Science.gov

Sample records for 2b1 turboshaft engines

  1. Computer Simulation Of A Small Turboshaft Engine

    NASA Technical Reports Server (NTRS)

    Ballin, Mark G.

    1991-01-01

    Component-type mathematical model of small turboshaft engine developed for use in real-time computer simulations of dynamics of helicopter flight. Yields shaft speeds, torques, fuel-consumption rates, and other operating parameters with sufficient accuracy for use in real-time simulation of maneuvers involving large transients in power and/or severe accelerations.

  2. 76 FR 70334 - Airworthiness Directives; Honeywell International Inc. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-14

    ... Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska... International Inc. Turboshaft Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule... International Inc. LTS101-600A-2, -3, -3A, and LTS101-700D-2 turboshaft engines with certain power...

  3. 77 FR 1009 - Airworthiness Directives; Turbomeca Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-09

    ... (76 FR 77378, December 13, 2011), currently requires removing from service certain gas generator...; AD 2010-19-06R1] RIN 2120-AA64 Airworthiness Directives; Turbomeca Turboshaft Engines AGENCY: Federal... series turboshaft engines. The AD number is incorrect in the preamble and in the Regulatory text....

  4. 78 FR 32551 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-31

    ...We are superseding an existing airworthiness directive (AD) for Turbomeca S.A. Arrius 2B, 2B1, and 2F turboshaft engines. That AD currently requires replacement of injector manifolds and borescope- inspection of the flame tube and the high-pressure (HP) turbine area for possible damage. This new AD requires, depending on the engine model, repetitive replacements of fuel injection manifolds and......

  5. Temperature distortion generator for turboshaft engine testing

    NASA Technical Reports Server (NTRS)

    Klann, G. A.; Barth, R. L.; Biesiadny, T. J.

    1984-01-01

    The procedures and unique hardware used to conduct an experimental investigation into the response of a small-turboshaft-engine compression system to various hot gas ingestion patterns are presented. The temperature distortion generator described herein uses gaseous hydrogen to create both steady-state and time-variant, or transient, temperature distortion at the engine inlet. The range of transient temperature ramps produced by the distortion generator during the engine tests was from less than 111 deg K/sec (200 deg R/sec) to above 611 deg K/sec (1100 deg R/sec); instantaneous temperatures to 422 deg K (760 deg R) above ambient were generated. The distortion generator was used to document the maximum inlet temperatures and temperature rise rates that the compression system could tolerate before the onset of stall for various circumferential distortions as well as the compressor system response during stall.

  6. A simplified dynamic model of the T700 turboshaft engine

    NASA Technical Reports Server (NTRS)

    Duyar, Ahmet; Gu, Zhen; Litt, Jonathan S.

    1992-01-01

    A simplified open-loop dynamic model of the T700 turboshaft engine, valid within the normal operating range of the engine, is developed. This model is obtained by linking linear state space models obtained at different engine operating points. Each linear model is developed from a detailed nonlinear engine simulation using a multivariable system identification and realization method. The simplified model may be used with a model-based real time diagnostic scheme for fault detection and diagnostics, as well as for open loop engine dynamics studies and closed loop control analysis utilizing a user generated control law.

  7. Infrared suppressor effect on T63 turboshaft engine performance

    NASA Technical Reports Server (NTRS)

    Bailey, E. E.; Civinskas, K. C.; Walker, C. L.

    1978-01-01

    Tests were conducted to determine if there are performance penalties associated with the installation of infrared (IR) suppressors on the T63-A-700 turboshaft engine. The testing was done in a sea-level, static test cell. The same engine (A-E402808 B) was run with the standard OH-58 aircraft exhaust stacks and with the ejector-type IR suppressors in order to make a valid comparison. Repeatability of the test results for the two configurations was verified by rerunning the conditions over a period of days. Test results showed no measurable difference in performance between the standard exhaust stacks and the IR suppressors.

  8. Dynamic Simulation of a Wave Rotor Topped Turboshaft Engine

    NASA Technical Reports Server (NTRS)

    Greendyke, R. B.; Paxson, D. E.; Schobeiri, M. T.

    1997-01-01

    The dynamic behavior of a wave rotor topped turboshaft engine is examined using a numerical simulation. The simulation utilizes an explicit, one-dimensional, multi-passage, CFD based wave rotor code in combination with an implicit, one-dimensional, component level dynamic engine simulation code. Transient responses to rapid fuel flow rate changes and compressor inlet pressure changes are simulated and compared with those of a similarly sized, untopped, turboshaft engine. Results indicate that the wave rotor topped engine responds in a stable, and rapid manner. Furthermore, during certain transient operations, the wave rotor actually tends to enhance engine stability. In particular, there is no tendency toward surge in the compressor of the wave rotor topped engine during rapid acceleration. In fact, the compressor actually moves slightly away from the surge line during this transient. This behavior is precisely the opposite to that of an untopped engine. The simulation is described. Issues associated with integrating CFD and component level codes are discussed. Results from several transient simulations are presented and discussed.

  9. 77 FR 32437 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-01

    ... different compliance time. We are proposing this AD to prevent rupture of a gas generator (GG) turbine blade...-13-05, Amendment 39-16728 (76 FR 40222, July 8, 2011) for Turbomeca S.A. Arriel 2B and 2B1 turboshaft... AD resulted from several cases of GG turbine blade rupture occurring in service on Arriel 2...

  10. 75 FR 5689 - Airworthiness Directives; Turbomeca Arriel 2B and 2B1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-04

    ... November 5, 2009 (74 FR 57277). That NPRM proposed to correct an unsafe condition for the specified... ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3... This AD and the MCAI or Service Information The MCAI requires checking the transmissible torque...

  11. 75 FR 30687 - Airworthiness Directives; Turbomeca Arriel 2B1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ... Register on March 22, 2010 (75 FR 13451). That NPRM proposed to correct an unsafe condition for the... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant... 2. The FAA amends Sec. 39.13 by removing amendment 39-15200 (72 FR 53112, September 18, 2007),...

  12. 75 FR 13451 - Airworthiness Directives; Turbomeca Arriel 2B1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-22

    ... Register published on April 11, 2000 (65 FR 19477-78). Examining the AD Docket You may examine the AD... September 11, 2007, the FAA issued AD 2007-19-09, Amendment 39- 15200 (72 FR 53112, September 18, 2007... Procedures (44 FR 11034, February 26, 1979); and 3. Would not have a significant economic impact, positive...

  13. Neural Network-Based Sensor Validation for Turboshaft Engines

    NASA Technical Reports Server (NTRS)

    Moller, James C.; Litt, Jonathan S.; Guo, Ten-Huei

    1998-01-01

    Sensor failure detection, isolation, and accommodation using a neural network approach is described. An auto-associative neural network is configured to perform dimensionality reduction on the sensor measurement vector and provide estimated sensor values. The sensor validation scheme is applied in a simulation of the T700 turboshaft engine in closed loop operation. Performance is evaluated based on the ability to detect faults correctly and maintain stable and responsive engine operation. The set of sensor outputs used for engine control forms the network input vector. Analytical redundancy is verified by training networks of successively smaller bottleneck layer sizes. Training data generation and strategy are discussed. The engine maintained stable behavior in the presence of sensor hard failures. With proper selection of fault determination thresholds, stability was maintained in the presence of sensor soft failures.

  14. Contingency power concepts for helicopter turboshaft engine

    NASA Technical Reports Server (NTRS)

    Hirschkron, R.; Davis, R. H.; Goldstein, D. N.; Haynes, J. F.; Gauntner, J. W.

    1984-01-01

    Twin helicopter engines are often sized by power requirement of safe mission completion after the failure of one of the two engines. This study was undertaken for NASA Lewis by General Electric Co. to evaluate the merits of special design features to provide a 2-1/2 minute Contingency Power rating, permitting an engine size reduction. The merits of water injection, cooling flow modulation, throttle push and an auxiliary power plant were evaluated using military life cycle cost (LCC) and commercial helicopter direct operating cost (DOC) merit factors in a rubber engine/rubber aircraft scenario.

  15. Automated Power Assessment for Helicopter Turboshaft Engines

    NASA Technical Reports Server (NTRS)

    Simon, Donald L.; Litt, Jonathan S.

    2008-01-01

    An accurate indication of available power is required for helicopter mission planning purposes. Available power is currently estimated on U.S. Army Blackhawk helicopters by performing a Maximum Power Check (MPC), a manual procedure performed by maintenance pilots on a periodic basis. The MPC establishes Engine Torque Factor (ETF), an indication of available power. It is desirable to replace the current manual MPC procedure with an automated approach that will enable continuous real-time assessment of available power utilizing normal mission data. This report presents an automated power assessment approach which processes data currently collected within helicopter Health and Usage Monitoring System (HUMS) units. The overall approach consists of: 1) a steady-state data filter which identifies and extracts steady-state operating points within HUMS data sets; 2) engine performance curve trend monitoring and updating; and 3) automated ETF calculation. The algorithm is coded in MATLAB (The MathWorks, Inc.) and currently runs on a PC. Results from the application of this technique to HUMS mission data collected from UH-60L aircraft equipped with T700-GE-701C engines are presented and compared to manually calculated ETF values. Potential future enhancements are discussed.

  16. The Case for Distributed Engine Control in Turbo-Shaft Engine Systems

    NASA Technical Reports Server (NTRS)

    Culley, Dennis E.; Paluszewski, Paul J.; Storey, William; Smith, Bert J.

    2009-01-01

    The turbo-shaft engine is an important propulsion system used to power vehicles on land, sea, and in the air. As the power plant for many high performance helicopters, the characteristics of the engine and control are critical to proper vehicle operation as well as being the main determinant to overall vehicle performance. When applied to vertical flight, important distinctions exist in the turbo-shaft engine control system due to the high degree of dynamic coupling between the engine and airframe and the affect on vehicle handling characteristics. In this study, the impact of engine control system architecture is explored relative to engine performance, weight, reliability, safety, and overall cost. Comparison of the impact of architecture on these metrics is investigated as the control system is modified from a legacy centralized structure to a more distributed configuration. A composite strawman system which is typical of turbo-shaft engines in the 1000 to 2000 hp class is described and used for comparison. The overall benefits of these changes to control system architecture are assessed. The availability of supporting technologies to achieve this evolution is also discussed.

  17. A high fidelity real-time simulation of a small turboshaft engine

    NASA Technical Reports Server (NTRS)

    Ballin, Mark G.

    1988-01-01

    A high-fidelity component-type model and real-time digital simulation of the General Electric T700-GE-700 turboshaft engine were developed for use with current generation real-time blade-element rotor helicopter simulations. A control system model based on the specification fuel control system used in the UH-60A Black Hawk helicopter is also presented. The modeling assumptions and real-time digital implementation methods particular to the simulation of small turboshaft engines are described. The validity of the simulation is demonstrated by comparison with analysis-oriented simulations developed by the manufacturer, available test data, and flight-test time histories.

  18. 77 FR 2015 - Special Conditions: Pratt and Whitney Canada Model PW210S Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 33 Special Conditions: Pratt and Whitney Canada Model PW210S Turboshaft Engine Correction In rule document 2011-14113 appearing on pages 33981-33982 in the issue...

  19. 78 FR 19982 - Special Conditions: Turbomeca Ardiden 3K Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-03

    ... turboshaft engine was published on November 8, 2012 (77 FR 66936). We received no comments. Applicability... definition, instructions for continued airworthiness (ICA), instrumentation, and endurance testing because... to address this design feature. The ICA requirement addresses the unknown nature of actual...

  20. 75 FR 22693 - Airworthiness Directives; Turbomeca Makila 2A Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-30

    ... Register published on April 11, 2000 (65 FR 19477-78). Authority for This Rulemaking Title 49 of the United... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... Turboshaft Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule; request...

  1. 78 FR 44897 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78). Discussion The... (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska to the extent that.... Turboshaft Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed...

  2. Fault Diagnostics for Turbo-Shaft Engine Sensors Based on a Simplified On-Board Model

    PubMed Central

    Lu, Feng; Huang, Jinquan; Xing, Yaodong

    2012-01-01

    Combining a simplified on-board turbo-shaft model with sensor fault diagnostic logic, a model-based sensor fault diagnosis method is proposed. The existing fault diagnosis method for turbo-shaft engine key sensors is mainly based on a double redundancies technique, and this can't be satisfied in some occasions as lack of judgment. The simplified on-board model provides the analytical third channel against which the dual channel measurements are compared, while the hardware redundancy will increase the structure complexity and weight. The simplified turbo-shaft model contains the gas generator model and the power turbine model with loads, this is built up via dynamic parameters method. Sensor fault detection, diagnosis (FDD) logic is designed, and two types of sensor failures, such as the step faults and the drift faults, are simulated. When the discrepancy among the triplex channels exceeds a tolerance level, the fault diagnosis logic determines the cause of the difference. Through this approach, the sensor fault diagnosis system achieves the objectives of anomaly detection, sensor fault diagnosis and redundancy recovery. Finally, experiments on this method are carried out on a turbo-shaft engine, and two types of faults under different channel combinations are presented. The experimental results show that the proposed method for sensor fault diagnostics is efficient. PMID:23112645

  3. Fault diagnostics for turbo-shaft engine sensors based on a simplified on-board model.

    PubMed

    Lu, Feng; Huang, Jinquan; Xing, Yaodong

    2012-01-01

    Combining a simplified on-board turbo-shaft model with sensor fault diagnostic logic, a model-based sensor fault diagnosis method is proposed. The existing fault diagnosis method for turbo-shaft engine key sensors is mainly based on a double redundancies technique, and this can't be satisfied in some occasions as lack of judgment. The simplified on-board model provides the analytical third channel against which the dual channel measurements are compared, while the hardware redundancy will increase the structure complexity and weight. The simplified turbo-shaft model contains the gas generator model and the power turbine model with loads, this is built up via dynamic parameters method. Sensor fault detection, diagnosis (FDD) logic is designed, and two types of sensor failures, such as the step faults and the drift faults, are simulated. When the discrepancy among the triplex channels exceeds a tolerance level, the fault diagnosis logic determines the cause of the difference. Through this approach, the sensor fault diagnosis system achieves the objectives of anomaly detection, sensor fault diagnosis and redundancy recovery. Finally, experiments on this method are carried out on a turbo-shaft engine, and two types of faults under different channel combinations are presented. The experimental results show that the proposed method for sensor fault diagnostics is efficient. PMID:23112645

  4. Boeing XF2B-1 (F2B-1)

    NASA Technical Reports Server (NTRS)

    1931-01-01

    Boeing XF2B-1 (F2B-1): Serving as the prototype for the F2B-1 shipboard fighter, the XF2B-1 differed visually in having a pointed spinner and an unbalanced rudder. Like many aircraft of its day, the Boeing model 69 was powered by a Pratt & Whitney Wasp radial engine.

  5. Simulating a small turboshaft engine in real-time multiprocessor simulator (RTMPS) environment

    NASA Technical Reports Server (NTRS)

    Milner, E. J.; Arpasi, D. J.

    1986-01-01

    A Real-Time Multiprocessor Simulator (RTMPS) has been developed at NASA Lewis Research Center. The RTMPS uses parallel microprocessors to achieve computing speeds needed for real-time engine simulation. This report describes the use of the RTMPS system to simulate a small turboshaft engine. The process of programming the engine equations and distributing them over one, two, and four processors is discussed. Steady-state and transient results from the RTMPS simulation are compared with results from a main-frame-based simulation. Processor execution times and the associated execution time savings for the two and four processor cases are presented using actual data obtained from the RTMPS system. Included is a discussion of why the minimum achievable calculation time for the turboshaft engine model was attained using four processors. Finally, future enhancements to the RTMPS system are discussed including the development of a generalized partitioning algorithm to automatically distribute the system equations among the processors in optimum fashion.

  6. Performance Benefits for a Turboshaft Engine Using Nonlinear Engine Control Technology Investigated

    NASA Technical Reports Server (NTRS)

    Jones, Scott M.

    2004-01-01

    The potential benefits of nonlinear engine control technology applied to a General Electric T700 helicopter engine were investigated. This technology is being developed by the U.S. Navy SPAWAR Systems Center for a variety of applications. When used as a means of active stability control, nonlinear engine control technology uses sensors and small amounts of injected air to allow compressors to operate with reduced stall margin, which can improve engine pressure ratio. The focus of this study was to determine the best achievable reduction in fuel consumption for the T700 turboshaft engine. A customer deck (computer code) was provided by General Electric to calculate the T700 engine performance, and the NASA Glenn Research Center used this code to perform the analysis. The results showed a 2- to 5-percent reduction in brake specific fuel consumption (BSFC) at the three Sikorsky H-60 helicopter operating points of cruise, loiter, and hover.

  7. 76 FR 77446 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... Turbomeca S.A. Arrius 2F turboshaft engines with P3 air pipe (first section) part number (P/N) 0 319 71 918... engines with P3 air pipe (first section), P/N 0 319 71 918 0, installed. That AD requires inspections of...) of this AD as follows: (i) At every installation of a RH rear half-wall P/N 0 319 99 824 0 on...

  8. A New Turbo-shaft Engine Control Law during Variable Rotor Speed Transient Process

    NASA Astrophysics Data System (ADS)

    Hua, Wei; Miao, Lizhen; Zhang, Haibo; Huang, Jinquan

    2015-12-01

    A closed-loop control law employing compressor guided vanes is firstly investigated to solve unacceptable fuel flow dynamic change in single fuel control for turbo-shaft engine here, especially for rotorcraft in variable rotor speed process. Based on an Augmented Linear Quadratic Regulator (ALQR) algorithm, a dual-input, single-output robust control scheme is proposed for a turbo-shaft engine, involving not only the closed loop adjustment of fuel flow but also that of compressor guided vanes. Furthermore, compared to single fuel control, some digital simulation cases using this new scheme about variable rotor speed have been implemented on the basis of an integrated system of helicopter and engine model. The results depict that the command tracking performance to the free turbine rotor speed can be asymptotically realized. Moreover, the fuel flow transient process has been significantly improved, and the fuel consumption has been dramatically cut down by more than 2% while keeping the helicopter level fight unchanged.

  9. 78 FR 11565 - Airworthiness Directives; Pratt & Whitney Canada Corp. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ...We are adopting a new airworthiness directive (AD) for certain serial number Pratt & Whitney Canada Corp. PW206B, PW206B2, PW206C, PW207C, PW207D, PW207D1, PW207D2, and PW207E turboshaft engines. This AD was prompted by the discovery that certain power turbine (PT) disks were made to specific heat codes that may not achieve the maximum in- service life. This AD requires re-identification of......

  10. Design description of a microprocessor based Engine Monitoring and Control unit (EMAC) for small turboshaft

    NASA Technical Reports Server (NTRS)

    Baez, A. N.

    1985-01-01

    Research programs have demonstrated that digital electronic controls are more suitable for advanced aircraft/rotorcraft turbine engine systems than hydromechanical controls. Commercially available microprocessors are believed to have the speed and computational capability required for implementing advanced digital control algorithms. Thus, it is desirable to demonstrate that off-the-shelf microprocessors are indeed capable of performing real time control of advanced gas turbine engines. The engine monitoring and control (EMAC) unit was designed and fabricated specifically to meet the requirements of an advanced gas turbine engine control system. The EMAC unit is fully operational in the Army/NASA small turboshaft engine digital research program.

  11. 76 FR 40222 - Airworthiness Directives; Turbomeca S.A. ARRIEL 2B and 2B1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-08

    ... describes the unsafe condition as: Several cases of Gas Generator (GG) Turbine Blade rupture occurred in... GG turbine blade, which could result in an uncommanded in-flight shutdown and an emergency... FR 9515). That NPRM proposed to correct an unsafe condition for the specified products. The...

  12. 76 FR 9515 - Airworthiness Directives; Turbomeca S.A. ARRIEL 2B and 2B1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-18

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... about 60 work-hours per product to comply with this proposed AD. The average labor rate is $85 per work... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3....

  13. 75 FR 26681 - Airworthiness Directives; Turbomeca S.A. Arriel 2B and 2B1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-12

    ... Register published on April 11, 2000 (65 FR 19477-78). Discussion On April 16, 2009, the FAA issued AD 2009-09-03, Amendment 39-15889 (74 FR 18981, April 27, 2009). That AD requires performing an initial and... estimate that it would take about 2 work-hours per product to comply with this proposed AD. The...

  14. 76 FR 68661 - Airworthiness Directives; Turbomeca S.A. Arriel 2B and 2B1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-07

    .... Discussion On January 21, 2010, we issued AD 2010-03-06, Amendment 39-16189 (75 FR 5689, February 4, 2010... Issued Since we issued AD 2010-03-06 (75 FR 5689, February 4, 2010), three additional cases of uncoupling... a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February...

  15. Response of a small-turboshaft-engine compression system to inlet temperature distortion

    NASA Technical Reports Server (NTRS)

    Biesiadny, T. J.; Klann, G. A.; Little, J. K.

    1984-01-01

    An experimental investigation was conducted into the response of a small-turboshaft-engine compression system to steady-state and transient inlet temperature distortions. Transient temperature ramps range from less than 100 K/sec to above 610 K/sec and generated instantaneous temperatures to 420 K above ambient. Steady-state temperature distortion levels were limited by the engine hardware temperature list. Simple analysis of the steady-state distortion data indicated that a particle separator at the engine inlet permitted higher levels of temperature distortion before onset of compressor surge than would be expected without the separator.

  16. Status report - DARPA/NASA convertible turbofan/turboshaft engine program

    NASA Technical Reports Server (NTRS)

    Bellin, A. I.; Brooks, A.

    1983-01-01

    A development status report is presented for the NASA/Defense Advanced Research Projects Agency convertible turbofan-turboshaft engine, which can power a high speed rotorcraft in vertical flight, as well as in horizontal flight up to speeds of Mach 0.85. The basis for this development program is a modified TF34-GE-400 engine. Program objectives include both the demonstration of dual output mode (jet thrust and shaft horsepower) capability and the development of a control system which will operate the engine in either mode and convert operation between the modes.

  17. 78 FR 2198 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-10

    ...We are adopting a new airworthiness directive (AD) for all Turbomeca S.A. Arriel 1A1, 1A2, 1B, 1C, 1C1, 1C2, 1D, 1D1, 1E2, 1K1, 1S, and 1S1 turboshaft engines. This AD requires performing a high gas generator speed (NG) rating vibration check. This AD was prompted by several reports of uncommanded in-flight shutdown on Arriel 1 engines. We are issuing this AD to prevent an uncommanded in-......

  18. Real-time hybrid computer simulation of a small turboshaft engine and control system

    NASA Technical Reports Server (NTRS)

    Hart, C. E.; Wenzel, L. M.

    1984-01-01

    The development of an analytical model of a small turboshaft engine designed for helicopter propulsion systems is described. The model equations were implemented on a hybrid computer system to provide a real time nonlinear simulation of the engine performance over a wide operating range. The real time hybrid simulation of the engine was used to evaluate a microprocessor based digital control module. This digital control module was developed as part of an advanced rotorcraft control program. After tests with the hybrid engine simulation the digital control module was used to control a real engine in an experimental program. A hybrid simulation of the engine's electrical hydromechanical control system was developed. This allowed to vary the fuel flow and torque load inputs to the hybrid engine simulation for simulating transient operation. A steady-state data and the experimental tests are compared. Analytical model equations, analog computer diagrams, and a digital computer flow chart are included.

  19. Preliminary study of advanced turboprop and turboshaft engines for light aircraft. [cost effectiveness

    NASA Technical Reports Server (NTRS)

    Knip, G.; Plencner, R. M.; Eisenberg, J. D.

    1980-01-01

    The effects of engine configuration, advanced component technology, compressor pressure ratio and turbine rotor-inlet temperature on such figures of merit as vehicle gross weight, mission fuel, aircraft acquisition cost, operating, cost and life cycle cost are determined for three fixed- and two rotary-wing aircraft. Compared with a current production turboprop, an advanced technology (1988) engine results in a 23 percent decrease in specific fuel consumption. Depending on the figure of merit and the mission, turbine engine cost reductions required to achieve aircraft cost parity with a current spark ignition reciprocating (SIR) engine vary from 0 to 60 percent and from 6 to 74 percent with a hypothetical advanced SIR engine. Compared with a hypothetical turboshaft using currently available technology (1978), an advanced technology (1988) engine installed in a light twin-engine helicopter results in a 16 percent reduction in mission fuel and about 11 percent in most of the other figures of merit.

  20. Source localization of turboshaft engine broadband noise using a three-sensor coherence method

    NASA Astrophysics Data System (ADS)

    Blacodon, Daniel; Lewy, Serge

    2015-03-01

    Turboshaft engines can become the main source of helicopter noise at takeoff. Inlet radiation mainly comes from the compressor tones, but aft radiation is more intricate: turbine tones usually are above the audible frequency range and do not contribute to the weighted sound levels; jet is secondary and radiates low noise levels. A broadband component is the most annoying but its sources are not well known (it is called internal or core noise). Present study was made in the framework of the European project TEENI (Turboshaft Engine Exhaust Noise Identification). Its main objective was to localize the broadband sources in order to better reduce them. Several diagnostic techniques were implemented by the various TEENI partners. As regards ONERA, a first attempt at separating sources was made in the past with Turbomeca using a three-signal coherence method (TSM) to reject background non-acoustic noise. The main difficulty when using TSM is the assessment of the frequency range where the results are valid. This drawback has been circumvented in the TSM implemented in TEENI. Measurements were made on a highly instrumented Ardiden turboshaft engine in the Turbomeca open-air test bench. Two engine powers (approach and takeoff) were selected to apply TSM. Two internal pressure probes were located in various cross-sections, either behind the combustion chamber (CC), the high-pressure turbine (HPT), the free-turbine first stage (TL), or in four nozzle sections. The third transducer was a far-field microphone located around the maximum of radiation, at 120° from the intake centerline. The key result is that coherence increases from CC to HPT and TL, then decreases in the nozzle up to the exit. Pressure fluctuations from HPT and TL are very coherent with the far-field acoustic spectra up to 700 Hz. They are thus the main acoustic source and can be attributed to indirect combustion noise (accuracy decreases above 700 Hz because coherence is lower, but far-field sound spectra

  1. Forced Response Testing of an Axi-Centrifugal Turboshaft Engine

    NASA Technical Reports Server (NTRS)

    Owen, A. Karl; Mattern, Duane L.; Braun, Donald C.; Le, Dzu K.

    1996-01-01

    Dynamic data from tests of a T55-L,712 engine are presented. Engine stall/surge data were analyzed using digital signal processing techniques. In addition, forced response testing (system identification studies) was done at various engine speeds. Forced response testing was done using eight jet ejectors approximately equally circumferentially spaced about the compressor front face. This paper presents some preliminary results for the ground idle (approximately 60% of design speed) point. Brief descriptions of the jet injection system, the test matrix, and analysis techniques used are presented. Results of these analyses indicate a substantial transfer of energy across the compressor first stage at some frequencies and that the ejectors are effective in modifying the local flow conditions in front of the first compressor stage.

  2. Forced response testing of an axi-centrifugal turboshaft engine

    NASA Technical Reports Server (NTRS)

    Owen, A. Karl; Le, Dzu K.; Braun, Donald C.; Mattern, Duane L.

    1996-01-01

    Dynamic data from tests of a T55-L-712 engine are presented. Engine stall/surge data were analyzed using digital signal processing techniques. In addition, forced response testing (system identification studies) was done at various engine speeds. Forced response testing was done using eight jet ejectors approximately equally circumferentially spaced about the compressor front face. This paper presents some preliminary results for the ground idle (approximately 60% of design speed) point. Brief descriptions of the jet injection system, the test matrix, and analysis techniques used are presented. Results of these analyses indicate a substantial transfer of energy across the compressor first stage at some frequencies and that the ejectors are effective in modifying the local flow conditions in front of the first compressor stage.

  3. Model-Based Fault Diagnosis for Turboshaft Engines

    NASA Technical Reports Server (NTRS)

    Green, Michael D.; Duyar, Ahmet; Litt, Jonathan S.

    1998-01-01

    Tests are described which, when used to augment the existing periodic maintenance and pre-flight checks of T700 engines, can greatly improve the chances of uncovering a problem compared to the current practice. These test signals can be used to expose and differentiate between faults in various components by comparing the responses of particular engine variables to the expected. The responses can be processed on-line in a variety of ways which have been shown to reveal and identify faults. The combination of specific test signals and on-line processing methods provides an ad hoc approach to the isolation of faults which might not otherwise be detected during pre-flight checkout.

  4. GUI Type Fault Diagnostic Program for a Turboshaft Engine Using Fuzzy and Neural Networks

    NASA Astrophysics Data System (ADS)

    Kong, Changduk; Koo, Youngju

    2011-04-01

    The helicopter to be operated in a severe flight environmental condition must have a very reliable propulsion system. On-line condition monitoring and fault detection of the engine can promote reliability and availability of the helicopter propulsion system. A hybrid health monitoring program using Fuzzy Logic and Neural Network Algorithms can be proposed. In this hybrid method, the Fuzzy Logic identifies easily the faulted components from engine measuring parameter changes, and the Neural Networks can quantify accurately its identified faults. In order to use effectively the fault diagnostic system, a GUI (Graphical User Interface) type program is newly proposed. This program is composed of the real time monitoring part, the engine condition monitoring part and the fault diagnostic part. The real time monitoring part can display measuring parameters of the study turboshaft engine such as power turbine inlet temperature, exhaust gas temperature, fuel flow, torque and gas generator speed. The engine condition monitoring part can evaluate the engine condition through comparison between monitoring performance parameters the base performance parameters analyzed by the base performance analysis program using look-up tables. The fault diagnostic part can identify and quantify the single faults the multiple faults from the monitoring parameters using hybrid method.

  5. 75 FR 59065 - Airworthiness Directives; Turboméca S.A. Arriel 2B and 2B1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    ..., whichever occurs first, if the rearward displacement of the turbine blades was less than 0.2 mm. Replace HP... previous inspection if the rearward displacement of the turbine blades was between 0.2 mm and 0.5 mm... AD as of June 1, 2009 (74 FR 18981, April 27, 2009). ADDRESSES: The Docket Operations office...

  6. 75 FR 16664 - Airworthiness Directives; Turbomeca ARRIEL 1B, 1D, 1D1, 2B, and 2B1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... Register on December 23, 2009 (74 FR 68194). That NPRM proposed to correct an unsafe condition for the... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or.... The MCAI describes the unsafe condition as: During production of Arriel 1 and Arriel 2 Power...

  7. Small Engine Technology. Task 4: Advanced Small Turboshaft Compressor (ASTC) Performance and Range Investigation

    NASA Technical Reports Server (NTRS)

    Hansen, Jeff L.; Delaney, Robert A.

    1997-01-01

    This contact had two main objectives involving both numerical and experimental investigations of a small highly loaded two-stage axial compressor designated Advanced Small Turboshaft Compressor (ASTC) winch had a design pressure ratio goal of 5:1 at a flowrate of 10.53 lbm/s. The first objective was to conduct 3-D Navier Stokes multistage analyses of the ASTC using several different flow modelling schemes. The second main objective was to complete a numerical/experimental investigation into stall range enhancement of the ASTC. This compressor was designed wider a cooperative Space Act Agreement and all testing was completed at NASA Lewis Research Center. For the multistage analyses, four different flow model schemes were used, namely: (1) steady-state ADPAC analysis, (2) unsteady ADPAC analysis, (3) steady-state APNASA analysis, and (4) steady state OCOM3D analysis. The results of all the predictions were compared to the experimental data. The steady-state ADPAC and APNASA codes predicted similar overall performance and produced good agreement with data, however the blade row performance and flowfield details were quite different. In general, it can be concluded that the APNASA average-passage code does a better job of predicting the performance and flowfield details of the highly loaded ASTC compressor.

  8. 78 FR 77614 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ...-09R1, Amendment 39-16322 (75 FR 30687, June 2, 2010). That AD applies to all Turbomeca S.A. 2B1... Since Existing AD Was Issued Since we issued AD 2007-19-09R1, Amendment 39-16322 (75 FR 30687, June 2... requirements of AD 2007-19- 09R1, Amendment 39-16322 (75 FR 30687, June 2, 2010) but would reduce...

  9. 78 FR 9007 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-07

    ...-08-14R1, Amendment 39-14423 (71 FR 2993, January 19, 2006), for all Arrius Models 2B, 2B1, and 2F... AD Was Issued Since we issued AD 2001-08-14R1, Amendment 39-14423 (71 FR 2993, January 19, 2006... and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska...

  10. 75 FR 57371 - Airworthiness Directives; Turbomeca Arriel 1 Series Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-21

    ... April 11, 2000 (65 FR 19477-78). Authority for This Rulemaking Title 49 of the United States Code... Order 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR... Engineer, Engine Certification Office, FAA, Engine & Propeller Directorate, 12 New England Executive...

  11. 76 FR 8321 - Special Conditions: Pratt and Whitney Canada Model PW210S Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-14

    ... engine operation in auxiliary power unit (APU) mode. The applicable airworthiness regulations do not... power unit (APU) mode. The helicopter will incorporate a main rotor brake what will allow the engine... generator portion of the engine continues to operate as an APU while on the ground. The...

  12. 77 FR 61303 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78). Discussion The European... it would take about 0.7 work-hour per engine to comply with this proposed AD. The average labor rate is $85 per work-hour. Required parts would cost about $14,400 per engine. Based on these figures,...

  13. 77 FR 73557 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034... engines. This proposed AD was prompted by a finding that the engine's tachometer unit cycle...

  14. 76 FR 33981 - Special Conditions: Pratt and Whitney Canada Model PW210S Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-10

    ... for the PW210S engine model was published on February 14, 2011 (76 FR 8321). One comment letter was... unit (APU) mode. The applicable airworthiness regulations do not contain adequate or appropriate safety... novel or unusual design feature, which is engine operation in auxiliary power unit (APU) mode....

  15. Emissions of Volatile Particulate Components from Turboshaft Engines running JP-8 and Fischer-Tropsch Fuels

    SciTech Connect

    Cheng, Mengdawn; Corporan, E.; DeWitt, M.; Landgraf, Bradley J

    2009-01-01

    Rotating-wing aircraft or helicopters are heavily used by the US military and also a wide range of commercial applications around the world, but emissions data for this class of engines are limited. In this study, we focus on emissions from T700-GE-700 and T700-GE-701C engines; T700 engine was run with military JP-8 and T701C run with both JP-8 and Fischer-Tropsch (FT) fuels. Each engine was run at three engine power settings from the idle to maximum power in sequence. Exhaust particles measured at the engine exhaust plane (EEP) have a peak mobility diameter less than 50nm in all engine power settings. At a 4-m downstream location, sulfate/sulfur measurements indicate all particulate sulfur exists practically as sulfate, and the particulate sulfur and sulfate contents increased as the engine power increased. The conversion of sulfur to sulfate was found not to be dependent on engine power setting. Analysis also showed that conversion of sulfur to sulfate was not by the adsorption of sulfur dioxide gas on the soot particles and then subsequently oxidized to form sulfate, but by gas-phase conversion of SO2 via OH or O then subsequently forming H2SO4 and condensing on soot particles. Without the sulfur and aromatic components, use of the FT fuel led to significant reduction of soot emissions as compared to that of the JP-8 fuel producing less number of particles than that of the JP-8 fuel; however, the FT fuel produced much higher number concentrations of particles smaller than 7nm than that of JP-8 in all engine power settings. This indicates non-aromatics components in the FT fuel could have contributed to the enhancement of emissions of particles smaller than 7nm. These small particles are volatile, not observed at the EEP, and may be important in playing a role for the formation of secondary particles in the atmosphere or serving as a site for effective cloud nuclei condensation to occur.

  16. Contingency power for a small turboshaft engine by using water injection into turbine cooling air

    NASA Technical Reports Server (NTRS)

    Biesiadny, Thomas J.; Klann, Gary A.

    1992-01-01

    Because of one-engine-inoperative (OEI) requirements, together with hot-gas reingestion and hot-day, high-altitude take-off situations, power augmentation for multiengine rotorcraft has always been of critical interest. However, power augmentation by using overtemperature at the turbine inlet will shorten turbine life unless a method of limiting thermal and mechanical stress is found. A possible solution involves allowing the turbine inlet temperature to rise to augment power while injecting water into the turbine cooling air to limit hot-section metal temperatures. An experimental water injection device was installed in an engine and successfully tested. Although concern for unprotected subcomponents in the engine hot section prevented demonstration of the technique's maximum potential, it was still possible to demonstrate increases in power while maintaining nearly constant turbine rotor blade temperature.

  17. Contingency power for small turboshaft engines using water injection into turbine cooling air

    NASA Technical Reports Server (NTRS)

    Biesiadny, Thomas J.; Berger, Brett; Klann, Gary A.; Clark, David A.

    1987-01-01

    Because of one engine inoperative requirements, together with hot-gas reingestion and hot day, high altitude takeoff situations, power augmentation for multiengine rotorcraft has always been of critical interest. However, power augmentation using overtemperature at the turbine inlet will shorten turbine life unless a method of limiting thermal and mechanical stresses is found. A possible solution involves allowing the turbine inlet temperature to rise to augment power while injecting water into the turbine cooling air to limit hot-section metal temperatures. An experimental water injection device was installed in an engine and successfully tested. Although concern for unprotected subcomponents in the engine hot section prevented demonstration of the technique's maximum potential, it was still possible to demonstrate increases in power while maintaining nearly constant turbine rotor blade temperature.

  18. Dynamic and Transient Performance of Turbofan/Turboshaft Convertible Engine With Variable Inlet Guide Vanes

    NASA Technical Reports Server (NTRS)

    McArdle, Jack G.; Barth, Richard L.; Wenzel, Leon M.; Biesiadny, Thomas J.

    1996-01-01

    A convertible engine called the CEST TF34, using the variable inlet guide vane method of power change, was tested on an outdoor stand at the NASA Lewis Research Center with a waterbrake dynamometer for the shaft load. A new digital electronic system, in conjunction with a modified standard TF34 hydromechanical fuel control, kept engine operation stable and safely within limits. All planned testing was completed successfully. Steady-state performance and acoustic characteristics were reported previously and are referenced. This report presents results of transient and dynamic tests. The transient tests measured engine response to several rapid changes in thrust and torque commands at constant fan (shaft) speed. Limited results from dynamic tests using the pseudorandom binary noise technique are also presented. Performance of the waterbrake dynamometer is discussed in an appendix.

  19. 78 FR 48824 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-12

    ... Register published on April 11, 2000 (65 FR 19477-78). Discussion The European Aviation Safety Agency (EASA... 12866, (2) Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034... was prompted by a ``chip illumination event'' in flight on a Turbomeca S.A. Arriel 1 engine....

  20. 78 FR 6725 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-31

    ... pressure event caused by deterioration and a loss of the low- pressure drive function within the hydro-mechanical metering unit (HMU). This AD requires replacing the HMU at a reduced life. We are issuing this AD to prevent an uncommanded in-flight shutdown of the engine, and possible loss of the...

  1. 77 FR 9874 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-21

    ... Register published on April 11, 2000 (65 FR 19477-78). Discussion The European Aviation Safety Agency (EASA... one work-hour per engine to comply with this proposed AD. The average labor rate is $85 per work-hour... Order 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44...

  2. 76 FR 72091 - Airworthiness Directives; Turbomeca S.A. Makila 1A2 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-22

    ... Register published on April 11, 2000 (65 FR 19477-78). Authority for This Rulemaking Title 49 of the United... Procedures (44 FR 11034, February 26, 1979), and 3. Will not have a significant economic impact, positive or... control mode, which could result in engine power loss and emergency landing of the helicopter. DATES:...

  3. 76 FR 73494 - Airworthiness Directives; Turbomeca S.A. Arriel 2B Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-29

    ... FR 19477-78). Authority for This Rulemaking Title 49 of the United States Code specifies the FAA's... ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and (3... the FAA, Engine & Propeller Directorate, 12 New England Executive Park, Burlington, MA....

  4. 77 FR 65142 - Airworthiness Directives; Pratt & Whitney Canada Corp Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-25

    ... Register published on April 11, 2000 (65 FR 19477-78). Discussion The Transport Canada, which is the... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... located near the second stage PT disk. If the engine fails the inspection, this proposed AD would...

  5. 77 FR 66767 - Airworthiness Directives; Pratt & Whitney Canada Corp. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-07

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... the FAA, Engine & Propeller Directorate, 12 New England Executive Park, Burlington, MA....

  6. Band Structure Engineering by Substitutional Doping in Solid-State Solutions of [5-Me-PLY(O,O)]2B(1-x)Be(x) Radical Crystals.

    PubMed

    Bag, Pradip; Itkis, Mikhail E; Stekovic, Dejan; Pal, Sushanta K; Tham, Fook S; Haddon, Robert C

    2015-08-12

    We report the substitutional doping of solid-state spiro-bis(5-methyl-1,9-oxido-phenalenyl)boron radical ([2]2B) by co-crystallization of this radical with the corresponding spiro-bis(5-methyl-1,9-oxido-phenalenyl)beryllium compound ([2]2Be). The pure compounds crystallize in different space groups ([2]2B, P1̅, Z = 2; [2]2Be, P2₁/c, Z = 4) with distinct packing arrangements, yet we are able to isolate crystals of composition [2]2B(1-x)Be(x), where x = 0-0.59. The phase transition from the P1̅ to the P2₁/c space group occurs at x = 0.1, but the conductivities of the solid solutions are enhanced and the activation energies reduced for values of x = 0-0.25. The molecular packing is driven by the relative concentration of the spin-bearing ([2]2B) and spin-free ([2]2Be) molecules in the crystals, and the extended Hückel theory band structures show that the progressive incorporation of spin-free [2]2Be in the lattice of the [2]2B radical (overall bandwidth, W = 1.4 eV, in the pure compound) leads to very strong narrowing of the bandwidth, which reaches a minimum at [2]2Be (W = 0.3 eV). The results provide a graphic picture of the structural transformations undergone by the lattice, and at certain compositions we are able to identify distinct structures for the [2]2B and [2]2Be molecules in a single crystalline phase. PMID:26235568

  7. Comparisons of Rig and Engine Dynamic Events in the Compressor of an Axi-Centrifugal Turboshaft Engine

    NASA Technical Reports Server (NTRS)

    Owen, A. Karl; Mattern, Duane L.; Le, Dzu K.

    1996-01-01

    Steady state and dynamic data were acquired in a T55-L-712 compressor rig. In addition, a T55-L-12 engine was instrumented and similar data were acquired. Rig and engine stall/surge data were analyzed using modal techniques. This paper compares rig and engine preliminary results for the ground idle (approximately 60% of design speed) point. The results of these analyses indicate both rig and engine dynamic event are preceded by indications of traveling wave energy in front of the compressor face. For both rig and engine, the traveling wave energy contains broad band energy with some prominent narrow peaks and, while the events are similar in many ways, some noticeable differences exist between the results of the analyses of rig data and engine data.

  8. 76 FR 11940 - Airworthiness Directives; Turbomeca Model Arriel 1E2, 1S, and 1S1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-04

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78...'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have... uncommanded engine in-flight shutdown. This AD requires the same actions and compliance times as the...

  9. 75 FR 32260 - Airworthiness Directives; Turbomeca S.A. MAKILA 1A and 1A1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-08

    ... to the specified products. That NPRM was published in the Federal Register on March 31, 2010 (75 FR... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant... resulted in a few occurrences of erratic engine behaviour, in the form of unexpected N1 variations...

  10. Study of LH2-fueled topping cycle engine for aircraft propulsion

    NASA Technical Reports Server (NTRS)

    Turney, G. E.; Fishbach, L. H.

    1983-01-01

    An analytical investigation was made of a topping cycle aircraft engine system which uses a cryogenic fuel. This system consists of a main turboshaft engine which is mechanically coupled (by cross-shafting) to a topping loop which augments the shaft power output of the system. The thermodynamic performance of the topping cycle engine was analyzed and compared with that of a reference (conventional-type) turboshaft engine. For the cycle operating conditions selected, the performance of the topping cycle engine in terms of brake specific fuel consumption (bsfc) was determined to be about 12 percent better than that of the reference turboshaft engine. Engine weights were estimated for both the topping cycle engine and the reference turboshaft engine. These estimates were based on a common shaft power output for each engine. Results indicate that the weight of the topping cycle engine is comparable to that of the reference turboshaft engine.

  11. Analysis of a topping-cycle, aircraft, gas-turbine-engine system which uses cryogenic fuel

    NASA Technical Reports Server (NTRS)

    Turney, G. E.; Fishbach, L. H.

    1984-01-01

    A topping-cycle aircraft engine system which uses a cryogenic fuel was investigated. This system consists of a main turboshaft engine that is mechanically coupled (by cross-shafting) to a topping loop, which augments the shaft power output of the system. The thermodynamic performance of the topping-cycle engine was analyzed and compared with that of a reference (conventional) turboshaft engine. For the cycle operating conditions selected, the performance of the topping-cycle engine in terms of brake specific fuel consumption (bsfc) was determined to be about 12 percent better than that of the reference turboshaft engine. Engine weights were estimated for both the topping-cycle engine and the reference turboshaft engine. These estimates were based on a common shaft power output for each engine. Results indicate that the weight of the topping-cycle engine is comparable with that of the reference turboshaft engine.

  12. Experimental program for the evaluation of turbofan/turboshaft c conversion technology

    NASA Technical Reports Server (NTRS)

    Mcardle, J. G.; Wenzel, L. M.

    1981-01-01

    A TF34 turbofan engine is being modified to produce shaft power from an output coupling on the fan disk when variable inlet guide vanes are closed to reduce fan airflow. The engine, called a convertible engine, could be used on advanced rotorcraft such as X-wing, ABC (Advanced Blade Concept), and Folding Tilt Rotor, and on V/STOL craft in which two engines are cross-coupled. The engine will be tested on an outdoor static test stand at NASA Lewis Research Center. Steady-state tests will be made to measure performance in turbofan, turboshaft, and combined power output modes. Transient tests will be made to determine the response to the engine and a new digital engine control system for several types of rapid changes in thrust and shaft loads. The paper describes the engine modifications, the test facility equipment, proposed testing techniques for several types of tests, and typical test results predicted from engine performance computer programs.

  13. NACA D-558-2 Test Force w/P2B-1S & F-86

    NASA Technical Reports Server (NTRS)

    1952-01-01

    These people and this equipment supported the flight of the NACA D-558-2 Skyrocket at the High-Speed Flight Station at South Base, Edwards AFB. Note the two Sabre chase planes, the P2B-1S launch aircraft, and the profusion of ground support equipment, including communications, tracking, maintenance, and rescue vehicles. Research pilot A. Scott Crossfield stands in front of the Skyrocket. Three D-558-2 'Skyrockets' were built by Douglas Aircraft, Inc. for NACA and the Navy. The mission of the D-558-2 program was to investigate the flight characteristics of a swept-wing aircraft at high supersonic speeds. Particular attention was given to the problem of 'pitch-up,' a phenomenon often encountered with swept-wing configured aircraft. The D-558-2 was a single-place, 35-degree swept-wing aircraft measuring 42 feet in length. It was 12 feet, 8 inches in height and had a wingspan of 25 feet. Fully fueled it weighed from about 10,572 pounds to 15,787 pounds depending on configuration. The first of the three D-558-IIs had a Westinghouse J34-40 jet engine and took off under its own power. The second was equipped with a turbojet engine replaced in 1950 with a Reaction Motors Inc. LR8-RM-6 rocket engine. This aircraft was modified so it could be air-launched from a P2B-1S (Navy designation for the B-29) carrier aircraft. The third Skyrocket had the jet engine and the rocket engine but was also modified so it could be air-launched. The jet engine was for takeoff and climbing to altitude and the four-chambered rocket engine was for reaching supersonic speeds. The rocket engine was rated at 6,000 pounds of thrust. The D-558-2 was first flown on Feb. 4, 1948, by John Martin, a Douglas test pilot. A NACA pilot, Scott Crossfield, became the first person to fly faster than twice the speed of sound when he piloted the D-558-II to its maximum speed of 1,291 miles per hour on Nov. 20, 1953. Its peak altitude, 83,235 feet, a record in its day, was reached with USMC Lt. Col. Marion Carl

  14. Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1

    SciTech Connect

    Kozu, Tomoko; Henrich, B.; Schaefer, K.P.

    1995-01-20

    Heterogeneous nuclear ribonucleoprotein (hnRNP) A2 is a major nuclear protein and one of the major components of the hnRNP core complex in mammalian cells. We first determined the complete sequence of the human gene for hnRNP protein A2 (HNRPA2B1). The human HNRPA2B1 gene exists in a single copy over 9 kb in length. The gene was split into 12 exons, including a 36-nucleotide mini-exon, which was specific to the hnRNP protein B1, providing genetic evidence that the B1 mRNA was generated from the primary HNRPA2B1 transcript by alternative splicing. The 5{prime} region of HNRPA2B1 was GC-rich and contained several DNA motifs for the binding of several transcription factors, which included 2 CCAAT boxes and no TATA sequences. The 5{prime} ends of the mRNA were mapped to multiple positions. These structural features are characteristic of promoter regions of housekeeping genes. Northern blot and RT-PCR analyses of the HNRPA2B1 transcripts revealed levels of B1 mRNA from 2 to 5% of total A2/B1 transcripts and showed that both A2 and B1 mRNAs were transcribed in all human cell lines and mouse tissues studied. The structural and evolutionary characteristics of the A2 and A1 proteins as they relate to each other are discussed. 38 refs., 5 figs.

  15. HUMAN CYTOSOLIC SULFOTRANSFERASE 2B1: ISOFORM EXPRESSION, TISSUE SPECIFICITY AND SUBCELLULAR LOCALIZATION

    PubMed Central

    Falany, C.N.; He, D.; Dumas, N.; Frost, A.R.; Falany, J.L.

