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Sample records for 2d fourier analysis

  1. Real-time 2D parallel windowed Fourier transform for fringe pattern analysis using Graphics Processing Unit.

    PubMed

    Gao, Wenjing; Huyen, Nguyen Thi Thanh; Loi, Ho Sy; Kemao, Qian

    2009-12-01

    In optical interferometers, fringe projection systems, and synthetic aperture radars, fringe patterns are common outcomes and usually degraded by unavoidable noises. The presence of noises makes the phase extraction and phase unwrapping challenging. Windowed Fourier transform (WFT) based algorithms have been proven to be effective for fringe pattern analysis to various applications. However, the WFT-based algorithms are computationally expensive, prohibiting them from real-time applications. In this paper, we propose a fast parallel WFT-based library using graphics processing units and computer unified device architecture. Real-time WFT-based algorithms are achieved with 4 frames per second in processing 256x256 fringe patterns. Up to 132x speedup is obtained for WFT-based algorithms using NVIDIA GTX295 graphics card than sequential C in quad-core 2.5GHz Intel(R)Xeon(R) CPU E5420. PMID:20052242

  2. Analysis of the High-Resolution Fourier Spectrum of the ν6 Band of the cis-C2h2d2 Molecule

    NASA Astrophysics Data System (ADS)

    Konov, I. A.; Chertavskikh, Yu. V.; Fomchenko, A. L.; Aslapovskaya, Yu. S.; Zhdanovich, S. A.; Sydow, C.

    2016-03-01

    The spectrum of the ν6 band of the cis-ethylene-d2 molecule (cis-C2H2D2) is recorded with a Bruker IFS 125 HR Fourier spectrometer in the range 580-1210 cm-1 with resolution of 0.0021 cm-1. An analysis of the experimental spectrum allows more than 1500 transitions belonging to this band to be assigned that by more than 2.5 times greater than it has been known in the literature so far. The obtained experimental data are then used to determine the model parameters of the molecule (the effective Hamiltonian in the A-reduction and I'- representation). Strong resonance interaction with the band ν4 forbidden in absorption by the symmetry of a molecule is taken into account. 10 parameters of the Hamiltonian obtained by solving inverse spectroscopic problem reproduce 427 initial experimental energies (more than 1500 transitions) with accuracy close to the experimental uncertainty.

  3. 2D Regimes of Non-Fourier Convection

    NASA Astrophysics Data System (ADS)

    Papanicolaou, N. C.

    2010-11-01

    In this work, we investigate the 2D flow in a rectangular cavity subject to both vertical and horizontal temperature gradients. The linearized model is studied and the effect of thermal relaxation, as described by the Maxwell-Cattaneo law of heat conduction is examined. To this end, a spectral numerical model is created based on a Galerkin expansion. The basis is the Cartesian product of systems of beam functions and trigonometric functions. The natural modes of the system are derived for both the Fourier and non-Fourier models. The results are compared to earlier works for the plain Fourier law. Our computations show that for the same set of parameters, the Maxwell-Cattaneo law yields modes which are quantitatively different from the Fourier. It is found that the real parts of the eigenvalues increase with the Straughan number Sg, which quantifies the non-Fourier effects. This confirms the destabilizing effect of the MC-law on the convective flow.

  4. Comparative Variable Temperature Studies of Polyamide II with a Benchtop Fourier Transform and a Miniature Handheld Near-Infrared Spectrometer Using 2D-COS and PCMW-2D Analysis.

    PubMed

    Unger, Miriam; Pfeifer, Frank; Siesler, Heinz W

    2016-07-01

    The main objective of this communication is to compare the performance of a miniaturized handheld near-infrared (NIR) spectrometer with a benchtop Fourier transform near-infrared (FT-NIR) spectrometer. Generally, NIR spectroscopy is an extremely powerful analytical tool to study hydrogen-bonding changes of amide functionalities in solid and liquid materials and therefore variable temperature NIR measurements of polyamide II (PAII) have been selected as a case study. The information content of the measurement data has been further enhanced by exploiting the potential of two-dimensional correlation spectroscopy (2D-COS) and the perturbation correlation moving window two-dimensional (PCMW2D) evaluation technique. The data provide valuable insights not only into the changes of the hydrogen-bonding structure and the recrystallization of the hydrocarbon segments of the investigated PAII but also in their sequential order. Furthermore, it has been demonstrated that the 2D-COS and PCMW2D results derived from the spectra measured with the miniaturized NIR instrument are equivalent to the information extracted from the data obtained with the high-performance FT-NIR instrument. PMID:27287846

  5. Fourier analysis

    SciTech Connect

    Lawson, J.

    1997-03-03

    What follows is a description of my analysis. First, the FFT that I use is described on the attached pages. Note that the scaling factor for the forward transform is 1/N. I compute the following rms values: rms(original data) = 64.9463 nm; rms(data*hanning) = 55.7723 nm (before renormalization). The use of the hanning filter is accompanied by a renormalization to insure that the rms value is maintained. I also fit to the curvature of the scan. The data corrected for focus gives the following rms values: rms(corrected data) = 56.8835 nm; rms(corrected data*hanning) = 53.2179 nm (before renormalization). The PSD is shown for various data. The PSD is calculated as: PSD = | FFT(y) | {sup 2} * xl where xl is the length of the x axis, 45.9952. I did find an error in the plot that you were sent. If kx is the frequency axis, i.e., values from (0,Nyquist), then kx(l,Nyquist) is plotted versus PSD(0,Nyquist). This error is corrected in the attached plots. The plot you have appears to be the PSD of the original data with no hanning applied. The removal of the quadratic term appear to have a negligible effect on the PSD. It changes only the first couple of terms (which lie outside of the data valid range). The removal of the center feature has a much stronger effect.

  6. A novel sliding window algorithm for 2D discrete Fourier transform

    NASA Astrophysics Data System (ADS)

    Dong, Zhifang; Wu, Jiasong; Gui, Jiyong

    2015-12-01

    Discrete Fourier transform (DFT) is one of the most wildly used tools for signal processing. In this paper, a novel sliding window algorithm is presented for fast computing 2D DFT when sliding window shifts more than one-point. The propose algorithm computing the DFT of the current window using that of the previous window. For fast computation, we take advantage of the recursive process of 2D SDFT and butterfly-based algorithm. So it can be directly applied to 2D signal processing. The theoretical analysis shows that the computational complexity is equal to 2D SDFT when one sample comes into current window. As well, the number of additions and multiplications of our proposed algorithm are less than those of 2D vector radix FFT when sliding window shifts mutiple-point.

  7. 2D Fourier series representation of gravitational functionals in spherical coordinates

    NASA Astrophysics Data System (ADS)

    Ghobadi-Far, Khosro; Sharifi, Mohammad Ali; Sneeuw, Nico

    2016-05-01

    2D Fourier series representation of a scalar field like gravitational potential is conventionally derived by making use of the Fourier series of the Legendre functions in the spherical harmonic representation. This representation has been employed so far only in the case of a scalar field or the functionals that are related to it through a radial derivative. This paper provides a unified scheme to represent any gravitational functional in terms of spherical coordinates using a 2D Fourier series representation. The 2D Fourier series representation for each individual point is derived by transforming the spherical harmonics from the geocentric Earth-fixed frame to a rotated frame so that its equator coincides with the local meridian plane of that point. In the obtained formulation, each functional is linked to the potential in the spectral domain using a spectral transfer. We provide the spectral transfers of the first-, second- and third-order gradients of the gravitational potential in the local north-oriented reference frame and also those of some functionals of frequent use in the physical geodesy. The obtained representation is verified numerically. Moreover, spherical harmonic analysis of anisotropic functionals and contribution analysis of the third-order gradient tensor are provided as two numerical examples to show the power of the formulation. In conclusion, the 2D Fourier series representation on the sphere is generalized to functionals of the potential. In addition, the set of the spectral transfers can be considered as a pocket guide that provides the spectral characteristics of the functionals. Therefore, it extends the so-called Meissl scheme.

  8. Building a symbolic computer algebra toolbox to compute 2D Fourier transforms in polar coordinates.

    PubMed

    Dovlo, Edem; Baddour, Natalie

    2015-01-01

    The development of a symbolic computer algebra toolbox for the computation of two dimensional (2D) Fourier transforms in polar coordinates is presented. Multidimensional Fourier transforms are widely used in image processing, tomographic reconstructions and in fact any application that requires a multidimensional convolution. By examining a function in the frequency domain, additional information and insights may be obtained. The advantages of our method include: •The implementation of the 2D Fourier transform in polar coordinates within the toolbox via the combination of two significantly simpler transforms.•The modular approach along with the idea of lookup tables implemented help avoid the issue of indeterminate results which may occur when attempting to directly evaluate the transform.•The concept also helps prevent unnecessary computation of already known transforms thereby saving memory and processing time. PMID:26150988

  9. Tensor representation of color images and fast 2D quaternion discrete Fourier transform

    NASA Astrophysics Data System (ADS)

    Grigoryan, Artyom M.; Agaian, Sos S.

    2015-03-01

    In this paper, a general, efficient, split algorithm to compute the two-dimensional quaternion discrete Fourier transform (2-D QDFT), by using the special partitioning in the frequency domain, is introduced. The partition determines an effective transformation, or color image representation in the form of 1-D quaternion signals which allow for splitting the N × M-point 2-D QDFT into a set of 1-D QDFTs. Comparative estimates revealing the efficiency of the proposed algorithms with respect to the known ones are given. In particular, a proposed method of calculating the 2r × 2r -point 2-D QDFT uses 18N2 less multiplications than the well-known column-row method and method of calculation based on the symplectic decomposition. The proposed algorithm is simple to apply and design, which makes it very practical in color image processing in the frequency domain.

  10. Fourier Analysis of Musical Intervals

    NASA Astrophysics Data System (ADS)

    LoPresto, Michael C.

    2008-11-01

    Use of a microphone attached to a computer to capture musical sounds and software to display their waveforms and harmonic spectra has become somewhat commonplace. A recent article in The Physics Teacher aptly demonstrated the use of MacScope2 in just such a manner as a way to teach Fourier analysis.3 A logical continuation of this project is to use MacScope not just to analyze the Fourier composition of musical tones but also musical intervals.

  11. Fourier based methodology for simulating 2D-random shapes in heterogeneous materials

    NASA Astrophysics Data System (ADS)

    Mattrand, C.; Béakou, A.; Charlet, K.

    2015-08-01

    Gaining insights into the effects of microstructural details on materials behavior may be achieved by incorporating their attributes into numerical modeling. This requires us to make considerable efforts to feature heterogeneity morphology distributions and their spatial arrangement. This paper focuses on modeling the scatter observed in materials heterogeneity geometry. The proposed strategy is based on the development of a 1D-shape signature function representing the 2D-section of a given shape, on Fourier basis functions. The Fourier coefficients are then considered as random variables. This methodology has been applied to flax fibers which are gradually introduced into composite materials as a potential alternative to synthetic reinforcements. In this contribution, the influence of some underlying assumptions regarding the choice of one 1D-shape signature function, its discretization scheme and truncation level, and the best way of modeling the associated random variables is also investigated. Some configurations coming from the combination of these tuning parameters are found to be sufficiently relevant to render efficiently the morphometric factors of the observed fibers statistically speaking.

  12. Fourier Analysis of Musical Intervals

    ERIC Educational Resources Information Center

    LoPresto, Michael C.

    2008-01-01

    Use of a microphone attached to a computer to capture musical sounds and software to display their waveforms and harmonic spectra has become somewhat commonplace. A recent article in "The Physics Teacher" aptly demonstrated the use of MacScope in just such a manner as a way to teach Fourier analysis. A logical continuation of this project is to…

  13. Fourier analysis of blazar variability

    SciTech Connect

    Finke, Justin D.; Becker, Peter A.

    2014-08-10

    Blazars display strong variability on multiple timescales and in multiple radiation bands. Their variability is often characterized by power spectral densities (PSDs) and time lags plotted as functions of the Fourier frequency. We develop a new theoretical model based on the analysis of the electron transport (continuity) equation, carried out in the Fourier domain. The continuity equation includes electron cooling and escape, and a derivation of the emission properties includes light travel time effects associated with a radiating blob in a relativistic jet. The model successfully reproduces the general shapes of the observed PSDs and predicts specific PSD and time lag behaviors associated with variability in the synchrotron, synchrotron self-Compton, and external Compton emission components, from submillimeter to γ-rays. We discuss applications to BL Lacertae objects and to flat-spectrum radio quasars (FSRQs), where there are hints that some of the predicted features have already been observed. We also find that FSRQs should have steeper γ-ray PSD power-law indices than BL Lac objects at Fourier frequencies ≲ 10{sup –4} Hz, in qualitative agreement with previously reported observations by the Fermi Large Area Telescope.

  14. Ultrasonic Transducers for Fourier Analysis.

    ERIC Educational Resources Information Center

    Greenslade, Thomas B., Jr.

    1995-01-01

    Describes an experiment that uses the ultrasonic transducer for demonstrating the Fourier components of waveshapes such as the square and triangular waves produced by laboratory function generators. (JRH)

  15. Parallel map analysis on 2-D grids

    SciTech Connect

    Berry, M.; Comiskey, J.; Minser, K.

    1993-12-31

    In landscape ecology, computer modeling is used to assess habitat fragmentation and its ecological iMPLications. Specifically, maps (2-D grids) of habitat clusters must be analyzed to determine number, sizes and geometry of clusters. Models prior to this study relied upon sequential Fortran-77 programs which limited the sizes of maps and densities of clusters which could be analyzed. In this paper, we present more efficient computer models which can exploit recursion or parallelism. Significant improvements over the original Fortran-77 programs have been achieved using both recursive and nonrecursive C implementations on a variety of workstations such as the Sun Sparc 2, IBM RS/6000-350, and HP 9000-750. Parallel implementations on a 4096-processor MasPar MP-1 and a 32-processor CM-5 are also studied. Preliminary experiments suggest that speed improvements for the parallel model on the MasPar MP-1 (written in MPL) and on the CM-5 (written in C using CMMD) can be as much as 39 and 34 times faster, respectively, than the most efficient sequential C program on a Sun Sparc 2 for a 512 map. An important goal in this research effort is to produce a scalable map analysis algorithm for the identification and characterization of clusters for relatively large maps on massively-parallel computers.

  16. Comparison of 2D and 3D Fourier modal methods for modeling subwavelength-structured silicon waveguides

    NASA Astrophysics Data System (ADS)

    Kwiecien, Pavel; Richter, Ivan; Čtyroký, Jiří

    2012-02-01

    Frequency-domain Fourier modal methods have recently evolved into efficient tools for rigorous numerical modeling of a wide class of photonic and plasmonic structures and devices. In this contribution we describe the application of our 2D and 3D in-house tools, namely aperiodic rigorous coupled wave analysis (aRCWA) and bi-directional mode expansion propagation method using harmonic expansion (BEXX), on a recently described novel type of subwavelength grating (SWG) waveguides. They are created by means of periodically interlacing silicon segments with a superstrate material with a lower refractive index. It has been shown recently, both theoretically and experimentally, that for a suitable choice of SWG parameters such as grating period and duty cycle, the structure can support low-loss guided (Bloch) mode. Its effective index, mode profile and dispersion characteristics can thus be tailored to specific needs without the necessity of changing material composition. In our methods, either complex coordinate transformation or uniaxial anisotropic perfectly matched layers have been applied as efficient absorption boundary conditions. In order to reduce the number of expansion terms needed to reach required accuracy, the adaptive spatial resolution technique has been implemented. Structural symmetries of the devices can be fully utilized to this aim, too. Propagation constants of Bloch modes are also compared with those obtained with a full-vector film mode matching (FiMM) mode solver using the very simple effective medium theory (EMT).

  17. Comparison of 2D and 3D Fourier modal methods for modeling subwavelength-structured silicon waveguides

    NASA Astrophysics Data System (ADS)

    Kwiecien, Pavel; Richter, Ivan; Čtyroký, Jiří

    2011-09-01

    Frequency-domain Fourier modal methods have recently evolved into efficient tools for rigorous numerical modeling of a wide class of photonic and plasmonic structures and devices. In this contribution we describe the application of our 2D and 3D in-house tools, namely aperiodic rigorous coupled wave analysis (aRCWA) and bi-directional mode expansion propagation method using harmonic expansion (BEXX), on a recently described novel type of subwavelength grating (SWG) waveguides. They are created by means of periodically interlacing silicon segments with a superstrate material with a lower refractive index. It has been shown recently, both theoretically and experimentally, that for a suitable choice of SWG parameters such as grating period and duty cycle, the structure can support low-loss guided (Bloch) mode. Its effective index, mode profile and dispersion characteristics can thus be tailored to specific needs without the necessity of changing material composition. In our methods, either complex coordinate transformation or uniaxial anisotropic perfectly matched layers have been applied as efficient absorption boundary conditions. In order to reduce the number of expansion terms needed to reach required accuracy, the adaptive spatial resolution technique has been implemented. Structural symmetries of the devices can be fully utilized to this aim, too. Propagation constants of Bloch modes are also compared with those obtained with a full-vector film mode matching (FiMM) mode solver using the very simple effective medium theory (EMT).

  18. Recognition of rotated images using the multi-valued neuron and rotation-invariant 2D Fourier descriptors

    NASA Astrophysics Data System (ADS)

    Aizenberg, Evgeni; Bigio, Irving J.; Rodriguez-Diaz, Eladio

    2012-03-01

    The Fourier descriptors paradigm is a well-established approach for affine-invariant characterization of shape contours. In the work presented here, we extend this method to images, and obtain a 2D Fourier representation that is invariant to image rotation. The proposed technique retains phase uniqueness, and therefore structural image information is not lost. Rotation-invariant phase coefficients were used to train a single multi-valued neuron (MVN) to recognize satellite and human face images rotated by a wide range of angles. Experiments yielded 100% and 96.43% classification rate for each data set, respectively. Recognition performance was additionally evaluated under effects of lossy JPEG compression and additive Gaussian noise. Preliminary results show that the derived rotation-invariant features combined with the MVN provide a promising scheme for efficient recognition of rotated images.

  19. Constraint directed CAD tool for automatic latency-optimal implementation of 1-D and 2-D Fourier transforms

    NASA Astrophysics Data System (ADS)

    Nash, J. Gregory

    2002-07-01

    A specialized CAD tool is described that will take a user's high level code description of a non-uniform affinely indexed algorithm and automatically generate abstract latency-optimal systolic arrays. Emphasis has been placed on ease of use and the ability to either force conformation to specific design criteria or perform unconstrained explorations. How such design goals are achieved is illustrated in the context of LU decomposition and the matrix Lyapunov equation. The tool is then used to generate new 1-D and 2-D hardware efficient systolic arrays for the discreet Fourier transform that take advantage of the use of the radix-4 matrix decomposition.

  20. Fourier analysis of finite element preconditioned collocation schemes

    NASA Technical Reports Server (NTRS)

    Deville, Michel O.; Mund, Ernest H.

    1990-01-01

    The spectrum of the iteration operator of some finite element preconditioned Fourier collocation schemes is investigated. The first part of the paper analyses one-dimensional elliptic and hyperbolic model problems and the advection-diffusion equation. Analytical expressions of the eigenvalues are obtained with use of symbolic computation. The second part of the paper considers the set of one-dimensional differential equations resulting from Fourier analysis (in the tranverse direction) of the 2-D Stokes problem. All results agree with previous conclusions on the numerical efficiency of finite element preconditioning schemes.

  1. Real-time 2D floating-point fast Fourier transforms for seeker simulation

    NASA Astrophysics Data System (ADS)

    Chamberlain, Richard; Lord, Eric; Shand, David J.

    2002-07-01

    The floating point Fast Fourier Transform (FFT) is one of the most useful basic functions available to the image and signal processing engineer allowing many complex and detailed special functions to be implemented more simply in the frequency domain. In the Hardware-in-the-Loop field an image transformed using FFT would allow the designer to think about accurate frequency based simulation of seeker lens effects, motion blur, detector transfer functions and much more. Unfortunately, the transform requires many hundreds of thousands or millions of floating point operations on a single modest sized image making it impractical for realtime Hardware-in-the-Loop systems. .until now. This paper outlines the development, by Nallatech, of an FPGA based IEEE floating point core. It traces the subsequent use of this core to develop a full 256 X 256 FFT and filter process implemented on COTS hardware at frame rates up to 150Hz. This transform can be demonstrated to model optical transfer functions at a far greater accuracy than the current spatial models. Other applications and extensions of this technique will be discussed such as filtering for image tracking algorithms and in the simulation of radar processing in the frequency domain.

  2. Bi-planar 2D-to-3D registration in Fourier domain for stereoscopic x-ray motion tracking

    NASA Astrophysics Data System (ADS)

    Zosso, Dominique; Le Callennec, Benoît; Bach Cuadra, Meritxell; Aminian, Kamiar; Jolles, Brigitte M.; Thiran, Jean-Philippe

    2008-03-01

    In this paper we present a new method to track bone movements in stereoscopic X-ray image series of the knee joint. The method is based on two different X-ray image sets: a rotational series of acquisitions of the still subject knee that allows the tomographic reconstruction of the three-dimensional volume (model), and a stereoscopic image series of orthogonal projections as the subject performs movements. Tracking the movements of bones throughout the stereoscopic image series means to determine, for each frame, the best pose of every moving element (bone) previously identified in the 3D reconstructed model. The quality of a pose is reflected in the similarity between its theoretical projections and the actual radiographs. We use direct Fourier reconstruction to approximate the three-dimensional volume of the knee joint. Then, to avoid the expensive computation of digitally rendered radiographs (DRR) for pose recovery, we develop a corollary to the 3-dimensional central-slice theorem and reformulate the tracking problem in the Fourier domain. Under the hypothesis of parallel X-ray beams, the heavy 2D-to-3D registration of projections in the signal domain is replaced by efficient slice-to-volume registration in the Fourier domain. Focusing on rotational movements, the translation-relevant phase information can be discarded and we only consider scalar Fourier amplitudes. The core of our motion tracking algorithm can be implemented as a classical frame-wise slice-to-volume registration task. Results on both synthetic and real images confirm the validity of our approach.

  3. 2D Wavefront Sensor Analysis and Control

    1996-02-19

    This software is designed for data acquisition and analysis of two dimensional wavefront sensors. The software includes data acquisition and control functions for an EPIX frame grabber to acquire data from a computer and all the appropriate analysis functions necessary to produce and display intensity and phase information. This software is written in Visual Basic for windows.

  4. Estimating 2-D vector velocities using multidimensional spectrum analysis.

    PubMed

    Oddershede, Niels; Løvstakken, Lasse; Torp, Hans; Jensen, Jørgen Arendt

    2008-08-01

    Wilson (1991) presented an ultrasonic wideband estimator for axial blood flow velocity estimation through the use of the 2-D Fourier transform. It was shown how a single velocity component was concentrated along a line in the 2-D Fourier space, where the slope was given by the axial velocity. Later, it was shown that this approach could also be used for finding the lateral velocity component by also including a lateral sampling. A single velocity component would then be concentrated along a plane in the 3-D Fourier space, tilted according to the 2 velocity components. This paper presents 2 new velocity estimators for finding both the axial and lateral velocity components. The estimators essentially search for the plane in the 3- D Fourier space, where the integrated power spectrum is largest. The first uses the 3-D Fourier transform to find the power spectrum, while the second uses a minimum variance approach. Based on this plane, the axial and lateral velocity components are estimated. Several phantom measurements, for flow-to-depth angles of 60, 75, and 90 degrees, were performed. Multiple parallel lines were beamformed simultaneously, and 2 different receive apodization schemes were tried. The 2 estimators were then applied to the data. The axial velocity component was estimated with an average standard deviation below 2.8% of the peak velocity, while the average standard deviation of the lateral velocity estimates was between 2.0% and 16.4%. The 2 estimators were also tested on in vivo data from a transverse scan of the common carotid artery, showing the potential of the vector velocity estimation method under in vivo conditions. PMID:18986918

  5. Fourier analysis and synthesis tomography.

    SciTech Connect

    Wagner, Kelvin H.; Sinclair, Michael B.; Feldkuhn, Daniel

    2010-05-01

    Most far-field optical imaging systems rely on a lens and spatially-resolved detection to probe distinct locations on the object. We describe and demonstrate a novel high-speed wide-field approach to imaging that instead measures the complex spatial Fourier transform of the object by detecting its spatially-integrated response to dynamic acousto-optically synthesized structured illumination. Tomographic filtered backprojection is applied to reconstruct the object in two or three dimensions. This technique decouples depth-of-field and working-distance from resolution, in contrast to conventional imaging, and can be used to image biological and synthetic structures in fluoresced or scattered light employing coherent or broadband illumination. We discuss the electronically programmable transfer function of the optical system and its implications for imaging dynamic processes. Finally, we present for the first time two-dimensional high-resolution image reconstructions demonstrating a three-orders-of-magnitude improvement in depth-of-field over conventional lens-based microscopy.

  6. Nonlinear Fourier analysis with cnoidal waves

    SciTech Connect

    Osborne, A.R.

    1996-12-31

    Fourier analysis is one of the most useful tools to the ocean engineer. The approach allows one to analyze wave data and thereby to describe a dynamical motion in terms of a linear superposition of ordinary sine waves. Furthermore, the Fourier technique allows one to compute the response function of a fixed or floating structure: each sine wave in the wave or force spectrum yields a sine wave in the response spectrum. The counting of fatigue cycles is another area where the predictable oscillations of sine waves yield procedures for the estimation of the fatigue life of structures. The ocean environment, however, is a source of a number of nonlinear effects which must also be included in structure design. Nonlinearities in ocean waves deform the sinusoidal shapes into other kinds of waves such as the Stokes wave, cnoidal wave or solitary wave. A key question is: Does there exist a generalization of linear Fourier analysis which uses nonlinear basis functions rather than the familiar sine waves? Herein addresses the dynamics of nonlinear wave motion in shallow water where the basis functions are cnoidal waves and discuss nonlinear Fourier analysis in terms of a linear superposition of cnoidal waves plus their mutual nonlinear interactions. He gives a number of simple examples of nonlinear Fourier wave motion and then analyzes an actual surface-wave time series obtained on an offshore platform in the Adriatic Sea. Finally, he briefly discusses application of the cnoidal wave spectral approach to the computation of the frequency response function of a floating vessel. The results given herein will prove useful in future engineering studies for the design of fixed, floating and complaint offshore structures.

  7. Noninvasive deep Raman detection with 2D correlation analysis

    NASA Astrophysics Data System (ADS)

    Kim, Hyung Min; Park, Hyo Sun; Cho, Youngho; Jin, Seung Min; Lee, Kang Taek; Jung, Young Mee; Suh, Yung Doug

    2014-07-01

    The detection of poisonous chemicals enclosed in daily necessaries is prerequisite essential for homeland security with the increasing threat of terrorism. For the detection of toxic chemicals, we combined a sensitive deep Raman spectroscopic method with 2D correlation analysis. We obtained the Raman spectra from concealed chemicals employing spatially offset Raman spectroscopy in which incident line-shaped light experiences multiple scatterings before being delivered to inner component and yielding deep Raman signal. Furthermore, we restored the pure Raman spectrum of each component using 2D correlation spectroscopic analysis with chemical inspection. Using this method, we could elucidate subsurface component under thick powder and packed contents in a bottle.

  8. Microscale 2D separation systems for proteomic analysis

    PubMed Central

    Xu, Xin; Liu, Ke; Fan, Z. Hugh

    2012-01-01

    Microscale 2D separation systems have been implemented in capillaries and microfabricated channels. They offer advantages of faster analysis, higher separation efficiency and less sample consumption than the conventional methods, such as liquid chromatography (LC) in a column and slab gel electrophoresis. In this article, we review their recent advancement, focusing on three types of platforms, including 2D capillary electrophoresis (CE), CE coupling with capillary LC, and microfluidic devices. A variety of CE and LC modes have been employed to construct 2D separation systems via sophistically designed interfaces. Coupling of different separation modes has also been realized in a number of microfluidic devices. These separation systems have been applied for the proteomic analysis of various biological samples, ranging from a single cell to tumor tissues. PMID:22462786

  9. Fourier analysis of the SOR iteration

    NASA Technical Reports Server (NTRS)

    Leveque, R. J.; Trefethen, L. N.

    1986-01-01

    The SOR iteration for solving linear systems of equations depends upon an overrelaxation factor omega. It is shown that for the standard model problem of Poisson's equation on a rectangle, the optimal omega and corresponding convergence rate can be rigorously obtained by Fourier analysis. The trick is to tilt the space-time grid so that the SOR stencil becomes symmetrical. The tilted grid also gives insight into the relation between convergence rates of several variants.

  10. Fourier analysis of quadratic phase interferograms

    NASA Astrophysics Data System (ADS)

    Muñoz-Maciel, Jesús; Mora-González, Miguel; Casillas-Rodríguez, Francisco J.; Peña-Lecona, Francisco G.

    2015-06-01

    A phase demodulation method from a single interferogram with a quadratic phase term is developed. The fringe pattern being analysed may contain circular, elliptic or astigmatic fringes. The Fourier transform of such interferograms is seen to be also a sine or a cosine of a second order polynomial in both the real and imaginary parts. In this work we take a discrete Fourier transform of the fringe patterns and then we take separate inverse discrete transforms of the real and imaginary parts of the frequency spectrum. This results in two new interferograms corresponding to the sine and cosine of the quadratic term of the phase modulated by the sine and cosine of the linear term. The linear term of these interferograms may be recovered with similar procedures of fringe analysis from open fringe interferograms. Once the linear term is retrieved the quadratic phase of the interferogram being analysed can also be calculated. The present approach is also being investigated for interferograms with nearly circularly symmetry given that the phase contains some tilt. The described procedure of Fourier analysis from quadratic phase interferograms of nearly symmetric interferograms could be used instead of complex and time consuming algorithms for phase recovery from fringe patterns with closed fringes. Finally, the method is tested in simulated and real data.

  11. Fourier analysis: from cloaking to imaging

    NASA Astrophysics Data System (ADS)

    Wu, Kedi; Cheng, Qiluan; Wang, Guo Ping

    2016-04-01

    Regarding invisibility cloaks as an optical imaging system, we present a Fourier approach to analytically unify both Pendry cloaks and complementary media-based invisibility cloaks into one kind of cloak. By synthesizing different transfer functions, we can construct different devices to realize a series of interesting functions such as hiding objects (events), creating illusions, and performing perfect imaging. In this article, we give a brief review on recent works of applying Fourier approach to analysis invisibility cloaks and optical imaging through scattering layers. We show that, to construct devices to conceal an object, no constructive materials with extreme properties are required, making most, if not all, of the above functions realizable by using naturally occurring materials. As instances, we experimentally verify a method of directionally hiding distant objects and create illusions by using all-dielectric materials, and further demonstrate a non-invasive method of imaging objects completely hidden by scattering layers.

  12. Region-based Statistical Analysis of 2D PAGE Images

    PubMed Central

    Li, Feng; Seillier-Moiseiwitsch, Françoise; Korostyshevskiy, Valeriy R.

    2011-01-01

    A new comprehensive procedure for statistical analysis of two-dimensional polyacrylamide gel electrophoresis (2D PAGE) images is proposed, including protein region quantification, normalization and statistical analysis. Protein regions are defined by the master watershed map that is obtained from the mean gel. By working with these protein regions, the approach bypasses the current bottleneck in the analysis of 2D PAGE images: it does not require spot matching. Background correction is implemented in each protein region by local segmentation. Two-dimensional locally weighted smoothing (LOESS) is proposed to remove any systematic bias after quantification of protein regions. Proteins are separated into mutually independent sets based on detected correlations, and a multivariate analysis is used on each set to detect the group effect. A strategy for multiple hypothesis testing based on this multivariate approach combined with the usual Benjamini-Hochberg FDR procedure is formulated and applied to the differential analysis of 2D PAGE images. Each step in the analytical protocol is shown by using an actual dataset. The effectiveness of the proposed methodology is shown using simulated gels in comparison with the commercial software packages PDQuest and Dymension. We also introduce a new procedure for simulating gel images. PMID:21850152

  13. Effects of data gaps on Fourier Analysis

    NASA Astrophysics Data System (ADS)

    Negrea, Catalin; Munteanu, Costel; Echim, Marius

    2014-05-01

    Fourier Analysis is a vital and widely used tool in all branches of science that require advanced data processing. The method is often used via the Fast Fourier Transform (FFT) implementation readily available in most programming languages. This is a valid approach for data sets with equally spaced data points and no gaps. Such conditions are not always met in real situations where corrections and adjustments to the method are needed. We investigate the intrinsic limitations of four such methods when data gaps are present: 1) linear interpolations and FFT, 2) a direct implementation of the Discrete Fourier Transform, 3) a Z-Transform and 4) the Lomb-Scargle algorithm. Theoretical analysis tools can provide an insight as to the likely problems of such methods and we discuss the likely modifications to the computed spectra. Also, a time series with no data gaps and a constant sampling frequency is altered by introducing several gap configurations and the resulting spectra with the four methods are compared to highlight changes with respect to the original spectrum. Effects on the amplitude and phase of the resulting power spectral densities are analyzed for non-uniformly sampled solar wind data provided by the Venus Express spacecraft. Phase effects are also studied in the context of a sliding window approach. Research supported by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement no 313038/STORM, and a grant of the Romanian Ministry of National Education, CNCS - UEFISCDI, project number PN-II-ID-PCE-2012-4-0418.

  14. Fourier analysis of biological signals with a programmable calculator.

    PubMed

    Avolio, A P

    1984-01-01

    A Fourier analysis program written for the Texas Instruments TI-59 programmable calculator is presented. The program determines the Fourier coefficients of any time varying periodic signal. PMID:6546911

  15. Finite Element Analysis of 2-D Elastic Contacts Involving FGMs

    NASA Astrophysics Data System (ADS)

    Abhilash, M. N.; Murthy, H.

    2014-05-01

    The response of elastic indenters in contact with Functionally Graded Material (FGM) coated homogeneous elastic half space has been presented in the current paper. Finite element analysis has been used due to its ability to handle complex geometry, material, and boundary conditions. Indenters of different typical surface profiles have been considered and the problem has been idealized as a two-dimensional (2D) plane strain problem considering only normal loads. Initially, indenters were considered to be rigid and the results were validated with the solutions presented in the literature. The analysis has then been extended to the case of elastic indenters on FGM-coated half spaces and the results are discussed.

  16. A novel improved method for analysis of 2D diffusion relaxation data—2D PARAFAC-Laplace decomposition

    NASA Astrophysics Data System (ADS)

    Tønning, Erik; Polders, Daniel; Callaghan, Paul T.; Engelsen, Søren B.

    2007-09-01

    This paper demonstrates how the multi-linear PARAFAC model can with advantage be used to decompose 2D diffusion-relaxation correlation NMR spectra prior to 2D-Laplace inversion to the T2- D domain. The decomposition is advantageous for better interpretation of the complex correlation maps as well as for the quantification of extracted T2- D components. To demonstrate the new method seventeen mixtures of wheat flour, starch, gluten, oil and water were prepared and measured with a 300 MHz nuclear magnetic resonance (NMR) spectrometer using a pulsed gradient stimulated echo (PGSTE) pulse sequence followed by a Carr-Purcell-Meiboom-Gill (CPMG) pulse echo train. By varying the gradient strength, 2D diffusion-relaxation data were recorded for each sample. From these double exponentially decaying relaxation data the PARAFAC algorithm extracted two unique diffusion-relaxation components, explaining 99.8% of the variation in the data set. These two components were subsequently transformed to the T2- D domain using 2D-inverse Laplace transformation and quantitatively assigned to the oil and water components of the samples. The oil component was one distinct distribution with peak intensity at D = 3 × 10 -12 m 2 s -1 and T2 = 180 ms. The water component consisted of two broad populations of water molecules with diffusion coefficients and relaxation times centered around correlation pairs: D = 10 -9 m 2 s -1, T2 = 10 ms and D = 3 × 10 -13 m 2 s -1, T2 = 13 ms. Small spurious peaks observed in the inverse Laplace transformation of original complex data were effectively filtered by the PARAFAC decomposition and thus considered artefacts from the complex Laplace transformation. The oil-to-water ratio determined by PARAFAC followed by 2D-Laplace inversion was perfectly correlated with known oil-to-water ratio of the samples. The new method of using PARAFAC prior to the 2D-Laplace inversion proved to have superior potential in analysis of diffusion-relaxation spectra, as it

  17. Fourier analysis of multitracer cosmological surveys

    NASA Astrophysics Data System (ADS)

    Abramo, L. Raul; Secco, Lucas F.; Loureiro, Arthur

    2016-02-01

    We present optimal quadratic estimators for the Fourier analysis of cosmological surveys that detect several different types of tracers of large-scale structure. Our estimators can be used to simultaneously fit the matter power spectrum and the biases of the tracers - as well as redshift-space distortions (RSDs), non-Gaussianities (NGs), or any other effects that are manifested through differences between the clusterings of distinct species of tracers. Our estimators reduce to the one by Feldman, Kaiser & Peacock (FKP) in the case of a survey consisting of a single species of tracer. We show that the multitracer estimators are unbiased, and that their covariance is given by the inverse of the multitracer Fisher matrix. When the biases, RSDs and NGs are fixed to their fiducial values, and one is only interested in measuring the underlying power spectrum, our estimators are projected into the estimator found by Percival, Verde & Peacock. We have tested our estimators on simple (lognormal) simulated galaxy maps, and we show that it performs as expected, being either equivalent or superior to the FKP method in all cases we analysed. Finally, we have shown how to extend the multitracer technique to include the one-halo term of the power spectrum.

  18. Fourier functional analysis for unsteady aerodynamic modeling

    NASA Technical Reports Server (NTRS)

    Lan, C. Edward; Chin, Suei

    1991-01-01

    A method based on Fourier analysis is developed to analyze the force and moment data obtained in large amplitude forced oscillation tests at high angles of attack. The aerodynamic models for normal force, lift, drag, and pitching moment coefficients are built up from a set of aerodynamic responses to harmonic motions at different frequencies. Based on the aerodynamic models of harmonic data, the indicial responses are formed. The final expressions for the models involve time integrals of the indicial type advocated by Tobak and Schiff. Results from linear two- and three-dimensional unsteady aerodynamic theories as well as test data for a 70-degree delta wing are used to verify the models. It is shown that the present modeling method is accurate in producing the aerodynamic responses to harmonic motions and the ramp type motions. The model also produces correct trend for a 70-degree delta wing in harmonic motion with different mean angles-of-attack. However, the current model cannot be used to extrapolate data to higher angles-of-attack than that of the harmonic motions which form the aerodynamic model. For linear ramp motions, a special method is used to calculate the corresponding frequency and phase angle at a given time. The calculated results from modeling show a higher lift peak for linear ramp motion than for harmonic ramp motion. The current model also shows reasonably good results for the lift responses at different angles of attack.

  19. Smooth 2-D ocean sound speed from Laplace and Laplace-Fourier domain inversion of seismic oceanography data

    NASA Astrophysics Data System (ADS)

    Blacic, Tanya M.; Jun, Hyunggu; Rosado, Hayley; Shin, Changsoo

    2016-02-01

    In seismic oceanography, processed images highlight small temperature changes, but inversion is needed to obtain absolute temperatures. Local search-based full waveform inversion has a lower computational cost than global search but requires accurate starting models. Unfortunately, most marine seismic data have little associated hydrographic data and the band-limited nature of seismic data makes extracting the long wavelength sound speed trend directly from seismic data inherently challenging. Laplace and Laplace-Fourier domain inversion (LDI) can use rudimentary starting models without prior information about the medium. Data are transformed to the Laplace domain, and a smooth sound speed model is extracted by examining the zero and low frequency components of the damped wavefield. We applied LDI to five synthetic data sets based on oceanographic features and recovered smoothed versions of our synthetic models, showing the viability of LDI for creating starting models suitable for more detailed inversions.

  20. Rovibrational constants of the ground state and v9 = 1 state of 13C2D4 by high-resolution Fourier transform infrared spectroscopy

    NASA Astrophysics Data System (ADS)

    Tan, T. L.; Gabona, M. G.; Woo, J. Q.; Ng, L. L.; Wong, Andy; McNaughton, Don

    2016-03-01

    The Fourier transform infrared (FTIR) rovibrational spectrum of the b-type ν9 band of 13C2D4 was recorded at a unapodized resolution of 0.0063 cm-1 in the 2230-2450 cm-1 region. By assigning and fitting a total of 1171 rotationally resolved infrared transitions of the ν9 band and using the Watson's A-reduced Hamiltonian in the Ir representation, rovibrational constants for the upper state (v9 = 1) up to five quartic centrifugal distortion terms were derived for the first time. The root-mean-square (rms) deviation of the infrared fit was 0.00043 cm-1. The ground state constants of 13C2D4 were determined with higher accuracy than previously by fitting 1485 ground state combination-differences (GSCDs) from the present and previous infrared measurements, with rms deviation of 0.00034 cm-1. The band center of ν9 band of 13C2D4 was determined to be at 2324.3593 cm-1. The equilibrium state rovibrational constants up to all 5 quartic terms were derived from theoretical harmonic calculations at three levels of theory: B3LYP/cc-pVTZ, MP2/cc-pVTZ, and CCSD/cc-pVTZ using the principal axis coordinate system. These constants agreed reasonably well with the ground state constants of 13C2D4 derived from the present experimental GSCD fit. Furthermore, all 3 rotational constants of the upper state (v9 = 1) and of the ground state of 13C2D4 were obtained from anharmonic calculations using B3LYP and MP2 levels with the cc-pVTZ basis set. The calculated rotational constants were found to agree with those derived experimentally within 0.40%.

  1. Analysis of eccentric photorefraction by Fourier optics

    NASA Astrophysics Data System (ADS)

    Liu, Yong; Chen, Jiabi

    2007-03-01

    Eccentric photorefraction usually is used as early eyesight diagnostic test of infants and small children. Unlike currently approved geometrical optical model of eccentric photorefractometer, the crescent formation and the light-intensity distribution in the pupil image of a myopic eye are analyzed by Fourier optics with the assumption of an isotropic scattering retina. In the case of little circular light source and rectangular slit, the simulation results of different myopic diopters are obtained by geometrical optical theory and Fourier optics respectively. It is found that the simulation results by Fourier optics are similar as those obtained by geometrical optics, and all simulations are almost corresponding to the experimental result. The result demonstrates that the new method presented here is feasible.

  2. Retrospective analysis of 2D patient-specific IMRT verifications

    SciTech Connect

    Childress, Nathan L.; White, R. Allen; Bloch, Charles; Salehpour, Mohammad; Dong, Lei; Rosen, Isaac I.

    2005-04-01

    We performed 858 two-dimensional (2D) patient-specific intensity modulated radiotherapy verifications over a period of 18 months. Multifield, composite treatment plans were measured in phantom using calibrated Kodak EDR2 film and compared with the calculated dose extracted from two treatment planning systems. This research summarizes our findings using the normalized agreement test (NAT) index and the percent of pixels failing the gamma index as metrics to represent the agreement between measured and computed dose distributions. An in-house dose comparison software package was used to register and compare all verifications. We found it was important to use an automatic positioning algorithm to achieve maximum registration accuracy, and that our automatic algorithm agreed well with anticipated results from known phantom geometries. We also measured absolute dose for each case using an ion chamber. Because the computed distributions agreed with ion chamber measurements better than the EDR2 film doses, we normalized EDR2 data to the computed distributions. The distributions of both the NAT indices and the percentage of pixels failing the gamma index were found to be exponential distributions. We continue to use both the NAT index and percent of pixels failing gamma with 5%/3 mm criteria to evaluate future verifications, as these two metrics were found to be complementary. Our data showed that using 2%/2 mm or 3%/3 mm criteria produces results similar to those using 5%/3 mm criteria. Normalized comparisons that have a NAT index greater than 45 and/or more than 20% of the pixels failing gamma for 5%/3 mm criteria represent outliers from our clinical data set and require further analysis. Because our QA verification results were exponentially distributed, rather than a tight grouping of similar results, we continue to perform patient-specific QA in order to identify and correct outliers in our verifications. The data from this work could be useful as a reference for

  3. Double Fourier analysis for Emotion Identification in Voiced Speech

    NASA Astrophysics Data System (ADS)

    Sierra-Sosa, D.; Bastidas, M.; Ortiz P., D.; Quintero, O. L.

    2016-04-01

    We propose a novel analysis alternative, based on two Fourier Transforms for emotion recognition from speech. Fourier analysis allows for display and synthesizes different signals, in terms of power spectral density distributions. A spectrogram of the voice signal is obtained performing a short time Fourier Transform with Gaussian windows, this spectrogram portraits frequency related features, such as vocal tract resonances and quasi-periodic excitations during voiced sounds. Emotions induce such characteristics in speech, which become apparent in spectrogram time-frequency distributions. Later, the signal time-frequency representation from spectrogram is considered an image, and processed through a 2-dimensional Fourier Transform in order to perform the spatial Fourier analysis from it. Finally features related with emotions in voiced speech are extracted and presented.

  4. Electrocardiogram analysis through time discrete Fourier transform

    NASA Astrophysics Data System (ADS)

    Lancaster, Cameron; Zhang, Guoping

    2011-03-01

    The motivation for this research is to find an alternative method to diagnose heart conditions. This can be accomplished by analyzing wave patterns in EKG data, and using the Fourier Transform to compare steady wave patterns against fibrillating wave patterns. The two main contributors are the following: heart electricity and Fourier Transform. Also, it is recognized that ion movement has potential to change the frequency in any heart beat signal. This effect is caused due to a strong electrostatic attraction that causes the membrane capacitance to build charge. For a single ion focus, the Nernst Potential influences the equilibrium potential for the membrane of an ion. If two or more ions are contributing to an electric field charge, the Goldman-Hodgkin-Katz will find the membrane equilibrium potential. If a membrane has an efflux, or influx, of ions, then it is possible to get the passive flow of the electric current to zero. In continued research, we will gain knowledge of solving equations; such as ionic flux, quantitative diffusion, electric current density, and more. The finishing portion of this research will be to compare the Fourier Transformed wave graphs to determine heart conditions. Supported by U.S. Department of Energy under Contract No. DE-FG02-06ER46304 and Indiana State University.

  5. Fourier mode analysis of source iteration in spatially periodic media

    SciTech Connect

    Zika, M.R.; Larsen, E.W.

    1998-12-31

    The standard Fourier mode analysis is an indispensable tool when designing acceleration techniques for transport iterations; however, it requires the assumption of a homogeneous infinite medium. For problems of practical interest, material heterogeneities may significantly impact iterative performance. Recent work has applied a Fourier analysis to the discretized two-dimensional transport operator with heterogeneous material properties. The results of these analyses may be difficult to interpret because the heterogeneity effects are inherently coupled to the discretization effects. Here, the authors describe a Fourier analysis of source iteration (SI) that allows the calculation of the eigenvalue spectrum for the one-dimensional continuous transport operator with spatially periodic heterogeneous media.

  6. The 2D large deformation analysis using Daubechies wavelet

    NASA Astrophysics Data System (ADS)

    Liu, Yanan; Qin, Fei; Liu, Yinghua; Cen, Zhangzhi

    2010-01-01

    In this paper, Daubechies (DB) wavelet is used for solution of 2D large deformation problems. Because the DB wavelet scaling functions are directly used as basis function, no meshes are needed in function approximation. Using the DB wavelet, the solution formulations based on total Lagrangian approach for two-dimensional large deformation problems are established. Due to the lack of Kroneker delta properties in wavelet scaling functions, Lagrange multipliers are used for imposition of boundary condition. Numerical examples of 2D large deformation problems illustrate that this method is effective and stable.

  7. Linked Gas Chromatography/Fourier Transform Infrared Spectrometry/Fourier Transform Mass Spectrometry For Mixture Analysis

    NASA Astrophysics Data System (ADS)

    Laude, David A., Jr.; Johlman, Carolyn; Wilkins, Charles L.

    1985-12-01

    During the past few years it has been demonstrated that linkage of multiple spectrometry systems with gas chromatography (GC) offers significant advantages for structural analysis of mixture components as they are sepa-rated. In the work to be described, a Fourier transform mass spectrometer (FTMS) has been linked in parallel with a Fourier transform infrared (FTIR) spectrometer for concurrent analysis of GC eluants from a fused silica capillary column. This system provides FTIR, electron impact, and chemical ionization mass spectral analysis of each mixture component as it emerges from the GC. Furthermore, mass measurement accuracy in the low ppm range in the absence of calibrant is made possible by the FTMS. Effective use of the com-plementary information obtained is shown to produce more reliable analytical performance than for any individual measurement.

  8. Statistical analysis of quiet stance sway in 2-D

    PubMed Central

    DiZio, Paul; Lackner, James R.

    2014-01-01

    Subjects exposed to a rotating environment that perturbs their postural sway show adaptive changes in their voluntary spatially directed postural motion to restore accurate movement paths but do not exhibit any obvious learning during passive stance. We have found, however, that a variable known to characterize the degree of stochasticity in quiet stance can also reveal subtle learning phenomena in passive stance. We extended Chow and Collins (Phys Rev E 52(1):909–912, 1995) one-dimensional pinned-polymer model (PPM) to two dimensions (2-D) and then evaluated the model’s ability to make analytical predictions for 2-D quiet stance. To test the model, we tracked center of mass and centers of foot pressures, and compared and contrasted stance sway for the anterior–posterior versus medio-lateral directions before, during, and after exposure to rotation at 10 rpm. Sway of the body during rotation generated Coriolis forces that acted perpendicular to the direction of sway. We found significant adaptive changes for three characteristic features of the mean square displacement (MSD) function: the exponent of the power law defined at short time scales, the proportionality constant of the power law, and the saturation plateau value defined at longer time scales. The exponent of the power law of MSD at a short time scale lies within the bounds predicted by the 2-D PPM. The change in MSD during exposure to rotation also had a power-law exponent in the range predicted by the theoretical model. We discuss the Coriolis force paradigm for studying postural and movement control and the applicability of the PPM model in 2-D for studying postural adaptation. PMID:24477760

  9. Statistical analysis of quiet stance sway in 2-D.

    PubMed

    Bakshi, Avijit; DiZio, Paul; Lackner, James R

    2014-04-01

    Subjects exposed to a rotating environment that perturbs their postural sway show adaptive changes in their voluntary spatially directed postural motion to restore accurate movement paths but do not exhibit any obvious learning during passive stance. We have found, however, that a variable known to characterize the degree of stochasticity in quiet stance can also reveal subtle learning phenomena in passive stance. We extended Chow and Collins (Phys Rev E 52(1):909-912, 1995) one-dimensional pinned-polymer model (PPM) to two dimensions (2-D) and then evaluated the model's ability to make analytical predictions for 2-D quiet stance. To test the model, we tracked center of mass and centers of foot pressures, and compared and contrasted stance sway for the anterior-posterior versus medio-lateral directions before, during, and after exposure to rotation at 10 rpm. Sway of the body during rotation generated Coriolis forces that acted perpendicular to the direction of sway. We found significant adaptive changes for three characteristic features of the mean square displacement (MSD) function: the exponent of the power law defined at short time scales, the proportionality constant of the power law, and the saturation plateau value defined at longer time scales. The exponent of the power law of MSD at a short time scale lies within the bounds predicted by the 2-D PPM. The change in MSD during exposure to rotation also had a power-law exponent in the range predicted by the theoretical model. We discuss the Coriolis force paradigm for studying postural and movement control and the applicability of the PPM model in 2-D for studying postural adaptation. PMID:24477760

  10. Xgremlin: Interferograms and spectra from Fourier transform spectrometers analysis

    NASA Astrophysics Data System (ADS)

    Nave, G.; Griesmann, U.; Brault, J. W.; Abrams, M. C.

    2015-11-01

    Xgremlin is a hardware and operating system independent version of the data analysis program Gremlin used for Fourier transform spectrometry. Xgremlin runs on PCs and workstations that use the X11 window system, including cygwin in Windows. It is used to Fourier transform interferograms, plot spectra, perform phase corrections, perform intensity and wavenumber calibration, and find and fit spectral lines. It can also be used to construct synthetic spectra, subtract continua, compare several different spectra, and eliminate ringing around lines.

  11. 2D axisymmetric analysis of SRM ignition transient

    NASA Astrophysics Data System (ADS)

    Bai, S. D.; Han, Samuel S.; Pardue, B. A.

    1993-06-01

    To analyze ignition transient of Space Shuttle solid rocket motor, a transient two-dimensional numerical model based on turbulent compressible Navier-Stokes equations in a generalized coordinate system was developed. One-dimensional numerical models (Peretz et al., 1973; Han, 1992; Pardue and Han, 1992) with empirical correlations data obtained from steady turbulent boundary layer flows agrees reasonably well with test rocket data by adjusting a few parameters. However, a 1D model can not provide a physical insight into the complex multidimensional thermal fields and flowfields in the chamber and the converging-diverging rocket nozzle. As an interim step, a 2D model was developed and compared with test data. A modified version of SIMPLE algorithm was used for the numerical model, and the standard k-epsilon model with a wall function was used for turbulence closure. Transient flowfields and thermal fields in the combustion chamber and the attached nozzle were obtained for a selected rocket geometry and propellant. Transient behaviors of the flow and thermal fields were analyzed, and were found to be in good agreement with physical expectations.

  12. VAM2D: Variably saturated analysis model in two dimensions

    SciTech Connect

    Huyakorn, P.S.; Kool, J.B.; Wu, Y.S. )

    1991-10-01

    This report documents a two-dimensional finite element model, VAM2D, developed to simulate water flow and solute transport in variably saturated porous media. Both flow and transport simulation can be handled concurrently or sequentially. The formulation of the governing equations and the numerical procedures used in the code are presented. The flow equation is approximated using the Galerkin finite element method. Nonlinear soil moisture characteristics and atmospheric boundary conditions (e.g., infiltration, evaporation and seepage face), are treated using Picard and Newton-Raphson iterations. Hysteresis effects and anisotropy in the unsaturated hydraulic conductivity can be taken into account if needed. The contaminant transport simulation can account for advection, hydrodynamic dispersion, linear equilibrium sorption, and first-order degradation. Transport of a single component or a multi-component decay chain can be handled. The transport equation is approximated using an upstream weighted residual method. Several test problems are presented to verify the code and demonstrate its utility. These problems range from simple one-dimensional to complex two-dimensional and axisymmetric problems. This document has been produced as a user's manual. It contains detailed information on the code structure along with instructions for input data preparation and sample input and printed output for selected test problems. Also included are instructions for job set up and restarting procedures. 44 refs., 54 figs., 24 tabs.

  13. Imaging Fourier transform spectrometer (IFTS): parametric sensitivity analysis

    NASA Astrophysics Data System (ADS)

    Keller, Robert A.; Lomheim, Terrence S.

    2005-06-01

    Imaging Fourier transform spectrometers (IFTS) allow for very high spectral resolution hyperspectral imaging while using moderate size 2D focal plane arrays in a staring mode. This is not the case for slit scanning dispersive imaging spectrometers where spectral sampling is related to the focal plane pixel count along the spectral dimension of the 2D focal plane used in such an instrument. This can become a major issue in the longwave infrared (LWIR) where the operability and yield of highly sensitivity arrays (i.e.HgCdTe) of large dimension are generally poor. However using an IFTS introduces its own unique set of issues and tradeoffs. In this paper we develop simplified equations for describing the sensitivity of an IFTS, including the effects of data windowing. These equations provide useful insights into the optical, focal plane and operational design trade space that must be considered when examining IFTS concepts aimed at a specific sensitivity and spectral resolution application. The approach is illustrated by computing the LWIR noise-equivalent spectral radiance (NESR) corresponding to the NASA Geosynchronous Imaging Fourier Transform Spectrometer (GIFTS) concept assuming a proven and reasonable noise-equivalent irradiance (NEI) capability for the focal plane.

  14. Comparative analysis of imaging configurations and objectives for Fourier microscopy.

    PubMed

    Kurvits, Jonathan A; Jiang, Mingming; Zia, Rashid

    2015-11-01

    Fourier microscopy is becoming an increasingly important tool for the analysis of optical nanostructures and quantum emitters. However, achieving quantitative Fourier space measurements requires a thorough understanding of the impact of aberrations introduced by optical microscopes that have been optimized for conventional real-space imaging. Here we present a detailed framework for analyzing the performance of microscope objectives for several common Fourier imaging configurations. To this end, we model objectives from Nikon, Olympus, and Zeiss using parameters that were inferred from patent literature and confirmed, where possible, by physical disassembly. We then examine the aberrations most relevant to Fourier microscopy, including the alignment tolerances of apodization factors for different objective classes, the effect of magnification on the modulation transfer function, and vignetting-induced reductions of the effective numerical aperture for wide-field measurements. Based on this analysis, we identify an optimal objective class and imaging configuration for Fourier microscopy. In addition, the Zemax files for the objectives and setups used in this analysis have been made publicly available as a resource for future studies. PMID:26560923

  15. Image inpainting on the basis of spectral structure from 2-D nonharmonic analysis.

    PubMed

    Hasegawa, Masaya; Kako, Takahiro; Hirobayashi, Shigeki; Misawa, Tadanobu; Yoshizawa, Toshio; Inazumi, Yasuhiro

    2013-08-01

    The restoration of images by digital inpainting is an active field of research and such algorithms are, in fact, now widely used. Conventional methods generally apply textures that are most similar to the areas around the missing region or use a large image database. However, this produces discontinuous textures and thus unsatisfactory results. Here, we propose a new technique to overcome this limitation by using signal prediction based on the nonharmonic analysis (NHA) technique proposed by the authors. NHA can be used to extract accurate spectra, irrespective of the window function, and its frequency resolution is less than that of the discrete Fourier transform. The proposed method sequentially generates new textures on the basis of the spectrum obtained by NHA. Missing regions from the spectrum are repaired using an improved cost function for 2D NHA. The proposed method is evaluated using the standard images Lena, Barbara, Airplane, Pepper, and Mandrill. The results show an improvement in MSE of about 10-20 compared with the examplar-based method and good subjective quality. PMID:23549889

  16. Fourier analysis of cell-wise Block-Jacobi splitting in two-dimensional geometry

    SciTech Connect

    Rosa, Massimiliano; Warsa, James S; Kelley, Timothy M

    2009-01-01

    A Fourier analysis is conducted in two-dimensional (2D) geometry for the discrete-ordinates (SN) approximation of the neutron transport problem solved with Richardson iteration (Source Iteration) using the cell-wise Block-Jacobi (B1) algorithm. The results of the Fourier analysis show that convergence of cell-wise BJ can degrade, leading to a spectral radius equal to 1, in problems containing optically thin cells. For problems containing cells that are optically thick, instead, the spectral radius tends to O. Hence, in the optically thick-cell regime, cell-wise BJ is rapidly convergent even for problems that are scattering dominated, with a scattering ratio c close to I.

  17. Fast Fourier transform analysis of rotor-bearing systems

    NASA Technical Reports Server (NTRS)

    Choy, K. C.; Gunter, E. J.; Allaire, P. E.

    1978-01-01

    Nonlinear transient analysis of rotor-bearing systems is becoming increasingly important in the analysis of modern-day rotating machinery to model such phenomena as oil film whirl. This paper develops an analysis technique incorporating modal analysis and fast Fourier transform techniques to analyze rotors with residual shaft bow and realistic nonlinear bearings. The technique is demonstrated on single-mass and three-mass rotor examples. Comparisons of the theoretical results with experimental data give excellent agreement.

  18. Multifractal analysis of 2D gray soil images

    NASA Astrophysics Data System (ADS)

    González-Torres, Ivan; Losada, Juan Carlos; Heck, Richard; Tarquis, Ana M.

    2015-04-01

    Soil structure, understood as the spatial arrangement of soil pores, is one of the key factors in soil modelling processes. Geometric properties of individual and interpretation of the morphological parameters of pores can be estimated from thin sections or 3D Computed Tomography images (Tarquis et al., 2003), but there is no satisfactory method to binarized these images and quantify the complexity of their spatial arrangement (Tarquis et al., 2008, Tarquis et al., 2009; Baveye et al., 2010). The objective of this work was to apply a multifractal technique, their singularities (α) and f(α) spectra, to quantify it without applying any threshold (Gónzalez-Torres, 2014). Intact soil samples were collected from four horizons of an Argisol, formed on the Tertiary Barreiras group of formations in Pernambuco state, Brazil (Itapirema Experimental Station). The natural vegetation of the region is tropical, coastal rainforest. From each horizon, showing different porosities and spatial arrangements, three adjacent samples were taken having a set of twelve samples. The intact soil samples were imaged using an EVS (now GE Medical. London, Canada) MS-8 MicroCT scanner with 45 μm pixel-1 resolution (256x256 pixels). Though some samples required paring to fit the 64 mm diameter imaging tubes, field orientation was maintained. References Baveye, P.C., M. Laba, W. Otten, L. Bouckaert, P. Dello, R.R. Goswami, D. Grinev, A. Houston, Yaoping Hu, Jianli Liu, S. Mooney, R. Pajor, S. Sleutel, A. Tarquis, Wei Wang, Qiao Wei, Mehmet Sezgin. Observer-dependent variability of the thresholding step in the quantitative analysis of soil images and X-ray microtomography data. Geoderma, 157, 51-63, 2010. González-Torres, Iván. Theory and application of multifractal analysis methods in images for the study of soil structure. Master thesis, UPM, 2014. Tarquis, A.M., R.J. Heck, J.B. Grau; J. Fabregat, M.E. Sanchez and J.M. Antón. Influence of Thresholding in Mass and Entropy Dimension of 3-D

  19. Lagrangian analysis of vortex shedding behind a 2D airfoil

    NASA Astrophysics Data System (ADS)

    Cardwell, Blake; Mohseni, Kamran

    2007-11-01

    Identifying the coherent structures and their interactions in the mixing zone is a useful means in designing future flow control strategies. To this end, a Lagrangian analysis of two-dimensional vortex shedding over an Eppler 387 airfoil is presented. Stable and unstable material manifolds in the flow are identified. Unstable manifolds such a the shear layer characterize a barrier to fluid mixing and are easily visualized using dye injection in an experiment. On the other hand, stable manifolds are more difficult to visualize in an experiment. Reattachment lines are examples of such manifolds. As such the existence of these structures in the flow, is presented and how these structures are useful in understanding vortex shedding is explored. The manifold structure is also presented in a time averaged view, allowing a comparison with the traditional separation bubble. Furthermore, lobe dynamic calculation are performed and the fluid entrainment into shedded vortices are investigated. Finally, investigation of correlation between the behavior of the material manifolds and more traditional quantities such as skin friction, flow phase portrait, and pressure is presented.

  20. Discrete Fourier Transform Analysis in a Complex Vector Space

    NASA Technical Reports Server (NTRS)

    Dean, Bruce H.

    2009-01-01

    Alternative computational strategies for the Discrete Fourier Transform (DFT) have been developed using analysis of geometric manifolds. This approach provides a general framework for performing DFT calculations, and suggests a more efficient implementation of the DFT for applications using iterative transform methods, particularly phase retrieval. The DFT can thus be implemented using fewer operations when compared to the usual DFT counterpart. The software decreases the run time of the DFT in certain applications such as phase retrieval that iteratively call the DFT function. The algorithm exploits a special computational approach based on analysis of the DFT as a transformation in a complex vector space. As such, this approach has the potential to realize a DFT computation that approaches N operations versus Nlog(N) operations for the equivalent Fast Fourier Transform (FFT) calculation.

  1. On One Application of Fourier Analysis in Plastic Surgery

    NASA Astrophysics Data System (ADS)

    Rakhimov, Abdumalik; Zainuddin, Hishamuddin

    In present paper, we discuss the spectral methods of measurement of the degree of speech and/or quality of sound by comparing the coefficient of performance indicators depending on energy distributions, ratio of energy of the fundamental tone and energy of overtones. Such a method is very efficient for string oscillation with different initial conditions and it is useful for justification of applications of Fourier analysis in plastic surgery in treatment of some medical diseases.

  2. Two-Dimensional Fourier Transform Analysis of Helicopter Flyover Noise

    NASA Technical Reports Server (NTRS)

    SantaMaria, Odilyn L.; Farassat, F.; Morris, Philip J.

    1999-01-01

    A method to separate main rotor and tail rotor noise from a helicopter in flight is explored. Being the sum of two periodic signals of disproportionate, or incommensurate frequencies, helicopter noise is neither periodic nor stationary. The single Fourier transform divides signal energy into frequency bins of equal size. Incommensurate frequencies are therefore not adequately represented by any one chosen data block size. A two-dimensional Fourier analysis method is used to separate main rotor and tail rotor noise. The two-dimensional spectral analysis method is first applied to simulated signals. This initial analysis gives an idea of the characteristics of the two-dimensional autocorrelations and spectra. Data from a helicopter flight test is analyzed in two dimensions. The test aircraft are a Boeing MD902 Explorer (no tail rotor) and a Sikorsky S-76 (4-bladed tail rotor). The results show that the main rotor and tail rotor signals can indeed be separated in the two-dimensional Fourier transform spectrum. The separation occurs along the diagonals associated with the frequencies of interest. These diagonals are individual spectra containing only information related to one particular frequency.

  3. Vortex metrology using Fourier analysis techniques: vortex networks correlation fringes.

    PubMed

    Angel-Toro, Luciano; Sierra-Sosa, Daniel; Tebaldi, Myrian; Bolognini, Néstor

    2012-10-20

    In this work, we introduce an alternative method of analysis in vortex metrology based on the application of the Fourier optics techniques. The first part of the procedure is conducted as is usual in vortex metrology for uniform in-plane displacement determination. On the basis of two recorded intensity speckled distributions, corresponding to two states of a diffuser coherently illuminated, we numerically generate an analytical signal from each recorded intensity pattern by using a version of the Riesz integral transform. Then, from each analytical signal, a two-dimensional pseudophase map is generated in which the vortices are located and characterized in terms of their topological charges and their core's structural properties. The second part of the procedure allows obtaining Young's interference fringes when Fourier transforming the light passing through a diffracting mask with multiple apertures at the locations of the homologous vortices. In fact, we use the Fourier transform as a mathematical operation to compute the far-field diffraction intensity pattern corresponding to the multiaperture set. Each aperture from the set is associated with a rectangular hole that coincides both in shape and size with a pixel from recorded images. We show that the fringe analysis can be conducted as in speckle photography in an extended range of displacement measurements. Effects related with speckled decorrelation are also considered. Our experimental results agree with those of speckle photography in the range in which both techniques are applicable. PMID:23089799

  4. Fourier analysis of conductive heat transfer for glazed roofing materials

    SciTech Connect

    Roslan, Nurhana Lyana; Bahaman, Nurfaradila; Almanan, Raja Noorliyana Raja; Ismail, Razidah; Zakaria, Nor Zaini

    2014-07-10

    For low-rise buildings, roof is the most exposed surface to solar radiation. The main mode of heat transfer from outdoor via the roof is conduction. The rate of heat transfer and the thermal impact is dependent on the thermophysical properties of roofing materials. Thus, it is important to analyze the heat distribution for the various types of roofing materials. The objectives of this paper are to obtain the Fourier series for the conductive heat transfer for two types of glazed roofing materials, namely polycarbonate and polyfilled, and also to determine the relationship between the ambient temperature and the conductive heat transfer for these materials. Ambient and surface temperature data were collected from an empirical field investigation in the campus of Universiti Teknologi MARA Shah Alam. The roofing materials were installed on free-standing structures in natural ventilation. Since the temperature data are generally periodic, Fourier series and numerical harmonic analysis are applied. Based on the 24-point harmonic analysis, the eleventh order harmonics is found to generate an adequate Fourier series expansion for both glazed roofing materials. In addition, there exists a linear relationship between the ambient temperature and the conductive heat transfer for both glazed roofing materials. Based on the gradient of the graphs, lower heat transfer is indicated through polyfilled. Thus polyfilled would have a lower thermal impact compared to polycarbonate.

  5. Fourier analysis of conductive heat transfer for glazed roofing materials

    NASA Astrophysics Data System (ADS)

    Roslan, Nurhana Lyana; Bahaman, Nurfaradila; Almanan, Raja Noorliyana Raja; Ismail, Razidah; Zakaria, Nor Zaini

    2014-07-01

    For low-rise buildings, roof is the most exposed surface to solar radiation. The main mode of heat transfer from outdoor via the roof is conduction. The rate of heat transfer and the thermal impact is dependent on the thermophysical properties of roofing materials. Thus, it is important to analyze the heat distribution for the various types of roofing materials. The objectives of this paper are to obtain the Fourier series for the conductive heat transfer for two types of glazed roofing materials, namely polycarbonate and polyfilled, and also to determine the relationship between the ambient temperature and the conductive heat transfer for these materials. Ambient and surface temperature data were collected from an empirical field investigation in the campus of Universiti Teknologi MARA Shah Alam. The roofing materials were installed on free-standing structures in natural ventilation. Since the temperature data are generally periodic, Fourier series and numerical harmonic analysis are applied. Based on the 24-point harmonic analysis, the eleventh order harmonics is found to generate an adequate Fourier series expansion for both glazed roofing materials. In addition, there exists a linear relationship between the ambient temperature and the conductive heat transfer for both glazed roofing materials. Based on the gradient of the graphs, lower heat transfer is indicated through polyfilled. Thus polyfilled would have a lower thermal impact compared to polycarbonate.

  6. Speech processing based on short-time Fourier analysis

    SciTech Connect

    Portnoff, M.R.

    1981-06-02

    Short-time Fourier analysis (STFA) is a mathematical technique that represents nonstationary signals, such as speech, music, and seismic signals in terms of time-varying spectra. This representation provides a formalism for such intuitive notions as time-varying frequency components and pitch contours. Consequently, STFA is useful for speech analysis and speech processing. This paper shows that STFA provides a convenient technique for estimating and modifying certain perceptual parameters of speech. As an example of an application of STFA of speech, the problem of time-compression or expansion of speech, while preserving pitch and time-varying frequency content is presented.

  7. Analysis of activity space by fragment fingerprints, 2D descriptors, and multitarget dependent transformation of 2D descriptors.

    PubMed

    Givehchi, Alireza; Bender, Andreas; Glen, Robert C

    2006-01-01

    The effect of multitarget dependent descriptor transformation on classification performance is explored in this work. To this end decision trees as well as neural net QSAR in combination with PLS were applied to predict the activity class of 5HT3 ligands, angiotensin converting enzyme inhibitors, 3-hydroxyl-3-methyl glutaryl coenzyme A reductase inhibitors, platelet activating factor antagonists, and thromboxane A2 antagonists. Physicochemical descriptors calculated by MOE and fragment-based descriptors (MOLPRINT 2D) were employed to generate descriptor vectors. In a subsequent step the physicochemical descriptor vectors were transformed to a lower dimensional space using multitarget dependent descriptor transformation. Cross-validation of the original physicochemical descriptors in combination with decision trees and neural net QSAR as well as cross-validation of PLS multitarget transformed descriptors with neural net QSAR were performed. For comparison this was repeated using fragment-based descriptors in combination with decision trees. PMID:16711727

  8. Fourier analysis and signal processing by use of the Moebius inversion formula

    NASA Technical Reports Server (NTRS)

    Reed, Irving S.; Yu, Xiaoli; Shih, Ming-Tang; Tufts, Donald W.; Truong, T. K.

    1990-01-01

    A novel Fourier technique for digital signal processing is developed. This approach to Fourier analysis is based on the number-theoretic method of the Moebius inversion of series. The Fourier transform method developed is shown also to yield the convolution of two signals. A computer simulation shows that this method for finding Fourier coefficients is quite suitable for digital signal processing. It competes with the classical FFT (fast Fourier transform) approach in terms of accuracy, complexity, and speed.

