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Sample records for 2d goddard cumulus

  1. Microphysics, Radiation and Surface Processes in the Goddard Cumulus Ensemble (GCE) Model

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo; Simpson, J.; Baker, D.; Braun, S.; Chou, M.-D.; Ferrier, B.; Johnson, D.; Khain, A.; Lang, S.; Lynn, B.

    2001-01-01

    The response of cloud systems to their environment is an important link in a chain of processes responsible for monsoons, frontal depression, El Nino Southern Oscillation (ENSO) episodes and other climate variations (e.g., 30-60 day intra-seasonal oscillations). Numerical models of cloud properties provide essential insights into the interactions of clouds with each other, with their surroundings, and with land and ocean surfaces. Significant advances are currently being made in the modeling of rainfall and rain-related cloud processes, ranging in scales from the very small up to the simulation of an extensive population of raining cumulus clouds in a tropical- or midlatitude-storm environment. The Goddard Cumulus Ensemble (GCE) model is a multi-dimensional nonhydrostatic dynamic/microphysical cloud resolving model. It has been used to simulate many different mesoscale convective systems that occurred in various geographic locations. In this paper, recent GCE model improvements (microphysics, radiation and surface processes) will be described as well as their impact on the development of precipitation events from various geographic locations. The performance of these new physical processes will be examined by comparing the model results with observations. In addition, the explicit interactive processes between cloud, radiation and surface processes will be discussed.

  2. Microphysics, Radiation and Surface Processes in the Goddard Cumulus Ensemble (GCE) Model

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo; Starr, David (Technical Monitor)

    2002-01-01

    One of the most promising methods to test the representation of cloud processes used in climate models is to use observations together with Cloud Resolving Models (CRMs). The CRMs use more sophisticated and realistic representations of cloud microphysical processes, and they can reasonably well resolve the time evolution, structure, and life cycles of clouds and cloud systems (size about 2-200 km). The CRMs also allow explicit interaction between out-going longwave (cooling) and in-coming solar (heating) radiation with clouds. Observations can provide the initial conditions and validation for CRM results. The Goddard Cumulus Ensemble (GCE) Model, a CRM, has been developed and improved at NASA/Goddard Space Flight Center over the past two decades. The GCE model has been used to understand the following: 1) water and energy cycles and their roles in the tropical climate system; 2) the vertical redistribution of ozone and trace constituents by individual clouds and well organized convective systems over various spatial scales; 3) the relationship between the vertical distribution of latent heating (phase change of water) and the large-scale (pre-storm) environment; 4) the validity of assumptions used in the representation of cloud processes in climate and global circulation models; and 5) the representation of cloud microphysical processes and their interaction with radiative forcing over tropical and midlatitude regions. Four-dimensional cloud and latent heating fields simulated from the GCE model have been provided to the TRMM Science Data and Information System (TSDIS) to develop and improve algorithms for retrieving rainfall and latent heating rates for TRMM and the NASA Earth Observing System (EOS). More than 90 referred papers using the GCE model have been published in the last two decades. Also, more than 10 national and international universities are currently using the GCE model for research and teaching. In this talk, five specific major GCE improvements: (1

  3. The Goddard Cumulus Ensemble Model (GCE): Improvements and Applications for Studying Precipitation Processes

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo; Lang, Stephen E.; Zeng, Xiping; Li, Xiaowen; Matsui, Toshi; Mohr, Karen; Posselt, Derek; Chern, Jiundar; Peters-Lidard, Christa; Norris, Peter M.; Kang, In-Sik; Choi, Ildae; Hou, Arthur; Lau, K.-M.; Yang, Young-Min

    2014-01-01

    Convection is the primary transport process in the Earth's atmosphere. About two-thirds of the Earth's rainfall and severe floods derive from convection. In addition, two-thirds of the global rain falls in the tropics, while the associated latent heat release accounts for three-fourths of the total heat energy for the Earth's atmosphere. Cloud-resolving models (CRMs) have been used to improve our understanding of cloud and precipitation processes and phenomena from micro-scale to cloud-scale and mesoscale as well as their interactions with radiation and surface processes. CRMs use sophisticated and realistic representations of cloud microphysical processes and can reasonably well resolve the time evolution, structure, and life cycles of clouds and cloud systems. CRMs also allow for explicit interaction between clouds, outgoing longwave (cooling) and incoming solar (heating) radiation, and ocean and land surface processes. Observations are required to initialize CRMs and to validate their results. The Goddard Cumulus Ensemble model (GCE) has been developed and improved at NASA/Goddard Space Flight Center over the past three decades. It is amulti-dimensional non-hydrostatic CRM that can simulate clouds and cloud systems in different environments. Early improvements and testing were presented in Tao and Simpson (1993) and Tao et al. (2003a). A review on the application of the GCE to the understanding of precipitation processes can be found in Simpson and Tao (1993) and Tao (2003). In this paper, recent model improvements (microphysics, radiation and land surface processes) are described along with their impact and performance on cloud and precipitation events in different geographic locations via comparisons with observations. In addition, recent advanced applications of the GCE are presented that include understanding the physical processes responsible for diurnal variation, examining the impact of aerosols (cloud condensation nuclei or CCN and ice nuclei or IN) on

  4. The Goddard Cumulus Ensemble Model: Model Description and Its Application for Studying the TOGA COARE and GATE Convective Systems

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo; Einaudi, Franco (Technical Monitor)

    2001-01-01

    The Goddard Cumulus Ensemble (GCE) model was utilized in two and three dimensions in order to examine the behavior and response of simulated deep tropical cloud systems occurred in west Pacific warm pool region and Atlantic ocean. The periods chosen for simulation were convectively active period over the TOGA-COARE IFA (19-27 December 1992) and GATE (September 1 to 7, 1974). The TOGA COARE IFA period was also in the framework of the GEWEX Cloud System Study (GCSS) WG4 case 2. We will examine the differences between the microphysics (warm rain and ice processes, evaporation/sublimation and condensation/deposition), Q1 (Temperature) and Q2 (Water vapor) budgets between these two convective events occurred in different large-scale environments. The contribution of stratiform precipitation and its relationship to the vertical shear of the large-scale horizontal wind will also be examined. The results from GCSS model intercomparsion will be presented. The new improvements (i.e., microphysics, cloud radiation interaction, surface processes and numerical advection scheme) of the GCE model as well as their sensitivity to the model results will be discussed.

  5. Role of a cumulus parameterization scheme in simulating atmospheric circulation and rainfall in the nine-layer Goddard Laboratory for Atmospheres General Circulation Model

    NASA Technical Reports Server (NTRS)

    Sud, Y. C.; Chao, Winston C.; Walker, G. K.

    1992-01-01

    The influence of a cumulus convection scheme on the simulated atmospheric circulation and hydrologic cycle is investigated by means of a coarse version of the GCM. Two sets of integrations, each containing an ensemble of three summer simulations, were produced. The ensemble sets of control and experiment simulations are compared and differentially analyzed to determine the influence of a cumulus convection scheme on the simulated circulation and hydrologic cycle. The results show that cumulus parameterization has a very significant influence on the simulation circulation and precipitation. The upper-level condensation heating over the ITCZ is much smaller for the experiment simulations as compared to the control simulations; correspondingly, the Hadley and Walker cells for the control simulations are also weaker and are accompanied by a weaker Ferrel cell in the Southern Hemisphere. Overall, the difference fields show that experiment simulations (without cumulus convection) produce a cooler and less energetic atmosphere.

  6. Summary of Cumulus Parameterization Workshop

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo; Starr, David OC.; Hou, Arthur; Newman, Paul; Sud, Yogesh

    2002-01-01

    A workshop on cumulus parameterization took place at the NASA Goddard Space Flight Center from December 3-5, 2001. The major objectives of this workshop were (1) to review the problem of representation of moist processes in large-scale models (mesoscale models, Numerical Weather Prediction models and Atmospheric General Circulation Models), (2) to review the state-of-the-art in cumulus parameterization schemes, and (3) to discuss the need for future research and applications. There were a total of 31 presentations and about 100 participants from the United States, Japan, the United Kingdom, France and South Korea. The specific presentations and discussions during the workshop are summarized in this paper.

  7. The NASA-Goddard Multi-Scale Modeling Framework - Land Information System: Global Land/atmosphere Interaction with Resolved Convection

    NASA Technical Reports Server (NTRS)

    Mohr, Karen Irene; Tao, Wei-Kuo; Chern, Jiun-Dar; Kumar, Sujay V.; Peters-Lidard, Christa D.

    2013-01-01

    The present generation of general circulation models (GCM) use parameterized cumulus schemes and run at hydrostatic grid resolutions. To improve the representation of cloud-scale moist processes and landeatmosphere interactions, a global, Multi-scale Modeling Framework (MMF) coupled to the Land Information System (LIS) has been developed at NASA-Goddard Space Flight Center. The MMFeLIS has three components, a finite-volume (fv) GCM (Goddard Earth Observing System Ver. 4, GEOS-4), a 2D cloud-resolving model (Goddard Cumulus Ensemble, GCE), and the LIS, representing the large-scale atmospheric circulation, cloud processes, and land surface processes, respectively. The non-hydrostatic GCE model replaces the single-column cumulus parameterization of fvGCM. The model grid is composed of an array of fvGCM gridcells each with a series of embedded GCE models. A horizontal coupling strategy, GCE4fvGCM4Coupler4LIS, offered significant computational efficiency, with the scalability and I/O capabilities of LIS permitting landeatmosphere interactions at cloud-scale. Global simulations of 2007e2008 and comparisons to observations and reanalysis products were conducted. Using two different versions of the same land surface model but the same initial conditions, divergence in regional, synoptic-scale surface pressure patterns emerged within two weeks. The sensitivity of largescale circulations to land surface model physics revealed significant functional value to using a scalable, multi-model land surface modeling system in global weather and climate prediction.

  8. A Goddard Multi-Scale Modeling System with Unified Physics

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo

    2008-01-01

    A multi-scale modeling system with unified physics has been developed at NASA Goddard Space Flight Center (GSFC). The system consists of an MMF, the coupled NASA Goddard finite-volume GCM (fvGCM) and Goddard Cumulus Ensemble model (GCE, a CRM); the state-of-the-art Weather Research and Forecasting model (WRF) and the stand alone GCE. These models can share the same microphysical schemes, radiation (including explicitly calculated cloud optical properties), and surface models that have been developed, improved and tested for different environments. The following is presented in this report: (1) a brief review of the GCE model and its applications on the impact of aerosols on deep precipitation processes, (2) the Goddard MMF and the major difference between two existing MMFs (CSU MMF and Goddard MMF), and preliminary results (the comparison with traditional GCMs), and (3) a discussion on the Goddard WRF version (its developments and applications).

  9. Goddard Cumulus Ensemble (GCE) Model: Application for Understanding Preciptation Processes

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo; Einaudi, Franco (Technical Monitor)

    2000-01-01

    The global hydrological cycle is central to climate system interactions and the key to understanding their behavior. Rainfall and its associated precipitation processes are a key link in the hydrologic cycle. Fresh water provided by tropical rainfall and its variability can exert a large impact upon the structure of the upper ocean layer. In addition, approximately two-thirds of the global rain falls in the Tropics, while the associated latent heat release accounts for about three-fourths of the total heat energy for the Earth's atmosphere. Precipitation from convective cloud systems comprises a large portion of tropical heating and rainfall. Furthermore, the vertical distribution of convective latent-heat releases modulates large-scale tropical circulations (e.g., the 30-60-day intraseasonal oscillation), which, in turn, impacts midlatitude weather through teleconnection patterns such as those associated with El Nino. Shifts in these global circulations can result in prolonged periods of droughts and floods, thereby exerting a tremendous impact upon the biosphere and human habitation. And yet, monthly rainfall over the tropical oceans is still not known within a factor of two over large (5 degrees latitude by 5 degrees longitude) areas. Hence, the Tropical Rainfall Measuring Mission (TRMM), a joint U.S./Japan space project, can provide a more accurate measurement of rainfall as well as estimate the four-dimensional structure of diabatic heating over the global tropics. The distributions of rainfall and inferred heating can be used to advance our understanding of the global energy and water cycle. In addition, this information can be used for global circulation and climate models for testing and improving their parameterizations.

  10. Goddard Welcomes SISTER

    NASA Video Gallery

    The Goddard Space Flight Center in Greenbelt, Md., hosted a weeklong summer institute, SISTER, for the purpose of increasing the awareness of and providing opportunities for middle school girls to ...

  11. Dr. Goddard Transports Rocket

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Dr. Robert H. Goddard tows his rocket to the launching tower behind a Model A Ford truck, 15 miles northwest of Roswell, New Mexico. 1930- 1932. Dr. Goddard has been recognized as the 'Father of American Rocketry' and as one of three pioneers in the theoretical exploration of space. Robert Hutchings Goddard was born in Worcester, Massachusetts, on October 15, 1882. He was a theoretical scientist as well as a practical engineer. His dream was the conquest of the upper atmosphere and ultimately space through the use of rocket propulsion. Dr. Goddard, who died in 1945, was probably as responsible for the dawning of the Space Age as the Wright Brothers were for the begining of the Air Age. Yet his work attracted little serious attention during his lifetime. When the United States began to prepare for the conquest of space in the 1950's, American rocket scientists began to recognize the debt owed to the New England professor. They discovered that it was virtually impossible to construct a rocket or launch a satellite without acknowledging the work of Dr. Goddard. This great legacy was covered by more than 200 patents, many of which were issued after his death.

  12. A Goddard Multi-Scale Modeling System with Unified Physics

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo

    2010-01-01

    A multi-scale modeling system with unified physics has been developed at NASA Goddard Space Flight Center (GSFC). The system consists of an MMF, the coupled NASA Goddard finite-volume GCM (fvGCM) and Goddard Cumulus Ensemble model (GCE, a CRM); the state-of-the-art Weather Research and Forecasting model (WRF) and the stand alone GCE. These models can share the same microphysical schemes, radiation (including explicitly calculated cloud optical properties), and surface models that have been developed, improved and tested for different environments. In this talk, I will present: (1) A brief review on GCE model and its applications on the impact of the aerosol on deep precipitation processes, (2) The Goddard MMF and the major difference between two existing MMFs (CSU MMF and Goddard MMF), and preliminary results (the comparison with traditional GCMs), and (3) A discussion on the Goddard WRF version (its developments and applications). We are also performing the inline tracer calculation to comprehend the physical processes (i.e., boundary layer and each quadrant in the boundary layer) related to the development and structure of hurricanes and mesoscale convective systems. In addition, high - resolution (spatial. 2km, and temporal, I minute) visualization showing the model results will be presented.

  13. A Goddard Multi-Scale Modeling System with Unified Physics

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo

    2010-01-01

    A multi-scale modeling system with unified physics has been developed at NASA Goddard Space Flight Center (GSFC). The system consists of an MMF, the coupled NASA Goddard finite-volume GCM (fvGCM) and Goddard Cumulus Ensemble model (GCE, a CRM); the state-of-the-art Weather Research and Forecasting model (WRF) and the stand alone GCE. These models can share the same microphysical schemes, radiation (including explicitly calculated cloud optical properties), and surface models that have been developed, improved and tested for different environments. In this talk, I will present: (1) A brief review on GCE model and its applications on the impact of the aerosol on deep precipitation processes, (2) The Goddard MMF and the major difference between two existing MMFs (CSU MMF and Goddard MMF), and preliminary results (the comparison with traditional GCMs), and (3) A discussion on the Goddard WRF version (its developments and applications). We are also performing the inline tracer calculation to comprehend the ph ysical processes (i.e., boundary layer and each quadrant in the boundary layer) related to the development and structure of hurricanes and mesoscale convective systems.

  14. Goddard Summer Interns: Danielle Wood

    NASA Video Gallery

    Profile of Goddard intern Danielle Wood. Danielle is interning at Goddard in the Innovative Partnerships Program and at NASA Headquarters in the Office of the Chief Technologist in the summer of 20...

  15. Goddard Ground System Environment

    NASA Technical Reports Server (NTRS)

    Liu, Ben

    2009-01-01

    This slide presentation reviews the Goddard Mission Services Evolution Center's work in providing the Ground System Infrastructure to allow for standard interfaces, and allow for a mix of heritage and new components. This software has been used by NASA and other Government users. Telemetry and command services are also provided as are mission planning and scheduling systems. Other areas that the presentation covers are work on trending systems, and data management system.

  16. Goddard Robotic Telescope

    SciTech Connect

    Sakamoto, Takanori; Donato, Davide; Gehrels, Neil; Okajima, Takashi; Ukwatta, Tilan N.

    2009-05-25

    We are constructing the 14'' fully automated optical robotic telescope, Goddard Robotic Telescope (GRT), at the Goddard Geophysical and Astronomical Observatory. The aims of our robotic telescope are 1) to follow-up the Swift/Fermi Gamma-Ray Bursts (GRBs) and 2) to perform the coordinated optical observations of the Fermi/Large Area Telescope (LAT) Active Galactic Nuclei (AGN). Our telescope system consists of the 14'' Celestron Optical Telescope Assembly (OTA), the Astro-Physics 1200GTO mount, the Apogee U47 CCD camera, the JMI's electronic focuser, and the Finger Lake Instrumentation's color filter wheel with U, B, V, R and I filters. With the focal reducer, 20'x20' field of view has been achieved. The observatory dome is the Astro Haven's 7 ft clam-shell dome. We started the scientific observations on mid-November 2008. While not observing our primary targets (GRBs and AGNs), we are planning to open our telescope time to the public for having a wider use of our telescope in both a different research field and an educational purpose.

  17. Red-based cumulus.

    PubMed

    Gedzelman, Stanley David

    2015-02-01

    Observations and model simulations of cumulus clouds whose bases are tinted red when the Sun is well above the horizon are presented. Conditions for seeing red bases include (1) a red underlying surface (which may consist of dust clouds, as from haboobs) with high albedo, (2) small fractional cloud cover when the Sun is far enough below the zenith for direct sunlight to illuminate much of the surface directly below and around cloud base, (3) optically thick clouds so that the bases are dark, and (4) clouds with bases that are near enough to the observer to appear high in the sky so that the admixture of scattered light from the intervening atmosphere is minimized. PMID:25967822

  18. Goddard Visiting Scientist Program

    NASA Technical Reports Server (NTRS)

    2000-01-01

    Under this Indefinite Delivery Indefinite Quantity (IDIQ) contract, USRA was expected to provide short term (from I day up to I year) personnel as required to provide a Visiting Scientists Program to support the Earth Sciences Directorate (Code 900) at the Goddard Space Flight Center. The Contractor was to have a pool, or have access to a pool, of scientific talent, both domestic and international, at all levels (graduate student to senior scientist), that would support the technical requirements of the following laboratories and divisions within Code 900: 1) Global Change Data Center (902); 2) Laboratory for Atmospheres (Code 910); 3) Laboratory for Terrestrial Physics (Code 920); 4) Space Data and Computing Division (Code 930); 5) Laboratory for Hydrospheric Processes (Code 970). The research activities described below for each organization within Code 900 were intended to comprise the general scope of effort covered under the Visiting Scientist Program.

  19. Explore at NASA Goddard Promo

    NASA Video Gallery

    NASA's Goddard Space Flight Center in Greenbelt, Md., will again open its gates to welcome the regional community for a day of fun-filled activities, hands-on demonstrations, entertainment, and foo...

  20. Goddard Summer Interns: Alejandro Arambula

    NASA Video Gallery

    Alejandro Arambula is an aerospace engineering student at M.I.T. and a 2011 summer intern in Goddard's Propulsion Lab. This summer he is working with his mentor Khary Parker in building a test asse...

  1. Astronaut Steve Swanson Visits Goddard

    NASA Video Gallery

    On Tuesday, 3 March 2015, a special guest visited NASA Goddard Space Flight Center during his time back on Earth. Steven Swanson, NASA astronaut, intrigued the audience by highlighting his adventur...

  2. Goddard Virtual Tour: Part 1

    NASA Video Gallery

    Goddard Chief Scientist Jim Garvin takes us on a tour of the life of a spacecraft, from the idea to the collection of data in orbit. Each segment looks at a different phase of the spacecraft and it...

  3. Simulated KWAJEX Convective Systems Using a 2D and 3D Cloud Resolving Model and Their Comparisons with Radar Observations

    NASA Technical Reports Server (NTRS)

    Shie, Chung-Lin; Tao, Wei-Kuo; Simpson, Joanne

    2003-01-01

    The 1999 Kwajalein Atoll field experiment (KWAJEX), one of several major TRMM (Tropical Rainfall Measuring Mission) field experiments, has successfully obtained a wealth of information and observation data on tropical convective systems over the western Central Pacific region. In this paper, clouds and convective systems that developed during three active periods (Aug 7-12, Aug 17-21, and Aug 29-Sep 13) around Kwajalein Atoll site are simulated using both 2D and 3D Goddard Cumulus Ensemble (GCE) models. Based on numerical results, the clouds and cloud systems are generally unorganized and short lived. These features are validated by radar observations that support the model results. Both the 2D and 3D simulated rainfall amounts and their stratiform contribution as well as the heat, water vapor, and moist static energy budgets are examined for the three convective episodes. Rainfall amounts are quantitatively similar between the two simulations, but the stratiform contribution is considerably larger in the 2D simulation. Regardless of dimension, fo all three cases, the large-scale forcing and net condensation are the two major physical processes that account for the evolution of the budgets with surface latent heat flux and net radiation solar and long-wave radiation)being secondary processes. Quantitative budget differences between 2D and 3D as well as between various episodes will be detailed.Morover, simulated radar signatures and Q1/Q2 fields from the three simulations are compared to each other and with radar and sounding observations.

  4. Precipitation Processes Developed During ARM (1997), TOGA COARE (1992), GATE (1974), SCSMEX (1998), and KWAJEX (1999): Consistent 2D, Semi-3D and 3D Cloud Resolving Model Simulations

    NASA Technical Reports Server (NTRS)

    Tao, W-K.

    2003-01-01

    Real clouds and cloud systems are inherently three-dimensional (3D). Because of the limitations in computer resources, however, most cloud-resolving models (CRMs) today are still two-dimensional (2D). A few 3D CRMs have been used to study the response of clouds to large-scale forcing. In these 3D simulations, the model domain was small, and the integration time was 6 hours. Only recently have 3D experiments been performed for multi-day periods for tropical cloud systems with large horizontal domains at the National Center for Atmospheric Research (NACAR) and at NASA Goddard Space Flight Center . At Goddard, a 3D Goddard Cumulus Ensemble (GCE) model was used to simulate periods during TOGA COARE, SCSMEX and KWAJEX using 512 by 512 km domain (with 2 km resolution). The results indicate that surface precipitation and latent heating profiles are very similar between the 2D and 3D GCE model simulations. The reason for the strong similarity between the 2D and 3D CRM simulations is that the same observed large-scale advective tendencies of potential temperature, water vapor mixing ratio, and horizontal momentum were used as the main focusing in both the 2D and 3D models. Interestingly, the 2D and 3D versions of the CRM used at CSU showed significant differences in the rainfall and cloud statistics for three ARM cases. The major objectives of this paper are: (1) to assess the performance of the super-parameterization technique, (2) calculate and examine the surface energy (especially radiation) and water budgets, and (3) identify the differences and similarities in the organization and entrainment rates of convection between simulated 2D and 3D cloud systems.

  5. VERTICAL TRANSPORT BY CUMULUS CLOUDS

    EPA Science Inventory

    The exchange process between the mixed layer and the free troposphere by non precipitating cumulus convective clouds is examined based on results of two field experiments conducted in Lexington, Kentucky. The first experiment utilized SF6 tracer gas released from one aircraft and...

  6. Marshall Team Recreates Goddard Rocket

    NASA Technical Reports Server (NTRS)

    2003-01-01

    In honor of the Centernial of Flight celebration and commissioned by the American Institute of Aeronautics and Astronautics (AIAA), a team of engineers from Marshall Space Flight Center (MSFC) built a replica of the first liquid-fueled rocket. The original rocket, designed and built by rocket engineering pioneer Robert H. Goddard in 1926, opened the door to modern rocketry. Goddard's rocket reached an altitude of 41 feet while its flight lasted only 2.5 seconds. The Marshall design team's plan was to stay as close as possible to an authentic reconstruction of Goddard's rocket. The same propellants were used - liquid oxygen and gasoline - as available during Goddard's initial testing and firing. The team also tried to construct the replica using the original materials and design to the greatest extent possible. By purposely using less advanced techniques and materials than many that are available today, the team encountered numerous technical challenges in testing the functional hardware. There were no original blueprints or drawings, only photographs and notes. However, this faithful adherence to historical accuracy has also allowed the team to experience many of the same challenges Goddard faced 77 years ago, and more fully appreciate the genius of this extraordinary man. The replica will undergo ground tests at MSFC this summer.

  7. Goddard Geophysical and Astronomical Observatory

    NASA Technical Reports Server (NTRS)

    Redmond, Jay; Kodak, Charles

    2001-01-01

    This report summarizes the technical parameters and the technical staff of the Very Long Base Interferometry (VLBI) system at the fundamental station Goddard Geophysical and Astronomical Observatory (GGAO). It also gives an overview about the VLBI activities during the previous year. The outlook lists the outstanding tasks to improve the performance of GGAO.

  8. The Goddard VLBI SINEX Files

    NASA Technical Reports Server (NTRS)

    Ma, Chopo; Petrov, Leonid

    2002-01-01

    The Goddard VLBI group generates SINEX files for individual 24-hr sessions and multiyear TRF solutions. Each 24-hr file includes the reduced normal matrix for the station positions, EOP, and EOP rates. A global Terrestrial Reference Frame (TRF) SINEX file has the reduced normal matrix for station positions and velocities but no EOP parameters. Both types of normal matrix are free from any datum constraints and are designed for combination solutions that will later apply the necessary datum constraints. The SINEX files also contain blocks that provide the constraints and covariance of well-defined 24-hr or global TRF solutions. These blocks are not yet part of the SINEX 2.0 specification. For the TRF solutions the Goddard VLBI group also generates the corresponding EOP time series. SINEX files and EOP time series are distributed through the IVS. The algorithms for generating the various blocks and the proper use of such SINEX files will be discussed.

  9. Regional-Scale Modeling at NASA Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Tao, W.-K.; Adler, R.; Baker, D.; Braun, S.; Chou, M.-D.; Jasinski, M. F.; Jia, Y.; Kakar, R.; Karyampudi, M.; Lang, S.

    2003-01-01

    Over the past decade, the Goddard Mesoscale Modeling and Dynamics Group has used a popular regional scale model, MM5, to study precipitation processes. Our group is making contributions to the MM5 by incorporating the following physical and numerical packages: improved Goddard cloud processes, a land processes model (Parameterization for Land-Atmosphere-Cloud Exchange - PLACE), efficient but sophisticated radiative processes, conservation of hydrometeor mass (water budget), four-dimensional data assimilation for rainfall, and better computational methods for trace gas transport. At NASA Goddard, the MM5 has been used to study: (1) the impact of initial conditions, assimilation of satellite-derived rainfall, and cumulus parameterizations on rapidly intensifying oceanic cyclones, hurricanes and typhoons, (2) the dynamic and thermodynamic processes associated with the development of narrow cold frontal rainbands, (3) regional climate and water cycles, (4) the impact of vertical transport by clouds and lightning on trace gas distributiodproduction associated with South and North American mesoscale convective systems, (5) the development of a westerly wind burst (WWB) that occurred during the TOGA COARE and the diurnal variation of precipitation in the tropics, (6) a Florida sea breeze convective event and a Mid-US flood event using a sophisticated land surface model, (7) the influence of soil heterogeneity on land surface energy balance in the southwest GCIP region, (8) explicit simulations (with 1.33 to 4 km horizontal resolution) of hurricanes Bob (1991) and Bonnie (1998), (9) a heavy precipitation event over Taiwan, and (10) to make real time forecasts for a major NASA field program. In this paper, the modifications and simulated cases will be described and discussed.

  10. The Goddard optical communications program

    NASA Astrophysics Data System (ADS)

    Seery, B. D.

    1990-07-01

    The main areas of research being conducted at NASA Goddard Space Flight Center are reviewed. Research on transmitter source technology is addressed, emphasizing the development of AlGaAs semiconductor laser diodes. Research on receiver technology is examined, and progress being made in the development of the Pointing, Acquisition, and Tracking System (PATS) is reviewed. Plans for an in-space technology demonstration are briefly discussed.

  11. Goddard Geophysical and Astronomical Observatory

    NASA Technical Reports Server (NTRS)

    Figueroa, Ricardo

    2013-01-01

    This report summarizes the technical parameters and the technical staff of the VLBI system at the fundamental station GGAO. It also gives an overview about the VLBI activities during the report year. The Goddard Geophysical and Astronomical Observatory (GGAO) consists of a 5-meter radio telescope for VLBI, a new 12-meter radio telescope for VLBI2010 development, a 1-meter reference antenna for microwave holography development, an SLR site that includes MOBLAS-7, the NGSLR development system, and a 48" telescope for developmental two-color Satellite Laser Ranging, a GPS timing and development lab, a DORIS system, meteorological sensors, and a hydrogen maser. In addition, we are a fiducial IGS site with several IGS/IGSX receivers. GGAO is located on the east coast of the United States in Maryland. It is approximately 15 miles NNE of Washington, D.C. in Greenbelt, Maryland.

  12. CUMULUS CLOUD VENTING OF MIXED LAYER OZONE

    EPA Science Inventory

    Observations are presented which substantiate the hypothesis that significant vertical exchange of ozone and aerosols (and possibly other compounds) occurs between the mixed layer and the free troposphere during cumulus cloud convective activity. The experiments conducted in July...

  13. Goddard Earth Sciences and Technology Center (GEST)

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This document summarizes the activities of the Goddard Earth Sciences and Technology Center (GEST), a consortium of scientists and engineers led by the University of Maryland, Baltimore County (UMBC), during the contract reporting period. Topics covered include: new programs, eligibility and selection criteria, Goddard Coastal Research Graduate Fellowship Program and staffing changes.

  14. NASA Goddard's Application of Lasers in Space

    NASA Technical Reports Server (NTRS)

    Abshire, James B.; Krainak, Michael A.; Degnan, John J.

    2007-01-01

    Researchers at NASA Goddard have been applying lasers for space measurements for over 4 decades, starting with satellite laser ranging in the mid 1960s. This talk will briefly review the history of Goddard's application to lasers to the scientific exploration of space, provide an overview of its ongoing laser-related programs, and give some possibilities for the future.

  15. Shallow cumulus rooted in photosynthesis

    NASA Astrophysics Data System (ADS)

    Vila-Guerau Arellano, J.; Ouwersloot, H.; Horn, G.; Sikma, M.; Jacobs, C. M.; Baldocchi, D.

    2014-12-01

    We investigate the interaction between plant evapotranspiration, controlled by photosynthesis (for a low vegetation cover by C3 and C4 grasses), and the moist thermals that are responsible for the formation and development of shallow cumulus clouds (SCu). We perform systematic numerical experiments at fine spatial scales using large-eddy simulations explicitly coupled to a plant-physiology model. To break down the complexity of the vegetation-atmospheric system at the diurnal scales, we design the following experiments with increasing complexity: (a) clouds that are transparent to radiation, (b) clouds that shade the surface from the incoming shortwave radiation and (c) plant stomata whose apertures react with an adjustment in time to cloud perturbations. The shading by SCu leads to a strong spatial variability in photosynthesis and the surface energy balance. As a result, experiment (b) simulates SCu that are characterized by less extreme and less skewed values of the liquid water path and cloud-base height. These findings are corroborated by the calculation of characteristics lengths scales of the thermals and clouds using autocorrelation and spectral analysis methods. We find that experiments (a) and (b) are characterized by similar cloud cover evolution, but different cloud population characteristics. Experiment (b), including cloud shading, is characterized by smaller clouds, but closer to each other. By performing a sensitivity analysis on the exchange of water vapor and carbon dioxide at the canopy level, we show that the larger water-use efficiency of C4 grass leads to two opposing effects that directly influence boundary-layer clouds: the thermals below the clouds are more vigorous and deeper driven by a larger buoyancy surface flux (positive effect), but are characterized by less moisture content (negative effect). We conclude that under the investigated mid-latitude atmospheric and well-watered soil conditions, SCu over C4 grass fields is characterized

  16. Dr. Robert H. Goddard and His Rockets

    NASA Technical Reports Server (NTRS)

    1926-01-01

    Dr. Robert H. Goddard and liquid oxygen-gasoline rocket in the frame from which it was fired on March 16, 1926, at Auburn, Mass. It flew for only 2.5 seconds, climbed 41 feet, and landed 184 feet away in a cabbage patch. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  17. A Lifeline Home: Goddard's Final Shuttle Mission

    NASA Video Gallery

    Controllers at Goddard's Network Integration Center share their thoughts as the 30-year-old Shuttle Program comes to an end with the final flight of STS-135, which concluded with a textbook landing...

  18. Indiana School for the Blind Visits Goddard

    NASA Video Gallery

    This video shows highlights of the Indiana School for the Blind and Visually Impaired, and the Indian Creek Public High School visit to NASA's Goddard Space Flight Center in June 2011. Both blind a...

  19. Goddard trajectory determination subsystem: Mathematical specifications

    NASA Technical Reports Server (NTRS)

    Wagner, W. E. (Editor); Velez, C. E. (Editor)

    1972-01-01

    The mathematical specifications of the Goddard trajectory determination subsystem of the flight dynamics system are presented. These specifications include the mathematical description of the coordinate systems, dynamic and measurement model, numerical integration techniques, and statistical estimation concepts.

  20. A Goddard Multi-Scale Modeling System with Unified Physics

    NASA Technical Reports Server (NTRS)

    Tao, W.K.; Anderson, D.; Atlas, R.; Chern, J.; Houser, P.; Hou, A.; Lang, S.; Lau, W.; Peters-Lidard, C.; Kakar, R.; Kumar, S.; Lapenta, W.; Li, X.; Matsui, T.; Rienecker, M.; Shen, B.W.; Shi, J.J.; Simpson, J.; Zeng, X.

    2008-01-01

    Numerical cloud resolving models (CRMs), which are based the non-hydrostatic equations of motion, have been extensively applied to cloud-scale and mesoscale processes during the past four decades. Recent GEWEX Cloud System Study (GCSS) model comparison projects have indicated that CRMs agree with observations in simulating various types of clouds and cloud systems from different geographic locations. Cloud resolving models now provide statistical information useful for developing more realistic physically based parameterizations for climate models and numerical weather prediction models. It is also expected that Numerical Weather Prediction (NWP) and regional scale model can be run in grid size similar to cloud resolving model through nesting technique. Current and future NASA satellite programs can provide cloud, precipitation, aerosol and other data at very fine spatial and temporal scales. It requires a coupled global circulation model (GCM) and cloud-scale model (termed a szrper-parameterization or multi-scale modeling -framework, MMF) to use these satellite data to improve the understanding of the physical processes that are responsible for the variation in global and regional climate and hydrological systems. The use of a GCM will enable global coverage, and the use of a CRM will allow for better and more sophisticated physical parameterization. NASA satellite and field campaign can provide initial conditions as well as validation through utilizing the Earth Satellite simulators. At Goddard, we have developed a multi-scale modeling system with unified physics. The modeling system consists a coupled GCM-CRM (or MMF); a state-of-the-art weather research forecast model (WRF) and a cloud-resolving model (Goddard Cumulus Ensemble model). In these models, the same microphysical schemes (2ICE, several 3ICE), radiation (including explicitly calculated cloud optical properties), and surface models are applied. In addition, a comprehensive unified Earth Satellite

  1. Marshall Team Fires Recreated Goddard Rocket

    NASA Technical Reports Server (NTRS)

    2003-01-01

    In honor of the Centernial of Flight Celebration and commissioned by the American Institute of Aeronautics and Astronautics (AIAA), a team of engineers from Marshall Space Flight Center (MSFC) built a replica of the first liquid-fueled rocket. The original rocket, designed and built by rocket engineering pioneer Robert H. Goddard in 1926, opened the door to modern rocketry. Goddard's rocket reached an altitude of 41 feet while its flight lasted only 2.5 seconds. The Marshall design team's plan was to stay as close as possible to an authentic reconstruction of Goddard's rocket. The same propellants were used - liquid oxygen and gasoline - as available during Goddard's initial testing and firing. The team also tried to construct the replica using the original materials and design to the greatest extent possible. By purposely using less advanced techniques and materials than many that are available today, the team encountered numerous technical challenges in testing the functional hardware. There were no original blueprints or drawings, only photographs and notes. However, this faithful adherence to historical accuracy has allowed the team to experience many of the same challenges Goddard faced 77 years ago, and more fully appreciate the genius of this extraordinary man. In this photo, the replica is shown firing in the A-frame launch stand in near-flight configuration at MSFC's Test Area 116 during the American Institute of Aeronautics and Astronautics 39th Joint Propulsion Conference on July 23, 2003.

  2. The GISS model of the global atmosphere. [Goddard Institute for Space Studies numerical model

    NASA Technical Reports Server (NTRS)

    Somerville, R. C. J.; Stone, P. H.; Halem, M.; Hansen, J. E.; Hogan, J. S.; Druyan, L. M.; Quirk, W. J.; Russell, G.; Lacis, A. A.; Tenenbaum, J.

    1974-01-01

    A description and numerical results are presented for a global atmospheric circulation model developed at the Goddard Institute for Space Studies (GISS). The model version described is a 9-level primitive-equation model in sigma coordinates. It includes a realistic distribution of continents, oceans and topography. Detailed calculations of energy transfer by solar and terrestrial radiation make use of cloud and water vapor fields calculated by the model. The model hydrologic cycle includes two precipitation mechanisms: large-scale supersaturation and a parameterization of subgrid-scale cumulus convection. Results are presented both from a comparison of the 13th to the 43rd days (January) of one integration with climatological statistics, and from five short-range forecasting experiments. In the extended integration, the near-equilibrium January-mean model atmosphere exhibits an energy cycle in good agreement with observational estimates, together with generally realistic zonal mean fields of winds, temperature, humidity, transports, diabatic heating, evaporation, precipitation, and cloud cover.

  3. Sky cover from MFRSR observations: cumulus clouds

    NASA Astrophysics Data System (ADS)

    Kassianov, E.; Barnard, J.; Berg, L. K.; Flynn, C.; Long, C. N.

    2011-01-01

    The diffuse all-sky surface irradiances measured at two nearby wavelengths in the visible spectral range and their model clear-sky counterparts are two main components of a new method for estimating the fractional sky cover of different cloud types, including cumulus clouds. The performance of this method is illustrated using 1-min resolution data from ground-based Multi-Filter Rotating Shadowband Radiometer (MFRSR). The MFRSR data are collected at the US Department of Energy Atmospheric Radiation Measurement (ARM) Climate Research Facility (ACRF) Southern Great Plains (SGP) site during the summer of 2007 and represent 13 days with cumulus clouds. Good agreement is obtained between estimated values of the fractional sky cover and those provided by a well-established independent method based on broadband observations.

  4. Response of cumulus clouds to large-scale forcing and cumulus parameterization

    NASA Technical Reports Server (NTRS)

    Ogura, Y.

    1985-01-01

    Using the cumulus ensemble model (Soong and Ogura, 1980), statistical properties of cumulus clouds that occur in response to the imposed large scale forcing were investigated both in the tropical and midlatitude situtations. A strong drying process was found to occur in the boundary layer in association with deep convection in a midlatitude case. The Arakawa-Schubert (1974) cumulus parameterization scheme was tested semi-prognostically against both the model result and the observation in a tropical rain event that occurred in GATE. The Cloud heating and drying effects predicted by the Arakawa-Schubert scheme were found to agree well both with the observation and the model result. However, it was also found that the Arakawa-Schuber scheme underestimates both condensation and evaporation rates substantially. An inclusion of the downdraft effect, as formulated by Johnson (1976), appears to alleviate this deficiency. This downdraft effect may be important in predicting the behavior of the boundary accurately.

  5. NASA Goddard and Minority Serving Institutions

    NASA Astrophysics Data System (ADS)

    Nall, J.

    2005-12-01

    NASA's Goddard Space Flight Center has worked closely with Minority Serving Institutions for many years. The presenter will detail specific approaches with selected institutions, or types of colleges to offer what has worked, and what has not, methodologies employed to engage students and faculty in our programs, and how such program development and collaboration have proven mutually beneficial. An interactive session with the audience will seek to encourage partnership connections at the conference.

  6. The Rocket Experiments of Robert H. Goddard, 1911 to 1930.

    ERIC Educational Resources Information Center

    Page, Brian R.

    1991-01-01

    Recounts the contributions of Robert Goddard from the years of 1911 to 1930 to the development of the physics of rocketry. Discusses the results of Goddard's series of rocket experiments endorsed by the Smithsonian Institute, and Goddard's claims to priority in the development of rocket theory. (MDH)

  7. Ozone conservation and entrainment in cumulus congestus

    NASA Technical Reports Server (NTRS)

    Pearson, R., Jr.; Weaver, C. J.

    1989-01-01

    This study demonstrates that ozone mixing ratio is conserved during moist convection and can be used as a tracer for cloud entrainment studies. The approach is to apply mixing line analysis to pairs of liquid water potential temperature, total water mixing ratio, O3 and pseudo-equivalent potential temperature derived from aircraft penetrations of growing cumulus congestus. Conclusions about entrainment from the mixing diagrams employing O3 agree with those using thermodynamic quantities. Any disagreement uncovered deficiencies in the water substance measurement technique.

  8. Cumulus cell-expressed type I interferons induce cumulus expansion in mice.

    PubMed

    Jang, You-Jee; Park, Jae-Il; Moon, Won-Jin; Dam, Phuong T M; Cho, Moon-Kyoung; Chun, Sang-Young

    2015-01-01

    Ovulation resembles the inflammatory response. The purpose of the present study was to examine the expression and role of type I interferons (IFNs) Ifnalpha and Ifnbeta in mouse ovaries during the process of ovulation. An in vivo injection of equine chorionic gonadotropin (CG)-human CG (hCG) stimulated Ifnalpha and Ifnbeta mRNA in cumulus-oocyte complexes (COCs) within 6 h. Type I IFN receptor (Ifnar1 and Ifnar2) genes were also expressed in preovulatory follicles without a change by hCG. Immunofluorescent study revealed the expression of protein signals of Ifnalpha, Ifnbeta, and Ifnar1 in cumulus cells. Treatment of COCs with Ifnalpha or Ifnbeta in vitro induced cumulus expansion that was comparable to that mediated by epiregulin. In cultured COCs, the levels of Ifnalpha and Ifnbeta mRNA increased by epiregulin and follicle-stimulating hormone, but not by prostaglandin E2. Ifnalpha and Ifnbeta activated multiple signaling events (signal transducer and activator of transcription-1/3, Akt, and mitogen-activated protein kinase 1/2) and stimulated the expression of genes known to impact COC expansion (Has2, Ptx3, Tnfaip6, and Ptgs2). Interestingly, treatment of COCs with Toll-like receptor (TLR) 2 and TLR4 ligands (lipopolysaccharides, Pam3Cys, and hyaluronan fragments) increased Ifnalpha and Ifnbeta mRNA, while coculture with anti-TLR2/4 neutralizing antibody abolished these effects. Taken together, these results demonstrate that the type I IFN system is operating in mouse cumulus cells and plays a role in the induction of cumulus expansion during the ovulatory process in mice. PMID:25429090

  9. Motility contrast imaging of live porcine cumulus-oocyte complexes

    NASA Astrophysics Data System (ADS)

    An, Ran; Turek, John; Machaty, Zoltan; Nolte, David

    2013-02-01

    Freshly-harvested porcine oocytes are invested with cumulus granulosa cells in cumulus-oocyte complexes (COCs). The cumulus cell layer is usually too thick to image the living oocyte under a conventional microscope. Therefore, it is difficult to assess the oocyte viability. The low success rate of implantation is the main problem for in vitro fertilization. In this paper, we demonstrate our dynamic imaging technique called motility contrast imaging (MCI) that provides a non-invasive way to monitor the COCs before and after maturation. MCI shows a change of intracellular activity during oocyte maturation, and a measures dynamic contrast between the cumulus granulosa shell and the oocytes. MCI also shows difference in the spectral response between oocytes that were graded into quality classes. MCI is based on shortcoherence digital holography. It uses intracellular motility as the endogenous imaging contrast of living tissue. MCI presents a new approach for cumulus-oocyte complex assessment.

  10. Remembering Robert Goddard's vision 100 years later

    NASA Astrophysics Data System (ADS)

    Stern, David P.

    “Life, liberty, and the pursuit of happiness” —such are the goals of most of us.Yet a few always exist who feel called by a higher purpose. Society often owes them a great deal.Robert Hutchins Goddard, whose work made spaceflight possible, found his vision 100 years ago this October as a youth of 17. His family was staying on the farm of a relative, when he was asked to trim the branches of a cherry tree behind the barn.

  11. Aniso2D

    2005-07-01

    Aniso2d is a two-dimensional seismic forward modeling code. The earth is parameterized by an X-Z plane in which the seismic properties Can have monoclinic with x-z plane symmetry. The program uses a user define time-domain wavelet to produce synthetic seismograms anrwhere within the two-dimensional media.

  12. Cloud condensation nuclei near marine cumulus

    NASA Technical Reports Server (NTRS)

    Hudson, James G.

    1993-01-01

    Extensive airborne measurements of cloud condensation nucleus (CCN) spectra and condensation nuclei below, in, between, and above the cumulus clouds near Hawaii point to important aerosol-cloud interactions. Consistent particle concentrations of 200/cu cm were found above the marine boundary layer and within the noncloudy marine boundary layer. Lower and more variable CCN concentrations within the cloudy boundary layer, especially very close to the clouds, appear to be a result of cloud scavenging processes. Gravitational coagulation of cloud droplets may be the principal cause of this difference in the vertical distribution of CCN. The results suggest a reservoir of CCN in the free troposphere which can act as a source for the marine boundary layer.

  13. Cumulus clouds - Numerical models, observations and entrainment

    NASA Technical Reports Server (NTRS)

    Simpson, J.

    1983-01-01

    The first computer simulation of the organization phase of a buoyant atmospheric thermal is described. Although crude, it showed the spontaneous development of a rounded tight-gradient 'cap' and internal vortical circulation. The complexities involved in these 'field of motion' models in part motivated the development of entity models, based upon laboratory thermals. These one-dimensional models and their uses with observations are briefly described as well as their limitations. Finally, an application of Schlesinger's three-dimensional model to a GATE cumulus situation clarifies many apparently conflicting observations and postulates, thereby raising further challenging questions to be addressed jointly by the more sophisticated measuring and modeling tools available in the 1980's.

  14. Cumulus cloud venting of mixed layer ozone

    NASA Technical Reports Server (NTRS)

    Ching, J. K. S.; Shipley, S. T.; Browell, E. V.; Brewer, D. A.

    1985-01-01

    Observations are presented which substantiate the hypothesis that significant vertical exchange of ozone and aerosols occurs between the mixed layer and the free troposphere during cumulus cloud convective activity. The experiments utilized the airborne Ultra-Violet Differential Absorption Lidar (UV-DIAL) system. This system provides simultaneous range resolved ozone concentration and aerosol backscatter profiles with high spatial resolution. Evening transects were obtained in the downwind area where the air mass had been advected. Space-height analyses for the evening flight show the cloud debris as patterns of ozone typically in excess of the ambient free tropospheric background. This ozone excess was approximately the value of the concentration difference between the mixed layer and free troposphere determined from independent vertical soundings made by another aircraft in the afternoon.

  15. Dr. Goddard and a 1918 version of 'Bazooka'

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Dr. Robert H. Goddard loading a 1918 version of the Bazooka of World War II. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  16. Research and Technology, 1987, Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Guerny, Gene (Editor); Moe, Karen (Editor); Paddack, Steven (Editor); Soffen, Gerald (Editor); Sullivan, Walter (Editor); Ballard, Jan (Editor)

    1987-01-01

    Research at Goddard Space Flight Center during 1987 is summarized. Topics addressed include space and earth sciences, technology, flight projects and mission definition studies, and institutional technology.

  17. Robert H. Goddard and His Liquid-Gasoline Rocket

    NASA Technical Reports Server (NTRS)

    1926-01-01

    Dr. Goddard's 1926 rocket configuration. Dr. Goddard's liquid oxygen-gasoline rocket was fired on March 16, 1926, at Auburn, Massachusetts. It flew for only 2.5 seconds, climbed 41 feet, and landed 184 feet away in a cabbage patch. From 1930 to 1941, Dr. Goddard made substantial progress in the development of progressively larger rockets, which attained altitudes of 2400 meters, and refined his equipment for guidance and control, his techniques of welding, and his insulation, pumps, and other associated equipment. In many respects, Dr. Goddard laid the essential foundations of practical rocket technology

  18. Mesh2d

    SciTech Connect

    Greg Flach, Frank Smith

    2011-12-31

    Mesh2d is a Fortran90 program designed to generate two-dimensional structured grids of the form [x(i),y(i,j)] where [x,y] are grid coordinates identified by indices (i,j). The x(i) coordinates alone can be used to specify a one-dimensional grid. Because the x-coordinates vary only with the i index, a two-dimensional grid is composed in part of straight vertical lines. However, the nominally horizontal y(i,j0) coordinates along index i are permitted to undulate or otherwise vary. Mesh2d also assigns an integer material type to each grid cell, mtyp(i,j), in a user-specified manner. The complete grid is specified through three separate input files defining the x(i), y(i,j), and mtyp(i,j) variations.

  19. Mesh2d

    2011-12-31

    Mesh2d is a Fortran90 program designed to generate two-dimensional structured grids of the form [x(i),y(i,j)] where [x,y] are grid coordinates identified by indices (i,j). The x(i) coordinates alone can be used to specify a one-dimensional grid. Because the x-coordinates vary only with the i index, a two-dimensional grid is composed in part of straight vertical lines. However, the nominally horizontal y(i,j0) coordinates along index i are permitted to undulate or otherwise vary. Mesh2d also assignsmore » an integer material type to each grid cell, mtyp(i,j), in a user-specified manner. The complete grid is specified through three separate input files defining the x(i), y(i,j), and mtyp(i,j) variations.« less

  20. Science at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    White, Nicholas E.

    2012-01-01

    The Sciences and Exploration Directorate of the NASA Goddard Space Flight Center (GSFC) is the largest Earth and space science research organization in the world. Its scientists advance understanding of the Earth and its life-sustaining environment, the Sun, the solar system, and the wider universe beyond. Researchers in the Sciences and Exploration Directorate work with engineers, computer programmers, technologists, and other team members to develop the cutting-edge technology needed for space-based research. Instruments are also deployed on aircraft, balloons, and Earth's surface. I will give an overview of the current research activities and programs at GSFC including the James Web Space Telescope (JWST), future Earth Observing programs, experiments that are exploring our solar system and studying the interaction of the Sun with the Earth's magnetosphere.

  1. Geometrical geodesy techniques in Goddard earth models

    NASA Technical Reports Server (NTRS)

    Lerch, F. J.

    1974-01-01

    The method for combining geometrical data with satellite dynamical and gravimetry data for the solution of geopotential and station location parameters is discussed. Geometrical tracking data (simultaneous events) from the global network of BC-4 stations are currently being processed in a solution that will greatly enhance of geodetic world system of stations. Previously the stations in Goddard earth models have been derived only from dynamical tracking data. A linear regression model is formulated from combining the data, based upon the statistical technique of weighted least squares. Reduced normal equations, independent of satellite and instrumental parameters, are derived for the solution of the geodetic parameters. Exterior standards for the evaluation of the solution and for the scale of the earth's figure are discussed.

  2. Vertical 2D Heterostructures

    NASA Astrophysics Data System (ADS)

    Lotsch, Bettina V.

    2015-07-01

    Graphene's legacy has become an integral part of today's condensed matter science and has equipped a whole generation of scientists with an armory of concepts and techniques that open up new perspectives for the postgraphene area. In particular, the judicious combination of 2D building blocks into vertical heterostructures has recently been identified as a promising route to rationally engineer complex multilayer systems and artificial solids with intriguing properties. The present review highlights recent developments in the rapidly emerging field of 2D nanoarchitectonics from a materials chemistry perspective, with a focus on the types of heterostructures available, their assembly strategies, and their emerging properties. This overview is intended to bridge the gap between two major—yet largely disjunct—developments in 2D heterostructures, which are firmly rooted in solid-state chemistry or physics. Although the underlying types of heterostructures differ with respect to their dimensions, layer alignment, and interfacial quality, there is common ground, and future synergies between the various assembly strategies are to be expected.

  3. NASA/Goddard Thermal Technology Overview 2014

    NASA Technical Reports Server (NTRS)

    Butler, Daniel; Swanson, Theodore D.

    2014-01-01

    This presentation summarizes the current plans and efforts at NASA Goddard to develop new thermal control technology for anticipated future missions. It will also address some of the programmatic developments currently underway at NASA, especially with respect to the Technology Development Program at NASA. While funding for basic technology development is still scarce, significant efforts are being made in direct support of flight programs. New technology development continues to be driven by the needs of future missions, and applications of these technologies to current Goddard programs will be addressed. Many of these technologies also have broad applicability to DOD, DOE, and commercial programs. Partnerships have been developed with the Air Force, Navy, and various universities to promote technology development. In addition, technology development activities supported by internal research and development (IRAD) program, the Small Business Innovative Research (SBIR) program, and the NASA Engineering and Safety Center (NESC), are reviewed in this presentation. Specific technologies addressed include; two-phase systems applications and issues on NASA missions, latest developments of electro-hydrodynamically pumped systems, development of high electrical conductivity coatings, and various other research activities. New Technology program underway at NASA, although funding is limited center dot NASA/GSFC's primary mission of science satellite development is healthy and vibrant, although new missions are scarce - now have people on overhead working new missions and proposals center dot Future mission applications promise to be thermally challenging center dot Direct technology funding is still very restricted - Projects are the best source for direct application of technology - SBIR thermal subtopic resurrected in FY 14 - Limited Technology development underway via IRAD, NESC, other sources - Administrator pushing to revive technology and educational programs at NASA

  4. Simulation of solar radiative transfer in cumulus clouds

    SciTech Connect

    Zuev, V.E.; Titov, G.A.

    1996-04-01

    This work presents a 3-D model of radiative transfer which is used to study the relationship between the spatial distribution of cumulus clouds and fluxes (albedo and transmittance) of visible solar radiation.

  5. Determination of the cumulus size distribution from LANDSAT pictures

    NASA Technical Reports Server (NTRS)

    Karg, E.; Mueller, H.; Quenzel, H.

    1983-01-01

    Varying insolation causes undesirable thermic stress to the receiver of a solar power plant. The rapid change of insolation depends on the size distribution of the clouds; in order to measure these changes, it is suitable to determine typical cumulus size distributions. For this purpose, LANDSAT-images are adequate. Several examples of cumulus size distributions will be presented and their effects on the operation of a solar power plant are discussed.

  6. Apoptosis of postovulatory cumulus granulosa cells of the rat.

    PubMed

    Szołtys, M; Tabarowski, Z; Pawlik, A

    2000-12-01

    The process of apoptosis in the postovulatory cumulus granulosa cells was investigated in pregnant rats. Mature female Wistar rats, exhibiting a regular 4-day oestrous cycle, were placed with males on the day of pro-oestrus. The following day, on which spermatozoa were found in vaginal smears, was designated day 1 of pregnancy. The animals were killed just before ovulation (24.00 hours), on days 1 (5.00, 11.00, and 18.00 hours), and 2 ( 11.00 hours) of pregnancy. Excised ovaries and oviducts were submitted to a routine histological procedure and paraplast sections were subjected to detection of apoptotic cells using the TUNEL method. The cumulus granulosa cells of preovulatory follicles (24.00 hours) were negative for apoptotic staining. However, 5 h later a positive staining was observed in the oviduct ampulla and included the cumulus granulosa cells lying in the peripheral parts of postovulatory cumuli oophori, and the oviductal epithelial cells of this region. On the evening of day 1 almost all cumulus granulosa cells showed strong immunostaining while on day 2 at 11.00 hours only immunonegative clusters of remnants of cumulus granulosa cells were present in the distended ampulla region, while naked, two or more cell embryos were present in the further parts of oviduct. These results indicate that in the rat apoptosis of cumulus granulosa cells starts shortly after ovulation in the peripheral region. Epithelial ampullary cells surrounding ovulated cumuli show a massive apoptosis. PMID:11131018

  7. The 1993 Goddard Conference on Space Applications of Artificial Intelligence

    NASA Technical Reports Server (NTRS)

    Hostetter, Carl F. (Editor)

    1993-01-01

    This publication comprises the papers presented at the 1993 Goddard Conference on Space Applications of Artificial Intelligence held at the NASA/Goddard Space Flight Center, Greenbelt, MD on May 10-13, 1993. The purpose of this annual conference is to provide a forum in which current research and development directed at space applications of artificial intelligence can be presented and discussed.

  8. First radar echoes from cumulus clouds

    NASA Technical Reports Server (NTRS)

    Knight, Charles A.; Miller, L. J.

    1993-01-01

    In attempting to use centimeter-wavelength radars to investigate the early stage of precipitation formation in clouds, 'mantle echoes' are rediscovered and shown to come mostly from scattering by small-scale variations in refractive index, a Bragg kind of scattering mechanism. This limits the usefulness of single-wavelength radar for studies of hydrometeor growth, according to data on summer cumulus clouds in North Dakota, Hawaii, and Florida, to values of reflectivity factor above about 10 dBZe with 10-cm radar, 0 dBZe with 5-cm radar, and -10 dBZe with 3-cm radar. These are limits at or above which the backscattered radar signal from the kinds of clouds observed can be assumed to be almost entirely from hydrometeors or (rarely) other particulate material such as insects. Dual-wavelength radar data can provide the desired information about hydrometeors at very low reflectivity levels if assumptions can be made about the inhomogeneities responsible for the Bragg scattering. The Bragg scattering signal itself probably will be a useful way to probe inhomogeneities one-half the radar wavelength in scale for studying cloud entrainment and mixing processes. However, this use is possible only before scattering from hydrometeors dominates the radar return.

  9. Transcriptomic analysis of cyclic AMP response in bovine cumulus cells.

    PubMed

    Khan, D R; Guillemette, C; Sirard, M A; Richard, F J

    2015-09-01

    Acquisition of oocyte developmental competence needs to be understood to improve clinical outcomes of assisted reproduction. The stimulation of cumulus cell concentration of cyclic adenosine 3'5'-monophosphate (cAMP) by pharmacological agents during in vitro maturation (IVM) participates in improvement of oocyte quality. However, precise coordination and downstream targets of cAMP signaling in cumulus cells are largely unknown. We have previously demonstrated better embryo development after cAMP stimulation for first 6 h during IVM. Using this model, we investigated cAMP signaling in cumulus cells through in vitro culture of cumulus-oocyte complexes (COCs) in the presence of cAMP raising agents: forskolin, IBMX, and dipyridamole (here called FID treatment). Transcriptomic analysis of cumulus cells indicated that FID-induced differentially expressed transcripts were implicated in cumulus expansion, steroidogenesis, cell metabolism, and oocyte competence. Functional genomic analysis revealed that protein kinase-A (PKA), extracellular signal regulated kinases (ERK1/2), and calcium (Ca(2+)) pathways as key regulators of FID signaling. Inhibition of PKA (H89) in FID-supplemented COCs or substitution of FID with calcium ionophore (A23187) demonstrated that FID activated primarily the PKA pathway which inhibited ERK1/2 phosphorylation and was upstream of calcium signaling. Furthermore, inhibition of ERK1/2 phosphorylation by FID supported a regulation by dual specific phosphatase (DUSP1) via PKA. Our findings imply that cAMP (FID) regulates cell metabolism, steroidogenesis, intracellular signaling and cumulus expansion through PKA which modulates these functions through optimization of ERK1/2 phosphorylation and coordination of calcium signaling. These findings have implications for development of new strategies for improving oocyte in vitro maturation leading to better developmental competence. PMID:26082143

  10. Goddard's Astrophysics Science Division Annual Report 2013

    NASA Technical Reports Server (NTRS)

    Weaver, Kimberly A. (Editor); Reddy, Francis J. (Editor); Tyler, Patricia A. (Editor)

    2014-01-01

    The Astrophysics Science Division (ASD) at Goddard Space Flight Center (GSFC) is one of the largest and most diverse astrophysical organizations in the world, with activities spanning a broad range of topics in theory, observation, and mission and technology development. Scientific research is carried out over the entire electromagnetic spectrum from gamma rays to radio wavelengths as well as particle physics and gravitational radiation. Members of ASD also provide the scientific operations for two orbiting astrophysics missions Fermi Gamma-ray Space Telescope and Swift as well as the Science Support Center for Fermi. A number of key technologies for future missions are also under development in the Division, including X-ray mirrors, space-based interferometry, high contrast imaging techniques to search for exoplanets, and new detectors operating at gamma-ray, X-ray, ultraviolet, infrared, and radio wavelengths. The overriding goals of ASD are to carry out cutting-edge scientific research, provide Project Scientist support for spaceflight missions, implement the goals of the NASA Strategic Plan, serve and support the astronomical community, and enable future missions by conceiving new concepts and inventing new technologies.

  11. Goddard's Astrophysics Science Division Annual Report 2011

    NASA Technical Reports Server (NTRS)

    Centrella, Joan; Reddy, Francis; Tyler, Pat

    2012-01-01

    The Astrophysics Science Division(ASD) at Goddard Space Flight Center(GSFC)is one of the largest and most diverse astrophysical organizations in the world, with activities spanning a broad range of topics in theory, observation, and mission and technology development. Scientific research is carried out over the entire electromagnetic spectrum from gamma rays to radiowavelengths as well as particle physics and gravitational radiation. Members of ASD also provide the scientific operations for three orbiting astrophysics missions WMAP, RXTE, and Swift, as well as the Science Support Center for the Fermi Gamma-ray Space Telescope. A number of key technologies for future missions are also under development in the Division, including X-ray mirrors, space-based interferometry, high contract imaging techniques to serch for exoplanets, and new detectors operating at gamma-ray, X-ray, ultraviolet, infrared, and radio wavelengths. The overriding goals of ASD are to carry out cutting-edge scientific research, and provide Project Scientist support for spaceflight missions, implement the goals of the NASA Strategic Plan, serve and suppport the astronomical community, and enable future missions by conceiving new conepts and inventing new technologies.

  12. Response of Cumulus Clouds to Large-Scale Forcing Using the Arakawa-Schubert Cumulus Parameterization.

    NASA Astrophysics Data System (ADS)

    Kao, Chih-Yue Jim; Ogura, Yoshi

    1987-09-01

    A cumulus parameterization scheme developed by Arakawa and Schubert was tested through a semiprognostic approach using two different datasets: one for a tropical cloud band, the other for tropical composite easterly wave disturbances. Both were observed in GARP (Global Atmospheric Research Program) Atlantic Tropical Experiment using a computational algorithm different from that of Lord. Also, an efficient software package from the International Mathematics and Statistics Library was used in determining the cloud mass flux at the cloud base level.The semiprognostic results indicate that the cloud heating and drying effects predicted by the Arakawa-Schubert scheme in both cases agree rather well with the observations. Also, the predicted cloud population in terms of cloud-base mass flux shows the prominent features as already revealed by other previous diagnostic studies in the tropical area. The Arakawa-Schubert scheme underestimates both condensation and evaporation rates substantially when compared with the cumulus ensemble model results for the cloud band case by Soong and Tao and another subsequent case by Tao. An inclusion of the downdraft effects associated with the evaporation of rainfall appears to alleviate this deficiency.

  13. Immature oocyte quality and maturational competence of porcine cumulus-oocyte complexes subpopulations.

    PubMed

    Alvarez, Gabriel Martin; Dalvit, Gabriel Carlos; Achi, María Verónica; Miguez, Marcelo Sergio; Cetica, Pablo Daniel

    2009-12-01

    Porcine immature oocyte quality (i.e., that of live oocytes at the germinal vesicle stage) was evaluated according to features of the surrounding cumulus, aiming to establish maturational competence of different subpopulations of such cumulus-oocyte complexes. Six subpopulations were identified: A1 (with a dense cumulus), A2 (with a translucent cumulus), B1 (with the corona radiata), B2 (partly naked oocytes), C (naked oocytes), D (with a dark cumulus). The percent incidence of live oocyte in these subpopulations changed significantly as related to cumulus features, however the occurrence of oocytes in the germinal vesicle stage was lower in class D only. Similar metaphase II rates achieved in A1, A2, B1 and B2 classes after in vitro maturation suggest that the nucleus may in fact mature in vitro, in spite of the different accompanying cumulus features which are typical of these classes. In contrast, a higher cytoplasmic maturation rate obtained in class A may indicate a stronger dependence of this variable upon cumulus features than that shown by nuclear maturation. When different types of cumulus expansion after in vitro maturation were considered (i.e., fully expanded cumulus, partly expanded cumulus, and partly naked oocyte), no differences were found in the percent of oocytes reaching metaphase II or cytoplasmic maturation. It is concluded that morphological features of the collected porcine cumulus-oocyte complexes (rather than cumulus behavior during culture) may be useful for selection of potentially competent oocytes for in vitro fertilization and embryo production. PMID:20067032

  14. Satellite-tracked cumulus velocities. [for determining wind velocity

    NASA Technical Reports Server (NTRS)

    Fujita, T. T.; Pearl, E. W.; Shenk, W. E.

    1973-01-01

    The research indicates that extreme caution must be exercised in converting cloud velocities into winds. The motion of fair-weather cumuli obtained by tracking their shadows over Springfield, Missouri revealed that the standard deviation in the individual cloud motion is several times the tracking error. The motion of over-ocean cumuli near Barbados clearly indicated the complicated nature of cumulus velocities. Analysis of whole-sky images obtained near Tampa, Florida failed to show significant continuity and stability of cumulus plumes, less than 0.3 mile in diameter. Cumulus turrets with 0.3 to 2 mile in size appear to be the best target to infer the mean wind within the subcloud layers. Cumulus or stratocumulus cells consisting of x number of turrets do not always move with wind. The addition and deletion of turrets belonging to a specific cell appear to be the cause of the erratic motion of a tracer cell. It may by concluded that the accuracy of wind estimates is unlikely to be better than 2m/sec unless the physical and dynamical characteristics of cumulus motion is futher investigated.

  15. Derivation of Cumulus Cloud Dimensions and Shape from the Airborne Measurements by the Research Scanning Polarimeter

    NASA Technical Reports Server (NTRS)

    Alexandrov, Mikhail D.; Cairns, Brian; Emde, Claudia; Ackerman, Andrew S.; Ottaviani, Matteo; Wasilewski, Andrzej P.

    2016-01-01

    The Research Scanning Polarimeter (RSP) is an airborne instrument, whose measurements have been extensively used for retrievals of microphysical properties of clouds. In this study we show that for cumulus clouds the information content of the RSP data can be extended by adding the macroscopic parameters of the cloud, such as its geometric shape, dimensions, and height above the ground. This extension is possible by virtue of the high angular resolution and high frequency of the RSP measurements, which allow for geometric constraint of the cloud's 2D cross section between a number of tangent lines of view. The retrieval method is tested on realistic 3D radiative transfer simulations and applied to actual RSP data.

  16. ISS Update: NBL Orion Flight Lead Tim Goddard

    NASA Video Gallery

    NASA Public Affairs Officer Brandi Dean talks with Tim Goddard, Neutral Buoyancy Laboratory (NBL) Orion Flight Lead, about how the NBL is used to train rescue and recovery personnel for future Orio...

  17. The Goddard Space Flight Center preferred parts list, revision A

    NASA Technical Reports Server (NTRS)

    Tyson, N. E. (Editor)

    1982-01-01

    A listing is presented of preferred electronic parts, part upgrading procedures, part derating guidelines, and part screening procedures to be used in the selection, procurement, and application of parts for Goddard Space Flight Center space systems and ground support equipment.

  18. Hubble 25th Anniversary: NASA Social at Goddard

    NASA Video Gallery

    NASA's Hubble Space Telescope celebrated its 25th anniversary on April 24, 2015. To mark the occasion, NASA's Goddard Space Flight Center in Greenbelt, Maryland -- home of Hubble operations -- host...