    2007-01-01

    Sulfation is an important Phase II conjugation reaction involved in the synthesis and metabolism of steroids in humans. Two different isoforms (2B1a and 2B1b) are encoded by the sulfotransferase (SULT) 2B1 gene utilizing different start sites of transcription resulting in the incorporation of different first exons. SULT2B1a and SULT2B1b are 350 and 365 amino acids in length, respectively, and the last 342 aa are identical. Message for both SULT2B1 isoforms is present in human tissues although SULT2B1b message is generally more abundant. However, to date only SULT2B1b protein has been detected in human tissues or cell lines. SULT2B1b is localized in the cytosol and/or nuclei of human cells. A unique 3′-extension of SULT2B1b is required for nuclear localization in human BeWo placental choriocarcinoma cells. Nuclear localization is stimulated by forskolin treatment in BeWo cells and serine phosphorylation has been identified in the 3′-extension. SULT2B1b is selective for the sulfation of 3β-hydroxysteroids such as dehydroepiandrosterone and pregnenolone, and may also have a role in cholesterol sulfation in human skin. The substrate specificity, nuclear localization, and tissue localization of SULT2B1b suggest a role in regulating the responsiveness of cells to adrenal androgens via their direct inactivation or by preventing their conversion to more potent androgens and estrogens. PMID:17055258

  16. The SH2B1 Adaptor Protein Associates with a Proximal Region of the Erythropoietin Receptor*

    PubMed Central

    Javadi, Mojib; Hofstätter, Edda; Stickle, Natalie; Beattie, Bryan K.; Jaster, Robert; Carter-Su, Christin; Barber, Dwayne L.

    2012-01-01

    Gene targeting experiments have shown that the cytokine erythropoietin (EPO), its cognate erythropoietin receptor (EPO-R), and associated Janus tyrosine kinase, JAK2, are all essential for erythropoiesis. Structural-functional and murine knock-in experiments have suggested that EPO-R Tyr-343 is important in EPO-mediated mitogenesis. Although Stat5 binds to EPO-R phosphotyrosine 343, the initial Stat5-deficient mice did not have profound erythroid abnormalities suggesting that additional Src homology 2 (SH2) domain-containing effectors may bind to EPO-R Tyr-343 and couple to downstream signaling pathways. We have utilized cloning of ligand target (COLT) screening to demonstrate that EPO-R Tyr(P)-343 and Tyr(P)-401 bind to the SH2 domain-containing adaptor protein SH2B1β. Immunoprecipitation and in vitro mixing experiments reveal that EPO-R binds to SH2B1 in an SH2 domain-dependent manner and that the sequence that confers SH2B1 binding to the EPO-R is pYXXL. Previous studies have shown that SH2B1 binds directly to JAK2, but we show that in hematopoietic cells, SH2B1β preferentially associates with the EPO-R. SH2B1 is capable of constitutive association with EPO-R, which is necessary for its optimal SH2-dependent recruitment to EPO-R-Tyr(P)-343/Tyr(P)-401. We also demonstrate that SH2B1 is responsive to EPO stimulation and becomes phosphorylated, most likely on serines/threonines, in an EPO dose- and time-dependent manner. In the absence of SH2B1, we observe enhanced activation of signaling pathways downstream of the EPO-R, indicating that SH2B1 is a negative regulator of EPO signaling. PMID:22669948

  17. The SH2B1 adaptor protein associates with a proximal region of the erythropoietin receptor.

    PubMed

    Javadi, Mojib; Hofstätter, Edda; Stickle, Natalie; Beattie, Bryan K; Jaster, Robert; Carter-Su, Christin; Barber, Dwayne L

    2012-07-27

    Gene targeting experiments have shown that the cytokine erythropoietin (EPO), its cognate erythropoietin receptor (EPO-R), and associated Janus tyrosine kinase, JAK2, are all essential for erythropoiesis. Structural-functional and murine knock-in experiments have suggested that EPO-R Tyr-343 is important in EPO-mediated mitogenesis. Although Stat5 binds to EPO-R phosphotyrosine 343, the initial Stat5-deficient mice did not have profound erythroid abnormalities suggesting that additional Src homology 2 (SH2) domain-containing effectors may bind to EPO-R Tyr-343 and couple to downstream signaling pathways. We have utilized cloning of ligand target (COLT) screening to demonstrate that EPO-R Tyr(P)-343 and Tyr(P)-401 bind to the SH2 domain-containing adaptor protein SH2B1β. Immunoprecipitation and in vitro mixing experiments reveal that EPO-R binds to SH2B1 in an SH2 domain-dependent manner and that the sequence that confers SH2B1 binding to the EPO-R is pYXXL. Previous studies have shown that SH2B1 binds directly to JAK2, but we show that in hematopoietic cells, SH2B1β preferentially associates with the EPO-R. SH2B1 is capable of constitutive association with EPO-R, which is necessary for its optimal SH2-dependent recruitment to EPO-R-Tyr(P)-343/Tyr(P)-401. We also demonstrate that SH2B1 is responsive to EPO stimulation and becomes phosphorylated, most likely on serines/threonines, in an EPO dose- and time-dependent manner. In the absence of SH2B1, we observe enhanced activation of signaling pathways downstream of the EPO-R, indicating that SH2B1 is a negative regulator of EPO signaling. PMID:22669948

  18. Hydroxysteroid sulfotransferase 2B1b expression and localization in normal human brain

    PubMed Central

    Salman, Emily D.; Faye-Petersen, Ona; Falany, Charles N.

    2012-01-01

    Steroid sulfonation in the human brain has not been well characterized. The major sulfotransferase (SULT) isoforms that conjugate steroids in humans are SULT1E1, SULT2A1, and SULT2B1b. SULT2B1b catalyzes the sulfonation of 3β-hydroxysteroids, including neurosteroids dehydroepiandrosterone and pregnenolone, as well as cholesterol and several hydroxycholesterols. SULT2B1b mRNA and protein expression were detected in adult and fetal human brain sections, whereas neither mRNA, nor protein expression were identified for SULT1E1 or SULT2A1. Using immunohistochemical analysis, SULT2B1b expression was detected in neurons and oligodendrocytes in adult brain and in epithelial tissues in 28-week-old fetal brain. Sulfonation of cholesterol, oxysterols, and neurosteroids in the brain is apparently catalyzed by SULT2B1b since expression of neither SULT2A1 nor SULT1E1 was detected in human brain sections. SULT2B1b mRNA and protein were also detected in human U373-MG glioblastoma cells. Both mRNA and protein expression of liver X receptor (LXR)-β, but not LXR-α, were detected in U373-MG cells, and LXR-β activation resulted in a decrease in SULT2B1b protein expression. Since hydroxycholesterols are important physiological LXR activators, this suggests a role for regulation of sterol metabolism by LXR and SULT2B1b. Therefore, elucidating key enzymes in the metabolism of cholesterol and neurosteroids could help define the properties of steroid conjugation in the human brain. PMID:24683427

  19. Collisional Removal of O2(b1Σ ^+g, v = 1) by Atomic Oxygen

    NASA Astrophysics Data System (ADS)

    Kalogerakis, K. S.; Pejaković, D. A.; Copeland, R. A.; Slanger, T. G.

    2004-12-01

    In the thermosphere, energy transfer between excited O atoms and ground-state molecular oxygen produces O2 in the first two vibrational levels of the b1Σ ^+g state: O(1D) + O2 -> O(3P) + O2(b1Σ ^+g, v = 0, 1). Subsequent radiative decay of O2(b1Σ ^+g, v = 0, 1) to the ground state O2(X3Σ ^-g) results in the Atmospheric Band emissions. Atmospheric observations suggest that above ˜120 km O(3P) plays an important role in removing O2(b1Σ ^+g, v = 1). Therefore, knowledge of the rate coefficient for collisional removal of O2(b1Σ ^+g<, v = 1) by O(3P) is important for detailed understanding of the Atmospheric Band emissions. Measurements are reported of the room-temperature rate coefficient for removal of O2(b1Σ ^+g, v = 1) by O(3P). A commercial F2 laser with pulsed energy output of up to 50 mJ at 157 nm is used to photodissociate a large fraction of molecular oxygen in a O2/N2 mixture. Photodissociation of an O2 molecule produces a ground-state oxygen atom O(3P) and an excited oxygen atom O(1D), and O(1D) rapidly transfers energy to the remaining O2 to produce O2(b1Σ ^+g, v = 0, 1). The O2(b1Σ ^+g, v = 1) population is monitored by observing emission in the O2 (b-X) 1--1 band at 771 nm. To extract the O2(b1Σ ^+g, v = 1) + O(3P) rate coefficient, knowledge of the O(3P) partial pressure or, equivalently, the fraction of dissociated O2, is necessary. Based on the F2 laser fluence, the signal dependence on the fraction of dissociation, and computer modeling, the signals measured in our experiments correspond to about 50% dissociation. Our measurements yield a preliminary value of the rate coefficient for O2(b1Σ ^+g, v = 1) removal by O(3P) of 6 × 10-12 cm3s-1. The results will be compared to the rate coefficients for corresponding processes in the ground and a1Δ g states of O2, and implications of the results for modeling of the upper atmosphere will be discussed. This work is supported by the NSF Aeronomy Program under grant ATM-0209229. The F2 laser was

  20. Binding and cytotoxicity characteristics of the bispecific murine monoclonal antibody 2B1.

    PubMed

    Weiner, L M; Holmes, M; Richeson, A; Godwin, A; Adams, G P; Hsieh-Ma, S T; Ring, D B; Alpaugh, R K

    1993-09-01

    Bispecific monoclonal antibodies (BsmAb) with specificity for tumor Ag and effector cell trigger molecules have been shown to redirect the cytotoxicity of several peripheral blood mononuclear cell populations against relevant tumor. The BsmAb, 2B1, binds to the extracellular domain of the c-erbB-2 gene product of the HER2/neu proto-oncogene and to CD16. In this report, the binding and cytotoxic characteristics of 2B1 are presented. Maximal saturation binding of 2B1 to PBL and c-erbB-2 expressing SK-OV-3 cells occurred in the 1 microgram/ml concentration range. However, substantial lysis potentiation was observed at 1000-fold lower BsmAb concentrations. Optimal tumor lysis was obtained when the BsmAb, PBL, and target cells were continuously coincubated. When PBL were franked with 2B1, washed, and added to labeled targets, substantially less lysis was observed. These results suggest that the best way to therapeutically exploit the cytotoxic attributes of 2B1 may be to obtain continuous BsmAb exposure to tumor. Approaches based on franking of this BsmAb to PBL may not be warranted. PMID:8103070

  1. D-558-2 being mounted to P2B-1S launch aircraft

    NASA Technical Reports Server (NTRS)

    1953-01-01

    This 1953 NACA High-Speed Flight Research Station photograph shows the Douglas D-558-2 #2 Skyrocket (NACA 144), prior to flight, being towed under the P2B-1S (Navy designation for the Air Force B-29) launch vehicle (NACA 137) for attachment. In this view the tail of the Skyrocket is almost aligned with the opening cut to fit in the bottom of the P2B-1S. The photograph also shows the large hydraulic jacks used to elevate the P2B-1S launch vehicle. The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and X-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS). Also partners in the flight research were the Navy-Marine Corps and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service

  2. D-558-2 being mounted to P2B-1S launch aircraft in hangar

    NASA Technical Reports Server (NTRS)

    1954-01-01

    This 1954 photograph shows a Douglas D-558-2 under the P2B-1S (Navy designation for a B-29) launch aircraft. The P2B-1S has been lifted on mechanical jacks in the hangar for a possible 'fit check' or the attachment of the Skyrocket for a flight. The P2B-1S had the nickname 'Fertile Myrtle.' On the side of its fuselage is a series of images indicating 41 launches by the mothership of D-558-2 #2 (NACA 144) and 44 by D-558-2 #3 (NACA 145). The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and XF-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS); the Navy-Marine Corps; and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service aircraft of that era, particularly at low speeds

  3. D-558-2 being mounted to P2B-1S launch aircraft

    NASA Technical Reports Server (NTRS)

    1953-01-01

    This 1953 NACA High-Speed Flight Research Station photograph shows the Douglas D-558-2 #2 Skyrocket (NACA 144), prior to flight, being towed under the P2B-1S launch vehicle (NACA 137) for attachment. The photograph also shows the large hydraulic jacks used to elevate the P2B-1S launch vehicle. Once the D-558-2 was in position, the P2B-1S would be lowered and the attachment made. The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and X-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS); the Navy-Marine Corps; and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service aircraft of that era, particularly at low speeds during take-off and landing and in tight turns. The three

  4. The design of a turboshaft speed governor using modern control techniques

    NASA Technical Reports Server (NTRS)

    Delosreyes, G.; Gouchoe, D. R.

    1986-01-01

    The objectives of this program were: to verify the model of off schedule compressor variable geometry in the T700 turboshaft engine nonlinear model; to evaluate the use of the pseudo-random binary noise (PRBN) technique for obtaining engine frequency response data; and to design a high performance power turbine speed governor using modern control methods. Reduction of T700 engine test data generated at NASA-Lewis indicated that the off schedule variable geometry effects were accurate as modeled. Analysis also showed that the PRBN technique combined with the maximum likelihood model identification method produced a Bode frequency response that was as accurate as the response obtained from standard sinewave testing methods. The frequency response verified the accuracy of linear models consisting of engine partial derivatives and used for design. A power turbine governor was designed using the Linear Quadratic Regulator (LQR) method of full state feedback control. A Kalman filter observer was used to estimate helicopter main rotor blade velocity. Compared to the baseline T700 power turbine speed governor, the LQR governor reduced droop up to 25 percent for a 490 shaft horsepower transient in 0.1 sec simulating a wind gust, and up to 85 percent for a 700 shaft horsepower transient in 0.5 sec simulating a large collective pitch angle transient.

  5. A simplified life-cycle cost comparison of various engines for small helicopter use

    NASA Technical Reports Server (NTRS)

    Civinskas, K. C.; Fishbach, L. M.

    1974-01-01

    A ten-year, life-cycle cost comparison is made of the following engines for small helicopter use: (1) simple turboshaft; (2) regenerative turboshaft; (3) compression-ignition reciprocator; (4) spark-ignited rotary; and (5) spark-ignited reciprocator. Based on a simplified analysis and somewhat approximate data, the simple turboshaft engine apparently has the lowest costs for mission times up to just under 2 hours. At 2 hours and above, the regenerative turboshaft appears promising. The reciprocating and rotary engines are less attractive, requiring from 10 percent to 80 percent more aircraft to have the same total payload capability as a given number of turbine powered craft. A nomogram was developed for estimating total costs of engines not covered in this study.

  6. 26 CFR 301.6103(p)(2)(B)-1 - Disclosure of returns and return information by other agencies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... other agencies. 301.6103(p)(2)(B)-1 Section 301.6103(p)(2)(B)-1 Internal Revenue INTERNAL REVENUE... Information and Returns Returns and Records § 301.6103(p)(2)(B)-1 Disclosure of returns and return information... regulations thereunder, including, if applicable, safeguards imposed by section 6103(p)(4). (d) Records...

  7. 26 CFR 301.6103(p)(2)(B)-1 - Disclosure of returns and return information by other agencies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... other agencies. 301.6103(p)(2)(B)-1 Section 301.6103(p)(2)(B)-1 Internal Revenue INTERNAL REVENUE... Information and Returns Returns and Records § 301.6103(p)(2)(B)-1 Disclosure of returns and return information... regulations thereunder, including, if applicable, safeguards imposed by section 6103(p)(4). (d) Records...

  8. 26 CFR 301.6103(p)(2)(B)-1 - Disclosure of returns and return information by other agencies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... other agencies. 301.6103(p)(2)(B)-1 Section 301.6103(p)(2)(B)-1 Internal Revenue INTERNAL REVENUE... Information and Returns Returns and Records § 301.6103(p)(2)(B)-1 Disclosure of returns and return information... regulations thereunder, including, if applicable, safeguards imposed by section 6103(p)(4). (d) Records...

  9. 26 CFR 301.6103(p)(2)(B)-1 - Disclosure of returns and return information by other agencies.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... other agencies. 301.6103(p)(2)(B)-1 Section 301.6103(p)(2)(B)-1 Internal Revenue INTERNAL REVENUE... Information and Returns Returns and Records § 301.6103(p)(2)(B)-1 Disclosure of returns and return information... regulations thereunder, including, if applicable, safeguards imposed by section 6103(p)(4). (d) Records...

  10. 26 CFR 301.6103(p)(2)(B)-1 - Disclosure of returns and return information by other agencies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... other agencies. 301.6103(p)(2)(B)-1 Section 301.6103(p)(2)(B)-1 Internal Revenue INTERNAL REVENUE... Information and Returns Returns and Records § 301.6103(p)(2)(B)-1 Disclosure of returns and return information... regulations thereunder, including, if applicable, safeguards imposed by section 6103(p)(4). (d) Records...

  11. Nematode and Arthropod Genomes Provide New Insights into the Evolution of Class 2 B1 GPCRs

    PubMed Central

    Cardoso, João C. R.; Félix, Rute C.; Power, Deborah M.

    2014-01-01

    Nematodes and arthropods are the most speciose animal groups and possess Class 2 B1 G-protein coupled receptors (GPCRs). Existing models of invertebrate Class 2 B1 GPCR evolution are mainly centered on Caenorhabditis elegans and Drosophila melanogaster and a few other nematode and arthropod representatives. The present study reevaluates the evolution of metazoan Class 2 B1 GPCRs and orthologues by exploring the receptors in several nematode and arthropod genomes and comparing them to the human receptors. Three novel receptor phylogenetic clusters were identified and designated cluster A, cluster B and PDF-R-related cluster. Clusters A and B were identified in several nematode and arthropod genomes but were absent from D. melanogaster and Culicidae genomes, whereas the majority of the members of the PDF-R-related cluster were from nematodes. Cluster A receptors were nematode and arthropod-specific but shared a conserved gene environment with human receptor loci. Cluster B members were orthologous to human GCGR, PTHR and Secretin members with which they probably shared a common origin. PDF-R and PDF-R related clusters were present in representatives of both nematodes and arthropods. The results of comparative analysis of GPCR evolution and diversity in protostomes confirm previous notions that C. elegans and D. melanogaster genomes are not good representatives of nematode and arthropod phyla. We hypothesize that at least four ancestral Class 2 B1 genes emerged early in the metazoan radiation, which after the protostome-deuterostome split underwent distinct selective pressures that resulted in duplication and deletion events that originated the current Class 2 B1 GPCRs in nematode and arthropod genomes. PMID:24651821

  12. D-558-2 being mounted to P2B-1S launch aircraft in hangar

    NASA Technical Reports Server (NTRS)

    1954-01-01

    This 1954 photograph shows a Douglas D-558-2 under the P2B-1S (Navy designation for a B-29) launch aircraft. The P2B-1S has been lifted on mechanical jacks in the hangar for a possible 'fit check' or the attachment of the Skyrocket for a flight. The P2B-1S had the nickname 'Fertile Myrtle.' On the side of its fuselage is a series of images indicating 41 launches by the mothership of D-558-2 #2 (NACA 144) and 44 by D-558-2 #3 (NACA 145). The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and XF-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS); the Navy-Marine Corps; and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service aircraft of that era, particularly at low speeds

  13. D-558-2 being mounted to P2B-1S launch aircraft

    NASA Technical Reports Server (NTRS)

    1953-01-01

    This 1953 NACA High-Speed Flight Research Station photograph shows the Douglas D-558-2 #2 Skyrocket (NACA 144), prior to flight, being towed under the P2B-1S launch vehicle (NACA 137) for attachment. The photograph also shows the large hydraulic jacks used to elevate the P2B-1S launch vehicle. Once the D-558-2 was in position, the P2B-1S would be lowered and the attachment made. The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and X-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS); the Navy-Marine Corps; and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service aircraft of that era, particularly at low speeds during take-off and landing and in tight turns. The three

  14. D-558-2 being mounted to P2B-1S launch aircraft

    NASA Technical Reports Server (NTRS)

    1953-01-01

    This 1953 NACA High-Speed Flight Research Station photograph shows the Douglas D-558-2 #2 Skyrocket (NACA 144), prior to flight, being towed under the P2B-1S (Navy designation for the Air Force B-29) launch vehicle (NACA 137) for attachment. In this view the tail of the Skyrocket is almost aligned with the opening cut to fit in the bottom of the P2B-1S. The photograph also shows the large hydraulic jacks used to elevate the P2B-1S launch vehicle. The Douglas D-558-2 'Skyrockets' were among the early transonic research airplanes like the X-1, X-4, X-5, and X-92A. Three of the single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA), with its flight research done at the NACA's Muroc Flight Test Unit in Calif., redesignated in 1949 the High-Speed Flight Research Station (HSFRS). Also partners in the flight research were the Navy-Marine Corps and the Douglas Aircraft Co. The HSFRS became the High-Speed Flight Station in 1954 and is now known as the NASA Dryden Flight Research Center. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. The 2 in the aircraft's designation referred to the fact that the Skyrocket was the phase-two version of what had originally been conceived as a three-phase program, with the phase-one aircraft having straight wings. The third phase, which never came to fruition, would have involved constructing a mock-up of a combat-type aircraft embodying the results from the testing of the phase one and two aircraft. Douglas pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in Calif. on February 4, 1948. The goals of the program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitch-up (uncommanded rotation of the nose of the airplane upwards)--a problem prevalent in high-speed service

  15. Hydroxysteroid Sulfotransferase SULT2B1b Promotes Hepatocellular Carcinoma Cells Proliferation In Vitro and In Vivo

    PubMed Central

    Yang, Xiaoming; Xu, Yali; Guo, Fenghua; Ning, Yanxia; Zhi, Xiuling; Yin, Lianhua; Li, Xiaobo

    2013-01-01

    Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) is highly selective for the addition of sulfate groups to 3β-hydroxysteroids. Although previous reports have suggested that SULT2B1b is correlated with cell proliferation of hepatocytes, the relationship between SULT2B1b and the malignant phenotype of hepatocarcinoma cells was not clear. In the present study, we found that SULT2B1 was comparatively higher in the human hepatocarcinoma tumorous tissues than their adjacent tissues. Besides, SULT2B1b overexpression promoted the growth of the mouse hepatocarcinoma cell line Hepa1-6, while Lentivirus-mediated SULT2B1b interference inhibited growth as assessed by the CCK-8 assay. Likewise, inhibition of SULT2B1b expression induced cell-cycle arrest and apoptosis in Hepa1-6 cells by upregulating the expression of FAS, downregulating the expression of cyclinB1, BCL2 and MYC in vitro and in vivo at both the transcript and protein levels. Knock-down of SULT2B1b expression significantly suppressed tumor growth in nude mouse xenografts. Moreover, proliferation rates and SULT2B1b expression were highly correlated in the human hepatocarcinoma cell lines Huh-7, Hep3B, SMMC-7721 and BEL-7402 cells. Knock-down of SULT2B1b inhibited cell growth and cyclinB1 levels in human hepatocarcinoma cells and suppressed xenograft growth in vivo. In conclusion, SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of HCC. PMID:23593328

  16. 76 FR 80228 - Airworthiness Directives; Turbomeca Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... August 31, 2011 (76 FR 54143). That NPRM proposed to correct an unsafe condition for the specified... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive or... unsafe condition as an increase in hot gas ingestion and an increase of temperature in the gas...

  17. 76 FR 67594 - Airworthiness Directives; General Electric Company Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-02

    ... Executive Order 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR..., phone: (513) 552- 3272; email: geae.aoc@ge.com . You may review copies of the service information at the..., phone: (513) 552-3272; email: geae.aoc@ge.com . (4) You may review copies of the service information...

  18. Common Variants in the ATP2B1 Gene Are Associated With Susceptibility to Hypertension

    PubMed Central

    Tabara, Yasuharu; Kohara, Katsuhiko; Kita, Yoshikuni; Hirawa, Nobuhito; Katsuya, Tomohiro; Ohkubo, Takayoshi; Hiura, Yumiko; Tajima, Atsushi; Morisaki, Takayuki; Miyata, Toshiyuki; Nakayama, Tomohiro; Takashima, Naoyuki; Nakura, Jun; Kawamoto, Ryuichi; Takahashi, Norio; Hata, Akira; Soma, Masayoshi; Imai, Yutaka; Kokubo, Yoshihiro; Okamura, Tomonori; Tomoike, Hitonobu; Iwai, Naoharu; Ogihara, Toshio; Inoue, Itsuro; Tokunaga, Katsushi; Johnson, Toby; Caulfield, Mark; Munroe, Patricia; Umemura, Satoshi; Ueshima, Hirotsugu; Miki, Tetsuro

    2016-01-01

    Hypertension is one of the most common complex genetic disorders. We have described previously 38 single nucleotide polymorphisms (SNPs) with suggestive association with hypertension in Japanese individuals. In this study we extend our previous findings by analyzing a large sample of Japanese individuals (n=14 105) for the most associated SNPs. We also conducted replication analyses in Japanese of susceptibility loci for hypertension identified recently from genome-wide association studies of European ancestries. Association analysis revealed significant association of the ATP2B1 rs2070759 polymorphism with hypertension (P=5.3×10−5; allelic odds ratio: 1.17 [95% CI: 1.09 to 1.26]). Additional SNPs in ATP2B1 were subsequently genotyped, and the most significant association was with rs11105378 (odds ratio: 1.31 [95% CI: 1.21 to 1.42]; P=4.1×10−11). Association of rs11105378 with hypertension was cross-validated by replication analysis with the Global Blood Pressure Genetics consortium data set (odds ratio: 1.13 [95% CI: 1.05 to 1.21]; P=5.9×10−4). Mean adjusted systolic blood pressure was highly significantly associated with the same SNP in a meta-analysis with individuals of European descent (P=1.4×10−18). ATP2B1 mRNA expression levels in umbilical artery smooth muscle cells were found to be significantly different among rs11105378 genotypes. Seven SNPs discovered in published genome-wide association studies were also genotyped in the Japanese population. In the combined analysis with replicated 3 genes, FGF5 rs1458038, CYP17A1, rs1004467, and CSK rs1378942, odds ratio of the highest risk group was 2.27 (95% CI: 1.65 to 3.12; P=4.6×10−7) compared with the lower risk group. In summary, this study confirmed common genetic variation in ATP2B1, as well as FGF5, CYP17A1, and CSK, to be associated with blood pressure levels and risk of hypertension. PMID:20921432

  19. Preparation, Purification, and Identification of a Monoclonal Antibody Against NRP2 b1b2 Domain.

    PubMed

    Yang, Yun; Chen, Na; Li, Zhe; Wang, Xian-Jiang; Wang, Sheng-Yu; Tingwu; Luo, Fang-Hong; Yan, Jiang-Hua

    2015-10-01

    First identified as a high-affinity kinase-deficient receptor for class-3 semaphorins and vascular endothelial growth factor (VEGF) families, Neuropilin2 (NRP2) is a transmembrane non-tyrosine-kinase glycoprotein that has a vital function in neuronal patterning. Furthermore, NRP2 expression is often upregulated in cancer tissues and correlated with poor prognosis. In the present study, we report the establishment of a monoclonal antibody specific for NRP2b1b2 domain (NRP2 MAb) through hybridoma method. NRP2 MAb is measured to have a titer of 5.12 × 10(5) against NRP2b1b2 in indirect ELISA. Western blotting, flow cytometry, and immunofluorescence analysis indicate that NRP2 MAb can combine full-length NRP2 in LoVo and SW480 cells. Besides helping further understand NRP2-related pathological mechanisms and cell-signaling pathways, NRP2 MAb may act as a therapeutic agent for cancer in the future. PMID:26492624

  20. D-558-2 pilot entry from P2B-1S mothership

    NASA Technical Reports Server (NTRS)

    1954-01-01

    This 28-second video clip shows Scott Crossfield descending from the bomb bay of the P2B-1S into the cockpit of the D-558-2, strapping in, and having the hatch closed by a crewmember. The Douglas D-558-2 Skyrocket airplanes were among the early transonic research airplanes like the X-1, X-4, X-5, and X-92A. Three of these single-seat, swept-wing aircraft flew from 1948 to 1956 in a joint program involving the National Advisory Committee for Aeronautics (NACA); the Navy-Marine Corps; and the Douglas Aircraft Company, Long Beach, California. Flight research was done at the NACA Muroc Flight Test Unit in California, redesignated in 1949 the High-Speed Flight Research Station (HSFRS). The HSFRS is now known as the NASA Dryden Flight Research Center, Edwards, California. The Skyrocket made aviation history when it became the first airplane to fly twice the speed of sound. Douglas Aircraft pilot John F. Martin made the first flight at Muroc Army Airfield (later renamed Edwards Air Force Base) in California on February 4, 1948. The goals of that program were to investigate the characteristics of swept-wing aircraft at transonic and supersonic speeds with particular attention to pitchup (uncommanded rotation of the nose of the airplane upwards) -- a problem prevalent in high-speed service aircraft of that era, particularly at low speeds during takeoff and landing and in tight turns. The three aircraft gathered a great deal of data about pitchup and the coupling of lateral (yaw) and longitudinal (pitch) motions; wing and tail loads, lift, drag, and buffeting characteristics of swept-wing aircraft at transonic and supersonic speeds; and the effects of the rocket exhaust plume on lateral dynamic stability throughout the speed range. (Plume effects were a new experience for aircraft.) The number three aircraft also gathered information about the effects of external stores (bomb shapes, drop tanks) upon the aircraft behavior in the transonic region (roughly 0.7 to 1.3 times the

  1. Laboratory detection of a new interstellar free radical CH2CN(2B1)

    NASA Technical Reports Server (NTRS)

    Saito, Shuji; Yamamoto, Satoshi; Irvine, W. M.; Ziurys, L. M.; Suzuki, Hiroko

    1988-01-01

    An asymmetric-top free radical CH2CN with a 2B1 ground state was detected by laboratory microwave spectroscopy. The radical was produced in a free-space absorption cell by a DC glow discharge in pure CH3CN gas. About 60 fine-structure components were observed for the N = 11-10 to 14-13 a-type rotational transitions in the frequency region of 220-260 GHz. Hyperfine resolved components for the N = 4-3 and 5-4 transitions were resolved in the 80 and 100 GHz regions, respectively. Molecular constants were determined and U100602 and U80484 from Sgr B2, and U40240 and U20120 from TMC-1 were assigned to the N = 5-4, 4-3, 2-1, and 1-0 transitions with K(-1) = 0 of the CH2CN radical.

  2. The Design and Testing of a Miniature Turbofan Engine

    NASA Technical Reports Server (NTRS)

    Cosentino, Gary B.; Murray, James E.

    2009-01-01

    Off-the-shelf jet propulsion in the 50 - 500 lb thrust class sparse. A true twin-spool turbofan in this range does not exist. Adapting an off-the-shelf turboshaft engine is feasible. However the approx.10 Hp SPT5 can t quite make 50 lbs. of thrust. Packaging and integration is challenging, especially the exhaust. Building on our engine using a 25 Hp turboshaft seems promising if the engine becomes available. Test techniques used, though low cost, adequate for the purpose.

  3. Heterogeneous Nuclear Ribonucleoprotein A2/B1 as a Target Antigen in Han Chinese for BD Patients.

    PubMed

    Liang, Jinghui; Yang, Weikang; Meng, Xiangyu; Chen, Peng; Du, Hongwu

    2015-01-01

    Behcet's disease (BD) is a recurrent pathema with a typical symptom of inflammation involved in many organs. Previous report indicated that the serum of Korean patients with BD stimulates membrane expression of hnRNP A2/B1 in endothelial cells. In this study, the target 35 kDa recombinant human hnRNP A2/B1 were over-expressed and purified, then sequenced with MALDI-TOF- TOF mass spectrometry. Western blotting and ELISA were applied to detect serum reactivity against hnRNP A2/B1 respectively. The results demonstrate that hnRNP A2/B1 is an autoantigen of BD in Han Chinese population. PMID:25925770

  4. Test stand performance of a convertible engine for advanced V/STOL and rotorcraft propulsion

    NASA Technical Reports Server (NTRS)

    Mcardle, Jack G.

    1987-01-01

    A variable inlet guide vane (VIGV) convertible engine that could be used to power future high-speed V/STOL and rotorcraft was tested on an outdoor stand. The engine ran stably and smoothly in the turbofan, turboshaft, and dual (combined fan and shaft) power modes. In the turbofan mode with the VIGV open, fuel consumption was comparable to that of a conventional turbofan engine. In the turboshaft mode with the VIGV closed, fuel consumption was higher than that of present turboshaft engines because power was wasted in churning fan-tip air flow. In dynamic performance tests with a specially built digital engine control and using a waterbrake dynamometer for shaft load, the engine responded effectively to large steps in thrust command and shaft torque.

  5. Yields of O2(b 1 Sigma g +) from reactions of HO2. [in planetary atmospheres

    NASA Technical Reports Server (NTRS)

    Keyser, L. F.; Choo, K. Y.; Leu, M. T.

    1985-01-01

    The production of O2(b 1 Sigma g +) has been monitored for several reactions of the HO2 radical at 300 K using a discharge-flow apparatus with resonance fluorescence and chemiluminescence detection. In all cases, the resulting quantum efficiencies were found to be less than 0.03. O2(b) was observed when F atoms were added to H2O2 in the gas phase. The signal strengths of O2(b) were proportional to initial concentrations of HO2 formed by the F + H2O2 reaction. Observed /O2(b)/, /HO2/, and /OH/ vs /F/0 were analyzed using a simple three-step mechanism and a more complete computer simulation with 22 reaction steps. The results indicate that the F + HO2 reaction yields O2(b) with an efficiency of (3.6 + or - 1.4) x 10 to the -3rd. Yields from the O + OH2 reaction were less than 0.02, indicating that this reaction cannot be a major source of the O2(b) emission observed in the earth's nightglow.

  6. Laboratory detection of a new interstellar free radical CH2CN(2B1).

    PubMed

    Saito, S; Yamamoto, S; Irvine, W M; Ziurys, L M; Suzuki, H; Ohishi, M; Kaifu, N

    1988-11-15

    An asymmetric-top free radical CH2CN, which as a 2B1 ground state, was detected for the first time by laboratory microwave spectroscopy. The radical was produced in a free-space absorption cell by a DC glow discharge in pure CH3CN gas. About 60 fine-structure components were observed for the N = 11-10 to 14-13 a-type rotational transitions in the frequency region of 220-260 GHz, and many hyperfine resolved components for the N = 4-3 and 5-4 transitions in the 80 and 100 GHz regions, respectively. The molecular constants, including the rotational constants, centrifugal distortion constants, and spin-rotation coupling constants with centrifugal distortion correction terms were determined from the fine-structure resolved transitions, and the hyperfine coupling constants due to the hydrogen and nitrogen nuclei were obtained from the low-N transitions. As a result we assigned U100602 and U80484 from Sgr B2, and U40240 and U20120 from TMC-1, to the N = 5-4, 4-3, 2-1, and 1-0 transitions with K-1 = 0 of the CH2CN radical. PMID:11538464

  7. Microwave Spectrum of the PD2 Radical in the 2B1 Ground Electronic State

    PubMed

    Hirao; Hayakashi; Yamamoto; Saito

    1998-02-01

    The rotational spectrum of the PD2 radical in the 2B1 ground electronic state was observed in the region 165-463 GHz using a source-modulated microwave spectrometer. The PD2 radical was generated in a free-space absorption cell by a dc glow discharge of D2 over red phosphorus grains which were placed in the middle of the Pyrex glass cell. One hundred thirty fine and hyperfine components of 20 b-type rotational transitions were measured and analyzed by least-squares methods. The rotational and centrifugal distortion constants, the spin-rotation coupling constants with their centrifugal distortion terms, and the hyperfine coupling constants of both the phosphorus and the deuterium nuclei were precisely determined. The phosphorus nuclear spin-rotation coupling constants were found to have relatively large values: Caa(P) = 0.4815(89) MHz, Cbb(P) = 0.2501 (104) MHz, and Ccc(P) = 0.0564 (74) MHz, as suggested from those of PH2. The harmonic force field of PH2 was derived from centrifugal distortion constants, inertial defects, and the reported vibrational frequencies for PH2 and PD2. The determined force field was used to make harmonic corrections to the observed moments of inertia, and the rz structures for both species were derived,PH2: rz(PH) = 1.43365(23) A, thetaz(HPH) = 91.622(32)degreesandPD2: rz(PD) = 1.42852(17) A, thetaz(DPD) = 91.646(23)degrees,where errors in parentheses are due to residual inertial defects of the corrected moments of inertia. Copyright 1998 Academic Press. Copyright 1998Academic Press PMID:9473433

  8. HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events.

    PubMed

    Alarcón, Claudio R; Goodarzi, Hani; Lee, Hyeseung; Liu, Xuhang; Tavazoie, Saeed; Tavazoie, Sohail F

    2015-09-10

    N(6)-methyladenosine (m(6)A) is the most abundant internal modification of messenger RNA. While the presence of m(6)A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates processing of nuclear transcripts has not been identified. We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-bearing RNAs in vivo and in vitro and its biochemical footprint matches the m(6)A consensus motif. HNRNPA2B1 directly binds a set of nuclear transcripts and elicits similar alternative splicing effects as the m(6)A writer METTL3. Moreover, HNRNPA2B1 binds to m(6)A marks in a subset of primary miRNA transcripts, interacts with the microRNA Microprocessor complex protein DGCR8, and promotes primary miRNA processing. Also, HNRNPA2B1 loss and METTL3 depletion cause similar processing defects for these pri-miRNA precursors. We propose HNRNPA2B1 to be a nuclear reader of the m(6)A mark and to mediate, in part, this mark's effects on primary microRNA processing and alternative splicing. PAPERCLIP. PMID:26321680

  9. Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery.

    PubMed

    Hussner, Janine; Begunk, Robert; Boettcher, Kerstin; Gliesche, Daniel G; Prestin, Katharina; Meyer Zu Schwabedissen, Henriette E

    2015-09-01

    Clinical success of coronary drug-eluting stents (DES) is hampered by simultaneous reduction of smooth muscle cell (HCASMC) and endothelial cell proliferation due to unspecific cytotoxicity of currently used compounds. Previous in vitro data showing SMC-specific inhibition of proliferation suggested that statins may be suitable candidates for DES. It was aim of this study to further investigate statins as DES drug candidates to identify mechanisms contributing to their cell-selectivity. In vitro proliferation assays comparing the influence of various statins on HCASMC and endothelial cells confirmed that atorvastatin exhibits HCASMC-specificity. Due to similar expression levels of the drug target HMG-CoA reductase in both cell types, cellular accumulation of atorvastatin was assessed, revealing enhanced uptake in HCASMC most likely driven by significant expression of OATP2B1, a known uptake transporter for atorvastatin. In accordance with the finding that endogenous OATP2B1 influenced cellular accumulation in HCASMC we used this transporter as a tool to identify teniposide as new DES candidate drug with HCASMC-specific effects. We describe OATP2B1 as a determinant of pharmacokinetics in the coronary artery. Indeed, endogenously expressed OATP2B1 significantly influences the uptake of substrate drugs, thereby governing cell specificity. Screening of candidate drugs for interaction with OATP2B1 may be used to promote SMC-specificity. PMID:26091578

  10. Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy.

    PubMed

    Li, Songqing; Zhang, Peipei; Freibaum, Brian D; Kim, Nam Chul; Kolaitis, Regina-Maria; Molliex, Amandine; Kanagaraj, Anderson P; Yabe, Ichiro; Tanino, Mishie; Tanaka, Shinya; Sasaki, Hidenao; Ross, Eric D; Taylor, J Paul; Kim, Hong Joo

    2016-03-01

    Adult-onset inherited myopathies with similar pathological features, including hereditary inclusion body myopathy (hIBM) and limb-girdle muscular dystrophy (LGMD), are a genetically heterogeneous group of muscle diseases. It is unclear whether these inherited myopathies initiated by mutations in distinct classes of genes are etiologically related. Here, we exploit a genetic model system to establish a mechanistic link between diseases caused by mutations in two distinct genes, hnRNPA2B1 and DNAJB6. Hrb98DE and mrj are the Drosophila melanogaster homologs of human hnRNPA2B1 and DNAJB6, respectively. We introduced disease-homologous mutations to Hrb98DE, thus capturing mutation-dependent phenotypes in a genetically tractable model system. Ectopic expression of the disease-associated mutant form of hnRNPA2B1 or Hrb98DE in fly muscle resulted in progressive, age-dependent cytoplasmic inclusion pathology, as observed in humans with hnRNPA2B1-related myopathy. Cytoplasmic inclusions consisted of hnRNPA2B1 or Hrb98DE protein in association with the stress granule marker ROX8 and additional endogenous RNA-binding proteins (RBPs), suggesting that these pathological inclusions are related to stress granules. Notably, TDP-43 was also recruited to these cytoplasmic inclusions. Remarkably, overexpression of MRJ rescued this phenotype and suppressed the formation of cytoplasmic inclusions, whereas reduction of endogenous MRJ by a classical loss of function allele enhanced it. Moreover, wild-type, but not disease-associated, mutant forms of MRJ interacted with RBPs after heat shock and prevented their accumulation in aggregates. These results indicate both genetic and physical interactions between disease-linked RBPs and DNAJB6/mrj, suggesting etiologic overlap between the pathogenesis of hIBM and LGMD initiated by mutations in hnRNPA2B1 and DNAJB6. PMID:26744327

  11. HNRNPA2B1 is a mediator of m6A-dependent nuclear RNA processing events

    PubMed Central

    Alarcón, Claudio R.; Goodarzi, Hani; Lee, Hyeseung; Liu, Xuhang; Tavazoie, Saeed; Tavazoie, Sohail F.

    2015-01-01

    SUMMARY N6-methyladenosine (m6A) is the most abundant internal modification of messenger RNA. While the presence of m6A on transcripts can impact alternative splicing, a nuclear reader of this mark that mediates the processing of nuclear transcripts has not been identified. We find that the RNA-binding HNRNPA2B1 protein binds m6A-bearing RNAs in vivo and in vitro and its biochemical footprint matches the m6A consensus motif. HNRNPA2B1 directly binds a set of nuclear transcripts and modulates their alternative splicing in a similar manner as the m6A ‘writer’ METTL3. Moreover, HNRNPA2B1 binds to m6A marks in a subset of primary-miRNA transcripts, interacts with the microRNA Microprocessor complex protein DGCR8, and promotes primary miRNA processing—phenocopying the effect of METTL3 depletion on the processing of these precursor transcripts. We propose HNRNPA2B1 to be a nuclear reader of the m6A mark and to mediate, in part, this mark’s effects on primary microRNA processing and alternative splicing. PMID:26321680

  12. General Aviation Turbine Engine (GATE) study

    NASA Technical Reports Server (NTRS)

    Baerst, C. F.; Furst, D. G.

    1979-01-01

    The feasibility of turbine engines for the smaller general aviation aircraft was investigated and a technology program for developing the necessary technology was identified. Major results included the definition of the 1988 general aviation market, the identification of turboprop and turboshaft engines that meet the requirements of the aircraft studies, a benefit analysis showing the superiority of gas turbine engines for portions of the market studied, and detailed plans for the development of the necessary technology.

  13. 2,6-Diphenylthiazolo[3,2-b][1,2,4]triazoles as telomeric G-quadruplex stabilizers.

    PubMed

    El Bakali, Jamal; Klupsch, Frédérique; Guédin, Aurore; Brassart, Bertrand; Fontaine, Gaëlle; Farce, Amaury; Roussel, Pascal; Houssin, Raymond; Bernier, Jean-Luc; Chavatte, Philippe; Mergny, Jean-Louis; Riou, Jean-François; Hénichart, Jean-Pierre

    2009-07-01

    The design and synthesis of 2,6-diphenylthiazolo[3,2-b][1,2,4]triazoles characterized by a large aromatic building block bearing cationic side chains are reported. These molecules are evaluated as telomeric G-quadruplex stabilizers and for their selectivity towards duplex DNA by competition experiments. Two compounds (14a, 19) were found active with high selectivity for telomeric G-quadruplex over duplex DNA. PMID:19473838

  14. Site-Directed Mutagenesis of Human Cytosolic Sulfotransferase (SULT) 2B1b to Phospho-mimetic Ser348Asp Results in an Isoform With Increased Catalytic Activity

    PubMed Central

    Salman, Emily D.; He, Dongning; Runge-Morris, Melissa; Kocarek, Thomas A.; Falany, Charles N.

    2011-01-01

    Human SULT2B1b is distinct from other SULT isoforms due to the presence of unique amino (N)- and carboxy (C)-terminal peptides. Using site-directed mutagenesis, it was determined that phosphorylation of Ser348 was associated with nuclear localization. To investigate the effects of this phosphorylation of Ser348 on activity and cellular localization, an in silico molecular mimic was generated by mutating Ser348 to an Asp. The Asp residue mimics the shape and charge of a phospho-Ser and homology models of SULT2B1b-phospho-S348 and SULT2B1b-S348D suggest a similar significant structural rearrangement in the C-terminal peptide. To evaluate the functional consequences of this post-translational modification and predicted rearrangement, 6His-SULT2B1b-S348D was synthesized, expressed, purified and characterized. The 6His-SULT2B1b-S348D has a specific activity for DHEA sulfation ten-fold higher than recombinant 6His-SULT2B1b (209.6 and 21.8 pmol·min−1·mg−1, respectively). Similar to native SULT2B1b, gel filtration chromatography showed SULT2B1b-S348D was enzymatically active as a homodimer. Stability assays comparing SULT2B1b and SUL2B1b-S348 demonstrated that SULT2B1b is 60% less thermostable than SULT2B1b-348D. The increased stability and sulfation activity allowed for better characterization of the sulfation kinetics for putative substrates as well as the determination of dissociation constants that were difficult to obtain with wild-type (WT) 6His-SULT2B1b. The KDs for DHEA and PAPS binding to 6His-SULT2B1b-S348D were 650 ± 7 nM and 265 ± 4 nM, respectively, whereas KDs for binding of substrates to the WT enzyme could not be determined. Characterization of the molecular mimic SULT2B1b-S348D provides a better understanding for the role of the unique structure of SULT2B1b and its effect on sulfation activity, and has allowed for improved kinetic characterization of the SULT2B1b enzyme. PMID:21855633

  15. Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma

    PubMed Central

    Hu, Liang; Yang, Guang-Zhen; Zhang, Yu; Feng, Dan; Zhai, Yan-Xia; Gong, Hui; Qi, Chen-Ye; Fu, Hao; Ye, Ming-Ming; Cai, Qing-Ping; Gao, Chun-Fang

    2015-01-01

    Aberrant expression of cytosolic sulfotransferase 2B1b (SULT2B1b) has been reported in several human malignancies. However, the expression pattern and clinical significance of SULT2B1b in colorectal carcinoma (CRC) remains unknown. Real-time quantitative PCR, western blot, and immunohistochemistry analyses were used to determine SULT2B1b expression in CRC clinical samples and CRC-derived cell lines. Kaplan–Meier and Cox proportional regression analyses were used to evaluate the association between SULT2B1b expression and patient survival in two independent cohorts of 485 patients with CRC. Gain- and loss-of-function approaches were employed to investigate the role of SULT2B1b in regulation of CRC cell growth and invasion. We found that SULT2B1b expression was frequently upregulated in CRC clinical samples and CRC-derived cell lines and was significantly correlated with lymph node metastasis and TNM stage in both the training and validation cohorts. Patients with higher intratumoral SULT2B1b expression had a significantly shorter disease-specific survival (DSS) and disease-free survival (DFS) than those with lower expression. Importantly, increased expression of SULT2B1b significantly predicted poor DSS and DFS and was an independent unfavorable prognostic indicator for stage II patients in both cohorts. Functional studies revealed that overexpression of SULT2B1b promoted CRC cell growth and invasion in vitro. Conversely, knockdown of SULT2B1b inhibited these processes. In conclusion, our findings suggest that SULT2B1b expression correlates with disease progression and metastasis and may serve as a novel prognostic biomarker and potential therapeutic target for patients with CRC. PMID:26121319

  16. SULT2B1b Sulfotransferase: Induction by Vitamin D Receptor and Reduced Expression in Prostate Cancer

    PubMed Central

    Seo, Young-Kyo; Mirkheshti, Nooshin; Song, Chung S.; Kim, Soyoung; Dodds, Sherry; Ahn, Soon C.; Christy, Barbara; Mendez-Meza, Rosario; Ittmann, Michael M.; Abboud-Werner, Sherry

    2013-01-01

    An elevated tumor tissue androgen level, which reactivates androgen receptor in recurrent prostate cancer, arises from the intratumor synthesis of 5α-dihydrotestosterone through use of the precursor steroid dehydroepiandrosterone (DHEA) and is fueled by the steroidogenic enzymes 3β-hydroxysteroid dehydrogenase (3β-HSD1), aldoketoreductase (AKR1C3), and steroid 5-alpha reductase, type 1 (SRD5A1) present in cancer tissue. Sulfotransferase 2B1b (SULT2B1b) (in short, SULT2B) is a prostate-expressed hydroxysteroid SULT that converts cholesterol, oxysterols, and DHEA to 3β-sulfates. DHEA metabolism involving sulfonation by SULT2B can potentially interfere with intraprostate androgen synthesis due to reduction of free DHEA pool and, thus, conversion of DHEA to androstenedione. Here we report that in prostatectomy specimens from treatment-naive patients, SULT2B expression is markedly reduced in malignant tissue (P < .001, Mann-Whitney U test) compared with robust expression in adjacent nonmalignant glands. SULT2B was detected in formalin-fixed specimens by immunohistochemistry on individual sections and tissue array. Immunoblotting of protein lysates of frozen cancer and matched benign tissue confirmed immunohistochemistry results. An in-house–developed rabbit polyclonal antibody against full-length human SULT2B was validated for specificity and used in the analyses. Ligand-activated vitamin D receptor induced the SULT2B1 promoter in vivo in mouse prostate and increased SULT2B mRNA and protein levels in vitro in prostate cancer cells. A vitamin D receptor/retinoid X receptor-α–bound DNA element (with a DR7 motif) mediated induction of the transfected SULT2B1 promoter in calcitriol-treated cells. SULT2B knockdown caused an increased proliferation rate of prostate cancer cells upon stimulation by DHEA. These results suggest that the tumor tissue SULT2B level may partly control prostate cancer growth, and its induction in a therapeutic setting may inhibit disease

  17. High-Speed Multiprocessing For Engine Simulation

    NASA Technical Reports Server (NTRS)

    Milner, Edward J.; Arpasi, Dale J.

