of these players of innate immunity could lead to depict a series of events that synergically with microglia and other CNS cells senescence could lead to a rapid progression of the disease. Hence, the design of intervention aimed at targeting accumulating senescent cells by rejuvenation of peripheral MP function seems an attractive tool that perhaps would also help to clarify the processes involved in senescence surveillance in normal and AD brain.

  4. The rejuvenating effect of pregnancy on muscle regeneration.

    PubMed

    Falick Michaeli, Tal; Laufer, Neri; Sagiv, Jitka Yehudit; Dreazen, Avigail; Granot, Zvi; Pikarsky, Eli; Bergman, Yehudit; Gielchinsky, Yuval

    2015-08-01

    Aging is characterized by reduced tissue regenerative capacity attributed to a diminished responsiveness of tissue-specific stem cells. With increasing age, resident precursor cells in muscle tissues show a markedly impaired propensity to proliferate in response to damage. However, exposure to factors present in the serum of young mice restores the regenerative capacity of aged precursor cells. As pregnancy represents a unique biological model of a partially shared blood system between young and old organisms, we hypothesized that pregnancy in aged mice would have a rejuvenating effect on the mother. To test this hypothesis, we assessed muscle regeneration in response to injury in young and aged pregnant and nonpregnant mice. Muscle regeneration in the aged pregnant mice was improved relative to that in age-matched nonpregnant mice. The beneficial effect of pregnancy was transient, lasting up to 2 months after delivery, and appeared to be attributable to activation of satellite cells via the Notch signaling pathway, thus supporting the possibility that pregnancy induces activation of aged dormant muscle progenitor cells.

  5. The rejuvenating effect of pregnancy on muscle regeneration

    PubMed Central

    Falick Michaeli, Tal; Laufer, Neri; Sagiv, Jitka Yehudit; Dreazen, Avigail; Granot, Zvi; Pikarsky, Eli; Bergman, Yehudit; Gielchinsky, Yuval

    2015-01-01

    Aging is characterized by reduced tissue regenerative capacity attributed to a diminished responsiveness of tissue-specific stem cells. With increasing age, resident precursor cells in muscle tissues show a markedly impaired propensity to proliferate in response to damage. However, exposure to factors present in the serum of young mice restores the regenerative capacity of aged precursor cells. As pregnancy represents a unique biological model of a partially shared blood system between young and old organisms, we hypothesized that pregnancy in aged mice would have a rejuvenating effect on the mother. To test this hypothesis, we assessed muscle regeneration in response to injury in young and aged pregnant and nonpregnant mice. Muscle regeneration in the aged pregnant mice was improved relative to that in age-matched nonpregnant mice. The beneficial effect of pregnancy was transient, lasting up to 2 months after delivery, and appeared to be attributable to activation of satellite cells via the Notch signaling pathway, thus supporting the possibility that pregnancy induces activation of aged dormant muscle progenitor cells. PMID:25773509

  6. Rejuvenation of the lithosphere by the Hawaiian plume.

    PubMed

    Li, Xueqing; Kind, Rainer; Yuan, Xiaohui; Wölbern, Ingo; Hanka, Winfried

    2004-02-26

    The volcanism responsible for creating the chain of the Hawaiian islands and seamounts is believed to mark the passage of the oceanic lithosphere over a mantle plume. In this picture hot material rises from great depth within a fixed narrow conduit to the surface, penetrating the moving lithosphere. Although a number of models describe possible plume-lithosphere interactions, seismic imaging techniques have not had sufficient resolution to distinguish between them. Here we apply the S-wave 'receiver function' technique to data of three permanent seismic broadband stations on the Hawaiian islands, to map the thickness of the underlying lithosphere. We find that under Big Island the lithosphere is 100-110 km thick, as expected for an oceanic plate 90-100 million years old that is not modified by a plume. But the lithosphere thins gradually along the island chain to about 50-60 km below Kauai. The width of the thinning is about 300 km. In this zone, well within the larger-scale topographic swell, we infer that the rejuvenation model (where the plume thins the lithosphere) is operative; however, the larger-scale topographic swell is probably supported dynamically.

  7. Anti-ageing and rejuvenating effects of quercetin.

    PubMed

    Chondrogianni, Niki; Kapeta, Suzanne; Chinou, Ioanna; Vassilatou, Katerina; Papassideri, Issidora; Gonos, Efstathios S

    2010-10-01

    Homeostasis is a key feature of the cellular lifespan. Its maintenance influences the rate of ageing and it is determined by several factors, including efficient proteolysis. The proteasome is the major cellular proteolytic machinery responsible for the degradation of both normal and damaged proteins. Alterations of proteasome function have been recorded in various biological phenomena including ageing and replicative senescence. Proteasome activities and function are decreased upon replicative senescence, whereas proteasome activation confers enhanced survival against oxidative stress, lifespan extension and maintenance of the young morphology longer in human primary fibroblasts. Several natural compounds possess anti-ageing/anti-oxidant properties. In this study, we have identified quercetin (QUER) and its derivative, namely quercetin caprylate (QU-CAP) as a proteasome activator with anti-oxidant properties that consequently influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts. Moreover, when these compounds are supplemented to already senescent fibroblasts, a rejuvenating effect is observed. Finally, we show that these compounds promote physiological alterations when applied to cells (i.e. whitening effect). In summary, these data demonstrate the existence of naturally occurring anti-ageing products that can be effectively used through topical application.

  8. Scientific overview of hormone treatment used for rejuvenation.

    PubMed

    Morley, John E

    2013-06-01

    A search for a hormonal fountain of youth has been hotly pursued over the last century, predominately by those who wish to market hormones to a gullible public. There is little or no benefit of hormone replacement in persons who do not have a hormone deficiency. Overall, the present state of the art suggests that the findings have been disappointing. In persons who fail to get adequate sunlight, and therefore have low vitamin D levels, vitamin D replacement appears to have positive effects, including decreasing mortality. Testosterone in hypogonadal males has a number of positive effects such as improving libido and erectile capacity, increasing strength and bone mineral density, and perhaps having a small effect on cognition. These effects need to be balanced against long-term side effects, the evidence for which studies are lacking. There is little evidence to recommend DHEA, pregnenolone, growth hormone, ghrelin, or melatonin to older persons. Overall, exercise, adequate exposure to sunlight, and adequate dietary protein appear to have at least as positive an effect as any of the hormones being used to rejuvenate older persons. Copyright © 2013 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  9. 25th Birthday Cern- Restaurant

    SciTech Connect

    2006-05-05

    Cérémonie du 25ème anniversaire du Cern avec plusieurs orateurs et la présence de nombreux autorités cantonales et communales genevoises et personnalités, directeurs généraux, ministres, chercheurs.... Le conseiller féderal et chef du département des affaires étrangères de la confédération Monsieur Pierre Aubert prend la parole pour célébrer à la fois les résultats très remarquables de la coopération internationale en matière scientifique, mais aussi la volonté politique des états européens de mettre en commun leurs ressources pour faire oeuvre d'avenir. Un grand hommage est aussi donné aux deux directeurs disparus, les prof.Bakker et Gregory.

  10. Ceremony 25th birthday Cern

    ScienceCinema

    None

    2016-07-12

    Célébration du 25ème anniversaire du Cern (jour par jour) avec discours de L.Van Hove et J.B.Adams, des interludes musicals offerts par Mme Mey et ses collègues (au debut 1.mouvement du quatuor avec piano no 3 de L.van Beethoven) Les directeurs généraux procéderont à la remise du souvenir aux membres de personnel ayant 25 années de service dans l'organisation. Un témoignage de reconnaissance est auss fait à l'interprète Mme Zwerner

  11. 25th Birthday Cern- Amphi

    ScienceCinema

    None

    2016-07-12

    Cérémonie du 25ème anniversaire du Cern avec 2 orateurs: le Prof.Weisskopf parle de la signification et le rôle du Cern et le Prof.Casimir(?) fait un exposé sur les rélations entre la science pure et la science appliquée et la "big science" (science légère)

  12. 25th Birthday Cern- Restaurant

    ScienceCinema

    None

    2016-07-12

    Cérémonie du 25ème anniversaire du Cern avec plusieurs orateurs et la présence de nombreux autorités cantonales et communales genevoises et personnalités, directeurs généraux, ministres, chercheurs.... Le conseiller féderal et chef du département des affaires étrangères de la confédération Monsieur Pierre Aubert prend la parole pour célébrer à la fois les résultats très remarquables de la coopération internationale en matière scientifique, mais aussi la volonté politique des états européens de mettre en commun leurs ressources pour faire oeuvre d'avenir. Un grand hommage est aussi donné aux deux directeurs disparus, les prof.Bakker et Gregory.

  13. ESO 50th Anniversary Gala Dinner

    NASA Astrophysics Data System (ADS)

    Sirey, R.

    2012-12-01

    To formally mark the 50th anniversary of the signing of the ESO Convention, a gala dinner was held in the Munich Residenz. A brief report of the event is presented and the speeches are reproduced. The speakers were the President of the Council, Xavier Barcons; the German Minister for Education and Research, Prof. Dr Annette Schavan; the Bavarian State Minister for Science, Research and the Arts, Dr Wolfgang Heubisch; physics Nobel Laureate, Brian Schmidt; the current Director General, Tim de Zeeuw and the Chilean Minister of Foreign Affairs, Alfredo Moreno Charme.

  14. Investigation of the possibility of using waste cooking oil as a rejuvenating agent for aged bitumen.

    PubMed

    Zargar, Majid; Ahmadinia, Esmaeil; Asli, Hallizza; Karim, Mohamed Rehan

    2012-09-30

    The ageing of the bitumen during storage, mixing, transport and laying on the road, as well as in service life, are the most important problems presented by the use of bitumen in pavements. This paper investigates the possibility of using waste cooking oil (WCO), which is a waste material that pollutes landfills and rivers, as an alternative natural rejuvenating agent for aged bitumen to a condition that resembles the original bitumen. With this target, the physical and chemical properties of the original bitumen, aged bitumen and rejuvenated bitumen were measured and compared by the bitumen binder tests - softening point, penetration, Brookfield viscosity, dynamic shear rheometer and Fourier transform infrared spectroscopy. In addition, the behaviour of the WCO rejuvenated bitumen is investigated and compared with virgin bitumen after using the rolling thin film oven ageing process. In general, the results showed that using 3-4% of WCO the aged bitumen group 40/50 was rejuvenated to a condition that closely resembled the physical, rheological properties of the original bitumen (80/100), however, there was a difference in the tendency to ageing between the WCO rejuvenated bitumen and the virgin bitumen during mixing, transport and laying on the road.

  15. Proteomic profiling of proteins associated with the rejuvenation of Sequoia sempervirens (D. Don) Endl

    PubMed Central

    2010-01-01

    Background Restoration of rooting competence is important for rejuvenation in Sequoia sempervirens (D. Don) Endl and is achieved by repeatedly grafting Sequoia shoots after 16 and 30 years of cultivation in vitro. Results Mass spectrometry-based proteomic analysis revealed three proteins that differentially accumulated in different rejuvenation stages, including oxygen-evolving enhancer protein 2 (OEE2), glycine-rich RNA-binding protein (RNP), and a thaumatin-like protein. OEE2 was found to be phosphorylated and a phosphopeptide (YEDNFDGNSNVSVMVpTPpTDK) was identified. Specifically, the protein levels of OEE2 increased as a result of grafting and displayed a higher abundance in plants during the juvenile and rejuvenated stages. Additionally, SsOEE2 displayed the highest expression levels in Sequoia shoots during the juvenile stage and less expression during the adult stage. The expression levels also steadily increased during grafting. Conclusion Our results indicate a positive correlation between the gene and protein expression patterns of SsOEE2 and the rejuvenation process, suggesting that this gene is involved in the rejuvenation of Sequoia sempervirens. PMID:21143964

  16. Orbitofacial rejuvenation of temple hollowing with Perlane injectable filler.

    PubMed

    Ross, Jonathan J; Malhotra, Raman

    2010-01-01

    Temple hollowing with soft tissue volume loss is well recognized in HIV lipoatrophy. Similar changes occur as part of aging, with skeletalization of the orbital rim and clipping of the eyebrow tail. The authors report their initial experience treating temple volume loss and orbitofacial asymmetry with nonanimal stabilized hyaluronic acid (NASHA). This study was a retrospective, interventional case series with a patient satisfaction questionnaire and independent physician grading of results. Patients initially received approximately 1 mL of Perlane (Q-Med, Uppsala, Sweden; Medicis, Inc., Scottsdale, Arizona) injected into the superficial fascia of each temple. The filler was placed behind the frontozygomatic process to soften the bony contour of the lateral orbital rim. Outcome measures included satisfaction with injection procedure, fulfillment of expectations, satisfaction with appearance, change in self-confidence, the need for retreatment, and complications. Twenty patients were treated, for a total of 39 temples. Mean follow-up was nine months (range, four to 14 months). Patients were primarily female (90%), all were Caucasian, and their ages ranged from 20 to 60 years. Eighteen patients had age-related temple hollowing, one had dysthyroid volume loss, and one had hollowing due to orbitotemporal neurofibromatosis. The majority had 1-mL injections to each side (range, 0.3-3 mL). One patient received 3 mL to correct asymmetry. The procedure was well tolerated with ice pack cooling and no local anesthesia. Of 16 patients who replied to the questionnaire, 13 were very or moderately satisfied and requested repeat treatment, whereas three were only mildly satisfied or ambivalent. Side effects included transient mild or moderate discomfort, superficial vein prominence, and localized bruising. This series suggests the effective and safe application of Perlane in temple hollow rejuvenation and correction of asymmetry. It offers tolerability, high patient satisfaction

  17. Mitophagy-driven mitochondrial rejuvenation regulates stem cell fate

    PubMed Central

    Vazquez-Martin, Alejandro; Van den Haute, Chris; Cufí, Sílvia; Corominas-Faja, Bruna; Cuyàs, Elisabet; Lopez-Bonet, Eugeni; Rodriguez-Gallego, Esther; Fernández-Arroyo, Salvador; Joven, Jorge; Baekelandt, Veerle; Menendez, Javier A.

    2016-01-01

    Our understanding on how selective mitochondrial autophagy, or mitophagy, can sustain the archetypal properties of stem cells is incomplete. PTEN-induced putative kinase 1 (PINK1) plays a key role in the maintenance of mitochondrial morphology and function and in the selective degradation of damaged mitochondria by mitophagy. Here, using embryonic fibroblasts from PINK1 gene-knockout (KO) mice, we evaluated whether mitophagy is a causal mechanism for the control of cell-fate plasticity and maintenance of pluripotency. Loss of PINK1-dependent mitophagy was sufficient to dramatically decrease the speed and efficiency of induced pluripotent stem cell (iPSC) reprogramming. Mitophagy-deficient iPSC colonies, which were characterized by a mixture of mature and immature mitochondria, seemed unstable, with a strong tendency to spontaneously differentiate and form heterogeneous populations of cells. Although mitophagy-deficient iPSC colonies normally expressed pluripotent markers, functional monitoring of cellular bioenergetics revealed an attenuated glycolysis in mitophagy-deficient iPSC cells. Targeted metabolomics showed a notable alteration in numerous glycolysis- and TCA-related metabolites in mitophagy-deficient iPSC cells, including a significant decrease in the intracellular levels of α-ketoglutarate -a key suppressor of the differentiation path in stem cells. Mitophagy-deficient iPSC colonies exhibited a notably reduced teratoma-initiating capacity, but fully retained their pluripotency and multi-germ layer differentiation capacity in vivo. PINK1-dependent mitophagy pathway is an important mitochondrial switch that determines the efficiency and quality of somatic reprogramming. Mitophagy-driven mitochondrial rejuvenation might contribute to the ability of iPSCs to suppress differentiation by directing bioenergetic transition and metabolome remodeling traits. These findings provide new insights into how mitophagy might influence the stem cell decisions to retain

  18. Rejuvenation of metallic glasses by non-affine thermal strain.

    PubMed

    Ketov, S V; Sun, Y H; Nachum, S; Lu, Z; Checchi, A; Beraldin, A R; Bai, H Y; Wang, W H; Louzguine-Luzgin, D V; Carpenter, M A; Greer, A L

    2015-08-13

    When a spatially uniform temperature change is imposed on a solid with more than one phase, or on a polycrystal of a single, non-cubic phase (showing anisotropic expansion-contraction), the resulting thermal strain is inhomogeneous (non-affine). Thermal cycling induces internal stresses, leading to structural and property changes that are usually deleterious. Glasses are the solids that form on cooling a liquid if crystallization is avoided--they might be considered the ultimate, uniform solids, without the microstructural features and defects associated with polycrystals. Here we explore the effects of cryogenic thermal cycling on glasses, specifically metallic glasses. We show that, contrary to the null effect expected from uniformity, thermal cycling induces rejuvenation, reaching less relaxed states of higher energy. We interpret these findings in the context that the dynamics in liquids become heterogeneous on cooling towards the glass transition, and that there may be consequent heterogeneities in the resulting glasses. For example, the vibrational dynamics of glassy silica at long wavelengths are those of an elastic continuum, but at wavelengths less than approximately three nanometres the vibrational dynamics are similar to those of a polycrystal with anisotropic grains. Thermal cycling of metallic glasses is easily applied, and gives improvements in compressive plasticity. The fact that such effects can be achieved is attributed to intrinsic non-uniformity of the glass structure, giving a non-uniform coefficient of thermal expansion. While metallic glasses may be particularly suitable for thermal cycling, the non-affine nature of strains in glasses in general deserves further study, whether they are induced by applied stresses or by temperature change.

  19. Rejuvenating Hydrator: Restoring Epidermal Hyaluronic Acid Homeostasis With Instant Benefits.

    PubMed

    Narurkar, Vic A; Fabi, Sabrina G; Bucay, Vivian W; Tedaldi, Ruth; Downie, Jeanine B; Zeichner, Joshua A; Butterwick, Kimberly; Taub, Amy; Kadoya, Kuniko; Makino, Elizabeth T; Mehta, Rahul C; Vega, Virginia L

    2016-01-01

    Skin aging is a combination of multifactorial mechanisms that are not fully understood. Intrinsic and extrinsic factors modulate skin aging, activating distinctive processes that share similar molecular pathways. One of the main characteristics of youthful skin is its large capacity to retain water, and this decreases significantly as we age. A key molecule involved in maintaining skin hydration is hyaluronic acid (HA). Concentration of HA in the skin is determined by the complex balance between its synthesis, deposition, association with cellular structures, and degradation. HA bio-equivalency and bio-compatibility have been fundamental in keeping this macromolecule as the favorite of the skincare industry for decades. Scientific evidence now shows that topically applied HA is unable to penetrate the skin and is rapidly degraded on the skin surface. SkinMedica's HA5 Rejuvenating Hydrator (SkinMedica Inc., an Allergan company, Irvine, CA) promotes restoration of endogenous epidermal HA homeostasis and provides instant smoothing and hydration of the skin. These dual benefits are accomplished through the combination of 2 breakthrough technologies: 1) a unique blend of actives powered by SkinMedica proprietary flower-derived stem cell extract that restores the endogenous production of HA; and 2) a proprietary mix of 5 HA forms that plump the skin, decreasing the appearance of fine lines/wrinkles. Pre-clinical studies demonstrated that HA5 induces expression of key epidermal differentiation and barrier markers as well as epidermal HA synthases. A decrease expression of hyaluronidases was also observed upon HA5 application. Initial clinical studies showed that within 15 minutes of application, HA5 instantly improves the appearance of fine lines/wrinkles and skin hydration. Subjects that continue using HA5 (for 8 weeks) demonstrated significant improvements in fine lines/wrinkles, tactile roughness, and skin hydration. In summary, the blend of these 2 key technologies

  20. NASA Spitzer 12th Anniversary Space Calendar

    NASA Image and Video Library

    2015-08-20

    NASA Spitzer Space Telescope celebrated its 12th anniversary with a new digital calendar showcasing some of the mission most notable discoveries and popular cosmic eye candy. The digital calendar is online at http://www.jpl.nasa.gov/images/spitzer/20150820/Spitzer12thAnniversaryCalendar.pdf The calendar follows the life of the mission, with each month highlighting top infrared images and discoveries from successive years -- everything from a dying star resembling the eye of a monster to a star-studded, swirling galaxy. The final month includes a brand new image of the glittery star-making factory known as the Monkey Head nebula. Spitzer, which launched into space on August 25, 2003, from Cape Canaveral, Florida, is still going strong. It continues to use its ultra-sensitive infrared vision to probe asteroids, comets, exoplanets (planets outside our solar system) and some of the farthest known galaxies. Recently, Spitzer helped discover the closest known rocky exoplanet to us, named HD219134b, at 21 light-years away. In fact, Spitzer's exoplanet studies continue to surprise the astronomy community. The telescope wasn't originally designed to study exoplanets, but as luck -- and some creative engineering -- would have it, Spitzer has turned out to be a critical tool in the field, probing the climates and compositions of these exotic worlds. This pioneering work began in 2005, when Spitzer became the first telescope to detect light from an exoplanet. http://photojournal.jpl.nasa.gov/catalog/PIA19872

  1. Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast.

    PubMed

    Henderson, Kiersten A; Hughes, Adam L; Gottschling, Daniel E

    2014-09-04

    Replicative aging in yeast is asymmetric-mother cells age but their daughter cells are rejuvenated. Here we identify an asymmetry in pH between mother and daughter cells that underlies aging and rejuvenation. Cytosolic pH increases in aging mother cells, but is more acidic in daughter cells. This is due to the asymmetric distribution of the major regulator of cytosolic pH, the plasma membrane proton ATPase (Pma1). Pma1 accumulates in aging mother cells, but is largely absent from nascent daughter cells. We previously found that acidity of the vacuole declines in aging mother cells and limits lifespan, but that daughter cell vacuoles re-acidify. We find that Pma1 activity antagonizes mother cell vacuole acidity by reducing cytosolic protons. However, the inherent asymmetry of Pma1 increases cytosolic proton availability in daughter cells and facilitates vacuole re-acidification and rejuvenation.

  2. On the Effects of the Rejuvenation Treatment on Mechanical and Microstructural Properties of IN-738 Superalloy

    NASA Astrophysics Data System (ADS)

    Monti, Cosimo; Giorgetti, Alessandro; Tognarelli, Leonardo; Mastromatteo, Francesco

    2017-05-01

    The main scope of this paper is to show the effects of a specific rejuvenation treatment studied for IN-38 on both the microstructure and the mechanical properties of the creep-damaged superalloy and to compare the tests results with the virgin material and with the recovery obtained through the standard heat treatment. This work will show that this rejuvenation treatment is able to recover the microstructure of creep-damaged specimens and that the creep and tensile properties of the rejuvenated alloy are even better than the virgin material for the tests performed. Moreover, it will be shown that the standard heat treatment provided for IN-738 is not able to fully recover the microstructure and that the creep properties of the superalloy during the tests have been lower than the virgin material.

  3. Rejuvenation and memory in model spin glasses in three and four dimensions

    NASA Astrophysics Data System (ADS)

    Jiménez, S.; Martín-Mayor, V.; Pérez-Gaviro, S.

    2005-08-01

    We numerically study aging for the Edwards-Anderson model in three and four dimensions using different temperature-change protocols. In D=3 , time scales a thousand times larger than in previous work are reached with the Spin Update Engine (SUE) machine. Deviations from cumulative aging are observed in the nonmonotonic time behavior of the coherence length. Memory and rejuvenation effects are found in a temperature-cycle protocol, revealed by vanishing effective waiting times. Similar effects are reported for the D=3 site-diluted ferromagnetic Ising model (without chaos). However, rejuvenation is reduced if off-equilibrium corrections to the fluctuation-dissipation theorem are considered. Memory and rejuvenation are quantitatively describable in terms of the growth regime of the spin-glass coherence length.