  9. Spatial Fourier analysis of video photobleaching measurements. Principles and optimization.

    PubMed

    Tsay, T T; Jacobson, K A

    1991-08-01

    The major use of the fluorescence recovery after photobleaching (FRAP) technique is to measure the translational motion of the molecular components in various condensed media. In a conventional laser spot photobleaching experiment, a photomultiplier is used to measure the total brightness levels of the bleached region in the sample, so no spatial information can be directly obtained. In video-FRAP, a series of images after photobleaching is acquired, allowing the spatial character of the recovery to be determined; this permits direct detection of both anisotropic diffusion and flow. To utilize all of the available image data to determine the transport coefficients, a two-dimensional spatial Fourier transform analysis of the images after photobleaching was employed. The change in the transform between two time points reflects the action of diffusion during the interim. An important advantage of this method, which involves taking the ratio of image transforms at different time points, is that it does not require a specific initial condition to be created by laser photobleaching. The ability of the analysis to extract transport coefficients from computer-simulated diffusional recovery is assessed in the presence of increasing amounts of noise. Experimental data analysis from the diffusion of proteins in viscous solutions and from the diffusion of protein receptors on cell surfaces demonstrate the feasibility of the Fourier analysis to obtain transport coefficients from the video FRAP measurement. PMID:1912279

  10. CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations.

    PubMed

    Province, M A; Goetz, M P; Brauch, H; Flockhart, D A; Hebert, J M; Whaley, R; Suman, V J; Schroth, W; Winter, S; Zembutsu, H; Mushiroda, T; Newman, W G; Lee, M-T M; Ambrosone, C B; Beckmann, M W; Choi, J-Y; Dieudonné, A-S; Fasching, P A; Ferraldeschi, R; Gong, L; Haschke-Becher, E; Howell, A; Jordan, L B; Hamann, U; Kiyotani, K; Krippl, P; Lambrechts, D; Latif, A; Langsenlehner, U; Lorizio, W; Neven, P; Nguyen, A T; Park, B-W; Purdie, C A; Quinlan, P; Renner, W; Schmidt, M; Schwab, M; Shin, J-G; Stingl, J C; Wegman, P; Wingren, S; Wu, A H B; Ziv, E; Zirpoli, G; Thompson, A M; Jordan, V C; Nakamura, Y; Altman, R B; Ames, M M; Weinshilboum, R M; Eichelbaum, M; Ingle, J N; Klein, T E

    2014-02-01

    The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (CYP2D6) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated patients (12 globally distributed sites). Using strict eligibility requirements (postmenopausal women with estrogen receptor-positive breast cancer, receiving 20 mg/day tamoxifen for 5 years, criterion 1); CYP2D6 poor metabolizer status was associated with poorer invasive disease-free survival (IDFS: hazard ratio = 1.25; 95% confidence interval = 1.06, 1.47; P = 0.009). However, CYP2D6 status was not statistically significant when tamoxifen duration, menopausal status, and annual follow-up were not specified (criterion 2, n = 2,443; P = 0.25) or when no exclusions were applied (criterion 3, n = 4,935; P = 0.38). Although CYP2D6 is a strong predictor of IDFS using strict inclusion criteria, because the results are not robust to inclusion criteria (these were not defined a priori), prospective studies are necessary to fully establish the value of CYP2D6 genotyping in tamoxifen therapy. PMID:24060820

  11. PLAN2D - A PROGRAM FOR ELASTO-PLASTIC ANALYSIS OF PLANAR FRAMES

    NASA Technical Reports Server (NTRS)

    Lawrence, C.

    1994-01-01

    PLAN2D is a FORTRAN computer program for the plastic analysis of planar rigid frame structures. Given a structure and loading pattern as input, PLAN2D calculates the ultimate load that the structure can sustain before collapse. Element moments and plastic hinge rotations are calculated for the ultimate load. The location of hinges required for a collapse mechanism to form are also determined. The program proceeds in an iterative series of linear elastic analyses. After each iteration the resulting elastic moments in each member are compared to the reserve plastic moment capacity of that member. The member or members that have moments closest to their reserve capacity will determine the minimum load factor and the site where the next hinge is to be inserted. Next, hinges are inserted and the structural stiffness matrix is reformulated. This cycle is repeated until the structure becomes unstable. At this point the ultimate collapse load is calculated by accumulating the minimum load factor from each previous iteration and multiplying them by the original input loads. PLAN2D is based on the program STAN, originally written by Dr. E.L. Wilson at U.C. Berkeley. PLAN2D has several limitations: 1) Although PLAN2D will detect unloading of hinges it does not contain the capability to remove hinges; 2) PLAN2D does not allow the user to input different positive and negative moment capacities and 3) PLAN2D does not consider the interaction between axial and plastic moment capacity. Axial yielding and buckling is ignored as is the reduction in moment capacity due to axial load. PLAN2D is written in FORTRAN and is machine independent. It has been tested on an IBM PC and a DEC MicroVAX. The program was developed in 1988.

  12. Particle field holography data reduction by Fourier transform analysis

    NASA Technical Reports Server (NTRS)

    Hess, Cecil F.; Trolinger, James D.

    1987-01-01

    The size distribution of a particle field hologram is obtained with a Fourier transformation of the Fraunhofer diffraction pattern of the reconstructed hologram. Off-axis absorption holograms of particle fields with known characteristics were obtained and analyzed with a commercially available instrument. The mean particle size of the reconstructed hologram was measured with an error of + or - 5 percent, while the distribution broadening was estimated within + or - 15 percent. Small sections of a pulsed laser hologram of a synthetic fuel spray were analyzed with this method thus yielding a spatially resolved size distribution. The method yields fast and accurate automated analysis of particle field holograms.

  13. Application of quantitative artificial neural network analysis to 2D NMR spectra of hydrocarbon mixtures.

    PubMed

    Väänänen, Taito; Koskela, Harri; Hiltunen, Yrjö; Ala-Korpela, Mika

    2002-01-01

    Understanding relationships between the structure and composition of molecular mixtures and their chemical properties is a main industrial aim. One central field of research is oil chemistry where the key question is how the molecular characteristics of composite hydrocarbon mixtures can be associated with the macroscopic properties of the oil products. Apparently these relationships are complex and often nonlinear and therefore call for advanced spectroscopic techniques. An informative and an increasingly used approach is two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy. In the case of composite hydrocarbons the application of 2D NMR methodologies in a quantitative manner pose many technical difficulties, and, in any case, the resulting spectra contain many overlapping resonances that challenge the analytical work. Here, we present a general methodology, based on quantitative artificial neural network (ANN) analysis, to resolve overlapping information in 2D NMR spectra and to simultaneously assess the relative importance of multiple spectral variables on the sample properties. The results in a set of 2D NMR spectra of oil samples illustrate, first, that use of ANN analysis for quantitative purposes is feasible also in 2D and, second, that this methodology offers an intrinsic opportunity to assess the complex and nonlinear relationships between the molecular composition and sample properties. The presented ANN methodology is not limited to the analysis of NMR spectra but can also be applied in a manner similar to other (multidimensional) spectroscopic data. PMID:12444730

  14. Dynamic Analysis of 2D Electromagnetic Resonant Optical Scanner Using 3D Finite Element Method

    NASA Astrophysics Data System (ADS)

    Hirata, Katsuhiro; Hong, Sara; Maeda, Kengo

    The optical scanner is a scanning device in which a laser beam is reflected by a mirror that can be rotated or oscillated. In this paper, we propose a new 2D electromagnetic resonant optical scanner that employs electromagnets and leaf springs. Torque characteristics and resonance characteristics of the scanner are analyzed using the 3D finite element method. The validity of the analysis is shown by comparing the characteristics inferred from the analysis with the characteristics of the prototype. Further, 2D resonance is investigated by introducing a superimposed-frequency current in a single coil.

  15. An F2D analysis of the Flow Instability Test (FIT) experiment

    SciTech Connect

    Suo-Anttila, A.

    1993-10-01

    The F2D code was used to analyze the Flow-Instability-Test (FIT) experiments at Brookhaven National Laboratories. A one-dimensional analysis of the experiment indicated that at the higher temperature levels the element should be unstable. The experimental data corroborated this theory. The two-dimensional simulation behaved in a manner that was very similar to the experimentally measured behavior. In conclusion, the FIT experimental analysis yields partial code validation of F2D, and it also validates the methodology that is used in analyzing thermal flow stability.

  16. Ultrasonic tissue characterization via 2-D spectrum analysis: theory and in vitro measurements

    PubMed Central

    Liu, Tian; Lizzi, Frederic L.; Ketterling, Jeffrey A.; Silverman, Ronald H.; Kutcher, Gerald J.

    2010-01-01

    A theoretical model is described for application in ultrasonic tissue characterization using a calibrated 2-D spectrum analysis method. This model relates 2-D spectra computed from ultrasonic backscatter signals to intrinsic physical properties of tissue microstructures, e.g., size, shape, and acoustic impedance. The model is applicable to most clinical diagnostic ultrasound systems. Two experiments employing two types of tissue architectures, spherical and cylindrical scatterers, are conducted using ultrasound with center frequencies of 10 and 40 MHz, respectively. Measurements of a tissue-mimicking phantom with an internal suspension of microscopic glass beads are used to validate the theoretical model. Results from in vitro muscle fibers are presented to further elucidate the utility of 2-D spectrum analysis in ultrasonic tissue characterization. PMID:17441250

  17. The Fourier analysis technique and epsilon-pseudo-eigenvalues

    SciTech Connect

    Donato, J.M.

    1993-07-01

    The spectral radii of iteration matrices and the spectra and condition numbers of preconditioned systems are important in forecasting the convergence rates for iterative methods. Unfortunately, the spectra of iteration matrices or preconditioned systems is rarely easily available. The Fourier analysis technique has been shown to be a useful tool in studying the effectiveness of iterative methods by determining approximate expressions for the eigenvalues or condition numbers of matrix systems. For non-symmetric matrices the eigenvalues may be highly sensitive to perturbations. The spectral radii of nonsymmetric iteration matrices may not give a numerically realistic indication of the convergence of the iterative method. Trefethen and others have presented a theory on the use of {epsilon}-pseudo-eigenvalues in the study of matrix equations. For Toeplitz matrices, we show that the theory of c-pseudo-eigenvalues includes the Fourier analysis technique as a limiting case. For non-Toeplitz matrices, the relationship is not clear. We shall examine this relationship for non-Toeplitz matrices that arise when studying preconditioned systems for methods applied to a two-dimensional discretized elliptic differential equation.

  18. Quantitative assessment of human body shape using Fourier analysis

    NASA Astrophysics Data System (ADS)

    Friess, Martin; Rohlf, F. J.; Hsiao, Hongwei

    2004-04-01

    Fall protection harnesses are commonly used to reduce the number and severity of injuries. Increasing the efficiency of harness design requires the size and shape variation of the user population to be assessed as detailed and as accurately as possible. In light of the unsatisfactory performance of traditional anthropometry with respect to such assessments, we propose the use of 3D laser surface scans of whole bodies and the statistical analysis of elliptic Fourier coefficients. Ninety-eight male and female adults were scanned. Key features of each torso were extracted as a 3D curve along front, back and the thighs. A 3D extension of Elliptic Fourier analysis4 was used to quantify their shape through multivariate statistics. Shape change as a function of size (allometry) was predicted by regressing the coefficients onto stature, weight and hip circumference. Upper and lower limits of torso shape variation were determined and can be used to redefine the design of the harness that will fit most individual body shapes. Observed allometric changes are used for adjustments to the harness shape in each size. Finally, the estimated outline data were used as templates for a free-form deformation of the complete torso surface using NURBS models (non-uniform rational B-splines).

  19. Non-Harmonic Fourier Analysis for bladed wheels damage detection

    NASA Astrophysics Data System (ADS)

    Neri, P.; Peeters, B.

    2015-11-01

    The interaction between bladed wheels and the fluid distributed by the stator vanes results in cyclic loading of the rotating components. Compressors and turbines wheels are subject to vibration and fatigue issues, especially when resonance conditions are excited. Even if resonance conditions can be often predicted and avoided, high cycle fatigue failures can occur, causing safety issues and economic loss. Rigorous maintenance programs are then needed, forcing the system to expensive shut-down. Blade crack detection methods are beneficial for condition-based maintenance. While contact measurement systems are not always usable in exercise conditions (e.g. high temperature), non-contact methods can be more suitable. One (or more) stator-fixed sensor can measure all the blades as they pass by, in order to detect the damaged ones. The main drawback in this situation is the short acquisition time available for each blade, which is shortened by the high rotational speed of the components. A traditional Discrete Fourier Transform (DFT) analysis would result in a poor frequency resolution. A Non-Harmonic Fourier Analysis (NHFA) can be executed with an arbitrary frequency resolution instead, allowing to obtain frequency information even with short-time data samples. This paper shows an analytical investigation of the NHFA method. A data processing algorithm is then proposed to obtain frequency shift information from short time samples. The performances of this algorithm are then studied by experimental and numerical tests.

  20. A Fourier analysis of symmetry in protein structure.

    PubMed

    Taylor, William R; Heringa, Jaap; Baud, Franck; Flores, Tomas P

    2002-02-01

    The score matrix from a structure comparison program (SAP) was used to search for repeated structures using a Fourier analysis. When tested with artificial data, a simple Fourier transform of the smoothed matrix provided a clear signal of the repeat periodicity that could be used to extract the repeating units with the SAP program. The strength of the Fourier signal was calibrated against the signal from model proteins. The most useful of these was the novel random-walk approach employed to generate realistic 'fake' structures. On the basis of these it was possible to conclude that only a small proportion of protein structures have an unexpected degree of symmetry. Artificially generated 'ideal' folds provided an upper limit on the strength of signal that could be expected from a 'perfectly' repeating compact structure. Unexpectedly, some of the very regular beta-propellor folds attained the same strength but the majority of symmetric structures lay below this region. When native proteins were ranked by the power of their spectrum a wide variety of fold types were seen to score highly. In the betaalpha class, these included the globular betaalpha proteins and the more repetitive leucine-rich betaalpha folds. In the all-beta class; beta-propellors, beta-prisms and beta-helices were found as well as the more globular gamma-crystalin domains. When this ranked list was filtered to remove proteins that contained detectable internal sequence similarity (using the program REPRO), the list became exclusively composed of just globular betaalpha class proteins and in the top 50 re-ranked proteins, only a single 4-fold propellor structure remained. PMID:11917144

  1. Combined analysis of C-18 unsaturated fatty acids using natural abundance deuterium 2D NMR spectroscopy in chiral oriented solvents.

    PubMed

    Lesot, Philippe; Baillif, Vincent; Billault, Isabelle

    2008-04-15

    The quantitative determination of isotopic (2H/1H)i ratios at natural abundance using the SNIF-NMR protocol is a well-known method for understanding the enzymatic biosynthesis of metabolites. However, this approach is not always successful for analyzing large solutes and, specifically, is inadequate for prochiral molecules such as complete essential unsaturated fatty acids. To overcome these analytical limitations, we use the natural abundance deuterium 2D NMR (NAD 2D NMR) spectroscopy on solutes embedded in polypeptide chiral liquid crystals. This approach, recently explored for measuring (2H/1H)i ratios of small analytes (Lesot, P.; Aroulanda, C.; Billault, I. Anal. Chem. 2004, 76, 2827-2835), is a powerful way to separate the 2H signals of all nonequivalent enantioisotopomers on the basis both of the 2H quadrupolar interactions and of the 2H chemical shift. Two significant advances over our previous work are presented here and allow the complete isotopic analysis of four mono- and polyunsaturated fatty acid methyl esters: methyl oleate (1), methyl linoleate (2), methyl linolenate (3), and methyl vernoleate (4). The first consists of using NMR spectrometers operating at higher magnetic field strength (14.1 T) and equipped with a selective cryoprobe optimized for deuterium nuclei. The second is the development of Q-COSY Fz 2D NMR experiments able to produce phased 2H 2D maps after a double Fourier transformation. This combination of modern hardware and efficient NMR sequences provides a unique tool to analyze the (2H/1H)i ratios of large prochiral molecules (C-18) dissolved in organic solutions of poly(gamma-benzyl-L-glutamate) and requires smaller amounts of solute than previous study on fatty acids. For each compound (1-4), all 2H quadrupolar doublets visible in the 2D spectra have been assigned on the basis of 2H chemical shifts, isotopic data obtained from isotropic quantitative NAD NMR, and by an interspectral comparison of the anisotropic NAD spectra of four

  2. Analysis of far-infrared emission Fourier transform spectra

    NASA Technical Reports Server (NTRS)

    Park, J. H.; Carli, B.

    1986-01-01

    An analysis method that uses the nonlinear least-squares fit technique has been developed for emission spectra obtained with a Fourier transform spectrometer. This method is used for the analysis of submillimeter-region atmospheric emission spectra obtained with a balloon-borne FT spectrometer that was carried out as a correlative measurement for the Limb IR Monitor of the Stratosphere (LIMS) satellite experiment. The retrieved mixing ratios of H2O and O3 in the stratosphere from four spectral intervals have standard deviations of about 10 percent, and the average values agree to within 10 percent of corresponding results from the LIMS satellite experiment which used a broadband emission radiometer in the IR region.

  3. Gas emission analysis based on Fourier transformed infrared spectroscopy

    NASA Astrophysics Data System (ADS)

    Shu, Xiaowen; Zhang, Xiaofu; Lian, Xu; Jin, Hui

    2014-12-01

    Solar occultation flux (SOF), a new optical technology to detect the gas based on the traditional Fourier transformed infrared spectroscopy (FTIR) developed quickly recently. In this paper, the system and the data analysis is investigated. First a multilayer transmission model of solar radiation is simulated. Then the retrieval process is illustrated. In the proceeding of the data analysis, the Levenberg-Marquardt non-linear square fitting is used to obtain the gas column concentration and the related emission ratio. After the theory certification, the built up system is conducted in a fertilizer plant in Hefei city .The results show SOF is available in the practice and the retrieved gas column concentration can give important information about the pollution emission and dispersion

  4. CAS2D- NONROTATING BLADE-TO-BLADE, STEADY, POTENTIAL TRANSONIC CASCADE FLOW ANALYSIS CODE

    NASA Technical Reports Server (NTRS)

    Dulikravich, D. S.

    1994-01-01

    An exact, full-potential-equation model for the steady, irrotational, homoentropic, and homoenergetic flow of a compressible, inviscid fluid through a two-dimensional planar cascade together with its appropriate boundary conditions has been derived. The CAS2D computer program numerically solves an artificially time-dependent form of the actual full-potential-equation, providing a nonrotating blade-to-blade, steady, potential transonic cascade flow analysis code. Comparisons of results with test data and theoretical solutions indicate very good agreement. In CAS2D, the governing equation is discretized by using type-dependent, rotated finite differencing and the finite area technique. The flow field is discretized by providing a boundary-fitted, nonuniform computational mesh. This mesh is generated by using a sequence of conformal mapping, nonorthogonal coordinate stretching, and local, isoparametric, bilinear mapping functions. The discretized form of the full-potential equation is solved iteratively by using successive line over relaxation. Possible isentropic shocks are captured by the explicit addition of an artificial viscosity in a conservative form. In addition, a four-level, consecutive, mesh refinement feature makes CAS2D a reliable and fast algorithm for the analysis of transonic, two-dimensional cascade flows. The results from CAS2D are not directly applicable to three-dimensional, potential, rotating flows through a cascade of blades because CAS2D does not consider the effects of the Coriolis force that would be present in the three-dimensional case. This program is written in FORTRAN IV for batch execution and has been implemented on an IBM 370 series computer with a central memory requirement of approximately 200K of 8 bit bytes. The CAS2D program was developed in 1980.

  5. META-ANALYSIS OF CYP2D6 METABOLIZER PHENOTYPE AND METOPROLOL PHARMACOKINETICS

    PubMed Central

    Blake, CM; Kharasch, ED; Schwab, M; Nagele, P

    2013-01-01

    Metoprolol, a commonly prescribed beta-blocker, is primarily metabolized by cytochrome P450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Several smaller studies have shown that metoprolol pharmacokinetics is influenced by CYP2D6 genotype and metabolizer phenotype. To increase robustness of metoprolol pharmacokinetic estimates, a systematic review and meta-analysis of pharmacokinetic studies that administered a single oral dose of immediate release metoprolol was performed. Pooled analysis (n= 264) demonstrated differences in peak plasma metoprolol concentration, area under the concentration-time curve, elimination half-life, and apparent oral clearance that were 2.3-, 4.9-, 2.3-, and 5.9-fold between extensive and poor metabolizers, respectively, and 5.3-, 13-, 2.6-, and 15-fold between ultra-rapid and poor metabolizers (all p<0.001). Enantiomer-specific analysis revealed genotype-dependent enantio-selective metabolism, with nearly 40% greater R- vs S-metoprolol metabolism in ultra-rapid and extensive metabolizers. This study demonstrates a marked effect of CYP2D6 metabolizer phenotype on metoprolol pharmacokinetics and confirms enantiomer specific metabolism of metoprolol. PMID:23665868

  6. Using 2D correlation analysis to enhance spectral information available from highly spatially resolved AFM-IR spectra

    NASA Astrophysics Data System (ADS)

    Marcott, Curtis; Lo, Michael; Hu, Qichi; Kjoller, Kevin; Boskey, Adele; Noda, Isao

    2014-07-01

    The recent combination of atomic force microscopy and infrared spectroscopy (AFM-IR) has led to the ability to obtain IR spectra with nanoscale spatial resolution, nearly two orders-of-magnitude better than conventional Fourier transform infrared (FT-IR) microspectroscopy. This advanced methodology can lead to significantly sharper spectral features than are typically seen in conventional IR spectra of inhomogeneous materials, where a wider range of molecular environments are coaveraged by the larger sample cross section being probed. In this work, two-dimensional (2D) correlation analysis is used to examine position sensitive spectral variations in datasets of closely spaced AFM-IR spectra. This analysis can reveal new key insights, providing a better understanding of the new spectral information that was previously hidden under broader overlapped spectral features. Two examples of the utility of this new approach are presented. Two-dimensional correlation analysis of a set of AFM-IR spectra were collected at 200-nm increments along a line through a nucleation site generated by remelting a small spot on a thin film of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate). There are two different crystalline carbonyl band components near 1720 cm-1 that sequentially disappear before a band at 1740 cm-1 due to more disordered material appears. In the second example, 2D correlation analysis of a series of AFM-IR spectra spaced every 1 μm of a thin cross section of a bone sample measured outward from an osteon center of bone growth. There are many changes in the amide I and phosphate band contours, suggesting changes in the bone structure are occurring as the bone matures.

  7. Multiple-perturbation two-dimensional (2D) correlation analysis for spectroscopic imaging data

    NASA Astrophysics Data System (ADS)

    Shinzawa, Hideyuki; Hashimoto, Kosuke; Sato, Hidetoshi; Kanematsu, Wataru; Noda, Isao

    2014-07-01

    A series of data analysis techniques, including multiple-perturbation two-dimensional (2D) correlation spectroscopy and kernel analysis, were used to demonstrate how these techniques can sort out convoluted information content underlying spectroscopic imaging data. A set of Raman spectra of polymer blends consisting of poly(methyl methacrylate) (PMMA) and polyethylene glycol (PEG) were collected under varying spatial coordinates and subjected to multiple-perturbation 2D correlation analysis and kernel analysis by using the coordinates as perturbation variables. Cross-peaks appearing in asynchronous correlation spectra indicated that the change in the spectral intensity of the free Cdbnd O band of the PMMA band occurs before that of the Cdbnd O⋯Hsbnd O band arising from the molecular interaction between PMMA and PEG. Kernel matrices, generated by carrying out 2D correlation analysis on principal component analysis (PCA) score images, revealed subtle but important discrepancy between the patterns of the images, providing additional interpretation to the PCA in an intuitively understandable manner. Consequently, the results provided apparent spectroscopic evidence that PMMA and PEG in the blends are partially miscible at the molecular level, allowing the PMMAs to respond to the perturbations in different manner.

  8. Higher-order Fourier analysis over finite fields and applications

    NASA Astrophysics Data System (ADS)

    Hatami, Pooya

    Higher-order Fourier analysis is a powerful tool in the study of problems in additive and extremal combinatorics, for instance the study of arithmetic progressions in primes, where the traditional Fourier analysis comes short. In recent years, higher-order Fourier analysis has found multiple applications in computer science in fields such as property testing and coding theory. In this thesis, we develop new tools within this theory with several new applications such as a characterization theorem in algebraic property testing. One of our main contributions is a strong near-equidistribution result for regular collections of polynomials. The densities of small linear structures in subsets of Abelian groups can be expressed as certain analytic averages involving linear forms. Higher-order Fourier analysis examines such averages by approximating the indicator function of a subset by a function of bounded number of polynomials. Then, to approximate the average, it suffices to know the joint distribution of the polynomials applied to the linear forms. We prove a near-equidistribution theorem that describes these distributions for the group F(n/p) when p is a fixed prime. This fundamental fact was previously known only under various extra assumptions about the linear forms or the field size. We use this near-equidistribution theorem to settle a conjecture of Gowers and Wolf on the true complexity of systems of linear forms. Our next application is towards a characterization of testable algebraic properties. We prove that every locally characterized affine-invariant property of functions f : F(n/p) → R with n∈ N, is testable. In fact, we prove that any such property P is proximity-obliviously testable. More generally, we show that any affine-invariant property that is closed under subspace restrictions and has "bounded complexity" is testable. We also prove that any property that can be described as the property of decomposing into a known structure of low

  9. Analysis results from the Los Alamos 2D/3D program

    SciTech Connect

    Boyack, B.E.; Cappiello, M.W.; Harmony, S.C.; Shire, P.R.; Siebe, D.A.

    1987-01-01

    Los Alamos National Laboratory is a participant in the 2D/3D program. Activities conducted at Los Alamos National Laboratory in support of 2D/3D program goals include analysis support of facility design, construction, and operation; provision of boundary and initial conditions for test-facility operations based on analysis of pressurized water reactors; performance of pretest and posttest predictions and analyses; and use of experimental results to validate and assess the single- and multi-dimensional, nonequilibrium features in the Transient Reactor Analysis Code (TRAC). During fiscal year 1987, Los Alamos conducted analytical assessment activities using data from the Slab Core Test Facility, The Cylindrical Core Test Facility, and the Upper Plenum Test Facility. Finally, Los Alamos continued work to provide TRAC improvements. In this paper, Los Alamos activities during fiscal year 1987 will be summarized; several significant accomplishments will be described in more detail to illustrate the work activities at Los Alamos.

  10. Nanoscale Graphene Disk: A Natural Functionally Graded Material-How is Fourier's Law Violated along Radius Direction of 2D Disk.

    PubMed

    Yang, Nuo; Hu, Shiqian; Ma, Dengke; Lu, Tingyu; Li, Baowen

    2015-01-01

    In this Paper, we investigate numerically and analytically the thermal conductivity of nanoscale graphene disks (NGDs), and discussed the possibility to realize functionally graded material (FGM) with only one material, NGDs. Different from previous studies on divergence/non-diffusive of thermal conductivity in nano-structures with different size, we found a novel non-homogeneous (graded) thermal conductivity along the radius direction in a single nano-disk structure. We found that, instead of a constant value, the NGD has a graded thermal conductivity along the radius direction. That is, Fourier's law of heat conduction is not valid in two dimensional graphene disk structures Moreover, we show the dependent of NGDs' thermal conductivity on radius and temperature. Our study might inspire experimentalists to develop NGD based versatile FGMs, improve understanding of the heat removal of hot spots on chips, and enhance thermoelectric energy conversion efficiency by two dimensional disk with a graded thermal conductivity. PMID:26443206

  11. Image-based RSA: Roentgen stereophotogrammetric analysis based on 2D-3D image registration.

    PubMed

    de Bruin, P W; Kaptein, B L; Stoel, B C; Reiber, J H C; Rozing, P M; Valstar, E R

    2008-01-01

    Image-based Roentgen stereophotogrammetric analysis (IBRSA) integrates 2D-3D image registration and conventional RSA. Instead of radiopaque RSA bone markers, IBRSA uses 3D CT data, from which digitally reconstructed radiographs (DRRs) are generated. Using 2D-3D image registration, the 3D pose of the CT is iteratively adjusted such that the generated DRRs resemble the 2D RSA images as closely as possible, according to an image matching metric. Effectively, by registering all 2D follow-up moments to the same 3D CT, the CT volume functions as common ground. In two experiments, using RSA and using a micromanipulator as gold standard, IBRSA has been validated on cadaveric and sawbone scapula radiographs, and good matching results have been achieved. The accuracy was: |mu |< 0.083 mm for translations and |mu| < 0.023 degrees for rotations. The precision sigma in x-, y-, and z-direction was 0.090, 0.077, and 0.220 mm for translations and 0.155 degrees , 0.243 degrees , and 0.074 degrees for rotations. Our results show that the accuracy and precision of in vitro IBRSA, performed under ideal laboratory conditions, are lower than in vitro standard RSA but higher than in vivo standard RSA. Because IBRSA does not require radiopaque markers, it adds functionality to the RSA method by opening new directions and possibilities for research, such as dynamic analyses using fluoroscopy on subjects without markers and computer navigation applications. PMID:17706656

  12. Differential Analysis of 2-D Maps by Pixel-Based Approaches.

    PubMed

    Marengo, Emilio; Robotti, Elisa; Quasso, Fabio

    2016-01-01

    Two approaches to the analysis of 2-D maps are available: the first one involves a step of spot detection on each gel image; the second one is based instead on the direct differential analysis of 2-D map images, following a pixel-based procedure. Both approaches strongly depend on the proper alignment of the gel images, but the pixel-based approach allows to solve important drawbacks of the spot-volume procedure, i.e., the problem of missing data and of overlapping spots. However, this approach is quite computationally intensive and requires the use of algorithms able to separate the information (i.e., spot-related information) from the background. Here, the most recent pixel-based approaches are described. PMID:26611422

  13. Fluorescence2D: Software for Accelerated Acquisition and Analysis of Two-Dimensional Fluorescence Spectra

    PubMed Central

    Kovrigin, Evgenii L.

    2014-01-01

    The Fluorescence2D is free software that allows analysis of two-dimensional fluorescence spectra obtained using the accelerated “triangular” acquisition schemes. The software is a combination of Python and MATLAB-based programs that perform conversion of the triangular data, display of the two-dimensional spectra, extraction of 1D slices at different wavelengths, and output in various graphic formats. PMID:24984078

  14. Partial differential equation transform — Variational formulation and Fourier analysis

    PubMed Central

    Wang, Yang; Wei, Guo-Wei; Yang, Siyang

    2011-01-01

    Nonlinear partial differential equation (PDE) models are established approaches for image/signal processing, data analysis and surface construction. Most previous geometric PDEs are utilized as low-pass filters which give rise to image trend information. In an earlier work, we introduced mode decomposition evolution equations (MoDEEs), which behave like high-pass filters and are able to systematically provide intrinsic mode functions (IMFs) of signals and images. Due to their tunable time-frequency localization and perfect reconstruction, the operation of MoDEEs is called a PDE transform. By appropriate selection of PDE transform parameters, we can tune IMFs into trends, edges, textures, noise etc., which can be further utilized in the secondary processing for various purposes. This work introduces the variational formulation, performs the Fourier analysis, and conducts biomedical and biological applications of the proposed PDE transform. The variational formulation offers an algorithm to incorporate two image functions and two sets of low-pass PDE operators in the total energy functional. Two low-pass PDE operators have different signs, leading to energy disparity, while a coupling term, acting as a relative fidelity of two image functions, is introduced to reduce the disparity of two energy components. We construct variational PDE transforms by using Euler-Lagrange equation and artificial time propagation. Fourier analysis of a simplified PDE transform is presented to shed light on the filter properties of high order PDE transforms. Such an analysis also offers insight on the parameter selection of the PDE transform. The proposed PDE transform algorithm is validated by numerous benchmark tests. In one selected challenging example, we illustrate the ability of PDE transform to separate two adjacent frequencies of sin(x) and sin(1.1x). Such an ability is due to PDE transform’s controllable frequency localization obtained by adjusting the order of PDEs. The

  15. Gas Analysis by Fourier Transform Mm-Wave Spectroscopy

    NASA Astrophysics Data System (ADS)

    Harris, Brent J.; Steber, Amanda L.; Lehmann, Kevin K.; Pate, Brooks H.

    2013-06-01

    Molecular rotational spectroscopy of low pressure, room temperature gases offers high chemical selectivity and sensitivity with the potential for a wide range of applications in gas analysis. A strength of the technique is the potential to identify molecules that have not been previously studied by rotational spectroscopy by comparing experimental results to predictions of the spectroscopic parameters from quantum chemistry -6 so called library-free detection. The development of Fourier transform mm-wave spectrometers using high peak power (30 mW) active multiplier chain mm-wave sources brings new measurement capabilities to the analysis of complex gas mixtures. Strategies for gas analysis based on high-throughput mm-wave spectroscopy and arbitrary waveform generator driven mm-wave sources are described. Several new measurement capabilities come from the intrinsic time-domain measurement technique. High-sensitivity double-resonance measurements can be performed to speed the analysis of a complex gas sample containing several species. This technique uses a "pi-pulse" to selectively invert the population of two selected rotational energy levels and the effect of this excitation pulse on all other transitions in the spectrometer operating range is monitored using segmented chirped-pulse Fourier transform spectroscopy. This method can lead to automated determination of the molecular rotational constants. Rapid pulse duration scan experiments can be used to estimate the magnitude and direction of the dipole moment of the molecule from an unknown spectrum. Coherent pulse echo experiments, using the traditional Hahn sequence or two-color population recovery methods, can be used to determine the collisional relaxation rate of the unknown molecule. This rate determination improves the ability to estimate the mass of the unknown molecule from the determination of the Doppler dephasing rate. By performing a suite of automated, high-throughput measurements, there is the

  16. 2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma

    PubMed Central

    Armignacco, Roberta; Ercolino, Tonino; Canu, Letizia; Baroni, Gianna; Nesi, Gabriella; Galli, Andrea; Mannelli, Massimo; Luconi, Michaela

    2015-01-01

    Adrenocortical carcinoma (ACC) is a rare aggressive tumor with poor prognosis when metastatic at diagnosis. The tumor biology is still mostly unclear, justifying the limited specificity and efficacy of the anti-cancer drugs currently available. This study reports the first proteomic analysis of ACC by using two-dimensional-differential-in-gel-electrophoresis (2D-DIGE) to evaluate a differential protein expression profile between adrenocortical carcinoma and normal adrenal. Mass spectrometry, associated with 2D-DIGE analysis of carcinomas and normal adrenals, identified 22 proteins in 27 differentially expressed 2D spots, mostly overexpressed in ACC. Gene ontology analysis revealed that most of the proteins concurs towards a metabolic shift, called the Warburg effect, in adrenocortical cancer. The differential expression was validated by Western blot for Aldehyde-dehydrogenase-6-A1,Transferrin, Fascin-1,Lamin A/C,Adenylate-cyclase-associated-protein-1 and Ferredoxin-reductase. Moreover, immunohistochemistry performed on paraffin-embedded ACC and normal adrenal specimens confirmed marked positive staining for all 6 proteins diffusely expressed by neoplastic cells, compared with normal adrenal cortex. In conclusion, our preliminary findings reveal a different proteomic profile in adrenocortical carcinoma compared with normal adrenal cortex characterized by overexpression of mainly metabolic enzymes, thus suggesting the Warburg effect also occurs in ACC. These proteins may represent promising novel ACC biomarkers and potential therapeutic targets if validated in larger cohorts of patients. PMID:25691058

  17. Error analysis for the Fourier domain offset estimation algorithm

    NASA Astrophysics Data System (ADS)

    Wei, Ling; He, Jieling; He, Yi; Yang, Jinsheng; Li, Xiqi; Shi, Guohua; Zhang, Yudong

    2016-02-01

    The offset estimation algorithm is crucial for the accuracy of the Shack-Hartmann wave-front sensor. Recently, the Fourier Domain Offset (FDO) algorithm has been proposed for offset estimation. Similar to other algorithms, the accuracy of FDO is affected by noise such as background noise, photon noise, and 'fake' spots. However, no adequate quantitative error analysis has been performed for FDO in previous studies, which is of great importance for practical applications of the FDO. In this study, we quantitatively analysed how the estimation error of FDO is affected by noise based on theoretical deduction, numerical simulation, and experiments. The results demonstrate that the standard deviation of the wobbling error is: (1) inversely proportional to the raw signal to noise ratio, and proportional to the square of the sub-aperture size in the presence of background noise; and (2) proportional to the square root of the intensity in the presence of photonic noise. Furthermore, the upper bound of the estimation error is proportional to the intensity of 'fake' spots and the sub-aperture size. The results of the simulation and experiments agreed with the theoretical analysis.

  18. Multiple triangulation analysis: application to determine the velocity of 2-D structures

    NASA Astrophysics Data System (ADS)

    Zhou, X.-Z.; Zong, Q.-G.; Wang, J.; Pu, Z. Y.; Zhang, X. G.; Shi, Q. Q.; Cao, J. B.

    2006-11-01

    In order to avoid the ambiguity of the application of the Triangulation Method (multi-spacecraft timing method) to two-dimensional structures, another version of this method, the Multiple Triangulation Analysis (MTA) is used, to calculate the velocities of these structures based on 4-point measurements. We describe the principle of MTA and apply this approach to a real event observed by the Cluster constellation on 2 October 2003. The resulting velocity of the 2-D structure agrees with the ones obtained by some other methods fairly well. So we believe that MTA is a reliable version of the Triangulation Method for 2-D structures, and thus provides us a new way to describe their motion.

  19. Human factors flight trial analysis for 2D/3D SVS

    NASA Astrophysics Data System (ADS)

    Schiefele, Jens; Howland, Duncan; Maris, John; Wipplinger, Patrick

    2004-08-01

    The paper describes flight trials performed in Reno, NV. Flight trial were conducted with a Cheyenne 1 from Marinvent. Twelve pilots flew the Cheyenne in seventy-two approaches to the Reno airfield. All pilots flew completely andomized settings. Three different settings (standard displays, 2D moving map, and 2D/3D moving map) were evaluated. They included seamless evaluation for STAR, approach, and taxi operations. The flight trial goal was to evaluate the objective performance of pilots compared among the different settings. As dependent variables, positional and time accuracy were measured. Analysis was conducted by an ANOVA test. In parallel, all pilots answered subjective Cooper-Harper, situation awareness rating technique (SART), situational awareness probe (SAP), and questionnaires.This article describes the human factor analysis from flight trials performed in Reno, NV. Flight trials were conducted with a Cheyenne 1 from Marinvent. Thirteen pilots flew the Cheyenne in seventy-two approaches to the Reno airfield. All pilots flew completely randomized settings. Three different display configurations: Elec. Flight Information System (EFIS), EFIS and 2D moving map, and 3D SVS Primary Flight Display (PFD) and 2D moving map were evaluated. They included normal/abnormal procedure evaluation for: Steep turns and reversals, Unusual attitude recovery, Radar vector guidance towards terrain, Non-precision approaches, En-route alternate for non-IFR rated pilots encountering IMC, and Taxiing on complex taxi-routes. The flight trial goal was to evaluate the objective performance of pilots for the different display configurations. As dependent variables, positional and time data were measured. Analysis was performed by an ANOVA test. In parallel, all pilots answered subjective NASA Task Load Index, Cooper-Harper, Situation Awareness Rating Technique (SART), and questionnaires. The result shows that pilots flying 2D/3D SVS perform no worse than pilots with conventional

  20. FOURIER ANALYSIS OF EXTENDED FINE STRUCTURE WITH AUTOREGRESSIVE PREDICTION

    SciTech Connect

    Barton, J.; Shirley, D.A.

    1985-01-01

    Autoregressive prediction is adapted to double the resolution of Angle-Resolved Photoemission Extended Fine Structure (ARPEFS) Fourier transforms. Even with the optimal taper (weighting function), the commonly used taper-and-transform Fourier method has limited resolution: it assumes the signal is zero beyond the limits of the measurement. By seeking the Fourier spectrum of an infinite extent oscillation consistent with the measurements but otherwise having maximum entropy, the errors caused by finite data range can be reduced. Our procedure developed to implement this concept applies autoregressive prediction to extrapolate the signal to an extent controlled by a taper width. Difficulties encountered when processing actual ARPEFS data are discussed. A key feature of this approach is the ability to convert improved measurements (signal-to-noise or point density) into improved Fourier resolution.

  1. HIGH RESOLUTION FOURIER ANALYSIS WITH AUTO-REGRESSIVE LINEAR PREDICTION

    SciTech Connect

    Barton, J.; Shirley, D.A.

    1984-04-01

    Auto-regressive linear prediction is adapted to double the resolution of Angle-Resolved Photoemission Extended Fine Structure (ARPEFS) Fourier transforms. Even with the optimal taper (weighting function), the commonly used taper-and-transform Fourier method has limited resolution: it assumes the signal is zero beyond the limits of the measurement. By seeking the Fourier spectrum of an infinite extent oscillation consistent with the measurements but otherwise having maximum entropy, the errors caused by finite data range can be reduced. Our procedure developed to implement this concept adapts auto-regressive linear prediction to extrapolate the signal in an effective and controllable manner. Difficulties encountered when processing actual ARPEFS data are discussed. A key feature of this approach is the ability to convert improved measurements (signal-to-noise or point density) into improved Fourier resolution.

  2. Cutoff probe using Fourier analysis for electron density measurement

    NASA Astrophysics Data System (ADS)

    Na, Byung-Keun; You, Kwang-Ho; Kim, Dae-Woong; Chang, Hong-Young; You, Shin-Jae; Kim, Jung-Hyung

    2012-01-01

    This paper proposes a new method for cutoff probe using a nanosecond impulse generator and an oscilloscope, instead of a network analyzer. The nanosecond impulse generator supplies a radiating signal of broadband frequency spectrum simultaneously without frequency sweeping, while frequency sweeping method is used by a network analyzer in a previous method. The transmission spectrum (S21) was obtained through a Fourier analysis of the transmitted impulse signal detected by the oscilloscope and was used to measure the electron density. The results showed that the transmission frequency spectrum and the electron density obtained with a new method are very close to those obtained with a previous method using a network analyzer. And also, only 15 ns long signal was necessary for spectrum reconstruction. These results were also compared to the Langmuir probe's measurements with satisfactory results. This method is expected to provide not only fast measurement of absolute electron density, but also function in other diagnostic situations where a network analyzer would be used (a hairpin probe and an impedance probe) by replacing the network analyzer with a nanosecond impulse generator and an oscilloscope.

  3. On the Fourier and Wavelet Analysis of Coronal Time Series

    NASA Astrophysics Data System (ADS)

    Auchère, F.; Froment, C.; Bocchialini, K.; Buchlin, E.; Solomon, J.

    2016-07-01

    Using Fourier and wavelet analysis, we critically re-assess the significance of our detection of periodic pulsations in coronal loops. We show that the proper identification of the frequency dependence and statistical properties of the different components of the power spectra provides a strong argument against the common practice of data detrending, which tends to produce spurious detections around the cut-off frequency of the filter. In addition, the white and red noise models built into the widely used wavelet code of Torrence & Compo cannot, in most cases, adequately represent the power spectra of coronal time series, thus also possibly causing false positives. Both effects suggest that several reports of periodic phenomena should be re-examined. The Torrence & Compo code nonetheless effectively computes rigorous confidence levels if provided with pertinent models of mean power spectra, and we describe the appropriate manner in which to call its core routines. We recall the meaning of the default confidence levels output from the code, and we propose new Monte-Carlo-derived levels that take into account the total number of degrees of freedom in the wavelet spectra. These improvements allow us to confirm that the power peaks that we detected have a very low probability of being caused by noise.

  4. Fourier analysis of polar cap electric field and current distributions

    NASA Technical Reports Server (NTRS)

    Barbosa, D. D.

    1984-01-01

    A theoretical study of high-latitude electric fields and currents, using analytic Fourier analysis methods, is conducted. A two-dimensional planar model of the ionosphere with an enhanced conductivity auroral belt and field-aligned currents at the edges is employed. Two separate topics are treated. A field-aligned current element near the cusp region of the polar cap is included to investigate the modifications to the convection pattern by the east-west component of the interplanetary magnetic field. It is shown that a sizable one-cell structure is induced near the cusp which diverts equipotential contours to the dawnside or duskside, depending on the sign of the cusp current. This produces characteristic dawn-dusk asymmetries to the electric field that have been previously observed over the polar cap. The second topic is concerned with the electric field configuration obtained in the limit of perfect shielding, where the field is totally excluded equatorward of the auroral oval. When realistic field-aligned current distributions are used, the result is to produce severely distorted, crescent-shaped equipotential contours over the cap. Exact, analytic formulae applicable to this case are also provided.

  5. Real-time 2D spatially selective MRI experiments: Comparative analysis of optimal control design methods

    NASA Astrophysics Data System (ADS)

    Maximov, Ivan I.; Vinding, Mads S.; Tse, Desmond H. Y.; Nielsen, Niels Chr.; Shah, N. Jon

    2015-05-01

    There is an increasing need for development of advanced radio-frequency (RF) pulse techniques in modern magnetic resonance imaging (MRI) systems driven by recent advancements in ultra-high magnetic field systems, new parallel transmit/receive coil designs, and accessible powerful computational facilities. 2D spatially selective RF pulses are an example of advanced pulses that have many applications of clinical relevance, e.g., reduced field of view imaging, and MR spectroscopy. The 2D spatially selective RF pulses are mostly generated and optimised with numerical methods that can handle vast controls and multiple constraints. With this study we aim at demonstrating that numerical, optimal control (OC) algorithms are efficient for the design of 2D spatially selective MRI experiments, when robustness towards e.g. field inhomogeneity is in focus. We have chosen three popular OC algorithms; two which are gradient-based, concurrent methods using first- and second-order derivatives, respectively; and a third that belongs to the sequential, monotonically convergent family. We used two experimental models: a water phantom, and an in vivo human head. Taking into consideration the challenging experimental setup, our analysis suggests the use of the sequential, monotonic approach and the second-order gradient-based approach as computational speed, experimental robustness, and image quality is key. All algorithms used in this work were implemented in the MATLAB environment and are freely available to the MRI community.

  6. Real-time 2D spatially selective MRI experiments: Comparative analysis of optimal control design methods.

    PubMed

    Maximov, Ivan I; Vinding, Mads S; Tse, Desmond H Y; Nielsen, Niels Chr; Shah, N Jon

    2015-05-01

    There is an increasing need for development of advanced radio-frequency (RF) pulse techniques in modern magnetic resonance imaging (MRI) systems driven by recent advancements in ultra-high magnetic field systems, new parallel transmit/receive coil designs, and accessible powerful computational facilities. 2D spatially selective RF pulses are an example of advanced pulses that have many applications of clinical relevance, e.g., reduced field of view imaging, and MR spectroscopy. The 2D spatially selective RF pulses are mostly generated and optimised with numerical methods that can handle vast controls and multiple constraints. With this study we aim at demonstrating that numerical, optimal control (OC) algorithms are efficient for the design of 2D spatially selective MRI experiments, when robustness towards e.g. field inhomogeneity is in focus. We have chosen three popular OC algorithms; two which are gradient-based, concurrent methods using first- and second-order derivatives, respectively; and a third that belongs to the sequential, monotonically convergent family. We used two experimental models: a water phantom, and an in vivo human head. Taking into consideration the challenging experimental setup, our analysis suggests the use of the sequential, monotonic approach and the second-order gradient-based approach as computational speed, experimental robustness, and image quality is key. All algorithms used in this work were implemented in the MATLAB environment and are freely available to the MRI community. PMID:25863895

  7. 2D optical array probe analysis of precipitating cumulonimbus clouds during EPIC 2001

    NASA Astrophysics Data System (ADS)

    Baumgardner, D.; Raga, G. B.

    2007-05-01

    During the 2001 East Pacific Investigation of Climate (EPIC) experiment, numerous measurements were made of the size distributions of raindrops in convective clouds that were developing over a region of the Mexican inter- tropical convergence zone (ITCZ). These measurements were made with optical array probes (PMS 2D-C and 2D-P) mounted on the National Science Foundation Hercules C-130, operated by the National Center for Atmospheric Research. In addition to capturing shadow images of individual drops between 25 μm and 6400 μm, these instruments also record the distance between each drop via a measurement of arrival times in the spectrometers lasers. The separation distance, along with the drop size, provides detailed information about the microstructure of precipitation. The 2D probe measurements have been analyzed as a function of altitude above cloud base, horizontal distance from cloud edges, cloud droplet size distributions (2-50 μm) and vertical wind velocities. The objective of the analysis is to evaluate the spatial distribution of precipitation events with respect to the microphysical and dynamical processes that are related to the development and evolution of rain in tropical convective clouds. In addition, the reflectivity is calculated from the size distributions and evaluated to assess how inhomogeneities in the precipitation might be observed by meteorological radars.

  8. Analysis results from the Los Alamos 2D/3D program

    SciTech Connect

    Boyack, B.E.; Cappiello, M.W.; Stumpf, H.; Shire, P.; Gilbert, J.; Hedstrom, J.

    1986-01-01

    Los Alamos National Laboratory is a participant in the 2D/3D program. Activities conducted at Los Alamos National Laboratory in support of 2D/3D program goals include analysis support of facility design, construction, and operation; provision of boundary and initial conditions for test facility operations based on analysis of pressurized water reactors; performance of pretest and posttest predictions and analyses; and use of experimental results to validate and assess the single- and multidimensional nonequilibrium features in the Transient Reactor Analysis Code (TRAC). During Fiscal Year 1986, Los Alamos conducted analytical assessment activities using data from the Cylindrical Core Test Facility and the Slab Core Test Facility. Los Alamos also continued to provide support analysis for the planning of Upper Plenum Test Facility experiments. Finally, Los Alamos either completed or is currently working on three areas of TRAC modeling improvement. In this paper, Los Alamos activities during Fiscal Year 1986 are summarized; several significant accomplishments are described in more detail to illustrate the work activities at Los Alamos.

  9. Parametric analysis of 2D guided-wave photonic band gap structures

    NASA Astrophysics Data System (ADS)

    Ciminelli, C.; Peluso, F.; Armenise, M. N.

    2005-11-01

    The parametric analysis of the electromagnetic properties of 2D guided wave photonic band gap structures is reported with the aim of providing a valid tool for the optimal design. The modelling approach is based on the Bloch-Floquet method. Different lattice configurations and geometrical parameters are considered. An optimum value for the ratio between the hole (or rod) radius and the lattice constant does exist and the calculation demonstrated that it is almost independent from the etching depth, only depending on the lattice type. The results are suitable for the design optimisation of photonic crystal reflectors to be used in integrated optical devices.

  10. Parametric analysis of 2D guided-wave photonic band gap structures.

    PubMed

    Ciminelli, C; Peluso, F; Armenise, M

    2005-11-28

    The parametric analysis of the electromagnetic properties of 2D guided wave photonic band gap structures is reported with the aim of providing a valid tool for the optimal design. The modelling approach is based on the Bloch-Floquet method. Different lattice configurations and geometrical parameters are considered. An optimum value for the ratio between the hole (or rod) radius and the lattice constant does exist and the calculation demonstrated that it is almost independent from the etching depth, only depending on the lattice type. The results are suitable for the design optimisation of photonic crystal reflectors to be used in integrated optical devices. PMID:19503180

  11. A scaling analysis of the superconducting fluctuations in 2D InOx thin films

    NASA Astrophysics Data System (ADS)

    Liu, Wei; Kim, Minsoo; Wu, Tai-Lung; Ganapathy, Sambandamurthy; Armitage, Peter

    2010-03-01

    We apply a broadband microwave Corbino spectrometer covering the range from 10MHz to 20GHz to the study of 2D disordered superconducting InOx thin films. Explicit frequency dependency of the superfluid stiffness and conductivity are obtained down to 300mK. Via vacuum annealing, we investigate a broad range of disorder levels and transition temperatures in a single film. We perform a scaling analysis in which we can extract characteristic relaxation time of superconducting fluctuations. We discuss our results in terms of prevailing scenarios for fluctuation superconductivity and make connection to other experimental results.

  12. Combining 2D synchrosqueezed wave packet transform with optimization for crystal image analysis

    NASA Astrophysics Data System (ADS)

    Lu, Jianfeng; Wirth, Benedikt; Yang, Haizhao

    2016-04-01

    We develop a variational optimization method for crystal analysis in atomic resolution images, which uses information from a 2D synchrosqueezed transform (SST) as input. The synchrosqueezed transform is applied to extract initial information from atomic crystal images: crystal defects, rotations and the gradient of elastic deformation. The deformation gradient estimate is then improved outside the identified defect region via a variational approach, to obtain more robust results agreeing better with the physical constraints. The variational model is optimized by a nonlinear projected conjugate gradient method. Both examples of images from computer simulations and imaging experiments are analyzed, with results demonstrating the effectiveness of the proposed method.

  13. Fixed-point error analysis of Winograd Fourier transform algorithms

    NASA Technical Reports Server (NTRS)

    Patterson, R. W.; Mcclellan, J. H.

    1978-01-01

    The quantization error introduced by the Winograd Fourier transform algorithm (WFTA) when implemented in fixed-point arithmetic is studied and compared with that of the fast Fourier transform (FFT). The effect of ordering the computational modules and the relative contributions of data quantization error and coefficient quantization error are determined. In addition, the quantization error introduced by the Good-Winograd (GW) algorithm, which uses Good's prime-factor decomposition for the discrete Fourier transform (DFT) together with Winograd's short length DFT algorithms, is studied. Error introduced by the WFTA is, in all cases, worse than that of the FFT. In general, the WFTA requires one or two more bits for data representation to give an error similar to that of the FFT. Error introduced by the GW algorithm is approximately the same as that of the FFT.

  14. Automatic inspection of density in yarn-dyed fabrics by utilizing fabric light transmittance and Fourier analysis.

    PubMed

    Zhang, Jie; Pan, Ruru; Gao, Weidong

    2015-02-01

    Yarn density measurement is a significant part of yarn-dyed fabric analysis, traditionally based on reflective image analysis. In this paper, utilizing fabric light transmittance, a method for two-dimensional discrete Fourier transform (2D DFT) analysis on the transmission fabric image is developed for fabric density inspection. First, the power spectrum is generated from the fabric image by a 2D DFT. Next, the yarn skew angles are detected based on the power spectrum analysis. Then the fabric image is reconstructed by an inverse 2D DFT. Finally, projection curves are generated from the reconstructed images and the number of yarns is counted according to the peaks and valleys to obtain the fabric density. Through a comparison between analysis on the reflective and transmission images of multiple-color fabrics, it is proved that the latter method can segment the yarns with more satisfactory accuracy. Furthermore, the experimental and theoretical analyses demonstrate that the proposed method is effective for the density inspection of yarn-dyed fabrics with good robustness and great accuracy. PMID:25967813

  15. HPLC analysis of discrete haptoglobin isoform N-linked oligosaccharides following 2D-PAGE isolation.

    PubMed

    He, Zhicong; Aristoteli, Lina P; Kritharides, Leonard; Garner, Brett

    2006-05-01

    Glycosylation is a common but variable modification that regulates glycoprotein structure and function. We combined small format 2D-PAGE with HPLC to analyse discrete human haptoglobin isoform N-glycans. Seven major and several minor haptoglobin isoforms were detected by 2D-PAGE. N-Glycans released from Coomassie-stained gel spots using PNGase were labeled at their reducing termini with 2-aminobenzamide. HPLC analysis of selected major isoform N-glycans indicated that sialic acid composition determined their separation by isoelectric focussing. N-Glycans from two doublets of quantitatively minor isoforms were also analysed. Although separation of each pair of doublets was influenced by sialylation, individual spots within each doublet contained identical N-glycans. Thus, heterogeneity in minor haptoglobin isoforms was due to modifications distinct from N-glycan structure. These studies describe a simple method for analysing low abundance protein N-glycans and provide details of discrete haptoglobin isoform N-glycan structures which will be useful in proteomic analysis of human plasma samples. PMID:16546121

  16. 2D light scattering static cytometry for label-free single cell analysis with submicron resolution.

    PubMed

    Xie, Linyan; Yang, Yan; Sun, Xuming; Qiao, Xu; Liu, Qiao; Song, Kun; Kong, Beihua; Su, Xuantao

    2015-11-01

    Conventional optical cytometric techniques usually measure fluorescence or scattering signals at fixed angles from flowing cells in a liquid stream. Here we develop a novel cytometer that employs a scanning optical fiber to illuminate single static cells on a glass slide, which requires neither microfluidic fabrication nor flow control. This static cytometric technique measures two dimensional (2D) light scattering patterns via a small numerical aperture (0.25) microscope objective for label-free single cell analysis. Good agreement is obtained between the yeast cell experimental and Mie theory simulated patterns. It is demonstrated that the static cytometer with a microscope objective of a low resolution around 1.30 μm has the potential to perform high resolution analysis on yeast cells with distributed sizes. The capability of the static cytometer for size determination with submicron resolution is validated via measurements on standard microspheres with mean diameters of 3.87 and 4.19 μm. Our 2D light scattering static cytometric technique may provide an easy-to-use, label-free, and flow-free method for single cell diagnostics. PMID:26115102

  17. Infinitesimal-area 2D radiative analysis using parametric surface representation, through NURBS

    SciTech Connect

    Daun, K.J.; Hollands, K.G.T.

    1999-07-01

    The use of form factors in the treatment of radiant enclosures requires that the radiosity and surface properties be treated as uniform over finite areas. This restriction can be relaxed by applying an infinitesimal-area analysis, where the radiant exchange is taken to be between infinitesimal areas, rather than finite areas. This paper presents a generic infinitesimal-area formulation that can be applied to two-dimensional enclosure problems. (Previous infinitesimal-area analyses have largely been restricted to specific, one-dimensional problems.) Specifically, the paper shows how the analytical expression for the kernel of the integral equation can be obtained without human intervention, once the enclosure surface has been defined parametrically. This can be accomplished by using a computer algebra package or by using NURBS algorithms, which are the industry standard for the geometrical representations used in CAD-CAM codes. Once the kernel has been obtained by this formalism, the 2D integral equation can be set up and solved numerically. The result is a single general-purpose infinitesimal-area analysis code that can proceed from surface specification to solution. The authors have implemented this 2D code and tested it on 1D problems, whose solutions have been given in the literature, obtaining agreement commensurate with the accuracy of the published solutions.

  18. Lacunarity analysis of raster datasets and 1D, 2D, and 3D point patterns

    NASA Astrophysics Data System (ADS)

    Dong, Pinliang

    2009-10-01

    Spatial scale plays an important role in many fields. As a scale-dependent measure for spatial heterogeneity, lacunarity describes the distribution of gaps within a set at multiple scales. In Earth science, environmental science, and ecology, lacunarity has been increasingly used for multiscale modeling of spatial patterns. This paper presents the development and implementation of a geographic information system (GIS) software extension for lacunarity analysis of raster datasets and 1D, 2D, and 3D point patterns. Depending on the application requirement, lacunarity analysis can be performed in two modes: global mode or local mode. The extension works for: (1) binary (1-bit) and grey-scale datasets in any raster format supported by ArcGIS and (2) 1D, 2D, and 3D point datasets as shapefiles or geodatabase feature classes. For more effective measurement of lacunarity for different patterns or processes in raster datasets, the extension allows users to define an area of interest (AOI) in four different ways, including using a polygon in an existing feature layer. Additionally, directionality can be taken into account when grey-scale datasets are used for local lacunarity analysis. The methodology and graphical user interface (GUI) are described. The application of the extension is demonstrated using both simulated and real datasets, including Brodatz texture images, a Spaceborne Imaging Radar (SIR-C) image, simulated 1D points on a drainage network, and 3D random and clustered point patterns. The options of lacunarity analysis and the effects of polyline arrangement on lacunarity of 1D points are also discussed. Results from sample data suggest that the lacunarity analysis extension can be used for efficient modeling of spatial patterns at multiple scales.

  19. Comparative analysis of feature extraction (2D FFT and wavelet) and classification (Lp metric distances, MLP NN, and HNeT) algorithms for SAR imagery

    NASA Astrophysics Data System (ADS)

    Sandirasegaram, Nicholas; English, Ryan

    2005-05-01

    The performance of several combinations of feature extraction and target classification algorithms is analyzed for Synthetic Aperture Radar (SAR) imagery using the standard Moving and Stationary Target Acquisition and Recognition (MSTAR) evaluation method. For feature extraction, 2D Fast Fourier Transform (FFT) is used to extract Fourier coefficients (frequency information) while 2D wavelet decomposition is used to extract wavelet coefficients (time-frequency information), from which subsets of characteristic in-class "invariant" coefficients are developed. Confusion matrices and Receiver Operating Characteristic (ROC) curves are used to evaluate and compare combinations of these characteristic coefficients with several classification methods, including Lp metric distances, a Multi Layer Perceptron (MLP) Neural Network (NN) and AND Corporation's Holographic Neural Technology (HNeT) classifier. The evaluation method examines the trade-off between correct detection rate and false alarm rate for each combination of feature-classifier systems. It also measures correct classification, misclassification and rejection rates for a 90% detection rate. Our analysis demonstrates the importance of feature and classifier selection in accurately classifying new target images.

  20. Analysis of 2-d ultrasound cardiac strain imaging using joint probability density functions.

    PubMed

    Ma, Chi; Varghese, Tomy

    2014-06-01

    Ultrasound frame rates play a key role for accurate cardiac deformation tracking. Insufficient frame rates lead to an increase in signal de-correlation artifacts resulting in erroneous displacement and strain estimation. Joint probability density distributions generated from estimated axial strain and its associated signal-to-noise ratio provide a useful approach to assess the minimum frame rate requirements. Previous reports have demonstrated that bi-modal distributions in the joint probability density indicate inaccurate strain estimation over a cardiac cycle. In this study, we utilize similar analysis to evaluate a 2-D multi-level displacement tracking and strain estimation algorithm for cardiac strain imaging. The effect of different frame rates, final kernel dimensions and a comparison of radio frequency and envelope based processing are evaluated using echo signals derived from a 3-D finite element cardiac model and five healthy volunteers. Cardiac simulation model analysis demonstrates that the minimum frame rates required to obtain accurate joint probability distributions for the signal-to-noise ratio and strain, for a final kernel dimension of 1 λ by 3 A-lines, was around 42 Hz for radio frequency signals. On the other hand, even a frame rate of 250 Hz with envelope signals did not replicate the ideal joint probability distribution. For the volunteer study, clinical data was acquired only at a 34 Hz frame rate, which appears to be sufficient for radio frequency analysis. We also show that an increase in the final kernel dimensions significantly affect the strain probability distribution and joint probability density function generated, with a smaller effect on the variation in the accumulated mean strain estimated over a cardiac cycle. Our results demonstrate that radio frequency frame rates currently achievable on clinical cardiac ultrasound systems are sufficient for accurate analysis of the strain probability distribution, when a multi-level 2-D

  1. 2D NMR Barcoding and Differential Analysis of Complex Mixtures for Chemical Identification: The Actaea Triterpenes

    PubMed Central

    2015-01-01

    The interpretation of NMR spectroscopic information for structure elucidation involves decoding of complex resonance patterns that contain valuable molecular information (δ and J), which is not readily accessible otherwise. We introduce a new concept of 2D-NMR barcoding that uses clusters of fingerprint signals and their spatial relationships in the δ−δ coordinate space to facilitate the chemical identification of complex mixtures. Similar to widely used general barcoding technology, the structural information of individual compounds is encoded as a specifics pattern of their C,H correlation signals. Software-based recognition of these patterns enables the structural identification of the compounds and their discrimination in mixtures. Using the triterpenes from various Actaea (syn. Cimicifuga) species as a test case, heteronuclear multiple-bond correlation (HMBC) barcodes were generated on the basis of their structural subtypes from a statistical investigation of their δH and δC data in the literature. These reference barcodes allowed in silico identification of known triterpenes in enriched fractions obtained from an extract of A. racemosa (black cohosh). After dereplication, a differential analysis of heteronuclear single-quantum correlation (HSQC) spectra even allowed for the discovery of a new triterpene. The 2D barcoding concept has potential application in a natural product discovery project, allowing for the rapid dereplication of known compounds and as a tool in the search for structural novelty within compound classes with established barcodes. PMID:24673652

  2. Experimental Analysis of a 2-D Lightcraft in Static and Hypersonic Conditions

    NASA Astrophysics Data System (ADS)

    Salvador, Israel I.; Myrabo, Leik N.; Minucci, Marco A. S.; de Oliveira, Antonio C.; Rego, Israel S.; Toro, Paulo G. P.; Channes, José B.

    2010-05-01

    Aiming at the hypersonic phase of the Earth-to-Orbit trajectory for a laser propelled vehicle, a 2-D Lightcraft model was designed to be tested at the T3 Hypersonic Shock Tunnel at the Henry T. Nagamatsu Laboratory for Aerodynamics and Hypersonics. A high energy laser pulse was supplied by a Lumonics TEA 620 laser system operating in unstable resonator cavity mode. The experiments were performed at quiescent (no flow) conditions and at a nominal Mach number of 9.2. A Schlieren visualization apparatus was used in order to access both the cold hypersonic flowfield structure (without laser deposition) and the time dependent flowfield structure, taking place after the laser induced breakdown inside the absorption chamber. The model was fitted with piezoelectric pressure transducers and surface junction thermocouples in an attempt to measure pressure and heat transfer time dependent distributions at the internal surfaces of the model's absorption chamber. The 2-D model followed a modular design for flexibility on the analysis of geometrical features contribution on the expansion of the laser induced blast wave. Finally, future evolution of the experiments being currently pursued is addressed.

  3. 2D NMR barcoding and differential analysis of complex mixtures for chemical identification: the Actaea triterpenes.

    PubMed

    Qiu, Feng; McAlpine, James B; Lankin, David C; Burton, Ian; Karakach, Tobias; Chen, Shao-Nong; Pauli, Guido F

    2014-04-15

    The interpretation of NMR spectroscopic information for structure elucidation involves decoding of complex resonance patterns that contain valuable molecular information (δ and J), which is not readily accessible otherwise. We introduce a new concept of 2D-NMR barcoding that uses clusters of fingerprint signals and their spatial relationships in the δ-δ coordinate space to facilitate the chemical identification of complex mixtures. Similar to widely used general barcoding technology, the structural information of individual compounds is encoded as a specifics pattern of their C,H correlation signals. Software-based recognition of these patterns enables the structural identification of the compounds and their discrimination in mixtures. Using the triterpenes from various Actaea (syn. Cimicifuga) species as a test case, heteronuclear multiple-bond correlation (HMBC) barcodes were generated on the basis of their structural subtypes from a statistical investigation of their δH and δC data in the literature. These reference barcodes allowed in silico identification of known triterpenes in enriched fractions obtained from an extract of A. racemosa (black cohosh). After dereplication, a differential analysis of heteronuclear single-quantum correlation (HSQC) spectra even allowed for the discovery of a new triterpene. The 2D barcoding concept has potential application in a natural product discovery project, allowing for the rapid dereplication of known compounds and as a tool in the search for structural novelty within compound classes with established barcodes. PMID:24673652

  4. Using musical intervals to demonstrate superposition of waves and Fourier analysis

    NASA Astrophysics Data System (ADS)

    LoPresto, Michael C.

    2013-09-01

    What follows is a description of a demonstration of superposition of waves and Fourier analysis using a set of four tuning forks mounted on resonance boxes and oscilloscope software to create, capture and analyze the waveforms and Fourier spectra of musical intervals.

  5. Using Musical Intervals to Demonstrate Superposition of Waves and Fourier Analysis

    ERIC Educational Resources Information Center

    LoPresto, Michael C.

    2013-01-01

    What follows is a description of a demonstration of superposition of waves and Fourier analysis using a set of four tuning forks mounted on resonance boxes and oscilloscope software to create, capture and analyze the waveforms and Fourier spectra of musical intervals.

  6. Transfer function analysis in epi-illumination Fourier ptychography

    PubMed Central

    Pacheco, Shaun; Salahieh, Basel; Milster, Tom; Rodriguez, Jeffrey J.; Liang, Rongguang

    2016-01-01

    This letter explores Fourier ptychography (FP) using epi-illumination. The approach effectively modifies the FP transfer function to be coherent-like out to the incoherent limit of twice the numerical aperture over the wavelength 2NA/λ. Images reconstructed using this approach are shown to have higher contrast at finer details compared with images using incoherent illumination, indicating that the FP transfer function is superior in high spatial frequency regions. PMID:26565870

  7. [Analysis of streamer properties and emission spectroscopy of 2-D OH distribution of pulsed corona discharge].

    PubMed

    Zhao, Lei; Gao, Xiang; Luo, Zhong-Yang; Xuan, Jian-Yong; Jiang, Jian-Ping; Cen, Ke-Fa

    2011-11-01

    Streamer plays a key role in the process of OH radical generation. The propagation of primary and secondary streamers of positive wire-plate pulsed corona discharge was observed using a short gate ICCD in air environment. The influence of the applied voltage on the properties was investigated. It was shown that the primary streamer propagation velocity, electric coverage and length of secondary streamer increased significantly with increasing the applied voltage. Then 2-D OH distribution was investigated by the emission spectrum. With the analysis of the OH emission spectra, the distribution of OH radicals showed a trend of decreasing from the wire electrode to its circumambience. Compared with the streamer propagation trace, the authors found that OH radical distribution and streamer are in the same area. Both OH radical concentration and the intensity of streamer decreased when far away from the wire electrode. PMID:22242481

  8. Optical fiber poling by induction: analysis by 2D numerical modeling.

    PubMed

    De Lucia, F; Huang, D; Corbari, C; Healy, N; Sazio, P J A

    2016-04-15

    Since their first demonstration some 25 years ago, thermally poled silica fibers have been used to realize device functions such as electro-optic modulation, switching, polarization-entangled photons, and optical frequency conversion with a number of advantages over bulk free-space components. We have recently developed an innovative induction poling technique that could allow for the development of complex microstructured fiber geometries for highly efficient χ(2)-based device applications. To systematically implement these more advanced poled fiber designs, we report here the development of comprehensive numerical models of the induction poling mechanism itself via two-dimensional (2D) simulations of ion migration and space-charge region formation using finite element analysis. PMID:27082323

  9. Numerical method of crack analysis in 2D finite magnetoelectroelastic media

    NASA Astrophysics Data System (ADS)

    Zhao, Minghao; Xu, Guangtao; Fan, Cuiying

    2010-04-01

    The present paper extends the hybrid extended displacement discontinuity fundamental solution method (HEDD-FSM) (Eng Anal Bound Elem 33:592-600, 2009) to analysis of cracks in 2D finite magnetoelectroelastic media. The solution of the crack is expressed approximately by a linear combination of fundamental solutions of the governing equations, which includes the extended point force fundamental solutions with sources placed at chosen points outside the domain of the problem under consideration, and the extended Crouch fundamental solutions with extended displacement discontinuities placed on the crack. The coefficients of the fundamental solutions are determined by letting the approximated solution satisfy the prescribed boundary conditions on the boundary of the domain and on the crack face. The Crouch fundamental solution for a parabolic element at the crack tip is derived to model the square root variations of near tip fields. The extended stress intensity factors are calculated under different electric and magnetic boundary conditions.

  10. Interfractional trend analysis of dose differences based on 2D transit portal dosimetry

    NASA Astrophysics Data System (ADS)

    Persoon, L. C. G. G.; Nijsten, S. M. J. J. G.; Wilbrink, F. J.; Podesta, M.; Snaith, J. A. D.; Lustberg, T.; van Elmpt, W. J. C.; van Gils, F.; Verhaegen, F.

    2012-10-01

    Dose delivery of a radiotherapy treatment can be influenced by a number of factors. It has been demonstrated that the electronic portal imaging device (EPID) is valuable for transit portal dosimetry verification. Patient related dose differences can emerge at any time during treatment and can be categorized in two types: (1) systematic—appearing repeatedly, (2) random—appearing sporadically during treatment. The aim of this study is to investigate how systematic and random information appears in 2D transit dose distributions measured in the EPID plane over the entire course of a treatment and how this information can be used to examine interfractional trends, building toward a methodology to support adaptive radiotherapy. To create a trend overview of the interfractional changes in transit dose, the predicted portal dose for the different beams is compared to a measured portal dose using a γ evaluation. For each beam of the delivered fraction, information is extracted from the γ images to differentiate systematic from random dose delivery errors. From the systematic differences of a fraction for a projected anatomical structures, several metrics are extracted like percentage pixels with |γ| > 1. We demonstrate for four example cases the trends and dose difference causes which can be detected with this method. Two sample prostate cases show the occurrence of a random and systematic difference and identify the organ that causes the difference. In a lung cancer case a trend is shown of a rapidly diminishing atelectasis (lung fluid) during the course of treatment, which was detected with this trend analysis method. The final example is a breast cancer case where we show the influence of set-up differences on the 2D transit dose. A method is presented based on 2D portal transit dosimetry to record dose changes throughout the course of treatment, and to allow trend analysis of dose discrepancies. We show in example cases that this method can identify the causes of

  11. Volatility-dependent 2D IR correlation analysis of traditional Chinese medicine ‘Red Flower Oil’ preparation from different manufacturers

    NASA Astrophysics Data System (ADS)

    Wu, Yan-Wen; Sun, Su-Qin; Zhou, Qun; Tao, Jia-Xun; Noda, Isao

    2008-06-01

    As a traditional Chinese medicine (TCM), 'Red Flower Oil' preparation is widely used as a household remedy in China and Southeast Asia. Usually, the preparation is a mixture of several plant essential oils with different volatile features, such as wintergreen oil, turpentine oil and clove oil. The proportions of these plant essential oils in 'Red Flower Oil' vary from different manufacturers. Thus, it is important to develop a simple and rapid evaluation method for quality assurance of the preparations. Fourier transform infrared (FT-IR) was applied and two-dimensional correlation infrared spectroscopy (2D IR) based on the volatile characteristic of samples was used to enhance the resolution of FT-IR spectra. 2D IR technique could, not only easily provide the composition and their volatile sequences in 'Red flower Oil' preparations, but also rapidly discriminate the subtle differences in products from different manufacturers. Therefore, FT-IR combined with volatility-dependent 2D IR correlation analysis provides a very fast and effective method for the quality control of essential oil mixtures in TCM.

  12. von Neumann Stability Analysis of Numerical Solution Schemes for 1D and 2D Euler Equations

    NASA Astrophysics Data System (ADS)

    Konangi, Santosh; Palakurthi, Nikhil Kumar; Ghia, Urmila

    2014-11-01

    A von Neumann stability analysis is conducted for numerical schemes for the full system of coupled, density-based 1D and 2D Euler equations, closed by an isentropic equation of state. The governing equations are discretized on a staggered grid, which permits equivalence to finite-volume discretization. Presently, first-order accurate spatial and temporal finite-difference techniques are analyzed. The momentum convection term is treated as explicit, semi-implicit or implicit. Density upwind bias is included in the spatial operator of the continuity equation. By combining the discretization techniques, ten solution schemes are formulated. For each scheme, unstable and stable regimes are identified through the stability analysis, and the maximum allowable CFL number is predicted. The predictions are verified for selected schemes, using the Riemann problem at incompressible and compressible Mach numbers. Very good agreement is obtained between the analytically predicted and ``experimentally'' observed CFL values for all cases, thereby validating the analysis. The demonstrated analysis provides an accurate indication of stability conditions for the Euler equations, in contrast to the simplistic conditions arising from model equations, such as the wave equation.