    1988-01-01

    Parallel microprocessors have computational power and speed for realistic simulations. Interactive information bus links front-end processor and computational processors. Real-time information bus links real-time extension processor and pre-processors. Computational processor and preprocessor communicate through shared memory. System used to simulate small turboshaft engine to demonstrate potential of multiprocessing in such applications. Real-time simulations aid development of new digital engine controls enabling testing of hardware and software under realistic conditions.

  18. A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver.

    PubMed

    Prabhu, L; Upadhya, P; Ram, N; Nirodi, C S; Sultana, S; Vatsala, P G; Mani, S A; Rangarajan, P N; Surolia, A; Padmanaban, G

    1995-10-10

    The phenobarbitone-responsive minimal promoter has been shown to lie between nt -179 and nt + 1 in the 5' (upstream) region of the CYP2B1/B2 gene in rat liver, on the basis of the drug responsiveness of the sequence linked to human growth hormone gene as reporter and targeted to liver as an asialoglycoprotein-DNA complex in vivo. Competition analyses of the nuclear protein-DNA complexes formed in gel shift assays with the positive (nt -69 to -98) and negative (nt -126 to -160) cis elements (PE and NE, respectively) identified within this region earlier indicate that the same protein may be binding to both the elements. The protein species purified on PE and NE affinity columns appear to be identical based on SDS/PAGE analysis, where it migrates as a protein of 26-28 kDa. Traces of a high molecular weight protein (94-100 kDa) are also seen in the preparation obtained after one round of affinity chromatography. The purified protein stimulates transcription of a minigene construct containing the 179 nt on the 5' side of the CYP2B1/B2 gene linked to the I exon in a cell-free system from liver nuclei. The purified protein can give rise to all the three complexes (I, II, and III) with the PE, just as the crude nuclear extract, under appropriate conditions. Manipulations in vitro indicate that the NE has a significantly higher affinity for the dephosphorylated form than for the phosphorylated form of the protein. The PE binds both forms. Phenobarbitone treatment of the animal leads to a significant increase in the phosphorylation of the 26- to 28-kDa and 94-kDa proteins in nuclear labeling experiments followed by isolation on a PE affinity column. We propose that the protein binding predominantly to the NE in the dephosphorylated state characterizes the basal level of transcription of the CYP2B1/B2 gene. Phenobarbitone treatment leads to phosphorylation of the protein, shifting the equilibrium toward binding to the PE. This can promote interaction with an upstream

  19. A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver.

    PubMed Central

    Prabhu, L; Upadhya, P; Ram, N; Nirodi, C S; Sultana, S; Vatsala, P G; Mani, S A; Rangarajan, P N; Surolia, A; Padmanaban, G

    1995-01-01

    The phenobarbitone-responsive minimal promoter has been shown to lie between nt -179 and nt + 1 in the 5' (upstream) region of the CYP2B1/B2 gene in rat liver, on the basis of the drug responsiveness of the sequence linked to human growth hormone gene as reporter and targeted to liver as an asialoglycoprotein-DNA complex in vivo. Competition analyses of the nuclear protein-DNA complexes formed in gel shift assays with the positive (nt -69 to -98) and negative (nt -126 to -160) cis elements (PE and NE, respectively) identified within this region earlier indicate that the same protein may be binding to both the elements. The protein species purified on PE and NE affinity columns appear to be identical based on SDS/PAGE analysis, where it migrates as a protein of 26-28 kDa. Traces of a high molecular weight protein (94-100 kDa) are also seen in the preparation obtained after one round of affinity chromatography. The purified protein stimulates transcription of a minigene construct containing the 179 nt on the 5' side of the CYP2B1/B2 gene linked to the I exon in a cell-free system from liver nuclei. The purified protein can give rise to all the three complexes (I, II, and III) with the PE, just as the crude nuclear extract, under appropriate conditions. Manipulations in vitro indicate that the NE has a significantly higher affinity for the dephosphorylated form than for the phosphorylated form of the protein. The PE binds both forms. Phenobarbitone treatment of the animal leads to a significant increase in the phosphorylation of the 26- to 28-kDa and 94-kDa proteins in nuclear labeling experiments followed by isolation on a PE affinity column. We propose that the protein binding predominantly to the NE in the dephosphorylated state characterizes the basal level of transcription of the CYP2B1/B2 gene. Phenobarbitone treatment leads to phosphorylation of the protein, shifting the equilibrium toward binding to the PE. This can promote interaction with an upstream

  20. pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.

    PubMed

    Varma, Manthena V; Rotter, Charles J; Chupka, Jonathan; Whalen, Kevin M; Duignan, David B; Feng, Bo; Litchfield, John; Goosen, Theunis C; El-Kattan, Ayman F

    2011-08-01

    The human organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) is ubiquitously expressed and may play an important role in the disposition of xenobiotics. The present study aimed to examine the role of OATP2B1 in the intestinal absorption and tissue uptake of 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) reductase inhibitors (statins). We first investigated the functional affinity of statins to the transporter as a function of extracellular pH, using OATP2B1-transfeced HEK293 cells. The results indicate that OATP2B1-mediated transport is significant for rosuvastatin, fluvastatin and atorvastatin, at neutral pH. However, OATP2B1 showed broader substrate specificity as well as enhanced transporter activity at acidic pH. Furthermore, uptake at acidic pH was diminished in the presence of proton ionophore, suggesting proton gradient as the driving force for OATP2B1 activity. Notably, passive transport rates are predominant or comparable to active transport rates for statins, except for rosuvastatin and fluvastatin. Second, we studied the effect of OATP modulators on statin uptake. At pH 6.0, OATP2B1-mediated transport of atorvastatin and cerivastatin was not inhibitable, while rosuvastatin transport was inhibited by E-3-S, rifamycin SV and cyclosporine with IC(50) values of 19.7 ± 3.3 μM, 0.53 ± 0.2 μM and 2.2 ± 0.4 μM, respectively. Rifamycin SV inhibited OATP2B1-mediated transport of E-3-S and rosuvastatin with similar IC(50) values at pH 6.0 and 7.4, suggesting that the inhibitor affinity is not pH-dependent. Finally, we noted that OATP2B1-mediated transport of E-3-S, but not rosuvastatin, is pH sensitive in intestinal epithelial (Caco-2) cells. However, uptake of E-3-S and rosuvastatin by Caco-2 cells was diminished in the presence of proton ionophore. The present results indicate that OATP2B1 may be involved in the tissue uptake of rosuvastatin and fluvastatin, while OATP2B1 may play a significant role in the intestinal absorption of several

  1. Nonadiabatic couplings in the collisional removal of O(2)(b (1)Sigma(g) (+),v) by O(2).

    PubMed

    Dayou, F; Hernández, M I; Campos-Martínez, J; Hernández-Lamoneda, R

    2010-01-28

    The effect of nonadiabatic couplings on the collisional removal of O(2)(b (1)Sigma(g) (+),v) by O(2)(X (3)Sigma(g) (-), v=0) is investigated. Two-dimensional adiabatic and quasidiabatic potential energy surfaces for the excited dimer states and the corresponding nonadiabatic radial couplings have been computed by means of ab initio calculations. Alternately, a two-state theoretical model, based on the Landau-Zener and Rosen-Zener-Demkov assumptions, has been employed to derive analytical forms for the nonadiabatic couplings and an adiabatic-to-diabatic transformation only depending on a reduced set of adiabatic energy terms. Compared to the ab initio results, the predictions of the model are found to be highly accurate. Quantum dynamics calculations for the removal of the first ten vibrational states of O(2)(b (1)Sigma(g) (+),v) indicate a clear dominant contribution of the vibration-electronic relaxation mechanism relative to the vibration-translation energy transfer. Although the present reduced-dimensionality model precludes any quantitative comparison with experiments, it is found that the removal probabilities for v=1-3 are qualitatively consistent with the experimental observations, once the vibrational structure of the fragments is corrected with spectroscopical terms. Besides, the model served to show how the computation of the adiabatic PESs just at the crossing seam was sufficient to describe the nonadiabatic dynamics related to a given geometrical arrangement. This implies considerable savings in the calculations which will eventually allow for larger accuracy in the ab initio calculations as well as higher dimensional treatments. PMID:20113039

  2. Applications of stable V79-derived cell lines expressing rat cytochromes P4501A1, 1A2, and 2B1.

    PubMed

    Doehmer, J; Wölfel, C; Dogra, S; Doehmer, C; Seidel, A; Platt, K L; Oesch, F; Glatt, H R

    1992-01-01

    1. Chinese hamster V79-derived cell lines, stably expressing cytochromes P4501A1, 1A2, and 2B1 activities, were constructed by genetic engineering in continuation of our work to establish a battery of V79 derived cell lines designed to study the metabolism of xenobiotics. 2. Cell lines XEM1 and XEM2, expressing cytochrome P4501A1, were capable of the O-dealkylation of 7-ethoxycoumarin and the hydroxylation of benzo[a]pyrene. 3. Cell lines XEMd.MZ and XEMd.NH, expressing P4501A2, were shown to hydroxylate 17 beta-estradiol and 2-aminofluorene. 4. Cell line SD1, expressing cytochrome P4502B1, was able to hydroxylate testosterone stereo- and regio-specifically at the 16 alpha and 16 beta positions. 5. Cell lines were validated in mutagenicity, cytotoxicity, and metabolism studies employing benzo[a]pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene, cyclophosphamide, ifosfamide, and picene. 6. Construction of metabolically-competent V79-derived cell lines be recombinant DNA technology will be a fundamental improvement for the evaluation of the cytotoxic, genotoxic and pharmacological properties of a chemical. PMID:1441600

  3. The convertible engine: A dual-mode propulsion system

    NASA Technical Reports Server (NTRS)

    Mcardle, Jack G.

    1988-01-01

    A variable inlet guide vane (VIGV) convertible engine that could be used to power future high-speed rotorcraft was tested on an outdoor stand. The engine ran stably and smoothly in the turbofan, turboshaft, and dual (combined fan and shaft) power modes. In the turbofan mode with the VIGV open, fuel consumption was comparable to that of a conventional turbofan engine. In the turboshaft mode with the VIGV closed, fuel consumption was higher than that of present turboshaft engines because power was wasted in churning fan-tip air flow. In dynamic performance tests with a specially built digital engine control and using a waterbrake dynamometer for shaft load, the engine responded effectively to large steps in thrust command and shaft torque. Previous mission analyses of a conceptual X-wing rotorcraft capable of 400-knot cruise speed were revised to account for more fan-tip churning power loss that was originally estimated. The calculations confirm that using convertible engines rather than separate life and cruise engines would result in a smaller, lighter craft with lower fuel use and direct operating cost.

  4. Cu-catalyzed direct C-H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles.

    PubMed

    Xie, Zengyang; Zhu, Xiaojun; Guan, Yangfan; Zhu, Dunru; Hu, Hongwen; Lin, Chen; Pan, Yi; Jiang, Juli; Wang, Leyong

    2013-02-28

    An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4-triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed. PMID:23328869

  5. Detection of vibrational bending mode ν8 and overtone bands of the propargyl radical, HCCCH2 X̃ 2B1.

    PubMed

    Zhang, Xu; Sander, Stanley P; Chaimowitz, Adam; Ellison, G Barney; Stanton, John F

    2010-11-18

    Infrared (IR) absorption spectra of matrix-isolated HCCCH(2) have been measured. Propargyl radicals were generated in a supersonic pyrolysis nozzle, using a method similar to that described in a previous study (Jochnowitz, E. B.; Zhang, X.; Nimlos, M. R.; Varner, M. E.; Stanton, J. F.; Ellison, G. B. J. Phys. Chem. A 2005, 109, 3812-3821). Besides the nine vibrational modes observed in the previous study, this investigation detected the HCCCH(2) X̃ (2)B(1) out-of-plane bending mode (ν(8)) at 378.0 (±1.9) cm(-1) in a cryogenic argon matrix. This is the first experimental observation of ν(8) for the propargyl radical. In addition, seven overtone and combination bands have also been detected and assigned. Ab initio coupled-cluster anharmonic force field calculations were used to guide the analysis. Furthermore, ν(12), the HCCCH(2) in-plane bending mode, has been assigned to 333 (±10) cm(-1) based on the detection of its overtone (2ν(12), 667.7 ± 1.0 cm(-1)) and a possible combination band (ν(10) + ν(12), 1339.0 ± 0.8 cm(-1)). This is the first experimental estimation of ν(12) for the propargyl radical. PMID:20973539

  6. Experimental study of ceramic coated tip seals for turbojet engines

    NASA Technical Reports Server (NTRS)

    Biesiadny, T. J.; Klann, G. A.; Lassow, E. S.; Mchenry, M.; Mcdonald, G.; Hendricks, R. C.

    1985-01-01

    Ceramic gas-path seals were fabricated and successfully operated over 1000 cycles from flight idle to maximum power in a small turboshaft engine. The seals were fabricated by plasma spraying zirconia over a NiCoCrAlX bond boat on the Haynes 25 substrate. Coolant-side substrate temperatures and related engine parameters were recorded. Post-test inspection revealed mudflat surface cracking with penetration to the ceramic bond-coat interface.

  7. Nucleotide sequences of an important functional gene hnRNPA2/B1 from Ailuropoda melanoleuca and Ursus thibetanus mupinensis and its potential value in phylogenetic study.

    PubMed

    Du, Yu-jie; Hou, Yi-ling; Hou, Wan-ru

    2014-01-01

    The cDNA fragments of hnRNPA2/B1 were cloned from the giant panda and black bear using RT-PCR method, which were, respectively, 1029bp and 1026bp in length encoding 343 and 341 amino acids. Analysis indicated the cDNA cloned from the giant panda encoded variant B1 while the cDNA cloned from black bear encoded variant A2. Analyzing the hnRNPA2B1 peptide of the giant panda and black bear, 76 glycine residues and 86 glycine residues were, respectively, found, and moreover, most glycine are concentrated in the latter halves of the hnRNPA2B1 peptides. Functional sites prediction also showed many N-myristoylation sites existed in the glycine-rich domain, which is probably related to the role of telomere maintenance. From base bias and substitution analysis, we can conclude that the ORF of hnRNPA2/B1 biased G while hated C, and transition of the third site did not achieve the level of saturation. Orthology analysis indicated that both the nucleotide sequence and the deduced amino acid sequence showed high identity to other 26 hnRNPA2/B1 sequences from mammals and nonmammals reported. These sequences were used to construct phylogenetic trees employing the NJ method with 1000 bootstrap, and the obtained tree demonstrated similar topology with the classical systematics, which suggested the potential value of hnRNPA2/B1 in phylogenetic analysis. This report will be the first step to the study function of hnRNPA2/B1 in the giant panda and black bear, and will provide a scientific basis to disease surveillance, captive breeding, and conservation of the endangered species. PMID:24588753

  8. Orange and apple juice greatly reduce the plasma concentrations of the OATP2B1 substrate aliskiren

    PubMed Central

    Tapaninen, Tuija; Neuvonen, Pertti J; Niemi, Mikko

    2011-01-01

    AIM The aim of this study was to investigate the effects of orange juice and apple juice on the pharmacokinetics and pharmacodynamics of aliskiren. METHODS In a randomized crossover study, 12 healthy volunteers ingested 200 ml of orange juice, apple juice or water three times daily for 5 days. On day 3, they ingested a single 150-mg dose of aliskiren. Plasma aliskiren concentrations were measured up to 72 h, its excretion into urine up to 12 h and plasma renin activity up to 24 h. RESULTS Orange and apple juice reduced aliskiren peak plasma concentrations by 80% (95% CI 63%, 89%, P < 0.001) and 84% (95% CI 72%, 91%, P < 0.001), and the area under the plasma aliskiren concentration–time curve (AUC) by 62% (95% CI 47%, 72%, P < 0.001) and 63% (95% CI 46%, 74%, P < 0.001), respectively, but had no significant effect on its elimination half-life or renal clearance. The decreases in aliskiren AUC by orange and apple juice correlated with aliskiren AUC during the water phase (r = 0.98, P < 0.001). Plasma renin activity was 87% and 67% higher at 24 h after aliskiren during the orange juice and apple juice phases, respectively, than during the water phase (P < 0.05). CONCLUSIONS Orange juice and apple juice greatly reduce the plasma concentrations and renin-inhibiting effect of aliskiren, probably by inhibiting its OATP2B1-mediated influx in the small intestine. Concomitant intake of aliskiren with orange or apple juice is best avoided. PMID:21204914

  9. Microwave Spectrum of the AsD2(&Xtilde;2B1) Radical: Harmonic Force Field and Molecular Structure.

    PubMed

    Fujiwara; Saito

    1998-12-01

    The pure rotational spectrum of AsD2 in the 2B1 ground electronic state was measured in the frequency region of 268-398 GHz by microwave spectroscopy. The AsD2 radical was generated in a free-space cell by dc-glow discharge of a gaseous mixture of D2 and He over arsenic powder. Fifty fine and hyperfine components of nine rotational transitions were measured and analyzed by least-squares methods determining the detailed molecular constants of AsD2: the rotational constants, the centrifugal distortion constants, the spin-rotation coupling constant with the centrifugal distortion terms, and the hyperfine coupling constants associated with the arsenic and deuterium nuclei. The harmonic force field of AsH2 was determined from the centrifugal distortion constants, the equilibrium vibrational frequency of nu2 mode of AsH2, and the inertial defects of AsH2 and AsD2. The harmonic force field was used to calculate vibrational corrections to the rotational constants of both species and thus the zero-point average structures for both species were derived; AsH2: rz(AsH) = 1.53436(15) Å, thetaz(HAsH) = 90.695(20) degrees, and AsD2: rz(AsD) = 1.52902(13) Å, thetaz(DAsD) = 90.722(17) degrees, where the errors in parentheses are due to residual inertial defects of the corrected moments of inertia. From the difference between the rz structures for AsH2 and AsD2 the re structure of AsH2 is estimated to be re(AsH) = 1.5158(6) Å, thetae(HAsH) = 90.79(8) degrees. Copyright 1998 Academic Press. PMID:9831507

  10. NASA Glenn's Engine Components Research Lab, Cell 2B, Reactivated to Support the U.S. Army Research Laboratory T700 Engine Test

    NASA Technical Reports Server (NTRS)

    Beltran, Luis R.; Griffin, Thomas A.

    2004-01-01

    The U.S. Army Vehicle Technology Directorate at the NASA Glenn Research Center has been directed by their parent command, the U.S. Army Research Laboratory (ARL), to demonstrate active stall technology in a turboshaft engine as the next step in transitioning this technology to the Army and aerospace industry. Therefore, the Vehicle Technology Directorate requested the reactivation of Glenn's Engine Components Research Lab, Cell 2B, (ECRL 2B). They wanted to test a T700 engine that had been used previously for turboshaft engine research as a partnership between the Army and NASA on small turbine engine research. ECRL 2B had been placed in standby mode in 1997. Glenn's Testing Division initiated reactivation in May 2002 to support the new research effort, and they completed reactivation and improvements in September 2003.

  11. PYRROLO[1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) induce apoptosis in K562 cells

    PubMed Central

    Marfe, Gabriella; Di Stefano, Carla; Silvestri, Romano; Abruzzese, Elisabetta; Catalano, Gianfranco; Di Renzo, Livia; Filomeni, Giuseppe; Giorda, Ezio; La Regina, Giuseppe; Morgante, Emanuela; Ciriolo, Maria Rosa; Russo, Matteo Antonio; Amadori, Sergio; Sinibaldi-Salimei, Paola

    2007-01-01

    Background The objective of this study was to gain insight into the molecular mechanism of induced cell death (apoptosis) by PYRROLO [1,2-b][1,2,5]BENZOTHIADIAZEPINES (PBTDs) series compounds, using human (K562) cells as a model. Methods We focused our attention on some members of the PBTDs family to test their potential apoptotic activity in K562 cells. Important apoptotic activity was demonstrated, as evidenced by the concentration and percentage of cell death quantified by measuring PI-uptake by flow cytometry, and DNA fragmentation analyzed by agarose gel electrophoresis, generating a characteristic ladder pattern of discontinuous DNA fragments. The expression of Bcl-2 family was tested using western blotting and transfection method. Results PBTDs-mediated suppression of K562 cell proliferation was induced by apoptosis characterized by the appearance of DNA fragmentation and was associated with the poly(ADP-ribose)polymerase (PARP) cleavage. PBTD-1 and -3 treatment resulted in caspase-3 activation through down-regulation of Bcl-2 and up-regulation of Bax. Furthermore, we used K562/vector and K562/bcl-2 cells, which were generated by transfection of the cDNA of the Bcl-2 gene. As compared with K562/vector, K562/Bcl-2 cells exhibited a 4-fold greater expression of Bcl-2. Treatment with 10 μM PBTD-1 and -3 for 24 h produced morphological features of apoptosis and DNA fragmentation in K562/vector cells, respectively. In contrast, PBTD-1 and -3-induced caspase-3 activation and apoptosis were inhibited in K562/Bcl-2. Furthermore, Bcl-2 overexpressing cells exhibited less cytocrome c release during PBTDs-induced apoptosis. Conclusion These results indicate that PBTDs effectively induce apoptosis of K562 leukemia cells through the activation of caspase cascades. In addition, these findings indicate that Bcl-2 inhibits PBTD-1 and -3 induced-apoptosis via a mechanism that interferes with cytocrome c release, and the activity of caspase-3, which is involved in the

  12. Organic Anion Transporting Polypeptide (OATP)2B1 Contributes to Gastrointestinal Toxicity of Anticancer Drug SN-38, Active Metabolite of Irinotecan Hydrochloride.

    PubMed

    Fujita, Daichi; Saito, Yoshimasa; Nakanishi, Takeo; Tamai, Ikumi

    2016-01-01

    Gastrointestinal toxicity, such as late-onset diarrhea, is a significant concern in irinotecan hydrochloride (CPT-11)-containing regimens. Prophylaxis of late-onset diarrhea has been reported with use of Japanese traditional (Kampo) medicine containing baicalin and with the antibiotic cefixime, and this has been explained in terms of inhibition of bacterial deconjugation of SN-38-glucuronide since unconjugated SN-38 (active metabolite of CPT-11) is responsible for the gastrointestinal toxicity. It is also prerequisite for SN-38 to be accumulated in intestinal tissues to exert toxicity. Based on the fact that liver-specific organic anion transporting polypeptide (OATP)1B1, a member of the same family as OATP2B1, is known to be involved in hepatic transport of SN-38, we hypothesized that intestinal transporter OATP2B1 contributes to the accumulation of SN-38 in gastrointestinal tissues, and its inhibition would help prevent associated toxicity. We found that uptake of SN-38 by OATP2B1-expressing Xenopus oocytes was significantly higher than that by control oocytes. OATP2B1-mediated uptake of SN-38 was saturable, pH dependent, and decreased in the presence of baicalin, cefixime, or fruit juices such as apple juice. In vivo gastrointestinal toxicity of SN-38 in mice caused by oral administration for consecutive 5 days was prevented by coingestion of apple juice. Thus, OATP2B1 contributes to the uptake of SN-38 by intestinal tissues, triggering gastrointestinal toxicity. So, in addition to the reported inhibition of bacterial β-glucuronidase by cefixime or baicalin, inhibition of OATP2B1 may also contribute to prevention of gastrointestinal toxicity. Apple juice may be helpful for prophylaxis of late-onset diarrhea observed in CPT-11 therapy without disturbance of the intestinal microflora. PMID:26526067

  13. Oxysterol Sulfation by SULT2B1b Suppresses LXR/SREBP-1c Signaling Pathway and Reduces Serum and Hepatic Lipids in Mouse Models of NAFLD

    PubMed Central

    Bai, Qianming; Zhang, Xin; Xu, Leyuan; Kakiyama, Genta; Heuman, Douglas; Sanyal, Arun; Pandak, William M.; Yin, Lianhua; Xie, Wen; Ren, Shunlin

    2012-01-01

    Background Cytosolic sulfotransferase (SULT2B1b) catalyzes oxysterol sulfation. 5-cholesten-3β-25-diol-3-sulfate (25HC3S), one product of this reaction, decreases intracellular lipids in vitro by suppressing LXR/SREBP-1c signaling, with regulatory properties opposite to those of its precursor 25-hydroxycholesterol (25HC). Up-regulation of SULT2B1b may be an effective strategy to treat hyperlipidemia and hepatic steatosis. Objectives To explore the effect and mechanism of oxysterol sulfation by SULT2B1b on lipid metabolism in vivo. Methods C57BL/6 and LDLR−/− mice were fed with high-cholesterol diet (HCD) or high-fat diet (HFD) for 10 weeks, and infected with adenovirus encoding SULT2B1b. SULT2B1b expressions in different tissues were determined by immunohistochemistry and western blot. Sulfated oxysterols in liver were analyzed by HPLC. Serum and hepatic lipid levels were determined by Wako Reagents and hematoxylin and eosin (H&E) staining. Gene expressions were determined by real-time RT-PCR and Western Blot. Results Following infection, SULT2B1b was successfully overexpressed in liver, aorta and lung tissues, but not in heart or kidney. SULT2B1b overexpression, combined with administration of 25HC, significantly increased the formation of 25HC3S in liver tissue; significantly decreased serum and hepatic lipid levels, including triglycerides, total cholesterol, free cholesterol, and free fatty acids, as compared to controls both in C57BL/6 and LDLR−/− mice. Gene expression analysis showed that increases in SULT2B1b expression were accompanied by reduction in key regulators and enzymes involved in lipid metabolism, including LXRα, SREBP-1, SREBP-2, acetyl-CoA carboxylase-1 (ACC1) and fatty acid synthase (FAS). Conclusion These findings support the hypothesis that 25HC3S is an important endogenous regulator of lipid biosynthesis. This pathway may represent a novel target for pharmacological intervention in NAFLD. PMID:22225954

  14. Research requirements for development of regenerative engines for helicopters

    NASA Technical Reports Server (NTRS)

    Semple, R. D.

    1976-01-01

    The improved specific fuel consumption of the regenerative engine was compared to a simple-cycle turboshaft engine. The performance improvement and fuel saving are obtained at the expense of increased engine weight, development and production costs, and maintenance costs. Costs and schedules are estimated for the elements of the research and development program. Interaction of the regenerative engine with other technology goals for an advanced civil helicopter is examined, including its impact on engine noise, hover and cruise performance, helicopter empty weight, drive-system efficiency and weight, one-engine-inoperative hover capability, and maintenance and reliability.

  15. Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells

    PubMed Central

    Brännström, Marie; Nordell, Pär; Bonn, Britta; Davis, Andrew M.; Palmgren, Anna-Pia; Hilgendorf, Constanze; Rubin, Katarina; Grime, Ken

    2015-01-01

    Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. This claim has been challenged with conflicting data and here we used OATP2B1-transfected HEK293 cells to clarify the mechanisms involved. For montelukast, no significant difference in cell uptake between HEK-OATP2B1 and empty vector cell lines was observed at pH 6.5 or pH 7.4, and no concentration-dependent uptake was detected. Montelukast is a carboxylic acid, a relatively potent inhibitor of OATP1B1, OATP1B3, and OATP2B1, and has previously been postulated to be actively transported into human hepatocytes. Using OATP1B1-transfected HEK293 cells and primary human hepatocytes in the presence of OATP inhibitors we demonstrate for the first time that active OATP-dependent transport is unlikely to play a significant role in the human disposition of montelukast. PMID:26694455

  16. FASTING FOR LESS THAN 24 H INDUCES CYTOCHROME P450 2E1 AND 2B1/2ACTIVITIES IN RATS

    EPA Science Inventory

    Cytochrome p450 (CYP) 2E1 activity is induced after 24hr of fasting but no information is available for shorter fasting periods. e investigated the induction of CYP 2E1 in rats during the first 24 hours of food deprivation by examining marker activities for CYP isozymes 2b 1/2 an...

  17. Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells.

    PubMed

    Brännström, Marie; Nordell, Pär; Bonn, Britta; Davis, Andrew M; Palmgren, Anna-Pia; Hilgendorf, Constanze; Rubin, Katarina; Grime, Ken

    2015-01-01

    Clinical studies with montelukast show variability in effect and polymorphic OATP2B1-dependent absorption has previously been implicated as a possible cause. This claim has been challenged with conflicting data and here we used OATP2B1-transfected HEK293 cells to clarify the mechanisms involved. For montelukast, no significant difference in cell uptake between HEK-OATP2B1 and empty vector cell lines was observed at pH 6.5 or pH 7.4, and no concentration-dependent uptake was detected. Montelukast is a carboxylic acid, a relatively potent inhibitor of OATP1B1, OATP1B3, and OATP2B1, and has previously been postulated to be actively transported into human hepatocytes. Using OATP1B1-transfected HEK293 cells and primary human hepatocytes in the presence of OATP inhibitors we demonstrate for the first time that active OATP-dependent transport is unlikely to play a significant role in the human disposition of montelukast. PMID:26694455

  18. Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital.

    PubMed

    He, K; Falick, A M; Chen, B; Nilsson, F; Correia, M A

    1996-01-01

    The olefinic barbiturate secobarbital (SB) is a sedative hypnotic known to be a relatively selective mechanism-based inactivator of rat liver cytochrome P450 2B1. Previous studies have demonstrated that such inactivation results in prosthetic heme destruction and irreversible drug-induced protein modification, events most likely triggered by P450 2B1-dependent oxidative activation of the olefinic pi-bond. However, the precise structure of the SB-modified heme and/or the protein site targeted for attack remained to be elucidated. We have now isolated the SB-heme adduct from P450 2B1 inactivated by [14C]SB in a functionally reconstituted system and structurally characterized it by electronic absorption spectroscopy and tandem collision-induced dissociation (CID), matrix-assisted laser desorption ionization on time of flight (MALDI-TOF), and liquid secondary ion mass spectrometry in the positive mode (+ LSIMS) as the N-(5-(2-hydroxypropyl)-5-(1-methylbutyl)barbituric acid)protoporphyrin IX adduct. The [14C]SB-modified 2B1 protein has also been isolated from similar inactivation systems and subjected to lysyl endopeptidase C (Lys-C) digestion and HPLC-peptide mapping. A [14C]SB-modified 2B1 peptide was thus isolated, purified, electrotransferred onto a poly-(vinylidene) membrane, and identified by micro Edman degradation of its first N-terminal 17 residues (S277NH(H)TEFH(H)ENLMISLL293) as the Lys-C peptide domain comprised of amino acids 277-323. This peptide thus includes the peptide domain corresponding to the distal helix I of P450 101, a region highly conserved through evolution, and which is known not only to flank the heme moiety but also to intimately contact the substrates. This finding thus suggests that SB-induced protein modification of P450 2B1 also occurs at the active site and, together with heme N-alkylation, contributes to the SB-induced mechanism-based inactivation of P450 2B1. PMID:8728507

  19. Relative Yield of O2(b1σ+_g, v = 0 and 1) in O(1D) + O2 Collisions

    NASA Astrophysics Data System (ADS)

    Kalogerakis, K. S.; Pejaković, D. A.; Copeland, R. A.; Slanger, T. G.

    2005-12-01

    In the thermosphere, energy transfer from excited O-atoms leads to production of O2 molecules in the first two vibrational levels of the O2(b1σ+_g) state: O(1D) + O2 → O(3P) + O2(b1σ+_g, v = 0, 1). Subsequent radiative decay of O2(b1σ+_g, v = 0 and 1) to the ground state, O2(X3σ-_g), results in the Atmospheric Band emission. The relative yield for production of O2(b1σ+_g, v = 0 and 1) in the above process, k1/k0, is an important parameter in modeling of the observed Atmospheric Band emission intensities. We report laboratory measurements of k1/k0, in which the output of a pulsed fluorine laser at 157 nm is used to photodissociate molecular oxygen in a O2/N2 mixture. Photodissociation of O2 produces a ground-state O(3P) atom and an excited O(1D) atom. O(1D) rapidly transfers energy to the remaining O2 to produce O2(b1σ+_g, v = 0, 1). The temporal evolution of the O2(b1σ+_g, v = 0 and 1) populations is monitored by observing emissions in the O2(b--X) 0-0 and 1-1 bands at 762 and 771 nm, respectively. The value of k1/k0 is extracted from the time-dependent O2(b1σ+_g, v = 0 and 1) fluorescence signals, based on a detailed understanding of the kinetics involved. Two published studies reported that energy transfer to O2(b1σ+_g, v = 0) is favored, with a k1/k0 ratio in the range 0.3--1 [1, 2]. In contrast, our more direct measurements clearly indicate that production of O2(b1σ+_g, v = 1) dominates that of O2(b1σ+_g, v = 0), with a value of k1/k0 in the range 3--4. Comparisons with high-altitude spectra of the O2(b--X) 0-0 and 1-1 bands obtained during the Arizona Airglow Experiment (GLO) support our experimental finding and suggest that a major revision of the input for k1/k0 in atmospheric models is warranted. This work was supported by the NSF Aeronomy Program under grant ATM-0209229. The fluorine laser was purchased under grant ATM-0216583 from the NSF Major Research Instrumentation Program. 1. M. J. E. Gauthier and D. R. Snelling, Can. J. Chem. 52, 4007

  20. Effect of sulfur dioxide inhalation on CYP2B1/2 and CYP2E1 in rat liver and lung

    SciTech Connect

    Guohua Qin; Ziqiang Meng

    2006-07-15

    Sulfur dioxide (SO{sub 2}) is a ubiquitous air pollutant, present in low concentrations in the urban air and in higher concentrations in the working environment. In this study, we investigated the effects of inhaled SO{sub 2} on the O-dealkylase of pentoxyresorufin (PROD) and p-nitrophenol hydroxylases (p-NP) activities and mRNA levels of CYP2B1/2 and CYP2E1 in the lung and liver of Wistar rats. Male Wistar rats were housed in exposure chambers and treated with 14.11 {+-}1.53, 28.36 {+-} 2.12, and 56.25 {+-} 4.28 mg /m{sup 3}SO{sub 2} for 6 h/day for 7 days, while control rats were exposed to filtered air in the same condition. The mRNAs of CYP2B1/2 and -2E1 were analyzed in livers and lungs by using reverse-transcription polymerase chain reaction (RT-PCR). Results showed that the PROD activities and mRNA of CYP2B1/2 were decreased in livers and lungs of rats exposed to SO{sub 2}. The p-NP activities and mRNA of CYP2E1 were decreased in lungs but not in livers of rats exposed to SO{sub 2}. Total liver microsomal cytochrome P-450 (CYP) contents were diminished in SO{sub 2} -exposed rats. These results lead to two conclusions: (1) SO{sub 2} exposure can suppress CYP2B1/2 and CYP2E1 in lungs and CYP2B1/2 in livers of rats, thus modifying the liver and lung toxication/detoxication potential, and (2) the total liver microsomal CYP contents were diminished, although the activity and mRNA expression of CYP2E1 in rat livers were not affected by SO{sub 2} exposure.

  1. An update of engine system research at the Army Propulsion Directorate

    NASA Technical Reports Server (NTRS)

    Bobula, George A.

    1990-01-01

    The Small Turboshaft Engine Research (STER) program provides a vehicle for evaluating the application of emerging technologies to Army turboshaft engine systems and to investigate related phenomena. Capitalizing on the resources at hand, in the form of both the NASA facilities and the Army personnel, the program goal of developing a physical understanding of engine system dynamics and/or system interactions is being realized. STER entries investigate concepts and components developed both in-house and out-of-house. Emphasis is placed upon evaluations which have evolved from on-going basic research and advanced development programs. Army aviation program managers are also encouraged to make use of STER resources, both people and facilities. The STER personnel have established their reputations as experts in the fields of engine system experimental evaluations and engine system related phenomena. The STER facility has demonstrated its utility in both research and development programs. The STER program provides the Army aviation community the opportunity to perform system level investigations, and then to offer the findings to the entire engine community for their consideration in next generation propulsion systems. In this way results of the fundamental research being conducted to meet small turboshaft engine technology challenges expeditiously find their way into that next generation of propulsion systems.

  2. An update of engine system research at the Army Propulsion Directorate

    NASA Technical Reports Server (NTRS)

    Bobula, George A.

    1990-01-01

    The Small Turboshaft Engine Research (STER) program provides a vehicle for evaluating the application of emerging technologies to Army turboshaft engine systems and to investigate related phenomena. Capitalizing on the resources at hand, in the form of both the NASA facilities and the Army personnel, the program goal of developing a physical understanding of engine system dynamics and/or system interactions is being realized. STER entries investigate concepts and components developed both in-house and out-of-house. Emphasis is placed upon evaluations which evolved from on-going basic research and advanced development programs. Army aviation program managers are also encouraged to make use of STER resources, both people and facilities. The STER personnel have established their reputations as experts in the fields of engine system experimental evaluations and engine system related phenomena. The STER facility has STER program provides the Army aviation community the opportunity to perform system level investigations, and then to offer the findings to the entire engine community for their consideration in next generation propulsion systems. In this way results of the fundamental research being conducted to meet small turboshaft engine technology challenges expeditiously find their way into that next generation of propulsion systems.

  3. Experimental study of ceramic-coated tip seals for turbojet engines

    NASA Technical Reports Server (NTRS)

    Biesiadny, T. J.; Mcdonald, G.; Hendricks, R. C.; Klann, G. A.; Lassow, E. S.

    1985-01-01

    Ceramic gas-path seals were fabricated and successfully operated over 1000 cycles from flight idle to maximum power in a small turboshaft engine. The seals were fabricated by plasma spraying zirconia over a NiCoCrAlX bond coat on the Haynes 25 substrate. Coolant-side substrate temperatures and related engine parameters were recorded. Post-test inspection revealed mudflat surface cracking with penetration to the ceramic bond-coat interface.

  4. 76 FR 54143 - Airworthiness Directives; Turbomeca Arriel 1B Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... Order 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR... Nozzle Guide Vanes (NGVs) to be installed on Pre TU 148 standard Arriel 1B were found not conforming...

  5. 78 FR 15597 - Special Conditions: GE Aviation CT7-2E1 Turboshaft Engine Model

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-12

    ... published on July 20, 2012 (77 FR 42677). We received six comments from European Aviation Safety Agency... the special conditions 33-002-SC, published on May 28, 1999 (64 FR 28900). We are therefore adopting...)(7), and 33.88(c). The 2.5 minute time duration for the rating would affect the structural...

  6. 77 FR 42677 - Special Conditions: General Electric CT7-2E1 Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... Privacy Act Statement can be found in the Federal Register published on April 11, 2000 (65 FR 19477-19478... structural and operational characteristics that are time dependent, such as the values for transients, time duration for stabilization to steady state, and part growth due to deformation. In addition, we...

  7. 78 FR 23830 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-23

    ... specified products. That NPRM was published in the Federal Register on December 11, 2012 (77 FR 73557). That... opportunity to participate in developing this AD. We received no comments on the NPRM (77 FR 73557, December 11, 2012). Actions Since We Issued the Proposed Rule Since we issued the NPRM (77 FR 73557,...

  8. 75 FR 7027 - Airworthiness Directives; Turbomeca Arriel 2S1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-16

    ... NPRM was published in the Federal Register on October 28, 2009 (74 FR 55491). That NPRM proposed to... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant... unsafe condition on an aviation product. The MCAI describes the unsafe condition as: During...

  9. 78 FR 77569 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-24

    ... (78 FR 48824). The NPRM proposed to correct an unsafe condition for the specified products. The MCAI... this AD. We received no comments on the NPRM (78 FR 48824, August 12, 2013). Conclusion We reviewed the... Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska to the...

  10. 78 FR 11563 - Airworthiness Directives; Pratt & Whitney Canada Corp Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-19

    ... Register on October 25, 2012 (77 FR 65142). That NPRM proposed to correct an unsafe condition for the... opportunity to participate in developing this AD. We received no comments on the NPRM (77 FR 65142, October 25... require adopting the AD as proposed (77 FR 65142, October 25, 2012). Costs of Compliance Based on...

  11. 78 FR 14442 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    ... November 9, 2011, we issued AD 2011-24-08, Amendment 39-16872 (76 FR 72091, November 22, 2011), for all... helicopter. Actions Since AD Was Issued Since we issued AD 2011-24-08 (76 FR 72091, November 22, 2011... 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...

  12. 75 FR 30270 - Airworthiness Directives; Turbomeca Astazou XIV B and XIV H Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-01

    ... products. That NPRM was published in the Federal Register on March 30, 2010 (75 FR 15627). That NPRM... ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3... consisted of a turbine blade together with the rim piece immediately below the blade. The rim piece...

  13. 75 FR 2787 - Airworthiness Directives; Turbomeca Turmo IV A and IV C Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78...'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have... J PUMA helicopters. Reason (d) During a maintenance inspection before the first flight of the...

  14. 76 FR 78863 - Airworthiness Directives; Rolls-Royce Corporation Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will... inspection and fluorescent penetrant inspection (FPI) on certain 3rd and 4th stage turbine wheels for cracks in the turbine blades. We are proposing this AD to prevent failure of 3rd or 4th stage turbine...

  15. 77 FR 40479 - Airworthiness Directives; Rolls-Royce Corporation Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... NPRM published in the Federal Register on December 20, 2011 (76 FR 78863). That NPRM proposed to... Executive Order 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR... a one-time visual inspection and fluorescent penetrant inspection (FPI) on certain 3rd and 4th...

  16. 77 FR 43550 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... 39-13199 (68 FR 36900, June 20, 2003), for all Turbomeca S.A. Arriel 1A, 1A1, 1A2, 1B, 1C, 1C1, 1C2... Existing AD Was Issued Since we issued AD 2003-12-14, Amendment 39-13199 (68 FR 36900, June 20, 2003), in...'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not...

  17. 77 FR 37283 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-21

    ... February 21, 2012 (77 FR 9874). That NPRM proposed to correct an unsafe condition for the specified... public the opportunity to participate in developing this AD. We received no comments on the NPRM (77 FR... Order 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44...

  18. 76 FR 11172 - Special Conditions: Pratt and Whitney Canada Model PW210S Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-01

    ... Operating (AEO) power rating. This rating is intended to be used for hovering at increased power for search... applicant to support rotorcraft search and rescue missions that require extensive hover operations at high... anticipates that for search and rescue, extended hovering maneuvers may require more than maximum...

  19. 76 FR 30819 - Special Conditions: Turbomeca Arriel 2D Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... published on April 1, 2011 (76 FR 18130). One comment letter was received. The commenter agreed with the... power for search and rescue missions. The applicable airworthiness regulations do not contain adequate... rating. This rating was requested by the applicant to support rotorcraft search and rescue missions...

  20. 76 FR 18130 - Special Conditions: Turbomeca Arriel 2D Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-01

    ... generally intended to be used for hovering at increased power for search and rescue missions. The applicable... a 30-minute power rating. This rating was requested by the applicant to support rotorcraft search... that for search and rescue, extended hovering maneuvers may require more than maximum continuous...

  1. 76 FR 40594 - Special Conditions: Pratt and Whitney Canada Model PW210S Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-11

    ... published on March 1, 2011 (76 FR 11172). One comment letter was received. The commenter stated disagreement...) power rating. This rating is generally intended to be used for hovering at increased power for search... requested by the applicant to support rotorcraft search and rescue missions that require...

  2. 77 FR 2930 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-20

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant economic impact, positive...

  3. 77 FR 56585 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-13

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... 12866; 2. Is not a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034... AD docket on the Internet at http://www.regulations.gov ; or in person at the Docket...

  4. 78 FR 47581 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-06

    ... Register published on April 11, 2000 (65 FR 19477-78). Discussion The European Aviation Safety Agency (EASA... Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska... on the 2nd-stage turbine disc. This proposed AD would require replacement of the 2nd-stage...

  5. 75 FR 15627 - Airworthiness Directives; Turbomeca Astazou XIV B and XIV H Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-30

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will... uncommanded in-flight shutdown (IFSD) revealed that a third stage turbine wheel rupture was not contained...

  6. 76 FR 20231 - Airworthiness Directives; Honeywell International Inc. LTS101 Series Turboshaft Engines and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... SNPRM published in the Federal Register on December 17, 2010 (75 FR 78937). The original notice of proposed rulemaking (74 FR 67829, December 21, 2009) proposed to require removing power turbine blades... not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR 11034, February...

  7. 75 FR 78937 - Airworthiness Directives; Honeywell International LTS101 Series Turboshaft Engines and LTP101...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... in the Federal Register published on April 11, 2000 (65 FR 19477-78). Examining the AD Docket You may... the Federal Register on December 21, 2009 (74 FR 67829). That action proposed to require removing... Procedures (44 FR 11034, February 26, 1979); and 3. Would not have a significant economic impact, positive...

  8. 76 FR 42610 - Airworthiness Directives; Turbomeca Arriel 1 Series Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... proposed AD. Discussion On September 10, 2010, we issued AD 2010-19-06, Amendment 39-16434 (75 FR 57371... and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in Alaska...) 2010-19-06, Amendment 39-16434 (75 FR 57371 September 21, 2010), and adding the following new...

  9. 76 FR 77378 - Airworthiness Directives; Turbomeca Arriel 1 Series Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-13

    ... proposed rulemaking (NPRM) to amend 14 CFR part 39 to revise AD 2010-19-06, amendment 39-16434 (75 FR 57371... on July 19, 2011 (76 FR 42610). That NPRM proposed to require removing GG second stage turbine discs... opportunity to participate in developing this AD. We received no comments on the NPRM (76 FR 42610, July...

  10. 78 FR 68697 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-15

    ..., Amendment 39-17321 (78 FR 6725, January 31, 2013), and adding the following new AD: 2013-22-22 Turbomeca S.A...-17321 (78 FR 6725, January 31, 2013). (c) Applicability This AD applies to all Turbomeca S.A. Arriel 2D...-07, Amendment 39-17321 (78 FR 6725, January 31, 2013), (``AD 2013-01-07''). AD 2013-01-07 applied...

  11. 77 FR 71483 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ..., Amendment 39-13199 (68 FR 36900, June 20, 2003). That AD applies to the specified products. The NPRM published in the Federal Register on July 25, 2012 (77 FR 43550). That NPRM proposed to require determining... Policies and Procedures (44 FR 11034, February 26, 1979), (3) Will not affect intrastate aviation in...

  12. 77 FR 66936 - Special Conditions: Turbomeca Ardiden 3K Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-08

    ... the Federal Register published on April 11, 2000 (65 FR 19477-19478), as well as at http://DocketsInfo... (ICA), instrumentation, and endurance testing because the applicable airworthiness standards do not contain adequate or appropriate airworthiness standards to address this design feature. The...

  13. 77 FR 43552 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-25

    ... 2009-03-04, Amendment 39-15805 (74 FR 7796, February 20, 2009), for all Turbomeca S.A. Arriel 1E2, 1S.... Proposed AD Requirements This proposed AD would retain all of the requirements of AD 2009- 03-04, (74 FR... a ``significant rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February...

  14. 77 FR 8092 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-14

    ... listed in this AD as of March 11, 2010 (75 FR 5689, February 4, 2010). ADDRESSES: For service information... proposed rulemaking (NPRM) to amend 14 CFR part 39 to supersede AD 2010-03-06, Amendment 39-16189 (75 FR... Register on November 7, 2011 (76 FR 68661). That NPRM proposed to require inspection and...

  15. 77 FR 23380 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-19

    ..., 2009 (74 FR 34221, July 15, 2009). ADDRESSES: For service information identified in this AD, contact... amend 14 CFR part 39 to supersede AD 2009-14-11, Amendment 39-15961 (74 FR 34221, July 15, 2009). That... (76 FR 77446). That NPRM proposed to continue to require inspections of the P3 air pipe (first...

  16. 78 FR 34284 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-07

    ... 2013-01-07, Amendment 39-17321 (78 FR 6725, January 31, 2013), for all Turbomeca S.A. Arriel 2D... helicopter. Actions Since Existing AD Was Issued Since we issued AD 2013-01-07 (78 FR 6725, January 31, 2013... would maintain the existing AD requirements of AD 2013-01-07 (78 FR 6725, January 31, 2013), and...

  17. 77 FR 24585 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-25

    ... the Federal Register on January 20, 2012 (77 FR 2930). That NPRM proposed to require removing the... on the NPRM (77 FR 2930, January 20, 2012). Clarification of Compliance Time Since we issued the... Order 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44 FR...

  18. 77 FR 71491 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-03

    ... rulemaking (NPRM) to amend 14 CFR part 39 to supersede AD 2009-03-04, Amendment 39-15805 (74 FR 7796... on July 25, 2012 (77 FR 43552). That NPRM proposed to require a one-time inspection and torque check... Executive Order 12866, (2) Is not a ``significant rule'' under DOT Regulatory Policies and Procedures (44...

  19. 77 FR 58002 - Airworthiness Directives; Turbomeca S.A. Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-19

    ... as of August 12, 2011 (76 FR 40222, July 8, 2011). ADDRESSES: For service information identified in... rulemaking (NPRM) to amend 14 CFR part 39 to supersede AD 2011-13-05, Amendment 39-16728 (76 FR 40222, July 8... the Federal Register on June 1, 2012 (77 FR 32437). That NPRM proposed to continue to...

  20. Outdoor test stand performance of a convertible engine with variable inlet guide vanes for advanced rotorcraft propulsion

    NASA Technical Reports Server (NTRS)

    Mcardle, Jack G.

    1986-01-01

    A variable inlet guide van (VIGV) type convertible engine that could be used to power future high-speed rotorcraft was tested on an outdoor stand. The engine ran stably and smoothly in the turbofan, turboshaft, and dual (combined fan and shaft) power modes. In the turbofan mode with the VIGV open fuel consumption was comparable to that of a conventional turbofan engine. In the turboshaft mode with the VIGV closed fuel consumption was higher than that of present turboshaft engines because power was wasted in churning fan-tip airflow. In dynamic performance tests with a specially built digital engine control and using a waterbrake dynamometer for shaft load, the engine responded effectively to large steps in thrust command and shaft torque. Previous mission analyses of a conceptual X-wing rotorcraft capable of 400-knot cruise speed were revised to account for more fan-tip churning power loss than was originally estimated. The new calculations confirm that using convertible engines rather than separate lift and cruise engines would result in a smaller, lighter craft with lower fuel use and direct operating cost.