  4. Descended Mouth Corner: An Ignored but Needed Feature of Facial Rejuvenation

    PubMed Central

    Berner, Juan Enrique; Castillo, Pablo; Rochefort, Günther; Loubies, Rodrigo

    2013-01-01

    For years, the gold standard in facial rejuvenation has been the face lift. However, exploring new, less complex procedures for achieving the same goal is currently drawing interest. Rejuvenation of the perioral area is a difficult task for plastic surgeons because of the minimal effect that face lift procedures have over this region and the lack of published material on the subject. In this article, the descended mouth corner anguloplasty technique is presented. It is a 20-minutes lift technique that can correct this typical feature of the ageing mouth. The authors have treated 71 patients using the technique with consistently good results, with just one requiring revision. They conclude that this procedure by itself and in combination with other small operations or even a full face lift can rejuvenate the ageing face. PMID:24286055

  5. Evaluation of Facial Volume Changes after Rejuvenation Surgery Using a 3-Dimensional Camera.

    PubMed

    Mailey, Brian; Baker, Jennifer L; Hosseini, Ava; Collins, Jessica; Suliman, Ahmed; Wallace, Anne M; Cohen, Steven R

    2016-04-01

    Surgical rejuvenation alters facial volume distribution to achieve more youthful aesthetic contours. These changes are routinely compared subjectively. The introduction of 3-dimensional (3D) stereophotogrammetry provides a novel method for measuring and comparing surgical results. We sought to quantify how specific facial areas are changed after rejuvenation surgery using the 3D camera. Patients undergoing facial rejuvenation were imaged preoperatively and postoperatively with 3D stereophotogrammetry. Images were registered using facial surface landmarks unaltered by surgery. Colorimetric 3D analysis depicting postoperative volume changes was performed utilizing the 3D imaging software and quantitative volume measurements were constructed. Nine patients who underwent combined facelift procedures and fat grafting were evaluated. Median time for postoperative imaging was 4.8 months. Positive changes in facial volume occurred in the forehead, temples, and cheeks (median changes, 0.9 mL ± 4.3 SD; 0.8 mL ± 0.47 SD; and 1.4 mL ± 1.6 SD, respectively). Negative changes in volume occurred in the nasolabial folds, marionette basins, and neck/submental regions (median changes, -1.0 mL ± 0.37 SD; -0.4 mL ± 0.9 SD; and -2.0 mL ± 4.3 SD, respectively). The technique of 3D stereophotogrammetry provides a tool for quantifying facial volume distribution after rejuvenation procedures. Areas of consistent volume increase include the forehead, temples, and cheeks; areas of negative volume change occur in the nasolabial folds, marionette basins, and submental/chin regions. This technology may be utilized to better understand the dynamic changes that occur with facial rejuvenation and quantify longevity of various rejuvenation techniques. 4 Diagnostic. © 2015 The American Society for Aesthetic Plastic Surgery, Inc. Reprints and permission: journals.permissions@oup.com.

  6. The reinforcement and healing of asphalt mastic mixtures by rejuvenator encapsulation in alginate compartmented fibres

    NASA Astrophysics Data System (ADS)

    Tabaković, A.; Post, W.; Cantero, D.; Copuroglu, O.; Garcia, S. J.; Schlangen, E.

    2016-08-01

    This paper explores the potential use of compartmented alginate fibres as a new method of incorporating rejuvenators into asphalt pavement mixtures. The compartmented fibres are employed to locally distribute the rejuvenator and to overcome the problems associated with spherical capsules and hollow fibres. The work presents proof of concept of the encapsulation process which involved embedding the fibres into the asphalt mastic mixture and the survival rate of fibres in the asphalt mixture. To prove the effectiveness of the alginate as a rejuvenator encapsulating material and to demonstrate its ability survive asphalt production process, the fibres containing the rejuvenator were prepared and subjected to thermogravimetric analysis and uniaxial tensile test. The test results demonstrated that fibres have suitable thermal and mechanical strength to survive the asphalt mixing and compaction process. The CT scan of an asphalt mortar mix containing fibres demonstrated that fibres are present in the mix in their full length, undamaged, providing confirmation that the fibres survived the asphalt production process. In order to investigate the fibres physiological properties and ability to release the rejuvenator into cracks in the asphalt mastic, the environmental scanning electron microscope and optical microscope analysis were employed. To prove its success as an asphalt healing system, compartmented alginate fibres containing rejuvenator were embedded in asphalt mastic mix. The three point bend tests were performed on the asphalt mastic test samples and the degree to which the samples began to self-heal in response was measured and quantified. The research findings indicate that alginate fibres present a promising new approach for the development of self-healing asphalt pavement systems.

  7. Skin rejuvenation using cosmetic products containing growth factors, cytokines, and matrikines: a review of the literature

    PubMed Central

    Aldag, Caroline; Nogueira Teixeira, Diana; Leventhal, Phillip S

    2016-01-01

    Skin aging is primarily due to alterations in the dermal extracellular matrix, especially a decrease in collagen I content, fragmentation of collagen fibrils, and accumulation of amorphous elastin material, also known as elastosis. Growth factors and cytokines are included in several cosmetic products intended for skin rejuvenation because of their ability to promote collagen synthesis. Matrikines and matrikine-like peptides offer the advantage of growth factor-like activities but better skin penetration due to their much smaller molecular size. In this review, we summarize the commercially available products containing growth factors, cytokines, and matrikines for which there is evidence that they promote skin rejuvenation. PMID:27877059

  8. The annual amount of lightning in just 20 minutes: the October 25th, 2015 super-cell thunderstorm over central Israel

    NASA Astrophysics Data System (ADS)

    Yair, Y.; Ziv, B.; Lynn, B. H.; Evgeni, K.

    2016-12-01

    An exceptionally rare Eastern Mediterranean super-cell thunderstorm occurred during the morning hours of October 25th 2015. The storm developed within the northern tip of a Red-Sea trough (extending from Sudan to the Southeastern Mediterranean Sea) off the Egyptian coastline near Alexandria and moved north-west, crossing the Israeli coast just north of Tel-Aviv at 0900 local time. Deep convective cells developed rapidly over the sea, with thunderclouds exhibiting cloud top temperatures colder than -70°C (18 km) and radar reflectivity cores > 65 dBz at 10 km. The storms were accompanied by intensive lightning activity, severe hail, downbursts, and intense rain. The super-cell subsided upon reaching the Jordan rift in eastern Israel. The super-cell caused 1 fatality, extensive flooding and agricultural damages. It also impacted the national electrical network with power outages lasting for 3 days in central Israel. More than 17,000 cloud-to-ground lightning strokes were registered by the lightning detection system of the Israeli Electrical Corporation, exceeding the annual average for the entire country. The average cloud-to-ground flash rates between 0940-0950 and 0950-1000 (local time) were greater than 436 and 430 strokes per minute respectively, exceeding the global record flash rates found in the Argentina-Paraguay border (Zipser et al., 2006). This was the most powerful thunderstorm ever observed in Israel since lightning detection became operational in 1997. Medium-range forecast models such as ECMWF and the GFS missed the timing and severity of this unusual storm. We will present a mesoscale and microphysical analysis of this event to better understand the origins and severity of this rare super-cell. WRF high-resolution simulations with lightning assimilation (Fierro et al., 2012; Lynn et al., 2015) coupled with the Dynamic Lightning Scheme (Lynn et al., 2012) will be used in order to evaluate the performance of the WRF for accurately nowcasting such events.

  9. Mechanism of the ML4.0 25th April 2016 Lacq (SW France) earthquake related to the gas extraction field

    NASA Astrophysics Data System (ADS)

    Aochi, Hideo; Delatre, Mickael; Burnol, André

    2017-04-01

    There were 11 earthquakes of magnitude larger than 3.8 in metropolitan France in 2016 according to the available catalogue EMSC. Among them, the ML4.0 25th April 2016 earthquake is suspected to be induced in gas exploitation field of Lacq, south-western France, close to the Pyreneans. The area is briefly covered by French national broad-band and acceleration networks and the data are available from ORFEUS/EIDA (European Integrated Data Achieves, http://www.orfeus-eu.org/data/eida/index.html ). In order to understand the mechanism of this earthquake and the state-of-art of the reservoir, it is essential to study the reliability of the focal depth and mechanism. We carry out a moment-tensor inversion using Genetic Algorithm. We select three broad-band stations at distance of about 50 km and applied a bandpass filter between 16 and 32 seconds. Green functions are calculated for the 1D layered structure. We fix the epicenter position determined by RéNaSS (Réseau National de Surveillance Sismique, http://www.renass.unistra.fr) and change the possible focal depths. The inversions show a good convergence to a solution of Mw3.8 indicating EW running normal faulting. This mechanism is consistent with the reservoir geometry of the gas field and may be interpreted as subsidence of the reservoir. However the obtained solution does not fit the nearest station, located a few hundred meters from the epicenter, probably due to lack of the precise epicenter position and/or local structure.

  10. Mathematics Education in the South Pacific. Proceedings of the Annual Conference of the Mathematics Education Research Group of Australasia Incorporated (25th, Auckland, New Zealand, July 7-10, 2002). Volume I [and] Volume II.

    ERIC Educational Resources Information Center

    Barton, Bill, Ed.; Irwin, Kathryn C., Ed.; Pfannkuch, Maxine, Ed.; Thomas, Michael O. J., Ed.

    This document contains the proceedings of the 25th annual conference of the Mathematics Education Research Group of Australia (MERGA) held at the University of Auckland, New Zealand. The focus of this meeting is mathematics education in the South Pacific. Presentations are centered around the topic of numeracy in primary or elementary school.…

  11. The Human Face of Technological Change. Theme Papers from the Silver Jubilee Conference of the Australian College of Education (25th, Australian Capital Territory, Canberra, May 5-9, 1984).

    ERIC Educational Resources Information Center

    Randell, Shirley, Ed.

    Papers presented at the 25th annual conference of the Australia College of Education addressed four major themes: The Brave New World of 1984; The Communications Revolution; Being Human in a Technological Age; and Implications of the Technological Society of Education. Papers in this volume include: (1) "The Challenge of Education in the…

  12. Mathematics Education in the South Pacific. Proceedings of the Annual Conference of the Mathematics Education Research Group of Australasia Incorporated (25th, Auckland, New Zealand, July 7-10, 2002). Volume I [and] Volume II.

    ERIC Educational Resources Information Center

    Barton, Bill, Ed.; Irwin, Kathryn C., Ed.; Pfannkuch, Maxine, Ed.; Thomas, Michael O. J., Ed.

    This document contains the proceedings of the 25th annual conference of the Mathematics Education Research Group of Australia (MERGA) held at the University of Auckland, New Zealand. The focus of this meeting is mathematics education in the South Pacific. Presentations are centered around the topic of numeracy in primary or elementary school.…

  13. Views of the Apollo 11 Twentieth Anniversary Black Tie reception

    NASA Image and Video Library

    1989-07-25

    View from the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Scene show NASA/JSC Director Aaron Cohen talking with NASA Administrator Richard H. Truly and his wife, Cody.

  14. Views of the Apollo 11 Twentieth Anniversary Black Tie reception

    NASA Technical Reports Server (NTRS)

    1989-01-01

    View from the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Scene show NASA/JSC Director Aaron Cohen talking with NASA Administrator Richard H. Truly and his wife, Cody.

  15. Color Panorama of Santa Maria Crater for Opportunity Anniversary

    NASA Image and Video Library

    2011-01-20

    NASA Mars Exploration Rover Opportunity is spending the seventh anniversary of its landing on Mars investigating a crater called Santa Maria, which has a diameter about the length of a football field. This scene looks eastward across the crater.

  16. Stereo Panorama of Santa Maria Crater for Opportunity Anniversary

    NASA Image and Video Library

    2011-01-20

    NASA Mars Exploration Rover Opportunity spent the seventh anniversary of its landing on Mars investigating a crater called Santa Maria, which has a diameter about the length of a football field. 3D glasses are necessary to view this image.

  17. Avation Safety Reporting System (ASRS) 40th Anniversary.

    NASA Image and Video Library

    2016-09-28

    Avation Safety Reporting System (ASRS) 40th Anniversary lunch and open house at the Sunnyvale office. Linda J. Connell, ASRS Program Director (left); Dr. John Lauber, Resident Scientist and early pioneer of the ASRS at Ames, 1972-1985 (Right).

  18. Views of the Apollo 11 Twentieth Anniversary Black Tie reception

    NASA Technical Reports Server (NTRS)

    1989-01-01

    View from the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Scene show NASA/JSC Director Aaron Cohen talking with NASA Administrator Richard H. Truly and his wife, Cody.

  19. Administrator Bolden Talks to Station Crew on 10th Anniversary

    NASA Image and Video Library

    NASA Administrator Charlie Bolden talks with the Expedition 25 crew on board the International Space Station on November 2, marking the tenth anniversary of continuous human presence on the orbitin...

  20. Avation Safety Reporting System (ASRS) 40th Anniversary

    NASA Image and Video Library

    2016-09-28

    Avation Safety Reporting System (ASRS) 40th Anniversary lunch and open house at the Sunnyvale office. Thomas A Edwards, Deputy Center Director NASA Ames (Left), presents a plaque On the anniversary of the aviation safety reporting system, this award is in recognition of 18 years of outstanding leadership as Program Director, resulting in strong program growth, expanded partnership and a widely recognized impact on National and Global transportation safety. Presented to Linda J. Connell, ASRS Program Director (Right)

  1. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong talks with a former Apollo team member during an anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  2. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong poses for a photograph with fans who attended the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  3. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong talks with a former Apollo team member during an anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  4. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong poses for a photograph with fans who attended the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon.

  5. Assessment of the aging level of rejuvenated hot mixed asphalt concrete pavements

    NASA Astrophysics Data System (ADS)

    McGovern, Megan; Buttlar, William G.; Reis, Henrique

    2016-04-01

    The efficacy of asphalt rejuvenator on restoring the properties of oxidatively aged asphalt was tested via a non-collinear ultrasonic subsurface wave mixing technique modified for field use. Longitudinal transducers were mounted on angle wedges to generate subsurface dilatational waves to allow for pavement evaluation when there is only access to one side. Because in the field the asphalt concrete (AC) pavement properties (i.e., ultrasonic velocities and attenuations) are unknown, a pre-determined fixed incident angle (based on the AC mixture type) was used, which allows for practical implementation in the field. Oxidative aged AC specimens were coated with rejuvenator (10% by weight of the binder) and left to dwell for varying amounts of time. Once the dwell time reached the desired amount, the specimen was immediately ultrasonically tested. The frequency ratio, f2/f1, at which the interaction took place and the normalized nonlinear wave generation parameter, β/β0, were recorded and compared against a reference plot. It was observed that the rejuvenator had the effect of restoring the nonlinear properties to those corresponding to a virgin sample after a sufficient amount of dwell time. The ability of the rejuvenator to fully penetrate and act on the binder was observed to be dependent on the porosity and aggregate structure, and thus varied for each specimen. As a result, some portions of the binder were restored to a greater extent than others. This non-uniform nature was captured via the nonlinear ultrasonic technique.

  6. The effectiveness of facial exercises for facial rejuvenation: a systematic review.

    PubMed

    Van Borsel, John; De Vos, Marie-Camille; Bastiaansen, Karen; Welvaert, Jaira; Lambert, Jo

    2014-01-01

    Although aesthetic correction of facial aging had long been the exclusive domain of plastic surgeons and dermatologists, alternative nonmedical approaches to facial rejuvenation are becoming more popular, such as facial acupuncture, facial acupressure, and facial exercises. However, the effectiveness of these alternative approaches is still a topic of debate. The authors review the evidence of the effectiveness of facial exercises for facial rejuvenation. A literature search was performed in Medline, Web of Science, Science Direct, SciELO, and LILACS databases for the terms facial rejuvenation, facial exercises, facial massage, face building, face yoga, (oro)facial (a)esthetics, (a)esthetic logopedics, and (a)esthetic speech therapy. Nine reports were identified from the search and were subject to further assessment. Although positive outcomes were achieved in all 9 studies, none of the studies used a control group and randomization process. They were single case reports, small case series, or studies with a single-group pretest-posttest design. Moreover, the effectiveness assessments in most of the studies were purely subjective, carried out by the authors and/or the patients themselves, without blinding. The evidence to date is insufficient to determine whether facial exercises are effective for facial rejuvenation. Evidence from large randomized controlled trials will be needed before conclusions can be drawn.

  7. Accumulation of free amino acids in marine diatom resting cells during rejuvenation

    NASA Astrophysics Data System (ADS)

    Chen, Changping; Li, Qingyu; Zhou, Qianqian; Sun, Lin; Zheng, Minhua; Gao, Yahui

    2014-01-01

    Many diatoms form resting stages under adverse growth conditions. These resting stages are known to rejuvenate once favorable conditions return, and resume vegetative growth after a certain lag period in which no divisions occurred, but what happens during this period remains unclear. Nitrogen uptake and the accumulation of free amino acids in Skeletonema marinoi resting cells during rejuvenation, but before cell division, were studied in laboratory cultures at different light intensities using the 15N-tracer technique. N uptake rate was higher for the rejuvenating cells at the higher light intensity. We hypothesized that the rapid and increasing N uptake at higher irradiance could enable S. marinoi to rebuild and reorganize its cell contents quickly and so dominate subsequent vegetative growth on the surficial sediment. Compared to the logarithmic growth phase and stationary phase, much higher concentrations of glycine (Gly) and histidine (His) were detected in resting cells, and His appeared to be a storage compound in S. marinoi resting cells. Compared to glutamine, glutamate had the higher 15N label enrichment under the light condition, showing a diel variation of N status during the lag period. The 15N labeled urea was detected at 36 h, compared to the urea cycle intermediates ornithine and citrulline at 30 h, indicating that urea was produced as an N reservoir due to the higher nitrogen uptake in the dark, and that the urea cycle was involved in S. marinoi resting cell rejuvenation.

  8. Optical timing observations of Swift J1753.5-0127 during its Feb 2017 rejuvenation

    NASA Astrophysics Data System (ADS)

    Gandhi, P.; Dhillon, V. S.; Marsh, T. R.; Green, M.; Ashley, R. P.; Altamirano, D.; Beri, A.; Shaw, A. W.; Tomsick, J. A.

    2017-02-01

    The black hole transient Swift J1753.5-0127 (hereafter, J1753) is currently showing rejuvenated accretion activity. X-ray, optical, and radio observations find that the source is returning to near pre-quiescent flux levels following a remarkably brief lull (ATel #10075, #10081, #10097, #10110, #10114).

  9. Pedagogic Rejuvenation in Teacher Education in India: Concept in NCFTE 2009

    ERIC Educational Resources Information Center

    Nath, Baiju K.; M.S, Sheeba

    2009-01-01

    The educational scenario in India country is now passing through an era of renovation and refinement. The school education as well as higher education is included in this rejuvenation, with least consideration to teacher education. Pedagogic changes gained momentum by the inception of nation wide schemes such as MLL, DPEP, SSA and the emerging…

  10. Functional vaginal rejuvenation with elastic silicone threads: a 4-year experience with 180 patients.

    PubMed

    Park, Tae Hwan; Park, Hye June; Whang, Kwi Whan

    2015-02-01

    Recently, there has been growing interest in female genital plastic surgery. To the authors' knowledge, no studies have adopted elastic silicone thread for vaginal rejuvenation. This study introduces clinical experience over 4 years with vaginal rejuvenation using elastic silicone thread to specifically assess the overall patient satisfaction (sexual function and correction of the vaginal width). It is hypothesised that this novel surgical method can improve sexual function. Between 2007-2011, 180 patients underwent vaginal rejuvenation using elastic silicone thread performed by the authors at a single institution. Patients with persistent feeling of a wide vagina and/or a decreased ability to reach orgasm were included. Patients were excluded from the study if they were unavailable for follow-up, or if they had been diagnosed with any gynecologic diseases. To measure the 15 degree of improvement with regard to sexual function, this study adopted the validated system; Female Sexual Function Index (FSFI). 92.8% (167/180) of the patients were satisfied with outcome with regard to feelings of correction of vaginal width. Vaginal rejuvenation using elastic silicone thread significantly improved postoperative outcomes, resulting in improved sexual function, with a focus on improving the FSFI score. This is especially prominent in FSFI orgasm subscore. However, a prospective multicentre study would be beneficial to provide patients with the best possible management.

  11. Rejuvenation of a mountain birch forest by an Epirrita autumnata (Lepidoptera: Geometridae) outbreak

    NASA Astrophysics Data System (ADS)

    Tenow, O.; Bylund, H.; Karlsson, P. S.; Hoogesteger, J.

    2004-03-01

    In 1955, the mountain birch forest in the Abisko valley of northern Sweden was defoliated by caterpillars of the moth Epirrita autumnata with death of stems of the polycormic trees as a result. Since then, some stands have recovered from surviving trees, producing new shoots while other stands became rejuvenated from basal sprouts. Usually, basal sprouting occurs after the death of whole trees or stems. In this case, extensive basal sprouting occurred in spite of only minor stem mortality. Two associated explanations to these differences were explored: (i) the abundant basal sprouting was caused by more top damage (and, hence, a reduced apical dominance) than in stands with less sprouting, (ii) this top damage was caused by a higher caterpillar density in the upper part of trees. Studies made during the outbreak and reported here confirm (i) and reject (ii) by showing that caterpillar densities were lower in the upper part of crowns than in the lower. The more extensive damage in the upper part of crowns may have several explanations. However, a specific sequence of events seemed to produce the rejuvenated stand. The sequence included a severe stress existing before the outbreak (as indicated by a decreased radial stem growth) which was increased by defoliations in two successive years. We, therefore, hypothesize that top dieback was caused by between - and within - stem competition for depleted carbohydrate resources at the expense of tree tops. The contributions of different types of sprouts to the rejuvenation and prerequisites for an outbreak to rejuvenate stands are discussed.

  12. Post-fire Gully Rejuvenation - Evidence of Process Thresholds Controlled by Vegetation Disturbance

    NASA Astrophysics Data System (ADS)

    Hyde, K.; Woods, S.

    2011-12-01

    High intensity rainfall may trigger gully rejuvenation on hillslopes recently disturbed by wildfire, leading to debris-laden flows which generally contribute the majority of sediment transported in post-fire erosion events. We investigated the extent to which the occurrence of gully rejuvenation can be predicted based upon burn severity, rainfall data and basin morphometric variables. Field surveys were conducted at six Northern Rockies sites to identify occurrence of gully rejuvenation in first order catchments and to map and characterize the location of gully heads. NEXRAD and rain gage data analysis coupled with field observations characterized rainfall intensity and extent. Building on previous work we quantified burn severity using the Vegetation Disturbance Index (VDI), a continuous metric based upon Burned Area Reflectance Classification (BARC) maps derived from satellite imagery using the dNBR algorithm. GIS analysis combined the VDI with morphometric factors expected to influence hillslope stability. Gully heads marked abrupt transition in channel form. Above gully heads, channels were shallow and U-shaped with gentle transition to the hillslope and fine root hairs intact. Angular edges marked deep gully head incisions which down-cut channel floors from 0.2-0.3 to 1.0 meter or more. Any remaining roots were coarse and the hillslope transition was sharp. Gully heads were located at variable distances below the master rill head of the catchment hollow. Distances were obviously greater where live canopy remained upslope. Gully head morphology strongly suggests flow force transition and exceedance of an erosion process threshold. The variable distance of the gully head below the hollow suggest upslope controls influencing initiation point, possibly degree and spatial pattern of burn severity. Binary logistic regression revealed stronger correlation between gully rejuvenation and VDI than morphometric variables. The statistical strength using the continuous

  13. Degradation and rejuvenation studies of AC electroluminescent ZnS:Cu,Cl phosphors

    NASA Astrophysics Data System (ADS)

    Stanley, Jacob; Jiang, Yu; Bridges, Frank; Carter, Sue A.; Ruhlen, Laurel

    2010-02-01

    We report detailed degradation and rejuvenation studies of AC electroluminescence (EL) of the phosphor ZnS:Cu,Cl, aiming to better understand the physical mechanisms that control EL emission. We find that the AC EL emission spectra vary considerably with the AC driving frequency but all spectra can be fit to a sum of four Gaussians. During degradation, although there is a large overall decrease in amplitude, the shape of the emission spectra measured at a given AC frequency does not change. Annealing the samples after they are significantly degraded can rejuvenate the phosphors with a maximum rejuvenation occurring (for fixed annealing times) near 180 °C. Further, these test cells can be degraded and rejuvenated multiple times. However studies at slightly higher annealing temperatures (240 °C) show significant thermal degradation and, perhaps more importantly, a change in the spectral shape; this likely indicates that two distinct mechanisms are then operative. In extended x-ray absorption fine structure (EXAFS) experiments we find that the CuS nanoprecipitates in the ZnS host (~75% of the Cu is in the CuS precipitates) do not change significantly after the 240 °C anneal; these experiments also provide a more detailed comparison of the local structure about Cu in pure CuS, and in ZnS:Cu,Cl. In addition, the EXAFS experiments also place an upper limit on the fraction of possible interstitial Cu sites, proposed as a blue emission center, at less than 10%. The combined experiments place strong constraints on the mechanisms for degradation and rejuvenation and suggest that EL degradation is most likely caused by either Cu or Cl diffusion under high E-fields, while thermal diffusion at slightly elevated temperatures without E-fields present, re-randomizes the (isolated) dopant distributions. Higher T anneals appear to damage the sharp tips on the precipitates.

  14. Rejuvenation Stage Volcanics at Laeo Kilauea, Kauai, Hawaii

    NASA Astrophysics Data System (ADS)

    Thordarson, T.; Garcia, M.; Wanless, D.; Tagami, T.; Sano, H.