  19. The beneficial effects of cumulus cells and oocyte-cumulus cell gap junctions depends on oocyte maturation and fertilization methods in mice

    PubMed Central

    Zhou, Cheng-Jie; Wu, Sha-Na; Shen, Jiang-Peng; Wang, Dong-Hui; Kong, Xiang-Wei; Lu, Angeleem; Li, Yan-Jiao; Zhou, Hong-Xia; Zhao, Yue-Fang

    2016-01-01

    Cumulus cells are a group of closely associated granulosa cells that surround and nourish oocytes. Previous studies have shown that cumulus cells contribute to oocyte maturation and fertilization through gap junction communication. However, it is not known how this gap junction signaling affects in vivo versus in vitro maturation of oocytes, and their subsequent fertilization and embryonic development following insemination. Therefore, in our study, we performed mouse oocyte maturation and insemination using in vivo- or in vitro-matured oocyte-cumulus complexes (OCCs, which retain gap junctions between the cumulus cells and the oocytes), in vitro-matured, denuded oocytes co-cultured with cumulus cells (DCs, which lack gap junctions between the cumulus cells and the oocytes), and in vitro-matured, denuded oocytes without cumulus cells (DOs). Using these models, we were able to analyze the effects of gap junction signaling on oocyte maturation, fertilization, and early embryo development. We found that gap junctions were necessary for both in vivo and in vitro oocyte maturation. In addition, for oocytes matured in vivo, the presence of cumulus cells during insemination improved fertilization and blastocyst formation, and this improvement was strengthened by gap junctions. Moreover, for oocytes matured in vitro, the presence of cumulus cells during insemination improved fertilization, but not blastocyst formation, and this improvement was independent of gap junctions. Our results demonstrate, for the first time, that the beneficial effect of gap junction signaling from cumulus cells depends on oocyte maturation and fertilization methods. PMID:26966678

  20. Advancing Models and Evaluation of Cumulus, Climate and Aerosol Interactions

    SciTech Connect

    Gettelman, Andrew

    2015-10-27

    This project was successfully able to meet its’ goals, but faced some serious challenges due to personnel issues. Nonetheless, it was largely successful. The Project Objectives were as follows: 1. Develop a unified representation of stratifom and cumulus cloud microphysics for NCAR/DOE global community models. 2. Examine the effects of aerosols on clouds and their impact on precipitation in stratiform and cumulus clouds. We will also explore the effects of clouds and precipitation on aerosols. 3. Test these new formulations using advanced evaluation techniques and observations and release

  1. Momentum Transport by Cumulus Clouds and its Parameterization.

    NASA Astrophysics Data System (ADS)

    Zhang, Guang Jun

    The effect of cumulus convection on the large -scale momentum field is examined in this thesis. A parameterization scheme is developed to calculate the vertical transport of momentum by cumulus clouds. The effect of the perturbation pressure field induced by cumulus convection on the cloud momentum and its vertical transport is taken into account for the first time. It is shown that a perturbation pressure field is required to balance the irrotational component of the local Coriolis force produced by the interaction of the large-scale flow field with the cumulus-scale circulation. To facilitate quantitative evaluation of the horizontal pressure gradient force across the cloud, a simple cloud model which specifies the dynamic and the thermodynamic structures in cloud is developed. The parameterization scheme is applied to several convective events in the tropics and the midlatitudes. The first case is the average of six convective periods observed in Phase III of GATE. The second one is the numerical simulation of a convective band observed in Phase II of GATE by Soong and Tao (1984). It is shown that the cloud mean wind obtained from the parameterization scheme changes significantly with height if the environmental wind has strong vertical shear. The perturbation pressure gradient force across the cloud plays an important role in changing the cloud mean momentum. The vertical transport of the horizontal momentum by cumulus clouds is parameterized and compared to observations and numerical simulations. Good agreement is found between the computed and the observed/simulated cumulus effects on the momentum field in both cases. The third case is a mesoscale convective complex observed in PRE-STORM. The evolution of the storm is analyzed; and the dynamic and the thermodynamic budgets are computed. Comparison between the residuals of the momentum budgets and the cumulus effects from the parameterization again shows good agreement. Sensitivity tests are performed to

  2. Goddard's Astrophysics Science Divsion Annual Report 2014

    NASA Technical Reports Server (NTRS)

    Weaver, Kimberly (Editor); Reddy, Francis (Editor); Tyler, Pat (Editor)

    2015-01-01

    The Astrophysics Science Division (ASD, Code 660) is one of the world's largest and most diverse astronomical organizations. Space flight missions are conceived, built and launched to observe the entire range of the electromagnetic spectrum, from gamma rays to centimeter waves. In addition, experiments are flown to gather data on high-energy cosmic rays, and plans are being made to detect gravitational radiation from space-borne missions. To enable these missions, we have vigorous programs of instrument and detector development. Division scientists also carry out preparatory theoretical work and subsequent data analysis and modeling. In addition to space flight missions, we have a vibrant suborbital program with numerous sounding rocket and balloon payloads in development or operation. The ASD is organized into five labs: the Astroparticle Physics Lab, the X-ray Astrophysics Lab, the Gravitational Astrophysics Lab, the Observational Cosmology Lab, and the Exoplanets and Stellar Astrophysics Lab. The High Energy Astrophysics Science Archive Research Center (HEASARC) is an Office at the Division level. Approximately 400 scientists and engineers work in ASD. Of these, 80 are civil servant scientists, while the rest are resident university-based scientists, contractors, postdoctoral fellows, graduate students, and administrative staff. We currently operate the Swift Explorer mission and the Fermi Gamma-ray Space Telescope. In addition, we provide data archiving and operational support for the XMM mission (jointly with ESA) and the Suzaku mission (with JAXA). We are also a partner with Caltech on the NuSTAR mission. The Hubble Space Telescope Project is headquartered at Goddard, and ASD provides Project Scientists to oversee operations at the Space Telescope Science Institute. Projects in development include the Neutron Interior Composition Explorer (NICER) mission, an X-ray timing experiment for the International Space Station; the Transiting Exoplanet Sky Survey (TESS

  3. Evaluation of a New Parameterization for Fair-Weather Cumulus

    SciTech Connect

    Berg, Larry K.; Stull, Roland B.

    2006-05-25

    A new parameterization for boundary layer cumulus clouds, called the cumulus potential (CuP) scheme, is introduced. This scheme uses joint probability density functions (JPDFs) of virtual potential temperature and water-vapor mixing ratio, as well as the mean vertical profiles of virtual potential temperature, to predict the amount and size distribution of boundary layer cloud cover. This model considers the diversity of air parcels over a heterogeneous surface, and recognizes that some parcels rise above their lifting condensation level to become cumulus, while other parcels might rise as clear updrafts. This model has several unique features: 1) surface heterogeneity is represented using the boundary layer JPDF of virtual potential temperature versus water-vapor mixing ratio, 2) clear and cloudy thermals are allowed to coexist at the same altitude, and 3) a range of cloud-base heights, cloud-top heights, and cloud thicknesses are predicted within any one cloud field, as observed. Using data from Boundary Layer Experiment 1996 and a model intercomparsion study using large eddy simulation (LES) based on Barbados Oceanographic and Meteorological Experiment (BOMEX), it is shown that the CuP model does a good job predicting cloud-base height and cloud-top height. The model also shows promise in predicting cloud cover, and is found to give better cloud-cover estimates than three other cumulus parameterizations: one based on relative humidity, a statistical scheme based on the saturation deficit, and a slab model.

  4. Cumulus clouds - Early aircraft observations and entrainment hypotheses

    NASA Technical Reports Server (NTRS)

    Simpson, J.

    1983-01-01

    The history of cumulus research in the decade following World War II is reviewed in the perspective of the new ideas and advances made during the subsequent generation. Emphasis is placed upon pioneering aircraft measurements, evidence for entrainment, the early model attempts and their attendant controversies.

  5. Cumulus parameterizations in chemical transport models

    NASA Astrophysics Data System (ADS)

    Mahowald, Natalie M.; Rasch, Philip J.; Prinn, Ronald G.

    1995-12-01

    Global three-dimensional chemical transport models (CTMs) are valuable tools for studying processes controlling the distribution of trace constituents in the atmosphere. A major uncertainty in these models is the subgrid-scale parametrization of transport by cumulus convection. This study seeks to define the range of behavior of moist convective schemes and point toward more reliable formulations for inclusion in chemical transport models. The emphasis is on deriving convective transport from meteorological data sets (such as those from the forecast centers) which do not routinely include convective mass fluxes. Seven moist convective parameterizations are compared in a column model to examine the sensitivity of the vertical profile of trace gases to the parameterization used in a global chemical transport model. The moist convective schemes examined are the Emanuel scheme [Emanuel, 1991], the Feichter-Crutzen scheme [Feichter and Crutzen, 1990], the inverse thermodynamic scheme (described in this paper), two versions of a scheme suggested by Hack [Hack, 1994], and two versions of a scheme suggested by Tiedtke (one following the formulation used in the ECMWF (European Centre for Medium-Range Weather Forecasting) and ECHAM3 (European Centre and Hamburg Max-Planck-Institut) models [Tiedtke, 1989], and one formulated as in the TM2 (Transport Model-2) model (M. Heimann, personal communication, 1992). These convective schemes vary in the closure used to derive the mass fluxes, as well as the cloud model formulation, giving a broad range of results. In addition, two boundary layer schemes are compared: a state-of-the-art nonlocal boundary layer scheme [Holtslag and Boville, 1993] and a simple adiabatic mixing scheme described in this paper. Three tests are used to compare the moist convective schemes against observations. Although the tests conducted here cannot conclusively show that one parameterization is better than the others, the tests are a good measure of the

  6. High divergent 2D grating

    NASA Astrophysics Data System (ADS)

    Wang, Jin; Ma, Jianyong; Zhou, Changhe

    2014-11-01

    A 3×3 high divergent 2D-grating with period of 3.842μm at wavelength of 850nm under normal incidence is designed and fabricated in this paper. This high divergent 2D-grating is designed by the vector theory. The Rigorous Coupled Wave Analysis (RCWA) in association with the simulated annealing (SA) is adopted to calculate and optimize this 2D-grating.The properties of this grating are also investigated by the RCWA. The diffraction angles are more than 10 degrees in the whole wavelength band, which are bigger than the traditional 2D-grating. In addition, the small period of grating increases the difficulties of fabrication. So we fabricate the 2D-gratings by direct laser writing (DLW) instead of traditional manufacturing method. Then the method of ICP etching is used to obtain the high divergent 2D-grating.

  7. Ground-Based Remote Retrievals of Cumulus Entrainment Rates

    SciTech Connect

    Wagner, Timothy J.; Turner, David D.; Berg, Larry K.; Krueger, Steven K.

    2013-07-26

    While fractional entrainment rates for cumulus clouds have typically been derived from airborne observations, this limits the size and scope of available data sets. To increase the number of continental cumulus entrainment rate observations available for study, an algorithm for retrieving them from ground-based remote sensing observations has been developed. This algorithm, called the Entrainment Rate In Cumulus Algorithm (ERICA), uses the suite of instruments at the Southern Great Plains (SGP) site of the United States Department of Energy's Atmospheric Radiation Measurement (ARM) Climate Research Facility as inputs into a Gauss-Newton optimal estimation scheme, in which an assumed guess of the entrainment rate is iteratively adjusted through intercomparison of modeled liquid water path and cloud droplet effective radius to their observed counterparts. The forward model in this algorithm is the Explicit Mixing Parcel Model (EMPM), a cloud parcel model that treats entrainment as a series of discrete entrainment events. A quantified value for measurement uncertainty is also returned as part of the retrieval. Sensitivity testing and information content analysis demonstrate the robust nature of this method for retrieving accurate observations of the entrainment rate without the drawbacks of airborne sampling. Results from a test of ERICA on three months of shallow cumulus cloud events show significant variability of the entrainment rate of clouds in a single day and from one day to the next. The mean value of 1.06 km-¹ for the entrainment rate in this dataset corresponds well with prior observations and simulations of the entrainment rate in cumulus clouds.

  8. High-Resolution NU-WRF Simulations of a Deep Convective-Precipitation System During MC3E. Part 1; Comparisons Between Goddard Microphysics Schemes and Observations

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo; Wu, Di; Lang, Stephen; Chern, Jiundar; Peters-Lidard, Christa; Fridlind, Ann; Matsui, Toshihisa

    2015-01-01

    The Goddard microphysics scheme was recently improved by adding a 4th ice class (frozen dropshail). This new 4ICE scheme was implemented and tested in the Goddard Cumulus Ensemble model (GCE) for an intense continental squall line and a moderate,less-organized continental case. Simulated peak radar reflectivity profiles were improved both in intensity and shape for both cases as were the overall reflectivity probability distributions versus observations. In this study, the new Goddard 4ICE scheme is implemented into the regional-scale NASA Unified - Weather Research and Forecasting model (NU-WRF) and tested on an intense mesoscale convective system that occurred during the Midlatitude Continental Convective Clouds Experiment (MC3E). The NU42WRF simulated radar reflectivities, rainfall intensities, and vertical and horizontal structure using the new 4ICE scheme agree as well as or significantly better with observations than when using previous versions of the Goddard 3ICE (graupel or hail) schemes. In the 4ICE scheme, the bin microphysics-based rain evaporation correction produces more erect convective cores, while modification of the unrealistic collection of ice by dry hail produces narrow and intense cores, allowing more slow-falling snow to be transported rearward. Together with a revised snow size mapping, the 4ICE scheme produces a more horizontally stratified trailing stratiform region with a broad, more coherent light rain area. In addition, the NU-WRF 4ICE simulated radar reflectivity distributions are consistent with and generally superior to those using the GCE due to the less restrictive open lateral boundaries

  9. High-resolution NU-WRF simulations of a deep convective-precipitation system during MC3E: Further improvements and comparisons between Goddard microphysics schemes and observations

    NASA Astrophysics Data System (ADS)

    Tao, Wei-Kuo; Wu, Di; Lang, Stephen; Chern, Jiun-Dar; Peters-Lidard, Christa; Fridlind, Ann; Matsui, Toshihisa

    2016-02-01

    The Goddard microphysics was recently improved by adding a fourth ice class (frozen drops/hail). This new 4ICE scheme was developed and tested in the Goddard Cumulus Ensemble (GCE) model for an intense continental squall line and a moderate, less organized continental case. Simulated peak radar reflectivity profiles were improved in intensity and shape for both cases, as were the overall reflectivity probability distributions versus observations. In this study, the new Goddard 4ICE scheme is implemented into the regional-scale NASA Unified-Weather Research and Forecasting (NU-WRF) model, modified and evaluated for the same intense squall line, which occurred during the Midlatitude Continental Convective Clouds Experiment (MC3E). NU-WRF simulated radar reflectivities, total rainfall, propagation, and convective system structures using the 4ICE scheme modified herein agree as well as or significantly better with observations than the original 4ICE and two previous 3ICE (graupel or hail) versions of the Goddard microphysics. With the modified 4ICE, the bin microphysics-based rain evaporation correction improves propagation and in conjunction with eliminating the unrealistic dry collection of ice/snow by hail can replicate the erect, narrow, and intense convective cores. Revisions to the ice supersaturation, ice number concentration formula, and snow size mapping, including a new snow breakup effect, allow the modified 4ICE to produce a stronger, better organized system, more snow, and mimic the strong aggregation signature in the radar distributions. NU-WRF original 4ICE simulated radar reflectivity distributions are consistent with and generally superior to those using the GCE due to the less restrictive domain and lateral boundaries.

  10. [Activities of Goddard Earth Sciences and Technology Center, Maryland University

    NASA Technical Reports Server (NTRS)

    2003-01-01

    The Goddard Space Flight Center (GSFC) is recognized as a world leader in the application of remote sensing and modeling aimed at improving knowledge of the Earth system. The Goddard Earth Sciences Directorate plays a central role in NASA's Earth Observing System and the U.S. Global Change Research Program. Goddard Earth Sciences and Technology (GEST) is organized as a cooperative agreement with the GSFC to promote excellence in the Earth sciences, and is a consortium of universities and corporations (University of Maryland Baltimore County, Howard University, Hampton University, Caelum Research Corporation and Northrop Grumman Corporation). The aim of this new program is to attract and introduce promising students in their first or second year of graduate studies to Oceanography and Earth system science career options through hands-on instrumentation research experiences on coastal processes at NASA's Wallops Flight Facility on the Eastern Shore of Virginia.

  11. Entrainment rates at the tops of laboratory analogs of cumulus and stratocumulus clouds

    NASA Astrophysics Data System (ADS)

    Górska, Anna; Malinowski, Szymon P.; Fugal, Jacob

    2015-04-01

    We investigate entrainment at tops of laboratory analogs of convective clouds: cumulus and stratocumulus. Cloudy saturated moist air (T ~22 °C) containing droplets of diameters of ~3-10 μm, is introduced into a laboratory cloud chamber of dimensions of 1.0×1.0×1.8 through an opening in the bottom wall. Initialy cloudy air fills ~60 cm thick layer at the bottom. Mixing between the cloud and unsaturated air above (T ~22 °C, RH ~35 %) results in evaporative cooling triggering convection which, in turn, leads to formation of a well mixed layer capperd with a temperature inversion. The temperature jump is about 2 °C within ~30 cm deep layer. Then updrafts are forced through a 30cm high tube extending from the bottom of the chamber. "Strong' updrafts which penetrate the whole inversion layer mimic overshooting cumulus clouds while "weak' updrafts diverging under the inversion simulate stratocumulus clouds. We use a laser sheet technique to image two-dimensional cross sections through the clouds. A specially developed mutiscale Particle Image Velicimetry (PIV) algorithm allows to retrieve 2D velocity fields. Suitable image processing allows to determine cloud-clear air interface in the images. Extracting velocities of cloudy (ui) and environmental (ua) air on both sides of the interface allows us calculate entrainment / detrainment rates: E = -ρa(ua - ui) - entrainment rate D = ρa(ua - ui) - detrainment rate. On the poster we will present fine structures of entraimnet/dertaiment process and discuss similarities and differences in both investigated types of clouds.

  12. The Goddard Earth Sciences and Technology Center (GEST Center)

    NASA Technical Reports Server (NTRS)

    2002-01-01

    The following is a technical report of the progress made under Cooperative Agreement NCC5494, the Goddard Earth Sciences and Technology Center (GEST). The period covered by this report is October 1, 2001 through December 31, 2001. GEST is a consortium of scientists and engineers, led by the University of Maryland, Baltimore County (UMBC), to conduct scientific research in Earth and information sciences and related technologies in collaboration with the NASA Goddard Space Flight Center (GSFC). GEST was established through a cooperative agreement signed May 11, 2000, following a competitive procurement process initiated by GSFC.

  13. The 1988 Goddard Conference on Space Applications of Artificial Intelligence

    NASA Technical Reports Server (NTRS)

    Rash, James (Editor); Hughes, Peter (Editor)

    1988-01-01

    This publication comprises the papers presented at the 1988 Goddard Conference on Space Applications of Artificial Intelligence held at the NASA/Goddard Space Flight Center, Greenbelt, Maryland on May 24, 1988. The purpose of this annual conference is to provide a forum in which current research and development directed at space applications of artificial intelligence can be presented and discussed. The papers in these proceedings fall into the following areas: mission operations support, planning and scheduling; fault isolation/diagnosis; image processing and machine vision; data management; modeling and simulation; and development tools/methodologies.

  14. The Altus Cumulus Electrification Study (ACES): A UAV-based Investigation of Thunderstorms

    NASA Technical Reports Server (NTRS)

    Blakeslee, Richard; Arnold, James E. (Technical Monitor)

    2001-01-01

    The Altus Cumulus Electrification Study (ACES) is a NASA-sponsored and -led science investigation that utilizes an uninhabited aerial vehicle (UAV) to investigate thunderstorms in the vicinity of the NASA Kennedy Space Center, Florida. As part of NASA's UAV-based science demonstration program, ACES will provide a scientifically useful demonstration of the utility and promise of UAV platforms for Earth science and applications observations. ACES will employ the Altus 11 aircraft, built by General Atomics-Aeronautical Systems, Inc. By taking advantage of its slow flight speed (70 to 100 knots), long endurance, and high-altitude flight (up to 55,000 feet), the Altus will be flown near, and when possible, above (but never into) thunderstorms for long periods of time, allowing investigations to be conducted over entire storm life cycles. Key science objectives simultaneously addressed by ACES are to: (1) investigate lightning-storm relationships, (2) study storm electrical budgets, and (3) provide Lightning Imaging Sensor validation. The ACES payload, already developed and flown on Altus, includes electrical, magnetic, and optical sensors to remotely characterize the lightning activity and the electrical environment within and around thunderstorms. The ACES field campaign will be conducted during July 2002 with a goal of performing 8 to 10 UAV flights. Each flight will require about 4 to 5 hours on station at altitudes from 40,000 ft to 55,000 ft. The ACES team is comprised of scientists from the NASA Marshall Space Flight Center and NASA Goddard Space Flight Centers partnered with General Atomics and IDEA, LLC.

  15. The importance of having zinc during in vitro maturation of cattle cumulus-oocyte complex: role of cumulus cells.

    PubMed

    Anchordoquy, J M; Anchordoquy, J P; Sirini, M A; Picco, S J; Peral-García, P; Furnus, C C

    2014-10-01

    The aim of this study was to investigate the influence of zinc (Zn) on the health of cumulus-oocyte complex (COC) during in vitro maturation (IVM). Experiments were designed to evaluate the effect of Zn added to IVM medium on: DNA integrity, apoptosis, cumulus expansion and superoxide dismutase (SOD) activity of cumulus cells (CC). Also, role of CC on Zn transport during IVM was evaluated on oocyte developmental capacity. DNA damage and early apoptosis were higher in CC matured with 0 μg/ml Zn compared with 0.7, 1.1 and 1.5 μg/ml Zn (p < 0.05). Cumulus expansion did not show differences in COC matured with or without Zn supplementation (p > 0.05). Superoxide dismutase activity was higher in COC matured with 1.5 μg/ml Zn than with 0 μg/ml Zn (p < 0.05). Cleavage and blastocyst rates were recorded after IVM in three maturation systems: intact COCs, denuded oocytes with cumulus cells monolayer (DO + CC) and denuded oocytes (DO). Cleavage rates were similar when COC, DO + CC or DO were matured with 1.5 μg/ml Zn compared with control group (p > 0.05). Blastocyst rates were significantly higher in COC than in DO + CC and DO with the addition of 1.5 μg/ml Zn during IVM (p < 0.01). Blastocyst quality was enhanced in COC and DO + CC compared with DO when Zn was added to IVM medium (p < 0.001). The results of this study indicate that Zn supplementation to IVM medium (i) decreased DNA damage and apoptosis in CC; (ii) increased SOD activity in CC; (iii) did not modify cumulus expansion and cleavage rates after in vitro fertilization; (iv) improved subsequent embryo development up to blastocyst stage; and (v) enhanced blastocyst quality when CC were present either in intact COC or in coculture during IVM. PMID:25131826

  16. AnisWave 2D

    2004-08-01

    AnisWave2D is a 2D finite-difference code for a simulating seismic wave propagation in fully anisotropic materials. The code is implemented to run in parallel over multiple processors and is fully portable. A mesh refinement algorithm has been utilized to allow the grid-spacing to be tailored to the velocity model, avoiding the over-sampling of high-velocity materials that usually occurs in fixed-grid schemes.

  17. Performance of the Goddard Multiscale Modeling Framework with Goddard Ice Microphysical Schemes

    NASA Technical Reports Server (NTRS)

    Chern, Jiun-Dar; Tao, Wei-Kuo; Lang, Stephen E.; Matsui, Toshihisa; Li, J.-L.; Mohr, Karen I.; Skofronick-Jackson, Gail M.; Peters-Lidard, Christa D.

    2016-01-01

    The multiscale modeling framework (MMF), which replaces traditional cloud parameterizations with cloud-resolving models (CRMs) within a host atmospheric general circulation model (GCM), has become a new approach for climate modeling. The embedded CRMs make it possible to apply CRM-based cloud microphysics directly within a GCM. However, most such schemes have never been tested in a global environment for long-term climate simulation. The benefits of using an MMF to evaluate rigorously and improve microphysics schemes are here demonstrated. Four one-moment microphysical schemes are implemented into the Goddard MMF and their results validated against three CloudSat/CALIPSO cloud ice products and other satellite data. The new four-class (cloud ice, snow, graupel, and frozen drops/hail) ice scheme produces a better overall spatial distribution of cloud ice amount, total cloud fractions, net radiation, and total cloud radiative forcing than earlier three-class ice schemes, with biases within the observational uncertainties. Sensitivity experiments are conducted to examine the impact of recently upgraded microphysical processes on global hydrometeor distributions. Five processes dominate the global distributions of cloud ice and snow amount in long-term simulations: (1) allowing for ice supersaturation in the saturation adjustment, (2) three additional correction terms in the depositional growth of cloud ice to snow, (3) accounting for cloud ice fall speeds, (4) limiting cloud ice particle size, and (5) new size-mapping schemes for snow and graupel. Despite the cloud microphysics improvements, systematic errors associated with subgrid processes, cyclic lateral boundaries in the embedded CRMs, and momentum transport remain and will require future improvement.

  18. Performance of the Goddard multiscale modeling framework with Goddard ice microphysical schemes

    NASA Astrophysics Data System (ADS)

    Chern, Jiun-Dar; Tao, Wei-Kuo; Lang, Stephen E.; Matsui, Toshihisa; Li, J.-L. F.; Mohr, Karen I.; Skofronick-Jackson, Gail M.; Peters-Lidard, Christa D.

    2016-03-01

    The multiscale modeling framework (MMF), which replaces traditional cloud parameterizations with cloud-resolving models (CRMs) within a host atmospheric general circulation model (GCM), has become a new approach for climate modeling. The embedded CRMs make it possible to apply CRM-based cloud microphysics directly within a GCM. However, most such schemes have never been tested in a global environment for long-term climate simulation. The benefits of using an MMF to evaluate rigorously and improve microphysics schemes are here demonstrated. Four one-moment microphysical schemes are implemented into the Goddard MMF and their results validated against three CloudSat/CALIPSO cloud ice products and other satellite data. The new four-class (cloud ice, snow, graupel, and frozen drops/hail) ice scheme produces a better overall spatial distribution of cloud ice amount, total cloud fractions, net radiation, and total cloud radiative forcing than earlier three-class ice schemes, with biases within the observational uncertainties. Sensitivity experiments are conducted to examine the impact of recently upgraded microphysical processes on global hydrometeor distributions. Five processes dominate the global distributions of cloud ice and snow amount in long-term simulations: (1) allowing for ice supersaturation in the saturation adjustment, (2) three additional correction terms in the depositional growth of cloud ice to snow, (3) accounting for cloud ice fall speeds, (4) limiting cloud ice particle size, and (5) new size-mapping schemes for snow and graupel. Despite the cloud microphysics improvements, systematic errors associated with subgrid processes, cyclic lateral boundaries in the embedded CRMs, and momentum transport remain and will require future improvement.

  19. Performance of the Goddard Multiscale Modeling Framework with Goddard Ice Microphysical Schemes

    NASA Astrophysics Data System (ADS)

    Chern, J. D.; Tao, W. K.; Lang, S. E.; Matsui, T.; Li, J. L. F.; Mohr, K. I.

    2015-12-01

    The multiscale modeling framework (MMF), which replaces traditional cloud parameterizations with cloud-resolving models (CRMs) within a host atmospheric general circulation model (GCM), has become a new approach for climate modeling. The embedded CRMs make it possible to apply CRM-based cloud microphysics directly within a GCM. However, most such schemes have never been tested in a global environment for long-term climate simulation. The benefits of using an MMF to evaluate rigorously and improve microphysics schemes are here demonstrated. Four one-moment microphysical schemes are implemented into the Goddard MMF and their results validated against three CloudSat/CALIPSO cloud ice products, CloudSat/CALIPSO cloud fractions, and other satellite data. The new four-class (cloud ice, snow, graupel, and frozen drops/hail) ice scheme produces a better overall spatial distribution of cloud ice amount and total cloud radiative forcing than earlier three-class ice schemes, with biases within the observational uncertainties. Sensitivity experiments are conducted to examine the impact of recently upgraded microphysical processes on global hydrometeor distributions. Five processes dominate the global distributions of cloud ice and snow amount in long-term simulations: (1) allowing for ice supersaturation in the saturation adjustment, (2) three additional correction terms in the depositional growth of cloud ice to snow, (3) accounting for cloud ice fall speeds, (4) limiting cloud ice particle size, and (5) new size-mapping schemes for snow/graupel as functions of temperature and mixing ratio. Despite the cloud microphysics improvements, systematic errors associated with sub-grid processes and cyclic lateral boundaries in the embedded CRMs remain and will require future improvement.

  20. Continuous growth of cloud droplets in cumulus cloud

    NASA Astrophysics Data System (ADS)

    Gotoh, Toshiyuki; Suehiro, Tamotsu; Saito, Izumi

    2016-04-01

    A new method to seamlessly simulate the continuous growth of droplets advected by turbulent flow inside a cumulus cloud was developed from first principle. A cubic box ascending with a mean updraft inside a cumulus cloud was introduced and the updraft velocity was self-consistently determined in such a way that the mean turbulent velocity within the box vanished. All the degrees of freedom of the cloud droplets and turbulence fields were numerically integrated. The box ascended quickly inside the cumulus cloud due to the updraft and the mean radius of the droplets grew from 10 to 24 μm for about 10 min. The turbulent flow tended to slow down the time evolutions of the updraft velocity, the box altitude and the mean cloud droplet radius. The size distribution of the cloud droplets in the updraft case was narrower than in the absence of the updraft. It was also found that the wavenumeber spectra of the variances of the temperature and water vapor mixing ratio were nearly constant in the low wavenumber range. The future development of the new method was argued.

  1. Technology transfer within the NASA Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Plotkin, Henry H.

    1992-01-01

    Viewgraphs on technology transfer within the NASA Goddard Space Flight Center presented to Civil Space Technology Development workshop on technology transfer and effectiveness are provided. Topics covered include: obstacles to technology transfer; technology transfer improvement program at GSFC: communication between technology developers and users; and user feedback to technologists.

  2. Research and Technology Report. Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Soffen, Gerald (Editor); Truszkowski, Walter (Editor); Ottenstein, Howard (Editor); Frost, Kenneth (Editor); Maran, Stephen (Editor); Walter, Lou (Editor); Brown, Mitch (Editor)

    1996-01-01

    This issue of Goddard Space Flight Center's annual report highlights the importance of mission operations and data systems covering mission planning and operations; TDRSS, positioning systems, and orbit determination; ground system and networks, hardware and software; data processing and analysis; and World Wide Web use. The report also includes flight projects, space sciences, Earth system science, and engineering and materials.

  3. NASA Goddard Space Flight Center Supply Chain Management Program

    NASA Technical Reports Server (NTRS)

    Kelly, Michael P.

    2011-01-01

    This slide presentation reviews the working of the Supplier Assessment Program at NASA Goddard Space Flight Center. The program supports many GSFC projects to ensure suppliers are aware of and are following the contractual requirements, to provide an independent assessment of the suppliers' processes, and provide suppliers' safety and mission assurance organizations information to make the changes within their organization.

  4. Carrier account utilization at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Mathis, W. E.; Langmead, J. T.

    1972-01-01

    The system in use at Goddard Space Flight Center for the utilization of the Common Use Service Carrier Account and the R&D Inventory Carrier Account technique for budgeting, accounting, financial control, and management reporting, both for the individual functional area and on a Center-wide basis, is documented.

  5. Geographic information systems at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Goldberg, M.

    1982-01-01

    The basic functions of a Geographic Information System (GIS) and the different ways that a GIS may be implemented are described. It surveys that GIS software packages that are currently in operation at the Goddard Space Flight Center and discusses the types of applications for which they are best suited. Future plans for in-house GIS research and development are outlined.

  6. Implementation of hydrologic models at Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    1974-01-01

    Major watershed simulation models were implemented on the computer system at NASA Goddard Space Flight Center, and their operation was verified. Historical and physiographic data were acquired for two Maryland river basins (Monocasy River above Jug Bridge and Patuxent River near Laurel, Maryland) and the models were calibrated to simulate them. GSFC personnel were instructed in model operation after the models were implemented.

  7. The 1994 Goddard Conference on Space Applications of Artificial Intelligence

    NASA Technical Reports Server (NTRS)

    Hostetter, Carl F. (Editor)

    1994-01-01

    This publication comprises the papers presented at the 1994 Goddard Conference on Space Applications of Artificial Intelligence held at the NASA/GSFC, Greenbelt, Maryland, on 10-12 May 1994. The purpose of this annual conference is to provide a forum in which current research and development directed at space applications of artificial intelligence can be presented and discussed.

  8. Selective binding of human cumulus cell-secreted glycoproteins to human spermatozoa during capacitation in vitro

    SciTech Connect

    Tesarik, J.; Kopecny, V.; Dvorak, M.

    1984-06-01

    The results of this study demonstrate that glycoproteins manufactured by human cumulus cells can be detected bound to human spermatozoa incubated in capacitational medium containing the labeled cumulus-cell secretions. Cumulus-cell-secreted glycoproteins were labeled with a mixture of /sup 3/H-methionine and /sup 3/H-tryptophan or with 3H-fucose, and the binding of the labeled compounds to spermatozoa was evaluated by autoradiography. The binding was highly selective, involving only approximately 1% of the samples of spermatozoa used. The results suggest that the binding of cumulus-cell-secreted glycoproteins to spermatozoa may represent a final and highly selective step in human sperm capacitation.

  9. An Intercomparison of 2-D Models Within a Common Framework

    NASA Technical Reports Server (NTRS)

    Weisenstein, Debra K.; Ko, Malcolm K. W.; Scott, Courtney J.; Jackman, Charles H.; Fleming, Eric L.; Considine, David B.; Kinnison, Douglas E.; Connell, Peter S.; Rotman, Douglas A.; Bhartia, P. K. (Technical Monitor)

    2002-01-01

    A model intercomparison among the Atmospheric and Environmental Research (AER) 2-D model, the Goddard Space Flight Center (GSFC) 2-D model, and the Lawrence Livermore National Laboratory 2-D model allows us to separate differences due to model transport from those due to the model's chemical formulation. This is accomplished by constructing two hybrid models incorporating the transport parameters of the GSFC and LLNL models within the AER model framework. By comparing the results from the native models (AER and e.g. GSFC) with those from the hybrid model (e.g. AER chemistry with GSFC transport), differences due to chemistry and transport can be identified. For the analysis, we examined an inert tracer whose emission pattern is based on emission from a High Speed Civil Transport (HSCT) fleet; distributions of trace species in the 2015 atmosphere; and the response of stratospheric ozone to an HSCT fleet. Differences in NO(y) in the upper stratosphere are found between models with identical transport, implying different model representations of atmospheric chemical processes. The response of O3 concentration to HSCT aircraft emissions differs in the models from both transport-dominated differences in the HSCT-induced perturbations of H2O and NO(y) as well as from differences in the model represent at ions of O3 chemical processes. The model formulations of cold polar processes are found to be the most significant factor in creating large differences in the calculated ozone perturbations

  10. Research and technology, 1990: Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    1990-01-01

    Goddard celebrates 1990 as a banner year in space based astronomy. From above the Earth's obscuring atmosphere, four major orbiting observatories examined the heavens at wavelengths that spanned the electromagnetic spectrum. In the infrared and microwave, the Cosmic Background Explorer (COBE), measured the spectrum and angular distribution of the cosmic background radiation to extraordinary precision. In the optical and UV, the Hubble Space Telescope has returned spectacular high resolution images and spectra of a wealth of astronomical objects. The Goddard High Resolution Spectrograph has resolved dozens of UV spectral lines which are as yet unidentified because they have never before been seen in any astronomical spectrum. In x rays, the Roentgen Satellite has begun returning equally spectacular images of high energy objects within our own and other galaxies.

  11. Stacking up 2D materials

    NASA Astrophysics Data System (ADS)

    Mayor, Louise

    2016-05-01

    Graphene might be the most famous example, but there are other 2D materials and compounds too. Louise Mayor explains how these atomically thin sheets can be layered together to create flexible “van der Waals heterostructures”, which could lead to a range of novel applications.

  12. The Effect of Cumulus Momentum Mixing on the Development of a Symmetric Model Hurricane.

    NASA Astrophysics Data System (ADS)

    Challa, Malakondayya; Pfeffer, Richard L.

    1984-04-01

    The effect of the vertical transport of horizontal momentum by cumulus clouds on the development of a symmetric model hurricane is investigated. This is accomplished by using Sundqvist's symmetric hurricane model with parameterized cumulus friction. The scheme used to include cumulus friction in the model is essentially the same as that given by Stevens and Lindzen in 1978 and Lindzen in 1981. The results of two sets of numerical integrations are presented. In one, the initial wind and moisture distributions were derived from atmospheric observations in Atlantic intensifying cyclones as composited by McBride. In the other, the initial vortex was specified as that which corresponds to the linearly most unstable mode in Mak's 1980 linear analysis of the effect of cumulus friction on hurricane formation. Given each initial wind, temperature and moisture distribution, numerical integrations were performed with and without cumulus friction present in the model.With cumulus friction included, the growth rates of the initial disturbances and their final intensities are smaller than those obtained in the absence of cumulus friction. The Atlantic intensifying cyclone with cumulus friction reaches storm strength, whereas without cumulus friction it develops into a hurricane. In the second pair of numerical integrations with the initial vortex specified as described above, the model develops hurricanes with and without cumulus frictions, but the rate of intensification and final strength of the vortex are significantly smaller when cumulus friction is included. The damping effect of cumulus friction is attributed to the fact that the angular momentum transported from the lower into the upper troposphere by cumulus mixing is not fully replenished in the lower troposphere by the cumulus induced secondary (radial) circulation. This contrasts with the effect of the inward eddy flux of momentum, reported on previously, which was found to enhance the intensification of hurricanes

  13. The Goddard High Resolution Spectrograph: Instrument, goals, and science results

    NASA Astrophysics Data System (ADS)

    Brandt, J. C.; Heap, S. R.; Beaver, E. A.; Boggess, A.; Carpenter, K. G.; Ebbets, D. C.; Hutchings, J. B.; Jura, M.; Leckrone, D. S.; Linsky, J. L.; Maran, S. P.; Savage, B. D.; Smith, A. M.; Trafton, L. M.; Walter, F. M.; Weymann, R. J.; Ake, T. B.; Bruhweiler, F.; Cardelli, J. A.; Lindler, D. J.; Malumuth, E.; Randall, C. E.; Robinson, R.; Shore, S. N.; Wahlgren, G.

    1994-08-01

    The Goddard High Resolution Spectrograph (GHRS), currently in Earth orbit on the Hubble Space Telescope (HST), operates in the wavelength range 1150-3200 A with spectral resolutions (lambda/delta lambda) of approximately 2 x 103, 2 x 104, and 1 x 103. The instrument and its development from inception, its current status, the approach to operations, representative results in the major areas of the scientific goals, and prospects for the future are described.

  14. Satellite laser ranging work at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Mcgunigal, T. E.; Carrion, W. J.; Caudill, L. O.; Grant, C. R.; Johnson, T. S.; Premo, D. A.; Spadin, P. L.; Winston, G. C.

    1975-01-01

    The paper describes the satellite laser ranging system at the Goddard Space Flight Center, its range and accuracy capabilities, and planned improvements for future systems. Major subsystems are described, including the laser, optical/mechanical, receiver, computer/software, timing, and laser data preprocessing subsystems. Operational considerations are examined, with attention given the mobile station layout, manpower requirements, and transportability. System performance is considered, with emphasis on system accuracy (calibration, stability, clock synchronization, atmospheric propagation correction) and range capability.

  15. The Goddard High Resolution Spectrograph: Instrument, goals, and science results

    NASA Technical Reports Server (NTRS)

    Brandt, J. C.; Heap, S. R.; Beaver, E. A.; Boggess, A.; Carpenter, K. G.; Ebbets, D. C.; Hutchings, J. B.; Jura, M.; Leckrone, D. S.; Linsky, J. L.

    1994-01-01

    The Goddard High Resolution Spectrograph (GHRS), currently in Earth orbit on the Hubble Space Telescope (HST), operates in the wavelength range 1150-3200 A with spectral resolutions (lambda/delta lambda) of approximately 2 x 10(exp 3), 2 x 10(exp 4), and 1 x 10(exp 3). The instrument and its development from inception, its current status, the approach to operations, representative results in the major areas of the scientific goals, and prospects for the future are described.

  16. Reliability Practice at NASA Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Pruessner, Paula S.; Li, Ming

    2008-01-01

    This paper describes in brief the Reliability and Maintainability (R&M) Programs performed directly by the reliability branch at Goddard Space Flight Center (GSFC). The mission assurance requirements flow down is explained. GSFC practices for PRA, reliability prediction/fault tree analysis/reliability block diagram, FMEA, part stress and derating analysis, worst case analysis, trend analysis, limit life items are presented. Lessons learned are summarized and recommendations on improvement are identified.

  17. The 1977 Goddard Space Flight Center Battery Workshop

    NASA Technical Reports Server (NTRS)

    1977-01-01

    The papers presented were derived from transcripts taken at the Tenth Annual Battery Workshop held at the Goddard Space Flight Center, November 15-17, 1977. The Workshop was attended by manufacturers, users, and government representatives interested in the latest results of testing, analysis, and development of the sealed nickel cadmium cell system. The purpose of the Workshop was to share flight and test experience, stimulate discussion on problem areas, and to review the latest technology improvements.

  18. The 1990 Goddard Conference on Space Applications of Artificial Intelligence

    NASA Technical Reports Server (NTRS)

    Rash, James L. (Editor)

    1990-01-01

    The papers presented at the 1990 Goddard Conference on Space Applications of Artificial Intelligence are given. The purpose of this annual conference is to provide a forum in which current research and development directed at space applications of artificial intelligence can be presented and discussed. The proceedings fall into the following areas: Planning and Scheduling, Fault Monitoring/Diagnosis, Image Processing and Machine Vision, Robotics/Intelligent Control, Development Methodologies, Information Management, and Knowledge Acquisition.

  19. Aerospace Battery Activities at NASA/Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Rao, Gopalakrishna M.

    2006-01-01

    Goddard Space Flight Center has "pioneered" rechargeable secondary battery design, test, infusion and in-orbit battery management among NASA installations. Nickel cadmium batteries of various designs and sizes have been infused for LEO, GEO and Libration Point spacecraft. Nickel-Hydrogen batteries have currently been baselined for the majority of our missions. Li-Ion batteries from ABSL, JSB, SaFT and Lithion have been designed and tested for aerospace application.

  20. RFI Risk Reduction Activities Using New Goddard Digital Radiometry Capabilities

    NASA Technical Reports Server (NTRS)

    Bradley, Damon; Kim, Ed; Young, Peter; Miles, Lynn; Wong, Mark; Morris, Joel

    2012-01-01

    The Goddard Radio-Frequency Explorer (GREX) is the latest fast-sampling radiometer digital back-end processor that will be used for radiometry and radio-frequency interference (RFI) surveying at Goddard Space Flight Center. The system is compact and deployable, with a mass of about 40 kilograms. It is intended to be flown on aircraft. GREX is compatible with almost any aircraft, including P-3, twin otter, C-23, C-130, G3, and G5 types. At a minimum, the system can function as a clone of the Soil Moisture Active Passive (SMAP) ground-based development unit [1], or can be a completely independent system that is interfaced to any radiometer, provided that frequency shifting to GREX's intermediate frequency is performed prior to sampling. If the radiometer RF is less than 200MHz, then the band can be sampled and acquired directly by the system. A key feature of GREX is its ability to simultaneously sample two polarization channels simultaneously at up to 400MSPS, 14-bit resolution each. The sampled signals can be recorded continuously to a 23 TB solid-state RAID storage array. Data captures can be analyzed offline using the supercomputing facilities at Goddard Space Flight Center. In addition, various Field Programmable Gate Array (FPGA) - amenable radiometer signal processing and RFI detection algorithms can be implemented directly on the GREX system because it includes a high-capacity Xilinx Virtex-5 FPGA prototyping system that is user customizable.

  1. An Empirical Cumulus Parameterization Scheme for a Global Spectral Model

    NASA Technical Reports Server (NTRS)

    Rajendran, K.; Krishnamurti, T. N.; Misra, V.; Tao, W.-K.

    2004-01-01

    Realistic vertical heating and drying profiles in a cumulus scheme is important for obtaining accurate weather forecasts. A new empirical cumulus parameterization scheme based on a procedure to improve the vertical distribution of heating and moistening over the tropics is developed. The empirical cumulus parameterization scheme (ECPS) utilizes profiles of Tropical Rainfall Measuring Mission (TRMM) based heating and moistening derived from the European Centre for Medium- Range Weather Forecasts (ECMWF) analysis. A dimension reduction technique through rotated principal component analysis (RPCA) is performed on the vertical profiles of heating (Q1) and drying (Q2) over the convective regions of the tropics, to obtain the dominant modes of variability. Analysis suggests that most of the variance associated with the observed profiles can be explained by retaining the first three modes. The ECPS then applies a statistical approach in which Q1 and Q2 are expressed as a linear combination of the first three dominant principal components which distinctly explain variance in the troposphere as a function of the prevalent large-scale dynamics. The principal component (PC) score which quantifies the contribution of each PC to the corresponding loading profile is estimated through a multiple screening regression method which yields the PC score as a function of the large-scale variables. The profiles of Q1 and Q2 thus obtained are found to match well with the observed profiles. The impact of the ECPS is investigated in a series of short range (1-3 day) prediction experiments using the Florida State University global spectral model (FSUGSM, T126L14). Comparisons between short range ECPS forecasts and those with the modified Kuo scheme show a very marked improvement in the skill in ECPS forecasts. This improvement in the forecast skill with ECPS emphasizes the importance of incorporating realistic vertical distributions of heating and drying in the model cumulus scheme. This

  2. Sensitivity of land surface and Cumulus schemes for Thunderstorm prediction

    NASA Astrophysics Data System (ADS)

    Kumar, Dinesh; Mohanty, U. C.; Kumar, Krishan

    2016-06-01

    The cloud processes play an important role in all forms of precipitation. Its proper representation is one of the challenging tasks in mesoscale numerical simulation. Studies have revealed that mesoscale feature require proper initialization which may likely to improve the convective system rainfall forecasts. Understanding the precipitation process, model initial condition accuracy and resolved/sub grid-scale precipitation processes representation, are the important areas which needed to improve in order to represent the mesoscale features properly. Various attempts have been done in order to improve the model performance through grid resolution, physical parameterizations, etc. But it is the physical parameterizations which provide a convective atmosphere for the development and intensification of convective events. Further, physical parameterizations consist of cumulus convection, surface fluxes of heat, moisture, momentum, and vertical mixing in the planetary boundary layer (PBL). How PBL and Cumulus schemes capture the evolution of thunderstorm have been analysed by taking thunderstorm cases occurred over Kolkata, India in the year 2011. PBL and cumulus schemes were customized for WSM-6 microphysics because WSM series has been widely used in operational forecast. Results have shown that KF (PBL scheme) and WSM-6 (Cumulus Scheme) have reproduced the evolution of surface variable such as CAPE, temperature and rainfall very much like observation. Further, KF and WSM-6 scheme also provided the increased moisture availability in the lower atmosphere which was taken to higher level by strong vertical velocities providing a platform to initiate a thunderstorm much better. Overestimation of rain in WSM-6 occurs primarily because of occurrence of melting and freezing process within a deeper layer in WSM-6 scheme. These Schemes have reproduced the spatial pattern and peak rainfall coverage closer to TRMM observation. It is the the combination of WSM-6, and KF schemes

  3. Clouds and entrainment. [cumulus convective turbulence in clear air

    NASA Technical Reports Server (NTRS)

    Randall, D. A.

    1982-01-01

    The concept of entrainment is discussed, and the knowledge that has been acquired about entraining turbulence in clear air is surveyed. Attention is then given to observations and models of stratocumulus entrainment, which show some of the ways in which cloudiness modifies the entrainment process. Entraining cumuli are also considered, with some of the differences between cumulus entrainment and stratocumulus entrainment noted. Emphasis is placed on the dynamical aspects of entrainment; its effects on droplet spectra and other microphysical aspects are mentioned only briefly.

  4. POTENTIAL CONTRIBUTION OF SULFATE PRODUCTION IN CUMULUS CLOUD DROPLETS TO GROUND LEVEL PARTICLE SULFUR CONCENTRATIONS

    EPA Science Inventory

    Relationships have been examined between the presence or absence of cumulus clouds and 3rd quarter fine particle sulfur concentrations in St. Louis. An association between the presence of cumulus clouds with SO2 conversions in droplets and incrementally higher fine particle sulfu...

  5. Influence of hyaluronan accumulation during cumulus expansion on in vitro porcine oocyte maturation.

    PubMed

    Yokoo, Masaki; Kimura, Naoko; Abe, Hiroyuki; Sato, Eimei

    2008-11-01

    During oocyte maturation, the cumulus-oocyte complexes (COCs) expand dramatically. This phenomenon, which is known as cumulus expansion, is the result of the synthesis and accumulation of hyaluronan in the extracellular space between cumulus cells. The purpose of this study was to investigate the effect of 6-diazo-5-oxo-l-norleucine (DON), an inhibitor of hyaluronan synthesis, on cumulus expansion during in vitro porcine oocyte maturation and hyaluronan accumulation within COCs. Further, this study aimed to examine the influence of hyaluronan accumulation within COCs on the rate of oocyte maturation. Cumulus expansion was observed during in vitro maturation. However, the addition of DON to the maturation medium significantly inhibited cumulus expansion. The total inhibition of hyaluronan accumulation within COCs was observed with the use of confocal microscopy. Moreover, a positive correlation between the area of cumulus expansion and the rate of oocyte maturation was observed. These results demonstrate that the hyaluronan accumulation within the COCs during oocyte maturation affects oocyte maturation. On the basis of these results, we propose that hyaluronan accumulation within the COCs during cumulus expansion is a necessary step in the porcine oocyte maturation process. PMID:18838022

  6. MOSS2D V1

    2001-01-31

    This software reduces the data from two-dimensional kSA MOS program, k-Space Associates, Ann Arbor, MI. Initial MOS data is recorded without headers in 38 columns, with one row of data per acquisition per lase beam tracked. The final MOSS 2d data file is reduced, graphed, and saved in a tab-delimited column format with headers that can be plotted in any graphing software.

  7. O Shallow Cumulus Parameterization Schemes for General Circulation Model Planetary Boundary Layers

    NASA Astrophysics Data System (ADS)

    Li, Jui-Lin Frank

    Shallow non-precipitating cumulus clouds play an important role in atmospheric boundary layers and global energetics. It is very important that a shallow cumulus scheme should be able to represent these clouds under different kinds of weather in a GCM. The objectives of this study are to test different parameterization schemes recently used in GCMs, develop modified schemes based on them, and create a new cumulus eddy diffusion scheme. A one-dimensional PBL model representing small-scale turbulence and cumulus effects is used to perform a series of high resolution numerical integrations. Data sets for undisturbed quasi -steady tradewind conditions during BOMEX and ATEX are used for comparisons. The simulation of stronger cumulus regimes is achieved by increasing sea surface temperature and studying idealized cold air flow over a warmer sea. Dry turbulence diffusion is represented by either an explicit dry turbulent diffusion scheme (Louis, 1982) used in the ECMWF grid level model, or a nonlocal convective scheme proposed by Holtslag and Moeng (1991). The high vertical resolution (50m) PBL model is then integrated in time with several shallow cumulus parameterization schemes: a simple cumulus mass flux model, Betts-Miller adjustment (1986), simple K-theory (Tiedtke, 1984), modifications of each of them, and a new cumulus diffusion scheme, respectively. The modified cumulus mass flux scheme decreases cumulus mass flux linearly from the cloud base to mid-subcloud layer to represent cloud root effects. The modified Betts-Miller schemes are defined by considering subcloud layer adjustment and curved approximate reference profiles with a constraint of constant virtual potential temperature in the subcloud layer. A new cumulus diffusion scheme estimates the cumulus eddy diffusivities from entrained cloud available potential energy and formulates the nonlocal cumulus flux by coupling the cumulus-scale fluxes with large-scale dry thermals at the cloud base. The results show

  8. Investigations of cumulus entrainment rates through remotely-sensed observations

    NASA Astrophysics Data System (ADS)

    Wagner, T. J.; Turner, D. D.; Berg, L. K.

    2010-12-01

    The entrainment of environmental air into cumulus impacts the radiative, microphysical, and thermodynamic characteristics of the cloud, and by extension, the environment. A need for a robust method to observe entrainment rate without the use of in situ observations has lead to the development of an algorithm to retrieve entrainment rate remotely. Thermodynamic profiles are obtained from the suite of ground-based instruments located at the Southern Great Plains (SGP) site of the United States Department of Energy's Atmospheric Radiation Measurement (ARM) Climate Research Facility. These profiles are used as inputs into the Entrainment Mixing Parcel Model (EMPM), which treats entrainment as a series of discrete mixing events. Output from EMPM is used to calculate quantities that can be observed from the surface, including effective radius and liquid water path. The entrainment rate is adjusted iteratively using Gauss-Newton optimal estimation until convergence with observations is reached. This algorithm currently retrieves the entrainment rate of individual cumulus clouds and shows good agreement with aircraft-based observations.

  9. The Defensive Role of Cumulus Cells Against Reactive Oxygen Species Insult in Metaphase II Mouse Oocytes.

    PubMed

    Shaeib, Faten; Khan, Sana N; Ali, Iyad; Thakur, Mili; Saed, Mohammed G; Dai, Jing; Awonuga, Awoniyi O; Banerjee, Jashoman; Abu-Soud, Husam M

    2016-04-01

    We investigated the ability of reactive oxygen species (ROS), such as hydrogen peroxide (H2O2), hydroxyl radical ((·)OH), and hypochlorous acid (HOCl), to overcome the defensive capacity of cumulus cells and elucidate the mechanism through which ROS differentially deteriorate oocyte quality. Metaphase II mouse oocytes with (n = 1634) and without cumulus cells (n = 1633) were treated with increasing concentration of ROS, and the deterioration in oocyte quality was assessed by the changes in the microtubule morphology and chromosomal alignment. Oocyte and cumulus cell viability and cumulus cell number were assessed by indirect immunofluorescence, staining of gap junction protein, and trypan blue staining. The treated oocytes showed decreased quality as a function of increasing concentrations of ROS when compared to controls. Cumulus cells show protection against H2O2 and (·)OH insult at lower concentrations, but this protection was lost at higher concentrations (>50 μmol/L). At higher H2O2 concentrations, treatment dramatically influenced the cumulus cell number and viability with resulting reduction in the antioxidant capacity making the oocyte more susceptible to oxidative damage. However, cumulus cells offered no significant protection against HOCl at any concentration used. In all circumstances in which cumulus cells did not offer protection to the oocyte, both cumulus cell number and viability were decreased. Therefore, the deterioration in oocyte quality may be caused by one or more of the following: a decrease in the antioxidant machinery by the loss of cumulus cells, the lack of scavengers for specific ROS, and/or the ability of the ROS to overcome these defenses. PMID:26468254

  10. Nanoimprint lithography: 2D or not 2D? A review

    NASA Astrophysics Data System (ADS)

    Schift, Helmut

    2015-11-01

    Nanoimprint lithography (NIL) is more than a planar high-end technology for the patterning of wafer-like substrates. It is essentially a 3D process, because it replicates various stamp topographies by 3D displacement of material and takes advantage of the bending of stamps while the mold cavities are filled. But at the same time, it keeps all assets of a 2D technique being able to pattern thin masking layers like in photon- and electron-based traditional lithography. This review reports about 20 years of development of replication techniques at Paul Scherrer Institut, with a focus on 3D aspects of molding, which enable NIL to stay 2D, but at the same time enable 3D applications which are "more than Moore." As an example, the manufacturing of a demonstrator for backlighting applications based on thermally activated selective topography equilibration will be presented. This technique allows generating almost arbitrary sloped, convex and concave profiles in the same polymer film with dimensions in micro- and nanometer scale.

  11. Satellite communications at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Clark, J. F.; Redisch, W. N.

    1976-01-01

    Starting with the 1960 Delta launch of the first Echo satellite, NASA's Goddard Space Flight Center (GSFC) became one of the pioneers in satellite communications. Attention is given to the project Syncom, the Applications Technology Satellite (ATS) program, the ATS-6 project, and current GSFC efforts. After the decision announced in January of 1973 that NASA would phase out of communications satellite programs, the communications effort at GSFC concentrates on the operation of ATS spacecraft in orbit, experiments in the 12- to 14 GHz frequency band, and advanced communications research.

  12. The Goddard program of gamma-ray transient astronomy

    NASA Technical Reports Server (NTRS)

    Cline, T. L.; Desai, U. D.; Teegarden, B. J.

    1981-01-01

    The Goddard program of gamma-ray burst studies is briefly reviewed. The past results, present status and future expectations are outlined regarding our endeavors using experiments on balloons. IMP-6 and IMP-7, OGO-3, ISEE-1 and ISEE-3, Helios-2, Solar Maximum Mission, the Einstein Observatory, Solar Polar and the Gamma Ray Observatory, and with the interplanetary gamma-ray burst networks, to which some of these spacecraft sensors contribute. Additional emphasis is given to the recent discovery of a new type of gamma-ray transient, detected on 5 March, 1979.

  13. Robert Goddard Young, DC, ND: Searching for a better way

    PubMed Central

    Brown, Douglas M.

    2009-01-01

    This biographical study tracks the life of Robert Goddard Young; a member of the Canadian Memorial Chiropractic College’s (CMCC) Class of 1950. The paper begins with an overview of Robert Young’s origins, his childhood and early training, moves to his tour of duty in World War II, followed by his education at CMCC, before converging on the core of this matter; Robert Young’s professional career, which spanned over half a century. Now in his twilight years, the paper ends with a discussion on the substance of Dr. Young’s largely-forgotten contributions. PMID:19714235

  14. Precision orbit determination at the NASA Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Putney, B.; Kolenkiewicz, R.; Smith, D.; Dunn, P.; Torrence, M. H.

    1990-01-01

    This paper describes the GEODYN computer program developed by the Geodynamics Branch at the NASA Goddard Space Flight Center and outlines the procedure for accurate satellite orbit and tracking-data analyses. The capabilities of the program allow the development of gravity fields as large as 90 by 90, and a complete modeling of tidal parameters. It is also feasible to numerically integrate a continuous orbit of a satellite such as Lageos for up to 12 years. The evolution of the orbit can be studied, and, by comparison with locally determined orbits, force model improvements can be made. The GEODYN flow diagrams are presented.

  15. The 1988 Goddard Space Flight Center Battery Workshop

    NASA Technical Reports Server (NTRS)

    Yi, Thomas Y. (Editor)

    1993-01-01

    This document contains the proceedings of the 21st annual Battery Workshop held at Goddard Space Flight Center, Greenbelt, Maryland on November 1-3, 1988. The Workshop attendees included manufacturers, users, and government representatives interested in the latest developments in battery technology as they relate to high reliability operations and aerospace use. The subjects covered included battery testing methodologies and criteria, life testing of nickel-cadmium cells, testing and operation of nickel-hydrogen batteries in low earth orbit, and nickel-hydrogen technology issues and concerns.

  16. Ground System Harmonization Efforts at NASA's Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Smith, Dan

    2011-01-01

    This slide presentation reviews the efforts made at Goddard Space Flight Center in harmonizing the ground systems to assist in collaboration in space ventures. The key elements of this effort are: (1) Moving to a Common Framework (2) Use of Consultative Committee for Space Data Systems (CCSDS) Standards (3) Collaboration Across NASA Centers (4) Collaboration Across Industry and other Space Organizations. These efforts are working to bring into harmony the GSFC systems with CCSDS standards to allow for common software, use of Commercial Off the Shelf Software and low risk development and operations and also to work toward harmonization with other NASA centers

  17. The 1987 Goddard Space Flight Center Battery Workshop

    NASA Technical Reports Server (NTRS)

    Morrow, George (Editor); Yi, Thomas Y. (Editor)

    1993-01-01

    This document contains the proceedings of the 20th annual Battery Workshop held at Goddard Space Flight Center, Greenbelt, Maryland on November 4-5, 1987. The workshop attendees included manufacturers, users, and government representatives interested in the latest developments in battery technology as they relate to high reliability operations and aerospace use. The subjects covered included lithium cell technology and safety improvements, nickel-cadmium electrode technology along with associated modifications, flight experience and life testing of nickel-cadmium cells, and nickel-hydrogen applications and technology.

  18. The 1991 research and technology report, Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Soffen, Gerald (Editor); Ottenstein, Howard (Editor); Montgomery, Harry (Editor); Truszkowski, Walter (Editor); Frost, Kenneth (Editor); Sullivan, Walter (Editor); Boyle, Charles (Editor)

    1991-01-01

    The 1991 Research and Technology Report for Goddard Space Flight Center is presented. Research covered areas such as (1) earth sciences including upper atmosphere, lower atmosphere, oceans, hydrology, and global studies; (2) space sciences including solar studies, planetary studies, Astro-1, gamma ray investigations, and astrophysics; (3) flight projects; (4) engineering including robotics, mechanical engineering, electronics, imaging and optics, thermal and cryogenic studies, and balloons; and (5) ground systems, networks, and communications including data and networks, TDRSS, mission planning and scheduling, and software development and test.

  19. R and T report: Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Soffen, Gerald A. (Editor)

    1993-01-01

    The 1993 Research and Technology Report for Goddard Space Flight Center is presented. Research covered areas such as (1) flight projects; (2) space sciences including cosmology, high energy, stars and galaxies, and the solar system; (3) earth sciences including process modeling, hydrology/cryology, atmospheres, biosphere, and solid earth; (4) networks, planning, and information systems including support for mission operations, data distribution, advanced software and systems engineering, and planning/scheduling; and (5) engineering and materials including spacecraft systems, material and testing, optics and photonics and robotics.

  20. Vegetation-atmosphere interactions and boundary layer cumulus clouds

    NASA Astrophysics Data System (ADS)

    Freedman, Jeffrey Michael

    2000-07-01

    A study of vegetation-atmosphere interactions and boundary layer cumulus clouds (``BLcu'') in terms of seasonal trends (i.e., heat and moisture tendencies) and short-term events (specifically the modification of in situ air masses) is presented. In the northeastern U.S., in response to increasing insolation and sensible heat flux, both the mixed layer height (zi) and lifting condensation level (LCL) peak (~1300 and 1700 m) just before the start of the growing season. With the commencement of transpiration, the Bowen ratio (β) falls abruptly (from greater than 3 to less than 1) as additional moisture is transpired into the boundary layer, and zi and the LCL decrease. By late spring, boundary layer cumulus cloud frequency increases sharply, as the mixed layer approaches a new equilibrium. At Harvard Forest during 1995, afternoon net carbon uptake (Fco2 ) was 52% greater on days with boundary layer cumulus clouds than clear days. For 1996-1998, afternoon Fco2 was also enhanced, especially during dry periods. The same enhancement, albeit reduced, was observed at a northern jack pine site during the BOREAS project, despite very different phenological, hydrological, and climatological regimes. Sixteen frontal sequences affecting the northeastern U.S. were analyzed in terms of local and regional contributions to the temperature and moisture tendency equations. A composite of sequences featuring the daily appearance of BLcu indicates a diminished role for entrainment and other external forcings due to the daily occurrence of a rapid growth phase in ML diurnal evolution subsequent to day 1. From the sequence minimum (day 2) in temperature and moisture, surface flux convergence accounts for about 50% of the overall net moistening and heating of the mixed layer. Model sensitivity tests show that changes in subsidence and γ θν affect ML processes most on day 1; dining subsequent days, the rapid growth phase dominates the ML growth equation, and reduces the impact of these

  1. Effects of selected endocrine disruptors on meiotic maturation, cumulus expansion, synthesis of hyaluronan and progesterone by porcine oocyte-cumulus complexes.

    PubMed

    Mlynarcíková, Alzbeta; Nagyová, Eva; Ficková, Mária; Scsuková, Sona

    2009-04-01

    In most mammals, before ovulation, cumulus cells synthesize a large amount of hyaluronan (HA) that is organized into an extracellular matrix (ECM), which provides an essential microenvironment for in vivo oocyte fertilization. This process is called cumulus expansion. The present study assessed effects of selected endocrine disruptors (bisphenol A, BPA; 4-chloro-3-methyl phenol, CMP; di(2-ethylhexyl) phthalate, DEHP; and benzyl butyl phthalate, BBP) in a range of 100pM-100microM, on follicle-stimulating hormone (FSH)-induced meiotic maturation and cumulus expansion of porcine oocyte-cumulus complexes (OCC) cultured in vitro. Moreover, FSH-stimulated production of hyaluronic acid (HA) and progesterone by cumulus cells was measured. Both phenols, BPA and CMP (100microM), significantly affected meiotic maturation of oocytes. The number of oocytes that underwent germinal vesicle breakdown (GVBD) (78.7% and 72.4%, respectively) as well as the rate of oocytes that reached metaphase II stage (MII) (50% and 53.6%, respectively) after 44h culture were decreased compared to control (89.6% for GVBD and 81.5% for MII). FSH-stimulated expansion of cumulus was altered by the highest concentration of BPA and CMP (70% and 64%, respectively vs. 80.3% in control). Although BPA did not alter FSH-stimulated HA synthesis by cumulus cells, its incorporation within the complex was reduced to a half of control value. Progesterone production by OCC was significantly changed in the presence of BPA or DEHP. Finally, our results provide valuable information that oocyte meiotic progression was adversely affected during in vitro culture with endocrine disruptors. PMID:19162163

  2. MicroRNA-378 regulates oocyte maturation via the suppression of aromatase in porcine cumulus cells.

    PubMed

    Pan, Bo; Toms, Derek; Shen, Wei; Li, Julang

    2015-03-15

    We sought to investigate whether miR-378 plays a role in cumulus cells and whether the manipulation of miRNA levels in cumulus cells influences oocyte maturation in vitro. Cumulus-oocyte complexes (COCs) from ovarian follicles had significantly lower levels of precursor and mature miR-378 in cumulus cells surrounding metaphase II (MII) oocytes than cumulus cells surrounding germinal vesicle (GV) oocytes, suggesting a possible role of miR-378 during COC maturation. Overexpression of miR-378 in cumulus cells impaired expansion and decreased expression of genes associated with expansion (HAS2, PTGS2) and oocyte maturation (CX43, ADAMTS1, PGR). Cumulus cell expression of miR-378 also suppressed oocyte progression from the GV to MII stage (from 54 ± 2.7 to 31 ± 5.1%), accompanied by a decrease of growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15), zona pellucida 3 (ZP3), and CX37 in the oocytes. Subsequent in vitro fertilization resulted in fewer oocytes from COCs overexpressing miR-378 reaching the blastocyst stage (7.3 ± 0.7 vs. 16.6 ± 0.5%). miR-378 knockdown led to increased cumulus expansion and oocyte progression to MII, confirming a specific effect of miR-378 in suppressing COC maturation. Aromatase (CYP19A1) expression in cumulus cells was also inhibited by miR-378, leading to a significant decrease in estradiol production. The addition of estradiol to IVM culture medium reversed the effect of miR-378 on cumulus expansion and oocyte meiotic progression, suggesting that decreased estradiol production via suppression of aromatase may be one of the mechanisms by which miR-378 regulates the maturation of COCs. Our data suggest that miR-378 alters gene expression and function in cumulus cells and influences oocyte maturation, possibly via oocyte-cumulus interaction and paracrine regulation. PMID:25628423

  3. Interactions between oocytes and cumulus cells during in vitro maturation of porcine cumulus-oocyte complexes in a chemically defined medium: effect of denuded oocytes on cumulus expansion and oocyte maturation.

    PubMed

    Appeltant, R; Somfai, T; Nakai, M; Bodó, S; Maes, D; Kikuchi, K; Van Soom, A

    2015-03-01

    The aim of the present study was to clarify interactions between oocytes and cumulus cells (CCs) on the level of cumulus expansion and oocyte maturation during IVM of cumulus-oocyte complexes (COCs) in a chemically defined medium using a system that allows individual tracking of oocytes. Especially, the influence of oocyte-secreted factors was investigated by the aid of addition of denuded oocytes (DOs) as a possible approach to improve the IVM system. The basic maturation medium was porcine oocyte medium with addition of gonadotropins only during the first 20 hours of IVM. During IVM, COCs were kept fixed to the bottom of culture dish by adhesive Cell-Tak coating, which enabled individual tracking of COCs during IVM. Size changes in COCs during IVM were measured by digital image analysis. Cumulus expansion in a porcine oocyte medium of intact COCs increased in a typical manner until 20 hours and decreased in size subsequently until 48 hours of IVM (P < 0.05). Removal of oocytes from COCs by oocytectomy allowed the expansion of CCs to some extent, although their expansion ability was lower than that of COCs (P < 0.05). Addition of DOs (COCs to DOs ratio of 9:16) did not improve cumulus expansion and oocyte maturation rates of intact COCs (P > 0.05) but did enhance cumulus expansion of oocytectomized complexes (P < 0.05). Furthermore, removal of CCs before IVM increased oocyte maturation rates compared with COCs (52.3% and 32.9%, respectively) (P < 0.05) and a similar effect was observed in COCs when the gap junction inhibitor carbenoxolone was added to the IVM medium: carbenoxolone repressed the expansion of COCs at 20 hours of IVM. In conclusion, the porcine oocyte enhances cumulus expansion both by gap junctional communications and presumably by oocyte-secreted factor production. Nevertheless, the presence of oocytes is not a prerequisite for this process. In return, CCs maintain meiotic arrest in cumulus-enclosed oocytes during the initial culture

  4. An evaluation of the Goddard Space Flight Center Library

    NASA Technical Reports Server (NTRS)

    Herner, S.; Lancaster, F. W.; Wright, N.; Ockerman, L.; Shearer, B.; Greenspan, S.; Mccartney, J.; Vellucci, M.

    1979-01-01

    The character and degree of coincidence between the current and future missions, programs, and projects of the Goddard Space Flight Center and the current and future collection, services, and facilities of its library were determined from structured interviews and discussions with various classes of facility personnel. In addition to the tabulation and interpretation of the data from the structured interview survey, five types of statistical analyses were performed to corroborate (or contradict) the survey results and to produce useful information not readily attainable through survey material. Conclusions reached regarding compatability between needs and holdings, services and buildings, library hours of operation, methods of early detection and anticipation of changing holdings requirements, and the impact of near future programs are presented along with a list of statistics needing collection, organization, and interpretation on a continuing or longitudinal basis.

  5. Satellite laser ranging work at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Mcgunigal, T. E.; Carrion, W. J.; Caudill, L. O.; Grant, C. R.; Johnson, T. S.; Premo, D. A.; Spadin, P. L.; Winston, G. C.

    1975-01-01

    The pulsed-laser satellite ranging systems presently being operated by the Goddard Space Flight Center are described along with their range and accuracy capabilities. The major subsystems are outlined, operation of the fixed system and the two mobile systems is discussed, and the performance of all three systems is evaluated. It is noted that these systems have an accuracy of better than 10 cm on a carefully surveyed range as well as in regular satellite ranging operations and are capable of ranging to all currently launched retroreflector-equipped satellites with the exception of Timation III. Future improvements discussed include a third mobile system which will be able to range distant satellites, such as Timation III, with an accuracy of better than 5 cm and the use of a frequency-doubled Nd:YAG laser in place of the ruby lasers now being employed.

  6. CCSDS telemetry systems experience at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Carper, Richard D.; Stallings, William H., III

    1990-01-01

    NASA Goddard Space Flight Center (GSFC) designs, builds, manages, and operates science and applications spacecraft in near-earth orbit, and provides data capture, data processing, and flight control services for these spacecraft. In addition, GSFC has the responsibility of providing space-ground and ground-ground communications for near-earth orbiting spacecraft, including those of the manned spaceflight programs. The goal of reducing both the developmental and operating costs of the end-to-end information system has led the GSFC to support and participate in the standardization activities of the Consultative Committee for Space Data Systems (CCSDS), including those for packet telemetry. The environment in which such systems function is described, and the GSFC experience with CCSDS packet telemetry in the context of the Gamma-Ray Observatory project is discussed.

  7. Observing system simulation experiments at NASA. Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Atlas, R.; Kalnay, E.; Baker, W. E.; Susskind, J.; Reuter, D.; Halem, M.

    1985-01-01

    A series of realistic simulation studies is being conducted as a cooperative effort between the European Centre for Medium Range Weather Forecasts (ECMWF), the National Meteorological Center (NMC), and the Goddard Laboratory for Atmospheres (GLA), to provide a quantitative assessment of the potential impact of future observing systems on large scale numerical weather prediction. A special objective is to avoid the unrealistic character of earlier simulation studies. Following a brief review of previous simulation studies and real data impact tests, the methodology for the current simulation system will be described. Results from an assessment of the realism of the simulation system and of the potential impact of advanced observing systems on numerical weather prediction and preliminary results utilizing this system will be presented at the conference.