  1. The GATE studies - Assessing the potential of future small general aviation turbine engines

    NASA Technical Reports Server (NTRS)

    Strack, W. C.

    1979-01-01

    Four studies have been completed that explore the opportunities for future General Aviation Turbine Engines (GATE) in the 150-1000 SHP class. These studies forecasted the potential impact of advanced technology turbine engines in the post-1988 market, identified important aircraft and missions, desirable engine sizes, engine performance and cost goals. Parametric evaluations of various engine cycles, configurations, design features, and advanced technology elements defined baseline conceptual engines for each of the important missions identified by the market analysis. Both fixed-wing and helicopter aircraft, and turboshaft, turboprop, and turbofan engines were considered. Key technology areas were recommended for NASA support in order to realize proposed improvements.

  2. hnRNPA2B1 and hnRNPA1 mutations are rare in patients with "multisystem proteinopathy" and frontotemporal lobar degeneration phenotypes.

    PubMed

    Le Ber, Isabelle; Van Bortel, Inge; Nicolas, Gael; Bouya-Ahmed, Kawtar; Camuzat, Agnès; Wallon, David; De Septenville, Anne; Latouche, Morwena; Lattante, Serena; Kabashi, Edor; Jornea, Ludmila; Hannequin, Didier; Brice, Alexis

    2014-04-01

    hnRNPA2B1 and hnRNPA1 mutations have been recently identified by exome sequencing in three families presenting with multisystem proteinopathy (MSP), a rare complex phenotype associating frontotemporal lobar degeneration (FTLD), Paget disease of bone (PDB), inclusion body myopathy (IBM), and amyotrophic lateral sclerosis (ALS). No study has evaluated the exact frequency of these genes in cohorts of MSP or FTD patients so far. We sequenced both genes in 17 patients with MSP phenotypes, and in 60 patients with FTLD and FTLD-ALS to test whether mutations could be implicated in the pathogenesis of these disorders. No disease-causing mutation was identified. We conclude that hnRNPA2B1 and hnRNPA1 mutations are rare in MSP and FTLD spectrum of diseases, although further investigations in larger populations are needed. PMID:24119545

  3. The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells

    PubMed Central

    Prudente, Sabrina; Morini, Eleonora; Larmon, Jay; Andreozzi, Francesco; Pietro, Natalia Di; Nigro, Angela; Gervino, Ernest V; Mannino, Gaia Chiara; Bacci, Simonetta; Hauser, Thomas H; Bellacchio, Emanuele; Formoso, Gloria; Pellegrini, Fabio; Proto, Vittoria; Menzaghi, Claudia; Frittitta, Lucia; Pandolfi, Assunta; Sesti, Giorgio; Doria, Alessandro; Trischitta, Vincenzo

    2013-01-01

    Objective Obesity and cardiovascular disease recognize a common metabolic soil and may therefore share part of their genetic background. Genome-wide association studies have identified variability at the SH2B1 locus as a predictor of obesity. We investigated whether SNP rs4788102, which captures the entire SH2B1 variability, is associated with coronary artery disease (CAD) and/or myocardial infarction (MI) in patients with type 2 diabetes mellitus (T2DM). Design and Setting SNP rs4788102 was typed in 2,015 White subjects with T2DM from three CAD case-control studies [n=740 from the Gargano Hearth Study (GHS, Italy); n=818 from the Joslin Hearth Study (JHS, Boston); n=457 from the University of Catanzaro (CZ, Italy)]. Results SNP rs4788102 (G/A) was not associated with CAD (overall allelic OR=1.06, 95% CI=0.93-1.21; p=0.37). On the contrary, it was associated with MI in GHS (1.42, 1.12-1.81; p=0.004) and in the three samples analyzed together (1.21, 1.04-1.41; p=0.016). Insulin stimulated nitric oxide synthase (NOS) activity in human vein endothelial cells from G/G (n=4, p=0.03) but not the G/A (n=5, p=0.83) genotype. Of the SNPs in perfect LD with rs4788102, one (rs7498665) affects amino acid polarity (Ala484Thr) and falls into a highly conserved protein segment of SH2B1 containing a class II SH3 domain binding site. Conclusions Variability at the SH2B1 obesity locus is associated with MI in diabetic patients and with reduced insulin-stimulated NOS activity in human endothelial cells. Further studies are needed to replicate this association and dissect the biology underlying this finding. PMID:21907990

  4. Synthesis and Anticonvulsant Evaluation of some New 6-(Substituted-phenyl)thiazolo[3,2-b][1,2,4]triazole Derivatives in Mice

    PubMed Central

    Deng, Xian-Qing; Song, Ming-Xia; Gong, Guo-Hua; Wang, Shi-Ben; Quan, Zhe-Shan

    2014-01-01

    Epilepsy is the most frequent nearological affiction and afflicts 1% about of the world’s population. Currently there is an urgent need for the development of novel anticonvulsants with higher levels of potency and lower levels of toxicity. In this paper, a series of new 6-(substituted-phenyl)thiazolo[3,2-b][1,2,4]triazole derivatives were synthesized and tested for their anticonvulsant activities using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (PTZ) screens, which are the most widely employed seizure models for early identification of candidate anticonvulsants. Their neurotoxicity was determined applying the rotarod test. In these compounds, 6-(4-fluorophenyl)thiazolo[3,2-b][1,2,4]triazole (3c) showed selective protection against the MES seizures with an ED50 value of 49.1 mg/Kg and a TD50 value of 94.1 mg/Kg, which provided compound 3c a protective index (PI = TD50/ED50) of 1.9 in the MES test. 6-(4-Propoxyphenyl)thiazolo[3,2-b][1,2,4]triazole (5b) was found to be active in both models, i.e. MES test and PTZ test. In the PTZ screen, compound 5b gave an ED50 of 63.4 mg/Kg and a TD50 of 105.6 mg/Kg, resulting in a PI value of 1.7 which is higher than carbamazepine. PMID:25237341

  5. Importance of engine as a source of helicopter external noise

    NASA Technical Reports Server (NTRS)

    Janakiram, R. D.; Smith, M. J.; Tadghighi, H.

    1989-01-01

    A turboshaft engine's importance as a source of helicopter external noise is presently evaluated experimentally and analytically on the basis of test data from an MD500E helicopter, with and without engine muffler, during level flyovers and climbing flight. A strong engine noise component is noted for helicopter positions nearly overhead and beyond observed position, especially in the 200-1000 Hz range; its strong rearward directivity suggests the noise source to be the broadband exhaust or combustion noise radiated from the exhaust duct. The engine muffler furnished estimated perceived noise level reductions of 2-3 dB for the centerline.

  6. Absorption of Montelukast is Transporter Mediated: a Common Variant of OATP2B1 is Associated with Reduced Plasma Concentrations and Poor Response

    PubMed Central

    Mougey, Edward B.; Feng, Hua; Castro, Mario; Irvin, Charles G.; Lima, John J.

    2009-01-01

    Objectives (i) determine if montelukast undergoes carrier mediated uptake; (ii) classify the carrier protein(s) responsible for uptake; (iii) identify specific transporters that mediate transport of montelukast; (iv) evaluate whether variation in the gene encoding the transport protein(s) influences the pharmacokinetics and pharmacodynamics of montelukast. Methods In vitro permeability studies of montelukast are conducted using Caco-2 cell culture, a standard model of human intestinal drug transport. In vivo plasma concentrations of montelukast in an asthmatic population are determined by HPLC, and genotyping of transport proteins is by LightTyper analysis. Results Permeability of montelukast has an activation energy of 13.7±0.7 kcal/mol, consistent with carrier mediated transport. Permeability is saturable at high concentrations of montelukast and follows Michaelis-Menten kinetics. Permeability is subject to competition by sulfobromophthalein, estrone 3-sulfate, pravastatin, taurocholic acid, and cholic acid (p<0.05, % of control; 72±7 – 86±7) and is inhibited by 5–10% citrus juice (p<0.05, maximal inhibition % of control; 31±2). An MDCKII cell line expressing OATP2B1 (coded for by the SLCO2B1 gene) displays significantly increased permeability of montelukast (p<0.05, % of control; 140±20). A nonsynonymous polymorphism in SLCO2B1, (rs12422149; SLCO2B1{NM_007256.2}:c.935G>A) associates with significantly reduced plasma concentration in subjects measured on the morning after an evening dose (p<0.025, square root mean transformed plasma concentration ± SE; c.[935G>A]+[935G]=3±1, c.[935G]+[935G]=7.0±0.9) and differential response as assessed by change in baseline Asthma Symptom Utility Index scores following one month of therapy (delta mean Asthma Symptom Utility Index; c.[935G>A]+[935G] = 0.02±0.01, p=1.0; c.[935G]+[935G] = 1.0±0.3, p<0.0001). Conclusions Together these observations suggest that the genetics of SLCO2B1 may be an important variable in

  7. DHA down-regulates phenobarbital-induced cytochrome P450 2B1 gene expression in rat primary hepatocytes by attenuating CAR translocation

    SciTech Connect

    Li, C.-C.; Lii, C.-K.; Liu, K.-L.; Yang, J.-J.; Chen, H.-W.

    2007-12-15

    The constitutive androstane receptor (CAR) plays an important role in regulating the expression of detoxifying enzymes, including cytochrome P450 2B (CYP 2B). Phenobarbital (PB) induction of human CYP 2B6 and mouse CYP 2b10 has been shown to be mediated by CAR. Our previous study showed that PB-induced CYP 2B1 expression in rat primary hepatocytes is down-regulated by both n-6 and n-3 polyunsaturated fatty acids (PUFAs), especially docosahexaenoic acid (DHA); however, the mechanism for this down-regulation by DHA was previously unknown. The objective of the present study was to determine whether change in CAR translocation is involved in the down-regulation by n-6 and n-3 PUFAs of PB-induced CYP 2B1 expression in rat primary hepatocytes. We used 100 {mu}M arachidonic acid, linoleic acid, eicosapentaenoic acid, and DHA to test this hypothesis. PB triggered the translocation of CAR from the cytosol into the nucleus in a dose-dependent and time-dependent manner in our hepatocyte system, and the CAR distribution in rat primary hepatocytes was significantly affected by DHA. DHA treatment decreased PB-inducible accumulation of CAR in the nuclear fraction and increased it in the cytosolic fraction in a dose-dependent manner. The down-regulation of CYP 2B1 expression by DHA occurred in a dose-dependent manner, and a similar pattern was found for the nuclear accumulation of CAR. The results of immunoprecipitation showed a CAR/RXR heterodimer bound to nuclear receptor binding site 1 (NR-1) of the PB-responsive enhancer module (PBREM) of the CYP 2B1gene. The EMSA results showed that PB-induced CAR binding to NR-1 was attenuated by DHA. Taken together, these results suggest that attenuation of CAR translocation and decreased subsequent binding to NR-1 are involved in DHA's down-regulation of PB-induced CYP 2B1 expression.

  8. Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

    PubMed

    Noé, Johannes; Portmann, Renée; Brun, Marie-Elise; Funk, Christoph

    2007-08-01

    Hepatic uptake carriers of the organic anion-transporting peptide (OATP) family of solute carriers are more and more recognized as being involved in hepatic elimination of many drugs and potentially associated drug-drug interactions. The gemfibrozil-statin interaction was studied at the level of active hepatic uptake as a model for such drug-drug interactions. Active, temperature-dependent uptake of fluvastatin into primary human hepatocytes was shown. Multiple transporters are involved in this uptake as Chinese hamster ovary or HEK293 cells expressing either OATP1B1 (K(m) = 1.4-3.5 microM), OATP2B1 (K(m) = 0.7-0.8 microM), or OATP1B3 showed significant fluvastatin uptake relative to control cells. For OATP1B1 the inhibition by gemfibrozil was substrate-dependent as the transport of fluvastatin (IC(50) of 63 microM), pravastatin, simvastatin, and taurocholate was inhibited by gemfibrozil, whereas the transport of estrone-3-sulfate and troglitazone sulfate (both used at 3 microM) was not affected. The OATP1B1- but not OATP2B1-mediated transport of estrone-3-sulfate displayed biphasic saturation kinetics, with two distinct affinity components for estrone-3-sulfate (0.23 and 45 microM). Only the high-affinity component was inhibited by gemfibrozil. Recombinant OATP1B1-, OATP2B1-, and OATP1B3-mediated fluvastatin transport was inhibited to 97, 70, and 62% by gemfibrozil (200 microM), respectively, whereas only a small inhibitory effect by gemfibrozil (200 microM) on fluvastatin uptake into primary human hepatocytes was observed (27% inhibition). The results indicate that the in vitro engineered systems can not always predict the behavior in more complex systems such as freshly isolated primary hepatocytes. Therefore, selection of substrate, substrate concentration, and in vitro transport system are critical for the conduct of in vitro interaction studies involving individual liver OATP carriers. PMID:17470528

  9. hnRNP A2/B1 interacts with influenza A viral protein NS1 and inhibits virus replication potentially through suppressing NS1 RNA/protein levels and NS1 mRNA nuclear export

    SciTech Connect

    Wang, Yimeng; Zhou, Jianhong; Du, Yuchun

    2014-01-20

    The NS1 protein of influenza viruses is a major virulence factor and exerts its function through interacting with viral/cellular RNAs and proteins. In this study, we identified heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNP A2/B1) as an interacting partner of NS1 proteins by a proteomic method. Knockdown of hnRNP A2/B1 by small interfering RNA (siRNA) resulted in higher levels of NS vRNA, NS1 mRNA, and NS1 protein in the virus-infected cells. In addition, we demonstrated that hnRNP A2/B1 proteins are associated with NS1 and NS2 mRNAs and that knockdown of hnRNP A2/B1 promotes transport of NS1 mRNA from the nucleus to the cytoplasm in the infected cells. Lastly, we showed that knockdown of hnRNP A2/B1 leads to enhanced virus replication. Our results suggest that hnRNP A2/B1 plays an inhibitory role in the replication of influenza A virus in host cells potentially through suppressing NS1 RNA/protein levels and NS1 mRNA nucleocytoplasmic translocation. - Highlights: • Cellular protein hnRNP A2/B1 interacts with influenza viral protein NS1. • hnRNP A2/B1 suppresses the levels of NS1 protein, vRNA and mRNA in infected cells. • hnRNP A2/B1 protein is associated with NS1 and NS2 mRNAs. • hnRNP A2/B1 inhibits the nuclear export of NS1 mRNAs. • hnRNP A2/B1 inhibits influenza virus replication.

  10. Inactivation of purified rat liver cytochrome P-450 2B1 and rabbit liver cytochrome P-450 2B4 by N-methylcarbazole.

    PubMed

    Kuemmerle, S C; Shen, T; Hollenberg, P F

    1994-01-01

    Metabolism of N-methylcarbazole by purified rat liver cytochrome P-450 2B1 or rabbit liver P-450 2B4 resulted in the inactivation of these enzymes in a time-dependent, pseudo-first order manner as assayed spectrally by the decrease in the reduced CO spectrum at 450 nm. The inactivation was saturable with respect to the concentration of N-methylcarbazole, and a Ki = 5.2 microM and kINACT = 0.14 min-1 were determined for the inactivation of P-450 2B1. For P-450 2B4 inactivation, the Ki was 23 microM and the kINACT = 0.21 min-1. There was no increase in the reduced CO spectrum at 420 nm accompanying the inactivation, and the slight loss of the P-450 heme prosthetic group, as determined by the spectrum at 418 nm, was not sufficient to account for the loss of the reduced CO spectrum at 450 nm. The metabolism of N-methylcarbazole by P-450 did not result in the formation of a metabolic intermediate complex, which could also be responsible for the loss of cytochrome P-450 activity. Loss of catalytic activity for further substrate metabolism was also observed after preincubation of enzyme with N-methylcarbazole and the loss of catalytic activity correlated with the loss of the reduced CO spectrum. Accompanying the loss of spectrally detectable P-450 2B1 and P-450 2B4 catalytic activity, there was an increase in the NADPH oxidation rate. This increased rate persisted on subsequent addition of NADPH. PMID:8070309

  11. Transport of the soy isoflavone daidzein and its conjugative metabolites by the carriers SOAT, NTCP, OAT4, and OATP2B1.

    PubMed

    Grosser, Gary; Döring, Barbara; Ugele, Bernhard; Geyer, Joachim; Kulling, Sabine E; Soukup, Sebastian T

    2015-12-01

    Soy isoflavones (IF) are phytoestrogens, which interact with estrogen receptors. They are extensively metabolized by glucuronosyltransferases and sulfotransferases, leading to the modulation of their estrogenic activity. It can be assumed that this biotransformation also has a crucial impact on the uptake of IF by active or passive cellular transport mechanisms, but little is known about the transport of IF phase II metabolites into the cell. Therefore, transport assays for phase II metabolites of daidzein (DAI) were carried out using HEK293 cell lines transfected with five human candidate carriers, i.e., organic anion transporter OAT4, sodium-dependent organic anion transporter (SOAT), Na(+)-taurocholate cotransporting polypeptide (NTCP), apical sodium-dependent bile acid transporter ASBT, and organic anion transporting polypeptide OATP2B1. Cellular uptake was monitored by UHPLC-DAD. DAI monosulfates were transported by the carriers NTCP and SOAT in a sodium-dependent manner, while OAT4-HEK293 cells revealed a partly sodium-dependent transport for these compounds. In contrast, DAI-7,4'-disulfate was only taken up by NTCP-HEK293 cells. DAI-7-glucuronide, but not DAI-4'-glucuronide, was transported exclusively by OATP2B1 in a sodium-independent manner. DAI-7-glucuronide-4'-sulfate, DAI-7-glucoside, and DAI were no substrate of any of the tested carriers. In addition, the inhibitory potency of the DAI metabolites toward estrone-sulfate (E1S) uptake of the above-mentioned carriers was determined. In conclusion, human SOAT, NTCP, OATP2B1, and OAT4 were identified as carriers for the DAI metabolites. Several metabolites were able to inhibit carrier-dependent E1S uptake. These findings might contribute to a better understanding of the bioactivity of IF especially in case of hormone-related cancers. PMID:25319728

  12. Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1′-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism

    PubMed Central

    Probert, Philip M.; Palmer, Jeremy M.; Alhusainy, Wasma; Amer, Aimen O.; Rietjens, Ivonne M.C.M.; White, Steven A.; Jones, David E.; Wright, Matthew C.

    2016-01-01

    Rat B-13 progenitor cells are readily converted into functional hepatocyte-like B-13/H cells capable of phase I cytochrome P450-dependent activation of pro-carcinogens and induction of DNA damage. The aim of the present study was to investigate whether the cells are also capable of Phase II sulphotransferase (SULT)-dependent activation of a pro-carcinogen to an ultimate carcinogen. To this end we therefore examined the bioactivation of the model hepatic (hepato- and cholangio-) carcinogen estragole and its proximate SULT1A1-activated genotoxic metabolite 1′-hydroxyestragole. Exposing B-13 or B-13/H cells to estragole (at concentrations up to 1 mM) resulted in the production of low levels of 1′-hydroxyestragole, but did not result in detectable DNA damage. Exposing B-13/H cells – but not B-13 cells – to 1′-hydroxyestragole resulted in a dose-dependent increase in DNA damage in comet assays, confirmed by detection of N2-(trans-isoestragol-3′-yl)-2′-deoxyguanosine adducts. Genotoxicity was inhibited by general SULT inhibitors, supporting a role for SULTS in the activation of 1-hydroxyestragole in B-13/H cells. However, B-13 and B-13/H cells did not express biologically significant levels of SULT1A1 as determined by qRT-PCR, Western blotting and its associated 7-hydroxycoumarin sulphation activity. B-13 and B-13/H cells expressed – relative to intact rat liver – high levels of SULT2B1 (primarily the b isoform) and SULT4A1 mRNAs and proteins. B-13 and B-13/H cells also expressed the 3'-phosphoadenosine 5′-phosphosulphate synthase 1 required for the generation of activated sulphate cofactor 3′-phosphoadenosine 5′-phosphosulphate. However, only B-13/H cells expressed functional SULT activities towards SULT2B1 substrates DHEA, pregnenolone and 4 methylumbelliferone. Since liver progenitor cells are bi-potential and also form cholangiocytes, we therefore hypothesised that B-13 cells express a cholangiocyte-like SULT profile. To test this hypothesis

  13. Progenitor-derived hepatocyte-like (B-13/H) cells metabolise 1'-hydroxyestragole to a genotoxic species via a SULT2B1-dependent mechanism.

    PubMed

    Probert, Philip M; Palmer, Jeremy M; Alhusainy, Wasma; Amer, Aimen O; Rietjens, Ivonne M C M; White, Steven A; Jones, David E; Wright, Matthew C

    2016-01-22

    Rat B-13 progenitor cells are readily converted into functional hepatocyte-like B-13/H cells capable of phase I cytochrome P450-dependent activation of pro-carcinogens and induction of DNA damage. The aim of the present study was to investigate whether the cells are also capable of Phase II sulphotransferase (SULT)-dependent activation of a pro-carcinogen to an ultimate carcinogen. To this end we therefore examined the bioactivation of the model hepatic (hepato- and cholangio-) carcinogen estragole and its proximate SULT1A1-activated genotoxic metabolite 1'-hydroxyestragole. Exposing B-13 or B-13/H cells to estragole (at concentrations up to 1mM) resulted in the production of low levels of 1'-hydroxyestragole, but did not result in detectable DNA damage. Exposing B-13/H cells - but not B-13 cells - to 1'-hydroxyestragole resulted in a dose-dependent increase in DNA damage in comet assays, confirmed by detection of N(2)-(trans-isoestragol-3'-yl)-2'-deoxyguanosine adducts. Genotoxicity was inhibited by general SULT inhibitors, supporting a role for SULTS in the activation of 1-hydroxyestragole in B-13/H cells. However, B-13 and B-13/H cells did not express biologically significant levels of SULT1A1 as determined by qRT-PCR, Western blotting and its associated 7-hydroxycoumarin sulphation activity. B-13 and B-13/H cells expressed - relative to intact rat liver - high levels of SULT2B1 (primarily the b isoform) and SULT4A1 mRNAs and proteins. B-13 and B-13/H cells also expressed the 3'-phosphoadenosine 5'-phosphosulphate synthase 1 required for the generation of activated sulphate cofactor 3'-phosphoadenosine 5'-phosphosulphate. However, only B-13/H cells expressed functional SULT activities towards SULT2B1 substrates DHEA, pregnenolone and 4 methylumbelliferone. Since liver progenitor cells are bi-potential and also form cholangiocytes, we therefore hypothesised that B-13 cells express a cholangiocyte-like SULT profile. To test this hypothesis, the expression of SULTs

  14. A review and forecast of engine system research at the Army Propulsion Directorate

    NASA Technical Reports Server (NTRS)

    Bobula, George A.

    1989-01-01

    An account is given of the development status and achievements to date of the U.S. Army Propulsion Directorate's Small Turbine Engine Research (STER) programs, which are experimental investigations of the physics of entire engine systems from the viewpoints of component interactions and/or system dynamics. STER efforts are oriented toward the evaluation of complete turboshaft engine advanced concepts and are conducted at the ECRL-2 indoor, sea-level engine test facility. Attention is given to the results obtained by STER experiments concerned with IR-suppressing engine exhausts, a ceramic turbine-blade shroud, an active shaft-vibration control system, and a ceramic-matrix combustor liner.

  15. Fifteen Novel EIF2B1-5 Mutations Identified in Chinese Children with Leukoencephalopathy with Vanishing White Matter and a Long Term Follow-Up

    PubMed Central

    Zhang, Haihua; Dai, Lifang; Chen, Na; Zang, Lili; Leng, Xuerong; Du, Li; Wang, Jingmin; Jiang, Yuwu; Zhang, Feng; Wu, Xiru; Wu, Ye

    2015-01-01

    Leukoencephalopathy with vanishing white matter (VWM) is one of the most prevalent inherited childhood white matter disorders, which caused by mutations in each of the five subunits of eukaryotic translation initiation factor 2B (EIF2B1-5). In our study, 34 out of the 36 clinically diagnosed children (94%) were identified to have EIF2B1-5 mutations by sequencing. 15 novel mutations were identified. CNVs were not detected in patients with only one mutant allele and mutation-negative determined by gene sequencing. There is a significantly higher incidence of patients with EIF2B3 mutations compared with Caucasian patients (32% vs. 4%). c.1037T>C (p.Ile346Thr) in EIF2B3 was confirmed to be a founder mutation in Chinese, which probably one of the causes of the genotypic differences between ethnicities. Our average 4.4 years-follow-up on infantile, early childhood and juvenile VWM children suggested a rapid deterioration in motor function. Episodic aggravation was presented in 90% of infantile cases and 71.4% of childhood cases. 10 patients died during the follow-up. The Kaplan-Meier curve showed that the median survival time is 8.83 ± 1.51 years. This is the largest sample of children in a VWM follow-up study, which is helpful for a more depth understanding about the natural course. PMID:25761052

  16. Fifteen novel EIF2B1-5 mutations identified in Chinese children with leukoencephalopathy with vanishing white matter and a long term follow-up.

    PubMed

    Zhang, Haihua; Dai, Lifang; Chen, Na; Zang, Lili; Leng, Xuerong; Du, Li; Wang, Jingmin; Jiang, Yuwu; Zhang, Feng; Wu, Xiru; Wu, Ye

    2015-01-01

    Leukoencephalopathy with vanishing white matter (VWM) is one of the most prevalent inherited childhood white matter disorders, which caused by mutations in each of the five subunits of eukaryotic translation initiation factor 2B (EIF2B1-5). In our study, 34 out of the 36 clinically diagnosed children (94%) were identified to have EIF2B1-5 mutations by sequencing. 15 novel mutations were identified. CNVs were not detected in patients with only one mutant allele and mutation-negative determined by gene sequencing. There is a significantly higher incidence of patients with EIF2B3 mutations compared with Caucasian patients (32% vs. 4%). c.1037T>C (p.Ile346Thr) in EIF2B3 was confirmed to be a founder mutation in Chinese, which probably one of the causes of the genotypic differences between ethnicities. Our average 4.4 years-follow-up on infantile, early childhood and juvenile VWM children suggested a rapid deterioration in motor function. Episodic aggravation was presented in 90% of infantile cases and 71.4% of childhood cases. 10 patients died during the follow-up. The Kaplan-Meier curve showed that the median survival time is 8.83 ± 1.51 years. This is the largest sample of children in a VWM follow-up study, which is helpful for a more depth understanding about the natural course. PMID:25761052

  17. A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1

    PubMed Central

    Geissler, Rene; Simkin, Alfred; Floss, Doreen; Patel, Ravi; Fogarty, Elizabeth A.; Scheller, Jürgen; Grimson, Andrew

    2016-01-01

    3′-untranslated regions (UTRs) specify post-transcriptional fates of mammalian messenger RNAs (mRNAs), yet knowledge of the underlying sequences and mechanisms is largely incomplete. Here, we identify two related novel 3′ UTR motifs in mammals that specify transcript degradation. These motifs are interchangeable and active only within 3′ UTRs, where they are often preferentially conserved; furthermore, they are found in hundreds of transcripts, many encoding regulatory proteins. We found that degradation occurs via mRNA deadenylation, mediated by the CCR4–NOT complex. We purified trans factors that recognize the motifs and identified heterogeneous nuclear ribonucleoproteins (hnRNPs) A1 and A2/B1, which are required for transcript degradation, acting in a previously unknown manner. We used RNA sequencing (RNA-seq) to confirm hnRNP A1 and A2/B1 motif-dependent roles genome-wide, profiling cells depleted of these factors singly and in combination. Interestingly, the motifs are most active within the distal portion of 3′ UTRs, suggesting that their role in gene regulation can be modulated by alternative processing, resulting in shorter 3′ UTRs. PMID:27151978

  18. Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation.

    PubMed

    Hu, Jia; Chen, Zhong; Xia, Ding; Wu, Jia; Xu, Hua; Ye, Zhang-Qun

    2012-11-01

    Several recent reports have demonstrated that small activating dsRNA [double-stranded RNA; saRNA (small activating dsRNA)] complementary to promoter regions can up-regulate gene expression in mammalian cells, a phenomenon termed RNAa (RNA activation). However, the mechanism of RNAa remains obscure with regard to what is the target molecule for promoter-targeted saRNA and what are the proteins involved in this process. p21Waf1/Cip1 (p21) [CDKN1A (cyclin-dependent kinase inhibitor 1A)], an important tumour suppressor gene, is among the genes that can be activated by RNAa in tumour cells. In the present study, we provide direct evidence that p21 promoter-targeted saRNA interact with its intended target on the p21 promoter to activate p21 expression. This process is associated with recruitment of RNA polymerase II and AGO2 (argonaute 2) protein to the saRNA-target site. Additionally, we found that several hnRNPs (heterogeneous nuclear ribonucleoproteins) (A1, A2/B1 and C1/C2) are associated with saRNA. Further studies show that hnRNPA2/B1 interacts with the saRNA in vivo and in vitro and is required for RNAa activity. These findings indicate that RNAa results from specific targeting of promoters and reveals additional mechanistic details of RNAa. PMID:23035981

  19. Identification of hnRNPs K, L and A2/B1 as candidate proteins involved in the nutritional regulation of mRNA splicing

    PubMed Central

    Griffith, Brian N.; Walsh, Callee M.; Szeszel-Fedorowicz, Wioletta; Timperman, Aaron T.; Salati, Lisa M.

    2007-01-01

    Summary Nutrient regulation of glucose-6-phosphate dehydrogenase (G6PD) expression occurs through changes in the rate of splicing of G6PD pre-mRNA. This posttranscriptional mechanism accounts for the 12- to 15-fold increase in G6PD expression in livers of mice that were starved and then refed a high-carbohydrate diet. Regulation of G6PD pre-mRNA splicing requires a cis-acting element in exon 12 of the pre-mRNA. Using RNA probes to exon 12 and nuclear extracts from livers of mice that were starved or refed, proteins of 60 kDa and 37 kDa were detected bound to nucleotides 65–79 of exon 12 and this binding was decreased by 50% with nuclear extracts from refed mice. The proteins were identified as hnRNP K, and L, and hnRNP A2/B1 by LC-MS/MS. The decrease in binding of these proteins to exon 12 during refeeding was not accompanied by a decrease in the total amount of these proteins in total nuclear extract. HnRNPs K, L and A2/B1 have known roles in the regulation of mRNA splicing. The decrease in binding of these proteins during treatments that increase G6PD expression is consistent with a role for these proteins in the inhibition of G6PD mRNA splicing. PMID:17095106

  20. Wave Engine Topping Cycle Assessment

    NASA Technical Reports Server (NTRS)

    Welch, Gerard E.

    1996-01-01

    The performance benefits derived by topping a gas turbine engine with a wave engine are assessed. The wave engine is a wave rotor that produces shaft power by exploiting gas dynamic energy exchange and flow turning. The wave engine is added to the baseline turboshaft engine while keeping high-pressure-turbine inlet conditions, compressor pressure ratio, engine mass flow rate, and cooling flow fractions fixed. Related work has focused on topping with pressure-exchangers (i.e., wave rotors that provide pressure gain with zero net shaft power output); however, more energy can be added to a wave-engine-topped cycle leading to greater engine specific-power-enhancement The energy addition occurs at a lower pressure in the wave-engine-topped cycle; thus the specific-fuel-consumption-enhancement effected by ideal wave engine topping is slightly lower than that effected by ideal pressure-exchanger topping. At a component level, however, flow turning affords the wave engine a degree-of-freedom relative to the pressure-exchanger that enables a more efficient match with the baseline engine. In some cases, therefore, the SFC-enhancement by wave engine topping is greater than that by pressure-exchanger topping. An ideal wave-rotor-characteristic is used to identify key wave engine design parameters and to contrast the wave engine and pressure-exchanger topping approaches. An aerodynamic design procedure is described in which wave engine design-point performance levels are computed using a one-dimensional wave rotor model. Wave engines using various wave cycles are considered including two-port cycles with on-rotor combustion (valved-combustors) and reverse-flow and through-flow four-port cycles with heat addition in conventional burners. A through-flow wave cycle design with symmetric blading is used to assess engine performance benefits. The wave-engine-topped turboshaft engine produces 16% more power than does a pressure-exchanger-topped engine under the specified topping

  1. Dibenzosiloles and 12H-indololo[3,2-d]naphtho[1,2-b][1]siloles: exploration of organic chromophores exhibiting efficient solid-state fluorescence.

    PubMed

    Shimizu, Masaki

    2015-02-01

    The construction of a diorganosilylene bridge over a biaryl moiety at the 2,2'-positions is a versatile strategy for fine-tuning its HOMO-LUMO energy gap, which is closely linked to the electronic and optical properties of the compounds. Therefore, there is growing interest in the use of silicon-bridged biaryl motifs as key cores of various types of advanced functional materials, such as light-emitting, semiconducting, photovoltaic, and sensing materials. To accelerate the advances of materials based on silicon-bridged biaryls, it is essential to create new classes of biaryls and explore their functions and properties. This Personal Account describes recent research on the development of organic chromophores based on functionalized dibenzosiloles and 12H-indololo[3,2-d]naphtho[1,2-b][1]siloles as solid-state emitters. PMID:25504808

  2. Higher gene expression of CYP1A2, 2B1 and 2D2 in the brain of female compared with male rats.

    PubMed

    Nagai, K; Fukuno, S; Suzuki, H; Konishi, H

    2016-06-01

    Cytochrome P450 (CYP) in the brain plays an essential role in the local metabolism of various compounds, including clinically used drugs, toxins, and endogenous substances. In the present study, we compared the expression profiles of mRNAs for several CYP subtypes in the brain between male and female rats. The expression of CYP1A2, CYP2B1, and CYP2D2 in females was significantly higher than that in males. On the other hand, the expression level of the other CYP subtypes examined in the male brain was similar to that in the female brain. These results strongly suggest that marked gender differences exist in the expression profiles of some CYP subtypes in rat brain. PMID:27455552

  3. Consecutive thiophene-annulation approach to π-extended thienoacene-based organic semiconductors with [1]benzothieno[3,2-b][1]benzothiophene (BTBT) substructure.

    PubMed

    Mori, Takamichi; Nishimura, Takeshi; Yamamoto, Tatsuya; Doi, Iori; Miyazaki, Eigo; Osaka, Itaru; Takimiya, Kazuo

    2013-09-18

    We describe a new synthetic route to the [1]benzothieno[3,2-b][1]benzothiophene (BTBT) substructure featuring two consecutive thiophene-annulation reactions from o-ethynyl-thioanisole substrates and arylsulfenyl chloride reagents that can be easily derived from arylthiols. The method is particularly suitable for the synthesis of unsymmetrical derivatives, e.g., [1]benzothieno[3,2-b]naphtho[2,3-b]thiophene, [1]benzothieno[3,2-b]anthra[2,3-b]thiophene, and naphtho[3,2-b]thieno[3,2-b]anthra[2,3-b]thiophene, a selenium-containing derivative, [1]benzothieno[3,2-b][1]benzoselenophene. It also allows us to access largely π-extended derivatives with two BTBT substructures, e.g., bis[1]benzothieno[2,3-d:2',3'-d']benzo[1,2-b:4,5-b']dithiophene and bis[1]benzothieno[2,3-d:2',3'-d']naphtho[2,3-b:6,7-b']dithiophene (BBTNDT). It should be emphasized that these new BTBT derivatives are otherwise difficult to be synthesized. In addition, since various substrates and reagents, o-ethynyl-thioanisoles and arylthiols, respectively, can be combined, the method can be regarded as a versatile tool for the development of thienoacene-based organic semiconductors in this class. Among the newly synthesized materials, highly π-extended BBTNDT afforded very high mobility (>5 cm(2) V(-1) s(-1)) in its vapor-deposited organic field-effect transistors (OFETs), which is among the highest for unsubstituted acene- or thienoacenes-based organic semiconductors. In fact, the structural analyses of BBTNDT both in the single crystal and thin-film state indicated that an interactive two-dimensional molecular array is realized in the solid state, which rationalize the higher carrier mobility in the BBTNDT-based OFETs. PMID:24010738

  4. Evidence for Association between SH2B1 Gene Variants and Glycated Hemoglobin in Nondiabetic European American Young Adults: The Add Health Study.

    PubMed

    Lange, Leslie A; Graff, Mariaelisa; Lange, Ethan M; Young, Kristin L; Richardson, Andrea S; Mohlke, Karen L; North, Kari E; Harris, Kathleen M; Gordon-Larsen, Penny

    2016-09-01

    Glycated hemoglobin (HbA1c) is used to classify glycaemia and type 2 diabetes (T2D). Body mass index (BMI) is a predictor of HbA1c levels and T2D. We tested 43 established BMI and obesity loci for association with HbA1c in a nationally representative multiethnic sample of young adults from the National Longitudinal Study of Adolescent to Adult Health [Add Health: age 24-34 years; n = 5641 European Americans (EA); 1740 African Americans (AA); 1444 Hispanic Americans (HA)] without T2D, using two levels of covariate adjustment (Model 1: age, sex, smoking, and geographic region; Model 2: Model 1 covariates plus BMI). Bonferroni adjustment was made for 43 SNPs and we considered P < 0.0011 statistically significant. Means (SD) for HbA1c were 5.4% (0.3) in EA, 5.7% (0.4) in AA, and 5.5% (0.3) in HA. We observed significant evidence for association with HbA1c for two variants near SH2B1 in EA (rs4788102, P = 2.2 × 10(-4) ; rs7359397, P = 9.8 × 10(-4) ) for Model 1. Both results were attenuated after adjustment for BMI (rs4788102, P = 1.7 × 10(-3) ; rs7359397, P = 4.6 × 10(-3) ). No variant reached Bonferroni-corrected significance in AA or HA. These results suggest that SH2B1 polymorphisms are associated with HbA1c, largely independent of BMI, in EA young adults. PMID:27530450

  5. Variable cycle engine

    SciTech Connect

    Adamson, A.P.; Sprunger, E.V.

    1980-09-16

    A variable cycle turboshaft engine includes a remote fan system and respective high and low pressure systems for selectively driving the fan system in such a manner as to provide VTOL takeoff capability and minimum specific fuel consumption (SFC) at cruise and loiter conditions. For takeoff the fan system is primarily driven by the relatively large low pressure system whose combustor receives the motive fluid from a core bypass duct and, for cruise and loiter conditions, the fan system is driven by both a relatively small high pressure core and the low pressure system with its combustor inoperative. A mixer is disposed downstream of the high pressure system for mixing the relatively cold air from the bypass duct and the relatively hot air from the core prior to its flow to the low pressure turbine.

  6. Design, synthesis, and evaluation of 7H-thiazolo-[3,2-b]-1,2,4-triazin-7-one derivatives as dual binding site acetylcholinesterase inhibitors.

    PubMed

    Liu, Sijie; Shang, Ruofeng; Shi, Lanxiang; Zhou, Ran; He, Jingyu; Wan, David Chi-Cheong

    2014-08-01

    New dual binding site acetylcholinesterase (AChE) inhibitors have been designed and synthesized as a new drug candidate for the treatment of Alzheimer's disease (AD) through the binding to both catalytic and peripheral sites of the enzyme. Therefore, a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives 6a-j were synthesized and investigated for their ability to inhibit the activity of human AChE (hAChE) in comparison with huperzine-A. All the compounds were found to inhibit AChE activity, especially compounds 6c and 6i with the inhibition value of 76.10% and 77.82%, respectively. The molecular docking study indicated that they were nicely accommodated by AChE. The molecular docking study revealed that 6c and 6i possessed a more optimal binding conformation than 6a and can perfectly fit into the active and peripheral site of hAChE, and consequently exhibited highly improved inhibitor potency to hAChE. PMID:24890706

  7. Vavilosides A1/A2-B1/B2, new furostane glycosides from the bulbs of Allium vavilovii with cytotoxic activity.

    PubMed

    Zolfaghari, Behzad; Sadeghi, Masoud; Troiano, Raffaele; Lanzotti, Virginia

    2013-04-01

    A phytochemical analysis of the bulbs of Allium vavilovii M. Pop. & Vved. was attained for the first time extensively, affording to the isolation of four new furostanol saponins, named vavilosides A1/A2-B1/B2 (1a/b-2a/2b), as two couple of isomers in equilibrium, together with ascalonicoside A1/A2 (3a/3b) and 22-O-methyl ascalonicoside A1/A2 (4a/4b), previously isolated from shallot, Allium ascalonicum. High concentrations of kaempferol, kaempferide, and kaempferol 4(I)-glucoside were also isolated. The chemical structures of the new compounds, established through a combination of extensive nuclear magnetic resonance, mass spectrometry and chemical analyses, were identified as (25R)-furost-5(6)-en-1β,3β,22α,26-tetraol 1-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-galactopyranosyl 26-O-α-L-rhamnopyranoside (vaviloside A1), (25R)-furost-5(6)-en-1β,3β,22β,26-tetraol 1-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-galactopyranosyl 26-O-α-L-rhamnopyranoside (vaviloside A2), (25R)-furost-5(6)-en-1β,3β,22α,26-tetraol 1-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-xylopyranosyl 26-O-α-L-rhamnopyranoside (vaviloside B1), (25R)-furost-5(6)-en-1β,3β,22β,26-tetraol 1-O-α-L-rhamnopyranosyl-(1→2)-O-β-d-xylopyranosyl 26-O-α-L-rhamnopyranoside (vaviloside B2). The isolated saponins showed cytotoxic activity on J-774, murine monocyte/macrophage, and WEHI-164, murine fibrosarcoma, cell lines with the following rank: vaviloside B1/B2>ascalonicoside A1/A2>vaviloside A1/A2. PMID:23415085

  8. Laser excitation of O 2(b 1Σ g+, ν' = 0, 1, 2) - rates and channels of energy transfer and quenching

    NASA Astrophysics Data System (ADS)

    Wildt, J.; Bednarek, G.; Fink, E. H.; Wayne, R. P.

    1988-06-01

    Molecular oxygen was selectively excited to vibrational levels ν' =0, 1 and 2 of the b 1Σ g+ state by pulsed dye laser absorption in the (0,0), (1,0) and (2,0) bands of the b 1Σ g+ ← X 3Σ g- system in the near-infrared region. Time-resolved fluorescence was observed in the Δν=0 and -1 sequences of the b→X system near λ = 760 and 860 nm and in the (0,0) band of the a→X system at λ = 1270 nm. Lower limits have been deduced for the rate constants of vibrational relaxation in the b 1Σ g+ state and for electronic-to-electronic energy exchange of the b 1Σ g+ state energy between 16O 2 and 18O 2 isotopes. Rate constants for quenching of O 2 (b 1Σ g+, ν'=0) were remeasured for H 2, D 2, N 2, CO 2, and CH 4. From studies of the a→X emission intensity as a function of added gas pressure it was concluded that, with most gases, the b 1Σ g+ state is quenched to the a 1Δ g state with yields of ⩾ 90%. Measurements of the decay of the a→X band as a function of time at different O 2 pressures yielded a rate constant for self-quenching of the a 1Δ g state by O 2 of (1.5 ± 0.2) × 10 -18 cm 3 s -1.

  9. Overview of Lightweight Structures for Rotorcraft Engines and Drivetrains

    NASA Technical Reports Server (NTRS)

    Roberts, Gary D.

    2011-01-01

    This is an overview presentation of research being performed in the Advanced Materials Task within the NASA Subsonic Rotary Wing Project. This research is focused on technology areas that address both national goals and project goals for advanced rotorcraft. Specific technology areas discussed are: (1) high temperature materials for advanced turbines in turboshaft engines; (2) polymer matrix composites for lightweight drive system components; (3) lightweight structure approaches for noise and vibration control; and (4) an advanced metal alloy for lighter weight bearings and more reliable mechanical components. An overview of the technology in each area is discussed, and recent accomplishments are presented.

  10. Components for digitally controlled aircraft engines

    NASA Technical Reports Server (NTRS)

    Meador, J. D.

    1981-01-01

    Control system components suitable for use in digital electronic control systems are defined. Compressor geometry actuation concepts and fuel handling system concepts suitable for use in large high performance turbofan/turbojet engines are included. Eight conceptual system designs were formulated for the actuation of the compressor geometry. Six conceptual system designs were formulated for the engine fuel handling system. Assessment criteria and weighting factors were established and trade studies performed on their candidate systems to establish the relative merits of the various concepts. Fuel pumping and metering systems for small turboshaft engines were also studied. Seven conceptual designs were formulated, and trade studies performed. A simplified bypassing fuel metering scheme was selected and a preliminary design defined.

  11. The gate studies: Assessing the potential of future small general aviation turbine engines

    NASA Technical Reports Server (NTRS)

    Strack, W. C.

    1979-01-01

    Four studies were completed that explore the opportunities for future General Aviation turbine engines (GATE) in the 150-1000 SHP class. These studies forecasted the potential impact of advanced technology turbine engines in the post-1988 market, identified important aircraft and missions, desirable engine sizes, engine performance, and cost goals. Parametric evaluations of various engine cycles, configurations, design features, and advanced technology elements defined baseline conceptual engines for each of the important missions identified by the market analysis. Both fixed-wing and helicopter aircraft, and turboshaft, turboprop, and turbofan engines were considered. Sizable performance gains (e.g., 20% SFC decrease), and large engine cost reductions of sufficient magnitude to challenge the reciprocating engine in the 300-500 SHP class were predicted.

  12. Avco Lycoming quiet clean general aviation turbofan engine

    NASA Technical Reports Server (NTRS)

    Wilson, C. A.

    1980-01-01

    A fan module was developed using an existing turboshaft engine. The fan was designed using the latest in large engine noise control technology. A mixer was added to reduce the already low exhaust gas velocity. A nacelle incorporating sound treatment was provided for the test engine. A noise prediction model was used through the design process to evaluate the various design alternatives. Acoustic tests were then made to verify the prediction and identify the noise characteristics of the fan, core, jet, and sound treatment. Analysis of the recorded data yielded close agreement with the expected results. Core noise, as was expected, was the predominant source of noise for the quiet clean general aviation turbofan (QCGAT) engine. Flyover noise predictions were made which indicated that the Avco Lycoming QCGAT engine would meet the goals set for the QCGAT program.

  13. Effects of Nonalcoholic Fatty Liver Disease on Hepatic CYP2B1 and in Vivo Bupropion Disposition in Rats Fed a High-Fat or Methionine/Choline-Deficient Diet.

    PubMed

    Cho, Sung-Joon; Kim, Sang-Bum; Cho, Hyun-Jong; Chong, Saeho; Chung, Suk-Jae; Kang, Il-Mo; Lee, Jangik Ike; Yoon, In-Soo; Kim, Dae-Duk

    2016-07-13

    Nonalcoholic fatty liver disease (NAFLD) refers to hepatic pathologies, including simple fatty liver (SFL), nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis, that may progress to hepatocellular carcinoma. These liver disease states may affect the activity and expression levels of drug-metabolizing enzymes, potentially resulting in an alteration in the pharmacokinetics, therapeutic efficacy, and safety of drugs. This study investigated the hepatic cytochrome P450 (CYP) 2B1-modulating effect of a specific NAFLD state in dietary rat models. Sprague-Dawley rats were given a methionine/choline-deficient (MCD) or high-fat (HF) diet to induce NASH and SFL, respectively. The induction of these disease states was confirmed by plasma chemistry and liver histological analysis. Both the protein and mRNA levels of hepatic CYP2B1 were considerably reduced in MCD diet-fed rats; however, they were similar between the HF diet-fed and control rats. Consistently, the enzyme-kinetic and pharmacokinetic parameters for CYP2B1-mediated bupropion metabolism were considerably reduced in MCD diet-fed rats; however, they were also similar between the HF diet-fed and control rats. These results may promote a better understanding of the influence of NAFLD on CYP2B1-mediated metabolism, which could have important implications for the safety and pharmacokinetics of drug substrates for the CYP2B subfamily in patients with NAFLD. PMID:27321734

  14. Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin.

    PubMed

    Cho, Kyoung-In; Orry, Andrew; Park, Se Eun; Ferreira, Paulo A

    2015-08-19

    Cyclophilins are peptidyl cis-trans prolyl isomerases (PPIases), whose activity is typically inhibited by cyclosporine A (CsA), a potent immunosuppressor. Cyclophilins are also chaperones. Emerging evidence supports that cyclophilins present nonoverlapping PPIase and chaperone activities. The proteostasis of the disease-relevant substrates, signal transducer and activator of transcription 3 and 5 (STAT3/STAT5), heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1), and M-opsin, is regulated by nonoverlapping chaperone and PPIase activities of the cyclophilin domain (CY) of Ranbp2, a multifunctional and modular scaffold that controls nucleocytoplasmic shuttling and proteostasis of selective substrates. Although highly homologous, CY and the archetypal cyclophilin A (CyPA) present distinct catalytic and CsA-binding activities owing to unique structural features between these cylophilins. We explored structural idiosyncrasies between CY and CyPA to screen in silico nearly 9 million small molecules (SM) against the CY PPIase pocket and identify SMs with selective bioactivity toward STAT3, hnRNPA2B1, or M-opsin proteostasis. We found three classes of SMs that enhance the cytokine-stimulated transcriptional activity of STAT3 without changing latent and activated STAT3 levels, down-regulate hnRNPA2B1 or M-opsin proteostasis, or a combination of these. Further, a SM that suppresses hnRNPA2B1 proteostasis also inhibits strongly and selectively the PPIase activity of CY. This study unravels chemical probes for multimodal regulation of CY of Ranbp2 and its substrates, and this regulation likely results in the allosterism stemming from the interconversion of conformational substates of cyclophilins. The results also demonstrate the feasibility of CY in drug discovery against disease-relevant substrates controlled by Ranbp2, and they open new opportunities for therapeutic interventions. PMID:26030368

  15. 75 FR 59060 - Airworthiness Directives; Turboméca S.A. ARRIEL 2B Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-27

    .... SUPPLEMENTARY INFORMATION: On April 9, 2007, the FAA issued AD 2005-13- 25R1, Amendment 39-15028 (72 FR 19110... Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78). Examining the AD Docket You... rule'' under the DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3....