    2005-12-01

    The Plio-Pleistocene Koloa volcanic series represents the rejuvenated volcanism on Kauai, one of the oldest main Hawaiian Islands. The Koloa series is made up of highly alkalic basalt and associated sedimentary rocks that rest unconformably on the shield-building Waimea Canyon volcanic series. Koloa vents are dispersed across the eastern two-thirds of the island and typically consist of scoria or lava cones that fed broad lava flow fields blanketing the marginal lowlands on the south, east and north side of the island. The northernmost subaerial Koloa vents are found at Laeo Kilauea on the north shore of the island. At Laeo Kilauea the volcanic succession is unusual in that it contains the only phreatomagmatic vent structures of the Koloa series. Here an ~2-km-long costal cliff face reveals a bedded phreatomagmatic tephra sequence that is >90-m-thick and represents the remnant of an a much large tuff cone (>2-km in diameter). The tuff cone sequence is characterized by decimeter to meters thick layers, where cross-bedded ash beds alternate with massive and poorly sorted lapilli tuff beds. The cross-bedded deposits were produced by dry and wet surges, whereas the poorly sorted beds represent fall deposits produced by sustained eruption column (i.e. continuous up-rush) or tephra jets (i.e. rooster-tail explosions). The juvenile clast population of the tephra consists of olivine-phyric foidite, but it also contains abundant wall-rock lithics, including fragments of reef-limestone. The base of the tuff cone outcrops at Mokolea point on the east side of the outcrop, where phreatomagmatic tephra rests directly on an older Koloa pahoehoe flow, a olivine- and mellelite-phyric foidite lava. The tephra sequence is cut by an ~1-m-thick olivine-bearing basanite dike, which acted as a feeder for the fountain-fed spatter and lava (up to 100-m-thick) that cap the phreatomagmatic tephra sequence. These units are separated by a 2-3 m thick soil horizon formed by weathering of the

  15. Multidisciplinary approach for the study of an Egyptian coffin (late 22nd/early 25th dynasty): Combining imaging and spectroscopic techniques

    NASA Astrophysics Data System (ADS)

    Bracci, S.; Caruso, O.; Galeotti, M.; Iannaccone, R.; Magrini, D.; Picchi, D.; Pinna, D.; Porcinai, S.

    2015-06-01

    This paper demonstrates that an educated methodology based on both non-invasive and micro invasive techniques in a two-step approach is a powerful tool to characterize the materials and stratigraphies of an Egyptian coffin, which was restored several times. This coffin, belonging to a certain Mesiset, is now located at the Museo Civico Archeologico of Bologna (inventory number MCABo EG 1963). Scholars attributed it to the late 22nd/early 25th dynasty by stylistic comparison. The first step of the diagnostic approach applied imaging techniques on the whole surface in order to select measurements spots and to unveil both original and restored areas. Images and close microscopic examination of the polychrome surface allowed selecting representative areas to be investigated in situ by portable spectroscopic techniques: X-ray Fluorescence (XRF), Fiber Optic Reflectance Spectroscopy (FORS) and Fourier Transform Infrared spectroscopy (FTIR). After the analysis of the results coming from the first step, very few selected samples were taken to clarify the stratigraphy of the polychrome layers. The first step, based on the combination of imaging and spectroscopic techniques in a totally non-invasive modality, is quite unique in the literature on Egyptian coffins and enabled us to reveal many differences in the ground layer's composition and to identify a remarkable number of pigments in the original and restored areas. This work offered also a chance to check the limitations of the non-invasive approach applied on a complex case, namely the right localization of different materials in the stratigraphy and the identification of binding media. Indeed, to dissolve any remaining doubts on superimposed layers belonging to different interventions, it was necessary to sample few micro-fragments in some selected areas and analyze them prepared as cross-sections. The original ground layer is made of calcite, while the restored areas show the presence of either a mixture of calcite

  16. Multidisciplinary approach for the study of an Egyptian coffin (late 22nd/early 25th dynasty): combining imaging and spectroscopic techniques.

    PubMed

    Bracci, S; Caruso, O; Galeotti, M; Iannaccone, R; Magrini, D; Picchi, D; Pinna, D; Porcinai, S

    2015-06-15

    This paper demonstrates that an educated methodology based on both non-invasive and micro invasive techniques in a two-step approach is a powerful tool to characterize the materials and stratigraphies of an Egyptian coffin, which was restored several times. This coffin, belonging to a certain Mesiset, is now located at the Museo Civico Archeologico of Bologna (inventory number MCABo EG 1963). Scholars attributed it to the late 22nd/early 25th dynasty by stylistic comparison. The first step of the diagnostic approach applied imaging techniques on the whole surface in order to select measurements spots and to unveil both original and restored areas. Images and close microscopic examination of the polychrome surface allowed selecting representative areas to be investigated in situ by portable spectroscopic techniques: X-ray Fluorescence (XRF), Fiber Optic Reflectance Spectroscopy (FORS) and Fourier Transform Infrared spectroscopy (FTIR). After the analysis of the results coming from the first step, very few selected samples were taken to clarify the stratigraphy of the polychrome layers. The first step, based on the combination of imaging and spectroscopic techniques in a totally non-invasive modality, is quite unique in the literature on Egyptian coffins and enabled us to reveal many differences in the ground layer's composition and to identify a remarkable number of pigments in the original and restored areas. This work offered also a chance to check the limitations of the non-invasive approach applied on a complex case, namely the right localization of different materials in the stratigraphy and the identification of binding media. Indeed, to dissolve any remaining doubts on superimposed layers belonging to different interventions, it was necessary to sample few micro-fragments in some selected areas and analyze them prepared as cross-sections. The original ground layer is made of calcite, while the restored areas show the presence of either a mixture of calcite

  17. PREFACE: 11th Asia-Pacific Conference on Plasma Science and Technology (APCPST-11) and 25th Symposium on Plasma Science for Materials (SPSM-25)

    NASA Astrophysics Data System (ADS)

    Watanabe, Takayuki; Kaneko, Toshio; Sekine, Makoto; Tanaka, Yasunori

    2013-06-01

    The 11th Asia-Pacific Conference on Plasma Science and Technology (APCPST-11) was held in Kyoto, Japan on 2-5 October 2012 with the 25th Symposium on Plasma Science for Materials (SPSM-25). SPSM has been held annually since 1988 under the sponsorship of The 153rd Committee on Plasma Materials Science, Japan Society for the Promotion of Science (JSPS). This symposium is one of the major activities of the Committee, which is organized by researchers in academia and industry for the purpose of advancing intersectional scientific information exchange and discussion of science and technology of plasma materials processing. APCPST and SPSM are jointly held biennially to survey the current status of low temperature and thermal plasma physics and chemistry for industrial applications. The whole area of plasma processing was covered from fundamentals to applications. Previous meetings were held in China, Japan, Korea, and Australia, attended by scientists from the Asia-Pacific and other countries. The joint conference was organized in plenary lectures, invited, contributed oral presentations and poster sessions. At this meeting, we had 386 participants from 10 countries and 398 presentations, including 26 invited presentations. This year, we arranged special topical sessions that covered green innovation, life innovation, and technical reports from industry. This conference seeks to bring the plasma community together and to create a forum for discussing the latest developments and issues, the challenges ahead in the field of plasma research and applications among engineers and scientists in Asia, the Pacific Rim, as well as Europe. This volume presents 44 papers that were selected via a strict peer-review process from full papers submitted for the proceedings of the conference. The topics range from the basic physics and chemistry of plasma processing to a broad variety of materials processing and environmental applications. This volume offers an overview of recent

  18. [Sanatorium "Arkhangelskoe" celebrates 80th anniversary].

    PubMed

    Kirillov, G N

    2013-10-01

    The article is dedicated to the 80th anniversary of sanatorium "Arkhangelskoe" celebrating in October 2013. Since October 16th, 1933 sanatorium is a military health resort, in 1934 sanatorium was named for "Sanatorium for command personnel of the Red Army". In 1935-1936 such prominent commaders as V.K. Blyukher, A.I. Egorov, A.I. Kork, M.N. Tukhachevskiy, G.M.Shtern, A.V. Khrulev, I.E. Yakir took rest in the sanatorium. Today organization of treatment and diagnostic services in the sanatorium meets modern requirements of medical science. Diagnostics includes the following methods: bicycle ergometry, medical treadmills, ECG and ABP monitoring, rheoencephalography, oscillography, ultrasonic diagnosis, monitoring of lipid and carbonaceous metabolism, blood coagulation and anticoagulation, enzymes, electrolytes and also bacteriologic, immunologic and serological tests. The following treatment methotds are used: climatotherapy, clinical nutrition, exercise therapy, spa treatment, balneo- and fangotherapy. Also methods of magnetotherapy, lasertherapy, ultrasonic therapy, hyperbaric oxygenation, phytotherapy and halotherapy are used.

  19. NASA Galaxy Mission Celebrates Sixth Anniversary

    NASA Image and Video Library

    2009-04-28

    NASA Galaxy Evolution Explorer Mission celebrates its sixth anniversary studying galaxies beyond our Milky Way through its sensitive ultraviolet telescope, the only such far-ultraviolet detector in space. The mission studies the shape, brightness, size and distance of distant galaxies across 10 billion years of cosmic history, giving scientists a wealth of data to help us better understand the origins of the universe. One such object is pictured here, the galaxy NGC598, more commonly known as M33. The image shows a map of the recent star formation history of M33. The bright blue and white areas are where star formation has been extremely active over the past few million years. The patches of yellow and gold are regions where star formation was more active 100 million years ago. In addition, the ultraviolet image shows the most massive young stars in M33. These stars burn their large supply of hydrogen fuel quickly, burning hot and bright while emitting most of their energy at ultraviolet wavelengths. Compared with low-mass stars like our sun, which live for billions of years, these massive stars never reach old age, having a lifespan as short as a few million years. http://photojournal.jpl.nasa.gov/catalog/PIA12000

  20. PREFACE: Proceedings of the 25th International Conference on Low Temperature Physics (LT25) (Amsterdam, The Netherlands, 6-13 August 2008) Proceedings of the 25th International Conference on Low Temperature Physics (LT25) (Amsterdam, The Netherlands, 6-13 August 2008)

    NASA Astrophysics Data System (ADS)

    Kes, Peter; Jochemsen, Reijer

    2009-04-01

    This issue forms part I of the Proceedings of the 25th International Conference on Low Temperature Physics (LT25) (Amsterdam, The Netherlands, 67-13 August 2008). The majority of the special invited lectures, such as the London prize lectures, the international union of pure and applied physics (IUPAP) young scientist award lectures, the plenary, half-plenary and public lectures, and the historical lectures presented at the LT25 conference, are included. The papers relating to the oral and poster presentations will appear in part II of the proceedings in a dedicated open access issue of Journal of Physics: Conference Series (2009 J. Phys.: Conf. Ser. 150). In addition to the organizer's report and a summary of the new developments in low temperature physics, which can also be found in this issue, part II provides useful information about LT25, such as an overview of committees, sponsors, exhibitors, and some conference statistics. To ensure the high publication standard mandated by Journal of Physics: Condensed Matter and Journal of Physics: Conference Series every paper was reviewed by at least one referee before it was accepted for publication. The editors are indebted to many colleagues for invaluable assistance in the preparation and review of 900 papers appearing in both parts I and II of these proceedings. In particular, we would like to thank Carlo Beenakker, Jeroen van den Brink, Hans Brom, Jos de Jongh, Horst Rogalla, Fons de Waele, and Jan Zaanen.

  1. 46 CFR 30.10-2a - Anniversary date-TB/ALL.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Anniversary date-TB/ALL. 30.10-2a Section 30.10-2a Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-2a Anniversary date—TB/ALL. The term anniversary date means the day and the month of each year,...

  2. 46 CFR 30.10-2a - Anniversary date-TB/ALL.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 1 2011-10-01 2011-10-01 false Anniversary date-TB/ALL. 30.10-2a Section 30.10-2a Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY TANK VESSELS GENERAL PROVISIONS Definitions § 30.10-2a Anniversary date—TB/ALL. The term anniversary date means the day and the month of each year,...

  3. The unexpected outcomes of anti-aging, rejuvenation, and life extension studies: an origin of modern therapies.

    PubMed

    Stambler, Ilia

    2014-06-01

    The search for life-extending interventions has been often perceived as a purely academic pursuit, or as an unorthodox medical enterprise, with little or no practical outcome. Yet, in fact, these studies, explicitly aiming to prolong human life, often constituted a formidable, though hardly ever acknowledged, motivation for biomedical research and discovery. At least several modern biomedical fields have originated directly from rejuvenation and life extension research: (1) Hormone replacement therapy was born in Charles-Edouard Brown-Séquard's rejuvenation experiments with animal gland extracts (1889). (2) Probiotic diets originated in Elie Metchnikoff's conception of radically prolonged "orthobiosis" (c. 1900). (3) The development of clinical endocrinology owed much to Eugen Steinach's "endocrine rejuvenation" operations (c. 1910s-1920s). (4) Tissue transplantations in humans (allografts and xenografts) were first widely performed in Serge Voronoff's "rejuvenation by grafting" experiments (c. 1910s-1920s). (5) Tissue engineering was pioneered during Alexis Carrel's work on cell and tissue immortalization (c. 1900-1920). (6) Cell therapy (and particularly human embryonic cell therapy) was first widely conducted by Paul Niehans for the purposes of rejuvenation as early as the 1930s. Thus, the pursuit of life extension and rejuvenation has constituted an inseparable and crucial element in the history of biomedicine. Notably, the common principle of these studies was the proactive maintenance of stable, long-term homeostasis of the entire organism.

  4. ["Skin rejuvenation" by non-ablative laser and light systems. Literature research and overview].

    PubMed

    Grema, H; Raulin, C; Greve, B

    2002-06-01

    Currently, ablative laser therapy (with CO2/Er:YAG lasers) and deep chemical peeling are effective and promising methods of skin rejuvenation. The induction of collagen synthesis was observed after peelings with trichloroacetic acid or phenol as well as after treatments with the CO2 laser. In past years, the undesirable side effects and risks of these methods have led to intensified research in the fields of non-ablative facial rejuvenation and subsurfacing by means of ablative laser systems and intense pulsed light systems. The objective is to achieve selective, heat-induced denaturalisation of dermal collagen that leads to subsequent reactive synthesis but does not damage the epidermis. Recently, the results of numerous clinical and histological studies have indicated that these new technologies are successful. After critical review and assessment of current literature, we can say that in terms of their efficacy, non-ablative methods are not a comparable alternative to ablative skin resurfacing.

  5. Long-chain polynucleotide filler for skin rejuvenation: efficacy and complications in five patients.

    PubMed

    Park, Kui Young; Seok, Joon; Rho, Nark Kyoung; Kim, Beom Joon; Kim, Myeung Nam

    2016-01-01

    Aging well has become the new target of preventative medicine, and aesthetic dermatology can contribute to this request. The polynucleotide (PN) containing products not only fill the space, but improve tissue regeneration, resulting in more natural tissue regeneration. Five Korean women received four times injections of long-chain PN filler in two-week intervals for skin rejuvenation. About 0.05 mL of material was injected in 40 points of one-side cheek. The pore and skin thickness were markedly improved in the patients in their 30s, whereas skin tone, melanin, wrinkles, and sagging were noticeably improved for patients in their 40s. There are no serious side effects. In conclusion, intradermal long-chain PN filler injection seems to be an effective and safe treatment for skin rejuvenation.

  6. Role of fault rejuvenation in hydrocarbon accumulation and structural evolution of Reconcavo basin, northeastern Brazil

    SciTech Connect

    Cohen, C.R.

    1985-01-01

    From a geometric analysis of the fault pattern in the Reconcavo basin, Brazil, supported by a reinterpretation of the early opening history of the South Atlantic Ocean, it is inferred that the basin formed as a result of Valanginian (Early Cretaceous) motion on a major N40/sup 0/E-striking left-lateral transform fault located offshore between Salvador and Recife. Left-lateral movement along the inferred transform created three fault sets. Geohistory curves for Early Cretaceous units in the Reconcavo basin indicate that the syn-tectonic Valanginian shales of the lacustrine Candeias Formation began to generate hydrocarbons during the earliest subsequent deposition of the Ilhas Formation (.Hauterivian). Rejuvenation as normal faults of earlier formed strikeslip and normal faults occurred in the latest Aptian. Rejuvenated faults tapped earlier filled Sergi Formation reservoirs, which then leaked earlier reservoired hydrocarbons up these fault planes into higher reservoirs in the Ilhas and Sao Sebastiao Formations.

  7. A facile way to rejuvenate Ag3PO4 as a recyclable highly efficient photocatalyst.

    PubMed

    Wang, Hua; Bai, Yusong; Yang, Jutong; Lang, Xiufeng; Li, Jinghong; Guo, Lin

    2012-04-27

    Recycling awarded the silver: Ag(3)PO(4), a highly efficient photocatalyst, decomposes to the weak photocatalyst Ag during consecutive photocatalytic cycles. A facile and very mild wet chemical oxidation method was proposed, which involves the cooperation of H(2)O(2) with Na(2)HPO(4), to rejuvenate Ag(3)PO(4) from Ag as a recyclable highly efficient photocatalyst. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Facial rejuvenation for middle-aged women: a combined approach with minimally invasive procedures

    PubMed Central

    Goldman, Alberto; Wollina, Uwe

    2010-01-01

    Facial rejuvenation is a significant process involved in restoring youthfulness. The introduction of less invasive procedures has increased acceptance of such procedures. Often a combination of different techniques allows individualized treatment with optimal outcomes. Furthermore, this leads to a natural look without a significant downtime. We report herein the use of such a combined approach in middle-aged women with particular emphasis on botulinum toxin type A, dermal fillers, and chemical peels. PMID:20924438

  9. Endoscopic treatment of salivary gland injuries due to facial rejuvenation procedures.

    PubMed

    Nahlieli, Oded; Abramson, Alex; Shacham, Rachel; Puterman, Max B; Baruchin, Abraham M

    2008-05-01

    The purpose of this article is to describe innovative surgical techniques for treatment of salivary gland injuries caused by facial rejuvenation procedures. Between 2001 and 2007, a total of 14 patients, all females ages 46 to 70 who suffered from salivary gland injuries caused by facial rejuvenation procedures, were treated, primarily by an endoscopic-guided technique that involved location of the injury and endoscopic repair. There were four types of postsurgical injuries of the salivary glands that were caused by operations for facial rejuvenation: 1) compression of salivary ducts with temporary swelling (n = 1); 2) laceration of the capsule of the salivary gland (n = 3); 3) stretching and compression of the ducts with penetration of the capsule of the duct leading to sialocele and long-term swelling (types 1 and 2 combined) (n = 5); and 4) complete cut or penetration of the main salivary duct or of one of its main branches resulting in sialocele (n = 5). The endoscopic technique treatment was successful in all cases. The main reasons for salivary gland injuries due to facial rejuvenation procedures in our patients were: poor anatomical identification of the border between the superficial muscular aponeurotic system (SMAS) and the parotid capsule; penetration of the salivary gland capsule by blunt or sharp dissection; unnecessary use of sharp-tip scissors; and a tear of the salivary duct by hooks during a face-lift procedure. Plastic surgeons should be aware of these complications and try to improve their techniques accordingly. To avoid atrophy of the salivary gland, once the diagnosis it made, it is advisable to send the patient to a maxillofacial or ENT surgeon skilled in endoscopy.

  10. Thread-lift for facial rejuvenation: assessment of long-term results.

    PubMed

    Abraham, Rima F; DeFatta, Robert J; Williams, Edwin F

    2009-01-01

    To evaluate the long-term success of the thread-lift procedure for facial rejuvenation. Thirty-three patients underwent a thread-lift procedure alone or in combination with other facial rejuvenation procedures to the brow, midface, jowl, and neck. Ten patients underwent thread-lifts only, and 23 had thread-lifts with other procedures. Ten additional patients having had non-thread-lift rejuvenation procedures, including lipotransfer, chemical peels, and rhytidectomies, were randomly designated as controls. The mean follow-up period was 21 months (range, 12-31 months). Photodocumentation was obtained at each visit. Long-term aesthetic results were evaluated by 4 independent, blinded, and board-certified facial plastic surgeons. Each result was graded on a scale of 0 to 3, with 0 indicating no change; 1, minimal improvement; 2, moderate improvement; and 3, considerable improvement. The population was divided into 3 groups for comparison. Two-tailed t test (P = .05) was used for statistical analysis of aesthetic outcomes. Although aesthetic improvement was noted in all groups at 1 month, measurable results persisted to the end of the study for all but the group that underwent the thread-lift procedure only. Aesthetic improvement scores of the non-thread-lift control group were better than the group that underwent thread-lift only. Similarly, when the thread-lift was combined with other procedures, scores were better than when thread-lift was used alone. Statistical significance was demonstrated in both of these comparisons (P < .01). The thread-lift provides only limited short-term improvement that may be largely attributed to postprocedural edema and inflammation. Our results objectively demonstrate the poor long-term sustainability of the thread-lift procedure. Given these findings, as well as the measurable risk of adverse events and patient discomfort, we cannot justify further use of this procedure for facial rejuvenation.

  11. New lift: the art of facial rejuvenation with minimal incisions rhytidectomy.

    PubMed

    Tarallo, M; Toscani, M; Di Taranto, G; Sorvillo, V; Fino, P

    2016-11-01

    The new lift is a procedure for facial rejuvenation with minimal incision, giving the patient a significant improvement of mid face and neck, with limited dissection and minimal scars. A further "One-stitch" of anchorage to the deep temporal fascia is required to hold tissues. By a minimal surgical access, we get a suitable cheek lift with the improvement of nose-labial folds, mandibular edge and neck contour. Between February 2009 and June 2012, 32 patients underwent facial rejuvenation surgery called new lift at a mean age of 46 years (range 35-55 years). Seven of the patients had a previous facelift. 12 out of 32 patients (37.5%) had concomitant eyelid surgery and 4 (12.5%) neck contouring procedure. The technique we used is a safe and effective procedure with a high satisfaction rate; 28 patients (89%) were very satisfied with their result at 24-months follow-up. The surgical outcome was evaluated according to the analysis of photographs obtained before and after surgery and the analysis of pre- and postoperative measurements. Aesthetic results were evaluated also by patients themselves who indicated a high satisfaction rate at three months post-surgery questionary and by a surgeon not involved in the study using VAS (1-10) before and three months after surgery. Acquired data on the aesthetic result were statistically evaluated using Student t-test. This is a study aimed at assessing the effectiveness of the new-lift technique for facial rejuvenation. Based on the results of our study, the new-lift is a very effective surgery for rejuvenation of the face with mild to moderate aging. All patients healed uneventfully without any major postoperative problems. This technique responds to an increasing demand from a wide range of patients for less invasive, less expensive operations with faster healing time and fewer potential complications.

  12. Versatility of erbium YAG laser: from fractional skin rejuvenation to full-field skin resurfacing.

    PubMed

    Holcomb, J David

    2011-05-01

    For the laser surgeon, the Er-YAG laser is an invaluable tool that delivers unsurpassed ablation efficiency, and with appropriate functionality (quasi long-pulse feature) provides sufficient tissue coagulation to remodel deep rhytids. As such, the 2940-nm wavelength is well suited for routine laser skin rejuvenation in full-field, fractional, and point-beam modes with additional benefits, including applicability to diverse skin types, short healing times, and a low likelihood of energy-related complications.

  13. Thermal models beneath Kamchatka and the Pacific Plate rejuvenation from a mantle plume impact

    NASA Astrophysics Data System (ADS)

    Manea, V. C.; Manea, M.

    The Northwest Pacific area, comprising the Kamchatka peninsula, is a distinctive area where a series of on going geodynamical processes like: plate rejuvenation from a mantle plume impact, slab detachment, slab edge melting and exotic volcanism, take place. With the help of finite element modeling we infer the thermal structure across Kamchatka in a series of 2D profiles normal to the trench. We chose the location at these profiles based on seismicity, geochemical variation and offshore heat flow measurements. Assuming that the transition from brittle to ductile behavior inside the subducting slab corresponds to the 650°C isotherm, our thermal models predict a good fit with maximum depth of seismicity (˜500 km) for southern Kamchatka only if the exothermic olivine-spinel phase transition is introduced. In the central part of Kamchatka, a good fit is obtained if the hot mantle plume, located just beneath Meiji Guyot seamount, thermally rejuvenates the subducting Pacific plate. Further to the north, the seismicity shallows more (200-100 km) and slab rejuvenation alone cannot provide a thermal structure with a good fit with seismically active subducting slab. A good explanation for such shallow seismicity might be the slab detachment due to cessation of subduction just north of Kamchatka-Aleutians junction. The thermal structure beneath the northernmost active volcano in Kamchatka, Scheveluch, which exhibits a strong adakitic signature, shows that slab edge exposure to the hotter asthenosphere creates the favorable conditions for oceanic crust melting at ˜70 km depth, just beneath Scheveluch. Our numerical models show that plate rejuvenation from a mantle plume, slab edge exposure to hot upper mantle and probably slab detachment play an essential role in subduction slabs thermal structure, seismicity down-dip extension and geochemical variations of lavas in Kamchatka.