  8. The NASA Goddard Space Flight Center Virtual Science Fair

    NASA Technical Reports Server (NTRS)

    Bolognese, Jeff; Walden, Harvey; Obenschain, Arthur F. (Technical Monitor)

    2001-01-01

    This report describes the development of the NASA Goddard Space Flight Center Virtual Science Fair, including its history and outgrowth from the traditional regional science fairs supported by NASA. The results of the 1999 Virtual Science Fair pilot program, the mechanics of running the 2000 Virtual Science Fair and its results, and comments and suggestions for future Virtual Science Fairs are provided. The appendices to the report contain supporting documentation, including the original proposal for this project, the judging criteria, the user's guide and the judge's guide to the Virtual Science Fair Web site, the Fair publicity brochure and the Fair award designs, judges' and students' responses to survey questions about the Virtual Science Fair, and lists of student entries to both the 1999 and 2000 Fairs.

  9. Goddard Space Flight Center solar array missions, requirements and directions

    NASA Technical Reports Server (NTRS)

    Gaddy, Edward; Day, John

    1994-01-01

    The Goddard Space Flight Center (GSFC) develops and operates a wide variety of spacecraft for conducting NASA's communications, space science, and earth science missions. Some are 'in house' spacecraft for which the GSFC builds the spacecraft and performs all solar array design, analysis, integration, and test. Others are 'out of house' spacecraft for which an aerospace contractor builds the spacecraft and develops the solar array under direction from GSFC. The experience of developing flight solar arrays for numerous GSFC 'in house' and 'out of house' spacecraft has resulted in an understanding of solar array requirements for many different applications. This presentation will review those solar array requirements that are common to most GSFC spacecraft. Solar array technologies will be discussed that are currently under development and that could be useful to future GSFC spacecraft.

  10. Goddard Conference on Mass Storage Systems and Technologies, Volume 1

    NASA Technical Reports Server (NTRS)

    Kobler, Ben (Editor); Hariharan, P. C. (Editor)

    1993-01-01

    Copies of nearly all of the technical papers and viewgraphs presented at the Goddard Conference on Mass Storage Systems and Technologies held in Sep. 1992 are included. The conference served as an informational exchange forum for topics primarily relating to the ingestion and management of massive amounts of data and the attendant problems (data ingestion rates now approach the order of terabytes per day). Discussion topics include the IEEE Mass Storage System Reference Model, data archiving standards, high-performance storage devices, magnetic and magneto-optic storage systems, magnetic and optical recording technologies, high-performance helical scan recording systems, and low end helical scan tape drives. Additional topics addressed the evolution of the identifiable unit for processing purposes as data ingestion rates increase dramatically, and the present state of the art in mass storage technology.

  11. Fourth NASA Goddard Conference on Mass Storage Systems and Technologies

    NASA Technical Reports Server (NTRS)

    Kobler, Benjamin (Editor); Hariharan, P. C. (Editor)

    1994-01-01

    This report contains copies of all those technical papers received in time for publication just prior to the Fourth Goddard Conference on Mass Storage and Technologies, held March 28-30, 1995, at the University of Maryland, University College Conference Center, in College Park, Maryland. This series of conferences continues to serve as a unique medium for the exchange of information on topics relating to the ingestion and management of substantial amounts of data and the attendant problems involved. This year's discussion topics include new storage technology, stability of recorded media, performance studies, storage system solutions, the National Information infrastructure (Infobahn), the future for storage technology, and lessons learned from various projects. There also will be an update on the IEEE Mass Storage System Reference Model Version 5, on which the final vote was taken in July 1994.

  12. The NASA Goddard Space Flight Center Virtual Science Fair

    NASA Technical Reports Server (NTRS)

    Bolognese, Jeff; Walden, Harvey; Obenschain, Arthur F. (Technical Monitor)

    2002-01-01

    This report describes the development of the NASA Goddard Space Flight Center Virtual Science Fair, including its history and outgrowth from the traditional regional science fairs supported by NASA. The results of the 1999 Virtual Science Fair pilot program, the mechanics of running the 2000 Virtual Science Fair and its results, and comments and suggestions for future Virtual Science Fairs are provided. The appendices to the report include the original proposal for this project, the judging criteria, the user's guide and the judge's guide to the Virtual Science Fair Web site, the Fair publicity brochure and the Fair award designs, judges' and students' responses to survey questions about the Virtual Science Fair, and lists of student entries to both the 1999 and 2000 Fairs.

  13. A statistical analysis of the dependency of closure assumptions in cumulus parameterization on the horizontal resolution

    NASA Technical Reports Server (NTRS)

    Xu, Kuan-Man

    1994-01-01

    Simulated data from the UCLA cumulus ensemble model are used to investigate the quasi-universal validity of closure assumptions used in existing cumulus parameterizations. A closure assumption is quasi-universally valid if it is sensitive neither to convective cloud regimes nor to horizontal resolutions of large-scale/mesoscale models. The dependency of three types of closure assumptions, as classified by Arakawa and Chen, on the horizontal resolution is addressed in this study. Type I is the constraint on the coupling of the time tendencies of large-scale temperature and water vapor mixing ratio. Type II is the constraint on the coupling of cumulus heating and cumulus drying. Type III is a direct constraint on the intensity of a cumulus ensemble. The macroscopic behavior of simulated cumulus convection is first compared with the observed behavior in view of Type I and Type II closure assumptions using 'quick-look' and canonical correlation analyses. It is found that they are statistically similar to each other. The three types of closure assumptions are further examined with simulated data averaged over selected subdomain sizes ranging from 64 to 512 km. It is found that the dependency of Type I and Type II closure assumptions on the horizontal resolution is very weak and that Type III closure assumption is somewhat dependent upon the horizontal resolution. The influences of convective and mesoscale processes on the closure assumptions are also addressed by comparing the structures of canonical components with the corresponding vertical profiles in the convective and stratiform regions of cumulus ensembles analyzed directly from simulated data. The implication of these results for cumulus parameterization is discussed.

  14. Mitochondrial Dysfunction and Apoptosis in Cumulus Cells of Type I Diabetic Mice

    PubMed Central

    Wang, Qiang; Frolova, Antonina I.; Purcell, Scott; Adastra, Katie; Schoeller, Erica; Chi, Maggie M.; Schedl, Tim; Moley, Kelle H.

    2010-01-01

    Impaired oocyte quality has been demonstrated in diabetic mice; however, the potential pathways by which maternal diabetes exerts its effects on the oocyte are poorly understood. Cumulus cells are in direct contact with the oocyte via gap junctions and provide essential nutrients to support oocyte development. In this study, we investigated the effects of maternal diabetes on the mitochondrial status in cumulus cells. We found an increased frequency of fragmented mitochondria, a decreased transmembrane potential and an aggregated distribution of mitochondria in cumulus cells from diabetic mice. Furthermore, while mitochondrial biogenesis in cumulus cells was induced by maternal diabetes, their metabolic function was disrupted as evidenced by lower ATP and citrate levels. Moreover, we present evidence suggesting that the mitochondrial impairments induced by maternal diabetes, at least in part, lead to cumulus cell apoptosis through the release of cytochrome c. Together the deleterious effects on cumulus cells may disrupt trophic and signaling interactions with the oocyte, contributing to oocyte incompetence and thus poor pregnancy outcomes in diabetic females. PMID:21209947

  15. Effects of cumulus cells on rabbit oocyte in vitro maturation.

    PubMed

    Tao, Y; Cao, C; Zhang, M; Fang, F; Liu, Y; Zhang, Y; Ding, J; Zhang, X

    2008-08-01

    Cumulus cells (CCs) are of great importance in oocyte development and maturation in many species, but detailed influence of CCs has not been extensively examined, especially on rabbit. The present study was designed to investigate the effects of CCs and the elongation of in vitro maturation (IVM) time on rabbit oocyte nuclear and ooplasmic maturation and survival. Cumulus oocyte complexes (COCs) and naked oocytes (NOs) were recovered directly from rabbits super-ovulated with eCG. Corona-enclosed oocytes (COs) and denuded oocytes (DOs) were obtained from COCs after removing a part or whole of CCs. The oocytes were cultured in the following seven groups. (i) Cumulus cell enclosed oocytes (CEOs) were cultured alone (CEOs); (ii) COs were cultured alone (COs); (iii) DOs were cultured alone (DOs); (iv) NOs were cultured alone; (v) DOs were co-cultured with COCs [DOs(COCs)]; (vi) DOs were co-cultured with CCs [DOs(CCs)]; (vii) NOs were co-cultured with CCs [NOs(CCs)]. After the oocytes were cultured for 24 and 30 h, the nuclear maturation was evaluated by first polar body (PB1) extrusion while the ooplasmic maturation was evaluated by the cleavage rate after parthenogenetic activation. The results showed that the nuclear maturation rate of CEOs, COs, DOs(COCs) and DOs(CCs) after 24 h incubation were significantly different from each other (p < or = 0.05), the rate of DOs(CCs) was similar to that of DOs (p > or = 0.05). The cleavage rates in the first two groups were significantly higher than those of the others (p < 0.05). For oocytes cultured for 30 h, the nuclear maturation rates were significantly different for each culture model (p < 0.05). The cleavage rates in first two groups were significantly higher than those of others (p < 0.05). Both the nuclear and cleavage rates significantly increased when the culture time of DOs(COCs) was prolonged from 24 to 30 h. DOs(CCs) nuclear maturation was significantly improved when the culture time was prolonged from 24 to 30 h

  16. 9-cis Retinoic acid inhibits cumulus cell apoptosis during the maturation of bovine cumulus-oocyte-complexes.

    PubMed

    Deb, G K; Dey, S R; Bang, J I; Lee, J G; Kong, I K

    2012-06-01

    Cumulus cell (CC) apoptosis is inversely correlated with embryonic development in vitro. Therefore, inhibition of CC apoptosis is important for proper embryonic development and quality. Retinoic acids (all-transRA and 9-cisRA) are natural components of retinoids, and 9-cisRA is the physiologically active metabolite of retinoic acid in vitro. During in vitro maturation, 9-cisRA enhances oocyte competence through multiple mechanisms affecting the oocyte and preimplantation embryo; however, the effect of 9-cisRA on CC apoptosis has yet to be elucidated. The aim of the present study was to evaluate the effect of 9-cisRA on CC apoptosis and to identify the molecular mechanism underlying that effect. Bovine slaughterhouse cumulus-oocyte complexes (COC) were matured in vitro in the absence or presence of 5 nM 9-cisRA. Cumulus cells were collected from immature and matured COC for the detection of apoptosis and gene expression analysis. Results showed that 9-cisRA reduced the number of apoptotic CC by about 2.7 fold (P < 0.023), compared with control. However, apoptosis is rare in CC of immature COC (0.01% ± 0.001). Transcripts involved in the caspase cascade were down-regulated upon exposure to 9-cisRA, including tumor necrosis factor alpha (TNF-α, 11.1 fold, P < 0.001), tumor necrosis factor alpha receptor 1 (TNFR1, 2.3 fold, P < 0.01), caspase 9 (CASP9, 2.0 fold, P < 0.031), caspase 8 (CASP8, 2.2 fold, P < 0.012), and caspase 3 (CASP3, 2.1 fold, P < 0.006), while antiapoptotic B-cell lymphoma 2 (BCL2) transcript was increased (3.1 fold, P < 0.004), compared with control. In addition, 9-cisRA inhibited mitogen activated protein kinase mRNA expression in CC, including extracellular signal-regulated kinase 1/2 (ERK1, 2.7 fold, P < 0.02; ERK2, 2.7 fold, P < 0.03), and c-Jun N-terminal kinase (JNK, 1.6 fold, P < 0.044), as well as the activator protein-1 (AP1) family members c-jun (1.6 fold, P < 0.041) and c-fos (2.0 fold, P < 0.06). The transcript abundances of TNF

  17. Shallow Cumulus Sensitivity to Aerosol within a Fixed Meteorology Framework (Invited)

    NASA Astrophysics Data System (ADS)

    Seigel, R. B.

    2013-12-01

    Shallow cumulus clouds are critically important to the global energy budget and the general circulation of the earth. These clouds occupy up to a quarter of the global cloud fraction and they play a crucial role in mixing boundary layer properties with the free troposphere. As such, shallow cumulus clouds have a large effect on the vertical thermodynamic structure of the lower atmosphere, which then directly impacts larger scale circulations. Therefore, changes to the vertical mixing rates of cumulus clouds by forcing mechanisms such as aerosol loading can result in significant consequences for the general circulation of the Earth. This study aims to isolate changes in cumulus vertical mixing by a single forcing mechanism - aerosol loading. In order to isolate aerosol induced changes in cumulus mixing that are solely due to microphysical-dynamical interactions and not from mean-state thermodynamic instability changes caused by aerosol-cloud-precipitation feedbacks, this study uses a new approach of forcing shallow cumulus clouds in large eddy simulations (LESs). Nine (9) LESs with systematic variations in aerosol concentration and model domain size are initialized with the well-studied trade cumulus regime of the Barbados Oceanographic and Meteorological Experiment (BOMEX). However, rather than using the standard BOMEX forcing functions for each of the nine (9) simulations, which can result in different mean thermodynamic states when variations in aerosol concentration are imposed, the horizontal mean states of the following four (4) model prognosed variables are held fixed: liquid potential temperature (θl), total water (qt), zonal wind (u) and meridional wind (v). This guarantees that all variations of the cloud populations and their role in mixing are strictly the result of local microphysical-dynamical changes that result from changes in aerosol concentrations and not from changes to bulk conditional instability. Results from the nine (9) simulations show

  18. NKG2D ligands as therapeutic targets

    PubMed Central

    Spear, Paul; Wu, Ming-Ru; Sentman, Marie-Louise; Sentman, Charles L.

    2013-01-01

    The Natural Killer Group 2D (NKG2D) receptor plays an important role in protecting the host from infections and cancer. By recognizing ligands induced on infected or tumor cells, NKG2D modulates lymphocyte activation and promotes immunity to eliminate ligand-expressing cells. Because these ligands are not widely expressed on healthy adult tissue, NKG2D ligands may present a useful target for immunotherapeutic approaches in cancer. Novel therapies targeting NKG2D ligands for the treatment of cancer have shown preclinical success and are poised to enter into clinical trials. In this review, the NKG2D receptor and its ligands are discussed in the context of cancer, infection, and autoimmunity. In addition, therapies targeting NKG2D ligands in cancer are also reviewed. PMID:23833565

  19. Aerosol-induced mechanisms for cumulus congestus growth

    NASA Astrophysics Data System (ADS)

    Sheffield, Amanda M.; Saleeby, Stephen M.; Heever, Susan C.

    2015-09-01

    Tropical convection has been observed to contain three cloud modes, the middle of which is cumulus congestus clouds. Congestus clouds act to moisten the tropical atmosphere, may be mixed-phase, and on occasion surpass the freezing level inversion from where they may develop into deeper convection. This study investigates the impacts of enhanced aerosol concentrations on the growth of congestus clouds produced in idealized cloud-resolving model simulations run under a state of radiative convective equilibrium (RCE). High-resolution, long-duration simulations were completed using the Regional Atmospheric Modeling System (RAMS). Aerosol concentrations between 2 and 4 km above ground level were varied from clean to polluted conditions in order to represent the advection of Saharan dust over the Atlantic Ocean. The congestus populations within each aerosol simulation are statistically analyzed using 10 days of model output after the simulation reaches RCE. Results indicate that congestus in more polluted conditions produce greater amounts of cloud water and ice mass, enhanced updraft strengths, and an increase in the number of congestus cloud tops that extend above the freezing level. Enhanced vapor depositional growth on the populations of more numerous, smaller cloud droplets in the polluted conditions, and the subsequent increase in latent heat release in the warm phase regions of the cloud, is found to be important factors in convective invigoration of these cloud systems. Aerosol feedbacks associated with cold pools and condensate loading also influence the updraft strength and act in opposition to the warm phase invigoration processes.

  20. Scale dependence of entrainment-mixing mechanisms in cumulus clouds

    DOE PAGESBeta

    Lu, Chunsong; Liu, Yangang; Niu, Shengjie; Endo, Satoshi

    2014-12-17

    This work empirically examines the dependence of entrainment-mixing mechanisms on the averaging scale in cumulus clouds using in situ aircraft observations during the Routine Atmospheric Radiation Measurement Aerial Facility Clouds with Low Optical Water Depths Optical Radiative Observations (RACORO) field campaign. A new measure of homogeneous mixing degree is defined that can encompass all types of mixing mechanisms. Analysis of the dependence of the homogenous mixing degree on the averaging scale shows that, on average, the homogenous mixing degree decreases with increasing averaging scales, suggesting that apparent mixing mechanisms gradually approach from homogeneous mixing to extreme inhomogeneous mixing with increasingmore » scales. The scale dependence can be well quantified by an exponential function, providing first attempt at developing a scale-dependent parameterization for the entrainment-mixing mechanism. The influences of three factors on the scale dependence are further examined: droplet-free filament properties (size and fraction), microphysical properties (mean volume radius and liquid water content of cloud droplet size distributions adjacent to droplet-free filaments), and relative humidity of entrained dry air. It is found that the decreasing rate of homogeneous mixing degree with increasing averaging scales becomes larger with larger droplet-free filament size and fraction, larger mean volume radius and liquid water content, or higher relative humidity. The results underscore the necessity and possibility of considering averaging scale in representation of entrainment-mixing processes in atmospheric models.« less

  1. Scale dependence of entrainment-mixing mechanisms in cumulus clouds

    SciTech Connect

    Lu, Chunsong; Liu, Yangang; Niu, Shengjie; Endo, Satoshi

    2014-12-17

    This work empirically examines the dependence of entrainment-mixing mechanisms on the averaging scale in cumulus clouds using in situ aircraft observations during the Routine Atmospheric Radiation Measurement Aerial Facility Clouds with Low Optical Water Depths Optical Radiative Observations (RACORO) field campaign. A new measure of homogeneous mixing degree is defined that can encompass all types of mixing mechanisms. Analysis of the dependence of the homogenous mixing degree on the averaging scale shows that, on average, the homogenous mixing degree decreases with increasing averaging scales, suggesting that apparent mixing mechanisms gradually approach from homogeneous mixing to extreme inhomogeneous mixing with increasing scales. The scale dependence can be well quantified by an exponential function, providing first attempt at developing a scale-dependent parameterization for the entrainment-mixing mechanism. The influences of three factors on the scale dependence are further examined: droplet-free filament properties (size and fraction), microphysical properties (mean volume radius and liquid water content of cloud droplet size distributions adjacent to droplet-free filaments), and relative humidity of entrained dry air. It is found that the decreasing rate of homogeneous mixing degree with increasing averaging scales becomes larger with larger droplet-free filament size and fraction, larger mean volume radius and liquid water content, or higher relative humidity. The results underscore the necessity and possibility of considering averaging scale in representation of entrainment-mixing processes in atmospheric models.

  2. Rainfall results, 1970-1975: Florida area cumulus experiment.

    PubMed

    Woodley, W L; Simpson, J; Biondini, R; Berkeley, J

    1977-02-25

    The latest rainfall results of the Florida Area Cumulus Experiment (FACE) are discussed after a review of the background, design, and early results of this experiment. Analysis without the benefit of data stratification and appropriate covariates of the 48 random experimentation days obtained through 1975 provided no evidence that dynamic seeding appreciably altered the rainfall over the fixed target area (1.3 x 10(4) square kilometers). Partitioning of the experimentation days according to whether the convective echoes moved across the Florida peninsula or developed in situ was more informative. Use of this echo motion covariate with five meaningful predictor models of natural rainfall in a stepwise regression program produced persuasive evidence for an effect of seeding in both echo motion categories. For days with moving echoes, there is evidence for a positive, statistically significant treatment effect on the rainfall from the subject clouds (the floating target) and in the overall target area. The results for days with stationary echoes, although considerably more tentative, suggest that seeding produces more rainfall in the floating target but with no net change of the precipitation in the overall target area. The ramifications of this result and a possible explanation are discussed. Corroborative statistical analyses and discussion are presented, including a discussion of the physical bases and history of the echo motion covariate and the meteorological predictors, analysis that is supportive of the rain-gage-adjusted radar measurements of precipitation in FACE and results of relevant cloud physics measurements in Florida. PMID:17788851

  3. Entrainment and detrainment in a simple cumulus cloud model

    NASA Technical Reports Server (NTRS)

    Randall, D. A.; Huffman, G. J.

    1982-01-01

    A cumulus cloud model, analogous to the mixed-layer models of the planetary boundary layer and the upper ocean, is developed using a single, unitary entrainment process in which the motion of the cloud boundary relative to the mean flow is permitted, produced, and controlled by turbulent processes. An alternate theory to the mixing-length theory of Asai and Kasahara (1967) is proposed which completely removes the strong scale-dependence of the Asai-Kasahara model. The model reintroduces scale-dependence by introducing including the pe5turbation pressure term of the equation of vertical motion. It is shown that the model predicts deeper clouds than the Asai-Kasahara model for a given sounding, due to the entrainment assumption and the effects of the perturbation pressure. Lateral entrainment dominates cloud-top entrainment, although finite-difference errors increase the cloud-top entrainment rate from zero to a positive value in actual situations. The fractional entrainment rate for updrafts is determined to vary only slightly with height and to decrease only slowly as the cloud radius increases, while the fractional detrainment rate for updrafts increases with height.

  4. AIRS Data Support at NASA Goddard Earth Science DISC DAAC

    NASA Astrophysics Data System (ADS)

    Cho, S.; Qin, J.; Sharma, A.

    2002-05-01

    The Atmospheric Infrared Sounder (AIRS) is selected by NASA to fly on the second Earth Observing System (EOS) polar orbiting platform, EOS Aqua, which is launched in April 2002. AIRS, together with Advanced Microwave Sounding Unit (AMSU) and Humidity Sounder for Brazil (HSB), is designed to meet the requirements of the NASA Earth Science Enterprise climate research program and the NOAA operational weather forecasting The data products from the AIRS/AMSU/HSB will be archived and distributed at the Goddard Distributed Active Archive Center (GDAAC) located in the NASA Goddard Earth Sciences Data and Information Services Center (GES DAAC) in later 2002. This new dataset consists of radiances, geo-locations and atmospheric products, such as, temperature, humidity, cloud and ozone, providing measurements for temperature at an accuracy of 1 o C in layers 1 km thick and humidity with an accuracy of 20 % in layers 2 km thick in the troposphere. The data will be freely available via WWW interfaces, or an FTP containing subsetted and reformatted data products. The GES DISC DAAC Search and Order allows users to search for data by following particular paths down the hierarchy. This simple point-and- click navigational web interface shows temporal and spatial coverage, item size, description and browse images for AIRS data and one can customize search using spatial,temporal, attribute and parameter search. The EOS Data Gateway (EDG) is another user interface for searching and ordering the AIRS data together with other data products obtained from EOS instruments. The Atmospheric Dynamics Data Support Team (ADDST) at the GES DISC/DAAC will provide various services to assist users in understanding, accessing, and using AIRS data product. The ADDST has been developing tools to read, visualize and analyze the AIRS data, channel/parameter subsetting of AIRS HDF-EOS data products and supplying documentation and readme et al. Other services provided by the ADDST will contain assistance

  5. Field Experiment Data Support at the Goddard DAAC

    NASA Astrophysics Data System (ADS)

    Hrubiak, P. L.; Yang, R.; Ahmad, S.; Chiu, L.; Teng, W.; Liu, Z.; Serafino, G.; Rui, H.; Bonk, J.; Pollack, N.

    2001-12-01

    Historically, field experiment data support at the data center level has been sketchy, but in the last decade, because of rapid growth of electronic capabilities throughout the science community, the data center has become the resolution of choice to the problems of campaign data distribution and archival. Even so, field campaign data, being inherently non-uniform, require significant adaptation on the part of the archive. The participant complement for a campaign ranges widely-from one to three dozen investigators. Each has his/her own instrument, organizational affiliation, and funding. Many are academics with class schedules to consider, an office staff composed of graduate students and a correspondingly high turnover rate. Some are operating with very limited resources and lack the programming staff to tailor their data to archive specifications. Data delivery schedules, formatting and documentation are all driven by these factors. Planning for data volume also requires flexibility. Campaign data acquisition is sensitive to weather and a variety of logistical problems. Planning for campaign data volume is therefore a matter of determining thresholds. Since most campaign data sets tend to be small by data center standards, distribution is mainly from anonymous ftp sites front-ended by web sites. The Goddard DAAC opened its campaign archive in 1994 with data from the TRMM oriented TOGA-COARE campaign of 1992-93, and has most recently archived the TRMM global validation campaigns, designed to evaluate the physical assumptions made by TRMM rainfall algorithms, initialize and validate the cloud resolving models, test latent heating retrievals from TRMM measurements, and evaluate methods to estimate rainfall and latent heating from ground based radars. Launched by the TRMM Office in 1998, the TRMM campaigns were designed as a group so that specific measurements could be compared between experiments in order to gain insight into the regional dependence of any findings

  6. The vertical structure of diabatic heating associated with the Madden-Julian oscillation simulated by the Goddard Laboratory for Atmospheres climate model

    NASA Technical Reports Server (NTRS)

    Chen, Tsing-Chang; Yen, Ming-Cheng; Pfaendtner, James; Sud, Y. C.

    1993-01-01

    The diabatic heating structure of the nine-layer Goddard Laboratory for Atmospheres model of the Madden-Julian oscillation (MJO) is illustrated with composite charts made for those times when this low-frequency mode reaches its maximum and minimum amplitudes. These composite charts compare the vertically integrated diabatic heating with potential functions, the vertical distribution of diabatic heating with the east-west mass flux function in the tropics, and the vertical profiles of diabatic heating at the centers of maximum and minimum MJO amplitude. Three interesting features of the model MJO's diabatic heating are revealed: (1) the maximum heating rate of this low-frequency mode is located over the Asian monsoon region and its amplitude is about a half of the maximum value of the seasonal mean heating rate in this region, (2) the vertical diabatic heating rate profile has a maximum at 500 mbar and resembles the seasonal mean total heating profile, and (3) the total diabatic heating is for the most part composed of the latent heat released by cumulus convection.

  7. Molecular analysis of the cumulus matrix: insights from mice with O-glycan-deficient oocytes.

    PubMed

    Ploutarchou, Panayiota; Melo, Pedro; Day, Anthony J; Milner, Caroline M; Williams, Suzannah A

    2015-05-01

    During follicle development, oocytes secrete factors that influence the development of granulosa and cumulus cells (CCs). In response to oocyte and somatic cell signals, CCs produce extracellular matrix (ECM) molecules resulting in cumulus expansion, which is essential for ovulation, fertilisation, and is predictive of oocyte quality. The cumulus ECM is largely made up of hyaluronan (HA), TNF-stimulated gene-6 (TSG-6, also known as TNFAIP6), pentraxin-3 (PTX3), and the heavy chains (HCs) of serum-derived inter-α-inhibitor proteins. In contrast to other in vivo models where modified expansion impairs fertility, the cumulus mass of C1galt1 Mutants, which have oocyte-specific deletion of core 1-derived O-glycans, is modified without impairing fertility. In this report, we used C1galt1 Mutant (C1galt1(FF):ZP3Cre) and Control (C1galt1(FF)) mice to investigate how cumulus expansion is affected by oocyte-specific deletion of core 1-derived O-glycans without adversely affecting oocyte quality. Mutant cumulus-oocyte complexes (COCs) are smaller than Controls, with fewer CCs. Interestingly, the CCs in Mutant mice are functionally normal as each cell produced normal levels of the ECM molecules HA, TSG-6, and PTX3. However, HC levels were elevated in Mutant COCs. These data reveal that oocyte glycoproteins carrying core 1-derived O-glycans have a regulatory role in COC development. In addition, our study of Controls indicates that a functional COC can form provided all essential components are present above a minimum threshold level, and thus some variation in ECM composition does not adversely affect oocyte development, ovulation or fertilisation. These data have important implications for IVF and the use of cumulus expansion as a criterion for oocyte assessment. PMID:25855670

  8. Proteomics-Based Systems Biology Modeling of Bovine Germinal Vesicle Stage Oocyte and Cumulus Cell Interaction

    PubMed Central

    Peddinti, Divyaswetha; Memili, Erdogan; Burgess, Shane C.

    2010-01-01

    Background Oocytes are the female gametes which establish the program of life after fertilization. Interactions between oocyte and the surrounding cumulus cells at germinal vesicle (GV) stage are considered essential for proper maturation or ‘programming’ of oocytes, which is crucial for normal fertilization and embryonic development. However, despite its importance, little is known about the molecular events and pathways involved in this bidirectional communication. Methodology/Principal Findings We used differential detergent fractionation multidimensional protein identification technology (DDF-Mud PIT) on bovine GV oocyte and cumulus cells and identified 811 and 1247 proteins in GV oocyte and cumulus cells, respectively; 371 proteins were significantly differentially expressed between each cell type. Systems biology modeling, which included Gene Ontology (GO) and canonical genetic pathway analysis, showed that cumulus cells have higher expression of proteins involved in cell communication, generation of precursor metabolites and energy, as well as transport than GV oocytes. Our data also suggests a hypothesis that oocytes may depend on the presence of cumulus cells to generate specific cellular signals to coordinate their growth and maturation. Conclusions/Significance Systems biology modeling of bovine oocytes and cumulus cells in the context of GO and protein interaction networks identified the signaling pathways associated with the proteins involved in cell-to-cell signaling biological process that may have implications in oocyte competence and maturation. This first comprehensive systems biology modeling of bovine oocytes and cumulus cell proteomes not only provides a foundation for signaling and cell physiology at the GV stage of oocyte development, but are also valuable for comparative studies of other stages of oocyte development at the molecular level. PMID:20574525

  9. Transcriptomic Diversification of Developing Cumulus and Mural Granulosa Cells in Mouse Ovarian Follicles1

    PubMed Central

    Wigglesworth, Karen; Lee, Kyung-Bon; Emori, Chihiro; Sugiura, Koji; Eppig, John J.

    2014-01-01

    ABSTRACT Cumulus cells and mural granulosa cells (MGCs) have functionally distinct roles in antral follicles, and comparison of their transcriptomes at a global and systems level can propel future studies on mechanisms underlying their functional diversity. These cells were isolated from small and large antral follicles before and after stimulation of immature mice with gonadotropins, respectively. Both cell types underwent dramatic transcriptomic changes, and differences between them increased with follicular growth. Although cumulus cells of both stages of follicular development are competent to undergo expansion in vitro, they were otherwise remarkably dissimilar with transcriptomic changes quantitatively equivalent to those of MGCs. Gene ontology analysis revealed that cumulus cells of small follicles were enriched in transcripts generally associated with catalytic components of metabolic processes, while those from large follicles were involved in regulation of metabolism, cell differentiation, and adhesion. Contrast of cumulus cells versus MGCs revealed that cumulus cells were enriched in transcripts associated with metabolism and cell proliferation while MGCs were enriched for transcripts involved in cell signaling and differentiation. In vitro and in vivo models were used to test the hypothesis that higher levels of transcripts in cumulus cells versus MGCs is the result of stimulation by oocyte-derived paracrine factors (ODPFs). Surprisingly ∼48% of transcripts higher in cumulus cells than MGCs were not stimulated by ODPFs. Those stimulated by ODPFs were mainly associated with cell division, mRNA processing, or the catalytic pathways of metabolism, while those not stimulated by ODPFs were associated with regulatory processes such as signaling, transcription, phosphorylation, or the regulation of metabolism. PMID:25376232

  10. Goddard Space Flight Center Spacecraft Magnetic Test Facility Restoration Project

    NASA Technical Reports Server (NTRS)

    Vernier, Robert; Bonalksy, Todd; Slavin, James

    2004-01-01

    The Goddard Space Flight Center Spacecraft Magnetic Test Facility (SMTF) was constructed in the 1960's for the purpose of simulating geomagnetic and interplanetary magnetic field environments. The facility includes a three axis Braunbek coil system consisting of 12 loops, 4 loops on each of the three orthogonal axes; a remote earth field sensing magnetometer and servo control building; and a remote power control and instrumentation building. The inner coils are 42-foot in diameter and a 10-foot by 10-foot opening through the outer coils accommodates spacecraft access to the test volume. The physical size and precision of the facility are matched by only two other such facilities in the world. The facility was used extensively from the late 1960's until the early 1990's when the requirement for spacecraft level testing diminished. New NASA missions planned under the Living with a Star, Solar Terrestrial Probes, Explorer, and New Millennium Programs include precision, high-resolution magnetometers to obtain magnetic field data that is critical to fulfilling their scientific mission. It is highly likely that future Lunar and Martian exploration missions will also use precision magnetometers to conduct geophysical magnetic surveys. To ensure the success of these missions ground testing using a magnetic test facility such as the GSFC SMTF will be required. This paper describes the history of the facility, the future mission requirements that have renewed the need for spacecraft level magnetic testing, and the plans for restoring the facility to be capable of performing to its original design specifications.

  11. Goddard High Resolution Spectrograph SV/GTO Project

    NASA Technical Reports Server (NTRS)

    Ebbets, Dennis

    1999-01-01

    Contract number NAS5-30433, known at Ball Aerospace as the GHRS SV/GTO project, supported our participation in the post-launch activities of the Goddard High Resolution Spectrograph aboard the Hubble Space Telescope. The period of performance was December 1988 through December 1998. The contract supported the involvement of Dr Dennis Ebbets in the work of the GHRS Investigation Definition Team, and several of the Ball people in the documentation and publication of results. Three main categories of tasks were covered by this contract; in-orbit calibration of the GHRS, guaranteed time observations, and education and public outreach. The nature and accomplishments of these tasks are described in the report. This summary makes many references to publications in the scientific and technical literature. Appendix A is extracted from a complete bibliography, and lists those papers that are directly related to work performed under this GHRS contract. The tasks related to the in-orbit calibration of the GHRS were by far the largest responsibility during the first six years of the project. During this period Dr. Ebbets was responsible for the definition of calibration requirements, design of experiments, preparation of observing proposals, tracking their implementation and execution, and coordinating the analysis and publication of the results. Prior to the launch of HST in 1990 the observing proposals were developed in cooperation with the scientists on the GHRS DDT, engineers at Ball Aerospace, the operations staff at the STScI, and project coordinators at GSFC.

  12. An improved gravity model for Mars: Goddard Mars Model 1

    NASA Technical Reports Server (NTRS)

    Smith, D. E.; Lerch, F. J.; Nerem, R. S.; Zuber, M. T.; Patel, G. B.; Fricke, S. K.; Lemoine, F. G.

    1993-01-01

    Doppler tracking data of three orbiting spacecraft have been reanalyzed to develop a new gravitational field model for the planet Mars, Goddard Mars Model 1 (GMM-1). This model employs nearly all available data, consisting of approximately 1100 days of S band tracking data collected by NASA's Deep Space Network from the Mariner 9 and Viking 1 and Viking 2 spacecraft, in seven different orbits, between 1971 and 1979. GMM-1 is complete to spherical harmonic degree and order 50, which corresponds to a half-wavelength spatial resolution of 200-300 km where the data permit. GMM-1 represents satellite orbits with considerably better accuracy than previous Mars gravity models and shows greater resolution of identifiable geological structures. The notable improvement in GMM-1 over previous models is a consequence of several factors: improved computational capabilities, the use of otpimum weighting and least squares collocation solution techniques which stabilized the behavior of the solution at high degree and order, and the use of longer satellite arcs than employed in previous solutions that were made possible by improved force and measurement models. The inclusion of X band tracking data from the 379-km altitude, nnear-polar orbiting Mars Observer spacecraft should provide a significant improvement over GMM-1, particularly at high latitudes where current data poorly resolve the gravitational signature of the planet.

  13. Prototype software reuse environment at Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Truszkowski, Walt

    1989-01-01

    The Goddard Space Flight Center (GSFC) work is organized into four phases and includes participation by a contractor, CTA, Inc. The first phase was an automation study, which began with a comprehensive survey of software development automation technologies. Eight technical areas were analyzed for goals, current capabilities, and obstacles. The study documented current software development practice in GSFC Mission Operations and Data Systems Directorate, and presented short- and long-term recommendations that included focus on reuse and object-oriented development. The second phase, which has been completed, developed a prototype reuse environment with tools supporting object-oriented requirements analysis and design. This phase addressed the operational concept of software reuse, i.e., it attempted to understand how software can be reused. This environment has two semantic networks: object and keywords, and includes automated search, interactive browsing and a graphical display of database contents. Phase 3 was a domain analysis of Payload Operations Control Center (POCC) software. The goal in this phase was to create an initial repository of reusable components and techniques. Seven existing Operations Control Centers at GSFC were studied, but the domain analysis proved to be very slow. A lesson learned from this was that senior people who understand the environment and the functionality of the area are needed to perform successful domain analyses.

  14. Orbital Anomalies in Goddard Spacecraft for Calendar Year 1994

    NASA Technical Reports Server (NTRS)

    Thomas, Walter B.

    1996-01-01

    This report summarizes and updates the annual on-orbit performance between January I and December 31, 1994, for spacecraft built by or managed by the Goddard Space Flight Center (GSFC). During 1994, GSFC had 27 active orbiting satellites and I Shuttle-launched and retrieved 'free flyer.' There were 310 reported anomalies among 21 satellites and one GSFC instrument (TOMS). GOES-8 accounted for 66 anomalies, and SAMPES reported 155 'anomalies'. Of the 155 anomalies reported for all but SAMPEX, only 4 affected the spacecraft missions 'substantially' or greater, that is, presented a loss of more than 33% of the total missions. The most frequent subsystem anomalies were Instrument/Payload(44), Timing Command and Control(40), and Attitude Control Systems(33). Of the non-SAMPEX anomalies, 29% had no effect on the missions and 28% caused subsystem or instrument degradation and, for another 28%, no anomaly effect on the mission could be determined. Fifty-three percent of non-SAMPEX anomalies could not be classified according to 'type'; the other most common types were 'systemic'(35), 'random'(19), and 'normal or expected operation'(15). Forty percent of the anomalies were not classified according to failure category; the remaining most frequent occurrences were 'design problems'(50) and 'other known problems'(35).

  15. Distribution of MODIS Data at the Goddard Earth Sciences DAAC

    NASA Astrophysics Data System (ADS)

    Sharma, A. K.

    2001-12-01

    As a part of the NASA's Earth Observing System (EOS) mission, the Terra satellite was launched in December 1999 to investigate global climate changes. One of the five instruments on Terra is the Moderate Resolution Imaging Spectroradiometer (MODIS). The Goddard Earth Sciences Distributed Active Archive Center (GES DAAC) is responsible for ingesting, processing, archiving, and distribution of quality climate data derived from the MODIS. Currently the GES DAAC is distributing MODIS data at a rate of about 500 Gigabytes per day. Access to MODIS products archived at GES DAAC is through the Web-based Hierarchical Ordering Mechanism (WHOM) and the EOS Data Gateway (EDG). These tools are simple to use and allow users to search, browse and order MODIS data products. In addition to these tools subscription services are currently used by the MODIS Science Team for calibration and validation purposes. This presentation will seek to answer various questions users might have regarding MODIS data and various capabilities available to users to search and order data products. Future plans of the GES DAAC for distributing data in a more efficient and timely manner will be presented. One of the plans allows users a quick way of accessing data through the Data Pool which is a large on-line cache. Data available on the Data Pool can be reviewed for fast delivery. The Data Services associated with the Data Pool such as search metadata, browse, and subset will be discussed.

  16. Goddard Space Flight Center's Structural Dynamics Data Acquisition System

    NASA Technical Reports Server (NTRS)

    McLeod, Christopher

    2004-01-01

    Turnkey Commercial Off The Shelf (COTS) data acquisition systems typically perform well and meet most of the objectives of the manufacturer. The problem is that they seldom meet most of the objectives of the end user. The analysis software, if any, is unlikely to be tailored to the end users specific application; and there is seldom the chance of incorporating preferred algorithms to solve unique problems. Purchasing a customized system allows the end user to get a system tailored to the actual application, but the cost can be prohibitive. Once the system has been accepted, future changes come with a cost and response time that's often not workable. When it came time to replace the primary digital data acquisition system used in the Goddard Space Flight Center's Structural Dynamics Test Section, the decision was made to use a combination of COTS hardware and in-house developed software. The COTS hardware used is the DataMAX II Instrumentation Recorder built by R.C. Electronics Inc. and a desktop Pentium 4 computer system. The in-house software was developed using MATLAB from The MathWorks. This paper will describe the design and development of the new data acquisition and analysis system.

  17. Goddard Space Flight Center's Structural Dynamics Data Acquisition System

    NASA Technical Reports Server (NTRS)

    McLeod, Christopher

    2004-01-01

    Turnkey Commercial Off The Shelf (COTS) data acquisition systems typically perform well and meet most of the objectives of the manufacturer. The problem is that they seldom meet most of the objectives of the end user. The analysis software, if any, is unlikely to be tailored to the end users specific application; and there is seldom the chance of incorporating preferred algorithms to solve unique problems. Purchasing a customized system allows the end user to get a system tailored to the actual application, but the cost can be prohibitive. Once the system has been accepted, future changes come with a cost and response time that's often not workable. When it came time to replace the primary digital data acquisition system used in the Goddard Space Flight Center's Structural Dynamics Test Section, the decision was made to use a combination of COTS hardware and in-house developed software. The COTS hardware used is the DataMAX II Instrumentation Recorder built by R.C. Electronics Inc. and a desktop Pentium 4 computer system. The in-house software was developed using MATLAF3 from The Mathworks. This paper will describe the design and development of the new data acquisition and analysis system.

  18. Earth alert: a NASA Goddard tech transfer success story

    NASA Astrophysics Data System (ADS)

    McGraw, Thomas F.

    1994-10-01

    The historically high toll in human lives lost to natural disasters such as hurricanes, tornadoes, floods, and other progressive events signals the need for some type of personal warning that alerts people to the need to evacuate or otherwise protect themselves in the face of an advancing threat. Traditional warning services, which rely on broadcasts by the mass media in the metropolitan areas of the United States, achieve measurable success in disseminating warnings. However, warnings to isolated populations that exist in the U.S. and elsewhere in the world may be poor to effectively nonexistent, especially in the many archipelagoes. Earth Alert, a joint project of NASA Goddard Space Flight Center and Scientific and Commercial Systems Corporation, is targeted at development of a simple, low-cost means for providing timely warning to otherwise isolated populations. The project uses appropriate relay capabilities of U.S. satellites already in orbit, and thus avoids the high-cost development and launch of dedicated resources.

  19. Perspectives for spintronics in 2D materials

    NASA Astrophysics Data System (ADS)

    Han, Wei

    2016-03-01

    The past decade has been especially creative for spintronics since the (re)discovery of various two dimensional (2D) materials. Due to the unusual physical characteristics, 2D materials have provided new platforms to probe the spin interaction with other degrees of freedom for electrons, as well as to be used for novel spintronics applications. This review briefly presents the most important recent and ongoing research for spintronics in 2D materials.

  20. Robust, Radiation Tolerant Command and Data Handling and Power System Electronics from NASA Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Nguyen, Hanson C.; Fraction, James; Ortiz-Acosta, Melyane; Dakermanji, George; Kercheval, Bradford P.; Hernandez-Pellerano, Amri; Kim, David S.; Jung, David S.; Meyer, Steven E.; Mallik, Udayan; Rush, Kurt D.; Farid, Faramarz; Olsen, James C.; Sparacino, Pietro A.

    2016-01-01

    The Goddard Modular Smallsat Architecture (GMSA) is developed at NASA Goddard Space Flight Center (GSFC) to address future reliability along with minimizing cost and schedule challenges for NASA Cubesat and Smallsat missions.

  1. Analysis of Cumulus Solar Irradiance Reflectance (CSIR) Events

    NASA Technical Reports Server (NTRS)

    Laird, John L.; Harshvardham

    1996-01-01

    Clouds are extremely important with regard to the transfer of solar radiation at the earth's surface. This study investigates Cumulus Solar Irradiance Reflection (CSIR) using ground-based pyranometers. CSIR events are short-term increases in solar radiation observed at the surface as a result of reflection off the sides of convective clouds. When sun-cloud observer geometry is favorable, these occurrences produce characteristic spikes in the pyranometer traces and solar irradiance values may exceed expected clear-sky values. Ultraviolet CSIR events were investigated during the summer of 1995 using Yankee Environmental Systems UVA-1 and UVB-1 pyranometers. Observed data were compared to clear-sky curves which were generated using a third degree polynomial best-fit line technique. Periods during which the observed data exceeded this clear-sky curve were identified as CSIR events. The magnitude of a CSIR event was determined by two different quantitative calculations. The MAC (magnitude above clear-sky) is an absolute measure of the difference between the observed and clear-sky irradiances. Maximum MAC values of 3.4 Wm(exp -2) and 0.069 Wm(exp -2) were observed at the UV-A and UV-B wavelengths, respectively. The second calculation determined the percentage above clear-sky (PAC) which indicated the relative magnitude of a CSIR event. Maximum UV-A and UV-B PAC magnitudes of 10.1% and 7.8%, respectively, were observed during the study. Also of interest was the duration of the CSIR events which is a function of sun-cloud-sensor geometry and the speed of cloud propagation over the measuring site. In both the UV-A and UV-B wavelengths, significant CSIR durations of up to 30 minutes were observed.

  2. Analysis of cumulus solar irradiance reflectance (CSIR) events

    NASA Astrophysics Data System (ADS)

    Laird, John L.; Harshvardhan

    Clouds are extremely important with regard to the transfer of solar radiation at Earth's surface. This study investigates Cumulus Solar Irradiance Reflection (CSIR) using ground-based pyranometers. CSIR events are short-term increases in solar radiation observed at the surface as a result of reflection off the sides of convective clouds. When Sun-cloud observer geometry is favorable, these occurrences produce characteristic spikes in the pyranometer traces and solar irradiance values may exceed expected clear-sky values. Ultraviolet CSIR events were investigated during the summer of 1995 using UVA and UVB pyranometers. Observed data were compared to clear-sky curves which were generated using a third degree polynomial best-fit line technique. Periods during which the observed data exceeded this clear-sky curve were identified as CSIR events. The magnitude of a CSIR event was determined by two different quantitative calculations. The MAC (magnitude above clear-sky) is an absolute measure of the difference between the observed and clear-sky irradiances. Maximum MAC values of 3.4 Win -2 and 0.0169 Wm -2 were observed at the UV-A and UV-B wavelengths, respectively. The second calculation determined the percentage above clear-sky (PAC) which indicated the relative magnitude of a CSIR event. Maximum UV-A and UV-B PAC magnitudes of 10.1% and 7.8%, respectively, were observed during the study. Also of interest was the duration of the CSIR events which is a function of Sun-cloud-sensor geometry and the speed of cloud propagation over the measuring site. In both the UV-A and UV-B wavelengths, significant CSIR durations of up to 30 minutes were observed. C 1997 Elsevier Science B.V.

  3. Impact of Prunus Cerasus on PGR and HAS2 in Cumulus Cells and Fertility Outcome

    PubMed Central

    Namvar Vansofla, Fatemeh; Roshangar, Leila; Montaseri, Azadeh; Soleimani Rad, Jafar

    2016-01-01

    Purpose: Cumulus cells have a critical role in normal oocyte development and fertilization. Prunus cerasus is an anthocyanin rich berry and performs strong antioxidant activity. The present study set to determine if Prunus cerasus can affect expression of HAS2 (hyaluronan synthase 2) and progesterone receptor in Cumulus cells and its consequences outcome of the in vitro fertilization. Methods: 60 female and 15 male adult mice were used for mating and IVF (in vitro fertilization). Prunus cerasus extraction was added to the diet of female mice for 30 days. Ovulation induction and oocytes collection were done as routine. The cumulus cells were dissected apart, and the expression of progesterone receptor and HAS2 was detected using RT-PCR (real-time polymerase chain reaction). Fertilization rate was evaluated by IVF. All data were analyzed using t-test. Results: Data was showed that expression of progesterone receptor and HAS2 in cumulus cells of mice that received prunus cerasus increased. Moreover, oocyte fertilization rate also increased significantly. Conclusion: Prunus cerasus as an antioxidant natural can become an important medication for improving oocyte quality and opening new opportunities for infertility treatment. It is concluded that Prunus cerasus consumption could improve fertility rate by increasing progesterone receptor and HAS2 activity in cumulus cells. PMID:27123419

  4. The fine structure of the cumulus oophorus during follicular development in sheep.

    PubMed

    Cran, D G; Hay, M F; Moor, R M

    1979-11-01

    The cumulus and membrana granulosa of non-atretic ovarian follicles from primordial up to a stage shortly before ovulation were studied by electron microscopy. The follicular cells of primordial follicles were undifferentiated and rested on a thick basal lamina. In secondary follicles the endoplasmic reticulum had proliferated forming an anastomosing network. In early antral and antral follicles (0.5--2.0 mm dia.) the ER was composed of short cisternae, the mitochondria had elongated and gap junctions were first observed. In late antral follicles (3.0--5.9 mm dia.) gap junctions were frequent. In the cumulus the glycogen was associated with electron lucent areas whereas in the granulosa it was invariably associated with membranes. In large antral follicles large membrane bound bodies were present in the basal cells of the cumulus. At early oestrus a distinctive mitochondrial morphology was noted in the granulosa but not elsewhere in the follicles. At mid oestrus numerous annular nexuses were present in the granulosa but not in the cumulus. At late oestrus numerous lipid droplets were formed in both cumulus and granulosa, the boundary with theca interna became indistinct and the basal lamina became incomplete. PMID:574800

  5. Goddard Space Flight Center Spacecraft Magnetic Test Facility Restoration Project

    NASA Technical Reports Server (NTRS)

    Vernier, Robert; Bonalksy, Todd; Slavin, James

    2004-01-01

    The Goddard Space Flight Center Spacecraft Magnetic Test Facility (SMTF) was constructed in the 1960's for the purpose of simulating geomagnetic and interplanetary magnetic field environments. The facility includes a three axis Braunbek coil system consisting of 12 loops, 4 loops on each of the three orthogonal axes; a remote Earth field sensing magnetometer and servo controller; and a remote power control and instrumentation building. The inner coils of the Braunbek system are 42-foot in diameter with a 10-foot by 10-foot opening through the outer coils to accommodate spacecraft access into the test volume. The physical size and precision of the facility are matched by only two other such facilities in the world. The facility was used extensively from the late 1960's until the early 1990's when the requirement for spacecraft level testing diminished. New NASA missions planned under the Living with a Star, Solar Terrestrial Probes, Explorer, and New Millennium Programs include precision, high-resolution magnetometers to obtain magnetic field data that is critical to fulfilling their scientific mission. It is highly likely that future Lunar and Martian exploration missions will also use precision magnetometers to conduct geophysical magnetic surveys. To ensure the success of these missions, ground-testing using a magnetic test facility such as the GSFC SMTF will be required. This paper describes the history of the facility, the future mission requirements that have renewed the need for spacecraft level magnetic testing, and the plans for restoring the facility to be capable of performing to its original design specifications.

  6. Goddard Space Flight Center Spacecraft Magnetic Test Facility Restoration Project

    NASA Technical Reports Server (NTRS)

    Vernier, Robert; Bonalosky, Todd; Slavin, James

    2004-01-01

    The Goddard Space Flight Center Spacecraft Magnetic Test Facility (SMTF) was constructed in the 1960's for the purpose of simulating geomagnetic and interplanetary magnetic field environments. The facility includes a three axis Braunbek coil system consisting of 12 loops, 4 loops on each of the three orthogonal axes; a remote Earth field sensing magnetometer and servo controller; and a remote power control and instrumentation building. The inner coils of the Braunbek system are 42-foot in diameter with a 10-foot by 10-foot opening through the outer coils to accommodate spacecraft access into the test volume. The physical size and precision of the facility are matched by only two other such facilities in the world. The facility was used extensively from the late 1960's until the early 1990's when the requirement for spacecraft level testing diminished. New NASA missions planned under the Living with a Star, Solar Terrestrial Probes, Explorer, and New Millennium Programs include precision, high-resolution magnetometers to obtain magnetic field data that is critical to fulfilling their scientific mission. It is highly likely that future Lunar and Martian exploration missions will also use precision magnetometers to conduct geophysical magnetic surveys. To ensure the success of these missions, ground testing using a magnetic test facility such as the GSFC SMTF will be required. This paper describes the history of the facility, the future mission requirements that have renewed the need for spacecraft level magnetic testing, and the plans for restoring the facility to be capable of performing to its original design specifications.

  7. Ocean Data from MODIS at the NASA Goddard DAAC

    NASA Technical Reports Server (NTRS)

    Leptoukh, Gregory G.; Wharton, Stephen (Technical Monitor)

    2000-01-01

    Terra satellite carrying the Moderate Resolution Imaging Spectroradiometer (MODIS) was successfully launched on December 18, 1999. Some of the 36 different wavelengths that MODIS samples have never before been measured from space. New ocean data products, which have not been derived on a global scale before, are made available for research to the scientific community. For example, MODIS uses a new split window in the four-micron region for the better measurement of Sea Surface Temperature (SST), and provides the unprecedented ability (683 nm band) to measure chlorophyll fluorescence. At full ocean production, more than a thousand different ocean products in three major categories (ocean color, sea surface temperature, and ocean primary production) are archived at the NASA Goddard Earth Sciences (GES) Distributed Active Archive Center (DAAC) at the rate of approx. 230GB/day. The challenge is to distribute such large volumes of data to the ocean community. It is achieved through a combination of public and restricted EOS Data Gateways, the GES DAAC Search and Order WWW interface, and an FTP site that contains samples of MODIS data. A new Search and Order WWW interface at http://acdisx.gsfc.nasa.gov/data/ developed at the GES DAAC is based on a hierarchical organization of data, will always return non-zero results. It has a very convenient geographical representation of five-minute data granule coverage for each day MODIS Data Support Team (MDST) continues the tradition of quality support at the GES DAAC for the ocean color data from the Coastal Zone Color Scanner (CZCS) and the Sea Viewing Wide Field-of-View Sensor (SeaWiFS) by providing expert assistance to users in accessing data products, information on visualization tools, documentation for data products and formats (Hierarchical Data Format-Earth Observing System (HDF-EOS)), information on the scientific content of products and metadata. Visit the MDST website at http://daac.gsfc.nasa.gov/CAMPAIGN DOCS/MODIS/index.html

  8. The Goddard High Resolution Spectrograph Scientific Support Contract

    NASA Technical Reports Server (NTRS)

    1997-01-01

    In 1988, Computer Sciences Corporation (CSC) was selected as the Goddard High Resolution Spectrograph (GHRS) Scientific Support Contractor (SSC). This was to have been a few months before the launch of NASA's first Great Observatory, the Hubble Space Telescope (HST). As one of five scientific instruments on HST, the GHRS was designed to obtain spectra in the 1050-3300 A ultraviolet wavelength region with a resolving power, lambda/Delta(lambda) , of up to 100,000 and relative photometric accuracy to 1%. It was built by Ball AeroSpace Systems Group under the guidance of the GHRS Investigation Definition Team (IDT), comprised of 16 scientists from the US and Canada. After launch, the IDT was to perform the initial instrument calibration and execute a broad scientific program during a five-year Guaranteed Time Observation (GTO) period. After a year's delay, the launch of HST occurred in April 1990, and CSC participated in the in-orbit calibration and first four years of GTO observations with the IDT. The HST primary mirror suffered from spherical aberration, which reduced the spatial and spectral resolution of Large Science Aperture (LSA) observations and decreased the throughput of the Small Science Aperture (SSA) by a factor of two. Periodic problems with the Side 1 carrousel electronics and anomalies with the low-voltage power supply finally resulted in a suspension of the use of Side 1 less than two years after launch. At the outset, the GHRS SSC task involved work in four areas: 1) to manage and operate the GHRS Data Analysis Facility (DAF); 2) to support the second Servicing Mission Observatory Verification (SMOV) program, as well as perform system engineering analysis of the GHRS as nesessary; 3) to assist the GHRS IDT with their scientific research programs, particularly the GSFC members of the team, and 4) to provide administrative and logistic support for GHRS public information and educational activities.

  9. Constraints on Cumulus Parameterization from Simulations of Observed MJO Events

    NASA Technical Reports Server (NTRS)

    Del Genio, Anthony; Wu, Jingbo; Wolf, Audrey B.; Chen, Yonghua; Yao, Mao-Sung; Kim, Daehyun

    2015-01-01

    Two recent activities offer an opportunity to test general circulation model (GCM) convection and its interaction with large-scale dynamics for observed Madden-Julian oscillation (MJO) events. This study evaluates the sensitivity of the Goddard Institute for Space Studies (GISS) GCM to entrainment, rain evaporation, downdrafts, and cold pools. Single Column Model versions that restrict weakly entraining convection produce the most realistic dependence of convection depth on column water vapor (CWV) during the Atmospheric Radiation Measurement MJO Investigation Experiment at Gan Island. Differences among models are primarily at intermediate CWV where the transition from shallow to deeper convection occurs. GCM 20-day hindcasts during the Year of Tropical Convection that best capture the shallow–deep transition also produce strong MJOs, with significant predictability compared to Tropical Rainfall Measuring Mission data. The dry anomaly east of the disturbance on hindcast day 1 is a good predictor of MJO onset and evolution. Initial CWV there is near the shallow–deep transition point, implicating premature onset of deep convection as a predictor of a poor MJO simulation. Convection weakly moistens the dry region in good MJO simulations in the first week; weakening of large-scale subsidence over this time may also affect MJO onset. Longwave radiation anomalies are weakest in the worst model version, consistent with previous analyses of cloud/moisture greenhouse enhancement as the primary MJO energy source. The authors’ results suggest that both cloud-/moisture-radiative interactions and convection–moisture sensitivity are required to produce a successful MJO simulation.

  10. Annotated Bibliography of EDGE2D Use

    SciTech Connect

    J.D. Strachan and G. Corrigan

    2005-06-24

    This annotated bibliography is intended to help EDGE2D users, and particularly new users, find existing published literature that has used EDGE2D. Our idea is that a person can find existing studies which may relate to his intended use, as well as gain ideas about other possible applications by scanning the attached tables.

  11. Staring 2-D hadamard transform spectral imager

    DOEpatents

    Gentry, Stephen M.; Wehlburg, Christine M.; Wehlburg, Joseph C.; Smith, Mark W.; Smith, Jody L.

    2006-02-07

    A staring imaging system inputs a 2D spatial image containing multi-frequency spectral information. This image is encoded in one dimension of the image with a cyclic Hadamarid S-matrix. The resulting image is detecting with a spatial 2D detector; and a computer applies a Hadamard transform to recover the encoded image.

  12. 76 FR 56797 - United States v. Cumulus Media Inc., et al.; Proposed Final Judgment and Competitive Impact...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-14

    ... largest radio broadcast companies in the United States in terms of revenue. In 2010, Cumulus reported... Complaint alleging that Cumulus Media Inc.'s proposed acquisition of Citadel Broadcasting Corporation would... Inc., 3280 Peachtree Road, NW., Atlanta, Georgia 30305, and Citadel Broadcasting Corporation,...

  13. Molecular analysis of the cumulus matrix: insights from mice with O-glycan-deficient oocytes

    PubMed Central

    Ploutarchou, Panayiota; Melo, Pedro; Day, Anthony J; Milner, Caroline M; Williams, Suzannah A

    2015-01-01

    During follicle development, oocytes secrete factors that influence the development of granulosa and cumulus cells (CCs). In response to oocyte and somatic cell signals, CCs produce extracellular matrix (ECM) molecules resulting in cumulus expansion, which is essential for ovulation, fertilisation, and is predictive of oocyte quality. The cumulus ECM is largely made up of hyaluronan (HA), TNF-stimulated gene-6 (TSG-6, also known as TNFAIP6), pentraxin-3 (PTX3), and the heavy chains (HCs) of serum-derived inter-α-inhibitor proteins. In contrast to other in vivo models where modified expansion impairs fertility, the cumulus mass of C1galt1 Mutants, which have oocyte-specific deletion of core 1-derived O-glycans, is modified without impairing fertility. In this report, we used C1galt1 Mutant (C1galt1 FF:ZP3Cre) and Control (C1galt1 FF) mice to investigate how cumulus expansion is affected by oocyte-specific deletion of core 1-derived O-glycans without adversely affecting oocyte quality. Mutant cumulus–oocyte complexes (COCs) are smaller than Controls, with fewer CCs. Interestingly, the CCs in Mutant mice are functionally normal as each cell produced normal levels of the ECM molecules HA, TSG-6, and PTX3. However, HC levels were elevated in Mutant COCs. These data reveal that oocyte glycoproteins carrying core 1-derived O-glycans have a regulatory role in COC development. In addition, our study of Controls indicates that a functional COC can form provided all essential components are present above a minimum threshold level, and thus some variation in ECM composition does not adversely affect oocyte development, ovulation or fertilisation. These data have important implications for IVF and the use of cumulus expansion as a criterion for oocyte assessment. PMID:25855670

  14. Time course of the meiotic arrest in sheep cumulus-oocyte complexes treated with roscovitine.

    PubMed

    Crocomo, Letícia Ferrari; Marques Filho, Wolff Camargo; Ackermann, Camila Louise; Paschoal, Daniela Martins; Guastali, Midyan Daroz; Dias Maziero, Rosiára Rosária; Sudano, Mateus José; Landim-Alvarenga, Fernanda da Cruz; Bicudo, Sony Dimas

    2016-04-01

    Temporary meiosis arrest with cyclin-dependent kinases inhibitors has been proposed in order to improve the quality of in vitro matured oocytes. In sheep, however, this phenomenon has been rarely investigated. Therefore, the present study aimed to evaluate the effect of different incubation times with roscovitine on nuclear maturation and cumulus cell expansion of sheep cumulus-oocyte complexes (COCs). For this, COCs were cultured for 0, 6, 12 or 20 h in basic maturation medium (Control) containing 75 μM roscovitine (Rosco). After, they were in vitro matured (IVM) for 18 h in the presence of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). At the end of each treatment, cumulus cell expansion and nuclear maturation were assessed under a stereomicroscope and by Hoechst 33342 staining, respectively. In the Control and Rosco groups, the absence of cumulus cell expansion prevailed at 0, 6, 12 and 20 h. After IVM for 18 h, total cumulus cell expansion in the Rosco treatments was dependent on the exposure time to roscovitine. A significantly high percentage of oocytes treated with roscovitine for 6 h (87%), 12 h or 20 h (65%) were arrested at the germinal vesicle (GV) stage. In contrast, 23% GVBD, 54% metaphase I (MI) and 61% MII oocytes were observed in the Control groups at 6, 12 and 20 h, respectively. In all treatments, a significant percentage of oocytes reached MII after IVM for 18 h. Therefore, roscovitine reversibly arrested the meiosis of sheep oocytes during different culture times with the maximal efficiency of meiotic inhibition reached at 6 h. In addition, reversibility of its inhibitory action on cumulus cells was exposure-time dependent. PMID:26170094

  15. The cumulus cell layer protects the bovine maturing oocyte against fatty acid-induced lipotoxicity.

    PubMed

    Lolicato, Francesca; Brouwers, Jos F; de Lest, Chris H A van; Wubbolts, Richard; Aardema, Hilde; Priore, Paola; Roelen, Bernard A J; Helms, J Bernd; Gadella, Bart M

    2015-01-01

    Mobilization of fatty acids from adipose tissue during metabolic stress increases the amount of free fatty acids in blood and follicular fluid and is associated with impaired female fertility. In a previous report, we described the effects of the three predominant fatty acids in follicular fluid (saturated palmitate and stearate and unsaturated oleate) on oocyte maturation and quality. In the current study, the effects of elevated fatty acid levels on cumulus cells were investigated. In a dose-dependent manner, the three fatty acids induced lipid storage in cumulus cells accompanied by an enhanced immune labeling of perilipin-2, a marker for lipid droplets. Lipidomic analysis confirmed incorporation of the administered fatty acids into triglyceride, resulting in a 3- to 6-fold increase of triglyceride content. In addition, palmitate selectively induced ceramide formation, which has been implicated in apoptosis. Indeed, of the three fatty acids tested, palmitate induced reactive oxygen species formation, caspase 3 activation, and mitochondria deterioration, leading to degeneration of the cumulus cell layers. This effect could be mimicked by addition of the ceramide-C2 analog and could be inhibited by the ceramide synthase inhibitor fumonisin-B1. Interfering with the intactness of the cumulus cell layers, either by mechanical force or by palmitate treatment, resulted in enhanced uptake of lipids in the oocyte and increased radical formation. Our results show that cumulus cells act as a barrier, protecting oocytes from in vitro induced lipotoxic effects. We suggest that this protective function of the cumulus cell layers is important for the developmental competence of the oocyte. The relevance of our findings for assisted reproduction technologies is discussed. PMID:25297544

  16. A Regulation of Tropical Climate by Radiative Cooling as Simulated in a Cumulus Ensemble Model

    NASA Technical Reports Server (NTRS)

    Sui, Chung-Hsiung; Lau, K.-M.; Li, X.; Chou, M.-D.; Einaudi, Franco (Technical Monitor)

    2000-01-01

    Responses of tropical atmosphere to low-boundary forcing are investigated in a 2-D cumulus ensemble model (CEM) with an imposed warm-pool and cold-pool SST contrast (deltaSST). The domain-mean vertical motion is constrained to produce heat sink and moisture source as in the observed tropical climate. In a series of experiments, the warm pool SST is specified at different values while the cold pool SST is specified at 26 C. The strength of the circulation increases with increasing deltaSST until deltaSST reaches 3.5 C, and remains unchanged as deltaSST exceeds 3.5 C. The regulation of tropical convection by zonal SST gradient is constrained by the radiative cooling over the cold pool. For deltaSST less than 3.5 C, an enhanced subsidence warming is balanced by a reduced condensation heating over the cold pool. For deltaSST greater than 3.5 C, the subsidence regime expands over the entire cold pool where no condensation heating exist so that a further enhanced subsidence warming can no longer be sustained. The above regulation mechanism is also evident in the change of energy at the top of the atmosphere (TOA) that is dominated by cloud and water vapor greenhouse effect (c (sub LW)) and G (sub clear). The change in shortwave radiation at TOA is largely cancelled between the warm pool and cold pool, likely due to the same imposed vertical motion in our experiments. For deltaSST less than 3.5 C, an increase of deltaSST is associated with a large increase in c (sub Lw) due to increased total clouds in response to enhanced SST-induced circulation. For deltaSST greater than 3.5 C, clouds over the warm pool decrease with increasing SST, and the change in c (sub LW) is much smaller. In both dSST regimes, the change in CLW is larger than the change in G(sub clear) which is slightly negative. However, in the case of uniform warming (deltaSST=0), DeltaG(sub clear), is positive, approximately 5 W per square meters per degree change of SST.

  17. Effects of aerosols and relative humidity on cumulus clouds

    NASA Astrophysics Data System (ADS)

    Fan, Jiwen; Zhang, Renyi; Li, Guohui; Tao, Wei-Kuo

    2007-07-01

    The influences of the aerosol type and concentration and relative humidity (RH) on cumulus clouds have been investigated using a two-dimensional spectral-bin cloud model. Three simulations are conducted to represent the polluted continental, clean continental, and marine aerosol types. Under the same initial dynamic and thermodynamic conditions, the maritime aerosol case results in more intensive radar reflectivity in both developing and mature stages than the continental aerosol cases, because of enhanced warm rain by collisions and ice processes by deposition growth due to larger droplet sizes and higher supersaturation, respectively. The considerable delay in convective development due to reduced droplet condensation is responsible for the longer cloud lifetime in the marine aerosol case. For the continental case, the most noticeable effects of increasing aerosol number concentrations (with 15 different initial values) are the increases of the cloud droplet number concentration and cloud water content but a decrease in the effective droplet radius. More latent heat release from increasing condensation results in stronger convection and more melting precipitation at the higher aerosol concentrations. Melting precipitation and secondary clouds primarily contribute to enhanced precipitation with increasing aerosols. The precipitation, however, decreases with increasing aerosol in the extremely high aerosol cases (over 5 × 104 cm-3) due to suppression of convection from depleted water vapor and inefficient coalescence. When the initial aerosol concentration exceeds a critical level, most of the cloud properties become less sensitive to aerosols, implying that the aerosol effect on deep convection is more pronounced in relatively clean air than in heavily polluted air. The aerosol effect on the cloud properties is strongly dependent on RH. As the surface RH increases from 40 to 70%, the cloud changes from shallow warm to deep convective types due to a significant

  18. Light field morphing using 2D features.

    PubMed

    Wang, Lifeng; Lin, Stephen; Lee, Seungyong; Guo, Baining; Shum, Heung-Yeung

    2005-01-01

    We present a 2D feature-based technique for morphing 3D objects represented by light fields. Existing light field morphing methods require the user to specify corresponding 3D feature elements to guide morph computation. Since slight errors in 3D specification can lead to significant morphing artifacts, we propose a scheme based on 2D feature elements that is less sensitive to imprecise marking of features. First, 2D features are specified by the user in a number of key views in the source and target light fields. Then the two light fields are warped view by view as guided by the corresponding 2D features. Finally, the two warped light fields are blended together to yield the desired light field morph. Two key issues in light field morphing are feature specification and warping of light field rays. For feature specification, we introduce a user interface for delineating 2D features in key views of a light field, which are automatically interpolated to other views. For ray warping, we describe a 2D technique that accounts for visibility changes and present a comparison to the ideal morphing of light fields. Light field morphing based on 2D features makes it simple to incorporate previous image morphing techniques such as nonuniform blending, as well as to morph between an image and a light field. PMID:15631126

  19. 2D materials for nanophotonic devices

    NASA Astrophysics Data System (ADS)

    Xu, Renjing; Yang, Jiong; Zhang, Shuang; Pei, Jiajie; Lu, Yuerui

    2015-12-01

    Two-dimensional (2D) materials have become very important building blocks for electronic, photonic, and phononic devices. The 2D material family has four key members, including the metallic graphene, transition metal dichalcogenide (TMD) layered semiconductors, semiconducting black phosphorous, and the insulating h-BN. Owing to the strong quantum confinements and defect-free surfaces, these atomically thin layers have offered us perfect platforms to investigate the interactions among photons, electrons and phonons. The unique interactions in these 2D materials are very important for both scientific research and application engineering. In this talk, I would like to briefly summarize and highlight the key findings, opportunities and challenges in this field. Next, I will introduce/highlight our recent achievements. We demonstrated atomically thin micro-lens and gratings using 2D MoS2, which is the thinnest optical component around the world. These devices are based on our discovery that the elastic light-matter interactions in highindex 2D materials is very strong. Also, I would like to introduce a new two-dimensional material phosphorene. Phosphorene has strongly anisotropic optical response, which creates 1D excitons in a 2D system. The strong confinement in phosphorene also enables the ultra-high trion (charged exciton) binding energies, which have been successfully measured in our experiments. Finally, I will briefly talk about the potential applications of 2D materials in energy harvesting.