  16. 76 FR 56097 - Special Conditions: Pratt and Whitney Canada Model PT6C-67E Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-12

    ... July 7, 2011 (76 FR 39795). No comments were received. We added a statement to paragraph 2(c)(1) of the... search and rescue missions. The applicable airworthiness regulations do not contain adequate or... by the applicant to support rotorcraft search and rescue missions that require extensive...

  17. 75 FR 27411 - Airworthiness Directives; Turbomeca Arriel 1B, 1D, 1D1, and 1S1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-17

    ... INFORMATION: The FAA proposed to amend 14 CFR part 39 by superseding AD 2008-07-01, Amendment 39-15442 (73 FR... the proposed AD in the Federal Register on March 10, 2010 (75 FR 11072). That action proposed to...'' under DOT Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and (3) Will not have...

  18. 75 FR 11072 - Airworthiness Directives; Turbomeca Arriel 1B, 1D, 1D1, and 1S1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... Federal Register published on April 11, 2000 (65 FR 19477-78). Examining the AD Docket You may examine the.... Discussion On March 17, 2008, the FAA issued AD 2008-07-01, Amendment 39-15442 (73 FR 15866, March 26, 2008... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Would not have a...

  19. 75 FR 16022 - Airworthiness Directives; Turbomeca S.A. MAKILA 1A and 1A1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-31

    ... complete Privacy Act Statement in the Federal Register published on April 11, 2000 (65 FR 19477-78... AD would affect about 10 products of U.S. registry. We also estimate that it would take about 1 work-hour per product to comply with this proposed AD. The average labor rate is $85 per work-hour....

  20. 76 FR 39795 - Special Conditions: Pratt and Whitney Canada Model PT6C-67E Turboshaft Engine

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... continued airworthiness (ICA), and endurance testing. The ICA requirement is intended to address the unknown... assessment of the expected usage and publish ICA's and Airworthiness Limitations section limits in accordance.... (b) Section 33.4, Instructions for Continued Airworthiness (ICA). In addition to the requirements...

  1. Determination of O2(a1 delta g) and O2(b1 sigma+ g) yields in the reaction O + ClO --> Cl + O2: implications for photochemistry in the atmosphere of Venus

    NASA Technical Reports Server (NTRS)

    Leu, M. T.; Yung, Y. L.

    1987-01-01

    A discharge flow apparatus with chemiluminescence detector has been used to study the reaction O + ClO --> Cl + O2, where O2 = O2(a1 delta g) or O2(b1 sigma+ g). The measured quantum yields for producing O2(a1 delta g) and O2(b1 sigma+ g) in the above reaction are less than 2.5 x 10(-2) and equal to (4.4 +/- 1.1) x 10(-4), respectively. The observed O2(a1 delta g) airglow of Venus cannot be explained in the context of standard photochemistry using our experimental results and those reported in recent literature. The possibility of an alternative source of O atoms derived from SO2 photolysis in the mesosphere of Venus is suggested.

  2. Suppression of HPV-16 late L1 5′-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs

    PubMed Central

    Li, Xiaoze; Johansson, Cecilia; Glahder, Jacob; Mossberg, Ann-Kristin; Schwartz, Stefan

    2013-01-01

    Human papillomavirus type 16 (HPV-16) 5′-splice site SD3632 is used exclusively to produce late L1 mRNAs. We identified a 34-nt splicing inhibitory element located immediately upstream of HPV-16 late 5′-splice site SD3632. Two AUAGUA motifs located in these 34 nt inhibited SD3632. Two nucleotide substitutions in each of the HPV-16 specific AUAGUA motifs alleviated splicing inhibition and induced late L1 mRNA production from episomal forms of the HPV-16 genome in primary human keratinocytes. The AUAGUA motifs bind specifically not only to the heterogeneous nuclear RNP (hnRNP) D family of RNA-binding proteins including hnRNP D/AUF, hnRNP DL and hnRNP AB but also to hnRNP A2/B1. Knock-down of these proteins induced HPV-16 late L1 mRNA expression, and overexpression of hnRNP A2/B1, hnRNP AB, hnRNP DL and the two hnRNP D isoforms hnRNP D37 and hnRNP D40 further suppressed L1 mRNA expression. This inhibition may allow HPV-16 to hide from the immune system and establish long-term persistent infections with enhanced risk at progressing to cancer. There is an inverse correlation between expression of hnRNP D proteins and hnRNP A2/B1 and HPV-16 L1 production in the cervical epithelium, as well as in cervical cancer, supporting the conclusion that hnRNP D proteins and A2/B1 inhibit HPV-16 L1 mRNA production. PMID:24013563

  3. Genetics is a major determinant of expression of the human hepatic uptake transporter OATP1B1, but not of OATP1B3 and OATP2B1

    PubMed Central

    2013-01-01

    Background Organic anion transporting polypeptide (OATP) 1B1, OATP1B3, and OATP2B1 (encoded by SLCO1B1, SLCO1B3, SLCO2B1) mediate the hepatic uptake of endogenous compounds like bile acids and of drugs, for example, the lipid-lowering atorvastatin, thereby influencing hepatobiliary elimination. Here we systematically elucidated the contribution of SLCO variants on expression of the three hepatic OATPs under consideration of additional important covariates. Methods Expression was quantified by RT-PCR and immunoblotting in 143 Caucasian liver samples. A total of 109 rare and common variants in the SLCO1B3-SLCO1B1 genomic region and the SLCO2B1 gene were genotyped by MALDI-TOF mass spectrometry and genome-wide SNP microarray technology. SLCO1B1 haplotypes affecting hepatic OATP1B1 expression were associated with pharmacokinetic data of the OATP1B1 substrate atorvastatin (n = 82). Results Expression of OATP1B1, OATP1B3, and OATP2B1 at the mRNA and protein levels showed marked interindividual variability. All three OATPs were expressed in a coordinated fashion. By a multivariate regression analysis adjusted for non-genetic and transcription covariates, increased OATP1B1 expression was associated with the coding SLCO1B1 variant c.388A > G (rs2306283) even after correction for multiple testing (P = 0.00034). This held true for haplotypes harboring c.388A > G but not the functional variant c.521T > C (rs4149056) associated with statin-related myopathy. c.388A > G also significantly affected atorvastatin pharmacokinetics. SLCO variants and non-genetic and regulatory covariates together accounted for 59% of variability of OATP1B1 expression. Conclusions Our results show that expression of OATP1B1, but not of OATP1B3 and OATP2B1, is significantly affected by genetic variants. The SLCO1B1 variant c.388A > G is the major determinant with additional consequences on atorvastatin plasma levels. PMID:23311897

  4. Jet Engine Noise Generation, Prediction and Control. Chapter 86

    NASA Technical Reports Server (NTRS)

    Huff, Dennis L.; Envia, Edmane

    2004-01-01

    Aircraft noise has been a problem near airports for many years. It is a quality of life issue that impacts millions of people around the world. Solving this problem has been the principal goal of noise reduction research that began when commercial jet travel became a reality. While progress has been made in reducing both airframe and engine noise, historically, most of the aircraft noise reduction efforts have concentrated on the engines. This was most evident during the 1950 s and 1960 s when turbojet engines were in wide use. This type of engine produces high velocity hot exhaust jets during takeoff generating a great deal of noise. While there are fewer commercial aircraft flying today with turbojet engines, supersonic aircraft including high performance military aircraft use engines with similar exhaust flow characteristics. The Pratt & Whitney F100-PW-229, pictured in Figure la, is an example of an engine that powers the F-15 and F-16 fighter jets. The turbofan engine was developed for subsonic transports, which in addition to better fuel efficiency also helped mitigate engine noise by reducing the jet exhaust velocity. These engines were introduced in the late 1960 s and power most of the commercial fleet today. Over the years, the bypass ratio (that is the ratio of the mass flow through the fan bypass duct to the mass flow through the engine core) has increased to values approaching 9 for modern turbofans such as the General Electric s GE-90 engine (Figure lb). The benefits to noise reduction for high bypass ratio (HPBR) engines are derived from lowering the core jet velocity and temperature, and lowering the tip speed and pressure ratio of the fan, both of which are the consequences of the increase in bypass ratio. The HBPR engines are typically very large in diameter and can produce over 100,000 pounds of thrust for the largest engines. A third type of engine flying today is the turbo-shaft which is mainly used to power turboprop aircraft and helicopters

  5. Toward a Real-Time Measurement-Based System for Estimation of Helicopter Engine Degradation Due to Compressor Erosion

    NASA Technical Reports Server (NTRS)

    Litt, Jonathan S.; Simo, Donald L.

    2007-01-01

    This paper presents a preliminary demonstration of an automated health assessment tool, capable of real-time on-board operation using existing engine control hardware. The tool allows operators to discern how rapidly individual turboshaft engines are degrading. As the compressor erodes, performance is lost, and with it the ability to generate power. Thus, such a tool would provide an instant assessment of the engine s fitness to perform a mission, and would help to pinpoint any abnormal wear or performance anomalies before they became serious, thereby decreasing uncertainty and enabling improved maintenance scheduling. The research described in the paper utilized test stand data from a T700-GE-401 turboshaft engine that underwent sand-ingestion testing to scale a model-based compressor efficiency degradation estimation algorithm. This algorithm was then applied to real-time Health Usage and Monitoring System (HUMS) data from a T700-GE-701C to track compressor efficiency on-line. The approach uses an optimal estimator called a Kalman filter. The filter is designed to estimate the compressor efficiency using only data from the engine s sensors as input.

  6. Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay

    PubMed Central

    2010-01-01

    Background In addition to acting as an RNA quality control pathway, nonsense-mediated mRNA decay (NMD) plays roles in regulating normal gene expression. In particular, the extent to which alternative splicing is coupled to NMD and the roles of NMD in regulating uORF containing transcripts have been a matter of debate. Results In order to achieve a greater understanding of NMD regulated gene expression we used 2D-DiGE proteomics technology to examine the changes in protein expression induced in HeLa cells by UPF1 knockdown. QPCR based validation of the corresponding mRNAs, in response to both UPF1 knockdown and cycloheximide treatment, identified 17 bona fide NMD targets. Most of these were associated with bioinformatically predicted NMD activating features, predominantly upstream open reading frames (uORFs). Strikingly, however, the majority of transcripts up-regulated by UPF1 knockdown were either insensitive to, or even down-regulated by, cycloheximide treatment. Furthermore, the mRNA abundance of several down-regulated proteins failed to change upon UPF1 knockdown, indicating that UPF1's role in regulating mRNA and protein abundance is more complex than previously appreciated. Among the bona fide NMD targets, we identified a highly conserved AS-NMD event within the 3' UTR of the HNRNPA2B1 gene. Overexpression of GFP tagged hnRNP A2 resulted in a decrease in endogenous hnRNP A2 and B1 mRNA with a concurrent increase in the NMD sensitive isoforms. Conclusions Despite the large number of changes in protein expression upon UPF1 knockdown, a relatively small fraction of them can be directly attributed to the action of NMD on the corresponding mRNA. From amongst these we have identified a conserved AS-NMD event within HNRNPA2B1 that appears to mediate autoregulation of HNRNPA2B1 expression levels. PMID:20946641

  7. Determination of O2(a1Delta g) and O2(b1Sigma + g) yields in the reaction O + ClO yields Cl + O2 - Implications for photochemistry in the atmosphere of Venus

    NASA Technical Reports Server (NTRS)

    Leu, Ming-Taun; Yung, Yuk L.

    1987-01-01

    A discharge flow apparatus with a chemiluminescence detector was used to investigate the reaction O + ClO yields Cl + O2(asterisk), where O2(asterisk) = O2(a1Delta g) or O2(b1Sigma + g). It is found that the observed O2(a1Delta g) airglow of Venus cannot be explained in the framework of standard photochemistry using the experimental results obtained here and those reported in the recent literature. The possibility of an alternative source of O atoms derived from SO2 photolysis in the Venus mesosphere is suggested.

  8. The translational, rotational, and vibrational energy effects on the chemical reactivity of water cation H2O+(X 2B1) in the collision with deuterium molecule D2

    NASA Astrophysics Data System (ADS)

    Xu, Yuntao; Xiong, Bo; Chang, Yih Chung; Ng, C. Y.

    2013-07-01

    By employing the newly established vacuum ultraviolet (VUV) laser pulsed field ionization-photoion (PFI-PI) double quadrupole-double octopole ion guide apparatus, we have examined the translational, rotational, and vibrational energy effects on the chemical reactivity of water cation H2O+(X2B1) in the collision with deuterium molecule D2. The application of a novel electric-field pulsing scheme to the VUV laser PFI-PI ion source has enabled the preparation of a rovibrationally selected H2O+(X2B1; v_1^ + v_2^ + v_3^ +; N+Ka+Kc+) ion beam with not only high internal-state selectivity and high intensity but also high translational energy resolution. Despite the unfavorable Franck-Condon factors, we are able to prepare the excited vibrational states (v_1^ + v_2^ + v_3^ +) = (100) and (020) along with the (000) ground vibrational state, for collisional studies, where v_1^ +, v_2^ +, and v_3^ + represent the symmetric stretching, bending, and asymmetric stretching modes of H2O+(X2B1). We show that a range of rotational levels from N+Ka+Kc+ = 000 to 322, covering a rotational energy range of 0-200 cm-1 of these vibrational states, can also be generated for absolute integral cross section (σ) measurements at center-of-mass collision energies (Ecms) from thermal energies to 10.00 eV. The Ecm dependences of the σ values are consistent with the prediction of the orbiting model, indicating that translational energy significantly hinders the chemical reactivity of H2O+(X2B1). Rotational enhancements are observed at Ecm < 0.30 eV for all the three vibrational states, (000), (100), and (020). While the σ values for (100) are found to be only slightly below those for (000), the σ values for (020) are lower than those for (000) and (100) by up to 20% at Ecm ≤ 0.20 eV, indicative of vibrational inhibition at low Ecm by excitation of the (020) mode. Rationalizations are proposed for the observed rotational enhancements and the bending vibrational inhibition. Rigorous

  9. The translational, rotational, and vibrational energy effects on the chemical reactivity of water cation H2O+(X 2B1) in the collision with deuterium molecule D2.

    PubMed

    Xu, Yuntao; Xiong, Bo; Chang, Yih Chung; Ng, C Y

    2013-07-14

    By employing the newly established vacuum ultraviolet (VUV) laser pulsed field ionization-photoion (PFI-PI) double quadrupole-double octopole ion guide apparatus, we have examined the translational, rotational, and vibrational energy effects on the chemical reactivity of water cation H2O(+)(X(2)B1) in the collision with deuterium molecule D2. The application of a novel electric-field pulsing scheme to the VUV laser PFI-PI ion source has enabled the preparation of a rovibrationally selected H2O(+)(X(2)B1; v1 (+)v2 (+)v3 (+); N(+) K a+Kc+) ion beam with not only high internal-state selectivity and high intensity but also high translational energy resolution. Despite the unfavorable Franck-Condon factors, we are able to prepare the excited vibrational states (v1 (+)v2 (+)v3 (+))=(100) and (020) along with the (000) ground vibrational state, for collisional studies, where v1 (+), v2 (+), and v3 (+) represent the symmetric stretching, bending, and asymmetric stretching modes of H2O(+)(X(2)B1). We show that a range of rotational levels from N(+) K a+Kc+ = 000 to 322, covering a rotational energy range of 0-200 cm(-1) of these vibrational states, can also be generated for absolute integral cross section (σ) measurements at center-of-mass collision energies (Ecms) from thermal energies to 10.00 eV. The Ecm dependences of the σ values are consistent with the prediction of the orbiting model, indicating that translational energy significantly hinders the chemical reactivity of H2O(+)(X(2)B1). Rotational enhancements are observed at Ecm < 0.30 eV for all the three vibrational states, (000), (100), and (020). While the σ values for (100) are found to be only slightly below those for (000), the σ values for (020) are lower than those for (000) and (100) by up to 20% at Ecm ≤ 0.20 eV, indicative of vibrational inhibition at low Ecm by excitation of the (020) mode. Rationalizations are proposed for the observed rotational enhancements and the bending vibrational

  10. Pyrrolo[1,2-b][1,2,5]benzothiadiazepines (PBTDs): A new class of agents with high apoptotic activity in chronic myelogenous leukemia K562 cells and in cells from patients at onset and who were imatinib-resistant.

    PubMed

    Silvestri, Romano; Marfè, Gabriella; Artico, Marino; La Regina, Giuseppe; Lavecchia, Antonio; Novellino, Ettore; Morgante, Emanuela; Morgante, Manuela; Di Stefano, Carla; Catalano, Gianfranco; Filomeni, Giuseppe; Abruzzese, Elisabetta; Ciriolo, Maria Rosa; Russo, Matteo Antonio; Amadori, Sergio; Cirilli, Roberto; La Torre, Francesco; Sinibaldi Salimei, Paola

    2006-09-21

    Pyrrolo[1,2-b][1,2,5]benzothiadiazepine 5,5-dioxides (PBTDs) induced apoptosis in human BCR-ABL-expressing leukemia cells. The apoptotic activity was also observed in primary leukemic blasts, obtained from chronic myelogenous leukemia (CML) patients at onset or from patients in blast crisis and who were imatinib-resistant. Compounds 5 and 14 induced apoptosis before BCR-ABL protein expression and tyrosin phosphorylation were affected and activated different caspases in the apoptotic pathway. PBTDs are a new class of valid candidates for the treatment of CML. PMID:16970408

  11. Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats.

    PubMed

    Kobayashi, Misato; Hoshinaga, Yukiko; Miura, Natsuko; Tokuda, Yuki; Shigeoka, Shigeru; Murai, Atsushi; Horio, Fumihiko

    2014-01-01

    The mechanisms underlying the decrease in hepatic cytochrome P-450 (CYP) content in ascorbic acid deficiency was investigated in scurvy-prone ODS rats. First, male ODS rats were fed a diet containing sufficient ascorbic acid (control) or a diet without ascorbic acid (deficient) for 18 days, with or without the intraperitoneal injection of phenobarbital. Ascorbic acid deficiency decreased hepatic microsomal total CYP content, CYP2B1/2B2 protein, and mitochondrial cytochrome oxidase (COX) complex IV subunit I protein, and simultaneously increased heme oxygenase-1 protein in microsomes and mitochondria. Next, heme oxygenase-1 inducers, that is lipopolysaccharide and hemin, were administered to phenobaribital-treated ODS rats fed sufficient ascorbic acid. The administration of these inducers decreased hepatic microsomal total CYP content, CYP2B1/2B2 protein, and mitochondrial COX complex IV subunit I protein. These results suggested that the stimulation of hepatic heme oxygenase-1 expression by ascorbic acid deficiency caused the decrease in CYP content in liver. PMID:25036135

  12. Communication: Rovibrationally selected absolute total cross sections for the reaction H2O+(X2B1; v1+v2+v3+ = 000; N+Ka+Kc+) + D2: Observation of the rotational enhancement effect

    NASA Astrophysics Data System (ADS)

    Xu, Yuntao; Xiong, Bo; Chang, Yih Chung; Ng, C. Y.

    2012-12-01

    By employing the newly established vacuum ultraviolet laser pulsed field ionization-photoion (PFI-PI) double quadrupole-double octopole ion guide apparatus, we have measured the rovibrationally selected absolute total cross sections of the ion-molecule reaction H2O+(X2B1; v1+v2+v3+ = 000; N+Ka+Kc+) + D2 → H2DO+ + D in the center-of-mass collision energy (Ecm) range of 0.05-10.00 eV. The pulsing scheme used for the generation of PFI-PIs has made possible the preparation of reactant H2O+(X2B1; v1+v2+v3+ = 000) ions in single N+Ka+Kc+ rotational levels with high kinetic energy resolutions. The absolute total cross sections observed in different N+Ka+Kc+ levels with rotational energies in the range of 0-200 cm-1 were found to exhibit a significant rotational enhancement on the reactivity for the titled reaction. In contrast, the measured cross sections reveal a decreasing trend with increasing Ecm, indicating that the rotational enhancement observed is not a total energy effect, but a dynamical effect. Furthermore, the rotational enhancement is found to be more pronounced as Ecm is decreased. This experiment provided evidence that the coupling of the core rotational angular momentum with the orbital angular momentum could play a role in chemical reactivity, particularly at low Ecm.

  13. Jet engine noise and infrared plume correlation field campaign

    NASA Astrophysics Data System (ADS)

    Cunio, Phillip M.; Weber, Reed A.; Knobel, Kimberly R.; Smith, Christine; Draudt, Andy

    2015-09-01

    Jet engine noise can be a health hazard and environmental pollutant, particularly affecting personnel working in close proximity to jet engines, such as airline mechanics. Mitigating noise could reduce the potential for hearing loss in runway workers; however, there exists a very complex relationship between jet engine design parameters, operating conditions, and resultant noise power levels, and understanding and characterizing this relationship is a key step in mitigating jet engine noise effects. We demonstrate initial results highlighting the utility of high-speed imaging (hypertemporal imaging) in correlating the infrared signatures of jet engines with acoustic noise. This paper builds on prior theoretical analysis of jet engine infrared signatures and their potential relationships to jet engine acoustic emissions. This previous work identified the region of the jet plume most likely to emit both in infrared and in acoustic domains, and it prompted the investigation of wave packets as a physical construct tying together acoustic and infrared energy emissions. As a means of verifying these assertions, a field campaign to collect relevant data was proposed, and data collection was carried out with a bank of infrared instruments imaging a T700 turboshaft engine undergoing routine operational testing. The detection of hypertemporal signatures in association with acoustic signatures of jet engines enables the use of a new domain in characterizing jet engine noise. This may in turn enable new methods of predicting or mitigating jet engine noise, which could lead to socioeconomic benefits for airlines and other operators of large numbers of jet engines.

  14. Engine

    SciTech Connect

    Shin, H.B.

    1984-02-28

    An internal combustion engine has a piston rack depending from each piston. This rack is connected to a power output shaft through a mechanical rectifier so that the power output shaft rotates in only one direction. A connecting rod is pivotally connected at one end to the rack and at the other end to the crank of a reduced function crankshaft so that the crankshaft rotates at the same angular velocity as the power output shaft and at the same frequency as the pistons. The crankshaft has a size, weight and shape sufficient to return the pistons back into the cylinders in position for the next power stroke.

  15. Performance Benefits for Wave Rotor-Topped Gas Turbine Engines

    NASA Technical Reports Server (NTRS)

    Jones, Scott M.; Welch, Gerard E.

    1996-01-01

    The benefits of wave rotor-topping in turboshaft engines, subsonic high-bypass turbofan engines, auxiliary power units, and ground power units are evaluated. The thermodynamic cycle performance is modeled using a one-dimensional steady-state code; wave rotor performance is modeled using one-dimensional design/analysis codes. Design and off-design engine performance is calculated for baseline engines and wave rotor-topped engines, where the wave rotor acts as a high pressure spool. The wave rotor-enhanced engines are shown to have benefits in specific power and specific fuel flow over the baseline engines without increasing turbine inlet temperature. The off-design steady-state behavior of a wave rotor-topped engine is shown to be similar to a conventional engine. Mission studies are performed to quantify aircraft performance benefits for various wave rotor cycle and weight parameters. Gas turbine engine cycles most likely to benefit from wave rotor-topping are identified. Issues of practical integration and the corresponding technical challenges with various engine types are discussed.

  16. Feasibility study for convertible engine torque converter

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The feasibility study has shown that a dump/fill type torque converter has excellent potential for the convertible fan/shaft engine. The torque converter space requirement permits internal housing within the normal flow path of a turbofan engine at acceptable engine weight. The unit permits operating the engine in the turboshaft mode by decoupling the fan. To convert to turbofan mode, the torque converter overdrive capability bring the fan speed up to the power turbine speed to permit engagement of a mechanical lockup device when the shaft speed are synchronized. The conversion to turbofan mode can be made without drop of power turbine speed in less than 10 sec. Total thrust delivered to the aircraft by the proprotor, fan, and engine during tansient can be controlled to prevent loss of air speed or altitude. Heat rejection to the oil is low, and additional oil cooling capacity is not required. The turbofan engine aerodynamic design is basically uncompromised by convertibility and allows proper fan design for quiet and efficient cruise operation. Although the results of the feasibility study are exceedingly encouraging, it must be noted that they are based on extrapolation of limited existing data on torque converters. A component test program with three trial torque converter designs and concurrent computer modeling for fluid flow, stress, and dynamics, updated with test results from each unit, is recommended.

  17. Mass spectroscopy identifies the splicing-associated proteins, PSF, hnRNP H3, hnRNP A2/B1, and TLS/FUS as interacting partners of the ZNF198 protein associated with rearrangement in myeloproliferative disease

    SciTech Connect

    Kasyapa, Chitta S.; Kunapuli, Padmaja; Cowell, John K. . E-mail: John.Cowell@RoswellPark.org

    2005-09-10

    ZNF198 is fused with FGFR1 in an atypical myeloproliferative disease that results in constitutive activation of the kinase domain and mislocalization to the cytoplasm. We have used immunoprecipitation of a GFP-tagged ZNF198 combined with MALDI-TOF mass spectroscopy to identify interacting proteins. P splicing factor (PSF) was identified as one of the proteins and this interaction was confirmed by Western blotting. Other proteins identified were the spliceosomal components hnRNP A2/B1, hnRNP H3, and TLS/FUS. PSF is also known to interact with PTB, another member of the hnRNP family of proteins, and we further demonstrated that PTB interacts with ZNF198. The interaction between TLS/FUS and ZNF198 was confirmed using Western blot analysis. In 293 cells expressing the ZNF198/FGFR1 fusion protein, neither PSF nor PTB binds to the fusion protein, possibly because of their differential localization in the cell.

  18. Study of an advanced General Aviation Turbine Engine (GATE)

    NASA Technical Reports Server (NTRS)

    Gill, J. C.; Short, F. R.; Staton, D. V.; Zolezzi, B. A.; Curry, C. E.; Orelup, M. J.; Vaught, J. M.; Humphrey, J. M.

    1979-01-01

    The best technology program for a small, economically viable gas turbine engine applicable to the general aviation helicopter and aircraft market for 1985-1990 was studied. Turboshaft and turboprop engines in the 112 to 746 kW (150 to 1000 hp) range and turbofan engines up to 6672 N (1500 lbf) thrust were considered. A good market for new turbine engines was predicted for 1988 providing aircraft are designed to capitalize on the advantages of the turbine engine. Parametric engine families were defined in terms of design and off-design performance, mass, and cost. These were evaluated in aircraft design missions selected to represent important market segments for fixed and rotary-wing applications. Payoff parameters influenced by engine cycle and configuration changes were aircraft gross mass, acquisition cost, total cost of ownership, and cash flow. Significant advantage over a current technology, small gas turbine engines was found especially in cost of ownership and fuel economy for airframes incorporating an air-cooled high-pressure ratio engine. A power class of 373 kW (500 hp) was recommended as the next frontier for technology advance where large improvements in fuel economy and engine mass appear possible through component research and development.

  19. The influence of engine/transmission/governor on tilting proprotor aircraft dynamics

    NASA Technical Reports Server (NTRS)

    Johnson, W.

    1975-01-01

    An analytical model is developed for the dynamics of a tilting proprotor aircraft engine and drive train, including a rotor speed governor and interconnect shaft. The dynamic stability of a proprotor and cantilever wing is calculated, including the engine-transmission-governor model. It is concluded that the rotor behaves much as if windmilling as far as its dynamic behavior is concerned, with some influence of the turboshaft engine inertia and damping. The interconnect shaft has a significant influence on the antisymmetric dynamics of proprotor aircraft. The proprotor aerodynamics model is extended to include reverse flow, and a refinement on the method used to calculate the kinematic pitch-bending coupling of the blade is developed.

  20. KONFIG and REKONFIG: Two interactive preprocessing to the Navy/NASA Engine Program (NNEP)

    NASA Technical Reports Server (NTRS)

    Fishbach, L. H.

    1981-01-01

    The NNEP is a computer program that is currently being used to simulate the thermodynamic cycle performance of almost all types of turbine engines by many government, industry, and university personnel. The NNEP uses arrays of input data to set up the engine simulation and component matching method as well as to describe the characteristics of the components. A preprocessing program (KONFIG) is described in which the user at a terminal on a time shared computer can interactively prepare the arrays of data required. It is intended to make it easier for the occasional or new user to operate NNEP. Another preprocessing program (REKONFIG) in which the user can modify the component specifications of a previously configured NNEP dataset is also described. It is intended to aid in preparing data for parametric studies and/or studies of similar engines such a mixed flow turbofans, turboshafts, etc.

  1. Establishing a Ballistic Test Methodology for Documenting the Containment Capability of Small Gas Turbine Engine Compressors

    NASA Technical Reports Server (NTRS)

    Heady, Joel; Pereira, J. Michael; Ruggeri, Charles R.; Bobula, George A.

    2009-01-01

    A test methodology currently employed for large engines was extended to quantify the ballistic containment capability of a small turboshaft engine compressor case. The approach involved impacting the inside of a compressor case with a compressor blade. A gas gun propelled the blade into the case at energy levels representative of failed compressor blades. The test target was a full compressor case. The aft flange was rigidly attached to a test stand and the forward flange was attached to a main frame to provide accurate boundary conditions. A window machined in the case allowed the projectile to pass through and impact the case wall from the inside with the orientation, direction and speed that would occur in a blade-out event. High-peed, digital-video cameras provided accurate velocity and orientation data. Calibrated cameras and digital image correlation software generated full field displacement and strain information at the back side of the impact point.

  2. The mechanism of stimulation of NADPH oxidation during the mechanism-based inactivation of cytochrome P450 2B1 by N-methylcarbazole: redox cycling and DNA scission.

    PubMed

    Shen, T; Hollenberg, P F

    1994-01-01

    The oxidation rate of NADPH is markedly stimulated during the mechanism-based inactivation of cytochrome P450 2B1 by N-methylcarbazole (NMC) in a reconstituted system consisting of NADPH-cytochrome P450 reductase, cytochrome P450 and phospholipid. The stimulation of NADPH oxidation in this system is due to 1-hydroxy-N-methylcarbazole (1-OH-NMC), one of the major metabolites of NMC. The 1-OH-NMC is further metabolized in an NADPH-dependent manner by the reconstituted system or by purified NADPH-cytochrome P450 reductase to give a more polar metabolite which has been isolated by HPLC. The conversion of 1-OH-NMC to this product was inhibited by superoxide dismutase (SOD), and incubation of the 1-OH-NMC with hypoxanthine-xanthine oxidase resulted in the formation of the same product, suggesting that the superoxide anion was involved in the metabolism of 1-OH-NMC by the reductase. Redox cycling activity during the metabolism of 1-OH-NMC by reductase has been demonstrated. The oxidation of NADPH by the reductase in the presence of 35 microM 1-OH-NMC was enhanced approximately 23-fold [240 nmol of NADPH oxidized/(min.nmol of reductase)] relative to control levels in the presence of 500 microM NMC [10.5 nmol/(min.nmol of reductase)]. 1-OH-NMC (35 microM) caused a 40-fold increase in the rate of formation of superoxide during its metabolism by reductase. The rapid rates of NADPH oxidation and superoxide formation were inhibited by the addition of reduced glutathione (GSH) to the reaction mixture. Neither SOD nor GSH inhibited the reductase activity directly.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8199313

  3. Ultraviolet Photodissociation Dynamics of the Allyl Radical via the B̃(2)A1(3s), C̃(2)B2(3py), and Ẽ(2)B1(3px) Electronic Excited States.

    PubMed

    Song, Yu; Lucas, Michael; Alcaraz, Maria; Zhang, Jingsong; Brazier, Christopher

    2015-12-17

    Ultraviolet (UV) photodissociation dynamics of jet-cooled allyl radical via the B̃(2)A1(3s), C̃(2)B2(3py), and Ẽ(2)B1(3px) electronically excited states are studied at the photolysis wavelengths from 249 to 216 nm using high-n Rydberg atom time-of-flight (HRTOF) and resonance-enhanced multiphoton ionization (REMPI) techniques. The photofragment yield (PFY) spectra of the H atom products are measured using both allyl chloride and 1,5-hexadiene as precursors of the allyl radical and show a broad peak centered near 228 nm, whereas the previous UV absorption spectra of the allyl radical peak around 222 nm. This difference suggests that, in addition to the H + C3H4 product channel, another dissociation channel (likely CH3 + C2H2) becomes significant with increasing excitation energy. The product translational energy release of the H + C3H4 products is modest, with the P(ET) distributions peaking near 8.5 kcal/mol and the fraction of the average translational energy in the total excess energy, ⟨fT⟩, in the range 0.22-0.18 from 249 to 216 nm. The P(ET)'s are consistent with production of H + allene and H + propyne, as suggested by previous experimental and theoretical studies. The angular distributions of the H atom products are isotropic, with the anisotropy parameter β ≈ 0. The H atom dissociation rate constant from the pump-probe study gives a lower limit of 1 × 10(8)/s. The dissociation mechanism is consistent with unimolecular decomposition of the hot allyl radical on the ground electronic state after internal conversion of the electronically excited state. PMID:26334360

  4. Mass spectra of the 2,4-pentadiynylidyne (C5H; X2[Pi]) and 2,4-pentadiynyl-1 (n-C5H3; X2B1) radicals

    NASA Astrophysics Data System (ADS)

    Gu, Xibin; Guo, Ying; Kaiser, Ralf I.

    2007-03-01

    We employed the crossed molecular beams method to synthesize the 2,4-pentadiynylidyne, C5H (X2[Pi]), and the 2,4-pentadiynyl-1, n-C5H3(X2B1), radicals in situ under single collision conditions via the reactions of tricarbon molecules with acetylene and ethylene, respectively. Time-of-flight spectra of the radicals were recorded at the center-of-mass angles at various mass-to-charge ratios from m/z = 63 (C5H3+) to m/z = 36 (C3+). Integrating these time-of-flight spectra and normalizing them to the most intense peak, intensity ratios of I(m/z = 61):I(m/z = 60):I(m/z = 49):I(m/z = 48):I(m/z = 37):I(m/z = 36) = 0.49 ± 0.04:0.27 ± 0.03:1:0.15 ± 0.02:0.32 ± 0.03:0.11 ± 0.04 can be extracted for the 2,4-pentadiynylidyne radical. In case of the 2,4-pentadiynyl-1 molecule, we find intensity ratios of I(m/z = 63):I(m/z = 62):I(m/z = 61):I(m/z = 60):I(m/z = 51):I(m/z = 50):I(m/z = 49):I(m/z = 48):I(m/z = 39):I(m/z = 38):I(m/z = 37):I(m/z = 36) = 0.39 ± 0.04:0.50 ± 0.05:0.32 ± 0.03:0.10 ± 0.03:0.03 ± 0.01:1.0:0.24 ± 0.02:0.02 ± 0.01:0.24 ± 0.03:0.65 ± 0.05:0.57 ± 0.05:0.36 ± 0.03 at an electron impact energy of 70 eV. The absolute ionization cross sections of the 2,4-pentadiynylidyne and 2,4-pentadiynyl radicals were estimated to be 8.6 ± 1.7 × 10-16 cm2 and 9.7 ± 1.9 × 10-16 cm2, respectively. Our data can be employed in future space missions to detect the C5H and C5H3 radicals - crucial reaction intermediates in the formation of polycyclic aromatic hydrocarbon molecules - in the atmospheres of hydrocarbon rich planets (Jupiter, Saturn, Uranus, Neptune, Pluto) and their moons (Titan) and also in combustion flames via mass spectrometry coupled with matrix interval arithmetic.

  5. New opportunities for future small civil turbine engines - Overviewing the GATE studies

    NASA Technical Reports Server (NTRS)

    Strack, W. C.

    1979-01-01

    This paper presents an overview of four independent studies that explore the opportunities for future General Aviation Turbine Engines (GATE) in the 150-1000 SHP class. Detroit Diesel Allison, Garrett/AiResearch, Teledyne CAE, and Williams Research participated along with several airframers. These studies forecasted the potential impact of advanced technology turbine engines in the post-1988 market, identified important aircraft and missions, desirable engine sizes, engine performance and cost goals. Parametric evaluations of various engine cycles, configurations, design features, and advanced technology elements defined baseline conceptual engines for each of the important missions identified by the market analysis. Both fixed-wing and helicopter aircraft, and turboshaft, turboprop, and turbofan engines were considered. All four companies predicted sizable performance gains (e.g., 20% SFC decrease), and three predicted large engine cost reductions of sufficient magnitude to challenge the reciprocating engine in the 300-500 SHP class. Key technology areas were recommended for NASA support in order to realize these improvements.

  6. 75 FR 2067 - Airworthiness Directives; Turbomeca S.A. Model Arriel 1B, 1D, and 1D1 Turboshaft Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-14

    ... to the specified products. That NPRM was published in the Federal Register on June 12, 2009 (74 FR... Regulatory Policies and Procedures (44 FR 11034, February 26, 1979); and 3. Will not have a significant... service. The ruptures have been determined to be originated at the pinion teeth root due to...

  7. Compressor Study to Meet Large Civil Tilt Rotor Engine Requirements

    NASA Technical Reports Server (NTRS)

    Veres, Joseph P.

    2009-01-01

    A vehicle concept study has been made to meet the requirements of the Large Civil Tilt Rotorcraft vehicle mission. A vehicle concept was determined, and a notional turboshaft engine system study was conducted. The engine study defined requirements for the major engine components, including the compressor. The compressor design-point goal was to deliver a pressure ratio of 31:1 at an inlet weight flow of 28.4 lbm/sec. To perform a conceptual design of two potential compressor configurations to meet the design requirement, a mean-line compressor flow analysis and design code were used. The first configuration is an eight-stage axial compressor. Some challenges of the all-axial compressor are the small blade spans of the rear-block stages being 0.28 in., resulting in the last-stage blade tip clearance-to-span ratio of 2.4%. The second configuration is a seven-stage axial compressor, with a centrifugal stage having a 0.28-in. impeller-exit blade span. The compressors conceptual designs helped estimate the flow path dimensions, rotor leading and trailing edge blade angles, flow conditions, and velocity triangles for each stage.

  8. Compressor Study to Meet Large Civil Tilt Rotor Engine Requirements

    NASA Technical Reports Server (NTRS)

    Veres, Joseph P.

    2009-01-01

    A vehicle concept study has been made to meet the requirements of the Large Civil Tilt Rotorcraft vehicle mission. A vehicle concept was determined, and a notional turboshaft engine system study was conducted. The engine study defined requirements for the major engine components, including the compressor. The compressor design-point goal was to deliver a pressure ratio of 31:1 at an inlet weight flow of 28.4 lbm/sec. To perform a conceptual design of two potential compressor configurations to meet the design requirement, a mean-line compressor flow analysis and design code were used. The first configuration is an eight-stage axial compressor. Some challenges of the all-axial compressor are the small blade spans of the rear-block stages being 0.28 in., resulting in the last-stage blade tip clearance-to-span ratio of 2.4 percent. The second configuration is a seven-stage axial compressor, with a centrifugal stage having a 0.28-in. impeller-exit blade span. The compressors conceptual designs helped estimate the flow path dimensions, rotor leading and trailing edge blade angles, flow conditions, and velocity triangles for each stage.

  9. Multi-variable control of the GE T700 engine using the LQG/LTR design methodology

    NASA Technical Reports Server (NTRS)

    Pfeil, W. H.; Athans, M.; Spang, H. A., III

    1986-01-01

    The design of scalar and multi-variable feedback control systems for the GET700 turboshaft engine coupled to a helicopter rotor system is examined. A series of linearized models are presented and analyzed. Robustness and performance specifications are posed in the frequency domain. The linear-quadratic-Gaussian with loop-transfer-recovery (LQG/LTR) methodology is used to obtain a sequence of three feedback designs. Even in the single-input/single-output case, comparison of the current control system with that derived from the LQG/LTR approach shows significant performance improvement. The multi-variable designs, evaluated using linear and nonlinear simulations, show even more potential for performance improvement.

  10. The Navy/NASA Engine Program (NNEP89): A user's manual

    NASA Technical Reports Server (NTRS)

    Plencner, Robert M.; Snyder, Christopher A.

    1991-01-01

    An engine simulation computer code called NNEP89 was written to perform 1-D steady state thermodynamic analysis of turbine engine cycles. By using a very flexible method of input, a set of standard components are connected at execution time to simulate almost any turbine engine configuration that the user could imagine. The code was used to simulate a wide range of engine cycles from turboshafts and turboprops to air turborockets and supersonic cruise variable cycle engines. Off design performance is calculated through the use of component performance maps. A chemical equilibrium model is incorporated to adequately predict chemical dissociation as well as model virtually any fuel. NNEP89 is written in standard FORTRAN77 with clear structured programming and extensive internal documentation. The standard FORTRAN77 programming allows it to be installed onto most mainframe computers and workstations without modification. The NNEP89 code was derived from the Navy/NASA Engine program (NNEP). NNEP89 provides many improvements and enhancements to the original NNEP code and incorporates features which make it easier to use for the novice user. This is a comprehensive user's guide for the NNEP89 code.

  11. Analytical and numerical prediction of harmonic sound power in the inlet of aero-engines with emphasis on transonic rotation speeds

    NASA Astrophysics Data System (ADS)

    Lewy, Serge; Polacsek, Cyril; Barrier, Raphael

    2014-12-01

    Tone noise radiated through the inlet of a turbofan is mainly due to rotor-stator interactions at subsonic regimes (approach flight), and to the shock waves attached to each blade at supersonic helical tip speeds (takeoff). The axial compressor of a helicopter turboshaft engine is transonic as well and can be studied like turbofans at takeoff. The objective of the paper is to predict the sound power at the inlet radiating into the free field, with a focus on transonic conditions because sound levels are much higher. Direct numerical computation of tone acoustic power is based on a RANS (Reynolds averaged Navier-Stokes) solver followed by an integration of acoustic intensity over specified inlet cross-sections, derived from Cantrell and Hart equations (valid in irrotational flows). In transonic regimes, sound power decreases along the intake because of nonlinear propagation, which must be discriminated from numerical dissipation. This is one of the reasons why an analytical approach is also suggested. It is based on three steps: (i) appraisal of the initial pressure jump of the shock waves; (ii) 2D nonlinear propagation model of Morfey and Fisher; (iii) calculation of the sound power of the 3D ducted acoustic field. In this model, all the blades are assumed to be identical such that only the blade passing frequency and its harmonics are predicted (like in the present numerical simulations). However, transfer from blade passing frequency to multiple pure tones can be evaluated in a fourth step through a statistical analysis of irregularities between blades. Interest of the analytical method is to provide a good estimate of nonlinear acoustic propagation in the upstream duct while being easy and fast to compute. The various methods are applied to two turbofan models, respectively in approach (subsonic) and takeoff (transonic) conditions, and to a Turbomeca turboshaft engine (transonic case). The analytical method in transonic appears to be quite reliable by comparison

  12. Sensor Fault Detection and Diagnosis Simulation of a Helicopter Engine in an Intelligent Control Framework

    NASA Technical Reports Server (NTRS)

    Litt, Jonathan; Kurtkaya, Mehmet; Duyar, Ahmet

    1994-01-01

    This paper presents an application of a fault detection and diagnosis scheme for the sensor faults of a helicopter engine. The scheme utilizes a model-based approach with real time identification and hypothesis testing which can provide early detection, isolation, and diagnosis of failures. It is an integral part of a proposed intelligent control system with health monitoring capabilities. The intelligent control system will allow for accommodation of faults, reduce maintenance cost, and increase system availability. The scheme compares the measured outputs of the engine with the expected outputs of an engine whose sensor suite is functioning normally. If the differences between the real and expected outputs exceed threshold values, a fault is detected. The isolation of sensor failures is accomplished through a fault parameter isolation technique where parameters which model the faulty process are calculated on-line with a real-time multivariable parameter estimation algorithm. The fault parameters and their patterns can then be analyzed for diagnostic and accommodation purposes. The scheme is applied to the detection and diagnosis of sensor faults of a T700 turboshaft engine. Sensor failures are induced in a T700 nonlinear performance simulation and data obtained are used with the scheme to detect, isolate, and estimate the magnitude of the faults.

  13. Accurate ab initio structural parameters of the diatomic and triatomic van der Waals molecules (11)BNg (X(2)Π, A(2)Σ(+)) and (11)BNg2 (X̃(2)B1), Ng = (4)He, (20)Ne, (40)Ar, (84)Kr, and (132)Xe.

    PubMed

    Magoulas, Ilias; Papakondylis, Aristotle; Mavridis, Aristides

    2014-06-01

    The weakly interacting BNg and BNg2 molecular systems, Ng = He, Ne, Ar, Kr, and Xe, have been thoroughly studied through coupled-cluster RCCSD(T) calculations and large correlation consistent basis sets. For the BNg diatomics, the states examined are the X(2)Π and A(2)Σ(+), and the X̃(2)B1 state for the C2v BNg2 triatomics. A series of corrections render our final results reliable, judging as well from the (limited) experimental numbers available. Both BHe and BHe2 are marginally unbound, whereas the attractive interactions of the BNg X(2)Π states, where Ng = Ne, Ar, Kr, and Xe, are D0 = 19.8, 98.2, 141.9, and 209.1 cm(-1), respectively. For the BRn (Rn = radon) species, an estimated value of interaction energy D0 ≈ 280 cm(-1) is obtained by a D0 versus static polarizability (α) extrapolation. Corresponding atomization energies of the BNg2 (X̃(2)B1) molecules are AE0 = 52.0 (BNe2), 263.4 (BAr2), 384.6 (BKr2), and 576.9 (BXe2) cm(-1). PMID:24806885

  14. Experimental study on engine gas-path component fault monitoring using exhaust gas electrostatic signal

    NASA Astrophysics Data System (ADS)

    Sun, Jianzhong; Zuo, Hongfu; Liu, Pengpeng; Wen, Zhenhua

    2013-12-01

    This paper presents the recent development in engine gas-path components health monitoring using electrostatic sensors in combination with signal-processing techniques. Two ground-based engine electrostatic monitoring experiments are reported and the exhaust gas electrostatic monitoring signal-based fault-detection method is proposed. It is found that the water washing, oil leakage and combustor linear cracking result in an increase in the activity level of the electrostatic monitoring signal, which can be detected by the electrostatic monitoring system. For on-line health monitoring of the gas-path components, a baseline model-based fault-detection method is proposed and the multivariate state estimation technique is used to establish the baseline model for the electrostatic monitoring signal. The method is applied to a data set from a turbo-shaft engine electrostatic monitoring experiment. The results of the case study show that the system with the developed method is capable of detecting the gas-path component fault in an on-line fashion.

  15. Engine Power Turbine and Propulsion Pod Arrangement Study

    NASA Technical Reports Server (NTRS)

    Robuck, Mark; Zhang, Yiyi

    2014-01-01

    A study has been conducted for NASA Glenn Research Center under contract NNC10BA05B, Task NNC11TA80T to identify beneficial arrangements of the turboshaft engine, transmissions and related systems within the propulsion pod nacelle of NASA's Large Civil Tilt-Rotor 2nd iteration (LCTR2) vehicle. Propulsion pod layouts were used to investigate potential advantages, disadvantages, as well as constraints of various arrangements assuming front or aft shafted engines. Results from previous NASA LCTR2 propulsion system studies and tasks performed by Boeing under NASA contracts are used as the basis for this study. This configuration consists of two Fixed Geometry Variable Speed Power Turbine Engines and related drive and rotor systems (per nacelle) arranged in tilting nacelles near the wing tip. Entry-into-service (EIS) 2035 technology is assumed for both the engine and drive systems. The variable speed rotor system changes from 100 percent speed for hover to 54 percent speed for cruise by the means of a two speed gearbox concept developed under previous NASA contracts. Propulsion and drive system configurations that resulted in minimum vehicle gross weight were identified in previous work and used here. Results reported in this study illustrate that a forward shafted engine has a slight weight benefit over an aft shafted engine for the LCTR2 vehicle. Although the aft shafted engines provide a more controlled and centered CG (between hover and cruise), the length of the long rotor shaft and complicated engine exhaust arrangement outweighed the potential benefits. A Multi-Disciplinary Analysis and Optimization (MDAO) approach for transmission sizing was also explored for this study. This tool offers quick analysis of gear loads, bearing lives, efficiencies, etc., through use of commercially available RomaxDESIGNER software. The goal was to create quick methods to explore various concept models. The output results from RomaxDESIGNER have been successfully linked to Boeing

  16. Development and Application of A Membrane-Based Thermodenuder for Measurement of Volatile Particles Emitted by A Jet Turbine Engine

    SciTech Connect

    Cheng, Mengdawn

    2010-01-01

    Measurement of volatile particles emitted by modern jet engines is a daunting task. Besides the complexity in sampling jet aircraft exhaust, the main difficulty lies at how to faithfully capture the phase-partition dynamics of volatile particles as they travel downstream from the engine exhaust nozzle. As a result, the physico-chemical properties of the exhaust are also transformed. We have developed a sampling instrument that aims at enabling study of the phase-partition dynamics. The objective of this research project was to design and evaluate a new thermodenuder for performing phase separation of the engine-emitted volatile particles. The backbone of the new thermodenuder is a thin metallic membrane. The membrane enables extraction of molecules that can be thermally desorbed from the condensed particulate phases and collected for subsequent chemical analysis. Toward realization of the technique in the future field aircraft emissions measurement we tested this new thermo-denuding device using laboratory-generated particles that were made of non-volatile or semi-volatile chemicals. The particle penetration efficiency, a measure of the device performance, of this thermodenuder was found to be better than 99%. Results obtained from the tests executed at a number of operating temperature conditions show reasonably good thermal separation. We have scheduled to apply this new device to characterize emissions from a T63 turboshaft engine in the spring of 2010 and are expecting to show the engine results at the conference. The test results based on the laboratory-generated particles were encouraging for the intended application. With excellent particle transmission efficiency and an ability to simultaneously measure the composition in the gas and particle phases of the engine particles, we believe the new technology will make a great contribution to measurement research of engine emissions.

  17. Layered Systems Engineering Engines

    NASA Technical Reports Server (NTRS)

    Breidenthal, Julian C.; Overman, Marvin J.