  14. European expert recommendations on the use of injectable poly-L-lactic acid for facial rejuvenation.

    PubMed

    Alessio, Redaelli; Rzany, Berthold; Eve, Linda; Grangier, Yann; Herranz, Pedro; Olivier-Masveyraud, Frédérique; Vleggaar, Danny

    2014-09-01

    Over the last few years, there have been a number of important changes in how we appreciate and understand the aging face. Volume loss is now recognized as a major component of facial aging. Treatment options that replace lost volume are increasingly used for recontouring and rejuvenation of the aging face. In this review we present and discuss the European Expert Group recommendations on the ideal use of the unique collagen stimulator, poly-L-lactic acid (PLLA, Sculptra®, Sinclair Pharmaceuticals) for facial rejuvenation lasting up to 25 months. Optimal results are achieved based on a detailed knowledge of facial anatomy, correct treatment procedure, specifically the right dilution, the correct injection technique, as well as appropriate patient aftercare. PLLA is an effective and safe collagen stimulator that treats the whole face. PLLA is simple to use, provides the foundation for facial rejuvenation, is easy to combine with other treatments, and gives long-lasting effects with a high level of patient satisfaction.

  15. De Novo Assembly of the Transcriptome of Turritopsis, a Jellyfish that Repeatedly Rejuvenates.

    PubMed

    Hasegawa, Yoshinori; Watanabe, Takashi; Takazawa, Masaki; Ohara, Osamu; Kubota, Shin

    2016-08-01

    In most animals, aging is an irreversible process; however the species Turritopsis sp. has been observed to undergo a rejuvenation process as many as 14 times. In the present study, we used multiplexed RNA libraries to obtain the transcriptome from four developmental stages (St) of Turritopsis sp., including (I) immature medusa, (II) dumpling, (III) dumpling with a short stolon, and (IV) polyp, which had recently rejuvenated. A total of 4.02 billion paired-end reads were assembled de novo, yielding 90,327 contigs. Our analyses revealed that significant blast hits were recovered for 74% of the assembled contigs, and 19% were successfully annotated with gene ontology (GO) terms. A BLAST search demonstrated that 32% of the contigs were most similar to Hydra vulgarissequences. Raw reads from each sample were mapped against the contigs to find St-specific genes. This represents the first comprehensive set of de novo transcriptome data for this species, which may provide clues toward a better understanding of cyclical rejuvenation in multicellular animals.

  16. The aging face in patients of color: minimally invasive surgical facial rejuvenation-a targeted approach.

    PubMed

    Harris, Monte O

    2004-01-01

    We are in the midst of exciting times from a demographic standpoint as the population of darker-skinned people grows exponentially in the United States. Although there is a growing demand for facial cosmetic procedures amongst people of color, the total number of individuals undergoing surgical facial rejuvenation is dwarfed by the current Caucasian market. In order to provide optimal options for facial rejuvenation, cosmetic surgeons must have an underlying appreciation for the dynamic interplay among ethnicity, facial morphology, and the progression of aging. The purpose of the present article is to outline the minimally invasive surgical options for facial rejuvenation best suited for the patient of color. Although the population of individuals with darker-pigmented skin is quite vast, the present paper will focus on individuals of African descent, with whom the author has the most experience. Preferred surgical techniques include blepharoplasty, autologous facial fat transplantation, percutaneous cheek lift, and submental liposuction. Cutaneous surgeons familiar with soft-tissue surgery and facial anatomy should feel comfortable performing these techniques.

  17. Development of Facial Rejuvenation Procedures: Thirty Years of Clinical Experience with Face Lifts

    PubMed Central

    Kim, Byung Jun; Choi, Jun Ho

    2015-01-01

    Facial rejuvenation procedures can be roughly divided into face lift surgery and nonoperative, less invasive procedures, such as fat grafts, fillers, botulinum toxin injections, thread lifts, or laserbrasion. Face lift surgery or rhytidectomy is the procedure most directly associated with rejuvenation, due to its fundamental ability to restore the anatomical changes caused by aging. Various methods of face lift surgery have been developed over the last hundred years, thanks to advances in the understanding of facial anatomy and the mechanisms of aging, as well as the dedication of innovative surgeons. However, no generally applicable standard method exists, because the condition of each patient is different, and each operative method has advantages and disadvantages. Specific characteristics of the skin of Asians and their skeletal anatomy should be considered when determining the operative method to be used on Asian patients. Plastic surgeons should improve their ability to analyze the original aesthetic properties and problem areas of each patient, drawing on scientific knowledge about the aging process, and they should develop the skills necessary to perform various rejuvenative techniques. In the present article, we reviewed various face lift procedures and the current methods of modified double plane face lift, based on our clinical experience of over 30 years. PMID:26430622

  18. Seismological constraints on the crustal structures generated by continental rejuvenation in northeastern China.

    PubMed

    Zheng, Tian-Yu; He, Yu-Mei; Yang, Jin-Hui; Zhao, Liang

    2015-10-07

    Crustal rejuvenation is a key process that has shaped the characteristics of current continental structures and components in tectonic active continental regions. Geological and geochemical observations have provided insights into crustal rejuvenation, although the crustal structural fabrics have not been well constrained. Here, we present a seismic image across the North China Craton (NCC) and Central Asian Orogenic Belt (CAOB) using a velocity structure imaging technique for receiver functions from a dense array. The crustal evolution of the eastern NCC was delineated during the Mesozoic by a dominant low seismic wave velocity with velocity inversion, a relatively shallow Moho discontinuity, and a Moho offset beneath the Tanlu Fault Zone. The imaged structures and geochemical evidence, including changes in the components and ages of continental crusts and significant continental crustal growth during the Mesozoic, provide insight into the rejuvenation processes of the evolving crust in the eastern NCC caused by structural, magmatic and metamorphic processes in an extensional setting. The fossil structural fabric of the convergent boundary in the eastern CAOB indicates that the back-arc action of the Paleo-Pacific Plate subduction did not reach the hinterland of Asia.

  19. Seismological constraints on the crustal structures generated by continental rejuvenation in northeastern China

    PubMed Central

    Zheng, Tian-Yu; He, Yu-Mei; Yang, Jin-Hui; Zhao, Liang

    2015-01-01

    Crustal rejuvenation is a key process that has shaped the characteristics of current continental structures and components in tectonic active continental regions. Geological and geochemical observations have provided insights into crustal rejuvenation, although the crustal structural fabrics have not been well constrained. Here, we present a seismic image across the North China Craton (NCC) and Central Asian Orogenic Belt (CAOB) using a velocity structure imaging technique for receiver functions from a dense array. The crustal evolution of the eastern NCC was delineated during the Mesozoic by a dominant low seismic wave velocity with velocity inversion, a relatively shallow Moho discontinuity, and a Moho offset beneath the Tanlu Fault Zone. The imaged structures and geochemical evidence, including changes in the components and ages of continental crusts and significant continental crustal growth during the Mesozoic, provide insight into the rejuvenation processes of the evolving crust in the eastern NCC caused by structural, magmatic and metamorphic processes in an extensional setting. The fossil structural fabric of the convergent boundary in the eastern CAOB indicates that the back-arc action of the Paleo-Pacific Plate subduction did not reach the hinterland of Asia. PMID:26443323

  20. Skin rejuvenation by microneedle fractional radiofrequency treatment in Asian skin; clinical and histological analysis.

    PubMed

    Seo, Kyu Young; Yoon, Moon Soo; Kim, Dong Hyun; Lee, Hee Jung

    2012-10-01

    For skin rejuvenation, microneedle fractional radiofrequency (RF) is a recently developed minimally invasive method for delivering RF energy directly into the skin using microneedle. We evaluated efficacy and safety of microneedle fractional RF for skin rejuvenation in Asian skin and also conducted immunohistochemical analysis before and after treatment. Twenty-five females (mean age 54.2, Fitzpatrick skin phototypes III-IV) received three consecutive fractional RF treatment at 4-week intervals. Outcome assessments included standardized photography, physician's global assessment, patient's satisfaction scores, objective biophysical measurements, and histologic analysis including immunohistochemical staining. All patients showed clinical improvement on physician's global assessment and patient's satisfaction scores. Among objective biophysical measurements, improvement in hydration and skin roughness was noticed. Histologic examination revealed marked increase in dermal thickness, dermal collagen content and dermal fibrillin content. Side effects were minimal. The limitations are the small number of patients and lack of long-term follow-up. Microneedle fractional RF is a safe and effective skin rejuvenation method in Asians. Copyright © 2012 Wiley Periodicals, Inc.

  1. Theory of aging, rejuvenation, and the nonequilibrium steady state in deformed polymer glasses.

    PubMed

    Chen, Kang; Schweizer, Kenneth S

    2010-10-01

    The nonlinear Langevin equation theory of segmental relaxation, elasticity, and mechanical response of polymer glasses is extended to describe the coupled effects of physical aging, mechanical rejuvenation, and thermal history. The key structural variable is the amplitude of density fluctuations, and segmental dynamics proceeds via stress-modified activated barrier hopping on a dynamic free-energy profile. Mechanically generated disorder (rejuvenation) is quantified by a dissipative work argument and increases the amplitude of density fluctuations, thereby speeding up relaxation beyond that induced by the landscape tilting mechanism. The theory makes testable predictions for the time evolution and nonequilibrium steady state of the alpha relaxation time, density fluctuation amplitude, elastic modulus, and other properties. Model calculations reveal a rich dependence of these quantities on preaging time, applied stress, and temperature that reflects the highly nonlinear competition between physical aging and mechanical disordering. Thermal history is "erased" in the long-time limit, although the nonequilibrium steady state is not the literal "fully rejuvenated" freshly quenched glass. The present work provides the conceptual foundation for a quantitative treatment of the nonlinear mechanical response of polymer glasses under a variety of deformation protocols.

  2. Perioral soft-tissue rejuvenation techniques to enhance esthetic restorative dentistry.

    PubMed

    Niamtu, Joseph

    2003-11-01

    Every practitioner has the obligation to offer his or her patients the latest advances in their profession. Dentistry has made a shift over the past 50 years from caries restoration and prosthetic replacement to preventative and esthetic rejuvenation. Related dental specialties have also blossomed with new procedures and an expanded scope of practice. This shift has also included more comprehensive care and treatment of the oral and maxillofacial region. Modern esthetic dentists realize the facial soft tissues serve as a frame for their restorative artwork. Contemporary oral and maxillofacial surgery includes cosmetic facial surgery. Procedures for such surgery are taught in oral and maxillofacial surgery residency programs, are part of the oral and maxillofacial surgery board exams, and are covered by oral and maxillofacial surgery malpractice companies. Esthetic dentists should understand facial aging, as well as the basic procedures available for facial rejuvenation by the oral and maxillofacial surgeon. Contemporary esthetic dentistry goes beyond the oral cavity, and the smile is truly enhanced by simultaneous facial rejuvenation. This article discusses the process of perioral facial aging and various cosmetic facial surgery options.

  3. Efficacy of novel skin cream containing mixture of human growth factors and cytokines for skin rejuvenation.

    PubMed

    Gold, Michael H; Goldman, Mitchel P; Biron, Julie

    2007-02-01

    The crucial role of growth factors and cytokines in cutaneous wound healing is well described, but there has been little investigation into their use for skin rejuvenation. A novel skin cream containing a mixture of human growth factors and cytokines was recently marketed for skin rejuvenation. The mixture was obtained through a biotechnology process using cultured human fetal skin cells, which originate from a dedicated cell bank originally established for the development of products in wound healing. The cream significantly reduced periorbital and perioral wrinkles, as well as improved skin texture of the chin after one month of treatment, which confirms the beneficial use of growth factors and cytokines for skin rejuvenation reported in 2 earlier studies. After 60 days of twice-daily application, 83% of the subject showed an improved average wrinkle score in the eye area, while 50% showed an improved average wrinkle score in the mouth area. In order to exclude a placebo effect, the efficacy of this product should be confirmed with a double-blind, randomized, placebo-controlled study. Also, the difference between mixtures of growth factor and cytokines should be further elaborated.

  4. Minimally invasive non-thermal laser technology using laser-induced optical breakdown for skin rejuvenation.

    PubMed

    Habbema, Louis; Verhagen, Rieko; Van Hal, Robbert; Liu, Yan; Varghese, Babu

    2012-02-01

    We describe a novel, minimally invasive laser technology for skin rejuvenation by creating isolated microscopic lesions within tissue below the epidermis using laser induced optical breakdown. Using an in-house built prototype device, tightly focused near-infrared laser pulses are used to create optical breakdown in the dermis while leaving the epidermis intact, resulting in lesions due to cavitation and plasma explosion. This stimulates a healing response and consequently skin remodelling, resulting in skin rejuvenation effects. Analysis of ex-vivo and in-vivo treated human skin samples successfully demonstrated the safety and effectiveness of the microscopic lesion creation inside the dermis. Treatments led to mild side effects that can be controlled by small optimizations of the optical skin contact and treatment depth within the skin. The histological results from a limited panel test performed on five test volunteers show evidence of microscopic lesion creation and new collagen formation at the sites of the optical breakdown. This potentially introduces a safe, breakthrough treatment procedure for skin rejuvenation without damaging the epidermis with no or little social down-time and with efficacy comparable to conventional fractional ablative techniques. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  5. Minimally invasive non-thermal laser technology using laser-induced optical breakdown for skin rejuvenation

    PubMed Central

    Habbema, Louis; Verhagen, Rieko; Van Hal, Robbert; Liu, Yan; Varghese, Babu

    2012-01-01

    We describe a novel, minimally invasive laser technology for skin rejuvenation by creating isolated microscopic lesions within tissue below the epidermis using laser induced optical breakdown. Using an in-house built prototype device, tightly focused near-infrared laser pulses are used to create optical breakdown in the dermis while leaving the epidermis intact, resulting in lesions due to cavitation and plasma explosion. This stimulates a healing response and consequently skin remodelling, resulting in skin rejuvenation effects. Analysis of ex-vivo and in-vivo treated human skin samples successfully demonstrated the safety and effectiveness of the microscopic lesion creation inside the dermis. Treatments led to mild side effects that can be controlled by small optimizations of the optical skin contact and treatment depth within the skin. The histological results from a limited panel test performed on five test volunteers show evidence of microscopic lesion creation and new collagen formation at the sites of the optical breakdown. This potentially introduces a safe, breakthrough treatment procedure for skin rejuvenation without damaging the epidermis with no or little social down-time and with efficacy comparable to conventional fractional ablative techniques. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) PMID:22045580

  6. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

    PubMed Central

    Chang, Jianhui; Wang, Yingying; Shao, Lijian; Laberge, Remi-Martin; Demaria, Marco; Campisi, Judith; Janakiraman, Krishnamurthy; Sharpless, Norman E; Ding, Sheng; Feng, Wei; Luo, Yi; Wang, Xiaoyan; Aykin-Burns, Nukhet; Krager, Kimberly; Ponnappan, Usha; Hauer-Jensen, Martin; Meng, Aimin; Zhou, Daohong

    2016-01-01

    Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI)1–6. Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders7, suggesting that SCs play a causative role in certain age-related pathologies. Thus, a ‘senolytic’ pharmacological agent that can selectively kill SCs holds promise for rejuvenating tissue stem cells and extending health span. To test this idea, we screened a collection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug. We show that ABT263 selectively kills SCs in culture in a cell type– and species-independent manner by inducing apoptosis. Oral administration of ABT263 to either sublethally irradiated or normally aged mice effectively depleted SCs, including senescent bone marrow hematopoietic stem cells (HSCs) and senescent muscle stem cells (MuSCs). Notably, this depletion mitigated TBI-induced premature aging of the hematopoietic system and rejuvenated the aged HSCs and MuSCs in normally aged mice. Our results demonstrate that selective clearance of SCs by a pharmacological agent is beneficial in part through its rejuvenation of aged tissue stem cells. Thus, senolytic drugs may represent a new class of radiation mitigators and anti-aging agents. PMID:26657143

  7. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice.

    PubMed

    Chang, Jianhui; Wang, Yingying; Shao, Lijian; Laberge, Remi-Martin; Demaria, Marco; Campisi, Judith; Janakiraman, Krishnamurthy; Sharpless, Norman E; Ding, Sheng; Feng, Wei; Luo, Yi; Wang, Xiaoyan; Aykin-Burns, Nukhet; Krager, Kimberly; Ponnappan, Usha; Hauer-Jensen, Martin; Meng, Aimin; Zhou, Daohong

    2016-01-01

    Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body irradiation (TBI). Clearance of SCs in a progeroid mouse model using a transgenic approach delays several age-associated disorders, suggesting that SCs play a causative role in certain age-related pathologies. Thus, a 'senolytic' pharmacological agent that can selectively kill SCs holds promise for rejuvenating tissue stem cells and extending health span. To test this idea, we screened a collection of compounds and identified ABT263 (a specific inhibitor of the anti-apoptotic proteins BCL-2 and BCL-xL) as a potent senolytic drug. We show that ABT263 selectively kills SCs in culture in a cell type- and species-independent manner by inducing apoptosis. Oral administration of ABT263 to either sublethally irradiated or normally aged mice effectively depleted SCs, including senescent bone marrow hematopoietic stem cells (HSCs) and senescent muscle stem cells (MuSCs). Notably, this depletion mitigated TBI-induced premature aging of the hematopoietic system and rejuvenated the aged HSCs and MuSCs in normally aged mice. Our results demonstrate that selective clearance of SCs by a pharmacological agent is beneficial in part through its rejuvenation of aged tissue stem cells. Thus, senolytic drugs may represent a new class of radiation mitigators and anti-aging agents.

  8. Resistance switching in rejuvenated NaNbO3:Mn crystals

    NASA Astrophysics Data System (ADS)

    Pilch, Michal; Molak, Andrzej

    2014-11-01

    In this paper, the resistance switching effect has been studied in NaNbO3:Mn crystals. Samples were rejuvenated in ambient air, below and above antiferroelectric phase transition. Dielectric spectroscopy has exhibited weak dispersion. The influence of annealing on the electronic structure has been determined with the use of X-ray photoelectron spectroscopy. Na2s, Nb3d, O1s, and Mn2p lines of the aged as-grown crystal and the rejuvenated samples spectra have been analyzed. Nb4+ states observed in the samples point to the presence of oxygen vacancies in the surface layer. Na ions migrate toward the surface due to rejuvenation. Switching from an insulator high-resistance state to a semiconductor medium resistance and finally to a metallic-type low-resistance state has been observed. The results are discussed within the framework of the extended defects model. We propose that the aliovalent Mn2+ dopant ions stabilize the oxygen vacancies and enable the resistive switching.

  9. NASA Galaxy Mission Celebrates Sixth Anniversary

    NASA Image and Video Library

    2009-04-28

    NASA Galaxy Evolution Explorer Mission celebrates its sixth anniversary studying galaxies beyond our Milky Way through its sensitive ultraviolet telescope, the only such far-ultraviolet detector in space. Pictured here, the galaxy NGC598 known as M33. The mission studies the shape, brightness, size and distance of distant galaxies across 10 billion years of cosmic history, giving scientists a wealth of data to help us better understand the origins of the universe. One such object is pictured here, the galaxy NGC598, more commonly known as M33. This image is a blend of the Galaxy Evolution Explorer's M33 image and another taken by NASA's Spitzer Space Telescope. M33, one of our closest galactic neighbors, is about 2.9 million light-years away in the constellation Triangulum, part of what's known as our Local Group of galaxies. Together, the Galaxy Evolution Explorer and Spitzer can see a broad spectrum of sky. Spitzer, for example, can detect mid-infrared radiation from dust that has absorbed young stars' ultraviolet light. That's something the Galaxy Evolution Explorer cannot see. This combined image shows in amazing detail the beautiful and complicated interlacing of the heated dust and young stars. In some regions of M33, dust gathers where there is very little far-ultraviolet light, suggesting that the young stars are obscured or that stars farther away are heating the dust. In some of the outer regions of the galaxy, just the opposite is true: There are plenty of young stars and very little dust. Far-ultraviolet light from young stars glimmers blue, near-ultraviolet light from intermediate age stars glows green, and dust rich in organic molecules burns red. This image is a 3-band composite including far infrared as red. http://photojournal.jpl.nasa.gov/catalog/PIA11998

  10. Former Apollo astronauts speak at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo astronauts Neil Armstrong (left) and Gene Cernan entertain the audience during an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Edwin 'Buzz' Aldrin and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last.

  11. Former Apollo astronauts speak at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo astronauts Neil Armstrong (left) and Gene Cernan entertain the audience during an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Edwin 'Buzz' Aldrin and Walt Cunningham. Armstrong was the first man to walk on the moon; Cernan was the last.

  12. Former Apollo astronauts speak at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo astronauts Edwin 'Buzz' Aldrin (left) and Gene Cernan share stories about their missions for an audience attending an anniversary banquet honoring the Apollo program team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Other guests at the banquet were astronauts Wally Schirra, Gene Cernan and Walt Cunningham. Neil Armstrong was the first man to walk on the moon; Gene Cernan was the last.

  13. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong is the center of attention at the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon. He appeared at the banquet with other former astronauts Edwin 'Buzz' Aldrin, Gene Cernan, Walt Cunningham and others.

  14. Neil Armstrong chats with attendees at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Former Apollo 11 astronaut Neil A. Armstrong is the center of attention at the anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Neil Armstrong was the first man to set foot on the moon. He appeared at the banquet with other former astronauts Edwin 'Buzz' Aldrin, Gene Cernan, Walt Cunningham and others.

  15. The golden anniversary of cloning: a celebratory essay.

    PubMed

    Di Berardino, Marie A; McKinnell, Robert G; Wolf, Don P

    2003-09-01

    May 2002 marked the golden anniversary of the first cloned tadpoles. We celebrate this anniversary, as nuclear transplantation of frog cells into enucleated eggs became the prototype for cloning insects, fish, and mammals. We briefly review the salient results from amphibian cloning. Extension of these studies to mammalian species led to cloning adult cells, important advances in understanding nuclear reprogramming, and the construction of transgenic clones for biomedical applications. In addition, murine cloning clarified two problems unresolved in frog cloning: the unequivocal demonstration that nuclei of fully differentiated cells can direct the formation of fertile adults, and that abnormal expression of genes was responsible for the endoderm and neural syndromes in Rana clones.

  16. Effects of asphalt rejuvenator on thermal and mechanical properties on oxidized hot mixed asphalt pavements

    NASA Astrophysics Data System (ADS)

    Farace, Nicholas A.; Buttlar, William G.; Reis, Henrique

    2016-04-01

    The utilization of asphalt rejuvenator, and its effectiveness for restoring thermal and mechanical properties was investigated via Disk-shaped Compact Tension (DC(T)) and acoustic emission (AE) testing for determining mechanical properties and embrittlement temperatures of the mixtures. During the DC(T) testing the fracture energies and peak loads were used to measure the resistance of the rejuvenated asphalt to low temperature cracking. The AE testing monitored the acoustic emission activity while the specimens were cooled from room temperature to -40 °C to estimate the temperature at which thermal cracking began (i.e. the embrittlement temperature). First, a baseline response was obtained by obtaining the mechanical and thermal response of virgin HMA samples and HMA samples that had been exposed to oxidative aging for 36 hours at 135°C. The results showed the virgin samples had much higher peak loads and fracture energies than the 36 hours aged samples. Acoustic Emission showed similar results with the virgin samples having embrittlement temperatures 10 °C cooler than the 36 hours aged specimens. Then, overaged for 36 hours specimens were treated different amounts of rejuvenator (10%, 15%, and 20% by weight of binder content) and left to dwell for increased amount of time periods varying from one to eight weeks. It was observed that the AE results showed an improvement of embrittlement temperature with increasing with the dwell times. The 8 weeks specimens had cooler embrittlement temperatures than the virgin specimens. Finally, the low temperature effects on fracture energy and peak load of the rejuvenated asphalt was investigated. Rejuvenator was applied (10% by weight of binder) to specimens aged 36 hours at 135 °C, and the dwell time was varied from 1 to 4 weeks. The results showed that the peak loads were restored to levels of the virgin specimens, and the fracture energies improved to levels beyond that of the virgin specimens. The results also showed a

  17. Evaluating and Modeling the Internal Diffusion Behaviors of Microencapsulated Rejuvenator in Aged Bitumen by FTIR-ATR Tests

    PubMed Central

    Su, Junfeng; Wang, Yingyuan; Yang, Peng; Han, Shan; Han, Ningxu; Li, Wei

    2016-01-01

    Microencapsulated rejuvenator has been attracted much attention for self-healing bitumen. The diffusion coefficient is one of the key parameters to estimate the feasibility of rejuvenator to age bitumen. The objective of this research was to evaluate diffusion behaviors of microencapsulated rejuvenator in aged bitumen by a FTIR-ATR method. Various microcapsule samples were mixed in bitumen to form thin films. The core material of microcapsules used as rejuvenator was diphenylsilane (DPS), its fairly specific absorption band at 843 cm−1 was selected as a marker band to calculate the diffusion coefficient (D). The microstructure parameters, including contents, mean size and mean shell thickness of microcapsules, were considered to understand the diffusion behaviors under different temperatures (20, 30, 40 and 50 °C) in bitumen. The results showed that a larger mean size of microcapsules did not greatly affect the D values under the same temperature. In contrast, a higher mean shell thickness decreased the D values because of the decrement of damage probability of microcapsules under the same content. With the same microcapsule sample in bitumen, the D values presented a trend of linear increase when the content of microcapsules was increased. All these results indicated that the microstructure affected the diffusion behaviors based on the concentration of released rejuvenator. A preliminary model of diffusion behaviors of microencapsulated rejuvenator in bitumen was given based on the Arrhenius equation considering the microstructure of microcapsules, the amount of released rejuvenator and the age degree of bitumen. This model may be a guide to the construction and application of self-healing bitumen using microcapsules. PMID:28774052

  18. Speech Association of America Golden Anniversary Convention Program, Supplement.

    ERIC Educational Resources Information Center

    Speech Association of America, New York, NY.