  13. Analysis of the antiferromagnetic phase transitions of the 2D Kondo lattice

    NASA Astrophysics Data System (ADS)

    Jones, Barbara

    2010-03-01

    The Kondo lattice continues to present an interesting and relevant challenge, with its interactions between Kondo, RKKY, and coherent order. We present our study[1] of the antiferromagnetic quantum phase transitions of a 2D Kondo-Heisenberg square lattice. Starting from the nonlinear sigma model as a model of antiferromagnetism, we carry out a renormalization group analysis of the competing Kondo-RKKY interaction to one-loop order in an ɛ-expansion. We find a new quantum critical point (QCP) strongly affected by Kondo fluctuations. Near this QCP, there is a breakdown of hydrodynamic behavior, and the spin waves are logarithmically frozen out. The renormalization group results allow us to propose a new phase diagram near the antiferromagnetic fixed point of this 2D Kondo lattice model. The T=0 phase diagram contains four phases separated by a tetracritical point, the new QCP. For small spin fluctuations, we find a stable local magnetic moment antiferromagnet. For stronger coupling, region II is a metallic quantum disordered paramagnet. We find in region III a paramagnetic phase driven by Kondo interactions, with possible ground states of a heavy fermion liquid or a Kondo driven spin-liquid. The fourth phase is a spiral phase, or a large-Fermi-surface antiferromagnetic phase. We will describe these phases in more detail, including possible experimental confirmation of the spiral phase. The existence of the tetracritical point found here would be expected to affect the phase diagram at finite temperatures as well. In addition, It is hoped that these results, and particularly the Kondo interaction paramagnetic phase, will serve to bridge to solutions starting from the opposite limit, of a Kondo effect leading to a heavy fermion ground state. Work in collaboration with T. Tzen Ong. [4pt] [1] T. Ong and B. A. Jones, Phys. Rev. Lett. 103, 066405 (2009).

  14. Analysis of a thioether lubricant by infrared Fourier microemission spectrophotometry

    NASA Technical Reports Server (NTRS)

    Jones, W. R., Jr.; Morales, W.; Lauer, J. L.

    1986-01-01

    An infrared Fourier microemission spectrophotometer is used to obtain spectra (wavenumber range, 630 to 1230 0.1 cm) from microgram quantities of thioether lubricant samples deposited on aluminum foil. Infrared bands in the spectra are reproducible and could be identified as originating from aromatic species (1,3-disubstituted benzenes). Spectra from all samples (neat and formulated, used and unused) are very similar. Additives (an acid and a phosphinate) present in low concentration (0.10 percent) in the formulated fluid are not detected. This instrument appears to be a viable tool in helping to identify lubricant components separated by liquid chromatography.

  15. 2D proteome analysis initiates new Insights on the Salmonella Typhimurium LuxS protein

    PubMed Central

    2009-01-01

    Background Quorum sensing is a term describing a bacterial communication system mediated by the production and recognition of small signaling molecules. The LuxS enzyme, catalyzing the synthesis of AI-2, is conserved in a wide diversity of bacteria. AI-2 has therefore been suggested as an interspecies quorum sensing signal. To investigate the role of endogenous AI-2 in protein expression of the Gram-negative pathogen Salmonella enterica serovar Typhimurium (S. Typhimurium), we performed a 2D-DIGE proteomics experiment comparing total protein extract of wildtype S. Typhimurium with that of a luxS mutant, unable to produce AI-2. Results Differential proteome analysis of wildtype S. Typhimurium versus a luxS mutant revealed relatively few changes beyond the known effect on phase 2 flagellin. However, two highly differentially expressed protein spots with similar molecular weight but differing isoelectric point, were identified as LuxS whereas the S. Typhimurium genome contains only one luxS gene. This observation was further explored and we show that the S. Typhimurium LuxS protein can undergo posttranslational modification at a catalytic cysteine residue. Additionally, by constructing LuxS-βla and LuxS-PhoA fusion proteins, we demonstrate that S. Typhimurium LuxS can substitute the cognate signal peptide sequences of β-lactamase and alkaline phosphatase for translocation across the cytoplasmic membrane in S. Typhimurium. This was further confirmed by fractionation of S. Typhimurium protein extracts, followed by Western blot analysis. Conclusion 2D-DIGE analysis of a luxS mutant vs. wildtype Salmonella Typhimurium did not reveal new insights into the role of AI-2/LuxS in Salmonella as only a small amount of proteins were differentially expressed. However, subsequent in depth analysis of the LuxS protein itself revealed two interesting features: posttranslational modification and potential translocation across the cytoplasmic membrane. As the S. Typhimurium Lux

  16. Fourier analysis of a gated blood-pool study during atrial flutter

    SciTech Connect

    Makler, P.T. Jr.; McCarthy, D.M.; London, J.W.; Sandler, M.S.; Alavi, A.

    1983-08-01

    First-harmonic Fourier analysis of a gated blood-pool study is based on the assumption that the cardiac chambers contract once per cardiac cycle. In atrial arrhythmias this condition may not exist for the atria. We recently studied a patient with atrial flutter and 2:1 artioventricular conduction. There were predictable alterations in the first-harmonic Fourier phase and amplitude images. The observed changes from first-harmonic Fourier analysis were: (a) very low atrial amplitude values, and (b) absence of identifiable atrial regions on the phase image.

  17. A Fourier analysis for a fast simulation algorithm. [for switching converters

    NASA Technical Reports Server (NTRS)

    King, Roger J.

    1988-01-01

    This paper presents a derivation of compact expressions for the Fourier series analysis of the steady-state solution of a typical switching converter. The modeling procedure for the simulation and the steady-state solution is described, and some desirable traits for its matrix exponential subroutine are discussed. The Fourier analysis algorithm was tested on a phase-controlled parallel-loaded resonant converter, providing an experimental confirmation.

  18. 2D map projections for visualization and quantitative analysis of 3D fluorescence micrographs

    PubMed Central

    Sendra, G. Hernán; Hoerth, Christian H.; Wunder, Christian; Lorenz, Holger

    2015-01-01

    We introduce Map3-2D, a freely available software to accurately project up to five-dimensional (5D) fluorescence microscopy image data onto full-content 2D maps. Similar to the Earth’s projection onto cartographic maps, Map3-2D unfolds surface information from a stack of images onto a single, structurally connected map. We demonstrate its applicability for visualization and quantitative analyses of spherical and uneven surfaces in fixed and dynamic live samples by using mammalian and yeast cells, and giant unilamellar vesicles. Map3-2D software is available at http://www.zmbh.uni-heidelberg.de//Central_Services/Imaging_Facility/Map3-2D.html. PMID:26208256

  19. A 2D optomechanical focused laser spot scanner: analysis and experimental results for microstereolithography

    NASA Astrophysics Data System (ADS)

    Gandhi, P. S.; Deshmukh, S.

    2010-01-01

    This paper proposes and analyzes a 2D optomechanical-focused laser spot scanning system (patent pending) which allows uniform intensity focused spot scanning with high speed and high resolution over a large range of scan. Such scanning is useful where variation of focused spot characteristics affects the performance of applications such as micro-/nano-stereolithography, laser micro-machining, scanning optical tweezers, optical scanning microscopy, and so on. Proposed scanning is achieved by using linear movement of mirrors and lens maintaining the alignment of motion and optical axis of laser. Higher speed and high resolution at the same time are achieved by use of two serial double parallelogram flexural mechanisms with mechatronics developed around them. Optical analysis is carried out to demonstrate effectiveness of the proposed system numerically and is further supported by the experimental results. Additional analysis is carried out to demonstrate robustness of the scanner in the case of small misalignment errors incurred in actual practice. Although the proposed scanner is useful in general in several applications mentioned above, discussion in this paper is focused on microstereolithography.

  20. Guided-mode analysis by the Lanczos-Fourier expansion

    NASA Astrophysics Data System (ADS)

    Koukoutsaki, Panagiota A.; Tigelis, Ioannis G.; Manenkov, Alexander B.

    2002-11-01

    The Lanczos-Fourier series expansion is employed to analyze the guided-mode field in an asymmetrical slab waveguide, the core of which has an anisotropic and inhomogeneous dielectric permittivity. A system of linear homogeneous equations is derived by the collocation technique with consideration of the wave equation and the appropriate boundary conditions at the interfaces between the core and cladding media. The propagation constants are found from a determinant equation that ensures the existence of a nontrivial solution of the system. Numerical results are presented for several cases of dielectric permittivity, including the constant, parabolic, linear, and anisotropic cases. This approach is found to converge reasonably fast, and Richardson's extrapolation technique is applied to accelerate the convergence further. The approach can be easily generalized from the scalar to the vector equation, and, as an example, we consider the guided modes of a circular fiber.

  1. A comparative analysis of 2D and 3D CAD for calcifications in digital breast tomosynthesis

    NASA Astrophysics Data System (ADS)

    Acciavatti, Raymond J.; Ray, Shonket; Keller, Brad M.; Maidment, Andrew D. A.; Conant, Emily F.

    2015-03-01

    Many medical centers offer digital breast tomosynthesis (DBT) and 2D digital mammography acquired under the same compression (i.e., "Combo" examination) for screening. This paper compares a conventional 2D CAD algorithm (Hologic® ImageChecker® CAD v9.4) for calcification detection against a prototype 3D algorithm (Hologic® ImageChecker® 3D Calc CAD v1.0). Due to the newness of DBT, the development of this 3D CAD algorithm is ongoing, and it is currently not FDA-approved in the United States. For this study, DBT screening cases with suspicious calcifications were identified retrospectively at the University of Pennsylvania. An expert radiologist (E.F.C.) reviewed images with both 2D and DBT CAD marks, and compared the marks to biopsy results. Control cases with one-year negative follow-up were also studied; these cases either possess clearly benign calcifications or lacked calcifications. To allow the user to alter the sensitivity for cancer detection, an operating point is assigned to each CAD mark. As expected from conventional 2D CAD, increasing the operating point in 3D CAD increases sensitivity and reduces specificity. Additionally, we showed that some cancers are occult to 2D CAD at all operating points. By contrast, 3D CAD allows for detection of some cancers that are missed on 2D CAD. We also demonstrated that some non-cancerous CAD marks in 3D are not present at analogous locations in the 2D image. Hence, there are additional marks when using both 2D and 3D CAD in combination, leading to lower specificity than with conventional 2D CAD alone.

  2. Performance Analysis of the Microsoft Kinect Sensor for 2D Simultaneous Localization and Mapping (SLAM) Techniques

    PubMed Central

    Kamarudin, Kamarulzaman; Mamduh, Syed Muhammad; Shakaff, Ali Yeon Md; Zakaria, Ammar

    2014-01-01

    This paper presents a performance analysis of two open-source, laser scanner-based Simultaneous Localization and Mapping (SLAM) techniques (i.e., Gmapping and Hector SLAM) using a Microsoft Kinect to replace the laser sensor. Furthermore, the paper proposes a new system integration approach whereby a Linux virtual machine is used to run the open source SLAM algorithms. The experiments were conducted in two different environments; a small room with no features and a typical office corridor with desks and chairs. Using the data logged from real-time experiments, each SLAM technique was simulated and tested with different parameter settings. The results show that the system is able to achieve real time SLAM operation. The system implementation offers a simple and reliable way to compare the performance of Windows-based SLAM algorithm with the algorithms typically implemented in a Robot Operating System (ROS). The results also indicate that certain modifications to the default laser scanner-based parameters are able to improve the map accuracy. However, the limited field of view and range of Kinect's depth sensor often causes the map to be inaccurate, especially in featureless areas, therefore the Kinect sensor is not a direct replacement for a laser scanner, but rather offers a feasible alternative for 2D SLAM tasks. PMID:25490595

  3. Performance analysis of the Microsoft Kinect sensor for 2D Simultaneous Localization and Mapping (SLAM) techniques.

    PubMed

    Kamarudin, Kamarulzaman; Mamduh, Syed Muhammad; Shakaff, Ali Yeon Md; Zakaria, Ammar

    2014-01-01

    This paper presents a performance analysis of two open-source, laser scanner-based Simultaneous Localization and Mapping (SLAM) techniques (i.e., Gmapping and Hector SLAM) using a Microsoft Kinect to replace the laser sensor. Furthermore, the paper proposes a new system integration approach whereby a Linux virtual machine is used to run the open source SLAM algorithms. The experiments were conducted in two different environments; a small room with no features and a typical office corridor with desks and chairs. Using the data logged from real-time experiments, each SLAM technique was simulated and tested with different parameter settings. The results show that the system is able to achieve real time SLAM operation. The system implementation offers a simple and reliable way to compare the performance of Windows-based SLAM algorithm with the algorithms typically implemented in a Robot Operating System (ROS). The results also indicate that certain modifications to the default laser scanner-based parameters are able to improve the map accuracy. However, the limited field of view and range of Kinect's depth sensor often causes the map to be inaccurate, especially in featureless areas, therefore the Kinect sensor is not a direct replacement for a laser scanner, but rather offers a feasible alternative for 2D SLAM tasks. PMID:25490595

  4. Analysis of capacitive sensing for 2D-MEMS scanner laser projection

    NASA Astrophysics Data System (ADS)

    von Wantoch, Thomas; Mallas, Christian; Hofmann, Ulrich; Janes, Joachim; Wagner, Bernhard; Benecke, Wolfgang

    2014-03-01

    Typical applications for resonantly driven vacuum packaged MEMS scanners including laser projection displays require a feedback signal for closed-loop operation as well as high accuracy angle synchronization for data processing. A well known and widely used method is based on determining the angular velocity of the oscillating micromirror by measuring the time derivative of a capacitance. In this work we analyze a capacitive sensing approach that uses integrated vertical comb structures to synchronize the angular motion of a torsional micromirror oscillating in resonance. The investigated measurement method is implemented in a laser display that generates a video projection by scanning a RBG laser beam. As the 2D-micromirror performs sinusoidal oscillations on both perpendicular axes a continuously moving Lissajous pattern is projected. By measuring the displacement current due to an angular deflection of the movable comb structures an appropriate feedback signal for actuation and data synchronization is computed. In order to estimate the angular deflection and velocity a mathematical model of the capacitive sensing system is presented. In particular, the nonlinear characteristic of the capacitance as a function of the angle that is calculated using FEM analysis is approximated using cubic splines. Combining this nonlinear function with a dynamic model of the micromirror oscillation and the analog electronics a mathematical model of the capacitive measurement system is derived. To evaluate the proposed model numerical simulations are realized using MATLAB/Simulink and are compared to experimental measurements.

  5. Analysis of unsectioned specimens: 2D and tomographic PIXE with STIM

    NASA Astrophysics Data System (ADS)

    Schofield, Robert M. S.; Lefevre, Harlan W.

    1993-05-01

    Two techniques for quantitative analysis of heterogeneous thick specimens are reviewed. First, a measurement of the total zinc content in the abdomen of a fly is reported. The calculation used to determine the uncertainty in this measurement is detailed. STIM measurements at two different angles were used to determine the possible range of the X-ray production cross section and the X-ray attenuation factors. The abdomen content of zinc was determined to be 0.022( + 0.009, -0.006) (μg. Second, a PIXE-STIM mutomographic determination of metal concentrations in the sting of a scorpion is reviewed. STIM tomography was used to determine the X-ray production cross sections and the X-ray attenuation factors for points inside of the specimen. Details of how this information was then used for reconstructions of PIXE tomographic data are given. Finally, 2D PIXE measurements on a thick section of this sting are reported. On this section the measured concentration of zinc reached 22(± 3)% of dry mass, in satisfactory agreement with the results from tomography, 25(± 3)%.

  6. 2D-HPLC and MALDI-TOF/TOF analysis of barley proteins glycated during brewing.

    PubMed

    Petry-Podgórska, Inga; Zídková, Jitka; Flodrová, Dana; Bobálová, Janette

    2010-11-15

    The barley proteins have been the subject of interests of many research groups dealing with barley grains, malt and beer. The proteins which remain intact after harsh malting conditions influence the quality and flavor of beer. The characteristic feature of the proteins present in malt and beer is their extensive modification with carbohydrates, mainly glucose that comes from the starch degradation during technological processes. The degree of the protein glycation has an effect on the quality of malt and beer and on the properties of the beer foam. A combination of two-dimensional high performance liquid chromatography (2D-HPLC) and matrix assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF/TOF MS) was used for the analysis of the protein extracts that were reduced, alkylated, and degraded enzymatically without prior protein separation. This so-called "shot-gun" approach enabled us to determine glycation sites in one third of the proteins identified in the study and to propose potential glycation markers for fast and efficient monitoring during malting. PMID:20956095

  7. Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology.

    PubMed

    Smith, Benjamin R; Ashton, Katherine M; Brodbelt, Andrew; Dawson, Timothy; Jenkinson, Michael D; Hunt, Neil T; Palmer, David S; Baker, Matthew J

    2016-06-01

    Fourier transform infrared (FTIR) spectroscopy has long been established as an analytical technique for the measurement of vibrational modes of molecular systems. More recently, FTIR has been used for the analysis of biofluids with the aim of becoming a tool to aid diagnosis. For the clinician, this represents a convenient, fast, non-subjective option for the study of biofluids and the diagnosis of disease states. The patient also benefits from this method, as the procedure for the collection of serum is much less invasive and stressful than traditional biopsy. This is especially true of patients in whom brain cancer is suspected. A brain biopsy is very unpleasant for the patient, potentially dangerous and can occasionally be inconclusive. We therefore present a method for the diagnosis of brain cancer from serum samples using FTIR and machine learning techniques. The scope of the study involved 433 patients from whom were collected 9 spectra each in the range 600-4000 cm(-1). To begin the development of the novel method, various pre-processing steps were investigated and ranked in terms of final accuracy of the diagnosis. Random forest machine learning was utilised as a classifier to separate patients into cancer or non-cancer categories based upon the intensities of wavenumbers present in their spectra. Generalised 2D correlational analysis was then employed to further augment the machine learning, and also to establish spectral features important for the distinction between cancer and non-cancer serum samples. Using these methods, sensitivities of up to 92.8% and specificities of up to 91.5% were possible. Furthermore, ratiometrics were also investigated in order to establish any correlations present in the dataset. We show a rapid, computationally light, accurate, statistically robust methodology for the identification of spectral features present in differing disease states. With current advances in IR technology, such as the development of rapid discrete

  8. Gasoline analysis and brand identification using a static Fourier-transform ultraviolet spectrometer

    NASA Astrophysics Data System (ADS)

    Steers, Darren; Gerrard, Carl; Hirst, Bill; Sibbett, Wilson; Padgett, Miles J.

    1999-11-01

    The ultraviolet (UV) absorption spectra of several gasoline samples are measured using a compact static Fourier-transform (FT) spectrometer. The FT-UV spectrometer is constructed from crystalline quartz Wollaston prisms and polarizers fabricated from beta barium borate to form an interferogram in the spatial domain. The interferogram is recorded with a UV-sensitive detector array and Fourier transformed to yield spectra. Investigation using principal component analysis enables the identification of important gasoline properties such as origin.

  9. Fracture mode analysis and related surface deformation during dyke intrusion: Results from 2D experimental modelling

    NASA Astrophysics Data System (ADS)

    Abdelmalak, M.; Mourgues, R.; Bureau, D.

    2012-04-01

    The analysis of surface deformation in response to approaching intrusion is important for assessing volcanic hazards. In this paper, we present results from 2D scaled models of magma intrusion, in which we discuss the propagation mode and related surface deformation during dyke growth. Our experiments consist in the injection of analogue magma (Golden syrup) into cohesive fine-grained silica powder, simulating the brittle upper crust. Using an optical image correlation technique (Particle Imaging Velocimetry), we were able to follow the surface deformation, the displacements within the country rock and to calculate strains induced by the magma emplacement. We identified two kinds of intrusion morphologies resulting from different interactions between the dyke and plastic deformations occurring in the country rock near the surface. In both morphologies, the dyke is vertical at depth. Our analysis demonstrates that both hydraulic tensile opening and shear-related propagation operate during this first stage of vertical growth. At the same time, the surface lifted up and formed a smooth symmetrical dome. Both types of morphologies differ in the upper part. During a second stage of evolution, the first type of intrusion inclined at a dip between 45 to 65°. This inclination is not caused by shear deformations and is attributed to stress rotation near the tip. Closer to the surface, the growth of the inclined sheet creates shear bands which conduct the fluid toward the surface. The surface uplift becomes asymmetric. The second type of intrusion does not rotate at depth and continues its vertical propagation by catching vertical tensile cracks. The intrusion of magma in these cracks creates horizontal stresses which are responsible for the closure of fractures and the formation of reverse faults. At the surface the dome remains symmetrical. For both intrusions, the surface uplift accelerates during the second stage and it is strongly influenced by the presence or the

  10. Fourier optics analysis of grating sensors with tilt errors.

    PubMed

    Ferhanoglu, Onur; Toy, M Fatih; Urey, Hakan

    2011-06-15

    Dynamic diffraction gratings can be microfabricated with precision and offer extremely sensitive displacement measurements and light intensity modulation. The effect of pure translation of the moving part of the grating on diffracted order intensities is well known. This study focuses on the parameters that limit the intensity and the contrast of the interference. The effects of grating duty cycle, mirror reflectivities, sensor tilt and detector size are investigated using Fourier optics theory and Gaussian beam optics. Analytical findings reveal that fringe visibility becomes <0.3 when the optical path variation exceeds half the wavelength within the grating interferometer. The fringe visibility can be compensated by monitoring the interfering portion of the diffracted order light only through detector size reduction in the expense of optical power. Experiments were conducted with a grating interferometer that resulted in an eightfold increase in fringe visibility with reduced detector size, which is in agreement with theory. Findings show that diffraction grating readout principle is not limited to translating sensors but also can be used for sensors with tilt or other deflection modes. PMID:21685984

  11. Fourier transform infrared spectroscopic analysis of cell differentiation

    NASA Astrophysics Data System (ADS)

    Ishii, Katsunori; Kimura, Akinori; Kushibiki, Toshihiro; Awazu, Kunio

    2007-02-01

    Stem cells and its differentiations have got a lot of attentions in regenerative medicine. The process of differentiations, the formation of tissues, has become better understood by the study using a lot of cell types progressively. These studies of cells and tissue dynamics at molecular levels are carried out through various approaches like histochemical methods, application of molecular biology and immunology. However, in case of using regenerative sources (cells, tissues and biomaterials etc.) clinically, they are measured and quality-controlled by non-invasive methods from the view point of safety. Recently, the use of Fourier Transform Infrared spectroscopy (FT-IR) has been used to monitor biochemical changes in cells, and has gained considerable importance. The objective of this study is to establish the infrared spectroscopy of cell differentiation as a quality control of cell sources for regenerative medicine. In the present study, as a basic study, we examined the adipose differentiation kinetics of preadipocyte (3T3-L1) and the osteoblast differentiation kinetics of bone marrow mesenchymal stem cells (Kusa-A1) to analyze the infrared absorption spectra. As a result, we achieved to analyze the adipose differentiation kinetics using the infrared absorption peak at 1739 cm-1 derived from ester bonds of triglyceride and osteoblast differentiation kinetics using the infrared absorption peak at 1030 cm-1 derived from phosphate groups of calcium phosphate.

  12. Population pharmacokinetic analysis of risperidone and 9-hydroxyrisperidone with genetic polymorphisms of CYP2D6 and ABCB1.

    PubMed

    Yoo, Hee-Doo; Cho, Hea-Young; Lee, Sang-No; Yoon, Hwa; Lee, Yong-Bok

    2012-08-01

    This study estimated the population pharmacokinetics of risperidone and its active metabolite, 9-hydroxyrisperidone, according to genetic polymorphisms in the metabolizing enzyme (CYP2D6) and transporter (ABCB1) genes in healthy subjects. Eighty healthy subjects who received a single oral dose of 2 mg risperidone participated in this study. However, eight subjects with rare genotype variants in CYP2D6 alleles were excluded from the final model built in this study. We conducted the population pharmacokinetic analysis of risperidone and 9-hydroxyrisperidone using a nonlinear mixed effects modeling (NONMEM) method and explored the possible influence of genetic polymorphisms in CYP2D6 alleles and ABCB1 (2677G>T/A and 3435C>T) on the population pharmacokinetics of risperidone and 9-hydroxyrisperidone. A two-compartment model with a first-order absorption and lag time fitted well to serum concentration-time curve for risperidone. 9-hydroxyrisperidone was well described by a one-compartment model as an extension of the parent drug (risperidone) model with first-order elimination and absorption partially from the depot. Significant covariates for risperidone clearance were genetic polymorphisms of CYP2D6*10, including CYP2D6*1/*10 (27.5 % decrease) and CYP2D6*10/*10 (63.8 % decrease). There was significant difference in the absorption rate constant (k ( a )) of risperidone among the CYP2D6*10 genotype groups. In addition, combined ABCB1 3435C>T and CYP2D6*10 genotypes had a significant (P < 0.01) effect on the fraction of metabolite absorbed from the depot. The population pharmacokinetic model of risperidone and 9-hydroxyrisperidone including the genetic polymorphisms of CYP2D6*10 and ABCB1 3435C>T as covariates was successfully constructed. The estimated contribution of genetic polymorphisms in CYP2D6*10 and ABCB1 3435C>T to population pharmacokinetics of risperidone and 9-hydroxyrisperidone suggests the interplay of CYP2D6 and ABCB1 on the pharmacokinetics of

  13. Fourier Transform Methods Applied To The Analysis Of Microphotometric Images Of Histologic Sections

    NASA Astrophysics Data System (ADS)

    Dytch, Harvey E.; Wied, George L.

    1989-06-01

    Implementation of one-dimensional Fourier transform techniques for the analysis of histologic sections is discussed, as is the motivation for their use. Features of the frequency domain representation derived by such a transform are shown to be related to several important diagnostic clues. The interpretation of the Fourier magnitude spectrum in histologically relevant terms is examined by means of Fourier transforms of idealized tissue simulations. Some of the perturbations of these ideal spectra produced by biologic reality are discussed. Three classic types of cervical epithelial tissue are modeled, and their representation as Fourier magnitude spectra interpreted in the light of the previous results: characteristic frequency domain signatures are obtained for each. It is concluded that these techniques may provide diagnostically important objective measures, and may be applied to otherwise intractable histologic specimens with crowded and overlapping nuclei.

  14. PFC2D Analysis of Frank Slide rockfall deposit (Turtle Mountain, Canada)

    NASA Astrophysics Data System (ADS)

    Pons, Maria Güell I.; Charrière, Marie; Pedrazzini, Andrea; Froese, Corey; Jaboyedoff, Michel

    2010-05-01

    The eastern slope of Turtle Mountain collapse (Frank Slide, Alberta, Canada) involved a total of 30 M m3 of material and caused 70 fatalities in 1903. At the moment Turtle Mountain is one of the most monitored rock-slope sites in the world and several studies and simulations have been published. Detailed field work on the structural characteristics of the deposit has been performed (block size and lithology distribution, geomorphologic map of the deposit…). As an alternative to traditional numerical analysis, such as finite element methods or discontinuum methods, we analyze Frank Slide by means of the distinct element numerical model PFC2D, which considers the rock mass as an assembly of circular particles which can be bonded together and interact with each other and with the boundaries by contact laws. Assuming an initial configuration (given failure surface) several tests are made; firstly the movement is simulated as a granular flow (with no bonding between particles), secondly rock clusters are defined to match detached blocks identified in the field and thirdly the bonds between particles are enabled in order to account for first failure processes and block fragmentation. In order to simulate fracture, heterogeneity is implemented on bond resistance properties by a statistical function. Mechanic properties such as stresses, velocities and energy are monitored during the propagation process. Color markers for each lithology enable to identify internal deformation in the rockslide during emplacement. Results permit to compare the run-out distance and deposit configuration with spatial patterns observed in field work and might give insight to the nature of Frank Slide propagation.

  15. Analysis of 2D hyperbolic metamaterial dispersion by elementary excitation coupling

    NASA Astrophysics Data System (ADS)

    Vaianella, Fabio; Maes, Bjorn

    2016-04-01

    Hyperbolic metamaterials are examined for many applications thanks to the large density of states and extreme confinement of light they provide. For classical hyperbolic metal/dielectric multilayer structures, it was demon- strated that the properties originate from a specific coupling of the surface plasmon polaritons between the metal/dielectric interfaces. We show a similar analysis for 2D hyperbolic arrays of square (or rectangular) silver nanorods in a TiO2 host. In this case the properties derive from a specific coupling of the plasmons carried by the corners of the nanorods. The dispersion can be seen as the coupling of single rods for a through-metal connection of the corners, as the coupling of structures made of four semi-infinite metallic blocks separated by dielectric for a through-dielectric connection, or as the coupling of two semi-infinite rods for a through-metal and through-dielectric situation. For arrays of small square nanorods the elementary structure that explains the dispersion of the array is the single rod, and for arrays of large square nanorods it is four metallic corners. The medium size square nanorod case is more complicated, because the elementary structure can be one of the three basic designs, depending on the frequency and symmetry of the modes. Finally, we show that for arrays of rectangular nanorods the dispersion is explained by coupling of the two coupled rod structure. This work opens the way for a better understanding of a wide class of metamaterials via their elementary excitations.

  16. 2D signature for detection and identification of drugs

    NASA Astrophysics Data System (ADS)

    Trofimov, Vyacheslav A.; Varentsova, Svetlana A.; Shen, Jingling; Zhang, Cunlin; Zhou, Qingli; Shi, Yulei

    2011-06-01

    The method of spectral dynamics analysis (SDA-method) is used for obtaining the2D THz signature of drugs. This signature is used for the detection and identification of drugs with similar Fourier spectra by transmitted THz signal. We discuss the efficiency of SDA method for the identification problem of pure methamphetamine (MA), methylenedioxyamphetamine (MDA), 3, 4-methylenedioxymethamphetamine (MDMA) and Ketamine.

  17. 2-D nonlinear IIR-filters for image processing - An exploratory analysis

    NASA Technical Reports Server (NTRS)

    Bauer, P. H.; Sartori, M.

    1991-01-01

    A new nonlinear IIR filter structure is introduced and its deterministic properties are analyzed. It is shown to be better suited for image processing applications than its linear shift-invariant counterpart. The new structure is obtained from causality inversion of a 2D quarterplane causal linear filter with respect to the two directions of propagation. It is demonstrated, that by using this design, a nonlinear 2D lowpass filter can be constructed, which is capable of effectively suppressing Gaussian or impulse noise without destroying important image information.

  18. The Accuracy of Webcams in 2D Motion Analysis: Sources of Error and Their Control

    ERIC Educational Resources Information Center

    Page, A.; Moreno, R.; Candelas, P.; Belmar, F.

    2008-01-01

    In this paper, we show the potential of webcams as precision measuring instruments in a physics laboratory. Various sources of error appearing in 2D coordinate measurements using low-cost commercial webcams are discussed, quantifying their impact on accuracy and precision, and simple procedures to control these sources of error are presented.…

  19. Analysis of Korean Students' International Mobility by 2-D Model: Driving Force Factor and Directional Factor

    ERIC Educational Resources Information Center

    Park, Elisa L.

    2009-01-01

    The purpose of this study is to understand the dynamics of Korean students' international mobility to study abroad by using the 2-D Model. The first D, "the driving force factor," explains how and what components of the dissatisfaction with domestic higher education perceived by Korean students drives students' outward mobility to seek foreign…

  20. Analysis of vegetation effect on waves using a vertical 2-D RANS model

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A vertical two-dimensional (2-D) model has been applied in the simulation of wave propagation through vegetated water bodies. The model is based on an existing model SOLA-VOF which solves the Reynolds-Averaged Navier-Stokes (RANS) equations with the finite difference method on a staggered rectangula...

  1. Teaching time-series analysis. I. Finite Fourier analysis of ocean waves

    NASA Astrophysics Data System (ADS)

    Whitford, Dennis J.; Vieira, Mario E. C.; Waters, Jennifer K.

    2001-04-01

    The introduction of students to methods of time-series analysis is a pedagogical challenge, since the availability of easily manipulated computer software presents an attractive alternative to an understanding of the computations, as well as their assumptions and limitations. A two-part pedagogical tutorial exercise is offered as a hands-on laboratory to complement classroom discussions or as a reference for students involved in independent research projects. The exercises are focused on the analysis of ocean waves, specifically wind-generated surface gravity waves. The exercises are cross-disciplinary in nature and can be extended to any other field dealing with random signal analysis. The first exercise introduces the manual arithmetic steps of a finite Fourier analysis of a wave record, develops a spectrum, and compares these results to the results obtained using a fast Fourier transform (FFT). The second part of the exercise, described in the subsequent article, takes a longer wave record and addresses the theoretical and observed wave probability distributions of wave heights and sea surface elevations. These results are then compared to a FFT, thus linking the two pedagogical laboratory exercise parts for a more complete understanding of both exercises.

  2. Refined Fourier-transform method of analysis of full two-dimensional digitized interferograms

    NASA Astrophysics Data System (ADS)

    Lovrić, Davorin; Vučić, Zlatko; Gladić, Jadranko; Demoli, Nazif; Mitrović, Slobodan; Milas, Mirko

    2003-03-01

    A refined Fourier-transform method of analysis of interference patterns is presented. The refinements include a method of automatic background subtraction and a way of treating the problem of heterodyning. The method proves particularly useful for analysis of long sequences of interferograms.

  3. Differential Analysis of 2D NMR Spectra: New Natural Products from a Pilot-Scale Fungal Extract Library

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Using a newly developed protocol for the differential analysis of arrays of 2D NMR spectra, we were able to rapidly identify two previously unreported indole alkaloids from a library of unfractionated fungal extracts. Differential analyses of NMR spectra thus constitute an effective tool for the non...

  4. Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases

    SciTech Connect

    Krishnan, Swathi; Trievel, Raymond C.

    2013-01-08

    We found that JMJD2 lysine demethylases (KDMs) participate in diverse genomic processes. Most JMJD2 homologs display dual selectivity toward H3K9me3 and H3K36me3, with the exception of JMJD2D, which is specific for H3K9me3. Here, we report the crystal structures of the JMJD2D•2-oxoglutarate•H3K9me3 ternary complex and JMJD2D apoenzyme. Utilizing structural alignments with JMJD2A, molecular docking, and kinetic analysis with an array of histone peptide substrates, we elucidate the specific signatures that permit efficient recognition of H3K9me3 by JMJD2A and JMJD2D, and the residues in JMJD2D that occlude H3K36me3 demethylation. Surprisingly, these results reveal that JMJD2A and JMJD2D exhibit subtle yet important differences in H3K9me3 recognition, despite the overall similarity in the substrate-binding conformation. Further, we show that H3T11 phosphorylation abrogates demethylation by JMJD2 KDMs. These studies reveal the molecular basis for JMJD2 site specificity and provide a framework for structure-based design of selective inhibitors of JMJD2 KDMs implicated in disease.

  5. Human 2-D PAGE databases for proteome analysis in health and disease: http://biobase.dk/cgi-bin/celis.

    PubMed

    Celis, J E; Gromov, P; Ostergaard, M; Madsen, P; Honoré, B; Dejgaard, K; Olsen, E; Vorum, H; Kristensen, D B; Gromova, I; Haunsø, A; Van Damme, J; Puype, M; Vandekerckhove, J; Rasmussen, H H

    1996-12-01

    Human 2-D PAGE Databases established at the Danish Centre for Human Genome Research are now available on the World Wide Web (http://biobase.dk/cgi-bin/celis). The databanks, which offer a comprehensive approach to the analysis of the human proteome both in health and disease, contain data on known and unknown proteins recorded in various IEF and NEPHGE 2-D PAGE reference maps (non-cultured keratinocytes, non-cultured transitional cell carcinomas, MRC-5 fibroblasts and urine). One can display names and information on specific protein spots by clicking on the image of the gel representing the 2-D gel map in which one is interested. In addition, the database can be searched by protein name, keywords or organelle or cellular component. The entry files contain links to other databases such as Medline, Swiss-Prot, PIR, PDB, CySPID, OMIM, Methabolic pathways, etc. The on-line information is updated regularly. PMID:8977092

  6. First experiences with 2D-mXRF analysis of gunshot residue on garment, tissue, and cartridge cases

    NASA Astrophysics Data System (ADS)

    Knijnenberg, Alwin; Stamouli, Amalia; Janssen, Martin

    2014-09-01

    The investigation of garment and human tissue originating from a victim of a shooting incident can provide crucial information for the reconstruction of such an incident. The use of 2D-mXRF for such investigations has several advantages over current methods as this new technique can be used to scan large areas, provides simultaneous information on multiple elements, can be applied under ambient conditions and is non-destructive. In this paper we report our experiences and challenges with the implementation of 2D-mXRF in GSR analysis. Currently we mainly focus on the use of 2D-mXRF as a tool for visualizing elemental distributions on various samples.

  7. Multifractal and Singularity Maps of soil surface moisture distribution derived from 2D image analysis.

    NASA Astrophysics Data System (ADS)

    Cumbrera, Ramiro; Millán, Humberto; Martín-Sotoca, Juan Jose; Pérez Soto, Luis; Sanchez, Maria Elena; Tarquis, Ana Maria

    2016-04-01

    methods for mapping geochemical anomalies caused by buried sources and for predicting undiscovered mineral deposits in covered areas. Journal of Geochemical Exploration, 122, 55-70. Cumbrera, R., Ana M. Tarquis, Gabriel Gascó, Humberto Millán (2012) Fractal scaling of apparent soil moisture estimated from vertical planes of Vertisol pit images. Journal of Hydrology (452-453), 205-212. Martin Sotoca; J.J. Antonio Saa-Requejo, Juan Grau and Ana M. Tarquis (2016). Segmentation of singularity maps in the context of soil porosity. Geophysical Research Abstracts, 18, EGU2016-11402. Millán, H., Cumbrera, R. and Ana M. Tarquis (2016) Multifractal and Levy-stable statistics of soil surface moisture distribution derived from 2D image analysis. Applied Mathematical Modelling, 40(3), 2384-2395.

  8. Advances in fast 2D camera data handling and analysis on NSTX

    SciTech Connect

    Davis, W. M.; Patel, R. I.; Boeglin, W. U.; Roquemore, A. L.; Maqueda, R. J.; Zweben, S. J.

    2010-07-01

    The use of fast 2D cameras on NSTX continues to grow. There are 6 cameras with the capability of taking up to 1–2 gigabytes (GBs) of data apiece during each plasma shot on the National Spherical Torus Experiment (NSTX). Efficient storage and retrieval of this data remains a challenge. Performance comparisons are presented for reading data stored in MDSplus, using both compressed data and segmented records, and direct access I/O with different read sizes. Encouragingly, fast 2D camera data provides considerable insight into plasma complexities, such as small-scale turbulence and particle transport. The last part of this paper is an example of more recent uses: dual cameras looking at the same region of the plasma from different angles, which can provide trajectories of incandescent particles in 3D. A laboratory simulation of the 3D trajectories is presented, as well as corresponding data from NSTX plasma where glowing dust particles can be followed.

  9. Resonant loop antenna design with a 2-D steady state analysis

    SciTech Connect

    Chen, G.I.; Ryan, P.M.; Hoffman, D.J.; Baity, F.W.; Swain, D.W.; Whealton, J.H.

    1987-01-01

    Evaluation of resonant loop antenna designs for ICRF heating of plasmas requires information concerning the electrical characteristics of the structure. Our 2-D steady state model described herein provides us with current strap inductance and capacitance, surface current distributions, and flux linkage to the plasma. These are used to determine the current and voltage requirements, ohmic dissipation, frequency limits and matching requirements, maximum electric fields, and plasma loading in order to compare antenna designs.

  10. NMR Analysis of Unknowns: An Introduction to 2D NMR Spectroscopy

    ERIC Educational Resources Information Center

    Alonso, David E.; Warren, Steven E.

    2005-01-01

    A study combined 1D (one-dimensional) and 2D (two-dimensional) NMR spectroscopy to solve structural organic problems of three unknowns, which include 2-, 3-, and 4-heptanone. Results showed [to the first power]H NMR and [to the thirteenth power]C NMR signal assignments for 2- and 3-heptanone were more challenging than for 4-heptanone owing to the…

  11. Assessment of the site of ventricular activation by Fourier analysis of gated blood-pool studies

    SciTech Connect

    Links, J.M.; Raichlen, J.S.; Wagner, H.N. Jr.; Reid, P.R.

    1985-01-01

    The authors studied the use of first-harmonic Fourier analysis of gated blood-pool images to assess the site of ventricular activation in a group of 12 patients undergoing electrophysiologic pacing studies. They acquired gated blood-pool studies during pacing at up to four sites at each of two different rates. A total of 50 studies were made. At a pacing rate of 100 beats/min, when the pacing electrode was the right-ventricular outflow tract, 7/8; at the anterolateral left-ventricular wall, 4/4. When the Fourier activation site was at the right-ventricular apex, 9/9 times the pacing electrode was there; at the right-ventricular outflow tract, 7/10; in the left ventricle, 4/4. Fourier analysis of gated blood-pool studies can help identify the site of ventricular activation but is not sufficiently accurate to fully replace endocardial mapping.

  12. The combined use of order tracking techniques for enhanced Fourier analysis of order components

    NASA Astrophysics Data System (ADS)

    Wang, K. S.; Heyns, P. S.

    2011-04-01

    Order tracking is one of the most important vibration analysis techniques for diagnosing faults in rotating machinery. It can be performed in many different ways, each of these with distinct advantages and disadvantages. However, in the end the analyst will often use Fourier analysis to transform the data from a time series to frequency or order spectra. It is therefore surprising that the study of the Fourier analysis of order-tracked systems seems to have been largely ignored in the literature. This paper considers the frequently used Vold-Kalman filter-based order tracking and computed order tracking techniques. The main pros and cons of each technique for Fourier analysis are discussed and the sequential use of Vold-Kalman filtering and computed order tracking is proposed as a novel idea to enhance the results of Fourier analysis for determining the order components. The advantages of the combined use of these order tracking techniques are demonstrated numerically on an SDOF rotor simulation model. Finally, the approach is also demonstrated on experimental data from a real rotating machine.

  13. Parametrics on 2D Navier-Stokes analysis of a Mach 2.68 bifurcated rectangular mixed-compression inlet

    NASA Technical Reports Server (NTRS)

    Mizukami, M.; Saunders, J. D.

    1995-01-01

    The supersonic diffuser of a Mach 2.68 bifurcated, rectangular, mixed-compression inlet was analyzed using a two-dimensional (2D) Navier-Stokes flow solver. Parametric studies were performed on turbulence models, computational grids and bleed models. The computer flowfield was substantially different from the original inviscid design, due to interactions of shocks, boundary layers, and bleed. Good agreement with experimental data was obtained in many aspects. Many of the discrepancies were thought to originate primarily from 3D effects. Therefore, a balance should be struck between expending resources on a high fidelity 2D simulation, and the inherent limitations of 2D analysis. The solutions were fairly insensitive to turbulence models, grids and bleed models. Overall, the k-e turbulence model, and the bleed models based on unchoked bleed hole discharge coefficients or uniform velocity are recommended. The 2D Navier-Stokes methods appear to be a useful tool for the design and analysis of supersonic inlets, by providing a higher fidelity simulation of the inlet flowfield than inviscid methods, in a reasonable turnaround time.

  14. Characterization of novel isobenzofuranones by DFT calculations and 2D NMR analysis.

    PubMed

    Teixeira, Milena G; Alvarenga, Elson S

    2016-08-01

    Phthalides are frequently found in naturally occurring substances and exhibit a broad spectrum of biological activities. In the search for compounds with insecticidal activity, phthalides have been used as versatile building blocks for the syntheses of novel potential agrochemicals. In our work, the Diels-Alder reaction between furan-2(5H)-one and cyclopentadiene was used successfully to obtain (3aR,4S,7R,7aS)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1(3H)-one and (3aS,4R,7S,7aR)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1(3H)-one (2) and (3aS,4S,7R,7aR)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1(3H)-one and (3aR,4R,7S,7aS)-3a,4,7,7a-tetrahydro-4,7-methanoisobenzofuran-1(3H)-one (3). The endo adduct (2) was brominated to afford (3aR,4R,5R,7R,7aS,8R)-5,8-dibromohexahydro-4,7-methanoisobenzofuran-1(3H)-one and (3aS,4S,5S,7S,7aR,8S)-5,8-dibromohexahydro-4,7-methanoisobenzofuran-1(3H)-one (4) and (3aS,4R,5R,6S,7S,7aR)-5,6-dibromohexahydro-4,7-methanoisobenzofuran-1(3H)-one and (3aR,4S,5S,6R,7R,7aS)-5,6-dibromohexahydro-4,7-methanoisobenzofuran-1(3H)-one (5). Following the initial analysis of the NMR spectra and the proposed two novel unforeseen products, we have decided to fully analyze the classical and non-classical assay structures with the aid of computational calculations. Computation to predict the (13) C and (1) H chemical shifts for mean absolute error analyses have been carried out by gauge-including atomic orbital method at M06-2X/6-31+G(d,p) and B3LYP/6-311+G(2d,p) levels of theory for all viable conformers. Characterization of the novel unforeseen compounds (4) and (5) were not possible by employing only the experimental NMR data; however, a more conclusive structural identification was performed by comparing the experimental and theoretical (1) H and (13) C chemical shifts by mean absolute error and DP4 probability analyses. Copyright © 2016 John Wiley & Sons, Ltd. PMID:26811211

  15. 2D dynamic studies combined with the surface curvature analysis to predict Arias Intensity amplification

    NASA Astrophysics Data System (ADS)

    Torgoev, Almaz; Havenith, Hans-Balder

    2016-01-01

    A 2D elasto-dynamic modelling of the pure topographic seismic response is performed for six models with a total length of around 23.0 km. These models are reconstructed from the real topographic settings of the landslide-prone slopes situated in the Mailuu-Suu River Valley, Southern Kyrgyzstan. The main studied parameter is the Arias Intensity (Ia, m/sec), which is applied in the GIS-based Newmark method to regionally map the seismically-induced landslide susceptibility. This method maps the Ia values via empirical attenuation laws and our studies investigate a potential to include topographic input into them. Numerical studies analyse several signals with varying shape and changing central frequency values. All tests demonstrate that the spectral amplification patterns directly affect the amplification of the Ia values. These results let to link the 2D distribution of the topographically amplified Ia values with the parameter called as smoothed curvature. The amplification values for the low-frequency signals are better correlated with the curvature smoothed over larger spatial extent, while those values for the high-frequency signals are more linked to the curvature with smaller smoothing extent. The best predictions are provided by the curvature smoothed over the extent calculated according to Geli's law. The sample equations predicting the Ia amplification based on the smoothed curvature are presented for the sinusoid-shape input signals. These laws cannot be directly implemented in the regional Newmark method, as 3D amplification of the Ia values addresses more problem complexities which are not studied here. Nevertheless, our 2D results prepare the theoretical framework which can potentially be applied to the 3D domain and, therefore, represent a robust basis for these future research targets.

  16. Initial global 2-D shielding analysis for the Advanced Neutron Source core and reflector

    SciTech Connect

    Bucholz, J.A.

    1995-08-01

    This document describes the initial global 2-D shielding analyses for the Advanced Neutron Source (ANS) reactor, the D{sub 2}O reflector, the reflector vessel, and the first 200 mm of light water beyond the reflector vessel. Flux files generated here will later serve as source terms in subsequent shielding analyses. In addition to reporting fluxes and other data at key points of interest, a major objective of this report was to document how these analyses were performed, the phenomena that were included, and checks that were made to verify that these phenomena were properly modeled. In these shielding analyses, the fixed neutron source distribution in the core was based on the `lifetime-averaged` spatial power distribution. Secondary gamma production cross sections in the fuel were modified so as to account intrinsically for delayed fission gammas in the fuel as well as prompt fission gammas. In and near the fuel, this increased the low-energy gamma fluxes by 50 to 250%, but out near the reflector vessel, these same fluxes changed by only a few percent. Sensitivity studies with respect to mesh size were performed, and a new 2-D mesh distribution developed after some problems were discovered with respect to the use of numerous elongated mesh cells in the reflector. All of the shielding analyses were performed sing the ANSL-V 39n/44g coupled library with 25 thermal neutron groups in order to obtain a rigorous representation of the thermal neutron spectrum throughout the reflector. Because of upscatter in the heavy water, convergence was very slow. Ultimately, the fission cross section in the various materials had to be artificially modified in order to solve this fixed source problem as an eigenvalue problem and invoke the Vondy error-mode extrapolation technique which greatly accelerated convergence in the large 2-D RZ DORT analyses. While this was quite effective, 150 outer iterations (over energy) were still required.

  17. Microphysical Analysis using Airborne 2-D Cloud and Precipitation Imaging Probe Data

    NASA Astrophysics Data System (ADS)

    Guy, N.; Jorgensen, D.; Witte, M.; Chuang, P. Y.; Black, R. A.

    2013-12-01

    The NOAA P-3 instrumented aircraft provided in-situ cloud and precipitation microphysical observations during the DYNAMO (Dynamics of the Madden-Julian Oscillation) field experiment. The Particle Measuring System 2D cloud (2D-C) and precipitation (2D-P) probes collected data for particles between 12.5 μm - 1.55 mm (25 μm resolution) and 100 μm - 6.2 mm (100 μm resolution), respectively. Spectra from each instrument were combined to provide a broad distribution of precipitation particle sizes. The 'method of moments' technique was used to analyze drop size distribution (DSD) spectra, which were modeled by fitting a three-parameter (slope, shape, and intercept) gamma distribution to the spectra. The characteristic shape of the mean spectrum compares to previous maritime measurements. DSD variability will be presented with respect to the temporal evolution of cloud populations during a Madden-Julian Oscillation (MJO) event, as well as in-situ aircraft vertical wind velocity measurements. Using the third and sixth moments, rainfall rate (R) and equivalent radar reflectivity factor (Z), respectively, were computed for each DSD. Linear regression was applied to establish a Z-R relationship for the data for the estimation of precipitation. The study indicated unique characteristics of microphysical processes for this region. These results are important to continue to define the cloud population characteristics in the climatological MJO region. Improved representation of the cloud characteristics on the microphysical scale will serve as a check to model parameterizations, helping to improve numerical simulations.

  18. 2D dynamic studies combined with the surface curvature analysis to predict Arias Intensity amplification

    NASA Astrophysics Data System (ADS)

    Torgoev, Almaz; Havenith, Hans-Balder

    2016-07-01

    A 2D elasto-dynamic modelling of the pure topographic seismic response is performed for six models with a total length of around 23.0 km. These models are reconstructed from the real topographic settings of the landslide-prone slopes situated in the Mailuu-Suu River Valley, Southern Kyrgyzstan. The main studied parameter is the Arias Intensity (Ia, m/sec), which is applied in the GIS-based Newmark method to regionally map the seismically-induced landslide susceptibility. This method maps the Ia values via empirical attenuation laws and our studies investigate a potential to include topographic input into them. Numerical studies analyse several signals with varying shape and changing central frequency values. All tests demonstrate that the spectral amplification patterns directly affect the amplification of the Ia values. These results let to link the 2D distribution of the topographically amplified Ia values with the parameter called as smoothed curvature. The amplification values for the low-frequency signals are better correlated with the curvature smoothed over larger spatial extent, while those values for the high-frequency signals are more linked to the curvature with smaller smoothing extent. The best predictions are provided by the curvature smoothed over the extent calculated according to Geli's law. The sample equations predicting the Ia amplification based on the smoothed curvature are presented for the sinusoid-shape input signals. These laws cannot be directly implemented in the regional Newmark method, as 3D amplification of the Ia values addresses more problem complexities which are not studied here. Nevertheless, our 2D results prepare the theoretical framework which can potentially be applied to the 3D domain and, therefore, represent a robust basis for these future research targets.

  19. The use of Fourier functions to eliminate interferences in spectrophotometric analysis (theory and application).

    PubMed

    Wahbi, A M; Abdine, H; Korany, M A

    1978-05-01

    The basic principle for the use of Fourier functions in spectrophotometric analysis is discussed. Fourier function coefficients are linearly related to concentration and are associated with relative standard deviations of less than 1%. The proper choice of function and range, number of points and the transformation of an absorption curve are discussed. New trigonometric functions are derived to correct for linear irrelevant absorption. The method is illustrated by the determination of progesterone and testosterone propionate in oily solutions without prior chromatography. The results obtained are compared with those obtained using orthogonal polynomials. PMID:674337

  20. Analysis of 2D Phase Contrast MRI in Renal Arteries by Self Organizing Maps

    NASA Astrophysics Data System (ADS)

    Zöllner, Frank G.; Schad, Lothar R.

    We present an approach based on self organizing maps to segment renal arteries from 2D PC Cine MR, images to measure blood velocity and flow. Such information are important in grading renal artery stenosis and support the decision on surgical interventions like percu-tan transluminal angioplasty. Results show that the renal arteries could be extracted automatically. The corresponding velocity profiles show high correlation (r=0.99) compared those from manual delineated vessels. Furthermore, the method could detect possible blood flow patterns within the vessel.

  1. 2D-CELL: image processing software for extraction and analysis of 2-dimensional cellular structures

    NASA Astrophysics Data System (ADS)

    Righetti, F.; Telley, H.; Leibling, Th. M.; Mocellin, A.

    1992-01-01

    2D-CELL is a software package for the processing and analyzing of photographic images of cellular structures in a largely interactive way. Starting from a binary digitized image, the programs extract the line network (skeleton) of the structure and determine the graph representation that best models it. Provision is made for manually correcting defects such as incorrect node positions or dangling bonds. Then a suitable algorithm retrieves polygonal contours which define individual cells — local boundary curvatures are neglected for simplicity. Using elementary analytical geometry relations, a range of metric and topological parameters describing the population are then computed, organized into statistical distributions and graphically displayed.

  2. Numerical dispersion analysis for three-dimensional Laplace-Fourier-domain scalar wave equation

    NASA Astrophysics Data System (ADS)

    Chen, Jing-Bo

    2016-06-01

    Based on the phase velocity and attenuation propagation velocity, a method for performing numerical dispersion analysis of three-dimensional Laplace-Fourier-domain scalar wave equation is presented. This method is applied to a 27-point average-derivative optimal scheme and a 27-point finite-element scheme. Within the relative error of 1%, the 27-point average-derivative optimal scheme requires seven grid points per wavelength and pseudo-wavelength while the 27-point finite-element scheme requires 23 grid points per wavelength and pseudo-wavelength for equal and unequal directional sampling intervals. Numerical examples show that the 27-point Laplace-Fourier-domain average-derivative optimal scheme is more accurate than the 27-point Laplace-Fourier-domain finite-element scheme for the same computational cost. By using larger directional sampling intervals while maintaining accuracy, the 27-point Laplace-Fourier-domain average-derivative optimal scheme can greatly reduce the computational cost of three-dimensional Laplace-Fourier-domain modelling.

  3. Continuous Fourier transform method and apparatus. [for the analysis of simultaneous analog signal components

    NASA Technical Reports Server (NTRS)

    Munoz, R. M. (Inventor)

    1974-01-01

    An input analog signal to be frequency analyzed is separated into N number of simultaneous analog signal components each identical to the original but delayed relative to the original by a successively larger time delay. The separated and delayed analog components are combined together in a suitable number of adders and attenuators in accordance with at least one component product of the continuous Fourier transform and analog signal matrices to separate the analog input signal into at least one of its continuous analog frequency components of bandwidth 1/N times the bandwidth of the original input signal. The original analog input signal can be reconstituted by combining the separate analog frequency components in accordance with the component products of the continuous Fourier transform and analog frequency component matrices. The continuous Fourier transformation is useful for spectrum analysis, filtering, transfer function synthesis, and communications.

  4. Program for the analysis of time series. [by means of fast Fourier transform algorithm

    NASA Technical Reports Server (NTRS)

    Brown, T. J.; Brown, C. G.; Hardin, J. C.

    1974-01-01

    A digital computer program for the Fourier analysis of discrete time data is described. The program was designed to handle multiple channels of digitized data on general purpose computer systems. It is written, primarily, in a version of FORTRAN 2 currently in use on CDC 6000 series computers. Some small portions are written in CDC COMPASS, an assembler level code. However, functional descriptions of these portions are provided so that the program may be adapted for use on any facility possessing a FORTRAN compiler and random-access capability. Properly formatted digital data are windowed and analyzed by means of a fast Fourier transform algorithm to generate the following functions: (1) auto and/or cross power spectra, (2) autocorrelations and/or cross correlations, (3) Fourier coefficients, (4) coherence functions, (5) transfer functions, and (6) histograms.

  5. Performance analysis of SHE-PWM using Fourier Series and Newton-Raphson analysis

    NASA Astrophysics Data System (ADS)

    Lada, M. Y.; Khiar, M. S. A.; Ghani, S. A.; Nawawi, M. R. M.; Nor, A. S. M.; Yuen, J. G. M.

    2015-05-01

    The performance of inverter has become a vital role in contributing effective power system nowadays. However the major issue that will reduce the inverter performance is the harmonic distortions that contribute to power losses. Thus, there are a variety of controls techniques have been implemented for inverters switching such as square wave, SHE-PWM, unipolar and bipolar. The square wave type inverter produces output voltage in square shape which has simple logic control and power switches. Next, unipolar and bipolar techniques are using comparator to compare the reference voltage waveform with the triangular waveform. The difference between unipolar and bipolar is there are two reference signals which are compared with the triangular waveform for unipolar switching. On the other hand, bipolar switching compares triangular waveform with a reference signal. Selective Harmonic Elimination Pulse-Width Modulation (SHE-PWM) is another control technique for inverters. This research propose SHE-PWM as a low switching frequency strategy that uses Fourier Series and Newton-Raphson analysis to calculate the switching angles for elimination of harmonic distortion. Fourier Series is used to determine the amplitude of any odd harmonic in the output signal whereas Newton-Raphson is used to solve the equation for finding switching angles. As a result, SHE-PWM can select the low frequency harmonic components need to be eliminated and reduce the harmonic distortion. It also prevents the harmonic distortion that sensitive to the inverter performance

  6. Study on molecular structure and hydration mechanism of Domyoji-ko starch by IR and NIR hetero 2D analysis

    NASA Astrophysics Data System (ADS)

    Katayama, Norihisa; Kondo, Miyuki; Miyazawa, Mitsuhiro

    2010-06-01

    The hydration structure of starch molecule in Domyoji-ko, which is made from gluey rice, was investigated by hetero 2D correlation analysis of IR and NIR spectroscopy. The feature near 1020 cm -1 in the IR spectra of Domyoji-ko is changed by rehydration process, indicating that the molecular structure of amylopectin in the starch has been varied by the hydration without heating. The intensity of a band at 4770 cm -1 in NIR spectra is decreasing with the increasing of either the heating time with water or rehydration time without heating. These results suggest that the hydration of Domyoji-ko has proceeded in similar mechanisms on these processes. The generalized hetero 2D IR-NIR correlation analysis for rehydration of Domyoji-ko has supported the assignments for NIR bands concerning the gelatinization of starch.

  7. HEAT.PRO - THERMAL IMBALANCE FORCE SIMULATION AND ANALYSIS USING PDE2D

    NASA Technical Reports Server (NTRS)

    Vigue, Y.

    1994-01-01

    HEAT.PRO calculates the thermal imbalance force resulting from satellite surface heating. The heated body of a satellite re-radiates energy at a rate that is proportional to its temperature, losing the energy in the form of photons. By conservation of momentum, this momentum flux out of the body creates a reaction force against the radiation surface, and the net thermal force can be observed as a small perturbation that affects long term orbital behavior of the satellite. HEAT.PRO calculates this thermal imbalance force and then determines its effects on satellite orbits, especially where the Earth's shadowing of an orbiting satellite causes periodic changes in the spacecraft's thermal environment. HEAT.PRO implements a finite element method routine called PDE2D which incorporates material properties to determine the solar panel surface temperatures. The nodal temperatures are computed at specified time steps and are used to determine the magnitude and direction of the thermal force on the spacecraft. These calculations are based on the solar panel orientation and satellite's position with respect to the earth and sun. It is necessary to have accurate, current knowledge of surface emissivity, thermal conductivity, heat capacity, and material density. These parameters, which may change due to degradation of materials in the environment of space, influence the nodal temperatures that are computed and thus the thermal force calculations. HEAT.PRO was written in FORTRAN 77 for Cray series computers running UNICOS. The source code contains directives for and is used as input to the required partial differential equation solver, PDE2D. HEAT.PRO is available on a 9-track 1600 BPI magnetic tape in UNIX tar format (standard distribution medium) or a .25 inch streaming magnetic tape cartridge in UNIX tar format. An electronic copy of the documentation in Macintosh Microsoft Word format is included on the distribution tape. HEAT.PRO was developed in 1991. Cray and UNICOS are

  8. Analysis of collagen fiber domain organization by Fourier second harmonic generation microscopy

    NASA Astrophysics Data System (ADS)

    Ghazaryan, Ara; Tsai, Halley F.; Hayrapetyan, Gor; Chen, Wei-Liang; Chen, Yang-Fang; Jeong, Myung Yung; Kim, Chang-Seok; Chen, Shean-Jen; Dong, Chen-Yuan

    2013-03-01

    We present an automated and systematic two-dimensional discrete Fourier transform (2D-FFT) approach to analyze collagen fiber organization through the use of second harmonic generation (SHG) microscopy. Average orientations of individual domains and Ising-like order parameters introduced to characterize the correlation between orientations of adjacent domains may be used to quantitatively characterize fibrous tissues. Our approach was applied to analyze tissues including rat tail tendon, mouse skin, bovine corneas, and human corneas. We also show that collagen fiber organization in normal and keratokonus human corneas may be distinguished. The current approach may be used for the quantitative differentiation of SHG collagen fiber morphology in different tissues and may be applied for diagnostic purposes.

  9. Time sequence analysis of flickering auroras. I - Application of Fourier analysis. [in atmosphere

    NASA Technical Reports Server (NTRS)

    Berkey, F. T.; Silevitch, M. B.; Parsons, N. R.

    1980-01-01

    Using a technique that enables one to digitize the brightness of auroral displays from individual fields of a video signal, we have analyzed the frequency content of flickering aurora. Through the application of Fourier analysis to our data, we have found that flickering aurora contains a wide range of enhanced frequencies, although the dominant frequency enhancement generally occurs in the range 6-12 Hz. Each incidence of flickering that we observed was associated with increased radio wave absorption. Furthermore, we have found that flickering occurs in bright auroral surges, the occurrence of which is not limited to the 'breakup' phase of auroral substorms. Our results are interpreted in terms of a recently proposed theory of fluctuating double layers that accounts for a number of the observational features.

  10. Computational Study and Analysis of Structural Imperfections in 1D and 2D Photonic Crystals

    SciTech Connect

    K.R. Maskaly

    2005-06-01

    Dielectric reflectors that are periodic in one or two dimensions, also known as 1D and 2D photonic crystals, have been widely studied for many potential applications due to the presence of wavelength-tunable photonic bandgaps. However, the unique optical behavior of photonic crystals is based on theoretical models of perfect analogues. Little is known about the practical effects of dielectric imperfections on their technologically useful optical properties. In order to address this issue, a finite-difference time-domain (FDTD) code is employed to study the effect of three specific dielectric imperfections in 1D and 2D photonic crystals. The first imperfection investigated is dielectric interfacial roughness in quarter-wave tuned 1D photonic crystals at normal incidence. This study reveals that the reflectivity of some roughened photonic crystal configurations can change up to 50% at the center of the bandgap for RMS roughness values around 20% of the characteristic periodicity of the crystal. However, this reflectivity change can be mitigated by increasing the index contrast and/or the number of bilayers in the crystal. In order to explain these results, the homogenization approximation, which is usually applied to single rough surfaces, is applied to the quarter-wave stacks. The results of the homogenization approximation match the FDTD results extremely well, suggesting that the main role of the roughness features is to grade the refractive index profile of the interfaces in the photonic crystal rather than diffusely scatter the incoming light. This result also implies that the amount of incoherent reflection from the roughened quarterwave stacks is extremely small. This is confirmed through direct extraction of the amount of incoherent power from the FDTD calculations. Further FDTD studies are done on the entire normal incidence bandgap of roughened 1D photonic crystals. These results reveal a narrowing and red-shifting of the normal incidence bandgap with

  11. 2D correlation analysis of the magnetic excitations in Raman spectra of HoMnO3

    NASA Astrophysics Data System (ADS)

    Nguyen, Thi Huyen; Nguyen, Thi Minh Hien; Chen, Xiang-Bai; Yang, In-Sang; Park, Yeonju; Jung, Young Mee

    2014-07-01

    2D correlation analysis is performed on the temperature-dependent Raman spectra of HoMnO3 thin films. As the temperature of the HoMnO3 thin films decrease, the depletion of the spectral weight at 336, 656, and 1304 cm-1 occurs at higher temperatures than the increase of the intensity at 508, 766, and 945 cm-1 below ∼70 K, the Néel temperature. The power spectrum asserts that all the changes in the spectral weight are strongly correlated. Most of the temperature-induced spectral changes of HoMnO3 occur at lower temperature than 70 K, while there is slight depletion of the spectral weight at 336, 656, and 1304 cm-1 even at higher temperature than 70 K. PCA scores and loading vectors plots also support these 2D correlation results. Our 2D correlation analysis supports the existence of the short range spin correlations between Mn sites in HoMnO3 even above the Néel temperature.

  12. Novel Algorithm for Polar and Spherical Fourier Analysis on Two and Three Dimensional Images

    NASA Astrophysics Data System (ADS)

    Yang, Zhuo; Kamata, Sei-Ichiro

    Polar and Spherical Fourier analysis can be used to extract rotation invariant features for image retrieval and pattern recognition tasks. They are demonstrated to show superiorities comparing with other methods on describing rotation invariant features of two and three dimensional images. Based on mathematical properties of trigonometric functions and associated Legendre polynomials, fast algorithms are proposed for multimedia applications like real time systems and large multimedia databases in order to increase the computation speed. The symmetric points are computed simultaneously. Inspired by relative prime number theory, systematic analysis are given in this paper. Novel algorithm is deduced that provide even faster speed. Proposed method are 9-15% faster than previous work. The experimental results on two and three dimensional images are given to illustrate the effectiveness of the proposed method. Multimedia signal processing applications that need real time polar and spherical Fourier analysis can be benefit from this work.

  13. Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery.

    PubMed

    Stock, Kristin; Estrada, Marta F; Vidic, Suzana; Gjerde, Kjersti; Rudisch, Albin; Santo, Vítor E; Barbier, Michaël; Blom, Sami; Arundkar, Sharath C; Selvam, Irwin; Osswald, Annika; Stein, Yan; Gruenewald, Sylvia; Brito, Catarina; van Weerden, Wytske; Rotter, Varda; Boghaert, Erwin; Oren, Moshe; Sommergruber, Wolfgang; Chong, Yolanda; de Hoogt, Ronald; Graeser, Ralph

    2016-01-01

    Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been established and cross-comparisons made using three standard cell carcinoma lines: MCF7, LNCaP, NCI-H1437. Fluorescence-based growth curves, 3D image analysis, immunohistochemistry and treatment responses showed that end points differed according to cell type, stromal co-culture and culture format. The adaptable methodologies described here should guide the choice of appropriate simple and complex in vitro models. PMID:27364600

  14. Capturing tumor complexity in vitro: Comparative analysis of 2D and 3D tumor models for drug discovery

    PubMed Central

    Stock, Kristin; Estrada, Marta F.; Vidic, Suzana; Gjerde, Kjersti; Rudisch, Albin; Santo, Vítor E.; Barbier, Michaël; Blom, Sami; Arundkar, Sharath C.; Selvam, Irwin; Osswald, Annika; Stein, Yan; Gruenewald, Sylvia; Brito, Catarina; van Weerden, Wytske; Rotter, Varda; Boghaert, Erwin; Oren, Moshe; Sommergruber, Wolfgang; Chong, Yolanda; de Hoogt, Ronald; Graeser, Ralph

    2016-01-01

    Two-dimensional (2D) cell cultures growing on plastic do not recapitulate the three dimensional (3D) architecture and complexity of human tumors. More representative models are required for drug discovery and validation. Here, 2D culture and 3D mono- and stromal co-culture models of increasing complexity have been established and cross-comparisons made using three standard cell carcinoma lines: MCF7, LNCaP, NCI-H1437. Fluorescence-based growth curves, 3D image analysis, immunohistochemistry and treatment responses showed that end points differed according to cell type, stromal co-culture and culture format. The adaptable methodologies described here should guide the choice of appropriate simple and complex in vitro models. PMID:27364600

  15. Rifaximin-mediated changes to the epithelial cell proteome: 2-D gel analysis.

    PubMed

    Schrodt, Caroline; McHugh, Erin E; Gawinowicz, Mary Ann; Dupont, Herbert L; Brown, Eric L

    2013-01-01

    Rifaximin is a semi-synthetic rifamycin derivative that is used to treat different conditions including bacterial diarrhea and hepatic encephalopathy. Rifaximin is of particular interest because it is poorly adsorbed in the intestines and has minimal effect on colonic microflora. We previously demonstrated that rifaximin affected epithelial cell physiology by altering infectivity by enteric pathogens and baseline inflammation suggesting that rifaximin conferred cytoprotection against colonization and infection. Effects of rifaximin on epithelial cells were further examined by comparing the protein expression profile of cells pretreated with rifaximin, rifampin (control antibiotic), or media (untreated). Two-dimensional (2-D) gel electrophoresis identified 36 protein spots that were up- or down-regulated by over 1.7-fold in rifaximin treated cells compared to controls. 15 of these spots were down-regulated, including annexin A5, intestinal-type alkaline phosphatase, histone H4, and histone-binding protein RbbP4. 21 spots were up-regulated, including heat shock protein (HSP) 90α and fascin. Many of the identified proteins are associated with cell structure and cytoskeleton, transcription and translation, and cellular metabolism. These data suggested that in addition to its antimicrobial properties, rifaximin may alter host cell physiology that provides cytoprotective effects against bacterial pathogens. PMID:23922656

  16. Rifaximin-Mediated Changes to the Epithelial Cell Proteome: 2-D Gel Analysis

    PubMed Central

    Schrodt, Caroline; McHugh, Erin E.; Gawinowicz, Mary Ann; DuPont, Herbert L.; Brown, Eric L.

    2013-01-01

    Rifaximin is a semi-synthetic rifamycin derivative that is used to treat different conditions including bacterial diarrhea and hepatic encephalopathy. Rifaximin is of particular interest because it is poorly adsorbed in the intestines and has minimal effect on colonic microflora. We previously demonstrated that rifaximin affected epithelial cell physiology by altering infectivity by enteric pathogens and baseline inflammation suggesting that rifaximin conferred cytoprotection against colonization and infection. Effects of rifaximin on epithelial cells were further examined by comparing the protein expression profile of cells pretreated with rifaximin, rifampin (control antibiotic), or media (untreated). Two-dimensional (2-D) gel electrophoresis identified 36 protein spots that were up- or down-regulated by over 1.7-fold in rifaximin treated cells compared to controls. 15 of these spots were down-regulated, including annexin A5, intestinal-type alkaline phosphatase, histone H4, and histone-binding protein RbbP4. 21 spots were up-regulated, including heat shock protein (HSP) 90α and fascin. Many of the identified proteins are associated with cell structure and cytoskeleton, transcription and translation, and cellular metabolism. These data suggested that in addition to its antimicrobial properties, rifaximin may alter host cell physiology that provides cytoprotective effects against bacterial pathogens. PMID:23922656

  17. 2D CFD Analysis of an Airfoil with Active Continuous Trailing Edge Flap

    NASA Astrophysics Data System (ADS)

    Jaksich, Dylan; Shen, Jinwei

    2014-11-01

    Efficient and quieter helicopter rotors can be achieved through on-blade control devices, such as active Continuous Trailing-Edge Flaps driven by embedded piezoelectric material. This project aims to develop a CFD simulation tool to predict the aerodynamic characteristics of an airfoil with CTEF using open source code: OpenFOAM. Airfoil meshes used by OpenFOAM are obtained with MATLAB scripts. Once created it is possible to rotate the airfoil to various angles of attack. When the airfoil is properly set up various OpenFOAM properties, such as kinematic viscosity and flow velocity, are altered to achieve the desired testing conditions. Upon completion of a simulation, the program gives the lift, drag, and moment coefficients as well as the pressure and velocity around the airfoil. The simulation is then repeated across multiple angles of attack to give full lift and drag curves. The results are then compared to previous test data and other CFD predictions. This research will lead to further work involving quasi-steady 2D simulations incorporating NASTRAN to model aeroelastic deformation and eventually to 3D aeroelastic simulations. NSF ECE Grant #1358991 supported the first author as an REU student.