    2009-01-01

    A notation is described for depicting the relationships between multiple, contemporaneous systems engineering efforts undertaken within a multi-layer system-of-systems hierarchy. We combined the concepts of remoteness of activity from the end customer, depiction of activity on a timeline, and data flow to create a new kind of diagram which we call a "Layered Vee Diagram." This notation is an advance over previous notations because it is able to be simultaneously precise about activity, level of granularity, product exchanges, and timing; these advances provide systems engineering managers a significantly improved ability to express and understand the relationships between many systems engineering efforts. Using the new notation, we obtain a key insight into the relationship between project duration and the strategy selected for chaining the systems engineering effort between layers, as well as insights into the costs, opportunities, and risks associated with alternate chaining strategies.

  18. Engineering and Software Engineering

    NASA Astrophysics Data System (ADS)

    Jackson, Michael

    The phrase ‘software engineering' has many meanings. One central meaning is the reliable development of dependable computer-based systems, especially those for critical applications. This is not a solved problem. Failures in software development have played a large part in many fatalities and in huge economic losses. While some of these failures may be attributable to programming errors in the narrowest sense—a program's failure to satisfy a given formal specification—there is good reason to think that most of them have other roots. These roots are located in the problem of software engineering rather than in the problem of program correctness. The famous 1968 conference was motivated by the belief that software development should be based on “the types of theoretical foundations and practical disciplines that are traditional in the established branches of engineering.” Yet after forty years of currency the phrase ‘software engineering' still denotes no more than a vague and largely unfulfilled aspiration. Two major causes of this disappointment are immediately clear. First, too many areas of software development are inadequately specialised, and consequently have not developed the repertoires of normal designs that are the indispensable basis of reliable engineering success. Second, the relationship between structural design and formal analytical techniques for software has rarely been one of fruitful synergy: too often it has defined a boundary between competing dogmas, at which mutual distrust and incomprehension deprive both sides of advantages that should be within their grasp. This paper discusses these causes and their effects. Whether the common practice of software development will eventually satisfy the broad aspiration of 1968 is hard to predict; but an understanding of past failure is surely a prerequisite of future success.

  19. Stirling engines

    SciTech Connect

    Reader, G.T.; Hooper

    1983-01-01

    The Stirling engine was invented by a Scottish clergyman in 1816, but fell into disuse with the coming of the diesel engine. Advances in materials science and the energy crisis have made a hot air engine economically attractive. Explanations are full and understandable. Includes coverage of the underlying thermodynamics and an interesting historical section. Topics include: Introduction to Stirling engine technology, Theoretical concepts--practical realities, Analysis, simulation and design, Practical aspects, Some alternative energy sources, Present research and development, Stirling engine literature.

  20. Neural Engineering

    NASA Astrophysics Data System (ADS)

    He, Bin

    About the Series: Bioelectric Engineering presents state-of-the-art discussions on modern biomedical engineering with respect to applications of electrical engineering and information technology in biomedicine. This focus affirms Springer's commitment to publishing important reviews of the broadest interest to biomedical engineers, bioengineers, and their colleagues in affiliated disciplines. Recent volumes have covered modeling and imaging of bioelectric activity, neural engineering, biosignal processing, bionanotechnology, among other topics.

  1. Thinking Engineering

    ERIC Educational Resources Information Center

    Martin, Stu; Sharp, Janet; Zachary, Loren

    2004-01-01

    Most people think that engineering and mathematics go hand in hand. To many, being an engineer means manipulating equations and calculating measurements to design and build structures of all kinds. And they are right. Engineering does involve a great deal of mathematics. But, building structures to withstand certain environmental conditions or…

  2. Stirling engines

    SciTech Connect

    Walker, G.

    1980-01-01

    Stirling engines exist in a bewildering array of mechanical arrangements. This book attempts to describe and classify the systems in a rational way, to explain the intricacies of the cycle, and to present a large amount of detailed information related to Stirling engines such as design, heat exchangers, working fluids, operation and performance, control equipment, recently developed engines, and current and proposed uses. (LCL)

  3. Engine Lubricant

    NASA Technical Reports Server (NTRS)

    1993-01-01

    PS 212, a plasma-sprayed coating developed by NASA, is used to coat valves in a new rotorcam engine. The coating eliminates the need for a liquid lubricant in the rotorcam, which has no crankshaft, flywheel, distributor or water pump. Developed by Murray United Development Corporation, it is a rotary engine only 10 inches long with four cylinders radiating outward from a central axle. Company officials say the engine will be lighter, more compact and cheaper to manufacture than current engines and will feature cleaner exhaust emissions. A licensing arrangement with a manufacturer is under negotiation. Primary applications are for automobiles, but the engine may also be used in light aircraft.

  4. Shockwave Engine: Wave Disk Engine

    SciTech Connect

    2010-01-14

    Broad Funding Opportunity Announcement Project: MSU is developing a new engine for use in hybrid automobiles that could significantly reduce fuel waste and improve engine efficiency. In a traditional internal combustion engine, air and fuel are ignited, creating high-temperature and high-pressure gases which expand rapidly. This expansion of gases forces the engine’s pistons to pump and powers the car. MSU’s engine has no pistons. It uses the combustion of air and fuel to build up pressure within the engine, generating a shockwave that blasts hot gas exhaust into the blades of the engine’s rotors causing them to turn, which generates electricity. MSU’s redesigned engine would be the size of a cooking pot and contain fewer moving parts—reducing the weight of the engine by 30%. It would also enable a vehicle that could use 60% of its fuel for propulsion.

  5. Saturn Engines

    NASA Technical Reports Server (NTRS)

    1969-01-01

    This set of photographs illustrates the different engines used on the Saturn IB and Saturn V launch vehicles developed by the Marshall Space Flight Center. The earlier Saturn IB utilized eight H-1 engines on its first stage, the S-IB (top left), while the first stage of the Saturn V, the S-IC, used five F-1 engines (top right). A single J-2 engine propelled the second stage of the Saturn IB's second stage, the S-IVB (bottom left), while five J-2 engines propelled the S-II (second) stage of the Saturn V (bottom right). A single J-2 engine also powered the S-IVB (third) stage (bottom left) of the Saturn V.

  6. Information engineering

    SciTech Connect

    Hunt, D.N.

    1997-02-01

    The Information Engineering thrust area develops information technology to support the programmatic needs of Lawrence Livermore National Laboratory`s Engineering Directorate. Progress in five programmatic areas are described in separate reports contained herein. These are entitled Three-dimensional Object Creation, Manipulation, and Transport, Zephyr:A Secure Internet-Based Process to Streamline Engineering Procurements, Subcarrier Multiplexing: Optical Network Demonstrations, Parallel Optical Interconnect Technology Demonstration, and Intelligent Automation Architecture.

  7. Wave cycle design for wave rotor engines with limited nitrogen oxide emissions

    NASA Astrophysics Data System (ADS)

    Nalim, Mohamed Razi

    1994-05-01

    Direct work exchange between gases in wave rotors can be used to create topping cycles for gas turbine engines with peak temperatures and pressures exceeding the limits that restrict the performance of present day turbomachinery. Analytical methods are used for preliminary design and evaluation of a class of wave rotor cycles that involve large-amplitude nonsteady expansions of hot combustion products in the wave channels. A computer code is then employed to calculate the detailed time-evolution of the channel flow field. It uses the method of characteristics for one-dimensional inviscid flow, extended to treat strong shocks, entropy gradients and discontinuities, and their interactions. Several wave rotor engine cycles are designed suitable for supersonic aircraft propulsion at Mach 2.6. One is a five-port topping cycle with wave expansion provided to accommodate both the temperature limit imposed by a low-NO(x) combustor, and the limit for cooled turbine blades. Performance improvement equivalent to a 50-150 K increase in turbine inlet temperature is obtained, for turboshaft core engines. Reverse-flow expansion of the hot gas is found to be superior for this cycle. A second type of cycle involves staged rich-lean combustion with expansion-wave cooling of very hot primary rich (phi approximately equal to 1.2-1.5) combustion products to a temperature (below 2000 K) permitting NO(x) reduction through hydrocarbon addition when necessary. Combustion is completed by rapid mixing of secondary air, similar to the two-stage rich-quench-lean (RQL) low-NO(x) combustor being evaluated at NASA Lewis for high speed propulsion, but at a lower temperature. This cycle provides an equivalent turbine-inlet-temperature improvement of about 250 K, while reducing peak temperature in the critical mixing zone by 250-400 K, compared to an equally efficient conventional cycle with RQL combustion. A through-flow expansion wave cycle is presented for this scheme. Both types of engine cycles

  8. Engineering Administration.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    This book is intended to acquaint naval engineering officers with their duties in the engineering department. Standard shipboard organizations are analyzed in connection with personnel assignments, division operations, and watch systems. Detailed descriptions are included for the administration of directives, ship's bills, damage control, training…

  9. Women Engineer.

    ERIC Educational Resources Information Center

    Neustadtl, Sara Jane

    This booklet is designed to provide information to girls about the nature of and possible career opportunities in engineering. Following a brief introduction in which the characteristics of engineers are outlined (such as ability to solve problems, interest in science/mathematics, and urge to make creative use of their intelligence), answers to…

  10. Electrochemical Engineering.

    ERIC Educational Resources Information Center

    Alkire, Richard C.

    1983-01-01

    Discusses engineering ramifications of electrochemistry, focusing on current/potential distribution, evaluation of trade-offs between influences of different phenomena, use of dimensionless numbers to assist in scale-over to new operating conditions, and economics. Also provides examples of electrochemical engineering education content related to…

  11. Systems Engineering

    NASA Technical Reports Server (NTRS)

    Pellerano, Fernando

    2015-01-01

    This short course provides information on what systems engineering is and how the systems engineer guides requirements, interfaces with the discipline leads, and resolves technical issues. There are many system-wide issues that either impact or are impacted by the thermal subsystem. This course will introduce these issues and illustrate them with real life examples.

  12. Holistic Engineering

    ERIC Educational Resources Information Center

    Grasso, Domenico; Martinelli, David

    2007-01-01

    In this article, the authors discuss how to prepare high-quality engineers who are better equipped to serve in the changing global marketplace, and suggest educators in pursuing the holistic concept of the "unity of knowledge" that will yield a definition of engineering more fitting for the times ahead. The unity of knowledge is fundamentally…

  13. Corrosion Engineering.

    ERIC Educational Resources Information Center

    White, Charles V.

    A description is provided for a Corrosion and Corrosion Control course offered in the Continuing Engineering Education Program at the General Motors Institute (GMI). GMI is a small cooperative engineering school of approximately 2,000 students who alternate between six-week periods of academic study and six weeks of related work experience in…

  14. Genetic Engineering

    ERIC Educational Resources Information Center

    Phillips, John

    1973-01-01

    Presents a review of genetic engineering, in which the genotypes of plants and animals (including human genotypes) may be manipulated for the benefit of the human species. Discusses associated problems and solutions and provides an extensive bibliography of literature relating to genetic engineering. (JR)

  15. Engine Coatings

    NASA Technical Reports Server (NTRS)

    1992-01-01

    Increasing the operating temperature of turbine engines reduces fuel consumption and increases engine efficiency. However, engine components must be protected from excessive heat. Lewis Research Center has successfully developed thermal barrier coatings (TBCs), which are deposited on the components. They insulate, offer oxidation and corrosion resistance and increase adherence. Surface temperatures can be reduced by 200 degrees centigrade or more. G. E. Aircraft Engines, a Lewis contractor, now uses a TBC based on the one developed at Lewis, on production engines. The system, which consists of a bond and a top coat extends component life from 1.3 to 2 times. The company is also testing TBCs on components that operate at higher temperatures.

  16. Overview of Engineering Design and Analysis at the NASA John C. Stennis Space Center

    NASA Technical Reports Server (NTRS)

    Ryan, Harry; Congiardo, Jared; Junell, Justin; Kirkpatrick, Richard

    2007-01-01

    A wide range of rocket propulsion test work occurs at the NASA John C. Stennis Space Center (SSC) including full-scale engine test activities at test facilities A-1, A-2, B-1 and B-2 as well as combustion device research and development activities at the E-Complex (E-1, E-2, E-3 and E-4) test facilities. The propulsion test engineer at NASA SSC faces many challenges associated with designing and operating a test facility due to the extreme operating conditions (e.g., cryogenic temperatures, high pressures) of the various system components and the uniqueness of many of the components and systems. The purpose of this paper is to briefly describe the NASA SSC Engineering Science Directorate s design and analysis processes, experience, and modeling techniques that are used to design and support the operation of unique rocket propulsion test facilities.

  17. Engineering Geology

    ERIC Educational Resources Information Center

    Lee, Fitzhugh T.

    1974-01-01

    Briefly reviews the increasing application of geologic principles, techniques and data to engineering practices in the areas of land use and zoning controls, resource management energy programs and other fields. (BR)

  18. Engine technology

    NASA Technical Reports Server (NTRS)

    Hoffman, A. C.

    1982-01-01

    Materials used in a presentation on development of engine technology for electric flight systems are presented. Component and system technology issues, NASA's role, and flight test requirements are outlined.

  19. Harmonic engine

    DOEpatents

    Bennett, Charles L.

    2009-10-20

    A high efficiency harmonic engine based on a resonantly reciprocating piston expander that extracts work from heat and pressurizes working fluid in a reciprocating piston compressor. The engine preferably includes harmonic oscillator valves capable of oscillating at a resonant frequency for controlling the flow of working fluid into and out of the expander, and also preferably includes a shunt line connecting an expansion chamber of the expander to a buffer chamber of the expander for minimizing pressure variations in the fluidic circuit of the engine. The engine is especially designed to operate with very high temperature input to the expander and very low temperature input to the compressor, to produce very high thermal conversion efficiency.

  20. The Potential of the Ag 2B- 1 1Π uState

    NASA Astrophysics Data System (ADS)

    Müschenborn, H.-J.

    1996-09-01

    The potential of the B- 1 1Π ustate of the Ag 2molecule is presented. The isotopically selective measurements of V. Beutel, M. Kuhn, and W. Demtröder ( J. Mol. Spectrosc.155,343, 1992) were analyzed individually for each isotope and compared with each other. Morse and RKR potentials modeled the experimental data with a standard deviation of 0.1 and 0.2 cm -1, respectively. Their deficiencies are of a completely different nature: the Morse potential describes the vibrational progression very well, but fails for the rotational part, while the RKR potential models the latter better and results in large errors at the top vibrational levels. Both were taken as initial potentials for the IPA procedure. The final potential reproduces all measured term values of all isotopomers with a standard deviation of 0.030 cm -1compared to an experimental accuracy of 0.04 cm -1. The detailed analysis demonstrates clearly the uniqueness and mass independence of the final rotationless IPA potential energy curve. Its accuracy can be estimated to be ±2 cm -1within the area covered by the turning points of the RKR potential and ±0.5 cm -1around the potential minimum at re= 2.623 Å. Since the experimental data base covers only about 12% of the full potential well, the estimation of the dissociation energy may contain significant errors. Extrapolating the final potential for larger internuclear distances by a Morse function, we estimate the dissociation energy to be De= 8203 ± 10 cm -1.

  1. SODIUM CHANNELS (NAV1.2/B1) EXPRESSED IN XENOPUS OOCYTES DEMONSTRATE SENSITIVITY TO PYRETHROIDS.

    EPA Science Inventory

    Voltage-sensitive sodium channels (VSSCs) are hypothesized to be a primary target of pyrethroid insecticides. However, multiple isoforms of VSSCs exist and the sensitivity of different isoforms to pyrethroids has not been well characterized. The Nav1.2/1 channel predominates in a...

  2. Software engineering

    NASA Technical Reports Server (NTRS)

    Fridge, Ernest M., III; Hiott, Jim; Golej, Jim; Plumb, Allan

    1993-01-01

    Today's software systems generally use obsolete technology, are not integrated properly with other software systems, and are difficult and costly to maintain. The discipline of reverse engineering is becoming prominent as organizations try to move their systems up to more modern and maintainable technology in a cost effective manner. The Johnson Space Center (JSC) created a significant set of tools to develop and maintain FORTRAN and C code during development of the space shuttle. This tool set forms the basis for an integrated environment to reengineer existing code into modern software engineering structures which are then easier and less costly to maintain and which allow a fairly straightforward translation into other target languages. The environment will support these structures and practices even in areas where the language definition and compilers do not enforce good software engineering. The knowledge and data captured using the reverse engineering tools is passed to standard forward engineering tools to redesign or perform major upgrades to software systems in a much more cost effective manner than using older technologies. The latest release of the environment was in Feb. 1992.

  3. Engineering Geology

    ERIC Educational Resources Information Center

    Hatheway, Allen W.

    1978-01-01

    Engineering geology remains a potpourri of applied classical geology, and 1977 witnessed an upswing in demand for these services. Traditional foundation-related work was slight, but construction related to national needs increased briskly. Major cities turned to concerns of transit waste-water treatment and solid-waste disposal. (Author/MA)

  4. Thermal engine

    SciTech Connect

    Karnes, T.E.; Trupin, R.J.

    1984-01-03

    A thermal engine utilizing a strip of nitinol material or other thermally responsive shape memory effect material to drive a reciprocating output shaft, said strip of material forming a common wall between two different alternating temperature sources which thermally cycle the material.

  5. Adaptive Engineering

    ERIC Educational Resources Information Center

    VanderSteen, Jonathan

    2011-01-01

    Engineers today cannot meet their professional obligation to the welfare of society if they do not have a broad, multidisciplinary vision, and yet a multidisciplinary vision is becoming enormously difficult to obtain. A new curriculum must emerge that can integrate a focused, discipline-based scientific approach with an integrated approach. To do…

  6. Photoreceptor engineering

    PubMed Central

    Ziegler, Thea; Möglich, Andreas

    2015-01-01

    Sensory photoreceptors not only control diverse adaptive responses in Nature, but as light-regulated actuators they also provide the foundation for optogenetics, the non-invasive and spatiotemporally precise manipulation of cellular events by light. Novel photoreceptors have been engineered that establish control by light over manifold biological processes previously inaccessible to optogenetic intervention. Recently, photoreceptor engineering has witnessed a rapid development, and light-regulated actuators for the perturbation of a plethora of cellular events are now available. Here, we review fundamental principles of photoreceptors and light-regulated allostery. Photoreceptors dichotomize into associating receptors that alter their oligomeric state as part of light-regulated allostery and non-associating receptors that do not. A survey of engineered photoreceptors pinpoints light-regulated association reactions and order-disorder transitions as particularly powerful and versatile design principles. Photochromic photoreceptors that are bidirectionally toggled by two light colors augur enhanced spatiotemporal resolution and use as photoactivatable fluorophores. By identifying desirable traits in engineered photoreceptors, we provide pointers for the design of future, light-regulated actuators. PMID:26137467

  7. Concurrent engineering

    NASA Technical Reports Server (NTRS)

    Chamis, C. C.; Leger, L.; Hunter, D.; Jones, C.; Sprague, R.; Berke, L.; Newell, J.; Singhal, S.

    1991-01-01

    The following subject areas are covered: issues (liquid rocket propulsion - current development approach, current certification process, and costs of engineering changes); state of the art (DICE information management system, key government participants, project development strategy, quality management, and numerical propulsion system simulation); needs identified; and proposed program.

  8. Harmonic engine

    DOEpatents

    Bennett, Charles L.; Sewall, Noel; Boroa, Carl

    2014-08-19

    An engine based on a reciprocating piston engine that extracts work from pressurized working fluid. The engine includes a harmonic oscillator inlet valve capable of oscillating at a resonant frequency for controlling the flow of working fluid into of the engine. In particular, the inlet valve includes an inlet valve head and a spring arranged together as a harmonic oscillator so that the inlet valve head is moveable from an unbiased equilibrium position to a biased closed position occluding an inlet. Upon releasing the inlet valve the inlet valve head undergoes a single oscillation past the equilibrium positio to a maximum open position and returns to a biased return position close to the closed position to choke the flow and produce a pressure drop across the inlet valve causing the inlet valve to close. Protrusions carried either by the inlet valve head or piston head are used to bump open the inlet valve from the closed position and initiate the single oscillation of the inlet valve head, and protrusions carried either by the outlet valve head or piston head are used to close the outlet valve ahead of the bump opening of the inlet valve.

  9. Engineering seismology

    USGS Publications Warehouse

    N.N, Ambraseys

    1991-01-01

    Twenty years have elasped since the first issue of Earthquakes & Volcanoes. Apart from the remarkable increases in the number of scientists actively enagaged in earth sciences, what are the outstanding achievements during the past 20 years in the field of engineering seismology, which is my own speciality?

  10. Software engineering as an engineering discipline

    NASA Technical Reports Server (NTRS)

    Berard, Edward V.

    1988-01-01

    The following topics are discussed in the context of software engineering: early use of the term; the 1968 NATO conference; Barry Boehm's definition; four requirements fo software engineering; and additional criteria for software engineering. Additionally, the four major requirements for software engineering--computer science, mathematics, engineering disciplines, and excellent communication skills--are discussed. The presentation is given in vugraph form.

  11. Enhancing Engineering Education through Engineering Management

    ERIC Educational Resources Information Center

    Pence, Kenneth R.; Rowe, Christopher J.

    2012-01-01

    Engineering Management courses are added to a traditional engineering curriculum to enhance the value of an undergraduate's engineering degree. A four-year engineering degree often leaves graduates lacking in business and management acumen. Engineering management education covers topics enhancing the value of new graduates by teaching management…

  12. Re-engineering Engineering Education

    ERIC Educational Resources Information Center

    Gordon, Bernard M.; Silevitch, Michael B.

    2009-01-01

    In 2005, leaders gathered by the National Association of Manufacturers declared yet another "STEM" emergency. In the face of global competition, they argued, the number of bachelor's degrees awarded annually to U.S. students in science, math and engineering must double by 2015. In fact, the need for STEM talent is even more critical today as the…

  13. Engineering Review Information System

    NASA Technical Reports Server (NTRS)

    Grems, III, Edward G. (Inventor); Henze, James E. (Inventor); Bixby, Jonathan A. (Inventor); Roberts, Mark (Inventor); Mann, Thomas (Inventor)

    2015-01-01

    A disciplinal engineering review computer information system and method by defining a database of disciplinal engineering review process entities for an enterprise engineering program, opening a computer supported engineering item based upon the defined disciplinal engineering review process entities, managing a review of the opened engineering item according to the defined disciplinal engineering review process entities, and closing the opened engineering item according to the opened engineering item review.

  14. Exoskeletal Engine

    NASA Technical Reports Server (NTRS)

    Chamis, Christos C. (Inventor); Blankson, Isaiah M. (Inventor); Richter, William A. (Inventor)

    2002-01-01

    A turbojet engine is made from a drum-like portion having a circular blade section extending inwardly therefrom, a support member, and a bearing arranged around a circle having a diameter substantially equal to or greater than the diameter of the blade section. The drum-like portion is rotatably mounted within the support member on the bearing. Instead of a turbine spinning on a shaft, a turbine spinning within a drum is employed.

  15. Heat engines

    NASA Astrophysics Data System (ADS)

    Rekos, N. F., Jr.; Parsons, E. L., Jr.

    1989-09-01

    For the past decade, the Department of Energy (DOE) has sponsored projects to develop diesel and gas turbine engines capable of operating on low-cost, coal-based fuels. Much of the current work addresses the use of coal-water fuel (CWF) in diesel and turbines, although there is some work with dry coal feed and other coal fuels. Both the diesel and gas turbine portions of the program include proof-of-concept and support projects. Specific highlights of the program include: engine tests and economic analyses have shown that CWF can replace 70 percent of the diesel oil used in the duty cycle of a typical main-line locomotive; A. D. Little and Cooper-Bessemer completed a system and economic study of coal-fueled diesel engines for modular power and industrial cogeneration markets. The coal-fueled diesel was found to be competitive at fuel oil prices of $5.50 per million British thermal units (MBtu); Over 200 hours of testing have been completed using CWF in full-scale, single-cylinder diesel engines. Combustion efficiencies have exceeded 99 percent; Both CWF and dry coal fuel forms can be burned in short residence time in-line combustors and in off-base combustors with a combustion efficiency of over 99 percent; Rich/lean combustion systems employed by the three major DOE contractors have demonstrated low NO(sub x) emissions levels; Contractors have also achieved promising results for controlling sulfur oxide (SO(sub x)) emissions using calcium-based sorbents; Slagging combustors have achieved between 65 and 95 percent slag capture, which will limit particulate loading on pre-turbine cleanup devices. For many of the gas turbine and diesel applications emission standards do not exist. Our goal is to develop coal-fueled diesels and gas turbines that not only meet all applicable emission standards that do exist, but also are capable of meeting possible future standards.

  16. Web Engineering

    SciTech Connect

    White, Bebo

    2003-06-23

    Web Engineering is the application of systematic, disciplined and quantifiable approaches to development, operation, and maintenance of Web-based applications. It is both a pro-active approach and a growing collection of theoretical and empirical research in Web application development. This paper gives an overview of Web Engineering by addressing the questions: (a) why is it needed? (b) what is its domain of operation? (c) how does it help and what should it do to improve Web application development? and (d) how should it be incorporated in education and training? The paper discusses the significant differences that exist between Web applications and conventional software, the taxonomy of Web applications, the progress made so far and the research issues and experience of creating a specialization at the master's level. The paper reaches a conclusion that Web Engineering at this stage is a moving target since Web technologies are constantly evolving, making new types of applications possible, which in turn may require innovations in how they are built, deployed and maintained.

  17. Engineering Liver

    PubMed Central

    Griffith, Linda G.; Wells, Alan; Stolz, Donna Beer

    2014-01-01

    Interest in “engineering liver” arises from multiple communities: therapeutic replacement; mechanistic models of human processes; and drug safety and efficacy studies. An explosion of micro- and nano-fabrication, biomaterials, microfluidic, and other technologies potentially afford unprecedented opportunity to create microphysiological models of human liver, but engineering design principles for how to deploy these tools effectively towards specific applications, including how to define the essential constraints of any given application (including available sources of cells, acceptable cost, and user-friendliness) are still emerging. Arguably less appreciated is the parallel growth in computational systems biology approaches towards these same problems – particularly, in parsing complex disease processes from clinical material, building models of response networks, and in how to interpret the growing compendium of data on drug efficacy and toxicology in patient populations. Here, we provide insight into how the complementary paths of “engineering liver” – experimental and computational – are beginning to interplay towards greater illumination of human disease states and technologies for drug development. PMID:24668880

  18. Planetary engineering

    NASA Astrophysics Data System (ADS)

    Pollack, James B.; Sagan, Carl

    Assuming commercial fusion power, heavy lift vehicles and major advances in genetic engineering, the authors survey possible late-21st century methods of working major transformations in planetary environments. Much more Earthlike climates may be produced on Mars by generating low freezing point greenhouse gases from indigenous materials; on Venus by biological conversion of CO2 to graphite, by canceling the greenhouse effect with high-altitude absorbing fine particles, or by a sunshield at the first Lagrangian point; and on Titan by greenhouses and/or fusion warming. However, in our present state of ignorance we cannot guarantee a stable endstate or exclude unanticipated climatic feedbacks or other unintended consequences. Moreover, as the authors illustrate by several examples, many conceivable modes of planetary engineering are so wasteful of scarce solar system resources and so destructive of important scientific information as to raise profound ethical issues, even if they were economically feasible, which they are not. Global warming on Earth may lead to calls for mitigation by planetary engineering, e.g., emplacement and replenishment of anti-greenhouse layers at high altitudes, or sunshields in space. But here especially we must be concerned about precision, stability, and inadvertent side-effects. The safest and most cost-effective means of countering global warming - beyond, e.g., improved energy efficiency, CFC bans and alternative energy sources - is the continuing reforestation of approximately 2 times 107 sq km of the Earth's surface. This can be accomplished with present technology and probably at the least cost.

  19. Planetary engineering

    NASA Technical Reports Server (NTRS)

    Pollack, James B.; Sagan, Carl

    1991-01-01

    Assuming commercial fusion power, heavy lift vehicles and major advances in genetic engineering, the authors survey possible late-21st century methods of working major transformations in planetary environments. Much more Earthlike climates may be produced on Mars by generating low freezing point greenhouse gases from indigenous materials; on Venus by biological conversion of CO2 to graphite, by canceling the greenhouse effect with high-altitude absorbing fine particles, or by a sunshield at the first Lagrangian point; and on Titan by greenhouses and/or fusion warming. However, in our present state of ignorance we cannot guarantee a stable endstate or exclude unanticipated climatic feedbacks or other unintended consequences. Moreover, as the authors illustrate by several examples, many conceivable modes of planetary engineering are so wasteful of scarce solar system resources and so destructive of important scientific information as to raise profound ethical issues, even if they were economically feasible, which they are not. Global warming on Earth may lead to calls for mitigation by planetary engineering, e.g., emplacement and replenishment of anti-greenhouse layers at high altitudes, or sunshields in space. But here especially we must be concerned about precision, stability, and inadvertent side-effects. The safest and most cost-effective means of countering global warming - beyond, e.g., improved energy efficiency, CFC bans and alternative energy sources - is the continuing reforestation of approximately 2 times 107 sq km of the Earth's surface. This can be accomplished with present technology and probably at the least cost.

  20. Engineering organs.

    PubMed

    Atala, Anthony

    2009-10-01

    Applications of regenerative medicine technology may offer novel therapies for patients with injuries, end-stage organ failure, or other clinical problems. Currently, patients suffering from diseased and injured organs can be treated with transplanted organs. However, there is a severe shortage of donor organs that is worsening yearly as the population ages and new cases of organ failure increase. Scientists in the field of regenerative medicine and tissue engineering are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. The stem cell field is also advancing rapidly, opening new avenues for this type of therapy. For example, therapeutic cloning and cellular reprogramming may one day provide a potentially limitless source of cells for tissue engineering applications. Although stem cells are still in the research phase, some therapies arising from tissue engineering endeavors have already entered the clinical setting successfully, indicating the promise regenerative medicine holds for the future. PMID:19896823

  1. Biocommodity Engineering.

    PubMed

    Lynd; Wyman; Gerngross

    1999-10-01

    The application of biotechnology to the production of commodity products (fuels, chemicals, and materials) offering benefits in terms of sustainable resource supply and environmental quality is an emergent area of intellectual endeavor and industrial practice with great promise. Such "biocommodity engineering" is distinct from biotechnology motivated by health care at multiple levels, including economic driving forces, the importance of feedstocks and cost-motivated process engineering, and the scale of application. Plant biomass represents both the dominant foreseeable source of feedstocks for biotechnological processes as well as the only foreseeable sustainable source of organic fuels, chemicals, and materials. A variety of forms of biomass, notably many cellulosic feedstocks, are potentially available at a large scale and are cost-competitive with low-cost petroleum whether considered on a mass or energy basis, and in terms of price defined on a purchase or net basis for both current and projected mature technology, and on a transfer basis for mature technology. Thus the central, and we believe surmountable, impediment to more widespread application of biocommodity engineering is the general absence of low-cost processing technology. Technological and research challenges associated with converting plant biomass into commodity products are considered relative to overcoming the recalcitrance of cellulosic biomass (converting cellulosic biomass into reactive intermediates) and product diversification (converting reactive intermediates into useful products). Advances are needed in pretreatment technology to make cellulosic materials accessible to enzymatic hydrolysis, with increased attention to the fundamental chemistry operative in pretreatment processes likely to accelerate progress. Important biotechnological challenges related to the utilization of cellulosic biomass include developing cellulase enzymes and microorganisms to produce them, fermentation of

  2. Turboelectric Distributed Propulsion Engine Cycle Analysis for Hybrid-Wing-Body Aircraft

    NASA Technical Reports Server (NTRS)

    Felder, James L.; Kim, Hyun Dae; Brown, Gerald V.

    2009-01-01

    possibilities. The Boeing N2 hybrid-wing-body (HWB) is used as a baseline aircraft for this study. The two pylon mounted conventional turbofans are replaced by two wing-tip mounted turboshaft engines, each driving a superconducting generator. Both generators feed a common electrical bus which distributes power to an array of superconducting motor-driven fans in a continuous nacelle centered along the trailing edge of the upper surface of the wing-body. A key finding was that traditional inlet performance methodology has to be modified when most of the air entering the inlet is boundary layer air. A very thorough and detailed propulsion/airframe integration (PAI) analysis is required at the very beginning of the design process since embedded engine inlet performance must be based on conditions at the inlet lip rather than freestream conditions. Examination of a range of fan pressure ratios yielded a minimum Thrust-specific-fuel-consumption (TSFC) at the aerodynamic design point of the vehicle (31,000 ft /Mach 0.8) between 1.3 and 1.35 FPR. We deduced that this was due to the higher pressure losses prior to the fan inlet as well as higher losses in the 2-D inlets and nozzles. This FPR is likely to be higher than the FPR that yields a minimum TSFC in a pylon mounted engine. 1

  3. Engineering Lessons Learned and Systems Engineering Applications

    NASA Technical Reports Server (NTRS)

    Gill, Paul S.; Garcia, Danny; Vaughan, William W.

    2005-01-01

    Systems Engineering is fundamental to good engineering, which in turn depends on the integration and application of engineering lessons learned. Thus, good Systems Engineering also depends on systems engineering lessons learned from within the aerospace industry being documented and applied. About ten percent of the engineering lessons learned documented in the NASA Lessons Learned Information System are directly related to Systems Engineering. A key issue associated with lessons learned datasets is the communication and incorporation of this information into engineering processes. As part of the NASA Technical Standards Program activities, engineering lessons learned datasets have been identified from a number of sources. These are being searched and screened for those having a relation to Technical Standards. This paper will address some of these Systems Engineering Lessons Learned and how they are being related to Technical Standards within the NASA Technical Standards Program, including linking to the Agency's Interactive Engineering Discipline Training Courses and the life cycle for a flight vehicle development program.

  4. Stirling engine

    SciTech Connect

    Bolger, S.R.

    1992-03-17

    This patent describes an engine. It comprises at least two variable volume compartments joined by a porous medium regenerator; heat exchangers in heat exchange relationships with the variable volume compartments; a fixed quantity of gas in the compartments; a piston in each of the compartments; means to control the pistons to vary the volumes of the gas transferring between the compartments in the form of overlapping quadrilateral waveforms to compress the gas in both compartments through the same cycle pressure ratio during a cycle compression step, to shift the gas between compartments and to expand the gas in both compartments through the same cycle pressure ratio during a cycle expansion step.

  5. Engine construction

    SciTech Connect

    Dillon, C.L.

    1984-03-06

    An engine has at least two piston-cylinder assemblies each comprising a cylinder formed in an engine block with a cylinder head and a piston therein in sliding relationship toward and away from the head, a piston rod operatively connected to the piston and to a crankshaft, motion producing member of shape-memory material, e.g. Nitinol, having a transformation temperature range, secured to the cylinder head and the side of the piston opposite from the connecting rod, the motion producing member having a heat treated high temperature extended shape memory position and a low temperature low energy compressed position, the Nitinol member being of hollow tubular form and having pressure and return hoses connected thereto for supplying and removing cooling fluid into and from the Nitinol member, an electrical heating device connected to the Nitinol member, whereby the Nitinol member is easily compressed with relatively little force from the extended shape memory position to the compressed position when cooling fluid is supplied thereto to reduce the temperature of the Nitinol member to or below the lower limit of the transformation temperature range and the Nitinol member is automatically extended with relatively great force from the compressed position to the shape memory position when heated by the heating device to or above the upper limit of the transformation temperature range.

  6. Software engineering as an engineering discipline

    NASA Technical Reports Server (NTRS)

    Gibbs, Norman

    1988-01-01

    The goals of the Software Engineering Institute's Education Program are as follows: to increase the number of highly qualified software engineers--new software engineers and existing practitioners; and to be the leading center of expertise for software engineering education and training. A discussion of these goals is presented in vugraph form.

  7. Reciprocating engines

    NASA Technical Reports Server (NTRS)

    Akkerman, J. W. (Inventor)

    1981-01-01

    An intake valve arrangement for positively controlling the opening and closing of the poppet valve in a hot gas cylinder in a hydrazine powered engine is described. The poppet valve is operated by the piston and gas pressure only. The poppet valve uses a pneumatic spring which holds the poppet valve against the piston while the valve is opened and closed. To accomplish this, a poppet valve is slidably mounted in a pneumatic spring chamber which reaches a pressure approaching the gas supply pressure and, during the opening of the valve, the spring chamber retains enough pressure to hold the poppet valve onto the piston. In addition, the bottom of the poppet valve can have a suction cup type configuration to hold the poppet valve on the piston during the down stroke.

  8. How Engineers Engineer: Lessons from My First Big Engineering Project

    ERIC Educational Resources Information Center

    Roman, Harry T.

    2008-01-01

    Little did the author realize how much his first engineering project would change his career path, but when it came, he was hooked forever on doing R&D-type engineering. In this article, the author takes the reader back to his first really important electrical engineering project. While the technology he worked on back then is antiquated by…

  9. Stirling engine application study

    SciTech Connect

    Teagan, W.P.; Cunningham, D.R.

    1983-03-01

    The potential for Stirling engine applications in the 0.5 to 5000 hp output range is assessed. The following are included: a market survey of potential engine applications, classification of applications, conventional engine markets and performance characteristics, status of Sterling engine systems, selection of application classes for Stirling engines, and the possible effects of technology, economic conditions, and regulatory changes. (MHR)

  10. The Engineering Labor Market

    ERIC Educational Resources Information Center

    Ryoo, Jaewoo; Rosen, Sherwin

    2004-01-01

    This paper develops a dynamic supply and demand model of occupational choice and applies it to the engineering profession. The model is largely successful in understanding data in the U.S. engineering labor market. The engineering market responds strongly to economic forces. The demand for engineers responds to the price of engineering services…

  11. Industrial Education. "Small Engines".

    ERIC Educational Resources Information Center

    Parma City School District, OH.

    Part of a series of curriculum guides dealing with industrial education in junior high schools, this guide provides the student with information and manipulative experiences on small gasoline engines. Included are sections on shop adjustment, safety, small engines, internal combustion, engine construction, four stroke engines, two stroke engines,…

  12. Metabolic Engineering X Conference

    SciTech Connect

    Flach, Evan

    2015-05-07

    The International Metabolic Engineering Society (IMES) and the Society for Biological Engineering (SBE), both technological communities of the American Institute of Chemical Engineers (AIChE), hosted the Metabolic Engineering X Conference (ME-X) on June 15-19, 2014 at the Westin Bayshore in Vancouver, British Columbia. It attracted 395 metabolic engineers from academia, industry and government from around the globe.

  13. Engineering Allostery

    PubMed Central

    Raman, Srivatsan; Taylor, Noah; Genuth, Naomi; Fields, Stanley; Church, George M.

    2014-01-01

    Allosteric proteins have great potential in synthetic biology, but our limited understanding of the molecular underpinnings of allostery has hindered the development of designer molecules, including transcription factors with new DNA-binding or ligand-binding specificities that respond appropriately to inducers. Such allosteric proteins could function as novel switches in complex circuits, metabolite sensors, or orthogonal regulators for independent, inducible control of multiple genes. Advances in DNA synthesis and next-generation sequencing technologies have enabled the assessment of millions of mutants in a single experiment, providing new opportunities to study allostery. Using the classic LacI protein as an example, we describe a genetic selection system using a bidirectional reporter to capture mutants in both allosteric states, allowing the positions most critical for allostery to be identified. This approach is not limited to bacterial transcription factors, and could reveal new mechanistic insights and facilitate engineering of other major classes of allosteric proteins such as nuclear receptors, two-component systems, G-protein coupled receptors and protein kinases. PMID:25306102

  14. Genetically engineered foods

    MedlinePlus

    ... plants or animals) inserted into their genetic codes. Genetic engineering can be done with plants, animals, or bacteria ... have been genetically engineering plants since the 1990s. Genetic engineering allows scientists to speed this process up by ...

  15. Environmental Engineering in Mining Engineering Education

    ERIC Educational Resources Information Center

    Mahamud-Lopez, Manuel Maria; Menendez-Aguado, Juan Maria

    2005-01-01

    In this paper, the current profile of the environmental engineer and the programming of the subject "Environmental Engineering and Technology" corresponding to the studies of Mining Engineering at the University of Oviedo in Spain, is discussed. Professional profile, student knowledge prior to and following instruction as well as available…

  16. Engineering Encounters: Blasting off with Engineering

    ERIC Educational Resources Information Center

    Dare, Emily A.; Childs, Gregory T.; Cannaday, E. Ashley; Roehrig, Gillian H

    2014-01-01

    What better way to engage young students in physical science concepts than to have them engineer flying toy rockets? The integration of engineering into science classrooms is advocated by the "Next Generation Science Standards" (NGSS) and researchers alike (Brophy et al. 2008), as engineering provides: (1) A "real-world…

  17. Re-Engineering the Engineering Degree Course.

    ERIC Educational Resources Information Center

    Marsh, Rodney

    Students enrolled to degree programs in 1997 will become the first graduates of the 21st century. Engineering courses in the School of Engineering at Leeds Metropolitan University have changed immensely in the last two years, so as to support new markets. Disciplines such as industrial engineering, electronics and computing have enjoyed their…

  18. Software engineering as an engineering discipline

    NASA Technical Reports Server (NTRS)

    Freedman, Glenn B.

    1988-01-01

    The purpose of this panel is to explore the emerging field of software engineering from a variety of perspectives: university programs; industry training and definition; government development; and technology transfer. In doing this, the panel will address the issues of distinctions among software engineering, computer science, and computer hardware engineering as they relate to the challenges of large, complex systems.

  19. Space engine safety system

    NASA Technical Reports Server (NTRS)

    Maul, William A.; Meyer, Claudia M.

    1991-01-01

    A rocket engine safety system is designed to initiate control procedures which will minimize damage to the engine and vehicle or test stand in the event of an engine failure. This report describes the features and the implementation issues associated with rocket engine safety systems. Specific concerns of safety systems applied to a space-based engine and long duration space missions are discussed. Examples of safety system features and architectures are given from recent safety monitoring investigations conducted for the Space Shuttle Main Engine and for future liquid rocket engines. Also, a general design and implementation process for rocket engine safety systems is presented.

  20. Space engine safety system

    NASA Technical Reports Server (NTRS)

    Maul, William A.; Meyer, Claudia M.

    1991-01-01

    A rocket engine safety system was designed to initiate control procedures to minimize damage to the engine or vehicle or test stand in the event of an engine failure. The features and the implementation issues associated with rocket engine safety systems are discussed, as well as the specific concerns of safety systems applied to a space-based engine and long duration space missions. Examples of safety system features and architectures are given, based on recent safety monitoring investigations conducted for the Space Shuttle Main Engine and for future liquid rocket engines. Also, the general design and implementation process for rocket engine safety systems is presented.

  1. Using Collaborative Engineering to Inform Collaboration Engineering

    NASA Technical Reports Server (NTRS)

    Cooper, Lynne P.

    2012-01-01

    Collaboration is a critical competency for modern organizations as they struggle to compete in an increasingly complex, global environment. A large body of research on collaboration in the workplace focuses both on teams, investigating how groups use teamwork to perform their task work, and on the use of information systems to support team processes ("collaboration engineering"). This research essay presents collaboration from an engineering perspective ("collaborative engineering"). It uses examples from professional and student engineering teams to illustrate key differences in collaborative versus collaboration engineering and investigates how challenges in the former can inform opportunities for the latter.

  2. Alternative Automobile Engines

    ERIC Educational Resources Information Center

    Wilson, David Gordon

    1978-01-01

    Requirements for cleaner and more efficient engines have stimulated a search for alternatives to the conventional spark-ignition engine. So far, the defects of the alternative engines are clearer than the virtues. The following engines are compared: spark ignition, diesel, vapor-cycle, Stirling, and gas turbine. (Author/MA)

  3. The Stirling engine

    NASA Astrophysics Data System (ADS)

    This video describes the Stirling engine, an external combustion engine which creates heat energy to power the motor, and can use many types of fuel. It can be used for both stationary and propulsion purposes and has advantages of better fuel economy and cleaner exhaust than internal combustion engines. The engine is shown being road tested at Langley Air Force Base.

  4. Engineering Lessons Learned and Systems Engineering Applications

    NASA Technical Reports Server (NTRS)

    Gill, Paul S.; Garcia, Danny; Vaughan, William W.

    2005-01-01

    Systems Engineering is fundamental to good engineering, which in turn depends on the integration and application of engineering lessons learned and technical standards. Thus, good Systems Engineering also depends on systems engineering lessons learned from within the aerospace industry being documented and applied. About ten percent of the engineering lessons learned documented in the NASA Lessons Learned Information System are directly related to Systems Engineering. A key issue associated with lessons learned datasets is the communication and incorporation of this information into engineering processes. Systems Engineering has been defined (EINIS-632) as "an interdisciplinary approach encompassing the entire technical effort to evolve and verify an integrated and life-cycle balanced set of system people, product, and process solutions that satisfy customer needs". Designing reliable space-based systems has always been a goal for NASA, and many painful lessons have been learned along the way. One of the continuing functions of a system engineer is to compile development and operations "lessons learned" documents and ensure their integration into future systems development activities. They can produce insights and information for risk identification identification and characterization. on a new project. Lessons learned files from previous projects are especially valuable in risk

  5. Exo-Skeletal Engine: Novel Engine Concept

    NASA Technical Reports Server (NTRS)

    Chamis, Cristos C.; Blankson, Isaiah M.

    2004-01-01

    The exo-skeletal engine concept represents a new radical engine technology with the potential to substantially revolutionize engine design. It is an all-composite drum-rotor engine in which conventionally heavy shafts and discs are eliminated and are replaced by rotating casings that support the blades in spanwise compression. Thus the rotating blades are in compression rather than tension. The resulting open channel at the engine centerline has immense potential for jet noise reduction and can also accommodate an inner combined-cycle thruster such as a ramjet. The exo-skeletal engine is described in some detail with respect to geometry, components, and potential benefits. Initial evaluations and results for drum rotors, bearings, and weights are summarized. Component configuration, assembly plan, and potential fabrication processes are also identified. A finite element model of the assembled engine and its major components is described. Preliminary results obtained thus far show at least a 30-percent reduction of engine weight and about a 10-dB noise reduction, compared with a baseline conventional high-bypass-ratio engine. Potential benefits in all aspects of this engine technology are identified and tabulated. Quantitative assessments of potential benefits are in progress.

  6. High School Engineering: Pre-Engineering for Future Engineers.

    ERIC Educational Resources Information Center

    Sutter, Gary R.

    1998-01-01

    Describes a course that bridges the gap between pure science and pure technology called Pre-Engineering. This course gives junior and senior students a chance to investigate the possibility of choosing engineering as a major in college as well as to experience hands-on activities, projects, laboratories, problem solving, and computer simulations…

  7. 14 CFR 27.1521 - Powerplant limitations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... engine torque. For rotorcraft with main rotors driven by turboshaft engines, and that do not have a torque limiting device in the transmission system, the following apply: (1) A limit engine torque must be established if the maximum torque that the engine can exert is greater than— (i) The torque that the...

  8. 14 CFR 27.1521 - Powerplant limitations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... engine torque. For rotorcraft with main rotors driven by turboshaft engines, and that do not have a torque limiting device in the transmission system, the following apply: (1) A limit engine torque must be established if the maximum torque that the engine can exert is greater than— (i) The torque that the...

  9. 14 CFR 27.1521 - Powerplant limitations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... engine torque. For rotorcraft with main rotors driven by turboshaft engines, and that do not have a torque limiting device in the transmission system, the following apply: (1) A limit engine torque must be established if the maximum torque that the engine can exert is greater than— (i) The torque that the...

  10. 14 CFR 27.1521 - Powerplant limitations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... engine torque. For rotorcraft with main rotors driven by turboshaft engines, and that do not have a torque limiting device in the transmission system, the following apply: (1) A limit engine torque must be established if the maximum torque that the engine can exert is greater than— (i) The torque that the...

  11. Space Transportation Main Engine

    NASA Technical Reports Server (NTRS)

    Monk, Jan C.

    1992-01-01

    The topics are presented in viewgraph form and include the following: Space Transportation Main Engine (STME) definition, design philosophy, robust design, maximum design condition, casting vs. machined and welded forgings, operability considerations, high reliability design philosophy, engine reliability enhancement, low cost design philosophy, engine systems requirements, STME schematic, fuel turbopump, liquid oxygen turbopump, main injector, and gas generator. The major engine components of the STME and the Space Shuttle Main Engine are compared.

  12. Software Engineering Guidebook

    NASA Technical Reports Server (NTRS)

    Connell, John; Wenneson, Greg

    1993-01-01

    The Software Engineering Guidebook describes SEPG (Software Engineering Process Group) supported processes and techniques for engineering quality software in NASA environments. Three process models are supported: structured, object-oriented, and evolutionary rapid-prototyping. The guidebook covers software life-cycles, engineering, assurance, and configuration management. The guidebook is written for managers and engineers who manage, develop, enhance, and/or maintain software under the Computer Software Services Contract.

  13. Teaching Engineering Practices

    NASA Astrophysics Data System (ADS)

    Cunningham, Christine M.; Carlsen, William S.

    2014-03-01

    Engineering is featured prominently in the Next Generation Science Standards (NGSS) and related reform documents, but how its nature and methods are described is problematic. This paper is a systematic review and critique of that representation, and proposes that the disciplinary core ideas of engineering (as described in the NGSS) can be disregarded safely if the practices of engineering are better articulated and modeled through student engagement in engineering projects. A clearer distinction between science and engineering practices is outlined, and prior research is described that suggests that precollege engineering design can strengthen children's understandings about scientific concepts. However, a piecemeal approach to teaching engineering practices is unlikely to result in students understanding engineering as a discipline. The implications for science teacher education are supplemented with lessons learned from a number of engineering education professional development projects.