  20. Inertial solvation in femtosecond 2D spectra

    NASA Astrophysics Data System (ADS)

    Hybl, John; Albrecht Ferro, Allison; Farrow, Darcie; Jonas, David

    2001-03-01

    We have used 2D Fourier transform spectroscopy to investigate polar solvation. 2D spectroscopy can reveal molecular lineshapes beneath ensemble averaged spectra and freeze molecular motions to give an undistorted picture of the microscopic dynamics of polar solvation. The transition from "inhomogeneous" to "homogeneous" 2D spectra is governed by both vibrational relaxation and solvent motion. Therefore, the time dependence of the 2D spectrum directly reflects the total response of the solvent-solute system. IR144, a cyanine dye with a dipole moment change upon electronic excitation, was used to probe inertial solvation in methanol and propylene carbonate. Since the static Stokes' shift of IR144 in each of these solvents is similar, differences in the 2D spectra result from solvation dynamics. Initial results indicate that the larger propylene carbonate responds more slowly than methanol, but appear to be inconsistent with rotational estimates of the inertial response. To disentangle intra-molecular vibrations from solvent motion, the 2D spectra of IR144 will be compared to the time-dependent 2D spectra of the structurally related nonpolar cyanine dye HDITCP.

  1. Internal Photoemission Spectroscopy of 2-D Materials

    NASA Astrophysics Data System (ADS)

    Nguyen, Nhan; Li, Mingda; Vishwanath, Suresh; Yan, Rusen; Xiao, Shudong; Xing, Huili; Cheng, Guangjun; Hight Walker, Angela; Zhang, Qin

    Recent research has shown the great benefits of using 2-D materials in the tunnel field-effect transistor (TFET), which is considered a promising candidate for the beyond-CMOS technology. The on-state current of TFET can be enhanced by engineering the band alignment of different 2D-2D or 2D-3D heterostructures. Here we present the internal photoemission spectroscopy (IPE) approach to determine the band alignments of various 2-D materials, in particular SnSe2 and WSe2, which have been proposed for new TFET designs. The metal-oxide-2-D semiconductor test structures are fabricated and characterized by IPE, where the band offsets from the 2-D semiconductor to the oxide conduction band minimum are determined by the threshold of the cube root of IPE yields as a function of photon energy. In particular, we find that SnSe2 has a larger electron affinity than most semiconductors and can be combined with other semiconductors to form near broken-gap heterojunctions with low barrier heights which can produce a higher on-state current. The details of data analysis of IPE and the results from Raman spectroscopy and spectroscopic ellipsometry measurements will also be presented and discussed.

  2. The 1995 Goddard Conference on Space Applications of Artificial Intelligence and Emerging Information Technologies

    NASA Technical Reports Server (NTRS)

    Hostetter, Carl F. (Editor)

    1995-01-01

    This publication comprises the papers presented at the 1995 Goddard Conference on Space Applications of Artificial Intelligence and Emerging Information Technologies held at the NASA/Goddard Space Flight Center, Greenbelt, Maryland, on May 9-11, 1995. The purpose of this annual conference is to provide a forum in which current research and development directed at space applications of artificial intelligence can be presented and discussed.

  3. Payload test philosophy. [implications of STS development at Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Arman, A.

    1979-01-01

    The implications of STS development for payload testing at the Goddard Space Flight Center are reviewed. The biggest impact of STS may be that instead of testing the entire payload, most of the testing may have to be limited to the subsystem or subassembly level. Particular consideration is given to the Goddard protoflight concept in which the test is geared to the design qualification levels, the test durations being those that are expected during the actual launch sequence.

  4. Modeling Ni-Cd performance. Planned alterations to the Goddard battery model

    NASA Technical Reports Server (NTRS)

    Jagielski, J. M.

    1986-01-01

    The Goddard Space Flight Center (GSFC) currently has a preliminary computer model to simulate a Nickel Cadmium (Ni-Cd) performance. The basic methodology of the model was described in the paper entitled Fundamental Algorithms of the Goddard Battery Model. At present, the model is undergoing alterations to increase its efficiency, accuracy, and generality. A review of the present battery model is given, and the planned charges of the model are described.

  5. New data and capabilities in the NASA Goddard Giovanni system

    NASA Astrophysics Data System (ADS)

    Rui, H.; Farley, J.; Leptoukh, G.; Berrick, S. W.

    2007-12-01

    Giovanni, the GES-DISC Interactive Online Visualization ANd aNalysis Infrastructure, is the underlying infrastructure for a growing family of Web interfaces that allows users to analyze gridded and swath data interactively online without having to download any data. Giovanni is a simple but powerful tool for researchers to explore and analyze data without having to deal with original data format, volume, and complexity. Since 2002, Giovanni has served many users worldwide with TRMM and MODIS data visualization and analysis. With increasing size and complexity of Earth and Space Science data holdings and growing demands for better, faster, and less costly tools for data exploration, visualization and analysis, Giovanni has been extended to serve CALIPSO, CloudSat, SeaWiFS, TOMS, AIRS, OMI, MLS-Aura, HIRDLS, and HALOE data to the Atmospheric Composition, Aerosol, Air Quality, and other research communities. To further improve Giovanni extendibility, accessibility, and performance, Giovanni version 3 (G3) has been developed and is currently in operation at the Goddard Earth Sciences Data and Information Services Center (GES DISC). In addition to the existing Giovanni instances, several new G3 instances have been released, including (1) A-Train Data Depot that is capable to allow access to, visualize, analyze and correlate distributed atmospheric measurements from A-Train instruments; (2) NEESPI, a multi-sensor multi-disciplinary instance dedicated to the studies of the environment of the Northern Eurasia; (3) Data Fusion, a prototype Giovanni instance that demonstrates the G3 capability for fusing Earth Science data from multiple sensors. Giovanni capabilities have also been extended to include direct access via WMS protocol, and to provide output in various popular formats, like KML for Google Earth. With much progress in data visualization, data analysis, and easy-to-use toolkits, G3 has simplified and strengthened its capabilities of providing closer links between

  6. Gravitational model improvement at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Marsh, J. G.; Lerch, F. J.; Putney, B. H.; Felsentreger, T. L.; Sanchez, B. V.; Smith, D. E.; Klosko, S. M.; Pavlis, E. C.; Robbins, J. W.; Williamson, R. G.

    1989-01-01

    Major new computations of terrestrial gravitational field models were performed by the Geodynamics Branch of Goddard Space Flight Center (GSFC). This development has incorporated the present state of the art results in satellite geodesy and have relied upon a more consistent set of reference constants than was heretofore utilized in GSFC's GEM models. The solutions are complete in spherical harmonic coefficients out to degree 50 for the gravity field parameters. These models include adjustment for a subset of 66 ocean tidal coefficients for the long wavelength components of 12 major ocean tides. This tidal adjustment was made in the presence of 550 other fixed ocean tidal terms representing 32 major and minor ocean tides and the Wahr frequency dependent solid earth tidal model. In addition 5-day averaged values for Earth rotation and polar motion were derived for the time period of 1980 onward. Two types of models were computed. These are satellite only models relying exclusively on tracking data and combination models which have incorporated satellite altimetry and surface gravity data. The satellite observational data base consists of over 1100 orbital arcs of data on 31 satellites. A large percentage of these observations were provided by third generation laser stations (less than 5 cm). A calibration of the model accuracy of the GEM-T2 satellite only solution indicated that it was a significant improvement over previous models based solely upon tracking data. The rms geoid error for this field is 110 cm to degree and order 36. This is a major advancement over GEM-T1 whose errors were estimated to be 160 cm. An error propagation using the covariances of the GEM-T2 model for the TOPEX radial orbit component indicates that the rms radial errors are expected to be 12 cm. The combination solution, PGS-3337, is a preliminary effort leading to the development of GEM-T3. PGS-3337 has incorporated global sets of surface gravity data and the Seasat altimetry to produce a

  7. Update on the Fabrication and Performance of 2-D Arrays of Superconducting Magnesium Diboride (MgB2) Thermal Detectors for Outer-Planets Exploration

    NASA Technical Reports Server (NTRS)

    Lakew, Brook; Aslam, S.

    2011-01-01

    Detectors with better performance than the current thermopile detectors that operate at room temperature will be needed at the focal plane of far-infrared instruments on future planetary exploration missions. We will present an update on recent results from the 2-D array of MgB2 thermal detectors being currently developed at NASA Goddard. Noise and sensitivity results will be presented and compared to thermal detectors currently in use on planetary missions.

  8. Update on the fabrication and performance of 2-D arrays of superconducting Magnesium Diboride (MgB2) thermal detectors for outer-planets exploration.

    NASA Astrophysics Data System (ADS)

    Lakew, B.; Aslam, S.

    2011-10-01

    Detectors with better performance than the current thermopile detectors that operate at room temperature will be needed at the focal plane of far-infrared instruments on future planetary exploration missions. We will present an update on recent results from the 2-D array of MgB2 thermal detectors being currently developed at NASA Goddard. Noise and sensitivity results will be presented and compared to thermal detectors currently in use on planetary missions.

  9. Brittle damage models in DYNA2D

    SciTech Connect

    Faux, D.R.

    1997-09-01

    DYNA2D is an explicit Lagrangian finite element code used to model dynamic events where stress wave interactions influence the overall response of the system. DYNA2D is often used to model penetration problems involving ductile-to-ductile impacts; however, with the advent of the use of ceramics in the armor-anti-armor community and the need to model damage to laser optics components, good brittle damage models are now needed in DYNA2D. This report will detail the implementation of four brittle damage models in DYNA2D, three scalar damage models and one tensor damage model. These new brittle damage models are then used to predict experimental results from three distinctly different glass damage problems.

  10. Matrix models of 2d gravity

    SciTech Connect

    Ginsparg, P.

    1991-01-01

    These are introductory lectures for a general audience that give an overview of the subject of matrix models and their application to random surfaces, 2d gravity, and string theory. They are intentionally 1.5 years out of date.

  11. Matrix models of 2d gravity

    SciTech Connect

    Ginsparg, P.

    1991-12-31

    These are introductory lectures for a general audience that give an overview of the subject of matrix models and their application to random surfaces, 2d gravity, and string theory. They are intentionally 1.5 years out of date.

  12. 2D electronic materials for army applications

    NASA Astrophysics Data System (ADS)

    O'Regan, Terrance; Perconti, Philip

    2015-05-01

    The record electronic properties achieved in monolayer graphene and related 2D materials such as molybdenum disulfide and hexagonal boron nitride show promise for revolutionary high-speed and low-power electronic devices. Heterogeneous 2D-stacked materials may create enabling technology for future communication and computation applications to meet soldier requirements. For instance, transparent, flexible and even wearable systems may become feasible. With soldier and squad level electronic power demands increasing, the Army is committed to developing and harnessing graphene-like 2D materials for compact low size-weight-and-power-cost (SWAP-C) systems. This paper will review developments in 2D electronic materials at the Army Research Laboratory over the last five years and discuss directions for future army applications.

  13. 2-d Finite Element Code Postprocessor

    1996-07-15

    ORION is an interactive program that serves as a postprocessor for the analysis programs NIKE2D, DYNA2D, TOPAZ2D, and CHEMICAL TOPAZ2D. ORION reads binary plot files generated by the two-dimensional finite element codes currently used by the Methods Development Group at LLNL. Contour and color fringe plots of a large number of quantities may be displayed on meshes consisting of triangular and quadrilateral elements. ORION can compute strain measures, interface pressures along slide lines, reaction forcesmore » along constrained boundaries, and momentum. ORION has been applied to study the response of two-dimensional solids and structures undergoing finite deformations under a wide variety of large deformation transient dynamic and static problems and heat transfer analyses.« less

  14. Chemical Approaches to 2D Materials.

    PubMed

    Samorì, Paolo; Palermo, Vincenzo; Feng, Xinliang

    2016-08-01

    Chemistry plays an ever-increasing role in the production, functionalization, processing and applications of graphene and other 2D materials. This special issue highlights a selection of enlightening chemical approaches to 2D materials, which nicely reflect the breadth of the field and convey the excitement of the individuals involved in it, who are trying to translate graphene and related materials from the laboratory into a real, high-impact technology. PMID:27478083

  15. Extended 2D generalized dilaton gravity theories

    NASA Astrophysics Data System (ADS)

    de Mello, R. O.

    2008-09-01

    We show that an anomaly-free description of matter in (1+1) dimensions requires a deformation of the 2D relativity principle, which introduces a non-trivial centre in the 2D Poincaré algebra. Then we work out the reduced phase space of the anomaly-free 2D relativistic particle, in order to show that it lives in a noncommutative 2D Minkowski space. Moreover, we build a Gaussian wave packet to show that a Planck length is well defined in two dimensions. In order to provide a gravitational interpretation for this noncommutativity, we propose to extend the usual 2D generalized dilaton gravity models by a specific Maxwell component, which guages the extra symmetry associated with the centre of the 2D Poincaré algebra. In addition, we show that this extension is a high energy correction to the unextended dilaton theories that can affect the topology of spacetime. Further, we couple a test particle to the general extended dilaton models with the purpose of showing that they predict a noncommutativity in curved spacetime, which is locally described by a Moyal star product in the low energy limit. We also conjecture a probable generalization of this result, which provides strong evidence that the noncommutativity is described by a certain star product which is not of the Moyal type at high energies. Finally, we prove that the extended dilaton theories can be formulated as Poisson Sigma models based on a nonlinear deformation of the extended Poincaré algebra.

  16. Radar Reflectivity Simulated by a 2-D Spectra Bin Model: Sensitivity of Cloud-aerosol Interaction

    NASA Technical Reports Server (NTRS)

    Li, Kiaowen; Tao, Wei-Kuo; Khain, Alexander; Simpson, Joanne; Johnson, Daniel

    2003-01-01

    The Goddard Cumulus Ensemble (GCE) model with bin spectra microphysics is used to simulate mesoscale convective systems.The model uses explicit bins to represent size spectra of cloud nuclei, water drops, ice crystals, snow and graupel. Each hydrometeorite category is described by 33 mass bins. The simulations provide a unique data set of simulated raindrop size distribution in a realistic dynamic frame. Calculations of radar parameters using simulated drop size distribution serve as an evaluation of numerical model performance. In addition, the GCE bin spectra modes is a very useful tool to study uncertainties related to radar observations; all the environmental parameters are precisely known. In this presentation, we concentrate on the discussion of Z-R (ZDR-R) relation in the simulated systems. Due to computational limitations, the spectra bin model has been run in two dimensions with 31 stretched vertical layers and 1026 horizontal grid points (1 km resolution). Two different cases, one in midlatitude continent, the other in tropical ocean, have been simulated. The continental case is a strong convection which lasted for two hours. The oceanic case is a persistent system with more than 10 hours' life span. It is shown that the simulated Z-R (ZDR-R) relations generally agree with observations using radar and rain gauge data. The spatial and temporal variations of Z-R relation in different locations are also analyzed. Impact of aerosols on cloud formation and raindrop size distribution was studied. Both clean (low CCN) and dirty (high CCN) cases are simulated. The Z-R relation is shown to vary considerable in the initial CCN concentrations.

  17. Effect of Acrylamide on Oocyte Nuclear Maturation and Cumulus Cells Apoptosis in Mouse In Vitro

    PubMed Central

    Liu, Shuzhen; Jiang, Ligang; Zhong, Tao; Kong, Shuhui; Zheng, Rongbin; Kong, Fengyun; Zhang, Cong; Zhang, Lei; An, Liguo

    2015-01-01

    Acrylamide (ACR) is a chemical compound with severe neurotoxicity, genotoxicity, carcinogenicity and reproductive toxicity. Recent studies showed that ACR impairs the function of reproductive organs, e.g., epididymis and testes. In vitro maturation of mouse oocyte is a sensitive assay to identify potential chemical hazard to female fertility. The aim of this study was to evaluate the adverse effects of ACR on the nuclear maturation and cumulus cells apoptosis of mouse oocytes in vitro. Cumulus–oocyte complexes were incubated in a maturation medium containing 0, 5, 10 and 20 μM of ACR. Chromosome alignment and spindle morphology of oocytes was determined by immunofluorescence and confocal microscopy. Our results showed that oocytes exposed to different doses of ACR in vitro were associated with a significant decrease of oocyte maturation, significant increase of chromosome misalignment rate, occurrence of abnormal spindle configurations, and the inhibition of oocyte parthenogenetic activation. Furthermore, apoptosis of cumulus cells was determined by TUNEL and CASPASE-3 assay. Results showed that apoptosis in cumulus cells was enhanced and the expression of CASPASE-3 was increased after cumulus–oocyte complexes were exposed to ACR. Therefore, ACR may affect the nuclear maturation of oocytes via the apoptosis of cumulus cells in vitro. PMID:26275143

  18. Mouse Oocyte Control of Granulosa Cell Development and Function: Paracrine Regulation of Cumulus Cell Metabolism

    PubMed Central

    Su, You-Qiang; Sugiura, Koji; Eppig, John J.

    2009-01-01

    Bi-directional communication between oocytes and the companion granulosa cells is essential for the development and functions of both compartments. Oocytes are deficient in their ability to transport certain amino acids and in carrying out glycolysis and cholesterol biosynthesis, and require that cumulus cells provide them with the specific amino acids and the products in these metabolic pathways. Oocytes control metabolic activities in cumulus cells by promoting the expression of genes in cumulus cells encoding specific amino acid transporters and enzymes essential for the oocyte-deficient metabolic processes. Hence, oocytes outsource metabolic functions to cumulus cells to compensate for oocyte metabolic deficiencies. Oocyte control of granulosa cell metabolism may also participate in regulating the rate of follicular development in coordination with endocrine, paracrine and autocrine signals. Oocytes influence granulosa cell development mainly by secretion of paracrine factors although juxtacrine signals probably also participate. Key oocyte-derived paracine factors include growth differentiation factor 9 (GDF9), bone morphogenetic protein 15 (BMP15) 15, and fibroblast growth factor 8B (FGF8B). PMID:19197803

  19. Effects of cumulus parameterizations on predictions of summer flood in the Central United States

    NASA Astrophysics Data System (ADS)

    Qiao, Fengxue; Liang, Xin-Zhong

    2015-08-01

    This study comprehensively evaluates the effects of twelve cumulus parameterization (CUP) schemes on simulations of 1993 and 2008 Central US summer floods using the regional climate-weather research and forecasting model. The CUP schemes have distinct skills in predicting the summer mean pattern, daily rainfall frequency and precipitation diurnal cycle. Most CUP schemes largely underestimate the magnitude of Central US floods, but three schemes including the ensemble cumulus parameterization (ECP), the Grell-3 ensemble cumulus parameterization (G3) and Zhang-McFarlane-Liang cumulus parameterization (ZML) show clear advantages over others in reproducing both floods location and amount. In particular, the ECP scheme with the moisture convergence closure over land and cloud-base vertical velocity closure over oceans not only reduces the wet biases in the G3 and ZML schemes along the US coastal oceans, but also accurately reproduces the Central US daily precipitation variation and frequency distribution. The Grell (GR) scheme shows superiority in reproducing the Central US nocturnal rainfall maxima, but others generally fail. This advantage of GR scheme is primarily due to its closure assumption in which the convection is determined by the tendency of large-scale instability. Future study will attempt to incorporate the large-scale tendency assumption as a trigger function in the ECP scheme to improve its prediction of Central US rainfall diurnal cycle.

  20. Extensive effects of in vitro oocyte maturation on rhesus monkey cumulus cell transcriptome

    PubMed Central

    Lee, Young S.; VandeVoort, Catherine A.; Gaughan, John P.; Midic, Uros; Obradovic, Zoran

    2011-01-01

    The elaboration of a quality oocyte is integrally linked to the correct developmental progression of cumulus cell phenotype. In humans and nonhuman primates, oocyte quality is diminished with in vitro maturation. To determine the changes in gene expression in rhesus monkey cumulus cells (CC) that occur during the final day prior to oocyte maturation and how these changes differ between in vitro (IVM) and in vivo maturation (VVM), we completed a detailed comparison of transcriptomes using the Affymetrix gene array. We observed a large number of genes differing in expression when comparing IVM-CC and VVM-CC directly but a much larger number of differences when comparing the transitions from the prematuration to the post-IVM and post-VVM states. We observed a truncation or delay in the normal pattern of gene regulation but also remarkable compensatory changes in gene expression during IVM. Among the genes affected by IVM are those that contribute to productive cell-cell interactions between cumulus cell and oocyte and between cumulus cells. Numerous genes involved in lipid metabolism are incorrectly regulated during IVM, and the synthesis of sex hormones appears not to be suppressed during IVM. We identified a panel of 24 marker genes, the expression of which should provide the foundation for understanding how IVM can be improved for monitoring IVM conditions and for diagnosing oocyte quality. PMID:21487073

  1. Regulation of Oocyte and Cumulus Cell Interactions by Intermedin/Adrenomedullin 2*

    PubMed Central

    Chang, Chia Lin; Wang, Hsin-Shih; Soong, Yung-Kuei; Huang, Shang Yu; Pai, Shun Yuan; Hsu, Sheau Yu Teddy

    2011-01-01

    Ovarian folliculogenesis has been studied as a model of hormonal regulation of development and differentiation, cell death, and cell-cell communication. In addition to gonadotropins from the pituitary and follicular paracrine factors, oocyte secreted factors have been shown to play critical roles in the regulation of follicular cell functions. Except for the well characterized BMP family proteins, including GDF9 and BMP15, oocytes are known to secrete oocyte secreted factors that are important for the regulation of cumulus cell survival and the maintenance of tertiary structure of cumulus cell-enclosed oocyte complexes (COCs). Based on genomic screening and studies of COCs cultured in vitro, we showed that intermedin (IMD)/adrenomedullin 2 (ADM2) is a novel oocyte-derived ligand important for the regulation of cell interactions in COCs that functions, in part, by suppressing cumulus cell apoptosis. Consistently, we showed that suppression of IMD/ADM2 signaling in growing rat ovaries in vivo leads to oocyte atresia and aberrant cell cycle progression in follicular cells. Together, our studies indicated that mammalian oocytes deploy a G protein-coupled receptor ligand to coordinate normal interactions of oocytes and cumulus cells and provided a better understanding of how the tertiary structure of a COC is maintained as follicles undergo exponential growth during the late stages of folliculogenesis. PMID:22009752

  2. Effects of Mitochondrial Uncoupling Protein 2 Inhibition by Genipin in Human Cumulus Cells

    PubMed Central

    Ge, Hongshan; Zhang, Fan; Shan, Dan; Chen, Hua; Wang, Xiaona; Ling, Chao; Xi, HaiTao; Huang, Jianying; Zhu, ChunFang; Lv, Jeiqiang

    2015-01-01

    UCP2 plays a physiological role by regulating mitochondrial biogenesis, maintaining energy balance, ROS elimination, and regulating cellular autophagy in numerous tissues. But the exact roles of UCP2 in cumulus cells are still not clear. Genipin, a special UCP2 inhibitor, was added into the cultural medium to explore the roles of UCP2 in human cumulus cells. There were no significant differences in ATP and mitochondrial membrane potential levels in cumulus cells from UCP2 inhibiting groups as compared with the control. The levels of ROS and Mn-SOD were markedly elevated after UCP2 inhibited Genipin. However, the ratio of reduced GSH to GSSG significantly declined after treatment with Genipin. UCP2 inhibition by Genipin also resulted in obvious increase in the active caspase-3, which accompanied the decline of caspase-3 mRNA. The level of progesterone in culture medium declined obviously after Genipin treatment. But there was no significant difference in estradiol concentrations. This study indicated that UCP2 is expressed in human cumulus cells and plays important roles on mediate ROS production, apoptotic process, and steroidogenesis, suggesting UCP2 may be involved in regulation of follicle development and oocyte maturation and quality. PMID:26356408

  3. Expression and functional activity of PACAP and its receptors on cumulus cells: effects on oocyte maturation.

    PubMed

    Barberi, Marzia; Di Paolo, Virginia; Latini, Stefania; Guglielmo, Maria Cristina; Cecconi, Sandra; Canipari, Rita

    2013-08-15

    Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor PAC1-R (PACAP type 1 receptor) are transiently expressed in granulosa cells (GCs) of mouse preovulatory follicles and affect several parameters associated with the ovulatory process. We investigated the expression of PACAP and its receptors in cumulus cells (CCs) after the LH surge and their role on cumulus expansion/apoptosis and oocyte maturation. PACAP and PAC1-R expression increased in CCs isolated at different times after treatment with human chorionic gonadotropin (hCG). Moreover, PACAP was able to reverse the inhibition of oocyte meiotic maturation caused by hypoxantine in cumulus cell-oocyte complexes (COCs) and efficiently promoted male pronuclear formation after fertilisation. PACAP was also able to induce cumulus expansion and prevent CC apoptosis. Our results demonstrated the induction of PACAP and its receptors in CCs by LH and EGF, suggesting that PACAP may play a significant role in the complex interactions of gonadotropin and growth factors during ovulation and fertilisation. PMID:23684890

  4. Bidirectional communication between cumulus cells and the oocyte: Old hands and new players?

    PubMed

    Russell, Darryl L; Gilchrist, Robert B; Brown, Hannah M; Thompson, Jeremy G

    2016-07-01

    Cumulus cell-oocyte communication is an essential feature of mammalian reproduction. Established mechanisms involve the bidirectional transfer of ions and small molecules through gap junctions that fundamentally regulate the process of oocyte maturation. Also, well established is the paracrine signaling from the oocyte to the cumulus, which regulates much of the flow of ions and molecules to the oocyte and orchestrates many of the associated local signaling events around ovulation, which is the key to establishing oocyte competence to sustain early embryo development. Less well-characterized and new potential players include exosomal transfer of noncoding RNAs from cumulus to oocytes and the recent observations of the presence of hemoglobin in oocytes and cumulus cells. The impact of these new communication pathways is either poorly defined or even unknown. Finally, signaling between the two cell types most likely continues after ovulation and even fertilization; however, this too is largely undefined but may play roles in substrate transport, sperm chemotaxis and "trapping", and potential signaling to the rest of the reproductive tract. PMID:27160446

  5. Numerical Simulation of Tropical Cumulus Clouds and Their Interaction with the Subcloud Layer

    NASA Astrophysics Data System (ADS)

    Krueger, Steven Keith

    A two-dimensional numerical model suitable for simulating an ensemble of cumulus clouds has been developed. The model is similar to one developed by Soong and Ogura (1980), but has greater emphasis on turbulent processes. In the model, cloud-scale dynamics are coupled with a third-moment turbulence closure model. A turbulence -scale condensation scheme is used to parameterize the cloud water mixing ratio. The computional domain is 30 km long and 15 km high. The horizontal grid size is 1 km, while the vertical grid size ranges from 100 m in the lowest layer to about 1 km in the uppermost. The cyclic boundary condition was used at the lateral boundaries. Two simulations were performed: one with upward large-scale vertical velocity (the disturbed case), and one without any (the undisturbed case), but otherwise identical. Deep cumulus clouds formed in the disturbed case, but only shallow clouds formed in the undisturbed case. I analyzed the response of the cumulus clouds to the large-scale "forcing" using the cloud work function (Arakawa and Schubert, 1974). In the Arakawa-Schubert cumulus parameterization, quasi-equilibrium of the cloud work function is assumed for time scales characteristic of large-scale disturbances. For steady large-scale forcing, the computed cloud work functions are approximately steady on time scales of a cloud life-cycle. Heat and moisture budgets computed from the simulations show that the "disturbed" subcloud layer (SCL) is strongly affected by cumulus circulations and rain evaporation. Both cumulus updrafts and downdrafts are important in the SCL sensible and latent heat fluxes. The strongest drafts contributed most to the SCL fluxes, but covered only a small fraction of the area. In the disturbed case, downdrafts were driven by rain water "loading" above the SCL; only within the SCL were they ever negatively buoyant. These negatively buoyant downdrafts created gust fronts and cool outflow regions. Some downdrafts in the SCL were warm, but

  6. Intel Xeon Phi accelerated Weather Research and Forecasting (WRF) Goddard microphysics scheme

    NASA Astrophysics Data System (ADS)

    Mielikainen, J.; Huang, B.; Huang, A. H.-L.

    2014-12-01

    The Weather Research and Forecasting (WRF) model is a numerical weather prediction system designed to serve both atmospheric research and operational forecasting needs. The WRF development is a done in collaboration around the globe. Furthermore, the WRF is used by academic atmospheric scientists, weather forecasters at the operational centers and so on. The WRF contains several physics components. The most time consuming one is the microphysics. One microphysics scheme is the Goddard cloud microphysics scheme. It is a sophisticated cloud microphysics scheme in the Weather Research and Forecasting (WRF) model. The Goddard microphysics scheme is very suitable for massively parallel computation as there are no interactions among horizontal grid points. Compared to the earlier microphysics schemes, the Goddard scheme incorporates a large number of improvements. Thus, we have optimized the Goddard scheme code. In this paper, we present our results of optimizing the Goddard microphysics scheme on Intel Many Integrated Core Architecture (MIC) hardware. The Intel Xeon Phi coprocessor is the first product based on Intel MIC architecture, and it consists of up to 61 cores connected by a high performance on-die bidirectional interconnect. The Intel MIC is capable of executing a full operating system and entire programs rather than just kernels as the GPU does. The MIC coprocessor supports all important Intel development tools. Thus, the development environment is one familiar to a vast number of CPU developers. Although, getting a maximum performance out of MICs will require using some novel optimization techniques. Those optimization techniques are discussed in this paper. The results show that the optimizations improved performance of Goddard microphysics scheme on Xeon Phi 7120P by a factor of 4.7×. In addition, the optimizations reduced the Goddard microphysics scheme's share of the total WRF processing time from 20.0 to 7.5%. Furthermore, the same optimizations

  7. Characterization of FSH signalling networks in bovine cumulus cells: a perspective on oocyte competence acquisition.

    PubMed

    Khan, D R; Guillemette, C; Sirard, M A; Richard, F J

    2015-09-01

    Understanding the mechanisms regulating oocyte developmental competence is essential to enhance the clinical efficiency of assisted reproduction. FSH orchestrates the acquisition of oocyte competence, both in vivo and in vitro. Multiple pathways are implicated in FSH signalling; however, their precise coordination remains unresolved. A robust system to investigate FSH signalling is oocyte in vitro maturation (IVM) and we have previously demonstrated better bovine embryo development after FSH addition for the first 6 h during IVM. Using this model, we investigated FSH signalling in cumulus through transcriptomic and pharmacological tools. We demonstrate modulation of cumulus transcriptome by FSH mainly through protein kinase A (PKA) and epidermal growth factor (EGF) pathways. Differentially expressed transcripts were implicated in cumulus expansion, steroidogenesis, cell metabolism and oocyte competence. FSH required rouse-sarcoma oncogene (SRC) for EGF receptor transactivation. PKA and EGF pathway crosstalk was investigated using extracellular signal-regulated kinases (ERK1/2) phosphorylation as the functional end-point. FSH enhanced ERK1/2 activation by the EGF pathway with a simultaneous diminution through PKA. More specifically, FSH increased dual specific phosphatase (DUSP1) transcripts via PKA although DUSP1 protein did not change since EGF was required to prevent degradation. Our findings implicate FSH in PKA and EGF pathway activation, which interact to maintain appropriate levels of ERK1/2 phosphorylation and eventually cumulus expansion, metabolism and steroidogenesis. Moreover, considering the implication of the EGF pathway in GDF9 and BMP15 actions, our findings suggest that FSH may have a role in modulation of the cumulus response to oocyte-secreted factors. This information has implications for improvement of IVM and hence oocyte developmental competence. PMID:26113519

  8. Estrogen Promotes the Development of Mouse Cumulus Cells in Coordination with Oocyte-Derived GDF9 and BMP15

    PubMed Central

    Sugiura, Koji; Su, You-Qiang; Li, Qinglei; Wigglesworth, Karen; Matzuk, Martin M.; Eppig, John J.

    2010-01-01

    The differentiation and function of cumulus cells depend upon oocyte-derived paracrine factors, but studies on the estrogen receptor knockout mice suggested that estrogen also participates in these processes. This study investigates the possible coordination of estrogen and oocytes in the development and function of cumulus cells using cumulus expansion and the expression of transcripts required for expansion as functional endpoints. Preantral granulosa cell-oocyte complexes developed in vitro with 17β-estradiol (E2) exhibited increased levels of cumulus expansion and Has2 transcripts, encoding hyaluronan synthase 2, compared with those developed without E2. Moreover, cumulus cell-oocyte complexes (COCs) isolated from antral follicles and maintained in culture without E2 exhibited reduced cumulus expansion and Has2 mRNA levels compared with freshly isolated COCs. Exogenous E2, provided during the maintenance culture, alleviated these deficiencies. However, when oocytes were removed from COCs, E2 supplementation did not maintain competence to undergo expansion; the presence in culture of either fully grown oocytes or recombinant growth differentiation factor 9 (GDF9) was required. Recombinant bone morphogenetic protein 15, but not fibroblast growth factor 8, augmented the GDF9 effect. Oocytes or GDF9 suppressed cumulus cell levels of Nrip1 transcripts encoding nuclear receptor-interacting protein 1, a potential inhibitor of estrogen receptor signals. Therefore, E2 and oocyte-derived paracrine factors GDF9 and bone morphogenetic protein 15 coordinate to promote the development of cumulus cells and maintain their competence to undergo expansion. Furthermore, suppression of Nrip1 expression in cumulus cells by oocyte may be one mechanism mediating cross talk between oocyte and E2 signals that promotes follicular development. PMID:21047911

  9. Optical modulators with 2D layered materials

    NASA Astrophysics Data System (ADS)

    Sun, Zhipei; Martinez, Amos; Wang, Feng

    2016-04-01

    Light modulation is an essential operation in photonics and optoelectronics. With existing and emerging technologies increasingly demanding compact, efficient, fast and broadband optical modulators, high-performance light modulation solutions are becoming indispensable. The recent realization that 2D layered materials could modulate light with superior performance has prompted intense research and significant advances, paving the way for realistic applications. In this Review, we cover the state of the art of optical modulators based on 2D materials, including graphene, transition metal dichalcogenides and black phosphorus. We discuss recent advances employing hybrid structures, such as 2D heterostructures, plasmonic structures, and silicon and fibre integrated structures. We also take a look at the future perspectives and discuss the potential of yet relatively unexplored mechanisms, such as magneto-optic and acousto-optic modulation.

  10. Large Area Synthesis of 2D Materials

    NASA Astrophysics Data System (ADS)

    Vogel, Eric

    Transition metal dichalcogenides (TMDs) have generated significant interest for numerous applications including sensors, flexible electronics, heterostructures and optoelectronics due to their interesting, thickness-dependent properties. Despite recent progress, the synthesis of high-quality and highly uniform TMDs on a large scale is still a challenge. In this talk, synthesis routes for WSe2 and MoS2 that achieve monolayer thickness uniformity across large area substrates with electrical properties equivalent to geological crystals will be described. Controlled doping of 2D semiconductors is also critically required. However, methods established for conventional semiconductors, such as ion implantation, are not easily applicable to 2D materials because of their atomically thin structure. Redox-active molecular dopants will be demonstrated which provide large changes in carrier density and workfunction through the choice of dopant, treatment time, and the solution concentration. Finally, several applications of these large-area, uniform 2D materials will be described including heterostructures, biosensors and strain sensors.

  11. 2D microwave imaging reflectometer electronics

    SciTech Connect

    Spear, A. G.; Domier, C. W. Hu, X.; Muscatello, C. M.; Ren, X.; Luhmann, N. C.; Tobias, B. J.

    2014-11-15

    A 2D microwave imaging reflectometer system has been developed to visualize electron density fluctuations on the DIII-D tokamak. Simultaneously illuminated at four probe frequencies, large aperture optics image reflections from four density-dependent cutoff surfaces in the plasma over an extended region of the DIII-D plasma. Localized density fluctuations in the vicinity of the plasma cutoff surfaces modulate the plasma reflections, yielding a 2D image of electron density fluctuations. Details are presented of the receiver down conversion electronics that generate the in-phase (I) and quadrature (Q) reflectometer signals from which 2D density fluctuation data are obtained. Also presented are details on the control system and backplane used to manage the electronics as well as an introduction to the computer based control program.

  12. 2D microwave imaging reflectometer electronics

    NASA Astrophysics Data System (ADS)

    Spear, A. G.; Domier, C. W.; Hu, X.; Muscatello, C. M.; Ren, X.; Tobias, B. J.; Luhmann, N. C.

    2014-11-01

    A 2D microwave imaging reflectometer system has been developed to visualize electron density fluctuations on the DIII-D tokamak. Simultaneously illuminated at four probe frequencies, large aperture optics image reflections from four density-dependent cutoff surfaces in the plasma over an extended region of the DIII-D plasma. Localized density fluctuations in the vicinity of the plasma cutoff surfaces modulate the plasma reflections, yielding a 2D image of electron density fluctuations. Details are presented of the receiver down conversion electronics that generate the in-phase (I) and quadrature (Q) reflectometer signals from which 2D density fluctuation data are obtained. Also presented are details on the control system and backplane used to manage the electronics as well as an introduction to the computer based control program.

  13. 2D microwave imaging reflectometer electronics.

    PubMed

    Spear, A G; Domier, C W; Hu, X; Muscatello, C M; Ren, X; Tobias, B J; Luhmann, N C

    2014-11-01

    A 2D microwave imaging reflectometer system has been developed to visualize electron density fluctuations on the DIII-D tokamak. Simultaneously illuminated at four probe frequencies, large aperture optics image reflections from four density-dependent cutoff surfaces in the plasma over an extended region of the DIII-D plasma. Localized density fluctuations in the vicinity of the plasma cutoff surfaces modulate the plasma reflections, yielding a 2D image of electron density fluctuations. Details are presented of the receiver down conversion electronics that generate the in-phase (I) and quadrature (Q) reflectometer signals from which 2D density fluctuation data are obtained. Also presented are details on the control system and backplane used to manage the electronics as well as an introduction to the computer based control program. PMID:25430247

  14. 2D-Crystal-Based Functional Inks.

    PubMed

    Bonaccorso, Francesco; Bartolotta, Antonino; Coleman, Jonathan N; Backes, Claudia

    2016-08-01

    The possibility to produce and process graphene, related 2D crystals, and heterostructures in the liquid phase makes them promising materials for an ever-growing class of applications as composite materials, sensors, in flexible optoelectronics, and energy storage and conversion. In particular, the ability to formulate functional inks with on-demand rheological and morphological properties, i.e., lateral size and thickness of the dispersed 2D crystals, is a step forward toward the development of industrial-scale, reliable, inexpensive printing/coating processes, a boost for the full exploitation of such nanomaterials. Here, the exfoliation strategies of graphite and other layered crystals are reviewed, along with the advances in the sorting of lateral size and thickness of the exfoliated sheets together with the formulation of functional inks and the current development of printing/coating processes of interest for the realization of 2D-crystal-based devices. PMID:27273554

  15. The 2D lingual appliance system.

    PubMed

    Cacciafesta, Vittorio

    2013-09-01

    The two-dimensional (2D) lingual bracket system represents a valuable treatment option for adult patients seeking a completely invisible orthodontic appliance. The ease of direct or simplified indirect bonding of 2D lingual brackets in combination with low friction mechanics makes it possible to achieve a good functional and aesthetic occlusion, even in the presence of a severe malocclusion. The use of a self-ligating bracket significantly reduces chair-side time for the orthodontist, and the low-profile bracket design greatly improves patient comfort. PMID:24005953

  16. Inkjet printing of 2D layered materials.

    PubMed

    Li, Jiantong; Lemme, Max C; Östling, Mikael

    2014-11-10

    Inkjet printing of 2D layered materials, such as graphene and MoS2, has attracted great interests for emerging electronics. However, incompatible rheology, low concentration, severe aggregation and toxicity of solvents constitute critical challenges which hamper the manufacturing efficiency and product quality. Here, we introduce a simple and general technology concept (distillation-assisted solvent exchange) to efficiently overcome these challenges. By implementing the concept, we have demonstrated excellent jetting performance, ideal printing patterns and a variety of promising applications for inkjet printing of 2D layered materials. PMID:25169938

  17. Measurement of 2D birefringence distribution

    NASA Astrophysics Data System (ADS)

    Noguchi, Masato; Ishikawa, Tsuyoshi; Ohno, Masahiro; Tachihara, Satoru

    1992-10-01

    A new measuring method of 2-D birefringence distribution has been developed. It has not been an easy job to get a birefringence distribution in an optical element with conventional ellipsometry because of its lack of scanning means. Finding an analogy between the rotating analyzer method in ellipsometry and the phase-shifting method in recently developed digital interferometry, we have applied the phase-shifting algorithm to ellipsometry, and have developed a new method that makes the measurement of 2-D birefringence distribution easy and possible. The system contains few moving parts, assuring reliability, and measures a large area of a sample at one time, making the measuring time very short.

  18. Overview of the Cumulus Humilis Aerosol Processing Study.

    SciTech Connect

    Berg, L. K.; Berkowitz, C. M.; Ogren, J. A.; Hostetler, C. A.; Ferrare, R. A.; Dubey, M.; Andrews, E.; Coulter, R. L.; Hair, J. W.; Hubbe, J. M.Lee, Y. N.; Mazzoleni, C; Olfert, J; Springston, SR; Environmental Science Division; PNNL; NOAA Earth System Research Lab.; NASA Langley Research Center; LANL; BNL; Univ.of Alberta; Univ. of Colorado

    2009-11-01

    Aerosols influence climate directly by scattering and absorbing radiation and indirectly through their influence on cloud microphysical and dynamical properties. The Intergovernmental Panel on Climate Change (IPCC) concluded that the global radiative forcing due to aerosols is large and in general cools the planet. But the uncertainties in these estimates are also large due to our poor understanding of many of the important processes related to aerosols and clouds. To address this uncertainty an integrated strategy for addressing issues related to aerosols and aerosol processes was proposed. Using this conceptual framework, the Cumulus Humilis Aerosol Processing Study (CHAPS) is a stage 1 activity, that is, a detailed process study. The specific focus of CHAPS was to provide concurrent observations of the chemical composition of the activated [particles that are currently serving as cloud condensation nuclei (CCN)] and nonactivated aerosols, the scattering and extinction profiles, and detailed aerosol and droplet size spectra in the vicinity of Oklahoma City, Oklahoma, during June 2007. Numerous campaigns have examined aerosol properties downwind from large pollution sources, including the Megacity Initiative: Local and Global Research Observations (MILAGRO) campaign and the two of the three Aerosol Characterization Experiments, ACE-2 and ACE-Asia. Other studies conducted near cities have examined changes in both aerosols and clouds downwind of urban areas. For example wintertime stratiform clouds associated with the urban plumes of Denver, Colorado, and Kansas City, Missouri, have a larger number concentration and smaller median volume diameter of droplets than clouds that had not been affected by the urban plume. Likewise, a decrease in precipitation in polluted regions along the Front Range of the Rocky Mountains was discovered. In a modeling study, it was found that precipitation downwind of urban areas may be influenced by changes in aerosols as well as the

  19. Individual bovine in vitro embryo production and cumulus cell transcriptomic analysis to distinguish cumulus-oocyte complexes with high or low developmental potential.

    PubMed

    Bunel, A; Jorssen, E P; Merckx, E; Leroy, J L; Bols, P E; Sirard, M A

    2015-01-15

    Studying cumulus cell (CC) transcriptome is of great interest as it could provide a noninvasive method to assess oocyte quality. In cattle, the search for quality markers has not been done with cumulus-oocyte complexes (COCs) cultured individually from maturation to blastocyst stage. Here, differences between high- and low-potential COCs were examined by transcriptomic analysis of CC biopsies obtained from COCs of 2 to 6 mm follicles (n = 249; eight replicates) before individual in vitro maturation, fertilization, and culture until Day 8 after fertilization. Each COC was individually tracked and categorized based on his fate: embryo at blastocyst stage (CC-Blast) or embryo arrested at 2- to 8-cell stage (CC-2-8-cells). Average blastocyst rates were 27.7% for individual culture and 31.2% for group control (not significantly different). For transcriptomic analysis, five cumulus biopsies per replicate were pooled for each fate. Three CC replicates underwent transcriptomic analysis using RNA microarray assay. Some clear differences in gene expression between the CC-Blast and the CC-2-8-cell groups were identified. Considering a 1.5-fold change (P < 0.05), 68 genes were differentially expressed between the CC-Blast and CC-2-8-cells. Quantitative reverse transcription-polymerase chain reaction validations were performed for 12 selected genes: six upregulated genes for each COC fate. Higher expression of 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9) (lipid metabolism), Chloride intracellular channel 3 (CLIC3), Keratin 8 (KRT8), and Lumican (LUM) (molecular transport) was observed in CC-2-8-cells (P < 0.05). The CC-Blast fate analysis revealed a significantly higher expression of Glycine amidinotransferase (L-arginine:glycine amidinotransferase) (GATM) (posttranslational modification, amino acid metabolism, and free radical scavenging). This newly identified set of genes could provide new markers to distinguish COCs associated with good quality embryos from COCs

  20. The Macroscopic Entrainment Processes of Simulated Cumulus Ensemble. Part II: Testing the Entraining-Plume Model.

    NASA Astrophysics Data System (ADS)

    Lin, Chichung; Arakawa, Akio

    1997-04-01

    According to Part I of this paper, it seems that ignoring the contribution from descendent cloud air in a cloud model for cumulus parameterization (CMCP), such as the spectral cumulus ensemble model in the Arakawa-Schubert parameterization, is an acceptable simplification for tropical deep convection. Since each subensemble in the spectral cumulus ensemble model is formally analogous to an entraining plume, the latter is examined using the simulated data from a cloud-resolving model (CRM). The authors first follow the analysis procedure of Warner. With the data from a nonprecipitating experiment, the authors show that the entraining-plume model cannot simultaneously predict the mean liquid water profile and cloud top height of the clouds simulated by the CRM. However, the mean properties of active elements of clouds, which are characterized by strong updrafts, can be described by an entraining plume of similar top height.With the data from a precipitating experiment, the authors examine the spectral cumulus ensemble model using the Paluch diagram. It is found that the spectral cumulus ensemble model appears adequate if different types of clouds in the spectrum are interpreted as subcloud elements with different entrainment characteristics. The resolved internal structure of clouds can thus be viewed as a manifestation of a cloud spectrum. To further investigate whether the fractional rate of entrainment is an appropriate parameter for characterizing cloud types in the spectral cumulus ensemble model, the authors stratify the simulated saturated updrafts (subcloud elements) into different types according to their eventual heights and calculate the cloud mass flux and mean moist static energy for each type. Entrainment characteristics are then inferred through the cloud mass flux and in-cloud moist static energy. It is found that different types of subcloud elements have distinguishable thermodynamic properties and entrainment characteristics. However, for each cloud

  1. Aerosol and Trace Gas Processing by Clouds During the Cumulus Humilis Aerosol Processing Study (CHAPS)

    NASA Astrophysics Data System (ADS)

    Yu, X.; Berg, L.; Berkowitz, C.; Alexander, L.; Lee, Y.; Ogren, J.; Andrews, B.

    2008-12-01

    Clouds play an active role in the processing and cycling of atmospheric constituents. Gases and particles can partition to cloud droplets by absorption and condensation as well as activation and pact scavenging. The Cumulus Humilis Aerosol Processing Study (CHAPS) aimed at characterizing freshly emitted aerosols above, within and below fields of cumulus humilis (or fair-weather cumulus) in the vicinity of Oklahoma City. The experiment took place in June 2007. Evolution of aerosol and cloud properties downwind of the Oklahoma City is of particular interest in this project. These observations of a mid-size and mid-latitude city can be used in the development and evaluation of regional-scale and global climate model cumulus parameterizations that describes the transport and transformations of these aerosols by fair-weather cumulus. The Department of Energy (DOE) G-1 aircraft was one of the main platforms used in CHAPS. It carried a suite of instruments to measure properties of interstitial aerosols behind an isokinetic inlet and a set of duplicate instruments to determine properties of activated particles behind a counter-flow virtual impactor (CVI). The sampling line to the Aerodyne Aerosol Mass Spectrometer was switched between the isokinetic inlet and the CVI to allow characterization of interstitial particles out of clouds in contrast to particles activated in clouds. Trace gases including ozone, carbon monoxide, sulfur dioxide, and a series of volatile organic compounds (VOCs) were also measured as were key meteorological state parameters including liquid water content, cloud drop size, and dew point temperature were measured. This presentation will focus on results related to the transformation and transport of aerosols and trace gases observed in fair-weather cumulus and compare these results with concurrent observations made outside these clouds. Our interest will focus on the differences in particle size and composition under varying conditions. The role of

  2. Parallel stitching of 2D materials

    DOE PAGESBeta

    Ling, Xi; Wu, Lijun; Lin, Yuxuan; Ma, Qiong; Wang, Ziqiang; Song, Yi; Yu, Lili; Huang, Shengxi; Fang, Wenjing; Zhang, Xu; et al

    2016-01-27

    Diverse parallel stitched 2D heterostructures, including metal–semiconductor, semiconductor–semiconductor, and insulator–semiconductor, are synthesized directly through selective “sowing” of aromatic molecules as the seeds in the chemical vapor deposition (CVD) method. Lastly, the methodology enables the large-scale fabrication of lateral heterostructures, which offers tremendous potential for its application in integrated circuits.

  3. Parallel Stitching of 2D Materials.

    PubMed

    Ling, Xi; Lin, Yuxuan; Ma, Qiong; Wang, Ziqiang; Song, Yi; Yu, Lili; Huang, Shengxi; Fang, Wenjing; Zhang, Xu; Hsu, Allen L; Bie, Yaqing; Lee, Yi-Hsien; Zhu, Yimei; Wu, Lijun; Li, Ju; Jarillo-Herrero, Pablo; Dresselhaus, Mildred; Palacios, Tomás; Kong, Jing

    2016-03-01

    Diverse parallel stitched 2D heterostructures, including metal-semiconductor, semiconductor-semiconductor, and insulator-semiconductor, are synthesized directly through selective "sowing" of aromatic molecules as the seeds in the chemical vapor deposition (CVD) method. The methodology enables the large-scale fabrication of lateral heterostructures, which offers tremendous potential for its application in integrated circuits. PMID:26813882

  4. Baby universes in 2d quantum gravity

    NASA Astrophysics Data System (ADS)

    Ambjørn, Jan; Jain, Sanjay; Thorleifsson, Gudmar

    1993-06-01

    We investigate the fractal structure of 2d quantum gravity, both for pure gravity and for gravity coupled to multiple gaussian fields and for gravity coupled to Ising spins. The roughness of the surfaces is described in terms of baby universes and using numerical simulations we measure their distribution which is related to the string susceptibility exponent γstring.

  5. Transcript of proceedings: National Aeronautics and Space Administration, Goddard Space Flight Center, 1972 GSFC Battery Workshop, first day

    NASA Technical Reports Server (NTRS)

    1972-01-01

    The proceedings of the 1972 NASA/Goddard Battery Workshop are reported. Topics discussed include: separators, materials and processing, test and storage experience, and improved energy density systems.

  6. Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis

    PubMed Central

    Dell'Aquila, Maria Elena; Caillaud, Maud; Maritato, Filippo; Martoriati, Alain; Gérard, Nadine; Aiudi, Giulio; Minoia, Paolo; Goudet, Ghylène

    2004-01-01

    The aim of this study was to investigate cumulus expansion, nuclear maturation and expression of connexin 43, cyclooxygenase-2 and FSH receptor transcripts in equine cumuli oophori during in vivo and in vitro maturation in the presence of equine FSH (eFSH) and precursors for hyaluronic acid synthesis. Equine cumulus-oocyte complexes (COC) were cultured in a control defined medium supplemented with eFSH (0 to 5 micrograms/ml), Fetal Calf Serum (FCS), precursors for hyaluronic acid synthesis or glutamine according to the experiments. After in vitro maturation, the cumulus expansion rate was increased with 1 microgram/ml eFSH, and was the highest with 20% FCS. It was not influenced by precursors for hyaluronic acid synthesis or glutamine. The expression of transcripts related to cumulus expansion was analyzed in equine cumulus cells before maturation, and after in vivo and in vitro maturation, by using reverse transcription-polymerase chain reaction (RT-PCR) with specific primers. Connexin 43, cyclooxygenase-2 (COX-2) and FSH receptor (FSHr) mRNA were detected in equine cumulus cells before and after maturation. Their level did not vary during in vivo or in vitro maturation and was influenced neither by FSH nor by precursors for hyaluronic acid synthesis. Results indicate that previously reported regulation of connexin 43 and COX-2 proteins during equine COC maturation may involve post-transcriptional mechanisms. PMID:15212696

  7. 1988 Goddard Conference on Space Applications of Artificial Intelligence, Greenbelt, MD, May 24, 1988, Proceedings

    NASA Technical Reports Server (NTRS)

    Rash, James L. (Editor)

    1988-01-01

    This publication comprises the papers presented at the 1988 Goddard Conference on Space Applications of Artificial Intelligence held at the NASA/Goddard Space Flight Center, Greenbelt, Maryland on May 24, 1988. The purpose of this annual conference is to provide a forum in which current research and development directed at space applications of artificial intelligence can be presented and discussed. The papers in these proceedings fall into the following areas: mission operations support, planning and scheduling; fault isolation/diagnosis; image processing and machine vision; data management; modeling and simulation; and development tools methodologies.

  8. Recent progress in the NASA-Goddard Space Flight Center atomic hydrogen standards program

    NASA Technical Reports Server (NTRS)

    Reinhardt, V. S.

    1981-01-01

    At NASA Goddard Space Flight Center and through associated contractors, a broad spectrum of work is being carried out to develop improved hydrogen maser frequency standards for field use, improved experimental hydrogen maser frequency standards, and improved frequency and time distribution and measurement systems for hydrogen maser use. Recent progress in the following areas is reported: results on the Nr masers built by the Applied Physics Laboratory of Johns Hopkins University, the development of a low cost hydrogen maser at Goddard Space Flight Center, and work on a low noise phase comparison system and digitally phase locked crystal oscillator called the distribution and measurement system.

  9. Glenn Goddard TDRSS Waveform 1.1.3 On-Orbit Performance Report

    NASA Technical Reports Server (NTRS)

    Chelmins, David T.

    2014-01-01

    The objective of the Space Communications and Navigation (SCaN) Testbed is to study the development, testing, and operation of software defined radios (SDRs) and their associated appliations in the operational space environment to reduce cost and risk for future space missions. This report covers the results of on-orbit performance testing completed using the Glenn Goddard Tracking and Data Relay Satellite System (TDRSS) waveform version 1.1.3 in the ground and space environments. The Glenn Goddard TDRSS (GGT) waveform, operating on the SCaN Testbed Jet Propulsion Laboratory (JPL) SDR, is capable of a variety of data rates and frequencies, operating using Binary Phase Shift Keying (BPSK).

  10. A study of the longevity and operational reliability of Goddard Spacecraft, 1960-1980

    NASA Technical Reports Server (NTRS)

    Shockey, E. F.

    1981-01-01

    Compiled data regarding the design lives and lifetimes actually achieved by 104 orbiting satellites launched by the Goddard Spaceflight Center between the years 1960 and 1980 is analyzed. Historical trends over the entire 21 year period are reviewed, and the more recent data is subjected to an examination of several key parameters. An empirical reliability function is derived, and compared with various mathematical models. Data from related studies is also discussed. The results provide insight into the reliability history of Goddard spacecraft an guidance for estimating the reliability of future programs.

  11. Application of 2D Non-Graphene Materials and 2D Oxide Nanostructures for Biosensing Technology

    PubMed Central

    Shavanova, Kateryna; Bakakina, Yulia; Burkova, Inna; Shtepliuk, Ivan; Viter, Roman; Ubelis, Arnolds; Beni, Valerio; Starodub, Nickolaj; Yakimova, Rositsa; Khranovskyy, Volodymyr

    2016-01-01

    The discovery of graphene and its unique properties has inspired researchers to try to invent other two-dimensional (2D) materials. After considerable research effort, a distinct “beyond graphene” domain has been established, comprising the library of non-graphene 2D materials. It is significant that some 2D non-graphene materials possess solid advantages over their predecessor, such as having a direct band gap, and therefore are highly promising for a number of applications. These applications are not limited to nano- and opto-electronics, but have a strong potential in biosensing technologies, as one example. However, since most of the 2D non-graphene materials have been newly discovered, most of the research efforts are concentrated on material synthesis and the investigation of the properties of the material. Applications of 2D non-graphene materials are still at the embryonic stage, and the integration of 2D non-graphene materials into devices is scarcely reported. However, in recent years, numerous reports have blossomed about 2D material-based biosensors, evidencing the growing potential of 2D non-graphene materials for biosensing applications. This review highlights the recent progress in research on the potential of using 2D non-graphene materials and similar oxide nanostructures for different types of biosensors (optical and electrochemical). A wide range of biological targets, such as glucose, dopamine, cortisol, DNA, IgG, bisphenol, ascorbic acid, cytochrome and estradiol, has been reported to be successfully detected by biosensors with transducers made of 2D non-graphene materials. PMID:26861346

  12. Application of 2D Non-Graphene Materials and 2D Oxide Nanostructures for Biosensing Technology.

    PubMed

    Shavanova, Kateryna; Bakakina, Yulia; Burkova, Inna; Shtepliuk, Ivan; Viter, Roman; Ubelis, Arnolds; Beni, Valerio; Starodub, Nickolaj; Yakimova, Rositsa; Khranovskyy, Volodymyr

    2016-01-01

    The discovery of graphene and its unique properties has inspired researchers to try to invent other two-dimensional (2D) materials. After considerable research effort, a distinct "beyond graphene" domain has been established, comprising the library of non-graphene 2D materials. It is significant that some 2D non-graphene materials possess solid advantages over their predecessor, such as having a direct band gap, and therefore are highly promising for a number of applications. These applications are not limited to nano- and opto-electronics, but have a strong potential in biosensing technologies, as one example. However, since most of the 2D non-graphene materials have been newly discovered, most of the research efforts are concentrated on material synthesis and the investigation of the properties of the material. Applications of 2D non-graphene materials are still at the embryonic stage, and the integration of 2D non-graphene materials into devices is scarcely reported. However, in recent years, numerous reports have blossomed about 2D material-based biosensors, evidencing the growing potential of 2D non-graphene materials for biosensing applications. This review highlights the recent progress in research on the potential of using 2D non-graphene materials and similar oxide nanostructures for different types of biosensors (optical and electrochemical). A wide range of biological targets, such as glucose, dopamine, cortisol, DNA, IgG, bisphenol, ascorbic acid, cytochrome and estradiol, has been reported to be successfully detected by biosensors with transducers made of 2D non-graphene materials. PMID:26861346

  13. Sensitivity of hurricane forecasts to cumulus parameterizations in the HWRF model

    NASA Astrophysics Data System (ADS)

    Biswas, Mrinal K.; Bernardet, Ligia; Dudhia, Jimy

    2014-12-01

    The Developmental Testbed Center used the Hurricane Weather Research and Forecasting (HWRF) system to test the sensitivity of tropical cyclone track and intensity forecasts to different convective schemes. A control configuration that employed the HWRF Simplified Arakawa Scheme (SAS) was compared with the Kain-Fritsch and Tiedtke schemes, as well as with a newer implementation of the SAS. A comprehensive test for Atlantic and Eastern North Pacific storms shows that the SAS scheme produces the best track forecasts. Even though the convective parameterization was absent in the inner 3 km nest, the intensity forecasts are sensitive to the choice of cumulus scheme on the outer grids. The impact of convective-scale heating on the environmental flow accumulates in time since the hurricane vortex is cycled in the HWRF model initialization. This study shows that, for a given forecast, the sensitivity to cumulus parameterization combines the influence of physics and initial conditions.

  14. Dependence of entrainment in shallow cumulus convection on vertical velocity and distance to cloud edge

    NASA Astrophysics Data System (ADS)

    Tian, Yang; Kuang, Zhiming

    2016-04-01

    The dependence of entrainment rate on environmental conditions and cloud characteristics is investigated using large eddy simulations (LES) of the response of shallow cumulus convection to a small-amplitude temperature perturbation that is horizontally uniform and localized in height. The simulated cumulus fields are analyzed in the framework of an ensemble of entraining plumes by tracking a large number of Lagrangian parcels embedded in the LES and grouping them into different plumes based on their detrainment heights. The results show that fractional entrainment rate per unit height of a plume is inversely proportional to the plume's vertical velocity and its distance to the cloud edge, while changes in environmental stratification and relative humidity, the plume's buoyancy, or the vertical gradient of its buoyancy due to the temperature perturbation have little effect on the plume's entrainment rate.

  15. Effects of cumulus entrainment and multiple cloud types on a January global climate model simulation

    NASA Technical Reports Server (NTRS)

    Yao, Mao-Sung; Del Genio, Anthony D.

    1989-01-01

    An improved version of the GISS Model II cumulus parameterization designed for long-term climate integrations is used to study the effects of entrainment and multiple cloud types on the January climate simulation. Instead of prescribing convective mass as a fixed fraction of the cloud base grid-box mass, it is calculated based on the closure assumption that the cumulus convection restores the atmosphere to a neutral moist convective state at cloud base. This change alone significantly improves the distribution of precipitation, convective mass exchanges, and frequencies in the January climate. The vertical structure of the tropical atmosphere exhibits quasi-equilibrium behavior when this closure is used, even though there is no explicit constraint applied above cloud base.

  16. A cumulus parameterization scheme designed for nested grid meso-{beta} scale models

    SciTech Connect

    Weissbluth, M.J.; Cotton, W.R.

    1991-12-31

    A generalized cumulus parameterization based upon higher order turbulence closure has been incorporated into one dimensional simulations. The scheme consists of a level 2.5w turbulence closure scheme mated with a convective adjustment scheme. The convective adjustment scheme includes a gradient term which can be interpreted as either a subsidence term when the scheme is used in large scale models or a mesoscale compensation term when the scheme is used in mesoscale models. The scheme also includes a convective adjustment term which is interpreted as a detrainment term in large scale models. In mesoscale models, the mesoscale compensation term and the advection by the mean vertical motions combine to yield no net advection which is desirable since the convective moistening and heating is now wholly accomplished by the convective adjustment term; double counting is then explicitly eliminated. One dimensional simulations indicate satisfactory performance of the cumulus parameterization scheme for a non-entraining updraft.

  17. A cumulus parameterization scheme designed for nested grid meso-. beta. scale models

    SciTech Connect

    Weissbluth, M.J.; Cotton, W.R.

    1991-01-01

    A generalized cumulus parameterization based upon higher order turbulence closure has been incorporated into one dimensional simulations. The scheme consists of a level 2.5w turbulence closure scheme mated with a convective adjustment scheme. The convective adjustment scheme includes a gradient term which can be interpreted as either a subsidence term when the scheme is used in large scale models or a mesoscale compensation term when the scheme is used in mesoscale models. The scheme also includes a convective adjustment term which is interpreted as a detrainment term in large scale models. In mesoscale models, the mesoscale compensation term and the advection by the mean vertical motions combine to yield no net advection which is desirable since the convective moistening and heating is now wholly accomplished by the convective adjustment term; double counting is then explicitly eliminated. One dimensional simulations indicate satisfactory performance of the cumulus parameterization scheme for a non-entraining updraft.

  18. Modification of cumulus convection and planetary boundary layer schemes in the GRAPES global model

    NASA Astrophysics Data System (ADS)

    Liu, Kun; Chen, Qiying; Sun, Jian

    2015-10-01

    Cumulus convection is a key linkage between hydrological cycle and large-scale atmospheric circulation. Cumulus parameterization scheme is an important component in numerical weather and climate modeling studies. In the Global/Regional Assimilation and Prediction Enhanced System (GRAPES), turbulent mixing and diffusion approach is applied in its shallow convection scheme. This method overestimates the vertical transport of heat and moisture fluxes but underestimates cloud water mixing ratio over the region of stratocumulus clouds. As a result, the simulated low stratocumulus clouds are less than observations. To overcome this problem, a mass flux method is employed in the shallow convection scheme to replace the original one. Meanwhile, the deep convection scheme is adjusted correspondingly. This modification is similar to that in the US NCEP Global Forecast System (GFS), which uses the simplified Arakawa Schubert Scheme (SAS). The planetary boundary layer scheme (PBL) is also revised by considering the coupling between the PBL and stratocumulus clouds. With the modification of both the cumulus and PBL schemes, the GRAPES simulation of shallow convective heating rate becomes more reasonable; total amounts of stratocumulus clouds simulated over the eastern Pacific and their vertical structure are more consistent with observations; the underestimation of stratocumulus clouds simulated by original schemes is less severe with the revised schemes. Precipitation distribution in the tropics becomes more reasonable and spurious precipitation is effectively suppressed. The westward extension and northward movement of the western Pacific subtropical high simulated with the revised schemes are more consistent with Final Operational Global Analysis (FNL) than that simulated with the original schemes. The statistical scores for the global GRAPES forecast are generally improved with the revised schemes, especially for the simulation of geopotential height in the Northern

  19. Cumulus Cell Transcripts Transit to the Bovine Oocyte in Preparation for Maturation.

    PubMed

    Macaulay, Angus D; Gilbert, Isabelle; Scantland, Sara; Fournier, Eric; Ashkar, Fazl; Bastien, Alexandre; Saadi, Habib A Shojaei; Gagné, Dominic; Sirard, Marc-André; Khandjian, Édouard W; Richard, François J; Hyttel, Poul; Robert, Claude

    2016-01-01

    So far, the characteristics of a good quality egg have been elusive, similar to the nature of the physiological, cellular, and molecular cues leading to its production both in vivo and in vitro. Current understanding highlights a strong and complex interdependence between the follicular cells and the gamete. Secreted factors induce cellular responses in the follicular cells, and direct exchange of small molecules from the cumulus cells to the oocyte through gap junctions controls meiotic arrest. Studying the interconnection between the cumulus cells and the oocyte, we previously demonstrated that the somatic cells also contribute transcripts to the gamete. Here, we show that these transcripts can be visualized moving down the transzonal projections (TZPs) to the oocyte, and that a time course analysis revealed progressive RNA accumulation in the TZPs, indicating that RNA transfer occurs before the initiation of meiosis resumption under a timetable fitting with the acquisition of developmental competence. A comparison of the identity of the nascent transcripts trafficking in the TZPs, with those in the oocyte increasing in abundance during maturation, and that are present on the oocyte's polyribosomes, revealed transcripts common to all three fractions, suggesting the use of transferred transcripts for translation. Furthermore, the removal of potential RNA trafficking by stripping the cumulus cells caused a significant reduction in maturation rates, indicating the need for the cumulus cell RNA transfer to the oocyte. These results offer a new perspective to the determinants of oocyte quality and female fertility, as well as provide insight that may eventually be used to improve in vitro maturation conditions. PMID:26586844

  20. Can in situ measurements be used to estimate the age of shallow cumulus clouds?

    NASA Astrophysics Data System (ADS)

    Witte, M.; Chuang, P. Y.

    2010-12-01

    Cumulus clouds exhibit a life cycle that consists of: a) the growth phase (increasing size, most notably in the vertical direction); b) mature phase (growth no longer occurs; any precipitation that develops is strongest during this period); and c) dissipation phase (cloud dissipates because of precipitation and/or entrainment; no more dynamical support). Radar can track clouds over time and give some sense of the age of each cloud, but most aircraft measurements are without a temporal context. If it is possible, determining the cloud age (even if it is approximate, i.e. determining the phase in its life cycle) based solely on in situ measurements could provide important context information. The existence of such a measure would be a useful tool for interpreting past and future in situ cloud measurements. We use LES model simulations of trade wind cumulus cloud fields from one case during the Barbados Oceanographic and Meteorological Experiment (BOMEX) to test several potential cumulus cloud “clocks.” One key metric is the in-cloud buoyancy perturbation from the clear air mean as a function of time, as measured by virtual potential temperature. In general, the mean buoyancy of a cloud initially increases from zero with time, peaks, and decreases to become negatively buoyant during the latter third of its life cycle, with the amplitude of buoyancy dependent on cloud size. In some cases (more commonly for larger clouds), multiple pulses of buoyancy occur, which complicate any potential cumulus clock (as also reported by Heus et al., 2009). Since the buoyancy perturbation is not single-valued over the life of a given cloud, nor is the magnitude of the perturbation sufficient to differentiate between a mature small cloud or a growing larger cloud, other parameters must be used in addition to cloud buoyancy to construct a useful in situ cloud clock.

  1. A method for retrieving the cumulus entrainment rate from ground based observations

    NASA Astrophysics Data System (ADS)

    Wagner, Timothy J.

    2011-12-01

    The entrainment of drier environmental air into cumulus clouds affects the impact that these clouds have on the environment by modifying their radiative, microphysical, and thermodynamic characteristics. Entrainment is a difficult parameter to observe directly, and heretofore has been obtained from occasional aircraft penetrations. To increase the number of cumulus entrainment rate observations under a wide range of atmospheric conditions, an algorithm for retrieving the cumulus entrainment rate from ground-based remote sensing observations has been developed. This algorithm, called the Entrainment Rate In Cumulus Algorithm (ERICA), uses the suite of instruments at the Southern Great Plains (SGP) site of the United States Department of Energy's Atmospheric Radiation Measurement (ARM) Climate Research Facility as inputs into a Gauss-Newton optimal estimation scheme. The forward model in this algorithm is the Explicit Mixing Parcel Model (EMPM), a cloud parcel model that treats entrainment as a series of discrete mixing events. Output from EMPM is used to calculate quantities that can be observed from the surface, including effective radius and liquid water path. The entrainment rate in EMPM is adjusted iteratively until the modeled output converges to the observations. Sensitivity testing and error and information content analysis show that ERICA is a robust method for obtaining accurate estimates of entrainment rate without the drawbacks of aircraft observations. Results from a three-month trial of ERICA show significant variability of the entrainment rate of clouds in a single day and from one day to the next. The mean value from this analysis corresponds well with prior knowledge of the entrainment rate.