    The material in this publication was compiled to commemorate the fiftieth anniversary, in 1964, of the founding of the Speech Association of America (now the Speech Communication Association). Contents include introductory comments by James M. O'Neill, the first president, and Robert T. Oliver, president in 1964; articles on the founding and…

  19. 100th Anniversary of the Juvenile Court, 1899-1999.

    ERIC Educational Resources Information Center

    Juvenile Justice, 1999

    1999-01-01

    This issue commemorates the 100th anniversary of the creation of the juvenile court and the recognition that the developmental differences between children and adults require differences in the ways they are treated by the court system. The feature article, "An Evolving Juvenile Court: On the Front Lines with Judge J. Dean Lewis," reviews the…

  20. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn's wife Annie listens to an interviewers question during a celebration dinner at The Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  1. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn and his wife Annie listen to speakers during a reception at Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  2. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn and his wife Annie talk during a celebration dinner at The Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  3. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn and his wife Annie take the stage during a celebration dinner at The Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  4. Beyond Discipline: From Compliance to Community. 10th Anniversary Edition

    ERIC Educational Resources Information Center

    Kohn, Alfie

    2006-01-01

    In this 10th anniversary edition of an Association for Supervision and Curriculum Development (ASCD) best seller, the author reflects on his revolutionary ideas in the context of today's emphasis on school accountability and high-stakes testing. The author relates how his innovative approach--where teachers learn to work with students, rather than…

  5. Universal Declaration of Human Rights: 40th Anniversary.

    ERIC Educational Resources Information Center

    Adams, Juanita, Ed.

    December 10, 1988, marks the 40th anniversary of the adoption by the United Nations of the Universal Declaration of Human Rights. The Declaration represents the first comprehensive, global statement on basic human rights, embracing many of the values long held by U.S. citizens; and it urges all peoples and all nations to promote respect for the…

  6. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Apollo 11 Astronaut Neil Armstrong speaks during a celebration dinner at Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  7. Avation Safety Reporting System (ASRS) 40th Anniversary.

    NASA Image and Video Library

    2016-09-28

    Avation Safety Reporting System (ASRS) 40th Anniversary lunch and open house at the Sunnyvale office. Linda J. Connell, ASRS Program Director (Left); Thomas A Edwards, Deputy Center Director NASA Ames; Dr. John Lauber, Resident Scientist and pioneer of the ASRS at Ames from 1972-1985 (Right).

  8. Views of the Apollo 11 Twentieth Anniversary Black Tie reception

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Views of the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Views include former JSC Directors Robert Gilruth and Christopher C. Kraft Jr. reminiscing with keynote speaker Walter Cronkite (39934); Apollo astronauts Tom Stafford (left) and Neil Armstrong (right) talk with former Soviet cosmonaut Alexei Leonov (center) at the gala (39935).

  9. Perspectives and Horizons. Dimension: Languages '89. Silver Anniversary Conference.

    ERIC Educational Resources Information Center

    Fryer, T. Bruce, Ed.; Medley, Frank W., Jr., Ed.

    In 1989, the Southern Conference on Language Teaching (SCOLT) celebrated its silver anniversary at a conference designed to provide participants with an opportunity both to reflect on the past and to look at the future of foreign language teaching and of SCOLT in the light of a quarter century of experience. Seven of the papers in this volume were…

  10. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn, left, and Apollo 11 Astronaut Neil Armstrong are seen prior to the start of a dinner at Ohio State University that honored the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  11. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Ohio State University student Joanna Fedeli interviews Sen. John Glenn and his wife Annie during a celebration dinner at Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  12. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn and NASA Deputy Administrator Lori Garver pose for a photograph during a celebration dinner at Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  13. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn, left, and NASA Administrator Charles Bolden address questions from the press during a briefing at Ohio State University on Monday, Feb. 20, 2012, in Columbus, Ohio. Today marks the 50th anniversary of Glenn's historic flight. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  14. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn speaks to guest at NASA's Future Forum at Ohio State University on Monday, Feb. 20, 2012, in Columbus, Ohio. Today marks the 50th anniversary of Glenn's historic flight. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  15. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn, left, and NASA Administrator Charles Bolden speak to guest at NASA's Future Forum at Ohio State University on Monday, Feb. 20, 2012, in Columbus, Ohio. Today marks the 50th anniversary of Glenn's historic flight. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  16. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn poses for a portrait shortly after doing live television interviews from the Ohio State University Union building on Monday, Feb. 20, 2012, in Columbus, Ohio. Today marks the 50th anniversary of his historic flight. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  17. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    NASA Administrator Charles Bolden, seated right, and Sen. John Glenn address questions from the press during a briefing at Ohio State University as John Glenn's wife Annie Glenn, seated in red, looks on Monday, Feb. 20, 2012, in Columbus, Ohio. Today marks the 50th anniversary of Glenn's historic flight. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  18. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn address questions from the press during a briefing at Ohio State University on Monday, Feb. 20, 2012, in Columbus, Ohio. Today marks the 50th anniversary of Glenn's historic flight. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  19. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn talks on stage during a celebration dinner at The Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  20. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    Sen. John Glenn's wife Annie, right, and NASA Deputy Administrator Lori Garver pose for a photograph during a celebration dinner at Ohio State University honoring the 50th anniversary of John Glenn's historic flight aboard Friendship 7 Monday, Feb. 20, 2012, in Columbus, Ohio. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  1. 50th Anniversary First American to Orbit Earth

    NASA Image and Video Library

    2012-02-20

    NASA Administrator Charles Bolden answers a question from the press during a briefing at Ohio State University on Monday, Feb. 20, 2012, in Columbus, Ohio. Today marks the 50th anniversary of Glenn's historic flight. Glenn was the first American to orbit Earth. Photo Credit: (NASA/Bill Ingalls)

  2. Views of the Apollo 11 Twentieth Anniversary Black Tie reception

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Views of the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Views include former JSC Directors Robert Gilruth and Christopher C. Kraft Jr. reminiscing with keynote speaker Walter Cronkite (39934); Apollo astronauts Tom Stafford (left) and Neil Armstrong (right) talk with former Soviet cosmonaut Alexei Leonov (center) at the gala (39935).

  3. Views of the Apollo 11 Twentieth Anniversary Black Tie reception

    NASA Image and Video Library

    1989-07-25

    Views of the Apollo 11 Twentieth Anniversary Black Tie reception at the downtown Houston Hyatt Regency Hotel. Views include former JSC Directors Robert Gilruth and Christopher C. Kraft Jr. reminiscing with keynote speaker Walter Cronkite (39934); Apollo astronauts Tom Stafford (left) and Neil Armstrong (right) talk with former Soviet cosmonaut Alexei Leonov (center) at the gala (39935).

  4. Editorial: Celebration of Optics Letters' 40th Anniversary.

    PubMed

    Zhang, Xi-Cheng

    2017-01-01

    Editor-in-Chief Xi-Cheng Zhang recognizes the 40th anniversary of Optics Letters, reflects on the standing of the journal in the optics and photonics community, and announces the special features that will mark the occasion throughout 2017.

  5. The 70th anniversary of the death of Lou Gehrig.

    PubMed

    Brennan, Frank

    2012-11-01

    The year 2011 marked the 70th anniversary of the death of Lou Gehrig. This article reviews his history, illness, relationship with his physicians, and what the modern physician can learn from his story. Lou Gehrig's disease continues to be the popular eponym for amyotrophic lateral sclerosis.

  6. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    Brenda Manuel, Associate Administrator for Diversity and Equal Opportunity at NASA gives opening remarks at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. the event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  7. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    The Military District of Washington Armed Forces Color Guard presents the colors at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  8. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    NASA Associate Administrator Robert Lightfoot delivers closing remarks at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  9. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    A member of the audience asks a questions during a moderated panel discussion at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  10. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    Omega Jones sings the national anthem as a color guard from the at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  11. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    NASA Administrator Charles Bolden watches as a video entitled "50 Years After" plays at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  12. Spinoff 2002: Fortieth Anniversary Technology Utilization Program

    NASA Technical Reports Server (NTRS)

    2002-01-01

    . Each section of Spinoff 2002 provides compelling evidence of the Technology Transfer Program's success and value. With commercial products and successes spanning from work on the Apollo missions to the International Space Station, the 40th anniversary of the Technology Transfer Program invites us to celebrate our history while planning the future.

  13. Fluoxetine tenth anniversary update: the progress continues.

    PubMed

    Stokes, P E; Holtz, A

    1997-01-01

    This tenth anniversary review/update of fluoxetine concentrates on the past 5 years of its clinical application. The mechanism of action of fluoxetine; its metabolism; its efficacy in patients with various diagnostic subgroups of depression, patients with coincident medical disease, children and adolescents with depression, patients with eating disorders, and patients with obsessive-compulsive disorder (OCD); its long-term (maintenance) efficacy; its side effects and toxicity; and pharmacoeconomic considerations are reviewed. Pharmacotherapy is currently the only proven method for treating major depressive disorder that is applicable to all levels of severity of major depressive illness. Since its introduction 10 years ago, fluoxetine has been available to psychiatrists, primary care physicians, and other nonpsychiatric physicians as full-dose effective pharmacotherapy for patients with depression. Fluoxetine has been widely prescribed by physicians knowledgeable in pharmacology and in the treatment of depression because of its proven efficacy (ie, equal to that of tricyclic antidepressants [TCAs]), its ease of administration (with full therapeutic dosing usually starting from day 1), its generally benign side-effect profile, its remarkable safety in over-dose, and its proven effectiveness in the most common depressed patient population--anxious, agitated, depressed patients--as well as in patients with various subtypes and severities of depression. In more recent years it has also proved effective in the treatment of bulimia, an entity for which only limited or inadequate treatment options had been previously available. In OCD, fluoxetine, with its more acceptable side-effect profile and greater ease of dosing, presents a favorable alternative to previous drug therapy and is useful in treating both obsessions and compulsions. Fluoxetine is currently recognized among clinicians as efficacious in treating anxiety disorders and is being used successfully in special

  14. The AAS Visiting Professor Programs: Three Anniversaries

    NASA Astrophysics Data System (ADS)

    Philip, A. G. Davis

    2003-05-01

    . Shapley visits have been made to Canadian institutions since 1976 and to Mexican institutions since 1998. After the summer meeting it will be the start of the 10th year of my directing the program. On May 26 there will be a Shapley Dinner at Dyer Observatory in Nashville for the Shapley lecturers who are attending the AAS meeting and we will celebrate these three anniversaries.

  15. NASA Galaxy Mission Celebrates Sixth Anniversary

    NASA Image and Video Library

    2009-04-28

    NASA Galaxy Evolution Explorer Mission celebrates its sixth anniversary studying galaxies beyond our Milky Way through its sensitive ultraviolet telescope, the only such far-ultraviolet detector in space. The mission studies the shape, brightness, size and distance of distant galaxies across 10 billion years of cosmic history, giving scientists a wealth of data to help us better understand the origins of the universe. One such object is pictured here, the galaxy NGC598, more commonly known as M33. This image is a blend of the Galaxy Evolution Explorer's M33 image and another taken by NASA's Spitzer Space Telescope. M33, one of our closest galactic neighbors, is about 2.9 million light-years away in the constellation Triangulum, part of what's known as our Local Group of galaxies. Together, the Galaxy Evolution Explorer and Spitzer can see a broad spectrum of sky. Spitzer, for example, can detect mid-infrared radiation from dust that has absorbed young stars' ultraviolet light. That's something the Galaxy Evolution Explorer cannot see. This combined image shows in amazing detail the beautiful and complicated interlacing of the heated dust and young stars. In some regions of M33, dust gathers where there is very little far-ultraviolet light, suggesting that the young stars are obscured or that stars further away are heating the dust. In some of the outer regions of the galaxy, just the opposite is true: There are plenty of young stars and very little dust. Far-ultraviolet light from young stars glimmers blue, near-ultraviolet light from intermediate age stars glows green, near-infrared light from old stars burns yellow and orange, and dust rich in organic molecules burns red. The small blue flecks outside the spiral disk of M33 are most likely distant background galaxies. This image is a four-band composite that, in addition to the two ultraviolet bands, includes near infrared as yellow/orange and far infrared as red. http://photojournal.jpl.nasa.gov/catalog/PIA11999

  16. CP-1 70th Anniversary Symposium

    ScienceCinema

    Len Koch; Harold Agnew

    2016-07-12

    Dr. Harold Agnew, retired director of Los Alamos National Laboratory and one of 49 people present on December 2, 1942 when the world’s first man-made controlled nuclear chain reaction was achieved with the CP-1 reactor, and Dr. Len Koch, one of Argonne’s earliest staff members and a designer of EBR-I, the first liquid metal-cooled fast reactor, spoke about their early work during “The Dawn of the Nuclear Age”, a Director’s Special Symposium held as one of the events to commemorate the 70th anniversary year of CP-1 achieving criticality. The symposium was moderated by Dr. Charles Till, a retired Argonne associate laboratory director who led Argonne’s nuclear engineering programs throughout the 1980’s and ‘90’s. Dr. Agnew painted a vivid picture of the challenges and rewards of working in Enrico Fermi’s group under strict security conditions and the complete faith all in the group had in Fermi’s analyses. He stated that no one ever doubted that CP-1 would achieve criticality, and when the moment came, those present acknowledged the accomplishment with little more than a subdued toast of chianti from a bottle provided by reactor physicist Eugene Wigner. This experimental work on nuclear reactors was continued in the Chicago area and led first by Fermi and then Walter Zinn, another member of Fermi’s CP-1 group, resulting in the formal establishment of Argonne National Laboratory on July 1, 1946. Dr. Koch described how much he enjoyed working at Argonne through the 1950’s and ‘60’s and contributing to many of the research “firsts” that Argonne achieved in the nuclear energy field and led to the foundation of the commercial nuclear power generation industry. His reminiscences about all that was achieved with EBR-I and how that work then led into Argonne’s design, building, and operation of EBR-II as a full demonstration of a fast reactor power plant brought Argonne’s nuclear

  17. Administratium: A 20th-Anniversary Update

    NASA Astrophysics Data System (ADS)

    DeBuvitz, William

    2009-01-01

    experience. I wrote an article that was published in the May 2005 issue and I extended the "Administratium" story to include newly discovered chemical properties. At the 20th anniversary of its publication, I feel it is important to clear up any question about the authorship in the magazine that first published the story.

  18. CP-1 70th Anniversary Symposium

    SciTech Connect

    Len Koch; Harold Agnew

    2012-07-11

    Dr. Harold Agnew, retired director of Los Alamos National Laboratory and one of 49 people present on December 2, 1942 when the world’s first man-made controlled nuclear chain reaction was achieved with the CP-1 reactor, and Dr. Len Koch, one of Argonne’s earliest staff members and a designer of EBR-I, the first liquid metal-cooled fast reactor, spoke about their early work during “The Dawn of the Nuclear Age”, a Director’s Special Symposium held as one of the events to commemorate the 70th anniversary year of CP-1 achieving criticality. The symposium was moderated by Dr. Charles Till, a retired Argonne associate laboratory director who led Argonne’s nuclear engineering programs throughout the 1980’s and ‘90’s. Dr. Agnew painted a vivid picture of the challenges and rewards of working in Enrico Fermi’s group under strict security conditions and the complete faith all in the group had in Fermi’s analyses. He stated that no one ever doubted that CP-1 would achieve criticality, and when the moment came, those present acknowledged the accomplishment with little more than a subdued toast of chianti from a bottle provided by reactor physicist Eugene Wigner. This experimental work on nuclear reactors was continued in the Chicago area and led first by Fermi and then Walter Zinn, another member of Fermi’s CP-1 group, resulting in the formal establishment of Argonne National Laboratory on July 1, 1946. Dr. Koch described how much he enjoyed working at Argonne through the 1950’s and ‘60’s and contributing to many of the research “firsts” that Argonne achieved in the nuclear energy field and led to the foundation of the commercial nuclear power generation industry. His reminiscences about all that was achieved with EBR-I and how that work then led into Argonne’s design, building, and operation of EBR-II as a full demonstration of a fast reactor power plant brought Argonne’s nuclear energy legacy to life for everyone in the auditorium. These

  19. Petrology and geochronology of lavas from Ka'ula Volcano: Implications for rejuvenated volcanism of the Hawaiian mantle plume

    NASA Astrophysics Data System (ADS)

    Garcia, Michael O.; Weis, Dominique; Jicha, Brian R.; Ito, Garrett; Hanano, Diane

    2016-07-01

    Marine surveying and submersible sampling of Ka'ula Volcano, located 100 km off the axis of the Hawaiian chain, revealed widespread areas of young volcanism. New 40Ar/39Ar and geochemical analyses of the olivine-phyric submarine and subaerial volcanic rocks show that Ka'ula is shrouded with 1.9-0.5 Ma alkalic basalts. The ages and chemistry of these rocks overlap with rejuvenated lavas on nearby, northern Hawaiian Island shields (Ni'ihau, Kaua'i and South Kaua'i Swell). Collectively, these rejuvenated lavas cover a vast area (∼7000 km2), much more extensive than any other area of rejuvenated volcanism worldwide. Ka'ula rejuvenated lavas range widely in alkalinity and incompatible element abundances (e.g., up to 10× P2O5 at a given MgO value) and ratios indicating variable degrees of melting of a heterogeneous source. Heavy REE elements in Ka'ula lavas are pinned at a mantle normalized Yb value of 10 ± 1, reflecting the presence of garnet in the source. Trace element ratios indicate the source also contained phlogopite and an Fe-Ti oxide. The new Ka'ula ages show that rejuvenated volcanism was nearly coeval from ∼0.3 to 0.6 Ma along a 450 km segment of the Hawaiian Islands (from West Maui to north of Ka'ula). The ages and volumes for rejuvenated volcanism are inconsistent with all but one geodynamic melting model proposed to date. This model advocates a significant contribution of pyroxenite to rejuvenated magmas. Analyses of olivine phenocryst compositions suggest a major (33-69%) pyroxenite component in Ka'ula rejuvenated lavas, which correlates positively with radiogenic Pb isotope ratios for Ka'ula. This correlation is also observed in lavas from nearby South Kaua'i lavas, as was reported for Atlantic oceanic islands. The presence of pyroxenite in the source may have extended the duration and volume of Hawaiian rejuvenated volcanism.

  20. ‘Recharge My Exhausted Batteries’: Overbeck’s Rejuvenator, Patenting, and Public Medical Consumers, 1924–37

    PubMed Central

    Stark, James F.

    2014-01-01

    Although historians have shown that there has been a complex and multi-layered relationship between the body, medicine and the force of electricity, many avenues remain to be explored. One of the most prominent of these is the way in which electrotherapy technologies were marketed to a wide variety of different end users and intermediaries. This paper offers the first historical analysis of one such device – the Overbeck Rejuvenator – a 1920s electrotherapy machine designed for use by the general public. Its inventor, Otto Overbeck, was not a medical man and this enabled him to use aggressive strategies of newspaper advertising, using testimonials to market his product alongside appeals to his own scientific authority. He commissioned the prestigious Ediswan Company to manufacture the Rejuvenator on a large scale, and took out patents in eleven countries to persuade users of the efficacy of the device. In response to Overbeck’s activities, the British Medical Association enlisted an electrical engineer to examine the Rejuvenator, contacted practitioners whose endorsements were being used in publicity material, and denied Overbeck permission to advertise in the British Medical Journal. Despite this, the Rejuvenator brought its inventor wealth and notoriety, and helped redefine the concept of ‘rejuvenation’, even if the professional reception of such a device was almost universally hostile. This paper shows how the marketing, patenting and publishing of Overbeck combined to persuade members of the laity to try the Rejuvenator as an alternative form of therapy, bypassing the medical profession in the process. PMID:25284892

  1. Anatomic predictors of unsatisfactory outcomes in surgical rejuvenation of the midface.

    PubMed

    Jacono, Andrew A; Ransom, Evan R

    2013-03-01

    To aid the aesthetic surgeon in midface analysis and selection of treatment plans offering the greatest likelihood of success in midface rejuvenation. We performed a retrospective review of all patients who underwent surgical midface rejuvenation by a single surgeon. We recorded demographics, history, procedures, outcomes, and complications. Results of physical examination and photography were used to classify patients by volume loss, midface ptosis, skin elasticity, and skeletal anatomy. Outcome was determined by patient satisfaction at the 12-month follow-up; unsatisfactory results were further analyzed by a blinded independent expert with more than 15 years' experience. We included 150 patients. Mean patient age was 51 years; 93.3% were women, and 20.7% had undergone previous procedures, including malar implants, autologous fat grafting, rhytidectomy, midface-lift, and extended lower blepharoplasty. Multimodality treatment was used in 34.0%. Patient dissatisfaction was encountered in 14.0% of cases; the expert concurred in each case. Autologous fat grafting alone demonstrated the greatest propensity for dissatisfaction (4 of 12 cases [33%]). Rate of dissatisfaction was significantly higher with malar hypoplasia (41% vs 7%; P < .001) or loss of elasticity (16% vs 3%; P = .01) but was not highly correlated with age (r = 0.15). Successful midface rejuvenation requires accurate diagnosis and avoidance of anatomic pitfalls. Many patients require multimodality therapy, including lifting and volumizing techniques. Unsatisfactory results are most common when midfacial aging is accompanied by skeletal insufficiency or loss of elasticity. Respective consideration of these defects should be given to placement of malar implants and rhytidectomy approaches targeting the midface.

  2. The apparent groundwater age rejuvenation caused by the human activity in Jakarta area, Indonesia

    NASA Astrophysics Data System (ADS)

    Kagabu, M.; Shimada, J.; Nakamura, T.; Delinom, R.; Taniguchi, M.