  14. Humanitarian engineering in the engineering curriculum

    NASA Astrophysics Data System (ADS)

    Vandersteen, Jonathan Daniel James

    There are many opportunities to use engineering skills to improve the conditions for marginalized communities, but our current engineering education praxis does not instruct on how engineering can be a force for human development. In a time of great inequality and exploitation, the desire to work with the impoverished is prevalent, and it has been proposed to adjust the engineering curriculum to include a larger focus on human needs. This proposed curriculum philosophy is called humanitarian engineering. Professional engineers have played an important role in the modern history of power, wealth, economic development, war, and industrialization; they have also contributed to infrastructure, sanitation, and energy sources necessary to meet human need. Engineers are currently at an important point in time when they must look back on their history in order to be more clear about how to move forward. The changing role of the engineer in history puts into context the call for a more balanced, community-centred engineering curriculum. Qualitative, phenomenographic research was conducted in order to understand the need, opportunity, benefits, and limitations of a proposed humanitarian engineering curriculum. The potential role of the engineer in marginalized communities and details regarding what a humanitarian engineering program could look like were also investigated. Thirty-two semi-structured research interviews were conducted in Canada and Ghana in order to collect a pool of understanding before a phenomenographic analysis resulted in five distinct outcome spaces. The data suggests that an effective curriculum design will include teaching technical skills in conjunction with instructing about issues of social justice, social location, cultural awareness, root causes of marginalization, a broader understanding of technology, and unlearning many elements about the role of the engineer and the dominant economic/political ideology. Cross-cultural engineering development

  15. Service Cart For Engines

    NASA Technical Reports Server (NTRS)

    Ng, Gim Shek

    1995-01-01

    Cart supports rear-mounted air-cooled engine from Volkswagen or Porsche automobile. One person removes, repairs, tests, and reinstalls engine of car, van, or home-built airplane. Consists of framework of wood, steel, and aluminum components supported by four wheels. Engine lifted from vehicle by hydraulic jack and gently lowered onto waiting cart. Jack removed from under engine. Rear of vehicle raised just enough that engine can be rolled out from under it. Cart easily supports 200-lb engine. Also used to hold transmission. With removable sheet-metal top, cart used as portable seat.

  16. Improving engineering effectiveness

    NASA Technical Reports Server (NTRS)

    Fiero, J. D.

    1985-01-01

    Methodologies to improve engineering productivity were investigated. The rocky road to improving engineering effectiveness is reviewed utilizing a specific semiconductor engineering organization as a case study. The organization had a performance problem regarding new product introductions. With the help of this consultant as a change agent the engineering team used a systems approach to through variables that were effecting their output significantly. Critical factors for improving this engineering organization's effectiveness and the roles/responsibilities of management, the individual engineers and the internal consultant are discussed.

  17. The Phillips Stirling engine

    SciTech Connect

    Hargreaves, C.M.

    1991-01-01

    This book is about the Stirling engine and its development from the heavy cast-iron machine of the 19th century to that of today. It is a history of a research effort spanning nearly 50 years, together with an outline of principles, and some technical details and descriptions of the more important engines. Contents include: the hot-air engine; the 20th-century revival; the Stirling cycle; rhombic-drive engines; heating and cooling; pistons and seals; electric generators and heat pumps; exotic heat sources; the engine and the environment; swashplate engines; and the past and the future.

  18. Tripropellant engine study

    NASA Technical Reports Server (NTRS)

    Wheeler, D. B.

    1978-01-01

    Engine performance data, combustion gas thermodynamic properties, and turbine gas parameters were determined for various high power cycle engine configurations derived from the space shuttle main engine that will allow sequential burning of LOX/hydrocarbon and LOX/hydrogen fuels. Both stage combustion and gas generator pump power cycles were considered. Engine concepts were formulated for LOX/RP-1, LOX/CH4, and LOX/C3H8 propellants. Flowrates and operating conditions were established for this initial set of engine systems, and the adaptability of the major components of shuttle main engine was investigated.

  19. Infusing Engineering Concepts: Teaching Engineering Design

    ERIC Educational Resources Information Center

    Daugherty, Jenny

    2012-01-01

    Engineering has gained considerable traction in many K-12 schools. However, there are several obstacles or challenges to an effective approach that leads to student learning. Questions such as where engineering best fits in the curriculum; how to include it authentically and appropriately; toward what educational end; and how best to prepare…

  20. Advanced Natural Gas Reciprocating Engine(s)

    SciTech Connect

    Pike, Edward

    2014-03-31

    The objective of the Cummins ARES program, in partnership with the US Department of Energy (DOE), is to develop advanced natural gas engine technologies that increase engine system efficiency at lower emissions levels while attaining lower cost of ownership. The goals of the project are to demonstrate engine system achieving 50% Brake Thermal Efficiency (BTE) in three phases, 44%, 47% and 50% (starting baseline efficiency at 36% BTE) and 0.1 g/bhp-hr NOx system out emissions (starting baseline NOx emissions at 2 – 4 g/bhp-hr NOx). Primary path towards above goals include high Brake Mean Effective Pressure (BMEP), improved closed cycle efficiency, increased air handling efficiency and optimized engine subsystems. Cummins has successfully demonstrated each of the phases of this program. All targets have been achieved through application of a combined set of advanced base engine technologies and Waste Heat Recovery from Charge Air and Exhaust streams, optimized and validated on the demonstration engine and other large engines. The following architectures were selected for each Phase: Phase 1: Lean Burn Spark Ignited (SI) Key Technologies: High Efficiency Turbocharging, Higher Efficiency Combustion System. In production on the 60/91L engines. Over 500MW of ARES Phase 1 technology has been sold. Phase 2: Lean Burn Technology with Exhaust Waste Heat Recovery (WHR) System Key Technologies: Advanced Ignition System, Combustion Improvement, Integrated Waste Heat Recovery System. Base engine technologies intended for production within 2 to 3 years Phase 3: Lean Burn Technology with Exhaust and Charge Air Waste Heat Recovery System Key Technologies: Lower Friction, New Cylinder Head Designs, Improved Integrated Waste Heat Recovery System. Intended for production within 5 to 6 years Cummins is committed to the launch of next generation of large advanced NG engines based on ARES technology to be commercialized worldwide.

  1. Engineering Ethics in the Subject of Engineering History

    NASA Astrophysics Data System (ADS)

    Isohata, Hiroshi

    Engineering ethics has been focused in the field of engineering education since the introduction of accreditation system of engineering education. In this paper, contents of the subject of engineering history are examined and discussed from the viewpoints of education of engineering ethics through a practical case of civil engineering history in a college. For the first step, codes of engineering ethics regulated in various engineering organizations are analyzed and the common contents are extracted to set the requirements for the education of engineering ethics. Then contents of the subject of engineering history are examined according to the requirements. Finally, conditions of engineering history for engineering ethics are discussed.

  2. Structural Engineering: Overview

    NASA Technical Reports Server (NTRS)

    Castro, Edgar

    2011-01-01

    This slide presentation presents the work of the Structural Engineering Division of the Engineering Directorate. The work includes: providing technical expertise and leadership for the development, evaluation, and operation of structural, mechanical, and thermal spaceflight systems.

  3. Chemical Engineering Education Revisited.

    ERIC Educational Resources Information Center

    Theodore, Louis

    1978-01-01

    The opinion is presented that chemical engineering education seems to emphasize the professor's research and/or professional interests with little regard for the real needs of the student who intends to become a practicing engineer. (BB)

  4. Chemical Engineering Division Activities

    ERIC Educational Resources Information Center

    Chemical Engineering Education, 1978

    1978-01-01

    The 1978 ASEE Chemical Engineering Division Lecturer was Theodore Vermeulen of the University of California at Berkeley. Other chemical engineers who received awards or special recognition at a recent ASEE annual conference are mentioned. (BB)

  5. Twin engine synchronizer

    SciTech Connect

    Kobus, J.R.

    1988-05-03

    This patent describes an apparatus for synchronizing the speeds of two engines, each having its own throttle level connected by an associated cable to a respective hand throttle lever, comprising moving means carried by the throttle lever of one of the engines for moving the throttle lever of the one engine independently of its associated cable and its respective hand throttle lever to increase or decrease the speed of the one engine until the speed of the one engine matches the speed of the other engine. The moving means moves the throttle lever of the one engine without moving its associated cable or its respective hand throttle lever, and actuating means mounted remote from the throttle lever of the one engine for actuating the moving means.

  6. Aircraft Engine Emissions. [conference

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A conference on a aircraft engine emissions was held to present the results of recent and current work. Such diverse areas as components, controls, energy efficient engine designs, and noise and pollution reduction are discussed.

  7. Russian Rocket Engine Test

    NASA Technical Reports Server (NTRS)

    1998-01-01

    NASA engineers successfully tested a Russian-built rocket engine on November 4, 1998 at the Marshall Space Flight Center (MSFC) Advanced Engine Test Facility, which had been used for testing the Saturn V F-1 engines and Space Shuttle Main engines. The MSFC was under a Space Act Agreement with Lockheed Martin Astronautics of Denver to provide a series of test firings of the Atlas III propulsion system configured with the Russian-designed RD-180 engine. The tests were designed to measure the performance of the Atlas III propulsion system, which included avionics and propellant tanks and lines, and how these components interacted with the RD-180 engine. The RD-180 is powered by kerosene and liquid oxygen, the same fuel mix used in Saturn rockets. The RD-180, the most powerful rocket engine tested at the MSFC since Saturn rocket tests in the 1960s, generated 860,000 pounds of thrust.

  8. Engineering students' sustainability approaches

    NASA Astrophysics Data System (ADS)

    Haase, S.

    2014-05-01

    Sustainability issues are increasingly important in engineering work all over the world. This article explores systematic differences in self-assessed competencies, interests, importance, engagement and practices of newly enrolled engineering students in Denmark in relation to environmental and non-environmental sustainability issues. The empirical base of the article is a nation-wide, web-based survey sent to all newly enrolled engineering students in Denmark commencing their education in the fall term 2010. The response rate was 46%. The survey focused on a variety of different aspects of what can be conceived as sustainability. By means of cluster analysis, three engineering student approaches to sustainability are identified and described. The article provides knowledge on the different prerequisites of engineering students in relation to the role of sustainability in engineering. This information is important input to educators trying to target new engineering students and contribute to the provision of engineers equipped to meet sustainability challenges.

  9. Carburetion in aviation engines

    NASA Technical Reports Server (NTRS)

    POINCARE

    1923-01-01

    This report tries to solve the problem of supplying the engine cylinders with a mixture of fuel and air in the right ratio to obtain the greatest power from the engine with the least consumption of fuel.

  10. Rotorcraft convertible engine study

    NASA Technical Reports Server (NTRS)

    Gill, J. C.; Earle, R. V.; Mar, H. M.

    1982-01-01

    The objective of the Rotorcraft Convertible Engine Study was to define future research and technology effort required for commercial development by 1988 of convertible fan/shaft gas turbine engines for unconventional rotorcraft transports. Two rotorcraft and their respective missions were defined: a Fold Tilt Rotor aircraft and an Advancing Blade Concept (ABC) rotorcraft. Sensitivity studies were conducted with these rotorcraft to determine parametrically the influence of propulsion characteristics on aircraft size, mission fuel requirements, and direct operating costs (DOC). The two rotorcraft were flown with conventional propulsion systems (separate lift/cruise engines) and with convertible propulsion systems to determine the benefits to be derived from convertible engines. Trade-off studies were conducted to determine the optimum engine cycle and staging arrangement for a convertible engine. Advanced technology options applicable to convertible engines were studied. Research and technology programs were identified which would ensure technology readiness for commercial development of convertible engines by 1988.

  11. Educating the Engineer.

    ERIC Educational Resources Information Center

    Wallace, Melanie; Wallace, Mack

    2003-01-01

    Presented as a conversation between a teacher and engineer about school design, addresses educators' preferences and engineers' perspectives on issues, such as windows, sustainable design, sinks, acoustics, and natural ventilation. (EV)

  12. Liquid piston Stirling engines

    SciTech Connect

    West, C.D.

    1983-01-01

    This book is a presentation on piston stirling engines. Topics covered include: liquid piston engines; basic design and power calculations; more advanced power calculations; design example; and past research work and some present research needs.

  13. BENCHMARKING SUSTAINABILITY ENGINEERING EDUCATION

    EPA Science Inventory

    The goals of this project are to develop and apply a methodology for benchmarking curricula in sustainability engineering and to identify individuals active in sustainability engineering education.

  14. NASA Systems Engineering Handbook

    NASA Technical Reports Server (NTRS)

    Shishko, Robert; Aster, Robert; Chamberlain, Robert G.; Mcduffee, Patrick; Pieniazek, Les; Rowell, Tom; Bain, Beth; Cox, Renee I.; Mooz, Harold; Polaski, Lou

    1995-01-01

    This handbook brings the fundamental concepts and techniques of systems engineering to NASA personnel in a way that recognizes the nature of NASA systems and environment. It is intended to accompany formal NASA training courses on systems engineering and project management when appropriate, and is designed to be a top-level overview. The concepts were drawn from NASA field center handbooks, NMI's/NHB's, the work of the NASA-wide Systems Engineering Working Group and the Systems Engineering Process Improvement Task team, several non-NASA textbooks and guides, and material from independent systems engineering courses taught to NASA personnel. Five core chapters cover systems engineering fundamentals, the NASA Project Cycle, management issues in systems engineering, systems analysis and modeling, and specialty engineering integration. It is not intended as a directive. Superseded by: NASA/SP-2007-6105 Rev 1 (20080008301).

  15. COBRA Main Engine Project

    NASA Technical Reports Server (NTRS)

    Snoddy, Jim; Sides, Steve; Lyles, Garry M. (Technical Monitor)

    2002-01-01

    The COBRA (CO-Optimized Booster for Reusable Applications) project include the following: 1. COBRA main engine project team. 2. COBRA and RLX cycles selected. 3. COBRA proto-type engine approach enables mission success. 4. COBRA provides quick, low cost demo of cycle and technologies. 5. COBRA cycle I risk reduction supports. 6. Achieving engine safety. 6. RLX cycle I risk reduction supports. 7. Flight qualification. 9. Life extension engine testing.

  16. Cruise Missile Engines

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Williams International's F107 fanjet engine is used in two types of cruise missiles, Navy-sponsored Tomahawk and the Air Force AGM-86B Air Launched Cruise Missile (ALCM). Engine produces about 600 pounds thrust, is one foot in diameter and weighs only 141 pounds. Design was aided by use of a COSMIC program in calculating airflows in engine's internal ducting, resulting in a more efficient engine with increased thrust and reduced fuel consumption.

  17. Deployable Engine Air Brake

    NASA Technical Reports Server (NTRS)

    2014-01-01

    On approach, next-generation aircraft are likely to have airframe noise levels that are comparable to or in excess of engine noise. ATA Engineering, Inc. (ATA) is developing a novel quiet engine air brake (EAB), a device that generates "equivalent drag" within the engine through stream thrust reduction by creating a swirling outflow in the turbofan exhaust nozzle. Two Phase II projects were conducted to mature this technology: (1) a concept development program (CDP) and (2) a system development program (SDP).

  18. F-1 Engines

    NASA Technical Reports Server (NTRS)

    1965-01-01

    This photograph shows F-1 engines being stored in the F-1 Engine Preparation Shop, building 4666, at the Marshall Space Flight Center. Each F-1 engine produced a thrust of 1,500,000 pounds. A cluster of five engines was mounted on the thrust structure of the S-IC stage of a 364-foot long Saturn V launch vehicle that ultimately took astronauts to the Moon.

  19. Experimentation in software engineering

    NASA Technical Reports Server (NTRS)

    Basili, V. R.; Selby, R. W.; Hutchens, D. H.

    1986-01-01

    Experimentation in software engineering supports the advancement of the field through an iterative learning process. In this paper, a framework for analyzing most of the experimental work performed in software engineering over the past several years is presented. A variety of experiments in the framework is described and their contribution to the software engineering discipline is discussed. Some useful recommendations for the application of the experimental process in software engineering are included.

  20. Data management in engineering

    NASA Technical Reports Server (NTRS)

    Browne, J. C.

    1976-01-01

    An introduction to computer based data management is presented with an orientation toward the needs of engineering application. The characteristics and structure of data management systems are discussed. A link to familiar engineering applications of computing is established through a discussion of data structure and data access procedures. An example data management system for a hypothetical engineering application is presented.

  1. Program (systems) engineering

    NASA Technical Reports Server (NTRS)

    Baroff, Lynn E.; Easter, Robert W.; Pomphrey, Richard B.

    2004-01-01

    Program Systems Engineering applies the principles of Systems Engineering at the program level. Space programs are composed of interrelated elements which can include collections of projects, advanced technologies, information systems, etc. Some program elements are outside traditional engineering's physical systems, such as education and public outreach, public relations, resource flow, and interactions within the political environments.

  2. Educating More Engineers

    ERIC Educational Resources Information Center

    Environmental Science and Technology, 1973

    1973-01-01

    Indicates that there will be a substantially increased demand for environmental engineers during the next few years, especially in the areas of water pollution control and sanitary engineering. Educators see the need for additional engineering graduates and for improved environmental training programs in schools. (JR)

  3. Graduate Engineering Education Today

    ERIC Educational Resources Information Center

    Pettit, Joseph M.; Gere, James M.

    1969-01-01

    Describes rapid growth of graduate education in engineering between 1900 and 1969. Points out need for graduate curricula in engineering that are both practical and research-oriented. Adapted from paper presented at International Conference on the Trends in the Teaching and Training of Engineers, Paris, France, December 9-13, 1968, and at Second…

  4. Personality Characteristics of Engineers

    ERIC Educational Resources Information Center

    van der Molen, Henk T.; Schmidt, Henk G.; Kruisman, Gerard

    2007-01-01

    The objective of the current study was to investigate the personality characteristics of a group of engineers with a variety of years of experience. It was executed to remedy shortcomings of the literature concerning this issue and to produce suggestions for a postgraduate training programme for engineers. A total of 103 engineers were tested with…

  5. Principles of Naval Engineering.

    ERIC Educational Resources Information Center

    Naval Personnel Program Support Activity, Washington, DC.

    Fundamentals of shipboard machinery, equipment, and engineering plants are presented in this text prepared for engineering officers. A general description is included of the development of naval ships, ship design and construction, stability and buoyancy, and damage and casualty control. Engineering theories are explained on the background of ship…

  6. Engineering for All

    ERIC Educational Resources Information Center

    Lottero-Perdue, Pamela S.; Lovelidge, Sarah; Bowling, Erin

    2010-01-01

    As calls for science, technology, engineering, and mathematics (STEM) education at the elementary level become more vociferous, elementary teachers may be wondering whether engineering is meant for "all" students. However, the authors assert that engineering can be taught in inclusive environments. It may be especially empowering for those who…

  7. 40 CFR 90.116 - Certification procedure-determining engine displacement, engine class, and engine families.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... engine displacement, engine class, and engine families. 90.116 Section 90.116 Protection of Environment...-IGNITION ENGINES AT OR BELOW 19 KILOWATTS Emission Standards and Certification Provisions § 90.116 Certification procedure—determining engine displacement, engine class, and engine families. (a)...

  8. 40 CFR 90.116 - Certification procedure-determining engine displacement, engine class, and engine families.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... engine displacement, engine class, and engine families. 90.116 Section 90.116 Protection of Environment...-IGNITION ENGINES AT OR BELOW 19 KILOWATTS Emission Standards and Certification Provisions § 90.116 Certification procedure—determining engine displacement, engine class, and engine families. (a)...

  9. 20. Engine identified as a 'single cylinder vacuum assist engine ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. Engine identified as a 'single cylinder vacuum assist engine for the Tod tandem compound engine' showing crank end. - Carnegie Steel-Ohio Works, Steam Engines, 912 Salt Springs Road, Youngstown, Mahoning County, OH

  10. 21. Engine identified as a 'single cylinder vacuum assist engine ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    21. Engine identified as a 'single cylinder vacuum assist engine for Tod tandem compound engine' showing compressor. - Carnegie Steel-Ohio Works, Steam Engines, 912 Salt Springs Road, Youngstown, Mahoning County, OH

  11. Optimized hydrogen piston engines

    SciTech Connect

    Smith, J.R.

    1994-05-10

    Hydrogen piston engines can be simultaneously optimized for improved thermal efficiency and for extremely low emissions. Using these engines in constant-speed, constant-load systems such as series hybrid-electric automobiles or home cogeneration systems can result in significantly improved energy efficiency. For the same electrical energy produced, the emissions from such engines can be comparable to those from natural gas-fired steam power plants. These hydrogen-fueled high-efficiency, low-emission (HELE) engines are a mechanical equivalent of hydrogen fuel cells. HELE engines could facilitate the transition to a hydrogen fuel cell economy using near-term technology.

  12. Diesel engine combustion processes

    SciTech Connect

    1995-12-31

    Diesel Engine Combustion Processes guides the engineer and research technician toward engine designs which will give the ``best payoff`` in terms of emissions and fuel economy. Contents include: Three-dimensional modeling of soot and NO in a direct-injection diesel engine; Prechamber for lean burn for low NOx; Modeling and identification of a diesel combustion process with the downhill gradient search method; The droplet group micro-explosions in W/O diesel fuel emulsion sprays; Combustion process of diesel spray in high temperature air; Combustion process of diesel engines at regions with different altitude; and more.

  13. Armored Geomembrane Cover Engineering

    PubMed Central

    Foye, Kevin

    2011-01-01

    Geomembranes are an important component of modern engineered barriers to prevent the infiltration of stormwater and runoff into contaminated soil and rock as well as waste containment facilities—a function generally described as a geomembrane cover. This paper presents a case history involving a novel implementation of a geomembrane cover system. Due to this novelty, the design engineers needed to assemble from disparate sources the design criteria for the engineering of the cover. This paper discusses the design methodologies assembled by the engineering team. This information will aid engineers designing similar cover systems as well as environmental and public health professionals selecting site improvements that involve infiltration barriers. PMID:21776229

  14. Solar powered Stirling engine

    SciTech Connect

    Meijer, R.J.

    1987-11-24

    In a solar dish module which comprises a dish which receives incident solar rays and reflects them to a focus at which is located the combination of a receiver and a heat engine organized and arranged so that the heat energy of the reflected solar rays collected at the receiver powers the engine, and wherein the receiver and heat engine are supported from the dish by a framework, the improvement is described which comprises journal means for journaling at least the engine on the framework to maintain certain predetermined spatial orientation for the engine in relation to the direction of gravity irrespective of spatial orientation of the dish.

  15. Diagnosing diesel engines

    SciTech Connect

    O'Connor, L.

    1992-03-01

    This paper reports that problems with diesel engines that have reciprocating parts have long defied a systematic approach to analysis. Engine phenomena such as combustion pressures, valve seating impacts, and piston vibrations reflect directly on how an engine is performing and would be useful to measure. However, these occur inside an engine block and for the most part are not possible to measure directly with sensors. Diesel engine manufacturers are finding new ways to troubleshoot machinery by using sophisticated signal-processing techniques that detect combustion anomalies and high-speed data-acquisition units that sample multiple measurement parameters.

  16. Diesel engine catalytic combustor system. [aircraft engines

    NASA Technical Reports Server (NTRS)

    Ream, L. W. (Inventor)

    1984-01-01

    A low compression turbocharged diesel engine is provided in which the turbocharger can be operated independently of the engine to power auxiliary equipment. Fuel and air are burned in a catalytic combustor to drive the turbine wheel of turbine section which is initially caused to rotate by starter motor. By opening a flapper value, compressed air from the blower section is directed to catalytic combustor when it is heated and expanded, serving to drive the turbine wheel and also to heat the catalytic element. To start, engine valve is closed, combustion is terminated in catalytic combustor, and the valve is then opened to utilize air from the blower for the air driven motor. When the engine starts, the constituents in its exhaust gas react in the catalytic element and the heat generated provides additional energy for the turbine section.

  17. Stirling engine application study

    NASA Technical Reports Server (NTRS)

    Teagan, W. P.; Cunningham, D.

    1983-01-01

    A range of potential applications for Stirling engines in the power range from 0.5 to 5000 hp is surveyed. Over one hundred such engine applications are grouped into a small number of classes (10), with the application in each class having a high degree of commonality in technical performance and cost requirements. A review of conventional engines (usually spark ignition or Diesel) was then undertaken to determine the degree to which commercial engine practice now serves the needs of the application classes and to detemine the nature of the competition faced by a new engine system. In each application class the Stirling engine was compared to the conventional engines, assuming that objectives of ongoing Stirling engine development programs are met. This ranking process indicated that Stirling engines showed potential for use in all application classes except very light duty applications (lawn mowers, etc.). However, this potential is contingent on demonstrating much greater operating life and reliability than has been demonstrated to date by developmental Stirling engine systems. This implies that future program initiatives in developing Stirling engine systems should give more emphasis to life and reliability issues than has been the case in ongoing programs.

  18. Engineered phages for electronics.

    PubMed

    Cui, Yue

    2016-11-15

    Phages are traditionally widely studied in biology and chemistry. In recent years, engineered phages have attracted significant attentions for functionalization or construction of electronic devices, due to their specific binding, catalytic, nucleating or electronic properties. To apply the engineered phages in electronics, these are a number of interesting questions: how to engineer phages for electronics? How are the engineered phages characterized? How to assemble materials with engineered phages? How are the engineered phages micro or nanopatterned? What are the strategies to construct electronics devices with engineered phages? This review will highlight the early attempts to address these questions and explore the fundamental and practical aspects of engineered phages in electronics, including the approaches for selection or expression of specific peptides on phage coat proteins, characterization of engineered phages in electronics, assembly of electronic materials, patterning of engineered phages, and construction of electronic devices. It provides the methodologies and opens up ex-cit-ing op-por-tu-ni-ties for the development of a variety of new electronic materials and devices based on engineered phages for future applications. PMID:27322923

  19. Institute for Mechanical Engineering

    NASA Astrophysics Data System (ADS)

    The Institute of Mechanical Engineering has the objectives of supporting in Canada the following activities: improvement of vehicles, propulsion systems, and transportation-related facilities and services; improvements in the design and operation of maritime engineering works; protection of the environment; enhancement of energy flexibility; advancement of firms engaged in manufacturing and resource extraction; and related programs of other government departments and agencies. In 1990-91 the Institute, which had changed its name that year from the Division of Mechanical Engineering, consolidated its research activities from nine laboratories to six programs. Activities in these six programs are described: Advanced Manufacturing Technology, Coastal Zone Engineering, Cold Regions Engineering, Combustion and Fluids Engineering, Ground Transportation Technology, and Machinery and Engine Technology.

  20. Energy efficient aircraft engines

    NASA Technical Reports Server (NTRS)

    Chamberlin, R.; Miller, B.

    1979-01-01

    The three engine programs that constitute the propulsion portion of NASA's Aircraft Energy Efficiency Program are described, their status indicated, and anticipated improvements in SFC discussed. The three engine programs are (1) Engine Component Improvement--directed at current engines, (2) Energy Efficiency Engine directed at new turbofan engines, and (3) Advanced Turboprops--directed at technology for advanced turboprop--powered aircraft with cruise speeds to Mach 0.8. Unique propulsion system interactive ties to the airframe resulting from engine design features to reduce fuel consumption are discussed. Emphasis is placed on the advanced turboprop since it offers the largest potential fuel savings of the three propulsion programs and also has the strongest interactive ties to the airframe.

  1. Energy efficient aircraft engines

    NASA Technical Reports Server (NTRS)

    Chamberlin, R.; Miller, B.

    1979-01-01

    The three engine programs that constitute the propulsion portion of NASA's Aircraft Energy Efficiency Program are described, their status indicated, and anticipated improvements in SFC discussed. The three engine programs are: (1) engine component improvement, directed at current engines, (2) energy efficient engine, directed at new turbofan engines, and (3) advanced turboprops, directed at technology for advanced turboprop-powered aircraft with cruise speeds to Mach 0.8. Unique propulsion system interactive ties to the airframe resulting from engine design features to reduce fuel consumption are discussed. Emphasis is placed on the advanced turboprop since it offers the largest potential fuel savings of the three propulsion programs and also has the strongest interactive ties to the airframe.

  2. Flash melting of chondrule precursors in excess of 1600 C. Series 1: Type 2 (B1) chondrule composition experiments

    NASA Technical Reports Server (NTRS)

    Connolly, Harold C., Jr.; Hewins, Roger H.; Lofgren, Gary E.

    1993-01-01

    Several questions in chondrule production remain an enigma despite years of experiments. What were the melting temperatures experienced by chondrules? What were the physical characteristics of chondrule precursors? How and why did volatile elements (i.e. Na) found within chondrules survive the formation process? We present the initial results of a series of experiments designed to investigate the above questions by using flash melting to duplicate the melting stage of chondrule formation.

  3. What Chemistry To Teach Engineers?

    ERIC Educational Resources Information Center

    Hawkes, Stephen J.

    2000-01-01

    Examines possible general chemistry topics that would be most relevant and practical for engineering majors. Consults the Accreditation Board for Engineering and Technology (ABET), engineering textbooks, texts from other required subjects, and practicing engineers for recommendations. (Contains 24 references.) (WRM)

  4. Mechanical Engineering Department technical review

    SciTech Connect

    Carr, R.B.; Abrahamson, L.; Denney, R.M.; Dubois, B.E

    1982-01-01

    Technical achievements and publication abstracts related to research in the following Divisions of Lawrence Livermore Laboratory are reported in this biannual review: Nuclear Fuel Engineering; Nuclear Explosives Engineering; Weapons Engineering; Energy Systems Engineering; Engineering Sciences; Magnetic Fusion Engineering; and Material Fabrication. (LCL)

  5. A Powerful New Engine

    NASA Technical Reports Server (NTRS)

    2001-01-01

    Through Small Business Innovation Research (SBIR) funding from NASA's Glenn Research Center, Moller International created a new coating for rotary engines, which significantly improves the fuel consumption of a vehicle while reducing emissions. The new coatings are offered in the new Rotapower(R) engine, which is produced and distributed by Moller subsidiary, Freedom Motors, Inc. The coating allows the Rotapower engine to function smoother than other models, reducing wear and protecting the engine. The Rotapower engine has the ability to operate on a variety of fuels, including gasoline, natural gas, diesel, alcohol, and kerosene. A small and lightweight engine, it is projected to replace many of today's bulkier versions. The 10 horsepower model fits in the palm of one's hand, while the 160 horsepower model fits into a 5-gallon bucket. The clean running Rotapower engine is environmentally appealing, because it eliminates over 98 percent of the total emissions given off by traditional piston engines. Fewer pollutants are spewed into the air, making it especially attractive in areas where air pollution is a major problem. Due to the clean-burning nature of the engine, it meets the stringent standards set by the California Air Resources Board. The engine also has numerous commercial benefits in several types of recreational, industrial, and transportation applications, including personal watercraft, snowmobiles, portable generators. and pumps.

  6. Teaching cellular engineering.

    PubMed

    Hammer, Daniel A; Waugh, Richard E

    2006-02-01

    Cellular engineering is one of the fastest growing subdisciplines in the field of Biomedical Engineering. It involves the application of engineering analysis to understand and control cellular behavior, with the ultimate objective of developing novel therapeutic or diagnostic approaches for the clinic or harnessing cellular function for commercial applications. Well-educated students in this area need strong foundational knowledge in engineering science, chemistry, and cell and molecular biology. In undergraduate curricula, the challenge is to include essential engineering skills plus appropriate levels of training in chemistry and biology while satisfying accreditation-mandated breadth in engineering training. At the graduate level, educators must accommodate students with diverse backgrounds and provide them with both a state-of-the-art understanding of the life sciences and the most advanced engineering skills. Engineering curricular content should include mechanics and materials, physical chemistry, transport phenomena, and control theory. Training from faculty with appointments and research programs in the life sciences is generally recommended, and additional life science content should also be integrated within the engineering curriculum. A capstone course in cellular engineering that includes opportunities for students to have hands-on experiences with state-of-the-art laboratory techniques is highly recommended. PMID:16450196

  7. Liquid rocket engine test facility engineering challenges

    NASA Astrophysics Data System (ADS)

    Ellerbrock, Hartwig; Ziegenhagen, Stefan

    2006-12-01

    Liquid rocket engines for launch vehicles and space crafts as well as their subsystems need to be verified and qualified during hot-runs. A high test cadence combined with a flexible test team helps to reduce the cost for test verification during development/qualification as well as during acceptance testing for production. Test facility intelligence allows to test subsystems in the same manner as during complete engine system tests and will therefore reduce development time and cost. This paper gives an overview of the maturing of test engineering know how for rocket engine test stands as well as high altitude test stands for small propulsion thrusters at EADS-ST in Ottobrunn and Lampoldshausen and is split into two parts: Part 1 gives a historical overview of the EADS-ST test stands at Ottobrunn and Lampoldshausen since the beginning of Rocket propulsion activities in the 1960s. Part 2 gives an overview of the actual test capabilities and the test engineering know-how for test stand construction/adaptation and their use during running programs. Examples of actual realised facility concepts are given to demonstrate cost saving potential for test programs in both cases for development/qualification issues as well as for production purposes.

  8. Performance of Stirling Engines

    NASA Astrophysics Data System (ADS)

    Iwamoto, Shoichi; Hirata, Koichi; Toda, Fujio

    We have developed five kinds of high- and low-temperature differential Stirling engines and their engine performance was investigated experimentally. In order to determine the parameters that affect engine performance, experimental results were discussed and compared with results calculated using analytical methods. We show an arranging method for the experimental results, and consider the performance of general Stirling engines. After using the arranging method with nondimensional numbers obtained by a dimensional analysis, a prediction method, which is used at the early design stage, is formulated. One of the nondimensional numbers in this prediction method is calculated based on engine specifications, including the properties of the working gas. The prediction method can predict engine speed, output power, the effect of working gas and operating conditions.

  9. Staged combustion with piston engine and turbine engine supercharger

    DOEpatents

    Fischer, Larry E.; Anderson, Brian L.; O'Brien, Kevin C.

    2011-11-01

    A combustion engine method and system provides increased fuel efficiency and reduces polluting exhaust emissions by burning fuel in a two-stage combustion system. Fuel is combusted in a piston engine in a first stage producing piston engine exhaust gases. Fuel contained in the piston engine exhaust gases is combusted in a second stage turbine engine. Turbine engine exhaust gases are used to supercharge the piston engine.

  10. Staged combustion with piston engine and turbine engine supercharger

    DOEpatents

    Fischer, Larry E.; Anderson, Brian L.; O'Brien, Kevin C.

    2006-05-09

    A combustion engine method and system provides increased fuel efficiency and reduces polluting exhaust emissions by burning fuel in a two-stage combustion system. Fuel is combusted in a piston engine in a first stage producing piston engine exhaust gases. Fuel contained in the piston engine exhaust gases is combusted in a second stage turbine engine. Turbine engine exhaust gases are used to supercharge the piston engine.

  11. Advanced rotary engine studies

    NASA Technical Reports Server (NTRS)

    Jones, C.

    1980-01-01

    A review of rotary engine developments relevant to a stratified charge rotary aircraft engine is presented. Advantages in module size and weight, fuel efficiency, reliability, and multi-fuel capability are discussed along with developments in turbocharging, increased mean effective pressure, improved apex seal/trochoid wear surfacing materials, and high strength and temperature aluminum casting alloys. A carbureted prototype aircraft engine is also described.

  12. Engineered human vaccines

    SciTech Connect

    Sandhu, J.S. . Div. of Immunology and Neurobiology)

    1994-01-01

    The limitations of human vaccines in use at present and the design requirements for a new generation of human vaccines are discussed. The progress in engineering of human vaccines for bacteria, viruses, parasites, and cancer is reviewed, and the data from human studies with the engineered vaccines are discussed, especially for cancer and AIDS vaccines. The final section of the review deals with the possible future developments in the field of engineered human vaccines and the requirement for effective new human adjuvants.

  13. Advanced rotary engines

    NASA Technical Reports Server (NTRS)

    Jones, C.

    1983-01-01

    The broad objectives of this paper are the following: (1) to summarize the Curtiss-Wright design, development and field testing background in the area of rotary aircraft engines; (2) to briefly summarize past activity and update development work in the area of stratified charge rotary combustion engines; and (3) to discuss the development of a high-performance direct injected unthrottled stratified charge rotary combustion aircraft engine. Efficiency improvements through turbocharging are also discussed.

  14. [Bone tissue engineering scaffolds].

    PubMed

    Fang, Liru; Weng, Wenjian; Shen, Ge; Han, Gaorong; Santos, J D; Du, Peiyi

    2003-03-01

    Bone tissue engineering may provide an alternative to the repairs to skeletal defects resulting from disease, trauma or surgery. Scaffold has played an important role in bone tissue engineering, which functions as the architecture for bone in growth. In this paper, the authors gave a brief introduction about the requirement of bone tissue engineering scaffold, the key of the design of scaffolds and the current research on this subject. PMID:12744187

  15. Stirling engine heating system

    SciTech Connect

    Johansson, L.N.; Houtman, W.H.; Percival, W.H.

    1988-06-28

    A hot gas engine is described wherein a working gas flows back and forth in a closed path between a relatively cooler compression cylinder side of the engine and a relatively hotter expansion cylinder side of the engine and the path contains means including a heat source and a heat sink acting upon the gas in cooperation with the compression and expansion cylinders to cause the gas to execute a thermodynamic cycle wherein useful mechanical output power is developed by the engine, the improvement in the heat source which comprises a plurality of individual tubes each forming a portion of the closed path for the working gas.

  16. Stirling Engine Heat Pump

    NASA Astrophysics Data System (ADS)

    Kagawa, Noboru

    Recent advances in the feasibility studies related to the Stirling engines and Stirling engine heat pumps which have been considered attractive due to their promising role in helping to solve the global environmental and energy problems,are reviewed. This article begins to describe the brief history of the Stirling engines and theoretical thermodynamic analysis of the Stirling cycle in order to understand several advantages on the Stirling engine. Furthermore,they could throw light on our question why the dream engines had not been promoted to practical applications during two hundred years. The present review shows that the Stirling engines with several unique advantages including 30 to 40% thermal efficiency and preferable exhaust characteristics,had been designed and constructed by recent tackling for the development of the advanced automobile and other applications using them. Based on the current state of art,it is being provided to push the Stirling engines combined with heat pumps based on the reversed Rankine cycle to the market. At present,however, many problems, especially for the durability, cost, and delicate engine parts must be enforced to solve. In addition,there are some possibilities which can increase the attractiveness of the Stirling engines and heat pumps. The review closes with suggestions for further research.

  17. Russian Rocket Engine Test

    NASA Technical Reports Server (NTRS)

    1998-01-01

    NASA engineers successfully tested a Russian-built rocket engine on November 4, 1998 at the Marshall Space Flight Center (MSFC) Advanced Engine Test Facility, which had been used for testing the Saturn V F-1 engines and Space Shuttle Main engines. The MSFC was under a Space Act Agreement with Lockheed Martin Astronautics of Denver to provide a series of test firings of the Atlas III propulsion system configured with the Russian-designed RD-180 engine. The tests were designed to measure the performance of the Atlas III propulsion system, which included avionics and propellant tanks and lines, and how these components interacted with the RD-180 engine. The RD-180 is powered by kerosene and liquid oxygen, the same fuel mix used in Saturn rockets. The RD-180, the most powerful rocket engine tested at the MSFC since Saturn rocket tests in the 1960s, generated 860,000 pounds of thrust. The test was the first test ever anywhere outside Russia of a Russian designed and built engine.

  18. Diesel Engine Alternatives

    SciTech Connect

    Ryan, T

    2003-08-24

    There are basically three different modes of combustion possible for use in reciprocating engines. These include, diffusion burning, as occurs in current diesel engines, flame propagation combustion such as used in conventional SI engines, and homogeneous combustion such as is used in the SwRI HCCI engine. Diesel engines currently offer significant fuel consumption benefits relative to other powerplants for on and off road applications; however, costs and efficiency may become problems as the emissions standards become even more stringent. This presentation presents a discussion of the potentials of HCCI and flame propagation engines as alternatives to the diesel engines. It is suggested that as the emissions standards become more and more stringent, the advantages of the diesel may disappear. The potential for HCCI is limited by the availability of the appropriate fuel. The potential of flame propagation engines is limited by several factors including knock, EGR tolerance, high BMEP operation, and throttling. These limitations are discussed in the context of potential for improvement of the efficiency of the flame propagation engine.

  19. Helicopter engine core noise

    NASA Astrophysics Data System (ADS)

    Vonglahn, U. H.

    1982-07-01

    Calculated engine core noise levels, based on NASA Lewis prediction procedures, for five representative helicopter engines are compared with measured total helicopter noise levels and ICAO helicopter noise certification requirements. Comparisons are made for level flyover and approach procedures. The measured noise levels are generally significantly greater than those predicted for the core noise levels, except for the Sikorsky S-61 and S-64 helicopters. However, the predicted engine core noise levels are generally at or within 3 dB of the ICAO noise rules. Consequently, helicopter engine core noise can be a significant contributor to the overall helicopter noise signature.

  20. Engine fuels from biomass

    NASA Astrophysics Data System (ADS)

    Parker, H. W.

    1981-01-01

    Sources of biomass fuels for engines are compared to other synfuels. Biomass can be converted to gaseous and liquid engine fuels by the same processes utilized for coal conversion such as gasification, direct liquefaction, and indirect liquefaction. Alternatively, biomass can be converted into liquid fuels by fermentation to methane or ethanol. The quantities of biomass derived engine fuels potentially available in the next decade are relatively small, and the anticipated costs are significantly greater than for liquid engine fuels made from coal or oil shale.

  1. Automatic engine control system

    SciTech Connect

    Geary, W.C.; Mirsaiidi, M.V.; Redfern, T.; Wolfe, D.W.

    1986-01-14

    This patent describes an automatic control circuit for an internal combustion engine and clutch assembly. One component of this circuit is a timer for determining the time the engine is allowed to run and the clutch is engaged and a second period of time when the clutch is automatically disengaged. Associated with the timer is a starter means to start the engine during the first time period and a clutch actuating mechanism for engaging the clutch near the first time period initiation after the starter starts the engine. An engine shut down and clutch disengagement mechanism is also responsive to the first timer. The patent then goes on to describe a supplemental timer mechanism for determining a third and fourth period of time within the second time period such that the third period being when the engine is shut off and the fourth period being when the engine runs with clutch disengaged. The starter mechanism is responsive to the supplemental timer to start the engine at the beginning of the fourth period. A shut down means stops the engine at the beginning of the third period in response to the timer.

  2. Rotary engine cooling system

    NASA Technical Reports Server (NTRS)

    Jones, Charles (Inventor); Gigon, Richard M. (Inventor); Blum, Edward J. (Inventor)

    1985-01-01

    A rotary engine has a substantially trochoidal-shaped housing cavity in which a rotor planetates. A cooling system for the engine directs coolant along a single series path consisting of series connected groups of passages. Coolant enters near the intake port, passes downwardly and axially through the cooler regions of the engine, then passes upwardly and axially through the hotter regions. By first flowing through the coolest regions, coolant pressure is reduced, thus reducing the saturation temperature of the coolant and thereby enhancing the nucleate boiling heat transfer mechanism which predominates in the high heat flux region of the engine during high power level operation.

  3. Flight Test Engineering

    NASA Technical Reports Server (NTRS)

    Pavlock, Kate Maureen

    2013-01-01

    Although the scope of flight test engineering efforts may vary among organizations, all point to a common theme: flight test engineering is an interdisciplinary effort to test an asset in its operational flight environment. Upfront planning where design, implementation, and test efforts are clearly aligned with the flight test objective are keys to success. This chapter provides a top level perspective of flight test engineering for the non-expert. Additional research and reading on the topic is encouraged to develop a deeper understanding of specific considerations involved in each phase of flight test engineering.

  4. F-1 Engine Assembly

    NASA Technical Reports Server (NTRS)

    1968-01-01

    A complete F-1 engine assembly is shown in this photograph. Designed and developed by Rocketdye under the direction of the Marshall Space Flight Center, the engine measured 19-feet tall by 12.5 feet at the nozzle exit, and each engine produced a 1,500,000-pound thrust using liquid oxygen and kerosene as the propellant. A cluster of five F-1 engines was mounted on the Saturn V S-IC (first) stage and burned 15 tons of liquid oxygen and kerosene each second to produce 7,500,000 pounds of thrust.

  5. Tripropellant engine study

    NASA Technical Reports Server (NTRS)

    Wheeler, D. B.; Kirby, F. M.

    1978-01-01

    The potential for converting the space shuttle main engine (SSME) to a dual-fuel, dual-mode engine using LOX/hydrocarbon propellants in mode 1 and LOX/H2 in mode 2 was examined. Various engine system concepts were formulated that included staged combustion and gas generator turbine power cycles, and LOX/RP-1, LOX/CH4, and LOX/C3H8 mode 1 propellants. Both oxidizer and fuel regenerative cooling were considered. All of the SSME major components were examined to determine their adaptability to the candidate dual-fuel engines.

  6. SOFIA Engineer Thomas Keilig

    NASA Video Gallery

    Thomas Keilig, the German Aerospace Agency's (DLR) chief telescope engineer for the Stratospheric Observatory for Infrared Astronomy (SOFIA), comments on technical details of the high-tech primary ...

  7. Rocket Engine Oscillation Diagnostics

    NASA Technical Reports Server (NTRS)

    Nesman, Tom; Turner, James E. (Technical Monitor)

    2002-01-01

    Rocket engine oscillating data can reveal many physical phenomena ranging from unsteady flow and acoustics to rotordynamics and structural dynamics. Because of this, engine diagnostics based on oscillation data should employ both signal analysis and physical modeling. This paper describes an approach to rocket engine oscillation diagnostics, types of problems encountered, and example problems solved. Determination of design guidelines and environments (or loads) from oscillating phenomena is required during initial stages of rocket engine design, while the additional tasks of health monitoring, incipient failure detection, and anomaly diagnostics occur during engine development and operation. Oscillations in rocket engines are typically related to flow driven acoustics, flow excited structures, or rotational forces. Additional sources of oscillatory energy are combustion and cavitation. Included in the example problems is a sampling of signal analysis tools employed in diagnostics. The rocket engine hardware includes combustion devices, valves, turbopumps, and ducts. Simple models of an oscillating fluid system or structure can be constructed to estimate pertinent dynamic parameters governing the unsteady behavior of engine systems or components. In the example problems it is shown that simple physical modeling when combined with signal analysis can be successfully employed to diagnose complex rocket engine oscillatory phenomena.

  8. Product engineering guide

    SciTech Connect

    McCarty, C.E.

    1989-12-01

    The semiconductor product engineers job requires knowledge and expertise related to many different subjects. This report provides guidance for newcomers to product engineering and is a consise reference for all others involved in product engineering. Subjects addressed are Customer/Supplier interactions, component development sequence, production schedule support, component characterization, product specifications, test equipment requirements, product qualification, characterization and development reports, preferred parts list, standard packaging, and finally, classification and security considerations. This guide is intended to help standardize and simplify the component development sequence presently used in the semiconductor product engineering department. 3 figs., 2 tabs.

  9. Helicopter engine core noise

    NASA Technical Reports Server (NTRS)

    Vonglahn, U. H.

    1982-01-01

    Calculated engine core noise levels, based on NASA Lewis prediction procedures, for five representative helicopter engines are compared with measured total helicopter noise levels and ICAO helicopter noise certification requirements. Comparisons are made for level flyover and approach procedures. The measured noise levels are generally significantly greater than those predicted for the core noise levels, except for the Sikorsky S-61 and S-64 helicopters. However, the predicted engine core noise levels are generally at or within 3 dB of the ICAO noise rules. Consequently, helicopter engine core noise can be a significant contributor to the overall helicopter noise signature.

  10. Advanced Natural Gas Reciprocating Engine(s)

    SciTech Connect

    Kwok, Doris; Boucher, Cheryl

    2009-09-30

    Energy independence and fuel savings are hallmarks of the nation’s energy strategy. The advancement of natural gas reciprocating engine power generation technology is critical to the nation’s future. A new engine platform that meets the efficiency, emissions, fuel flexibility, cost and reliability/maintainability targets will enable American manufacturers to have highly competitive products that provide substantial environmental and economic benefits in the US and in international markets. Along with Cummins and Waukesha, Caterpillar participated in a multiyear cooperative agreement with the Department of Energy to create a 50% efficiency natural gas powered reciprocating engine system with a 95% reduction in NOx emissions by the year 2013. This platform developed under this agreement will be a significant contributor to the US energy strategy and will enable gas engine technology to remain a highly competitive choice, meeting customer cost of electricity targets, and regulatory environmental standard. Engine development under the Advanced Reciprocating Engine System (ARES) program was divided into phases, with the ultimate goal being approached in a series of incremental steps. This incremental approach would promote the commercialization of ARES technologies as soon as they emerged from development and would provide a technical and commercial foundation of later-developing technologies. Demonstrations of the Phase I and Phase II technology were completed in 2004 and 2008, respectively. Program tasks in Phase III included component and system development and testing from 2009-2012. Two advanced ignition technology evaluations were investigated under the ARES program: laser ignition and distributed ignition (DIGN). In collaboration with Colorado State University (CSU), a laser ignition system was developed to provide ignition at lean burn and high boost conditions. Much work has been performed in Caterpillar’s DIGN program under the ARES program. This work

  11. Engine and method for operating an engine

    DOEpatents

    Lauper, Jr., John Christian; Willi, Martin Leo; Thirunavukarasu, Balamurugesh; Gong, Weidong

    2008-12-23

    A method of operating an engine is provided. The method may include supplying a combustible combination of reactants to a combustion chamber of the engine, which may include supplying a first hydrocarbon fuel, hydrogen fuel, and a second hydrocarbon fuel to the combustion chamber. Supplying the second hydrocarbon fuel to the combustion chamber may include at least one of supplying at least a portion of the second hydrocarbon fuel from an outlet port that discharges into an intake system of the engine and supplying at least a portion of the second hydrocarbon fuel from an outlet port that discharges into the combustion chamber. Additionally, the method may include combusting the combustible combination of reactants in the combustion chamber.

  12. Perturbing engine performance measurements to determine optimal engine control settings

    DOEpatents

    Jiang, Li; Lee, Donghoon; Yilmaz, Hakan; Stefanopoulou, Anna

    2014-12-30

    Methods and systems for optimizing a performance of a vehicle engine are provided. The method includes determining an initial value for a first engine control parameter based on one or more detected operating conditions of the vehicle engine, determining a value of an engine performance variable, and artificially perturbing the determined value of the engine performance variable. The initial value for the first engine control parameter is then adjusted based on the perturbed engine performance variable causing the engine performance variable to approach a target engine performance variable. Operation of the vehicle engine is controlled based on the adjusted initial value for the first engine control parameter. These acts are repeated until the engine performance variable approaches the target engine performance variable.