  18. Visual Analysis of time-dependent 2D Uncertainties in Decadal Climate Predictions

    NASA Astrophysics Data System (ADS)

    Böttinger, Michael; Röber, Niklas; Meier-Fleischer, Karin; Pohlmann, Holger

    2016-04-01

    Climate prediction systems used today for investigating the climate predictability on a decadal time scale are based on coupled global climate models. First, ensembles of hindcast experiments are carried out in order to derive the predictive skill of the prediction system. Then, in a second step, the prediction system is initialized with observations and actual future predictions are computed. The ensemble simulation techniques applied enable issuing of probabilistic information along with the quantities predicted. Different aspects of the uncertainty can be derived: The ensemble standard deviation (or ensemble spread) is a measure for the internal variability of the simulation, while the predictive skill is an inverse measure for the uncertainty in the prediction. In this work, we focus on the concurrent visualization of three related time-dependent 2D fields: the forecast variable itself, here the 2m temperature anomaly, along with the corresponding predictive skill and the ensemble spread which is given through the ensemble standard deviation. On the basis of temporally filtered data, animations are used to visualize the mean spatio-temporal development of the three quantities. Furthermore, seasonal analyses are similarly visualized in order to identify seasonal patterns. We show exemplary solutions produced with three different visualization systems: NCL, Avizo Green and ParaView. As example data set, we have used a decadal climate prediction carried out within the German research project "MiKlip - Decadal Predictions" using the MPI-M Earth System Model (MPI-ESM) from the Max Planck Institute for Meteorology in Hamburg.

  19. Accurate determination of the diffusion coefficient of proteins by Fourier analysis with whole column imaging detection.

    PubMed

    Zarabadi, Atefeh S; Pawliszyn, Janusz

    2015-02-17

    Analysis in the frequency domain is considered a powerful tool to elicit precise information from spectroscopic signals. In this study, the Fourier transformation technique is employed to determine the diffusion coefficient (D) of a number of proteins in the frequency domain. Analytical approaches are investigated for determination of D from both experimental and data treatment viewpoints. The diffusion process is modeled to calculate diffusion coefficients based on the Fourier transformation solution to Fick's law equation, and its results are compared to time domain results. The simulations characterize optimum spatial and temporal conditions and demonstrate the noise tolerance of the method. The proposed model is validated by its application for the electropherograms from the diffusion path of a set of proteins. Real-time dynamic scanning is conducted to monitor dispersion by employing whole column imaging detection technology in combination with capillary isoelectric focusing (CIEF) and the imaging plug flow (iPF) experiment. These experimental techniques provide different peak shapes, which are utilized to demonstrate the Fourier transformation ability in extracting diffusion coefficients out of irregular shape signals. Experimental results confirmed that the Fourier transformation procedure substantially enhanced the accuracy of the determined values compared to those obtained in the time domain. PMID:25607375

  20. Fourier-, Hilbert- and wavelet-based signal analysis: are they really different approaches?

    PubMed

    Bruns, Andreas

    2004-08-30

    Spectral signal analysis constitutes one of the most important and most commonly used analytical tools for the evaluation of neurophysiological signals. It is not only the spectral parameters per se (amplitude and phase) which are of interest, but there is also a variety of measures derived from them, including important coupling measures like coherence or phase synchrony. After reviewing some of these measures in order to underline the widespread relevance of spectral analysis, this report compares the three classical spectral analysis approaches: Fourier, Hilbert and wavelet transform. Recently, there seems to be increasing acceptance of the notion that Hilbert- or wavelet-based analyses be in some way superior to Fourier-based analyses. The present article counters such views by demonstrating that the three techniques are in fact formally (i.e. mathematically) equivalent when using the class of wavelets that is typically applied in spectral analyses. Moreover, spectral amplitude serves as an example to show that Fourier, Hilbert and wavelet analysis also yield equivalent results in practical applications to neuronal signals. PMID:15262077

  1. Establishing a direct connection between detrended fluctuation analysis and Fourier analysis

    NASA Astrophysics Data System (ADS)

    Kiyono, Ken

    2015-10-01

    To understand methodological features of the detrended fluctuation analysis (DFA) using a higher-order polynomial fitting, we establish the direct connection between DFA and Fourier analysis. Based on an exact calculation of the single-frequency response of the DFA, the following facts are shown analytically: (1) in the analysis of stochastic processes exhibiting a power-law scaling of the power spectral density (PSD), S (f ) ˜f-β , a higher-order detrending in the DFA has no adverse effect in the estimation of the DFA scaling exponent α , which satisfies the scaling relation α =(β +1 )/2 ; (2) the upper limit of the scaling exponents detectable by the DFA depends on the order of polynomial fit used in the DFA, and is bounded by m +1 , where m is the order of the polynomial fit; (3) the relation between the time scale in the DFA and the corresponding frequency in the PSD are distorted depending on both the order of the DFA and the frequency dependence of the PSD. We can improve the scale distortion by introducing the corrected time scale in the DFA corresponding to the inverse of the frequency scale in the PSD. In addition, our analytical approach makes it possible to characterize variants of the DFA using different types of detrending. As an application, properties of the detrending moving average algorithm are discussed.

  2. Simulation and analysis of solute transport in 2D fracture/pipe networks: The SOLFRAC program

    NASA Astrophysics Data System (ADS)

    Bodin, Jacques; Porel, Gilles; Delay, Fred; Ubertosi, Fabrice; Bernard, Stéphane; de Dreuzy, Jean-Raynald

    2007-01-01

    The Time Domain Random Walk (TDRW) method has been recently developed by Delay and Bodin [Delay, F. and Bodin, J., 2001. Time domain random walk method to simulate transport by advection-dispersion and matrix diffusion in fracture networks. Geophys. Res. Lett., 28(21): 4051-4054.] and Bodin et al. [Bodin, J., Porel, G. and Delay, F., 2003c. Simulation of solute transport in discrete fracture networks using the time domain random walk method. Earth Planet. Sci. Lett., 6566: 1-8.] for simulating solute transport in discrete fracture networks. It is assumed that the fracture network can reasonably be represented by a network of interconnected one-dimensional pipes (i.e. flow channels). Processes accounted for are: (1) advection and hydrodynamic dispersion in the channels, (2) matrix diffusion, (3) diffusion into stagnant zones within the fracture planes, (4) sorption reactions onto the fracture walls and in the matrix, (5) linear decay, and (6) mass sharing at fracture intersections. The TDRW method is handy and very efficient in terms of computation costs since it allows for the one-step calculation of the particle residence time in each bond of the network. This method has been programmed in C++, and efforts have been made to develop an efficient and user-friendly software, called SOLFRAC. This program is freely downloadable at the URL http://labo.univ-poitiers.fr/hydrasa/intranet/telechargement.htm. It calculates solute transport into 2D pipe networks, while considering different types of injections and different concepts of local dispersion within each flow channel. Post-simulation analyses are also available, such as the mean velocity or the macroscopic dispersion at the scale of the entire network. The program may be used to evaluate how a given transport mechanism influences the macroscopic transport behaviour of fracture networks. It may also be used, as is the case, e.g., with analytical solutions, to interpret laboratory or field tracer test experiments

  3. Analysis of the dose calculation accuracy for IMRT in lung: a 2D approach.

    PubMed

    Dvorak, Pavel; Stock, Markus; Kroupa, Bernhard; Bogner, Joachim; Georg, Dietmar

    2007-01-01

    The purpose of this study was to compare the dosimetric accuracy of IMRT plans for targets in lung with the accuracy of standard uniform-intensity conformal radiotherapy for different dose calculation algorithms. Tests were performed utilizing a special phantom manufactured from cork and polystyrene in order to quantify the uncertainty of two commercial TPS for IMRT in the lung. Ionization and film measurements were performed at various measuring points/planes. Additionally, single-beam and uniform-intensity multiple-beam tests were performed, in order to investigate deviations due to other characteristics of IMRT. Helax-TMS V6.1(A) was tested for 6, 10 and 25 MV and BrainSCAN 5.2 for 6 MV photon beams, respectively. Pencil beam (PB) with simple inhomogeneity correction and 'collapsed cone' (CC) algorithms were applied for dose calculations. However, the latter was not incorporated during optimization hence only post-optimization recalculation was tested. Two-dimensional dose distributions were evaluated applying the gamma index concept. Conformal plans showed the same accuracy as IMRT plans. Ionization chamber measurements detected deviations of up to 5% when a PB algorithm was used for IMRT dose calculations. Significant improvement (deviations approximately 2%) was observed when IMRT plans were recalculated with the CC algorithm, especially for the highest nominal energy. All gamma evaluations confirmed substantial improvement with the CC algorithm in 2D. While PB dose distributions showed most discrepancies in lower (<50%) and high (>90%) dose regions, the CC dose distributions deviated mainly in the high dose gradient (20-80%) region. The advantages of IMRT (conformity, intra-target dose control) should be counterbalanced with possible calculation inaccuracies for targets in the lung. Until no superior dose calculation algorithms are involved in the iterative optimization process it should be used with great care. When only PB algorithm with simple

  4. Patterns of ventricular emptying by Fourier analysis of gated blood-pool studies

    SciTech Connect

    Links, J.M.; Douglass, K.H.; Wagner, H.N. Jr.

    1980-10-01

    Temporal Fourier analysis was applied to the processing of ECG-gated cardiac blood-pool studies on a pixel-by-pixel basis, to yield information about the pattern of ventricular emptying in normal hearts and in others with conduction abnormalities. The transform data at the fundamental frequency (the heart rate) were used to construct two types of display: (a) a distribution histogram of the pixel phase values, and (b) a cinematic display of the wave of emptying as it spread over the cardiac chambers. Preliminary results indicate that temporal Fourier analysis permits visualization of the pattern of ventricular emptying, which may prove useful in the study of motion abnormalities and asynergies, including those resulting from myocardial hypertrophy or conduction abnormalities, and as an aid in the optimum placement of pacemakers.

  5. A fluctuation-induced plasma transport diagnostic based upon fast-Fourier transform spectral analysis

    NASA Technical Reports Server (NTRS)

    Powers, E. J.; Kim, Y. C.; Hong, J. Y.; Roth, J. R.; Krawczonek, W. M.

    1978-01-01

    A diagnostic, based on fast Fourier-transform spectral analysis techniques, that provides experimental insight into the relationship between the experimentally observable spectral characteristics of the fluctuations and the fluctuation-induced plasma transport is described. The model upon which the diagnostic technique is based and its experimental implementation is discussed. Some characteristic results obtained during the course of an experimental study of fluctuation-induced transport in the electric field dominated NASA Lewis bumpy torus plasma are presented.

  6. Turbulent Fluid Motion 5: Fourier Analysis, the Spectral Form of the Continuum Equations, and Homogeneous Turbulence

    NASA Technical Reports Server (NTRS)

    Deissler, Robert G.

    1996-01-01

    Background material on Fourier analysis and on the spectral form of the continuum equations, both averaged and unaveraged, are given. The equations are applied to a number of cases of homogeneous turbulence with and without mean gradients. Spectral transfer of turbulent activity between scales of motion is studied in some detail. The effects of mean shear, heat transfer, normal strain, and buoyancy are included in the analyses.

  7. Short time Fourier analysis of the electromyogram - Fast movements and constant contraction

    NASA Technical Reports Server (NTRS)

    Hannaford, Blake; Lehman, Steven

    1986-01-01

    Short-time Fourier analysis was applied to surface electromyograms (EMG) recorded during rapid movements, and during isometric contractions at constant forces. A portion of the data to be transformed by multiplying the signal by a Hamming window was selected, and then the discrete Fourier transform was computed. Shifting the window along the data record, a new spectrum was computed each 10 ms. The transformed data were displayed in spectograms or 'voiceprints'. This short-time technique made it possible to see time-dependencies in the EMG that are normally averaged in the Fourier analysis of these signals. Spectra of EMGs during isometric contractions at constant force vary in the short (10-20 ms) term. Short-time spectra from EMGs recorded during rapid movements were much less variable. The windowing technique picked out the typical 'three-burst pattern' in EMG's from both wrist and head movements. Spectra during the bursts were more consistent than those during isometric contractions. Furthermore, there was a consistent shift in spectral statistics in the course of the three bursts. Both the center frequency and the variance of the spectral energy distribution grew from the first burst to the second burst in the same muscle. The analogy between EMGs and speech signals is extended to argue for future applicability of short-time spectral analysis of EMG.

  8. Measuring sperm movement within the female reproductive tract using Fourier analysis.

    PubMed

    Nicovich, Philip R; Macartney, Erin L; Whan, Renee M; Crean, Angela J

    2015-02-01

    The adaptive significance of variation in sperm phenotype is still largely unknown, in part due to the difficulties of observing and measuring sperm movement in its natural, selective environment (i.e., within the female reproductive tract). Computer-assisted sperm analysis systems allow objective and accurate measurement of sperm velocity, but rely on being able to track individual sperm, and are therefore unable to measure sperm movement in species where sperm move in trains or bundles. Here we describe a newly developed computational method for measuring sperm movement using Fourier analysis to estimate sperm tail beat frequency. High-speed time-lapse videos of sperm movement within the female tract of the neriid fly Telostylinus angusticollis were recorded, and a map of beat frequencies generated by converting the periodic signal of an intensity versus time trace at each pixel to the frequency domain using the Fourier transform. We were able to detect small decreases in sperm tail beat frequency over time, indicating the method is sensitive enough to identify consistent differences in sperm movement. Fourier analysis can be applied to a wide range of species and contexts, and should therefore facilitate novel exploration of the causes and consequences of variation in sperm movement. PMID:25640702

  9. Mapping agroecological zones and time lag in vegetation growth by means of Fourier analysis of time series of NDVI images

    NASA Technical Reports Server (NTRS)

    Menenti, M.; Azzali, S.; Verhoef, W.; Van Swol, R.

    1993-01-01

    Examples are presented of applications of a fast Fourier transform algorithm to analyze time series of images of Normalized Difference Vegetation Index values. The results obtained for a case study on Zambia indicated that differences in vegetation development among map units of an existing agroclimatic map were not significant, while reliable differences were observed among the map units obtained using the Fourier analysis.

  10. Application of 2D-HPLC/taste dilution analysis on taste compounds in aniseed (Pimpinella anisum L.).

    PubMed

    Pickrahn, Stephen; Sebald, Karin; Hofmann, Thomas

    2014-09-24

    This is the first application of fully automated, preparative, two-dimensional HPLC combined with sensory analysis for taste compound discovery using a sweet and licorice-like bitter-tasting aniseed extract as an example. Compared to the traditional iterative fractionation of food extracts by sensory-guided sequential application of separation techniques, the fully automated 2D-HPLC allowed the comprehensive separation of the aniseed extract into 256 subfractions and reduced the fractionation time from about 1 week to <1day. Using a smart sensory strategy to locate high-impact fractions, e.g., by evaluating first-dimension fractions by reconstituting them from second-dimension subfractions, followed by straightforward application of the taste dilution analysis on the individual second-dimension subfractions revealed the sweet-tasting trans-anethole and the bitter-tasting trans-pseudoisoeugenol 2-methylbutyrate, showing recognition thresholds of 70 and 68 μmol/L, respectively, as the primary orosensory active compounds in aniseed. 2D-HPLC combined with smart sensory analysis seems to be a promising strategy to speed the discovery of the key players imparting the attractive taste of foods. PMID:25186288

  11. Analysis of a polarization-independent nonlinear cross-slot waveguide with Fourier Modal Method (FMM)

    NASA Astrophysics Data System (ADS)

    Paul, Somnath; Tervo, Jani; Honakanen, Seppo

    2014-05-01

    We propose the Fourier Modal Method (FMM) as a convenient numerical tool for the design and analysis of nonlinear optical waveguides. The scope of this work includes the design of a polarization-independent nonlinear cross-slot waveguide for telecommunication applications at the wavelength of 1550 nm. The FMM method has been implemented, obeying the proper Fourier factorization rules, within a MATLABTM environment. The influence of the modal field intensity on the transverse refractive index distribution due to the optical Kerr effect is modeled with FMM for a propagation invariant scheme of the waveguide. The waveguide is geometrically optimized for an enhanced nonlinear light matter interaction. A silicon-inorganic hybrid material platform based on hydrogenated amorphous silicon (a-Si:H) and amorphous titanium dioxide (TiO2) is considered for the mentioned waveguide. With the optimized design of the waveguide, the achieved value of the nonlinear waveguide parameter (γ) is 4.678 × 104 W-1Km-1.

  12. Analysis of moire fringes by Wiener filtering: An extension to the Fourier method

    SciTech Connect

    Harasse, Sebastien; Yashiro, Wataru; Momose, Atsushi

    2012-07-31

    In X-ray Talbot interferometry, tilting the phase grating with respect to the absorption grating results in the formation of spatial fringes. The analysis of this moire pattern, classically performed by the Fourier method, allows the extraction of the sample phase shift information from a single image. In this context, an extension to the Fourier method is proposed. The filter used to extract the fringe information is chosen optimally in the least-squares sense, given models for the zeroth and first order modes, noise and the modulation transfer function. The latter is obtained by measuring the detector response to moire fringes with increasing frequencies. The obtained Wiener filter allows a better reconstruction of the phase information at all fringe frequencies, compared to the usual box or gaussian filters. This is demonstrated quantitatively by experiments using synchrotron radiation.

  13. Analysis of moiré fringes by Wiener filtering: An extension to the Fourier method

    NASA Astrophysics Data System (ADS)

    Harasse, Sébastien; Yashiro, Wataru; Momose, Atsushi

    2012-07-01

    In X-ray Talbot interferometry, tilting the phase grating with respect to the absorption grating results in the formation of spatial fringes. The analysis of this moiré pattern, classically performed by the Fourier method, allows the extraction of the sample phase shift information from a single image. In this context, an extension to the Fourier method is proposed. The filter used to extract the fringe information is chosen optimally in the least-squares sense, given models for the zeroth and first order modes, noise and the modulation transfer function. The latter is obtained by measuring the detector response to moiré fringes with increasing frequencies. The obtained Wiener filter allows a better reconstruction of the phase information at all fringe frequencies, compared to the usual box or gaussian filters. This is demonstrated quantitatively by experiments using synchrotron radiation.

  14. An application of the Fourier Series in the analysis of waterhammer in pumped storage plant

    SciTech Connect

    Serpas, D.

    1995-12-31

    In a pumped storage scheme, water flows from the upper reservoir to the lower reservoir, and the turbo/machine acts as turbine. In the pumping mode, the water is pumped from the lower reservoir to the upper reservoir, and the turbo/machine acts as a pump. A method using Fourier Series for the approximation of the characteristics curves of the pump in four quadrants is applied for the analysis of waterhammer due the power failure. Others conditions may also be analyzed. A program adjusts the data of the four characteristic curves in CHAUDRHY, 1987 by Fourier Series. This adjustment should permit a closer representation of the pump actually used in the system that will result in a more economical design.

  15. [Identification and analysis of genuine and false Flos Rosae Rugosae by FTIR and 2D correlation IR spectroscopy].

    PubMed

    Cai, Fang; Sun, Su-qin; Yan, Wen-rong; Niu, Shi-jie; Li, Xian-en

    2009-09-01

    The genuine and false Flos Rosae Rugosae (Flos Rosae Chinensis and Flos Rosa multiflora) were examined in terms of their differences by using Fourier transform infrared spectroscopy (FTIR) combined with two-dimensional (2D) correlation IR spectroscopy. The three species were shown very similar in FTIR spectra. The peak of 1318 cm(-1) of genuine Flos Rosae Rugosae is not obvious but this peak could be found sharp in Flos Rosae Chinensis and Flos Rosa multiflora. Generally, the second derivative IR spectrum can clearly enhance the spectral resolution. Flos Rosae Rugosae and Flos rosae Chinensis have aromatic compounds distinct fingerprint characteristics at 1 617 and 1 618 cm(-1), respectively. Nevertheless, FlosRosa multiflora has the peak at 1612 cm(-1). There is a discrepancy of 5 to 6 cm(-1). FlosRosa multiflora has glucide's distinct fingerprint characteristics at 1 044 cm(-1), but Flos Rosae Rugosae and Flos Rosae Chinensis don't. The second derivative infrared spectra indicated different fingerprint characteristics. Three of them showed aromatic compounds with autopeaks at 1620, 1560 and 1460 cm(-1). Flos Rosae Chinensis and Flos Rosa multiflora have the shoulder peak at 1660 cm(-1). In the range of 850-1250 cm(-1), three of them are distinct different, Flos Rosae Rugosae has the strongest autopeak, Flos Rosae Chinensis has the feeble autopeak and Flos Rosa multiflora has no autopeak at 1050 cm(-1). In third-step identification, the different contents of aromatic compounds and glucide in Flos Rosae Rugosae, Flos Rosae Chinensis and Flos Rosa multiflora were revealed. It is proved that the method is fast and effective for distinguishing and analyzing genuine Flos Rosae Rugosae and false Flos Rosae Rugosae (Flos Rosae Chinensis and Flos Rosa multiflora). PMID:19950645

  16. Multichannel response analysis on 2D projection views for detection of clustered microcalcifications in digital breast tomosynthesis

    SciTech Connect

    Wei, Jun Chan, Heang-Ping; Hadjiiski, Lubomir M.; Helvie, Mark A.; Lu, Yao; Zhou, Chuan; Samala, Ravi

    2014-04-15

    Purpose: To investigate the feasibility of a new two-dimensional (2D) multichannel response (MCR) analysis approach for the detection of clustered microcalcifications (MCs) in digital breast tomosynthesis (DBT). Methods: With IRB approval and informed consent, a data set of two-view DBTs from 42 breasts containing biopsy-proven MC clusters was collected in this study. The authors developed a 2D approach for MC detection using projection view (PV) images rather than the reconstructed three-dimensional (3D) DBT volume. Signal-to-noise ratio (SNR) enhancement processing was first applied to each PV to enhance the potential MCs. The locations of MC candidates were then identified with iterative thresholding. The individual MCs were decomposed with Hermite–Gaussian (HG) and Laguerre–Gaussian (LG) basis functions and the channelized Hotelling model was trained to produce the MCRs for each MC on the 2D images. The MCRs from the PVs were fused in 3D by a coincidence counting method that backprojects the MC candidates on the PVs and traces the coincidence of their ray paths in 3D. The 3D MCR was used to differentiate the true MCs from false positives (FPs). Finally a dynamic clustering method was used to identify the potential MC clusters in the DBT volume based on the fact that true MCs of clinical significance appear in clusters. Using two-fold cross validation, the performance of the 3D MCR for classification of true and false MCs was estimated by the area under the receiver operating characteristic (ROC) curve and the overall performance of the MCR approach for detection of clustered MCs was assessed by free response receiver operating characteristic (FROC) analysis. Results: When the HG basis function was used for MCR analysis, the detection of MC cluster achieved case-based test sensitivities of 80% and 90% at the average FP rates of 0.65 and 1.55 FPs per DBT volume, respectively. With LG basis function, the average FP rates were 0.62 and 1.57 per DBT volume at

  17. A 2-D oscillating flow analysis in Stirling engine heat exchangers

    NASA Technical Reports Server (NTRS)

    Ahn, Kyung H.; Ibrahim, Mounir B.

    1991-01-01

    A two-dimensional oscillating flow analysis was conducted, simulating the gas flow inside Stirling heat exchangers. Both laminar and turbulent oscillating pipe flow were investigated numerically for Re(max) = 1920 (Va = 80), 10800 (Va = 272), 19300 (Va = 272), and 60800 (Va = 126). The results are compared with experimental results of previous investigators. Also, predictions of the flow regime on present oscillating flow conditions were checked by comparing velocity amplitudes and phase differences with those from laminar theory and quasi-steady profile. A high Reynolds number k-epsilon turbulence model was used for turbulent oscillating pipe flow. Finally, performance evaluation of the K-epsilon model was made to explore the applicability of quasi-steady turbulent models to unsteady oscillating flow analysis.

  18. A 2-D oscillating flow analysis in Stirling engine heat exchangers

    NASA Technical Reports Server (NTRS)

    Ahn, Kyung H.; Ibrahim, Mounir B.

    1991-01-01

    A two dimensional oscillating flow analysis was conducted, simulating the gas flow inside Stirling heat exchangers. Both laminar and turbulent oscillating pipe flow were investigated numerically for Re(max) = 1920 (Va = 80), 10800 (Va = 272), 19300 (Va = 272), and 60800 (Va = 126). The results are compared with experimental results of previous investigators. Also, predictions of the flow regime on present oscillating flow conditions were checked by comparing velocity amplitudes and phase differences with those from laminar theory and quasi-steady profile. A high Reynolds number k-epsilon turbulence model was used for turbulent oscillating pipe flow. Finally, performance evaluation of the K-epsilon model was made to explore the applicability of quasi-steady turbulent models to unsteady oscillating flow analysis.

  19. A wideband FMBEM for 2D acoustic design sensitivity analysis based on direct differentiation method

    NASA Astrophysics Data System (ADS)

    Chen, Leilei; Zheng, Changjun; Chen, Haibo

    2013-09-01

    This paper presents a wideband fast multipole boundary element method (FMBEM) for two dimensional acoustic design sensitivity analysis based on the direct differentiation method. The wideband fast multipole method (FMM) formed by combining the original FMM and the diagonal form FMM is used to accelerate the matrix-vector products in the boundary element analysis. The Burton-Miller formulation is used to overcome the fictitious frequency problem when using a single Helmholtz boundary integral equation for exterior boundary-value problems. The strongly singular and hypersingular integrals in the sensitivity equations can be evaluated explicitly and directly by using the piecewise constant discretization. The iterative solver GMRES is applied to accelerate the solution of the linear system of equations. A set of optimal parameters for the wideband FMBEM design sensitivity analysis are obtained by observing the performances of the wideband FMM algorithm in terms of computing time and memory usage. Numerical examples are presented to demonstrate the efficiency and validity of the proposed algorithm.

  20. Feasibility of radial and circumferential strain analysis using 2D speckle tracking echocardiography in cats.

    PubMed

    Takano, Hiroshi; Isogai, Tomomi; Aoki, Takuma; Wakao, Yoshito; Fujii, Yoko

    2015-02-01

    The purpose of the present study is to investigate the feasibility of strain analysis using speckle tracking echocardiography (STE) in cats and to evaluate STE variables in cats with hypertrophic cardiomyopathy (HCM). Sixteen clinically healthy cats and 17 cats with HCM were used. Radial and circumferential strain and strain rate variables in healthy cats were measured using STE to assess the feasibility. Comparisons of global strain and strain variables between healthy cats and cats with HCM were performed. Segmental assessments of left ventricle (LV) wall for strain and strain rate variables in cats with HCM were also performed. As a result, technically adequate images were obtained in 97.6% of the segments for STE analysis. Sedation using buprenorphine and acepromazine did not affect any global strain nor strain rate variable. In LV segments of cats with HCM, reduced segmental radial strain and strain rate variables had significantly related with segmental LV hypertrophy. It is concluded that STE analysis using short axis images of LV appeared to be clinically feasible in cats, having the possibility to be useful for detecting myocardial dysfunctions in cats with diseased heart. PMID:25373881

  1. Analysis of simple 2-D and 3-D metal structures subjected to fragment impact

    NASA Technical Reports Server (NTRS)

    Witmer, E. A.; Stagliano, T. R.; Spilker, R. L.; Rodal, J. J. A.

    1977-01-01

    Theoretical methods were developed for predicting the large-deflection elastic-plastic transient structural responses of metal containment or deflector (C/D) structures to cope with rotor burst fragment impact attack. For two-dimensional C/D structures both, finite element and finite difference analysis methods were employed to analyze structural response produced by either prescribed transient loads or fragment impact. For the latter category, two time-wise step-by-step analysis procedures were devised to predict the structural responses resulting from a succession of fragment impacts: the collision force method (CFM) which utilizes an approximate prediction of the force applied to the attacked structure during fragment impact, and the collision imparted velocity method (CIVM) in which the impact-induced velocity increment acquired by a region of the impacted structure near the impact point is computed. The merits and limitations of these approaches are discussed. For the analysis of 3-d responses of C/D structures, only the CIVM approach was investigated.

  2. Feasibility of radial and circumferential strain analysis using 2D speckle tracking echocardiography in cats

    PubMed Central

    TAKANO, Hiroshi; ISOGAI, Tomomi; AOKI, Takuma; WAKAO, Yoshito; FUJII, Yoko

    2014-01-01

    The purpose of the present study is to investigate the feasibility of strain analysis using speckle tracking echocardiography (STE) in cats and to evaluate STE variables in cats with hypertrophic cardiomyopathy (HCM). Sixteen clinically healthy cats and 17 cats with HCM were used. Radial and circumferential strain and strain rate variables in healthy cats were measured using STE to assess the feasibility. Comparisons of global strain and strain variables between healthy cats and cats with HCM were performed. Segmental assessments of left ventricle (LV) wall for strain and strain rate variables in cats with HCM were also performed. As a result, technically adequate images were obtained in 97.6% of the segments for STE analysis. Sedation using buprenorphine and acepromazine did not affect any global strain nor strain rate variable. In LV segments of cats with HCM, reduced segmental radial strain and strain rate variables had significantly related with segmental LV hypertrophy. It is concluded that STE analysis using short axis images of LV appeared to be clinically feasible in cats, having the possibility to be useful for detecting myocardial dysfunctions in cats with diseased heart. PMID:25373881

  3. Quantitative analysis of oils and fats by Fourier transform Raman spectroscopy

    NASA Astrophysics Data System (ADS)

    Sadeghi-Jorabchi, H.; Wilson, R. H.; Belton, P. S.; Edwards-Webb, J. D.; Coxon, D. T.

    The rapid analysis of fats and oils is of great importance in the food industry. It is shown that Fourier transform Raman spectroscopy may be used for this purpose. Good quality spectra, free of fluorescence, may be obtained and the spectra may be interpreted in terms of changes in total unsaturation, cis/trans isomer ratios and the number of double bonds in the hydrocarbon chains. Quantitative analysis of total unsaturation and cis/trans is possible and offers considerable improvements in speed when compared with conventional methods.

  4. Study of Longperiod Global Oscillations of Sun Through Spherical Harmonic Fourier Analysis of Sunspot Activity

    NASA Astrophysics Data System (ADS)

    Gokhale, M. H.

    A spherical harmonic Fourier analysis of the maximum areas of sunspot groups listed in Ledgers I and II of Greenwich photoheliographic results for 1933 - 1954 yield significant peaks at the 11 y periodicity for some spherical harmonic modes: especially the mode (l = 6, m = 0). A similar analysis of the daily areas of the spotgroups during 1944 - 1954 yields 11 y periodicity peaks only for some non-axisymmetric modes. These results suggest that the sunspot activity may be physically related to long period global oscillations of the sun.

  5. Coupled 2D-3D finite element method for analysis of a skin panel with a discontinuous stiffener

    NASA Technical Reports Server (NTRS)

    Wang, J. T.; Lotts, C. G.; Davis, D. D., Jr.; Krishnamurthy, T.

    1992-01-01

    This paper describes a computationally efficient analysis method which was used to predict detailed stress states in a typical composite compression panel with a discontinuous hat stiffener. A global-local approach was used. The global model incorporated both 2D shell and 3D brick elements connected by newly developed transition elements. Most of the panel was modeled with 2D elements, while 3D elements were employed to model the stiffener flange and the adjacent skin. Both linear and geometrically nonlinear analyses were performed on the global model. The effect of geometric nonlinearity induced by the eccentric load path due to the discontinuous hat stiffener was significant. The local model used a fine mesh of 3D brick elements to model the region at the end of the stiffener. Boundary conditions of the local 3D model were obtained by spline interpolation of the nodal displacements from the global analysis. Detailed in-plane and through-the-thickness stresses were calculated in the flange-skin interface near the end of the stiffener.

  6. Two dimensional correlation analysis of Fourier transform ion cyclotron resonance mass spectra of dissolved organic matter: a new graphical analysis of trends.

    PubMed

    Abdulla, Hussain A N; Sleighter, Rachel L; Hatcher, Patrick G

    2013-04-16

    Two-dimensional (2D) correlation analysis was applied to 20 Fourier transform ion cyclotron resonance mass spectra (FTICR-MS) of ultrafiltered dissolved organic matter samples from a salinity transect of the lower Chesapeake Bay. We were able to investigate the chemical changes in the dissolved organic matter pool at the molecular level and classify the individual peaks based on their biogeochemical reactivity. The power of this technique is its ability to be used on either the presence/absence of the individual peaks or their normalized magnitudes. The presence or absence of the peaks are utilized to identify the reactivity and correlation between peaks that plot in different regions of the van Krevelen diagram, whereas the normalized magnitudes are used to correlate the changes among individual peaks. One of the promising advantages of 2D correlation of FTICR-MS data is the ability to associate the variations of the individual peaks with the changes in the functional groups that are measured by other spectroscopic techniques. This approach takes us one step further from identifying molecular formulas to proposing chemical structures. PMID:23472832

  7. An Asymptotic Analysis of a 2-D Model of Dynamically Active Compartments Coupled by Bulk Diffusion

    NASA Astrophysics Data System (ADS)

    Gou, J.; Ward, M. J.

    2016-04-01

    A class of coupled cell-bulk ODE-PDE models is formulated and analyzed in a two-dimensional domain, which is relevant to studying quorum-sensing behavior on thin substrates. In this model, spatially segregated dynamically active signaling cells of a common small radius ɛ ≪ 1 are coupled through a passive bulk diffusion field. For this coupled system, the method of matched asymptotic expansions is used to construct steady-state solutions and to formulate a spectral problem that characterizes the linear stability properties of the steady-state solutions, with the aim of predicting whether temporal oscillations can be triggered by the cell-bulk coupling. Phase diagrams in parameter space where such collective oscillations can occur, as obtained from our linear stability analysis, are illustrated for two specific choices of the intracellular kinetics. In the limit of very large bulk diffusion, it is shown that solutions to the ODE-PDE cell-bulk system can be approximated by a finite-dimensional dynamical system. This limiting system is studied both analytically, using a linear stability analysis and, globally, using numerical bifurcation software. For one illustrative example of the theory, it is shown that when the number of cells exceeds some critical number, i.e., when a quorum is attained, the passive bulk diffusion field can trigger oscillations through a Hopf bifurcation that would otherwise not occur without the coupling. Moreover, for two specific models for the intracellular dynamics, we show that there are rather wide regions in parameter space where these triggered oscillations are synchronous in nature. Unless the bulk diffusivity is asymptotically large, it is shown that a diffusion-sensing behavior is possible whereby more clustered spatial configurations of cells inside the domain lead to larger regions in parameter space where synchronous collective oscillations between the small cells can occur. Finally, the linear stability analysis for these cell

  8. An Asymptotic Analysis of a 2-D Model of Dynamically Active Compartments Coupled by Bulk Diffusion

    NASA Astrophysics Data System (ADS)

    Gou, J.; Ward, M. J.

    2016-08-01

    A class of coupled cell-bulk ODE-PDE models is formulated and analyzed in a two-dimensional domain, which is relevant to studying quorum-sensing behavior on thin substrates. In this model, spatially segregated dynamically active signaling cells of a common small radius ɛ ≪ 1 are coupled through a passive bulk diffusion field. For this coupled system, the method of matched asymptotic expansions is used to construct steady-state solutions and to formulate a spectral problem that characterizes the linear stability properties of the steady-state solutions, with the aim of predicting whether temporal oscillations can be triggered by the cell-bulk coupling. Phase diagrams in parameter space where such collective oscillations can occur, as obtained from our linear stability analysis, are illustrated for two specific choices of the intracellular kinetics. In the limit of very large bulk diffusion, it is shown that solutions to the ODE-PDE cell-bulk system can be approximated by a finite-dimensional dynamical system. This limiting system is studied both analytically, using a linear stability analysis and, globally, using numerical bifurcation software. For one illustrative example of the theory, it is shown that when the number of cells exceeds some critical number, i.e., when a quorum is attained, the passive bulk diffusion field can trigger oscillations through a Hopf bifurcation that would otherwise not occur without the coupling. Moreover, for two specific models for the intracellular dynamics, we show that there are rather wide regions in parameter space where these triggered oscillations are synchronous in nature. Unless the bulk diffusivity is asymptotically large, it is shown that a diffusion-sensing behavior is possible whereby more clustered spatial configurations of cells inside the domain lead to larger regions in parameter space where synchronous collective oscillations between the small cells can occur. Finally, the linear stability analysis for these cell

  9. Simulated bipolar cells in fovea of human retina. V. Use of Fourier analysis to determine resolution.

    PubMed

    Siminoff, R

    1991-01-01

    Fourier analysis is used to study resolution of images processed by the matrix of simulated red-center (BCR) and green-center (BCG) bipolar cells (BC) of the human central fovea. Simulated achromatic and chromatic sine and square waves, and a two-bar stimulus are used to activate the BCs. Due to the "honeycomb" packing of the cones and BC matrices Fourier transforms are computed row by row using a one-dimensional FFT. Resolution computed by the Fourier transform is compared with the resolution index (RI), which is a method for determining resolution based on two-point discrimination in the space domain. In general the harmonic with the maximum amplitude gives the best correlation with RI for the three stimuli. Amplitudes at all spatial frequencies are enhanced by increasing the number of cycles in the sine and square wave gratings. Results with simulated BCs compare favorably with human and macaque psychophysics measuring contrast sensitivity. Square wave gratings are better than sine wave greetings for studying resolution. PMID:1768719

  10. Spectral analysis comparisons of Fourier-theory-based methods and minimum variance (Capon) methods

    NASA Astrophysics Data System (ADS)

    Garbanzo-Salas, Marcial; Hocking, Wayne. K.

    2015-09-01

    In recent years, adaptive (data dependent) methods have been introduced into many areas where Fourier spectral analysis has traditionally been used. Although the data-dependent methods are often advanced as being superior to Fourier methods, they do require some finesse in choosing the order of the relevant filters. In performing comparisons, we have found some concerns about the mappings, particularly when related to cases involving many spectral lines or even continuous spectral signals. Using numerical simulations, several comparisons between Fourier transform procedures and minimum variance method (MVM) have been performed. For multiple frequency signals, the MVM resolves most of the frequency content only for filters that have more degrees of freedom than the number of distinct spectral lines in the signal. In the case of Gaussian spectral approximation, MVM will always underestimate the width, and can misappropriate the location of spectral line in some circumstances. Large filters can be used to improve results with multiple frequency signals, but are computationally inefficient. Significant biases can occur when using MVM to study spectral information or echo power from the atmosphere. Artifacts and artificial narrowing of turbulent layers is one such impact.

  11. Multi-level model for 2D human motion analysis and description

    NASA Astrophysics Data System (ADS)

    Foures, Thomas; Joly, Philippe

    2003-01-01

    This paper deals with the proposition of a model for human motion analysis in a video. Its main caracteristic is to adapt itself automatically to the current resolution, the actual quality of the picture, or the level of precision required by a given application, due to its possible decomposition into several hierarchical levels. The model is region-based to address some analysis processing needs. The top level of the model is only defined with 5 ribbons, which can be cut into sub-ribbons regarding to a given (or an expected) level of details. Matching process between model and current picture consists in the comparison of extracted subject shape with a graphical rendering of the model built on the base of some computed parameters. The comparison is processed by using a chamfer matching algorithm. In our developments, we intend to realize a platform of interaction between a dancer and tools synthetizing abstract motion pictures and music in the conditions of a real-time dialogue between a human and a computer. In consequence, we use this model in a perspective of motion description instead of motion recognition: no a priori gestures are supposed to be recognized as far as no a priori application is specially targeted. The resulting description will be made following a Description Scheme compliant with the movement notation called "Labanotation".

  12. Multiscale quantification of morphodynamics: MorphoLeaf software for 2D shape analysis.

    PubMed

    Biot, Eric; Cortizo, Millán; Burguet, Jasmine; Kiss, Annamaria; Oughou, Mohamed; Maugarny-Calès, Aude; Gonçalves, Beatriz; Adroher, Bernard; Andrey, Philippe; Boudaoud, Arezki; Laufs, Patrick

    2016-09-15

    A major challenge in morphometrics is to analyse complex biological shapes formed by structures at different scales. Leaves exemplify this challenge as they combine differences in their overall shape with smaller shape variations at their margin, leading to lobes or teeth. Current methods based on contour or on landmark analysis are successful in quantifying either overall leaf shape or leaf margin dissection, but fail in combining the two. Here, we present a comprehensive strategy and its associated freely available platform for the quantitative, multiscale analysis of the morphology of leaves with different architectures. For this, biologically relevant landmarks are automatically extracted and hierarchised, and used to guide the reconstruction of accurate average contours that properly represent both global and local features. Using this method, we establish a quantitative framework of the developmental trajectory of Arabidopsis leaves of different ranks and retrace the origin of leaf heteroblasty. When applied to different mutant forms, our method can contribute to a better understanding of gene function, as we show here for the role of CUC2 during Arabidopsis leaf serration. Finally, we illustrate the wider applicability of our tool by analysing hand morphometrics. PMID:27387872

  13. 2-D Time-Dependent Fuel Element, Thermal Analysis Code System.

    2001-09-24

    Version 00 WREM-TOODEE2 is a two dimensional, time-dependent, fuel-element thermal analysis program. Its primary purpose is to evaluate fuel-element thermal response during post-LOCA refill and reflood in a pressurized water reactor (PWR). TOODEE2 calculations are carried out in a two-dimensional mesh region defined in slab or cylindrical geometry by orthogonal grid lines. Coordinates which form order pairs are labeled x-y in slab geometry, and those in cylindrical geometry are labeled r-z for the axisymmetric casemore » and r-theta for the polar case. Conduction and radiation are the only heat transfer mechanisms assumed within the boundaries of the mesh region. Convective and boiling heat transfer mechanisms are assumed at the boundaries. The program numerically solves the two-dimensional, time-dependent, heat conduction equation within the mesh region. KEYWORDS: FUEL MANAGEMENT; HEAT TRANSFER; LOCA; PWR« less

  14. UCF WASTE PACKAGE SHIELDING ANALYSIS/2-D DORT (SCPB: N/A)

    SciTech Connect

    D.J. Skulina

    1996-01-18

    This analysis is prepared by the Mined Geologic Disposal System (MGDS) Waste Package Development Department (WPDD) to determine the dose rates from the UCF waste packages to be used by the EBS and other repository systems to incorporate ALARA practices in the overall repository design in compliance with the goals of the Waste Package Implementation Plan for conceptual design. These design calculations are performed in sufficient detail to provide a comprehensive comparison base with other design alternatives. The objectives of this evaluation are (1) to show the dose rate as a function of distance from the waste package surface and (2) to provide the shielding thicknesses required for the waste package transporter to meet a 10 mr/hr target dose rate at 2 meters from the transporter surface.

  15. High pH reversed-phase chromatography with fraction concatenation for 2D proteomic analysis

    SciTech Connect

    Yang, Feng; Shen, Yufeng; Camp, David G.; Smith, Richard D.

    2012-04-01

    Orthogonal high-resolution separations are critical for attaining improved analytical dynamic ranges of proteome measurements. Concatenated high pH reversed phase liquid chromatography affords better separations than the strong cation exchange conventionally applied for two-dimensional shotgun proteomic analysis. For example, concatenated high pH reversed phase liquid chromatography increased identification coverage for peptides (e.g., by 1.8-fold) and proteins (e.g., by 1.6-fold) in shotgun proteomics analyses of a digested human protein sample. Additional advantages of concatenated high pH RPLC include improved protein sequence coverage, simplified sample processing, and reduced sample losses, making this an attractive first dimension separation strategy for two-dimensional proteomics analyses.

  16. Quantitative analysis of molecular-level DNA crystal growth on a 2D surface

    PubMed Central

    Lee, Junwye; Hamada, Shogo; Hwang, Si Un; Amin, Rashid; Son, Junyoung; Dugasani, Sreekantha Reddy; Murata, Satoshi; Park, Sung Ha

    2013-01-01

    Crystallization is an essential process for understanding a molecule's aggregation behavior. It provides basic information on crystals, including their nucleation and growth processes. Deoxyribonucleic acid (DNA) has become an interesting building material because of its remarkable properties for constructing various shapes of submicron-scale DNA crystals by self-assembly. The recently developed substrate-assisted growth (SAG) method produces fully covered DNA crystals on various substrates using electrostatic interactions and provides an opportunity to observe the overall crystallization process. In this study, we investigated quantitative analysis of molecular-level DNA crystallization using the SAG method. Coverage and crystal size distribution were studied by controlling the external parameters such as monomer concentration, annealing temperature, and annealing time. Rearrangement during crystallization was also discussed. We expect that our study will provide overall picture of the fabrication process of DNA crystals on the charged substrate and promote practical applications of DNA crystals in science and technology. PMID:23817625

  17. Proteomic analysis of heat treated bitter gourd (Momordica charantia L. var. Hong Kong Green) using 2D-DIGE.

    PubMed

    Ng, Zhi Xiang; Chua, Kek Heng; Kuppusamy, Umah Rani

    2014-04-01

    This study aimed to investigate the changes in the proteome of bitter gourd prior to and after subjecting to boiling and microwaving. A comparative analysis of the proteome profiles of raw and thermally treated bitter gourds was performed using 2D-DIGE. The protein content and number of protein spots in raw sample was higher when compared to the cooked samples. Qualitative analysis revealed that 103 (boiled sample) and 110 (microwaved sample) protein spots were up regulated whereas 120 (boiled sample) and 107 (microwaved sample) protein spots were down regulated. Ten protein spots with the highest significant fold change in the cooked samples were involved in carbohydrate/energy metabolisms and stress responses. Small heat shock proteins, superoxide dismutase, quinone oxidoreductase, UDP-glucose pyrophosphorylase and phosphoglycerate kinase play a role in heat-stress-mediated protection of bitter gourd. This study suggests that appropriate heat treatment (cooking methods) can lead to induction of selected proteins in bitter gourd. PMID:24262540

  18. 2D-PAGE protein analysis of dinoflagellate Alexandrium minutum based on three different temperatures

    NASA Astrophysics Data System (ADS)

    Latib, Norhidayu Abdul; Norshaha, Safida Anira; Usup, Gires; Yusof, Nurul Yuziana Mohd

    2015-09-01

    Harmful algae bloom or red tide seems to be considered as threat to ecosystem, especially to human consumption because of the production of neurotoxin by dinoflagellates species such as Alexandrium minutum which can lead to paralytic shellfish poisoning. The aim of this study is to determine the most suitable method for protein extraction of A. minutum followed by determination of differential protein expression of A. minutum on three different temperatures (15°C, 26°C and 31.5°C). After the optimization, the protein extract was subjected to two-dimensional polyacrylamide gel electrophoresis (2-DE) to compare the intensity and distribution of the protein spots. Based on quantitative and qualitative protein assessment, use of Trizol reagent is the most suitable method to extract protein from A. minutum. 2-DE analysis of the samples results in different distribution and intensity of the protein spots were compared between 15°C, 26°C and 31.5°C.

  19. A 2-D Interface Element for Coupled Analysis of Independently Modeled 3-D Finite Element Subdomains

    NASA Technical Reports Server (NTRS)

    Kandil, Osama A.

    1998-01-01

    Over the past few years, the development of the interface technology has provided an analysis framework for embedding detailed finite element models within finite element models which are less refined. This development has enabled the use of cascading substructure domains without the constraint of coincident nodes along substructure boundaries. The approach used for the interface element is based on an alternate variational principle often used in deriving hybrid finite elements. The resulting system of equations exhibits a high degree of sparsity but gives rise to a non-positive definite system which causes difficulties with many of the equation solvers in general-purpose finite element codes. Hence the global system of equations is generally solved using, a decomposition procedure with pivoting. The research reported to-date for the interface element includes the one-dimensional line interface element and two-dimensional surface interface element. Several large-scale simulations, including geometrically nonlinear problems, have been reported using the one-dimensional interface element technology; however, only limited applications are available for the surface interface element. In the applications reported to-date, the geometry of the interfaced domains exactly match each other even though the spatial discretization within each domain may be different. As such, the spatial modeling of each domain, the interface elements and the assembled system is still laborious. The present research is focused on developing a rapid modeling procedure based on a parametric interface representation of independently defined subdomains which are also independently discretized.

  20. Morphometric structural diversity of a natural armor assembly investigated by 2D continuum strain analysis.

    PubMed

    Varshney, Swati; Song, Juha; Li, Yaning; Boyce, Mary C; Ortiz, Christine

    2015-12-01

    Many armored fish scale assemblies use geometric heterogeneity of subunits as a design parameter to provide tailored biomechanical flexibility while maintaining protection from external penetrative threats. This study analyzes the spatially varying shape of individual ganoid scales as a structural element in a biological system, the exoskeleton of the armored fish Polypterus senegalus (bichir). X-ray microcomputed tomography is used to generate digital 3D reconstructions of the mineralized scales. Landmark-based geometric morphometrics is used to measure the geometric variation among scales and to define a set of geometric parameters to describe shape variation. A formalism using continuum mechanical strain analysis is developed to quantify the spatial geometry change of the scales and illustrate the mechanisms of shape morphing between scales. Five scale geometry variants are defined (average, anterior, tail, ventral, and pectoral fin) and their functional implications are discussed in terms of the interscale mobility mechanisms that enable flexibility within the exoskeleton. The results suggest that shape variation in materials design, inspired by structural biological materials, can allow for tunable behavior in flexible composites made of segmented scale assemblies to achieve enhanced user mobility, custom fit, and flexibility around joints for a variety of protective applications. PMID:26481418

  1. Scaling Analysis of Ocean Surface Turbulent Heterogeneities from Satellite Remote Sensing: Use of 2D Structure Functions

    PubMed Central

    Renosh, P. R.; Schmitt, Francois G.; Loisel, Hubert

    2015-01-01

    Satellite remote sensing observations allow the ocean surface to be sampled synoptically over large spatio-temporal scales. The images provided from visible and thermal infrared satellite observations are widely used in physical, biological, and ecological oceanography. The present work proposes a method to understand the multi-scaling properties of satellite products such as the Chlorophyll-a (Chl-a), and the Sea Surface Temperature (SST), rarely studied. The specific objectives of this study are to show how the small scale heterogeneities of satellite images can be characterised using tools borrowed from the fields of turbulence. For that purpose, we show how the structure function, which is classically used in the frame of scaling time series analysis, can be used also in 2D. The main advantage of this method is that it can be applied to process images which have missing data. Based on both simulated and real images, we demonstrate that coarse-graining (CG) of a gradient modulus transform of the original image does not provide correct scaling exponents. We show, using a fractional Brownian simulation in 2D, that the structure function (SF) can be used with randomly sampled couple of points, and verify that 1 million of couple of points provides enough statistics. PMID:26017551

  2. MIA-QSAR: a simple 2D image-based approach for quantitative structure activity relationship analysis

    NASA Astrophysics Data System (ADS)

    Freitas, Matheus P.; Brown, Steven D.; Martins, José A.

    2005-03-01

    An accessible and quite simple QSAR method, based on 2D image analysis, is reported. A case study is carried out in order to compare this model with a previously reported sophisticated methodology. A well known set of ( S)- N-[(1-ethyl-2-pyrrolidinyl)methyl]-6-methoxybenzamides, compounds with affinity to the dopamine D 2 receptor subtype, was divided in 40 calibration compounds and 18 test compounds and the descriptors were generated from pixels of 2D structures of each compound, which can be drawn with aid of any appropriate program. Bilinear (conventional) PLS was utilized as the regression method and leave-one-out cross-validation was performed using the NIPALS algorithm. The good predicted Q2 value obtained for the series of test compounds (0.58), together with the similar prediction quality obtained to other data sets (nAChR ligands, HIV protease inhibitors, COX-2 inhibitors and anxiolytic agents), suggests that the model is robust and seems to be as applicable as more complex methods.

  3. Scaling Analysis of Ocean Surface Turbulent Heterogeneities from Satellite Remote Sensing: Use of 2D Structure Functions.

    PubMed

    Renosh, P R; Schmitt, Francois G; Loisel, Hubert

    2015-01-01

    Satellite remote sensing observations allow the ocean surface to be sampled synoptically over large spatio-temporal scales. The images provided from visible and thermal infrared satellite observations are widely used in physical, biological, and ecological oceanography. The present work proposes a method to understand the multi-scaling properties of satellite products such as the Chlorophyll-a (Chl-a), and the Sea Surface Temperature (SST), rarely studied. The specific objectives of this study are to show how the small scale heterogeneities of satellite images can be characterised using tools borrowed from the fields of turbulence. For that purpose, we show how the structure function, which is classically used in the frame of scaling time series analysis, can be used also in 2D. The main advantage of this method is that it can be applied to process images which have missing data. Based on both simulated and real images, we demonstrate that coarse-graining (CG) of a gradient modulus transform of the original image does not provide correct scaling exponents. We show, using a fractional Brownian simulation in 2D, that the structure function (SF) can be used with randomly sampled couple of points, and verify that 1 million of couple of points provides enough statistics. PMID:26017551

  4. Combined analysis of 2-D electrical resistivity, seismic refraction and geotechnical investigations for Bukit Bunuh complex crater

    NASA Astrophysics Data System (ADS)

    Azwin, I. N.; Saad, Rosli; Saidin, Mokhtar; Nordiana, M. M.; Anderson Bery, Andy; Hidayah, I. N. E.

    2015-01-01

    Interest in studying impact crater on earth has increased tremendously due to its importance in geologic events, earth inhabitant history as well as economic value. The existences of few shock metamorphism and crater morphology evidences are discovered in Bukit Bunuh, Malaysia thus detailed studies are performed using geophysical and geotechnical methods to verify the type of the crater and characteristics accordingly. This paper presents the combined analysis of 2-D electrical resistivity, seismic refraction, geotechnical SPT N value, moisture content and RQD within the study area. Three stages of data acquisition are made starting with regional study followed by detailed study on West side and East side. Bulk resistivity and p-wave seismic velocity were digitized from 2-D resistivity and seismic sections at specific distance and depth for corresponding boreholes and samples taken. Generally, Bukit Bunuh shows the complex crater characteristics. Standard table of bulk resistivity and p-wave seismic velocity against SPT N value, moisture content and RQD are produce according to geological classifications of impact crater; inside crater, rim/slumped terrace and outside crater.

  5. Fourier spatial frequency analysis for image classification: training the training set

    NASA Astrophysics Data System (ADS)

    Johnson, Timothy H.; Lhamo, Yigah; Shi, Lingyan; Alfano, Robert R.; Russell, Stewart

    2016-04-01

    The Directional Fourier Spatial Frequencies (DFSF) of a 2D image can identify similarity in spatial patterns within groups of related images. A Support Vector Machine (SVM) can then be used to classify images if the inter-image variance of the FSF in the training set is bounded. However, if variation in FSF increases with training set size, accuracy may decrease as the size of the training set increases. This calls for a method to identify a set of training images from among the originals that can form a vector basis for the entire class. Applying the Cauchy product method we extract the DFSF spectrum from radiographs of osteoporotic bone, and use it as a matched filter set to eliminate noise and image specific frequencies, and demonstrate that selection of a subset of superclassifiers from within a set of training images improves SVM accuracy. Central to this challenge is that the size of the search space can become computationally prohibitive for all but the smallest training sets. We are investigating methods to reduce the search space to identify an optimal subset of basis training images.

  6. Stress analysis of a rectangular implant in laminated composites using 2-D and 3-D finite elements

    NASA Technical Reports Server (NTRS)

    Chow, Wai T.; Graves, Michael J.

    1992-01-01

    An analysis method using the FEM based on the Hellinger-Reissner variation principle has been developed to determine the 3-D stresses and displacements near a rectangular implant inside a laminated composite material. Three-dimensional elements are employed in regions where the interlaminar stress is considered to be significant; 2-D elements are used in other areas. Uniaxially loaded graphite-epoxy laminates have been analyzed; the implant was modeled as four plies of 3501/6 epoxy located in the middle of the laminate. It is shown that the interlaminar stresses are an order of magnitude lower than the stress representing the applied far-field load. The stress concentration factors of both the interlaminar and in-plane stresses depend on the stacking sequence of the laminate.

  7. Relevance of 2D radiographic texture analysis for the assessment of 3D bone micro-architecture

    SciTech Connect

    Apostol, Lian; Boudousq, Vincent; Basset, Oliver; Odet, Christophe; Yot, Sophie; Tabary, Joachim; Dinten, Jean-Marc; Boller, Elodie; Kotzki, Pierre-Olivier; Peyrin, Francoise

    2006-09-15

    Although the diagnosis of osteoporosis is mainly based on dual x-ray absorptiometry, it has been shown that trabecular bone micro-architecture is also an important factor in regard to fracture risk. In vivo, techniques based on high-resolution x-ray radiography associated to texture analysis have been proposed to investigate bone micro-architecture, but their relevance for giving pertinent 3D information is unclear. Thirty-three calcaneus and femoral neck bone samples including the cortical shells (diameter: 14 mm, height: 30-40 mm) were imaged using 3D-synchrotron x-ray micro-CT at the ESRF. The 3D reconstructed images with a cubic voxel size of 15 {mu}m were further used for two purposes: (1) quantification of three-dimensional trabecular bone micro-architecture (2) simulation of realistic x-ray radiographs under different acquisition conditions. The simulated x-ray radiographs were then analyzed using a large variety of texture analysis methods (co-occurrence, spectral density, fractal, morphology, etc.). The range of micro-architecture parameters was in agreement with previous studies and rather large, suggesting that the population was representative. More than 350 texture parameters were tested. A small number of them were selected based on their correlation to micro-architectural morphometric parameters. Using this subset of texture parameters, multiple regression allowed one to predict up to 93% of the variance of micro-architecture parameters using three texture features. 2D texture features predicting 3D micro-architecture parameters other than BV/TV were identified. The methodology proposed for evaluating the relationships between 3D micro-architecture and 2D texture parameters may also be used for optimizing the conditions for radiographic imaging. Further work will include the application of the method to physical radiographs. In the future, this approach could be used in combination with DXA to refine osteoporosis diagnosis.

  8. High divergent 2D grating

    NASA Astrophysics Data System (ADS)

    Wang, Jin; Ma, Jianyong; Zhou, Changhe

    2014-11-01

    A 3×3 high divergent 2D-grating with period of 3.842μm at wavelength of 850nm under normal incidence is designed and fabricated in this paper. This high divergent 2D-grating is designed by the vector theory. The Rigorous Coupled Wave Analysis (RCWA) in association with the simulated annealing (SA) is adopted to calculate and optimize this 2D-grating.The properties of this grating are also investigated by the RCWA. The diffraction angles are more than 10 degrees in the whole wavelength band, which are bigger than the traditional 2D-grating. In addition, the small period of grating increases the difficulties of fabrication. So we fabricate the 2D-gratings by direct laser writing (DLW) instead of traditional manufacturing method. Then the method of ICP etching is used to obtain the high divergent 2D-grating.

  9. Fourier analysis of planimetric lunar crater shape - Possible guide to impact history and lunar geology

    NASA Technical Reports Server (NTRS)

    Eppler, D. T.; Nummedal, D.; Ehrlich, R.

    1977-01-01

    If the lithology of lunar crust influences impact crater morphology, a method of analysis that is sensitive to small-scale changes in crater shape is required. In the present paper, it is shown that Fourier analysis in closed form can provide detailed information regarding planimetric crater shape. Preliminary analysis of the rim crest outline of 247 nearside lunar craters (larger than 18 km in diam) led to the following information: Imbrian and pre-Imbrian craters are more elongate than younger craters, possibly as a result of widespread crustal deformation early in the moon's history. Crater size does not affect the planimetric shape of craters. Highland craters are less circular than mare craters, probably due to the greater structural and lithologic complexity of the highland crust. Craters comprising each shape family of the eleventh harmonic typically are located in the same general geographic region of the moon.

  10. Fourier transform infrared spectroscopy techniques for the analysis of drugs of abuse

    NASA Astrophysics Data System (ADS)

    Kalasinsky, Kathryn S.; Levine, Barry K.; Smith, Michael L.; Magluilo, Joseph J.; Schaefer, Teresa

    1994-01-01

    Cryogenic deposition techniques for Gas Chromatography/Fourier Transform Infrared (GC/FT-IR) can be successfully employed in urinalysis for drugs of abuse with detection limits comparable to those of the established Gas Chromatography/Mass Spectrometry (GC/MS) technique. The additional confidence of the data that infrared analysis can offer has been helpful in identifying ambiguous results, particularly, in the case of amphetamines where drugs of abuse can be confused with over-the-counter medications or naturally occurring amines. Hair analysis has been important in drug testing when adulteration of urine samples has been a question. Functional group mapping can further assist the analysis and track drug use versus time.

  11. Geometric phase analysis based on the windowed Fourier transform for the deformation field measurement

    NASA Astrophysics Data System (ADS)

    Dai, Xianglu; Xie, Huimin; Wang, Qinghua

    2014-06-01

    The geometric phase analysis (GPA), an important image-based deformation measurement method, has been used at both micro- and nano-scale. However, when a deformed image has apparent distortion, non-ignorable error in the obtained deformation field could occur by using this method. In this paper, the geometric phase analysis based on the windowed Fourier transform (WFT) is proposed to solve the above-mentioned issue, defined as the WFT-GPA method. In WFT-GPA, instead of the Fourier transform (FT), the WFT is utilized to extract the phase field block by block, and therefore more accurate local phase information can be acquired. The simulation tests, which include detailed discussion of influence factors for measurement accuracy such as window size and image noise, are conducted with digital deformed grids. The results verify that the WFT-GPA method not only keeps all advantages of traditional GPA method, but also owns a better accuracy for deformation measurement. Finally, the WFT-GPA method is applied to measure the machining distortion incurred in soft ultraviolet nanoimprint lithography (UV-NIL) process. The successful measurement shows the feasibility of this method and offers a full-field way for characterizing the replication quality of UV-NIL process.

  12. Assessment of vasomotor oscillations with Fourier analysis of biological tissue impedance

    NASA Astrophysics Data System (ADS)

    Nesterov, A.; Gavrilov, I.; Selector, L.; Mudraya, I.; Revenko, S.

    2010-04-01

    Fourier analysis revealed a number of periodicities in small variations of bioimpedance of human finger including the major spectrum peaks at the frequencies of heart beats, respiration, and Mayer wave (0.1 Hz). These periodic variations of bioimpedance were detected under the normal conditions and during blood flow arrest in the hand by a pneumatic cuff placed on the arm. They are explained by periodic variations in systemic blood pressure and by oscillations of regional vascular tone resulted from neural vasomotor control. During normal blood flow, the greatest variations in bioimpedance were observed at the heart rate, and their amplitude surpassed by an order of magnitude the amplitudes of respiratory oscillations and Mayer wave. In contrast, during blood arrest, the largest amplitude of rhythmical changes of the impedance characterized the oscillations at respiration rate, while the amplitude of oscillations at the heart rate was the smallest. During normal respiration and circulation, two side cardiac peaks were revealed in bioimpedance amplitude spectrum which disappeared during respiration arrest and thought to reflect the amplitude respiratory modulation of the cardiac output via sympathetic influences. During normal breathing, the second and the third harmonics of the cardiac spectrum peak were split reflecting frequency respiratory modulation of the heart rate by parasympathetic influences. The results favour applicability of Fourier analysis of bioimpedance variations in assessment of regional neural influences and neurogenic modulation of cardiac activity.

  13. Quantitative Fourier transform infrared analysis of gas phase cigarette smoke and other gas mixtures

    SciTech Connect

    Cueto, R.; Church, D.F.; Pryor, W.A. )

    1989-03-01

    A new method for the analysis of selected components in complex gas mixtures has been developed utilizing a relatively inexpensive Fourier transform infrared spectrometer and a continuous flow gas cell. The method was used to monitor nitric oxide and nitrogen dioxide concentrations in cigarette smoke with time. Using multivariate least-square regression analysis, it is possible to simultaneously quantitate both NO and NO{sub 2}, even in the presence of overlapping peaks. Using this method, the oxidation of nitric oxide in the presence of isoprene in cigarette smoke and in a model system was followed with time. The method also can be applied to other compounds in smoke or to any other gaseous mixture.

  14. [Application of Fourier transform attenuated total reflection infrared spectroscopy in analysis of pulp and paper industry].

    PubMed

    Zhang, Yong; Cao, Chun-yu; Feng, Wen-ying; Xu, Ming; Su, Zhen-hua; Liu, Xiao-meng; Lü, Wei-jun

    2011-03-01

    As one of the most powerful tools to investigate the compositions of raw materials and the property of pulp and paper, infrared spectroscopy has played an important role in pulp and paper industry. However, the traditional transmission infrared spectroscopy has not met the requirements of the producing processes because of its disadvantages of time consuming and sample destruction. New technique would be needed to be found. Fourier transform attenuated total reflection infrared spectroscopy (ATR-FTIR) is an advanced spectroscopic tool for nondestructive evaluation and could rapidly, accurately estimate the production properties of each process in pulp and paper industry. The present review describes the application of ATR-FTIR in analysis of pulp and paper industry. The analysis processes will include: pulping, papermaking, environmental protecting, special processing and paper identifying. PMID:21595211

  15. Diamond cell Fourier transform infrared spectroscopy transmittance analysis of black toners on questioned documents.

    PubMed

    Assis, A C Almeida; Barbosa, M F; Nabais, J M Valente; Custódio, A F; Tropecelo, P

    2012-01-10

    This paper describes the use of a diamond cell Fourier transform infrared (FTIR) spectroscopy methodology for the analysis of black toners commercialised in Portugal. A total of one hundred and thirty-eight samples from eighteen manufacturers were analysed in transmittance mode through a diamond cell. This methodology was considered to be non-destructive as it allows the forensic analysis of the questioned documents while preserving their integrity. The questioned documents' substrate (paper sheets) has no influence on the final result. This technique shows high repeatability and intermediate precision. Spectra were organized in twenty distinct groups based on their main chemical characteristics and relative peak intensity; and a black toner infrared spectral library was developed. Spectral matches between forty-five blind samples and the database resulted in a 100% positive identification to the correct group. PMID:21831548

  16. Measurement of absolute optical thickness of mask glass by wavelength-tuning Fourier analysis.

    PubMed

    Kim, Yangjin; Hbino, Kenichi; Sugita, Naohiko; Mitsuishi, Mamoru

    2015-07-01

    Optical thickness is a fundamental characteristic of an optical component. A measurement method combining discrete Fourier-transform (DFT) analysis and a phase-shifting technique gives an appropriate value for the absolute optical thickness of a transparent plate. However, there is a systematic error caused by the nonlinearity of the phase-shifting technique. In this research the absolute optical-thickness distribution of mask blank glass was measured using DFT and wavelength-tuning Fizeau interferometry without using sensitive phase-shifting techniques. The error occurring during the DFT analysis was compensated for by using the unwrapping correlation. The experimental results indicated that the absolute optical thickness of mask glass was measured with an accuracy of 5 nm. PMID:26125394

  17. Fourier mode analysis of slab-geometry transport iterations in spatially periodic media

    SciTech Connect

    Larsen, E W; Zika, M R

    1999-05-07

    We describe a Fourier analysis of the diffusion-synthetic acceleration (DSA) and transport-synthetic acceleration (TSA) iteration schemes for a spatially periodic, but otherwise arbitrarily heterogeneous, medium. Both DSA and TSA converge more slowly in a heterogeneous medium than in a homogeneous medium composed of the volume-averaged scattering ratio. In the limit of a homogeneous medium, our heterogeneous analysis contains eigenvalues of multiplicity two at ''resonant'' wave numbers. In the presence of material heterogeneities, error modes corresponding to these resonant wave numbers are ''excited'' more than other error modes. For DSA and TSA, the iteration spectral radius may occur at these resonant wave numbers, in which case the material heterogeneities most strongly affect iterative performance.

  18. Fourier mode analysis of slab-geometry transport iterations in spatially periodic media

    SciTech Connect

    Larsen, E; Zika, M

    1999-04-01

    We describe a Fourier analysis of the diffusion-synthetic acceleration (DSA) and transport-synthetic acceleration (TSA) iteration schemes for a spatially periodic, but otherwise arbitrarily heterogeneous, medium. Both DSA and TSA converge more slowly in a heterogeneous medium than in a homogeneous medium composed of the volume-averaged scattering ratio. In the limit of a homogeneous medium, our heterogeneous analysis contains eigenvalues of multiplicity two at ''resonant'' wave numbers. In the presence of material heterogeneities, error modes corresponding to these resonant wave numbers are ''excited'' more than other error modes. For DSA and TSA, the iteration spectral radius may occur at these resonant wave numbers, in which case the material heterogeneities most strongly affect iterative performance.

  19. Requirements Formulation and Dynamic Jitter Analysis for Fourier-Kelvin Stellar Interferometer

    NASA Technical Reports Server (NTRS)

    Liu, Kuo-Chia; Hyde, Tristram; Blaurock, Carl; Bolognese, Jeff; Howard, Joseph; Danchi, William

    2004-01-01

    The Fourier-Kelvin Stellar Interferometer (FKSI) has been proposed to detect and characterize extra solar giant planets. The baseline configuration for FKSI is a two- aperture, structurally connected nulling interferometer, capable of providing null depth less than lo4 in the infrared. The objective of this paper is to summarize the process for setting the top level requirements and the jitter analysis performed on FKSI to date. The first part of the paper discusses the derivation of dynamic stability requirements, necessary for meeting the FKSI nulling demands. An integrated model including structures, optics, and control systems has been developed to support dynamic jitter analysis and requirements verification. The second part of the paper describes how the integrated model is used to investigate the effects of reaction wheel disturbances on pointing and optical path difference stabilities.

  20. Identification of Bacterial Spores using Statistical Analysis of Fourier Transform Infrared Photoacoustic Spectroscopy Data

    SciTech Connect

    Thompson, Sandra E.; Foster, Nancy S.; Johnson, Timothy J.; Valentine, Nancy B.; Amonette, James E.

    2003-08-28

    Fourier Transform Infrared Photoacoustic Spectroscopy (FTIR-PAS) has been applied for the first time to the identification and speciation of bacterial spores. With minimal preparation the spores were deposited into the photoacoustic sample cup and their spectra recorded. A total of 40 different samples of 5 different strains of Bacillus spores were analyzed: Bacillus subtilis ATCC 49760, Bacillus atrophaeus ATCC 49337, Bacillus subtilis 6051, Bacillus thuringiensis ssp. kurstaki, and Bacillus globigii Dugway. The statistical methods used included principal-component analysis (PCA), classification and regression trees (CART), and Mahalanobis-distance calculations. Internal cross-validation studies successfully classify the spores according to their bacterial strain in 38 of 40 cases (95%) and 36 of 40 (90%) in cross-validation. Analysis of fifteen blind samples, which included library and other spores, and nonbacterial materials, resulted in correct strain classification the blind samples that were members of the library and correct rejection of the nonbacterial samples.

  1. Analysis of fractal and fast fourier transform spectra of human electroencephalograms induced by odors.

    PubMed

    Murali, S; Vladimir, Kulish V

    2007-10-01

    Fast Fourier transform (FFT) and fractal dimension (FD) are computed to discover the evoked potentials (EPs) in the base human electroencephalograms (EEGs) corresponding to six types of odor inhalation, one at a time. During the first 20 s of the EEG recording, the patient breathes normally and the rest of the recording time 21-64 s, inhales an odor, when both the eye open and closed modes. FFT spectral analysis cannot discriminate the potential due to olfactory stimuli from the base EEG. However, fractal spectra analysis predicts the evoked potential due to inhalation of English rose, jasmine, lemon, orange, rose garden, and sandalwood concentrates. Similar results are obtained for three of the patients examined and on computing for five EEG recordings of two patients during inhalation of six types of odor. PMID:17729151

  2. A hybrid wave-mode formulation for the vibro-acoustic analysis of 2D periodic structures

    NASA Astrophysics Data System (ADS)

    Droz, C.; Zhou, C.; Ichchou, M. N.; Lainé, J.-P.

    2016-02-01

    In the framework of vibrational analysis of 2D periodic waveguides, Floquet-Bloch theorem is widely applied for the determination of wave dispersion characteristics. In this context, the Wave Finite Element Method (WFEM) combines Periodic Structure Theory (PST) with standard FE packages, enabling wave dispersion analysis of waveguides involving structurally realistic unit-cells. For such applications, the computational efficiency of the WFEM depends on the choice of the formulation and can lead to numerical issues, worsen by extensive computational cost. This paper presents a coupled wave-mode approach for the determination of wave dispersion characteristics in structurally advanced periodic structures. It combines two scales of model order reduction. At the unit-cell's scale, Component Mode Synthesis (CMS) provides the displacement field associated with local resonances of the periodic structure, while the free wave propagation is considered using a spectral problem projection on a reduced set of shape functions associated with propagating waves, thus providing considerable reduction of the computational cost. An application is provided for a bi-directionally stiffened panel and the influence of reduction parameters is discussed, as well as the robustness of the numerical results.