    2010-12-01

    The rapid urbanization in Jakarta area has become a serious subsurface environmental issues such as groundwater level decline and land subsidence due to excessive groundwater pumping. These problems began to emerge recently by some hydrological studies. The comparison of 14C activity between 1985 and 2008 shows the apparent groundwater age rejuvenation in the deep aquifer under the DKI Jakarta. We discussed by using a numerical groundwater flow model to evaluate the process of this rejuvenation in the urbanized area. Since the groundwater pumping was not performed intensely, the groundwater discharge flow toward the sea coast was dominant until 1983, however, this outward flux switched to intrusion flux into deeper aquifer after mid-1980s because of over-pumping in the urban area. The most largest flux among six flux directions toward the deep aquifer under the DKI Jakarta became “vertical downward flux” which means the shallower groundwater intrude into the deep one due to the excessive groundwater pumping from mid-1980s and this flux grows about 50% in 2000s. This result is consistent with the detection of chlorofluorocarbon (CFC)-12, which works as an indicator of young groundwater even in the deep groundwater. As the rejuvenation ratio “R” was determined by using 14C activity in the groundwater, R increase with the CFC-12 concentration and boths have good correlation. Besides, we estimated the “vertical downward flux” at each well's screen depth by the model estimation. The result shows that this flux has larger in the urban groundwater depression area and especially at shallower part of the deep aquifer, and it affects the magnitude of the shallow groundwater intrusion. Relationship between R and CFC-12 concentration. The diameter of cube shows the magnitude of the “vertical downward flux”

  3. Effect of asphalt rejuvenating agent on aged reclaimed asphalt pavement and binder properties

    NASA Astrophysics Data System (ADS)

    Sabahfar, Nassim

    Hot in-place recycling (HIR) preserves distressed asphalt pavements while minimizing use of virgin binder and aggregates. The final quality of an HIR mixture depends on characteristics of the original binder, aging of the pavement surface during service, and whether or not new binder or rejuvenator was added to the mixture. An HIR mixture should maintain desired properties for additional service periods, making asphalt binder modification inevitable. Asphalt binder modifications in HIR are commonly done by adding an asphalt rejuvenating agent (ARA). However, ARA may adversely affect the qualities of new HIR and potentially fail to improve the quality of the final surface. The objective of this research was to investigate the effects of rejuvenation on HIR performance characteristics by assessing critical performance indicators such as stiffness, permanent deformation, moisture susceptibility, and cracking resistance. A two-step experimental program was designed that included mechanical property measurements of the HIR mixture and rheological properties of the extracted binder. The level of mixing occurring between new and aged binder with ARA was also investigated. HIR Samples were obtained from three Kansas Department of Transportation projects, and Hamburg wheel-tracking device, dynamic modulus, flow number, Texas overlay, thermal stress restrained specimen, and moisture susceptibility tests were conducted on mixtures with and without ARA. Rheological studies on the extracted binder included dynamic shear rheometer and bending beam rheometer tests. The miscibility of new and aged binder was investigated using scanning electron microscope (SEM) images, energy dispersive X-ray spectroscopy (EDXS), and the exudation droplet test (EDT). Study results showed significant variability in the mechanical performance of HIR mixtures, which was attributed to the variability of binders as observed in EDT, SEM and EDXS studies. Life cycle cost analysis (LCCA) showed that HIR

  4. Ursolic acid ameliorates aging-metabolic phenotype through promoting of skeletal muscle rejuvenation.

    PubMed

    Bakhtiari, Nuredin; Hosseinkhani, Saman; Tashakor, Amin; Hemmati, Roohullah

    2015-07-01

    Ursolic acid (UA) is a lipophilic compound, which highly found in apple peels. UA has some certain features, of the most important is its anabolic effects on skeletal muscles, which in turn plays a prominent role in the aging process, encouraged us to evaluate skeletal muscle rejuvenation. This study seeks to address the two following questions: primarily, we wonder to know if UA increases anti-aging biomarkers (SIRT1 and PGC-1α) in the isolated satellite cells, to pave the way for satellite cells proliferation. The results revealed that UA elevated the expression of SIRT1 (∼ 35 folds) and PGC-1α (∼ 175 folds) genes. The other question that needs to be asked, however, is to understand whether it is possible to generalize the in vitro findings to in vivo. For this, a study was designed to investigate the effects of UA on the cellular energy status in the animal models (C57BL/6 mice). We found that UA decreased cellular energy charges such as ATP (∼ 3 times) and ADP (∼ 18 times). With respect to the role of UA in energy expenditure and as an anti-aging biomarker, one might wonder to elucidate skeletal muscle rejuvenation as well as satellite cells proliferation and neomyogenesis. The results illustrated that UA boosted neomyogenesis through enhancing the number of satellite cells. In addition, rejuvenation effects of UA on the skeletal muscle promptly encouraged us to reexamine the performance of skeletal muscles. The results indicated that UA through increasing myoglobin expression (∼ 2 folds) accompanied with transforming of glycolytic to fast oxidative status chiefly and slow-twitch muscle fibers. To the best of our knowledge, it seems that UA might be considered as a potential candidate for treatment of pathological conditions associated with muscular atrophy and dysfunction, including skeletal muscle atrophy, amyotrophic lateral sclerosis (ALS), sarcopenia and metabolic diseases of the muscles.

  5. Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians.

    PubMed

    Chan, Nicola P Y; Ho, Stephanie G Y; Yeung, Chi K; Shek, Samantha Y N; Chan, Henry H

    2010-11-01

    Ablative fractional resurfacing (AFR) is a new modality for photorejuvenation and acne scars which combines carbon dioxide (CO₂) laser ablation with fractional photothermolysis. The objective is to evaluate the efficacy and side effects of a new fractional CO₂ ablative device (Fraxel Re:pair) for skin rejuvenation and acne scars in Asians. Nine patients underwent one full-face treatment. The energy levels ranged from 30-70 mJ with coverage between 30% and 45%. Improvement in skin texture, laxity, wrinkles, enlarged pores, overall pigmentation irregularity, and adverse effects were assessed up to 6 months post-treatment. Standardized photographs using the Canfield Visia CR system® were assessed by two independent observers. Subjective improvement was assessed by patient questionnaires. Nine Chinese patients (skin types III and IV, mean age 44.8) were included. Statistically significant improvements were seen for skin texture, skin laxity, wrinkles, enlarged pores, and acne scars. The post-inflammatory hyperpigmentation rate was 55.5% and 11.1% at 1 and 6 months post-treatment, respectively. Eighty-six percent of patients were overall satisfied to very satisfied with the treatment. Ablative fractional CO₂ laser resurfacing was overall safe and effective for skin rejuvenation and acne scars in Asians. However, in view of the high post-inflammatory rate and the statistically significant but only mild to moderate improvement after a single treatment as observed in this study, there is a need to review the current role of fractional ablative CO₂ laser treatment as compared to fractional non-ablative for skin rejuvenation and acne scar treatment in Asians. © 2010 Wiley-Liss, Inc.

  6. A policy analysis of funding for ambitious interventional gerontology: the possibility of rejuvenation research at the National Institute on Aging.

    PubMed

    Mackey, Tom

    2004-01-01

    Issues related to the development of ambitious interventional gerontology-rejuvenation research-at the National Institute on Aging (NIA) within the National Institutes of Health (NIH) are discussed. Creating a separate branch for rejuvenation research within the NIA is probably neither feasible nor desirable at this time. However, it may be both feasible and desirable to begin rejuvenation research by establishing a bioengineering laboratory offering technologies that complement the disease-orientated focus of other NIA intramural laboratories. Such a bioengineering lab could use modern engineering tools for cell and gene therapies to uncover mechanisms of aging and to attempt to repair age-associated pathogenic damage. It is argued that, even in the absence of a full understanding of the complex causes and manifestations of human aging, interventional bioengineering could create methods for reversing aging processes. Exploring technical interventions may both reverse aging processes and significantly advance current disease-specific research.

  7. ["Rejuvenation" as the outcome of research on aging: dreams and theories--experiments and results].

    PubMed

    Hahn, S

    1992-10-01

    A report is given on experiments of rejuvenation which were carried out in the first decenniums of the 20th century. The knowledge of the effect of sexual hormones on the one hand and still missing possibilities of synthesisation on the other gave rise to spectacular transplantations and further operation techniques as well as physical forms of therapy on testicles and ovaries. The fundaments of the scientific theory and the social backgrounds of these side branches of gerontology which established itself only at the end of the thirties are mentioned.

  8. Reversible transition of deformation mode by structural rejuvenation and relaxation in bulk metallic glass

    NASA Astrophysics Data System (ADS)

    Meng, Fanqiang; Tsuchiya, Koichi; Seiichiro; Yokoyama, Yoshihiko

    2012-09-01

    A transition of the deformation mode from heterogeneous, localized deformation to homogeneous deformation was observed in Zr50Cu40Al10 bulk metallic glass (BMG) by giant straining using the high-pressure torsion (HPT) method. The transition is accompanied by a pronounced decrease in hardness and elastic modulus as measured by nanoindentation. Annealing of the deformed BMG resulted in the restoration of the localized deformation, hardness, and elastic modulus; thus, the transition is reversible. The observed reversible transition can be attributed to a change in the local atomic environment in the rejuvenated volume and the relaxed one.

  9. Molecular and Cellular Interactions between Mother and Fetus. Pregnancy as a Rejuvenating Factor.

    PubMed

    Popkov, V A; Silachev, D N; Jankauskas, S S; Zorova, L D; Pevzner, I B; Babenko, V A; Plotnikov, E Y; Zorov, D B

    2016-12-01

    Aging is associated with a decline of various body functions, including ability to regenerate. Over recent decades, it has been demonstrated that some of these changes could be reversed in response to factors originating from a young organism, for example, fetal stem cells or "young blood" in models of heterochronic parabiosis. Pregnancy might be considered as parabiotic model of the interaction between two organisms of different age. In this work, we analyzed and summarized data on the effects of pregnancy on the maternal organism that confirm the hypothesis that pregnancy rejuvenates the mother's organism or slows its aging.

  10. Comprehensive treatment of the aging face--cutaneous and structural rejuvenation.

    PubMed

    Sherris, D A; Otley, C C; Bartley, G B

    1998-02-01

    As people age, characteristic changes occur in the skin, the soft tissue envelope, and the bony skeleton of the face and result in the aging face syndrome. An understanding of the pertinent biomechanical and histologic changes is necessary for developing an appropriate treatment plan. The advent of many new techniques, including cosmetic exfoliation, laser skin resurfacing, open rhinoplasty, and endoscopic, multiplane plastic surgical procedures, has enhanced therapy for the aging face syndrome. Treatment protocols should be individualized for each patient's needs and desires. Several of these recent treatments for facial rejuvenation are reviewed herein.

  11. Hand rejuvenation using standard Intense Pulsed Light (IPL) in Asian patients

    PubMed Central

    Maruyama, Seiichi

    2016-01-01

    Background: In recent years, facial rejuvenation using Intense Pulsed Light (IPL) is in demand and there have been many reports. However, hand rejuvenation, which aims to treat lentigines on the dorsal hand and wrinkles, is in demand but with few reports. In this study, hand rejuvenation was attempted using two wavelengths of a standard IPL system. It focuses mainly on improvement of lentigines, and efficacy on wrinkles on the dorsal hand will be discussed as well. Subjects and Methods: The subjects were 128 Japanese patients (average age 58.1) who had lentigines and wrinkles on the dorsa of both hands, and the wavelength spectra of 560 – 1200 nm and 515 – 1200 nm were applied. In general, the number of treatments was not fixed, and further treatments beyond the first treatment were added only when asked for by the patient. Lentigines were assessed on 4 levels and wrinkles on 3 levels. Results: The results in lentigines were graded “Excellent” in 45.3%, “Good” in 14.8%, “Unchanged” in 37.5% and “Bad” in 2.3% of the patients. Dark-toned lentigines in particular improved after one treatment. On the other hand, the results in wrinkles were graded as “Effective” in 25.0%, “Hard to tell” in 39.1% and “Ineffective” in 35.9% of the patients after the first treatment, but there was increased improvement in some cases after multiple treatments. Conclusions: By using appropriate IPL parameters with specific cut-off filters, dark-toned and flat senile lentigines could be treated effectively with a small number of treatments. On the other hand, improvement of fine dorsal wrinkles was noticed but more finesse is needed as to how to apply IPL and to decide on the number of treatments. Further study is necessary, but overall it can be said that IPL is an effective choice for hand rejuvenation. PMID:27141154

  12. Large volumes of rejuvenated volcanism in Samoa: Evidence supporting a tectonic influence on late-stage volcanism

    NASA Astrophysics Data System (ADS)

    Konter, Jasper G.; Jackson, Matthew G.

    2012-06-01

    Hot spot volcanoes are commonly constructed in a characteristic sequence of stages. After the volumetrically dominant shield stage, a protracted period of quiescence ends with a final stage of activity: rejuvenated volcanism. The mechanism responsible for generating rejuvenated volcanism is not generally agreed upon. New data obtained for samples 200 m down-section in a deeply incised canyon on Savai`i (Samoa) are unusually enriched isotopically and indicate a relatively voluminous rejuvenated stage compared to other intraplate volcanoes. Using a modified flexural model originally proposed for Hawai`i, we suggest that the location of Samoa near the Tonga Trench terminus causes plate flexure resulting in upward flow of the shallow mantle driving partial melting. In particular, subduction-related plate bending in the Samoan region may cause a larger flexural amplitude than generated by volcanic loading in Hawai`i. The larger amplitude may explain the larger volume of rejuvenated melt in Samoa, constrained by our new data. Moreover, we argue that Sr-Nd-Pb-Os-He-Ne isotopes in Samoan rejuvenated lavas are all consistent with sampling of a lithospheric component that is characterized by a metasomatic imprint from the Pacific Plate's earlier passage over the Rarotonga hot spot. Furthermore, temperature estimates for the melts suggest a drop in temperature during the predicted shallower melting due to flexural uplift, compared to the conditions during shield volcanism. Thus, flexural bending and metasomatism of the Samoan lithosphere may have generated the voluminous and geochemically distinct Samoan rejuvenated lavas, implying the lithosphere may play an important role during this stage in non- Hawaiian hot spots.

  13. NASA Administrator Dan Goldin speaks at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA Administrator Daniel S. Goldin (right) addresses the audience at the Apollo 11 anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex, with seating under an unused Saturn V rocket like those that powered the Apollo launches . This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin 'Buzz' Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7.

  14. NASA Administrator Dan Goldin speaks at Apollo 11 anniversary banquet.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    NASA Administrator Daniel S. Goldin addresses the audience at the Apollo 11 anniversary banquet honoring the Apollo team, the people who made the entire lunar landing program possible. The banquet was held in the Apollo/Saturn V Center, part of the KSC Visitor Complex. This is the 30th anniversary of the Apollo 11 launch and moon landing, July 16 and July 20, 1969. Among the guests at the banquet were former Apollo astronauts are Neil A. Armstrong and Edwin 'Buzz' Aldrin who flew on Apollo 11, the launch of the first moon landing; Gene Cernan, who flew on Apollo 10 and 17 and was the last man to walk on the moon; and Walt Cunningham, who flew on Apollo 7.

  15. The efficacy, longevity, and safety of combined radiofrequency treatment and hyaluronic Acid filler for skin rejuvenation.

    PubMed

    Kim, Hyuk; Park, Kui Young; Choi, Sun Young; Koh, Hyun-Ju; Park, Sun-Young; Park, Won-Seok; Bae, Il-Hong; Kim, Beom Joon

    2014-08-01

    Recent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed. The present study was designed to examine the clinical and histologic effects of a new needle that incorporates an RF device for HA injections. A new intradermal needle RF device (INNOfill; Pacific Pharma, Korea) was assessed in the present study. In the animal arm, procollagen production was measured by using enzyme-linked immunosorbent assay, the filler volume was quantified by incorporating a dye with filler, and the filler distribution was assessed through the changes in tissue structure. In the human arm, the efficacy of the combination regimen was assessed by using the wrinkle severity rating scale (WSRS). In the animal study, RF treatment increased procollagen production in a time-dependent fashion. The total volume was significantly increased with the RF treatment when compared with the filler injections alone, and lasted for up to 7 weeks after treatment. Additionally, the filler distribution was reduced in animals treated with RF when compared with the untreated group. In the human study, the nasolabial folds of subjects treated with RF before filler injections exhibited a significantly greater change in the WSRS score from baseline when compared with the nasolabial folds treated with filler injections alone. A new device incorporating RF treatment before HA filler injection may represent a biocompatible and long-lasting advance in skin rejuvenation.

  16. Hyaluronic acid and its use as a "rejuvenation" agent in cosmetic dermatology.

    PubMed

    Andre, Pierre

    2004-12-01

    Since 1996, hyaluronic acid (HA) has been launched onto the market in Europe. Since then, different companies proposed their HAs. Biomatrix (NJ, USA) proposes an animal-derived HA (from rooster comb). Q-Med AB (Uppsala, Sweden) and LEA-DERM (Paris, France) are the main companies to have a nonanimal HA. HA is produced by bacterial fermentation from a specific strain of streptococci. HA has no species specificity and theoretically has no risk of allergy. No skin testing is necessary before injecting because HA is a biodegradable agent. To be utilized as a filler agent for improving wrinkles, scars, or increasing volumes, HA must be stabilized to obtain a sufficient half-life. Process of stabilization varies, according to each manufacturer. This explains the differences in longevity and in viscosity of the different products. Several HAs are suitable to fine lines, to deep wrinkles/folds, or to increase volume. A new indication for "rejuvenation" is injection into the superficial dermis and epidermis. The HA (stabilized or not) is not used to fill in but rather to hydrate and finally to rejuvenate the skin. This procedure must be repeated at intervals of a few weeks or months. If HA is the safest filler agent in cosmetic indications today, some rare side effects may appear and must be known to inform patients. Most of these complications are not severe and will disappear when the product is degraded.

  17. Rejuvenation of Gene Expression Pattern of Aged Human Skin by Broadband Light Treatment: A Pilot Study

    PubMed Central

    Chang, Anne Lynn S; Bitter, Patrick H; Qu, Kun; Lin, Meihong; Rapicavoli, Nicole A; Chang, Howard Y

    2013-01-01

    Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply 3′-end sequencing for expression quantification (“3-seq”) to discover the gene expression program associated with human photoaging and intrinsic skin aging (collectively termed “skin aging”), and the impact of broadband light (BBL) treatment. We find that skin aging was associated with a significantly altered expression level of 2,265 coding and noncoding RNAs, of which 1,293 became “rejuvenated” after BBL treatment; i.e., they became more similar to their expression level in youthful skin. Rejuvenated genes (RGs) included several known key regulators of organismal longevity and their proximal long noncoding RNAs. Skin aging is not associated with systematic changes in 3′-end mRNA processing. Hence, BBL treatment can restore gene expression pattern of photoaged and intrinsically aged human skin to resemble young skin. In addition, our data reveal, to our knowledge, a previously unreported set of targets that may lead to new insights into the human skin aging process. PMID:22931923

  18. [Structural fat grafting for rejuvenation of the dorsum of the hand].

    PubMed

    Giunta, R E; Eder, M; Machens, H-G; Müller, D F; Kovacs, L

    2010-04-01

    In parallel with aging, increasing skin laxity and subcutaneous atrophy occur in many regions of the human body. Apart from the most obvious facial region, where most aesthetic operations for rejuvenation are done, also the dorsum of the hand is continuously visible in daily life. This region exhibits skin laxity, subcutaneous atrophy and age-related pigmentations in a comparable manner to the face. Autologous transplantation of fatty tissue (structural fat grafting, lipofilling) enables subcutaneous regeneration by refilling the subcutaneous space and hence reducing some of the age-related degenerative process. This paper illustrates the special operative technique on the hand in the form of a case report. Furthermore, 3D surface laser scanning permits an objective evaluation of the permanent volume effect over time. In the presented case a volume effect of 69% of the injected volume was measured after 6 months follow-up time. This amount of injected tissue seems to be integrated as a graft and results in a reduction of subcutaneous atrophy in terms of a true regeneration. Structural fat grafting of the dorsum of the hand is thus a method of regenerative medicine. Together with other methods which reduce the age-related pigmentations, it plays a key role in our treatment concept for rejuvenation of the hand. (c) Georg Thieme Verlag KG Stuttgart-New York.

  19. Effects of Multipolar Radiofrequency and Pulsed Electromagnetic Field Treatment for Face and Neck Rejuvenation

    PubMed Central

    de Oliveira, Thais Cristina Ferraz; Rocha, Sheyla de Fatima Soares; Ramos, Daniel Gontijo; Ramos, Camila Gontijo; Carvalho, Michelle Vanessa dos Anjos

    2017-01-01

    Skin aging is a gradual process that leads to wrinkle formation, laxity, and overall changes in skin appearance. In recent years, the demands to noninvasive treatments for facial rejuvenation increased, along with a variety of technologies and devices, such as radiofrequency. The present study aimed to evaluate the clinical effects of a multipolar radiofrequency and pulsed electromagnetic field treatment for face and neck rejuvenation. Eleven patients with mild to moderate grades of photoaging underwent eight radiofrequency and pulsed electromagnetic field treatment sessions, once a week. Clinical photographs were taken before and a week after the end of the treatment, and improvement of facial skin parameters was evaluated by two different investigators. Significant improvement in skin laxity was observed in all eleven patients (100%). Improvement in facial contour was noted in 73% and 100% of patients when analyzed by investigators A and B, respectively. The score for overall improvement in skin condition was 3 ± 0.78 for investigator A and 3.6 ± 0.67 for investigator B. All patients were satisfied with the procedure and noted significant improvement in the skin. The combined multipolar radiofrequency and pulsed electromagnetic field device is effective and safe for treatment of aged skin in Brazilian patients. PMID:28373880

  20. Beneficial effects of pro-/antioxidant-based nutraceuticals in the skin rejuvenation techniques.

    PubMed

    de Luca, C; Deeva, I; Mikhal'Chik, E; Korkina, L

    2007-04-15

    Modern technologies of skin rejuvenation include many physical and chemical intervention tools--laser irradiation, oxygen and ozone therapy, chemical peels, plastic surgery operations--affecting by different mechanisms the sensitive physiological free radical/antioxidant balance in the skin. All these interventions induce from mild to severe tissue damage, providing beneficial biochemical stimuli for skin re-epithelization and rejuvenation. Paradoxically, free radical production in the course of tissue inflammation helps to combat free radical damage consequent to the ageing process. We have studied two animal models (experimental burn and trichloracetic peeling), reproducing on the Wistar rat the effects generated by the commonly practiced aesthetic medicine procedures of laser resurfacing and chemical peels, demonstrating that the severe oxidative stress induced both systemically and on skin can be modulated by the oral pre- and post treatment administration of specific nutraceutical formulations. Potent antioxidants (RRR-alpha-tocopherol, coenzyme Q10), enhancing antioxidant defences, coupled with mild pro-oxidants, enhancers of a specific immune defense (soy phospholipids, L-methionine), at the blood and the skin levels, proved in fact to be beneficial in vivo, on the rat, for skin healing, trophism and accelerated re-epithelization. Data obtained allow us to predict the possibility of innovative protocols for dermocosmetology, enabling successful lowering of the risk of permanent adverse effects, and prolonging the duration of the beneficial effects of dermocosmetologic procedures.

  1. Effects of the Nd:YAG 1320-nm laser on skin rejuvenation: clinical and histological correlations.

    PubMed

    El-Domyati, Moetaz; El-Ammawi, Tarek S; Medhat, Walid; Moawad, Osama; Mahoney, Mỹ G; Uitto, Jouni

    2011-06-01

    The neodymium:yttrium-aluminum-garnet (Nd:YAG) laser is a popular non-ablative treatment used for skin rejuvenation. The purpose of this prospective study was to evaluate the clinical effects, coupled with a quantitative assessment, of the histological changes in response to Nd:YAG 1320-nm laser treatment of periocular wrinkles. Six volunteers with Fitzpatrick skin types III and IV and Glogau class I-II wrinkles were subjected to 3 months of Nd:YAG 1320-nm treatment in the periocular area (six sessions at 2-week intervals). Volunteers were photographed, and skin biopsies were obtained at baseline as well as 3 and 6 months after the start of treatments. Quantitative evaluation of total elastin, newly synthesized tropoelastin, collagen types I, III and VII, and newly synthesized collagen was performed using a computerized morphometric analysis. A noticeable clinical and histological improvement was observed after Nd:YAG 1320-nm treatment. Collagen types I, III and VII, as well as newly synthesized collagen, together with tropoelastin showed a statistically significant increase in response to treatment, while the mean level of total elastin was significantly decreased after treatment. Our data suggest that Nd:YAG 1320 nm is an effective treatment for skin rejuvenation as it stimulates the repair processes, and reverses the clinical, as well as the histopathological, signs of skin aging.