  13. Students' Changing Images of Engineering and Engineers. Research Brief

    ERIC Educational Resources Information Center

    Jocuns, Andrew; Stevens, Reed; Garrison, Lari; Amos, Daniel

    2008-01-01

    This study analyzes the images of engineers and engineering that students construct over the course of their undergraduate engineering educations. Students in their first year of study to become engineers knew very little about the work they would be doing as an engineer and their expectations were more specific, hopeful, and high status than…

  14. Engineering Sustainable Engineers through the Undergraduate Experience

    ERIC Educational Resources Information Center

    Weatherton, Yvette Pearson; Sattler, Melanie; Mattingly, Stephen; Chen, Victoria; Rogers, Jamie; Dennis, Brian

    2012-01-01

    In order to meet the challenges of sustainable development, our approach to education must be modified to equip students to evaluate alternatives and devise solutions that meet multi-faceted requirements. In 2009, faculty in the Departments of Civil, Industrial and Mechanical Engineering at the University of Texas at Arlington began implementation…

  15. Courseware Engineering Methodology.

    ERIC Educational Resources Information Center

    Uden, Lorna

    2002-01-01

    Describes development of the Courseware Engineering Methodology (CEM), created to guide novices in designing effective courseware. Discusses CEM's four models: pedagogical (concerned with the courseware's pedagogical aspects), conceptual (dealing with software engineering), interface (relating to human-computer interaction), and hypermedia…

  16. Stirling engine design manual

    NASA Technical Reports Server (NTRS)

    Martini, W. R.

    1978-01-01

    This manual is intended to serve both as an introduction to Stirling engine analysis methods and as a key to the open literature on Stirling engines. Over 800 references are listed and these are cross referenced by date of publication, author and subject. Engine analysis is treated starting from elementary principles and working through cycles analysis. Analysis methodologies are classified as first, second or third order depending upon degree of complexity and probable application; first order for preliminary engine studies, second order for performance prediction and engine optimization, and third order for detailed hardware evaluation and engine research. A few comparisons between theory and experiment are made. A second order design procedure is documented step by step with calculation sheets and a worked out example to follow. Current high power engines are briefly described and a directory of companies and individuals who are active in Stirling engine development is included. Much remains to be done. Some of the more complicated and potentially very useful design procedures are now only referred to. Future support will enable a more thorough job of comparing all available design procedures against experimental data which should soon be available.

  17. Biological handbook for engineers

    NASA Technical Reports Server (NTRS)

    1970-01-01

    Microbiological background information is compiled in handbook for engineers and scientists working on bio-related projects. It is intended as aid in - /1/ evaluating effects of engineering procedures on microbial life, /2/ determining effects of decontamination and sterilization on performance of overall systems, and /3/ understanding language of microbiologists.

  18. NASA Engineering Network (NEN)

    NASA Technical Reports Server (NTRS)

    Topousis, Daria; Trevarthen, Ellie; Yew, Manson

    2008-01-01

    This slide presentation reviews the NASA Engineering Network (NEN). NEN is designed to search documents over multiple repositories, submit and browse NASA Lessons Learned, collaborate and share ideas with other engineers via communities of practice, access resources from one portal, and find subject matter experts via the People, Organizations, Projects, Skills (POPS) locator.

  19. Diesel Engine Technician

    ERIC Educational Resources Information Center

    Tech Directions, 2010

    2010-01-01

    Diesel engine technicians maintain and repair the engines that power transportation equipment such as heavy trucks, trains, buses, and locomotives. Some technicians work mainly on farm machines, ships, compressors, and pumps. Others work mostly on construction equipment such as cranes, power shovels, bulldozers, and paving machines. This article…

  20. Ann Wagner, Mechanical Engineer.

    ERIC Educational Resources Information Center

    Bennett, Betsy K.

    1996-01-01

    Presents a profile of Ann Wagner, a mechanical engineer at the Goddard Space Flight Center in Maryland, and her job responsibilities there. Also includes a brief history of mechanical engineering as well as a sample graph and data activity sheet with answers. (AIM)

  1. Mechanical Engineering Technology Curriculum.

    ERIC Educational Resources Information Center

    Georgia State Univ., Atlanta. Dept. of Vocational and Career Development.

    This guide offers information and procedures necessary to train mechanical engineering technicians. Discussed first are the rationale and objectives of the curriculum. The occupational field of mechanical engineering technology is described. Next, a curriculum model is set forth that contains information on the standard mechanical engineering…

  2. The Engineering Technician.

    ERIC Educational Resources Information Center

    American Society for Engineering Education, Washington, DC.

    Occupational and educational information concerning 12 categories of engineering technicians and engineering technology is presented. This information covers the role of the technicians, student qualifications, typical job titles, and typical educational programs. The categories presented are (1) air conditioning, heating, and refrigeration, (2)…

  3. Searches Conducted for Engineers.

    ERIC Educational Resources Information Center

    Lorenz, Patricia

    This paper reports an industrial information specialist's experience in performing online searches for engineers and surveys the databases used. Engineers seeking assistance fall into three categories: (1) those who recognize the value of online retrieval; (2) referrals by colleagues; and (3) those who do not seek help. As more successful searches…

  4. Computers in Engineering Teaching.

    ERIC Educational Resources Information Center

    Rushby, N. J.

    This bibliography cites 26 books, papers, and reports dealing with various uses of computers in engineering education; and describes several computer programs available for use in teaching aeronautical, chemical, civil, electrical and electronic, mechanical, and nuclear engineering. Each computer program entry is presented by name, author,…

  5. Test Pilot and Engineer

    NASA Technical Reports Server (NTRS)

    1920-01-01

    Goggles at the ready, this Langley test pilot and engineer conducted research business high above the ground. In the early years the flight research team was usually made up of a test pilot (Thomas Carroll, front cockpit) and an engineer (John W. Gus Crowley, Jr.).

  6. Family Style Engineering

    ERIC Educational Resources Information Center

    Smetana, Lara K.; Schumaker, Joan Chadde; Goldfien, Wendy Severin; Nelson, Cheryl

    2012-01-01

    Cunningham and Lachapelle (2011) found that most students have a naive understanding of the field of engineering, mistaking it for the work of technicians or artisans and neglecting to see the contributions engineers make to people's daily lives. In general, public (and teacher) understanding is not much more refined. These misconceptions about…

  7. SOFTWARE ENGINEERING INSTITUTE (SEI)

    EPA Science Inventory

    The Software Engineering Institute (SEI) is a federally funded research and development center established in 1984 by the U.S. Department of Defense and operated by Carnegie Mellon University. SEI has a broad charter to provide leadership in the practice of software engineering t...

  8. Small Gas Engine Repair.

    ERIC Educational Resources Information Center

    Connecticut State Dept. of Education, Hartford. Div. of Vocational-Technical Schools.

    Instructional materials are provided for a small gas engine course. A list of objectives appears first, followed by a list of internal parts and skills/competencies related to those parts for engine work, ignition and electrical systems, fuel system, crankcase lubrication system, arc welding skills, and gas welding skills. Outlines are provided…

  9. Knowledge Engineering and Education.

    ERIC Educational Resources Information Center

    Lopez, Antonio M., Jr.; Donlon, James

    2001-01-01

    Discusses knowledge engineering, computer software, and possible applications in the field of education. Highlights include the distinctions between data, information, and knowledge; knowledge engineering as a subfield of artificial intelligence; knowledge acquisition; data mining; ontology development for subject terms; cognitive apprentices; and…

  10. Engineering Design Concepts

    ERIC Educational Resources Information Center

    Fitzgerald, Mike

    2004-01-01

    In the author's opinion, the separation of content between science, math, engineering, and technology education should not exist. Working with the relationship between these content areas enhances students' efforts to learn about the physical world. In teaching students about design, technology, and engineering, attention should be given to the…

  11. Engineering for Everyone

    ERIC Educational Resources Information Center

    Cunningham, Christine M.; Higgins, Melissa

    2015-01-01

    The new Next Generation Science Standards make it a priority for schools to focus more on the E in STEM, to help students learn the skills and practices of engineering. Schools that are doing so face a challenge, however: How to design educational experiences in engineering that engage all students--including girls and minorities, who are…

  12. Make Room for Engineering

    ERIC Educational Resources Information Center

    Boesdorfer, Sarah; Greenhalgh, Scott

    2014-01-01

    The "Next Generation Science Standards" (NGSS Lead States 2013) urge science teachers to include engineering practices and ideas in their already full science curriculum, but many teachers do not know where to start. Only 7% of high school science teachers report feeling "very well prepared" to teach engineering. The…

  13. Teaching Engineering Practices

    ERIC Educational Resources Information Center

    Cunningham, Christine M.; Carlsen, William S.

    2014-01-01

    Engineering is featured prominently in the Next Generation Science Standards (NGSS) and related reform documents, but how its nature and methods are described is problematic. This paper is a systematic review and critique of that representation, and proposes that the disciplinary core ideas of engineering (as described in the NGSS) can be…

  14. Free piston stirling engines

    SciTech Connect

    Walker, C.

    1985-01-01

    This book presents a basic introduction to free piston Stirling engine technology through a review of specialized background material. It also includes information based on actual construction and operation experience with these machines, as well as theoretical and analytical insights into free piston Stirling engine technology.

  15. SCSE organic Rankine engine

    SciTech Connect

    Boda, F.P.

    1981-01-01

    The Organic Rankine Cycle (ORC) engine is described which has been developed by FACC for the Small Community Solar Thermal Power Experiment (SCSE). This engine is part of a Power Conversion Subsystem (PCS) located at the focal plant of a sun-tracking parabolic dish concentrator.

  16. Mathematical Education of Engineers.

    ERIC Educational Resources Information Center

    Organisation for Economic Cooperation and Development, Paris (France).

    The seminar reported in this document examined the university mathematics courses which should be available to future engineers, and was especially concerned with the introduction of computer science education. There are four major sections. The first reports a survey of electrical engineers in the United Kingdom which investigated how often they…

  17. Engine monitoring display study

    NASA Technical Reports Server (NTRS)

    Hornsby, Mary E.

    1992-01-01

    The current study is part of a larger NASA effort to develop displays for an engine-monitoring system to enable the crew to monitor engine parameter trends more effectively. The objective was to evaluate the operational utility of adding three types of information to the basic Boeing Engine Indicating and Crew Alerting System (EICAS) display formats: alphanumeric alerting messages for engine parameters whose values exceed caution or warning limits; alphanumeric messages to monitor engine parameters that deviate from expected values; and a graphic depiction of the range of expected values for current conditions. Ten training and line pilots each flew 15 simulated flight scenarios with five variants of the basic EICAS format; these variants included different combinations of the added information. The pilots detected engine problems more quickly when engine alerting messages were included in the display; adding a graphic depiction of the range of expected values did not affect detection speed. The pilots rated both types of alphanumeric messages (alert and monitor parameter) as more useful and easier to interpret than the graphic depiction. Integrating engine parameter messages into the EICAS alerting system appears to be both useful and preferred.

  18. Diesel Engine Mechanics.

    ERIC Educational Resources Information Center

    Foutes, William A.

    Written in student performance terms, this curriculum guide on diesel engine repair is divided into the following eight sections: an orientation to the occupational field and instructional program; instruction in operating principles; instruction in engine components; instruction in auxiliary systems; instruction in fuel systems; instruction in…

  19. Diesel engine exhaust oxidizer

    SciTech Connect

    Kammel, R.A.

    1992-06-16

    This patent describes a diesel engine exhaust oxidizing device. It comprises: an enclosure having an inlet for receiving diesel engine exhaust, a main flow path through the enclosure to an outlet of the enclosure, a by-ass through the enclosure, and a microprocessor control means.

  20. Think Engineer, Think Male?

    ERIC Educational Resources Information Center

    Male, Sally A.; Bush, Mark B.; Murray, Kevin

    2009-01-01

    Engineering education needs to develop the competencies required for engineering work, and attract and retain students from diverse backgrounds. This study investigated the possibility that the perceived importance of competencies is subconsciously influenced by gendered assumptions, and as a consequence, this lowers the status given to…

  1. Thermoacoustic engines and refrigerators

    NASA Astrophysics Data System (ADS)

    Garrett, Steven L.

    2012-06-01

    Thermoacoustic engines and refrigerators use gas inertia and compressibility to eliminate many of the mechanical contrivances required by traditional engines and refrigerators while providing potentially attractive options that might reduce environmental impacts. The operation of both standing-wave and traveling-wave devices will be described and illustrated with thermoacoustic devices that have been used outside the laboratory.

  2. The WSRC Engineering Analyzer

    SciTech Connect

    Beckmeyer, R.R.; Buckner, M.R.

    1992-01-01

    This report describes a multi-platform, multi-program engineering analysis tool that runs in either real-time or post-process modes, providing the analyst with a consistent, adaptable interface for 2-d color animation of time-oriented engineering data on any X-terminal.

  3. Concurrent Software Engineering Project

    ERIC Educational Resources Information Center

    Stankovic, Nenad; Tillo, Tammam

    2009-01-01

    Concurrent engineering or overlapping activities is a business strategy for schedule compression on large development projects. Design parameters and tasks from every aspect of a product's development process and their interdependencies are overlapped and worked on in parallel. Concurrent engineering suffers from negative effects such as excessive…

  4. First-Grade Engineers

    ERIC Educational Resources Information Center

    Bautista, Nazan Uludag; Peters, Kari Nichole

    2010-01-01

    Can students build a house that is cost effective and strong enough to survive strong winds, heavy rains, and earthquakes? First graders in Ms. Peter's classroom worked like engineers to answer this question. They participated in a design challenge that required them to plan like engineers and build strong and cost-effective houses that would fit…

  5. Engineering Technology Curriculum Guidelines

    ERIC Educational Resources Information Center

    Gershon, J. J.

    1977-01-01

    Summarizes curriculum guidelines for the following engineering technologies: chemical, industrial, mining, petroleum, nuclear, civil, mechanical, electrical, automotive, and manufacturing. In a few years, these Engineering Council for Professional Development committee guidelines are intended to become the criteria by which programs will be judged…

  6. Stirling engine piston ring

    DOEpatents

    Howarth, Roy B.

    1983-01-01

    A piston ring design for a Stirling engine wherein the contact pressure between the piston and the cylinder is maintained at a uniform level, independent of engine conditions through a balancing of the pressure exerted upon the ring's surface and thereby allowing the contact pressure on the ring to be predetermined through the use of a preloaded expander ring.

  7. Electronics Engineering Technology Curriculum.

    ERIC Educational Resources Information Center

    Georgia State Univ., Atlanta. Dept. of Vocational and Career Development.

    This guide offers information and procedures necessary to train electronics engineering technicians. Discussed first are the rationale and objectives of the curriculum. The occupational field of electronics engineering technology is described. Next, a curriculum model is set forth that contains information on the standard electronics engineering…

  8. Holographic heat engines

    NASA Astrophysics Data System (ADS)

    Johnson, Clifford V.

    2014-10-01

    It is shown that in theories of gravity where the cosmological constant is considered a thermodynamic variable, it is natural to use black holes as heat engines. Two examples are presented in detail using AdS charged black holes as the working substance. We notice that for static black holes, the maximally efficient traditional Carnot engine is also a Stirling engine. The case of negative cosmological constant supplies a natural realization of these engines in terms of the field theory description of the fluids to which they are holographically dual. We first propose a precise picture of how the traditional thermodynamic dictionary of holography is extended when the cosmological constant is dynamical and then conjecture that the engine cycles can be performed by using renormalization group flow. We speculate about the existence of a natural dual field theory counterpart to the gravitational thermodynamic volume.

  9. Thermoacoustic engines and refrigerators

    SciTech Connect

    Swift, G.

    1996-12-31

    This report is a transcript of a practice lecture given in preparation for a review lecture on the operation of thermoacoustic engines and refrigerators. The author begins by a brief review of the thermodynamic principles underlying the operation of thermoacoustic engines and refrigerators. Remember from thermodynamics class that there are two kinds of heat engines, the heat engine or the prime mover which produces work from heat, and the refrigerator or heat pump that uses work to pump heat. The device operates between two thermal reservoirs at temperatures T{sub hot} and T{sub cold}. In the heat engine, heat flows into the device from the reservoir at T{sub hot}, produces work, and delivers waste heat into the reservoir at T{sub cold}. In the refrigerator, work flows into the device, lifting heat Q{sub cold} from reservoir at T{sub cold} and rejecting waste heat into the reservoir at T{sub hot}.

  10. Metabolic Engineering VII Conference

    SciTech Connect

    Kevin Korpics

    2012-12-04

    The aims of this Metabolic Engineering conference are to provide a forum for academic and industrial researchers in the field; to bring together the different scientific disciplines that contribute to the design, analysis and optimization of metabolic pathways; and to explore the role of Metabolic Engineering in the areas of health and sustainability. Presentations, both written and oral, panel discussions, and workshops will focus on both applications and techniques used for pathway engineering. Various applications including bioenergy, industrial chemicals and materials, drug targets, health, agriculture, and nutrition will be discussed. Workshops focused on technology development for mathematical and experimental techniques important for metabolic engineering applications will be held for more in depth discussion. This 2008 meeting will celebrate our conference tradition of high quality and relevance to both industrial and academic participants, with topics ranging from the frontiers of fundamental science to the practical aspects of metabolic engineering.

  11. Aircraft engine pollution reduction.

    NASA Technical Reports Server (NTRS)

    Rudey, R. A.

    1972-01-01

    The effect of engine operation on the types and levels of the major aircraft engine pollutants is described and the major factors governing the formation of these pollutants during the burning of hydrocarbon fuel are discussed. Methods which are being explored to reduce these pollutants are discussed and their application to several experimental research programs are pointed out. Results showing significant reductions in the levels of carbon monoxide, unburned hydrocarbons, and oxides of nitrogen obtained from experimental combustion research programs are presented and discussed to point out potential application to aircraft engines. An experimental program designed to develop and demonstrate these and other advanced, low pollution combustor design methods is described. Results that have been obtained to date indicate considerable promise for reducing advanced engine exhaust pollutants to levels significantly below current engines.

  12. Aircraft Engine Systems

    NASA Technical Reports Server (NTRS)

    Veres, Joseph

    2001-01-01

    This report outlines the detailed simulation of Aircraft Turbofan Engine. The objectives were to develop a detailed flow model of a full turbofan engine that runs on parallel workstation clusters overnight and to develop an integrated system of codes for combustor design and analysis to enable significant reduction in design time and cost. The model will initially simulate the 3-D flow in the primary flow path including the flow and chemistry in the combustor, and ultimately result in a multidisciplinary model of the engine. The overnight 3-D simulation capability of the primary flow path in a complete engine will enable significant reduction in the design and development time of gas turbine engines. In addition, the NPSS (Numerical Propulsion System Simulation) multidisciplinary integration and analysis are discussed.

  13. Engineered cardiac tissues

    PubMed Central

    Iyer, Rohin K.; Chiu, Loraine L. Y.; Reis, Lewis A.; Radisic, Milica

    2011-01-01

    Cardiac tissue engineering offers the promise of creating functional tissue replacements for use in the failing heart or for in vitro drug screening. The last decade has seen a great deal of progress in this field with new advances in interdisciplinary areas such as developmental biology, genetic engineering, biomaterials, polymer science, bioreactor engineering, and stem cell biology. We review here a selection of the most recent advances in cardiac tissue engineering, including the classical cell-scaffold approaches, advanced bioreactor designs, cell sheet engineering, whole organ decellularization, stem-cell based approaches, and topographical control of tissue organization and function. We also discuss current challenges in the field, such as maturation of stem cell-derived cardiac patches and vascularization. PMID:21530228

  14. Mod II engine performance

    NASA Technical Reports Server (NTRS)

    Richey, Albert E.; Huang, Shyan-Cherng

    1987-01-01

    The testing of a prototype of an automotive Stirling engine, the Mod II, is discussed. The Mod II is a one-piece cast block with a V-4 single-crankshaft configuration and an annular regenerator/cooler design. The initial testing of Mod II concentrated on the basic engine, with auxiliaries driven by power sources external to the engine. The performance of the engine was tested at 720 C set temperature and 820 C tube temperature. At 720 C, it is observed that the power deficiency is speed dependent and linear, with a weak pressure dependency, and at 820 C, the power deficiency is speed and pressure dependent. The effects of buoyancy and nozzle spray pattern on the heater temperature spread are investigated. The characterization of the oil pump and the operating cycle and temperature spread tests are proposed for further evaluation of the engine.

  15. Systems engineering management plans.

    SciTech Connect

    Rodriguez, Tamara S.

    2009-10-01

    The Systems Engineering Management Plan (SEMP) is a comprehensive and effective tool used to assist in the management of systems engineering efforts. It is intended to guide the work of all those involved in the project. The SEMP is comprised of three main sections: technical project planning and control, systems engineering process, and engineering specialty integration. The contents of each section must be tailored to the specific effort. A model outline and example SEMP are provided. The target audience is those who are familiar with the systems engineering approach and who have an interest in employing the SEMP as a tool for systems management. The goal of this document is to provide the reader with an appreciation for the use and importance of the SEMP, as well as provide a framework that can be used to create the management plan.

  16. Adaptive Heat Engine

    NASA Astrophysics Data System (ADS)

    Allahverdyan, A. E.; Babajanyan, S. G.; Martirosyan, N. H.; Melkikh, A. V.

    2016-07-01

    A major limitation of many heat engines is that their functioning demands on-line control and/or an external fitting between the environmental parameters (e.g., temperatures of thermal baths) and internal parameters of the engine. We study a model for an adaptive heat engine, where—due to feedback from the functional part—the engine's structure adapts to given thermal baths. Hence, no on-line control and no external fitting are needed. The engine can employ unknown resources; it can also adapt to results of its own functioning that make the bath temperatures closer. We determine resources of adaptation and relate them to the prior information available about the environment.

  17. Elements of Engineering Excellence

    NASA Technical Reports Server (NTRS)

    Blair, J. C.; Ryan, R. S.; Schutzenhofer

    2012-01-01

    The inspiration for this Contract Report (CR) originated in discussions with the director of Marshall Space Flight Center (MSFC) Engineering who asked that we investigate the question: "How do you achieve excellence in aerospace engineering?" Engineering a space system is a complex activity. Avoiding its inherent potential pitfalls and achieving a successful product is a challenge. This CR presents one approach to answering the question of how to achieve Engineering Excellence. We first investigated the root causes of NASA major failures as a basis for developing a proposed answer to the question of Excellence. The following discussions integrate a triad of Technical Understanding and Execution, Partnership with the Project, and Individual and Organizational Culture. The thesis is that you must focus on the whole process and its underlying culture, not just on the technical aspects. In addition to the engineering process, emphasis is given to the need and characteristics of a Learning Organization as a mechanism for changing the culture.

  18. Adaptive Heat Engine.

    PubMed

    Allahverdyan, A E; Babajanyan, S G; Martirosyan, N H; Melkikh, A V

    2016-07-15

    A major limitation of many heat engines is that their functioning demands on-line control and/or an external fitting between the environmental parameters (e.g., temperatures of thermal baths) and internal parameters of the engine. We study a model for an adaptive heat engine, where-due to feedback from the functional part-the engine's structure adapts to given thermal baths. Hence, no on-line control and no external fitting are needed. The engine can employ unknown resources; it can also adapt to results of its own functioning that make the bath temperatures closer. We determine resources of adaptation and relate them to the prior information available about the environment. PMID:27472104

  19. Engineering Complex Tissues

    PubMed Central

    MIKOS, ANTONIOS G.; HERRING, SUSAN W.; OCHAREON, PANNEE; ELISSEEFF, JENNIFER; LU, HELEN H.; KANDEL, RITA; SCHOEN, FREDERICK J.; TONER, MEHMET; MOONEY, DAVID; ATALA, ANTHONY; VAN DYKE, MARK E.; KAPLAN, DAVID; VUNJAK-NOVAKOVIC, GORDANA

    2010-01-01

    This article summarizes the views expressed at the third session of the workshop “Tissue Engineering—The Next Generation,” which was devoted to the engineering of complex tissue structures. Antonios Mikos described the engineering of complex oral and craniofacial tissues as a “guided interplay” between biomaterial scaffolds, growth factors, and local cell populations toward the restoration of the original architecture and function of complex tissues. Susan Herring, reviewing osteogenesis and vasculogenesis, explained that the vascular arrangement precedes and dictates the architecture of the new bone, and proposed that engineering of osseous tissues might benefit from preconstruction of an appropriate vasculature. Jennifer Elisseeff explored the formation of complex tissue structures based on the example of stratified cartilage engineered using stem cells and hydrogels. Helen Lu discussed engineering of tissue interfaces, a problem critical for biological fixation of tendons and ligaments, and the development of a new generation of fixation devices. Rita Kandel discussed the challenges related to the re-creation of the cartilage-bone interface, in the context of tissue engineered joint repair. Frederick Schoen emphasized, in the context of heart valve engineering, the need for including the requirements derived from “adult biology” of tissue remodeling and establishing reliable early predictors of success or failure of tissue engineered implants. Mehmet Toner presented a review of biopreservation techniques and stressed that a new breakthrough in this field may be necessary to meet all the needs of tissue engineering. David Mooney described systems providing temporal and spatial regulation of growth factor availability, which may find utility in virtually all tissue engineering and regeneration applications, including directed in vitro and in vivo vascularization of tissues. Anthony Atala offered a clinician’s perspective for functional tissue

  20. 19. Engine identified as a single cylinder vacuum assist engine ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. Engine identified as a single cylinder vacuum assist engine for the Filer and Stowell 15-inch continuous mill. - Carnegie Steel-Ohio Works, Steam Engines, 912 Salt Springs Road, Youngstown, Mahoning County, OH

  1. 5. Engine room, general view looking east, engine #2 in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Engine room, general view looking east, engine #2 in foreground (1895, now cannibalized for parts), engine #3 is in the background - East Boston Pumping Station, Chelsea Street at Chelsea Creek, Boston, Suffolk County, MA

  2. 1. EXTERIOR OF ENGINE ROOM, CONTAINING UNITEDTOD TWINTANDEM ENGINE, FOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EXTERIOR OF ENGINE ROOM, CONTAINING UNITED-TOD TWIN-TANDEM ENGINE, FOR 40" BLOOMING MILL - Republic Iron & Steel Company, Youngstown Works, Blooming Mill & Blooming Mill Engines, North of Poland Avenue, Youngstown, Mahoning County, OH

  3. 2. EXTERIOR OF ENGINE ROOM, CONTAINING MESTACORLISS CROSSCOMPOUND ENGINE, FOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. EXTERIOR OF ENGINE ROOM, CONTAINING MESTA-CORLISS CROSS-COMPOUND ENGINE, FOR 40" BLOOMING MILL - Republic Iron & Steel Company, Youngstown Works, Blooming Mill & Blooming Mill Engines, North of Poland Avenue, Youngstown, Mahoning County, OH

  4. Technician Career Opportunities in Engineering Technology.

    ERIC Educational Resources Information Center

    Engineers' Council for Professional Development, New York, NY.

    Career opportunities for engineering technicians are available in the technologies relating to air conditioning, heating, and refrigeration, aviation and aerospace, building construction, chemical engineering, civil engineering, electrical engineering, electronics, industrial engineering, instrumentation, internal combustion engines, mechanical…

  5. E85 Optimized Engine

    SciTech Connect

    Bower, Stanley

    2011-12-31

    A 5.0L V8 twin-turbocharged direct injection engine was designed, built, and tested for the purpose of assessing the fuel economy and performance in the F-Series pickup of the Dual Fuel engine concept and of an E85 optimized FFV engine. Additionally, production 3.5L gasoline turbocharged direct injection (GTDI) EcoBoost engines were converted to Dual Fuel capability and used to evaluate the cold start emissions and fuel system robustness of the Dual Fuel engine concept. Project objectives were: to develop a roadmap to demonstrate a minimized fuel economy penalty for an F-Series FFV truck with a highly boosted, high compression ratio spark ignition engine optimized to run with ethanol fuel blends up to E85; to reduce FTP 75 energy consumption by 15% - 20% compared to an equally powered vehicle with a current production gasoline engine; and to meet ULEV emissions, with a stretch target of ULEV II / Tier II Bin 4. All project objectives were met or exceeded.

  6. Developing Data System Engineers

    NASA Astrophysics Data System (ADS)

    Behnke, J.; Byrnes, J. B.; Kobler, B.

    2011-12-01

    In the early days of general computer systems for science data processing, staff members working on NASA's data systems would most often be hired as mathematicians. Computer engineering was very often filled by those with electrical engineering degrees. Today, the Goddard Space Flight Center has special position descriptions for data scientists or as they are more commonly called: data systems engineers. These staff members are required to have very diverse skills, hence the need for a generalized position description. There is always a need for data systems engineers to develop, maintain and operate the complex data systems for Earth and space science missions. Today's data systems engineers however are not just mathematicians, they are computer programmers, GIS experts, software engineers, visualization experts, etc... They represent many different degree fields. To put together distributed systems like the NASA Earth Observing Data and Information System (EOSDIS), staff are required from many different fields. Sometimes, the skilled professional is not available and must be developed in-house. This paper will address the various skills and jobs for data systems engineers at NASA. Further it explores how to develop staff to become data scientists.

  7. Heavy Truck Engine Program

    SciTech Connect

    Nelson, Christopher

    2009-01-08

    The Heavy Duty Truck Engine Program at Cummins embodied three significant development phases. All phases of work strove to demonstrate a high level of diesel engine efficiency in the face of increasingly stringent emission requirements. Concurrently, aftertreatment system development and refinement was pursued in support of these efficiency demonstrations. The program's first phase focused on the demonstration in-vehicle of a high level of heavy duty diesel engine efficiency (45% Brake Thermal Efficiency) at a typical cruise condition while achieving composite emissions results which met the 2004 U.S. EPA legislated standards. With a combination of engine combustion calibration tuning and the development and application of Urea-based SCR and particulate aftertreatment, these demonstrations were successfully performed by Q4 of 2002. The second phase of the program directed efforts towards an in-vehicle demonstration of an engine system capable of meeting 2007 U.S. EPA legislated emissions requirements while achieving 45% Brake Thermal Efficiency at cruise conditions. Through further combustion optimization, the refinement of Cummins Cooled EGR architecture, the application of a high pressure common rail fuel system and the incorporation of optimized engine parasitics, Cummins Inc. successfully demonstrated these deliverables in Q2 of 2004. The program's final phase set a stretch goal of demonstrating 50% Brake Thermal Efficiency from a heavy duty diesel engine system capable of meeting 2010 U.S. EPA legislated emissions requirements. Cummins chose to pursue this goal through further combustion development and refinement of the Cooled EGR system architecture and also applied a Rankine cycle Waste Heat Recovery technique to convert otherwise wasted thermal energy to useful power. The engine and heat recovery system was demonstrated to achieve 50% Brake Thermal Efficiency while operating at a torque peak condition in second quarter, 2006. The 50% efficient engine

  8. Philosophical Foundations of Biological Engineering.

    ERIC Educational Resources Information Center

    Johnson, Arthur T.; Phillips, Winfred M.

    1995-01-01

    Discusses a philosophy from which biological engineering curriculums can emerge. Discusses competencies, basic engineering and biological concepts, common courses, interfacing between engineers and biologists, and employment. Contains 28 references. (JRH)

  9. New Directions for Biomedical Engineering

    ERIC Educational Resources Information Center

    Plonsey, Robert

    1973-01-01

    Discusses the definition of "biomedical engineering" and the development of educational programs in the field. Includes detailed descriptions of the roles of bioengineers, medical engineers, and chemical engineers. (CC)

  10. Engineering the LISA Project: Systems Engineering Challenges

    NASA Technical Reports Server (NTRS)

    Evans, Jordan P.

    2006-01-01

    The Laser Interferometer Space Antenna (LISA) is a joint NASA/ESA mission to detect and measure gravitational waves with periods from 1 s to 10000 s. The systems engineering challenges of developing a giant interferometer, 5 million kilometers on a side, an: numerous. Some of the key challenges are presented in this paper. The organizational challenges imposed by sharing the engineering function between three centers (ESA ESTEC, NASA GSFC, and JPL) across nine time zones are addressed. The issues and approaches to allocation of the acceleration noise and measurement sensitivity budget terms across a traditionally decomposed system are discussed. Additionally, using LISA to detect gravitational waves for the first time presents significant data analysis challenges, many of which drive the project system design. The approach to understanding the implications of science data analysis on the system is also addressed.

  11. CSM petroleum Engineering Department

    SciTech Connect

    Van Kirk, C.

    1984-10-01

    The Petroleum Engineering (PE) Department at the Colorado School of Mines is the second oldest such engineering department in the world, having been founded in 1918, one year after the program at Penn State University was begun. The PE Department at CSM has enjoyed a strong worldwide reputation from its earliest beginnings to the present time. The discipline of petroleum engineering is taught in only a few universities, generally in American oil producing states and foreign countries having significant interests in petroleum. Approximately 25 US universities offer degrees in PE, while an equal number of universities in foreign countries do so. The operation of the Department is discussed.

  12. Advanced engine study program

    NASA Technical Reports Server (NTRS)

    Masters, A. I.; Galler, D. E.; Denman, T. F.; Shied, R. A.; Black, J. R.; Fierstein, A. R.; Clark, G. L.; Branstrom, B. R.

    1993-01-01

    A design and analysis study was conducted to provide advanced engine descriptions and parametric data for space transfer vehicles. The study was based on an advanced oxygen/hydrogen engine in the 7,500 to 50,000 lbf thrust range. Emphasis was placed on defining requirements for high-performance engines capable of achieving reliable and versatile operation in a space environment. Four variations on the expander cycle were compared, and the advantages and disadvantages of each were assessed. Parametric weight, envelope, and performance data were generated over a range of 7,500 to 50,000 lb thrust and a wide range of chamber pressure and nozzle expansion ratio.

  13. Model Driven Engineering

    NASA Astrophysics Data System (ADS)

    Gaševic, Dragan; Djuric, Dragan; Devedžic, Vladan

    A relevant initiative from the software engineering community called Model Driven Engineering (MDE) is being developed in parallel with the Semantic Web (Mellor et al. 2003a). The MDE approach to software development suggests that one should first develop a model of the system under study, which is then transformed into the real thing (i.e., an executable software entity). The most important research initiative in this area is the Model Driven Architecture (MDA), which is Model Driven Architecture being developed under the umbrella of the Object Management Group (OMG). This chapter describes the basic concepts of this software engineering effort.

  14. Test pilot and engineer

    NASA Technical Reports Server (NTRS)

    1922-01-01

    Goggles at the ready, this Langley test pilot and engineer conducted research business high above the ground. Photograph published in Winds of Change, 75th Anniversary NASA publication, by James Schultz (page 24). This photograph is also published in Engineer in Charge: A History of the Langley Aeronautical Laboratory, 1917-1958 by James R. Hansen (page 163). In the early years the flight research team was usually made up of a test pilot (Thomas Carroll, front cockpit) and an engineer (John W. Gus Crowley,Jr.).

  15. Nuclear propulsion systems engineering

    SciTech Connect

    Madsen, W.W.; Neuman, J.E.: Van Haaften, D.H.

    1992-12-31

    The Nuclear Energy for Rocket Vehicle Application (NERVA) program of the 1960`s and early 1970`s was dramatically successful, with no major failures during the entire testing program. This success was due in large part to the successful development of a systems engineering process. Systems engineering, properly implemented, involves all aspects of the system design and operation, and leads to optimization of theentire system: cost, schedule, performance, safety, reliability, function, requirements, etc. The process must be incorporated from the very first and continued to project completion. This paper will discuss major aspects of the NERVA systems engineering effort, and consider the implications for current nuclear propulsion efforts.

  16. Nuclear propulsion systems engineering

    SciTech Connect

    Madsen, W.W.; Neuman, J.E.: Van Haaften, D.H.

    1992-01-01

    The Nuclear Energy for Rocket Vehicle Application (NERVA) program of the 1960's and early 1970's was dramatically successful, with no major failures during the entire testing program. This success was due in large part to the successful development of a systems engineering process. Systems engineering, properly implemented, involves all aspects of the system design and operation, and leads to optimization of theentire system: cost, schedule, performance, safety, reliability, function, requirements, etc. The process must be incorporated from the very first and continued to project completion. This paper will discuss major aspects of the NERVA systems engineering effort, and consider the implications for current nuclear propulsion efforts.

  17. Turbo compound engine

    SciTech Connect

    Okada, M.; Sekiyama, S.

    1988-06-07

    A turbo compound engine is described comprising: an engine having an exhaust gas passage and a crankshaft; a power turbine disposed in the exhaust gas passage so as to recover the exhaust gas energy; driving power transmission means for drivingly connecting the power turbine and the crankshaft so as to transmit the driving power; a fluid passage connected to a portion of the exhaust passage which lies between the power turbine and the engine; and fluid passage switching means for closing the exhaust passage upstream of the fluid passage while opening the fluid passage during exhaust braking.

  18. Aircraft engine pollution reduction

    NASA Technical Reports Server (NTRS)

    Rudey, R. A.

    1972-01-01

    The effect of engine operation on the types and levels of the major aircraft engine pollutants is described and the major factors governing the formation of these pollutants during the burning of hydrocarbon fuel are discussed. Methods which are being explored to reduce these pollutants are discussed and their application to several experimental research programs are pointed out. Results showing significant reductions in the levels of carbon monoxide, unburned hydrocarbons, and oxides of nitrogen obtained from experimental combustion research programs are presented and discussed to point out potential application to aircraft engines.

  19. Aircraft engines. II

    SciTech Connect

    Smith, M.G. Jr.

    1988-01-01

    An account is given of the design features and prospective performance gains of ultrahigh bypass subsonic propulsion configurations and various candidate supersonic commercial aircraft powerplants. The supersonic types, whose enhanced thermodynamic cycle efficiency is considered critical to the economic viability of a second-generation SST, are the variable-cycle engine, the variable stream control engine, the turbine-bypass engine, and the supersonic-throughflow fan. Also noted is the turboramjet concept, which will be applicable to hypersonic aircraft whose airframe structure materials can withstand the severe aerothermodynamic conditions of this flight regime.

  20. Improving Search Engine Reliability

    NASA Astrophysics Data System (ADS)

    Pruthi, Jyoti; Kumar, Ela

    2010-11-01

    Search engines on the Internet are used daily to access and find information. While these services are providing an easy way to find information globally, they are also suffering from artificially created false results. This paper describes two techniques that are being used to manipulate the search engines: spam pages (used to achieve higher rankings on the result page) and cloaking (used to feed falsified data into search engines). This paper also describes two proposed methods to fight this kind of misuse, algorithms for both of the formerly mentioned cases of spamdexing.

  1. Principles of models based engineering

    SciTech Connect

    Dolin, R.M.; Hefele, J.

    1996-11-01

    This report describes a Models Based Engineering (MBE) philosophy and implementation strategy that has been developed at Los Alamos National Laboratory`s Center for Advanced Engineering Technology. A major theme in this discussion is that models based engineering is an information management technology enabling the development of information driven engineering. Unlike other information management technologies, models based engineering encompasses the breadth of engineering information, from design intent through product definition to consumer application.

  2. Automotive Stirling Engine Development Program

    NASA Technical Reports Server (NTRS)

    Nightingale, N.; Ernst, W.; Richey, A.; Simetkosky, M.; Smith, G.; Antonelli, M. (Editor)

    1983-01-01

    Mod I engine testing and test results, the test of a Mod I engine in the United States, Mod I engine characterization and analysis, Mod I Transient Test Bed fuel economy, Mod I-A engine performance are discussed. Stirling engine reference engine manufacturing and reduced size studies, components and subsystems, and the study and test of low-cost casting alloys are also covered. The overall program philosophy is outlined, and data and results are presented.

  3. Stennis certifies final shuttle engine

    NASA Technical Reports Server (NTRS)

    2008-01-01

    Steam blasts out of the A-2 Test Stand at Stennis Space Center on Oct. 22 as engineers begin a certification test on engine 2061, the last space shuttle main flight engine scheduled to be built. Since 1975, Stennis has tested every space shuttle main engine used in the program - about 50 engines in all. Those engines have powered more than 120 shuttle missions - and no mission has failed as a result of engine malfunction. For the remainder of 2008 and throughout 2009, Stennis will continue testing of various space shuttle main engine components.

  4. PROFESSIONAL REGISTRATION OF GOVERNMENT ENGINEERS.

    USGS Publications Warehouse

    Buchanan, Thomas J.

    1985-01-01

    The American Society of Civil Engineers views professional registration as an appropriate requirement for engineers, including those in government. The National Society of Professional Engineers makes registration a requirement for the grade of member and full privileges in the society. Some Federal agencies require engineering registration for certain positions in their agencies. Engineers in government service should consider the value of engineering registration to themselves and to their agencies and take pride in their professions and in their own capabilities by becoming registered engineers. They should also take steps to encourage their agencies to give more attention to engineering registration.

  5. Wave rotor demonstrator engine assessment

    NASA Technical Reports Server (NTRS)

    Snyder, Philip H.

    1996-01-01

    The objective of the program was to determine a wave rotor demonstrator engine concept using the Allison 250 series engine. The results of the NASA LERC wave rotor effort were used as a basis for the wave rotor design. A wave rotor topped gas turbine engine was identified which incorporates five basic requirements of a successful demonstrator engine. Predicted performance maps of the wave rotor cycle were used along with maps of existing gas turbine hardware in a design point study. The effects of wave rotor topping on the engine cycle and the subsequent need to rematch compressor and turbine sections in the topped engine were addressed. Comparison of performance of the resulting engine is made on the basis of wave rotor topped engine versus an appropriate baseline engine using common shaft compressor hardware. The topped engine design clearly demonstrates an impressive improvement in shaft horsepower (+11.4%) and SFC (-22%). Off design part power engine performance for the wave rotor topped engine was similarly improved including that at engine idle conditions. Operation of the engine at off design was closely examined with wave rotor operation at less than design burner outlet temperatures and rotor speeds. Challenges identified in the development of a demonstrator engine are discussed. A preliminary design was made of the demonstrator engine including wave rotor to engine transition ducts. Program cost and schedule for a wave rotor demonstrator engine fabrication and test program were developed.

  6. Turbo compound engine

    SciTech Connect

    Kawamura, H.

    1988-05-24

    A turbo compound engine having a first exhaust turbine coupled to an exhaust pipe of an internal combustion engine and a second exhaust turbine coupled to an exhaust port of the first exhaust turbine is described comprising: a first generator drivable by the first exhaust turbine; a second generator drivable by the second exhaust turbine; a motor operatively coupled to an output shaft of the internal combustion engine; speed detecting means for detecting the speed of rotation of the internal combustion engine; and control means for controlling the frequency of electric power, which is the sum of electric power outputs from the first and second generators and supplied to the motor, based on a signal from the speed detecting means, in order to control operation of the motor.

  7. Engine speed control apparatus

    SciTech Connect

    Ishii, M.; Miyazaki, M.; Nakamura, N.; Kakinuma, H.

    1986-11-04

    This patent describes an engine speed control apparatus. The system comprises an actuator for adjusting an engine speed, a first unit for computing a desired engine speed, a second unit for detecting the actual engine speed, and a third unit for detecting the difference between the outputs of the first and second units. The system also includes a fourth unit for computing a control pulse width for the actuator in accordance with the output of the third unit, a fifth unit for generating a control signal, a sixth unit for driving the actuator in response to the output of the fifth unit, and a seventh unit for computing an optimal halt time to interrupt the driving of the actuator. The actuator is driven intermittently in conformity in the control pulse width and the halt time.

  8. J-2 Engine Test

    NASA Technical Reports Server (NTRS)

    1963-01-01

    Smokeless flame juts from the diffuser of a unique vacuum chamber in which the upper stage rocket engine, the hydrogen fueled J-2, was tested at a simulated space altitude in excess of 60,000 feet. The smoke you see is actually steam. In operation, vacuum is established by injecting steam into the chamber and is maintained by the thrust of the engine firing through the diffuser. The engine was tested in this environment for start, stop, coast, restart, and full-duration operations. The chamber was located at Rocketdyne's Propulsion Field Laboratory, in the Santa Susana Mountains, near Canoga Park, California. The J-2 engine was developed by Rocketdyne for the Marshall Space Flight Center.

  9. NASA Now: Engineering Spacesuits

    NASA Video Gallery

    Mallory Jennings, a Technology Development Engineer who develops components for the next-generation spacesuit, explains how the design for the spacesuit is dependent upon the mission that the astro...

  10. A sublimation heat engine

    NASA Astrophysics Data System (ADS)

    Wells, Gary G.; Ledesma-Aguilar, Rodrigo; McHale, Glen; Sefiane, Khellil

    2015-03-01

    Heat engines are based on the physical realization of a thermodynamic cycle, most famously the liquid-vapour Rankine cycle used for steam engines. Here we present a sublimation heat engine, which can convert temperature differences into mechanical work via the Leidenfrost effect. Through controlled experiments, quantified by a hydrodynamic model, we show that levitating dry-ice blocks rotate on hot turbine-like surfaces at a rate controlled by the turbine geometry, temperature difference and solid material properties. The rotational motion of the dry-ice loads is converted into electric power by coupling to a magnetic coil system. We extend our concept to liquid loads, generalizing the realization of the new engine to both sublimation and the instantaneous vapourization of liquids. Our results support the feasibility of low-friction in situ energy harvesting from both liquids and ices. Our concept is potentially relevant in challenging situations such as deep drilling, outer space exploration or micro-mechanical manipulation.

  11. Rocket engine numerical simulation

    NASA Technical Reports Server (NTRS)

    Davidian, Ken

    1993-01-01

    The topics are presented in view graph form and include the following: a definition of the rocket engine numerical simulator (RENS); objectives; justification; approach; potential applications; potential users; RENS work flowchart; RENS prototype; and conclusions.

  12. Continuous detonation reaction engine

    NASA Technical Reports Server (NTRS)

    Lange, O. H.; Stein, R. J.; Tubbs, H. E.

    1968-01-01

    Reaction engine operates on the principles of a controlled condensed detonation rather than on the principles of gas expansion. The detonation results in reaction products that are expelled at a much higher velocity.

  13. Web document engineering

    SciTech Connect

    White, B.

    1996-05-01

    This tutorial provides an overview of several document engineering techniques which are applicable to the authoring of World Wide Web documents. It illustrates how pre-WWW hypertext research is applicable to the development of WWW information resources.

  14. Robust Rocket Engine Concept

    NASA Technical Reports Server (NTRS)

    Lorenzo, Carl F.

    1995-01-01

    The potential for a revolutionary step in the durability of reusable rocket engines is made possible by the combination of several emerging technologies. The recent creation and analytical demonstration of life extending (or damage mitigating) control technology enables rapid rocket engine transients with minimum fatigue and creep damage. This technology has been further enhanced by the formulation of very simple but conservative continuum damage models. These new ideas when combined with recent advances in multidisciplinary optimization provide the potential for a large (revolutionary) step in reusable rocket engine durability. This concept has been named the robust rocket engine concept (RREC) and is the basic contribution of this paper. The concept also includes consideration of design innovations to minimize critical point damage.

  15. To Teach Chemists Engineering.

    ERIC Educational Resources Information Center

    Grinbaum, Baruch; Semiat, Raphael

    1998-01-01

    Cites the shortcomings of the traditional educational experiences of chemists. Focuses on their training in engineering and concludes that training is lacking in the areas of mass balances in flow processes, heat balances, reactors, separation processes, and scaleup. (DDR)

  16. Combustion engine system

    NASA Technical Reports Server (NTRS)

    Houseman, John (Inventor); Voecks, Gerald E. (Inventor)

    1986-01-01

    A flow through catalytic reactor which selectively catalytically decomposes methanol into a soot free hydrogen rich product gas utilizing engine exhaust at temperatures of 200 to 650 C to provide the heat for vaporizing and decomposing the methanol is described. The reactor is combined with either a spark ignited or compression ignited internal combustion engine or a gas turbine to provide a combustion engine system. The system may be fueled entirely by the hydrogen rich gas produced in the methanol decomposition reactor or the system may be operated on mixed fuels for transient power gain and for cold start of the engine system. The reactor includes a decomposition zone formed by a plurality of elongated cylinders which contain a body of vapor permeable, methanol decomposition catalyst preferably a shift catalyst such as copper-zinc.

  17. LIFE CYCLE ENGINEERING GUIDELINES

    EPA Science Inventory

    This document provides guidelines for the implementation of LCE concepts, information, and techniques in engineering products, systems, processes, and facilities. To make this document as practical and useable as possible, a unifying LCE framework is presented. Subsequent topics ...

  18. Hydrogen-fueled engine

    NASA Technical Reports Server (NTRS)

    Laumann, E. A.; Reynolds, R. K. (Inventor)

    1978-01-01

    A hydrogen-oxygen fueled internal combustion engine is described, which utilizes an inert gas, such as argon, as a working fluid to increase the efficiency of the engine, eliminate pollution, and facilitate operation of a closed cycle energy system. In a system where sunlight or other intermittent energy source is available to separate hydrogen and oxygen from water, the oxygen and inert gas are taken into a diesel engine into which hydrogen is injected and ignited. The exhaust is cooled so that it contains only water and the inert gas. The inert gas in the exhaust is returned to the engine for use with fresh oxygen, while the water in the exhaust is returned to the intermittent energy source for reconversion to hydrogen and oxygen.

  19. Engineering Capabilities and Partnerships

    NASA Technical Reports Server (NTRS)

    Poulos, Steve

    2010-01-01

    This slide presentation reviews the engineering capabilities at Johnson Space Center, The presentation also reviews the partnerships that have resulted in successfully designed and developed projects that involved commercial and educational institutions.

  20. Web Search Engines.

    ERIC Educational Resources Information Center

    Schwartz, Candy

    1998-01-01

    Looks briefly at the history of World Wide Web search engine development and considers the current state of affairs. Reflects on future directions in terms of personalization, summarization, query expansion, coverage, and metadata. (Author/AEF)