  3. New aQTL SNPs for the CYP2D6 Identified by a Novel Mediation Analysis of Genome-Wide SNP Arrays, Gene Expression Arrays, and CYP2D6 Activity

    PubMed Central

    Wang, Zhiping; Boustani, Malaz; Liu, Yunlong; Skaar, Todd; Li, Lang

    2013-01-01

    Background. The genome-wide association studies (GWAS) have been successful during the last few years. A key challenge is that the interpretation of the results is not straightforward, especially for transacting SNPs. Integration of transcriptome data into GWAS may provide clues elucidating the mechanisms by which a genetic variant leads to a disease. Methods. Here, we developed a novel mediation analysis approach to identify new expression quantitative trait loci (eQTL) driving CYP2D6 activity by combining genotype, gene expression, and enzyme activity data. Results. 389,573 and 1,214,416 SNP-transcript-CYP2D6 activity trios are found strongly associated (P < 10−5, FDR = 16.6% and 11.7%) for two different genotype platforms, namely, Affymetrix and Illumina, respectively. The majority of eQTLs are trans-SNPs. A single polymorphism leads to widespread downstream changes in the expression of distant genes by affecting major regulators or transcription factors (TFs), which would be visible as an eQTL hotspot and can lead to large and consistent biological effects. Overlapped eQTL hotspots with the mediators lead to the discovery of 64 TFs. Conclusions. Our mediation analysis is a powerful approach in identifying the trans-QTL-phenotype associations. It improves our understanding of the functional genetic variations for the liver metabolism mechanisms. PMID:24232670

  4. Fourier transform infrared spectroscopy quantitative analysis of SF6 partial discharge decomposition components.

    PubMed

    Zhang, Xiaoxing; Liu, Heng; Ren, Jiangbo; Li, Jian; Li, Xin

    2015-02-01

    Gas-insulated switchgear (GIS) internal SF6 gas produces specific decomposition components under partial discharge (PD). By detecting these characteristic decomposition components, such information as the type and level of GIS internal insulation deterioration can be obtained effectively, and the status of GIS internal insulation can be evaluated. SF6 was selected as the background gas for Fourier transform infrared spectroscopy (FTIR) detection in this study. SOF2, SO2F2, SO2, and CO were selected as the characteristic decomposition components for system analysis. The standard infrared absorption spectroscopy of the four characteristic components was measured, the optimal absorption peaks were recorded and the corresponding absorption coefficient was calculated. Quantitative detection experiments on the four characteristic components were conducted. The volume fraction variation trend of four characteristic components at different PD time were analyzed. And under five different PD quantity, the quantitative relationships among gas production rate, PD time, and PD quantity were studied. PMID:25459612

  5. Fourier transform infrared spectroscopy quantitative analysis of SF6 partial discharge decomposition components

    NASA Astrophysics Data System (ADS)

    Zhang, Xiaoxing; Liu, Heng; Ren, Jiangbo; Li, Jian; Li, Xin

    2015-02-01

    Gas-insulated switchgear (GIS) internal SF6 gas produces specific decomposition components under partial discharge (PD). By detecting these characteristic decomposition components, such information as the type and level of GIS internal insulation deterioration can be obtained effectively, and the status of GIS internal insulation can be evaluated. SF6 was selected as the background gas for Fourier transform infrared spectroscopy (FTIR) detection in this study. SOF2, SO2F2, SO2, and CO were selected as the characteristic decomposition components for system analysis. The standard infrared absorption spectroscopy of the four characteristic components was measured, the optimal absorption peaks were recorded and the corresponding absorption coefficient was calculated. Quantitative detection experiments on the four characteristic components were conducted. The volume fraction variation trend of four characteristic components at different PD time were analyzed. And under five different PD quantity, the quantitative relationships among gas production rate, PD time, and PD quantity were studied.

  6. Serous cutaneous glands in anurans: Fourier transform analysis of the repeating secretory granule substructure

    NASA Astrophysics Data System (ADS)

    Nosi, D.; Delfino, G.; Quercioli, F.

    2013-03-01

    A combined transmission electron microscopy (TEM) and Fourier transform analysis has been performed on the secretory granules storing active peptides/proteins in serous cutaneous glands of n = 12 anuran species. Previous TEM investigation showed that the granules are provided with remarkable repeating substructures based on discrete subunits, arranged into a consistent framework. Furthermore, TEM findings revealed that this recurrent arrangement is acquired during a prolonged post-Golgian (or maturational) processing that affects the secretory product. Maturation leads to a variety of patterns depending on the degree of subunit clustering. This variety of recurrent patterns has been plotted into a range of frequency spectra. Through this quantitative approach, we found that the varying granule substructure can be reduced to a single mechanism of peptide/protein aggregation.

  7. Fourier analysis of parallel inexact Block-Jacobi splitting with transport synthetic acceleration in slab geometry

    SciTech Connect

    Rosa, M.; Warsa, J. S.; Chang, J. H.

    2006-07-01

    A Fourier analysis is conducted for the discrete-ordinates (SN) approximation of the neutron transport problem solved with Richardson iteration (Source Iteration) and Richardson iteration preconditioned with Transport Synthetic Acceleration (TSA), using the Parallel Block-Jacobi (PBJ) algorithm. Both 'traditional' TSA (TTSA) and a 'modified' TSA (MTSA), in which only the scattering in the low order equations is reduced by some non-negative factor {beta} and < 1, are considered. The results for the un-accelerated algorithm show that convergence of the PBJ algorithm can degrade. The PBJ algorithm with TTSA can be effective provided the {beta} parameter is properly tuned for a given scattering ratio c, but is potentially unstable. Compared to TTSA, MTSA is less sensitive to the choice of {beta}, more effective for the same computational effort (c'), and it is unconditionally stable. (authors)

  8. Fabrication and analysis of tall-stepped mirror for use in static Fourier transform infrared spectrometer

    NASA Astrophysics Data System (ADS)

    Chen, Cheng; Liang, Jingqiu; Liang, Zhongzhu; Lü, Jinguang; Qin, Yuxin; Tian, Chao; Wang, Weibiao

    2015-12-01

    A method of "slope splicing" is proposed to build a tall-stepped mirror with high precision in a stepped-mirror-based static Fourier transform infrared spectrometer. The structural parameters were designed, and their errors were analyzed. We present the test results and an analysis of the combined effect of the errors on the recovered spectrum. The spectrum-constructing error of the constructed spectrum, 5.81%, meets the requirements for the system and suitable for realization of a miniaturized spectrometer. We performed experiments with the tall-stepped mirror to obtain the interferogram and spectrum of a silicon carbide light source. Further work is needed to optimize the capability of the system.

  9. Confirmational analysis of beta-agonists by cryotrapping gas chromatography-Fourier transform infrared spectrometry.

    PubMed

    Visser, T; Vredenbregt, M J; de Jong, A P; van Rossum, H J; Stephany, R W; van Ginkel, L A

    1994-12-01

    Cryotrapping gas chromatography-Fourier transform infrared spectrometry has been used for confirmation analysis of the beta-agonists clenbuterol, salbutamol, mabuterol, bromobuterol, cimaterol, cimbuterol and mapenterol in urine and liver samples of veal calves, subsequent to selected ion detection gas chromatography-mass spectrometry. Samples have been analysed as their trimethylsilyl and methylboronate derivatives. Methylboronate derivatives yielded strongly diminished chemical background and interference levels in the infrared chromatograms of standards and samples. The limit of identification for methylboronate derivatives was at the low ppb level in incurred samples. The similarity of analyte and reference spectra, together with the retention time, was found to be a useful criterion for confirmation of unknown compounds. PMID:7879875

  10. Principal component analysis based carrier removal approach for Fourier transform profilometry

    NASA Astrophysics Data System (ADS)

    Feng, Shijie; Chen, Qian; Zuo, Chao

    2015-05-01

    To handle the issue of the nonlinear carrier phase due to the divergent illumination commonly adopted in the fringe projection measurement, we propose a principal component analysis (PCA) based carrier removal method for Fourier transform profilometry. By PCA, the method can decompose the nonlinear carrier phase map into several principal components, where the phase of the carrier can be extracted from the first dominant component acquired. It is effective and requires less human intervention since no data points need to be collected from the reference plane in advance compared with traditional methods. Further, the influence of the lens distortion is considered thus the carrier can be determined more accurately. Our experiment shows the validity of the proposed approach.

  11. Tomographic reconstruction for wide-field adaptive optics systems: Fourier domain analysis and fundamental limitations.

    PubMed

    Neichel, Benoit; Fusco, Thierry; Conan, Jean-Marc

    2009-01-01

    Several wide-field-of-view adaptive optics (WFAO) concepts such as multi-conjugate AO (MCAO), multi-object AO (MOAO), and ground-layer AO (GLAO) are currently being studied for the next generation of Extremely Large Telescopes (ELTs). All these concepts will use atmospheric tomography to reconstruct the turbulent-phase volume. In this paper, we explore different reconstruction algorithms and their fundamental limitations, conducting this analysis in the Fourier domain. This approach allows us to derive simple analytical formulations for the different configurations and brings a comprehensive view of WFAO limitations. We then investigate model and statistical errors and their effect on the phase reconstruction. Finally, we show some examples of different WFAO systems and their expected performance on a 42 m telescope case. PMID:19109619

  12. Single frame method for resolution enhancement of the Fourier fringe analysis method

    NASA Astrophysics Data System (ADS)

    Tavares, Paulo J.; Vaz, Mário A. P.

    2013-11-01

    Fourier Transform Profilometry (FTP) is one of the most popular fringe analysis methods in Optical Metrology for a wealth of applications in Mechanical Engineering, such as shape profilometry or defect detection with shearography or holographic interferometry methods. Gradient range and spatial resolution in the FTP method depend on the size of the filter window in reciprocal space. The authors have previously reported on a method that uses a single crossed fringe pattern for the elimination of the fundamental frequency and enlargement of the carrier window, which is therefore inherently able to cope with dynamic situations. This article describes an improved version of the technique that no longer resources to bit-shifting operations, greatly improving the flexibility of the previously reported technique, whilst retaining its main advantages.

  13. Fast Fourier transform analysis of sounds made while swallowing various foods.

    PubMed

    Taniwaki, Mitsuru; Kohyama, Kaoru

    2012-10-01

    The cervical auscultation method was applied to investigate sounds generated while swallowing various foods with unique physical properties, including liquid (water), semiliquid (yogurt), and solid (konjac jelly). To study the differences among swallowing sounds for various foods, fast Fourier transform (FFT) analysis was applied to signals that were attributed to the flow of a food bolus, which is a swallowable soft mass of chewed food. An FFT program was developed that enabled the calculation of a spectrum for a specified region of time domain swallowing sound signals. The intensity of spectra in the frequency range between 400 and 1000 Hz significantly differed: liquid > semiliquid > solid. The FFT spectrum in this range was suggested to represent the frequency characteristics of the swallowing sounds of various foods. PMID:23039442

  14. 2D wavelet-analysis-based calibration technique for flat-panel imaging detectors: application in cone beam volume CT

    NASA Astrophysics Data System (ADS)

    Tang, Xiangyang; Ning, Ruola; Yu, Rongfeng; Conover, David L.

    1999-05-01

    The application of the newly developed flat panel x-ray imaging detector in cone beam volume CT has attracted increasing interest recently. Due to an imperfect solid state array manufacturing process, however, defective elements, gain non-uniformity and offset image unavoidably exist in all kinds of flat panel x-ray imaging detectors, which will cause severe streak and ring artifacts in a cone beam reconstruction image and severely degrade image quality. A calibration technique, in which the artifacts resulting from the defective elements, gain non-uniformity and offset image can be reduced significantly, is presented in this paper. The detection of defective elements is distinctively based upon two-dimensional (2D) wavelet analysis. Because of its inherent localizability in recognizing singularities or discontinuities, wavelet analysis possesses the capability of detecting defective elements over a rather large x-ray exposure range, e.g., 20% to approximately 60% of the dynamic range of the detector used. Three-dimensional (3D) images of a low-contrast CT phantom have been reconstructed from projection images acquired by a flat panel x-ray imaging detector with and without calibration process applied. The artifacts caused individually by defective elements, gain non-uniformity and offset image have been separated and investigated in detail, and the correlation with each other have also been exposed explicitly. The investigation is enforced by quantitative analysis of the signal to noise ratio (SNR) and the image uniformity of the cone beam reconstruction image. It has been demonstrated that the ring and streak artifacts resulting from the imperfect performance of a flat panel x-ray imaging detector can be reduced dramatically, and then the image qualities of a cone beam reconstruction image, such as contrast resolution and image uniformity are improved significantly. Furthermore, with little modification, the calibration technique presented here is also applicable

  15. Anisotropic multi-resolution analysis in 2D, application to long-range correlations in cloud mm-radar fields

    SciTech Connect

    Davis, A.B.; Clothiaux, E.

    1999-03-01

    Because of Earth`s gravitational field, its atmosphere is strongly anisotropic with respect to the vertical; the effect of the Earth`s rotation on synoptic wind patterns also causes a more subtle form of anisotropy in the horizontal plane. The authors survey various approaches to statistically robust anisotropy from a wavelet perspective and present a new one adapted to strongly non-isotropic fields that are sampled on a rectangular grid with a large aspect ratio. This novel technique uses an anisotropic version of Multi-Resolution Analysis (MRA) in image analysis; the authors form a tensor product of the standard dyadic Haar basis, where the dividing ratio is {lambda}{sub z} = 2, and a nonstandard triadic counterpart, where the dividing ratio is {lambda}{sub x} = 3. The natural support of the field is therefore 2{sup n} pixels (vertically) by 3{sup n} pixels (horizontally) where n is the number of levels in the MRA. The natural triadic basis includes the French top-hat wavelet which resonates with bumps in the field whereas the Haar wavelet responds to ramps or steps. The complete 2D basis has one scaling function and five wavelets. The resulting anisotropic MRA is designed for application to the liquid water content (LWC) field in boundary-layer clouds, as the prevailing wind advects them by a vertically pointing mm-radar system. Spatial correlations are notoriously long-range in cloud structure and the authors use the wavelet coefficients from the new MRA to characterize these correlations in a multifractal analysis scheme. In the present study, the MRA is used (in synthesis mode) to generate fields that mimic cloud structure quite realistically although only a few parameters are used to control the randomness of the LWC`s wavelet coefficients.

  16. Verification of the helioseismic Fourier-Legendre analysis for meridional flow measurements

    NASA Astrophysics Data System (ADS)

    Roth, M.; Doerr, H.-P.; Hartlep, T.

    2016-08-01

    Context. Measuring the Sun's internal meridional flow is one of the key issues of helioseismology. Using the Fourier-Legendre analysis is a technique for addressing this problem. Aims: We validate this technique with the help of artificial helioseismic data. Methods: The analysed data set was obtained by numerically simulating the effect of the meridional flow on the seismic wave field in the full volume of the Sun. In this way, a 51.2-h long time series was generated. The resulting surface velocity field is then analyzed in various settings: Two 360° × 90° halfspheres, two 120° × 60° patches on the front and farside of the Sun (North and South, respectively) and two 120° × 60° patches on the northern and southern frontside only. We compare two possible measurement setups: observations from Earth and from an additional spacecraft on the solar farside, and observations from Earth only, in which case the full information of the global solar oscillation wave field was available. Results: We find that, with decreasing observing area, the accessible depth range decreases: the 360° × 90° view allows us to probe the meridional flow almost to the bottom of the convection zone, while the 120° × 60° view means only the outer layers can be probed. Conclusions: These results confirm the validity of the Fourier-Legendre analysis technique for helioseismology of the meridional flow. Furthermore these flows are of special interest for missions like Solar Orbiter that promises to complement standard helioseismic measurements from the solar nearside with farside observations.

  17. Analysis on oscillating actuator frequency influence of the fluid flow characterization for 2D contractile water jet thruster

    NASA Astrophysics Data System (ADS)

    Shaari, M. F.; Abu Bakar, H.; Nordin, N.; Saw, S. K.; Samad, Z.

    2013-12-01

    Contractile body is an alternative mechanism instead of rotating blade propeller to generate water jet for locomotion. The oscillating motion of the actuator at different frequencies varies the pressure and volume of the pressure chamber in time to draw in and jet out the water at a certain mass flow rate. The aim of this research was to analyze the influence of the actuating frequency of the fluid flow in the pressure chamber of the thruster during this inflation-deflation process. A 70mm × 70mm × 18mm (L × W × T) 2D water jet thruster was fabricated for this purpose. The contractile function was driven using two lateral pneumatic actuators where the fluid flow analysis was focused on the X-Y plane vector. Observation was carried out using a video camera and Matlab image measurement technique to determine the volume of the flowing mass. The result demonstrated that the greater actuating frequency decreases the fluid flow rate and the Reynolds number. This observation shows that the higher frequency would give a higher mass flow rate during water jet generation.

  18. 2D Cross Sectional Analysis and Associated Electrochemistry of Composite Electrodes Containing Dispersed Agglomerates of Nanocrystalline Magnetite, Fe₃O₄.

    PubMed

    Bock, David C; Kirshenbaum, Kevin C; Wang, Jiajun; Zhang, Wei; Wang, Feng; Wang, Jun; Marschilok, Amy C; Takeuchi, Kenneth J; Takeuchi, Esther S

    2015-06-24

    When electroactive nanomaterials are fully incorporated into an electrode structure, characterization of the crystallite sizes, agglomerate sizes, and dispersion of the electroactive materials can lend insight into the complex electrochemistry associated with composite electrodes. In this study, composite magnetite electrodes were sectioned using ultramicrotome techniques, which facilitated the direct observation of crystallites and agglomerates of magnetite (Fe3O4) as well as their dispersal patterns in large representative sections of electrode, via 2D cross sectional analysis by Transmission Electron Microscopy (TEM). Further, the electrochemistry of these electrodes were recorded, and Transmission X-ray Microscopy (TXM) was used to determine the distribution of oxidation states of the reduced magnetite. Unexpectedly, while two crystallite sizes of magnetite were employed in the production of the composite electrodes, the magnetite agglomerate sizes and degrees of dispersion in the two composite electrodes were similar to each other. This observation illustrates the necessity for careful characterization of composite electrodes, in order to understand the effects of crystallite size, agglomerate size, and level of dispersion on electrochemistry. PMID:26024206

  19. 2D-DIGE proteomic analysis of mesenchymal stem cell cultured on the elasticity-tunable hydrogels.

    PubMed

    Kuboki, Thasaneeya; Kantawong, Fahsai; Burchmore, Richard; Dalby, Matthew J; Kidoaki, Satoru

    2012-01-01

    The present study focuses on mechanotransduction in mesenchymal stem cells (MSCs) in response to matrix elasticity. By using photocurable gelatinous gels with tunable stiffness, proteomic profiles of MSCs cultured on tissue culture plastic, soft (3 kPa) and stiff (52 kPa) matrices were deciphered using 2-dimensional differential in-gel analysis (2D-DIGE). The DIGE data, tied to immunofluorescence, indicated abundance and organization changes in the cytoskeletonal proteins as well as differential regulation of important signaling-related proteins, stress-responsing proteins and also proteins involved in collagen synthesis. The major CSK proteins including actin, tubulin and vimentin of the cells cultured on the gels were remarkably changed their expressions. Significant down-regulation of α-tubulin and β-actin can be observed on gel samples in comparison to the rigid tissue culture plates. The expression abundance of vimentin appeared to be highest in the MSCs cultured on hard gels. These results suggested that the substrate stiffness significantly affects expression balances in cytoskeletal proteins of MSCs with some implications to cellular tensegrity. PMID:22971925

  20. Phylogenetic and 2D/3D Analysis of HCV 1a NS4A Gene/Protein in Pakistani Isolates

    PubMed Central

    Hussain, Abrar; Idrees, Muhammad; Asif, Muhammad; Ali, Liaqat; Rasool, Mahmood

    2015-01-01

    Background: The nonstructural protein NS4A of hepatitis C virus is composed of 54 amino acids. This small size protein has vital role in many cellular functions. The most important reported function is being a cofactor of viral enzymes serine protease and helicase. Objectives: The objective of this study was to analyze the phylogenetic variation, its impact in terms of translation and any functional change in protein structure at primary 2D/3D structure using computational tools from Pakistani patients isolates. Materials and Methods: Patient sera infected with Hepatitis C virus, genotype 1A, were obtained from Molecular Diagnostics lab, CEMB, University of the Punjab Lahore by using BD Vacutainer collection tubes (Becton Dickenson). Results: Phylogenetic analysis of the gene revealed that Pakistani 1a HCV strains are in the start of third cluster and there is a difference between inter Pakistani isolates at primary, secondary and tertiary levels. Conclusions: Mutations were present in the central domain of NS4A (amino acids 21 - 34). PMID:26288631

  1. 2D fluid model analysis for the effect of 3D gas flow on a capacitively coupled plasma deposition reactor

    NASA Astrophysics Data System (ADS)

    Kim, Ho Jun; Lee, Hae June

    2016-06-01

    The wide applicability of capacitively coupled plasma (CCP) deposition has increased the interest in developing comprehensive numerical models, but CCP imposes a tremendous computational cost when conducting a transient analysis in a three-dimensional (3D) model which reflects the real geometry of reactors. In particular, the detailed flow features of reactive gases induced by 3D geometric effects need to be considered for the precise calculation of radical distribution of reactive species. Thus, an alternative inclusive method for the numerical simulation of CCP deposition is proposed to simulate a two-dimensional (2D) CCP model based on the 3D gas flow results by simulating flow, temperature, and species fields in a 3D space at first without calculating the plasma chemistry. A numerical study of a cylindrical showerhead-electrode CCP reactor was conducted for particular cases of SiH4/NH3/N2/He gas mixture to deposit a hydrogenated silicon nitride (SiN x H y ) film. The proposed methodology produces numerical results for a 300 mm wafer deposition reactor which agree very well with the deposition rate profile measured experimentally along the wafer radius.

  2. Integral equation analysis and optimization of 2D layered nanolithography masks by complex images Green's function technique in TM polarization.

    PubMed

    Haghtalab, Mohammad; Faraji-Dana, Reza

    2012-05-01

    Analysis and optimization of diffraction effects in nanolithography through multilayered media with a fast and accurate field-theoretical approach is presented. The scattered field through an arbitrary two-dimensional (2D) mask pattern in multilayered media illuminated by a TM-polarized incident wave is determined by using an electric field integral equation formulation. In this formulation the electric field is represented in terms of complex images Green's functions. The method of moments is then employed to solve the resulting integral equation. In this way an accurate and computationally efficient approximate method is achieved. The accuracy of the proposed method is vindicated through comparison with direct numerical integration results. Moreover, the comparison is made between the results obtained by the proposed method and those obtained by the full-wave finite-element method. The ray tracing method is combined with the proposed method to describe the imaging process in the lithography. The simulated annealing algorithm is then employed to solve the inverse problem, i.e., to design an optimized mask pattern to improve the resolution. Two binary mask patterns under normal incident coherent illumination are designed by this method, where it is shown that the subresolution features improve the critical dimension significantly. PMID:22561933

  3. Interaction Between Tropical Convection and its Embedding Environment: An Energetics Analysis of a 2-D Cloud Resolving Simulation

    NASA Technical Reports Server (NTRS)

    Li, Xiaofan; Sui, C.-H.; Lau, K.-M.

    1999-01-01

    The phase relation between the perturbation kinetic energy (K') associated with the tropical convection and the horizontal-mean moist available potential energy (bar-P) associated with environmental conditions is investigated by an energetics analysis of a numerical experiment. This experiment is performed using a 2-D cloud resolving model forced by the TOGA-COARE derived vertical velocity. The imposed upward motion leads to a decrease of bar-P directly through the associated vertical advective cooling, and to an increase of K' directly through cloud related processes, feeding the convection. The maximum K' and its maximum growth rate lags and leads, respectively, the maximum imposed large-scale upward motion by about 1-2 hours, indicating that convection is phase locked with large-scale forcing. The dominant life cycle of the simulated convection is about 9 hours, whereas the time scales of the imposed large-scale forcing are longer than the diurnal cycle. In the convective events, maximum growth of K' leads maximum decay of the perturbation moist available potential energy (P') by about 3 hours through vertical heat transport by perturbation circulation, and perturbation cloud heating. Maximum decay of P' leads maximum decay of bar-P by about one hour through the perturbation radiative, processes, the horizontal-mean cloud heating, and the large-scale vertical advective cooling. Therefore, maximum gain of K' occurs about 4-5 hours before maximum decay of bar-P.

  4. Analysis of pharmaceutical impurities using multi-heartcutting 2D LC coupled with UV-charged aerosol MS detection.

    PubMed

    Zhang, Kelly; Li, Yi; Tsang, Midco; Chetwyn, Nik P

    2013-09-01

    To overcome challenges in HPLC impurity analysis of pharmaceuticals, we developed an automated online multi-heartcutting 2D HPLC system with hyphenated UV-charged aerosol MS detection. The first dimension has a primary column and the second dimension has six orthogonal columns to enhance flexibility and selectivity. The two dimensions were interfaced by a pair of switching valves equipped with six trapping loops that allow multi-heartcutting of peaks of interest in the first dimension and also allow "peak parking." The hyphenated UV-charged aerosol MS detection provides comprehensive detection for compounds with and without UV chromophores, organics, and inorganics. It also provides structural information for impurity identification. A hidden degradation product that co-eluted with the drug main peak was revealed by RP × RP separation and thus enabled the stability-indicating method development. A poorly retained polar component with no UV chromophores was analyzed by RP × hydrophilic interaction liquid chromatography separation with charged aerosol detection. Furthermore, using this system, the structures of low-level impurities separated by a method using nonvolatile phosphate buffer were identified and tracked by MS in the second dimension. PMID:23821312

  5. Spectral analysis of the Chandler wobble: comparison of the discrete Fourier analysis and the maximum entropy method

    NASA Astrophysics Data System (ADS)

    Brzezinski, A.

    2014-12-01

    The methods of spectral analysis are applied to solve the following two problems concerning the free Chandler wobble (CW): 1) to estimate the CW resonance parameters, the period T and the quality factor Q, and 2) to perform the excitation balance of the observed free wobble. It appears, however, that the results depend on the algorithm of spectral analysis applied. Here we compare the following two algorithms which are frequently applied for analysis of the polar motion data, the classical discrete Fourier analysis and the maximum entropy method corresponding to the autoregressive modeling of the input time series. We start from general description of both methods and of their application to the analysis of the Earth orientation observations. Then we compare results of the analysis of the polar motion and the related excitation data.

  6. Application of Elliptic Fourier Analysis to Describe the Lamina Cribrosa Shape with Age and Intraocular Pressure

    PubMed Central

    Sanfilippo, P.G.; Grimm, J.L.; Flanagan, J.G.; Lathrop, K.L.; Sigal, I.A.

    2014-01-01

    The lamina cribrosa (LC) plays an important biomechanical role in the optic nerve head (ONH). We developed a statistical shape model of the LC and tested if the shape varies with age or IOP. The ONHs of 18 donor eyes (47 to 91 years, mean 76 years) fixed at either 5 or 50 mm Hg of IOP were sectioned, stained, and imaged under a microscope. A 3D model of each ONH was reconstructed and the outline of the vertical sagittal section closest to the geometric centre of the LC extracted. The outline shape was described using elliptic Fourier analysis, and principal components analysis (PCA) employed to identify the primary modes of LC shape variation. Linear mixed effect models were used to determine if the shape measurements were associated with age or IOP. The analysis revealed several modes of shape variation: thickness and depth directly (PC1), or inversely (PC2) related, and superior-inferior asymmetry (PC3). Only PC3 was associated with IOP, with higher IOP correlating with greater curvature of the LC superiorly compared to inferiorly. Our analysis enabled a concise and complete characterization of LC shape, revealing variations without defining them a priori. No association between LC shape and age was found for the relatively old population studied. Superior-inferior asymmetry of LC shape was associated with IOP, with more asymmetry at higher IOP. Increased IOP was not associated with LC thickness or depth. PMID:25193035

  7. The Fourier analysis applied to the relationship between (7)Be activity in the Serbian atmosphere and meteorological parameters.

    PubMed

    Rajačić, M M; Todorović, D J; Krneta Nikolić, J D; Janković, M M; Djurdjević, V S

    2016-09-01

    Air sample monitoring in Serbia, Belgrade started in the 1960s, while (7)Be activity in air and total (dry and wet) deposition has been monitored for the last 22 years by the Environment and Radiation Protection Department of the Institute for Nuclear Sciences, Vinca. Using this data collection, the changes of the (7)Be activity in the air and the total (wet and dry) deposition samples, as well as their correlation with meteorological parameters (temperature, pressure, cloudiness, sunshine duration, precipitation and humidity) that affect (7)Be concentration in the atmosphere, were mathematically described using the Fourier analysis. Fourier analysis confirmed the expected; the frequency with the largest intensity in the harmonic spectra of the (7)Be activity corresponds to a period of 1 year, the same as the largest intensity frequency in Fourier series of meteorological parameters. To analyze the quality of the results produced by the Fourier analysis, we compared the measured values of the parameters with the values calculated according to the Fourier series. Absolute deviations between measured and predicted mean monthly values are in range from 0.02 mBq/m(3) to 0.7 mBq/m(3) for (7)Be activity in air, and 0.01 Bq/m(2) and 0.6 Bq/m(2) for (7)Be activity in deposition samples. Relatively good agreement of measured and predicted results offers the possibility of prediction of the (7)Be activity. PMID:27396670

  8. Spectral analysis of the Earth's topographic potential via 2D-DFT: a new data-based degree variance model to degree 90,000

    NASA Astrophysics Data System (ADS)

    Rexer, Moritz; Hirt, Christian

    2015-09-01

    Classical degree variance models (such as Kaula's rule or the Tscherning-Rapp model) often rely on low-resolution gravity data and so are subject to extrapolation when used to describe the decay of the gravity field at short spatial scales. This paper presents a new degree variance model based on the recently published GGMplus near-global land areas 220 m resolution gravity maps (Geophys Res Lett 40(16):4279-4283, 2013). We investigate and use a 2D-DFT (discrete Fourier transform) approach to transform GGMplus gravity grids into degree variances. The method is described in detail and its approximation errors are studied using closed-loop experiments. Focus is placed on tiling, azimuth averaging, and windowing effects in the 2D-DFT method and on analytical fitting of degree variances. Approximation errors of the 2D-DFT procedure on the (spherical harmonic) degree variance are found to be at the 10-20 % level. The importance of the reference surface (sphere, ellipsoid or topography) of the gravity data for correct interpretation of degree variance spectra is highlighted. The effect of the underlying mass arrangement (spherical or ellipsoidal approximation) on the degree variances is found to be crucial at short spatial scales. A rule-of-thumb for transformation of spectra between spherical and ellipsoidal approximation is derived. Application of the 2D-DFT on GGMplus gravity maps yields a new degree variance model to degree 90,000. The model is supported by GRACE, GOCE, EGM2008 and forward-modelled gravity at 3 billion land points over all land areas within the SRTM data coverage and provides gravity signal variances at the surface of the topography. The model yields omission errors of 9 mGal for gravity (1.5 cm for geoid effects) at scales of 10 km, 4 mGal (1 mm) at 2-km scales, and 2 mGal (0.2 mm) at 1-km scales.

  9. The Curvelet Transform in the analysis of 2-D GPR data: Signal enhancement and extraction of orientation-and-scale-dependent information

    NASA Astrophysics Data System (ADS)

    Tzanis, Andreas

    2013-04-01

    processing GPR data is its capability to describe wavefronts. The roots of the CT are traced to the field of Harmonic Analysis, where curvelets were introduced as expansions for asymptotic solutions of wave equations (Smith, 1998; Candès, 1999). In consequence, curvelets can be viewed as primitive and prototype waveforms - they are local in both space and spatial frequency and correspond to a partitioning of the 2D Fourier plane by highly anisotropic elements (for the high frequencies) that obey the parabolic scaling principle, that their width is proportional to the square of their length (Smith, 1998). The GPR data essentially comprise recordings of the amplitudes of transient waves generated and recorded by source and receiver antennae, with each source/receiver pair generating a data trace that is a function of time. An ensemble of traces collected sequentially along a scan line, i.e. a GPR section or B-scan, provides a spatio-temporal sampling of the wavefield which contains different arrivals that correspond to different interactions with wave scatterers (inhomogeneities) in the subsurface. All these arrivals represent wavefronts that are relatively smooth in their longitudinal direction and oscillatory in their transverse direction. The connection between Harmonic Analysis and curvelets has resulted in important nonlinear approximations of functions with intermittent regularity (Candès and Donoho, 2004). Such functions are assumed to be piecewise smooth with singularities, i.e. regions where the derivative diverges. In the subsurface, these singularities correspond to geological inhomogeneities, at the boundaries of which waves reflect. In GPR data, these singularities correspond to wavefronts. Owing to their anisotropic shape, curvelets are well adapted to detect wavefronts at different angles and scales because aligned curvelets of a given scale, locally correlate with wavefronts of the same scale. The CT can also be viewed as a higher dimensional extension of the

  10. Fourier analysis for hydrostatic pressure sensing in a polarization-maintaining photonic crystal fiber

    SciTech Connect

    Childs, Paul; Wong, Allan C. L.; Fu, H. Y.; Liao, Yanbiao; Tam, Hwayaw; Lu Chao; Wai, P. K. A.

    2010-12-20

    .We measured the hydrostatic pressure dependence of the birefringence and birefringent dispersion of a Sagnac interferometric sensor incorporating a length of highly birefringent photonic crystal fiber using Fourier analysis. Sensitivity of both the phase and chirp spectra to hydrostatic pressure is demonstrated. Using this analysis, phase-based measurements showed a good linearity with an effective sensitivity of 9.45nm/MPa and an accuracy of {+-}7.8kPa using wavelength-encoded data and an effective sensitivity of -55.7cm{sup -1}/MPa and an accuracy of {+-}4.4kPa using wavenumber-encoded data. Chirp-based measurements, though nonlinear in response, showed an improvement in accuracy at certain pressure ranges with an accuracy of {+-}5.5kPa for the full range of measured pressures using wavelength-encoded data and dropping to within {+-}2.5kPa in the range of 0.17 to 0.4MPa using wavenumber-encoded data. Improvements of the accuracy demonstrated the usefulness of implementing chirp-based analysis for sensing purposes.

  11. Rainfall/runoff simulation with 2D full shallow water equations: Sensitivity analysis and calibration of infiltration parameters

    NASA Astrophysics Data System (ADS)

    Fernández-Pato, Javier; Caviedes-Voullième, Daniel; García-Navarro, Pilar

    2016-05-01

    One of the most difficult issues in the development of hydrologic models is to find a rigorous source of data and specific parameters to a given problem, on a given location that enable reliable calibration. In this paper, a distributed and physically based model (2D Shallow Water Equations) is used for surface flow and runoff calculations in combination with two infiltration laws (Horton and Green-Ampt) for estimating infiltration in a watershed. This technique offers the capability of assigning a local and time-dependent infiltration rate to each computational cell depending on the available surface water, soil type or vegetation. We investigate how the calibration of parameters is affected by transient distributed Shallow Water model and the complexity of the problem. In the first part of this work, we calibrate the infiltration parameters for both Horton and Green-Ampt models under flat ponded soil conditions. Then, by means of synthetic test cases, we perform a space-distributed sensitivity analysis in order to show that this calibration can be significantly affected by the introduction of topography or rainfall. In the second part, parameter calibration for a real catchment is addressed by comparing the numerical simulations with two different sets of experimental data, corresponding to very different events in terms of the rainfall volume. We show that the initial conditions of the catchment and the rainfall pattern have a special relevance in the quality of the adjustment. Hence, it is shown that the topography of the catchment and the storm characteristics affect the calibration of infiltration parameters.

  12. Comparison and Characterization of Proteomes in the ThreeDomains of Life Using 2D Correlation Analysis

    NASA Astrophysics Data System (ADS)

    Fujishima, K.; Komasa, M.; Kitamura, S.; Tomita, M.; Kanai, A.

    Proteins are a major regulatory component in complex biological systems.Among them, DNA/RNA-binding proteins, the key components of the central dogma of molecular biology, and membrane proteins, which are necessary for both signal transduction and metabolite transport, are suggested to be the most important protein families that arose in the early stage of life. In this study, we computationally analyzed the whole proteome data of six model species to overview the protein diversity in the three domains of life (Bacteria, Archaea and Eukaryota), especially focusing on the above two protein families. To compare the protein distribution among the six model species, we calculated various protein profiles: hydropathy, molecular weight, amino acid composition and periodicity for each protein. We found a domain-specific distribution of the proteome based on 2D correlation analysis of hydropathy and molecular weight. Further, the merged protein distribution of Archaea and other do mains revealed many membrane proteins localized in Bacteria-specific regions with a high ratio of hydropathy and many DNA/RNA-binding proteins localized in Eukaryota-specific regions with a low ratio of hydropathy. Since about half of the proteins encoded in the genome are still functionally unknown, we further conducted Support Vector Machine (SVM)-based functional prediction using amino acid composition (CO score) and periodicity (PD score) as feature vectors to predict the overall number of DNA/RNA-binding proteins and membrane proteins in the proteome. Our estimation indicated that two functional categories occupy approximately 60% to 80% of the proteome, and further, the proportion of the two categories varied among the three domains of life, suggesting that the proteome has gone through different selective pressure during evolution.

  13. Fourier ptychographic microscopy for filtration-based circulating tumor cell enumeration and analysis

    NASA Astrophysics Data System (ADS)

    Williams, Anthony; Chung, Jaebum; Ou, Xiaoze; Zheng, Guoan; Rawal, Siddarth; Ao, Zheng; Datar, Ram; Yang, Changhuei; Cote, Richard

    2014-06-01

    Circulating tumor cells (CTCs) are recognized as a candidate biomarker with strong prognostic and predictive potential in metastatic disease. Filtration-based enrichment technologies have been used for CTC characterization, and our group has previously developed a membrane microfilter device that demonstrates efficacy in model systems and clinical blood samples. However, uneven filtration surfaces make the use of standard microscopic techniques a difficult task, limiting the performance of automated imaging using commercially available technologies. Here, we report the use of Fourier ptychographic microscopy (FPM) to tackle this challenge. Employing this method, we were able to obtain high-resolution color images, including amplitude and phase, of the microfilter samples over large areas. FPM's ability to perform digital refocusing on complex images is particularly useful in this setting as, in contrast to other imaging platforms, we can focus samples on multiple focal planes within the same frame despite surface unevenness. In model systems, FPM demonstrates high image quality, efficiency, and consistency in detection of tumor cells when comparing corresponding microfilter samples to standard microscopy with high correlation (R2=0.99932). Based on these results, we believe that FPM will have important implications for improved, high throughput, filtration-based CTC analysis, and, more generally, image analysis of uneven surfaces.

  14. Advances in Fourier transform infrared spectroscopy of natural glasses: From sample preparation to data analysis

    NASA Astrophysics Data System (ADS)

    von Aulock, F. W.; Kennedy, B. M.; Schipper, C. I.; Castro, J. M.; Martin, D. E.; Oze, C.; Watkins, J. M.; Wallace, P. J.; Puskar, L.; Bégué, F.; Nichols, A. R. L.; Tuffen, H.

    2014-10-01

    Fourier transform infrared spectroscopy (FTIR) is an analytical technique utilized to measure the concentrations of H and C species in volcanic glasses. Water and CO2 are the most abundant volatile species in volcanic systems. Water is present in magmas in higher concentrations than CO2 and is also more soluble at lower pressures, and, therefore it is the dominant volatile forming bubbles during volcanic eruptions. Dissolved water affects both phase equilibria and melt physical properties such as density and viscosity, therefore, water is important for understanding magmatic processes. Additionally, quantitative measurements of different volatile species using FTIR can be achieved at high spatial resolution. Recent developments in analytical equipment such as synchrotron light sources and the development of focal plane array (FPA) detectors allow higher resolution measurements and the acquisition of concentration maps. These new capabilities are being used to characterize spatial gradients (or lack thereof) around bubbles and other textural features, which in turn lead to new insights into the behavior of volcanic feeder systems. Here, practical insights about sample preparation and analysis of the distribution and speciation of volatiles in volcanic glasses using FTIR spectroscopy are discussed. New advances in the field of FTIR analysis produce reliable data at high spatial resolution that can be used to produce datasets on the distribution, dissolution and diffusion of volatiles in volcanic materials.

  15. Discrimination of healthy and osteoarthritic articular cartilage by Fourier transform infrared imaging and Fisher's discriminant analysis.

    PubMed

    Mao, Zhi-Hua; Yin, Jian-Hua; Zhang, Xue-Xi; Wang, Xiao; Xia, Yang

    2016-02-01

    Fourier transform infrared spectroscopic imaging (FTIRI) technique can be used to obtain the quantitative information of content and spatial distribution of principal components in cartilage by combining with chemometrics methods. In this study, FTIRI combining with principal component analysis (PCA) and Fisher's discriminant analysis (FDA) was applied to identify the healthy and osteoarthritic (OA) articular cartilage samples. Ten 10-μm thick sections of canine cartilages were imaged at 6.25μm/pixel in FTIRI. The infrared spectra extracted from the FTIR images were imported into SPSS software for PCA and FDA. Based on the PCA result of 2 principal components, the healthy and OA cartilage samples were effectively discriminated by the FDA with high accuracy of 94% for the initial samples (training set) and cross validation, as well as 86.67% for the prediction group. The study showed that cartilage degeneration became gradually weak with the increase of the depth. FTIRI combined with chemometrics may become an effective method for distinguishing healthy and OA cartilages in future. PMID:26977354

  16. Analysis of Resistant Starches in Rat Cecal Contents Using Fourier Transform Infrared Photoacoustic Spectroscopy

    SciTech Connect

    Anderson, Timothy J.; Ai, Yongfeng; Jones, Roger W.; Houk, Robert S.; Jane, Jay-lin; Zhao, Yinsheng; Birt, Diane F.; McClelland, John F.

    2013-01-29

    Fourier transform infrared photoacoustic spectroscopy (FTIR-PAS) qualitatively and quantitatively measured resistant starch (RS) in rat cecal contents. Fisher 344 rats were fed diets of 55% (w/w, dry basis) starch for 8 weeks. Cecal contents were collected from sacrificed rats. A corn starch control was compared against three RS diets. The RS diets were high-amylose corn starch (HA7), HA7 chemically modified with octenyl succinic anhydride, and stearic-acid-complexed HA7 starch. To calibrate the FTIR-PAS analysis, samples from each diet were analyzed using an enzymatic assay. A partial least-squares cross-validation plot generated from the enzymatic assay and FTIR-PAS spectral results for starch fit the ideal curve with a R2 of 0.997. A principal component analysis plot of components 1 and 2 showed that spectra from diets clustered significantly from each other. This study clearly showed that FTIR-PAS can accurately quantify starch content and identify the form of starch in complex matrices.

  17. Analysis of all-optically tunable functionalities in subwavelength periodic structures by the Fourier modal method

    NASA Astrophysics Data System (ADS)

    Bej, Subhajit; Tervo, Jani; Francés, Jorge; Svirko, Yuri P.; Turunen, Jari

    2016-05-01

    We propose the nonlinear Fourier Modal Method (FMM) [J. Opt. Soc. Am. B 31, 2371 (2014)] as a convenient and versatile numerical tool for the design and analysis of grating based next generation all-optical devices. Here, we include several numerical examples where the FMM is used to simulate all-optically tunable functionalities in sub-wavelength periodic structures. At first, we numerically investigate a 1-D periodic nonlinear binary grating with amorphous TiO2. We plot the diffraction efficiency in the transmitted orders against the structure depth for normally incident plane wave. Change in diffraction efficiencies for different incident field amplitudes are evident from the plots. We verify the accuracy of our implementation by comparing our results with the results obtained with the nonlinear Split Field-Finite Difference Time Domain (SF-FDTD) method. Next we repeat the same experiment with vertically standing amorphous Titanium dioxide (TiO2) nanowire arrays grown on top of quartz which are periodic in two mutually perpendicular directions and examine the efficiencies in the direct transmitted light for different incident field amplitudes. Our third example includes analysis of a form birefringent linear grating with Kerr medium. With FMM we demonstrate that the birefringence of such a structure can be tuned by all-optical means. As a final example, we design a narrow band Guided Mode Resonance Filter (GMRF). Numerical experiments based on the nonlinear FMM reveal that the spectral tunability of such a filter can be obtained by all-optical means.

  18. Fourier ptychographic microscopy for filtration-based circulating tumor cell enumeration and analysis

    PubMed Central

    Williams, Anthony; Chung, Jaebum; Ou, Xiaoze; Zheng, Guoan; Rawal, Siddarth; Ao, Zheng; Datar, Ram; Yang, Changhuei; Cote, Richard

    2014-01-01

    Abstract. Circulating tumor cells (CTCs) are recognized as a candidate biomarker with strong prognostic and predictive potential in metastatic disease. Filtration-based enrichment technologies have been used for CTC characterization, and our group has previously developed a membrane microfilter device that demonstrates efficacy in model systems and clinical blood samples. However, uneven filtration surfaces make the use of standard microscopic techniques a difficult task, limiting the performance of automated imaging using commercially available technologies. Here, we report the use of Fourier ptychographic microscopy (FPM) to tackle this challenge. Employing this method, we were able to obtain high-resolution color images, including amplitude and phase, of the microfilter samples over large areas. FPM’s ability to perform digital refocusing on complex images is particularly useful in this setting as, in contrast to other imaging platforms, we can focus samples on multiple focal planes within the same frame despite surface unevenness. In model systems, FPM demonstrates high image quality, efficiency, and consistency in detection of tumor cells when comparing corresponding microfilter samples to standard microscopy with high correlation (R2=0.99932). Based on these results, we believe that FPM will have important implications for improved, high throughput, filtration-based CTC analysis, and, more generally, image analysis of uneven surfaces. PMID:24949708

  19. Preliminary analysis of the Baranof Fan system, Gulf of Alaska, based on 2D seismic reflection and multibeam bathymetry data

    NASA Astrophysics Data System (ADS)

    LeVoir, M. A.; Gulick, S. P.; Reece, R.; Barth, G. A.; Childs, J. R.; Everson, E. D.; Hart, P. E.; Johnson, K. M.; Lester, W. R.; Sliter, R. W.

    2011-12-01

    The Baranof Fan is a large marine sedimentary system in the eastern Gulf of Alaska, straddling the border between the U.S. and Canada. The volume of the Fan is estimated to be > 200,000 km3. Little is known about the depositional timing, the tectonic and morphologic processes influencing its development, or the role of channel aggradation and avulsion in its progression. Both tectonic and climatic transitions likely influenced the formation and evolution of the Fan, with events including the onset of northern hemisphere glaciation, the Mid-Pleistocene transition, the transport of the Yakutat Terrane along the southeast Alaskan margin, and the uplift of the Coast Mountains. 2D seismic reflection and multibeam bathymetry data were collected in the Gulf of Alaska in June 2011 aboard the R/V Marcus G. Langseth as a part of the U.S. Extended Continental Shelf (ECS) program assessing potential opportunities under the United Nations Law of the Sea Convention. The purpose of the 2011 survey was to determine sediment thickness, velocity structure, stratigraphic architecture, and crustal structure on of the Gulf of Alaska seafloor in support of U.S. continental shelf maritime zone definition. The surveyed geologic features include the Surveyor and Baranof sedimentary systems, which control active sediment distribution in the Gulf of Alaska. Preliminary analysis of these data show four distinct buried channels throughout the mid to distal Baranof Fan, ranging in width from 5 - 9 km, which may have evolved into modern surface channels (ranging in width from 2 - 7 km) visible in both the seismic data and multibeam bathymetry. The location and trajectory of these buried channels, however, appears distinct from the modern Horizon and Mukluk Channels; the buried channels may have avulsed into the modern channel systems, or could possibly be older and now abandoned branches instrumental in building the westward part of the Fan. All of the imaged channels appear to be depositional

  20. Group analysis of the Fourier transform of the spatially homogeneous and isotropic Boltzmann equation with a source term

    NASA Astrophysics Data System (ADS)

    Suriyawichitseranee, A.; Grigoriev, Yu. N.; Meleshko, S. V.

    2015-03-01

    The paper is devoted to group analysis of the spatially homogeneous and isotropic Boltzmann equation with a source term. In fact, the Fourier transform of the Boltzmann equation with respect to the molecular velocity variable is considered. Using a particular class of solutions, the determining equation for the admitted Lie group is reduced to a partial differential equation for the source function. The latter equation is analyzed by an algebraic method. A complete group classification of the Fourier transform of the Boltzmann equation is given. All invariant solutions of this equation are also presented in the paper.

  1. Application of group analysis to the spatially homogeneous and isotropic Boltzmann equation with source using its Fourier image

    NASA Astrophysics Data System (ADS)

    Grigoriev, Yurii N.; Meleshko, Sergey V.; Suriyawichitseranee, Amornrat

    2015-06-01

    Group analysis of the spatially homogeneous and molecular energy dependent Boltzmann equations with source term is carried out. The Fourier transform of the Boltzmann equation with respect to the molecular velocity variable is considered. The correspondent determining equation of the admitted Lie group is reduced to a partial differential equation for the admitted source. The latter equation is analyzed by an algebraic method. A complete group classification of the Fourier transform of the Boltzmann equation with respect to a source function is given. The representation of invariant solutions and corresponding reduced equations for all obtained source functions are also presented.

  2. Whole genome association mapping of grain shape variation among Oryza sativa L. germplasms based on elliptic Fourier analysis

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Although grain shape is an important cereal breeding target, it has been evaluated using simple measurements, e.g. the length : width ratio. We used elliptic Fourier analysis to evaluate grain shape variation and conducted whole genome association mapping of grain shape using a germplasm collectio...

  3. Compositional analysis of metal chelating materials using near-field photothermal Fourier transform infrared microspectroscopy.

    PubMed

    Moffat, Jonathan G; Mayes, Andrew G; Belton, Peter S; Craig, Duncan Q M; Reading, Mike

    2010-01-01

    Photothermal-Fourier transform-infrared (PT-FT-IR) microspectroscopy employs a thermal probe mounted in a scanning probe microscope (SPM). By placement of the tip of the probe on the surface of a solid sample, it can obtain localized IR spectra of a wide range of samples. A second mode of analysis is also available; a sample can be taken from the selected location using a technique called thermally assisted nanosampling (TAN), then a spectrum can be obtained of the nanosample while the probe is remote from the surface. We report a novel method of local compositional analysis that combines both of these types of measurement; a reagent is attached to the tip using TAN, then the reagent is placed in contact with analyte. IR spectroscopy can then be used to analyze any interaction between the reagent and surface it is placed in contact with. All of these modes of analysis were illustrated using a metal chelating agent. In the surface mode, changes to a solid bead of a chelating resin were measured using standard PT-FT-IR. In the nanosampling mode of analysis, a particle of a chelating polymer was attached to the tip of the probe using TAN and this was placed in contact with a concentrated calcium solution. Strong spectral changes were observed that mirrored those found when exposing the surface bound chelating resin bead to a solution of the same ion. A semiquantitative simulation of the PT spectrum for a chelating resin bead was achieved using a thermal diffusion model derived from photoacoustic spectroscopy indicating that semiquantitative or quantitative measurements will be possible in such a system. PMID:19957959

  4. New Multispectrum Fitting Software Used at DLR for Analysis of Laboratory Fourier-Transform Molecular Spectra

    NASA Astrophysics Data System (ADS)

    Loos, Joep; Birk, Manfred; Wagner, Georg

    2014-06-01

    A new fitting tool written in IDL for analysis of single or multiple molecular absorption spectra recorded with a Fourier-transform spectrometer will be presented. The software utilizes a microwindow-based line-by-line approach and its capabilities include the choice of numerous different line-shape models, from a simple Voigt to more sophisticated models including e.g. speed-dependence, Dicke narrowing or Rosenkranz line mixing. A comfortable interactive mode as well as a fully automatic mode have been implemented including various quality assessment procedures like the monitoring of correlation coefficients or the supply of useful information e.g. needed for file cuts (single spectrum residuals). Two application examples will be given as illustration of the software's capabilities. First, the results of a speed-dependent analysis of room temperature water vapor spectra in the 1250-1750 cm-1 range are compared to the original results obtained by an analysis based on single spectra fits applying the Voigt procedure. The results of the new approach show significantly reduced residuals and systematically larger broadening parameters. The so far published Voigt broadening parameters are effective parameters being systematically too small since they compensate narrowing. Usually effective Voigt parameters are retrieved from non-opaque lines and should only be used when modelling non-opaque lines. Second, the results of an analysis of air broadened nitrous oxide spectra in the ν3 rovibrational band utilizing the pCqSDHC model1 including first order line mixing will be presented. Speed dependence of the broadening parameter as well as line mixing have to be considered in order to represent the spectral features down to the 0.1% level.

  5. Interferogram conditioning for improved Fourier analysis and application to X-ray phase imaging by grating interferometry.

    PubMed

    Montaux-Lambert, Antoine; Mercère, Pascal; Primot, Jérôme

    2015-11-01

    An interferogram conditioning procedure, for subsequent phase retrieval by Fourier demodulation, is presented here as a fast iterative approach aiming at fulfilling the classical boundary conditions imposed by Fourier transform techniques. Interference fringe patterns with typical edge discontinuities were simulated in order to reveal the edge artifacts that classically appear in traditional Fourier analysis, and were consecutively used to demonstrate the correction efficiency of the proposed conditioning technique. Optimization of the algorithm parameters is also presented and discussed. Finally, the procedure was applied to grating-based interferometric measurements performed in the hard X-ray regime. The proposed algorithm enables nearly edge-artifact-free retrieval of the phase derivatives. A similar enhancement of the retrieved absorption and fringe visibility images is also achieved. PMID:26561119

  6. 2D Hydrodynamic Based Logic Modeling Tool for River Restoration Decision Analysis: A Quantitative Approach to Project Prioritization

    NASA Astrophysics Data System (ADS)

    Bandrowski, D.; Lai, Y.; Bradley, N.; Gaeuman, D. A.; Murauskas, J.; Som, N. A.; Martin, A.; Goodman, D.; Alvarez, J.

    2014-12-01

    In the field of river restoration sciences there is a growing need for analytical modeling tools and quantitative processes to help identify and prioritize project sites. 2D hydraulic models have become more common in recent years and with the availability of robust data sets and computing technology, it is now possible to evaluate large river systems at the reach scale. The Trinity River Restoration Program is now analyzing a 40 mile segment of the Trinity River to determine priority and implementation sequencing for its Phase II rehabilitation projects. A comprehensive approach and quantitative tool has recently been developed to analyze this complex river system referred to as: 2D-Hydrodynamic Based Logic Modeling (2D-HBLM). This tool utilizes various hydraulic output parameters combined with biological, ecological, and physical metrics at user-defined spatial scales. These metrics and their associated algorithms are the underpinnings of the 2D-HBLM habitat module used to evaluate geomorphic characteristics, riverine processes, and habitat complexity. The habitat metrics are further integrated into a comprehensive Logic Model framework to perform statistical analyses to assess project prioritization. The Logic Model will analyze various potential project sites by evaluating connectivity using principal component methods. The 2D-HBLM tool will help inform management and decision makers by using a quantitative process to optimize desired response variables with balancing important limiting factors in determining the highest priority locations within the river corridor to implement restoration projects. Effective river restoration prioritization starts with well-crafted goals that identify the biological objectives, address underlying causes of habitat change, and recognizes that social, economic, and land use limiting factors may constrain restoration options (Bechie et. al. 2008). Applying natural resources management actions, like restoration prioritization, is

  7. A BENCHMARKING ANALYSIS FOR FIVE RADIONUCLIDE VADOSE ZONE MODELS (CHAIN, MULTIMED_DP, FECTUZ, HYDRUS, AND CHAIN 2D) IN SOIL SCREENING LEVEL CALCULATIONS

    EPA Science Inventory

    Five radionuclide vadose zone models with different degrees of complexity (CHAIN, MULTIMED_DP, FECTUZ, HYDRUS, and CHAIN 2D) were selected for use in soil screening level (SSL) calculations. A benchmarking analysis between the models was conducted for a radionuclide (99Tc) rele...

  8. ENVIRONMENTAL ANALYSIS BY AB INITIO QUANTUM MECHANICAL COMPUTATION AND GAS CHROMATOGRAPHY/FOURIER TRANSFORM INFRARED SPECTROMETRY.

    EPA Science Inventory

    Computational chemistry, in conjunction with gas chromatography/mass spectrometry/Fourier transform infrared spectrometry (GC/MS/FT-IR), was used to tentatively identify seven tetrachlorobutadiene (TCBD) isomers detected in an environmental sample. Computation of the TCBD infrare...

  9. Analysis of the terrestrial ion foreshock: 2D Full-Particle simulation of a curved supercritical shock

    NASA Astrophysics Data System (ADS)

    Lembege, B.; Savoini, P.; Stienlet, J.

    2013-05-01

    Two distinct ion populations backstreaming into the solar wind have been clearly evidenced by various space missions within the quasi-perpendicular region of the ion foreshock located upstream of the Earth's Bow shock (i.e. for 45° ≤ Theta_Bn ≤ 90°, where Theta_Bn is the angle between the shock normal and the upstream magnetostatic field): (i) field-aligned ion beams (« FAB ») characterized by a gyrotropic distribution, and (ii) gyro-phase bunched ions («GPB »), characterized by a NON gyrotropic distribution. The origin of these backstreaming ions has not been clearly identified and is presently analyzed with the help of 2D PIC simulation of a curved shock, where full curvature effects, time of flight effects and both electrons and ions dynamics are fully described within a self consistent approach. Present simulations evidence that these two populations can be effectively created directly by the shock front without invoking microinstabilities. The analysis of both individual and statistical ion trajectories evidences that: (i) two new parameters, namely the interaction time DT_inter and distance of penetration L_depth into the shock wave, play a key role and allow to discriminate these two populations. "GPB" population is characterized by a very short interaction time (DT_inter = 1 to 2 Tci) in comparison to the "FAB" population (DT_inter = 2 Tci to 10 Tci) which moves back and forth between the upstream edge of the shock front and the overshoot, where tci is the upstream ion gyroperiod. (ii) the importance of the injection angle (i.e. the angle between the normal of the shock front and the gyration velocity when ions reach the shock) to understand how the reflection process takes place. (iii) "FAB" population drifts along the curved shock front scanning a large Theta_Bn range from 90°. (iv) "GPB" population is embedded within the "FAB" population near the shock front which explains the difficulty to identify such a population in the experimental

  10. Portable Fourier Transform Spectroscopy for Analysis of Surface Contamination and Quality Control

    NASA Technical Reports Server (NTRS)

    Pugel, Diane

    2012-01-01

    Progress has been made into adapting and enhancing a commercially available infrared spectrometer for the development of a handheld device for in-field measurements of the chemical composition of various samples of materials. The intent is to duplicate the functionality of a benchtop Fourier transform infrared spectrometer (FTIR) within the compactness of a handheld instrument with significantly improved spectral responsivity. Existing commercial technology, like the deuterated L-alanine triglycine sulfide detectors (DLATGS), is capable of sensitive in-field chemical analysis. This proposed approach compares several subsystem elements of the FTIR inside of the commercial, non-benchtop system to the commercial benchtop systems. These subsystem elements are the detector, the preamplifier and associated electronics of the detector, the interferometer, associated readout parameters, and cooling. This effort will examine these different detector subsystem elements to look for limitations in each. These limitations will be explored collaboratively with the commercial provider, and will be prioritized to meet the deliverable objectives. The tool design will be that of a handheld gun containing the IR filament source and associated optics. It will operate in a point-and-shoot manner, pointing the source and optics at the sample under test and capturing the reflected response of the material in the same handheld gun. Data will be captured via the gun and ported to a laptop.

  11. Fourier Analysis Method for Analyzing Highly Congested Mass Spectra of Ion Populations with Repeated Subunits.

    PubMed

    Cleary, Sean P; Thompson, Avery M; Prell, James S

    2016-06-21

    Highly heterogeneous samples that are difficult to resolve chromatographically arise in many contexts, including hetero-oligomeric protein assemblies, chaperone-target and protein-lipid assemblies, and long-chain polymers. Native mass spectrometry has emerged as a powerful tool to probe the stoichiometry and structure of biomolecular ion complexes, including megadalton-sized assemblies and assemblies with dozens of subunits. However, mass spectra of these ions are often highly congested, obfuscating determination of charge state, total mass, or subunit mass with conventional analysis methods. Here, we present a fast Fourier transform-based algorithm that can be used to deconvolve highly congested mass spectra for heterogeneous ion populations with repeated subunits. The method is parameter-free and requires no initial guesses of charge states, total mass, or subunit mass. To demonstrate a range of applications, the method is applied to ubiquitin with multiple adductions of sodium and potassium, single and mixed polymers, and self-assembled native protein-lipid complexes (Nanodiscs). The algorithm facilitates identification of the charge states, subunit mass, and charge-state specific total mass distribution present in the ion population. Results from application of the algorithm to these analytes include the first reported mass spectra and lipid stoichiometries of intact Nanodiscs containing lipid-raft associated sphingomyelin. Advantages to using this method with ion assemblies that have undergone minimal gas-phase collisional "clean-up" to retain native-like stoichiometries are discussed. PMID:27213759

  12. Periodicity analysis of galactic cosmic rays using Fourier, Hilbert, and higher-order spectral methods

    NASA Astrophysics Data System (ADS)

    Vipindas, V.; Gopinath, Sumesh; Girish, T. E.

    2016-04-01

    Galactic cosmic rays (GCRs) that traverse the heliosphere, in the energy range from several 100 MeV to a few GeV, are subjected to heliospheric modulation. GCRs interact with varying fields of the heliosphere to produce fluctuations in cosmic-ray intensity with variations in solar activity. The effects of modulation are continuously measured by the well-established world-wide neutron monitor network. Solar activity indices and cosmic-ray neutron monitor rates (at different cut-off rigidities) have been used to compare Fourier, Hilbert, and higher-order spectral (bispectral) features of GCR intensity variations at six stations for a period of nearly 50 years. The present study reveals that GCRs exhibit a number of short- and long-term periodicities that vary between 9 days and 22 years. The bispectral analysis shows the characteristic features of nonlinear coupling and complex phase relationships between various harmonics present in GCRs and solar activity proxies. We also offer possible explanations for the observed periodicities with the help of the previous findings.

  13. Preparation of Residual Gravity Maps for the Southern Cascade Mountains, Washington Using Fourier Analysis

    SciTech Connect

    Dishberger, Debra McLean

    1983-04-01

    This report represents a continuation of gravity work in the Cascade Mountains of Washington supported by the Division of Geology and Earth Resources since 1974. The purpose of this research has been collection of baseline gravity data for use in geothermal resource evaluation. Results of the Division's gravity studies to date are given in Danes and Phillips (1983a, 1983b). One of the problems encountered when analyzing gravity data is distinguishing between those parts of the data that represent geologic structures of interest, and those that do not. In many cases, the features of interest are relatively small, near-surface features, such as those sought in mineral, petroleum, or geothermal exploration. Gravity anomalies caused by such structures may be distorted or masked by anomalies caused by larger, deeper geologic structures. Gravity anomalies caused by relatively shallow, small geologic structures are termed residual anomalies. Those due to broad, deep-seated features can be described as regional anomalies. The purpose of this report is to describe a Fourier analysis method for separating residual and regional gravity anomalies from a complete Bouguer gravity anomaly field. The technique has been applied to gravity data from the Southern Cascade Mountains, Washington. Residual gravity anomaly maps at a scale of 1:250,000 are presented for various regional wavelength filters, and a power spectrum of the frequency components in the South Cascade gravity data is displayed. No attempt is made to interpret the results of this study in terms of geologic structures.

  14. Spectroscopic analysis of bladder cancer tissues using Fourier transform infrared spectroscopy

    NASA Astrophysics Data System (ADS)

    Al-Muslet, Nafie A.; Ali, Essam E.

    2012-03-01

    Bladder cancer is one of the most common cancers in Africa. It takes several days to reach a diagnosis using histological examinations of specimens obtained by endoscope, which increases the medical expense. Recently, spectroscopic analysis of bladder cancer tissues has received considerable attention as a diagnosis technique due to its sensitivity to biochemical variations in the samples. This study investigated the use of Fourier transform infrared (FTIR) spectroscopy to analyze a number of bladder cancer tissues. Twenty-two samples were collected from 11 patients diagnosed with bladder cancer from different hospitals without any pretreatment. From each patient two samples were collected, one normal and another cancerous. FTIR spectrometer was used to differentiate between normal and cancerous bladder tissues via changes in spectra of these samples. The investigations detected obvious changes in the bands of proteins (1650, 1550 cm-1), lipids (2925, 2850 cm-1), and nucleic acid (1080, 1236 cm-1). The results show that FTIR spectroscopy is promising as a rapid, accurate, nondestructive, and easy to use alternative method for identification and diagnosis of bladder cancer tissues.

  15. Fourier-transform method of data compression and temporal fringe pattern analysis

    SciTech Connect

    Tuck Wah Ng; Kar Tien Ang

    2005-11-20

    Temporal fringe pattern analysis is invaluable in studies of transient phenomena but necessitates large data storage for two essential sets of data, i.e., fringe pattern intensity and deformation phase. We describe a compression scheme based on the Fourier-transform method for temporal fringe data storage that permits retrieval of both the intensity and the deformation phase. When the scheme was used with simulated temporal wavefront interferometry intensity fringe patterns, a high compression ratio of 10.77 was achieved, with a significant useful data ratio of 0.859. The average root-mean-square error in phase value restored was a low 0.0015 rad. With simulated temporal speckle interferometry intensity fringe patterns, the important paremeters varied with the modulation cutoff value applied. For a zero modulation cutoff value, the ratio of data points and the compression ratio values obtained were roughly the same as in wavelength interferometry, albeit the average root-mean-square error in the phase value restored was far higher. By increasing the modulation cutoff value we attained significant reduction and increase in the ratio of data points and the compression ratio, respectively, whereas the average root-mean-square error in the restored phase values was reduced only slightly.

  16. Analysis of pork adulteration in beef meatball using Fourier transform infrared (FTIR) spectroscopy.

    PubMed

    Rohman, A; Sismindari; Erwanto, Y; Che Man, Yaakob B

    2011-05-01

    Meatball is one of the favorite foods in Indonesia. The adulteration of pork in beef meatball is frequently occurring. This study was aimed to develop a fast and non destructive technique for the detection and quantification of pork in beef meatball using Fourier transform infrared (FTIR) spectroscopy and partial least square (PLS) calibration. The spectral bands associated with pork fat (PF), beef fat (BF), and their mixtures in meatball formulation were scanned, interpreted, and identified by relating them to those spectroscopically representative to pure PF and BF. For quantitative analysis, PLS regression was used to develop a calibration model at the selected fingerprint regions of 1200-1000 cm(-1). The equation obtained for the relationship between actual PF value and FTIR predicted values in PLS calibration model was y = 0.999x + 0.004, with coefficient of determination (R(2)) and root mean square error of calibration are 0.999 and 0.442, respectively. The PLS calibration model was subsequently used for the prediction of independent samples using laboratory made meatball samples containing the mixtures of BF and PF. Using 4 principal components, root mean square error of prediction is 0.742. The results showed that FTIR spectroscopy can be used for the detection and quantification of pork in beef meatball formulation for Halal verification purposes. PMID:21227596

  17. Fourier analysis of electrical impedance variations in urinary bladder during changes of intravesical pressure

    NASA Astrophysics Data System (ADS)

    Sivkov, A. V.; Mudraya, I. S.; Revenko, S. V.; Ibragimov, A. R.; Nesterov, A. V.; Gavrilov, I. Yu; Kirpatovsky, V. I.; Stranadko, M. V.

    2010-04-01

    Original hardware and software system was used to record and analyze the variations of electrical impedance of the urinary bladder in narcotized rats (n=7) at rest, during instillation of physiological saline into the bladder resulted in elevation of intravesical pressure, and during subsequent urination accompanied by intravesical pressure release. Fourier analysis of impedance variations revealed three periodic components with the frequencies of heartbeat, respiration, and the Mayer wave (~0.1 Hz). In resting bladder, the amplitude of Mayer and respiratory spectrum peaks were high, and they increased to a different extent during physiological elevation of intravesical pressure, while a small cardiac peak did not changed significantly and tended to decrease at high intravesical pressure. Urination released intravesical pressure and restored all the peaks to the resting level. It is hypothesized that Mayer and respiratory bioimpedance oscillations of urinary bladder are neural in origin, while the cardiac peak is mainly determined by hydrodynamic arterial pulsations. The novel method can assess vesical circulation and its neural control at various phases of bladder activity.

  18. Fast Fourier transformation analysis of kindling-induced afterdischarge in the rabbit hippocampus.

    PubMed

    Tsuchiya, Komei; Kogure, Shinichi

    2011-06-01

    Kindling is a widely used animal model of intractable temporal lobe epilepsy. In the present study, we performed fast Fourier transformation (FFT) analysis of kindling-induced afterdischarge (AD) in the rabbit hippocampus. Ten adult rabbits were used. Kindling stimulation to the right hippocampus was delivered as a train of biphasic pulses (1 ms duration each) of 50 Hz for 1s, with suprathreshold intensity for AD. Motor responses were classified into five stages according to the conventional criteria. Of 10 animals, five developed stage 5 convulsions with a mean of 21 stimulations (kindled (K) group), while the remaining five animals did not (incomplete kindling (IK) group). We standardized each ratio of power spectral density of lower frequency band component (LFB: 0-9 Hz) and the higher frequency band (HFB: 12-30 Hz) in the initial stage as 1.0. The IK group exhibited small decrements (0.99 and 0.94 times) in LFB and HFB components at the final stage. In contrast, the K group exhibited a significantly (p<0.05) large decrement (0.49 times) in the LFB component and a very large increment (4.45 times) of HFB component at the final stage. Correlation analyses were performed between alteration of power spectral density ratio of the HFB component and AD duration, interictal discharge frequency, and behavioral stage during kindling progression. Fairly strong positive correlations were found in all cases in the K group. FFT analysis of kindling-induced AD demonstrated an important role of the HFB component: enhancement of the HFB component is associated with kindled stage, while decrement of it is associated with incomplete kindling stage. These findings suggest that FFT analysis of stimulus-induced and spontaneous seizure discharges is useful for examination of the progression of epileptic disorders. PMID:21498048

  19. Discrimination among populations of sockeye salmon fry with Fourier analysis of otolith banding patterns formed during incubation

    USGS Publications Warehouse

    Finn, J.E.; Burger, C.V.; Holland-Bartels, L.

    1997-01-01

    We used otolith banding patterns formed during incubation to discriminate among hatchery- and wild-incubated fry of sockeye salmon Oncorhynchus nerka from Tustumena Lake, Alaska. Fourier analysis of otolith luminance profiles was used to describe banding patterns: the amplitudes of individual Fourier harmonics were discriminant variables. Correct classification of otoliths to either hatchery or wild origin was 83.1% (cross-validation) and 72.7% (test data) with the use of quadratic discriminant function analysts on 10 Fourier amplitudes. Overall classification rates among the six test groups (one hatchery and five wild groups) were 46.5% (cross-validation) and 39.3% (test data) with the use of linear discriminant function analysis on 16 Fourier amplitudes. Although classification rates for wild-incubated fry from any one site never exceeded 67% (cross-validation) or 60% (test data), location-specific information was evident for all groups because the probability of classifying an individual to its true incubation location was significantly greater than chance. Results indicate phenotypic differences in otolith microstructure among incubation sites separated by less than 10 km. Analysis of otolith luminance profiles is a potentially useful technique for discriminating among and between various populations of hatchery and wild fish.

  20. Fourier Analysis and Structure Determination--Part III: X-ray Crystal Structure Analysis.

    ERIC Educational Resources Information Center

    Chesick, John P.