  2. The Efficacy, Longevity, and Safety of Combined Radiofrequency Treatment and Hyaluronic Acid Filler for Skin Rejuvenation

    PubMed Central

    Kim, Hyuk; Park, Kui Young; Choi, Sun Young; Koh, Hyun-Ju; Park, Sun-Young; Park, Won-Seok; Bae, Il-Hong

    2014-01-01

    Background Recent advances in hyaluronic acid (HA) fillers and radiofrequency (RF) devices have been made in the context of skin rejuvenation and cosmetic surgery. Moreover, combination regimens with both techniques are currently being developed. Objective The present study was designed to examine the clinical and histologic effects of a new needle that incorporates an RF device for HA injections. Methods A new intradermal needle RF device (INNOfill; Pacific Pharma, Korea) was assessed in the present study. In the animal arm, procollagen production was measured by using enzyme-linked immunosorbent assay, the filler volume was quantified by incorporating a dye with filler, and the filler distribution was assessed through the changes in tissue structure. In the human arm, the efficacy of the combination regimen was assessed by using the wrinkle severity rating scale (WSRS). Results In the animal study, RF treatment increased procollagen production in a time-dependent fashion. The total volume was significantly increased with the RF treatment when compared with the filler injections alone, and lasted for up to 7 weeks after treatment. Additionally, the filler distribution was reduced in animals treated with RF when compared with the untreated group. In the human study, the nasolabial folds of subjects treated with RF before filler injections exhibited a significantly greater change in the WSRS score from baseline when compared with the nasolabial folds treated with filler injections alone. Conclusion A new device incorporating RF treatment before HA filler injection may represent a biocompatible and long-lasting advance in skin rejuvenation. PMID:25143672

  3. Platelet-rich plasma combined with fractional laser therapy for skin rejuvenation.

    PubMed

    Shin, Min-Kyung; Lee, Jong-Ho; Lee, Sang-Jun; Kim, Nack-In

    2012-04-01

    Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate wound healing and rejuvenate aging skin. The current study was conducted to determine whether there are additional effects of PRP combined with fractional laser therapy. Twenty-two Korean women underwent three sessions of fractional laser; 11 were treated with topical application of PRP combined with fractional laser. Evaluations were done at baseline and 1 month after the final treatment. The outcome assessments included subjective satisfaction scale; blinded clinical assessment; and the biophysical parameters of roughness, elasticity, skin hydration, and the erythema and melanin index. Biopsies were analyzed using hematoxylin and eosin, Masson-trichrome, and immunohistochemistry for matrix metalloproteinase-1. PRP combined with fractional laser increased subject satisfaction and skin elasticity and decreased the erythema index. PRP increased the length of the dermoepidermal junction, the amount of collagen, and the number of fibroblasts. PRP with fractional laser treatment is a good combination therapy for skin rejuvenation. Keratinocyte and fibroblast proliferation and collagen production can explain the capacity of PRP to increase dermal elasticity. © 2012 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

  4. Rejuvenation of Appalachian topography caused by subsidence-induced differential erosion

    NASA Astrophysics Data System (ADS)

    Liu, Lijun

    2014-07-01

    In ancient orogens, such as the Appalachian Mountains in the eastern United States, the difference between the high and low points--topographic relief--can continue to increase long after the tectonic forces that created the range have become inactive. Climatic forcing and mantle-induced dynamic uplift could drive formation of relief, but clear evidence is lacking in the Appalachian Mountains. Here I use a numerical simulation of dynamic topography in North America, combined with reconstructions of the sedimentation history from the Gulf of Mexico, to show that rejuvenation of topographic relief in the Appalachian Mountains since the Palaeogene period could have been caused by mantle-induced dynamic subsidence associated with sinking of the subducted Farallon slab. Specifically, I show that patterns of continental erosion and the eastward migration of sediment deposition centres in the Gulf of Mexico closely follow the locus of predicted dynamic subsidence. Furthermore, pulses of rapid sediment deposition in the Gulf of Mexico and western Atlantic correlate with enhanced erosion in the Appalachian Mountains during the Miocene epoch, caused by dynamic tilting of the continent. The model predicts that such subsidence-induced differential erosion caused flexural-isostatic adjustments of Appalachian topography that led to the development of 400 m of relief and more than 200 m of elevation. I propose that dynamically induced continental tilting may provide a mechanism for topographic rejuvenation in ancient orogens.

  5. The First Reactor [40th Anniversary Commemorative Edition].

    DOE R&D Accomplishments Database

    1982-12-01

    This updated and revised story of the first reactor, or 'pile,' commemorates the 40th anniversary of the first controlled, self-sustaining nuclear chain reaction created by mankind. Enrico Fermi and his team of scientists initiated the reaction on December 2, 1941, underneath the West Stands of Stagg Field at the University of Chicago. Firsthand accounts of the participants as well as postwar recollections by Enrico and Laura Fermi are included.

  6. United States Special Operations Command History, 15th Anniversary

    DTIC Science & Technology

    2002-04-01

    Anniversary 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6 . AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER... 6 Evolution of the Command . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .9...Representative Dan Daniel (D-VA), the – 3 – Senator William Cohen (R-ME) Rep. Dan Daniel (D-VA) Senator Sam Nunn (D-GA) chairman of the Readiness

  7. 70th Anniversary Collection for the Microbiology Society: Microbial Genomics

    PubMed Central

    Thomson, Nicholas

    2015-01-01

    In the context of the Microbiology Society's 70th anniversary celebration, Microbial Genomics (MGen) is the new baby of the Society's publishing family. Born on 15 July 2015, it is still in its infancy but already showing promising signs, and we have great hopes and expectations for the future. The journal captures a new and expanding area of research, one which is already having a major impact on research in microbiology, and has and continues to accelerate discoveries in the field. PMID:28348824

  8. The first reactor [40th anniversary commemorative edition

    SciTech Connect

    1982-12-01

    This updated and revised story of the first reactor, or 'pile,' commemorates the 40th anniversary of the first controlled, self-sustaining nuclear chain reaction created by mankind. Enrico Fermi and his team of scientists initiated the reaction on December 2, 1941, underneath the West Stands of Stagg Field at the University of Chicago. Firsthand accounts of the participants as well as postwar recollections by Enrico and Laura Fermi are included.

  9. Telstar Anniversary Reminds Us How Far Space Weather Has Come

    NASA Astrophysics Data System (ADS)

    Lanzerotti, Louis J.

    2012-08-01

    The 50th anniversary of the launch of the first active communications satellite, the Telstar satellite, was marked 10 July 2012. The successful operation of Telstar during its almost 6-month life registered several firsts, as emphasized by President John F. Kennedy in an announcement that also bore evidence of the central role played by the Cold War in U.S. foreign policy at the beginning of the space age.

  10. Preface - 60th Anniversary of the Japanese Society for Neurochemistry.

    PubMed

    Imaizumi, Kazunori

    2017-02-15

    To welcome the 60th anniversary of the Japanese Society for Neurochemistry, in this issue, we publish five Review articles from the society's leading groups in the Journal of Neurochemistry, and introduce what we have achieved in the neurochemical fields of research, including Ca2+ neurobiology, synaptic plasticity, neurogenesis and neuroregeneration. With the achievements in the past decades in mind, we will continue to contribute to the development of neurochemistry from now on too. This article is protected by copyright. All rights reserved.

  11. NASA-marks 5th anniversary of first lunar landing

    NASA Technical Reports Server (NTRS)

    1974-01-01

    The accomplishments of the Apollo 11 Flight are presented as a tribute to the fifth anniversary of the first landing on the moon. The document contains: (1) a general description of the Apollo 11 Flight, (2) Presidential statements, (3) Apollo historical summary, (4) Apollo mission facts, (5) information on astronauts who are no longer in the program, and (6) transcripts of the landing sequence and first extravehicular activities on the moon.

  12. SeaWiFS Third Anniversary Global Biosphere

    NASA Technical Reports Server (NTRS)

    2002-01-01

    September 18,2000 is the third anniversary of the start of regular SeaWiFS operations of this remarkable planet called Earth. This SeaWiFS image is of the Global Biosphere depicting the ocean's long-term average phytoplankton chlorophyll concentration acquired between September 1997 and August 2000 combined with the SeaWiFS-derived Normalized Difference Vegetation Index (NDVI) over land during July 2000.

  13. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    Dr. Harriet Jenkins, Former Assistant Administrator for Equal Opportunity Programs at NASA, speaks as part of a panel discussion at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  14. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    Suzanne Malveaux, a correspondent with CNN, serves as a moderator at a panel discussion as part of an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  15. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    NASA Administrator Charles Bolden speaks at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. Administrator Bolden provided the opening remarks at the event and a tribute to the NASA civil rights team as the agency highlights the influence of the Civil Rights Act of 1964. Photo Credit: (NASA/Joel Kowsky)

  16. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    U.S. Representative Eddie Bernice Johnson, of Texas, left; answers a question from the audience during a panel discussion at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  17. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    U.S. Representative Eddie Bernice Johnson, of Texas, speaks as part of a panel discussion at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  18. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    Dr. Harriet Jenkins, Former Assistant Administrator for Equal Opportunity Programs at NASA, center; speaks as part of a panel discussion at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  19. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    Members of the audience listen as Dr. Michael Eric Dyson, a professor of sociology at Georgetown University, answers a question during a panel discussion at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  20. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    Dr. Roger Launius, Associate Director of Collections and Curatorial Affairs at the Smithsonian National Air and Space Museum, center; speaks as part of a panel discussion at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  1. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    Dr. Michael Eric Dyson, a professor of sociology at Georgetown University, speaks as part of a panel discussion at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  2. 50th Anniversary of the Civil Rights Act of 1964

    NASA Image and Video Library

    2014-06-23

    Dr. Roger Launius, Associate Director of Collections and Curatorial Affairs at the Smithsonian National Air and Space Museum, second from right, speaks as part of a panel discussion at an event celebrating the 50th Anniversary of the Civil Rights Act of 1964 on Monday, June 23, 2014 in the James E. Webb Auditorium at NASA Headquarters in Washington, DC. The event highlighted the influence of the Civil Rights Act on NASA. Photo Credit: (NASA/Joel Kowsky)

  3. ESO's First Observatory Celebrates 40th Anniversary

    NASA Astrophysics Data System (ADS)

    2009-03-01

    ESO's La Silla Observatory, which is celebrating its 40th anniversary, became the largest astronomical observatory of its time. It led Europe to the frontline of astronomical research, and is still one of the most scientifically productive in ground-based astronomy. ESO PR Photo 12a/09 La Silla Aerial View ESO PR Photo 12b/09 The ESO New Technology Telescope ESO PR Photo 12c/09 SEST on La Silla ESO PR Photo 12d/09 Looking for the best site ESO PR Video 12a/09 ESOcast 5 With about 300 refereed publications attributable to the work of the observatory per year, La Silla remains at the forefront of astronomy. It has led to an enormous number of scientific discoveries, including several "firsts". The HARPS spectrograph is the world's foremost exoplanet hunter. It detected the system around Gliese 581, which contains what may be the first known rocky planet in a habitable zone, outside the Solar System (ESO 22/07). Several telescopes at La Silla played a crucial role in discovering that the expansion of the Universe is accelerating (ESO 21/98) and in linking gamma-ray bursts -- the most energetic explosions in the Universe since the Big Bang - with the explosions of massive stars (ESO 15/98). Since 1987, the ESO La Silla Observatory has also played an important role in the study and follow-up of the nearest supernova, SN 1987A (ESO 08/07). "The La Silla Observatory continues to offer the astronomical community exceptional capabilities," says ESO Director General, Tim de Zeeuw. "It was ESO's first presence in Chile and as such, it triggered a very long and fruitful collaboration with this country and its scientific community." The La Silla Observatory is located at the edge of the Chilean Atacama Desert, one of the driest and loneliest areas of the world. Like other observatories in this geographical area, La Silla is located far from sources of polluting light and, as the Paranal Observatory that houses the Very Large Telescope, it has one of the darkest and clearest

  4. Submarine Rejuvenated-Stage Lavas Offshore Molokai, Oahu, Kauai, and Niihau, Hawaii

    NASA Astrophysics Data System (ADS)

    Clague, D. A.; Cousens, B. L.; Davis, A. S.; Dixon, J. E.; Hon, K.; Moore, J. G.; Reynolds, J. R.

    2003-12-01

    Rejuvenated-stage lavas from the Hawaiian Islands form many distinctive landmarks, such as Diamond Head. They have been relatively well studied due to their primitive, strongly alkaline compositions (alkalic basalt, basanite, nephelinite, melilitite, phonolite). More recently, compositionally similar lavas have been mapped and sampled on the deep seafloor around the islands. Rejuvenated-stage cones also occur on the submarine flanks of the islands. A Pisces V submersible dive collected samples from the only submarine cone on the north slope of East Molokai. The alkalic basalt to basanite composition lava is similar to the subaerial Kalaupapa basalt (Clague and Moore, 2003). MBARI Tiburon ROV dives recovered nephelinite from a lone steep cone on the northeast slope of Oahu, alkalic basalt from two shallow steep cones just west of the Koko Rift, and alkalic basalt from the submarine flank of Diamond Head on Oahu's south flank. These lavas are generally similar to subaerial Honolulu Volcanics, although the isotopic data extend to higher Sr isotopic values. Other MBARI Tiburon ROV dives recovered alkalic basalt and basanite from 8 separate steep cones on the south flank of Kauai. Once again, these lavas are chemically similar to those from the subaerial Koloa Volcanics. Samples from one of these cones contained common xenoliths of upper mantle lherzolite and harzburgite. Seven MBARI Tiburon ROV dives on the northwest flank of Niihau sampled 6 flat-topped cones and 5 pointed cones. The lavas from the flat-topped cones are alkalic basalt similar to rejuvenated Kiekie Basalt on Niihau Island whereas the lavas from the pointed cones are basanite, hawaiite, and tephrophonolite that are chemically distinct from the Kiekie Basalt, but similar to rejuvenated-stage lavas on Kauai and Oahu. Volcaniclastic deposits were observed and sampled at many of the sites offshore Niihau, Kauai, and Oahu, as well as the North Arch. Breadcrust and spindle bombs and spatter were found

  5. The 50th Anniversary IMIA History of Medical Informatics Project

    PubMed Central

    A. Kulikowski, Casimir

    2014-01-01

    At the meeting of the IMIA Board in 2009 in Hiroshima, it approved an IMIA 50th Anniversary History Project to produce a historical volume and other materials to commemorate the anniversary of the foundation of the predecessor of IMIA–the IFIP-TC4 in 1967. A Taskforce was organized under the direction of Casimir Kulikowski, then the VP for Services of IMIA, and since that time it has met regularly to plan and implement the 50th Anniversary History of IMIA as an edited volume, and as material available online on a Media Presentation Database. The IMIA Taskforce is gathering IMIA-related archival materials, currently accessible through a prototype media repository at Rutgers University in order to help those contributing to the book or writing their own recollections and histories. The materials will support a chronicle of the development and evolution of IMIA, its contributors, its sponsored events and publications, educational and other professional activities. During 2013 Workshops were held at the Prague EFMI-STC meeting in April and at the MEDINFO 2013 Congress in Copenhagen in August. PMID:24648622

  6. The 50(th) Anniversary IMIA History of Medical Informatics Project.

    PubMed

    Kulikowski, Casimir A

    2014-02-01

    At the meeting of the IMIA Board in 2009 in Hiroshima, it approved an IMIA 50th Anniversary History Project to produce a historical volume and other materials to commemorate the anniversary of the foundation of the predecessor of IMIA-the IFIP-TC4 in 1967. A Taskforce was organized under the direction of Casimir Kulikowski, then the VP for Services of IMIA, and since that time it has met regularly to plan and implement the 50th Anniversary History of IMIA as an edited volume, and as material available online on a Media Presentation Database. The IMIA Taskforce is gathering IMIA-related archival materials, currently accessible through a prototype media repository at Rutgers University in order to help those contributing to the book or writing their own recollections and histories. The materials will support a chronicle of the development and evolution of IMIA, its contributors, its sponsored events and publications, educational and other professional activities. During 2013 Workshops were held at the Prague EFMI-STC meeting in April and at the MEDINFO 2013 Congress in Copenhagen in August.

  7. DETAILED INVESTIGATION OF THE REJUVENATION OF A SPENT ELECTROLESS NICKEL SOLUTION BY ELECTRODIALYSIS WITH A VIEW TO OPTIMIZING ELECTRODIALYSIS PERFORMANCE

    EPA Science Inventory

    The rejuvenation of spent electroless nickel baths by electrodialysis has received a considerable amount of attention over the past decade and the technique is being increasingly employed to extend electroless nickel bath life. However, thus far there has not been a detailed inve...

  8. DETAILED INVESTIGATION OF THE REJUVENATION OF A SPENT ELECTROLESS NICKEL SOLUTION BY ELECTRODIALYSIS WITH A VIEW TO OPTIMIZING ELECTRODIALYSIS PERFORMANCE

    EPA Science Inventory

    The rejuvenation of spent electroless nickel baths by electrodialysis has received a considerable amount of attention over the past decade and the technique is being increasingly employed to extend electroless nickel bath life. However, thus far there has not been a detailed inve...

  9. Changes of the transverse diameter and volume and dosimetry before the 25th fraction during the course of intensity-modulated radiation therapy (IMRT) for patients with nasopharyngeal carcinoma

    SciTech Connect

    Yang Haihua; Hu Wei; Ding Weijun; Shan Guoping; Wang Wei; Yu Changhui; Wang Biyun; Shao Minghai; Wang Jianhua; Yang Weifang

    2012-07-01

    To quantify changes of the transverse diameter and volume and dosimetry, and to illustrate the inferiority of non-replanning during intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC) patients. Fifty-three NPC patients who received IMRT in 33 fractions were enrolled in this prospective trial. Before the 25th fraction, a new simulation computed tomography (CT) scan was acquired for all patients. The dose-volume histograms of the phantom plan were compared with the initial plan. Significant reduction of the transverse diameter of the nasopharyngeal, the neck, and 2 parotid glands volume was observed on second CT compared with the first CT (mean reduction 7.48 {+-} 4.45 mm, 6.80 {+-} 15.14 mm, 5.70 {+-} 6.26 mL, and 5.04 {+-} 5.85 mL, respectively; p < 0.01). The maximum dose and V-40 of the spinal cord, mean dose, and V30 of the left and right parotid, and V-50 of the brain stem were increased significantly in the phantom plan compared with the initial plan (mean increase 4.75 {+-} 5.55 Gy, 7.18 {+-} 10.07%, 4.51 {+-} 8.55 Gy, 6.59 {+-} 17.82%, 5.33 {+-} 8.55 Gy, 11.68 {+-} 17.11% and 1.48 {+-} 3.67%, respectively; p < 0.01). On the basis of dose constraint criterion in the RTOG0225 protocol, the dose of the normal critical structures for 52.83% (28/53) of the phantom plans were out of limit compared with 1.89% (1/53) of the initial plans (p < 0.0001). Because of the significant change in anatomy and dose before the 25th fraction during IMRT, replanning should be necessary during IMRT with NPC.

  10. Age and petrology of alkalic postshield and rejuvenated-stage lava from Kauai, Hawaii

    USGS Publications Warehouse

    Clague, D.A.; Dalrymple, G.B.

    1988-01-01

    At the top of the Waimea Canyon Basalt on the island of Kauai, rare flows of alkalic postshield-stage hawaiite and mugearite overlie tholeiitic flows of the shield stage. These postshield-stage flows are 3.92 Ma and provide a younger limit for the age of the tholeiitic shield stage. The younger Koloa Volcanics consist of widespread alkalic rejuvenated-stage flows and vents of alkalic basalt, basanite, nephelinite, and nepheline melilitite that erupted between 3.65 and 0.52 Ma. All the flows older than 1.7 Ma occur in the west-northwestern half of the island and all the flows younger than 1.5 Ma occur in the east-southeastern half. The lithologies have no spatial or chronological pattern. The flows of the Koloa Volcanics are near-primary magmas generated by variable small degrees of partial melting of a compositionally heterogeneous garnet-bearing source that has about two-thirds the concentration of P2O5, rare-earth elements, and Sr of the source of the Honolulu Volcanics on the island of Oahu. The same lithology in the Koloa and Honolulu Volcanics is generated by similar degrees of partial melting of distinct source compositions. The lavas of the Koloa Volcanics can be generated by as little as 3 percent to as much as 17 percent partial melting for nepheline melilitite through alkalic basalt, respectively. Phases that remain in the residue of the Honolulu Volcanics, such as rutile and phlogopite, are exhausted during formation of the Koloa Volcanics at all but the smallest degrees of partial melting. The mantle source for Kauai lava becomes systematically more depleted in 87Sr/86Sr as the volcano evolves from the tholeiitic shield stage to the alkalic postshield stage to the alkalic rejuvenated stage: at the same time, the lavas become systematically more enriched in incompatible trace elements. On a shorter timescale, the lavas of the Koloa Volcanics display the same compositional trends, but at a lower rate of change. The source characteristics of the Koloa

  11. Localized rejuvenation of a crystal mush recorded in zircon temporal and compositional variation at the Lassen Volcanic Center, northern California.

    PubMed

    Klemetti, Erik W; Clynne, Michael A

    2014-01-01

    Zircon ages and trace element compositions from recent silicic eruptions in the Lassen Volcanic Center (LVC) allow for an evaluation of the timing and conditions of rejuvenation (reheating and mobilization of crystals) within the LVC magmatic system. The LVC is the southernmost active Cascade volcano and, prior to the 1980 eruption of Mount St. Helens, was the site of the only eruption in the Cascade arc during the last century. The three most recent silicic eruptions from the LVC were very small to moderate-sized lava flows and domes of dacite (1915 and 27 ka eruptions of Lassen Peak) and rhyodacite (1.1 ka eruption of Chaos Crags). These eruptions produced mixed and mingled lavas that contain a diverse crystal cargo, including zircon. 238U-230Th model ages from interior and surface analyses of zircon reveal ages from ∼17 ka to secular equilibrium (>350 ka), with most zircon crystallizing during a period between ∼60-200 ka. These data support a model for localized rejuvenation of crystal mush beneath the LVC. This crystal mush evidently is the remnant of magmatism that ended ∼190 ka. Most zircon are thought to have been captured from "cold storage" in the crystal mush (670-725°C, Hf >10,000 ppm, Eu/Eu* 0.25-0.4) locally remobilized by intrusion of mafic magma. A smaller population of zircon (>730°C, Hf <10,000 ppm, Eu/Eu* >0.4) grew in, and are captured from, rejuvenation zones. These data suggest the dominant method to produce eruptible melt within the LVC is small-scale, local rejuvenation of the crystal mush accompanied by magma mixing and mingling. Based on zircon stability, the time required to heat, erupt and then cool to background conditions is relatively short, lasting a maximum of 10 s-1000 s years. Rejuvenation events in the LVC are ephemeral and permit eruption within an otherwise waning and cooling magmatic body.

  12. 3 CFR 8397 - Proclamation 8397 of July 23, 2009. 35th Anniversary of the Legal Services Corporation, 2009

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Proclamation 8397 of July 23, 2009. 35th Anniversary... Proclamation 8397 of July 23, 2009 Proc. 8397 35th Anniversary of the Legal Services Corporation, 2009By the... hereby proclaim July 25, 2009, as the 35th Anniversary of the Legal Services Corporation. I call upon...

  13. "Anniversary Reaction": Important Events and Timing of Death in a Group of Roman Catholic Priests.

    ERIC Educational Resources Information Center

    Walker, Lee; Walker, Lawrence D.

    1990-01-01

    Compared death dates of 1,038 Roman Catholic priests with dates of Christmas, Easter, birthday, and day of ordination. Found no meaningful patterns of death around any anniversary, suggesting either no association between time of death and important anniversaries or that important event may be so extraordinary to each individuals that it is not…

  14. 76 FR 33639 - Safety Zone; New York Water Taxi 10th Anniversary Fireworks

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-09

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; New York Water Taxi 10th Anniversary... to celebrate the 10th Anniversary of New York Water Taxi. The fireworks will commence at 9 p.m. on... CFR Part 165 Harbors, Marine safety, Navigation (water), Reporting and recordkeeping requirements...

  15. 77 FR 37326 - Safety Zone; Grand Hotel 125th Anniversary Fireworks Celebration, Mackinaw Island, MI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Grand Hotel 125th Anniversary Fireworks... launched from a point on Lake Huron to commemorate the Grand Hotel's 125th anniversary. The Captain of the Port, Sector Sault Sainte Marie, has determined that the Grand Hotel Celebration Fireworks Display will...

  16. EDITORIAL: STAM celebrates its 10th anniversary STAM celebrates its 10th anniversary

    NASA Astrophysics Data System (ADS)

    Ushioda, Sukekatsu

    2010-02-01

    I would like to extend my warmest greetings to the readers and staff of Science and Technology of Advanced Materials (STAM), on the occasion of its 10th anniversary. Launched in 2000, STAM marks this year an important milestone in its history. This is a great occasion to celebrate. STAM was founded by Tsuyoshi Masumoto in collaboration with Teruo Kishi and Toyonobu Yoshida as a world-class resource for the materials science community. It was initially supported by several materials research societies and was published as a regular peer-reviewed journal. Significant changes occurred in 2008, when the National Institute for Materials Science (NIMS) became solely responsible for all the costs of maintaining the journal. STAM was transformed into an open-access journal published by NIMS in partnership with IOP Publishing. As a result, the publication charges were waived and the entire STAM content, including all back issues, became freely accessible through the IOP Publishing website. The transition has made STAM more competitive and successful in global publication communities, with innovative ideas and approaches. The journal has also changed its publication strategy, aiming to publish a limited number of high-quality articles covering the frontiers of materials science. Special emphasis has been placed on reviews and focus issues, providing recent summaries of hot materials science topics. Publication has become electronic only; however, selected issues are printed and freely distributed at major international scientific events. The Editorial Board has been expanded to include leading experts from all over the world and, together with the Editorial Office, the board members are doing their best to transform STAM into a leading materials science journal. These efforts are paying off, as shown by the rapidly increasing number of article downloads and citations in 2009. I believe that the STAM audience can not only deepen their knowledge in their own specialties but

  17. Rejuvenation of the Innocent Bystander: Testing Spin-Up in Dwarf Carbon Stars

    NASA Astrophysics Data System (ADS)

    Green, Paul

    2013-09-01

    Carbon stars (C>O) were long assumed to all be giants, because only AGB stars dredge up significant carbon into their atmospheres. We now know that dwarf carbon (dC) stars are actually far more common than C giants. These dCs are hypothesized to have accreted C-rich envelope material from an AGB companion, in systems that have likely undergone a planetary nebula phase, eventually yielding a white dwarf and a dC that has gained both significant mass and angular momentum. To test whether the X-ray emission strength and spectral properties are consistent with a rejuvenated dynamo, we propose a Chandra pilot study of dCs selected from the SDSS; some have hot white dwarf companions (indicating more recent mass transfer), and all show Balmer emission lines (a sign of activity).