  2. Static & Dynamic Response of 2D Solids

    1996-07-15

    NIKE2D is an implicit finite-element code for analyzing the finite deformation, static and dynamic response of two-dimensional, axisymmetric, plane strain, and plane stress solids. The code is fully vectorized and available on several computing platforms. A number of material models are incorporated to simulate a wide range of material behavior including elasto-placicity, anisotropy, creep, thermal effects, and rate dependence. Slideline algorithms model gaps and sliding along material interfaces, including interface friction, penetration and single surfacemore » contact. Interactive-graphics and rezoning is included for analyses with large mesh distortions. In addition to quasi-Newton and arc-length procedures, adaptive algorithms can be defined to solve the implicit equations using the solution language ISLAND. Each of these capabilities and more make NIKE2D a robust analysis tool.« less

  3. Stochastic Inversion of 2D Magnetotelluric Data

    2010-07-01

    The algorithm is developed to invert 2D magnetotelluric (MT) data based on sharp boundary parametrization using a Bayesian framework. Within the algorithm, we consider the locations and the resistivity of regions formed by the interfaces are as unknowns. We use a parallel, adaptive finite-element algorithm to forward simulate frequency-domain MT responses of 2D conductivity structure. Those unknown parameters are spatially correlated and are described by a geostatistical model. The joint posterior probability distribution function ismore » explored by Markov Chain Monte Carlo (MCMC) sampling methods. The developed stochastic model is effective for estimating the interface locations and resistivity. Most importantly, it provides details uncertainty information on each unknown parameter. Hardware requirements: PC, Supercomputer, Multi-platform, Workstation; Software requirements C and Fortan; Operation Systems/version is Linux/Unix or Windows« less

  4. Stochastic Inversion of 2D Magnetotelluric Data

    SciTech Connect

    Chen, Jinsong

    2010-07-01

    The algorithm is developed to invert 2D magnetotelluric (MT) data based on sharp boundary parametrization using a Bayesian framework. Within the algorithm, we consider the locations and the resistivity of regions formed by the interfaces are as unknowns. We use a parallel, adaptive finite-element algorithm to forward simulate frequency-domain MT responses of 2D conductivity structure. Those unknown parameters are spatially correlated and are described by a geostatistical model. The joint posterior probability distribution function is explored by Markov Chain Monte Carlo (MCMC) sampling methods. The developed stochastic model is effective for estimating the interface locations and resistivity. Most importantly, it provides details uncertainty information on each unknown parameter. Hardware requirements: PC, Supercomputer, Multi-platform, Workstation; Software requirements C and Fortan; Operation Systems/version is Linux/Unix or Windows

  5. Explicit 2-D Hydrodynamic FEM Program

    1996-08-07

    DYNA2D* is a vectorized, explicit, two-dimensional, axisymmetric and plane strain finite element program for analyzing the large deformation dynamic and hydrodynamic response of inelastic solids. DYNA2D* contains 13 material models and 9 equations of state (EOS) to cover a wide range of material behavior. The material models implemented in all machine versions are: elastic, orthotropic elastic, kinematic/isotropic elastic plasticity, thermoelastoplastic, soil and crushable foam, linear viscoelastic, rubber, high explosive burn, isotropic elastic-plastic, temperature-dependent elastic-plastic. Themore » isotropic and temperature-dependent elastic-plastic models determine only the deviatoric stresses. Pressure is determined by one of 9 equations of state including linear polynomial, JWL high explosive, Sack Tuesday high explosive, Gruneisen, ratio of polynomials, linear polynomial with energy deposition, ignition and growth of reaction in HE, tabulated compaction, and tabulated.« less

  6. Schottky diodes from 2D germanane

    NASA Astrophysics Data System (ADS)

    Sahoo, Nanda Gopal; Esteves, Richard J.; Punetha, Vinay Deep; Pestov, Dmitry; Arachchige, Indika U.; McLeskey, James T.

    2016-07-01

    We report on the fabrication and characterization of a Schottky diode made using 2D germanane (hydrogenated germanene). When compared to germanium, the 2D structure has higher electron mobility, an optimal band-gap, and exceptional stability making germanane an outstanding candidate for a variety of opto-electronic devices. One-atom-thick sheets of hydrogenated puckered germanium atoms have been synthesized from a CaGe2 framework via intercalation and characterized by XRD, Raman, and FTIR techniques. The material was then used to fabricate Schottky diodes by suspending the germanane in benzonitrile and drop-casting it onto interdigitated metal electrodes. The devices demonstrate significant rectifying behavior and the outstanding potential of this material.

  7. Statistical analysis of an LES shallow cumulus cloud ensemble using a cloud tracking algorithm

    NASA Astrophysics Data System (ADS)

    Dawe, J. T.; Austin, P. H.

    2012-01-01

    A technique for the tracking of individual clouds in a Large Eddy Simulation (LES) is presented. We use this technique on an LES of a shallow cumulus cloud field based upon the Barbados Oceanographic and Meteorological Experiment (BOMEX) to calculate statistics of cloud height, lifetime, and other physical properties for individual clouds in the model. We also examine the question of nature versus nurture in shallow cumulus clouds: do properties at cloud base determine the upper-level properties of the clouds (nature), or are cloud properties determined by the environmental conditions they encounter (nurture). We find that clouds which ascend through an environment that has been pre-moistened by previous cloud activity are no more likely to reach the inversion than clouds that ascend through a drier environment. Cloud base thermodynamic properties are uncorrelated with upper-level cloud properties, while mean fractional entrainment and detrainment rates display moderate correlations with cloud properties up to the inversion. Conversely, cloud base area correlates well with upper-level cloud area and maximum cloud height. We conclude that cloud thermodynamic properties are primarily influenced by entrainment and detrainment processes, cloud area and height are primarily influenced by cloud base area, and thus nature and nurture both play roles in the dynamics of BOMEX shallow cumulus clouds.

  8. Statistical analysis of a LES shallow cumulus cloud ensemble using a cloud tracking algorithm

    NASA Astrophysics Data System (ADS)

    Dawe, J. T.; Austin, P. H.

    2011-08-01

    A technique for the tracking of individual clouds in a Large Eddy Simulation (LES) is presented. We use this technique on a LES of a shallow cumulus cloud field based upon the Barbados Oceanographic and Meteorological Experiment (BOMEX) to calculate statistics of cloud height, lifetime, and other physical properties for individual clouds in the model. We also examine the question of nature versus nurture in shallow cumulus clouds: do properties at cloud base determine the upper-level properties of the clouds (nature), or are cloud properties determined by the environmental conditions they encounter (nurture). We find that clouds which ascend through an environment that has been pre-moistened by previous cloud activity are no more likely to reach the inversion than clouds that ascend through a drier environment. Cloud base thermodynamic properties are uncorrelated with upper-level cloud properties, while mean fractional entrainment and detrainment rate displays moderate correlations with cloud properties up to the inversion. Conversely, cloud base area correlates well with upper-level cloud area and maximum cloud height. We conclude that cloud thermodynamic properties are primarily influenced by entrainment and detrainment processes, cloud area and height are primarily influenced by cloud base area, and thus nature and nurture both play roles in the dynamics of BOMEX shallow cumulus clouds.

  9. Cumulus cell gene expression associated with pre-ovulatory acquisition of developmental competence in bovine oocytes.

    PubMed

    Bunel, A; Nivet, A L; Blondin, P; Vigneault, C; Richard, F J; Sirard, M A

    2014-01-01

    The final days before ovulation impact significantly on follicular function and oocyte quality. This study investigated the cumulus cell (CC) transcriptomic changes during the oocyte developmental competence acquisition period. Six dairy cows were used for 24 oocyte collections and received FSH twice daily over 3 days, followed by FSH withdrawal for 20, 44, 68 and 92 h in four different oestrous cycles for each of the six cows. Half of the cumulus-oocyte complexes were subjected to in vitro maturation, fertilisation and culture to assess blastocyst rate. The other half of the CC underwent microarray analysis (n=3 cows, 12 oocyte collections) and qRT-PCR (n=3 other cows, 12 oocyte collections). According to blastocyst rates, 20 h of FSH withdrawal led to under-differentiated follicles (49%), 44 and 68 h to the most competent follicles (71% and 61%) and 92 h to over-differentiated ones (51%). Ten genes, from the gene lists corresponding to the three different follicular states, were subjected to qRT-PCR. Interestingly, CYP11A1 and NSDHL gene expression profiles reflected the blastocyst rate. However most genes were associated with the over-differentiated status: GATM, MAN1A1, VNN1 and NRP1. The early period of FSH withdrawal has a minimal effect on cumulus gene expression, whereas the longest period has a very significant one and indicates the beginning of the atresia process. PMID:23827322

  10. FSH in vitro versus LH in vivo: similar genomic effects on the cumulus

    PubMed Central

    2013-01-01

    The use of gonadotropins to trigger oocyte maturation both in vivo and in vitro has provided precious and powerful knowledge that has significantly increased our understanding of the ovarian function. Moreover, the efficacy of most assisted reproductive technologies (ART) used in both humans and livestock species relies on gonadotropin input, mainly FSH and LH. Despite the significant progress achieved and the huge impact of gonadotropins, the exact molecular pathways of the two pituitary hormones, FSH and LH, still remain poorly understood. Moreover, these pathways may not be the same when moving from the in vivo to the in vitro context. This misunderstanding of the intricate synergy between these two hormones leads to a lack of consensus about their use mainly in vitro or in ovulation induction schedules in vivo. In order to optimize their use, additional work is thus required with a special focus on comparing the in vitro versus the in vivo effects. In this context, this overview will briefly summarize the downstream gene expression pathways induced by both FSH in vitro and LH in vivo in the cumulus compartment. Based on recent microarray comparative analysis, we are reporting that in vitro FSH stimulation on cumulus cells appears to achieve at least part of the gene expression activity after in vivo LH stimulation. We are then proposing that the in vitro FSH-response of cumulus cells have similitudes with the in vivo LH-response. PMID:24066945

  11. Layer Engineering of 2D Semiconductor Junctions.

    PubMed

    He, Yongmin; Sobhani, Ali; Lei, Sidong; Zhang, Zhuhua; Gong, Yongji; Jin, Zehua; Zhou, Wu; Yang, Yingchao; Zhang, Yuan; Wang, Xifan; Yakobson, Boris; Vajtai, Robert; Halas, Naomi J; Li, Bo; Xie, Erqing; Ajayan, Pulickel

    2016-07-01

    A new concept for junction fabrication by connecting multiple regions with varying layer thicknesses, based on the thickness dependence, is demonstrated. This type of junction is only possible in super-thin-layered 2D materials, and exhibits similar characteristics as p-n junctions. Rectification and photovoltaic effects are observed in chemically homogeneous MoSe2 junctions between domains of different thicknesses. PMID:27136275

  12. 2dF mechanical engineering

    NASA Astrophysics Data System (ADS)

    Smith, Greg; Lankshear, Allan

    1998-07-01

    2dF is a multi-object instrument mounted at prime focus at the AAT capable of spectroscopic analysis of 400 objects in a single 2 degree field. It also prepares a second 2 degree 400 object field while the first field is being observed. At its heart is a high precision robotic positioner that places individual fiber end magnetic buttons on one of two field plates. The button gripper is carried on orthogonal gantries powered by linear synchronous motors and contains a TV camera which precisely locates backlit buttons to allow placement in user defined locations to 10 (mu) accuracy. Fiducial points on both plates can also be observed by the camera to allow repeated checks on positioning accuracy. Field plates rotate to follow apparent sky rotation. The spectrographs both analyze light from the 200 observing fibers each and back- illuminate the 400 fibers being re-positioned during the observing run. The 2dF fiber position and spectrograph system is a large and complex instrument located at the prime focus of the Anglo Australian Telescope. The mechanical design has departed somewhat from the earlier concepts of Gray et al, but still reflects the audacity of those first ideas. The positioner is capable of positioning 400 fibers on a field plate while another 400 fibers on another plate are observing at the focus of the telescope and feeding the twin spectrographs. When first proposed it must have seemed like ingenuity unfettered by caution. Yet now it works, and works wonderfully well. 2dF is a system which functions as the result of the combined and coordinated efforts of the astronomers, the mechanical designers and tradespeople, the electronic designers, the programmers, the support staff at the telescope, and the manufacturing subcontractors. The mechanical design of the 2dF positioner and spectrographs was carried out by the mechanical engineering staff of the AAO and the majority of the manufacture was carried out in the AAO workshops.

  13. Realistic and efficient 2D crack simulation

    NASA Astrophysics Data System (ADS)

    Yadegar, Jacob; Liu, Xiaoqing; Singh, Abhishek

    2010-04-01

    Although numerical algorithms for 2D crack simulation have been studied in Modeling and Simulation (M&S) and computer graphics for decades, realism and computational efficiency are still major challenges. In this paper, we introduce a high-fidelity, scalable, adaptive and efficient/runtime 2D crack/fracture simulation system by applying the mathematically elegant Peano-Cesaro triangular meshing/remeshing technique to model the generation of shards/fragments. The recursive fractal sweep associated with the Peano-Cesaro triangulation provides efficient local multi-resolution refinement to any level-of-detail. The generated binary decomposition tree also provides efficient neighbor retrieval mechanism used for mesh element splitting and merging with minimal memory requirements essential for realistic 2D fragment formation. Upon load impact/contact/penetration, a number of factors including impact angle, impact energy, and material properties are all taken into account to produce the criteria of crack initialization, propagation, and termination leading to realistic fractal-like rubble/fragments formation. The aforementioned parameters are used as variables of probabilistic models of cracks/shards formation, making the proposed solution highly adaptive by allowing machine learning mechanisms learn the optimal values for the variables/parameters based on prior benchmark data generated by off-line physics based simulation solutions that produce accurate fractures/shards though at highly non-real time paste. Crack/fracture simulation has been conducted on various load impacts with different initial locations at various impulse scales. The simulation results demonstrate that the proposed system has the capability to realistically and efficiently simulate 2D crack phenomena (such as window shattering and shards generation) with diverse potentials in military and civil M&S applications such as training and mission planning.

  14. Compact 2-D graphical representation of DNA

    NASA Astrophysics Data System (ADS)

    Randić, Milan; Vračko, Marjan; Zupan, Jure; Novič, Marjana

    2003-05-01

    We present a novel 2-D graphical representation for DNA sequences which has an important advantage over the existing graphical representations of DNA in being very compact. It is based on: (1) use of binary labels for the four nucleic acid bases, and (2) use of the 'worm' curve as template on which binary codes are placed. The approach is illustrated on DNA sequences of the first exon of human β-globin and gorilla β-globin.

  15. 2D materials: Graphene and others

    NASA Astrophysics Data System (ADS)

    Bansal, Suneev Anil; Singh, Amrinder Pal; Kumar, Suresh

    2016-05-01

    Present report reviews the recent advancements in new atomically thick 2D materials. Materials covered in this review are Graphene, Silicene, Germanene, Boron Nitride (BN) and Transition metal chalcogenides (TMC). These materials show extraordinary mechanical, electronic and optical properties which make them suitable candidates for future applications. Apart from unique properties, tune-ability of highly desirable properties of these materials is also an important area to be emphasized on.

  16. TACO (2D AND 3D). Taco

    SciTech Connect

    Mason, W.E.

    1983-03-01

    A set of finite element codes for the solution of nonlinear, two-dimensional (TACO2D) and three-dimensional (TACO3D) heat transfer problems. Performs linear and nonlinear analyses of both transient and steady state heat transfer problems. Has the capability to handle time or temperature dependent material properties. Materials may be either isotropic or orthotropic. A variety of time and temperature dependent boundary conditions and loadings are available including temperature, flux, convection, radiation, and internal heat generation.

  17. Tomosynthesis imaging with 2D scanning trajectories

    NASA Astrophysics Data System (ADS)

    Khare, Kedar; Claus, Bernhard E. H.; Eberhard, Jeffrey W.

    2011-03-01

    Tomosynthesis imaging in chest radiography provides volumetric information with the potential for improved diagnostic value when compared to the standard AP or LAT projections. In this paper we explore the image quality benefits of 2D scanning trajectories when coupled with advanced image reconstruction approaches. It is intuitively clear that 2D trajectories provide projection data that is more complete in terms of Radon space filling, when compared with conventional tomosynthesis using a linearly scanned source. Incorporating this additional information for obtaining improved image quality is, however, not a straightforward problem. The typical tomosynthesis reconstruction algorithms are based on direct inversion methods e.g. Filtered Backprojection (FBP) or iterative algorithms that are variants of the Algebraic Reconstruction Technique (ART). The FBP approach is fast and provides high frequency details in the image but at the same time introduces streaking artifacts degrading the image quality. The iterative methods can reduce the image artifacts by using image priors but suffer from a slow convergence rate, thereby producing images lacking high frequency details. In this paper we propose using a fast converging optimal gradient iterative scheme that has advantages of both the FBP and iterative methods in that it produces images with high frequency details while reducing the image artifacts. We show that using favorable 2D scanning trajectories along with the proposed reconstruction method has the advantage of providing improved depth information for structures such as the spine and potentially producing images with more isotropic resolution.

  18. MAGNUM-2D computer code: user's guide

    SciTech Connect

    England, R.L.; Kline, N.W.; Ekblad, K.J.; Baca, R.G.

    1985-01-01

    Information relevant to the general use of the MAGNUM-2D computer code is presented. This computer code was developed for the purpose of modeling (i.e., simulating) the thermal and hydraulic conditions in the vicinity of a waste package emplaced in a deep geologic repository. The MAGNUM-2D computer computes (1) the temperature field surrounding the waste package as a function of the heat generation rate of the nuclear waste and thermal properties of the basalt and (2) the hydraulic head distribution and associated groundwater flow fields as a function of the temperature gradients and hydraulic properties of the basalt. MAGNUM-2D is a two-dimensional numerical model for transient or steady-state analysis of coupled heat transfer and groundwater flow in a fractured porous medium. The governing equations consist of a set of coupled, quasi-linear partial differential equations that are solved using a Galerkin finite-element technique. A Newton-Raphson algorithm is embedded in the Galerkin functional to formulate the problem in terms of the incremental changes in the dependent variables. Both triangular and quadrilateral finite elements are used to represent the continuum portions of the spatial domain. Line elements may be used to represent discrete conduits. 18 refs., 4 figs., 1 tab.

  19. Engineering light outcoupling in 2D materials.

    PubMed

    Lien, Der-Hsien; Kang, Jeong Seuk; Amani, Matin; Chen, Kevin; Tosun, Mahmut; Wang, Hsin-Ping; Roy, Tania; Eggleston, Michael S; Wu, Ming C; Dubey, Madan; Lee, Si-Chen; He, Jr-Hau; Javey, Ali

    2015-02-11

    When light is incident on 2D transition metal dichalcogenides (TMDCs), it engages in multiple reflections within underlying substrates, producing interferences that lead to enhancement or attenuation of the incoming and outgoing strength of light. Here, we report a simple method to engineer the light outcoupling in semiconducting TMDCs by modulating their dielectric surroundings. We show that by modulating the thicknesses of underlying substrates and capping layers, the interference caused by substrate can significantly enhance the light absorption and emission of WSe2, resulting in a ∼11 times increase in Raman signal and a ∼30 times increase in the photoluminescence (PL) intensity of WSe2. On the basis of the interference model, we also propose a strategy to control the photonic and optoelectronic properties of thin-layer WSe2. This work demonstrates the utilization of outcoupling engineering in 2D materials and offers a new route toward the realization of novel optoelectronic devices, such as 2D LEDs and solar cells. PMID:25602462

  20. The NASA Library and Researchers at Goddard: A Visitor's Perspective

    ERIC Educational Resources Information Center

    Powell, Jill H.

    2014-01-01

    Jill Powell, engineering librarian from Cornell University, visited the library at NASA Goddard in Greenbelt, Maryland in July 2013, interviewing library staff and selected NASA scientists. She studied the library's digital projects, publications, services, and operations. She also interviewed several NASA scientists on information-seeking…

  1. The time-of-flight system on the Goddard medium energy gamma-ray telescope

    NASA Technical Reports Server (NTRS)

    Ross, R. W.; Chesney, J. R.

    1979-01-01

    A scintillation counter time of flight system, incorporated into the Goddard 50 cm by 50 cm spark chamber gamma ray telescope is described. The system, which utilizes constant fractions timing and particle position compensation and digitizes up to 10 ns time differences to six bit accuracy in less than 500 ns is analyzed. The performance of this system during balloon flight is discussed.

  2. Rocket pioneer Robert Goddard: A micro-biography (pt 3/3)

    NASA Technical Reports Server (NTRS)

    1970-01-01

    Archive footage of Robert Goddard, rocket pioneer of the 1920's and '30's. Ahead of his time, and the first to use liquid propellant. From the 'Moonwalk Series: Episode 1 - 'The Day Before''. A four part documentary series made in the 1970's about the Apollo 11 mission.

  3. Rocket pioneer Robert Goddard: A micro-biography (pt 2/3)

    NASA Technical Reports Server (NTRS)

    1970-01-01

    Archive footage of Robert Goddard, rocket pioneer of the 1920's and '30's. Ahead of his time, and the first to use liquid propellant. From the 'Moonwalk Series: Episode 1 - 'The Day Before''. A four part documentary series made in the 1970's about the Apollo 11 mission.

  4. Rocket pioneer Robert Goddard: A micro-biography (pt 1/3)

    NASA Technical Reports Server (NTRS)

    1970-01-01

    Archive footage of Robert Goddard, rocket pioneer of the 1920's and '30's. Ahead of his time, and the first to use liquid propellant. From the 'Moonwalk Series: Episode 1 - 'The Day Before''. A four part documentary series made in the 1970's about the Apollo 11 mission.

  5. Experimental Use of A Programming Language (APL) at the Goddard Space Flight Center.

    ERIC Educational Resources Information Center

    Creveling, Cyrus J., Ed.

    This document explains A Programming Language (APL) and describes the experiment that the Information Processing Division has undertaken to introduce APL to the Goddard Scientific Community. A brief historical sketch of steps taken to date is included and appendices giving illustrative examples of how APL actually has been used at the Goddard…

  6. Studying Precipitation Processes in WRF with Goddard Bulk Microphysics in Comparison with Other Microphysical Schemes

    NASA Technical Reports Server (NTRS)

    Tao, W.K.; Shi, J.J.; Braun, S.; Simpson, J.; Chen, S.S.; Lang, S.; Hong, S.Y.; Thompson, G.; Peters-Lidard, C.

    2009-01-01

    A Goddard bulk microphysical parameterization is implemented into the Weather Research and Forecasting (WRF) model. This bulk microphysical scheme has three different options, 2ICE (cloud ice & snow), 3ICE-graupel (cloud ice, snow & graupel) and 3ICE-hail (cloud ice, snow & hail). High-resolution model simulations are conducted to examine the impact of microphysical schemes on different weather events: a midlatitude linear convective system and an Atlantic hurricane. The results suggest that microphysics has a major impact on the organization and precipitation processes associated with a summer midlatitude convective line system. The Goddard 3ICE scheme with the cloud ice-snow-hail configuration agreed better with observations ill of rainfall intensity and having a narrow convective line than did simulations with the cloud ice-snow-graupel and cloud ice-snow (i.e., 2ICE) configurations. This is because the Goddard 3ICE-hail configuration has denser precipitating ice particles (hail) with very fast fall speeds (over 10 m/s) For an Atlantic hurricane case, the Goddard microphysical scheme (with 3ICE-hail, 3ICE-graupel and 2ICE configurations) had no significant impact on the track forecast but did affect the intensity slightly. The Goddard scheme is also compared with WRF's three other 3ICE bulk microphysical schemes: WSM6, Purdue-Lin and Thompson. For the summer midlatitude convective line system, all of the schemes resulted in simulated precipitation events that were elongated in southwest-northeast direction in qualitative agreement with the observed feature. However, the Goddard 3ICE-hail and Thompson schemes were closest to the observed rainfall intensities although the Goddard scheme simulated more heavy rainfall (over 48 mm/h). For the Atlantic hurricane case, none of the schemes had a significant impact on the track forecast; however, the simulated intensity using the Purdue-Lin scheme was much stronger than the other schemes. The vertical distributions of

  7. 2D superconductivity by ionic gating

    NASA Astrophysics Data System (ADS)

    Iwasa, Yoshi

    2D superconductivity is attracting a renewed interest due to the discoveries of new highly crystalline 2D superconductors in the past decade. Superconductivity at the oxide interfaces triggered by LaAlO3/SrTiO3 has become one of the promising routes for creation of new 2D superconductors. Also, the MBE grown metallic monolayers including FeSe are also offering a new platform of 2D superconductors. In the last two years, there appear a variety of monolayer/bilayer superconductors fabricated by CVD or mechanical exfoliation. Among these, electric field induced superconductivity by electric double layer transistor (EDLT) is a unique platform of 2D superconductivity, because of its ability of high density charge accumulation, and also because of the versatility in terms of materials, stemming from oxides to organics and layered chalcogenides. In this presentation, the following issues of electric filed induced superconductivity will be addressed; (1) Tunable carrier density, (2) Weak pinning, (3) Absence of inversion symmetry. (1) Since the sheet carrier density is quasi-continuously tunable from 0 to the order of 1014 cm-2, one is able to establish an electronic phase diagram of superconductivity, which will be compared with that of bulk superconductors. (2) The thickness of superconductivity can be estimated as 2 - 10 nm, dependent on materials, and is much smaller than the in-plane coherence length. Such a thin but low resistance at normal state results in extremely weak pinning beyond the dirty Boson model in the amorphous metallic films. (3) Due to the electric filed, the inversion symmetry is inherently broken in EDLT. This feature appears in the enhancement of Pauli limit of the upper critical field for the in-plane magnetic fields. In transition metal dichalcogenide with a substantial spin-orbit interactions, we were able to confirm the stabilization of Cooper pair due to its spin-valley locking. This work has been supported by Grant-in-Aid for Specially

  8. Cloud Condensation Nuclei in Cumulus Humilis — selected Case Study During the CHAPS Campaign

    SciTech Connect

    Yu, X.; Lee, Y.; Berg, L.; Berkowitz, C.; Alexander, L.; Laskin, A.; Ogren, J.; Andrews, E.

    2010-03-15

    The Cumulus Humilis Aerosol Processing Study (CHAPS) provided a unique opportunity to study aerosol and cloud processing. Clouds play an active role in the processing and cycling of atmospheric constituents. Gases and particles can partition to cloud droplets by absorption and condensation as well as activation and impact scavenging. The U.S. Department of Energy (DOE) G-1 aircraft was used as one of the main platforms in CHAPS. Flight tracks were designed and implemented to characterize freshly emitted aerosols at cloud top and cloud base as well as within the cloud, i.e., cumulus humilis (or fair-weather cumulus), in the vicinity of Oklahoma City. Measurements of interstitial aerosols and residuals of activated condensation cloud nuclei were conducted simultaneously. The interstitial aerosols were measured downstream of an isokinetic inlet, and the activated particles downstream of a counter-flow virtual impactor (CVI). The sampling line to the Aerodyne Aerosol Mass Spectrometer (AMS) was switched between the isokinetic inlet and the CVI to allow characterization of non-activated interstitial particles outside of clouds in contrast to particles activated in clouds. Trace gases including ozone, carbon monoxide, sulfur dioxide, and a series of volatile organic compounds (VOCs) were also measured, as were key meteorological state parameters including liquid water content, cloud drop size, and dew point. We will report on the CCN properties in cumulus humilis. Several approaches will be taken. The first is single-particle analysis of particles collected by the Time-Resolved Aerosol Sampler (TRAC) by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) coupled with energy disperse X-ray spectroscopy (EDX). Specifically, we examine differences between activated and interstitial ones, such as differences in chemical composition and morphology. The second analysis will link in situ measurements by AMS and PTRMS with the observations by TRAC. For

  9. Performance tuning Weather Research and Forecasting (WRF) Goddard longwave radiative transfer scheme on Intel Xeon Phi

    NASA Astrophysics Data System (ADS)

    Mielikainen, Jarno; Huang, Bormin; Huang, Allen H.

    2015-10-01

    Next-generation mesoscale numerical weather prediction system, the Weather Research and Forecasting (WRF) model, is a designed for dual use for forecasting and research. WRF offers multiple physics options that can be combined in any way. One of the physics options is radiance computation. The major source for energy for the earth's climate is solar radiation. Thus, it is imperative to accurately model horizontal and vertical distribution of the heating. Goddard solar radiative transfer model includes the absorption duo to water vapor,ozone, ozygen, carbon dioxide, clouds and aerosols. The model computes the interactions among the absorption and scattering by clouds, aerosols, molecules and surface. Finally, fluxes are integrated over the entire longwave spectrum.In this paper, we present our results of optimizing the Goddard longwave radiative transfer scheme on Intel Many Integrated Core Architecture (MIC) hardware. The Intel Xeon Phi coprocessor is the first product based on Intel MIC architecture, and it consists of up to 61 cores connected by a high performance on-die bidirectional interconnect. The coprocessor supports all important Intel development tools. Thus, the development environment is familiar one to a vast number of CPU developers. Although, getting a maximum performance out of MICs will require using some novel optimization techniques. Those optimization techniques are discusses in this paper. The optimizations improved the performance of the original Goddard longwave radiative transfer scheme on Xeon Phi 7120P by a factor of 2.2x. Furthermore, the same optimizations improved the performance of the Goddard longwave radiative transfer scheme on a dual socket configuration of eight core Intel Xeon E5-2670 CPUs by a factor of 2.1x compared to the original Goddard longwave radiative transfer scheme code.

  10. GBL-2D Version 1.0: a 2D geometry boolean library.

    SciTech Connect

    McBride, Cory L. (Elemental Technologies, American Fort, UT); Schmidt, Rodney Cannon; Yarberry, Victor R.; Meyers, Ray J.

    2006-11-01

    This report describes version 1.0 of GBL-2D, a geometric Boolean library for 2D objects. The library is written in C++ and consists of a set of classes and routines. The classes primarily represent geometric data and relationships. Classes are provided for 2D points, lines, arcs, edge uses, loops, surfaces and mask sets. The routines contain algorithms for geometric Boolean operations and utility functions. Routines are provided that incorporate the Boolean operations: Union(OR), XOR, Intersection and Difference. A variety of additional analytical geometry routines and routines for importing and exporting the data in various file formats are also provided. The GBL-2D library was originally developed as a geometric modeling engine for use with a separate software tool, called SummitView [1], that manipulates the 2D mask sets created by designers of Micro-Electro-Mechanical Systems (MEMS). However, many other practical applications for this type of software can be envisioned because the need to perform 2D Boolean operations can arise in many contexts.

  11. Role of Fas-mediated apoptosis and follicle-stimulating hormone on the developmental capacity of bovine cumulus oocyte complexes in vitro.

    PubMed

    Rubio Pomar, Francisco J; Roelen, Bernard A J; Slot, Karin A; van Tol, Helena T A; Colenbrander, Ben; Teerds, Katja J

    2004-09-01

    Follicular atresia is believed to be largely regulated by apoptosis. To further understand how apoptosis can affect cumulus cells and oocytes we have evaluated the incidence and regulation of apoptosis affecting bovine cumulus oocyte complexes in vitro. Expression of components of the Fas signaling pathway was studied in both oocytes and cumulus cells by polymerase chain reaction after reverse transcription, immunoblotting, and indirect immunofluorescence. Furthermore, the Fas signaling pathway was activated in cumulus oocyte complexes with an agonistic anti-Fas antibody during in vitro maturation in the presence or absence of FSH. Viability and incidence of apoptosis in cumulus cells were evaluated by assessing membrane integrity and nuclear morphology. Oocyte nuclear maturation was also analyzed, as well as cleavage rates, blastocyst formation rates, and blastocyst quality, following in vitro fertilization. Fas mRNA and protein were expressed both in oocytes and cumulus cells. FasL protein was found in cumulus cells but could not be detected in oocytes, despite its mRNA expression. Both activation of the Fas pathway and presence of FSH during in vitro maturation increased the incidence of apoptosis in cumulus cells, affecting predominantly the middle and peripheral regions of the cumulus. The observed increase, however, had no effect on the developmental competence of the oocytes. PMID:15128594

  12. Interparticle Attraction in 2D Complex Plasmas

    NASA Astrophysics Data System (ADS)

    Kompaneets, Roman; Morfill, Gregor E.; Ivlev, Alexei V.

    2016-03-01

    Complex (dusty) plasmas allow experimental studies of various physical processes occurring in classical liquids and solids by directly observing individual microparticles. A major problem is that the interaction between microparticles is generally not molecularlike. In this Letter, we propose how to achieve a molecularlike interaction potential in laboratory 2D complex plasmas. We argue that this principal aim can be achieved by using relatively small microparticles and properly adjusting discharge parameters. If experimentally confirmed, this will make it possible to employ complex plasmas as a model system with an interaction potential resembling that of conventional liquids.

  13. Periodically sheared 2D Yukawa systems

    SciTech Connect

    Kovács, Anikó Zsuzsa; Hartmann, Peter; Donkó, Zoltán

    2015-10-15

    We present non-equilibrium molecular dynamics simulation studies on the dynamic (complex) shear viscosity of a 2D Yukawa system. We have identified a non-monotonic frequency dependence of the viscosity at high frequencies and shear rates, an energy absorption maximum (local resonance) at the Einstein frequency of the system at medium shear rates, an enhanced collective wave activity, when the excitation is near the plateau frequency of the longitudinal wave dispersion, and the emergence of significant configurational anisotropy at small frequencies and high shear rates.

  14. ENERGY LANDSCAPE OF 2D FLUID FORMS

    SciTech Connect

    Y. JIANG; ET AL

    2000-04-01

    The equilibrium states of 2D non-coarsening fluid foams, which consist of bubbles with fixed areas, correspond to local minima of the total perimeter. (1) The authors find an approximate value of the global minimum, and determine directly from an image how far a foam is from its ground state. (2) For (small) area disorder, small bubbles tend to sort inwards and large bubbles outwards. (3) Topological charges of the same sign repel while charges of opposite sign attract. (4) They discuss boundary conditions and the uniqueness of the pattern for fixed topology.

  15. A scalable 2-D parallel sparse solver

    SciTech Connect

    Kothari, S.C.; Mitra, S.

    1995-12-01

    Scalability beyond a small number of processors, typically 32 or less, is known to be a problem for existing parallel general sparse (PGS) direct solvers. This paper presents a parallel general sparse PGS direct solver for general sparse linear systems on distributed memory machines. The algorithm is based on the well-known sequential sparse algorithm Y12M. To achieve efficient parallelization, a 2-D scattered decomposition of the sparse matrix is used. The proposed algorithm is more scalable than existing parallel sparse direct solvers. Its scalability is evaluated on a 256 processor nCUBE2s machine using Boeing/Harwell benchmark matrices.

  16. 2D stepping drive for hyperspectral systems

    NASA Astrophysics Data System (ADS)

    Endrödy, Csaba; Mehner, Hannes; Grewe, Adrian; Sinzinger, Stefan; Hoffmann, Martin

    2015-07-01

    We present the design, fabrication and characterization of a compact 2D stepping microdrive for pinhole array positioning. The miniaturized solution enables a highly integrated compact hyperspectral imaging system. Based on the geometry of the pinhole array, an inch-worm drive with electrostatic actuators was designed resulting in a compact (1 cm2) positioning system featuring a step size of about 15 µm in a 170 µm displacement range. The high payload (20 mg) as required for the pinhole array and the compact system design exceed the known electrostatic inch-worm-based microdrives.

  17. New data and capabilities in the NASA Goddard Hurricane Data Portal

    NASA Astrophysics Data System (ADS)

    Liu, Z.; Leptoukh, G.; Ostrenga, D.; Savtchenko, C.; Kempler, S.

    2007-12-01

    .ecs.nasa.gov/OPS/mirador/) is another in-house developed tool that offers a simplified interface for searching, browsing, and ordering Earth science data at NASA GES DICS. Users can do event based (e.g., entering a hurricane name) search and order data. · Hurricane viewer: provides users with a view of the hurricane track that overlays TRMM 3-hourly precipitation data. The interface provides users with the storm track, wind speeds, pressure, intensity and view of the data of the lifespan of the storm in an animated series. The Hurricane Viewer will be enhanced to allow users to select from multiple data parameters to view in the background of the track. · There are a number of other resources for hurricane related activities at the DISC, such as, viewing and exploring NASA 2-D and 3-D data (TRMM, CloudSat, AIRS, etc.) via Google Earth. Details and examples will be presented.

  18. WFR-2D: an analytical model for PWAS-generated 2D ultrasonic guided wave propagation

    NASA Astrophysics Data System (ADS)

    Shen, Yanfeng; Giurgiutiu, Victor

    2014-03-01

    This paper presents WaveFormRevealer 2-D (WFR-2D), an analytical predictive tool for the simulation of 2-D ultrasonic guided wave propagation and interaction with damage. The design of structural health monitoring (SHM) systems and self-aware smart structures requires the exploration of a wide range of parameters to achieve best detection and quantification of certain types of damage. Such need for parameter exploration on sensor dimension, location, guided wave characteristics (mode type, frequency, wavelength, etc.) can be best satisfied with analytical models which are fast and efficient. The analytical model was constructed based on the exact 2-D Lamb wave solution using Bessel and Hankel functions. Damage effects were inserted in the model by considering the damage as a secondary wave source with complex-valued directivity scattering coefficients containing both amplitude and phase information from wave-damage interaction. The analytical procedure was coded with MATLAB, and a predictive simulation tool called WaveFormRevealer 2-D was developed. The wave-damage interaction coefficients (WDICs) were extracted from harmonic analysis of local finite element model (FEM) with artificial non-reflective boundaries (NRB). The WFR-2D analytical simulation results were compared and verified with full scale multiphysics finite element models and experiments with scanning laser vibrometer. First, Lamb wave propagation in a pristine aluminum plate was simulated with WFR-2D, compared with finite element results, and verified by experiments. Then, an inhomogeneity was machined into the plate to represent damage. Analytical modeling was carried out, and verified by finite element simulation and experiments. This paper finishes with conclusions and suggestions for future work.

  19. Microwave Assisted 2D Materials Exfoliation

    NASA Astrophysics Data System (ADS)

    Wang, Yanbin

    Two-dimensional materials have emerged as extremely important materials with applications ranging from energy and environmental science to electronics and biology. Here we report our discovery of a universal, ultrafast, green, solvo-thermal technology for producing excellent-quality, few-layered nanosheets in liquid phase from well-known 2D materials such as such hexagonal boron nitride (h-BN), graphite, and MoS2. We start by mixing the uniform bulk-layered material with a common organic solvent that matches its surface energy to reduce the van der Waals attractive interactions between the layers; next, the solutions are heated in a commercial microwave oven to overcome the energy barrier between bulk and few-layers states. We discovered the minutes-long rapid exfoliation process is highly temperature dependent, which requires precise thermal management to obtain high-quality inks. We hypothesize a possible mechanism of this proposed solvo-thermal process; our theory confirms the basis of this novel technique for exfoliation of high-quality, layered 2D materials by using an as yet unknown role of the solvent.

  20. Photocurrent spectroscopy of 2D materials

    NASA Astrophysics Data System (ADS)

    Cobden, David

    Confocal photocurrent measurements provide a powerful means of studying many aspects of the optoelectronic and electrical properties of a 2D device or material. At a diffraction-limited point they can provide a detailed absorption spectrum, and they can probe local symmetry, ultrafast relaxation rates and processes, electron-electron interaction strengths, and transport coefficients. We illustrate this with several examples, once being the photo-Nernst effect. In gapless 2D materials, such as graphene, in a perpendicular magnetic field a photocurrent antisymmetric in the field is generated near to the free edges, with opposite sign at opposite edges. Its origin is the transverse thermoelectric current associated with the laser-induced electron temperature gradient. This effect provides an unambiguous demonstration of the Shockley-Ramo nature of long-range photocurrent generation in gapless materials. It also provides a means of investigating quasiparticle properties. For example, in the case of graphene on hBN, it can be used to probe the Lifshitz transition that occurs due to the minibands formed by the Moire superlattice. We also observe and discuss photocurrent generated in other semimetallic (WTe2) and semiconducting (WSe2) monolayers. Work supported by DoE BES and NSF EFRI grants.

  1. Multienzyme Inkjet Printed 2D Arrays.

    PubMed

    Gdor, Efrat; Shemesh, Shay; Magdassi, Shlomo; Mandler, Daniel

    2015-08-19

    The use of printing to produce 2D arrays is well established, and should be relatively facile to adapt for the purpose of printing biomaterials; however, very few studies have been published using enzyme solutions as inks. Among the printing technologies, inkjet printing is highly suitable for printing biomaterials and specifically enzymes, as it offers many advantages. Formulation of the inkjet inks is relatively simple and can be adjusted to a variety of biomaterials, while providing nonharmful environment to the enzymes. Here we demonstrate the applicability of inkjet printing for patterning multiple enzymes in a predefined array in a very straightforward, noncontact method. Specifically, various arrays of the enzymes glucose oxidase (GOx), invertase (INV) and horseradish peroxidase (HP) were printed on aminated glass surfaces, followed by immobilization using glutardialdehyde after printing. Scanning electrochemical microscopy (SECM) was used for imaging the printed patterns and to ascertain the enzyme activity. The successful formation of 2D arrays consisting of enzymes was explored as a means of developing the first surface confined enzyme based logic gates. Principally, XOR and AND gates, each consisting of two enzymes as the Boolean operators, were assembled, and their operation was studied by SECM. PMID:26214072

  2. 2-D or not 2-D, that is the question: A Northern California test

    SciTech Connect

    Mayeda, K; Malagnini, L; Phillips, W S; Walter, W R; Dreger, D

    2005-06-06

    Reliable estimates of the seismic source spectrum are necessary for accurate magnitude, yield, and energy estimation. In particular, how seismic radiated energy scales with increasing earthquake size has been the focus of recent debate within the community and has direct implications on earthquake source physics studies as well as hazard mitigation. The 1-D coda methodology of Mayeda et al. has provided the lowest variance estimate of the source spectrum when compared against traditional approaches that use direct S-waves, thus making it ideal for networks that have sparse station distribution. The 1-D coda methodology has been mostly confined to regions of approximately uniform complexity. For larger, more geophysically complicated regions, 2-D path corrections may be required. The complicated tectonics of the northern California region coupled with high quality broadband seismic data provides for an ideal ''apples-to-apples'' test of 1-D and 2-D path assumptions on direct waves and their coda. Using the same station and event distribution, we compared 1-D and 2-D path corrections and observed the following results: (1) 1-D coda results reduced the amplitude variance relative to direct S-waves by roughly a factor of 8 (800%); (2) Applying a 2-D correction to the coda resulted in up to 40% variance reduction from the 1-D coda results; (3) 2-D direct S-wave results, though better than 1-D direct waves, were significantly worse than the 1-D coda. We found that coda-based moment-rate source spectra derived from the 2-D approach were essentially identical to those from the 1-D approach for frequencies less than {approx}0.7-Hz, however for the high frequencies (0.7{le} f {le} 8.0-Hz), the 2-D approach resulted in inter-station scatter that was generally 10-30% smaller. For complex regions where data are plentiful, a 2-D approach can significantly improve upon the simple 1-D assumption. In regions where only 1-D coda correction is available it is still preferable over 2

  3. Apoptotic index within cumulus cells is a questionable marker of meiotic competence of bovine oocytes matured in vitro.

    PubMed

    Warzych, Ewelina; Pers-Kamczyc, Emilia; Krzywak, Anna; Dudzińska, Stanisława; Lechniak, Dorota

    2013-03-01

    Information gained from most human studies indicate a negative correlation between the apoptotic index (AI) in cumulus cells (CC) and the quality of the corresponding oocytes. However, results obtained in other species are not so consistent. The rate of apoptosis-free COCs (cumulus oocytes complexes) subjected to IVM (in vitro maturation) also varies among studies. The aim of the present study was to investigate whether the AI in cumulus cells of post-IVM COCs is related to the morphology of pre-IVM COCs and to meiotic competence of bovine oocytes. COCs of known morphology (four grade scale) obtained from individual follicles were matured in a well-in-drop system. After IVM, the external layers of CC of each COC were analyzed by TUNEL. In order to determine the meiotic stage, oocytes were stained with DAPI. It was found that 25.6% of bovine COCs contained apoptosis-free cumulus cells. Moreover, the majority of COCs with apoptotic cells were characterized by apoptotic index lower than 15%. The level of apoptosis in CC was related neither to COC morphology nor to the oocyte meiotic stage. It is suggested that the extent of apoptosis in cumulus cells is not a reliable quality marker of the corresponding oocyte after IVM. PMID:23522075

  4. Gravity model and structural implications of the Goddard Pendant, Sierra Nevada, California.

    USGS Publications Warehouse

    du Bray, E.A.; Oliver, H.W.

    1981-01-01

    A subsurface model for the Goddard pendant is constructed from a residual gravity high of about 7mGal over the pendant. The model, which is the simplest and most geologically reasonable possibility, shows a metamorphic block that tapers with depth and extends about 3.5km below the surface. The structures in the Goddard pendant are similar in style and orientation to those in other Sierra Nevada pendants, indicating that the country rock was neither deformed nor rotated during pluton emplacement. Consequently, emplacement must have been a passive rather than a forceful process. The pendant itself represents a piece of country rock trapped between plutons which are dome shaped in cross section. -Authors

  5. Stray Light Suppression in the Goddard IRAM 2-Millimeter Observer (GISMO)

    NASA Technical Reports Server (NTRS)

    Sharp, E. H.; Benford, D. J.; Fixsen, D. J.; Moseley, S. H.; Staguhn, J. G.; Wollack, E. J.

    2012-01-01

    The Goddard-IRAM Superconducting 2 Millimeter Observer (GISMO) is an 8xl6 Transition Edge Sensor (TES) array of bolometers built as a pathfinder for TES detector development efforts at NASA Goddard Space Flight Center. GISMO has been used annually at the Institut de Radioastronomie Millimetrique (IRAM) 30 meter telescope since 2007 under engineering time and was opened in the spring of 2012 to the general astronomical community. The spring deployment provided an opportunity to modify elements of the room temperature optics before moving the instrument to its new permanent position in the telescope receiver cabin. This allowed for the possibility to extend the cryostat, introduce improved cold baffling and thus further optimize the stray light performance for final astronomical use of the instrument, which has been completed and validated. We will demonstrate and discuss several of the methods used to quantify and limit the influence of stray light in the GISMO camera.

  6. Tropospheric Wind Measurements Obtained with the Goddard Lidar Observatory for Winds (GLOW): Validation and Performance

    NASA Technical Reports Server (NTRS)

    Gentry, Bruce M.; Einaudi, Franco (Technical Monitor)

    2001-01-01

    The Goddard Lidar Observatory for Winds (GLOW) is a mobile Doppler lidar system which uses direct detection Doppler lidar techniques to measure wind profiles from the surface into the lower stratosphere. GLOW is intended to be used as a field deployable system for studying atmospheric dynamics and transport and can also serve as a testbed to evaluate candidate technologies developed for use in future spaceborne systems. In September of 2000 GLOW participated in a three week intercomparison experiment at the GroundWinds facility in North Glen, NE. More than 50 hours of line-of-sight wind profile data was obtained in a wide variety of conditions including both day and night operation. Typical clear air lidar wind profiles extended to altitudes of 20 km with a 1 Ian vertical resolution and I minute averaging. A description of the mobile system is presented along with the examples of lidar wind profiles obtained with the Goddard system during the New Hampshire experiment.

  7. Tropospheric Wind Measurements Obtained with the Goddard Lidar Observatory for Winds (GLOW): Validation and Performance

    NASA Technical Reports Server (NTRS)

    Gentry, Bruce M.; Chen, Huai-Lin; Einaudi, Franco (Technical Monitor)

    2001-01-01

    The Goddard Lidar Observatory for Winds (GLOW) is a mobile Doppler lidar system which uses direct detection Doppler lidar techniques to measure wind profiles from the surface into the lower stratosphere. GLOW is intended to be used as a field deployable system for studying atmospheric dynamics and transport and can also serve as a testbed to evaluate candidate technologies developed for use in future spaceborne systems. In September of 2000 GLOW participated in a three week intercomparison experiment at the GroundWinds facility in North Glen, NH. More than 50 hours of line-of-sight wind profile data were obtained in a wide variety of conditions including both day and night operation. Typical clear air lidar wind profiles extended to altitudes of 20 kin with a 1 km vertical resolution and 1 minute averaging. A description of the mobile system is presented along with the examples of lidar wind profiles obtained with the Goddard system during the New Hampshire experiment.

  8. Goddard's New Approach to Information Technology: The Information Systems Center an Overview

    NASA Technical Reports Server (NTRS)

    Kea, Howard E.

    1994-01-01

    The Information Center (ISC) at Goddard was created as part of the Goddard reorganization and was located within the Applied Engineering and Technology (AET) Directorate. The creation of ISC was to: (1) focus expertise and leadership in information system development; (2) Promote organizational collaboration, partnerships, and resource sharing; (3) Stimulate design/development of seamless end-to-end flight and ground systems; (4) Enable flexibility to effectively support many simultaneous projects by improved access to critical mass of discipline expertise; (5) Enhance career growth and opportunities including multi-disciplinary opportunities; and (6) to improve communications among information system professionals. This paper presents a general overview of the Information Systems Center as well as the role of the Software Engineering Laboratory within the center.

  9. Numerical Evaluation of 2D Ground States

    NASA Astrophysics Data System (ADS)

    Kolkovska, Natalia

    2016-02-01

    A ground state is defined as the positive radial solution of the multidimensional nonlinear problem \\varepsilon propto k_ bot 1 - ξ with the function f being either f(u) =a|u|p-1u or f(u) =a|u|pu+b|u|2pu. The numerical evaluation of ground states is based on the shooting method applied to an equivalent dynamical system. A combination of fourth order Runge-Kutta method and Hermite extrapolation formula is applied to solving the resulting initial value problem. The efficiency of this procedure is demonstrated in the 1D case, where the maximal difference between the exact and numerical solution is ≈ 10-11 for a discretization step 0:00025. As a major application, we evaluate numerically the critical energy constant. This constant is defined as a functional of the ground state and is used in the study of the 2D Boussinesq equations.

  10. Canard configured aircraft with 2-D nozzle

    NASA Technical Reports Server (NTRS)

    Child, R. D.; Henderson, W. P.

    1978-01-01

    A closely-coupled canard fighter with vectorable two-dimensional nozzle was designed for enhanced transonic maneuvering. The HiMAT maneuver goal of a sustained 8g turn at a free-stream Mach number of 0.9 and 30,000 feet was the primary design consideration. The aerodynamic design process was initiated with a linear theory optimization minimizing the zero percent suction drag including jet effects and refined with three-dimensional nonlinear potential flow techniques. Allowances were made for mutual interference and viscous effects. The design process to arrive at the resultant configuration is described, and the design of a powered 2-D nozzle model to be tested in the LRC 16-foot Propulsion Wind Tunnel is shown.

  11. 2D Electrostatic Actuation of Microshutter Arrays

    NASA Technical Reports Server (NTRS)

    Burns, Devin E.; Oh, Lance H.; Li, Mary J.; Jones, Justin S.; Kelly, Daniel P.; Zheng, Yun; Kutyrev, Alexander S.; Moseley, Samuel H.

    2015-01-01

    An electrostatically actuated microshutter array consisting of rotational microshutters (shutters that rotate about a torsion bar) were designed and fabricated through the use of models and experiments. Design iterations focused on minimizing the torsional stiffness of the microshutters, while maintaining their structural integrity. Mechanical and electromechanical test systems were constructed to measure the static and dynamic behavior of the microshutters. The torsional stiffness was reduced by a factor of four over initial designs without sacrificing durability. Analysis of the resonant behavior of the microshutter arrays demonstrates that the first resonant mode is a torsional mode occurring around 3000 Hz. At low vacuum pressures, this resonant mode can be used to significantly reduce the drive voltage necessary for actuation requiring as little as 25V. 2D electrostatic latching and addressing was demonstrated using both a resonant and pulsed addressing scheme.

  12. 2D Electrostatic Actuation of Microshutter Arrays

    NASA Technical Reports Server (NTRS)

    Burns, Devin E.; Oh, Lance H.; Li, Mary J.; Kelly, Daniel P.; Kutyrev, Alexander S.; Moseley, Samuel H.

    2015-01-01

    Electrostatically actuated microshutter arrays consisting of rotational microshutters (shutters that rotate about a torsion bar) were designed and fabricated through the use of models and experiments. Design iterations focused on minimizing the torsional stiffness of the microshutters, while maintaining their structural integrity. Mechanical and electromechanical test systems were constructed to measure the static and dynamic behavior of the microshutters. The torsional stiffness was reduced by a factor of four over initial designs without sacrificing durability. Analysis of the resonant behavior of the microshutters demonstrates that the first resonant mode is a torsional mode occurring around 3000 Hz. At low vacuum pressures, this resonant mode can be used to significantly reduce the drive voltage necessary for actuation requiring as little as 25V. 2D electrostatic latching and addressing was demonstrated using both a resonant and pulsed addressing scheme.

  13. Graphene suspensions for 2D printing

    NASA Astrophysics Data System (ADS)

    Soots, R. A.; Yakimchuk, E. A.; Nebogatikova, N. A.; Kotin, I. A.; Antonova, I. V.

    2016-04-01

    It is shown that, by processing a graphite suspension in ethanol or water by ultrasound and centrifuging, it is possible to obtain particles with thicknesses within 1-6 nm and, in the most interesting cases, 1-1.5 nm. Analogous treatment of a graphite suspension in organic solvent yields eventually thicker particles (up to 6-10 nm thick) even upon long-term treatment. Using the proposed ink based on graphene and aqueous ethanol with ethylcellulose and terpineol additives for 2D printing, thin (~5 nm thick) films with sheet resistance upon annealing ~30 MΩ/□ were obtained. With the ink based on aqueous graphene suspension, the sheet resistance was ~5-12 kΩ/□ for 6- to 15-nm-thick layers with a carrier mobility of ~30-50 cm2/(V s).

  14. Expression, regulation, and function of progesterone receptors in bovine cumulus oocyte complexes during in vitro maturation.

    PubMed

    Aparicio, I M; Garcia-Herreros, M; O'Shea, L C; Hensey, C; Lonergan, P; Fair, T

    2011-05-01

    Progesterone (P4) exerts its effects by binding to specific genomic (nPR-A/B) and non-genomic (mPRalpha/beta, PGRMC1/2) receptors. P4 has a role in the regulation of the ovulatory cycle, but its participation in oocyte maturation in mammals has not yet been clarified. Therefore, the aim of the present study was to characterize the protein expression of P4 receptors (PRs) in bovine oocytes and cumulus cells during in vitro maturation (IVM) and to study the effect of P4 and its receptors on oocyte developmental competence. Cumulus-oocyte complexes (COCs) were subjected to IVM, in vitro fertilization, and in vitro culture. IVM was performed for 24 h in the presence or absence of P4, luteinizing hormone (LH), follicle-stimulating hormone (FSH), trilostane, promegestone (R5020), mifepristone (RU 486), or antibodies against mPRalpha or mPRbeta. Protein expression of PRs was studied by Western blotting and immunofluorescence. The results demonstrate the presence of both genomic and nongenomic PRs in bovine COCs. The dynamic changes observed in the protein expression of PRs following IVM or in response to supplementation with LH, FSH, or P4 suggest an important role during bovine oocyte maturation. Inhibition of P4 synthesis by cumulus cells or blocking of nPR and mPR alpha activity produced a decrease in bovine embryo development, indicating that P4 intracellular signaling is mediated by its interaction with nuclear and membrane PRs and is important for oocyte developmental competence. PMID:21228216

  15. Numerical Simulation of Chennai Heavy Rainfall Using MM5 Mesoscale Model with Different Cumulus Parameterization Schemes

    NASA Astrophysics Data System (ADS)

    Litta, A. J.; Chakrapani, B.; Mohankumar, K.

    2007-07-01

    Heavy rainfall events become significant in human affairs when they are combined with hydrological elements. The problem of forecasting heavy precipitation is especially difficult since it involves making a quantitative precipitation forecast, a problem well recognized as challenging. Chennai (13.04°N and 80.17°E) faced incessant and heavy rain about 27 cm in 24 hours up to 8.30 a.m on 27th October 2005 completely threw life out of gear. This torrential rain caused by deep depression which lay 150km east of Chennai city in Bay of Bengal intensified and moved west north-west direction and crossed north Tamil Nadu and south Andhra Pradesh coast on 28th morning. In the present study, we investigate the predictability of the MM5 mesoscale model using different cumulus parameterization schemes for the heavy rainfall event over Chennai. MM5 Version 3.7 (PSU/NCAR) is run with two-way triply nested grids using Lambert Conformal Coordinates (LCC) with a nest ratio of 3:1 and 23 vertical layers. Grid sizes of 45, 15 and 5 km are used for domains 1, 2 and 3 respectively. The cumulus parameterization schemes used in this study are Anthes-Kuo scheme (AK), the Betts-Miller scheme (BM), the Grell scheme (GR) and the Kain-Fritsch scheme (KF). The present study shows that the prediction of heavy rainfall is sensitive to cumulus parameterization schemes. In the time series of rainfall, Grell scheme is in good agreement with observation. The ideal combination of the nesting domains, horizontal resolution and cloud parameterization is able to simulate the heavy rainfall event both qualitatively and quantitatively.

  16. Developmental competence in oocytes and cumulus cells: candidate genes and networks.

    PubMed

    O'Shea, Lynne C; Mehta, Jai; Lonergan, Patrick; Hensey, Carmel; Fair, Trudee

    2012-04-01

    Common aspects of infertility can be seen across several species. In humans, dairy cows, and mares there is only a 25-35% chance of producing a live offspring after a single insemination, whether natural or artificial. Oocyte quality and subsequent embryo development can be affected by factors such as nutrition, hormonal regulation, and environmental influence. The objective of this study was to identify genes expressed in oocytes and/or cumulus cells, across a diverse range of species, which may be linked to the ability an oocyte has to develop following fertilization. Performing a meta-analysis on previously published microarray data on various models of oocyte and embryo quality allowed for the identification of 56 candidate genes associated with oocyte quality across several species, 4 of which were identified in the cumulus cells that surround the oocyte. Twenty-one potential biomarkers were associated with increased competence and 35 potential biomarkers were associated with decreased competence. The upregulation of Metap2, and the decrease of multiple genes linked to mRNA and protein synthesis in models of competence, highlights the importance of de novo protein synthesis and its regulation for successful oocyte maturation and subsequent development. The negative regulation of Wnt signaling has emerged in human, monkey, bovine, and mouse models of oocyte competence. Atrx expression was linked to decreased competence in both oocytes and cumulus cells. Biological networks and transcription factor regulation associated with increased and decreased competence were also identified. These genes could potentially act as biomarkers of oocyte quality or as pharmacological targets for manipulation in order to improve oocyte developmental potential. PMID:22313243

  17. Ejaculated Mouse Sperm Enter Cumulus-Oocyte Complexes More Efficiently In Vitro than Epididymal Sperm

    PubMed Central

    Suarez, Susan S.

    2015-01-01

    The mouse is an established and popular animal model for studying reproductive biology. Epididymal mouse sperm, which lack exposure to secretions of male accessory glands and do not precisely represent ejaculated sperm for the study of sperm functions, have been almost exclusively used in studies. We compared ejaculated and epididymal sperm in an in vitro fertilization setting to examine whether ejaculated sperm enter cumulus-oocyte complexes more efficiently. In order to prepare sperm for fertilization, they were incubated under capacitating conditions. At the outset of incubation, ejaculated sperm stuck to the glass surfaces of slides and the incidences of sticking decreased with time; whereas, very few epididymal sperm stuck to glass at any time point, indicating differences in surface charge. At the end of the capacitating incubation, when sperm were added to cumulus-oocyte complexes, the form of flagellar movement differed dramatically; specifically, ejaculated sperm predominantly exhibited increased bending on one side of the flagellum (a process termed pro-hook hyperactivation), while epididymal sperm equally exhibited increased bending on one or the other side of the flagellum (pro-hook or anti-hook hyperactivation). This indicates that accessory sex gland secretions might have modified Ca2+ signaling activities in sperm, because the two forms of hyperactivation are reported to be triggered by different Ca2+ signaling patterns. Lastly, over time, more ejaculated than epididymal sperm entered the cumulus oocyte complexes. We concluded that modification of sperm by male accessory gland secretions affects the behavior of ejaculated sperm, possibly providing them with an advantage over epididymal sperm for reaching the eggs in vivo. PMID:25996155

  18. a Cumulus Parameterization Study with Special Attention to the Arakawa-Schubert Scheme

    NASA Astrophysics Data System (ADS)

    Kao, Chih-Yue Jim

    Arakawa and Schubert (1974) developed a cumulus parameterization scheme in a framework that conceptually divides the mutual interaction of the cumulus convection and large-scale disturbance into the categories of large -scale budget requirements and the quasi-equilibrium assumption of cloud work function. We have applied the A-S scheme through a semi-prognostic approach to two different data sets: one is for an intense tropical cloud band event; the other is for tropical composite easterly wave disturbances. Both were observed in GATE. The cloud heating and drying effects predicted by the Arakawa-Schubert scheme are found to agree rather well with the observations. However, it is also found that the Arakawa-Schubert scheme underestimates both condensation and evaporation rates substantially when compared with the cumulus ensemble model results (Soong and Tao, 1980; Tao, 1983). An inclusion of the downdraft effects, as formulated by Johnson (1976), appears to alleviate this deficiency. In order to examine how the Arakawa-Schubert scheme works in a fully prognostic problem, a simulation of the evolution and structure of the tropical cloud band, mentioned above, under the influence of an imposed large-scale low -level forcing has been made, using a two-dimensional hydrostatic model with the inclusion of the Arakawa-Schubert scheme. Basically, the model result indicates that the meso-scale convective system is driven by the excess of the convective heating derived from the Arakawa-Schubert scheme over the adiabatic cooling due to the imposed large-scale lifting and induced meso-scale upward motion. However, as the convective system develops, the adiabatic warming due to the subsidence outside the cloud cluster gradually accumulates into a secondary temperature anomaly which subsequently reduces the original temperature contrast and inhibits the further development of the convective system. A 24 hour integration shows that the model is capable of simulating many

  19. Observational estimates of detrainment and entrainment in non-precipitating shallow cumulus

    NASA Astrophysics Data System (ADS)

    Norgren, M. S.; Small, J. D.; Jonsson, H. H.; Chuang, P. Y.

    2014-08-01

    Vertical transport associated with cumulus clouds is important to the redistribution of gases, particles and energy, with subsequent consequences for many aspects of the climate system. Previous studies have suggested that detrainment from clouds can be comparable to the updraft mass flux, and thus represents an important contribution to vertical transport. In this study, we describe a new method to deduce the amounts of gross detrainment and entrainment experienced by non-precipitating cumulus clouds using aircraft observations. The method utilizes equations for three conserved variables: cloud mass, total water and moist static energy. Optimizing these three equations leads to estimates of the mass fractions of adiabatic mixed-layer air, entrained air and detrained air that the sampled cloud has experienced. The method is applied to six flights of the CIRPAS Twin Otter during the Gulf of Mexico Atmospheric Composition and Climate Study (GoMACCS) which took place in the Houston, Texas region during the summer of 2006 during which 176 small, non-precipitating cumulus were sampled. Our analysis suggests that, on average, these clouds were comprised of 30 to 70% mixed-layer air, with entrained air comprising most of the remainder. The mass fraction of detrained air was less than 2% for a majority of the clouds, although 15% of them did exhibit detrained air fractions larger than 10%. Entrained and detrained air mass fractions both increased with altitude, and the largest detrainment events were almost all associated with air that was at their level of neutral buoyancy, findings that are consistent with previous studies.

  20. Momentum Transport: 2D and 3D Cloud Resolving Model Simulations

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo

    2001-01-01

    The major objective of this study is to investigate the momentum budgets associated with several convective systems that developed during the TOGA COARE IOP (west Pacific warm pool region) and GATE (east Atlantic region). The tool for this study is the improved Goddard Cumulas Ensemble (GCE) model which includes a 3-class ice-phase microphysical scheme, explicit cloud radiative interactive processes and air-sea interactive surface processes. The model domain contains 256 x 256 grid points (with 2 km resolution) in the horizontal and 38 grid points (to a depth of 22 km) in the vertical. The 2D domain has 1024 grid points. The simulations were performed over a 7-day time period (December 19-26, 1992, for TOGA COARE and September 1-7, 1994 for GATE). Cyclic literal boundary conditions are required for this type of long-term integration. Two well organized squall systems (TOGA, COARE February 22, 1993, and GATE September 12, 1994) were also simulated using the 3D GCE model. Only 9 h simulations were required to cover the life time of the squall systems. the lateral boundary conditions were open for these two squall systems simulations. the following will be examined: (1) the momentum budgets in the convective and stratiform regions, (2) the relationship between momentum transport and cloud organization (i.e., well organized squall lines versus less organized convective), (3) the differences and similarities in momentum transport between 2D and 3D simulated convective systems, and (4) the differences and similarities in momentum budgets between cloud systems simulated with open and cyclic lateral boundary conditions. Preliminary results indicate that there are only small differences between 2D and 3D simulated momentum budgets. Major differences occur, however, between momentum budgets associated with squall systems simulated using different lateral boundary conditions.

  1. Metrology for graphene and 2D materials

    NASA Astrophysics Data System (ADS)

    Pollard, Andrew J.

    2016-09-01

    The application of graphene, a one atom-thick honeycomb lattice of carbon atoms with superlative properties, such as electrical conductivity, thermal conductivity and strength, has already shown that it can be used to benefit metrology itself as a new quantum standard for resistance. However, there are many application areas where graphene and other 2D materials, such as molybdenum disulphide (MoS2) and hexagonal boron nitride (h-BN), may be disruptive, areas such as flexible electronics, nanocomposites, sensing and energy storage. Applying metrology to the area of graphene is now critical to enable the new, emerging global graphene commercial world and bridge the gap between academia and industry. Measurement capabilities and expertise in a wide range of scientific areas are required to address this challenge. The combined and complementary approach of varied characterisation methods for structural, chemical, electrical and other properties, will allow the real-world issues of commercialising graphene and other 2D materials to be addressed. Here, examples of metrology challenges that have been overcome through a multi-technique or new approach are discussed. Firstly, the structural characterisation of defects in both graphene and MoS2 via Raman spectroscopy is described, and how nanoscale mapping of vacancy defects in graphene is also possible using tip-enhanced Raman spectroscopy (TERS). Furthermore, the chemical characterisation and removal of polymer residue on chemical vapour deposition (CVD) grown graphene via secondary ion mass spectrometry (SIMS) is detailed, as well as the chemical characterisation of iron films used to grow large domain single-layer h-BN through CVD growth, revealing how contamination of the substrate itself plays a role in the resulting h-BN layer. In addition, the role of international standardisation in this area is described, outlining the current work ongoing in both the International Organization of Standardization (ISO) and the

  2. The mouse ruby-eye 2(d) (ru2(d) /Hps5(ru2-d) ) allele inhibits eumelanin but not pheomelanin synthesis.

    PubMed

    Hirobe, Tomohisa; Ito, Shosuke; Wakamatsu, Kazumasa

    2013-09-01

    The novel mutation named ru2(d) /Hps5(ru2-d) , characterized by light-colored coats and ruby-eyes, prohibits differentiation of melanocytes by inhibiting tyrosinase (Tyr) activity, expression of Tyr, Tyr-related protein 1 (Tyrp1), Tyrp2, and Kit. However, it is not known whether the ru2(d) allele affects pheomelanin synthesis in recessive yellow (e/Mc1r(e) ) or in pheomelanic stage in agouti (A) mice. In this study, effects of the ru2(d) allele on pheomelanin synthesis were investigated by chemical analysis of melanin present in dorsal hairs of 5-week-old mice from F2 generation between C57BL/10JHir (B10)-co-isogenic ruby-eye 2(d) and B10-congenic recessive yellow or agouti. Eumelanin content was decreased in ruby-eye 2(d) and ruby-eye 2(d) agouti mice, whereas pheomelanin content in ruby-eye 2(d) recessive yellow and ruby-eye 2(d) agouti mice did not differ from the corresponding Ru2(d) /- mice, suggesting that the ru2(d) allele inhibits eumelanin but not pheomelanin synthesis. PMID:23672590

  3. Evolution of the Systems Engineering Education Development (SEED) Program at NASA Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Bagg, Thomas C., III; Brumfield, Mark D.; Jamison, Donald E.; Granata, Raymond L.; Casey, Carolyn A.; Heller, Stuart

    2003-01-01

    The Systems Engineering Education Development (SEED) Program at NASA Goddard Space Flight Center develops systems engineers from existing discipline engineers. The program has evolved significantly since the report to INCOSE in 2003. This paper describes the SEED Program as it is now, outlines the changes over the last year, discusses current status and results, and shows the value of human systems and leadership skills for practicing systems engineers.

  4. A visiting scientist program in atmospheric sciences for the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Davis, M. H.

    1989-01-01

    A visiting scientist program was conducted in the atmospheric sciences and related areas at the Goddard Laboratory for Atmospheres. Research was performed in mathematical analysis as applied to computer modeling of the atmospheres; development of atmospheric modeling programs; analysis of remotely sensed atmospheric, surface, and oceanic data and its incorporation into atmospheric models; development of advanced remote sensing instrumentation; and related research areas. The specific research efforts are detailed by tasks.

  5. Thermal Technology Development Activities at the Goddard Space Flight Center - 2001

    NASA Technical Reports Server (NTRS)

    Butler, Dan

    2002-01-01

    This presentation provides an overview of thermal technology development activities carried out at NASA's Goddard Space Flight Center during 2001. Specific topics covered include: two-phase systems (heat pipes, capillary pumped loops, vapor compression systems and phase change materials), variable emittance systems, advanced coatings, high conductivity materials and electrohydrodynamic (EHD) thermal coatings. The application of these activities to specific space missions is also discussed.

  6. Applications of ANSYS/Multiphysics at NASA/Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Loughlin, Jim

    2007-01-01

    This viewgraph presentation reviews some of the uses that the ANSYS/Multiphysics system is used for at the NASA Goddard Space Flight Center. Some of the uses of the ANSYS system is used for is MEMS Structural Analysis of Micro-mirror Array for the James Web Space Telescope (JWST), Micro-shutter Array for JWST, MEMS FP Tunable Filter, AstroE2 Micro-calorimeter. Various views of these projects are shown in this presentation.

  7. Space applications of artificial intelligence; 1990 Goddard Conference, Greenbelt, MD, May 1, 2, 1990, Selected Papers

    NASA Technical Reports Server (NTRS)

    Rash, James L. (Editor)

    1990-01-01

    The papers presented at the 1990 Goddard Conference on Space Applications of Artificial Intelligence are given. The purpose of this annual conference is to provide a forum in which current research and development directed at space applications of artificial intelligence can be presented and discussed. The proceedings fall into the following areas: Planning and Scheduling, Fault Monitoring/Diagnosis, Image Processing and Machine Vision, Robotics/Intelligent Control, Development Methodologies, Information Management, and Knowledge Acquisition.

  8. Cumulus cloud base height estimation from high spatial resolution Landsat data - A Hough transform approach

    NASA Technical Reports Server (NTRS)

    Berendes, Todd; Sengupta, Sailes K.; Welch, Ron M.; Wielicki, Bruce A.; Navar, Murgesh

    1992-01-01

    A semiautomated methodology is developed for estimating cumulus cloud base heights on the basis of high spatial resolution Landsat MSS data, using various image-processing techniques to match cloud edges with their corresponding shadow edges. The cloud base height is then estimated by computing the separation distance between the corresponding generalized Hough transform reference points. The differences between the cloud base heights computed by these means and a manual verification technique are of the order of 100 m or less; accuracies of 50-70 m may soon be possible via EOS instruments.