    1989-01-01

    Discussed is single crystal X-ray crystal structure analysis. A common link between the NMR imaging and the traditional X-ray crystal structure analysis is reported. Claims that comparisons aid in the understanding of both techniques. (MVL)

  1. Analysis of EEG signals regularity in adults during video game play in 2D and 3D.

    PubMed

    Khairuddin, Hamizah R; Malik, Aamir S; Mumtaz, Wajid; Kamel, Nidal; Xia, Likun

    2013-01-01

    Video games have long been part of the entertainment industry. Nonetheless, it is not well known how video games can affect us with the advancement of 3D technology. The purpose of this study is to investigate the EEG signals regularity when playing video games in 2D and 3D modes. A total of 29 healthy subjects (24 male, 5 female) with mean age of 21.79 (1.63) years participated. Subjects were asked to play a car racing video game in three different modes (2D, 3D passive and 3D active). In 3D passive mode, subjects needed to wear a passive polarized glasses (cinema type) while for 3D active, an active shutter glasses was used. Scalp EEG data was recorded during game play using 19-channel EEG machine and linked ear was used as reference. After data were pre-processed, the signal irregularity for all conditions was computed. Two parameters were used to measure signal complexity for time series data: i) Hjorth-Complexity and ii) Composite Permutation Entropy Index (CPEI). Based on these two parameters, our results showed that the complexity level increased from eyes closed to eyes open condition; and further increased in the case of 3D as compared to 2D game play. PMID:24110125

  2. Resolution issues in the analysis of radar signals via Fourier approaches

    NASA Astrophysics Data System (ADS)

    Flores, Benjamin C.; Ochoa, Hector A.; Thomas, Gabriel

    2004-08-01

    Classical work in the field of high-resolution radar often assumes that an echo signal is made of a number of components that can be decomposed via Fourier analysis. Adjacent components are said to be resolved in the frequency domain if the intensity between them drops at least 3 decibels. This working definition is an extension of Lord Rayleigh's criterion for optical resolution. The problem with this approach is that whereas Rayleigh's criterion assumes signal incoherence, thus allowing for the addition of power components, a high-resolution radar signal is often the coherent sum of sinusoids, which implies voltage addition. The purpose of this paper is to discuss the consequences of using Rayleigh's criterion in the analysis of radar signals. Specifically, computer simulations using a complex signal are analyzed via the periodogram as the relative phase between the two components of the signal is allowed to change. The net effect introduced by this phase variation is to reduce or increase the spacing and intensity between two adjacent spectral peaks. These changes are due to constructive or destructive interference of spectral cross terms that cannot be ignored when attempting to resolve frequency components from one another. For instance, the simulations show that when using the averaged periodogram, the intensity in-between two adjacent components is above the -3 decibel threshold for a phase range of 1.2π radians, although the standard resolution criterion of c/2β is satisfied. Similar results are obtained when using a number of windows that are known to control sidelobe levels. Thus, the use of Rayleigh's criterion to define the resolution of a high-resolution radar system is technically inconsistent and undermines our ability to perform quantitative comparisons of target profiles, Doppler profiles and range-Doppler images. In this light, the authors promote the adoption of alternative criteria for judging resolution gains based on the norm of the signal

  3. Headspace Analysis of Volatile Compounds Using Segemented Chirped-Pulse Fourier Transform Mm-Wave Spectroscopy

    NASA Astrophysics Data System (ADS)

    Harris, Brent; Steber, Amanda; Pate, Brooks

    2014-06-01

    A chirped-pulse Fourier transform mm-wave spectrometer has been tested in analytical chemistry applications of headspace analysis of volatile species. A solid-state mm-wave light source (260-290 GHz) provides 30-50 mW of power. This power is sufficient to achieve optimal excitation of individual transitions of molecules with dipole moments larger than about 0.1 D. The chirped-pulse spectrometer has near 100% measurement duty cycle using a high-speed digitizer (4 GS/s) with signal accumulation in an FPGA. The combination of the ability to perform optimal pulse excitation and near 100% measurement duty cycle gives a spectrometer that is fully optimized for trace detection. The performance of the instrument is tested using an EPA sample (EPA VOC Mix 6 - Supelco) that contains a set of molecules that are fast eluting on gas chromatographs and, as a result, present analysis challenges to mass spectrometry. The ability to directly analyze the VOC mixture is tested by acquiring the full bandwidth (260-290 GHz) spectrum in a "high dynamic range" measurement mode that minimizes spurious spectrometer responses. The high-resolution of molecular rotational spectroscopy makes it easy to analyze this mixture without the need for chemical separation. The sensitivity of the instrument for individual molecule detection, where a single transition is polarized by the excitation pulse, is also tested. Detection limits in water will be reported. In the case of chloromethane, the detection limit (0.1 microgram/L), matches the sensitivity reported in the EPA measurement protocol (EPA Method 524) for GC/MS.

  4. SU-E-T-77: Comparison of 2D and 3D Gamma Analysis in Patient-Specific QA for Prostate VMAT Plans

    SciTech Connect

    Clemente, F; Perez, C

    2014-06-01

    Purpose: Patient-specific QA procedures for IMRT and VMAT are traditionally performed by comparing TPS calculations with measured single point values and plane dose distributions by means of gamma analysis. New QA devices permit us to calculate 3D dose distributions on patient anatomy as redundant secondary check and reconstruct it from measurements taken with 2D and 3D detector arrays. 3D dose calculations allow us to perform DVH-based comparisons with clinical relevance, as well as 3D gamma analysis. One of these systems (Compass, IBA Dosimetry) combines traditional 2D with new anatomical-based 3D gamma analysis. This work shows the ability of this system by comparing 2D and 3D gamma analysis in pre-treatment QA for several VMAT prostate plans. Methods: Compass is capable of calculating dose as secondary check from DICOM TPS data and reconstructing it from measurements taken by a 2D ion chamber array (MatriXX Evolution, IBA Dosimetry). Both 2D and 3D gamma tests are available to compare calculated and reconstructed dose in Compass with TPS RT Dose. Results: 15 VMAT prostate plans have been measured with Compass. Dose is reconstructed with Compass for these plans. 2D gamma comparisons can be done for any plane from dose matrix. Mean gamma passing rates for isocenter planes (axial, coronal, sagittal) are (99.7±0.2)%, (99.9±0.1)%, (99.9±0.1)% for reconstructed dose planes. 3D mean gamma passing rates are (98.5±1.7)% for PTVs, (99.1±1.5)% for rectum, (100.0±0.0)% for bladder, (99.6±0.7)% for femoral heads and (98.1±4.1)% for penile bulb. Conclusion: Compass is a powerful tool to perform a complete pre-treatment QA analysis, from 2D techniques to 3D DVH-based techniques with clinical relevance. All reported values for VMAT prostate plans are in good agreement with TPS values. This system permits us to ensure the accuracy in the delivery of VMAT treatments completing a full patient-specific QA program.

  5. Numerical study of the effect of normalised window size, sampling frequency, and noise level on short time Fourier transform analysis

    SciTech Connect

    Ota, T. A.

    2013-10-15

    Photonic Doppler velocimetry, also known as heterodyne velocimetry, is a widely used optical technique that requires the analysis of frequency modulated signals. This paper describes an investigation into the errors of short time Fourier transform analysis. The number of variables requiring investigation was reduced by means of an equivalence principle. Error predictions, as the number of cycles, samples per cycle, noise level, and window type were varied, are presented. The results were found to be in good agreement with analytical models.

  6. Numerical study of the effect of normalised window size, sampling frequency, and noise level on short time Fourier transform analysis

    NASA Astrophysics Data System (ADS)

    Ota, T. A.

    2013-10-01

    Photonic Doppler velocimetry, also known as heterodyne velocimetry, is a widely used optical technique that requires the analysis of frequency modulated signals. This paper describes an investigation into the errors of short time Fourier transform analysis. The number of variables requiring investigation was reduced by means of an equivalence principle. Error predictions, as the number of cycles, samples per cycle, noise level, and window type were varied, are presented. The results were found to be in good agreement with analytical models.

  7. User's Guide for MSAP2D: A Program for Unsteady Aerodynamic and Aeroelastic (Flutter and Forced Response) Analysis of Multistage Compressors and Turbines. 1.0

    NASA Technical Reports Server (NTRS)

    Reddy, T. S. R.; Srivastava, R.

    1996-01-01

    This guide describes the input data required for using MSAP2D (Multi Stage Aeroelastic analysis Program - Two Dimensional) computer code. MSAP2D can be used for steady, unsteady aerodynamic, and aeroelastic (flutter and forced response) analysis of bladed disks arranged in multiple blade rows such as those found in compressors, turbines, counter rotating propellers or propfans. The code can also be run for single blade row. MSAP2D code is an extension of the original NPHASE code for multiblade row aerodynamic and aeroelastic analysis. Euler equations are used to obtain aerodynamic forces. The structural dynamic equations are written for a rigid typical section undergoing pitching (torsion) and plunging (bending) motion. The aeroelastic equations are solved in time domain. For single blade row analysis, frequency domain analysis is also provided to obtain unsteady aerodynamic coefficients required in an eigen analysis for flutter. In this manual, sample input and output are provided for a single blade row example, two blade row example with equal and unequal number of blades in the blade rows.

  8. A model for calculating the errors of 2D bulk analysis relative to the true 3D bulk composition of an object, with application to chondrules

    NASA Astrophysics Data System (ADS)

    Hezel, Dominik C.

    2007-09-01

    Certain problems in Geosciences require knowledge of the chemical bulk composition of objects, such as, for example, minerals or lithic clasts. This 3D bulk chemical composition (bcc) is often difficult to obtain, but if the object is prepared as a thin or thick polished section a 2D bcc can be easily determined using, for example, an electron microprobe. The 2D bcc contains an error relative to the true 3D bcc that is unknown. Here I present a computer program that calculates this error, which is represented as the standard deviation of the 2D bcc relative to the real 3D bcc. A requirement for such calculations is an approximate structure of the 3D object. In petrological applications, the known fabrics of rocks facilitate modeling. The size of the standard deviation depends on (1) the modal abundance of the phases, (2) the element concentration differences between phases and (3) the distribution of the phases, i.e. the homogeneity/heterogeneity of the object considered. A newly introduced parameter " τ" is used as a measure of this homogeneity/heterogeneity. Accessory phases, which do not necessarily appear in 2D thin sections, are a second source of error, in particular if they contain high concentrations of specific elements. An abundance of only 1 vol% of an accessory phase may raise the 3D bcc of an element by up to a factor of ˜8. The code can be queried as to whether broad beam, point, line or area analysis technique is best for obtaining 2D bcc. No general conclusion can be deduced, as the error rates of these techniques depend on the specific structure of the object considered. As an example chondrules—rapidly solidified melt droplets of chondritic meteorites—are used. It is demonstrated that 2D bcc may be used to reveal trends in the chemistry of 3D objects.

  9. Sensitivity and specificity of 3-D texture analysis of lung parenchyma is better than 2-D for discrimination of lung pathology in stage 0 COPD

    NASA Astrophysics Data System (ADS)

    Xu, Ye; Sonka, Milan; McLennan, Geoffrey; Guo, Junfeng; Hoffman, Eric

    2005-04-01

    Lung parenchyma evaluation via multidetector-row CT (MDCT), has significantly altered clinical practice in the early detection of lung disease. Our goal is to enhance our texture-based tissue classification ability to differentiate early pathologic processes by extending our 2-D Adaptive Multiple Feature Method (AMFM) to 3-D AMFM. We performed MDCT on 34 human volunteers in five categories: emphysema in severe Chronic Obstructive Pulmonary Disease (COPD) as EC, emphysema in mild COPD (MC), normal appearing lung in COPD (NC), non-smokers with normal lung function (NN), smokers with normal function (NS). We volumetrically excluded the airway and vessel regions, calculated 24 volumetric texture features for each Volume of Interest (VOI); and used Bayesian rules for discrimination. Leave-one-out and half-half methods were used for testing. Sensitivity, specificity and accuracy were calculated. The accuracy of the leave-one-out method for the four-class classification in the form of 3-D/2-D is: EC: 84.9%/70.7%, MC: 89.8%/82.7%; NC: 87.5.0%/49.6%; NN: 100.0%/60.0%. The accuracy of the leave-one-out method for the two-class classification in the form of 3-D/2-D is: NN: 99.3%/71.6%; NS: 99.7%/74.5%. We conclude that 3-D AMFM analysis of the lung parenchyma improves discrimination compared to 2-D analysis of the same images.

  10. Importance of the Correlation between Width and Length in the Shape Analysis of Nanorods: Use of a 2D Size Plot To Probe Such a Correlation.

    PubMed

    Zhao, Zhihua; Zheng, Zhiqin; Roux, Clément; Delmas, Céline; Marty, Jean-Daniel; Kahn, Myrtil L; Mingotaud, Christophe

    2016-08-22

    Analysis of nanoparticle size through a simple 2D plot is proposed in order to extract the correlation between length and width in a collection or a mixture of anisotropic particles. Compared to the usual statistics on the length associated with a second and independent statistical analysis of the width, this simple plot easily points out the various types of nanoparticles and their (an)isotropy. For each class of nano-objects, the relationship between width and length (i.e., the strong or weak correlations between these two parameters) may suggest information concerning the nucleation/growth processes. It allows one to follow the effect on the shape and size distribution of physical or chemical processes such as simple ripening. Various electron microscopy pictures from the literature or from the authors' own syntheses are used as examples to demonstrate the efficiency and simplicity of the proposed 2D plot combined with a multivariate analysis. PMID:27460632

  11. Multiband analysis and synthesis of spectro-temporal modulations of Fourier spectrogram.

    PubMed

    Chi, Tai-Shih; Hsu, Chung-Chien

    2011-05-01

    The two-dimensional spectro-temporal modulation filtering concept of the auditory model [T. Chi, P. Ru, and S. A. Shamma, J. Acoust. Soc. Am. 118(2), 887-906 (2005)] is implemented on the Fourier spectrogram. The Fourier magnitude spectrogram is analyzed in terms of its joint spectro-temporal modulations, which embed the temporal dynamics and spectral structures. Instead of iterative projection methods, the overlap-and-add method is adopted to invert modified Fourier spectrograms back to sounds. The proposed framework not only provides a similar spectro-temporal analytical process for sounds as the auditory model but also produces synthesized sounds with better quality in a timely manner, which makes proposed framework feasible to human speech recognition (HSR) applications as well. PMID:21568374

  12. Fourier transform infrared spectroscopic analysis of sperm chromatin structure and DNA stability.

    PubMed

    Oldenhof, H; Schütze, S; Wolkers, W F; Sieme, H

    2016-05-01

    Sperm chromatin structure and condensation determine accessibility for damage, and hence success of fertilization and development. The aim of this study was to reveal characteristic spectral features coinciding with abnormal sperm chromatin packing (i.e., DNA-protein interactions) and decreased fertility, using Fourier transform infrared spectroscopy. Chromatin structure in spermatozoa obtained from different stallions was investigated. Furthermore, spermatozoa were exposed to oxidative stress, or treated with thiol-oxidizing and disulfide-reducing agents, to alter chromatin structure and packing. Spectroscopic studies were corroborated with flow cytometric analyses using the DNA-intercalating fluorescent dye acridine orange. Decreased fertility of individuals correlated with increased abnormal sperm morphology and decreased stability toward induced DNA damage. Treatment with the disulfide reducing agent dithiothreitol resulted in increased sperm chromatin decondensation and DNA accessibility, similar as found for less mature epididymal spermatozoa. In situ infrared spectroscopic analysis revealed that characteristic bands arising from the DNA backbone (ν1230, ν1086, ν1051 cm(-1) ) changed in response to induced oxidative damage, water removal, and decondensation. This coincided with changes in the amide-I region (intensity at ν1620 vs. ν1640 cm(-1) ) denoting concomitant changes in protein secondary structure. Reduction in protein disulfide bonds resulted in a decreased value of the asymmetric to symmetric phosphate band intensity (ν1230/ν1086 cm(-1) ), suggesting that this band ratio is sensitive for the degree of chromatin condensation. Moreover, when analyzing spermatozoa from different individuals, it was found that the asymmetric/symmetric phosphate band ratio negatively correlated with the percentage of morphologically abnormal spermatozoa. PMID:26916383

  13. Hyperfine structure constants of singly ionized manganese obtained from analysis of Fourier Transform spectra

    NASA Astrophysics Data System (ADS)

    Townley-Smith, Keeley; Nave, Gillian; Imperial College London

    2016-01-01

    There is an on-going project in the Atomic Spectroscopy Group at NIST to obtain comprehensive spectral data for all of the singly ionized iron group elements and acquire more accurate energy levels, wavelengths and hyperfine structure (HFS) constants. The heavy abundance of the iron group elements and their contributions to a wide range of stellar spectra makes them of interest for astrophysical observations.Existing spectroscopic data for Mn are insufficient to model spectra obtained from HgMn stars such as HD 175640. Since manganese has an odd number of nucleons, its spectral lines generally exhibit HFS, a relativistic effect due to interaction between the magnetic moment of the nucleus and the orbiting electrons. If proper treatment of line broadening effects such as HFS is not taken, there is a poor fit of the lines in stellar spectra, leading to an overestimate of the abundance of Mn. The abnormally high abundance of manganese in HgMn stars means both weak and strong transitions are important. Weak lines may not be observed in the laboratory, but HFS constants for them can be derived from stronger transitions that combine with the two levels involved in the weak transition.Holt et al. (1999) measured HFS constants for 56 energy levels using laser spectroscopy. We have analyzed Fourier Transform spectra of a high current Mn/Ni hollow cathode lamp to obtain magnetic dipole A constants levels of Mn II. The A constants of Holt et al. (1999, MNRAS 306, 1007) for the z5P, z7P2, a5P and z5F levels were the starting point for our analysis, from which we derived A constants for 71 energy levels, including 51 previously unstudied levels. Our A constant for the a7S3 ground level differs by 5x10-4 cm-1 from that of Blackwell-Whitehead et al. (2005, ApJS 157, 402) and has a factor of 6 lower uncertainty.

  14. Analysis of aircraft exhausts with Fourier-transform infrared emission spectroscopy.

    PubMed

    Heland, J; Schäfer, K

    1997-07-20

    Because of the worldwide growth in air traffic and its increasing effects on the atmospheric environment, it is necessary to quantify the direct aircraft emissions at all altitudes. In this study Fourier-transform infrared emission spectroscopy as a remote-sensing multi-component-analyzing technique for aircraft exhausts was investigated at ground level with a double pendulum interferometer and a line-by-line computer algorithm that was applied to a multilayer radiative transfer problem. Initial measurements were made to specify the spectral windows for traceable compounds, to test the sensitivity of the system, and to develop calibration and continuum handling procedures. To obtain information about the radial temperature and concentration profiles, we developed an algorithm for the analysis of an axial-symmetric multilayered plume by use of the CO(2) hot band at approximately 2400 cm(-1). Measurements were made with several in-service engines. Effects that were due to engine aging were detected but have to be analyzed systematically in the near future. Validation measurements were carried out with a conventional propane gas burner to compare the results with those obtained with standard measurement equipment. These measurements showed good agreement to within +/-20% for the CO and NO(x) results. The overall accuracy of the system was found to be +/-30%. The detection limits of the system for a typical engine plume (380 degrees C, ? = 50 cm) are below 0.1% for CO(2), ~0.7% for H(2)O, ~20 ppmv (parts per million by volume) for CO, and ~90 ppmv for NO. PMID:18259296

  15. [The influence of oil heat treatment on wood decay resistance by Fourier infrared spectrum analysis].

    PubMed

    Wang, Ya-Mei; Ma, Shu-Ling; Feng, Li-Qun

    2014-03-01

    Wood preservative treatment can improve defects of plantation wood such as easy to corrupt and moth eaten. Among them heat-treatment is not only environmental and no pollution, also can improve the corrosion resistance and dimension stability of wood. In this test Poplar and Mongolian Seoteh Pine was treated by soybean oil as heat-conducting medium, and the heat treatment wood was studied for indoor decay resistance; wood chemical components before and after treatment, the effect of heat treatment on wood decay resistance performance and main mechanism of action were analysed by Fourier infrared spectrometric. Results showed that the mass loss rate of poplar fell from 19.37% to 5% and Mongolian Seoteh Pine's fell from 8.23% to 3.15%, so oil heat treatment can effectively improve the decay resistance. Infrared spectrum analysis shows that the heat treatment made wood's hydrophilic groups such as hydroxyl groups in largely reduced, absorbing capacity decreased and the moisture of wood rotting fungi necessary was reduced; during the heat treatment wood chemical components such as cellulose, hemicellu lose were degraded, and the nutrient source of wood rotting fungi growth necessary was reduced. Wood decay fungi can grow in the wood to discredit wood is because of that wood can provide better living conditions for wood decay fungi, such as nutrients, water, oxygen, and so on. The cellulose and hemicellulose in wood is the main nutrition source of wood decay fungi. So the oil heat-treatment can reduce the cellulose, hemicellulose nutrition source of wood decay fungi so as to improve the decay resistance of wood. PMID:25208386

  16. Electron tomography, three-dimensional Fourier analysis and colour prediction of a three-dimensional amorphous biophotonic nanostructure

    PubMed Central

    Shawkey, Matthew D.; Saranathan, Vinodkumar; Pálsdóttir, Hildur; Crum, John; Ellisman, Mark H.; Auer, Manfred; Prum, Richard O.

    2009-01-01

    Organismal colour can be created by selective absorption of light by pigments or light scattering by photonic nanostructures. Photonic nanostructures may vary in refractive index over one, two or three dimensions and may be periodic over large spatial scales or amorphous with short-range order. Theoretical optical analysis of three-dimensional amorphous nanostructures has been challenging because these structures are difficult to describe accurately from conventional two-dimensional electron microscopy alone. Intermediate voltage electron microscopy (IVEM) with tomographic reconstruction adds three-dimensional data by using a high-power electron beam to penetrate and image sections of material sufficiently thick to contain a significant portion of the structure. Here, we use IVEM tomography to characterize a non-iridescent, three-dimensional biophotonic nanostructure: the spongy medullary layer from eastern bluebird Sialia sialis feather barbs. Tomography and three-dimensional Fourier analysis reveal that it is an amorphous, interconnected bicontinuous matrix that is appropriately ordered at local spatial scales in all three dimensions to coherently scatter light. The predicted reflectance spectra from the three-dimensional Fourier analysis are more precise than those predicted by previous two-dimensional Fourier analysis of transmission electron microscopy sections. These results highlight the usefulness, and obstacles, of tomography in the description and analysis of three-dimensional photonic structures. PMID:19158016

  17. Modeling and analysis of surface potential of single gate fully depleted SOI MOSFET using 2D-Poisson's equation

    NASA Astrophysics Data System (ADS)

    Mani, Prashant; Tyagi, Chandra Shekhar; Srivastav, Nishant

    2016-03-01

    In this paper the analytical solution of the 2D Poisson's equation for single gate Fully Depleted SOI (FDSOI) MOSFET's is derived by using a Green's function solution technique. The surface potential is calculated and the threshold voltage of the device is minimized for the low power consumption. Due to minimization of threshold voltage the short channel effect of device is suppressed and after observation we obtain the device is kink free. The structure and characteristics of SingleGate FDSOI MOSFET were matched by using MathCAD and silvaco respectively.

  18. A Comparative Analysis for Verification of IMRT and VMAT Treatment Plans using a 2-D and 3-D Diode Array

    NASA Astrophysics Data System (ADS)

    Dance, Michael J.

    With the added complexity of current radiation treatment dose delivery modalities such as IMRT (Intensity Modulated Radiation Therapy) and VMAT (Volumetric Modulated Arc Therapy), quality assurance (QA) of these plans become multifaceted and labor intensive. To simplify the patient specific quality assurance process, 2D or 3D diode arrays are used to measure the radiation fluence for IMRT and VMAT treatments which can then be quickly and easily compared against the planned dose distribution. Because the arrays that can be used for IMRT and VMAT patient-specific quality assurance are of different geometry (planar vs. cylindrical), the same IMRT or VMAT treatment plan measured by two different arrays could lead to different measured radiation fluences, regardless of the output and performance of linear accelerator. Thus, the purpose of this study is to compare patient specific QA results as measured by the MapCHECK 2 and ArcCHECK diode arrays for the same IMRT and VMAT treatment plans to see if one diode array consistently provides a closer comparison to reference data. Six prostate and three thoracic spine IMRT treatment plans as well as three prostate and three thoracic spine VMAT treatment plans were produced. Radiotherapy plans for this study were generated using the Pinnacle TPS v9.6 (Philips Radiation Oncology Systems, Fitchburg, WI) using 6 MV, 6 MV FFF, and 10 MV x-ray beams from a Varian TrueBeam linear accelerator (Varian Medical Systems, Palo Alto, CA) with a 120-millenium multi-leaf collimator (MLC). Each IMRT and VMAT therapy plan was measured on Sun Nuclear's MapCHECK 2 and ArcCHECK diode arrays. IMRT measured data was compared with planned dose distribution using Sun Nuclear's 3DVH quality assurance software program using gamma analysis and dose-volume histograms for target volumes and critical structures comparison. VMAT arc plans measured on the MapCHECK 2 and ArcCHECK were compared using beam-by-beam analysis with the gamma evaluation method with

  19. 3D galaxy clustering with future wide-field surveys: Advantages of a spherical Fourier-Bessel analysis

    NASA Astrophysics Data System (ADS)

    Lanusse, F.; Rassat, A.; Starck, J.-L.

    2015-06-01

    figure of merit as a function of median redshift is higher for the 3D SFB method than for the 2D tomographic method. Conclusions: Constraints from the 3D SFB analysis are less sensitive to unavoidable systematics stemming from a redshift- and scale-dependent galaxy bias. Even for surveys that are optimised with tomography in mind, a 3D SFB analysis is more powerful. In addition, for survey optimisation, the figure of merit for the 3D SFB method increases more rapidly with redshift, especially at higher redshifts, suggesting that the 3D SFB method should be preferred for designing and analysing future wide-field spectroscopic surveys. CosmicPy, the Python package developed for this paper, is freely available at https://cosmicpy.github.io. Appendices are available in electronic form at http://www.aanda.org

  20. [Study of post-myocardial infarction ventricular aneurysms with equilibrium radionuclide angiography. Significance of Fourier analysis].

    PubMed

    de Sá, M E; Ferreira, R; Rebelo, J R; Nogueira, A; Baptista, A M; Ribeiro, C

    2001-05-01

    III 17.9%; p < .0001). LV ejection fraction was statistically different in the four groups considered (I = 30.0% +/- 3.7; II = 39.9% +/- 2.9; III = 49.0% +/- 2.5; IV = 62.0% +/- 3.2). The degree of phase delay in aneurysmatic zones was quantified by the phase histogram. Average value of phase for the left ventricle was 129.7 +/- 8.4 degrees, and for the aneurysm it was 238.0 +/- 5.0 with an average phase delay of 104.8 +/- 4.1 degrees. The association of phase and amplitude images and the measurements of phase and amplitude values on the histograms allowed the distinction of akinetic aneurysm (phase delay and low amplitude) from the dyskinetic aneurysms (phase delay and high amplitude). Half of the isotopic diagnosis of aneurysms have been confirmed by classic contrast angiography, and a third of then have undergone surgery. The two dyskinetic aneurysms that have been submitted to aneurysmectomy had pos-operative improvement of LV function. On summary, phase and amplitude analysis by the Fourier method, which is independent of LV geometry, showed that LV regions with high phase values are associated with severe regional wall motion abnormalities and low ejections fractions. The definition of the sequence and amplitude of ventricular contraction allows the distinction of akinetic and dyskinetic aneurysms, anticipating the method as a valid contribution for the screening of patients likely to benefit from aneurysmectomy. PMID:11515305

  1. A meshfree local RBF collocation method for anti-plane transverse elastic wave propagation analysis in 2D phononic crystals

    NASA Astrophysics Data System (ADS)

    Zheng, Hui; Zhang, Chuanzeng; Wang, Yuesheng; Sladek, Jan; Sladek, Vladimir

    2016-01-01

    In this paper, a meshfree or meshless local radial basis function (RBF) collocation method is proposed to calculate the band structures of two-dimensional (2D) anti-plane transverse elastic waves in phononic crystals. Three new techniques are developed for calculating the normal derivative of the field quantity required by the treatment of the boundary conditions, which improve the stability of the local RBF collocation method significantly. The general form of the local RBF collocation method for a unit-cell with periodic boundary conditions is proposed, where the continuity conditions on the interface between the matrix and the scatterer are taken into account. The band structures or dispersion relations can be obtained by solving the eigenvalue problem and sweeping the boundary of the irreducible first Brillouin zone. The proposed local RBF collocation method is verified by using the corresponding results obtained with the finite element method. For different acoustic impedance ratios, various scatterer shapes, scatterer arrangements (lattice forms) and material properties, numerical examples are presented and discussed to show the performance and the efficiency of the developed local RBF collocation method compared to the FEM for computing the band structures of 2D phononic crystals.

  2. Large-scale systematic analysis of 2D fingerprint methods and parameters to improve virtual screening enrichments.

    PubMed

    Sastry, Madhavi; Lowrie, Jeffrey F; Dixon, Steven L; Sherman, Woody

    2010-05-24

    A systematic virtual screening study on 11 pharmaceutically relevant targets has been conducted to investigate the interrelation between 8 two-dimensional (2D) fingerprinting methods, 13 atom-typing schemes, 13 bit scaling rules, and 12 similarity metrics using the new cheminformatics package Canvas. In total, 157 872 virtual screens were performed to assess the ability of each combination of parameters to identify actives in a database screen. In general, fingerprint methods, such as MOLPRINT2D, Radial, and Dendritic that encode information about local environment beyond simple linear paths outperformed other fingerprint methods. Atom-typing schemes with more specific information, such as Daylight, Mol2, and Carhart were generally superior to more generic atom-typing schemes. Enrichment factors across all targets were improved considerably with the best settings, although no single set of parameters performed optimally on all targets. The size of the addressable bit space for the fingerprints was also explored, and it was found to have a substantial impact on enrichments. Small bit spaces, such as 1024, resulted in many collisions and in a significant degradation in enrichments compared to larger bit spaces that avoid collisions. PMID:20450209

  3. Parasitic extraction and magnetic analysis for transformers, inductors and igbt bridge busbar with maxwell 2d and maxwell 3d simulation

    NASA Astrophysics Data System (ADS)

    Zhang, Ning

    This thesis presents the parasitic extraction and magnetic analysis for transformers, inductors, and IGBT bridge busbars with Maxwell 2D and Maxwell 3D simulation. In the first chapter, the magnetic field of a transformer in Maxwell 2D is analyzed. The parasitic capacitance between each winding of the transformer are extracted by Maxwell 2D. According to the actual dimensions, the parasitic capacitances are calculated. The results are verified by comparing with the measurement results from 4395A impedance analyzer. In the second chapter, two CM inductors are simulated in Maxwell 3D. One is the conventional winding inductor, the other one is the proposed one. The magnetic field distributions of different winding directions are analyzed. The analysis is verified by the simulation result. The last chapter introduces a technique to analyze, extract, and measure the parasitic inductance of planar busbars. With this technique, the relationship between self-inductance and mutual-inductance is analyzed. Secondly, a total inductance is calculated based on the developed technique. Thirdly, the current paths and the inductance on a planar busbar are investigated with DC-link capacitors. Furthermore, the analysis of the inductance is addressed. Ansys Q3D simulation and analysis are presented. Finally, the experimental verification is shown by the S-parameter measurement.

  4. Understanding connected surface-water/groundwater systems using Fourier analysis of daily and sub-daily head fluctuations

    NASA Astrophysics Data System (ADS)

    Acworth, R. I.; Rau, Gabriel C.; McCallum, Andrew M.; Andersen, Martin S.; Cuthbert, Mark O.

    2015-02-01

    The long-term monitoring records of hydraulic heads frequently contain fluctuations originating from different cyclic drivers. Fourier analysis applied to these records can reveal connected surface-water/groundwater system characteristics. The various components of the atmospheric tides, the earth tides and the presence of diurnal responses to evapotranspiration are identified and isolated through band-pass filtering of data recorded from both vented and absolute gauge transducers. The signature of the different cyclic drivers is contained in amplitude and phase of the various signal components and can be used to determine the degree of system confinement. A methodology is described for the calculation of barometric efficiency in confined aquifers based upon the amplitude of the M2 and S2 components of the earth and atmospheric tides. It is demonstrated that Fourier analysis of water-level fluctuations is a simple but underused tool that can help to characterise shallow groundwater systems.

  5. Chemometric Analysis of Multicomponent Biodegradable Plastics by Fourier Transform Infrared Spectrometry: The R-Matrix Method

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A new chemometric method based on absorbance ratios from Fourier transform infrared spectra was devised to analyze multicomponent biodegradable plastics. The method uses the BeerLambert law to directly compute individual component concentrations and weight losses before and after biodegradation of c...

  6. Franck-Condon Factors for Diatomics: Insights and Analysis Using the Fourier Grid Hamiltonian Method

    ERIC Educational Resources Information Center

    Ghosh, Supriya; Dixit, Mayank Kumar; Bhattacharyya, S. P.; Tembe, B. L.

    2013-01-01

    Franck-Condon factors (FCFs) play a crucial role in determining the intensities of the vibrational bands in electronic transitions. In this article, a relatively simple method to calculate the FCFs is illustrated. An algorithm for the Fourier Grid Hamiltonian (FGH) method for computing the vibrational wave functions and the corresponding energy…

  7. Fourier-Transform Infrared Spectroscopy Analysis of Modified Cotton Trash Extracts

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In a previous study, Fourier transform infrared spectroscopy (FTIR) was utilized in identifying different types of botanical cotton trash as each was subjected to simulations of ginning and textile processing. Changes in the infrared spectra that occurred after heat treatment indicated that the nee...

  8. Fourier Descriptor Analysis and Unification of Voice Range Profile Contours: Method and Applications

    ERIC Educational Resources Information Center

    Pabon, Peter; Ternstrom, Sten; Lamarche, Anick

    2011-01-01

    Purpose: To describe a method for unified description, statistical modeling, and comparison of voice range profile (VRP) contours, even from diverse sources. Method: A morphologic modeling technique, which is based on Fourier descriptors (FDs), is applied to the VRP contour. The technique, which essentially involves resampling of the curve of the…

  9. 2D X-ray and FTIR micro-analysis of the degradation of cadmium yellow pigment in paintings of Henri Matisse

    NASA Astrophysics Data System (ADS)

    Pouyet, E.; Cotte, M.; Fayard, B.; Salomé, M.; Meirer, F.; Mehta, A.; Uffelman, E. S.; Hull, A.; Vanmeert, F.; Kieffer, J.; Burghammer, M.; Janssens, K.; Sette, F.; Mass, J.

    2015-11-01

    The chemical and physical alterations of cadmium yellow (CdS) paints in Henri Matisse's The Joy of Life (1905-1906, The Barnes Foundation) have been recognized since 2006, when a survey by portable X-ray fluorescence identified this pigment in all altered regions of the monumental painting. This alteration is visible as fading, discoloration, chalking, flaking, and spalling of several regions of light to medium yellow paint. Since that time, synchrotron radiation-based techniques including elemental and spectroscopic imaging, as well as X-ray scattering have been employed to locate and identify the alteration products observed in this and related works by Henri Matisse. This information is necessary to formulate one or multiple mechanisms for degradation of Matisse's paints from this period, and thus ensure proper environmental conditions for the storage and the display of his works. This paper focuses on 2D full-field X-ray Near Edge Structure imaging, 2D micro-X-ray Diffraction, X-ray Fluorescence, and Fourier Transform Infra-red imaging of the altered paint layers to address one of the long-standing questions about cadmium yellow alteration—the roles of cadmium carbonates and cadmium sulphates found in the altered paint layers. These compounds have often been assumed to be photo-oxidation products, but could also be residual starting reagents from an indirect wet process synthesis of CdS. The data presented here allow identifying and mapping the location of cadmium carbonates, cadmium chlorides, cadmium oxalates, cadmium sulphates, and cadmium sulphides in thin sections of altered cadmium yellow paints from The Joy of Life and Matisse's Flower Piece (1906, The Barnes Foundation). Distribution of various cadmium compounds confirms that cadmium carbonates and sulphates are photo-degradation products in The Joy of Life, whereas in Flower Piece, cadmium carbonates appear to have been a [(partially) unreacted] starting reagent for the yellow paint, a role

  10. Users manual for AUTOMESH-2D: A program of automatic mesh generation for two-dimensional scattering analysis by the finite element method

    NASA Technical Reports Server (NTRS)

    Hua, Chongyu; Volakis, John L.

    1990-01-01

    AUTOMESH-2D is a computer program specifically designed as a preprocessor for the scattering analysis of two dimensional bodies by the finite element method. This program was developed due to a need for reproducing the effort required to define and check the geometry data, element topology, and material properties. There are six modules in the program: (1) Parameter Specification; (2) Data Input; (3) Node Generation; (4) Element Generation; (5) Mesh Smoothing; and (5) Data File Generation.

  11. Analysis of Highly-Resolved Simulations of 2-D Humps Toward Improvement of Second-Moment Closures

    NASA Technical Reports Server (NTRS)

    Jeyapaul, Elbert; Rumsey Christopher

    2013-01-01

    Fully resolved simulation data of flow separation over 2-D humps has been used to analyze the modeling terms in second-moment closures of the Reynolds-averaged Navier- Stokes equations. Existing models for the pressure-strain and dissipation terms have been analyzed using a priori calculations. All pressure-strain models are incorrect in the high-strain region near separation, although a better match is observed downstream, well into the separated-flow region. Near-wall inhomogeneity causes pressure-strain models to predict incorrect signs for the normal components close to the wall. In a posteriori computations, full Reynolds stress and explicit algebraic Reynolds stress models predict the separation point with varying degrees of success. However, as with one- and two-equation models, the separation bubble size is invariably over-predicted.

  12. Performance analysis of 2D asynchronous hard-limiting optical code-division multiple access system through atmospheric scattering channel

    NASA Astrophysics Data System (ADS)

    Zhao, Yaqin; Zhong, Xin; Wu, Di; Zhang, Ye; Ren, Guanghui; Wu, Zhilu

    2013-09-01

    Optical code-division multiple access (OCDMA) systems usually allocate orthogonal or quasi-orthogonal codes to the active users. When transmitting through atmospheric scattering channel, the coding pulses are broadened and the orthogonality of the codes is worsened. In truly asynchronous case, namely both the chips and the bits are asynchronous among each active user, the pulse broadening affects the system performance a lot. In this paper, we evaluate the performance of a 2D asynchronous hard-limiting wireless OCDMA system through atmospheric scattering channel. The probability density function of multiple access interference in truly asynchronous case is given. The bit error rate decreases as the ratio of the chip period to the root mean square delay spread increases and the channel limits the bit rate to different levels when the chip period varies.

  13. Numerical analysis of InSb parameters and InSb 2D infrared focal plane arrays

    NASA Astrophysics Data System (ADS)

    Zhang, Xiaolei; Zhang, Hongfei; Sun, Weiguo; Zhang, Lei; Meng, Chao; Lu, Zhengxiong

    2012-10-01

    Accurate and reliable numerical simulation tools are necessary for the development of advanced semiconductor devices. InSb is using the MATLAB and TCAD simulation tool to calculatet the InSb body bandstructure, blackbody's radiant emittance and simultaneously solve the Poisson, Continuity and transport equations for 2D detector structures. In this work the material complexities of InSb, such as non-parabolicity, degenergcy, mobility and Auger recombination/generation are explained, and physics based models are developed. The Empirical Tight Binding Method (ETBM) was been using to calculate the bandstructure for InSb at 77 K by Matlab. We describe a set of systematic experiments performed in order to calibrate the simulation to semiconductor devices backside illuminated InSb focal plane arrays realized with planar technology. The spectral photoresponse and crosstalk characteristic for mid-wavelength InSb infrared focal plane arrays have been numerically studied.

  14. Inertial solvation in femtosecond 2D spectra

    NASA Astrophysics Data System (ADS)

    Hybl, John; Albrecht Ferro, Allison; Farrow, Darcie; Jonas, David

    2001-03-01

    We have used 2D Fourier transform spectroscopy to investigate polar solvation. 2D spectroscopy can reveal molecular lineshapes beneath ensemble averaged spectra and freeze molecular motions to give an undistorted picture of the microscopic dynamics of polar solvation. The transition from "inhomogeneous" to "homogeneous" 2D spectra is governed by both vibrational relaxation and solvent motion. Therefore, the time dependence of the 2D spectrum directly reflects the total response of the solvent-solute system. IR144, a cyanine dye with a dipole moment change upon electronic excitation, was used to probe inertial solvation in methanol and propylene carbonate. Since the static Stokes' shift of IR144 in each of these solvents is similar, differences in the 2D spectra result from solvation dynamics. Initial results indicate that the larger propylene carbonate responds more slowly than methanol, but appear to be inconsistent with rotational estimates of the inertial response. To disentangle intra-molecular vibrations from solvent motion, the 2D spectra of IR144 will be compared to the time-dependent 2D spectra of the structurally related nonpolar cyanine dye HDITCP.

  15. Development of an integrated approach for evaluation of 2-D gel image analysis: Impact of multiple proteins in single spots on comparative proteomics in conventional 2-D gel/MALDI workflow

    Technology Transfer Automated Retrieval System (TEKTRAN)

    With 2-D gel mapping, it is often observed that essentially identical proteins migrate to different positions in the gel, while some seemingly well-resolved protein spots consist of multiple proteins. These observations can undermine the validity of gel-based comparative proteomic studies. Through...

  16. High resolution infrared synchrotron study of CH2D81Br: ground state constants and analysis of the ν5, ν6 and ν9 fundamentals

    NASA Astrophysics Data System (ADS)

    Baldacci, A.; Stoppa, P.; Visinoni, R.; Wugt Larsen, R.

    2012-09-01

    The high resolution infrared absorption spectrum of CH2D81Br has been recorded by Fourier transform spectroscopy in the range 550-1075 cm-1, with an unapodized resolution of 0.0025 cm-1, employing a synchrotron radiation source. This spectral region is characterized by the ν6 (593.872 cm-1), ν5 (768.710 cm-1) and ν9 (930.295 cm-1) fundamental bands. The ground state constants up to sextic centrifugal distortion terms have been obtained for the first time by ground-state combination differences from the three bands and subsequently employed for the evaluation of the excited state parameters. Watson's A-reduced Hamiltonian in the Ir representation has been used in the calculations. The ν 6 = 1 level is essentially free from perturbation whereas the ν 5 = 1 and ν 9 = 1 states are mutually interacting through a-type Coriolis coupling. Accurate spectroscopic parameters of the three excited vibrational states and a high-order coupling constant which takes into account the interaction between ν5 and ν9 have been determined.

  17. The geometric phase analysis method based on the local high resolution discrete Fourier transform for deformation measurement

    NASA Astrophysics Data System (ADS)

    Dai, Xianglu; Xie, Huimin; Wang, Huaixi; Li, Chuanwei; Liu, Zhanwei; Wu, Lifu

    2014-02-01

    The geometric phase analysis (GPA) method based on the local high resolution discrete Fourier transform (LHR-DFT) for deformation measurement, defined as LHR-DFT GPA, is proposed to improve the measurement accuracy. In the general GPA method, the fundamental frequency of the image plays a crucial role. However, the fast Fourier transform, which is generally employed in the general GPA method, could make it difficult to locate the fundamental frequency accurately when the fundamental frequency is not located at an integer pixel position in the Fourier spectrum. This study focuses on this issue and presents a LHR-DFT algorithm that can locate the fundamental frequency with sub-pixel precision in a specific frequency region for the GPA method. An error analysis is offered and simulation is conducted to verify the effectiveness of the proposed method; both results show that the LHR-DFT algorithm can accurately locate the fundamental frequency and improve the measurement accuracy of the GPA method. Furthermore, typical tensile and bending tests are carried out and the experimental results verify the effectiveness of the proposed method.

  18. Fourier Transform Mass Spectrometry

    PubMed Central

    Scigelova, Michaela; Hornshaw, Martin; Giannakopulos, Anastassios; Makarov, Alexander

    2011-01-01

    This article provides an introduction to Fourier transform-based mass spectrometry. The key performance characteristics of Fourier transform-based mass spectrometry, mass accuracy and resolution, are presented in the view of how they impact the interpretation of measurements in proteomic applications. The theory and principles of operation of two types of mass analyzer, Fourier transform ion cyclotron resonance and Orbitrap, are described. Major benefits as well as limitations of Fourier transform-based mass spectrometry technology are discussed in the context of practical sample analysis, and illustrated with examples included as figures in this text and in the accompanying slide set. Comparisons highlighting the performance differences between the two mass analyzers are made where deemed useful in assisting the user with choosing the most appropriate technology for an application. Recent developments of these high-performing mass spectrometers are mentioned to provide a future outlook. PMID:21742802

  19. Quantitative Analysis of Isotope Distributions In Proteomic Mass Spectrometry Using Least-Squares Fourier Transform Convolution

    PubMed Central

    Sperling, Edit; Bunner, Anne E.; Sykes, Michael T.; Williamson, James R.

    2008-01-01

    Quantitative proteomic mass spectrometry involves comparison of the amplitudes of peaks resulting from different isotope labeling patterns, including fractional atomic labeling and fractional residue labeling. We have developed a general and flexible analytical treatment of the complex isotope distributions that arise in these experiments, using Fourier transform convolution to calculate labeled isotope distributions and least-squares for quantitative comparison with experimental peaks. The degree of fractional atomic and fractional residue labeling can be determined from experimental peaks at the same time as the integrated intensity of all of the isotopomers in the isotope distribution. The approach is illustrated using data with fractional 15N-labeling and fractional 13C-isoleucine labeling. The least-squares Fourier transform convolution approach can be applied to many types of quantitive proteomic data, including data from stable isotope labeling by amino acids in cell culture and pulse labeling experiments. PMID:18522437

  20. Single-Step Syngas-to-Distillates (S2D) Process Based on Biomass-Derived Syngas - A Techno-Economic Analysis

    SciTech Connect

    Zhu, Y.; Jones, S. B.; Biddy, M. J.; Dagle, R. A.; Palo, D. R.

    2012-08-01

    This study compared biomass gasification based syngas-to-distillate (S2D) systems using techno-economic analysis (TEA). Three cases, state of technology (SOT), goal, and conventional, were compared in terms of performance and cost. The SOT case represented the best available experimental results for a process starting with syngas using a single-step dual-catalyst reactor for distillate generation. The conventional case mirrored a conventional two-step S2D process consisting of separate syngas-to-methanol and methanol-to-gasoline (MTG) processes. The goal case assumed the same performance as the conventional, but with a single-step S2D technology. TEA results revealed that the SOT was more expensive than the conventional and goal cases. The SOT case suffers from low one-pass yield and high selectivity to light hydrocarbons, both of which drive up production cost. Sensitivity analysis indicated that light hydrocarbon yield and single pass conversion efficiency were the key factors driving the high cost for the SOT case.

  1. Discrete fourier transform (DFT) analysis for applications using iterative transform methods

    NASA Technical Reports Server (NTRS)

    Dean, Bruce H. (Inventor)

    2012-01-01

    According to various embodiments, a method is provided for determining aberration data for an optical system. The method comprises collecting a data signal, and generating a pre-transformation algorithm. The data is pre-transformed by multiplying the data with the pre-transformation algorithm. A discrete Fourier transform of the pre-transformed data is performed in an iterative loop. The method further comprises back-transforming the data to generate aberration data.

  2. FFTFIL; a filtering program based on two-dimensional Fourier analysis of geophysical data

    USGS Publications Warehouse

    Hildenbrand, T.G.

    1983-01-01

    The filtering program 'fftfil' performs a variety of operations commonly required in geophysical studies of gravity, magnetic, and terrain data. Filtering operations are carried out in the wave number domain where the Fourier coefficients of the input data are multiplied by the response of the selected filter. Input grids can be large (2=number of rows or columns=1024) and are not required to have numbers of rows and columns equal to powers of two.

  3. Field-of-view analysis of a polarization interference Fourier transform imaging spectrometer.

    PubMed

    DeHoog, Edward; Xia, Xiaowei; Parfenov, Alexander; Shih, Min-Yi

    2011-09-20

    The Fourier transform imaging spectrometer (FTIS) is an important tool for the measurement of spectral information in a scene. Advances in electro-optic crystal systems have led to the advent of the FTIS based on polarization interference filters. The operation of these devices as spectrometers has been well characterized, but the imaging capabilities have yet to be thoroughly explored. We explore the field-of-view limitations that occur when using this particular type of FTIS. PMID:21947057

  4. A Rapid and Efficient 2D/3D Nuclear Segmentation Method for Analysis of Early Mouse Embryo and Stem Cell Image Data

    PubMed Central

    Lou, Xinghua; Kang, Minjung; Xenopoulos, Panagiotis; Muñoz-Descalzo, Silvia; Hadjantonakis, Anna-Katerina

    2014-01-01

    Summary Segmentation is a fundamental problem that dominates the success of microscopic image analysis. In almost 25 years of cell detection software development, there is still no single piece of commercial software that works well in practice when applied to early mouse embryo or stem cell image data. To address this need, we developed MINS (modular interactive nuclear segmentation) as a MATLAB/C++-based segmentation tool tailored for counting cells and fluorescent intensity measurements of 2D and 3D image data. Our aim was to develop a tool that is accurate and efficient yet straightforward and user friendly. The MINS pipeline comprises three major cascaded modules: detection, segmentation, and cell position classification. An extensive evaluation of MINS on both 2D and 3D images, and comparison to related tools, reveals improvements in segmentation accuracy and usability. Thus, its accuracy and ease of use will allow MINS to be implemented for routine single-cell-level image analyses. PMID:24672759

  5. 2D Raman correlation analysis of formation mechanism of passivating film on overcharged LiCoO2 electrode with additive system

    NASA Astrophysics Data System (ADS)

    Park, Yeonju; Shin, Su Hyun; Lee, Sung Man; Kim, Sung Phil; Choi, Hyun Chul; Jung, Young Mee

    2014-07-01

    The effect of vinylene carbonate (VC) as solid electrolyte interface (SEI)-forming additive on the electrochemical performance of the LiCoO2 cathode was investigated by galvanostatic charge-discharge testing as well as Raman and 2D correlation spectroscopy. It was found that VC-containing electrolyte has a positive effect on capacity fading. An analysis of the 2D Raman correlation spectra suggested that even though the same SEI components (i.e., Co3O4 and Li2O) are produced on the cathode surface, the electrochemical reaction kinetics in the cathode/electrolyte interface differ according to the non-use or use of VC: in the latter case, formation of the SEI components is delayed.

  6. Proteomic expression of microfungal ripening starter Geotrichum candidum submitted to cold stress is strain-dependent: studies using 2d-dige technology and samespots software analysis.

    PubMed

    Missous, Ghalia; Thammavongs, Bouachanh; Dieuleveux, Virginie; Houssin, Maryline; Henry, Joël; Panoff, Jean-Michel

    2012-01-01

    Geotrichum candidum is a micro-fungus widely used as a ripening starter in cheese making. In anthropogenic environments such as dairy industries, this microorganism is subjected to many environmental and technological stresses including low temperature exposure. Our aim was to study the proteomic response of G. candidum to cold stress using a comparative proteomic approach by two-dimensional Differential In Gel Electrophoresis (2D DIGE). This technique consists on the labeling of proteins by specific fluorescent dyes (CyDyes). The results, obtained with G. candidum cells subjected to cold temperature, show significant proteomic patterns differences compared with the standard conditions. Furthermore, this biochemical response seems strain specific. 2D DIGE technology combined with SameSpots™ software analysis support these results through an important statistical validity. The comparative studies in a single gel, using two different fluorescent CyDyes (Cy3 and Cy5), lead to proteins differentiation. Selected spots were treated and analyzed by mass spectrometry. PMID:22987240

  7. Analysis of amorphous solid dispersions using 2D solid-state NMR and (1)H T(1) relaxation measurements.

    PubMed

    Pham, Tran N; Watson, Simon A; Edwards, Andrew J; Chavda, Manisha; Clawson, Jacalyn S; Strohmeier, Mark; Vogt, Frederick G

    2010-10-01

    Solid-state NMR (SSNMR) can provide detailed structural information about amorphous solid dispersions of pharmaceutical small molecules. In this study, the ability of SSNMR experiments based on dipolar correlation, spin diffusion, and relaxation measurements to characterize the structure of solid dispersions is explored. Observation of spin diffusion effects using the 2D (1)H-(13)C cross-polarization heteronuclear correlation (CP-HETCOR) experiment is shown to be a useful probe of association between the amorphous drug and polymer that is capable of directly proving glass solution formation. Dispersions of acetaminophen and indomethacin in different polymers are examined using this approach, as well as (1)H double-quantum correlation experiments to probe additional structural features. (1)H-(19)F CP-HETCOR serves a similar role for fluorinated drug molecules such as diflunisal in dispersions, providing a rapid means to prove the formation of a glass solution. Phase separation is detected using (13)C, (19)F, and (23)Na-detected (1)H T(1) experiments in crystalline and amorphous solid dispersions that contain small domains. (1)H T(1) measurements of amorphous nanosuspensions of trehalose and dextran illustrate the ability of SSNMR to detect domain size effects in dispersions that are not glass solutions via spin diffusion effects. Two previously unreported amorphous solid dispersions involving up to three components and containing voriconazole and telithromycin are analyzed using these experiments to demonstrate the general applicability of the approach. PMID:20681586

  8. Analysis of 2D Torus and Hub Topologies of 100Mb/s Ethernet for the Whitney Commodity Computing Testbed

    NASA Technical Reports Server (NTRS)

    Pedretti, Kevin T.; Fineberg, Samuel A.; Kutler, Paul (Technical Monitor)

    1997-01-01

    A variety of different network technologies and topologies are currently being evaluated as part of the Whitney Project. This paper reports on the implementation and performance of a Fast Ethernet network configured in a 4x4 2D torus topology in a testbed cluster of 'commodity' Pentium Pro PCs. Several benchmarks were used for performance evaluation: an MPI point to point message passing benchmark, an MPI collective communication benchmark, and the NAS Parallel Benchmarks version 2.2 (NPB2). Our results show that for point to point communication on an unloaded network, the hub and 1 hop routes on the torus have about the same bandwidth and latency. However, the bandwidth decreases and the latency increases on the torus for each additional route hop. Collective communication benchmarks show that the torus provides roughly four times more aggregate bandwidth and eight times faster MPI barrier synchronizations than a hub based network for 16 processor systems. Finally, the SOAPBOX benchmarks, which simulate real-world CFD applications, generally demonstrated substantially better performance on the torus than on the hub. In the few cases the hub was faster, the difference was negligible. In total, our experimental results lead to the conclusion that for Fast Ethernet networks, the torus topology has better performance and scales better than a hub based network.

  9. Monitoring post mortem changes in porcine muscle through 2-D DIGE proteome analysis of Longissimus muscle exudate

    PubMed Central

    2013-01-01

    Background Meat quality is a complex trait influenced by a range of factors with post mortem biochemical processes highly influential in defining ultimate quality. High resolution two-dimensional DIfference Gel Electrophoresis (2-D DIGE) and Western blot were applied to study the influence of post mortem meat ageing on the proteome of pork muscle. Exudate collected from the muscle following centrifugation was analysed at three timepoints representing a seven day meat ageing period. Results The intensity of 136 spots varied significantly (p < 0.05) across this post mortem period and 40 spots were identified using mass spectrometry. The main functional categories represented were metabolic proteins, stress-related proteins, transport and structural proteins. Metabolic and structural proteins were generally observed to increase in abundance post mortem and many likely represent the accumulation of the degradation products of proteolytic enzyme activity. In contrast, stress-related proteins broadly decreased in abundance across the ageing period. Stress response proteins have protective roles in maintaining cellular integrity and a decline in their abundance over time may correlate with a reduction in cellular integrity and the onset of meat ageing. Since cellular conditions alter with muscle ageing, changes in solubility may also contribute to observed abundance profiles. Conclusions Muscle exudate provided valuable information about the pathways and processes underlying the post mortem ageing period, highlighting the importance of post mortem modification of proteins and their interaction for the development of meat quality traits. PMID:23514628

  10. 2-D differential quadrature solution for vibration analysis of functionally graded conical, cylindrical shell and annular plate structures

    NASA Astrophysics Data System (ADS)

    Tornabene, Francesco; Viola, Erasmo; Inman, Daniel J.

    2009-12-01

    This paper focuses on the dynamic behavior of functionally graded conical, cylindrical shells and annular plates. The last two structures are obtained as special cases of the conical shell formulation. The first-order shear deformation theory (FSDT) is used to analyze the above moderately thick structural elements. The treatment is developed within the theory of linear elasticity, when materials are assumed to be isotropic and inhomogeneous through the thickness direction. The two-constituent functionally graded shell consists of ceramic and metal that are graded through the thickness, from one surface of the shell to the other. Two different power-law distributions are considered for the ceramic volume fraction. The homogeneous isotropic material is inferred as a special case of functionally graded materials (FGM). The governing equations of motion, expressed as functions of five kinematic parameters, are discretized by means of the generalized differential quadrature (GDQ) method. The discretization of the system leads to a standard linear eigenvalue problem, where two independent variables are involved without using the Fourier modal expansion methodology. For the homogeneous isotropic special case, numerical solutions are compared with the ones obtained using commercial programs such as Abaqus, Ansys, Nastran, Straus, Pro/Mechanica. Very good agreement is observed. Furthermore, the convergence rate of natural frequencies is shown to be very fast and the stability of the numerical methodology is very good. Different typologies of non-uniform grid point distributions are considered. Finally, for the functionally graded material case numerical results illustrate the influence of the power-law exponent and of the power-law distribution choice on the mechanical behavior of shell structures.

  11. Terahertz Spectroscopy and Global Analysis of the Bending Vibrations of ^{12}C_2H_2 and ^{12}C_2D_2

    NASA Astrophysics Data System (ADS)

    Yu, Shanshan; Drouin, Brian J.; Pearson, John C.; Pickett, Herbert M.; Lattanzi, Valerio; Walters, Adam

    2009-06-01

    Symmetric molecules have no permanent dipole moment and are undetectable by rotational spectroscopy. Their interstellar observations have previously been limited to mid-infrared vibration-rotation spectroscopy. Although relatively weak, vibrational difference bands provide a means for detection of non polar molecules by terahertz techniques with microwave precision. Herschel, SOFIA, and ALMA have the potential to identify a number of difference bands of light symmetric species, e.g., C_2H_2, CH_4 and C_3. This paper reports the results of the laboratory study on ^{12}C_2H_2 and ^{12}C_2D_2. The symmetric isotopomers of acetylene have two bending modes, the trans bending ν_4 (^1{π}_g), and the cis bending ν_5 (^1{π}_u). For ^{12}C_2H_2, the two bending modes occur at 612 and 729 cm^{-1}, respectively. For ^{12}C_2D_2, the two bending modes occur at 511 and 538 cm^{-1}. The ν_5-ν_4 difference bands are allowed and occur in the microwave, terahertz, and far-infrared wavelengths, with band origins at 117 cm^{-1} (3500 GHz) for ^{12}C_2H_2 and 27 cm^{-1} (900 GHz) for ^{12}C_2D_2. Two hundred and fifty-one ^{12}C_2D_2 transitions, which are from ν_5-ν_4, (ν_5+ν_4)-2ν_4 and 2ν_5-(ν_5+ν_4) bands, have been measured in the 0.2-1.6 THz region, and 202 of them were observed for the first time. The precision of these measurements is estimated to be from 50 kHz to 100 kHz. A multistate analysis was carried out for the bending vibrational modes ν_4 and ν_5 of ^{12}C_2D_2, which includes the lines observed in this work and prior microwave, far-infrared and infrared data on the pure bending levels. Significantly improved molecular parameters were obtained for ^{12}C_2D_2 by adding the new measurements to the old data set which had only 10 lines with microwave measurement precision. The experiments on ^{12}C_2H_2 are in progress and ten P branch lines have been observed. We will present the ^{12}C_2H_2 results to date.

  12. Development of achiral and chiral 2D HPLC methods for analysis of albendazole metabolites in microsomal fractions using multivariate analysis for the in vitro metabolism.

    PubMed

    Belaz, Kátia Roberta A; Pereira-Filho, Edenir Rodrigues; Oliveira, Regina V

    2013-08-01

    In this work, the development of two multidimensional liquid chromatography methods coupled to a fluorescence detector is described for direct analysis of microsomal fractions obtained from rat livers. The chiral multidimensional method was then applied for the optimization of the in vitro metabolism of albendazole by experimental design. Albendazole was selected as a model drug because of its anthelmintics properties and recent potential for cancer treatment. The development of two fully automated achiral-chiral and chiral-chiral high performance liquid chromatography (HPLC) methods for the determination of albendazole (ABZ) and its metabolites albendazole sulphoxide (ABZ-SO), albendazole sulphone (ABZ-SO2) and albendazole 2-aminosulphone (ABZ-SO2NH2) in microsomal fractions are described. These methods involve the use of a phenyl (RAM-phenyl-BSA) or octyl (RAM-C8-BSA) restricted access media bovine serum albumin column for the sample clean-up, followed by an achiral phenyl column (15.0×0.46cmI.D.) or a chiral amylose tris(3,5-dimethylphenylcarbamate) column (15.0×0.46cmI.D.). The chiral 2D HPLC method was applied to the development of a compromise condition for the in vitro metabolism of ABZ by means of experimental design involving multivariate analysis. PMID:23831523

  13. Aniso2D

    2005-07-01

    Aniso2d is a two-dimensional seismic forward modeling code. The earth is parameterized by an X-Z plane in which the seismic properties Can have monoclinic with x-z plane symmetry. The program uses a user define time-domain wavelet to produce synthetic seismograms anrwhere within the two-dimensional media.

  14. Analysis of the rotational spectrum of the ground and first torsional excited states of monodeuterated ethane, CH3CH2D

    NASA Astrophysics Data System (ADS)

    Daly, Adam M.; Drouin, Brian J.; Groner, Peter; Yu, Shanshan; Pearson, John C.

    2015-01-01

    The pure rotational spectrum of mono-deuterated ethane, CH3CH2D, has been measured up to 1600 GHz and spectroscopic constants have been fit to 984 transitions in the ground state and 422 transitions in the first torsional excited state (ν18). Analyses of the ground state data were performed with the programs SPFIT, ERHAM and XIAM and of the first torsional state with SPFIT and ERHAM to extract molecular and spectroscopic constants. A combined fit of both states using ERHAM was used to determine ρ = 0.4344026(68), which in the symmetric limit is the ratio Iα/Iz and a measure of the periodicity of the internal rotation energy with K and the energy differences between the A and E torsional substates, ΔE(E-A), of 74.167(18) and -3382.23(34) MHz for the ground and excited states, respectively. Using these energy differences and the overtone transitions Δv = 2 from Raman measurements in the literature, the coefficients V3 and V6 of the potential function of the internal rotation in CH3CH2D were determined as V3 = 1004.56(4) cm-1 and V6 = 7.09(12) cm-1. This analysis lays the ground work for the assignment of the IR spectrum of CH3CH2D between (680-880 cm-1) which will help quantify isotopic ratios by remote sensing missions.

  15. Analysis of the Advantages and Limitations of Stationary Imaging Fourier Transform Spectrometer. Revised

    NASA Technical Reports Server (NTRS)

    Beecken, Brian P.; Kleinman, Randall R.

    2004-01-01

    New developments in infrared sensor technology have potentially made possible a new space-based system which can measure far-infrared radiation at lower costs (mass, power and expense). The Stationary Imaging Fourier Transform Spectrometer (SIFTS) proposed by NASA Langley Research Center, makes use of new detector array technology. A mathematical model which simulates resolution and spectral range relationships has been developed for analyzing the utility of such a radically new approach to spectroscopy. Calculations with this forward model emulate the effects of a detector array on the ability to retrieve accurate spectral features. Initial computations indicate significant attenuation at high wavenumbers.

  16. Fourier Transform Infrared Spectroscopic Analysis Of Plastic Capsule Materials Exposed To Deuterium-Tritium (DT) Gas

    SciTech Connect

    Schoonover, J R; Steckle, Jr., W P; Elliot, N; Ebey, P S; Nobile, A; Nikroo, A; Cook, R C; Letts, S A

    2005-06-16

    Planar samples of varying thicknesses of both CH and CD glow discharge polymer have been measured with Fourier transform infrared (FTIR) spectroscopy before and after exposure to deuterium-tritium (DT) gas at elevated temperature and pressure. Planar samples of polyimide films made from both hydrogenated and deuterated precursors have also been examined by FTIR before and after DT exposure. The post-exposure FTIR spectra demonstrated no measurable exchange of hydrogen with deuterium or tritium for either polymer. Evidence for oxidation of the glow discharge polymer due to atmospheric oxygen was the only chemical change indicated by the FTIR data.

  17. Mid-Latitude Temperatures at 87 km: Results From Multi-Instrument Fourier Analysis

    NASA Technical Reports Server (NTRS)

    Drob, Douglas P.; Picone, J. M.; Eckermann, Stephen D.; She, C . Y.; Kafkalidis, J. F.; Ortland, D. A.; Niciejewski, R. J.; Killeen, T. L.

    2000-01-01

    Using a novel Fourier fitting method we combine two years of mid-latitude temperature measurements at 87 km from the High Resolution Doppler Imager, the Colorado State University lidar, and the Peach Mountain Interferometer. After accounting for calibration bias, significant local-time variations on the order of 10 K were observed. Stationary planetary waves with amplitudes up to 10 K were observed during winter, with weaker wave amplitudes occurring during other seasons. Because of calibration biases among these instruments, we could estimate the annual mean temperature to no better than 193.5 plus or minus 8.5 K.

  18. Characterizing the Nanoscale Layers of Tomorrow___s Electronics An Application of Fourier Analysis

    SciTech Connect

    Payne, Christopher Bishop; /Princeton U. /SLAC

    2012-08-24

    Thin film applications are of great interest to the semiconductor industry due to the important role they play in cutting edge technology such as thin film solar cells. X-Ray Reflectivity (XRR) characterizes thin films in a non-destructive and efficient manner yet complications exist in extracting these characteristics from raw XRR data. This study developed and tested two different algorithms to extract quantity of layers and thickness information on the nanometer scale from XRR data. It was concluded that an algorithm involving a local averaging technique revealed this information clearly in Fourier space.

  19. Single image orthogonal fringe technique for resolution enhancement of the Fourier transform fringe analysis method

    NASA Astrophysics Data System (ADS)

    Tavares, Paulo J.; Vaz, Mário A. P.

    2013-03-01

    Gradient range and spatial resolution in Fourier Transform Profilometry depend on the size of the filter window in reciprocal space. The proposed methods to date for the elimination of the fundamental frequency and enlargement of the filter window are either too computationally complex or depend on the possibility of using two frames, thus disabling the method's ability to cope with dynamic situations and subjecting the results to possible intensity changes between the two frame acquisitions. This article describes a simple method for using a single crossed fringe pattern to accomplish that objective, greatly improving the previously reported technique, whilst retaining its main advantages.

  20. Mid-latitude temperatures at 87 km: Results from multi-instrument Fourier analysis

    NASA Astrophysics Data System (ADS)

    Drob, Douglas P.; Picone, J. Michael; Eckermann, Stephen D.; She, C. Y.; Kafkalidis, J. F.; Ortland, D. A.; Niciejewski, R. J.; Killeen, T. L.

    2000-08-01

    Using a novel Fourier fitting method we combine two years of mid-latitude temperature measurements at 87 km from the High Resolution Doppler Imager, the Colorado State University lidar, and the Peach Mountain Interferometer. After accounting for calibration bias, significant local-time variations on the order of 10 K were observed. Stationary planetary waves with amplitudes up to 10 K were observed during winter, with weaker wave amplitudes occurring during other seasons. Because of calibration biases among these instruments, we could estimate the annual mean temperature to no better than 193.5±8.5 K.

  1. Environmental Analysis by ab Initio Quantum Mechanical Computation and Gas Chromatography/Fourier Transform Infrared Spectrometry.

    PubMed

    Gurka, D F; Titus, R; Robins, K; Wong, A; Wurrey, C J; Durig, J R; Shen, Z; Burkhard, L P

    1996-12-01

    Computational chemistry, in conjunction with gas chromatography/mass spectrometry/Fourier transform infrared spectrometry (GC/MS/FT-IR), was used to tentatively identify seven tetrachlorobutadiene (TCBD) isomers detected in an environmental sample. Computation of the TCBD infrared spectra was performed with the Gaussian quantum chemistry software. The Hartree-Fock/6-31G* level of theory was employed, with IR frequencies scaled by a standard factor of 0.89. This approach shows great promise as a means of characterizing or confirming environmental analyte identifications when standard spectra, or pure standards required to measure standard spectra, are unavailable. PMID:21619333

  2. Analysis of fixed point FFT for Fourier domain optical coherence tomography systems.

    PubMed

    Ali, Murtaza; Parlapalli, Renuka; Magee, David P; Dasgupta, Udayan

    2009-01-01

    Optical coherence tomography (OCT) is a new imaging modality gaining popularity in the medical community. Its application includes ophthalmology, gastroenterology, dermatology etc. As the use of OCT increases, the need for portable, low power devices also increases. Digital signal processors (DSP) are well suited to meet the signal processing requirements of such a system. These processors usually operate on fixed precision. This paper analyzes the issues that a system implementer faces implementing signal processing algorithms on fixed point processor. Specifically, we show the effect of different fixed point precisions in the implementation of FFT on the sensitivity of Fourier domain OCT systems. PMID:19965018

  3. Fourier transform C-13 NMR analysis of some free and potassium-ion complexed antibiotics.

    NASA Technical Reports Server (NTRS)

    Ohnishi, M.; Fedarko, M.-C.; Baldeschwieler, J. D.; Johnson, L. F.

    1972-01-01

    Fourier transforms of the noise-decoupled, natural abundance C-13 NMR free induction decays of the cyclic antibiotic valinomycin and its potassium-ion complex have been obtained at 25.2 MHz. Comparisons are made with C-13 NMR spectra taken at 22.6 MHz of the cyclic antibiotic nonactin and the synthetic polyether dicyclohexyl-18-crown-6 and their potassium complexes. The results obtained suggest that conformational rearrangements of the molecule as a whole can compete with direct interactions between carbons and the potassium ion in determining C-13 chemical shift differences between the free and complexed species.

  4. Calibration of wavefront distortion in light modulator setup by Fourier analysis of multibeam interference.

    PubMed

    Leszczyński, Adam; Wasilewski, Wojciech

    2016-04-01

    We present a method to calibrate wavefront distortion of the spatial light modulator setup by registering far-field images of several Gaussian beams diffracted off the modulator. The Fourier transform of resulting interference images reveals phase differences among typically five movable points on the modulator. Repeating this measurement yields a wavefront surface. Next, the amplitude efficiency is calibrated for registering the near-field image. For verification, we produced a superposition of seventh and eighth Bessel beams with different phase velocities and observed their interference. PMID:27140780

  5. Fourier analysis of Solar atmospheric numerical simulations accelerated with GPUs (CUDA).

    NASA Astrophysics Data System (ADS)

    Marur, A.

    2015-12-01

    Solar dynamics from the convection zone creates a variety of waves that may propagate through the solar atmosphere. These waves are important in facilitating the energy transfer between the sun's surface and the corona as well as propagating energy throughout the solar system. How and where these waves are dissipated remains an open question. Advanced 3D numerical simulations have furthered our understanding of the processes involved. Fourier transforms to understand the nature of the waves by finding the frequency and wavelength of these waves through the simulated atmosphere, as well as the nature of their propagation and where they get dissipated. In order to analyze the different waves produced by the aforementioned simulations and models, Fast Fourier Transform algorithms will be applied. Since the processing of the multitude of different layers of the simulations (of the order of several 100^3 grid points) would be time intensive and inefficient on a CPU, CUDA, a computing architecture that harnesses the power of the GPU, will be used to accelerate the calculations.

  6. Effect of spectral resolution on pattern recognition analysis using passive fourier transform infrared sensor data

    SciTech Connect

    Bangalore, Arjun S.; Demirgian, Jack C.; Boparai, Amrit S.; Small, Gary W.

    1999-11-01

    The Fourier transform infrared (FT-IR) spectral data of two nerve agent simulants, diisopropyl methyl phosphonate (DIMP) and dimethyl methyl phosphonate (DMMP), are used as test cases to determine the spectral resolution that gives optimal pattern recognition performance. DIMP is used as the target analyte for detection, while DMMP is used to test the ability of the automated pattern recognition methodology to detect the analyte selectively. Interferogram data are collected by using a Midac passive FT-IR instrument. The methodology is based on the application of pattern recognition techniques to short segments of single-beam spectra obtained by Fourier processing the collected interferogram data. The work described in this article evaluates the effect of varying spectral resolution on the pattern recognition results. The objective is to determine the optimal spectral resolution to be used for data collection. The results of this study indicate that the data with a nominal spectral resolution of 16 cm{sup -1} provide sufficient selectivity to give pattern recognition results comparable to that obtained by using higher resolution data. We found that, while higher resolution does not increase selectivity sufficiently to provide better pattern recognition results, lower resolution decreases selectivity and degrades the pattern recognition results. These results can be used as guidelines to maximize detection sensitivity, to minimize the time needed for data collection, and to reduce data storage requirements. (c) 2000 Society for Applied Spectroscopy.

  7. A fractional Fourier transform analysis of the scattering of ultrasonic waves

    PubMed Central

    Tant, Katherine M.M.; Mulholland, Anthony J.; Langer, Matthias; Gachagan, Anthony

    2015-01-01

    Many safety critical structures, such as those found in nuclear plants, oil pipelines and in the aerospace industry, rely on key components that are constructed from heterogeneous materials. Ultrasonic non-destructive testing (NDT) uses high-frequency mechanical waves to inspect these parts, ensuring they operate reliably without compromising their integrity. It is possible to employ mathematical models to develop a deeper understanding of the acquired ultrasonic data and enhance defect imaging algorithms. In this paper, a model for the scattering of ultrasonic waves by a crack is derived in the time–frequency domain. The fractional Fourier transform (FrFT) is applied to an inhomogeneous wave equation where the forcing function is prescribed as a linear chirp, modulated by a Gaussian envelope. The homogeneous solution is found via the Born approximation which encapsulates information regarding the flaw geometry. The inhomogeneous solution is obtained via the inverse Fourier transform of a Gaussian-windowed linear chirp excitation. It is observed that, although the scattering profile of the flaw does not change, it is amplified. Thus, the theory demonstrates the enhanced signal-to-noise ratio permitted by the use of coded excitation, as well as establishing a time–frequency domain framework to assist in flaw identification and classification. PMID:25792967

  8. [Detection of Syrup Adulterants in Prepackaged Pure Pineapple Juice by Fourier-Transform Infrared Spectroscopy and Chemometric Analysis].