  18. Rejuvenation of the Innocent Bystander: Testing Spin-Up in a Dwarf Carbon Star Sample

    NASA Astrophysics Data System (ADS)

    Green, Paul

    2014-09-01

    Carbon stars (C>O) were long assumed to all be giants, because only AGB stars dredge up significant carbon into their atmospheres. We now know that dwarf carbon (dC) stars are actually far more common than C giants. These dC stars are hypothesized to have accreted C-rich envelope material from an AGB companion, in systems that have likely undergone a planetary nebula phase, eventually yielding a white dwarf and a dC star that has gained both significant mass and angular momentum. To test whether the X-ray emission strength and spectral properties are consistent with a rejuvenated dynamo, we propose a Chandra pilot study of dCs selected from the SDSS; some have hot white dwarf companions (indicating more recent mass transfer), and all show Balmer emission lines (a sign of activity).

  19. Phase separation dynamics in polymer blends close to Tg: aging and rejuvenating

    NASA Astrophysics Data System (ADS)

    Julien, Gregoire

    2013-03-01

    We extend the Percolation of Free Volume Distribution (PFVD) model developed by Long and co-workers to deal with polymer blends dynamics close to the glass transition. The dynamical model incorporates an extension of the Flory Huggins model to the case of compressible blends for calculating the driving forces. Spatial dynamics follows then from an Onsager like description. The model is solved on a 2D lattice corresponding to spatial scales of about a few tens to 100 nm and a resolution corresponding to the scale of dynamical heterogeneities, allowing to study phase separation close to Tg. We study also the reverse process, after the temperature is increased again in the totally miscible range. We observe a temporal asymmetry between the aging and the rejuvenation dynamics: the slow domains melt much faster than the elapsed time required to built them during the separation process and total miscibility is recovered after a much shorter time.

  20. Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction.

    PubMed

    Huang, Yanhua H; Schlüter, Oliver M; Dong, Yan

    2015-10-01

    A transient but prominent increase in the level of "silent synapses"--a signature of immature glutamatergic synapses that contain only NMDA receptors without stably expressed AMPA receptors--has been identified in the nucleus accumbens (NAc) following exposure to cocaine. As the NAc is a critical forebrain region implicated in forming addiction-associated behaviors, the initial discoveries have raised speculations about whether and how these drug-induced synapses mature and potentially contribute to addiction-related behaviors. Here, we summarize recent progress in recognizing the pathway-specific regulations of silent synapse maturation, and its diverse impacts on behavior. We provide an update of the guiding hypothesis--the "neural rejuvenation hypothesis"--with recently emerged evidence of silent synapses in cocaine craving and relapse. © The Author(s) 2015.

  1. Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction

    PubMed Central

    Huang, Yanhua H.; Schlüter, Oliver M.; Dong, Yan

    2015-01-01

    A transient but prominent increase in the level of “silent synapses”—a signature of immature glutamatergic synapses that contain only NMDA receptors without stably expressed AMPA receptors—has been identified in the nucleus accumbens (NAc) following exposure to cocaine. As the NAc is a critical forebrain region implicated in forming addiction-associated behaviors, the initial discoveries have raised speculations about whether and how these drug-induced synapses mature and potentially contribute to addiction-related behaviors. Here, we summarize recent progress in recognizing the pathway-specific regulations of silent synapse maturation, and its diverse impacts on behavior. We provide an update of the guiding hypothesis—the “neural rejuvenation hypothesis”—with recently emerged evidence of silent synapses in cocaine craving and relapse. PMID:25829364

  2. Selective dermal rejuvenation using intradermal injection of carbon dioxide and hyaluronic acid for facial wrinkles.

    PubMed

    Chin, Sae Hoon; Burm, Jin Sik; Kim, Youn Wha

    2013-06-01

    This study assessed selective dermal rejuvenation using sequential intradermal injections of carbon dioxide and hyaluronic acid as a treatment of facial wrinkles. An injection device was designed. After topical anesthesia, 0.1-mL carbon dioxide was gently injected intradermally so as to spread diffusely. A volume of 0.01- to 0.02-mL diluted hyaluronic acid was sequentially injected until the skin rose slightly. Overlapping injections were performed at 3 to 5 mm intervals. This process was repeated until the wrinkles were smoothened. This study included 36 cases of facial wrinkles in 34 patients. The follow-up period was 3 to 11 months. Temporary adverse effects were injection-site pain, mild edema, and redness. Most cases showed obvious improvement in skin thickness, elasticity, and smoothening. Complications included irregularities and hyperpigmentation in 3 cases, and 91% were highly satisfied with the antiwrinkle treatment. This method was a safe, economical, and clinically effective antiwrinkle treatment.

  3. Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug

    PubMed Central

    Marschallinger, Julia; Schäffner, Iris; Klein, Barbara; Gelfert, Renate; Rivera, Francisco J.; Illes, Sebastian; Grassner, Lukas; Janssen, Maximilian; Rotheneichner, Peter; Schmuckermair, Claudia; Coras, Roland; Boccazzi, Marta; Chishty, Mansoor; Lagler, Florian B.; Renic, Marija; Bauer, Hans-Christian; Singewald, Nicolas; Blümcke, Ingmar; Bogdahn, Ulrich; Couillard-Despres, Sebastien; Lie, D. Chichung; Abbracchio, Maria P.; Aigner, Ludwig

    2015-01-01

    As human life expectancy has improved rapidly in industrialized societies, age-related cognitive impairment presents an increasing challenge. Targeting histopathological processes that correlate with age-related cognitive declines, such as neuroinflammation, low levels of neurogenesis, disrupted blood–brain barrier and altered neuronal activity, might lead to structural and functional rejuvenation of the aged brain. Here we show that a 6-week treatment of young (4 months) and old (20 months) rats with montelukast, a marketed anti-asthmatic drug antagonizing leukotriene receptors, reduces neuroinflammation, elevates hippocampal neurogenesis and improves learning and memory in old animals. By using gene knockdown and knockout approaches, we demonstrate that the effect is mediated through inhibition of the GPR17 receptor. This work illustrates that inhibition of leukotriene receptor signalling might represent a safe and druggable target to restore cognitive functions in old individuals and paves the way for future clinical translation of leukotriene receptor inhibition for the treatment of dementias. PMID:26506265

  4. LATEST LASER AND LIGHT-BASED ADVANCES FOR ETHNIC SKIN REJUVENATION

    PubMed Central

    Elsaie, Mohamed Lotfy; Lloyd, Heather Woolery

    2008-01-01

    Background: Advances in nonablative skin rejuvenation technologies have sparked a renewed interest in the cosmetic treatment of aging skin. More options exist now than ever before to reverse cutaneous changes caused by long-term exposure to sunlight. Although Caucasian skin is more prone to ultraviolet light injury, ethnic skin (typically classified as types IV to VI) also exhibits characteristic photoaging changes. Widespread belief that inevitable or irreversible textural changes or dyspigmentation occurs following laser- or light-based treatments, has been challenged in recent years by new classes of devices capable of protecting the epidermis from injury during treatment. Objective: The purpose of this article is to review recent clinical advances in the treatment of photoaging changes in ethnic skin. This article provides a basis for the classification of current advances in nonablative management of ethnic skin. PMID:19881986

  5. The practicality or otherwise of biomedical rejuvenation therapies: a response to Kyriazis.

    PubMed

    de Grey, Aubrey D N J

    2014-08-01

    Elsewhere in this issue, Marios Kyriazis articulates a sharply skeptical assessment of the feasibility of medical rejuvenation, otherwise known as the "damage repair" approach to postponing the ill health of old age. His critique incorporates many errors of fact and/or interpretation and/or logic, which I enumerate here. I recognize that many of these errors are by no means Kyriazis's alone but are shared by numerous observers across the full range of biological expertise. It is for that reason above all that I hope this exchange will be of value to readers. Additionally, Kyriazis raises a number of valid concerns that have not been systematically addressed, by myself or by others, in past publications; I will attempt to remedy that here. For clarity, I will not structure this response as an essay, but instead as a simple point-by-point list of comments concerning individual statements and inferences that Kyriazis makes.

  6. Rejuvenation of MPTP-induced human neural precursor cell senescence by activating autophagy

    SciTech Connect

    Zhu, Liang; Dong, Chuanming; Sun, Chenxi; Ma, Rongjie; Yang, Danjing; Zhu, Hongwen; Xu, Jun

    2015-08-21

    Aging of neural stem cell, which can affect brain homeostasis, may be caused by many cellular mechanisms. Autophagy dysfunction was found in aged and neurodegenerative brains. However, little is known about the relationship between autophagy and human neural stem cell (hNSC) aging. The present study used 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) to treat neural precursor cells (NPCs) derived from human embryonic stem cell (hESC) line H9 and investigate related molecular mechanisms involved in this process. MPTP-treated NPCs were found to undergo premature senescence [determined by increased senescence-associated-β-galactosidase (SA-β-gal) activity, elevated intracellular reactive oxygen species level, and decreased proliferation] and were associated with impaired autophagy. Additionally, the cellular senescence phenotypes were manifested at the molecular level by a significant increase in p21 and p53 expression, a decrease in SOD2 expression, and a decrease in expression of some key autophagy-related genes such as Atg5, Atg7, Atg12, and Beclin 1. Furthermore, we found that the senescence-like phenotype of MPTP-treated hNPCs was rejuvenated through treatment with a well-known autophagy enhancer rapamycin, which was blocked by suppression of essential autophagy gene Beclin 1. Taken together, these findings reveal the critical role of autophagy in the process of hNSC aging, and this process can be reversed by activating autophagy. - Highlights: • We successfully establish hESC-derived neural precursor cells. • MPTP treatment induced senescence-like state in hESC-derived NPCs. • MPTP treatment induced impaired autophagy of hESC-derived NPCs. • MPTP-induced hESC-derived NPC senescence was rejuvenated by activating autophagy.

  7. Rejuvenation of shallow-crustal silicic magma bodies at Augustine and Hayes volcanoes, Alaska

    NASA Astrophysics Data System (ADS)

    Coombs, M. L.; Vazquez, J. A.; Hayden, L. A.; Calvert, A. T.; Lidzbarski, M. I.; Andersen, N. L.; Till, C. B.

    2015-12-01

    Rejuvenation of crystal-rich magma bodies leading to eruption can occur on a variety of scales and in varied tectonic settings. Two examples from the Aleutian arc highlight 1) segregation of silicic melt from an intermediate mush, and 2) "defrosting" of a shallowly emplaced intrusion. Augustine Volcano erupted a late Pleistocene rhyolite pumice fall that we link through zircon geochronology to cumulate dioritic blocks, ripped from Augustine's shallow magmatic plumbing system and ejected during the 2006 eruption. Unpolished zircon rims from the rhyolite yield a U-Th age of ~25 ka, and interiors yield a dominant age population of ~26 ka. Zircons from diorites have interior ages and compositions indistinguishable from those of the rhyolite. The diorites, rhyolite, and early Holocene dacites define whole-rock linear unmixing trends consistent with melt (rhyolite) extraction from a mush (dacites), leaving behind a cumulate residue (diorites). A volatile-rich basalt erupted just prior to the rhyolite likely facilitated melt extraction from the mush. The rhyolitic Hayes River ignimbrite, erupted from Hayes volcano, contains dense porphyry blocks that match pumices in composition and phenocryst content and are samples of a shallow intrusion. Autocrystic monazite accommodated up to several weight % Th and significantly affected the U-Th ratio of the magma during differentiation. An isochron for early melt and low-U monazites yields an age of ~67 ka, whereas one for late melt and high-U monazites yields ~42 ka. This younger age is indistinguishable from the laser single crystal Ar-Ar age for sanidine of 41±2 ka (1 sigma). We interpret the apparent ~25 k.y. crystallization interval to represent the assembly and differentiation timescale associated with the Hayes magma body. Sharp reverse zoning in sanidine from pumice (but not porphyry) records a thermal pulse not seen in the more slowly reacting phases, suggesting that a rejuvenation event occurred just prior to eruption.

  8. Towards cultural materialism in the medical humanities: the case of blood rejuvenation.

    PubMed

    Oakley, Catherine

    2017-05-11

    This paper argues for an approach within the medical humanities that draws on the theoretical legacy of cultural materialism as a framework for reading cultural practices and their relationship to the social and economic order. It revisits the origins and development of cultural materialism in cultural studies and literary studies between the 1970s and 1990s and considers how, with adaptation, this methodology might facilitate ideological criticism focused on material formations of health, disease and the human body. I outline three key characteristics of a medicocultural materialist approach along these lines: (a) interdisciplinary work on a broad range of medical and cultural sources, including those drawn from 'popular' forms of culture; (b) the combination of historicist analysis with scrutiny of present-day contexts; (c) analyses that engage with political economy perspectives and/or the work of medical sociology in this area. The subsequent sections of the paper employ a medicocultural materialist approach to examine conjectural understandings of, and empirical investigations into, the capacity of transfused human blood to rejuvenate the ageing body. I trace textual faultlines that expose the structures of power which inform the movement of blood between bodies in 'medical gothic' fictions from the 19th-century fin de siècle, including Mary Elizabeth Braddon's 'Good Lady Ducayne' (1896) and Bram Stoker's Dracula (1897). I conclude with a critique of biomedical innovations in blood rejuvenation in the era of medical neoliberalism, before considering the potential applications of medicocultural materialism to other topics within the field of the medical humanities. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  9. Petrologic evidence for thermal rejuvenation of crystal mush in the Bandelier Tuff

    NASA Astrophysics Data System (ADS)

    Wolff, J. A.; Wark, D. A.; Ramos, F. C.; Olin, P. H.

    2006-12-01

    The 1.6 Ma Otowi Member of the Bandelier Tuff consists of ~500 km3 of mineralogically, chemically and isotopically zoned high-silica rhyolite. The melt phase was saturated with trace amounts of zircon, chevkinite, britholite and allanite, and upward whole-pumice elemental enrichments and depletions in the tuff are predicted by crystallization-differentiation involving an assemblage bearing those minerals. Isotopic variations among glasses and feldspars have previously been attributed to roof-rock contamination (Wolff & Ramos, 2003), but new LA-ICPMS, ion probe and CL investigations of late-erupted glomerocryst-bearing pumice clasts indicate an additional role for magmatic recharge and thermal rejuvenation in affecting chemical gradients. First, trace element covariations in glasses at the submillimeter scale are distinct from those of whole pumices and require preferential non-modal melting of the trace phases. Second, Ti geothermometry of strongly CL-zoned quartz in glomerocrysts from the last-erupted products indicates an episode of partial quartz dissolution followed by higher-temperature regrowth. Third, this regrowth episode is also recorded among accompanying feldspar grains, which have rims enriched in Sr and Ba and with Pb isotope ratios distinct from crystal cores. These observations are consistent with a model in which an initially stratified magma body consisting of crystal-poor, highly differentiated rhyolite was underlain by cognate crystal mush residue, now represented by glomerocrysts. This body was disturbed by recharge and melting of the mush, with accompanying melt transfer, partial mingling of magma layers and roof-rock contamination, followed by an episode of recrystallization. Evidence that this recharge took place shortly before eruption (see abstract by Wark and Wolff) suggests that some of the observed zoning in the Bandelier Tuff, and possibly the eruption itself, occurred in response to chamber-wide thermal rejuvenation of a stagnant

  10. Ear Lobule Rejuvenation in Face-Lifting: The Role of Fat Augmentation

    PubMed Central

    Hammoudeh, Ziyad S.; Small, Kevin; Unger, Jacob G.; Stark, Ran

    2016-01-01

    Background: Ear lobule ptosis and deflation are characteristics of facial aging. A rhytidectomy without rejuvenation of a deflated ear lobule may fail to address all aspects of facial aging. Fillers have been used to treat ear lobule deflation; however, autologous fat transfer has never been utilized for ear lobule rejuvenation. This investigation studies the success of autologous fat transfer to the ear lobule as part of volume augmentation rhytidectomy. Methods: A retrospective review of patients who underwent rhytidectomy between 2000 and 2014 by a single surgeon was performed. Patients between 2000 and 2004 who did not receive autologous fat transfer served as controls (group A). Patients between 2010 and 2014 who received autologous fat transfer to the ear lobule formed the treatment group (group B). Three independent observers reviewed preoperative and postoperative photographs for both groups at 1 year postoperatively. The following ear lobule volume grading scale was applied to numerically assess the patients: concave = 0, flat = 1, convex = 2, and round = 3. Results: Groups A and B each consisted of 65 consecutive patients (130 ears). In group A, the mean preoperative ear lobule grading score was 1.20, and the mean postoperative score was 1.22 (mean difference, 0.02; P = 0.42). In group B, the mean preoperative ear lobule grading score was 0.98, and the mean postoperative score was 2.00 (mean difference, 1.02; P < 0.0001). Conclusion: In patients receiving autologous fat transfer to the ear lobule during rhytidectomy, there was a significant change from a deflated ear lobule preoperatively to a more voluminous lobule at 1 year postoperatively. PMID:27104096

  11. Rejuvenating harm reduction projects for injection drug users: Ukraine's nationwide introduction of peer-driven interventions.

    PubMed

    Smyrnov, Pavlo; Broadhead, Robert S; Datsenko, Oleksandra; Matiyash, Oksana

    2012-03-01

    A peer-driven intervention (PDI) for injecting drug users (IDUs) was implemented in five Ukrainian city-sites to test-pilot its effectiveness in rejuvenating harm reduction (HR) projects that had become moribund. A PDI relies on drug users in a unique way to educate their peers in the community and recruit them for HIV prevention services. The goal of the PDI was to recruit in six month 500 IDUs who had never been respondents before to each of the five HR projects, especially stimulant- and women-injectors, and IDUs<25 years of age. We standardized the PDI's structure and operations across all five sites. All five PDIs were started in May 2007 using a carefully selected handful of "seed" IDU-recruiters who were trained to educate three peers who had never received HR services. We also accessed the database of all five projects and analysed the new respondents they recruited six-months prior to the start-up of the PDIs with the new recruits generated by the PDIs. Whilst the HR projects in the five city-sites recruited 72 new respondents on average during the six months prior to the PDIs' start-up, the PDIs recruited 455 new respondents on average in each city during their six months of operation, indicating that the PDI was 6.3 times more powerful as a recruitment mechanism. Compared to traditional outreach the PDIs resulted in significant increases in the recruitment of women- and young-injectors, and IDUs who injected a more diverse variety of drugs. The PDI can have a rejuvenating effect when added to HR projects that had become stagnate over time, resulting in an increase in the number and diversity of new IDU-respondents. Copyright © 2012 Elsevier B.V. All rights reserved.

  12. [Fractional photo-thermolysis by laser Fraxel as an adjuvant for facial surgical rejuvenation].

    PubMed

    Buis, J; Mazer, J-M

    2007-06-01

    The fractional resurfacing (Fraxel laser) is a new procedure for facial and extrafacial rejuvenation. His claim is obtain a great efficacy on wrinkles, close to those of the CO(2) and erbium lasers, but without their risks and long lasting down time. We use a scanner, able to create multiple (around 2000 to 3000/cm(2)) 70-150 microns diameter microthermal zones surrounded by islands of viable tissue. The reepithelialization is complete in a day, but there is a collagen denaturization in the dermis, between 300-750 microns like after a traditional resurfacing. At each session, around 25% of the dermis are treated. 4 treatments are performed with a 1 to 2 weeks interval. We report our comprehensive results since we began in December 2004. At the time of the abstract, 600 sessions were performed (150 Patients). A visible reduction of wrinkles is observed anytime, with improvement of the texture of the skin, and in the same time, a dramatic improvement of the pigmented lesions. About tolerance, no severe side effects or dyschromia were noticed. We observed two case of limited erosion, (one of the first patients) due to a practical problem (bulk heating). The average erythema duration is 2 days. On the face, a 2-4 days edema occurs in many of the patients. Fraxel laser treatment is not designed as a substitute for surgical skin tightening such as facelift. Therefore, the fractional resurfacing is safe and effective for a visible reduction of wrinkles and appears as a very interesting treatment in association with face lift to rejuvenate the face.

  13. The 25th Aerospace Mechanisms Symposium

    NASA Technical Reports Server (NTRS)

    1991-01-01

    Twenty-two papers are documented regarding aeronautical and spacecraft hardware. Technological areas include actuators, latches, cryogenic mechanisms, vacuum tribology, bearings, robotics, ground support equipment for aerospace applications, and other mechanisms.

  14. 25th Test and Evaluation National Conference

    DTIC Science & Technology

    2009-03-05

    7.62MM Javelin (2) 3 3 PL/VC O2 19A Crew Chief E5 19K20 DR E4 19K10 CL I UAV Ch CL 1 UAS LCU C Provides BLOS support to Infantry Platoons Original analysis ...Vice President, SAIC THE ANALYSIS OF ALTERNATIVES (AOA): A MISSION-ORIENTED, EVALUATION-BASED FRAMEWORK FOR DEFENSE TEST & EVALUATION Mr. Vincent P...Decision Analysis Guiding System Reliability Growth Dr. Patricia Jacobs, Naval Postgraduate School 3:30 pm System of Systems – Survivability

  15. Peer assistance reaches its 25th year.

    PubMed

    Quinlan, Diana

    2009-08-01

    This column traces the history of the efforts of the American Association of Nurse Anesthetists to provide assistance to members struggling with addiction. The work of the Ad Hoc Committee on Chemical Dependency, the Peer Assistance Advisors, Anesthetists in Recovery, the Council on Public Interest in Anesthesia, and the Wellness Program are examined.

  16. Marking the 400th Anniversary of Kepler's Astronomia nova

    NASA Astrophysics Data System (ADS)

    Mahoney, T. J.

    2010-11-01

    Special Session 9 of the XXVII General Assembly (11-14 August 2009, Rio de Janeiro) was devoted to the topic “Marking the 400th Anniversary of Kepler's Astronomia nova”. During the two-and-a-half day meeting (spread over four days), there were nine invited and three contributed talks, a round-table discussion on the future of Kepler studies and an open session to propose the setting up of a Johannes Kepler Working Group under the aegis of the IAU.

  17. [The 90th anniversary of Novocherkassk military hospital].

    PubMed

    Benia, F M; Matsko, B G

    2010-02-01

    The article is devoted to the 90th anniversary of Novocherkassk military hospital of Northern Caucasus military region (Rostov area). Military hospital is a modern treatment-prophylaxis institute. Quality of treatment of military service men, members of their families, reserve officers, civil staff is permanently increasing. Treatment-diagnostic units are equipped by modern facilities. 60 physicians and nurses have highest and first qualified categories. More then 10 years the staff of hospital realizes the medical aid to wounded and ill persons, coming from theatres of the armed conflicts.

  18. Fifth anniversary of the first element of the International Spac

    NASA Image and Video Library

    2003-12-03

    Members of the media were invited to commemorate the fifth anniversary of the launch of the first element of the International Space Station by touring the Space Station Processing Facility (SSPF) at KSC. Here they gather around Shimpei Takahashi (back to camera), representative of the Japanese Air and Space Agency (JAXA), who talked about the Japanese Experiment Module. Reporters had the opportunity to see Space Station hardware that is being processed for deployment once the Space Shuttles return to flight as well as talk with NASA and Boeing mission managers about the various hardware elements currently being processed for flight.

  19. Fifth anniversary of the first element of the International Spac

    NASA Image and Video Library

    2003-12-03

    In the Space Station Processing Facility (SSPF), Mike Generale (background) talks to the media about the research racks behind him that will be used on missions to the International Space Station. To commemorate the fifth anniversary of the launch of the first element of the International Space Station, the media were invited to tour the SSPF at KSC. Reporters had the opportunity to see Space Station hardware that are being processed for deployment once the Space Shuttles return to flight as well as talk with NASA and Boeing mission managers about the various hardware elements currently being processed for flight.

  20. Fifth anniversary of the first element of the International Spac

    NASA Image and Video Library

    2003-12-03

    The Japanese Experiment Module or JEM (background) and other hardware undergoing processing for transport to the International Space Station are made available to photographers in the Space Station Processing Facility (SSPF). Members of the media were invited to commemorate the fifth anniversary of the launch of the first element of the International Space Station by touring the SSPF. Reporters had the opportunity to see Space Station hardware that is being processed for deployment once the Space Shuttles return to flight, as well as talk with NASA and Boeing mission managers about the various hardware elements currently being processed for flight.