  9. Boundary-layer cumulus over land: Some observations and conceptual models

    SciTech Connect

    Stull, R.B.

    1993-09-01

    Starting in 1980, the Boundary Layer Research Team at the University of Wisconsin has been systematically studying the formation and evolution of nonprecipitating boundary-layer cumulus clouds (BLCu) in regions of fair weather (anticyclones) over land (Stull, 1980). Our approach is to quantify the average statistical characteristics of the surface, thermals, boundary layer, and clouds over horizontal regions of roughly 20 km in diameter. Within such a region over land, there is typically quite a variation in land use, and associated variations in surface albedo and moisture.

  10. A microphysical connection among biomass burning, cumulus clouds, and stratospheric moisture.

    PubMed

    Sherwood, Steven

    2002-02-15

    A likely causal chain is established here that connects humidity in the stratosphere, relative humidity near the tropical tropopause, ice crystal size in towering cumulus clouds, and aerosols associated with tropical biomass burning. The connections are revealed in satellite-observed fluctuations of each quantity on monthly to yearly time scales. More aerosols lead to smaller ice crystals and more water vapor entering the stratosphere. The connections are consistent with physical reasoning, probably hold on longer time scales, and may help to explain why stratospheric water vapor appears to have been increasing for the past five decades. PMID:11847336

  11. Apoptosis occurs in granulosa cells but not cumulus cells in the atretic antral follicles in pig ovaries.

    PubMed

    Manabe, N; Imai, Y; Ohno, H; Takahagi, Y; Sugimoto, M; Miyamoto, H

    1996-07-15

    The porcine antral follicles, 3-6 mm in diameter, were dissected from the ovaries of mature pigs, and then granulosa and cumulus cells were isolated from each follicle. In atretic follicles, high activity of neutral Ca2+/Mg2+-dependent endonuclease and DNA ladder formation, estimated by electrophoresis, were noted in granulosa cells but not in cumulus cells. Extremely low activity of the endonuclease and no DNA ladder formation were observed in both types of cells obtained from healthy follicles. Moreover, apoptotic cells were observed histochemically among granulosa cells only. A good correlation (r = 0.987) between the endonuclease activity of granulosa cells and the progesterone/estradiol ratio of follicular fluid in each follicle was found. These results suggest that apoptosis occurs in granulosa cells but not cumulus cells in the atretic antral follicles in pigs. PMID:8698104

  12. A case study of cumulus formation beneath a stratocumulus sheet: Its structure and effect on boundary layer budgets

    NASA Technical Reports Server (NTRS)

    Barlow, Roy W.; Nicholls, S.

    1990-01-01

    On several occasions during the FIRE Marine Stratocumulus IFO off the California coast, small cumulus were observed to form during the morning beneath the main stratocumulus (Sc) deck. This occurs in the type of situation described by Turton and Nicholls (1987) in which there is insufficient generation of turbulent kinetic energy (TKE) from the cloudtop or the surface to sustain mixing throughout the layer, and a separation of the surface and cloud layers occurs. The build up of humidity in the surface layer allows cumuli to form, and the more energetic of these may penetrate back into the Sc deck, reconnecting the layers. The results presented were collected by the UKMO C-130 aircraft flying in a region where these small cumulus had grown to the extent that they had penetrated into the main Sc deck above. The structure of these penetrative cumulus are examined and their implications on the layer flux and radiation budget discussed.

  13. Boundary-layer cumulus over heterogeneous landscapes: A subgrid GCM parameterization. Final report, December 1991--November 1995

    SciTech Connect

    Stull, R.B.; Tripoli, G.

    1996-01-08

    The authors developed single-column parameterizations for subgrid boundary-layer cumulus clouds. These give cloud onset time, cloud coverage, and ensemble distributions of cloud-base altitudes, cloud-top altitudes, cloud thickness, and the characteristics of cloudy and clear updrafts. They tested and refined the parameterizations against archived data from Spring and Summer 1994 and 1995 intensive operation periods (IOPs) at the Southern Great Plains (SGP) ARM CART site near Lamont, Oklahoma. The authors also found that: cloud-base altitudes are not uniform over a heterogeneous surface; tops of some cumulus clouds can be below the base-altitudes of other cumulus clouds; there is an overlap region near cloud base where clear and cloudy updrafts exist simultaneously; and the lognormal distribution of cloud sizes scales to the JFD of surface layer air and to the shape of the temperature profile above the boundary layer.

  14. Oocyte developmental competence after in vitro maturation depends on the persistence of cumulus-oocyte comunications which are linked to the intracellular concentration of cAMP.

    PubMed

    Modina, S; Luciano, A M; Vassena, R; Baraldi-Scesi, L; Lauria, A; Gandolfi, F

    2001-01-01

    Oocyte and cumulus cells are interconnected by an extensive network of gap junctions (GJ) formed by connexin 43. In the present study the functional and morphological status of GJ was investigated during in vitro maturation of bovine oocytes using media known to induce different rates of maturation and developmental competence as well as different levels of cumulus expansion and intracellular concentrations of cAMP. GJ functional condition was studied by microinjection of the fluorescent dye Lucyfer Yellow in cumulus-enclosed oocytes and the intracellular distribution of connexin 43 was examined by immunofluorescence immunocytochemistry. Both functional and morphological analysis of GJ between oocytes and cumulus cells indicated that high maturation and development rates are accompanied by the prolonged persistence of permeable communications, which, however, are independent from cumulus expansion. On the contrary, the premature interruption of such communications was linked to low maturation and development. When these results were correlated to the measurements of intracellular levels of cAMP it was observed that cumulus expansion, GJ permeability and good quality maturation require the highest levels of cAMP. Intermediate cAMP levels determine GJ permeability and good quality maturation in the absence of cumulus expansion while below a threshold level of cAMP, oocyte maturation is defective with a premature interruption of communications through GJ and lack of cumulus expansion which lead to poor development. PMID:11732583

  15. Non-invasive assessment of porcine oocyte quality by supravital staining of cumulus-oocyte complexes with lissamine green B.

    PubMed

    Dutta, Rahul; Li, Shun; Fischer, Konrad; Kind, Alexander; Flisikowska, Tatiana; Flisikowski, Krzysztof; Rottmann, Oswald; Schnieke, Angelika

    2016-06-01

    We evaluated the usefulness of lissamine green B (LB) staining of cumulus-oocyte complexes (COC) as a non-invasive method of predicting maturational and developmental competence of slaughterhouse-derived porcine oocytes cultured in vitro. Cumulus cells of freshly aspirated COCs were evaluated either morphologically on the basis of thickness of cumulus cell layers, or stained with LB, which penetrates only non-viable cells. The extent of cumulus cell staining was taken as an inverse indicator of membrane integrity. The two methods of COC grading were then examined as predictors of nuclear maturation and development after parthenogenetic activation. In both cases LB staining proved a more reliable indicator than morphological assessment (P < 0.05). The relationship between LB staining and cumulus cell apoptosis was also examined. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay for DNA fragmentation revealed that oocytes within COCs graded as low quality by either LB staining or visual morphology showed significantly greater DNA fragmentation (P < 0.05) than higher grades, and that LB and visual grading were of similar predictive value. Expression of the stress response gene TP53 showed significantly higher expression in COCs graded as low quality by LB staining. However expression of the apoptosis-associated genes BAK and CASP3 was not significantly different between high or low grade COCs, suggesting that mRNA expression of BAK and CASP3 is not a reliable method of detecting apoptosis in porcine COCs. Evaluation of cumulus cell membrane integrity by lissamine green B staining thus provides a useful new tool to gain information about the maturational and developmental competence of porcine oocytes. PMID:27172057

  16. Contributions to the implementation of the Arakawa-Schubert cumulus parameterization in the GLA GCM. [GCM (general circulation model)

    SciTech Connect

    Sud, Y.C.; Chao, W.C.; Walker, G.K. )

    1991-07-01

    Several integrations were made with a coarse version of the GLA GCM, which has the Arakawa-Schubert cumulus parameterization, predicted fractional cloud cover, and a parameterization of evaporation of falling rainfall. All model simulation experiments started from ECMWF analysis for 15 December 1982 and were integrated until 31 January 1983 using climatological boundary conditions. The first ten days of model integrations show that the model-simulated tropics dries and warms as a result of excessive precipitation. Three types of model development-cum-analysis studies were made with the cumulus scheme. First, the Critical Cloud Work Function (CCWF) dataset for different sigma layers were reworked using the Cloud Work Function (CWF) database of lord et al. as representative of time-average CWF and not the actual CCWF values as in the Arakawa-Schubert implementation of cumulus convection. The experiments with the new CCWF dataset helped to delineate influence of changing CCWF on model simulations. Larger values of CCWF partially alleviated the problem of excessive heating and drying during spinup and sharpened the tropical ITCZ (Intertropical Convergence Zone). Second, by comparing two simulations, one with and one without cumulus convection, the role of cumulus convection in maintaining observed tropical rainfall and 850 mb easterly winds is clarified. Third, relations between cloud radii and cumulus entrainment parameter, [lambda], realistic upper and lower bounds on [lambda] were obtained. This improvement had a great impact on the time evolution of tropical temperature and humidity simulation. It also suppressed excessive rainfall during spinup. Finally, by invoking [lambda][sub min] = 0.0002 m[sup [minus]1] (R[sub max] = 1.00 km) another simulation was made. In this simulation, not only the excessive initial rainfall was virtually eliminated, but a more realistic vertical distribution of specific humidity in the tropics was produced. 22 refs., 29 figs., 3 tabs.

  17. Disruption of Bidirectional Oocyte-Cumulus Paracrine Signaling During In Vitro Maturation Reduces Subsequent Mouse Oocyte Developmental Competence1

    PubMed Central

    Yeo, Christine X.; Gilchrist, Robert B.; Lane, Michelle

    2009-01-01

    Oocyte-cumulus cell bidirectional communication is essential for normal development of the oocyte and cumulus cells (CCs) within the follicle. We showed recently that addition of recombinant growth differentiation factor 9 (GDF9), which signals through the SMAD2/3 pathway, during mouse oocyte in vitro maturation (IVM) increased fetal viability. This study thus aimed to observe the effects of disrupting oocyte-CC bidirectional communication during IVM on oocyte developmental competence and fetal outcomes. Cumulus-oocyte complexes (COCs) from equine chorionic gonadotropin-primed prepubertal (CBA/C57BL6) mice were cultured with or without 50 mIU/ml follicle-stimulating hormone (FSH) and 10 ng/ml epidermal growth factor (EGF) or 4 μM SMAD2/3 inhibitor SB-431542. Cumulus expansion and first polar body extrusion were then assessed, or COCs were fertilized and stained to evaluate sperm entry or cultured to the blastocyst stage. Embryo development and blastocyst quality were assessed, and Day 4.5 blastocysts were transferred to pseudopregnant recipients to analyze fetal outcomes. SMAD2/3 inhibition or FSH/EGF absence during IVM resulted in decreased cumulus expansion. First polar body extrusion and sperm entry were decreased in the absence of FSH/EGF, whereas only sperm entry was affected in SB-431542-matured COCs. Embryo development and blastocyst rates were unaffected; however, blastocyst quality was significantly altered, with reduced inner cell mass cell numbers in embryos derived from COCs matured in both treatments. When COCs were matured with SB-431542 in the absence of FSH/EGF, cumulus expansion was reduced, but fertilization, embryo development, and embryo quality were not. Inhibition of SMAD2/3 signaling in the presence of FSH/EGF significantly reduced fetal survival but had no effect on implantation or fetal and placental dimensions and morphology. PMID:19144958

  18. Gene expression in bovine oocytes and cumulus cells after meiotic inhibition with the cyclin-dependent kinase inhibitor butyrolactone I.

    PubMed

    Leal, C L V; Mamo, S; Fair, T; Lonergan, P

    2012-08-01

    The aim of this study was to determine the effect of temporary inhibition of meiosis using the cyclin-dependent kinase inhibitor butyrolactone I (BLI) on gene expression in bovine oocytes and cumulus cells. Immature bovine cumulus-oocyte complexes (COCs) were assigned to groups: (i) Control COCs collected immediately after recovery from the ovary or (ii) after in vitro maturation (IVM) for 24 h, (iii) Inhibited COCs collected 24 h after incubation with 100 μm BLI or (iv) after meiotic inhibition for 24 h followed by IVM for a further 22 h. For mRNA relative abundance analysis, pools of 10 denuded oocytes and respective cumulus cells were collected. Transcripts related to cell cycle regulation and oocyte competence were evaluated in oocytes and cumulus cells by quantitative real-time PCR (qPCR). Most of the examined transcripts were downregulated (p < 0.05) after IVM in control and inhibited oocytes (19 of 35). Nine transcripts remained stable (p > 0.05) after IVM in control oocytes; only INHBA did not show this pattern in inhibited oocytes. Seven genes were upregulated after IVM in control oocytes (p < 0.05), and only PLAT, RBP1 and INHBB were not upregulated in inhibited oocytes after IVM. In cumulus cells, six genes were upregulated (p < 0.05) after IVM and eight were downregulated (p < 0.05). Cells from inhibited oocytes showed the same pattern of expression regarding maturation profile, but were affected by the temporary meiosis inhibition of the oocyte when the same maturation stages were compared between inhibited and control groups. In conclusion, changes in transcript abundance in oocytes and cumulus cells during maturation in vitro were mostly mirrored after meiotic inhibition followed by maturation. PMID:22034924

  19. The Nuclear Maturation and Embryo Development of Mice Germinal Vesicle Oocytes with and without Cumulus Cell after Vitrification

    PubMed Central

    Nikseresht, Mohsen; Toori, Mehdi Akbartabar; Rasti, Tahere; Kashani, Iraj Ragerdi

    2015-01-01

    Background: Cryobiology is an essential tool in assisted reproductive technology. Research in this area focuses on the possibility of restoring fertility in women with reproductive problems or after cancer treatments. Aim: The purpose of this study was to evaluate viability of oocytes, In vitro maturation and embryo development in vitrified germinal vesicle oocytes with and without cumulus cell after single and stepwise vitrification procedure. Materials and Methods: Germinal vesicle oocytes with or without cumulus cells were obtained from 4 weeks old female mice 48h after intraperitoneal injection of 7.5 IU pregnant mare serum gonadotropin (PMSG). For vitrification collected oocytes vitrification were exposed to cryoprotectant, which was composed of 30% (v/v) ethylene glycol, 18% (w/v) Ficoll-70, and 0.3 M sucrose, either by single step or in a step-wise way. After exposure to cryoprotectant and immerged in liquid nitrogen, the oocytes were thawed and washed in medium TCM199 two times. Then the oocytes transferred to IVM medium for maturation and embryo development to blastocyst. Results: The oocytes survival rates after vitrifying-warming, maturation rate, the capacity of fertilization and embryonic development to blastocyst were examined in vitro. The oocytes survival, maturation to MII, fertilization developmental rate in the step-wise exposure and with cumulus cell was significantly higher (p<0.05) as compared with corresponding rate in the single step procedure without cumulus cell. Conclusion: The results of present study indicated that oocytes vitrified with cumulus cells and stepwise procedure had positive effect on maturation and developmental rate to blastocyst than oocytes without cumulus cell and single step procedure. PMID:25737969

  20. A new inversion method for (T2, D) 2D NMR logging and fluid typing

    NASA Astrophysics Data System (ADS)

    Tan, Maojin; Zou, Youlong; Zhou, Cancan

    2013-02-01

    One-dimensional nuclear magnetic resonance (1D NMR) logging technology has some significant limitations in fluid typing. However, not only can two-dimensional nuclear magnetic resonance (2D NMR) provide some accurate porosity parameters, but it can also identify fluids more accurately than 1D NMR. In this paper, based on the relaxation mechanism of (T2, D) 2D NMR in a gradient magnetic field, a hybrid inversion method that combines least-squares-based QR decomposition (LSQR) and truncated singular value decomposition (TSVD) is examined in the 2D NMR inversion of various fluid models. The forward modeling and inversion tests are performed in detail with different acquisition parameters, such as magnetic field gradients (G) and echo spacing (TE) groups. The simulated results are discussed and described in detail, the influence of the above-mentioned observation parameters on the inversion accuracy is investigated and analyzed, and the observation parameters in multi-TE activation are optimized. Furthermore, the hybrid inversion can be applied to quantitatively determine the fluid saturation. To study the effects of noise level on the hybrid method and inversion results, the numerical simulation experiments are performed using different signal-to-noise-ratios (SNRs), and the effect of different SNRs on fluid typing using three fluid models are discussed and analyzed in detail.

  1. New, Improved Goddard Bulk-Microphysical Schemes for Studying Precipitation Processes in WRF

    NASA Technical Reports Server (NTRS)

    Tao, Wei-Kuo

    2007-01-01

    An improved bulk microphysical parameterization is implemented into the Weather Research and Forecasting ()VRF) model. This bulk microphysical scheme has three different options, 2ICE (cloud ice & snow), 3ICE-graupel (cloud ice, snow & graupel) and 3ICE-hail (cloud ice, snow & hail). High-resolution model simulations are conducted to examine the impact of microphysical schemes on two different weather events (a midlatitude linear convective system and an Atlantic hurricane). The results suggest that microphysics has a major impact on the organization and precipitation processes associated with a summer midlatitude convective line system. The Goddard 3ICE scheme with a cloud ice-snow-hail configuration agreed better with observations in terms of rainfall intensity and a narrow convective line than did simulations with a cloud ice-snow-graupel or cloud ice-snow (i.e., 2ICE) configuration. This is because the 3ICE-hail scheme includes dense ice precipitating (hail) particle with very fast fall speed (over 10 in For an Atlantic hurricane case, the Goddard microphysical schemes had no significant impact on the track forecast but did affect the intensity slightly. The improved Goddard schemes are also compared with WRF's three other 3ICE bulk microphysical schemes: WSM6, Purdue-Lin and Thompson. For the summer midlatitude convective line system, all of the schemes resulted in simulated precipitation events that were elongated in the southwest-northeast direction in qualitative agreement with the observed feature. However, the Goddard 3ICE scheme with the hail option and the Thompson scheme agree better with observations in terms of rainfall intensity, expect that the Goddard scheme simulated more heavy rainfall (over 48 mm/h). For the Atlantic hurricane case, none of the schemes had a significant impact on the track forecast; however, the simulated intensity using the Purdue-Lin scheme was much stronger than the other schemes. The vertical distributions of model

  2. Dreams, Hopes, Realities: NASA's Goddard Space Flight Center, the First Forty Years

    NASA Technical Reports Server (NTRS)

    Wallace, Lane E.

    1999-01-01

    Throughout history, the great achievements of civilizations and cultures have been recorded in lists of dates and events. But to look only at the machinery, discoveries, or milestones is to miss the value of these achievements. Each goal achieved or discovery or made represents a supreme effort on the part of individual people who came and worked together for a purpose greater than themselves. Driven by an innate curiosity of the spirit, we have built civilizations and discovered new worlds, always reaching out beyond what we knew or thought was possible. These efforts may have used ships or machinery, but the achievement was that of the humans who made those machines possible- remarkable people willing to endure discomfort, frustration, fatigue, and the risk of failure in the hope of finding out something new. This is the case with the history of the Goddard Space Flight Center. This publication traces the legacy of successes, risks, disappointments and internationally recognized triumphs of the Center's first 40 years. It is a story of technological achievement and scientific discovery; of reaching back to the dawn of time and opening up a new set of eyes on our own planet Earth. In the end, it is not a story about machinery or discoveries, but a story about ourselves. If we were able to step off our planet, and if we continue to discover new mysteries and better technology, it is because the people who work at Goddard always had a passion for exploration and the dedication to make it happen. The text that follows is a testimony to the challenges people at the Goddard Space Flight Center have faced and overcome over almost half a century. Today, we stand on the threshold of a new and equally challenging era. It will once again test our ingenuity, skills, and flexibility as we find new ways of working with our colleagues in industry, government, and academia. Doing more with less is every bit as ambitious as designing the first science instrument to study the

  3. Changes in cumulus-oocyte complexes of pregnant and non-pregnant camels (Camelus dromedarius) during maturation in vitro.

    PubMed

    Torner, H; Heleil, B; Alm, H; Ghoneim, I M; Srsen, V; Kanitz, W; Tuchscherer, A; Fattouh, E M

    2003-09-15

    The aim of the present study was to examine the cumulus morphology and the oocyte chromatin quality of camel cumulus-oocyte complexes (COCs) at the time of recovery, and to monitor changes in oocyte chromatin configuration and apoptosis in cumulus cells from camel COCs during in vitro maturation (IVM) (0, 12, 24, 32, 36, 42, and 48 p.IVM) depending on pregnancy of donors. A total of 1023 COCs were isolated from sliced ovaries after slaughtering of 47 pregnant and 43 non-pregnant camels in an abattoir. The mean number of COCs per donor was 10.3 in pregnant and 12.5 in non-pregnant donors. The cumulus morphology of COCs was independent of the type of donor and was divided in COCs with compact (26.9 and 28%), dispersed (39.3 and 46%), corona radiata cumulus investment (27.9 and 21.7%) and without cumulus (6 and 4.2%), respectively for pregnant and non-pregnant donors. The highest proportion of COCs exhibited dispersed cumulus (P<0.05). Oocytes with meiotic stages of diplotene >50% were found only in compact (55 and 56.5%) and in dispersed COCs (58.4 and 60%), respectively for pregnant and non-pregnant donors. During IVM (0-48h) the first significant onset of specific meiotic stages were different in oocytes from pregnant donors: metaphase 1 (24-32h), metaphase 2 (36-42h), versus oocytes from non-pregnant donors: metaphase 1 (24h), metaphase 2 (32-48h) (P<0.05). The level of apoptotic cells in cumuli of matured COCs increased during IVM and was higher in matured COCs from non-pregnant donors for each time point during IVM (P<0.01). Camel oocytes meiosis during IVM is accompanied by a drastic increase of apoptosis in the surrounding cumulus cells 0-32 and 0-24h during IVM, respectively for pregnant and non-pregnant donors. The oocytes of pregnant camels require 36h of maturation to reach levels of >50% metaphase 2 stage in comparison to oocytes from non-pregnant donors where 32h are sufficient. The earlier onset of apoptosis in the COCs derived from non-pregnant donors

  4. Radiofrequency Spectroscopy and Thermodynamics of Fermi Gases in the 2D to Quasi-2D Dimensional Crossover

    NASA Astrophysics Data System (ADS)

    Cheng, Chingyun; Kangara, Jayampathi; Arakelyan, Ilya; Thomas, John

    2016-05-01

    We tune the dimensionality of a strongly interacting degenerate 6 Li Fermi gas from 2D to quasi-2D, by adjusting the radial confinement of pancake-shaped clouds to control the radial chemical potential. In the 2D regime with weak radial confinement, the measured pair binding energies are in agreement with 2D-BCS mean field theory, which predicts dimer pairing energies in the many-body regime. In the qausi-2D regime obtained with increased radial confinement, the measured pairing energy deviates significantly from 2D-BCS theory. In contrast to the pairing energy, the measured radii of the cloud profiles are not fit by 2D-BCS theory in either the 2D or quasi-2D regimes, but are fit in both regimes by a beyond mean field polaron-model of the free energy. Supported by DOE, ARO, NSF, and AFOSR.

  5. The National Aeronautics and Space Administration (NASA)/Goddard Space Flight Center (GSFC) sounding-rocket program

    NASA Technical Reports Server (NTRS)

    Guidotti, J. G.

    1976-01-01

    An overall introduction to the NASA sounding rocket program as managed by the Goddard Space Flight Center is presented. The various sounding rockets, auxiliary systems (telemetry, guidance, etc.), launch sites, and services which NASA can provide are briefly described.

  6. Development of Two-Moment Cloud Microphysics for Liquid and Ice Within the NASA Goddard Earth Observing System Model (GEOS-5)

    NASA Technical Reports Server (NTRS)

    Barahona, Donifan; Molod, Andrea M.; Bacmeister, Julio; Nenes, Athanasios; Gettelman, Andrew; Morrison, Hugh; Phillips, Vaughan,; Eichmann, Andrew F.

    2013-01-01

    This work presents the development of a two-moment cloud microphysics scheme within the version 5 of the NASA Goddard Earth Observing System (GEOS-5). The scheme includes the implementation of a comprehensive stratiform microphysics module, a new cloud coverage scheme that allows ice supersaturation and a new microphysics module embedded within the moist convection parameterization of GEOS-5. Comprehensive physically-based descriptions of ice nucleation, including homogeneous and heterogeneous freezing, and liquid droplet activation are implemented to describe the formation of cloud particles in stratiform clouds and convective cumulus. The effect of preexisting ice crystals on the formation of cirrus clouds is also accounted for. A new parameterization of the subgrid scale vertical velocity distribution accounting for turbulence and gravity wave motion is developed. The implementation of the new microphysics significantly improves the representation of liquid water and ice in GEOS-5. Evaluation of the model shows agreement of the simulated droplet and ice crystal effective and volumetric radius with satellite retrievals and in situ observations. The simulated global distribution of supersaturation is also in agreement with observations. It was found that when using the new microphysics the fraction of condensate that remains as liquid follows a sigmoidal increase with temperature which differs from the linear increase assumed in most models and is in better agreement with available observations. The performance of the new microphysics in reproducing the observed total cloud fraction, longwave and shortwave cloud forcing, and total precipitation is similar to the operational version of GEOS-5 and in agreement with satellite retrievals. However the new microphysics tends to underestimate the coverage of persistent low level stratocumulus. Sensitivity studies showed that the simulated cloud properties are robust to moderate variation in cloud microphysical parameters

  7. Competing coexisting phases in 2D water

    PubMed Central

    Zanotti, Jean-Marc; Judeinstein, Patrick; Dalla-Bernardina, Simona; Creff, Gaëlle; Brubach, Jean-Blaise; Roy, Pascale; Bonetti, Marco; Ollivier, Jacques; Sakellariou, Dimitrios; Bellissent-Funel, Marie-Claire

    2016-01-01

    The properties of bulk water come from a delicate balance of interactions on length scales encompassing several orders of magnitudes: i) the Hydrogen Bond (HBond) at the molecular scale and ii) the extension of this HBond network up to the macroscopic level. Here, we address the physics of water when the three dimensional extension of the HBond network is frustrated, so that the water molecules are forced to organize in only two dimensions. We account for the large scale fluctuating HBond network by an analytical mean-field percolation model. This approach provides a coherent interpretation of the different events experimentally (calorimetry, neutron, NMR, near and far infra-red spectroscopies) detected in interfacial water at 160, 220 and 250 K. Starting from an amorphous state of water at low temperature, these transitions are respectively interpreted as the onset of creation of transient low density patches of 4-HBonded molecules at 160 K, the percolation of these domains at 220 K and finally the total invasion of the surface by them at 250 K. The source of this surprising behaviour in 2D is the frustration of the natural bulk tetrahedral local geometry and the underlying very significant increase in entropy of the interfacial water molecules. PMID:27185018

  8. 2D Radiative Processes Near Cloud Edges

    NASA Technical Reports Server (NTRS)

    Varnai, T.

    2012-01-01

    Because of the importance and complexity of dynamical, microphysical, and radiative processes taking place near cloud edges, the transition zone between clouds and cloud free air has been the subject of intense research both in the ASR program and in the wider community. One challenge in this research is that the one-dimensional (1D) radiative models widely used in both remote sensing and dynamical simulations become less accurate near cloud edges: The large horizontal gradients in particle concentrations imply that accurate radiative calculations need to consider multi-dimensional radiative interactions among areas that have widely different optical properties. This study examines the way the importance of multidimensional shortwave radiative interactions changes as we approach cloud edges. For this, the study relies on radiative simulations performed for a multiyear dataset of clouds observed over the NSA, SGP, and TWP sites. This dataset is based on Microbase cloud profiles as well as wind measurements and ARM cloud classification products. The study analyzes the way the difference between 1D and 2D simulation results increases near cloud edges. It considers both monochromatic radiances and broadband radiative heating, and it also examines the influence of factors such as cloud type and height, and solar elevation. The results provide insights into the workings of radiative processes and may help better interpret radiance measurements and better estimate the radiative impacts of this critical region.

  9. Simulation of Yeast Cooperation in 2D.

    PubMed

    Wang, M; Huang, Y; Wu, Z

    2016-03-01

    Evolution of cooperation has been an active research area in evolutionary biology in decades. An important type of cooperation is developed from group selection, when individuals form spatial groups to prevent them from foreign invasions. In this paper, we study the evolution of cooperation in a mixed population of cooperating and cheating yeast strains in 2D with the interactions among the yeast cells restricted to their small neighborhoods. We conduct a computer simulation based on a game theoretic model and show that cooperation is increased when the interactions are spatially restricted, whether the game is of a prisoner's dilemma, snow drifting, or mutual benefit type. We study the evolution of homogeneous groups of cooperators or cheaters and describe the conditions for them to sustain or expand in an opponent population. We show that under certain spatial restrictions, cooperator groups are able to sustain and expand as group sizes become large, while cheater groups fail to expand and keep them from collapse. PMID:26988702

  10. Phase Engineering of 2D Tin Sulfides.

    PubMed

    Mutlu, Zafer; Wu, Ryan J; Wickramaratne, Darshana; Shahrezaei, Sina; Liu, Chueh; Temiz, Selcuk; Patalano, Andrew; Ozkan, Mihrimah; Lake, Roger K; Mkhoyan, K A; Ozkan, Cengiz S

    2016-06-01

    Tin sulfides can exist in a variety of phases and polytypes due to the different oxidation states of Sn. A subset of these phases and polytypes take the form of layered 2D structures that give rise to a wide host of electronic and optical properties. Hence, achieving control over the phase, polytype, and thickness of tin sulfides is necessary to utilize this wide range of properties exhibited by the compound. This study reports on phase-selective growth of both hexagonal tin (IV) sulfide SnS2 and orthorhombic tin (II) sulfide SnS crystals with diameters of over tens of microns on SiO2 substrates through atmospheric pressure vapor-phase method in a conventional horizontal quartz tube furnace with SnO2 and S powders as the source materials. Detailed characterization of each phase of tin sulfide crystals is performed using various microscopy and spectroscopy methods, and the results are corroborated by ab initio density functional theory calculations. PMID:27099950

  11. Ion Transport in 2-D Graphene Nanochannels

    NASA Astrophysics Data System (ADS)

    Xie, Quan; Foo, Elbert; Duan, Chuanhua

    2015-11-01

    Graphene membranes have recently attracted wide attention due to its great potential in water desalination and selective molecular sieving. Further developments of these membranes, including enhancing their mass transport rate and/or molecular selectivity, rely on the understanding of fundamental transport mechanisms through graphene membranes, which has not been studied experimentally before due to fabrication and measurement difficulties. Herein we report the fabrication of the basic constituent of graphene membranes, i.e. 2-D single graphene nanochannels (GNCs) and the study of ion transport in these channels. A modified bonding technique was developed to form GNCs with well-defined geometry and uniform channel height. Ion transport in such GNCs was studied using DC conductance measurement. Our preliminary results showed that the ion transport in GNCs is still governed by surface charge at low concentrations (10-6M to 10-4M). However, GNCs exhibits much higher ionic conductances than silica nanochannels with the same geometries in the surface-charge-governed regime. This conductance enhancement can be attributed to the pre-accumulation of charges on graphene surfaces. The work is supported by the Faculty Startup Fund (Boston University, USA).

  12. Parallel map analysis on 2-D grids

    SciTech Connect

    Berry, M.; Comiskey, J.; Minser, K.

    1993-12-31

    In landscape ecology, computer modeling is used to assess habitat fragmentation and its ecological iMPLications. Specifically, maps (2-D grids) of habitat clusters must be analyzed to determine number, sizes and geometry of clusters. Models prior to this study relied upon sequential Fortran-77 programs which limited the sizes of maps and densities of clusters which could be analyzed. In this paper, we present more efficient computer models which can exploit recursion or parallelism. Significant improvements over the original Fortran-77 programs have been achieved using both recursive and nonrecursive C implementations on a variety of workstations such as the Sun Sparc 2, IBM RS/6000-350, and HP 9000-750. Parallel implementations on a 4096-processor MasPar MP-1 and a 32-processor CM-5 are also studied. Preliminary experiments suggest that speed improvements for the parallel model on the MasPar MP-1 (written in MPL) and on the CM-5 (written in C using CMMD) can be as much as 39 and 34 times faster, respectively, than the most efficient sequential C program on a Sun Sparc 2 for a 512 map. An important goal in this research effort is to produce a scalable map analysis algorithm for the identification and characterization of clusters for relatively large maps on massively-parallel computers.

  13. 2D Turbulence with Complicated Boundaries

    NASA Astrophysics Data System (ADS)

    Roullet, G.; McWilliams, J. C.

    2014-12-01

    We examine the consequences of lateral viscous boundary layers on the 2D turbulence that arises in domains with complicated boundaries (headlands, bays etc). The study is carried out numerically with LES. The numerics are carefully designed to ensure all global conservation laws, proper boundary conditions and a minimal range of dissipation scales. The turbulence dramatically differs from the classical bi-periodic case. Boundary layer separations lead to creation of many small vortices and act as a continuing energy source exciting the inverse cascade of energy throughout the domain. The detachments are very intermittent in time. In free decay, the final state depends on the effective numerical resolution: laminar with a single dominant vortex for low Re and turbulent with many vortices for large enough Re. After very long time, the turbulent end-state exhibits a striking tendency for the emergence of shielded vortices which then interact almost elastically. In the forced case, the boundary layers allow the turbulence to reach a statistical steady state without any artificial hypo-viscosity or other large-scale dissipation. Implications are discussed for the oceanic mesoscale and submesoscale turbulence.

  14. Competing coexisting phases in 2D water

    NASA Astrophysics Data System (ADS)

    Zanotti, Jean-Marc; Judeinstein, Patrick; Dalla-Bernardina, Simona; Creff, Gaëlle; Brubach, Jean-Blaise; Roy, Pascale; Bonetti, Marco; Ollivier, Jacques; Sakellariou, Dimitrios; Bellissent-Funel, Marie-Claire

    2016-05-01

    The properties of bulk water come from a delicate balance of interactions on length scales encompassing several orders of magnitudes: i) the Hydrogen Bond (HBond) at the molecular scale and ii) the extension of this HBond network up to the macroscopic level. Here, we address the physics of water when the three dimensional extension of the HBond network is frustrated, so that the water molecules are forced to organize in only two dimensions. We account for the large scale fluctuating HBond network by an analytical mean-field percolation model. This approach provides a coherent interpretation of the different events experimentally (calorimetry, neutron, NMR, near and far infra-red spectroscopies) detected in interfacial water at 160, 220 and 250 K. Starting from an amorphous state of water at low temperature, these transitions are respectively interpreted as the onset of creation of transient low density patches of 4-HBonded molecules at 160 K, the percolation of these domains at 220 K and finally the total invasion of the surface by them at 250 K. The source of this surprising behaviour in 2D is the frustration of the natural bulk tetrahedral local geometry and the underlying very significant increase in entropy of the interfacial water molecules.

  15. Competing coexisting phases in 2D water.

    PubMed

    Zanotti, Jean-Marc; Judeinstein, Patrick; Dalla-Bernardina, Simona; Creff, Gaëlle; Brubach, Jean-Blaise; Roy, Pascale; Bonetti, Marco; Ollivier, Jacques; Sakellariou, Dimitrios; Bellissent-Funel, Marie-Claire

    2016-01-01

    The properties of bulk water come from a delicate balance of interactions on length scales encompassing several orders of magnitudes: i) the Hydrogen Bond (HBond) at the molecular scale and ii) the extension of this HBond network up to the macroscopic level. Here, we address the physics of water when the three dimensional extension of the HBond network is frustrated, so that the water molecules are forced to organize in only two dimensions. We account for the large scale fluctuating HBond network by an analytical mean-field percolation model. This approach provides a coherent interpretation of the different events experimentally (calorimetry, neutron, NMR, near and far infra-red spectroscopies) detected in interfacial water at 160, 220 and 250 K. Starting from an amorphous state of water at low temperature, these transitions are respectively interpreted as the onset of creation of transient low density patches of 4-HBonded molecules at 160 K, the percolation of these domains at 220 K and finally the total invasion of the surface by them at 250 K. The source of this surprising behaviour in 2D is the frustration of the natural bulk tetrahedral local geometry and the underlying very significant increase in entropy of the interfacial water molecules. PMID:27185018

  16. 2-D wavelet with position controlled resolution

    NASA Astrophysics Data System (ADS)

    Walczak, Andrzej; Puzio, Leszek

    2005-09-01

    Wavelet transformation localizes all irregularities in the scene. It is most effective in the case when intensities in the scene have no sharp details. It is the case often present in a medical imaging. To identify the shape one has to extract it from the scene as typical irregularity. When the scene does not contain sharp changes then common differential filters are not efficient tool for a shape extraction. The new 2-D wavelet for such task has been proposed. Described wavelet transform is axially symmetric and has varied scale in dependence on the distance from the centre of the wavelet symmetry. The analytical form of the wavelet has been presented as well as its application for details extraction in the scene. Most important feature of the wavelet transform is that it gives a multi-scale transformation, and if zoom is on the wavelet selectivity varies proportionally to the zoom step. As a result, the extracted shape does not change during zoom operation. What is more the wavelet selectivity can be fit to the local intensity gradient properly to obtain best extraction of the irregularities.

  17. The Role of Cold Pools in Mesoscale Organization of Shallow Cumulus and Congestus

    NASA Astrophysics Data System (ADS)

    Mechem, D. B.; Giangrande, S. E.; Turner, D. D.

    2014-12-01

    Cold pool remnants generated by deep convection serve as a stabilizing mechanism against further episodes of convection. Often overlooked, shallower precipitating congestus clouds also generate cold pools at scales ideal for observational study. This study investigates the interaction between showery cumulus congestus and convectively generated cold pools over the ARM SGP (Atmospheric Radiation Measurement Program Southern Great Plains) research site using a multi-sensor observational approach and an ensemble of large-eddy simulation (LES) runs. On 25 May 2011, the C-band and X-band ARM Precipitation Radars (CSAPR, XSAPRs) sampled a field of precipitating shallow convection and accompanying cold pools. The thermodynamic structure of these cold pools was captured by surface observations around the SGP site, including an AERI-based retrieval that yields lower-atmospheric profiles of temperature and moisture. For this event, observations from the ARM scanning radars and vertically pointing sensors (TSI, cloud radar, ceilometer) reveal cold pools produced by precipitating congestus clouds and suggest modest suppression of congestus development across the cold pool interiors. Viewing sequences from ARM scanning radars sensitive to drizzling clouds provide limited evidence for preferential cloud development along cold pool boundaries. The generated cold pools for this event are weak (~2-3 K), but not particularly shallow (~750 m in depth). LES results are employed to establish the joint relationships between cold pool and cloud properties, in particular the effect of cold pools on the shallow cumulus field and further generation of precipitating congestus clouds.

  18. Laboratory simulations show diabatic heating drives cumulus-cloud evolution and entrainment.

    PubMed

    Narasimha, Roddam; Diwan, Sourabh Suhas; Duvvuri, Subrahmanyam; Sreenivas, K R; Bhat, G S

    2011-09-27

    Clouds are the largest source of uncertainty in climate science, and remain a weak link in modeling tropical circulation. A major challenge is to establish connections between particulate microphysics and macroscale turbulent dynamics in cumulus clouds. Here we address the issue from the latter standpoint. First we show how to create bench-scale flows that reproduce a variety of cumulus-cloud forms (including two genera and three species), and track complete cloud life cycles--e.g., from a "cauliflower" congestus to a dissipating fractus. The flow model used is a transient plume with volumetric diabatic heating scaled dynamically to simulate latent-heat release from phase changes in clouds. Laser-based diagnostics of steady plumes reveal Riehl-Malkus type protected cores. They also show that, unlike the constancy implied by early self-similar plume models, the diabatic heating raises the Taylor entrainment coefficient just above cloud base, depressing it at higher levels. This behavior is consistent with cloud-dilution rates found in recent numerical simulations of steady deep convection, and with aircraft-based observations of homogeneous mixing in clouds. In-cloud diabatic heating thus emerges as the key driver in cloud development, and could well provide a major link between microphysics and cloud-scale dynamics. PMID:21918112

  19. Evolution of small cumulus clouds in Florida: observations of pulsating growth

    NASA Astrophysics Data System (ADS)

    French, Jeffrey R.; Vali, Gabor; Kelly, Robert D.

    Observations have been made in six small cumulus clouds using instrumented aircraft, a ground-based radar, and a 95 GHz airborne Doppler radar. The clouds occurred on two days during the Small Cumulus Microphysics Study in east-central Florida, summer 1995. Cloud tops were below 3 km and in-cloud temperatures were warmer than 10°C. Maximum observed reflectivity factors were less than 0 dBZ. The evolution of the kinematics of the observed clouds was tracked using measurements from both radars. High-resolution cross-sections of reflectivity and vertical Doppler velocity from the airborne radar appear remarkably similar to fine-scale models of convection reported in the literature. In general, each cloud resembled a collection of individual bubbles ascending through the boundary layer. During the growth phase of a bubble, a positive correlation existed between vertical velocity and reflectivity. As bubbles penetrated further into the inversion, entrainment/detrainment led to a weakening or, in some cases, a reversal of this correlation. Growth of subsequent bubbles ascending through remnants of earlier bubbles were aided by an increase in the amount of moisture in the environment resulting from earlier detrainment of cloudy air, and thus were able to achieve higher altitudes than their predecessors.

  20. Multi-summer Cumulus-Radiation-Aerosol Climatology at SGP site

    NASA Astrophysics Data System (ADS)

    Kassianov, E.; Berg, L. K.; Flynn, C.; Long, C.; Barnard, J.

    2010-12-01

    Compared to other cloud types, shallow cumulus clouds are relatively small in size and have large variations over time/space that are poorly captured by current large-scale models of the atmosphere. Since these small-scale variations are very difficult to monitor and accurately describe, models improvement is hampered, in part, by the lack of appropriate observational constraints, including cloud and aerosol properties, surface parameters and radiative fluxes. To address this issue, a multi-summer (2000-2007) cumulus-radiation-aerosol climatology has been developed for the U.S. Department of Energy Atmospheric Radiation Measurement (ARM) Southern Great Plains (SGP) Site. In particular, this climatology is applied to illustrate that positive values of shortwave cloud radiative forcing occur frequently and are characterized by fluctuations with a small temporal scale; the duration for the majority of events with positive radiative forcing is less than 5 minutes. In this presentation, the developed climatology will be described and several important applications will be shown.

  1. Impact of Anthropogenic Aerosol on the Properties of Shallow Maritime Cumulus Clouds

    NASA Astrophysics Data System (ADS)

    Gao, L.; Wilcox, E. M.; Shan, Y.

    2015-12-01

    The northern Indian Ocean region is frequently covered by cumulus clouds that are responsible for moistening the boundary layer and contribute to tropical deep convection. Because this region is uniquely located close to the highly polluted Indian plateau, air mass with high aerosol concentration can be easily transported to this area. These small cumulus clouds, coupled with the effects of aerosol, have a large potential to affect the regional and global albedo. The aerosol effects on cloud properties and atmospheric structures are examined in this work, using the UAV (Unmanned Aerial Vehicle) data that are observed from CARDEX (Cloud, Aerosol, Radiative forcing, Dynamics EXperiment) and MAC (Maldives Autonomous unmanned aerial vehicle Campaign). On average, the high polluted cases show warmer temperature through the entire atmospheric column and higher relative humidity in boundary layer. The maximum temperature difference between high and low polluted cases can be found around the cloud layer altitude. In addition, the height of sub-cloud mixed layer is higher in low polluted cases. Clouds in high polluted cases are generally becoming narrower and taller than those in low polluted cases, and are associated with greater cloud water content and higher cloud droplet number concentrations, especially in small droplet range (diameters less than 10 micrometers). Meanwhile, the effective radius of cloud droplets decreases as the aerosol concentration increases. These facts indicate that the high polluted clouds are on average brighter with higher albedo.

  2. Project Overview: Cumulus Humilis Aerosol Processing Study (CHAPS): Proposed Summer 2007 ASP Field Campaign

    SciTech Connect

    Berkowitz, Carl M.; Berg, Larry K.; Ogren, J. A.; Hostetler, Chris A.; Ferrare, Richard

    2006-05-18

    This white paper presents the scientific motivation and preliminary logistical plans for a proposed ASP field campaign to be carried out in the summer of 2007. The primary objective of this campaign is to use the DOE Gulfstream-1 aircraft to make measurements characterizing the chemical, physical and optical properties of aerosols below, within and above large fields of fair weather cumulus and to use the NASA Langley Research Center’s High Spectral Resolution Lidar (HSRL) to make independent measurements of aerosol backscatter and extinction profiles in the vicinity of these fields. Separate from the science questions to be addressed by these observations will be information to add in the development of a parameterized cumulus scheme capable of including multiple cloud fields within a regional or global scale model. We will also be able to compare and contrast the cloud and aerosol properties within and outside the Oklahoma City plume to study aerosol processes within individual clouds. Preliminary discussions with the Cloud and Land Surface Interaction Campaign (CLASIC) science team have identified overlap between the science questions posed for the CLASIC Intensive Operation Period (IOP) and the proposed ASP campaign, suggesting collaboration would benefit both teams.

  3. The development of ice in a cumulus cloud over southwest England

    NASA Astrophysics Data System (ADS)

    Huang, Yahui; Blyth, Alan M.; Brown, Philip R. A.; Choularton, Tom W.; Connolly, Paul; Gadian, Alan M.; Jones, Hazel; Latham, John; Cui, Zhiqiang; Carslaw, Ken

    2008-10-01

    An experiment involving the FAAM BAe 146 aircraft, called the ICE and Precipitation Initiation in Cumulus (ICEPIC) project, was conducted in order to measure the microphysical properties of UK summertime cumulus clouds. A line of clouds was penetrated near the ascending tops. Higher concentrations of ice particles than expected from activation on typical ice nuclei using the Meyers formula were observed at relatively high temperatures (T>-10 °C). The observations of numerous ice particles and the coexistence of both small and large cloud droplets, pristine ice columns and graupel pellets within the temperature zone of -3 to -9 °C strongly suggested the Hallett-Mossop (HM) process of splintering during riming. Agreement between the calculated and observed rates of splinter production supported this suggestion. The Model of Aerosols and Chemistry in Convective Clouds (MAC3) was utilized to establish a quantitative understanding of the observed development of glaciation of this cloud. The results of the model confirmed the important role of the HM process. They also showed that the warm rain process was fundamental to the production of graupel in the cloud studied, and hence the HM ice particles. A sensitivity test with double the concentration of aerosol particles showed that the concentration of supercooled raindrops decreased as expected, which resulted in fewer graupel particles and a smaller quantity of precipitation, which was delayed by about 5 min. However, the production rate of secondary ice particles generated by the HM process increased due to the increased concentration of small cloud droplets.

  4. A Lagrangian drop model to study warm rain microphysical processes in shallow cumulus

    NASA Astrophysics Data System (ADS)

    Naumann, Ann Kristin; Seifert, Axel

    2015-09-01

    In this study, we introduce a Lagrangian drop (LD) model to study warm rain microphysical processes in shallow cumulus. The approach combines Large-Eddy Simulations (LES) including a bulk microphysics parameterization with an LD model for raindrop growth. The LD model is one-way coupled with the Eulerian LES and represents all relevant rain microphysical processes such as evaporation, accretion, and selfcollection among LDs as well as dynamical effects such as sedimentation and inertia. To test whether the LD model is fit for purpose, a sensitivity study for isolated shallow cumulus clouds is conducted. We show that the surface precipitation rate and the development of the raindrop size distribution are sensitive to the treatment of selfcollection in the LD model. Some uncertainty remains for the contribution of the subgrid-scale turbulence to the relative velocity difference of a pair of LDs, which appears as a factor in the collision kernel. Sensitivities to other model parameters such as the initial multiplicity or the initial mass distribution are small. Overall, sensitivities of the LD model are small compared to the uncertainties in the assumptions of the bulk rain microphysics scheme, and the LD model is well suited for particle-based studies of raindrop growth and dynamics. This opens up the opportunity to study effects like recirculation, deviations from terminal fall velocity and other microphysical phenomena that so far were not accessible for bin, bulk, or parcel models.

  5. Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization

    PubMed Central

    Jungheim, Emily S.; Macones, George A.; Odem, Randall R.; Patterson, Bruce W.; Lanzendorf, Susan E.; Ratts, Valerie S.; Moley, Kelle H.

    2011-01-01

    Objective To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex morphology Design Prospective cohort study Setting University in vitro fertilization (IVF) practice Patients 102 women undergoing IVF Interventions Measurement of FFAs in serum and ovarian follicular fluid Main Outcome Measures Total and specific follicular and serum FFA levels, correlations between follicular and serum FFAs, and associations between follicular FFA levels and markers of oocyte quality including cumulus oocyte complex (COC) morphology Results Predominant follicular fluid and serum FFAs were oleic, palmitic, linoleic and stearic acids. Correlations between follicular and serum FFA concentrations were weak (r=0.252, 0.288, 0.236, 0.309 respectively for specific FFAs; r=0.212 for total FFAs). A receiver operator characteristic curve determined total follicular FFAs ≥ 0.232 µmol/ml distinguished women with lower versus higher percentage COCs with favorable morphology. Women with elevated follicular FFAs (n=31) were more likely to have COCs with poor morphology than others (n=71) (OR 3.3, 95% CI:1.2–9.2). This relationship held after adjusting for potential confounders including age, BMI, endometriosis and amount of gonadotropin administered (β=1.2; OR 3.4, 95% CI:1.1–10.4). Conclusions Elevated follicular FFA levels are associated with poor COC morphology. Further work is needed to determine what factors influence follicular FFA levels and if these factors impact fertility. PMID:21353671

  6. Analysis and Numerical Simulation of Humidity Halos around Trade Wind Cumulus Clouds

    NASA Astrophysics Data System (ADS)

    Lu, M.; Wang, J.; Freedman, A.; Jonsson, H. H.; Flagan, R. C.; McClatchey, R. A.; Seinfeld, J. H.

    2002-12-01

    Significant enhancements in humidity above that in the cloud-free atmosphere have been found in the vicinity of isolated cumulus clouds, so-called cloud halos. Cloud halos can reflect features of cloud evolution, increase shortwave atmospheric radiative absorption, and may serve as a predominant region of new particle formation. We report results of an aircraft campaign off Oahu, Hawaii during August 2001, aimed at characterizing the humidity properties around isolated cumulus clouds at 10 m spatial resolution by a novel high-speed spectroscopic water vapor concentration monitor developed by Aerodyne Research, Inc. Analysis of the measurements adds to the existing body of information on cloud halos, their frequency of occurrence, spatial extent, and meteorological characteristics. The dynamic model RAMS (Regional Atmospheric Modeling System) in the LES (Large Eddy Simulation) mode and the SHDOM (Spherical Harmonic Discrete Ordinate Method) radiative transfer model have been implemented for one particularly long-lived cloud to track the temporal evolution of the cloud halos and to calculate the associated spatial and temporal patterns of shortwave absorption. Results of this modeling study are in general agreement with the field measurement data and previous aircraft studies.

  7. 2-D Animation's Not Just for Mickey Mouse.

    ERIC Educational Resources Information Center

    Weinman, Lynda

    1995-01-01

    Discusses characteristics of two-dimensional (2-D) animation; highlights include character animation, painting issues, and motion graphics. Sidebars present Silicon Graphics animations tools and 2-D animation programs for the desktop computer. (DGM)

  8. MAZE96. Generates 2D Input for DYNA NIKE & TOPAZ

    SciTech Connect

    Sanford, L.; Hallquist, J.O.

    1992-02-24

    MAZE is an interactive program that serves as an input and two-dimensional mesh generator for DYNA2D, NIKE2D, TOPAZ2D, and CHEMICAL TOPAZ2D. MAZE also generates a basic template for ISLAND input. MAZE has been applied to the generation of input data to study the response of two-dimensional solids and structures undergoing finite deformations under a wide variety of large deformation transient dynamic and static problems and heat transfer analyses.

  9. On 2D graphical representation of DNA sequence of nondegeneracy

    NASA Astrophysics Data System (ADS)

    Zhang, Yusen; Liao, Bo; Ding, Kequan

    2005-08-01

    Some two-dimensional (2D) graphical representations of DNA sequences have been given by Gates, Nandy, Leong and Mogenthaler, Randić, and Liao et al., which give visual characterizations of DNA sequences. In this Letter, we introduce a nondegeneracy 2D graphical representation of DNA sequence, which is different from Randić's novel 2D representation and Liao's 2D representation. We also present the nondegeneracy forms corresponding to the representations of Gates, Nandy, Leong and Mogenthaler.

  10. Generates 2D Input for DYNA NIKE & TOPAZ

    1996-07-15

    MAZE is an interactive program that serves as an input and two-dimensional mesh generator for DYNA2D, NIKE2D, TOPAZ2D, and CHEMICAL TOPAZ2D. MAZE also generates a basic template for ISLAND input. MAZE has been applied to the generation of input data to study the response of two-dimensional solids and structures undergoing finite deformations under a wide variety of large deformation transient dynamic and static problems and heat transfer analyses.

  11. 2d PDE Linear Symmetric Matrix Solver

    1983-10-01

    ICCG2 (Incomplete Cholesky factorized Conjugate Gradient algorithm for 2d symmetric problems) was developed to solve a linear symmetric matrix system arising from a 9-point discretization of two-dimensional elliptic and parabolic partial differential equations found in plasma physics applications, such as resistive MHD, spatial diffusive transport, and phase space transport (Fokker-Planck equation) problems. These problems share the common feature of being stiff and requiring implicit solution techniques. When these parabolic or elliptic PDE''s are discretized withmore » finite-difference or finite-element methods,the resulting matrix system is frequently of block-tridiagonal form. To use ICCG2, the discretization of the two-dimensional partial differential equation and its boundary conditions must result in a block-tridiagonal supermatrix composed of elementary tridiagonal matrices. The incomplete Cholesky conjugate gradient algorithm is used to solve the linear symmetric matrix equation. Loops are arranged to vectorize on the Cray1 with the CFT compiler, wherever possible. Recursive loops, which cannot be vectorized, are written for optimum scalar speed. For matrices lacking symmetry, ILUCG2 should be used. Similar methods in three dimensions are available in ICCG3 and ILUCG3. A general source containing extensions and macros, which must be processed by a pre-compiler to obtain the standard FORTRAN source, is provided along with the standard FORTRAN source because it is believed to be more readable. The pre-compiler is not included, but pre-compilation may be performed by a text editor as described in the UCRL-88746 Preprint.« less

  12. 2d PDE Linear Asymmetric Matrix Solver

    1983-10-01

    ILUCG2 (Incomplete LU factorized Conjugate Gradient algorithm for 2d problems) was developed to solve a linear asymmetric matrix system arising from a 9-point discretization of two-dimensional elliptic and parabolic partial differential equations found in plasma physics applications, such as plasma diffusion, equilibria, and phase space transport (Fokker-Planck equation) problems. These equations share the common feature of being stiff and requiring implicit solution techniques. When these parabolic or elliptic PDE''s are discretized with finite-difference or finite-elementmore » methods, the resulting matrix system is frequently of block-tridiagonal form. To use ILUCG2, the discretization of the two-dimensional partial differential equation and its boundary conditions must result in a block-tridiagonal supermatrix composed of elementary tridiagonal matrices. A generalization of the incomplete Cholesky conjugate gradient algorithm is used to solve the matrix equation. Loops are arranged to vectorize on the Cray1 with the CFT compiler, wherever possible. Recursive loops, which cannot be vectorized, are written for optimum scalar speed. For problems having a symmetric matrix ICCG2 should be used since it runs up to four times faster and uses approximately 30% less storage. Similar methods in three dimensions are available in ICCG3 and ILUCG3. A general source, containing extensions and macros, which must be processed by a pre-compiler to obtain the standard FORTRAN source, is provided along with the standard FORTRAN source because it is believed to be more readable. The pre-compiler is not included, but pre-compilation may be performed by a text editor as described in the UCRL-88746 Preprint.« less

  13. Ultrasonic 2D matrix PVDF transducer

    NASA Astrophysics Data System (ADS)

    Ptchelintsev, A.; Maev, R. Gr.

    2000-05-01

    During the past decade a substantial amount of work has been done in the area of ultrasonic imaging technology using 2D arrays. The main problems arising for the two-dimensional matrix transducers at megahertz frequencies are small size and huge count of the elements, high electrical impedance, low sensitivity, bad SNR and slower data acquisition rate. The major technological difficulty remains the high density of the interconnect. To solve these problems numerous approaches have been suggested. In the present work, a 24×24 elements (24 transmit+24 receive) matrix and a switching board were developed. The transducer consists of two 52 μm PVDF layers each representing a linear array of 24 elements placed one on the top of the other. Electrodes in these two layers are perpendicular and form the grid of 0.5×0.5 mm pitch. The layers are bonded together with the ground electrode being monolithic and located between the layers. The matrix is backed from the rear surface with an epoxy composition. During the emission, a linear element from the emitting layer generates a longitudinal wave pulse propagating inside the test object. Reflected pulses are picked-up by the receiving layer. During one transmit-receive cycle one transmit element and one receive element are selected by corresponding multiplexers. These crossed elements emulate a small element formed by their intersection. The present design presents the following advantages: minimizes number of active channels and density of the interconnect; reduces the electrical impedance of the element improving electrical matching; enables the transmit-receive mode; due to the efficient backing provides bandwidth and good time resolution; and, significantly reduces the electronics complexity. The matrix can not be used for the beam steering and focusing. Owing to this impossibility of focusing, the penetration depth is limited as well by the diffraction phenomena.

  14. A Planar Quantum Transistor Based on 2D-2D Tunneling in Double Quantum Well Heterostructures

    SciTech Connect

    Baca, W.E.; Blount, M.A.; Hafich, M.J.; Lyo, S.K.; Moon, J.S.; Reno, J.L.; Simmons, J.A.; Wendt, J.R.

    1998-12-14

    We report on our work on the double electron layer tunneling transistor (DELTT), based on the gate-control of two-dimensional -- two-dimensional (2D-2D) tunneling in a double quantum well heterostructure. While previous quantum transistors have typically required tiny laterally-defined features, by contrast the DELTT is entirely planar and can be reliably fabricated in large numbers. We use a novel epoxy-bond-and-stop-etch (EBASE) flip-chip process, whereby submicron gating on opposite sides of semiconductor epitaxial layers as thin as 0.24 microns can be achieved. Because both electron layers in the DELTT are 2D, the resonant tunneling features are unusually sharp, and can be easily modulated with one or more surface gates. We demonstrate DELTTs with peak-to-valley ratios in the source-drain I-V curve of order 20:1 below 1 K. Both the height and position of the resonant current peak can be controlled by gate voltage over a wide range. DELTTs with larger subband energy offsets ({approximately} 21 meV) exhibit characteristics that are nearly as good at 77 K, in good agreement with our theoretical calculations. Using these devices, we also demonstrate bistable memories operating at 77 K. Finally, we briefly discuss the prospects for room temperature operation, increases in gain, and high-speed.

  15. MODELING NON-PRECIPITATING CUMULUS CLOUDS AS FLOW-THROUGH-REACTOR TRANSFORMER AND VENTING TRANSPORTER OF MIXED LAYER POLLUTANTS

    EPA Science Inventory

    A simple diagnostic model of cumulus convective clouds is developed and used in a sensitivity study to examine the extent to which the rate of change of mixed and cloud layer pollutant concentration is influenced by vertical transport and chemical transformation processes occurri...

  16. Interaction between moist physics, cumulus parameterization and GCM grid spacing in simulations of midlatitude mesoscale convective systems

    NASA Astrophysics Data System (ADS)

    Anderson, C. J.; Posselt, D. J.; Arritt, R. W.

    2011-12-01

    We have examined the representation of MCSs in the NASA GEOS-5 GCM via simulations of the 1993 Midwest flood period. The 1993 Midwest flood period is well suited for evaluating the ability of climate models to simulate aggregate characteristics of midlatitude mesoscale convective systems (MCSs). During June-July 1993, MCSs were unusually frequent and unusually coherent in space. As a consequence, time average quantities have MCS signatures, and composites of MCSs can be constructed from a relatively brief data record. A suite of numerical experiments is conducted for the purpose of examining the relative importance of interactions between cumulus and moist physical parameterizations at different model horizontal grid spacings. We examine composites of simulated MCSs, and find that it is necessary, particularly as grid spacing is reduced from 1.0 to 0.25-degree, to properly represent the heating profiles created by the interaction between cumulus and moist physics parameterization. Reconfiguration of the cumulus parameterization results in an increase in the availability of cloud material to the grid scale moist physics parameterization, resulting in increased grid scale precipitation and less precipitation generated in the cumulus parameterization. This modification leads to improvement in the precipitation spatial autocorrelation and more realistic treatment of the distribution of midlatitude MCSs.

  17. Acute fasting decreases the expression of GLUT1 and glucose utilisation involved in mouse oocyte maturation and cumulus cell expansion.

    PubMed

    Han, Yingying; Yan, Jun; Zhou, Jinlian; Teng, Zhen; Bian, Fenghua; Guo, Meng; Mao, Guankun; Li, Junxia; Wang, Jianwei; Zhang, Meijia; Xia, Guoliang

    2012-01-01

    Acute fasting impairs meiotic resumption and glucose consumption in mouse cumulus cell and oocyte complexes (COCs). This study examines the effects of acute fasting on the regulation of glucose transporter 1 (GLUT1) expression and glucose consumption in oocyte maturation. Our results indicate that the restriction of glucose utilisation by 2-deoxyglucose (2-DG) mimicked the inhibitory effects of acute fasting on oocyte meiotic resumption and cumulus cell expansion, effects that were rescued by high glucose concentrations in the culture medium. GLUT1 protein levels were higher in cumulus cells compared with oocytes, and GLUT1 expression in COCs increased with FSH treatment in vitro. However, under acute fasting conditions, GLUT1 expression in COCs decreased and the response to FSH disappeared. Exposure to high glucose conditions (27.5mM and 55mM), significantly increased both glucose consumption and GLUT1 levels in COCs. Inhibition of GLUT1 function using an anti-GLUT1 antibody significantly inhibited FSH-induced oocyte meiotic resumption. Taken together, these results suggest that acute fasting decreases GLUT1 expression and glucose utilisation, inhibiting the processes of oocyte maturation and cumulus cell expansion. PMID:22697123

  18. Earth Science Microwave Remote Sensing at NASA's Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Kim, Edward; Busalacchi, Antonio J. (Technical Monitor)

    2000-01-01

    The Goddard Space Flight Center (GSFC) was established as NASA's first space flight center in 1959. Its 12,000 personnel are active in the Earth and space sciences, astronomy, space physics, tracking and communications. GSFC's mission is to expand our knowledge of the Earth and its environment, the solar system, and the universe through observations from space. The main Goddard campus is located in Greenbelt, Maryland, USA, just north of Washington, D.C. The Wallops Flight Facility (operational since 1945), located on the Atlantic coast of Virginia was consolidated with the Goddard Space Flight Center in 1982. Wallops is now NASA's principal facility for management and implementation of suborbital research programs, and supports a wide variety of airborne science missions as well. As the lead Center for NASA's Earth Science Enterprise (ESE)--a long-term, coordinated research effort to study the Earth as a global environmental system--GSFC scientists and engineers are involved in a wide range of Earth Science remote sensing activities. Their activities range from basic geoscience research to the development of instruments and technology for space missions, as well as the associated Calibration/Validation (Cal/Val) work. The shear breadth of work in these areas precludes an exhaustive description here. Rather, this article presents selected brief overviews of microwave-related Earth Science applications and the ground-based, airborne, and space instruments that are in service, under development, or otherwise significantly involving GSFC. Likewise, contributing authors are acknowledged for each section, but the results and projects they describe represent the cumulative efforts of many persons at GSFC as well as at collaborating institutions. For further information, readers are encouraged to consult the listed websites and references.

  19. Correlated Electron Phenomena in 2D Materials

    NASA Astrophysics Data System (ADS)

    Lambert, Joseph G.

    In this thesis, I present experimental results on coherent electron phenomena in layered two-dimensional materials: single layer graphene and van der Waals coupled 2D TiSe2. Graphene is a two-dimensional single-atom thick sheet of carbon atoms first derived from bulk graphite by the mechanical exfoliation technique in 2004. Low-energy charge carriers in graphene behave like massless Dirac fermions, and their density can be easily tuned between electron-rich and hole-rich quasiparticles with electrostatic gating techniques. The sharp interfaces between regions of different carrier densities form barriers with selective transmission, making them behave as partially reflecting mirrors. When two of these interfaces are set at a separation distance within the phase coherence length of the carriers, they form an electronic version of a Fabry-Perot cavity. I present measurements and analysis of multiple Fabry-Perot modes in graphene with parallel electrodes spaced a few hundred nanometers apart. Transition metal dichalcogenide (TMD) TiSe2 is part of the family of materials that coined the term "materials beyond graphene". It contains van der Waals coupled trilayer stacks of Se-Ti-Se. Many TMD materials exhibit a host of interesting correlated electronic phases. In particular, TiSe2 exhibits chiral charge density waves (CDW) below TCDW ˜ 200 K. Upon doping with copper, the CDW state gets suppressed with Cu concentration, and CuxTiSe2 becomes superconducting with critical temperature of T c = 4.15 K. There is still much debate over the mechanisms governing the coexistence of the two correlated electronic phases---CDW and superconductivity. I will present some of the first conductance spectroscopy measurements of proximity coupled superconductor-CDW systems. Measurements reveal a proximity-induced critical current at the Nb-TiSe2 interfaces, suggesting pair correlations in the pure TiSe2. The results indicate that superconducting order is present concurrently with CDW in

  20. Goddard Atmospheric Composition Data Center: Aura Data and Services in One Place

    NASA Technical Reports Server (NTRS)

    Leptoukh, G.; Kempler, S.; Gerasimov, I.; Ahmad, S.; Johnson, J.

    2005-01-01

    The Goddard Atmospheric Composition Data and Information Services Center (AC-DISC) is a portal to the Atmospheric Composition specific, user driven, multi-sensor, on-line, easy access archive and distribution system employing data analysis and visualization, data mining, and other user requested techniques for the better science data usage. It provides convenient access to Atmospheric Composition data and information from various remote-sensing missions, from TOMS, UARS, MODIS, and AIRS, to the most recent data from Aura OMI, MLS, HIRDLS (once these datasets are released to the public), as well as Atmospheric Composition datasets residing at other remote archive site.

  1. Advances in terrestrial physics research at NASA/Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Salomonson, Vincent V.

    1987-01-01

    Some past, current, and future terrestrial physics research activities at NASA/Goddard Space Flight Center are described. The uses of satellites and sensors, such as Tiros, Landsat, Nimbus, and SMMR, for terrestrial physics research are discussed. The spaceborne data are applicable for monitoring and studying vegetation, snow, and ice dynamics; geological features; soil moisture; water resources; the geoid of the earth; and the earth's magnetic field. Consideration is given to improvements in remote sensing systems and data records and the Earth Observing System sensor concepts.

  2. Goddard Space Flight Center: 1994 Maryland/GSFC Earth and Environmental Science Teacher Ambassador Program

    NASA Technical Reports Server (NTRS)

    Latham, James

    1995-01-01

    The Maryland/Goddard Space Flight Center (GSFC) Earth and Environmental Science Teacher Ambassador Program was designed to enhance classroom instruction in the Earth and environmental science programs in the secondary schools of the state of Maryland. In October 1992, more than 100 school system administrators from the 24 local Maryland school systems, the Maryland State Department of Education, and the University of Maryland met with NASA GSFC scientists and education officers to propose a cooperative state-wide secondary school science teaching enhancement initiative.

  3. Implementation of NASA Materials and Processes Requirements at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Powers, Charles E.

    2009-01-01

    This slide presentation reviews the history and current practices of the Materials Engineering Branch (MEB) at the Goddard Space Flight Center. Included in the presentation is a review of the general Materials and Processes (M&P) requirements in the NASA-STD-6016. The work that the Materials Engineering Branch does to support GSFC Projects is also reviewed. The Materials Engineering Branch capabilities are listed, the expertise that is available to GSFC projects is also listed. Included in the backup slides are forms that the MEB uses to identify the materials in the spacecraft under development.

  4. Storage Information Management System (SIMS) Spaceflight Hardware Warehousing at Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Kubicko, Richard M.; Bingham, Lindy

    1995-01-01

    Goddard Space Flight Center (GSFC) on site and leased warehouses contain thousands of items of ground support equipment (GSE) and flight hardware including spacecraft, scaffolding, computer racks, stands, holding fixtures, test equipment, spares, etc. The control of these warehouses, and the management, accountability, and control of the items within them, is accomplished by the Logistics Management Division. To facilitate this management and tracking effort, the Logistics and Transportation Management Branch, is developing a system to provide warehouse personnel, property owners, and managers with storage and inventory information. This paper will describe that PC-based system and address how it will improve GSFC warehouse and storage management.

  5. Effect of oocyte-secreted factors on porcine in vitro maturation, cumulus expansion and developmental competence of parthenotes.

    PubMed

    Gomez, Ma Ninia L; Kang, Jung Taek; Koo, Ok Jae; Kim, Su Jin; Kwon, Dae Kee; Park, Sol Ji; Atikuzzaman, Mohammad; Hong, So Gun; Jang, Goo; Lee, Byeong Chun

    2012-05-01

    The oocyte is known from recent studies in the mouse, cow, sheep and human to be a central regulator of follicular cell function. However, in the pig, little information is known about the regulation of cumulus expansion by oocyte-secreted factors and oocyte quality. We investigated the possible effects of oocyte-secreted factors during in vitro maturation on cumulus expansion and on porcine oocytes as judged by subsequent embryonic development after parthenogenetic activation. Cumulus-oocyte complexes (COC) from antral follicles of pig ovaries collected from a local abattoir were divided into control and treatment groups and were cultured in tissue culture medium 199 supplemented with follicle-stimulating hormone. Treatment groups consisted of increasing numbers of denuded oocytes (DO) co-cultured with COC (at ratios of COC to DO of 1:1, 1:2, 1:3, 1:4 and 1:5). After incubation for 44 h, cumulus expansion and maturation rates were assessed and oocytes were activated parthenogenetically. Cumulus expansion in the 1 COC:4 DO and 1 COC:5 DO groups was low and altered because full dispersion of the outer layer did not occur. Cell viability was not affected, as measured by the automated cell counter, but scanning electron microscopy revealed only a scanty extracellular matrix. Blastocyst rate was significantly higher in the 1 COC:4 DO (34.4%) and in the 1 COC:5 DO (34.9%) groups (p < 0.05) when compared with other groups. Maturation rate, cleavage rate and total cell number showed no significant difference between control and treatment groups. Amplification by reverse transcription polymerase chain reaction (RT-PCR) showed up-regulation of growth differentiation factor 9 (GDF9) in the cumulus cells in the 1 COC:4 DO group at 44 h. We conclude that denuded porcine oocytes could improve the maturation of COC as evidenced by increased blastocyst development in the 1 COC:4 DO, even though cumulus expansion was poor. This improvement could be a result of the GDF9 up

  6. Stochastic and scale-adaptive shallow cumulus parameterization (EDMF-DualM-S in ICON)

    NASA Astrophysics Data System (ADS)

    Sakradzija, M.; Seifert, A.; Heus, T.; Dipankar, A.