    PubMed

    Zhou, Mi; Ke, Jian; Li, Bao-li; Tang, Cui-e; Tan, Jun; Liu, Rui; Wang, Hong; Li, Tao; Zhou, Sheng-yin

    2015-10-01

    This study was performed to establish a method that can quickly and accurately identify adulterated syrup in the pure pineapple juice. A attenuated total internal refraction-fourier transform infrared spectroscopy was used to collect the range of 900 -1 500 cm(-1) infrared spectra of 234 samples pure pineapple juice and adulterated syrup by beet syrup, rice syrup and cassava syrup. By using linear discriminant analysis and support vector machine for the identification model, comparing the full spectral and selected wavelengths based on principal component analysis loading plots of the two models to identify adulteration. Studies showed that the correct rate of validation set by linear discriminant analysis and support vector machine model on full spectral were both higher than 88%, variables were significantly reduced from 312 to 8 after selecting the eight characteristic wavelengths, the correct rate of validation set by linear discriminant analysis model was up to 96.15% and support vector machine was increase to 94.87%. The results demonstrated that the model built using a attenuated total internal refraction-fourier transform infrared spectroscopy in combination with chemometric methods after selected characteristic wavelengths could be used for the identification of the adulterated syrup in the pure pineapple juice. PMID:26904809

  9. Vertical density contrast and mapping of basement, Conrad and Moho morphologies through 2D spectral analysis of gravity data in and around Odisha, India

    NASA Astrophysics Data System (ADS)

    Kumar, Arbind; S. Roy, P. N.; Das, L. K.

    2016-07-01

    Power spectrum analysis of Complete Bouguer Anomaly (CBA) map of Eastern Ghat Mobile Belt (EGMB) and its surroundings in India through Two Dimensional (2D) spectral analysis has provided estimates of the ensemble average depths for the density discontinuities which represent crustal inhomogeneities. The spectral analysis method has helped to estimate the depths of a perturbing body sources which are obtained from the negative slopes of the linear relationship between the logarithmic power spectrum and the wave-numbers of the gravity field. The detailed analysis reveals three horizontal discontinuities (i) Phanerozoic sediment thickness (ii) Basement depth and (iii) Conrad discontinuity. The average thickness of Phanerozoic sediments is estimated to be 3 km whereas depth of basement and Conrad discontinuity are at 7 km and 14.5 km respectively. Additionally Mohorovicic discontinuity also estimated at a depth of 32.8 km in the study region.

  10. Mesh2d

    SciTech Connect

    Greg Flach, Frank Smith

    2011-12-31

    Mesh2d is a Fortran90 program designed to generate two-dimensional structured grids of the form [x(i),y(i,j)] where [x,y] are grid coordinates identified by indices (i,j). The x(i) coordinates alone can be used to specify a one-dimensional grid. Because the x-coordinates vary only with the i index, a two-dimensional grid is composed in part of straight vertical lines. However, the nominally horizontal y(i,j0) coordinates along index i are permitted to undulate or otherwise vary. Mesh2d also assigns an integer material type to each grid cell, mtyp(i,j), in a user-specified manner. The complete grid is specified through three separate input files defining the x(i), y(i,j), and mtyp(i,j) variations.

  11. Mesh2d

    2011-12-31

    Mesh2d is a Fortran90 program designed to generate two-dimensional structured grids of the form [x(i),y(i,j)] where [x,y] are grid coordinates identified by indices (i,j). The x(i) coordinates alone can be used to specify a one-dimensional grid. Because the x-coordinates vary only with the i index, a two-dimensional grid is composed in part of straight vertical lines. However, the nominally horizontal y(i,j0) coordinates along index i are permitted to undulate or otherwise vary. Mesh2d also assignsmore » an integer material type to each grid cell, mtyp(i,j), in a user-specified manner. The complete grid is specified through three separate input files defining the x(i), y(i,j), and mtyp(i,j) variations.« less

  12. Analysis of F-Canyon Effluents During the Dissolution Cycle with a Fourier Transform Infrared Spectrometer/Multipath Cell

    SciTech Connect

    Villa, E.

    1999-07-28

    Air samples from F-Canyon effluents were collected at the F-Canyon stack and transported to a laboratory at the Savannah River Technology Center (SRTC) for analysis using a Fourier transform infrared spectrometer in conjunction with a multipath cell. Air samples were collected during the decladding and acid cuts of the dissolution of the irradiated aluminum-cladded slugs. The FTIR analyses of the air samples show the presence of NO2, NO, HNO2, N2O, SF6, and 85Kr during the dissolution cycle. The concentration time profiles of these effluents corresponded with expected release rates from the F-Canyon operations.

  13. Vertical 2D Heterostructures

    NASA Astrophysics Data System (ADS)

    Lotsch, Bettina V.

    2015-07-01

    Graphene's legacy has become an integral part of today's condensed matter science and has equipped a whole generation of scientists with an armory of concepts and techniques that open up new perspectives for the postgraphene area. In particular, the judicious combination of 2D building blocks into vertical heterostructures has recently been identified as a promising route to rationally engineer complex multilayer systems and artificial solids with intriguing properties. The present review highlights recent developments in the rapidly emerging field of 2D nanoarchitectonics from a materials chemistry perspective, with a focus on the types of heterostructures available, their assembly strategies, and their emerging properties. This overview is intended to bridge the gap between two major—yet largely disjunct—developments in 2D heterostructures, which are firmly rooted in solid-state chemistry or physics. Although the underlying types of heterostructures differ with respect to their dimensions, layer alignment, and interfacial quality, there is common ground, and future synergies between the various assembly strategies are to be expected.

  14. Analytical determination of orbital elements using Fourier analysis. I. The radial velocity case

    NASA Astrophysics Data System (ADS)

    Delisle, J.-B.; Ségransan, D.; Buchschacher, N.; Alesina, F.

    2016-05-01

    We describe an analytical method for computing the orbital parameters of a planet from the periodogram of a radial velocity signal. The method is very efficient and provides a good approximation of the orbital parameters. The accuracy is mainly limited by the accuracy of the computation of the Fourier decomposition of the signal which is sensitive to sampling and noise. Our method is complementary with more accurate (and more expensive in computer time) numerical algorithms (e.g. Levenberg-Marquardt, Markov chain Monte Carlo, genetic algorithms). Indeed, the analytical approximation can be used as an initial condition to accelerate the convergence of these numerical methods. Our method can be applied iteratively to search for multiple planets in the same system.

  15. [Analysis of different parts of scorpio by Fourier transform infrared spectroscopy].

    PubMed

    Zhang, Sheng-Jun; Xu, Chang-Hua; Chen, Jian-Bo; Zhou, Qun; Sun, Su-Qin

    2011-10-01

    Fourier transform infrared (FTIR) spectroscopy and second derivative IR spectroscopy were applied to analyze and evaluate different parts of Scorpio. The second derivative IR spectra show clear differences while the origin spectra are quite similar. It was found that proteins are the dominant components in each part and the tail has distinct proteins compared to the others; fats are mainly stored in the trunk; sulfates are ubiquitous in all parts. Interestingly, the back part of the trunk of degenerative Scorpio contains some purine. It was demonstrated that FTIR spectroscopy integrated with second derivative IR spectroscopy not only can offer a fast, comprehensive and objective methodology for analyzing and evaluating the micro-differences among the various parts of same medicinal materials, but also can provide a rational guidance for medicinal and pharmacological studies. PMID:22250541

  16. Analysis of Distribution of Time Scores in Iterative Learning Type Courseware Using Fourier Transform

    NASA Astrophysics Data System (ADS)

    Watanabe, Hiroyuki

    In this research, an iterative learning type courseware was made, the distribution of time scores in the courseware is gotten by the learning management system. It is a proposed method by which the distribution of time scores is changed to frequency and to power spectrum using Fourier Transform. The learning process continues until students get the passing scores and are classified by using these values, which are related to average time and the average of scores‧ square. Furthermore, the cross-correlation coefficients between the standard student and students are calculated, and delay times are analyzed. Finally, the transfer functions of some students are calculated, and the characteristics of the learning processes are analyzed.

  17. Polyphase-discrete Fourier transform spectrum analysis for the Search for Extraterrestrial Intelligence sky survey

    NASA Technical Reports Server (NTRS)

    Zimmerman, G. A.; Gulkis, S.

    1991-01-01

    The sensitivity of a matched filter-detection system to a finite-duration continuous wave (CW) tone is compared with the sensitivities of a windowed discrete Fourier transform (DFT) system and an ideal bandpass filter-bank system. These comparisons are made in the context of the NASA Search for Extraterrestrial Intelligence (SETI) microwave observing project (MOP) sky survey. A review of the theory of polyphase-DFT filter banks and its relationship to the well-known windowed-DFT process is presented. The polyphase-DFT system approximates the ideal bandpass filter bank by using as few as eight filter taps per polyphase branch. An improvement in sensitivity of approx. 3 dB over a windowed-DFT system can be obtained by using the polyphase-DFT approach. Sidelobe rejection of the polyphase-DFT system is vastly superior to the windowed-DFT system, thereby improving its performance in the presence of radio frequency interference (RFI).

  18. Aperiodic-Fourier modal method for analysis of body-of-revolution photonic structures.

    PubMed

    Bigourdan, Florian; Hugonin, Jean-Paul; Lalanne, Philippe

    2014-06-01

    Modeling the field produced by a point-like dipole with an arbitrary location in the presence of a rotationally invariant nanostructure is an important issue in the context of designing nanoantennas. This is a challenging problem, as rotational symmetry is broken when introducing a noncentered dipole. Antennas larger than the wavelength are required for directivity, whereas the dipole-antenna distance is highly subwavelength, so there are two different length scales in the problem. In this paper, we introduce an original S-matrix approach based on an aperiodic-Fourier modal method. The potential of the technique is illustrated by considering three examples. We compare our results with a finite element technique. PMID:24977369

  19. Electrically compensated Fourier transform ion cyclotron resonance cell for complex mixture mass analysis.

    PubMed

    Kaiser, Nathan K; Savory, Joshua J; McKenna, Amy M; Quinn, John P; Hendrickson, Christopher L; Marshall, Alan G

    2011-09-01

    Complex natural organic mixtures such as petroleum require ultrahigh mass spectral resolution to separate and identify thousands of elemental compositions. Here, we incorporate a custom-built, voltage-compensated ICR cell for Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS), based on a prior design by Tolmachev to produce optimal mass resolution. The compensated ICR cell installed in a custom-built 9.4 T FTICR mass spectrometer consists of seven cylindrical segments with axial proportions designed to generate a dc trapping potential that approaches an ideal three-dimensional axial quadrupolar potential. However, the empirically optimized compensation voltages do not correspond to the most quadrupolar trapping field. The compensation electrodes minimize variation in the reduced cyclotron frequency by balancing imperfections in the magnetic and electric field. The optimized voltages applied to compensation electrodes preserve ion cloud coherence for longer transient duration by approximately a factor of 2, enabling separation and identification of isobaric species (compounds with the same nominal mass but different exact mass) common in petroleum, such as C(3) vs SH(4) (separated by 3.4 mDa) and SH(3)(13)C vs (12)C(4) (separated by 1.1 mDa). The improved performance of the ICR cell provides more symmetric peak shape and better mass measurement accuracy. A positive ion atmospheric pressure photoionization (APPI) petroleum spectrum yields more than 26,000 assigned peaks, Fourier-limited resolving power of 800,000 at m/z 500 (6.6 s transient duration), and 124 part per billion root mean square (rms) error. The tunability of the compensation electrodes is critical for optimal performance. PMID:21838231

  20. High-throughput morphometric analysis of pulmonary airways in MSCT via a mixed 3D/2D approach

    NASA Astrophysics Data System (ADS)

    Ortner, Margarete; Fetita, Catalin; Brillet, Pierre-Yves; Pr"teux, Françoise; Grenier, Philippe

    2011-03-01

    Asthma and COPD are complex airway diseases with an increased incidence estimated for the next decade. Today, the mechanisms and relationships between airway structure/physiology and the clinical phenotype and genotype are not completely understood. We thus lack the tools to predict disease progression or therapeutic responses. One of the main causes is our limited ability to assess the complexity of airway diseases in large populations of patients with appropriate controls. Multi-slice computed tomography (MSCT) imaging opened the way to the non-invasive assessment of airway physiology and structure, but the use of such technology in large cohorts requires a high degree of automation of the measurements. This paper develops an investigation framework and the associated image quantification tools for high-throughput analysis of airways in MSCT. A mixed approach is proposed, combining 3D and cross-section measurements of the airway tree where the user-interaction is limited to the choice of the desired analysis patterns. Such approach relies on the fully-automated segmentation of the 3D airway tree, caliber estimation and visualization based on morphologic granulometry, central axis computation and tree segment selection, cross-section morphometry of airway lumen and wall, and bronchus longitudinal shape analysis for stenosis/bronciectasis detection and measure validation. The developed methodology has been successfully applied to a cohort of 96 patients from a multi-center clinical study of asthma control in moderate and persistent asthma.

  1. Analysis of B-Raf[Formula: see text] inhibitors using 2D and 3D-QSAR, molecular docking and pharmacophore studies.

    PubMed

    Aalizadeh, Reza; Pourbasheer, Eslam; Ganjali, Mohammad Reza

    2015-11-01

    In the present work, a molecular modeling study was carried out using 2D and 3D quantitative structure-activity relationships for the various series of compounds known as B-Raf[Formula: see text] inhibitors. For 2D-QSAR analysis, a linear model was developed by MLR based on GA-OLS with appropriate results [Formula: see text], which was validated by several external validation techniques. To perform a 3D-QSAR analysis, CoMFA and CoMSIA methods were used. The selected CoMFA model could provide reliable statistical values [Formula: see text] based on the training set in the biases of the selected alignment. Using the same selected alignment, a statistically reliable CoMSIA model, out of thirty-one different combinations, was also obtained [Formula: see text]. The predictive accuracy of the derived models was rigorously evaluated with the external test set of nineteen compounds based on several validation techniques. Molecular docking simulations and pharmacophore analyses were also performed to derive the true conformations of the most potent inhibitors with B-Raf[Formula: see text] kinase. PMID:26276566

  2. 2D Flood Modelling Using Advanced Terrain Analysis Techniques And A Fully Continuous DEM-Based Rainfall-Runoff Algorithm

    NASA Astrophysics Data System (ADS)

    Nardi, F.; Grimaldi, S.; Petroselli, A.

    2012-12-01

    Remotely sensed Digital Elevation Models (DEMs), largely available at high resolution, and advanced terrain analysis techniques built in Geographic Information Systems (GIS), provide unique opportunities for DEM-based hydrologic and hydraulic modelling in data-scarce river basins paving the way for flood mapping at the global scale. This research is based on the implementation of a fully continuous hydrologic-hydraulic modelling optimized for ungauged basins with limited river flow measurements. The proposed procedure is characterized by a rainfall generator that feeds a continuous rainfall-runoff model producing flow time series that are routed along the channel using a bidimensional hydraulic model for the detailed representation of the inundation process. The main advantage of the proposed approach is the characterization of the entire physical process during hydrologic extreme events of channel runoff generation, propagation, and overland flow within the floodplain domain. This physically-based model neglects the need for synthetic design hyetograph and hydrograph estimation that constitute the main source of subjective analysis and uncertainty of standard methods for flood mapping. Selected case studies show results and performances of the proposed procedure as respect to standard event-based approaches.

  3. Comparison of 2D Finite Element Modeling Assumptions with Results From 3D Analysis for Composite Skin-Stiffener Debonding

    NASA Technical Reports Server (NTRS)

    Krueger, Ronald; Paris, Isbelle L.; OBrien, T. Kevin; Minguet, Pierre J.

    2004-01-01

    The influence of two-dimensional finite element modeling assumptions on the debonding prediction for skin-stiffener specimens was investigated. Geometrically nonlinear finite element analyses using two-dimensional plane-stress and plane-strain elements as well as three different generalized plane strain type approaches were performed. The computed skin and flange strains, transverse tensile stresses and energy release rates were compared to results obtained from three-dimensional simulations. The study showed that for strains and energy release rate computations the generalized plane strain assumptions yielded results closest to the full three-dimensional analysis. For computed transverse tensile stresses the plane stress assumption gave the best agreement. Based on this study it is recommended that results from plane stress and plane strain models be used as upper and lower bounds. The results from generalized plane strain models fall between the results obtained from plane stress and plane strain models. Two-dimensional models may also be used to qualitatively evaluate the stress distribution in a ply and the variation of energy release rates and mixed mode ratios with delamination length. For more accurate predictions, however, a three-dimensional analysis is required.

  4. Evaluation of Accuracy for 2D Elastic-Plastic Analysis by Embedded Force Doublet Model Combined with Automated Delaunay Tessellation

    NASA Astrophysics Data System (ADS)

    Ino, Takuichiro; Hasib, M. D. Abdul; Takase, Toru; Saimoto, Akihide

    2015-03-01

    An embedded force doublet (EFD) model is proposed to express the presence of permanent strain in body force method (BFM). BFM is known as a boundary type method for elastic stress analysis based on the principle of superposition. In EFD model, the permanent strain is replaced by distributed force doublets. In an actual elastic-plastic analysis, the plastic region whose shape is not clear a priori, have to be discretized into elements where the magnitude of embedded force doublets is unknown to be determined numerically. In general, the determination process of magnitude of EFD is considerably difficult due to nonlinear nature of yield criterion and plastic constitutive relations. In this study, by introducing the automated Delaunay tessellation scheme for discretizing the prospective plastic region, appreciable reduction in input data was realized. Adding to this, in order to improve the computational efficiency, influence coefficients used for determining the magnitude of EFD are stored in a database. The effectiveness of these two inventions was examined by computing the elastic-plastic problem of an infinite medium with circular hole subjected to uniform internal pressure. The numerical solution was compared with Nadai’s closed form solution and found a good agreement.

  5. Introduction to Fourier Optics

    ERIC Educational Resources Information Center

    Huggins, Elisha

    2007-01-01

    Much like a physical prism, which displays the frequency components of a light wave, Fourier analysis can be thought of as a mathematical prism that can tell us what harmonics or frequency components are contained in a recording of a sound wave. We wrote the MacScope II program so that the user could not only see a plot of the harmonic amplitudes…

  6. Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC⬜MS, and quantitative HPLC analysis.

    PubMed

    Elkins, Phyllis; Coleman, Donna; Burgess, Jason; Gardner, Michael; Hines, John; Scott, Brendan; Kroenke, Michelle; Larson, Jami; Lightner, Melissa; Turner, Gregory; White, Jonathan; Liu, Paul

    2014-01-01

    (Z)-Endoxifen (4-hydroxy-N-desmethyltamoxifen), an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than tamoxifen. In the MCF-7 human mammary tumor xenograft model with female athymic mice, (Z)-endoxifen, at an oral dose of 4⬜8 mg/kg, significantly inhibits tumor growth. (Z)-Endoxifen's potential as an alternative therapeutic agent independent of CYP2D6 activities, which can vary widely in ER+ breast cancer patients, is being actively evaluated. This paper describes confirmation of the configuration of the active (Z)-isomer through 2D NMR experiments, including NOE (ROESY) to establish spatial proton⬜proton correlations, and identification of the major impurity as the (E)-isomer in endoxifen drug substance by HPLC/HRMS (HPLC/MS-TOF). Stability of NMR solutions was confirmed by HPLC/UV analysis. For pre-clinical studies, a reverse-phase HPLC⬜UV method, with methanol/water mobile phases containing 10 mM ammonium formate at pH 4.3, was developed and validated for the accurate quantitation and impurity profiling of drug substance and drug product. Validation included demonstration of linearity, method precision, accuracy, and specificity in the presence of impurities, excipients (for the drug product), and degradation products. Ruggedness and reproducibility of the method were confirmed by collaborative studies between two independent laboratories. The method is being applied for quality control of the API and oral drug product. Kinetic parameters of Z- to E-isomerization were also delineated in drug substance and in aqueous formulation, showing conversion at temperatures above 25 °C. PMID:24055701

  7. 2D DIGE proteomic analysis highlights delayed postnatal repression of α-fetoprotein expression in homocystinuria model mice.

    PubMed

    Kamata, Shotaro; Akahoshi, Noriyuki; Ishii, Isao

    2015-01-01

    Cystathionine β-synthase-deficient (Cbs (-/-)) mice, an animal model for homocystinuria, exhibit hepatic steatosis and juvenile semilethality via as yet unknown mechanisms. The plasma protein profile of Cbs (-/-) mice was investigated by proteomic analysis using two-dimensional difference gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight/mass spectrometry. We found hyperaccumulation of α-fetoprotein (AFP) and downregulation of most other plasma proteins. AFP was highly expressed in fetal liver, but its expression declined dramatically via transcriptional repression after birth in both wild-type and Cbs (-/-) mice. However, the repression was delayed in Cbs (-/-) mice, causing high postnatal AFP levels, which may relate to transcriptional repression of most plasma proteins originating from liver and the observed hepatic dysfunction. PMID:26199862

  8. Construction and Analysis of a Novel 2-D Optical Orthogonal Codes Based on Modified One-coincidence Sequence

    NASA Astrophysics Data System (ADS)

    Ji, Jianhua; Wang, Yanfen; Wang, Ke; Xu, Ming; Zhang, Zhipeng; Yang, Shuwen

    2013-09-01

    A new two-dimensional OOC (optical orthogonal codes) named PC/MOCS is constructed, using PC (prime code) for time spreading and MOCS (modified one-coincidence sequence) for wavelength hopping. Compared with PC/PC, the number of wavelengths for PC/MOCS is not limited to a prime number. Compared with PC/OCS, the length of MOCS need not be expanded to the same length of PC. PC/MOCS can be constructed flexibly, and also can use available wavelengths effectively. Theoretical analysis shows that PC/MOCS can reduce the bit error rate (BER) of OCDMA system, and can support more users than PC/PC and PC/OCS.

  9. Quantitative analysis of morphological changes in yeast colonies growing on solid medium: the eccentricity and Fourier indices.

    PubMed

    Gil de Prado, Elena; Rivas, Eva-María; de Silóniz, María-Isabel; Diezma, Belén; Barreiro, Pilar; Peinado, José M

    2014-11-01

    The colony shape of four yeast species growing on agar medium was measured for 116 days by image analysis. Initially, all the colonies are circular, with regular edges. The loss of circularity can be quantitatively estimated by the eccentricity index, Ei , calculated as the ratio between their orthogonal vertical and horizontal diameters. Ei can increase from 1 (complete circularity) to a maximum of 1.17-1.30, depending on the species. One colony inhibits its neighbour only when it has reached a threshold area. Then, Ei of the inhibited colony increases proportionally to the area of the inhibitory colony. The initial distance between colonies affects those threshold values but not the proportionality, Ei /area; this inhibition affects the shape but not the total surface of the colony. The appearance of irregularities in the edges is associated, in all the species, not with age but with nutrient exhaustion. The edge irregularity can be quantified by the Fourier index, Fi , calculated by the minimum number of Fourier coefficients that are needed to describe the colony contour with 99% fitness. An ad hoc function has been developed in Matlab v. 7.0 to automate the computation of the Fourier coefficients. In young colonies, Fi has a value between 2 (circumference) and 3 (ellipse). These values are maintained in mature colonies of Debaryomyces, but can reach values up to 14 in Saccharomyces. All the species studied showed the inhibition of growth in facing colony edges, but only three species showed edge irregularities associated with substrate exhaustion. PMID:25100432

  10. Self-diffusion of polycrystalline ice Ih under confining pressure: Hydrogen isotope analysis using 2-D Raman imaging

    NASA Astrophysics Data System (ADS)

    Noguchi, Naoki; Kubo, Tomoaki; Durham, William B.; Kagi, Hiroyuki; Shimizu, Ichiko

    2016-08-01

    We have developed a high-resolution technique based on micro Raman spectroscopy to measure hydrogen isotope diffusion profiles in ice Ih. The calibration curve for quantitative analysis of deuterium in ice Ih was constructed using micro Raman spectroscopy. Diffusion experiments using diffusion couples composed of dense polycrystalline H2O and D2O ice were carried out under a gas confining pressure of 100 MPa (to suppress micro-fracturing and pore formation) at temperatures from 235 K to 245 K and diffusion times from 0.2 to 94 hours. Two-dimensional deuterium profiles across the diffusion couples were determined by Raman imaging. The location of small spots of frost from room air could be detected from the shapes of the Raman bands of OH and OD stretching modes, which change because of the effect of the molar ratio of deuterium on the molecular coupling interaction. We emphasize the validity for screening the impurities utilizing the coupling interaction. Some recrystallization and grain boundary migration occurred in recovered diffusion couples, but analysis of two-dimensional diffusion profiles of regions not affected by grain boundary migration allowed us to measure a volume diffusivity for ice at 100 MPa of (2.8 ± 0.4) ×10-3exp[ -57.0±15.4kJ/mol/RT ] m2 /s (R is the gas constant, T is temperature). Based on ambient pressure diffusivity measurements by others, this value indicates a high (negative) activation volume for volume diffusivity of -29.5 cm3/mol or more. We can also constrain the value of grain boundary diffusivity in ice at 100 MPa to be <104 that of volume diffusivity.

  11. Numerical analysis and synthesis of 2D quasi-optical reflectors and beam waveguides based on an integral-equation approach with Nystrom's discretization.

    PubMed

    Nosich, Andrey A; Gandel, Yuriy V; Magath, Thore; Altintas, Ayhan

    2007-09-01

    Considered is the beam wave guidance and scattering by 2D quasi-optical reflectors modeling the components of beam waveguides. The incident field is taken as the complex-source-point field to simulate a finite-width beam generated by a small-aperture source. A numerical solution is obtained from the coupled singular integral equations (SIEs) for the surface currents on reflectors, discretized by using the recently introduced Nystrom-type quadrature formulas. This analysis is applied to study what effect the edge illumination has on the performance of a chain of confocal elliptic reflectors. We also develop a semianalytical approach for shaped reflector synthesis after a prescribed near-field pattern. Here a new point is the use of auxiliary SIEs of the same type as in the scattering analysis problem, however, for the gradient of the objective function. Sample results are presented for the synthesis of a reflector-type beam splitter. PMID:17767252

  12. NOTE: A software tool for 2D/3D visualization and analysis of phase-space data generated by Monte Carlo modelling of medical linear accelerators

    NASA Astrophysics Data System (ADS)

    Neicu, Toni; Aljarrah, Khaled M.; Jiang, Steve B.

    2005-10-01

    A computer program has been developed for novel 2D/3D visualization and analysis of the phase-space parameters of Monte Carlo simulations of medical accelerator radiation beams. The software is written in the IDL language and reads the phase-space data generated in the BEAMnrc/BEAM Monte Carlo code format. Contour and colour-wash plots of the fluence, mean energy, energy fluence, mean angle, spectra distribution, energy fluence distribution, angular distribution, and slices and projections of the 3D ZLAST distribution can be calculated and displayed. Based on our experience of using it at Massachusetts General Hospital, the software has proven to be a useful tool for analysis and verification of the Monte Carlo generated phase-space files. The software is in the public domain.

  13. Diagnostic Accuracy of 2D-Shear Wave Elastography for Liver Fibrosis Severity: A Meta-Analysis

    PubMed Central

    Jiang, Tian’an; Tian, Guo; Zhao, Qiyu; Kong, Dexing; Cheng, Chao; Zhong, Liyun; Li, Lanjuan

    2016-01-01

    Purpose To evaluate the accuracy of shear wave elastography (SWE) in the quantitative diagnosis of liver fibrosis severity. Methods The published literatures were systematically retrieved from PubMed, Embase, Web of science and Scopus up to May 13th, 2016. Included studies reported the pooled sensitivity, specificity, positive and negative predictive values, as well as the diagnostic odds ratio of SWE in populations with liver fibrosis. A bivariate mixed-effects regression model was used, which was estimated by the I2 statistics. The quality of articles was evaluated by quality assessment of diagnostic accuracy studies (QUADAS). Results Thirteen articles including 2303 patients were qualified for the study. The pooled sensitivity and specificity of SWE for the diagnosis of liver fibrosis are as follows: ≥F1 0.76 (p<0.001, 95% CI, 0.71–0.81, I2 = 75.33%), 0.92 (p<0.001, 95% CI, 0.80–0.97, I2 = 79.36%); ≥F2 0.84 (p = 0.35, 95% CI, 0.81–0.86, I2 = 9.55%), 0.83 (p<0.001, 95% CI, 0.77–0.88, I2 = 86.56%); ≥F3 0.89 (p = 0.56, 95% CI, 0.86–0.92, I2 = 0%), 0.86 (p<0.001, 95% CI, 0.82–0.90, I2 = 75.73%); F4 0.89 (p = 0.24, 95% CI, 0.84–0.92, I2 = 20.56%), 0.88 (p<0.001, 95% CI, 0.84–0.92, I2 = 82.75%), respectively. Sensitivity analysis showed no significant changes if any one of the studies was excluded. Publication bias was not detected in this meta-analysis. Conclusions Our study suggests that SWE is a helpful method to appraise liver fibrosis severity. Future studies that validate these findings would be appropriate. PMID:27300569

  14. Hyporheic Exchange: Analysis of Aquifer Heterogeneity, Channel Morphology and Bedforms- 2D and 3D Simulations Using MODFLOW and MODPATH

    NASA Astrophysics Data System (ADS)

    Matos, J. R.; Welty, C.; Packman, A.

    2005-12-01

    The main purpose of the simulations in this research is the analysis of three-dimensional surface-groundwater interchange in heterogeneous systems. The effects of channel pattern, bed forms and aquifer heterogeneity on flow interactions between stream and groundwater systems are examined in order to contribute for a better understanding of the hyporheic process. A two-dimensional approach was also adopted to allow comparisons with the three-dimensional results. The grid was designed using the correlation scales of the heterogeneous fields and the scale of the stream meanders. MODFLOW and MODPATH were used to evaluate magnitude, direction and spatial distribution of the exchange flow. PMWIN and PMPATH were used as pre and post-processors during the construction of the models and analysis of results. Gaining and losing streams as well as parallel flow and flow across streams were simulated as idealized cases intended to describe how properties of the streambed and aquifer in low-gradient lowland streams contribute to hyporheic exchange. At first a straight river was analyzed then meandering streams were created with a sine curve and variations on wavelength and amplitude. Bed forms were simulated assuming a sinusoidal distribution of pressure head in the bed surface. Aspects of the influence of bedforms on mechanisms such as "pumping" and "turnover" are expected to be addressed with simulations. Flow velocities between 20 and 40 cm/s in the channel were tested with the objective of showing the influence of river morphology and natural bed forms on the flow exchange in the hyporheic zone. Several meander cycles and four levels of hydraulic conductivity variance were analyzed. Results of flow variances along the cross-sections and wetted perimeter show the increasing on hyporheic exchange as the degree of heterogeneity increases. Particle tracking was performed to define hyporheic residence time distributions. When comparing the homogeneous fields with all degrees of

  15. ZORNOC: a 1 1/2-D tokamak data analysis code for studying noncircular high beta plasmas

    SciTech Connect

    Zurro, B.; Wieland, R.M.; Murakami, M.; Swain, D.W.

    1980-03-01

    A new tokamak data analysis code, ZORNOC, was developed to study noncircular, high beta plasmas in the Impurity Study Experiment (ISX-B). These plasmas exhibit significant flux surface shifts and elongation in both ohmically heated and beam-heated discharges. The MHD equilibrium flux surface geometry is determined by solving the Grad-Shafranov equation based on: (1) the shape of the outermost flux surface, deduced from the magnetic loop probes; (2) a pressure profile, deduced by means of Thomson scattering data (electrons), charge exchange data (ions), and a Fokker-Planck model (fast ions); and (3) a safety factor profile, determined from the experimental data using a simple model (Z/sub eff/ = const) that is self-consistently altered while the plasma equilibrium is iterated. For beam-heated discharches the beam deposition profile is determined by means of a Monte Carlo scheme and the slowing down of the fast ions by means of an analytical solution of the Fokker-Planck equation. The code also carries out an electron power balance and calculates various confinement parameters. The code is described and examples of its operation are given.

  16. Fourier Analysis of Blazar Variability: Klein-Nishina Effects and the Jet Scattering Environment

    NASA Astrophysics Data System (ADS)

    Finke, Justin D.; Becker, Peter A.

    2015-08-01

    The strong variability of blazars can be characterized by power spectral densities (PSDs) and Fourier frequency-dependent time lags. In previous work, we created a new theoretical formalism for describing the PSDs and time lags produced via a combination of stochastic particle injection and emission via the synchrotron, synchrotron self-Compton, and external Compton (EC) processes. This formalism used the Thomson cross section and simple δ-function approximations to model the synchrotron and Compton emissivities. Here we expand upon this work, using the full Compton cross section and detailed and accurate emissivities. Our results indicate good agreement between the PSDs computed using the δ-function approximations and those computed using the accurate expressions, provided the observed photons are produced primarily by electrons with energies exceeding the lower limit of the injected particle population. Breaks are found in the PSDs at frequencies corresponding to the cooling timescales of the electrons primarily responsible for the observed emission, and the associated time lags are related to the difference in electron cooling timescales between the two energy channels, as expected. If the electron cooling timescales can be determined from the observed time lags and/or the observed EC PSDs, then one could in principle use the method developed here to determine the energy of the external seed photon source for EC, which is an important unsolved problem in blazar physics.

  17. The Spectrum and Term Analysis of Co III Measured Using Fourier Transform and Grating Spectroscopy

    NASA Astrophysics Data System (ADS)

    Smillie, D. G.; Pickering, J. C.; Nave, G.; Smith, P. L.

    2016-03-01

    The spectrum of Co iii has been recorded in the region 1562-2564 Å (64,000 cm-1-39,000 cm-1) by Fourier transform (FT) spectroscopy, and in the region 1317-2500 Å (164,000 cm-1-40,000 cm-1) using a 10.7 m grating spectrograph with phosphor image plate detectors. The spectrum was excited in a cobalt-neon Penning discharge lamp. We classified 514 Co iii lines measured using FT spectroscopy, the strongest having wavenumber uncertainties approaching 0.004 cm-1 (approximately 0.2 mÅ at 2000 Å, or 1 part in 107), and 240 lines measured with grating spectroscopy with uncertainties between 5 and 10 mÅ. The wavelength calibration of 790 lines of Raassen & Ortí Ortin and 87 lines from Shenstone has been revised and combined with our measurements to optimize the values of all but one of the 288 previously reported energy levels. Order of magnitude reductions in uncertainty for almost two-thirds of the 3d64s and almost half of the 3d64p revised energy levels are obtained. Ritz wavelengths have been calculated for an additional 100 forbidden lines. Eigenvector percentage compositions for the energy levels and predicted oscillator strengths have been calculated using the Cowan code.

  18. Analysis of hyper-spectral data derived from an imaging Fourier transform: A statistical perspective

    SciTech Connect

    Sengupta, S.K.; Clark, G.A.; Fields, D.J.

    1996-01-10

    Fourier transform spectrometers (FTS) using optical sensors are increasingly being used in various branches of science. Typically, a FTS generates a three-dimensional data cube with two spatial dimensions and one frequency/wavelength dimension. The number of frequency dimensions in such data cubes is generally very large, often in the hundreds, making data analytical procedures extremely complex. In the present report, the problem is viewed from a statistical perspective. A set of procedures based on the high degree of inter-channel correlation structure often present in such hyper-spectral data, has been identified and applied to an example data set of dimension 100 x 128 x 128 comprising 128 spectral bands. It is shown that in this case, the special eigen-structure of the correlation matrix has allowed the authors to extract just a few linear combinations of the channels (the significant principal vectors) that effectively contain almost all of the spectral information contained in the data set analyzed. This in turn, enables them to segment the objects in the given spatial frame using, in a parsimonious yet highly effective way, most of the information contained in the data set.

  19. [Stability analysis of on-board calibration system of spatially modulated imaging Fourier transform spectrometer].

    PubMed

    Gao, Jingz; Ji, Zhong-Ying; Wang, Zhong-Hou; Cui, Yan

    2010-04-01

    Spatially modulated imaging Fourier transform spectrometer (SMIFTS) was an instrument that depended on interference, and after calibration, the reconstruction spectrum can quantificationally reflect the diffuse reflection of target under sunshine. On-board calibration of SMIFTS confirmed the change of SMIFTS according to relative spectrum calibration, inspected long-time attenuation of SMIFTS optical system, and corrected export data of SMIFTS. According to the requirement of remote sensor application, it must stay in vacuum environment for a long time. As a radiant standard, the stability of lamp-house in long time is the most important characteristic of on-board calibration system. By calculation and experimentation, analyses of on-board calibration of SMIFTS, and testing spaceflight environment characteristic of on-board calibration, the difficulty in the key parts of on-board calibration of SMIFTS such as lamp-house, spectrum filter and integrating sphere was solved. According to the radiation-time stability testing for lamp-house and optics, particle-radiation testing, environmental-mechanics testing and hot vacuum examination, good result was obtained. By whole-aperture and part-field comparative wavelength calibration, the spectrum curve and before-launch interferogram were obtained. After comparison with reconstruction spectrum under different condition, the stability and credibility of SMIFTS on-board calibration system was proved. PMID:20545151

  20. Postoperative plasma metabolic consequences of an osseous substitute implantation: analysis by fourier transform infrared spectroscopy.

    PubMed

    Lorin, Chrystelle; Melin, Anne-Marie; Chenu, Jean-Patrick; Perromat, Annie; Déléris, Gérard

    2004-03-01

    In this study, we have investigated the postoperative plasma consequences of coral implantation into femoral condyle of rabbits. Analyses were performed using Fourier transform infrared (FT-IR) spectroscopy, a sensitive and nondestructive method, to evaluate plasma modifications one day, one week, one month, and three months after surgery. This technique showed that both surgery and implantation induced important changes of lipidic compounds one day after surgery, with a body lipolysis. Major modifications appeared one week after surgery, with a decrease of protein and saccharide contents, and an increase of amino acids accompanied by a noticeable inflammatory process. These last changes were revealed by a hierarchical classification in the 1430-1295 and 1137-1092 cm(-1) spectral regions, leading to two well-separated groups, before and one week after surgery. After a delayed time of three months and despite a substantial recovery for biomolecules such as proteins and fatty acids, some alterations are always observed, such as for amino acids, triglycerides, and glycerol. Moreover, molecules implicated in the inflammatory process had not reached their initial level. PMID:15035715

  1. Fourier transform infrared analysis of Tamra Bhasma at different levels: A preliminary study

    PubMed Central

    Chaudhari, Swapnil Y.; Rajput, Dhirajsingh S.; Galib, R.; Prajapati, Pradeep Kumar

    2015-01-01

    Introduction: Tamra Bhasma, one among the herbo-metallic preparations is extensively used in Ayurveda for different conditions. To make it safe to use, Tamra has to pass through a set of classical pharmaceutical procedures including a series of quenching in prescribed liquids, followed by incineration with black sulfide of mercury and herbal juice of Citrus jambhiri Lush. and corm of Amorphophallus campanulatus Linn. FTIR profiles of Tamra Bhasma at different levels is not available. Aim: To evaluate the chemical changes in Tamra Bhasma at different steps by following Fourier transform infrared (FTIR) spectroscopy. Materials and Methods: In current study, raw Tamra, intermediate samples obtained during purification, incineration and Amritikarana were analyzed using FTIR. Results: It was observed that Shodhana procedure leads in the formation of bonds between surface particles of Tamra and Shodhana media. These formed bonds on the surface of Shodhita Tamra samples gave various sharp peaks representing presence of many functional groups. Conclusion: The FTIR spectra revealed that both Bhasma samples contained organic compounds probably in the form of a complex with common functional groups like alkyl, methyl, etc., which need further studies for exact characterization of the complexes. PMID:26730144

  2. Attenuated total reflectance fourier transform infrared analysis of fly ash geopolymer gel aging.

    PubMed

    Rees, Catherine A; Provis, John L; Lukey, Grant C; van Deventer, Jannie S J

    2007-07-17

    Structural changes in fly ash geopolymers activated with different sodium hydroxide and silicate concentrations are investigated using attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy over a period of 200 days. A strong correlation is found between the concentration of silicate monomer in the activating solution and the position of the main Si-O-T stretching band in the FTIR spectrum, which gives an indication of the relative changes in the gel Si/Al ratio. The FTIR spectra of geopolymer samples with activating solution concentrations of up to 1.2 M SiO2 indicate that an Al-rich gel forms before the final gel composition is reached. The time required for the system to reach a steady gel composition depends on the silicate activating solution concentration and speciation. Geopolymers activated with solutions containing predominantly high-order silicate species rapidly reach a steady gel composition without first forming an Al-rich gel. A minimum silicate monomer concentration of approximately 0.6 M is required to shift the geopolymer synthesis mechanism from hydroxide activation to silicate activation. Silicate speciation in the activating solutions also affects zeolite formation and geopolymer microstructures, with a more homogeneous microstructure and less zeolite formation observed at a higher SiO2 content. PMID:17590027

  3. Semi-automated 2D Bruch's membrane shape analysis in papilledema using spectral-domain optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Wang, Jui-Kai; Sibony, Patrick A.; Kardon, Randy H.; Kupersmith, Mark J.; Garvin, Mona K.

    2015-03-01

    Recent studies have shown that the Bruch's membrane (BM) and retinal pigment epithelium (RPE), visualized on spectral-domain optical coherence tomography (SD-OCT), is deformed anteriorly towards the vitreous in patients with intracranial hypertension and papilledema. The BM/RPE shape has been quantified using a statistical-shape-model approach; however, to date, the approach has involved the tedious and time-consuming manual placement of landmarks and correspondingly, only the shape (and shape changes) of a limited number of patients has been studied. In this work, we first present a semi-automated approach for the extraction of 20 landmarks along the BM from an optic-nerve-head (ONH) centered OCT slice from each patient. In the approach, after the manual placement of the two Bruch's membrane opening (BMO) points, the remaining 18 landmarks are automatically determined using a graph-based segmentation approach. We apply the approach to the OCT scans of 116 patients (at baseline) enrolled in the Idiopathic Intracranial Hypertension Treatment Trial and generate a statistical shape model using principal components analysis. Using the resulting shape model, the coefficient (shape measure) corresponding to the second principal component (eigenvector) for each set of landmarks indicates the degree of the BM/RPE is oriented away from the vitreous. Using a subset of 20 patients, we compare the shape measure computed using this semi-automated approach with the resulting shape measure when (1) all landmarks are specified manually (Experiment I); and (2) a different expert specifies the two BMO points (Experiment II). In each case, a correlation coefficient >= 0.99 is obtained.

  4. Multislice T1 -prepared 2D single-shot EPI: analysis of a clinical T1 mapping method unbiased by B0 or B1 inhomogeneity.

    PubMed

    Lauzon, M Louis; McCreary, Cheryl R; Frayne, Richard

    2016-08-01

    Quantitative MR imaging is as sensitive in detecting lesions as qualitative imaging, but it is potentially more specific in differentiating disease. T1 mapping in particular might help to assess acute ischemic stroke, multiple sclerosis, epilepsy and Alzheimer's disease better. Thus, a rapid and robust clinical technique is vital. In 1990, Ordidge and colleagues developed the multislice T1 -prepared two-dimensional (2D) single-shot echo planar imaging technique. Subsequent studies demonstrated its clinical viability, but none performed an in-depth analysis of the strengths and advantages of this T1 mapping method. Herein, theoretical and experimental evidence shows that the technique accounts for 2D slice profile effects and is unbiased by B0 or B1 inhomogeneity. This is verified explicitly by varying the linear shims, the T1 preparation flip angle and the excitation flip angle. Furthermore, it is shown that the repetition time (and hence scan time) can be reduced without a loss of T1 accuracy. Copyright © 2016 John Wiley & Sons, Ltd. PMID:27331861

  5. Near-infrared (NIR) imaging analysis of polylactic acid (PLA) nanocomposite by multiple-perturbation two-dimensional (2D) correlation spectroscopy

    NASA Astrophysics Data System (ADS)

    Shinzawa, Hideyuki; Murakami, Takurou N.; Nishida, Masakazu; Kanematsu, Wataru; Noda, Isao

    2014-07-01

    Multiple-perturbation two-dimensional (2D) correlation spectroscopy was applied to sets of near-infrared (NIR) imaging data of polylactic acid (PLA) nanocomposite samples undergoing UV degradation. Incorporation of clay nanoparticles substantially lowers the surface free energy barrier for the nucleation of PLA and eventually increases the frequency of the spontaneous nucleation of PLA crystals. Thus, when exposed to external stimuli such as UV light, PLA nanocomposite may show different structure alternation depending on the clay dispersion. Multiple-perturbation 2D correlation analysis of the PLA nanocomposite samples revealed different spatial variation between crystalline and amorphous structure of PLA, and the phenomenon especially becomes acute in the region where the clay particles are coagulated. The incorporation of the clay leads to the cleavage-induced crystallization of PLA when the sample is subjected to the UV light. The additional development of the ordered crystalline structure then works favorably to restrict the initial degradation of the polymer, providing the delay in the weight loss of the PLA.

  6. Application of rank-ordered multifractal analysis (ROMA) to intermittent fluctuations in 3D turbulent flows, 2D MHD simulation and solar wind data

    NASA Astrophysics Data System (ADS)

    Wu, C.; Chang, T.

    2010-12-01

    A new method in describing the multifractal characteristics of intermittent events was introduced by Cheng and Wu [Chang T. and Wu C.C., Physical Rev, E77, 045401(R), 2008]. The procedure provides a natural connection between the rank-ordered spectrum and the idea of one-parameter scaling for monofractals. This technique has been demonstrated using results obtained from a 2D MHD simulation. It has also been successfully applied to in-situ solar wind observations [Chang T., Wu, C.C. and Podesta, J., AIP Conf Proc. 1039, 75, 2008], and the broadband electric field oscillations from the auroral zone [Tam, S.W.Y. et al., Physical Rev, E81, 036414, 2010]. We take the next step in this procedure. By using the ROMA spectra and the scaled probability distribution functions (PDFs), raw PDFs can be calculated, which can be compared directly with PDFs from observations or simulation results. In addition to 2D MHD simulation results and in-situ solar wind observation, we show clearly using the ROMA analysis the multifractal character of the 3D fluid simulation data obtained from the JHU turbulence database cluster at http://turbulence.pha.jhu.edu. In particular, we show the scaling of the non-symmetrical PDF for the parallel-velocity fluctuations of this 3D fluid data.

  7. Hip2Norm: an object-oriented cross-platform program for 3D analysis of hip joint morphology using 2D pelvic radiographs.

    PubMed

    Zheng, G; Tannast, M; Anderegg, C; Siebenrock, K A; Langlotz, F

    2007-07-01

    We developed an object-oriented cross-platform program to perform three-dimensional (3D) analysis of hip joint morphology using two-dimensional (2D) anteroposterior (AP) pelvic radiographs. Landmarks extracted from 2D AP pelvic radiographs and optionally an additional lateral pelvic X-ray were combined with a cone beam projection model to reconstruct 3D hip joints. Since individual pelvic orientation can vary considerably, a method for standardizing pelvic orientation was implemented to determine the absolute tilt/rotation. The evaluation of anatomically morphologic differences was achieved by reconstructing the projected acetabular rim and the measured hip parameters as if obtained in a standardized neutral orientation. The program had been successfully used to interactively objectify acetabular version in hips with femoro-acetabular impingement or developmental dysplasia. Hip(2)Norm is written in object-oriented programming language C++ using cross-platform software Qt (TrollTech, Oslo, Norway) for graphical user interface (GUI) and is transportable to any platform. PMID:17499878

  8. FPGA-based multi-channel fluorescence lifetime analysis of Fourier multiplexed frequency-sweeping lifetime imaging

    PubMed Central

    Zhao, Ming; Li, Yu; Peng, Leilei

    2014-01-01

    We report a fast non-iterative lifetime data analysis method for the Fourier multiplexed frequency-sweeping confocal FLIM (Fm-FLIM) system [ Opt. Express22, 10221 ( 2014)24921725]. The new method, named R-method, allows fast multi-channel lifetime image analysis in the system’s FPGA data processing board. Experimental tests proved that the performance of the R-method is equivalent to that of single-exponential iterative fitting, and its sensitivity is well suited for time-lapse FLIM-FRET imaging of live cells, for example cyclic adenosine monophosphate (cAMP) level imaging with GFP-Epac-mCherry sensors. With the R-method and its FPGA implementation, multi-channel lifetime images can now be generated in real time on the multi-channel frequency-sweeping FLIM system, and live readout of FRET sensors can be performed during time-lapse imaging. PMID:25321778

  9. Introducing Fourier-domain mobility spectrum analysis (FMSA) to deduce multi-component carrier mobility and density

    NASA Astrophysics Data System (ADS)

    Cui, Boya; Tang, Yang; Grayson, M.

    2015-01-01

    Compounds and heterostructures in optical devices often host multiple carrier species that contribute simultaneously to the total electrical conduction, making it difficult to distinguish the characteristics of each type. Here a Fourier-domain Mobility Spectrum Analysis (FMSA)1 is introduced to sort the conductivity contributions of different carrier species from magnetotransport measurements. Using simulated magnetotransport data from 0 to 15 T of a simple initial trial spectrum, FMSA iteratively adjusts the spectral points in either the mobility domain or its Fourier reciprocal space to fit a mobility range spanning over three orders of magnitude (μ = 670 ~ 1,000,000 cm2/V·s). With its alternating local and global adjustments, FMSA is able to recover the mobility distribution of test data, as verified in convergence plots of the total error as a function of iteration number. This technique resolves the mobility spectra as well or better than competing MSA techniques with a simple and elegant algorithm, while precisely resolving the smoothness and width of mobility peaks without artificial broadening.

  10. Fourier analysis of wing beat signals: assessing the effects of genetic alterations of flight muscle structure in Diptera.

    PubMed Central

    Hyatt, C J; Maughan, D W

    1994-01-01

    A method for determining and analyzing the wing beat frequency in Diptera is presented. This method uses an optical tachometer to measure Diptera wing movement during flight. The resulting signal from the optical measurement is analyzed using a Fast Fourier Transform (FFT) technique, and the dominant frequency peak in the Fourier spectrum is selected as the wing beat frequency. Also described is a method for determining quantitatively the degree of variability of the wing beat frequency about the dominant frequency. This method is based on determination of a quantity called the Hindex, which is derived using data from the FFT analysis. Calculation of the H index allows computer-based selection of the most suitable segment of recorded data for determination of the representative wing beat frequency. Experimental data suggest that the H index can also prove useful in examining wing beat frequency variability in Diptera whose flight muscle structure has been genetically altered. Examples from Drosophila indirect flight muscle studies as well as examples of artificial data are presented to illustrate the method. This method fulfills a need for a standardized method for determining wing beat frequencies and examining wing beat frequency variability in insects whose flight muscles have been altered by protein engineering methods. PMID:7811927

  11. Mandibular shape analysis in fossil hominins: Fourier descriptors in norma lateralis.

    PubMed

    Lestrel, P E; Wolfe, C A; Bodt, A

    2013-08-01

    Biological shape can be defined as the boundary of a form in 2-space (R(2)). An earlier study (Lestrel et al., 2010, HOMO-J. Comp. Hum. Biol.) of the cranial vault found that there were statistically significant differences between each of the three groups: H. erectus, H. heidelbergensis, and H. neanderthalensis compared with H. sapiens. In contrast, there was no statistically significant difference among the first three groups. These results suggest that these three groups may have formed single evolving lineage while H. sapiens represents a separate evolutionary development. The purpose of the current research was to discern if the mandible reflected a similar pattern as the cranial vault data. This study used lateral jpeg images of the mandible. Five fossil samples were used: A. robustus (n=7), H. erectus (n=12), H. heidelbergensis (n=4), H. neanderthalensis (n=22) and H. sapiens (n=61). Each mandible image was pre-processed with Photoshop Elements. Each image was then submitted to a specially written routine that digitized the 84 points along the mandible boundary. Each mandible was fitted with elliptical Fourier functions (EFFs). Procrustes superimposition was imposed to insure minimum shape differences. The mandible results largely mirrored the earlier cranial vault study with one exception. Statistically significant results were obtained for the mandible between the H. erectus and H. neanderthalensis samples in contrast to the earlier cranial vault data. F-tests disclosed that the statistical significance was limited to the anterior symphysis of the mandible. This mosaic pattern may be explained by the reduction in prognathism with the concomitant if rudimentary development of the chin as seen in H. neanderthalensis compared to H. erectus. PMID:23769600

  12. The dynamics of attentional sampling during visual search revealed by Fourier analysis of periodic noise interference.

    PubMed

    Dugué, Laura; Vanrullen, Rufin

    2014-01-01

    What are the temporal dynamics of perceptual sampling during visual search tasks, and how do they differ between a difficult (or inefficient) and an easy (or efficient) task? Does attention focus intermittently on the stimuli, or are the stimuli processed continuously over time? We addressed these questions by way of a new paradigm using periodic fluctuations of stimulus information during a difficult (color-orientation conjunction) and an easy (+ among Ls) search task. On each stimulus, we applied a dynamic visual noise that oscillated at a given frequency (2-20 Hz, 2-Hz steps) and phase (four cardinal phase angles) for 500 ms. We estimated the dynamics of attentional sampling by computing an inverse Fourier transform on subjects' d-primes. In both tasks, the sampling function presented a significant peak at 2 Hz; we showed that this peak could be explained by nonperiodic search strategies such as increased sensitivity to stimulus onset and offset. Specifically in the difficult task, however, a second, higher-frequency peak was observed at 9 to 10 Hz, with a similar phase for all subjects; this isolated frequency component necessarily entails oscillatory attentional dynamics. In a second experiment, we presented difficult search arrays with dynamic noise that was modulated by the previously obtained grand-average attention sampling function or by its converse function (in both cases omitting the 2 Hz component to focus on genuine oscillatory dynamics). We verified that performance was higher in the latter than in the former case, even for subjects who had not participated in the first experiment. This study supports the idea of a periodic sampling of attention during a difficult search task. Although further experiments will be needed to extend these findings to other search tasks, the present report validates the usefulness of this novel paradigm for measuring the temporal dynamics of attention. PMID:24525262

  13. Fourier Lucas-Kanade algorithm.

    PubMed

    Lucey, Simon; Navarathna, Rajitha; Ashraf, Ahmed Bilal; Sridharan, Sridha

    2013-06-01

    In this paper, we propose a framework for both gradient descent image and object alignment in the Fourier domain. Our method centers upon the classical Lucas & Kanade (LK) algorithm where we represent the source and template/model in the complex 2D Fourier domain rather than in the spatial 2D domain. We refer to our approach as the Fourier LK (FLK) algorithm. The FLK formulation is advantageous when one preprocesses the source image and template/model with a bank of filters (e.g., oriented edges, Gabor, etc.) as 1) it can handle substantial illumination variations, 2) the inefficient preprocessing filter bank step can be subsumed within the FLK algorithm as a sparse diagonal weighting matrix, 3) unlike traditional LK, the computational cost is invariant to the number of filters and as a result is far more efficient, and 4) this approach can be extended to the Inverse Compositional (IC) form of the LK algorithm where nearly all steps (including Fourier transform and filter bank preprocessing) can be precomputed, leading to an extremely efficient and robust approach to gradient descent image matching. Further, these computational savings translate to nonrigid object alignment tasks that are considered extensions of the LK algorithm, such as those found in Active Appearance Models (AAMs). PMID:23599053

  14. Fiber Optic Fourier Transform Infrared Spectroscopic Techniques for Advanced On-Line Chemical Analysis in Semiconductor Fabrication Tools

    NASA Astrophysics Data System (ADS)

    Kester, Michael; Trygstad, Marc; Chabot, Paul

    2003-09-01

    A unique analytical methodology has recently been developed to perform real-time, on-line chemical analysis of bath solutions in semiconductor fabrication tools. A novel, patented fiber optic sensor is used to transmit infrared light directly through the tube walls of the circulating bath solutions within the fabrication tool in a completely non-invasive, non-extractive way. The sensor simply "clips" onto the tubing, thus permitting immediate analysis of the bath composition by Fourier Transform infrared (FTIR) spectroscopy. The infrared spectrometer is capable of multiplexing up to eight "Clippir™" sensor heads to a single interferometer using fiber optic cables. The instrument can analyze almost any bath solution utilized today. The analysis is performed using the near-infrared (NIR) portion of the electromagnetic spectrum, where absorption bands related to molecular vibrations can be found. The Fourier Transform infrared spectrometer gives access to absorption bands over a wide range of frequencies (or wavelengths), and the absorptions are correlated to concentrations using a chemometric approach employing a partial least-squares algorithm. Models are generated from this approach for each chemistry to be analyzed. This paper will review the analytical technology necessary to make such measurements, and discuss the instrument performance criteria required to achieve accurate and precise measurements of bath chemistries. The ability to measure non-infrared absorbing compounds will be discussed, as will the nature of the influence of sample temperature on measurement. Issues critical to the development of robust models and their direct implementation on multiple channels and even different instruments will be considered.

  15. Rail inspection in track maintenance: A benchmark between the wavelet approach and the more conventional Fourier analysis

    NASA Astrophysics Data System (ADS)

    Caprioli, A.; Cigada, A.; Raveglia, D.

    2007-02-01

    Nowadays the power of data analysis tools like the wavelet decomposition of signals is well known and spread. On the other hand the theoretical advantages of such methods often fight with reality, when real field signals are collected and analysed: it sometimes comes out that this time-frequency approach somehow fails, demanding for a deeper insight into the kind of physical problem to be considered, and requiring a sort of "benchmark" between the traditional Fourier approach and the more recent time-frequency one. In this paper, sharply application-oriented, the possibilities offered by the wavelet techniques have been analysed: both the DSP specialist and the field engineer points of view have been joined to exploit the new approach of its best. A real problem has been considered, in which acceleration signals from a train bogie are collected and real-time analysed, to get a diagnostic tool to know the track condition of a subway line. This paper would like to look for a compromise point between complex mathematics based techniques, such as wavelet packet, sometimes hard to comprehend to the application engineer, and the physical meaning of these tools helping in fixing the real method limits. Therefore the aim is not just trying this analysis on an almost random process, like the accelerations measured on a running bogie, to locate defects, but rather a discussion on the development of the continuous and discrete wavelet transform, in comparison with the classical Fourier analysis or filter banks. Only the minimum mathematical background is provided in the text, with the needed references, to give tools fit for comprehending the physical meaning of the new tools, capable of sparing computing effort, while preserving or even improving the system effectiveness.

  16. A quantitative analysis of 2-D gels identifies proteins in which labeling is increased following long-term sensitization in Aplysia

    SciTech Connect

    Castellucci, V.F.; Kennedy, T.E.; Kandel, E.R.; Goelet, P. )

    1988-06-01

    Long-term memory for sensitization of the gill- and siphon-withdrawal reflex in Aplysia, produced by 4 days of training, is associated with increased synaptic efficacy of the connection between the sensory and motor neurons. This training is also accompanied by neuronal growth; there is an increase in the number of synaptic varicosities per sensory neuron and in the number of active zones. Such structural changes may be due to changes in the rates of synthesis of certain proteins. We have searched for proteins in which the rates of ({sup 35}S)methionine labeling are altered during the maintenance phase of long-term memory for sensitization by using computer-assisted quantitative 2-D gel analysis. This method has allowed us to detect 4 proteins in which labeling is altered after 4 days of sensitization training.

  17. Stratigraphic analysis of 3-D and 2-D seismic data to delineate porous carbonate debris flow in permian strata along the northwestern margin of the Midlan

    SciTech Connect

    Pacht, J.A.; Brooks, L.; Messa, F.

    1995-12-31

    Carbonate debris flow are very important plays in Leonard strata along the northwestern margin of the Midland Basin. Delineation of these strata, however, is difficult and detailed stratigraphic analysis of both 2D and 3D seismic data is important in reducing risk. Porous debris flows are best developed during lowstand time. When sea-level falls to a point at or below the shelf margin, sand to boulder-sized clasts created by reef-front erosion are funneled through slope gullies onto the base of the slope. Large debris flows exhibit well-defined mounds which downlap onto the sequence boundary. Many of these flows, however, are too thin to exhibit discrete reflections. 3D seismic data are used to define subtle changes in amplitude and frequency which suggest presence of porous strata. Along the northwest shelf, porous debris flows exhibit lower amplitude (dim spots) and lower frequency than surrounding strata. They are commonly developed immediately downdip of major slump scars.

  18. Fourier Transform Infrared Spectroscopy (FTIR) and Multivariate Analysis for Identification of Different Vegetable Oils Used in Biodiesel Production

    PubMed Central

    Mueller, Daniela; Ferrão, Marco Flôres; Marder, Luciano; da Costa, Adilson Ben; de Cássia de Souza Schneider, Rosana

    2013-01-01

    The main objective of this study was to use infrared spectroscopy to identify vegetable oils used as raw material for biodiesel production and apply multivariate analysis to the data. Six different vegetable oil sources—canola, cotton, corn, palm, sunflower and soybeans—were used to produce biodiesel batches. The spectra were acquired by Fourier transform infrared spectroscopy using a universal attenuated total reflectance sensor (FTIR-UATR). For the multivariate analysis principal component analysis (PCA), hierarchical cluster analysis (HCA), interval principal component analysis (iPCA) and soft independent modeling of class analogy (SIMCA) were used. The results indicate that is possible to develop a methodology to identify vegetable oils used as raw material in the production of biodiesel by FTIR-UATR applying multivariate analysis. It was also observed that the iPCA found the best spectral range for separation of biodiesel batches using FTIR-UATR data, and with this result, the SIMCA method classified 100% of the soybean biodiesel samples. PMID:23539030

  19. Discrimination of cultivation ages and cultivars of ginseng leaves using Fourier transform infrared spectroscopy combined with multivariate analysis

    PubMed Central

    Kwon, Yong-Kook; Ahn, Myung Suk; Park, Jong Suk; Liu, Jang Ryol; In, Dong Su; Min, Byung Whan; Kim, Suk Weon

    2013-01-01

    To determine whether Fourier transform (FT)-IR spectral analysis combined with multivariate analysis of whole-cell extracts from ginseng leaves can be applied as a high-throughput discrimination system of cultivation ages and cultivars, a total of total 480 leaf samples belonging to 12 categories corresponding to four different cultivars (Yunpung, Kumpung, Chunpung, and an open-pollinated variety) and three different cultivation ages (1 yr, 2 yr, and 3 yr) were subjected to FT-IR. The spectral data were analyzed by principal component analysis and partial least squares-discriminant analysis. A dendrogram based on hierarchical clustering analysis of the FT-IR spectral data on ginseng leaves showed that leaf samples were initially segregated into three groups in a cultivation age-dependent manner. Then, within the same cultivation age group, leaf samples were clustered into four subgroups in a cultivar-dependent manner. The overall prediction accuracy for discrimination of cultivars and cultivation ages was 94.8% in a cross-validation test. These results clearly show that the FT-IR spectra combined with multivariate analysis from ginseng leaves can be applied as an alternative tool for discriminating of ginseng cultivars and cultivation ages. Therefore, we suggest that this result could be used as a rapid and reliable F1 hybrid seed-screening tool for accelerating the conventional breeding of ginseng. PMID:24558311

  20. Fourier transform-infrared spectroscopy and Gas chromatography-mass spectroscopy: Reliable techniques for analysis of Parthenium mediated vermicompost

    NASA Astrophysics Data System (ADS)

    Rajiv, P.; Rajeshwari, Sivaraj; Venckatesh, Rajendran

    2013-12-01

    Fourier transform infrared spectroscopy (FT-IR) and Gas chromatography-mass spectroscopy have been carried out to investigate the chemical composition of Parthenium mediated vermicompost. Four different concentrations of Parthenium and cow dung mixtures were vermicomposted using the earthworms (Eudrilus eugeniae). FT-IR spectra reveal the absence of Parthenin toxin (sesquiterpene lactone) and phenols in vermicompost which was obtained from high concentration of cow dung mixed treatments. GC-MS analysis shows no phenolic compounds and predominant level of intermediate metabolites such as 4,8,12,16-Tetramethylheptadecan-4-olide (7.61%), 2-Pentadecanone, 6,10,14-trimethyl- (5.29%) and Methyl 16-methyl-heptadecanoate (4.69%) during the vermicomposting process. Spectral results indicated that Parthenin toxin and phenols can be eradicated via vermicomposting if mixed with appropriate quantity of cow dung.

  1. Isogyres - Manifestation of Spin-orbit interaction in uniaxial crystal: A closed-fringe Fourier analysis of conoscopic interference.

    PubMed

    Samlan, C T; Naik, Dinesh N; Viswanathan, Nirmal K

    2016-01-01

    Discovered in 1813, the conoscopic interference pattern observed due to light propagating through a crystal, kept between crossed polarizers, shows isochromates and isogyres, respectively containing information about the dynamic and geometric phase acquired by the beam. We propose and demonstrate a closed-fringe Fourier analysis method to disentangle the isogyres from the isochromates, leading us to the azimuthally varying geometric phase and its manifestation as isogyres. This azimuthally varying geometric phase is shown to be the underlying mechanism for the spin-to-orbital angular momentum conversion observed in a diverging optical field propagating through a z-cut uniaxial crystal. We extend the formalism to study the optical activity mediated uniaxial-to-biaxial transformation due to a weak transverse electric field applied across the crystal. Closely associated with the phase and polarization singularities of the optical field, the formalism enables us to understand crystal optics in a new way, paving the way to anticipate several emerging phenomena. PMID:27625210

  2. Stage-II-screening device for testing of heterogeneous catalysts in gas phase reactions with Fourier transform infrared analysis

    NASA Astrophysics Data System (ADS)

    Brüning, Rainer; Scholz, Peter; Ondruschka, Bernd

    2005-07-01

    The construction of a stage-II-screening device for heterogeneous catalysts in gas phase reactions under ambient pressure is described. The concentrations of the reaction products are determined by Fourier transform infrared analysis in combination with a chemometric interpretation of the obtained spectra. Thus, fast high-precision product analyses with complete mass balances are feasible, within the limits of accuracy of the measurements. The device is designed to screen up to 17 catalysts in one testing cycle. It is possible to determine temperature-conversion-selectivity dependencies as well as long-term measurements under constant conditions. With the help of the device described, the catalytic properties of new materials were parallel tested for the oxidative dehydrogenation of isopropanol.

  3. Simple, fast, and accurate methodology for quantitative analysis using Fourier transform infrared spectroscopy, with bio-hybrid fuel cell examples

    PubMed Central

    Mackie, David M.; Jahnke, Justin P.; Benyamin, Marcus S.; Sumner, James J.

    2016-01-01

    The standard methodologies for quantitative analysis (QA) of mixtures using Fourier transform infrared (FTIR) instruments have evolved until they are now more complicated than necessary for many users’ purposes. We present a simpler methodology, suitable for widespread adoption of FTIR QA as a standard laboratory technique across disciplines by occasional users.•Algorithm is straightforward and intuitive, yet it is also fast, accurate, and robust.•Relies on component spectra, minimization of errors, and local adaptive mesh refinement.•Tested successfully on real mixtures of up to nine components. We show that our methodology is robust to challenging experimental conditions such as similar substances, component percentages differing by three orders of magnitude, and imperfect (noisy) spectra. As examples, we analyze biological, chemical, and physical aspects of bio-hybrid fuel cells. PMID:26977411

  4. Diagnosis of Periodontal Disease from Saliva Samples Using Fourier Transform Infrared Microscopy Coupled with Partial Least Squares Discriminant Analysis.

    PubMed

    Fujii, Satoshi; Sato, Shinobu; Fukuda, Keisuke; Okinaga, Toshinori; Ariyoshi, Wataru; Usui, Michihiko; Nakashima, Keisuke; Nishihara, Tatsuji; Takenaka, Shigeori

    2016-01-01

    Diagnosis of periodontal disease by Fourier transform infrared (FT-IR) microscopic technique was achieved for saliva samples. Twenty-two saliva samples, collected from 10 patients with periodontal disease and 12 normal volunteers, were pre-processed and analyzed by FT-IR microscopy. We found that the periodontal samples showed a larger raw IR spectrum than the control samples. In addition, the shape of the second derivative spectrum was clearly different between the periodontal and control samples. Furthermore, the amount of saliva content and the mixture ratio were different between the two samples. Partial least squares discriminant analysis was used for the discrimination of periodontal samples based on the second derivative spectrum. The leave-one-out cross-validation discrimination accuracy was 94.3%. Thus, these results show that periodontal disease may be diagnosed by analyzing saliva samples with FT-IR microscopy. PMID:26860570

  5. Noise-band factor analysis of cancer Fourier transform infrared evanescent-wave fiber optical (FTIR-FEW) spectra

    NASA Astrophysics Data System (ADS)

    Sukuta, Sydney; Bruch, Reinhard F.

    2002-05-01

    The goal of this study is to test the feasibility of using noise factor/eigenvector bands as general clinical analytical tools for diagnoses. We developed a new technique, Noise Band Factor Cluster Analysis (NBFCA), to diagnose benign tumors via their Fourier transform IR fiber optic evanescent wave spectral data for the first time. The middle IR region of human normal skin tissue and benign and melanoma tumors, were analyzed using this new diagnostic technique. Our results are not in full-agreement with pathological classifications hence there is a possibility that our approaches could complement or improve these traditional classification schemes. Moreover, the use of NBFCA make it much easier to delineate class boundaries hence this method provides results with much higher certainty.

  6. Fourier transform-infrared spectroscopy and Gas chromatography-mass spectroscopy: reliable techniques for analysis of Parthenium mediated vermicompost.

    PubMed

    Rajiv, P; Rajeshwari, Sivaraj; Venckatesh, Rajendran

    2013-12-01

    Fourier transform infrared spectroscopy (FT-IR) and Gas chromatography-mass spectroscopy have been carried out to investigate the chemical composition of Parthenium mediated vermicompost. Four different concentrations of Parthenium and cow dung mixtures were vermicomposted using the earthworms (Eudrilus eugeniae). FT-IR spectra reveal the absence of Parthenin toxin (sesquiterpene lactone) and phenols in vermicompost which was obtained from high concentration of cow dung mixed treatments. GC-MS analysis shows no phenolic compounds and predominant level of intermediate metabolites such as 4,8,12,16-Tetramethylheptadecan-4-olide (7.61%), 2-Pentadecanone, 6,10,14-trimethyl- (5.29%) and Methyl 16-methyl-heptadecanoate (4.69%) during the vermicomposting process. Spectral results indicated that Parthenin toxin and phenols can be eradicated via vermicomposting if mixed with appropriate quantity of cow dung. PMID:23998948

  7. Assessing the spatial fidelity of resolution-enhanced imagery using Fourier analysis: a proof-of-concept study

    NASA Astrophysics Data System (ADS)

    Civco, Daniel L.; Witharana, Chandi

    2012-10-01

    Pan-sharpening of moderate resolution multispectral remote sensing data with those of a higher spatial resolution is a standard practice in remote sensing image processing. This paper suggests a method by which the spatial properties of resolution merge products can be assessed. Whereas there are several accepted metrics, such as correlation and root mean square error, for quantifying the spectral integrity of fused images, relative to the original multispectral data, there is less agreement on a means by which to assess the spatial properties, relative to the original higher-resolution, pansharpening data. In addition to qualitative, visual, and somewhat subjective evaluation, quantitative measures used have included correlations between high-pass filtered panchromatic and fused images, gradient analysis, wavelet analysis, among others. None of these methods, however, fully exploits the spatial and structural information contained in the original high resolution and fused images. This paper proposes the use of the Fourier transform as a means to quantify the degree to which a fused image preserves the spatial properties of the pan-sharpening high resolution data. A highresolution 8-bit panchromatic image was altered to produce a set of nine different test images, as well as a random image. The Fourier Magnitude (FM) image was calculated for each of the datasets and compared via FM to FM image correlation. Furthermore, the following edge detection algorithms were applied to the original and altered images: (a) Canny; (b) Sobel; and (c) Laplacian. These edge-filtered images were compared, again by way of correlation, with the original edge-filtered panchromatic image. Results indicate that the proposed method of using FTMI as a means of assessing the spatial fidelity of high-resolution imagery used in the data fusion process outperforms the correlations produced by way of comparing edge-enhanced images.

  8. Performance Analysis of Error Probabilities for Arbitrary 2-D Signaling with I/Q Unbalances over Nakagami-m Fading Channels

    NASA Astrophysics Data System (ADS)

    Lee, Jaeyoon; Yoon, Dongweon; Park, Sang Kyu

    Recently, we provided closed-form expressions involving two-dimensional (2-D) joint Gaussian Q-function for the symbol error rate (SER) and bit error rate (BER) of an arbitrary 2-D signal with I/Q unbalances over an additive white Gaussian noise (AWGN) channel [1]. In this letter, we extend the expressions to Nakagami-m fading channels. Using Craig representation of the 2-D joint Gaussian Q-function, we derive an exact and general expression for the error probabilities of arbitrary 2-D signaling with I/Q phase and amplitude unbalances over Nakagami-m fading channels.

  9. A Comparative Analysis of 2D and 3D Tasks for Virtual Reality Therapies Based on Robotic-Assisted Neurorehabilitation for Post-stroke Patients.

    PubMed

    Lledó, Luis D; Díez, Jorge A; Bertomeu-Motos, Arturo; Ezquerro, Santiago; Badesa, Francisco J; Sabater-Navarro, José M; García-Aracil, Nicolás

    2016-01-01

    Post-stroke neurorehabilitation based on virtual therapies are performed completing repetitive exercises shown in visual electronic devices, whose content represents imaginary or daily life tasks. Currently, there are two ways of visualization of these task. 3D virtual environments are used to get a three dimensional space that represents the real world with a high level of detail, whose realism is determinated by the resolucion and fidelity of the objects of the task. Furthermore, 2D virtual environments are used to represent the tasks with a low degree of realism using techniques of bidimensional graphics. However, the type of visualization can influence the quality of perception of the task, affecting the patient's sensorimotor performance. The purpose of this paper was to evaluate if there were differences in patterns of kinematic movements when post-stroke patients performed a reach task viewing a virtual therapeutic game with two different type of visualization of virtual environment: 2D and 3D. Nine post-stroke patients have participated in the study receiving a virtual therapy assisted by PUPArm rehabilitation robot. Horizontal movements of the upper limb were performed to complete the aim of the tasks, which consist in reaching peripheral or perspective targets depending on the virtual environment shown. Various parameter types such as the maximum speed, reaction time, path length, or initial movement are analyzed from the data acquired objectively by the robotic device to evaluate the influence of the task visualization. At the end of the study, a usability survey was provided to each patient to analysis his/her satisfaction level. For all patients, the movement trajectories were enhanced when they completed the therapy. This fact suggests that patient's motor recovery was increased. Despite of the similarity in majority of the kinematic parameters, differences in reaction time and path length were higher using the 3D task. Regarding the success rates

  10. A Comparative Analysis of 2D and 3D Tasks for Virtual Reality Therapies Based on Robotic-Assisted Neurorehabilitation for Post-stroke Patients

    PubMed Central

    Lledó, Luis D.; Díez, Jorge A.; Bertomeu-Motos, Arturo; Ezquerro, Santiago; Badesa, Francisco J.; Sabater-Navarro, José M.; García-Aracil, Nicolás

    2016-01-01

    Post-stroke neurorehabilitation based on virtual therapies are performed completing repetitive exercises shown in visual electronic devices, whose content represents imaginary or daily life tasks. Currently, there are two ways of visualization of these task. 3D virtual environments are used to get a three dimensional space that represents the real world with a high level of detail, whose realism is determinated by the resolucion and fidelity of the objects of the task. Furthermore, 2D virtual environments are used to represent the tasks with a low degree of realism using techniques of bidimensional graphics. However, the type of visualization can influence the quality of perception of the task, affecting the patient's sensorimotor performance. The purpose of this paper was to evaluate if there were differences in patterns of kinematic movements when post-stroke patients performed a reach task viewing a virtual therapeutic game with two different type of visualization of virtual environment: 2D and 3D. Nine post-stroke patients have participated in the study receiving a virtual therapy assisted by PUPArm rehabilitation robot. Horizontal movements of the upper limb were performed to complete the aim of the tasks, which consist in reaching peripheral or perspective targets depending on the virtual environment shown. Various parameter types such as the maximum speed, reaction time, path length, or initial movement are analyzed from the data acquired objectively by the robotic device to evaluate the influence of the task visualization. At the end of the study, a usability survey was provided to each patient to analysis his/her satisfaction level. For all patients, the movement trajectories were enhanced when they completed the therapy. This fact suggests that patient's motor recovery was increased. Despite of the similarity in majority of the kinematic parameters, differences in reaction time and path length were higher using the 3D task. Regarding the success rates

  11. A Benchmarking Analysis for Five Radionuclide Vadose Zone Models (Chain, Multimed{_}DP, Fectuz, Hydrus, and Chain 2D) in Soil Screening Level Calculations

    SciTech Connect

    Chen, J-S.; Drake, R.; Lin, Z.; Jewett, D. G.

    2002-02-26

    Five vadose zone models with different degrees of complexity (CHAIN, MULTIMED{_}DP, FECTUZ, HYDRUS, and CHAIN 2D) were selected for use in radionuclide soil screening level (SSL) calculations. A benchmarking analysis between the models was conducted for a radionuclide ({sup 99}Tc) release scenario at the Las Cruces Trench Site in New Mexico. Sensitivity of three model outputs to the input parameters were evaluated and compared among the models. The three outputs were peak contaminant concentrations, time to peak concentrations at the water table, and time to exceed the contaminants maximum critical level at a representative receptor well. Model parameters investigated include soil properties such as bulk density, water content, soil water retention parameters and hydraulic conductivity. Chemical properties examined include distribution coefficient, radionuclide half-life, dispersion coefficient, and molecular diffusion. Other soil characteristics, such as recharge rate, also were examined. Model sensitivity was quantified in the form of sensitivity and relative sensitivity coefficients. Relative sensitivities were used to compare the sensitivities of different parameters. The analysis indicates that soil water content, recharge rate, saturated soil water content, and soil retention parameter, {beta}, have a great influence on model outputs. In general, the results of sensitivities and relative sensitivities using five models are similar for a specific scenario. Slight differences were observed in predicted peak contaminant concentrations due to different mathematical treatment among models. The results of benchmarking and sensitivity analysis would facilitate the model selection and application of the model in SSL calculations.

  12. Chemical analysis of solid materials by a LIMS instrument designed for space research: 2D elemental imaging, sub-nm depth profiling and molecular surface analysis

    NASA Astrophysics Data System (ADS)

    Moreno-García, Pavel; Grimaudo, Valentine; Riedo, Andreas; Neuland, Maike B.; Tulej, Marek; Broekmann, Peter; Wurz, Peter

    2016-04-01

    Direct quantitative chemical analysis with high lateral and vertical resolution of solid materials is of prime importance for the development of a wide variety of research fields, including e.g., astrobiology, archeology, mineralogy, electronics, among many others. Nowadays, studies carried out by complementary state-of-the-art analytical techniques such as Auger Electron Spectroscopy (AES), X-ray Photoelectron Spectroscopy (XPS), Secondary Ion Mass Spectrometry (SIMS), Glow Discharge Time-of-Flight Mass Spectrometry (GD-TOF-MS) or Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) provide extensive insight into the chemical composition and allow for a deep understanding of processes that might have fashioned the outmost layers of an analyte due to its interaction with the surrounding environment. Nonetheless, these investigations typically employ equipment that is not suitable for implementation on spacecraft, where requirements concerning weight, size and power consumption are very strict. In recent years Laser Ablation/Ionization Mass Spectrometry (LIMS) has re-emerged as a powerful analytical technique suitable not only for laboratory but also for space applications.[1-3] Its improved performance and measurement capabilities result from the use of cutting edge ultra-short femtosecond laser sources, improved vacuum technology and fast electronics. Because of its ultimate compactness, simplicity and robustness it has already proven to be a very suitable analytical tool for elemental and isotope investigations in space research.[4] In this contribution we demonstrate extended capabilities of our LMS instrument by means of three case studies: i) 2D chemical imaging performed on an Allende meteorite sample,[5] ii) depth profiling with unprecedented sub-nm vertical resolution on Cu electrodeposited interconnects[6,7] and iii) preliminary molecular desorption of polymers without assistance of matrix or functionalized substrates.[8] On the whole

  13. Peculiarities of data interpretation upon direct tissue analysis by Fourier transform ion cyclotron resonance mass spectrometry.

    PubMed

    Chagovets, Vtaliy; Kononikhin, Aleksey; Starodubtseva, Nataliia; Kostyukevich, Yury; Popov, Igor; Frankevich, Vladimir; Nikolaev, Eugene

    2016-01-01

    The importance of high-resolution mass spectrometry for the correct data interpretation of a direct tissue analysis is demonstrated with an example of its clinical application for an endometriosis study. Multivariate analysis of the data discovers lipid species differentially expressed in different tissues under investigation. High-resolution mass spectrometry allows unambiguous separation of peaks with close masses that correspond to proton and sodium adducts of phosphatidylcholines and to phosphatidylcholines differing in double bond number. PMID:27553733

  14. Penalized discriminant analysis for the detection of wild-grown and cultivated Ganoderma lucidum using Fourier transform infrared spectroscopy.

    PubMed

    Zhu, Ying; Tan, Tuck Lee

    2016-04-15

    An effective and simple analytical method using Fourier transform infrared (FTIR) spectroscopy to distinguish wild-grown high-quality Ganoderma lucidum (G. lucidum) from cultivated one is of essential importance for its quality assurance and medicinal value estimation. Commonly used chemical and analytical methods using full spectrum are not so effective for the detection and interpretation due to the complex system of the herbal medicine. In this study, two penalized discriminant analysis models, penalized linear discriminant analysis (PLDA) and elastic net (Elnet),using FTIR spectroscopy have been explored for the purpose of discrimination and interpretation. The classification performances of the two penalized models have been compared with two widely used multivariate methods, principal component discriminant analysis (PCDA) and partial least squares discriminant analysis (PLSDA). The Elnet model involving a combination of L1 and L2 norm penalties enabled an automatic selection of a small number of informative spectral absorption bands and gave an excellent classification accuracy of 99% for discrimination between spectra of wild-grown and cultivated G. lucidum. Its classification performance was superior to that of the PLDA model in a pure L1 setting and outperformed the PCDA and PLSDA models using full wavelength. The well-performed selection of informative spectral features leads to substantial reduction in model complexity and improvement of classification accuracy, and it is particularly helpful for the quantitative interpretations of the major chemical constituents of G. lucidum regarding its anti-cancer effects. PMID:26827180

  15. Penalized discriminant analysis for the detection of wild-grown and cultivated Ganoderma lucidum using Fourier transform infrared spectroscopy

    NASA Astrophysics Data System (ADS)

    Zhu, Ying; Tan, Tuck Lee

    2016-04-01

    An effective and simple analytical method using Fourier transform infrared (FTIR) spectroscopy to distinguish wild-grown high-quality Ganoderma lucidum (G. lucidum) from cultivated one is of essential importance for its quality assurance and medicinal value estimation. Commonly used chemical and analytical methods using full spectrum are not so effective for the detection and interpretation due to the complex system of the herbal medicine. In this study, two penalized discriminant analysis models, penalized linear discriminant analysis (PLDA) and elastic net (Elnet),using FTIR spectroscopy have been explored for the purpose of discrimination and interpretation. The classification performances of the two penalized models have been compared with two widely used multivariate methods, principal component discriminant analysis (PCDA) and partial least squares discriminant analysis (PLSDA). The Elnet model involving a combination of L1 and L2 norm penalties enabled an automatic selection of a small number of informative spectral absorption bands and gave an excellent classification accuracy of 99% for discrimination between spectra of wild-grown and cultivated G. lucidum. Its classification performance was superior to that of the PLDA model in a pure L1 setting and outperformed the PCDA and PLSDA models using full wavelength. The well-performed selection of informative spectral features leads to substantial reduction in model complexity and improvement of classification accuracy, and it is particularly helpful for the quantitative interpretations of the major chemical constituents of G. lucidum regarding its anti-cancer effects.

  16. SPHARA - A Generalized Spatial Fourier Analysis for Multi-Sensor Systems with Non-Uniformly Arranged Sensors: Application to EEG

    PubMed Central

    Graichen, Uwe; Eichardt, Roland; Fiedler, Patrique; Strohmeier, Daniel; Zanow, Frank; Haueisen, Jens

    2015-01-01

    Important requirements for the analysis of multichannel EEG data are efficient techniques for signal enhancement, signal decomposition, feature extraction, and dimensionality reduction. We propose a new approach for spatial harmonic analysis (SPHARA) that extends the classical spatial Fourier analysis to EEG sensors positioned non-uniformly on the surface of the head. The proposed method is based on the eigenanalysis of the discrete Laplace-Beltrami operator defined on a triangular mesh. We present several ways to discretize the continuous Laplace-Beltrami operator and compare the properties of the resulting basis functions computed using these discretization methods. We apply SPHARA to somatosensory evoked potential data from eleven volunteers and demonstrate the ability of the method for spatial data decomposition, dimensionality reduction and noise suppression. When employing SPHARA for dimensionality reduction, a significantly more compact representation can be achieved using the FEM approach, compared to the other discretization methods. Using FEM, to recover 95% and 99% of the total energy of the EEG data, on average only 35% and 58% of the coefficients are necessary. The capability of SPHARA for noise suppression is shown using artificial data. We conclude that SPHARA can be used for spatial harmonic analysis of multi-sensor data at arbitrary positions and can be utilized in a variety of other applications. PMID:25885290

  17. Multimode vibration analysis with high-speed TV holography and a spatiotemporal 3D Fourier transform method.

    PubMed

    Trillo, Cristina; Doval, Angel F; Mendoza-Santoyo, Fernando; Pérez-López, Carlos; de la Torre-Ibarra, Manuel; Deán, J Luis

    2009-09-28

    The combination of a high-speed TV holography system and a 3D Fourier-transform data processing is proposed for the analysis of multimode vibrations in plates. The out-of-plane displacement of the object under generic vibrational excitation is resolved in time by the fast acquisition rate of a high-speed camera, and recorded in a sequence of interferograms with spatial carrier. A full-field temporal history of the multimode vibration is thus obtained. The optical phase of the interferograms is extracted and subtracted from the phase of a reference state to yield a sequence of optical phase-change maps. Each map represents the change undergone by the object between any given state and the reference state. The sequence of maps is a 3D array of data (two spatial dimensions plus time) that is processed with a 3D Fourier-transform algorithm. The individual vibration modes are separated in the 3D frequency space due to their different vibration frequencies and, to a lesser extent, to the different spatial frequencies of the mode shapes. The contribution of each individual mode (or indeed the superposition of several modes) to the dynamic behaviour of the object can then be separated by means of a bandpass filter (or filters). The final output is a sequence of complex-valued maps that contain the full-field temporal history of the selected mode (or modes) in terms of its mechanical amplitude and phase. The proof-of-principle of the technique is demonstrated with a rectangular, fully clamped, thin metal plate vibrating simultaneously in several of its natural resonant frequencies under white-noise excitation. PMID:19907591

  18. Characterization of alluvial sources in the Owens Valley of eastern California using Fourier shape analysis

    SciTech Connect

    Wagoner, J.L.; Younker, J.L.

    1982-03-01

    Two-dimensional quartz grain shape was used to characterize sand grains from different source areas in the Owens Valley of eastern California. Combining a mathematical description of the grain outline and multivariate discriminant analysis, we have shown that quartz from clastic source rocks has a distinctive imprint when compared to samples from granitic, volcanic, or mixed fluvial source areas. Alternatively, quartz provided by a granitic source could equally well have been interpreted as if it were derived from any of the other sources considered. This study provides a standard of comparison for further analysis of sediment deposited in arid alluvial environments.

  19. Ultrastructural characterization and Fourier analysis of fiber cell cytoplasm in the hyperbaric oxygen treated guinea pig lens opacification model.

    PubMed

    Freel, Christopher D; Gilliland, Kurt O; Mekeel, Harold E; Giblin, Frank J; Costello, M Joseph

    2003-04-01

    The structural characteristics of differentiated fiber cells in control and hyperbaric oxygen (HBO)-treated guinea pig lenses were examined by transmission electron microscopy (TEM). Emphasis was placed on cell damage, membrane integrity, and cytoplasmic texture. Given the faint gross opacities observed in HBO-treated lenses in previous studies, it was hypothesized that subtle but significant morphological differences due to oxidative damage exist between control and treated animals. Experimental animals received either 70 or 85 treatments with HBO (2.5 atm of 100% O(2) for 2.5 hr, 3 times per week for 5-7 months). All specimens were obtained within 24 hr of death. Freshly cut Vibratome lens sections were fixed and processed for low and high-magnification thin-section TEM analysis. Cytoplasmic texture was analyzed using Fourier and autocorrelation image processing techniques. Low-magnification analysis revealed relatively insignificant differences in general appearance between the fiber cells of the inner fetal and embryonic nuclei in control and HBO-treated guinea pigs. Both groups demonstrated cells of similar morphology with equivalent membrane complexity and homogeneous cytoplasmic texture. Evidence of any major cellular damage or extracellular space debris was not obvious. High-magnification analysis of the cytoplasm of the treated lenses exhibited a mild, yet detectable increase in texture compared with controls and was confirmed by Fourier analysis. Cytoplasmic texture increased in complexity with additional treatments. The absence of major cellular damage in the lenses of HBO-treated animals suggests a less conspicuous source of light scattering. The small changes in cytoplasmic organization observed between treated and control animals may entirely account for the increase in nuclear light scattering observed by slit lamp. The results obtained with this guinea pig/HBO model parallel many of the morphological data associated with human nuclear cataracts. The

  20. A rapid method to screen for cell-wall mutants using discriminant analysis of Fourier transform infrared spectra.

    PubMed

    Chen, L; Carpita, N C; Reiter, W D; Wilson, R H; Jeffries, C; McCann, M C

    1998-11-01

    We have developed a rapid method to screen large numbers of mutant plants for a broad range of cell wall phenotypes using Fourier transform infrared (FTIR) microspectroscopy of leaves. We established and validated a model that can discriminate between the leaves of wild-type and a previously defined set of cell-wall mutants of Arabidopsis. Exploratory principal component analysis indicated that mutants deficient in different cell-wall sugars can be distinguished from each other. Discrimination of cell-wall mutants from wild-type was independent of variability in starch content or additional unrelated mutations that might be present in a heavily mutagenised population. We then developed an analysis of FTIR spectra of leaves obtained from over 1000 mutagenised flax plants, and selected 59 plants whose spectral variation from wild-type was significantly out of the range of a wild-type population, determined by Mahalanobis distance. Cell wall sugars from the leaves of selected putative mutants were assayed by gas chromatography-mass spectrometry and 42 showed significant differences in neutral sugar composition. The FTIR spectra indicated that six of the remaining 17 plants have altered ester or protein content. We conclude that linear discriminant analysis of FTIR spectra is a robust method to identify a broad range of structural and architectural alterations in cell walls, appearing as a consequence of developmental regulation, environmental adaptation or genetic modification. PMID:9881159

  1. Numerous applications of fiber optic evanescent wave Fourier transform infrared (FEW-FTIR) spectroscopy for subsurface structural analysis

    NASA Astrophysics Data System (ADS)

    Afanasyeva, Natalia I.; Welser, Leslie; Bruch, Reinhard F.; Kano, Angelique; Makhine, Volodymyr

    1999-10-01

    A new infrared (IR) interferometric method has been developed in conjunction with low-loss, flexible optical fibers, sensors, and probes. This combination of fiber optical sensors and Fourier Transform (FT) spectrometers can be applied to many fields, including (1) noninvasive medical diagnostics of cancer and other different diseases in vivo, (2) minimally invasive bulk diagnostics of tissue, (3) remote monitoring of tissue, chemical processes, and environment, (4) surface analysis of polymers and other materials, (5) characterization of the quality of food, pharmacological products, cosmetics, paper, and other wood-related products, as well as (6) agricultural, forensic, geological, mining, and archeological field measurements. In particular, our nondestructive, fast, compact, portable, remote and highly sensitive diagnostics tools are very promising for subsurface analysis at the molecular level without sample preparation. For example, this technique is ideal for different types of soft porous foams, rough polymers, and rock surfaces. Such surfaces, as well as living tissue, are very difficult to investigate by traditional FTIR methods. We present here FEW-FTIR spectra of polymers, banana and grapefruit peels, and living tissues detected directly at surfaces. In addition, results on the vibrational spectral analysis of normal and pathological skin tissue in the region of 850 - 4000 cm-1 are discussed.

  2. Texture Analysis of the Epidermis Based on Fast Fourier Transformation in Sjögren-Larsson Syndrome

    PubMed Central

    Auada, Mariam P; Adam, Randall L.; Leite, Neucimar J.; Puzzi, Maria B.; Cintra, Maria L.; Rizzo, William B.; Metze, Konradin

    2011-01-01

    OBJECTIVE To investigate whether image analysis of routine hematoxylin-eosin (H-E) skin sections usingfast Fourier transformation (FFT) could detect structural alterations in patients with Sjögren-Larsson syndrome (SLS) diagnosed by molecular biology. STUDY DESIGN Skin punch biopsies of 9 patients with SLS and 17 healthy volunteers were obtained. Digital images of routine histologic sections were taken, and their gray scale luminance was analyzed by FFT. The inertia values were determined for different ranges of the spatial frequencies in the vertical and horizontal direction. To get an estimation of anisotropy, we calculated the resultant vector of the designated frequency ranges. RESULTS In the prickle cell layer, SLS patients showed more intense amplitudes in spatial structures with periods between 1.2 and 3.6 µm in the vertical direction, which correlated in part with accentuated nuclei and nucleoli and perinucleolar halos in the H-E sections. In a linear discriminant analysis, the variables derived from the FFT images correctly discriminated 84.6% of the patients. Texture features derived from the gray level co-occurrence matrix were not able to separate the groups. CONCLUSION Exploratory texture analysis by FFT was able to detect discrete alterations in the prickle cell layer in routine light microscopy slides of SLS patients. The structural changes identified by FFT may be related to abnormal cellular components associated with aberrant lipid metabolism. PMID:16927642

  3. A 2D-DIGE-based proteomic analysis reveals differences in the platelet releasate composition when comparing thrombin and collagen stimulations

    PubMed Central

    Vélez, Paula; Izquierdo, Irene; Rosa, Isaac; García, Ángel

    2015-01-01

    Upon stimulation, platelets release a high number of proteins (the releasate). There are clear indications that these proteins are involved in the pathogenesis of several diseases, such as atherosclerosis. In the present study we compared the platelet releasate following platelet activation with two major endogenous agonists: thrombin and collagen. Proteome analysis was based on 2D-DIGE and LC-MS/MS. Firstly, we showed the primary role of thrombin and collagen receptors in platelet secretion by these agonists; moreover, we demonstrated that GPVI is the primary responsible for collagen-induced platelet activation/aggregation. Proteomic analysis allowed the detection of 122 protein spots differentially regulated between both conditions. After excluding fibrinogen spots, down-regulated in the releasate of thrombin-activated platelets, 84 differences remained. From those, we successfully identified 42, corresponding to 37 open-reading frames. Many of the differences identified correspond to post-translational modifications, primarily, proteolysis induced by thrombin. Among others, we show vitamin K-dependent protein S, an anticoagulant plasma protein, is up-regulated in thrombin samples. Our results could have pathological implications given that platelets might be playing a differential role in various diseases and biological processes through the secretion of different subsets of granule proteins and microvesicles following a predominant activation of certain receptors. PMID:25645904

  4. Applications of the computer codes FLUX2D and PHI3D for the electromagnetic analysis of compressed magnetic field generators and power flow channels

    SciTech Connect

    Hodgdon, M.L.; Oona, H.; Martinez, A.R.; Salon, S.; Wendling, P.; Krahenbuhl, L.; Nicolas, A.; Nicolas, L.

    1989-01-01

    We present herein the results of three electromagnetic field problems for compressed magnetic field generators and their associated power flow channels. The first problem is the computation of the transient magnetic field in a two-dimensional model of helical generator during loading. The second problem is the three-dimensional eddy current patterns in a section of an armature beneath a bifurcation point of a helical winding. Our third problem is the calculation of the three-dimensional electrostatic fields in a region known as the post-hole convolute in which a rod connects the inner and outer walls of a system of three concentric cylinders through a hole in the middle cylinder. While analytic solutions exist for many electromagnetic field problems in cases of special and ideal geometries, the solutions of these and similar problems for the proper analysis and design of compressed magnetic field generators and their related hardware require computer simulations. In earlier studies, computer models have been proposed, several based on research oriented hydrocodes to which uncoupled or partially coupled Maxwell's equations solvers are added. Although the hydrocode models address the problem of moving, deformable conductors, they are not useful for electromagnetic analysis, nor can they be considered design tools. For our studies, we take advantage of the commercial, electromagnetic computer-aided design software packages FLUX2D nd PHI3D that were developed for motor manufacturers and utilities industries. 4 refs., 6 figs.

  5. VIBA-Lab 3.0: Computer program for simulation and semi-quantitative analysis of PIXE and RBS spectra and 2D elemental maps

    NASA Astrophysics Data System (ADS)

    Orlić, Ivica; Mekterović, Darko; Mekterović, Igor; Ivošević, Tatjana

    2015-11-01

    VIBA-Lab is a computer program originally developed by the author and co-workers at the National University of Singapore (NUS) as an interactive software package for simulation of Particle Induced X-ray Emission and Rutherford Backscattering Spectra. The original program is redeveloped to a VIBA-Lab 3.0 in which the user can perform semi-quantitative analysis by comparing simulated and measured spectra as well as simulate 2D elemental maps for a given 3D sample composition. The latest version has a new and more versatile user interface. It also has the latest data set of fundamental parameters such as Coster-Kronig transition rates, fluorescence yields, mass absorption coefficients and ionization cross sections for K and L lines in a wider energy range than the original program. Our short-term plan is to introduce routine for quantitative analysis for multiple PIXE and XRF excitations. VIBA-Lab is an excellent teaching tool for students and researchers in using PIXE and RBS techniques. At the same time the program helps when planning an experiment and when optimizing experimental parameters such as incident ions, their energy, detector specifications, filters, geometry, etc. By "running" a virtual experiment the user can test various scenarios until the optimal PIXE and BS spectra are obtained and in this way save a lot of expensive machine time.

  6. Distinct metabolic changes between wheat embryo and endosperm during grain development revealed by 2D-DIGE-based integrative proteome analysis.

    PubMed

    Cao, Hui; He, Miao; Zhu, Chong; Yuan, Linlin; Dong, Liwei; Bian, Yanwei; Zhang, Wenying; Yan, Yueming

    2016-05-01

    Two Chinese bread wheat cultivars, Jinghua 9 and Zhongmai 175, distinct in grain weight and dough quality, were used to study proteome changes in the embryo and endosperm during grain development using a two-dimensional difference gel electrophoresis (2D-DIGE)-based proteomics approach. In total, 138 and 127 differentially expressed protein (DEP) spots representing 116 and 113 unique DEPs were identified in the embryo and endosperm, respectively. Among them, 54 (31%) DEPs were commonly present in both organs while 62 (35%) and 59 (34%) DEPs occurred only in the embryo and endosperm, respectively. Embryonic DEPs are primarily stress-related proteins and involved in carbohydrate and lipid metabolism, while those from the endosperm are related primarily to carbohydrate metabolism and storage. Principal component analysis (PCA) indicated that the proteome differences in the endosperm caused by different cultivars were greater than those by development stages, while the differences in the embryo showed the opposite pattern. Protein-protein interaction (PPI) analysis revealed a complex network centered primarily on enzymes involved in carbohydrate and protein metabolism. The transcriptional levels of fourteen important DEPs encoding genes showed high similarity between organs and cultivars. In particular, some key DEPs of the endosperm, such as phosphoglucomutase, ADP-glucose pyrophosphorylase (AGPase), and sucrose synthase (SUS), showed significantly upregulated expression, indicating their key roles in starch biosynthesis and grain yield. Moreover, upregulated expression of some storage proteins in the endosperm could improve wheat bread-making quality. PMID:26968330

  7. Proteomic analysis by two-dimensional differential in gel electrophoresis (2D DIGE) of the early response of Pisum sativum to Orobanche crenata.

    PubMed

    Castillejo, Ma Ángeles; Fernández-Aparicio, Mónica; Rubiales, Diego

    2012-01-01

    Crenate broomrape (Orobanche crenata) is considered to be the major constraint for legume crops in Mediterranean countries. Strategies of control have been developed, but only marginal successes have been achieved. For the efficient control of the parasite, a better understanding of its interaction and associated resistance mechanisms at the molecular level is required. The pea response to this parasitic plant and the molecular basis of the resistance was studied using a proteomic approach based on 2D DIGE and MALDI-MSMS analysis. For this purpose, two genotypes showing different levels of resistance to O. crenata, as well as three time points (21, 25, and 30 d after inoculation) have been compared. Multivariate statistical analysis identified 43 differential protein spots under the experimental conditions (genotypes/treatments), 22 of which were identified using a combination of peptide mass fingerprinting (PMF) and MSMS fragmentation. Most of the proteins identified were metabolic and stress-related proteins and a high percentage of them (86%) matched with specific proteins of legume species. The behaviour pattern of the identified proteins suggests the existence of defence mechanisms operating during the early stages of infection that differed in both genotypes. Among these, several proteins were identified with protease activity which could play an important role in preventing the penetration and connection to the vascular system of the parasite. Our data are discussed and compared with those previously obtained in pea and Medicago truncatula. PMID:21920908

  8. Kolmogorov-Smirnov like test for time-frequency Fourier spectrogram analysis in LISA Pathfinder

    NASA Astrophysics Data System (ADS)

    Ferraioli, Luigi; Armano, Michele; Audley, Heather; Congedo, Giuseppe; Diepholz, Ingo; Gibert, Ferran; Hewitson, Martin; Hueller, Mauro; Karnesis, Nikolaos; Korsakova, Natalia; Nofrarias, Miquel; Plagnol, Eric; Vitale, Stefano

    2015-03-01

    A statistical procedure for the analysis of time-frequency noise maps is presented and applied to LISA Pathfinder mission synthetic data. The procedure is based on the Kolmogorov-Smirnov like test that is applied to the analysis of time-frequency noise maps produced with the spectrogram technique. The influence of the finite size windowing on the statistic of the test is calculated with a Monte Carlo simulation for 4 different windows type. Such calculation demonstrate that the test statistic is modified by the correlations introduced in the spectrum by the finite size of the window and by the correlations between different time bins originated by overlapping between windowed segments. The application of the test procedure to LISA Pathfinder data demonstrates the test capability of detecting non-stationary features in a noise time series that is simulating low frequency non-stationary noise in the system.

  9. Mass Spectrometry and Fourier Transform Infrared Spectroscopy for Analysis of Biological Materials

    SciTech Connect

    Anderson, Timothy J.

    2014-12-01

    Time-of-flight mass spectrometry along with statistical analysis was utilized to study metabolic profiles among rats fed resistant starch (RS) diets. Fischer 344 rats were fed four starch diets consisting of 55% (w/w, dbs) starch. A control starch diet consisting of corn starch was compared against three RS diets. The RS diets were high-amylose corn starch (HA7), HA7 chemically modified with octenyl succinic anhydride, and stearic-acid-complexed HA7 starch. A subgroup received antibiotic treatment to determine if perturbations in the gut microbiome were long lasting. A second subgroup was treated with azoxymethane (AOM), a carcinogen. At the end of the eight week study, cecal and distal-colon contents samples were collected from the sacrificed rats. Metabolites were extracted from cecal and distal colon samples into acetonitrile. The extracts were then analyzed on an accurate-mass time-of-flight mass spectrometer to obtain their metabolic profile. The data were analyzed using partial least-squares discriminant analysis (PLS-DA). The PLS-DA analysis utilized a training set and verification set to classify samples within diet and treatment groups. PLS-DA could reliably differentiate the diet treatments for both cecal and distal colon samples. The PLS-DA analyses of the antibiotic and no antibiotic treated subgroups were well classified for cecal samples and modestly separated for distal-colon samples. PLS-DA analysis had limited success separating distal colon samples for rats given AOM from those not treated; the cecal samples from AOM had very poor classification. Mass spectrometry profiling coupled with PLS-DA can readily classify metabolite differences among rats given RS diets.

  10. Analysis of the nutritional status of algae by Fourier transform infrared chemical imaging

    NASA Astrophysics Data System (ADS)

    Hirschmugl, Carol J.; Bayarri, Zuheir-El; Bunta, Maria; Holt, Justin B.; Giordano, Mario

    2006-09-01

    A new non-destructive method to study the nutritional status of algal cells and their environments is demonstrated. This approach allows rapid examination of whole cells without any or little pre-treatment providing a large amount of information on the biochemical composition of cells and growth medium. The method is based on the analysis of a collection of infrared (IR) spectra for individual cells; each spectrum describes the biochemical composition of a portion of a cell; a complete set of spectra is used to reconstruct an image of the entire cell. To obtain spatially resolved information synchrotron radiation was used as a bright IR source. We tested this method on the green flagellate Euglena gracilis; a comparison was conducted between cells grown in nutrient replete conditions (Type 1) and on cells allowed to deplete their medium (Type 2). Complete sets of spectra for individual cells of both types were analyzed with agglomerative hierarchical clustering, leading to distinct clusters representative of the two types of cells. The average spectra for the clusters confirmed the similarities between the clusters and the types of cells. The clustering analysis, therefore, allows the distinction of cells of the same species, but with different nutritional histories. In order to facilitate the application of the method and reduce manipulation (washing), we analyzed the cells in the presence of residual medium. The results obtained showed that even with residual medium the outcome of the clustering analysis is reliable. Our results demonstrate the applicability FTIR microspectroscopy for ecological and ecophysiological studies.

  11. Seismic response analysis of a tuff cliff by an effective stress non-linear 2D model approach: an example in Sorrento Peninsula, Italy

    NASA Astrophysics Data System (ADS)

    di Fiore, V.; Angelino, A.; Buonocunto, F. P.; Rapolla, A.; Tarallo, D.

    2009-04-01

    We present a model to describe the behavior of a tuff cliff under the dynamic stress considering a law reference input motion. The studied area is located in the Sorrento Peninsula, a major Quaternary morpho-structural unit of the western flank of Southern Apennines. The peninsula forms a narrow and elevated mountain range (up to 1444 m) that separates two major embayments of the eastern Tyrrhenian margin and is characterized by a carbonate bedrock capped by pyroclastic deposits (i.e. "Campania Ignimbrite"), originated from the Campi Flegrei volcanic district. The occurrence of steep slopes and the high relief energy of the area, along with the marine erosion at the base of the coastal cliff creates favorable conditions for the occurrence of a generalized instability of the slopes that is manifested by tuff rock falls as prevailing landslide phenomena. These events are highly dangerous because of the sudden detachments of conspicuous volumes of rocks with high speed, especially when the rock fall initiates in the upper part of the slopes. Prediction of such landslides is difficult if not accompanied by accurate hydrogeologic and geotechnical monitoring and assessment. The geometry of our model is represented by a tuff cliff of 48 m height, covered by a 8 m thick volcaniclastic layer. At the base of the tuff cliff marine sand deposits occur. The geotechnical parameters used for the analysis were selected from the literature. We have used an effective stress non-linear 2D model to determine the dynamic stress field of our model. The effective stress non-linear algorithm uses the Direct Integration Method to compute the motion and excess pore-water pressures arising from inertial forces at user-defined time steps. The seismic response analysis was performed using the field shear stress generated by synthetic 1-30 Hz band-limited accelerogram. The finite elements mesh considered for the test problem was established by 395 element and 401 nodal point. Our results show a

  12. Internal Photoemission Spectroscopy of 2-D Materials

    NASA Astrophysics Data System (ADS)

    Nguyen, Nhan; Li, Mingda; Vishwanath, Suresh; Yan, Rusen; Xiao, Shudong; Xing, Huili; Cheng, Guangjun; Hight Walker, Angela; Zhang, Qin

    Recent research has shown the great benefits of using 2-D materials in the tunnel field-effect transistor (TFET), which is considered a promising candidate for the beyond-CMOS technology. The on-state current of TFET can be enhanced by engineering the band alignment of different 2D-2D or 2D-3D heterostructures. Here we present the internal photoemission spectroscopy (IPE) approach to determine the band alignments of various 2-D materials, in particular SnSe2 and WSe2, which have been proposed for new TFET designs. The metal-oxide-2-D semiconductor test structures are fabricated and characterized by IPE, where the band offsets from the 2-D semiconductor to the oxide conduction band minimum are determined by the threshold of the cube root of IPE yields as a function of photon energy. In particular, we find that SnSe2 has a larger electron affinity than most semiconductors and can be combined with other semiconductors to form near broken-gap heterojunctions with low barrier heights which can produce a higher on-state current. The details of data analysis of IPE and the results from Raman spectroscopy and spectroscopic ellipsometry measurements will also be presented and discussed.

  13. Global molecular genetic analysis of porcine circovirus type 2 (PCV2) sequences confirms the presence of four main PCV2 genotypes and reveals a rapid increase of PCV2d.

    PubMed

    Xiao, Chao-Ting; Halbur, Patrick G; Opriessnig, Tanja

    2015-07-01

    The oldest porcine circovirus type 2 (PCV2) sequence dates back to 1962 and is among several hundreds of publicly available PCV2 sequences. Despite this resource, few studies have investigated the global genetic diversity of PCV2. To evaluate the phylogenetic relationship of PCV2 strains, 1680 PCV2 open reading frame 2 (ORF2) sequences were compared and analysed by methods of neighbour-joining, maximum-likelihood, Bayesian inference and network analysis. Four distinct clades were consistently identified and included PCV2a, PCV2b, PCV2c and PCV2d; the p-distance between PCV2d and PCV2b was 0.055±0.008, larger than the PCV2 genotype-definition cut-off of 0.035, supporting PCV2d as an independent genotype. Among the 1680 sequences, 278-285 (16.5-17 %) were classified as PCV2a, 1007-1058 (59.9-63 %) as PCV2b, three (0.2 %) as PCV2c and 322-323 (19.2 %) as PCV2d, with the remaining 12-78 sequences (0.7-4.6 %) classified as intermediate clades or strains by the various methods. Classification of strains to genotypes differed based on the number of sequences used for the analysis, indicating that sample size is important when determining classification and assessing PCV2 trends and shifts. PCV2d was initially identified in 1999 in samples collected in Switzerland, now appears to be widespread in China and has been present in North America since 2012. During 2012-2013, 37 % of all investigated PCV2 sequences from US pigs were classified as PCV2d and overall data analysis suggests an ongoing genotype shift from PCV2b towards PCV2d. The present analyses indicate that PCV2d emerged approximately 20 years ago. PMID:25711965

  14. Analysis of saturated hydrocarbons by redox reaction with negative-ion electrospray Fourier transform ion cyclotron resonance mass spectrometry.

    PubMed

    Zhou, Xibin; Shi, Quan; Zhang, Yahe; Zhao, Suoqi; Zhang, Rui; Chung, Keng H; Xu, Chunming

    2012-04-01

    A novel technique was developed for characterization of saturated hydrocarbons. Linear alkanes were selectively oxidized to ketones by ruthenium ion catalyzed oxidation (RICO). Branched and cyclic alkanes were oxidized to alcohols and ketones. The ketones were then reduced to alcohols by lithium aluminum hydride (LiAlH(4)). The monohydric alcohols (O(1)) in the products obtained from the RICO and RICO-LiAlH(4) reduction reactions were characterized using negative-ion electrospray ionization (ESI) Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) for identification of iso-paraffins, acyclic paraffins and cyclic paraffins. Various model saturated compounds were used to determine the RICO reaction and ionization selectivity. The results from the FTICR MS analysis on the petroleum distillates derived saturated fraction were in agreement with those from field ionization gas chromatography time-of-flight mass spectrometry (FI GC-TOF MS) analysis. The technique was also used to characterize a petroleum vacuum residue (VR) derived saturates. The results showed that the saturated molecules in the VR contained up to 11 cyclic rings, and the maximum carbon number was up to 92. PMID:22424498

  15. Top-Down Analysis of Highly Post-Translationally Modified Peptides by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

    NASA Astrophysics Data System (ADS)

    Guerrero, Andres; Lerno, Larry; Barile, Daniela; Lebrilla, Carlito B.

    2015-03-01

    Bovine κ-caseinoglycomacropeptide (GMP) is a highly modified peptide from κ-casein produced during the cheese making process. The chemical nature of GMP makes analysis by traditional proteomic approaches difficult, as the peptide bears a strong net negative charge and a variety of post-translational modifications. In this work, we describe the use of electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR MS) for the top-down analysis of GMP. The method allows the simultaneous detection of different GMP forms that result from the combination of amino acid genetic variations and post-translational modifications, specifically phosphorylation and O-glycosylation. The different GMP forms were identified by high resolution mass spectrometry in both negative and positive mode and confirmation was achieved by tandem MS. The results showed the predominance of two genetic variants of GMP that occur as either mono- or bi-phosphorylated species. Additionally, these four forms can be modified with up to two O-glycans generally sialylated. The results demonstrate the presence of glycosylated, bi-phosphorylated forms of GMP never described before.

  16. Feasibility of analysis of polar compounds by high performance liquid chromatography with Fourier transform infrared spectroscopic detection

    SciTech Connect

    Amateis, P.G.

    1984-01-01

    High performance liquid chromatographic separations employing on-line flow cell Fourier transform infrared spectroscopic detection were developed for polar compounds including phenols, alcohols, amines and azaarenes. Detection by FTIR gave information concerning hydrogen bonding and solvent effects occurring during the separations in addition to giving structural information about eluted species to aid in identification. Both analytical size and microbore normal phase columns were employed. Such experimental considerations as column overload, injected minimum detectable quantities, the use of analytical vs. microbore columns and flow cell pathlength were examined. The developed HPLC-FTIR systems were applied to the analysis of several coal liquefaction samples for heteroatom content. Confirmatory and additional information concerning the samples were provided by field ionization mass spectrometry, gas chromatography/mass spectrometry and reversed phase liquid chromatography employing UV detection. An equation relating reversed phase retention times to structural parameters was developed and applied to the analysis of the coal-derived samples. Two process solvents were found to contain primarily alkyl-substituted phenols in addition to azaarenes such as pyridine and quinoline. Some non-distillable coal-derived samples were found to contain azaarenes such as alkyl quinolines. Evidence was also found concerning the presence of hydroxy-pyridine type compounds and the incorporation of process solvent molecules into the coal structure during liquefaction.

  17. The use of Fourier transform (FT) surface-enhanced Raman scattering for biochemical analysis

    NASA Astrophysics Data System (ADS)

    Jeffers, Robert Butler

    Surface-enhanced Raman scattering (SERS) is a powerful spectroscopic technique that has created exciting opportunities in the field of bioanalytical chemistry, where it combines ultrasensitive detection of biologically relevant molecules with vibrational spectroscopy. Due to the difficulties in preparing reproducible SERS active substrates, SERS has been mainly used as a qualitative tool. In order for SERS to be utilized as a viable tool for quantitative analysis, simple, facile SERS substrates which generate clean, highly reproducible signals must be developed. This dissertation deals with the evaluation of three different methods of SERS that led to the development of a novel substrate for the analysis of biological molecules. In this dissertation, I demonstrated the generation of a SERS signal from pyridine adsorbed to the surface of a roughened silver electrode. The Raman signal was detected utilizing a remote fiber optic probe dispersive Raman instrument. The necessary parameters for generating the optimal SERS signal were established. The SERS spectrum of pyridine was successfully characterized. The synthesis of silver colloid solutions for use as a SERS active substrate was demonstrated. Two different synthetic methods were utilized and the conditions for optimal SERS signal strength were established. SERS signals from solutions of tryptophan were successfully generated and detected using an FT-Raman spectrometer. In this dissertation. I report the successful chemical deposition of a thin silver film on the surface of a quartz/glass fiber filter for use as a SERS active substrate. The successful detection of the SERS signal of solutions of phenylalanine and tryptophan utilizing the silver-coated filters and a FT-Raman instrument was demonstrated. Significant progress was made to develop a quantifiable SERS method utilizing the silver-coated filters. The silver-coated filter SERS method presented here is a novel and promising method for biochemical analysis

  18. Polyimide analysis using diffuse reflectance-FTIR. [Fourier Transform IR Spectroscopy

    NASA Technical Reports Server (NTRS)

    Young, P. R.; Chang, A. C.

    1985-01-01

    The thermal imidization of a number of polyimide precursors in the form of powders, films, and prepregs was examined by an in situ diffuse reflectance-FTIR technique where infrared spectra were determined while the material was being heated. An analysis of these spectra revealed that, with the exception of one water soluble adhesive, each precursor developed an anhydride band around 1850 cm/cu during imidization. This band diminished in intensity during final stages of cure. Efforts were made to quantify the amount of anhydride in several samples. Evidence obtained could be interpreted to mean that poly(amic acid) resins undergo an initial reduction in molecular weight during imidization before recombining to achieve their ultimate molecular weights as polyimides. Several reports in the literature are cited to support this interpretation. This report serves both to document anhydride formation during imidization and to increase our fundamental understanding of how polyimides cure.

  19. Fourier emission infrared microspectrophotometer for surface analysis. I - Application to lubrication problems

    NASA Technical Reports Server (NTRS)

    Lauer, J. L.; King, V. W.

    1979-01-01

    A far-infrared interferometer was converted into an emission microspectrophotometer for surface analysis. To cover the mid-infrared as well as the far-infrared the Mylar beamsplitter was made replaceable by a germanium-coated salt plate, and the Moire fringe counting system used to locate the moveable Michelson mirror was improved to read 0.5 micron of mirror displacement. Digital electronics and a dedicated minicomputer were installed for data collection and processing. The most critical element for the recording of weak emission spectra from small areas was, however, a reflecting microscope objective and phase-locked signal detection with simultaneous referencing to a blackbody source. An application of the technique to lubrication problems is shown.

  20. Fourier Series Applications in Multitemporal Remote Sensing Analysis using Landsat Data

    NASA Astrophysics Data System (ADS)

    Brooks, Evan Beren

    Researchers now have unprecedented access to free Landsat data, enabling detailed monitoring of the Earth's land surface and vegetation. There are gaps in the data, due in part to cloud cover. The gaps are aperiodic and localized, forcing any detailed multitemporal analysis based on Landsat data to compensate. Harmonic regression approximates Landsat data for any point in time with minimal training images and reduced storage requirements. In two study areas in North Carolina, USA, harmonic regression approaches were least as good at simulating missing data as STAR-FM for images from 2001. Harmonic regression had an R2 ≥ 0.9 over three quarters of all pixels. It gave the highest R2predicted values on two thirds of the pixels. Applying harmonic regression with the same number of harmonics to consecutive years yielded an improved fit, R2 ≥ 0.99 for most pixels. We next demonstrate a change detection method based on exponentially weighted moving average (EWMA) charts of harmonic residuals. In the process, a data-driven cloud filter is created, enabling use of partially clouded data. The approach is shown capable of detecting thins and subtle forest degradations in Alabama, USA, considerably finer than the Landsat spatial resolution in an on-the-fly fashion, with new images easily incorporated into the algorithm. EWMA detection accurately showed the location, timing, and magnitude of 85% of known harvests in the study area, verified by aerial imagery. We use harmonic regression to improve the precision of dynamic forest parameter estimates, generating a robust time series of vegetation index values. These values are classified into strata maps in Alabama, USA, depicting regions of similar growth potential. These maps are applied to Forest Service Forest Inventory and Analysis (FIA) plots, generating post-stratified estimates of static and dynamic forest parameters. Improvements to efficiency for all parameters were such that a comparable random sample would require

  1. Comparative 2D-DIGE proteomic analysis of bovine mammary epithelial cells during lactation reveals protein signatures for lactation persistency and milk yield.

    PubMed

    Janjanam, Jagadeesh; Singh, Surender; Jena, Manoj K; Varshney, Nishant; Kola, Srujana; Kumar, Sudarshan; Kaushik, Jai K; Grover, Sunita; Dang, Ajay K; Mukesh, Manishi; Prakash, B S; Mohanty, Ashok K

    2014-01-01

    Mammary gland is made up of a branching network of ducts that end with alveoli which surrounds the lumen. These alveolar mammary epithelial cells (MEC) reflect the milk producing ability of farm animals. In this study, we have used 2D-DIGE and mass spectrometry to identify the protein changes in MEC during immediate early, peak and late stages of lactation and also compared differentially expressed proteins in MEC isolated from milk of high and low milk producing cows. We have identified 41 differentially expressed proteins during lactation stages and 22 proteins in high and low milk yielding cows. Bioinformatics analysis showed that a majority of the differentially expressed proteins are associated in metabolic process, catalytic and binding activity. The differentially expressed proteins were mapped to the available biological pathways and networks involved in lactation. The proteins up-regulated during late stage of lactation are associated with NF-κB stress induced signaling pathways and whereas Akt, PI3K and p38/MAPK signaling pathways are associated with high milk production mediated through insulin hormone signaling. PMID:25111801

  2. Comparative 2D-DIGE Proteomic Analysis of Bovine Mammary Epithelial Cells during Lactation Reveals Protein Signatures for Lactation Persistency and Milk Yield

    PubMed Central

    Janjanam, Jagadeesh; Singh, Surender; Jena, Manoj K.; Varshney, Nishant; Kola, Srujana; Kumar, Sudarshan; Kaushik, Jai K.; Grover, Sunita; Dang, Ajay K.; Mukesh, Manishi; Prakash, B. S.; Mohanty, Ashok K.

    2014-01-01

    Mammary gland is made up of a branching network of ducts that end with alveoli which surrounds the lumen. These alveolar mammary epithelial cells (MEC) reflect the milk producing ability of farm animals. In this study, we have used 2D-DIGE and mass spectrometry to identify the protein changes in MEC during immediate early, peak and late stages of lactation and also compared differentially expressed proteins in MEC isolated from milk of high and low milk producing cows. We have identified 41 differentially expressed proteins during lactation stages and 22 proteins in high and low milk yielding cows. Bioinformatics analysis showed that a majority of the differentially expressed proteins are associated in metabolic process, catalytic and binding activity. The differentially expressed proteins were mapped to the available biological pathways and networks involved in lactation. The proteins up-regulated during late stage of lactation are associated with NF-κB stress induced signaling pathways and whereas Akt, PI3K and p38/MAPK signaling pathways are associated with high milk production mediated through insulin hormone signaling. PMID:25111801

  3. A novel phosphoprotein analysis scheme for assessing changes in premalignant and malignant breast cell lines using 2D liquid separations, protein microarrays and tandem mass spectrometry

    PubMed Central

    Patwa, Tasneem H.; Wang, Yanfei; Miller, Fred R.; Goodison, Steve; Pennathur, Subramaniam; Barder, Timothy J.; Lubman, David M.

    2008-01-01

    An analysis of phosphorylation changes that occur during cancer progression would provide insights into the molecular pathways responsible for a malignant phenotype. In this study we employed a novel coupling of 2D-liquid separations and protein microarray technology to reveal changes in phosphoprotein status between premalignant (AT1) and malignant (CA1a) cell lines derived from the human MCF10A breast cell lines. Intact proteins were first separated according to their isoelectric point and hydrophobicities, then arrayed on SuperAmine glass slides. Phosphoproteins were detected using the universal, inorganic phospho-sensor dye, ProQ Diamond. Using this dye, out of 140 spots that were positive for phosphorylation, a total of 85 differentially expressed spots were detected over a pH range of 7.2 to 4.0. Proteins were identified and their peptides sequenced by mass spectrometry. The strategy enabled the identification of 75 differentially expressed phosphoproteins, from which 51 phosphorylation sites in 27 unique proteins were confirmed. Interestingly, the majority of differentially expressed phosphorylated proteins observed were nuclear proteins. Three regulators of apoptosis, Bad, Bax and Acinus, were also differentially phosphorylated in the two cell lines. Further development of this strategy will facilitate an understanding of the mechanisms involved in malignancy progression and other disease-related phenotypes. PMID:19194518

  4. Large-scale flooding analysis in the suburbs of Tokyo Metropolis caused by levee breach of the Tone River using a 2D hydrodynamic model.

    PubMed

    Hai, Pham T; Magome, J; Yorozuya, A; Inomata, H; Fukami, K; Takeuchi, K

    2010-01-01

    In order to assess the effects of climate change on flood disasters in urban areas, we applied a two dimensional finite element hydrodynamic model (2D-FEM) to simulate flood processes for the case analysis of levee breach caused by Kathleen Typhoon on 16 September 1947 in Kurihashi reach of Tone River, upstream of Tokyo area. The purpose is to use the model to simulate flood inundation processes under the present topography and land-use conditions with impending extreme flood scenarios due to climate change for mega-urban areas like Tokyo. Simulation used 100 m resolution topographic data (in PWRI), which was derived from original LiDAR (Light Detection and Ranging) data, and levee breach hydrographic data in 1947. In this paper, we will describe the application of the model with calibration approach and techniques when applying for such fine spatial resolution in urban environments. The fine unstructured triangular FEM mesh of the model appeared to be the most capable of introducing of constructions like roads/levees in simulations. Model results can be used to generate flood mapping, subsequently uploaded to Google Earth interface, making the modeling and presentation process much comprehensible to the general public. PMID:20962401

  5. Attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopic analysis of regenerated bone

    NASA Astrophysics Data System (ADS)

    Benetti, Carolina; Kazarain, Sergei G.; Alves, Marco A. V.; Blay, Alberto; Correa, Luciana; Zezell, Denise M.

    2014-03-01

    The cutting of bone is routinely required in medical procedures, especially in dental applications. In such cases, bone regeneration and new bone quality can determine the success of the treatment. This study investigated the main spectral differences of undamaged and healed bone using the ATR-FTIR spectroscopy technique. Three rabbits were submitted to a surgical procedure; a small piece of bone (3x3 mm2) was removed from both sides of their jaws using a high speed drill. After 15 days, the rabbits were euthanized and the jaws were removed. A bone slice was cut from each side of the jaw containing regions of undamaged and newly formed bone, resulting in six samples which were polished for spectroscopic comparison. The samples were analyzed by FTIR spectroscopy using a diamond ATR accessory. Spectral characteristics were compared and particular attention was paid to the proportion of phosphate to amide I bands and the width of the phosphate band. The results show that the ratio of phosphate to amide I is smaller in new bone tissue than in the undamaged bone, indicating a higher organic content in the newly formed bone. The analysis of the width of the phosphate band suggests a crystallinity difference between both tissues, since the width was higher in the new bone than in the natural bone. These results suggest that the differences observed in bone aging processes by FTIR spectroscopic can be applied to the study of healing processes.

  6. Fourier transform infrared analysis of aerosol formed in the photooxidation of 1-octene

    NASA Astrophysics Data System (ADS)

    Palen, Edward J.; Allen, David T.; Pandis, Spyros N.; Paulson, Suzanne; Seinfeld, John H.; Flagan, Richard C.

    The chemical composition of aerosol generated in the photooxidation of 1-octene was examined using infrared microscopy interfaced with a low pressure impactor. The low pressure impactor segregated the aerosol into eight size fractions and deposited the aerosol onto ZnSe impaction substrates. The ZnSe surfaces were transparent in the mid-infrared region and therefore allowed direct analysis of the aerosol, with no extraction, using infrared microscopy. Infrared spectra of the size segregated aerosol showed strong absorbances due to ketone, alcohol, carboxylic acid and organonitrate functional groups. Absorbance features were relatively independent of particle size, with the exception of the carboxylic acid absorbances, which were found only in the largest aerosol size fractions. Molar loadings for each of the groups were estimated, based on model compound calibration standards. The molar loadings indicate that most aerosol species are multifunctional, with an average of one ketone group per molecule, an alcohol group in two of every three molecules and an organonitrate group in one of every three molecules.

  7. To See the World in a Grain of Sand: Recognizing the Origin of Sand Specimens by Diffuse Reflectance Infrared Fourier Transform Spectroscopy and Multivariate Exploratory Data Analysis

    ERIC Educational Resources Information Center

    Pezzolo, Alessandra De Lorenzi

    2011-01-01

    The diffuse reflectance infrared Fourier transform (DRIFT) spectra of sand samples exhibit features reflecting their composition. Basic multivariate analysis (MVA) can be used to effectively sort subsets of homogeneous specimens collected from nearby locations, as well as pointing out similarities in composition among sands of different origins.…

  8. 2-d Finite Element Code Postprocessor

    1996-07-15

    ORION is an interactive program that serves as a postprocessor for the analysis programs NIKE2D, DYNA2D, TOPAZ2D, and CHEMICAL TOPAZ2D. ORION reads binary plot files generated by the two-dimensional finite element codes currently used by the Methods Development Group at LLNL. Contour and color fringe plots of a large number of quantities may be displayed on meshes consisting of triangular and quadrilateral elements. ORION can compute strain measures, interface pressures along slide lines, reaction forcesmore » along constrained boundaries, and momentum. ORION has been applied to study the response of two-dimensional solids and structures undergoing finite deformations under a wide variety of large deformation transient dynamic and static problems and heat transfer analyses.« less

  9. Rotational Analysis of Bands in the High-Resolution Infrared Spectra of trans,trans- and cis,cis-1,4-DIFLUOROBUTADIENE-2-d1

    NASA Astrophysics Data System (ADS)

    Craig, Norman C.; Nemchick, Deacon J.; Easterday, Clay C.; Glor, Ethan C.; Williamson, Drew F. K.; Blake, Thomas A.; Sams, Robert L.

    2010-06-01

    Ground state rotational constants for a series of isotopomers are being sought for use in determining the semi-experimental equilibrium structures of the isomers of 1,4-difluorobutadiene. Because fluorine substitution has a large influence on CC bond lengths in C3 and C4 rings, we asked how fluorine substitution affects butadiene. trans,trans- and cis,cis-1,4-Difluorobutadiene-2-d1 have been synthesized, and high-resolution (0.0013 cm-1) infrared spectra have been recorded for these nonpolar species. Analysis of the rotational structure in several bands is reported. For the trans,trans isomer, the C-type band at 709.0 cm-1 for ν 21(a^") has been fully analyzed, and the C-type band at 914.3 cm-1 for ν 18(a^") has been partially analyzed. Interfering with the analysis of the second band is overlap of its R branch with the P branch of the A/B-type band for ν 13(a^') at 933 cm-1. For the cis,cis isomer, as much as possible of the C-type band (K_a^' = 10 to 34) for ν 20(a^") at 775.4 cm-1 has been analyzed. An A-type band for ν 13(a^') at 865.8 cm-1 has also been analyzed into the band center. Small inertial defects confirm that these molecules are planar. Ground state rotational constants are reported for both isomers in comparison with those for the normal species. N. C. Craig, M. C. Moore, C. F. Neese, D. C. Oertel, L. Pedraza, and T. Masiello, J. Mol. Spectrosc. 254, 39-46 (2009).

  10. Metabolic flux and metabolic network analysis of Penicillium chrysogenum using 2D [13C, 1H] COSY NMR measurements and cumulative bondomer simulation.

    PubMed

    van Winden, Wouter A; van Gulik, Walter M; Schipper, Dick; Verheijen, Peter J T; Krabben, Preben; Vinke, Jacobus L; Heijnen, Joseph J

    2003-07-01

    At present two alternative methods are available for analyzing the fluxes in a metabolic network: (1) combining measurements of net conversion rates with a set of metabolite balances including the cofactor balances, or (2) leaving out the cofactor balances and fitting the resulting free fluxes to measured (13)C-labeling data. In this study these two approaches are applied to the fluxes in the glycolysis and pentose phosphate pathway of Penicillium chrysogenum growing on either ammonia or nitrate as the nitrogen source, which is expected to give different pentose phosphate pathway fluxes. The presented flux analyses are based on extensive sets of 2D [(13)C, (1)H] COSY data. A new concept is applied for simulation of this type of (13)C-labeling data: cumulative bondomer modeling. The outcomes of the (13)C-labeling based flux analysis substantially differ from those of the pure metabolite balancing approach. The fluxes that are determined using (13)C-labeling data are shown to be highly dependent on the chosen metabolic network. Extending the traditional nonoxidative pentose phosphate pathway with additional transketolase and transaldolase reactions, extending the glycolysis with a fructose 6-phosphate aldolase/dihydroxyacetone kinase reaction sequence or adding a phosphoenolpyruvate carboxykinase reaction to the model considerably improves the fit of the measured and the simulated NMR data. The results obtained using the extended version of the nonoxidative pentose phosphate pathway model show that the transketolase and transaldolase reactions need not be assumed reversible to get a good fit of the (13)C-labeling data. Strict statistical testing of the outcomes of (13)C-labeling based flux analysis using realistic measurement errors is demonstrated to be of prime importance for verifying the assumed metabolic model. PMID:12740935

  11. Application of the windowed-Fourier-transform-based fringe analysis technique for investigating temperature and concentration fields in fluids.

    PubMed

    Mohanan, Sharika; Srivastava, Atul

    2014-04-10

    The present work is concerned with the development and application of a novel fringe analysis technique based on the principles of the windowed-Fourier-transform (WFT) for the determination of temperature and concentration fields from interferometric images for a range of heat and mass transfer applications. Based on the extent of the noise level associated with the experimental data, the technique has been coupled with two different phase unwrapping methods: the Itoh algorithm and the quality guided phase unwrapping technique for phase extraction. In order to generate the experimental data, a range of experiments have been carried out which include cooling of a vertical flat plate in free convection conditions, combustion of mono-propellant flames, and growth of organic as well as inorganic crystals from their aqueous solutions. The flat plate and combustion experiments are modeled as heat transfer applications wherein the interest is to determine the whole-field temperature distribution. Aqueous-solution-based crystal growth experiments are performed to simulate the mass transfer phenomena and the interest is to determine the two-dimensional solute concentration field around the growing crystal. A Mach-Zehnder interferometer has been employed to record the path-integrated quantity of interest (temperature and/or concentration) in the form of interferometric images in the experiments. The potential of the WFT method has also been demonstrated on numerically simulated phase data for varying noise levels, and the accuracy in phase extraction have been quantified in terms of the root mean square errors. Three levels of noise, i.e., 0%, 10%, and 20% have been considered. Results of the present study show that the WFT technique allows an accurate extraction of phase values that can subsequently be converted into two-dimensional temperature and/or concentration distribution fields. Moreover, since WFT is a local processing technique, speckle patterns and the inherent

  12. A rapid method for peroxide value determination in edible oils based on flow analysis with Fourier transform infrared spectroscopic detection.

    PubMed

    Ruíz, A; Ayora Cañada, M J; Lendl, B

    2001-02-01

    The development of an automated, rapid and highly precise method for determination of the peroxide value in edible oils based on a continuous flow system and Fourier transform infrared (FTIR) spectroscopic detection is described. The sample stream was mixed with a solvent mixture consisting of 25% (v/v) toluene in hexanol which contained triphenylphosphine (TPP). The hydroperoxides present in the sample reacted stoichiometrically with TPP to give triphenylphosphine oxide (TPPO) which has a characteristic and intense absorption band at 542 cm-1. A 10% (m/v) TPP solution in the solvent mixture and a 100 cm reaction coil were necessary for complete reaction. FTIR transmission spectra were recorded using a flow cell equipped with CsI windows having an optical pathlength of 100 microns. By using tert-butyl hydroperoxide spiked oil standards and evaluation of the band formed at 542 cm-1 a linear calibration graph covering the range 1-100 PV (peroxide value; mequiv O2 kg-1 oil) was obtained. The relative standard deviation was 0.23% (n = 11) and the throughput 24 samples h-1. The developed system was also applied to the determination of PV in olive, sunflower and corn oils, showing good agreement with the official reference method of the European Community which is based on titration using organic solvents. The results obtained clearly show that the developed method is superior to the standard wet chemical method, hence suggesting its application in routine analysis and quality control. PMID:11235111

  13. 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis.

    PubMed

    Hendrickson, Christopher L; Quinn, John P; Kaiser, Nathan K; Smith, Donald F; Blakney, Greg T; Chen, Tong; Marshall, Alan G; Weisbrod, Chad R; Beu, Steven C

    2015-09-01

    We describe the design and initial performance of the first 21 tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The 21 tesla magnet is the highest field superconducting magnet ever used for FT-ICR and features high spatial homogeneity, high temporal stability, and negligible liquid helium consumption. The instrument includes a commercial dual linear quadrupole trap front end that features high sensitivity, precise control of trapped ion number, and collisional and electron transfer dissociation. A third linear quadrupole trap offers high ion capacity and ejection efficiency, and rf quadrupole ion injection optics deliver ions to a novel dynamically harmonized ICR cell. Mass resolving power of 150,000 (m/Δm(50%)) is achieved for bovine serum albumin (66 kDa) for a 0.38 s detection period, and greater than 2,000,000 resolving power is achieved for a 12 s detection period. Externally calibrated broadband mass measurement accuracy is typically less than 150 ppb rms, with resolving power greater than 300,000 at m/z 400 for a 0.76 s detection period. Combined analysis of electron transfer and collisional dissociation spectra results in 68% sequence coverage for carbonic anhydrase. The instrument is part of the NSF High-Field FT-ICR User Facility and is available free of charge to qualified users. PMID:26091892

  14. Comparability of higher order structure in proteins: chemometric analysis of second-derivative amide I Fourier transform infrared spectra.

    PubMed

    Stockdale, Gregory; Murphy, Brian M; D'Antonio, Jennifer; Manning, Mark Cornell; Al-Azzam, Wasfi

    2015-01-01

    Comparing higher order structure (HOS) in therapeutic proteins is a significant challenge. Previously, we showed that changes in solution conditions produced detectable changes in the second-derivative amide I Fourier transform infrared (FTIR) spectra for a variety of model proteins. Those comparisons utilized vector-based approaches, such as spectral overlap and spectral correlation coefficients to quantify differences between spectra. In this study, chemometric analyses of the same data were performed, to classify samples into different groups based on the solution conditions received. The solution conditions were composed of various combinations of temperature, pH, and salt types. At first, principal component analysis (PCA) was used to visually demonstrate that FTIR spectra respond to changes in solution conditions, which, presumably indicates variations in HOS. This observed when samples from the same solution condition form clusters within a PCA score plot. The second approach, called soft independent modeling of class analogy (SIMCA), was conducted to account for the within-class experimental error for the lysozyme spectra. The DModX values, indicative of the distance of each spectra to their respective class models, was found to be a more sensitive quantitative indicator of changes in HOS, when compared with the modified area of overlap algorithm. The SIMCA approach provides a metric to determine whether new observations do, or do not belong to a particular class or group. Thus, SIMCA is the recommended approach when multiple samples from each condition are available. PMID:25382804

  15. Development of a practical spatial-spectral analysis protocol for breast histopathology using Fourier transform infrared spectroscopic imaging.

    PubMed

    Pounder, F Nell; Reddy, Rohith K; Bhargava, Rohit

    2016-06-23

    Breast cancer screening provides sensitive tumor identification, but low specificity implies that a vast majority of biopsies are not ultimately diagnosed as cancer. Automated techniques to evaluate biopsies can prevent errors, reduce pathologist workload and provide objective analysis. Fourier transform infrared (FT-IR) spectroscopic imaging provides both molecular signatures and spatial information that may be applicable for pathology. Here, we utilize both the spectral and spatial information to develop a combined classifier that provides rapid tissue assessment. First, we evaluated the potential of IR imaging to provide a diagnosis using spectral data alone. While highly accurate histologic [epithelium, stroma] recognition could be achieved, the same was not possible for disease [cancer, no-cancer] due to the diversity of spectral signals. Hence, we employed spatial data, developing and evaluating increasingly complex models, to detect cancers. Sub-mm tumors could be very confidently predicted as indicated by the quantitative measurement of accuracy via receiver operating characteristic (ROC) curve analyses. The developed protocol was validated with a small set and statistical performance used to develop a model that predicts study design for a large scale, definitive validation. The results of evaluation on different instruments, at higher noise levels, under a coarser spectral resolution and two sampling modes [transmission and transflection], indicate that the protocol is highly accurate under a variety of conditions. The study paves the way to validating IR imaging for rapid breast tumor detection, its statistical validation and potential directions for optimization of the speed and sampling for clinical deployment. PMID:27095431

  16. Imaging of Osteoarthritic Human Articular Cartilage using Fourier Transform Infrared Microspectroscopy Combined with Multivariate and Univariate Analysis.

    PubMed

    Oinas, J; Rieppo, L; Finnilä, M A J; Valkealahti, M; Lehenkari, P; Saarakkala, S

    2016-01-01

    The changes in chemical composition of human articular cartilage (AC) caused by osteoarthritis (OA) were investigated using Fourier transform infrared microspectroscopy (FTIR-MS). We demonstrate the sensitivity of FTIR-MS for monitoring compositional changes that occur with OA progression. Twenty-eight AC samples from tibial plateaus were imaged with FTIR-MS. Hyperspectral images of all samples were combined for K-means clustering. Partial least squares regression (PLSR) analysis was used to compare the spectra with the OARSI grade (histopathological grading of OA). Furthermore, the amide I and the carbohydrate regions were used to estimate collagen and proteoglycan contents, respectively. Spectral peak at 1338 cm(-1) was used to estimate the integrity of the collagen network. The layered structure of AC was revealed using the carbohydrate region for clustering. Statistically significant correlation was observed between the OARSI grade and the collagen integrity in the superficial (r = -0.55) and the deep (r = -0.41) zones. Furthermore, PLSR models predicted the OARSI grade from the superficial (r = 0.94) and the deep (r = 0.77) regions of the AC with high accuracy. Obtained results suggest that quantitative and qualitative changes occur in the AC composition during OA progression, and these can be monitored by the use of FTIR-MS. PMID:27445254

  17. Structural analysis of lignin residue from black liquor and its thermal performance in thermogravimetric-Fourier transform infrared spectroscopy.

    PubMed

    Hu, Jun; Xiao, Rui; Shen, Dekui; Zhang, Huiyan

    2013-01-01

    Structural characteristics of benzene-ethanol-extracted lignin (BEL) and acetone-extracted lignin (AL) precipitated from black liquor were identified by elemental analysis, FTIR, (13)C NMR, and (1)H NMR, while the thermal behaviors were examined with thermogravimetric-Fourier transform infrared spectroscopy (TG-FTIR). The frequency of β-O-4 bonds per 100 C9 monomeric units was 28 and 17 for BEL and AL. Two-stage pyrolysis processes were observed for the two lignins. The mass loss rate of the initial solvent evolution stage (110-180 °C) of BEL was greater than that of AL. The two lignins presented slightly different mass loss curves and evolution profiles of gases in the main pyrolysis stage (280-500 °C). A global kinetic model was proposed for lignin pyrolysis and activation energies of 39.5 and 38.8 kJ/mol was obtained for BEL and AL. The results enhance understanding of lignin pyrolysis and facilitate commercial utilization of black-liquor lignin. PMID:23220109

  18. Fourier Transform Mass Spectrometry and Nuclear Magnetic Resonance Analysis for the Rapid and Accurate Characterization of Hexacosanoylceramide.

    PubMed

    Ross, Charles W; Simonsick, William J; Bogusky, Michael J; Celikay, Recep W; Guare, James P; Newton, Randall C

    2016-01-01

    Ceramides are a central unit of all sphingolipids which have been identified as sites of biological recognition on cellular membranes mediating cell growth and differentiation. Several glycosphingolipids have been isolated, displaying immunomodulatory and anti-tumor activities. These molecules have generated considerable interest as potential vaccine adjuvants in humans. Accurate analyses of these and related sphingosine analogues are important for the characterization of structure, biological function, and metabolism. We report the complementary use of direct laser desorption ionization (DLDI), sheath flow electrospray ionization (ESI) Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) and high-field nuclear magnetic resonance (NMR) analysis for the rapid, accurate identification of hexacosanoylceramide and starting materials. DLDI does not require stringent sample preparation and yields representative ions. Sheath-flow ESI yields ions of the product and byproducts and was significantly better than monospray ESI due to improved compound solubility. Negative ion sheath flow ESI provided data of starting materials and products all in one acquisition as hexacosanoic acid does not ionize efficiently when ceramides are present. NMR provided characterization of these lipid molecules complementing the results obtained from MS analyses. NMR data was able to differentiate straight chain versus branched chain alkyl groups not easily obtained from mass spectrometry. PMID:27367671

  19. Fourier Transform Mass Spectrometry and Nuclear Magnetic Resonance Analysis for the Rapid and Accurate Characterization of Hexacosanoylceramide

    PubMed Central

    Ross, Charles W.; Simonsick, William J.; Bogusky, Michael J.; Celikay, Recep W.; Guare, James P.; Newton, Randall C.

    2016-01-01

    Ceramides are a central unit of all sphingolipids which have been identified as sites of biological recognition on cellular membranes mediating cell growth and differentiation. Several glycosphingolipids have been isolated, displaying immunomodulatory and anti-tumor activities. These molecules have generated considerable interest as potential vaccine adjuvants in humans. Accurate analyses of these and related sphingosine analogues are important for the characterization of structure, biological function, and metabolism. We report the complementary use of direct laser desorption ionization (DLDI), sheath flow electrospray ionization (ESI) Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) and high-field nuclear magnetic resonance (NMR) analysis for the rapid, accurate identification of hexacosanoylceramide and starting materials. DLDI does not require stringent sample preparation and yields representative ions. Sheath-flow ESI yields ions of the product and byproducts and was significantly better than monospray ESI due to improved compound solubility. Negative ion sheath flow ESI provided data of starting materials and products all in one acquisition as hexacosanoic acid does not ionize efficiently when ceramides are present. NMR provided characterization of these lipid molecules complementing the results obtained from MS analyses. NMR data was able to differentiate straight chain versus branched chain alkyl groups not easily obtained from mass spectrometry. PMID:27367671

  20. 21 Tesla Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: A National Resource for Ultrahigh Resolution Mass Analysis

    NASA Astrophysics Data System (ADS)

    Hendrickson, Christopher L.; Quinn, John P.; Kaiser, Nathan K.; Smith, Donald F.; Blakney, Greg T.; Chen, Tong; Marshall, Alan G.; Weisbrod, Chad R.; Beu, Steven C.

    2015-09-01

    We describe the design and initial performance of the first 21 tesla Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. The 21 tesla magnet is the highest field superconducting magnet ever used for FT-ICR and features high spatial homogeneity, high temporal stability, and negligible liquid helium consumption. The instrument includes a commercial dual linear quadrupole trap front end that features high sensitivity, precise control of trapped ion number, and collisional and electron transfer dissociation. A third linear quadrupole trap offers high ion capacity and ejection efficiency, and rf quadrupole ion injection optics deliver ions to a novel dynamically harmonized ICR cell. Mass resolving power of 150,000 ( m/Δm 50% ) is achieved for bovine serum albumin (66 kDa) for a 0.38 s detection period, and greater than 2,000,000 resolving power is achieved for a 12 s detection period. Externally calibrated broadband mass measurement accuracy is typically less than 150 ppb rms, with resolving power greater than 300,000 at m/z 400 for a 0.76 s detection period. Combined analysis of electron transfer and collisional dissociation spectra results in 68% sequence coverage for carbonic anhydrase. The instrument is part of the NSF High-Field FT-ICR User Facility and is available free of charge to qualified users.