    2014-12-01

    Numerical cloud-resolving studies of cumulus clouds reveal the small-scale variability of convection that is not fully controlled by the large scale environment. From the parameterization point of view, this means that there is a whole distribution of the sub-grid convective states that can correspond to the same large scale forcing. Moreover, the stochastic variability becomes higher with the increasing model resolution. As the cloud sample within a model grid box becomes smaller, the most probable realization of the sub-grid convection deviates further away from the convective ensemble mean. Therefore, as the atmospheric models approach higher and higher resolution, it becomes more important to develop stochastic schemes that sub-sample the convective cloud ensemble and adapt to the model resolution. We propose an approach to represent the stochastic variability of the unresolved shallow-convective states, and the dependence of the distribution of sub-grid states on the model horizontal resolution. We combine the theory of fluctuations in a convective ensemble based on a statistical mechanics approach and Large-Eddy Simulation (LES) of shallow cumulus clouds of an idealized case over the ocean. Based on the empirical and theoretical findings, a stochastic cloud generator is developed and coupled to the EDMF-DualM cloud scheme in the ICON model as a stochastic process that runs simultaneously with the EDMF scheme. The stochastic scheme adds more complexity to the cloud parameterization in EDMF, but on the other side, the cloud mass flux profiles are locally sampled instead of using the buoyancy sorting closure for the bulk vertical profile. The scheme also relaxes the statistical equilibrium assumption by applying it only at the scale at which it is appropriate and by including the memory component. Preliminary results show that the variability is well reproduced and that the scheme is scale-adaptive. Impact on the mean profiles is small, except for a significant

  7. Inertial stability, cumulus momentum transport, and the genesis of tropical plumes

    NASA Astrophysics Data System (ADS)

    Mecikalski, John Robert

    Tropical plumes are identified in satellite data as elongated cloud bands originating from convective activity along the Intertropical Convergence Zone (ITCZ), often extending far into middle latitudes. Many previous studies consider tropical plumes as a product of quasigeostrophic forcing. We consider the view that tropical plumes are the upper branch of an enhanced thermally direct circulation, driven by latent heat release in deep cumulus convection, and by processes tied to low inertial stability. As low potential vorticity ( PV) ridges over and straddles the ITCZ, in the amplifying flow in advance of an intruding large-scale Rossby wave, plume genesis occurs. As low PV advects across the ITCZ, the meridional inertial stability gradient equilibrates or reverses. Under these conditions, the work requirements of deep ITCZ convection to spread its outflow and force compensating subsidence ease. The diagnostic parameter ``inertial available kinetic energy'' (IAKE), developed as part of this study, reveals much reduced upper tropospheric inertial stability in conjunction with tropical plume genesis. With a vertical transport of easterly momentum by convection, IAKE becomes positive as convectively-generated (negative) PV lowers inertial stability poleward of the ITCZ as a convection-relative inertial instability forms. Westerly momentum transported vertically to cloud top, in contrast, results in the equatorward-direction the more favored direction for cumulonimbus outflow aloft. The combination of cumulus momentum transport within an environment characterized by low inertial stability causes ITCZ convective outflow to locally and abruptly switch to intensified poleward flows as tropical plumes. Working from these diagnostic conclusions, a numerical experiment to determine whether ambient inertial stability causes deep convection across the plume genesis region to physically align their internal flow structure is undertaken. This structural alignment results in

  8. CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6*15 and *35 Genotyping

    PubMed Central

    Riffel, Amanda K.; Dehghani, Mehdi; Hartshorne, Toinette; Floyd, Kristen C.; Leeder, J. Steven; Rosenblatt, Kevin P.; Gaedigk, Andrea

    2016-01-01

    TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the presence of two pseudogenes, CYP2D7 and CYP2D8, structural and copy number variation and numerous single nucleotide polymorphisms (SNPs) some of which reflect the wild-type sequence of the CYP2D7 pseudogene. The aim of this study was to identify the mechanism causing false-positive CYP2D6*15 calls and remediate those by redesigning and validating alternative TaqMan genotype assays. Among 13,866 DNA samples genotyped by the CompanionDx® lab on the OpenArray platform, 70 samples were identified as heterozygotes for 137Tins, the key SNP of CYP2D6*15. However, only 15 samples were confirmed when tested with the Luminex xTAG CYP2D6 Kit and sequencing of CYP2D6-specific long range (XL)-PCR products. Genotype and gene resequencing of CYP2D6 and CYP2D7-specific XL-PCR products revealed a CC>GT dinucleotide SNP in exon 1 of CYP2D7 that reverts the sequence to CYP2D6 and allows a TaqMan assay PCR primer to bind. Because CYP2D7 also carries a Tins, a false-positive mutation signal is generated. This CYP2D7 SNP was also responsible for generating false-positive signals for rs769258 (CYP2D6*35) which is also located in exon 1. Although alternative CYP2D6*15 and *35 assays resolved the issue, we discovered a novel CYP2D6*15 subvariant in one sample that carries additional SNPs preventing detection with the alternate assay. The frequency of CYP2D6*15 was 0.1% in this ethnically diverse U.S. population sample. In addition, we also discovered linkage between the CYP2D7 CC>GT dinucleotide SNP and the 77G>A (rs28371696) SNP of CYP2D6*43. The frequency of this tentatively functional allele was 0.2%. Taken together, these findings emphasize that regardless of how careful genotyping assays are designed and evaluated before being commercially marketed, rare or unknown SNPs underneath primer and/or probe regions can impact

  9. CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6 (*) 15 and (*) 35 Genotyping.

    PubMed

    Riffel, Amanda K; Dehghani, Mehdi; Hartshorne, Toinette; Floyd, Kristen C; Leeder, J Steven; Rosenblatt, Kevin P; Gaedigk, Andrea

    2015-01-01

    TaqMan™ genotyping assays are widely used to genotype CYP2D6, which encodes a major drug metabolizing enzyme. Assay design for CYP2D6 can be challenging owing to the presence of two pseudogenes, CYP2D7 and CYP2D8, structural and copy number variation and numerous single nucleotide polymorphisms (SNPs) some of which reflect the wild-type sequence of the CYP2D7 pseudogene. The aim of this study was to identify the mechanism causing false-positive CYP2D6 (*) 15 calls and remediate those by redesigning and validating alternative TaqMan genotype assays. Among 13,866 DNA samples genotyped by the CompanionDx® lab on the OpenArray platform, 70 samples were identified as heterozygotes for 137Tins, the key SNP of CYP2D6 (*) 15. However, only 15 samples were confirmed when tested with the Luminex xTAG CYP2D6 Kit and sequencing of CYP2D6-specific long range (XL)-PCR products. Genotype and gene resequencing of CYP2D6 and CYP2D7-specific XL-PCR products revealed a CC>GT dinucleotide SNP in exon 1 of CYP2D7 that reverts the sequence to CYP2D6 and allows a TaqMan assay PCR primer to bind. Because CYP2D7 also carries a Tins, a false-positive mutation signal is generated. This CYP2D7 SNP was also responsible for generating false-positive signals for rs769258 (CYP2D6 (*) 35) which is also located in exon 1. Although alternative CYP2D6 (*) 15 and (*) 35 assays resolved the issue, we discovered a novel CYP2D6 (*) 15 subvariant in one sample that carries additional SNPs preventing detection with the alternate assay. The frequency of CYP2D6 (*) 15 was 0.1% in this ethnically diverse U.S. population sample. In addition, we also discovered linkage between the CYP2D7 CC>GT dinucleotide SNP and the 77G>A (rs28371696) SNP of CYP2D6 (*) 43. The frequency of this tentatively functional allele was 0.2%. Taken together, these findings emphasize that regardless of how careful genotyping assays are designed and evaluated before being commercially marketed, rare or unknown SNPs underneath primer

  10. Follicle-stimulating hormone-induced rescue of cumulus cell apoptosis and enhanced development ability of buffalo oocytes.

    PubMed

    Jain, A; Jain, T; Kumar, P; Kumar, M; De, S; Gohain, M; Kumar, R; Datta, T K

    2016-04-01

    The effect of follicle-stimulating hormone (FSH) on apoptotic status of cumulus cells, expression of proapoptotic and antiapoptotic genes, and development rate of in vitro fertilization-produced buffalo embryos were investigated. FSH supplementation in in vitro maturation-medium resulted in a dose-dependent reduction in the expression of proapoptotic genes namely, BCL2-associated X protein (BAX), cytochrome c, and caspase-3 and increase in the expression of antiapoptotic genes such as B-cell lymphoma 2 (BCL2) and X-linked inhibitor of apoptosis protein (XIAP) in cumulus cells of mature oocyte. Cumulus expansion, oocyte maturation, cleavage, and blastocyst development rates were significantly higher (P < 0.05) in 5 and 10-μg/mL FSH-supplemented groups as compared with control. Significant increase in the expression of FSH receptor messenger RNA was also found with 5 and 10-μg/mL FSH (P < 0.05). Terminal deoxynucleotidyl transferase dUTP nick end labeling assay confirmed that the population of apoptotic cumulus cells of matured oocytes was reduced in the FSH-treated groups as compared with control (P < 0.05). In conclusion, our data suggest that FSH may attenuate apoptosis in cumulus cells via mitochondria-dependent apoptotic pathway by increasing XIAP expression, resulting in a more favorable ratio of BCL2/BAX expression and decreasing the cytochrome c and caspase-3 expression, eventually contributing to developmental competence of oocytes. The information generated will help in improving the in vitro embryo production program in buffalo. PMID:26774556

  11. Mean and Turbulence Structure of the Shallow Cumulus-topped Boundary Layers in the DYNAMO Measurement Domain

    NASA Astrophysics Data System (ADS)

    Alappattu, D. P.; Wang, Q.; Khelif, D.

    2013-12-01

    Abstract: Extensive measurements were collected using NOAA's WP-3D Orion aircraft (P3) on 19 November 2011 over the Topical Indian Ocean (TIO; 8E-EQ and 72E-81E) as a part of DYNAMO (Dynamics of Madden Julian Oscillation) field campaign. On this mission P3 conducted five vertically stacked level legs each having 4-5 levels of measurements. Boundary layer profiling also performed after each vertically stacked leg. A total of 6 hour 18 minutes of high frequency (25 Hz) data of temperature, humidity and three components of wind were collected. Sea surface temperature (SST) and liquid water content also were measured. Average sampling levels of the vertically stacked legs were at 60 m, 120 m, 350 m, 475 m and 650 m. The lowest three levels were well inside the boundary layer while the next two levels were at the cloud base and within the cloud respectively. Aircraft penetrated through a minimum of one trade wind cumulus in each vertically stacked leg. A few of the observed trade wind cumuli were precipitating during the measurements. The case to be presented is the only flight were shallow precipitating cumulus clouds were sampled intensively before the active phase of the November MJO event. We will discuss the mean vertical structure and the horizontal variability of this cumulus-topped boundary layer. Fluxes of momentum, sensible heat and latent heat estimated using the eddy correlation method will be presented to illustrate the energy and water vapor transport in this type of boundary layer in the DYNAMO domain. Variation of drag coefficient and heat exchange coefficients with wind speed is also presented. Spectral analysis performed on the data will reveal the dominant turbulent eddy size in the presence of cumulus clouds. Finally, we will discuss the observed differences in vertical velocity, buoyancy and entrainment/detrainment eddy fluxes in the precipitating and non-precipitating cumulus clouds.

  12. Effects of aspiration vacuum and needle diameter on cumulus oocyte complex morphology and developmental capacity of bovine oocytes.

    PubMed

    Bols, P E; Van Soom, A; Ysebaert, M T; Vandenheede, J M; de Kruif, A

    1996-04-01

    The effects of aspiration vacuum and needle diameter on the morphology of the cumulusoocyte-complex (COC) and developmental capacity of the oocyte after IVF was studied in 2 experiments using a disposable ovum pick-up needle guidance system whose construction permits its use in vitro. In Experiment 1, the relationship was determined between the aspiration vacuum, expressed in millimetre of mercury, and the actual amount of water aspirated by the system, expressed in millilitre per minute. In Experiment 2, five different levels of aspiration vacuum for 3 different needle diameters (18g, 19g and 21g) were tested in slaughterhouse ovaries. The cumulus-oocyte complexes (COCs) were divided into 3 categories: 1) oocytes with a compact cumulus, 2) oocytes with an expanded cumulus and 3) naked oocytes. The results show that a change of needle diameter can triple the amount of fluid actually aspirated. The highest oocyte recovery rates are obtained when using the thickest needle (18-g), regardless of the aspiration vacuum. On the average, for all needle types, more oocytes are recovered at the highest aspiration vacuum. For all needle diameters, the proportion of oocytes surrounded by a compact cumulus decreases progressively as the vacuum increases. Regardless of the vacuum applied, thinner needles result in a higher proportion of recovered COCs with a compact cumulus. At a high aspiration vacuum, naked oocytes become predominant regardless of the needle diameter. The prevalence of blastocysts, expressed in proportion to the recovered COCs, decreases as the aspiration vacuum increases, being especially noticeable between 70 and 130 mm Hg. PMID:16727859

  13. Effects of Vitrification on Immature and in vitro Matured, Denuded and Cumulus Compact Goat Oocytes and Their Subsequent Fertilization

    PubMed Central

    Purohit, Govind Narayan; Meena, Harikesh; Solanki, Kanika

    2012-01-01

    Background Vitrification has proven to be more effective than slow freezing methods to cryopreserve mammalian oocytes. The objectives of this study were to evaluate the effects of vitrification on immature and in vitro matured, denuded and cumulus compact goat oocytes and their subsequent fertilization. Methods Oocytes were either cryopreserved as immature cumulus compact (IMCC) (n=98 Exp 1; 102 Exp 2) and immature denuded (IMDN) (n=127 Exp 1; 109 Exp 2) or were first matured in vitro for 28 h and then cryopreserved as mature cumulus compact (MCC) (n=109 Exp 1; 89 Exp 2) or mature denuded (MDN) (n=112 Exp 1; 110 Exp 2) oocytes in four groups. The vitrification solution comprised of Dulbecco's phosphate buffered saline supplemented with 0.5% sucrose, 0.4% bovine serum albumin and 8 M propylene glycol. After 7 days of cryopreservation in liquid nitrogen, oocytes in all groups were evaluated for normal morphologic survival and in vitro maturation (Experiment 1) and fertilization in vitro using epididymal buck spermatozoa (Experiment 2). Results The number of oocytes retaining normal morphology was significantly higher (p <0.05) for cumulus compact oocytes (IMCC: 94.12% vs. IMDN: 89.22%, experiment 1 and MCC: 87.80% vs. MDN: 82.17%, experiment 2) compared to the denuded oocytes. The in vitro maturation of oocytes was highest for non-vitrified control oocytes. The maturation of vitrified IMCC oocytes was significantly higher than IMDN and their fertilizability was higher than MCC and MDN oocytes. Conclusion The results suggest that immature cumulus compact goat oocytes better tolerate cryopreservation stress by vitrification in terms of fertilization rate. PMID:23926524

  14. Embryonic Poly(A)-Binding Protein (EPAB) Is Required for Granulosa Cell EGF Signaling and Cumulus Expansion in Female Mice.

    PubMed

    Yang, Cai-Rong; Lowther, Katie M; Lalioti, Maria D; Seli, Emre

    2016-01-01

    Embryonic poly(A)-binding protein (EPAB) is the predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos before zygotic genome activation. EPAB is required for translational activation of maternally stored mRNAs in the oocyte and Epab(-/-) female mice are infertile due to impaired oocyte maturation, cumulus expansion, and ovulation. The aim of this study was to characterize the mechanism of follicular somatic cell dysfunction in Epab(-/-) mice. Using a coculture system of oocytectomized cumulus oophorus complexes (OOXs) with denuded oocytes, we found that when wild-type OOXs were cocultured with Epab(-/-) oocytes, or when Epab(-/-) OOXs were cocultured with WT oocytes, cumulus expansion failed to occur in response to epidermal growth factor (EGF). This finding suggests that oocytes and cumulus cells (CCs) from Epab(-/-) mice fail to send and receive the necessary signals required for cumulus expansion. The abnormalities in Epab(-/-) CCs are not due to lower expression of the oocyte-derived factors growth differentiation factor 9 or bone morphogenetic protein 15, because Epab(-/-) oocytes express these proteins at comparable levels with WT. Epab(-/-) granulosa cells (GCs) exhibit decreased levels of phosphorylated MEK1/2, ERK1/2, and p90 ribosomal S6 kinase in response to lutenizing hormone and EGF treatment, as well as decreased phosphorylation of the EGF receptor. In conclusion, EPAB, which is oocyte specific, is required for the ability of CCs and GCs to become responsive to LH and EGF signaling. These results emphasize the importance of oocyte-somatic communication for GC and CC function. PMID:26492470

  15. Molecular signature in human cumulus cells related to embryonic developmental potential.

    PubMed

    Xu, Xiaofeng; Chen, Dawei; Zhang, Zhiguo; Wei, Zhaolian; Cao, Yunxia

    2015-02-01

    Identification of criteria for embryo quality is required to improve the clinical outcome of in vitro fertilization. The aim of this study was to determine the gene expression profile of cumulus cells (CC) surrounding the oocyte as biomarkers for embryonic developmental potential. CCs from single oocytes were analysed using DNA microarrays. Gene expression profiles of CC surrounding the oocyte associated with good embryonic quality were analyzed. We observed that CCs issued from oocytes that developed into embryos with a good morphology had significantly different gene expression profile from those with bad morphology. These results were confirmed by quantitative RT-PCR. The gene expression profiling of human CC correlates with embryo potential. Our findings suggest anon-invasive approach, offering a new potential strategy for competent embryo selection. PMID:24899471

  16. C-type natriuretic peptide improved vitrified-warmed mouse cumulus oocyte complexes developmental competence.

    PubMed

    Yang, Lei; Wei, Qiang; Li, Wei; Ge, Junbang; Zhao, Xiaoe; Ma, Baohua

    2016-04-01

    Cryopreservation of cumulus oocyte complexes (COCs) is important for reproductive medicine. However, the vitrified-warmed COCs have lower maturation rate and subsequent developmental competence compared with fresh COCs. The present study was aimed to evaluate the effects of supplementation of the maturation medium with C-type natriuretic peptide (CNP) on the developmental competence of vitrified-warmed mouse COCs. Addition of CNP to the maturation medium improved the maturation rate and enhanced the developmental competence of vitrified-warmed mouse COCs. The reason may be that vitrified COCs led to a decline in cyclic guanosine monophosphate (cGMP) levels. Furthermore, addition of CNP to the maturation medium elevated cGMP levels of the vitrified-warmed COCs. In conclusion, cryopreservation-associated lower maturation rate and developmental competence of COCs may be ameliorated by CNP during maturation culture after warming. PMID:26921772

  17. Observational evidence for aerosol invigoration in shallow cumulus downstream of Mount Kilauea

    NASA Astrophysics Data System (ADS)

    Mace, G. G.; Abernathy, A. C.

    2016-03-01

    Knowledge of how marine boundary layer (MBL) shallow cumulus clouds respond to changes in aerosol is central to understanding how MBL clouds modulate the climate system. Mount Kilauea on the island of Hawaii began erupting in 2008 injecting substantial SO2 into the marine boundary layer creating a unique natural laboratory. Examining data from approximately 600 passes of the A-Train downstream of Mount Kilauea over a 3 year period and separating data into aerosol optical depth quartiles, we find an unambiguous increase in marine boundary cloud top height and an increase in surface wind speed as aerosol increases while the radar reflectivity does not change substantially. We conclude that increased aerosols may have caused invigoration of the MBL clouds. Additionally, we find that increases in sub 1 km cloud fraction combined with increasing aerosol explain the increased visible reflectance suggesting that evidence for the so-called first aerosol indirect effect should be reexamined.

  18. Stratocumulus to cumulus transition in the presence of elevated smoke layers

    NASA Astrophysics Data System (ADS)

    Yamaguchi, Takanobu; Feingold, Graham; Kazil, Jan; McComiskey, Allison

    2015-12-01

    The transition from stratocumulus to cumulus clouds in the presence of elevated light-absorbing smoke layers is investigated with idealized large-eddy simulations. A smoke layer is placed 1 km above stratocumulus top and evolves with the cloud fields over the course of a 3 day simulation. The simulations presented vary the smoke-generated heating and the moisture content of the smoke layer. A control case without smoke is simulated for comparison. On day 2 of the transition, when still above cloud, smoke generates a more broken cloud field than the control case, depending weakly on the strength of the aerosol heating but strongly on the water vapor content in the smoke layer. Following nighttime recovery and contact with the stratocumulus, smoke hinders the transition by strengthening the inversion, limiting boundary layer deepening and reducing precipitation-related breakup. This modulation delays the transition, which may extend the stratocumulus deck westward, with concomitant implications for climate forcing.

  19. Measurements of cloud condensation nuclei spectra within maritime cumulus cloud droplets: Implications for mixing processes

    NASA Technical Reports Server (NTRS)

    Twohy, Cynthia H.; Hudson, James G.

    1995-01-01

    In a cloud formed during adiabatic expansion, the droplet size distribution will be systematically related to the critical supersaturation of the cloud condensation nuclei (CNN), but this relationship can be complicated in entraining clouds. Useful information about cloud processes, such as mixing, can be obtained from direct measurements of the CNN involved in droplet nucleation. This was accomplished by interfacing two instruments for a series of flights in maritime cumulus clouds. One instrument, the counterflow virtual impactor, collected cloud droplets, and the nonvolatile residual nuclei of the droplets was then passed to a CCN spectrometer, which measured the critical supersaturation (S(sub c)) spectrum of the droplet nuclei. The measured S(sub c) spectra of the droplet nuclei were compared with the S(sub c) spectra of ambient aerosol particles in order to identify which CCN were actually incorporated into droplets and to determine when mixing processes were active at different cloud levels. The droplet nuclei nearly always exhibited lower median S(sub c)'s than the ambient aerosol, as expected since droplets nucleate perferentially on particles with lower critical supersaturations. Critical supersaturation spectra from nuclei of droplets near cloud base were similar to those predicted for cloud regions formed adiabatically, but spectra of droplet nuclei from middle cloud levels showed some evidence that mixing had occurred. Near cloud top, the greatest variation in the spectra of the droplet nuclei was observed, and nuclei with high S(sub c)'s were sometimes present even within relatively large droplets. This suggests that the extent of mixing increases with height in cumulus clouds and that inhomogeneous mixing may be important near cloud top. These promising initial results suggest improvements to the experimental technique that will permit more quantitative results in future experiments.

  20. Direct Numerical Simulation of Evaporative Cooling at the Lateral Boundary of Shallow Cumulus Clouds

    NASA Astrophysics Data System (ADS)

    Heus, T.; Abma, D.; Mellado, J.

    2012-12-01

    This study investigates the dynamics of a narrow region of subsiding air at the lateral boundary of cumulus clouds, focusing on the role of evaporative cooling. Previous observational and large-eddy simulations showed the relevance of this subsiding shell in cloud dynamics, but have also showed that the size of this shell is well below what large-eddy simulations can resolve. Therefore, we have performed direct numerical simulations of an idealized subsiding shell to investigate accurately the complete turbulent field. The system develops a self-similar, Reynolds number independent flow which allows for the determination of explicit scaling laws relating the characteristic length, time and velocity scales of the shell. In particular, it is found that the shell width grows quadratically in time, and linearly with decreasing height. The magnitude of these growth rates confirm the importance of the subsiding shell because of the relatively fast development of entrainment-determining scales: for typical thermodynamic conditions in cumulus clouds, a velocity of the order of 1~m~s-1 and a thickness of the order of 10 meters are established in about 2 minutes. This fits well within the typical cloud life time, suggesting that our idealization is an adequate framework for the analysis of relevant aspects in the subsiding shell associated with buoyancy reversal. It also indicates that the scaling laws derived here can be used to estimate the potential strength of a subsiding shell and the mean lateral entrainment associated with it, provided an estimate of the local thermodynamical state of the cloud boundary. It is shown that the dominant parameter of this system is the saturation buoyancy, whereas the effect of the saturation mixing fraction is minor.uoyancy field in the subsiding shell. Blue colors are low values, red colors are high values.

  1. Investigation of Aerosol Indirect Effects using a Cumulus Microphysics Parameterization in a Regional Climate Model

    SciTech Connect

    Lim, Kyo-Sun; Fan, Jiwen; Leung, Lai-Yung R.; Ma, Po-Lun; Singh, Balwinder; Zhao, Chun; Zhang, Yang; Zhang, Guang; Song, Xiaoliang

    2014-01-29

    A new Zhang and McFarlane (ZM) cumulus scheme includes a two-moment cloud microphysics parameterization for convective clouds. This allows aerosol effects to be investigated more comprehensively by linking aerosols with microphysical processes in both stratiform clouds that are explicitly resolved and convective clouds that are parameterized in climate models. This new scheme is implemented in the Weather Research and Forecasting (WRF) model, which is coupled with the physics and aerosol packages from the Community Atmospheric Model version 5 (CAM5). A test case of July 2008 during the East Asian summer monsoon is selected to evaluate the performance of the new ZM scheme and to investigate aerosol effects on monsoon precipitation. The precipitation and radiative fluxes simulated by the new ZM scheme show a better agreement with observations compared to simulations with the original ZM scheme that does not include convective cloud microphysics and aerosol convective cloud interactions. Detailed analysis suggests that an increase in detrained cloud water and ice mass by the new ZM scheme is responsible for this improvement. To investigate precipitation response to increased anthropogenic aerosols, a sensitivity experiment is performed that mimics a clean environment by reducing the primary aerosols and anthropogenic emissions to 30% of that used in the control simulation of a polluted environment. The simulated surface precipitation is reduced by 9.8% from clean to polluted environment and the reduction is less significant when microphysics processes are excluded from the cumulus clouds. Ensemble experiments with ten members under each condition (i.e., clean and polluted) indicate similar response of the monsoon precipitation to increasing aerosols.

  2. Investigation of the Gamma Distribution Shape Parameter in Shallow Cumulus Clouds

    NASA Astrophysics Data System (ADS)

    Igel, A. L.; van den Heever, S. C.

    2014-12-01

    Many bulk microphysics parameterizations assume that the droplet size distribution (DSD) of hydrometeor species such as cloud water and rain water conform to a gamma probability distribution function (PDF). Such an assumption is necessary in order to simplify the description of microphysical processes in such bulk parameterizations. The gamma PDF has a parameter that influences the width of the distribution that is commonly referred to as the shape parameter. In one- and two-moment bulk microphysics schemes, this parameter is often arbitrarily set to a fixed value throughout the simulation. This is in part due to limited observations of the shape parameter. While many studies have sought to understand this parameter for rain, few studies examine this parameter for cloud droplets. In this study, we use high-resolution simulations of shallow cumulus clouds with a spectral bin representation of the hydrometeor species to find best-fit parameters of the gamma PDF to the predicted cloud DSDs. These simulations reveal that the cloud shape parameter is high in the supersaturated regions of the cloud and low in regions where the cloud water is evaporating. Values many times higher than the standard values of 1-4 are not uncommon in the bin simulations. The results of this analysis are used to suggest appropriate values of the cloud shape parameter in simulations employing a bulk microphysics scheme. The sensitivity of cloud properties, dynamics, and rainfall to the cloud shape parameter are investigated in simulations in which the parameter is fixed. Conclusions about the importance of choosing an appropriate cloud shape parameter for simulating cumulus clouds in climate or weather models are drawn.

  3. Distribution of cortical granules in bovine oocytes classified by cumulus complex.

    PubMed

    Hosoe, M; Shioya, Y

    1997-11-01

    The present study was conducted to examine distributional changes of cortical granules (CGs) during meiotic maturation and fertilisation in vitro and the developmental ability in bovine oocytes classified by cumulus cells. The oocytes were classified by the morphology of their cumulus cell layers as follows: class A, compact and thick; class B, compact but thin; class C, naked; and class D, expanded. Some of the oocytes were stained with Lens curinalis agglutinin (LCA) before and after maturation in vitro and after insemination, and then stained with orcein to observe their nuclear stages. The others were left in culture. Distributional patterns of the CGs were classified into four types: type I, CGs distributed in clusters; type II, CGs dispersed and partly clustered; type III, all CGs dispersed; and type IV, no CGs. Most of the oocytes before culture showed a type I pattern, but this decreased after maturation culture, whereas type III increased in class A. The oocytes of class B showed similar changes while the oocytes of class C did not. In class C, many oocytes showed type I after culture, indicating that cytoplasmic maturation was not completed. In class D, 80.4% of the oocytes exhibited type III before maturation culture, indicating that their cytoplasmic maturation was different from classes A-C. And about 70% of the class D oocytes were at the nuclear stage of germinal vesicle breakdown (GVBD) before culture. The developmental rates to blastocysts in classes A-D were 28.7%, 23.1%, 0.5% and 3.4% respectively. PMID:9563685

  4. Improving Forecasts of Cumulus: An Intersection of the Renewable Energy and Climate Science Communities

    NASA Astrophysics Data System (ADS)

    Berg, L. K.; Gustafson, W. I., Jr.; Kassianov, E.; Long, C. N.

    2015-12-01

    Accurate forecasts of broken cloud fields and their associated impact on the downwelling solar irradiance has remained a challenge to the renewable energy industry. Likewise, shallow cumulus play an important role in the Earth's radiation budget and hydrologic cycle and are of interest to the weather forecasting and climate science communities. The main challenge associated with predicting these clouds are their relatively small size (on the order of a kilometer or less) relative to the model grid spacing. Recently, however, there have been significant efforts put into improving forecasts of shallow clouds and the associated temporal and spatial variability of the solar irradiance that they induce. As an example of these efforts, we will describe recent modifications to the standard Kain-Fritsch parameterization as applied within the Weather Research and Forecasting (WRF) model that are designed to improve predictions of the macroscale and microscale structure of shallow cumulus. These modifications are shown to lead to a realistic increase in the simulated cloud fraction and associated decrease in the solar irradiance. We will evaluate our results using data collected at the Department of Energy's Atmospheric Radiation Measurement (ARM) Southern Great Plains site, which is located in north-central Oklahoma. Our team has analyzed over 5 years of data collected at this site to document the macroscale structure of the clouds (including cloud fraction, cloud-base and cloud-top height) as well as their impact on the downwelling shortwave and longwave irradiance. One particularly interesting impact of shallow cumuli is the enhancement of the diffuse radiation, such that during periods in which the sun is not blocked, the observed irradiance can be significantly larger than the corresponding clear sky case. To date, this feature is not accurately represented by models that apply the plane-parallel assumption applied in the standard radiation parameterizations.

  5. Absence of cumulus cells during in vitro maturation affects lipid metabolism in bovine oocytes.

    PubMed

    Auclair, Sylvain; Uzbekov, Rustem; Elis, Sébastien; Sanchez, Laura; Kireev, Igor; Lardic, Lionel; Dalbies-Tran, Rozenn; Uzbekova, Svetlana

    2013-03-15

    Cumulus cells (CC) surround the oocyte and are coupled metabolically through regulation of nutrient intake. CC removal before in vitro maturation (IVM) decreases bovine oocyte developmental competence without affecting nuclear meiotic maturation. The objective was to investigate the influence of CC on oocyte cytoplasmic maturation in relation to energy metabolism. IVM with either cumulus-enclosed (CEO) or -denuded (DO) oocytes was performed in serum-free metabolically optimized medium. Transmission electron microscopy revealed different distribution of membrane-bound vesicles and lipid droplets between metaphase II DO and CEO. By Nile Red staining, a significant reduction in total lipid level was evidenced in DO. Global transcriptomic analysis revealed differential expression of genes regulating energy metabolism, transcription, and translation between CEO and DO. By Western blot, fatty acid synthase (FAS) and hormone-sensitive phospholipase (HSL) proteins were detected in oocytes and in CC, indicating a local lipogenesis and lypolysis. FAS protein was significantly less abundant in DO that in CEO and more highly expressed in CC than in the oocytes. On the contrary, HSL protein was more abundant in oocytes than in CC. In addition, active Ser⁵⁶³-phosphorylated HSL was detected in the oocytes only after IVM, and its level was similar in CEO and DO. In conclusion, absence of CC during IVM affected lipid metabolism in the oocyte and led to suboptimal cytoplasmic maturation. Thus, CC may influence the oocyte by orienting the consumption of nutritive storage via regulation of local fatty acid synthesis and lipolysis to provide energy for maturation. PMID:23321473

  6. Glucocorticoid metabolism in the bovine cumulus-oocyte complex matured in vitro.

    PubMed

    Tetsuka, Masafumi; Takagi, Ryo; Ambo, Nobuhiro; Myat, Thet Su; Zempo, Yuta; Onuma, Asuka

    2016-01-01

    Glucocorticoid action in target organs is regulated by relative activities of 11β-HSD type 1 (HSD11B1) that mainly converts cortisone to active cortisol and type 2 (HSD11B2) that inactivates cortisol to cortisone. HSD11Bs have been shown to be expressed in the ovary of various species. However, little is known about the expression and activity of HSD11Bs in the bovine cumulus-oocyte complex (COC). In the present study, we investigated the expression and activities of HSD11Bs in in vitro-matured (IVM) bovine COCs. Bovine COCs were matured in M199 supplemented with or without FSH and FCS. The expression of HSD11B1 and HSD11B2 was measured by using quantitative RT-PCR in denuded oocytes (DO) and cumulus cells (CC). Reductive and oxidative activities of HSD11Bs were determined by radiometric conversion assay using labeled cortisol, cortisone or dexamethasone in intact COCs, DO or CC in the presence or absence of 11-keto-progesterone (11kP), a selective inhibitor of HSD11B2. The presence of HSD11Bs in the oocyte was examined by immunofluorescence microscopy. Oocytes exclusively expressed HSD11B2 and its expression and activity were largely unchanged during IVM. CC, on the other hand, exclusively expressed HSD11B1 and its expression and activity were upregulated as IVM progressed. As a result, the net glucocorticoid metabolism shifted from inactivation to activation towards the end of IVM. These results indicate that the bovine COC is capable of modulating local glucocorticoid concentration and, by doing so, may create an environment that is favorable to ovulating oocyte for maturation, fertilization and subsequent development. PMID:26519454

  7. Safety of brilliant cresyl blue staining protocols on human granulosa and cumulus cells.

    PubMed

    Alcoba, Diego Duarte; Conzatti, Maiara; Ferreira, Gustavo Dias; Pimentel, Anita Mylius; Kussler, Ana Paula; Capp, Edison; von Eye Corleta, Helena; Brum, Ilma Simoni

    2016-02-01

    The selection of human immature oocytes destined for in vitro maturation (IVM) is performed according to their cumulus-oocyte complex (COC) morphology. In animal models, oocyte pre-selection with brilliant cresyl blue (BCB) staining improves fertilization and blastocyst rates and even increases the number of calves born. As the granulosa cells and cumulus cells (GCs and CCs) have a close relationship with the oocyte and are available in in vitro fertilization (IVF) programs, applying BCB staining to these cells may help to elucidate whether BCB shows toxicity to human oocytes and to determine the safest protocol for this dye. GCs and CCs were isolated from 24 patients who underwent controlled ovarian stimulation. After 48 h, cells were exposed to: Dulbecco's Modified Eagle Medium (DMEM) with or without phenol red, DPBS and mDPBS for 60 min; 13, 20 and 26 μM BCB for 60 min; and 60, 90 or 120 min to 13 μM BCB. Cellular viability was tested using 3-(4,5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) and trypan blue assays. The 20 and 26 μM BCB exposures resulted in lower cell viability, similar to when cells were exposed to BCB for 90 or 120 min. GCs and CCs viabilities were equal among control group and 13 μM BCB group after 60 min. BCB staining was not toxic to GCs and CCs when the regime of 13 μM BCB for 60 min was used. Due to the close molecular/biochemical relationship between these cells and the gamete, we propose that it is unlikely that the use of BCB could interfere with the viability/health of human oocytes. PMID:25921213

  8. Observational estimates of detrainment and entrainment in non-precipitating shallow cumulus

    NASA Astrophysics Data System (ADS)

    Norgren, M. S.; Small, J. D.; Jonsson, H. H.; Chuang, P. Y.

    2016-01-01

    Vertical transport associated with cumulus clouds is important to the redistribution of gases, particles, and energy, with subsequent consequences for many aspects of the climate system. Previous studies have suggested that detrainment from clouds can be comparable to the updraft mass flux, and thus represents an important contribution to vertical transport. In this study, we describe a new method to deduce the amounts of gross detrainment and entrainment experienced by non-precipitating cumulus clouds using aircraft observations. The method utilizes equations for three conserved variables: cloud mass, total water, and moist static energy. Optimizing these three equations leads to estimates of the mass fractions of adiabatic mixed-layer air, entrained air and detrained air that the sampled cloud has experienced. The method is applied to six flights of the CIRPAS Twin Otter during the Gulf of Mexico Atmospheric Composition and Climate Study (GoMACCS) which took place in the Houston, Texas region during the summer of 2006 during which 176 small, non-precipitating cumuli were sampled. Using our novel method, we find that, on average, these clouds were comprised of 30 to 70 % mixed-layer air, with entrained air comprising most of the remainder. The mass fraction of detrained air was usually very small, less than 2 %, although values larger than 10 % were found in 15 % of clouds. Entrained and detrained air mass fractions both increased with altitude, consistent with some previous observational studies. The largest detrainment events were almost all associated with air that was at their level of neutral buoyancy, which has been hypothesized in previous modeling studies. This new method could be readily used with data from other previous aircraft campaigns to expand our understanding of detrainment for a variety of cloud systems.

  9. The Impact of British Airways Wind Observations on the Goddard Earth Observing System Analyses and Forecasts

    NASA Technical Reports Server (NTRS)

    Rukhovets, Leonid; Sienkiewicz, M.; Tenenbaum, J.; Kondratyeva, Y.; Owens, T.; Oztunali, M.; Atlas, Robert (Technical Monitor)

    2001-01-01

    British Airways flight data recorders can provide valuable meteorological information, but they are not available in real-time on the Global Telecommunication System. Information from the flight recorders was used in the Global Aircraft Data Set (GADS) experiment as independent observations to estimate errors in wind analyses produced by major operational centers. The GADS impact on the Goddard Earth Observing System Data Assimilation System (GEOS DAS) analyses was investigated using GEOS-1 DAS version. Recently, a new Data Assimilation System (fvDAS) has been developed at the Data Assimilation Office, NASA Goddard. Using fvDAS , the, GADS impact on analyses and forecasts was investigated. It was shown the GADS data intensify wind speed analyses of jet streams for some cases. Five-day forecast anomaly correlations and root mean squares were calculated for 300, 500 hPa and SLP for six different areas: Northern and Southern Hemispheres, North America, Europe, Asia, USA These scores were obtained as averages over 21 forecasts from January 1998. Comparisons with scores for control experiments without GADS showed a positive impact of the GADS data on forecasts beyond 2-3 days for all levels at the most areas.

  10. Preliminary assessment of energy conservation opportunities at the NASA Goddard Space Flight Center, Greenbelt, Maryland

    SciTech Connect

    Hoffman, L.; Parker, G.B.

    1993-07-01

    The National Aeronautics and Space Administration is encouraging energy efficiency in its buildings and facilities as part of an overall strategy to meet the requirements of the Executive Order on Energy Efficiency and the Comprehensive Energy Policy Act of 1992. NASA requested technical assistance from the Pacific Northwest Laboratory to conduct a site visit, examine selected buildings and facilities, and suggest appropriate and economically acceptable energy efficiency measures and future actions at NASA`s Goddard Space Flight Center. PNL was also tasked to investigate the current and future demand-side management (DSM) programs offered by the servicing electric utility that would be applicable for the site. The information for this assessment was collected during site visits to the Goddard Space Flight Center during September and October 1992. The assessment addresses energy supply and cost, estimated energy distribution and use, and cost-effective options to reduce energy consumption at the center. Applicable utility DSM programs are also identified. A recommended strategy is identified to undertake a more comprehensive long-term energy reduction program at the site. A model approach is also given for the site to develop a partnership with the serving electric utility to implement a ``custom`` site-wide DSM program incorporating the several incentives offered by the utility to governmental agencies.

  11. Goddard Robotic Telescope - Optical Follow-up of GRBs and Coordinated Observations of AGNs

    NASA Technical Reports Server (NTRS)

    Sakamoto, T.; Wallace, C. A.; Donato, D.; Gehrels, N.; Okajima, T.; Ukwatta, T. N.

    2010-01-01

    Since it is not possible to predict when a Gamma-Ray Burst (GRB) will occur or when Active Galactic Nucleus (AGN) flaring activity starts, follow-up/monitoring ground telescopes must be located as uniformly as possible all over the world in order to collect data simultaneously with Fermi and Swift detections. However, there is a distinct gap in follow-up coverage of telescopes in the eastern U.S. region based on the operations of Swift. Motivated by this fact, we have constructed a 14" fully automated optical robotic telescope, Goddard Robotic Telescope (GRT), at the Goddard Geophysical and Astronomical Observatory. The aims of our robotic telescope are 1) to follow-up Swift/Fermi GRBs and 2) to perform the coordinated optical observations of Fermi Large Area Telescope (LAT) AGN. Our telescope system consists of off-the-shelf hardware. With the focal reducer, we are able to match the field of view of Swift narrow instruments (20' x 20'). We started scientific observations in mid-November 2008 and GRT has been fully remotely operated since August 2009. The 3(sigma) upper limit in a 30-second exposure in the R filter is approx.15.4 mag; however, we can reach to approx.18 mag in a 600-second exposures. Due to the weather condition at the telescope site. our observing efficiency is 30-40%, on average.

  12. The Goddard Integral Field Spectrograph at Apache Point Observatory: Current Status and Progress Towards Photon Counting

    NASA Astrophysics Data System (ADS)

    McElwain, Michael W.; Grady, Carol A.; Bally, John; Brinkmann, Jonathan V.; Bubeck, James; Gong, Qian; Hilton, George M.; Ketzeback, William F.; Lindler, Don; Llop Sayson, Jorge; Malatesta, Michael A.; Norton, Timothy; Rauscher, Bernard J.; Rothe, Johannes; Straka, Lorrie; Wilkins, Ashlee N.; Wisniewski, John P.; Woodgate, Bruce E.; York, Donald G.

    2015-01-01

    We present the current status and progress towards photon counting with the Goddard Integral Field Spectrograph (GIFS), a new instrument at the Apache Point Observatory's ARC 3.5m telescope. GIFS is a visible light imager and integral field spectrograph operating from 400-1000 nm over a 2.8' x 2.8' and 14' x 14' field of view, respectively. As an IFS, GIFS obtains over 1000 spectra simultaneously and its data reduction pipeline reconstructs them into an image cube that has 32 x 32 spatial elements and more than 200 spectral channels. The IFS mode can be applied to a wide variety of science programs including exoplanet transit spectroscopy, protostellar jets, the galactic interstellar medium probed by background quasars, Lyman-alpha emission line objects, and spectral imaging of galactic winds. An electron-multiplying CCD (EMCCD) detector enables photon counting in the high spectral resolution mode to be demonstrated at the ARC 3.5m in early 2015. The EMCCD work builds upon successful operational and characterization tests that have been conducted in the IFS laboratory at NASA Goddard. GIFS sets out to demonstrate an IFS photon-counting capability on-sky in preparation for future exoplanet direct imaging missions such as the AFTA-Coronagraph, Exo-C, and ATLAST mission concepts. This work is supported by the NASA APRA program under RTOP 10-APRA10-0103.

  13. Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

    PubMed Central

    Potter, Brittney M. J.; Xie, Lisa H.; Vuong, Chau; Zhang, Jing; Zhang, Ping; Duan, Dehui; Luong, Thu-Lan T.; Bandara Herath, H. M. T.; Dhammika Nanayakkara, N. P.; Tekwani, Babu L.; Walker, Larry A.; Nolan, Christina K.; Sciotti, Richard J.; Zottig, Victor E.; Smith, Philip L.; Paris, Robert M.; Read, Lisa T.; Li, Qigui; Pybus, Brandon S.; Sousa, Jason C.; Reichard, Gregory A.

    2015-01-01

    Primaquine (PQ) metabolism by the cytochrome P450 (CYP) 2D family of enzymes is required for antimalarial activity in both humans (2D6) and mice (2D). Human CYP 2D6 is highly polymorphic, and decreased CYP 2D6 enzyme activity has been linked to decreased PQ antimalarial activity. Despite the importance of CYP 2D metabolism in PQ efficacy, the exact role that these enzymes play in PQ metabolism and pharmacokinetics has not been extensively studied in vivo. In this study, a series of PQ pharmacokinetic experiments were conducted in mice with differential CYP 2D metabolism characteristics, including wild-type (WT), CYP 2D knockout (KO), and humanized CYP 2D6 (KO/knock-in [KO/KI]) mice. Plasma and liver pharmacokinetic profiles from a single PQ dose (20 mg/kg of body weight) differed significantly among the strains for PQ and carboxy-PQ. Additionally, due to the suspected role of phenolic metabolites in PQ efficacy, these were probed using reference standards. Levels of phenolic metabolites were highest in mice capable of metabolizing CYP 2D6 substrates (WT and KO/KI 2D6 mice). PQ phenolic metabolites were present in different quantities in the two strains, illustrating species-specific differences in PQ metabolism between the human and mouse enzymes. Taking the data together, this report furthers understanding of PQ pharmacokinetics in the context of differential CYP 2D metabolism and has important implications for PQ administration in humans with different levels of CYP 2D6 enzyme activity. PMID:25645856

  14. 2D to 3D to 2D Dimensionality Crossovers in Thin BSCCO Films

    NASA Astrophysics Data System (ADS)

    Williams, Gary A.

    2003-03-01

    With increasing temperature the superfluid fraction in very thin BSCCO films undergoes a series of dimensionality crossovers. At low temperatures the strong anisotropy causes the thermal excitations to be 2D pancake-antipancake pairs in uncoupled layers. At higher temperatures where the c-axis correlation length becomes larger than a layer there is a crossover to 3D vortex loops. These are initially elliptical, but as the 3D Tc is approached they become more circular as the anisotropy scales away, as modeled by Shenoy and Chattopadhyay [1]. Close to Tc when the correlation length becomes comparable to the film thickness there is a further crossover to a 2D Kosterlitz-Thouless transition, with a drop of the superfluid fraction to zero at T_KT which can be of the order of 1 K below T_c. Good agreement with this model is found for experiments on thin BSCCO 2212 films [2]. 1. S. R. Shenoy and B. Chattopadhyay, Phys. Rev. B 51, 9129 (1995). 2. K. Osborn et al., cond-mat/0204417.

  15. Mechanical characterization of 2D, 2D stitched, and 3D braided/RTM materials

    NASA Technical Reports Server (NTRS)

    Deaton, Jerry W.; Kullerd, Susan M.; Portanova, Marc A.

    1993-01-01

    Braided composite materials have potential for application in aircraft structures. Fuselage frames, floor beams, wing spars, and stiffeners are examples where braided composites could find application if cost effective processing and damage tolerance requirements are met. Another important consideration for braided composites relates to their mechanical properties and how they compare to the properties of composites produced by other textile composite processes being proposed for these applications. Unfortunately, mechanical property data for braided composites do not appear extensively in the literature. Data are presented in this paper on the mechanical characterization of 2D triaxial braid, 2D triaxial braid plus stitching, and 3D (through-the-thickness) braid composite materials. The braided preforms all had the same graphite tow size and the same nominal braid architectures, (+/- 30 deg/0 deg), and were resin transfer molded (RTM) using the same mold for each of two different resin systems. Static data are presented for notched and unnotched tension, notched and unnotched compression, and compression after impact strengths at room temperature. In addition, some static results, after environmental conditioning, are included. Baseline tension and compression fatigue results are also presented, but only for the 3D braided composite material with one of the resin systems.

  16. Differential Cytochrome P450 2D Metabolism Alters Tafenoquine Pharmacokinetics

    PubMed Central

    Vuong, Chau; Xie, Lisa H.; Potter, Brittney M. J.; Zhang, Jing; Zhang, Ping; Duan, Dehui; Nolan, Christina K.; Sciotti, Richard J.; Zottig, Victor E.; Nanayakkara, N. P. Dhammika; Tekwani, Babu L.; Walker, Larry A.; Smith, Philip L.; Paris, Robert M.; Read, Lisa T.; Li, Qigui; Pybus, Brandon S.; Sousa, Jason C.; Reichard, Gregory A.; Smith, Bryan

    2015-01-01

    Cytochrome P450 (CYP) 2D metabolism is required for the liver-stage antimalarial efficacy of the 8-aminoquinoline molecule tafenoquine in mice. This could be problematic for Plasmodium vivax radical cure, as the human CYP 2D ortholog (2D6) is highly polymorphic. Diminished CYP 2D6 enzyme activity, as in the poor-metabolizer phenotype, could compromise radical curative efficacy in humans. Despite the importance of CYP 2D metabolism for tafenoquine liver-stage efficacy, the exact role that CYP 2D metabolism plays in the metabolism and pharmacokinetics of tafenoquine and other 8-aminoquinoline molecules has not been extensively studied. In this study, a series of tafenoquine pharmacokinetic experiments were conducted in mice with different CYP 2D metabolism statuses, including wild-type (WT) (reflecting extensive metabolizers for CYP 2D6 substrates) and CYPmouse 2D knockout (KO) (reflecting poor metabolizers for CYP 2D6 substrates) mice. Plasma and liver pharmacokinetic profiles from a single 20-mg/kg of body weight dose of tafenoquine differed between the strains; however, the differences were less striking than previous results obtained for primaquine in the same model. Additionally, the presence of a 5,6-ortho-quinone tafenoquine metabolite was examined in both mouse strains. The 5,6-ortho-quinone species of tafenoquine was observed, and concentrations of the metabolite were highest in the WT extensive-metabolizer phenotype. Altogether, this study indicates that CYP 2D metabolism in mice affects tafenoquine pharmacokinetics and could have implications for human tafenoquine pharmacokinetics in polymorphic CYP 2D6 human populations. PMID:25870069

  17. A Geometric Boolean Library for 2D Objects

    2006-01-05

    The 2D Boolean Library is a collection of C++ classes -- which primarily represent 2D geometric data and relationships, and routines -- which contain algorithms for 2D geometric Boolean operations and utility functions. Classes are provided for 2D points, lines, arcs, edgeuses, loops, surfaces and mask sets. Routines are provided that incorporate the Boolean operations Union(OR), XOR, Intersection and Difference. Various analytical geometry routines and routines for importing and exporting the data in various filemore » formats, are also provided in the library.« less

  18. A Geometric Boolean Library for 2D Objects

    SciTech Connect

    McBride, Corey L.; Yarberry, Victor; Jorgensen, Craig

    2006-01-05

    The 2D Boolean Library is a collection of C++ classes -- which primarily represent 2D geometric data and relationships, and routines -- which contain algorithms for 2D geometric Boolean operations and utility functions. Classes are provided for 2D points, lines, arcs, edgeuses, loops, surfaces and mask sets. Routines are provided that incorporate the Boolean operations Union(OR), XOR, Intersection and Difference. Various analytical geometry routines and routines for importing and exporting the data in various file formats, are also provided in the library.

  19. AnisWave2D: User's Guide to the 2d Anisotropic Finite-DifferenceCode

    SciTech Connect

    Toomey, Aoife

    2005-01-06

    This document describes a parallel finite-difference code for modeling wave propagation in 2D, fully anisotropic materials. The code utilizes a mesh refinement scheme to improve computational efficiency. Mesh refinement allows the grid spacing to be tailored to the velocity model, so that fine grid spacing can be used in low velocity zones where the seismic wavelength is short, and coarse grid spacing can be used in zones with higher material velocities. Over-sampling of the seismic wavefield in high velocity zones is therefore avoided. The code has been implemented to run in parallel over multiple processors and allows large-scale models and models with large velocity contrasts to be simulated with ease.

  20. Klassifikation von Standardebenen in der 2D-Echokardiographie mittels 2D-3D-Bildregistrierung

    NASA Astrophysics Data System (ADS)

    Bergmeir, Christoph; Subramanian, Navneeth

    Zum Zweck der Entwicklung eines Systems, das einen unerfahrenen Anwender von Ultraschall (US) zur Aufnahme relevanter anatomischer Strukturen leitet, untersuchen wir die Machbarkeit von 2D-US zu 3D-CT Registrierung. Wir verwenden US-Aufnahmen von Standardebenen des Herzens, welche zu einem 3D-CT-Modell registriert werden. Unser Algorithmus unterzieht sowohl die US-Bilder als auch den CT-Datensatz Vorverarbeitungsschritten, welche die Daten durch Segmentierung auf wesentliche Informationen in Form von Labein für Muskel und Blut reduzieren. Anschließend werden diese Label zur Registrierung mittels der Match-Cardinality-Metrik genutzt. Durch mehrmaliges Registrieren mit verschiedenen Initialisierungen ermitteln wir die im US-Bild sichtbare Standardebene. Wir evaluierten die Methode auf sieben US-Bildern von Standardebenen. Fünf davon wurden korrekt zugeordnet.

  1. Supporting Research at NASA's Goddard Space Flight Center Through Focused Education and Outreach Programs

    NASA Astrophysics Data System (ADS)

    Ireton, F.; Closs, J.

    2003-12-01

    NASA research scientists work closely with Science Systems and Applications, Inc. (SSAI) personnel at Goddard Space Flight Center (GSFC) on a large variety of education and public outreach (E/PO) initiatives. This work includes assistance in conceptualizing E/PO plans, then carrying through in the development of materials, publication, cataloging, warehousing, and product distribution. For instance, outreach efforts on the Terra, Aqua, and Aura-still in development-EOS missions, as well as planetary and visualization programs, have been coordinated by SSAI employees. E/PO support includes convening and taking part in sessions at professional meetings and workshops. Also included is the coordination of exhibits at professional meetings such as the AGU, AAAS, AMS and educational meetings such as the National Science Teachers Association. Other E/PO efforts include the development and staffing of booths; arranges for booth space and furnishings; shipping of exhibition materials and products; assembling, stocking, and disassembling of booths. E/PO personnel work with organizations external to NASA such as the Smithsonian museum, Library of Congress, U.S. Geological Survey, and associations or societies such as the AGU, American Chemical Society, and National Science Teachers Association to develop products and programs that enhance NASA mission E/PO efforts or to provide NASA information for use in their programs. At GSFC, E/PO personnel coordinate the efforts of the education and public outreach sub-committees in support of the Space and Earth Sciences Data Analysis (SESDA) contract within the GSFC Earth Sciences Directorate. The committee acts as a forum for improving communication and coordination among related Earth science education projects, and strives to unify the representation of these programs among the science and education communities. To facilitate these goals a Goddard Earth Sciences Directorate Education and Outreach Portal has been developed to provide

  2. Functional characterization of CYP2D6 enhancer polymorphisms

    PubMed Central

    Wang, Danxin; Papp, Audrey C.; Sun, Xiaochun

    2015-01-01

    CYP2D6 metabolizes nearly 25% of clinically used drugs. Genetic polymorphisms cause large inter-individual variability in CYP2D6 enzyme activity and are currently used as biomarker to predict CYP2D6 metabolizer phenotype. Previously, we had identified a region 115 kb downstream of CYP2D6 as enhancer for CYP2D6, containing two completely linked single nucleotide polymorphisms (SNPs), rs133333 and rs5758550, associated with enhanced transcription. However, the enhancer effect on CYP2D6 expression, and the causative variant, remained to be ascertained. To characterize the CYP2D6 enhancer element, we applied chromatin conformation capture combined with the next-generation sequencing (4C assays) and chromatin immunoprecipitation with P300 antibody, in HepG2 and human primary culture hepatocytes. The results confirmed the role of the previously identified enhancer region in CYP2D6 expression, expanding the number of candidate variants to three highly linked SNPs (rs133333, rs5758550 and rs4822082). Among these, only rs5758550 demonstrated regulating enhancer activity in a reporter gene assay. Use of clustered regularly interspaced short palindromic repeats mediated genome editing in HepG2 cells targeting suspected enhancer regions decreased CYP2D6 mRNA expression by 70%, only upon deletion of the rs5758550 region. These results demonstrate robust effects of both the enhancer element and SNP rs5758550 on CYP2D6 expression, supporting consideration of rs5758550 for CYP2D6 genotyping panels to yield more accurate phenotype prediction. PMID:25381333

  3. An Incompressible 2D Didactic Model with Singularity and Explicit Solutions of the 2D Boussinesq Equations

    NASA Astrophysics Data System (ADS)

    Chae, Dongho; Constantin, Peter; Wu, Jiahong

    2014-09-01

    We give an example of a well posed, finite energy, 2D incompressible active scalar equation with the same scaling as the surface quasi-geostrophic equation and prove that it can produce finite time singularities. In spite of its simplicity, this seems to be the first such example. Further, we construct explicit solutions of the 2D Boussinesq equations whose gradients grow exponentially in time for all time. In addition, we introduce a variant of the 2D Boussinesq equations which is perhaps a more faithful companion of the 3D axisymmetric Euler equations than the usual 2D Boussinesq equations.

  4. The Integrated Mission Design Center (IMDC) at NASA Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Karpati, Gabriel; Martin, John; Steiner, Mark; Reinhardt, K.

    2002-01-01

    NASA Goddard has used its Integrated Mission Design Center (IMDC) to perform more than 150 mission concept studies. The IMDC performs rapid development of high-level, end-to-end mission concepts, typically in just 4 days. The approach to the studies varies, depending on whether the proposed mission is near-future using existing technology, mid-future using new technology being actively developed, or far-future using technology which may not yet be clearly defined. The emphasis and level of detail developed during any particular study depends on which timeframe (near-, mid-, or far-future) is involved and the specific needs of the study client. The most effective mission studies are those where mission capabilities required and emerging technology developments can synergistically work together; thus both enhancing mission capabilities and providing impetus for ongoing technology development.

  5. Large-Scale Hollow Retroreflectors for Lunar Laser Ranging at Goddard Space Flight Center

    NASA Astrophysics Data System (ADS)

    Preston, Alix M.

    2012-05-01

    Laser ranging to the retroreflector arrays placed on the lunar surface by the Apollo astronauts and the Soviet Luna missions have dramatically increased our understanding of gravitational physics along with Earth and Moon geophysics, geodesy, and dynamics. Although the precision of the range measurements has historically been limited by the ground station capabilities, advances in the APOLLO instrument at the Apache Point facility in New Mexico is beginning to be limited by errors associated with the lunar arrays. We report here on efforts at Goddard Space Flight Center to develop the next generation of lunar retroreflectors. We will describe a new facility that is being used to design, assemble, and test large-scale hollow retroreflectors. We will also describe results from investigations into various bonding techniques used to assemble the open corner cubes and mirror coatings that have dust mitigation properties.

  6. Two color satellite laser ranging upgrades at Goddard's 1.2m telescope facility

    NASA Technical Reports Server (NTRS)

    Zagwodzki, Thomas W.; Mcgarry, Jan F.; Degnan, John J.; Varghese, Thomas K.

    1993-01-01

    The ranging laboratory at Goddard's 1.2 m telescope tracking facility has recently been upgraded to include a single photoelectron sensitive Hamamatsu streak camera-based range receiver which uses doubled and tripled Nd:YAG frequencies for satellite laser ranging. Other ranging system upgrades include a new continuum laser, which will deliver up to 30 millijoules (mJ) at both 532 and 355 nm at a pulsewidth of 30 picoseconds (FWHM), and replacement of both ranging and tracking computers with COMPAQ 386 based systems. Preliminary results using a photomultiplier-tube based receiver and waveform digitizer indicate agreement within the accuracy of the measurement with the theoretical Marini and Murray model for atmospheric refraction. Two color streak camera measurements are used to further analyze the accuracy of these and other atmospheric refraction models.

  7. Documentation and Validation of the Goddard Earth Observing System (GEOS) Data Assimilation System, Version 4

    NASA Technical Reports Server (NTRS)

    Suarez, Max J. (Editor); daSilva, Arlindo; Dee, Dick; Bloom, Stephen; Bosilovich, Michael; Pawson, Steven; Schubert, Siegfried; Wu, Man-Li; Sienkiewicz, Meta; Stajner, Ivanka

    2005-01-01

    This document describes the structure and validation of a frozen version of the Goddard Earth Observing System Data Assimilation System (GEOS DAS): GEOS-4.0.3. Significant features of GEOS-4 include: version 3 of the Community Climate Model (CCM3) with the addition of a finite volume dynamical core; version two of the Community Land Model (CLM2); the Physical-space Statistical Analysis System (PSAS); and an interactive retrieval system (iRET) for assimilating TOVS radiance data. Upon completion of the GEOS-4 validation in December 2003, GEOS-4 became operational on 15 January 2004. Products from GEOS-4 have been used in supporting field campaigns and for reprocessing several years of data for CERES.

  8. Atomic Physics with the Goddard High Resolution Spectrograph on the Hubble Space Telescope

    NASA Astrophysics Data System (ADS)

    Zsargo, J.; Federman, S. R.; Cardelli, Jason A.

    1997-08-01

    High quality spectra of interstellar absorption from C I toward beta1 Sco, rho Oph A, and chi Oph were obtained with the Goddard High Resolution Spectrograph on HST. Many weak lines were detected within the observed wavelength intervals: 1150-1200 A for beta1 Sco and 1250-1290 A for rho Oph A and chi Oph. Curve-of-growth analyses were performed in order to extract accurate column densities and Doppler parameters from lines with precise laboratory-based f-values. These column densities and b-values were used to obtain a self-consistent set of f-values for all the observed C I lines. A particularly important constraint was the need to reproduce data for more than one line of sight. For about 50% of the lines, the derived f-values differ appreciably from the values quoted by Morton.

  9. Goddard's new 39,000 cubic foot low frequency acoustic test facility

    NASA Technical Reports Server (NTRS)

    Kirchman, E.

    1980-01-01

    The Goddard Space Flight Center's 39,000 cu ft acoustic chamber for testing both shuttle-launched payloads and payloads launched by expendable vehicles is described. Chamber requirements and design problems are reviewed, and safety systems are discussed. It is shown that: (1) the maximum overall sound-pressure level obtained with two 10-kW transducers is 150 dB; (2) at least seven modes between 25 and 40 Hz have been identified in the preliminary evaluation of the chamber; (3) two discernible dips, localized to individual doors, occur in the LF spectrum, at 30-33 and 42-44 Hz; and (4) the reverberation times measured for 60-dB decay range from 7 sec at 40 Hz to a maximum of 19 sec at 125 Hz, with an average of 13.4 sec at 1000 Hz.

  10. Version 2 Goddard Satellite-Based Surface Turbulent Fluxes (GSSTF2)

    NASA Technical Reports Server (NTRS)

    Chou, Shu-Hsien; Nelkin, Eric; Ardizzone, Joe; Atlas, Robert M.; Shie, Chung-Lin; Starr, David O'C. (Technical Monitor)

    2002-01-01

    Information on the turbulent fluxes of momentum, moisture, and heat at the air-sea interface is essential in improving model simulations of climate variations and in climate studies. We have derived a 13.5-year (July 1987-December 2000) dataset of daily surface turbulent fluxes over global oceans from the Special Sensor Mcrowave/Imager (SSM/I) radiance measurements. This dataset, version 2 Goddard Satellite-based Surface Turbulent Fluxes (GSSTF2), has a spatial resolution of 1 degree x 1 degree latitude-longitude and a temporal resolution of 1 day. Turbulent fluxes are derived from the SSM/I surface winds and surface air humidity, as well as the 2-m air and sea surface temperatures (SST) of the NCEP/NCAR reanalysis, using a bulk aerodynamic algorithm based on the surface layer similarity theory.

  11. Upgrades to Electronic Speckle Interferometer (ESPI) Operation and Data Analysis at NASA's Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Connelly, Joseph; Blake, Peter; Jones, Joycelyn

    2008-01-01

    The authors report operational upgrades and streamlined data analysis of a commissioned electronic speckle interferometer (ESPI) in a permanent in-house facility at NASA's Goddard Space Flight Center. Our ESPI was commercially purchased for use by the James Webb Space Telescope (JWST) development team. We have quantified and reduced systematic error sources, improved the software operability with a user-friendly graphic interface, developed an instrument simulator, streamlined data analysis for long-duration testing, and implemented a turn-key approach to speckle interferometry. We also summarize results from a test of the JWST support structure (previously published), and present new results from several pieces of test hardware at various environmental conditions.

  12. NASA/Goddard Space Flight Center's testbed for CCSDS compatible systems

    NASA Technical Reports Server (NTRS)

    Carper, Richard D.

    1993-01-01

    A testbed for flight and ground systems compatible with the Consultative Committee for Space Data Systems (CCSDS) Recommendations has been developed at NASA's Goddard Space Flight Center. The subsystems of an end-to-end CCSDS based data system are being developed. All return link CCSDS telemetry services (except Internet) and both versions of the CCSDS frame formats are being implemented. In key areas of uncertainty, multiple design approaches are being performed. In addition, key flight-qualifiable hardware components, such as Reed-Solomon encoders, are being developed to complement the testbed element development. The testbed and its capabilities are described. The method of dissemination of the testbed results are given, as are plans to make the testbed capabilities available to outside users. Plans for the development of standardized conformance and compatibility tests are provided.

  13. Astronomical applications of the new Goddard Si:Bi 16 x 16 array camera system

    NASA Technical Reports Server (NTRS)

    Lamb, G.; Gezari, D.; Shu, P.; Tresch-Fienberg, R.; Fazio, G.; Hoffmann, W.; Mccreight, C.

    1984-01-01

    An improved 4-18 micron array camera system has been developed at NASA Goddard Space Flight Center for astronomical protometry, using 16 x 16 Si:Bi (bismuth dope silicon) accumulation mode charge injection device (AMCID) with 256 active pixels. An astronomical observing program using this device has been carried out. The 16 x 16 device had sufficiently good sensitivity, uniformity and noise characteristics to be used for successful observations at the Steward Observatory Mt. Lemmon 60 and 61-inch telescopes in May 1983, and at the NASA Infrared Telescope Facility (IRTF) at Mauna Kea in August 1983. Initial results indicate that this detector has sensitivity and noise characteristics comparable to other devices from the same generation of Aerojet arrays.

  14. NASA/Goddard Space Flight Center's testbed for CCSDS compatible systems

    NASA Astrophysics Data System (ADS)

    Carper, Richard D.

    1993-03-01

    A testbed for flight and ground systems compatible with the Consultative Committee for Space Data Systems (CCSDS) Recommendations has been developed at NASA's Goddard Space Flight Center. The subsystems of an end-to-end CCSDS based data system are being developed. All return link CCSDS telemetry services (except Internet) and both versions of the CCSDS frame formats are being implemented. In key areas of uncertainty, multiple design approaches are being performed. In addition, key flight-qualifiable hardware components, such as Reed-Solomon encoders, are being developed to complement the testbed element development. The testbed and its capabilities are described. The method of dissemination of the testbed results are given, as are plans to make the testbed capabilities available to outside users. Plans for the development of standardized conformance and compatibility tests are provided.

  15. From Bonaventure to Goddard: How I Got to NASA and What I Am Doing There

    NASA Technical Reports Server (NTRS)

    Miller, Kevin H.

    2014-01-01

    The presentation, accompanied by slides when appropriate, will describe how a young physics major travelled from the classrooms of Saint Bonaventure, to the graduate research laboratories of the University of Florida in Gainesville, and finally to the government laboratories of NASA at the Goddard Space Flight Center just north of Washington, D.C. The main portion of the presentation concerns NASA missions of interest to the general public and supported in part by research work he does. Such, for example, is the current flagship mission of NASA, the James Webb Space Telescope that is destined to replace very soon the Hubble Space Telescope. In addition to these NASA telescope missions, a mission to an asteroid, coined the OSIRIS REX program, is in process and will be described.

  16. Large-Scale Hollow Retroreflectors for Lunar Laser Ranging at Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Preston, Alix

    2012-01-01

    Laser ranging to the retroreflector arrays placed on the lunar surface by the Apollo astronauts and the Soviet Luna missions have dramatically increased our understanding of gravitational physics along with Earth and Moon geophysics, geodesy, and dynamics. Although the precision of the range measurements has historically been limited by the ground station capabilities, advances in the APOLLO instrument at the Apache Point facility in New Mexico is beginning to be limited by errors associated with the lunar arrays. We report here on efforts at Goddard Space Flight Center to develop the next generation of lunar retroreflectors. We will describe a new facility that is being used to design, assemble, and test large-scale hollow retroreflectors. We will also describe results from investigations into various bonding techniques used to assemble the open comer cubes and mirror coatings that have dust mitigation properties.

  17. Hollow Retroreflectors for Lunar Laser Ranging at Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Preston, Alix M.; Merkowitz, Stephen M.

    2012-01-01

    Laser ranging to the retroreflector arrays placed on the lunar surface by the Apollo astronauts and the Soviet Luna missions have dramatically increased our understanding of gravitational physics along with Earth and Moon geophysics, geodesy, and dynamics. Although the precision of the range measurements has historically been limited by the ground station capabilities, advances in the APOLLO instrument at the Apache Point facility in New Mexico is beginning to be limited by errors associated with the lunar arrays. At Goddard Space Flight Center, we have developed a facility where we can design, build, and test next-generation hollow retroreflectors for Lunar Laser Ranging. Here we will describe this facility as well as report on the bonding techniques used to assemble the retroreflectors. Results from investigations into different high reflectivity mirror coatings, as well as dust mitigation coatings will also be presented.

  18. Fifth NASA Goddard Conference on Mass Storage Systems and Technologies. Volume 2

    NASA Technical Reports Server (NTRS)

    Kobler, Benjamin (Editor); Hariharan, P. C. (Editor)

    1996-01-01

    This document contains copies of those technical papers received in time for publication prior to the Fifth Goddard Conference on Mass Storage Systems and Technologies held September 17 - 19, 1996, at the University of Maryland, University Conference Center in College Park, Maryland. As one of an ongoing series, this conference continues to serve as a unique medium for the exchange of information on topics relating to the ingestion and management of substantial amounts of data and the attendant problems involved. This year's discussion topics include storage architecture, database management, data distribution, file system performance and modeling, and optical recording technology. There will also be a paper on Application Programming Interfaces (API) for a Physical Volume Repository (PVR) defined in Version 5 of the Institute of Electrical and Electronics Engineers (IEEE) Reference Model (RM). In addition, there are papers on specific archives and storage products.

  19. Fifth NASA Goddard Conference on Mass Storage Systems and Technologies.. Volume 1

    NASA Technical Reports Server (NTRS)

    Kobler, Benjamin (Editor); Hariharan, P. C. (Editor)

    1996-01-01

    This document contains copies of those technical papers received in time for publication prior to the Fifth Goddard Conference on Mass Storage Systems and Technologies. As one of an ongoing series, this conference continues to serve as a unique medium for the exchange of information on topics relating to the ingestion and management of substantial amounts of data and the attendant problems involved. This year's discussion topics include storage architecture, database management, data distribution, file system performance and modeling, and optical recording technology. There will also be a paper on Application Programming Interfaces (API) for a Physical Volume Repository (PVR) defined in Version 5 of the Institute of Electrical and Electronics Engineers (IEEE) Reference Model (RM). In addition, there are papers on specific archives and storage products.

  20. The Third NASA Goddard Conference on Mass Storage Systems and Technologies

    NASA Technical Reports Server (NTRS)

    Kobler, Benjamin (Editor); Hariharan, P. C. (Editor)

    1993-01-01

    This report contains copies of nearly all of the technical papers and viewgraphs presented at the Goddard Conference on Mass Storage Systems and Technologies held in October 1993. The conference served as an informational exchange forum for topics primarily relating to the ingestion and management of massive amounts of data and the attendant problems involved. Discussion topics include the necessary use of computers in the solution of today's infinitely complex problems, the need for greatly increased storage densities in both optical and magnetic recording media, currently popular storage media and magnetic media storage risk factors, data archiving standards including a talk on the current status of the IEEE Storage Systems Reference Model (RM). Additional topics addressed System performance, data storage system concepts, communications technologies, data distribution systems, data compression, and error detection and correction.

  1. Two color satellite laser ranging upgrades at Goddard's 1.2m telescope facility

    NASA Astrophysics Data System (ADS)

    Zagwodzki, Thomas W.; McGarry, Jan F.; Degnan, John J.; Varghese, Thomas K.

    1993-06-01

    The ranging laboratory at Goddard's 1.2 m telescope tracking facility has recently been upgraded to include a single photoelectron sensitive Hamamatsu streak camera-based range receiver which uses doubled and tripled Nd:YAG frequencies for satellite laser ranging. Other ranging system upgrades include a new continuum laser, which will deliver up to 30 millijoules (mJ) at both 532 and 355 nm at a pulsewidth of 30 picoseconds (FWHM), and replacement of both ranging and tracking computers with COMPAQ 386 based systems. Preliminary results using a photomultiplier-tube based receiver and waveform digitizer indicate agreement within the accuracy of the measurement with the theoretical Marini and Murray model for atmospheric refraction. Two color streak camera measurements are used to further analyze the accuracy of these and other atmospheric refraction models.

  2. Failure rate analysis of Goddard Space Flight Center spacecraft performance during orbital life

    NASA Technical Reports Server (NTRS)

    Norris, H. P.; Timmins, A. R.

    1976-01-01

    Space life performance data on 57 Goddard Space Flight Center spacecraft are analyzed from the standpoint of determining an appropriate reliability model and the associated reliability parameters. Data from published NASA reports, which cover the space performance of GSFC spacecraft launched in the 1960-1970 decade, form the basis of the analyses. The results of the analyses show that the time distribution of 449 malfunctions, of which 248 were classified as failures (not necessarily catastrophic), follow a reliability growth pattern that can be described with either the Duane model or a Weibull distribution. The advantages of both mathematical models are used in order to: identify space failure rates, observe chronological trends, and compare failure rates with those experienced during the prelaunch environmental tests of the flight model spacecraft.

  3. The 2003 Goddard Rocket Replica Project: A Reconstruction of the World's First Functional Liquid Rocket System

    NASA Technical Reports Server (NTRS)

    Farr, R. A.; Elam, S. K.; Hicks, G. D.; Sanders, T. M.; London, J. R.; Mayne, A. W.; Christensen, D. L.

    2003-01-01

    As a part of NASA s 2003 Centennial of Flight celebration, engineers and technicians at Marshall Space Flight Center (MSFC), Huntsville, Alabama, in cooperation with the Alabama-Mississippi AIAA Section, have reconstructed historically accurate, functional replicas of Dr. Robert H. Goddard s 1926 first liquid- fuel rocket. The purposes of this project were to clearly understand, recreate, and document the mechanisms and workings of the 1926 rocket for exhibit and educational use, creating a vital resource for researchers studying the evolution of liquid rocketry for years to come. The MSFC team s reverse engineering activity has created detailed engineering-quality drawings and specifications describing the original rocket and how it was built, tested, and operated. Static hot-fire tests, as well as flight demonstrations, have further defined and quantified the actual performance and engineering actual performance and engineering challenges of this major segment in early aerospace history.

  4. Profiling Tropospheric Winds with the Goddard Lidar Observatory for Winds (GLOW)

    NASA Technical Reports Server (NTRS)

    Gentry, Bruce M.; Chen, Huailin; Starr, David OC. (Technical Monitor)

    2002-01-01

    The Goddard Lidar Observatory for Winds (GLOW) is a mobile direct detection Doppler lidar system designed to measure wind profiles from the surface into the lower stratosphere. Recently, the GLOW lidar has participated in several field deployments measuring tropospheric winds in a variety of conditions including both daytime and night operation. More than 50 hours of line-of-sight wind profit data were obtained in September, 2000 during a three week intercomparison experiment at the Ground Winds facility in North Glen, NH. Typical clear air lidar wind profiles extended to altitudes of 20 km with a 1 km vertical resolution and 1 minute averaging. An additional 40 hours of lidar profiles of wind speed and direction were obtained during HARGLO-2, an intercomparison experiment held at Wallops Flight Facility, VA in November, 2001. A description of the mobile system is presented along with the examples of validated lidar wind profiles obtained during these experiments.

  5. Photonic Component Qualification and Implementation Activities at NASA Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Ott, Melanie N.; Jin, Xiaodan Linda; Chuska, Richard F.; LaRocca, Frank V.; MacMurphy, Shawn L.; Matuszeski, Adam J.; Zellar, Ronald S.; Friedberg, Patricia R.; Malenab, Mary C.

    2006-01-01

    The photonics group in Code 562 at NASA Goddard Space Flight Center supports a variety of space flight programs at NASA including the: International Space Station (ISS), Shuttle Return to Flight Mission, Lunar Reconnaissance Orbiter (LRO), Express Logistics Carrier, and the NASA Electronic Parts and Packaging Program (NEPP). Through research, development, and testing of the photonic systems to support these missions much information has been gathered on practical implementations for space environments. Presented here are the highlights and lessons learned as a result of striving to satisfy the project requirements for high performance and reliable commercial optical fiber components for space flight systems. The approach of how to qualify optical fiber components for harsh environmental conditions, the physics of failure and development lessons learned will be discussed.

  6. Global climate changes as forecast by Goddard Institute for Space Studies three-dimensional model

    NASA Technical Reports Server (NTRS)

    Hansen, J.; Fung, I.; Lacis, A.; Rind, D.; Lebedeff, S.; Ruedy, R.; Russell, G.

    1988-01-01

    The global climate effects of time-dependent atmospheric trace gas and aerosol variations are simulated by NASA-Goddard's three-dimensional climate model II, which possesses 8 x 10-deg horizontal resolution, for the cases of a 100-year control run and three different atmospheric composition scenarios in which trace gas growth is respectively a continuation of current exponential trends, a reduced linear growth, and a rapid curtailment of emissions due to which net climate forcing no longer increases after the year 2000. The experiments begin in 1958, run to the present, and encompass measured or estimated changes in CO2, CH4, N2O, chlorofluorocarbons, and stratospheric aerosols. It is shown that the greenhouse warming effect may be clearly identifiable in the 1990s.

  7. Upgrade of the Goddard Space Flight Center's Mass Properties Measuring Facility

    NASA Technical Reports Server (NTRS)

    Ross, Brian P.; McLeod, Christopher

    2004-01-01

    Goddard Space Flight Center has a Mass Properties Measuring Facility (MPMF), which is used to measure weight, center of gravity, moment of inertia, and product of inertia of satellites and space flight hardware. The system was originally purchased more than 30 years ago. While the MPMF was still in good mechanical condition, the measurement and control subsystem had begun to experience more frequent component failures. Many of the outdated, discrete components in the system are no longer available for replacement. A decision was made to upgrade the measurement and control subsystem of the MPMF to improve its reliability and reduce the chance of component failures leading to extended facility outages. This paper will describe details of the upgraded subsystems and summarize the new performance capabilities of the system.

  8. The 1994 research and technology report at the Goddard Space Flight Center

    NASA Technical Reports Server (NTRS)

    Soffen, Gerald (Editor); Halem, Milton (Editor); Green, James (Editor); Frost, Kenneth (Editor); Maran, Stephen (Editor); Boyle, Charles (Editor); Truszlowski, Walter (Editor); Sullivan, Walter (Editor); Ottenstein, Howard (Editor)

    1994-01-01

    The breadth of subject material in this 1994 edition of the Research and Technology Report illustrates the broad scope of activities at the Goddard Space Flight Center. The numerous entries dealing with data processing and visualization show the strong emphasis on data and its interpretation. Reports are presented in the following sections: data processing and visualization; space sciences - high energy astronomy, solar system, and new techniques; earth system science - atmospheres, oceans and ice, solid earth, and soils and vegetation; networks, planning, and information systems - mission scheduling and operations, spacecraft operation and status, software engineering, and infrastructure support; engineering and materials - spacecraft subsystems, launch vehicles, thermal control, new mechanisms, and testing and evaluation; and flight projects.

  9. Efficient Visible Quasi-2D Perovskite Light-Emitting Diodes.

    PubMed

    Byun, Jinwoo; Cho, Himchan; Wolf, Christoph; Jang, Mi; Sadhanala, Aditya; Friend, Richard H; Yang, Hoichang; Lee, Tae-Woo

    2016-09-01

    Efficient quasi-2D-structure perovskite light-emitting diodes (4.90 cd A(-1) ) are demonstrated by mixing a 3D-structured perovskite material (methyl ammonium lead bromide) and a 2D-structured perovskite material (phenylethyl ammonium lead bromide), which can be ascribed to better film uniformity, enhanced exciton confinement, and reduced trap density. PMID:27334788

  10. Integrating Mobile Multimedia into Textbooks: 2D Barcodes

    ERIC Educational Resources Information Center

    Uluyol, Celebi; Agca, R. Kagan

    2012-01-01

    The major goal of this study was to empirically compare text-plus-mobile phone learning using an integrated 2D barcode tag in a printed text with three other conditions described in multimedia learning theory. The method examined in the study involved modifications of the instructional material such that: a 2D barcode was used near the text, the…

  11. Van der Waals stacked 2D layered materials for optoelectronics

    NASA Astrophysics Data System (ADS)

    Zhang, Wenjing; Wang, Qixing; Chen, Yu; Wang, Zhuo; Wee, Andrew T. S.

    2016-06-01

    The band gaps of many atomically thin 2D layered materials such as graphene, black phosphorus, monolayer semiconducting transition metal dichalcogenides and hBN range from 0 to 6 eV. These isolated atomic planes can be reassembled into hybrid heterostructures made layer by layer in a precisely chosen sequence. Thus, the electronic properties of 2D materials can be engineered by van der Waals stacking, and the interlayer coupling can be tuned, which opens up avenues for creating new material systems with rich functionalities and novel physical properties. Early studies suggest that van der Waals stacked 2D materials work exceptionally well, dramatically enriching the optoelectronics applications of 2D materials. Here we review recent progress in van der Waals stacked 2D materials, and discuss their potential applications in optoelectronics.

  12. Unitary quantum lattice gas representation of 2D quantum turbulence

    NASA Astrophysics Data System (ADS)

    Zhang, Bo; Vahala, George; Vahala, Linda; Soe, Min

    2011-05-01

    Quantum vortex structures and energy cascades are examined for two dimensional quantum turbulence (2D QT) using a special unitary evolution algorithm. The qubit lattice gas (QLG) algorithm, is employed to simulate the weakly-coupled Bose-Einstein condensate (BEC) governed by the Gross-Pitaevskii (GP) equation. A parameter regime is uncovered in which, as in 3D QT, there is a very short Poincare recurrence time. This short recurrence time is destroyed as the nonlinear interaction energy is increased. Energy cascades for 2D QT are considered to examine whether 2D QT exhibits the inverse cascades of 2D classical turbulence. In the parameter regime considered, the spectra analysis reveals no such dual cascades---dual cascades being a hallmark of 2D classical turbulence.

  13. CYP2D6 polymorphism in patients with eating disorders.

    PubMed

    Peñas-Lledó, E M; Dorado, P; Agüera, Z; Gratacós, M; Estivill, X; Fernández-Aranda, F; Llerena, A

    2012-04-01

    CYP2D6 polymorphism is associated with variability in drug response, endogenous metabolism (that is, serotonin), personality, neurocognition and psychopathology. The relationship between CYP2D6 genetic polymorphism and the risk of eating disorders (ED) was analyzed in 267 patients with ED and in 285 controls. A difference in the CYP2D6 active allele distribution was found between these groups. Women carrying more than two active genes (ultrarapid metabolizers) (7.5 vs 4.6%) or two (67 vs 58.9%) active genes were more frequent among patients with ED, whereas those with one (20.6 vs 30.2%) or zero active genes (4.9 vs 6.3%) were more frequent among controls (P<0.05). Although further research is needed, present findings suggest an association between CYP2D6 and ED. CYP2D6 allele distribution in patients with ED seems related to increased enzyme activity. PMID:20877302

  14. 2D materials and van der Waals heterostructures.

    PubMed

    Novoselov, K S; Mishchenko, A; Carvalho, A; Castro Neto, A H

    2016-07-29

    The physics of two-dimensional (2D) materials and heterostructures based on such crystals has been developing extremely fast. With these new materials, truly 2D physics has begun to appear (for instance, the absence of long-range order, 2D excitons, commensurate-incommensurate transition, etc.). Novel heterostructure devices--such as tunneling transistors, resonant tunneling diodes, and light-emitting diodes--are also starting to emerge. Composed from individual 2D crystals, such devices use the properties of those materials to create functionalities that are not accessible in other heterostructures. Here we review the properties of novel 2D crystals and examine how their properties are used in new heterostructure devices. PMID:27471306

  15. The Effect of Cumulus Cloud Field Anisotropy on Domain-Averaged Solar Fluxes and Atmospheric Heating Rates

    NASA Technical Reports Server (NTRS)

    Hinkelman, Laura M.; Evans, K. Franklin; Clothiaux, Eugene E.; Ackerman, Thomas P.; Stackhouse, Paul W., Jr.

    2006-01-01

    Cumulus clouds can become tilted or elongated in the presence of wind shear. Nevertheless, most studies of the interaction of cumulus clouds and radiation have assumed these clouds to be isotropic. This paper describes an investigation of the effect of fair-weather cumulus cloud field anisotropy on domain-averaged solar fluxes and atmospheric heating rate profiles. A stochastic field generation algorithm was used to produce twenty three-dimensional liquid water content fields based on the statistical properties of cloud scenes from a large eddy simulation. Progressively greater degrees of x-z plane tilting and horizontal stretching were imposed on each of these scenes, so that an ensemble of scenes was produced for each level of distortion. The resulting scenes were used as input to a three-dimensional Monte Carlo radiative transfer model. Domain-average transmission, reflection, and absorption of broadband solar radiation were computed for each scene along with the average heating rate profile. Both tilt and horizontal stretching were found to significantly affect calculated fluxes, with the amount and sign of flux differences depending strongly on sun position relative to cloud distortion geometry. The mechanisms by which anisotropy interacts with solar fluxes were investigated by comparisons to independent pixel approximation and tilted independent pixel approximation computations for the same scenes. Cumulus anisotropy was found to most strongly impact solar radiative transfer by changing the effective cloud fraction, i.e., the cloud fraction when the field is projected on a surface perpendicular to the direction of the incident solar beam.

  16. Effects of needle tip bevel and aspiration procedure on the morphology and developmental capacity of bovine compact cumulus oocyte complexes.

    PubMed

    Bols, P E; Ysebaert, M T; Van Soom, A; de Kruif, A

    1997-04-15

    Effects of the needle tip bevel and the aspiration procedure on the morphology of cumulusoocyte-complexes (COCs) and the developmental capacity of the oocytes after IVF were studied in 2 in vitro oocyte pick-up (OPU) simulations using a disposable ovum pick-up needle guidance system. In Experiment 1, the influence of the length of the needle bevel was investigated using a short and a long bevelled 20-g disposable needle. After being aspirated from slaughterhouse ovaries, the retrieved COCs were divided into 3 categories: 1) oocytes surrounded by a compact cumulus, 2) oocytes with an expanded cumulus, 3) partially naked oocytes. In Experiment 2, the influence of 5 different levels of aspiration vacuum for 3 different needle diameters (18-g, 19-g, 20-g) and 2 different needle bevels (long, short) was tested on the recovery and on the morphology of the cumulus investment of a fixed number of previously scored compact cumulus oocytes complexes (CCOCs), retrieved after slicing slaughterhouse ovaries. The re-retrieved COCs were allocated to Categories 1 and 3. The results show that the length of the needle bevel has a significant effect on oocyte recovery, in favor of the long-bevelled needle. As soon as higher aspiration vacua are used, a decrease of the number of CCOCs can be observed, which is less prominent for the short-bevelled needle compared to the long-bevelled one. The final number of blastocysts is similar for both needle types. In Experiment 2, the disposable needle system proved to be highly effective since nearly 80% of the CCOCs were retrieved. At low aspiration vacuum, up to 90% of the CCOCs withstand the aspiration procedure undamaged. Increasing the aspiration vacuum results in a decrease of the number of CCOCs, which is less pronounced using thinner needles. Averaged over all needle types, the prevalence of blastocysts expressed relative to the number of recovered oocytes decreases with higher aspiration vacuum. PMID:16728071

  17. Prolactin and growth hormone affect metaphase-II chromosomes in aging oocytes via cumulus cells using similar signaling pathways

    PubMed Central

    Lebedeva, Irina Y.; Singina, Galina N.; Lopukhov, Alexander V.; Shedova, Ekaterina N.; Zinovieva, Natalia A.

    2015-01-01

    General senescence of the adult organism is closely connected with reproductive one. Meanwhile, the age-related reduction in the female fertility is primarily associated with a decline in the gamete quality. Molecular and cellular changes in oocytes of old mammalian females are very similar to those occurring during aging of matured ova of their young counterparts, suggesting similarities in underlying mechanisms. The aim of the present work was to study actions of two related pituitary hormones, prolactin (PRL) and growth hormone (GH), on age-associated modifications of metaphase-II (M-II) chromosomes in bovine oocytes using a model of the prolonged culture. We analyzed: (1) effects of PRL and GH on abnormal changes in the chromosome morphology in aging matured oocytes and the role of cumulus cells in these effects and (2) signaling pathways involved in the hormone actions. During the prolonged culture of oocytes, a gradual rise in the frequency of destructive modifications of M-II chromosomes was revealed. In the case of cumulus-enclosed oocytes (CEOs), PRL and GH exerted dose-dependent biphasic effects on the frequency of these modifications. Both PRL (50 ng/ml) and GH (10 ng/ml) decelerated the abnormal chromosome changes in CEOs, but did not affect the chromosome configuration in denuded oocytes. Concurrently, the presence of PRL and GH receptors in cumulus cells surrounding matured oocytes was demonstrated. Attenuating effects of both hormones on the chromosome modifications in aging CEOs were abolished by PP2 (an inhibitor of Src-family tyrosine kinases), triciribine (an inhibitor of Akt kinase), and calphostin C (a protein kinase C inhibitor). Our findings indicate that PRL and GH can exert the similar decelerating action on age-associated alterations in the M-II chromosome morphology in bovine ova, which is mediated by cumulus cells and may be related to activation of Src-family tyrosine kinases as well as Akt- and protein kinase C-dependent signal

  18. Simulation of the Summer Monsoon Rainfall over East Asia using the NCEP GFS Cumulus Parameterization at Different Horizontal Resolutions

    SciTech Connect

    Lim, Kyo-Sun; Hong, Song You; Yoon, Jin-Ho; Han, Jongil

    2014-10-01

    The most recent version of Simplified Arakawa-Schubert (SAS) cumulus scheme in National Center for Environmental Prediction (NCEP) Global Forecast System (GFS) (GFS SAS) has been implemented into the Weather and Research Forecasting (WRF) model with a modification of triggering condition and convective mass flux to become depending on model’s horizontal grid spacing. East Asian Summer Monsoon of 2006 from June to August is selected to evaluate the performance of the modified GFS SAS scheme. Simulated monsoon rainfall with the modified GFS SAS scheme shows better agreement with observation compared to the original GFS SAS scheme. The original GFS SAS scheme simulates the similar ratio of subgrid-scale precipitation, which is calculated from a cumulus scheme, against total precipitation regardless of model’s horizontal grid spacing. This is counter-intuitive because the portion of resolved clouds in a grid box should be increased as the model grid spacing decreases. This counter-intuitive behavior of the original GFS SAS scheme is alleviated by the modified GFS SAS scheme. Further, three different cumulus schemes (Grell and Freitas, Kain and Fritsch, and Betts-Miller-Janjic) are chosen to investigate the role of a horizontal resolution on simulated monsoon rainfall. The performance of high-resolution modeling is not always enhanced as the spatial resolution becomes higher. Even though improvement of probability density function of rain rate and long wave fluxes by the higher-resolution simulation is robust regardless of a choice of cumulus parameterization scheme, the overall skill score of surface rainfall is not monotonically increasing with spatial resolution.

  19. Competence Classification of Cumulus and Granulosa Cell Transcriptome in Embryos Matched by Morphology and Female Age

    PubMed Central

    Thuesen, Lea Langhoff; Andersen, Claus Yding; Nyboe-Andersen, Anders; Ziebe, Søren; Winther, Ole; Grøndahl, Marie Louise

    2016-01-01

    Objective By focussing on differences in the mural granulosa cell (MGC) and cumulus cell (CC) transcriptomes from follicles resulting in competent (live birth) and non-competent (no pregnancy) oocytes the study aims on defining a competence classifier expression profile in the two cellular compartments. Design: A case-control study. Setting: University based facilities for clinical services and research. Patients: MGC and CC samples from 60 women undergoing IVF treatment following the long GnRH-agonist protocol were collected. Samples from 16 oocytes where live birth was achieved and 16 age- and embryo morphology matched incompetent oocytes were included in the study. Methods MGC and CC were isolated immediately after oocyte retrieval. From the 16 competent and non-competent follicles, mRNA was extracted and expression profile generated on the Human Gene 1.0 ST Affymetrix array. Live birth prediction analysis using machine learning algorithms (support vector machines) with performance estimation by leave-one-out cross validation and independent validation on an external data set. Results We defined a signature of 30 genes expressed in CC predictive of live birth. This live birth prediction model had an accuracy of 81%, a sensitivity of 0.83, a specificity of 0.80, a positive predictive value of 0.77, and a negative predictive value of 0.86. Receiver operating characteristic analysis found an area under the curve of 0.86, significantly greater than random chance. When applied on 3 external data sets with the end-point outcome measure of blastocyst formation, the signature resulted in 62%, 75% and 88% accuracy, respectively. The genes in the classifier are primarily connected to apoptosis and involvement in formation of extracellular matrix. We were not able to define a robust MGC classifier signature that could classify live birth with accuracy above random chance level. Conclusion We have developed a cumulus cell classifier, which showed a promising performance on

  20. Tropical Cumulus Convection and Upward Propagating Waves in Middle Atmospheric GCMs

    NASA Technical Reports Server (NTRS)

    Horinouchi, T.; Pawson, S.; Shibata, K.; Langematz, U.; Manzini, E.; Giorgetta, M. A.; Sassi, F.; Wilson, R. J.; Hamilton, K. P.; deGranpre, J.; Atlas, Robert (Technical Monitor)

    2002-01-01

    It is recognized that the resolved tropical wave spectrum can vary considerably between general circulation models (GCMs) and that these differences can have an important impact on the simulated climate. A comprehensive comparison of the waves is presented for the December-January-February period using high-frequency (three-hourly) data archives from eight GCMs and one simple model participating in the GCM Reality Intercomparison Project for SPARC (GRIPS). Quantitative measures of the structure and causes of the wavenumber-frequency structure of resolved waves and their impacts on the climate are given. Space-time spectral analysis reveals that the wave spectrum throughout the middle atmosphere is linked to variability of convective precipitation, which is determined by the parameterized convection. The variability of the precipitation spectrum differs by more than an order of magnitude between the models, with additional changes in the spectral distribution (especially the frequency). These differences can be explained primarily by the choice of different, cumulus par amet erizations: quasi-equilibrium mass-flux schemes tend to produce small variability, while the moist-convective adjustment scheme is most active. Comparison with observational estimates of precipitation variability suggests that the model values are scattered around the truth. This result indicates that a significant portion of the forcing of the equatorial quasi-biennial oscillation (QBO) is provided by waves with scales that are not resolved in present-day GCMs, since only the moist convective adjustment scheme (which has the largest transient variability) can force a QBO in models that have no parameterization of non-stationary gravity waves. Parameterized cumulus convection also impacts the nonmigrating tides in the equatorial region. In most of the models, momentum transport by diurnal nonmigrating tides in the mesosphere is larger than that by Kelvin waves, being more significant than has

  1. Targeted fluorescence imaging enhanced by 2D materials: a comparison between 2D MoS2 and graphene oxide.

    PubMed

    Xie, Donghao; Ji, Ding-Kun; Zhang, Yue; Cao, Jun; Zheng, Hu; Liu, Lin; Zang, Yi; Li, Jia; Chen, Guo-Rong; James, Tony D; He, Xiao-Peng

    2016-08-01

    Here we demonstrate that 2D MoS2 can enhance the receptor-targeting and imaging ability of a fluorophore-labelled ligand. The 2D MoS2 has an enhanced working concentration range when compared with graphene oxide, resulting in the improved imaging of both cell and tissue samples. PMID:27378648

  2. 2D vs. 3D mammography observer study

    NASA Astrophysics Data System (ADS)

    Fernandez, James Reza F.; Hovanessian-Larsen, Linda; Liu, Brent

    2011-03-01

    Breast cancer is the most common type of non-skin cancer in women. 2D mammography is a screening tool to aid in the early detection of breast cancer, but has diagnostic limitations of overlapping tissues, especially in dense breasts. 3D mammography has the potential to improve detection outcomes by increasing specificity, and a new 3D screening tool with a 3D display for mammography aims to improve performance and efficiency as compared to 2D mammography. An observer study using a mammography phantom was performed to compare traditional 2D mammography with this ne 3D mammography technique. In comparing 3D and 2D mammography there was no difference in calcification detection, and mass detection was better in 2D as compared to 3D. There was a significant decrease in reading time for masses, calcifications, and normals in 3D compared to 2D, however, as well as more favorable confidence levels in reading normal cases. Given the limitations of the mammography phantom used, however, a clearer picture in comparing 3D and 2D mammography may be better acquired with the incorporation of human studies in the future.

  3. Efficient 2D MRI relaxometry using compressed sensing

    NASA Astrophysics Data System (ADS)

    Bai, Ruiliang; Cloninger, Alexander; Czaja, Wojciech; Basser, Peter J.

    2015-06-01

    Potential applications of 2D relaxation spectrum NMR and MRI to characterize complex water dynamics (e.g., compartmental exchange) in biology and other disciplines have increased in recent years. However, the large amount of data and long MR acquisition times required for conventional 2D MR relaxometry limits its applicability for in vivo preclinical and clinical MRI. We present a new MR pipeline for 2D relaxometry that incorporates compressed sensing (CS) as a means to vastly reduce the amount of 2D relaxation data needed for material and tissue characterization without compromising data quality. Unlike the conventional CS reconstruction in the Fourier space (k-space), the proposed CS algorithm is directly applied onto the Laplace space (the joint 2D relaxation data) without compressing k-space to reduce the amount of data required for 2D relaxation spectra. This framework is validated using synthetic data, with NMR data acquired in a well-characterized urea/water phantom, and on fixed porcine spinal cord tissue. The quality of the CS-reconstructed spectra was comparable to that of the conventional 2D relaxation spectra, as assessed using global correlation, local contrast between peaks, peak amplitude and relaxation parameters, etc. This result brings this important type of contrast closer to being realized in preclinical, clinical, and other applications.

  4. Using microsoft excel applications in the graduate intern program at Goddard Space Flight Center. M.S. Thesis

    NASA Technical Reports Server (NTRS)

    Antoine, Lisa

    1992-01-01

    An outline of the Project Operations Branch at Goddard Space Flight Center is presented that describes the management of the division and each subgroup's responsibility. The paper further describes the development of software tools for the Macintosh personal computer, and their impending implementation. A detailed step by step procedure is given for using these software tools.

  5. NKG2D receptor and its ligands in host defense

    PubMed Central

    Lanier, Lewis L.

    2015-01-01

    NKG2D is an activating receptor expressed on the surface of natural killer (NK) cells, CD8+ T cells, and subsets of CD4+ T cells, iNKT cells, and γδ T cells. In humans NKG2D transmits signals by its association with the DAP10 adapter subunit and in mice alternatively spliced isoforms transmit signals either using DAP10 or DAP12 adapter subunits. Although NKG2D is encoded by a highly conserved gene (KLRK1) with limited polymorphism, the receptor recognizes an extensive repertoire of ligands, encoded by at least 8 genes in humans (MICA, MICB, RAET1E, RAET1G, RAET1H, RAET1I, RAET1L, and RAET1N), some with extensive allelic polymorphism. Expression of the NKG2D ligands is tightly regulated at the level of transcription, translation, and post-translation. In general healthy adult tissues do not express NKG2D glycoproteins on the cell surface, but these ligands can be induced by hyper-proliferation and transformation, as well as when cells are infected by pathogens. Thus, the NKG2D pathway serves a mechanism for the immune system to detect and eliminate cells that have undergone “stress”. Viruses and tumor cells have devised numerous strategies to evade detection by the NKG2D surveillance system and diversification of the NKG2D ligand genes likely has been driven by selective pressures imposed by pathogens. NKG2D provides an attractive target for therapeutics in the treatment of infectious diseases, cancer, and autoimmune diseases. PMID:26041808

  6. Lightning Optical Pulse Statistics from Storm Overflights During the Altus Cumulus Electrification Study

    NASA Technical Reports Server (NTRS)

    Mach, D. M.; Blakeslee, R. J.; Bailey, J. C.; Farrell, W. M.; Goldberg, R. A.; Desch, M. D.; Houser, J. G.

    2004-01-01

    The Altus Cumulus Electrification Study (ACES) was conducted during the month of August, 2002 in an area near Key West, Florida. One of the goals of this uninhabited aerial vehicle (UAV) study was to collect time resolved optical pulse data from thunderstorms. During the month long campaign, we acquired 5294 lightning generated optical pulses. Most of these observations were made while close to the top of the storms. We divided our data into two amplitude groups based on prior NASA U2 aircraft optical data and our pulse characteristics. The group of large pulses with radiance greater than 2.1 mW /sq m sr had mean and median 10 - 10% optical pulse widths of 765 and 735 microns respectively, the 50-50% pulse widths of 396 and 355 microns respectively, and 10-90% rise times of 290 and 260 microns. These values are very similar to the previous U2 based optical results The other group of pulses consisting of slightly more than a quarter of the total pulses observed had radiances less than the minimum values detected in the U2 study. The small pulses were narrower than the large pulses with 5040% mean and median values of 198 and 160 ps respectively. Only 12 % of the flashes contained only small pulses, minimizing the impact of this data on the estimates of detection efficiencies of the orbital instruments, the Lightning Imaging Sensor and Optical Transient Detector.

  7. Sensitivity of diurnal variation in simulated precipitation during East Asian summer monsoon to cumulus parameterization schemes

    NASA Astrophysics Data System (ADS)

    Choi, In-Jin; Jin, Emilia Kyung; Han, Ji-Young; Kim, So-Young; Kwon, Young

    2015-12-01

    The capability to simulate the diurnal variation of precipitation over East Asia region during the summertime of 2011 is investigated using five different cumulus parameterization schemes with the Weather Research and Forecasting model. A semidiurnal cycle with a 12 h interval over land and a diurnal cycle with a 24 h interval over ocean are commonly found in all simulations, consistent with the observed diurnal cycle. Two observed dominant peaks in the early morning and afternoon are reproduced in all simulations. With overestimated precipitation rate, however, the simulated afternoon peaks occur earlier than the observed peaks by 2 h for the Kain-Fritsch (KF) and Simplified Arakawa-Schubert schemes, and by 3 h for the Betts-Miller-Janjić and Tiedtke schemes. The overestimation of simulated precipitation frequency leads to amplitude and phase errors in the precipitation rate, and the early peak time of simulated precipitation intensity intensifies the phase error in the simulation over land. The KF scheme with alternative trigger function (KFtr) based on moisture advection provides slightly better results in terms of alleviating the overestimated precipitation rate and frequency and delaying the afternoon peaks. Additional sensitivity simulations based on the change of temperature perturbation in the trigger function of the KF and KFtr schemes demonstrate the afternoon peak tends to be delayed as temperature perturbation decreases, implying the significant role of convective initiation frequency in determining diurnal peaks of precipitation. Modulation of temperature perturbation alleviates the precipitation frequency bias, while it could not resolve the precipitation intensity bias.

  8. Do Shallow Cumulus Clouds have the Potential to Trigger Secondary Circulations Via Shading?

    NASA Astrophysics Data System (ADS)

    Gronemeier, Tobias; Kanani-Sühring, Farah; Raasch, Siegfried

    2016-06-01

    The effects on the convective boundary layer (CBL) of shading due to shallow cumulus clouds are investigated. The main question is to see whether clouds are able to produce secondary circulations by shading of the surface (dynamic heterogeneities) and how these dynamic heterogeneities interact with static heterogeneities in terms of the production of secondary circulations. Also the effects of cloud shadows on cloud-field characteristics are analyzed. The effects are studied using large-eddy simulations of a cloud-topped CBL with an idealized surface. Over a homogeneous surface, shadows trigger secondary circulations with different strengths depending on the solar zenith angle θ, with large θ favouring the development of secondary circulations. Over a static heterogeneous surface with a simple striped pattern, the strength of secondary circulations is effectively reduced by dynamic heterogeneities at small θ. At large θ, however, the effect on secondary circulations depends on the orientation of the striped static heterogeneities to the shadow-casting direction of the clouds. The influence of shadows is only small if they are cast perpendicular to the striped heterogeneity, but if stripes and the shadow-casting direction are parallel, secondary circulations are reduced in strength also for large θ. Shadow effects on the cloud-field characteristics vary with θ as well. The results show that small θ favours the development of small clouds with a reduced lifetime while large θ promotes the development of larger clouds with an extended lifetime compared to non-shading clouds.

  9. A Comparison of Cumulus Parameterizations in Idealized Sea-Breeze Simulations

    NASA Technical Reports Server (NTRS)

    Cohen, Charles; Arnold, James E. (Technical Monitor)

    2001-01-01

    Four cumulus parameterizations in the Penn State-NCAR model MM5 are compared in idealized sea-breeze simulations, with the aim of discovering why they work as they do. The most realistic results appear to be those using the Kain-Fritsch scheme. Rainfall is significantly delayed with the Betts-Miller-Janjic scheme, due to the method of computing the reference sounding. This method can be corrected, but downdrafts should be added in a physically realistic manner. Even without downdrafts, a corrected version of the BMJ scheme produces nearly the same timing and location of deep convection as the KF scheme, despite the very different physics. In order to simulate the correct timing of the rainfall, a minimum amount of mass is required in the layer that is the source of a parameterized updraft. The Grell parameterization, in the present simulation, always derives the updraft from the top of the mixed layer, where vertical advection predominates over horizontal advection in increasing the moist static energy. This makes the application of the quasi-equilibrium closure more correct than it would be if the updrafts were always derived from the most unstable layer, but it evades the question of whether or not horizontal advection generates instability. Using different physics, the parameterizations produce significantly different cloud-top heights.

  10. On the sensitivity of droplet size relative dispersion to warm cumulus cloud evolution

    NASA Astrophysics Data System (ADS)

    Tas, E.; Koren, I.; Altaratz, O.

    2012-07-01

    Relative dispersion (ɛ), defined as the ratio between cloud droplet size distribution width (σ) and cloud droplet average radius (), is a key factor used to parameterize various cloud processes in global circulation models (GCMs) and bulk microphysical scheme models (BSMs). Recent studies indicate that the impact of aerosol loading (N) and atmospheric thermodynamic conditions on ɛ are far from fully understood. Currently, a fixed value per hydrometeor type is used in most BSMs and GCMs, which imposes significant limitations on our ability to model and predict cloud processes and their impact on the environment, on regional to global scales. In this study, we use a detailed bin microphysics single cloud model to investigate the combined impact of atmospheric thermodynamic conditions and N on ɛ, in warm cumulus clouds. As initial conditions, we used different lapse-rates combined with 8 scenarios of aerosol loading, representing very clean (N = 25 cm-3) to heavily polluted (N = 1600 cm-3) conditions. Moreover, the results are analyzed per cloud evolutionary stage according to the dominance of microphysical processes. The use of this method indicated a different pattern of ɛ at each stage. Specifically, during the mature stage fitting of ɛ to rv is relatively resilient to changes in the environmental conditions. Such findings suggest a new view of the effect of aerosols on clouds, via changes in the cloud evolution patterns and a new approach to parameterization of ɛ based on rv, which can significantly improve the prediction of cloud processes by GCMs and BSMs.

  11. Comparative gene expression profiling in human cumulus cells according to ovarian gonadotropin treatments.

    PubMed

    Assou, Said; Haouzi, Delphine; Dechaud, Hervé; Gala, Anna; Ferrières, Alice; Hamamah, Samir

    2013-01-01

    In in vitro fertilization cycles, both HP-hMG and rFSH gonadotropin treatments are widely used to control human follicle development. The objectives of this study are (i) to characterize and compare gene expression profiles in cumulus cells (CCs) of periovulatory follicles obtained from patients stimulated with HP-hMG or rFSH in a GnRH antagonist cycle and (ii) to examine their relationship with in vitro embryo development, using Human Genome U133 Plus 2.0 microarrays. Genes that were upregulated in HP-hMG-treated CCs are involved in lipid metabolism (GM2A) and cell-to-cell interactions (GJA5). Conversely, genes upregulated in rFSH-treated CCs are implicated in cell assembly and organization (COL1A1 and COL3A1). Interestingly, some genes specific to each gonadotropin treatment (NPY1R and GM2A for HP-hMG; GREM1 and OSBPL6 for rFSH) were associated with day 3 embryo quality and blastocyst grade at day 5, while others (STC2 and PTX3) were related to in vitro embryo quality in both gonadotropin treatments. These genes may prove valuable as biomarkers of in vitro embryo quality. PMID:24151596

  12. Transcriptomic Analysis and Meta-Analysis of Human Granulosa and Cumulus Cells

    PubMed Central

    Burnik Papler, Tanja; Vrtacnik Bokal, Eda; Maver, Ales; Kopitar, Andreja Natasa; Lovrečić, Luca

    2015-01-01

    Specific gene expression in oocytes and its surrounding cumulus (CC) and granulosa (GC) cells is needed for successful folliculogenesis and oocyte maturation. The aim of the present study was to compare genome-wide gene expression and biological functions of human GC and CC. Individual GC and CC were derived from 37 women undergoing IVF procedures. Gene expression analysis was performed using microarrays, followed by a meta-analysis. Results were validated using quantitative real-time PCR. There were 6029 differentially expressed genes (q < 10−4); of which 650 genes had a log2 FC ≥ 2. After the meta-analysis there were 3156 genes differentially expressed. Among these there were genes that have previously not been reported in human somatic follicular cells, like prokineticin 2 (PROK2), higher expressed in GC, and pregnancy up-regulated nonubiquitous CaM kinase (PNCK), higher expressed in CC. Pathways like inflammatory response and angiogenesis were enriched in GC, whereas in CC, cell differentiation and multicellular organismal development were among enriched pathways. In conclusion, transcriptomes of GC and CC as well as biological functions, are distinctive for each cell subpopulation. By describing novel genes like PROK2 and PNCK, expressed in GC and CC, we upgraded the existing data on human follicular biology. PMID:26313571

  13. The effect of cumulus cloud field anisotropy on solar radiative fluxes and atmospheric heating rates

    NASA Astrophysics Data System (ADS)

    Hinkelman, Laura M.

    The effect of fair-weather cumulus cloud field anisotropy on domain average surface fluxes and atmospheric heating profiles was studied. Causes of anisotropy were investigated using a large-eddy simulation (LES) model. Cloud formation under a variety of environmental conditions was simulated and the degree of anisotropy in the output fields was calculated. Wind shear was found to be the single greatest factor in the development of both vertically tilted and horizontally stretched cloud structures. A stochastic field generation algorithm was used to produce twenty three-dimensional liquid water content fields based on the statistical properties of the LES cloud scenes. Progressively greater degrees of tilt and stretching were imposed on each of these scenes, so that an ensemble of scenes were produced for each level of distortion. The resulting scenes were used as input to a three-dimensional Monte Carlo model. Domain-average transmission, reflection, and absorption of broadband solar radiation were computed for each scene along with the average heating rate profile. Both tilt and horizontal stretching were found to significantly affect calculated fluxes, with the amount and sign of flux differences depending strongly on sun position relative to cloud distortion geometry. For nearly all solar geometries, domain-averaged fluxes and atmospheric heating rate profiles calculated using the Independent Pixel Approximation differed substantially from the corresponding three-dimensional Monte Carlo results.

  14. From large-eddy simulation to multi-UAVs sampling of shallow cumulus clouds

    NASA Astrophysics Data System (ADS)

    Lamraoui, Fayçal; Roberts, Greg; Burnet, Frédéric

    2016-04-01

    In-situ sampling of clouds that can provide simultaneous measurements at satisfying spatio-temporal resolutions to capture 3D small scale physical processes continues to present challenges. This project (SKYSCANNER) aims at bringing together cloud sampling strategies using a swarm of unmanned aerial vehicles (UAVs) based on Large-eddy simulation (LES). The multi-UAV-based field campaigns with a personalized sampling strategy for individual clouds and cloud fields will significantly improve the understanding of the unresolved cloud physical processes. An extensive set of LES experiments for case studies from ARM-SGP site have been performed using MesoNH model at high resolutions down to 10 m. The carried out simulations led to establishing a macroscopic model that quantifies the interrelationship between micro- and macrophysical properties of shallow convective clouds. Both the geometry and evolution of individual clouds are critical to multi-UAV cloud sampling and path planning. The preliminary findings of the current project reveal several linear relationships that associate many cloud geometric parameters to cloud related meteorological variables. In addition, the horizontal wind speed indicates a proportional impact on cloud number concentration as well as triggering and prolonging the occurrence of cumulus clouds. In the framework of the joint collaboration that involves a Multidisciplinary Team (including institutes specializing in aviation, robotics and atmospheric science), this model will be a reference point for multi-UAVs sampling strategies and path planning.

  15. Airborne observations of electric fields around growing and decaying cumulus clouds

    NASA Technical Reports Server (NTRS)

    Giori, K. L.; Nanevicz, J. E.

    1991-01-01

    Airborne electric field data were gathered in an atmospheric electrification study near Cape Canaveral, FL. A Learjet 36A was instrumented with eight electric field meters (mills) and five different particle probes. The local electric field enhancements at each field mill site were determined under lab conditions and verified using in-flight data. The overdetermined system of eight equations (one for each field mill) was solved using a weighted least squares algorithm to compute the magnitude and direction of the ambient electric field. The signal processing system allowed the measured data to be expressed in terms of earth coordinates, regardless of the attitude of the aircraft. Thus, it was possible to take maximum advantage of the Learjet's speed and maneuverability in studying the electric field structure in the vicinity of the clouds. Data gathered while circling just outside the boundary of a growing cumulus cloud show a nonsymmetric pattern of electric field strength. Field intensity grew rapidly over a period of less than 10 minutes. The observed direction of the ambient electric field vector can be explained by an ascending motion of the charge centers of a classic tripole model of a thunderstorm.

  16. Integrated cumulus ensemble and turbulence (ICET): An integrated parameterization system for general circulation models (GCMs)

    SciTech Connect

    Evans, J.L.; Frank, W.M.; Young, G.S.

    1996-04-01

    Successful simulations of the global circulation and climate require accurate representation of the properties of shallow and deep convective clouds, stable-layer clouds, and the interactions between various cloud types, the boundary layer, and the radiative fluxes. Each of these phenomena play an important role in the global energy balance, and each must be parameterized in a global climate model. These processes are highly interactive. One major problem limiting the accuracy of parameterizations of clouds and other processes in general circulation models (GCMs) is that most of the parameterization packages are not linked with a common physical basis. Further, these schemes have not, in general, been rigorously verified against observations adequate to the task of resolving subgrid-scale effects. To address these problems, we are designing a new Integrated Cumulus Ensemble and Turbulence (ICET) parameterization scheme, installing it in a climate model (CCM2), and evaluating the performance of the new scheme using data from Atmospheric Radiation Measurement (ARM) Program Cloud and Radiation Testbed (CART) sites.

  17. Optimizing the Betts-Miller-Janjic cumulus parameterization with Intel Many Integrated Core (MIC) architecture

    NASA Astrophysics Data System (ADS)

    Huang, Melin; Huang, Bormin; Huang, Allen H.-L.

    2015-10-01

    The schemes of cumulus parameterization are responsible for the sub-grid-scale effects of convective and/or shallow clouds, and intended to represent vertical fluxes due to unresolved updrafts and downdrafts and compensating motion outside the clouds. Some schemes additionally provide cloud and precipitation field tendencies in the convective column, and momentum tendencies due to convective transport of momentum. The schemes all provide the convective component of surface rainfall. Betts-Miller-Janjic (BMJ) is one scheme to fulfill such purposes in the weather research and forecast (WRF) model. National Centers for Environmental Prediction (NCEP) has tried to optimize the BMJ scheme for operational application. As there are no interactions among horizontal grid points, this scheme is very suitable for parallel computation. With the advantage of Intel Xeon Phi Many Integrated Core (MIC) architecture, efficient parallelization and vectorization essentials, it allows us to optimize the BMJ scheme. If compared to the original code respectively running on one CPU socket (eight cores) and on one CPU core with Intel Xeon E5-2670, the MIC-based optimization of this scheme running on Xeon Phi coprocessor 7120P improves the performance by 2.4x and 17.0x, respectively.

  18. Long-term Statistics of Continental Cumuli: Does Aerosol Trigger Cumulus Variability?

    SciTech Connect

    Kassianov, Evgueni I.; Berg, Larry K.; McFarlane, Sally A.; Flynn, Connor J.; Turner, David D.

    2009-02-01

    Atmospheric aerosols may control the formation, maintenance, and dissipation of cumuli by changing their microphysics. Recent observational and modeling results exist both in support and against strong potential impacts of aerosol [1-3]. Typically, the aerosol impact on water clouds has been investigated for regions with high aerosol loading and/or large atmospheric moisture [4]. Can we provide observational evidence of the aerosol-cloud relationship for a relatively dry continental region with low/moderate aerosol burden? To address this question, we revisit the aerosol-cloud relationship at the Atmospheric Radiation Measurement (ARM) Climate Research Facility (ACRF) Southern Great Plains (SGP) site. In comparison with highly polluted regions, the SGP site is characterized by relatively small-to-moderate aerosol loading. Also, moisture content is small-to-moderate (compared to marine and coastal regions) for the SGP site. Because cumulus clouds have important impacts on climate forcing estimations [5] and are susceptible to aerosol effects [6], we focus on fair-weather cumuli (FWC) and their association with aerosol concentration and other potentially important factors. This association is investigated using a new 8-year aerosol and cloud climatology (2000-2007) developed with collocated and coincident surface and satellite observations.

  19. Rainfall results of the Florida Area Cumulus Experiment, 1970-76

    NASA Technical Reports Server (NTRS)

    Woodley, W. L.; Jordan, J.; Barnston, A.; Simpson, J.; Biondini, R.; Flueck, J.

    1982-01-01

    The Florida Area Cumulus Experiment of 1970-76 (FACE-1) is a single-area, randomized, exploratory experiment to determine whether seeding cumuli for dynamic effects (dynamic seeding) can be used to augment convective rainfall over a substantial target area in south Florida. Rainfall is estimated using S-band radar observations after adjustment by raingages. The two primary response variables are rain volumes in the total target (TT) and in the floating target (FT), the most intensely treated portion of the target. The experimental unit is the day and the main observational period is the 6 h after initiation of treatment. Analyses without predictors suggest apparent increases in both the location and the dispersion characteristics of rainfall due to seeding in the FT and TT variables with substantial statistical support for the FT results and lesser statistical support for the TT results. Analyses of covariance using meteorologically meaningful predictor variables suggest a somewhat larger effect of seeding with stronger statistical support. These results are interpreted in terms of the FACE conceptual model.

  20. 2D constant-loss taper for mode conversion

    NASA Astrophysics Data System (ADS)

    Horth, Alexandre; Kashyap, Raman; Quitoriano, Nathaniel J.

    2015-03-01

    Proposed in this manuscript is a novel taper geometry, the constant-loss taper (CLT). This geometry is derived with 1D slabs of silicon embedded in silicon dioxide using coupled-mode theory (CMT). The efficiency of the CLT is compared to both linear and parabolic tapers using CMT and 2D finite-difference time-domain simulations. It is shown that over a short 2D, 4.45 μm long taper the CLT's mode conversion efficiency is ~90% which is 10% and 18% more efficient than a 2D parabolic or linear taper, respectively.

  1. Recent advances in 2D materials for photocatalysis

    NASA Astrophysics Data System (ADS)

    Luo, Bin; Liu, Gang; Wang, Lianzhou

    2016-03-01

    Two-dimensional (2D) materials have attracted increasing attention for photocatalytic applications because of their unique thickness dependent physical and chemical properties. This review gives a brief overview of the recent developments concerning the chemical synthesis and structural design of 2D materials at the nanoscale and their applications in photocatalytic areas. In particular, recent progress on the emerging strategies for tailoring 2D material-based photocatalysts to improve their photo-activity including elemental doping, heterostructure design and functional architecture assembly is discussed.

  2. Comparison of 2D and 3D gamma analyses

    SciTech Connect

    Pulliam, Kiley B.; Huang, Jessie Y.; Howell, Rebecca M.; Followill, David; Kry, Stephen F.; Bosca, Ryan; O’Daniel, Jennifer

    2014-02-15

    Purpose: As clinics begin to use 3D metrics for intensity-modulated radiation therapy (IMRT) quality assurance, it must be noted that these metrics will often produce results different from those produced by their 2D counterparts. 3D and 2D gamma analyses would be expected to produce different values, in part because of the different search space available. In the present investigation, the authors compared the results of 2D and 3D gamma analysis (where both datasets were generated in the same manner) for clinical treatment plans. Methods: Fifty IMRT plans were selected from the authors’ clinical database, and recalculated using Monte Carlo. Treatment planning system-calculated (“evaluated dose distributions”) and Monte Carlo-recalculated (“reference dose distributions”) dose distributions were compared using 2D and 3D gamma analysis. This analysis was performed using a variety of dose-difference (5%, 3%, 2%, and 1%) and distance-to-agreement (5, 3, 2, and 1 mm) acceptance criteria, low-dose thresholds (5%, 10%, and 15% of the prescription dose), and data grid sizes (1.0, 1.5, and 3.0 mm). Each comparison was evaluated to determine the average 2D and 3D gamma, lower 95th percentile gamma value, and percentage of pixels passing gamma. Results: The average gamma, lower 95th percentile gamma value, and percentage of passing pixels for each acceptance criterion demonstrated better agreement for 3D than for 2D analysis for every plan comparison. The average difference in the percentage of passing pixels between the 2D and 3D analyses with no low-dose threshold ranged from 0.9% to 2.1%. Similarly, using a low-dose threshold resulted in a difference between the mean 2D and 3D results, ranging from 0.8% to 1.5%. The authors observed no appreciable differences in gamma with changes in the data density (constant difference: 0.8% for 2D vs 3D). Conclusions: The authors found that 3D gamma analysis resulted in up to 2.9% more pixels passing than 2D analysis. It must

  3. Materials for Flexible, Stretchable Electronics: Graphene and 2D Materials

    NASA Astrophysics Data System (ADS)

    Kim, Sang Jin; Choi, Kyoungjun; Lee, Bora; Kim, Yuna; Hong, Byung Hee

    2015-07-01

    Recently, 2D materials have been intensively studied as emerging materials for future electronics, including flexible electronics, photonics, and electrochemical energy storage devices. Among representative 2D materials (such as graphene, boron nitride, and transition metal dichalcogenides) that exhibit extraordinary properties, graphene stands out in the flexible electronics field due to its combination of high electron mobility, high thermal conductivity, high specific surface area, high optical transparency, excellent mechanical flexibility, and environmental stability. This review covers the synthesis, transfer, and characterization methods of graphene and 2D materials and graphene's application to flexible devices as well as comparison with other competing materials.

  4. Recent developments in 2D layered inorganic nanomaterials for sensing

    NASA Astrophysics Data System (ADS)

    Kannan, Padmanathan Karthick; Late, Dattatray J.; Morgan, Hywel; Rout, Chandra Sekhar

    2015-08-01

    Two dimensional layered inorganic nanomaterials (2D-LINs) have recently attracted huge interest because of their unique thickness dependent physical and chemical properties and potential technological applications. The properties of these layered materials can be tuned via both physical and chemical processes. Some 2D layered inorganic nanomaterials like MoS2, WS2 and SnS2 have been recently developed and employed in various applications, including new sensors because of their layer-dependent electrical properties. This article presents a comprehensive overview of recent developments in the application of 2D layered inorganic nanomaterials as sensors. Some of the salient features of 2D materials for different sensing applications are discussed, including gas sensing, electrochemical sensing, SERS and biosensing, SERS sensing and photodetection. The working principles of the sensors are also discussed together with examples.

  5. 2. D Street facade and rear (east) blank wall of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. D Street facade and rear (east) blank wall of parking garage. Farther east is 408 8th Street (National Art And Frame Company). - PMI Parking Garage, 403-407 Ninth Street, Northwest, Washington, District of Columbia, DC

  6. Collective excitations in 2D hard-disc fluid.

    PubMed

    Huerta, Adrian; Bryk, Taras; Trokhymchuk, Andrij

    2015-07-01

    Collective dynamics of a two-dimensional (2D) hard-disc fluid was studied by molecular dynamics simulations in the range of packing fractions that covers states up to the freezing. Some striking features concerning collective excitations in this system were observed. In particular, the short-wavelength shear waves while being absent at low packing fractions were observed in the range of high packing fractions, just before the freezing transition in a 2D hard-disc fluid. In contrast, the so-called "positive sound dispersion" typically observed in dense Lennard-Jones-like fluids, was not detected for the 2D hard-disc fluid. The ratio of specific heats in the 2D hard-disc fluid shows a monotonic increase with density approaching the freezing, resembling in this way the similar behavior in the vicinity of the Widom line in the case of supercritical fluids. PMID:25595625

  7. Alloyed 2D Metal-Semiconductor Atomic Layer Junctions.

    PubMed

    Kim, Ah Ra; Kim, Yonghun; Nam, Jaewook; Chung, Hee-Suk; Kim, Dong Jae; Kwon, Jung-Dae; Park, Sang Won; Park, Jucheol; Choi, Sun Young; Lee, Byoung Hun; Park, Ji Hyeon; Lee, Kyu Hwan; Kim, Dong-Ho; Choi, Sung Mook; Ajayan, Pulickel M; Hahm, Myung Gwan; Cho, Byungjin

    2016-03-01

    Heterostructures of compositionally and electronically variant two-dimensional (2D) atomic layers are viable building blocks for ultrathin optoelectronic devices. We show that the composition of interfacial transition region between semiconducting WSe2 atomic layer channels and metallic NbSe2 contact layers can be engineered through interfacial doping with Nb atoms. WxNb1-xSe2 interfacial regions considerably lower the potential barrier height of the junction, significantly improving the performance of the corresponding WSe2-based field-effect transistor devices. The creation of such alloyed 2D junctions between dissimilar atomic layer domains could be the most important factor in controlling the electronic properties of 2D junctions and the design and fabrication of 2D atomic layer devices. PMID:26839956

  8. Technical Review of the UNET2D Hydraulic Model

    SciTech Connect

    Perkins, William A.; Richmond, Marshall C.

    2009-05-18

    The Kansas City District of the US Army Corps of Engineers is engaged in a broad range of river management projects that require knowledge of spatially-varied hydraulic conditions such as velocities and water surface elevations. This information is needed to design new structures, improve existing operations, and assess aquatic habitat. Two-dimensional (2D) depth-averaged numerical hydraulic models are a common tool that can be used to provide velocity and depth information. Kansas City District is currently using a specific 2D model, UNET2D, that has been developed to meet the needs of their river engineering applications. This report documents a tech- nical review of UNET2D.

  9. From weakly to strongly interacting 2D Fermi gases

    NASA Astrophysics Data System (ADS)

    Dyke, Paul; Fenech, Kristian; Lingham, Marcus; Peppler, Tyson; Hoinka, Sascha; Vale, Chris

    2014-05-01

    We study ultracold 2D Fermi gases of 6Li formed in a highly oblate trapping potential. The potential is generated by a cylindrically focused, blue detuned TEM01 mode laser beam. Weak magnetic field curvature provides highly harmonic confinement in the radial direction and we can readily produce single clouds with an aspect ratio of 230. Our experiments investigate the dimensional crossover from 3D to 2D for a two component Fermi gas in the Bose-Einstein Condensate to Bardeen Cooper Schrieffer crossover. Observation of an elbow in measurements of the cloud width vs. atom number is consistent with populating only the lowest transverse harmonic oscillator state for weak attractive interactions. This measurement is extended to the strongly interacting region using the broad Feshbach resonance at 832 G. We also report our progress towards measurement of the 2D equation of state for an interacting 2D Fermi gas via in-situ absorption imaging.

  10. Chemical vapour deposition: Transition metal carbides go 2D

    NASA Astrophysics Data System (ADS)

    Gogotsi, Yury

    2015-11-01

    The unique properties of 2D materials, such as graphene or transition metal dichalcogenides, have been attracting much attention in the past decade. Now, metallically conductive and even superconducting transition metal carbides are entering the game.

  11. Dominant 2D magnetic turbulence in the solar wind

    NASA Technical Reports Server (NTRS)

    Bieber, John W.; Wanner, Wolfgang; Matthaeus, William H.

    1995-01-01

    There have been recent suggestions that solar wind magnetic turbulence may be a composite of slab geometry (wavevector aligned with the mean magnetic field) and 2D geometry (wavevectors perpendicular to the mean field). We report results of two new tests of this hypothesis using Helios measurements of inertial ranged magnetic spectra in the solar wind. The first test is based upon a characteristic difference between perpendicular and parallel reduced power spectra which is expected for the 2D component but not for the slab component. The second test examines the dependence of power spectrum density upon the magnetic field angle (i.e., the angle between the mean magnetic field and the radial direction), a relationship which is expected to be in opposite directions for the slab and 2D components. Both tests support the presence of a dominant (approximately 85 percent by energy) 2D component in solar wind magnetic turbulence.

  12. Dominant 2D magnetic turbulence in the solar wind

    SciTech Connect

    Bieber, John W.; Wanner, Wolfgang; Matthaeus, William H.

    1996-07-20

    There have been recent suggestions that solar wind magnetic turbulence may be a composite of slab geometry (wavevectors aligned with the mean magnetic field) and 2D geometry (wavevectors perpendicular to the mean field). We report results of two new tests of this hypothesis using Helios measurements of mid-inertial range magnetic spectra in the solar wind. The first test is based upon a characteristic difference between reduced magnetic power spectra in the two different directions perpendicular to the mean field. Such a difference is expected for 2D geometry but not for slab geometry. The second test examines the dependence of power spectrum density upon the magnetic field angle (i.e., the angle between the mean magnetic field and the radial direction), a relationship which is expected to be in opposite directions for the slab and 2D components. Both tests support the presence of a dominant ({approx}85% by energy) 2D component in solar wind magnetic turbulence.

  13. Efficient framework for deformable 2D-3D registration

    NASA Astrophysics Data System (ADS)

    Fluck, Oliver; Aharon, Shmuel; Khamene, Ali

    2008-03-01

    Using 2D-3D registration it is possible to extract the body transformation between the coordinate systems of X-ray and volumetric CT images. Our initial motivation is the improvement of accuracy of external beam radiation therapy, an effective method for treating cancer, where CT data play a central role in radiation treatment planning. Rigid body transformation is used to compute the correct patient setup. The drawback of such approaches is that the rigidity assumption on the imaged object is not valid for most of the patient cases, mainly due to respiratory motion. In the present work, we address this limitation by proposing a flexible framework for deformable 2D-3D registration consisting of a learning phase incorporating 4D CT data sets and hardware accelerated free form DRR generation, 2D motion computation, and 2D-3D back projection.

  14. Cyclic AMP-elevating Agents Promote Cumulus Cell Survival and Hyaluronan Matrix Stability, Thereby Prolonging the Time of Mouse Oocyte Fertilizability.

    PubMed

    Di Giacomo, Monica; Camaioni, Antonella; Klinger, Francesca G; Bonfiglio, Rita; Salustri, Antonietta

    2016-02-19

    Cumulus cells sustain the development and fertilization of the mammalian oocyte. These cells are retained around the oocyte by a hyaluronan-rich extracellular matrix synthesized before ovulation, a process called cumulus cell-oocyte complex (COC) expansion. Hyaluronan release and dispersion of the cumulus cells progressively occur after ovulation, paralleling the decline of oocyte fertilization. We show here that, in mice, postovulatory changes of matrix are temporally correlated to cumulus cell death. Cumulus cell apoptosis and matrix disassembly also occurred in ovulated COCs cultured in vitro. COCs expanded in vitro with FSH or EGF underwent the same changes, whereas those expanded with 8-bromo-adenosine-3',5'-cyclic monophosphate (8-Br-cAMP) maintained integrity for a longer time. It is noteworthy that 8-Br-cAMP treatment was also effective on ovulated COCs cultured in vitro, prolonging the vitality of the cumulus cells and the stability of the matrix from a few hours to >2 days. Stimulation of endogenous adenylate cyclase with forskolin or inhibition of phosphodiesterase with rolipram produced similar effects. The treatment with selective cAMP analogues suggests that the effects of cAMP elevation are exerted through an EPAC-independent, PKA type II-dependent signaling pathway, probably acting at the post-transcriptional level. Finally, overnight culture of ovulated COCs with 8-Br-cAMP significantly counteracted the decrease of fertilization rate, doubling the number of fertilized oocytes compared with control conditions. In conclusion, these studies suggest that cAMP-elevating agents prevent cumulus cell senescence and allow them to continue to exert beneficial effects on oocyte and sperm, thereby extending in vitro the time frame of oocyte fertilizability. PMID:26694612

  15. Effect of different manganese concentrations during in vitro maturation of bovine oocytes on DNA integrity of cumulus cells and subsequent embryo development.

    PubMed

    Anchordoquy, J P; Anchordoquy, J M; Sirini, M A; Mattioli, G; Picco, S J; Furnus, C C

    2013-12-01

    Manganese (Mn) is a trace element present in forages and cereals, and its concentration depends on soil status. Manganese deficiency in cattle, goats and ewes not only impairs oestrous cycle but reduces calf birth weight. The achievement of the first oestrus is delayed, and more attempts are necessary to obtain a successful conception. This study was conducted to investigate the effect of the availability of supplemental Mn during IVM on DNA damage of cumulus cells and total glutathione (GSH) content in oocytes and cumulus cells. The effect of supplementary Mn during IVM on subsequent embryo development was also studied. The results reported here indicate (i) DNA damage in cumulus cells decreased with 0, 2, 5 and 6 ng/ml Mn supplementation during IVM (p < 0.05). (ii) Intracellular GSH-GSSG content increased (p < 0.01) with different Mn concentrations in oocytes and cumulus cells. Also, cumulus cell number per cumulus oocyte-complexes (COC) did not differ either before or after IVM. (iii) Addition of Mn to maturation medium resulted in similar cleavage rates (p > 0.05) at 0, 2, 5 and 6 ng/ml Mn. However, subsequent embryo development to blastocyst stage was significantly higher (p < 0.01) in oocytes matured with 5 and 6 ng/ml Mn. (iv) There was also an increase (p < 0.05) in mean cell number per blastocyst obtained from oocytes matured with 5 and 6 ng/ml respect to zero Mn (IVM alone) and 2 ng/ml Mn. This study provides evidence that optimal embryo development to the blastocyst stage was partially dependent on the presence of Mn during IVM. Moreover, the availability of Mn during oocyte maturation ensures 'normal' intracellular GSH content in COCs and protects DNA integrity of cumulus cells. PMID:23701210

  16. Goddard DEVELOP Students: Using NASA Remote Sensing Technology to Study the Chesapeake Bay Watershed

    NASA Technical Reports Server (NTRS)

    Moore, Rachel

    2011-01-01

    The DEVELOP National Program is an Earth Science research internship, operating under NASA s Applied Sciences Program. Each spring, summer, and fall, DEVELOP interns form teams to investigate Earth Science related issues. Since the Fall of 2003, Goddard Space Flight Center (GSFC) has been home to one of 10 national DEVELOP teams. In past terms, students completed a variety of projects related to the Applied Sciences Applications of National Priority, such as Public Health, Natural Disasters, Water Resources, and Ecological Forecasting. These projects have focused on areas all over the world, including the United States, Africa, and Asia. Recently, Goddard DEVELOP students have turned their attention to a local environment, the Chesapeake Bay Watershed. The Chesapeake Bay Watershed is a complex and diverse ecosystem, spanning approximately 64,000 square miles. The watershed encompasses parts of six states: Delaware, Maryland, New York, Pennsylvania, Virginia, and West Virginia, as well as the District of Columbia. The Bay itself is the biggest estuary in the United States, with over 100,000 tributaries feeding into it. The ratio of fresh water to salt water varies throughout the Bay, allowing for a variety of habitats. The Bay s wetlands, marshes, forests, reefs, and rivers support more than 3,600 plant and animal species, including birds, mammals, reptiles, amphibians, fish, and crabs. The Bay is also commercially significant. It is ranked third in the nation in fishery catch, and supplies approximately 500 million pounds of seafood annually. In addition to its abundant flora and fauna, the Chesapeake Bay watershed is home to approximately 16.6 million people, who live and work throughout the watershed, and who use its diverse resources for recreational purposes. Over the past several decades, the population throughout the watershed has increased rapidly, resulting in land use changes, and ultimately decreasing the health of the Chesapeake Bay Watershed. Over the

  17. Effects of Cloud on Goddard Lidar Observatory for Wind (GLOW) Performance and Analysis of Associated Errors

    NASA Astrophysics Data System (ADS)

    Bacha, Tulu

    The Goddard Lidar Observatory for Wind (GLOW), a mobile direct detection Doppler LIDAR based on molecular backscattering for measurement of wind in the troposphere and lower stratosphere region of atmosphere is operated and its errors characterized. It was operated at Howard University Beltsville Center for Climate Observation System (BCCOS) side by side with other operating instruments: the NASA/Langely Research Center Validation Lidar (VALIDAR), Leosphere WLS70, and other standard wind sensing instruments. The performance of Goddard Lidar Observatory for Wind (GLOW) is presented for various optical thicknesses of cloud conditions. It was also compared to VALIDAR under various conditions. These conditions include clear and cloudy sky regions. The performance degradation due to the presence of cirrus clouds is quantified by comparing the wind speed error to cloud thickness. The cloud thickness is quantified in terms of aerosol backscatter ratio (ASR) and cloud optical depth (COD). ASR and COD are determined from Howard University Raman Lidar (HURL) operating at the same station as GLOW. The wind speed error of GLOW was correlated with COD and aerosol backscatter ratio (ASR) which are determined from HURL data. The correlation related in a weak linear relationship. Finally, the wind speed measurements of GLOW were corrected using the quantitative relation from the correlation relations. Using ASR reduced the GLOW wind error from 19% to 8% in a thin cirrus cloud and from 58% to 28% in a relatively thick cloud. After correcting for cloud induced error, the remaining error is due to shot noise and atmospheric variability. Shot-noise error is the statistical random error of backscattered photons detected by photon multiplier tube (PMT) can only be minimized by averaging large number of data recorded. The atmospheric backscatter measured by GLOW along its line-of-sight direction is also used to analyze error due to atmospheric variability within the volume of measurement

  18. Computational Design of 2D materials for Energy Applications

    NASA Astrophysics Data System (ADS)

    Sun, Qiang

    2015-03-01

    Since the successful synthesis of graphene, tremendous efforts have been devoted to two-dimensional monolayers such as boron nitride (BN), silicene and MoS2. These 2D materials exhibit a large variety of physical and chemical properties with unprecedented applications. Here we report our recent studies of computational design of 2D materials for fuel cell applications which include hydrogen storage, CO2 capture, CO conversion and O2 reduction.

  19. Generating a 2D Representation of a Complex Data Structure

    NASA Technical Reports Server (NTRS)

    James, Mark

    2006-01-01

    A computer program, designed to assist in the development and debugging of other software, generates a two-dimensional (2D) representation of a possibly complex n-dimensional (where n is an integer >2) data structure or abstract rank-n object in that other software. The nature of the 2D representation is such that it can be displayed on a non-graphical output device and distributed by non-graphical means.

  20. Phylogenetic tree construction based on 2D graphical representation

    NASA Astrophysics Data System (ADS)

    Liao, Bo; Shan, Xinzhou; Zhu, Wen; Li, Renfa

    2006-04-01

    A new approach based on the two-dimensional (2D) graphical representation of the whole genome sequence [Bo Liao, Chem. Phys. Lett., 401(2005) 196.] is proposed to analyze the phylogenetic relationships of genomes. The evolutionary distances are obtained through measuring the differences among the 2D curves. The fuzzy theory is used to construct phylogenetic tree. The phylogenetic relationships of H5N1 avian influenza virus illustrate the utility of our approach.