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Sample records for 2p decay mechanism

  1. 2p-2p decay of {sup 8}C and isospin-allowed 2p decay of the isobaric-analog state in {sup 8}B

    SciTech Connect

    Charity, R. J.; Elson, J. M.; Manfredi, J.; Shane, R.; Sobotka, L. G.; Chajecki, Z.; Coupland, D.; Iwasaki, H.; Kilburn, M.; Lee, Jenny; Lynch, W. G.; Sanetullaev, A.; Tsang, M. B.; Winkelbauer, J.; Youngs, M.; Marley, S. T.; Shetty, D. V.; Wuosmaa, A. H.; Ghosh, T. K.

    2010-10-15

    {sup 8}C is found to decay to four protons and an {alpha} particle in two 2p emission steps. The correlations between the protons in the first step ({sup 8}C to {sup 6}Be) exhibit a significant enhancement in the region of the decay phase space where the two protons have small relative energy, a region sometimes called the diproton region. The decay of the isobaric analog of {sup 8}C in {sup 8}B is also found to decay by 2p emission. This is the first case of isospin-allowed 2p decay between isobaric analog states.

  2. Single, double, and triple Auger decay probabilities of C+(1 s 2 s22 p22 D ,2 P ) resonances

    NASA Astrophysics Data System (ADS)

    Zhou, Fuyang; Ma, Yulong; Qu, Yizhi

    2016-06-01

    Single, double, and triple Auger decay rates of C+(1 s 2 s22 p22 D ,2 P ) resonances were calculated in the framework of perturbation theory. The direct double Auger decay probabilities were calculated by using the approximate formulas according to the knockout and shakeoff mechanisms, in which the knockout mechanism was found to be dominant. Then the knockout mechanism was employed to investigate the complex triple Auger decay process, and the calculated rates have good agreement with the available experimental values.

  3. Observation of {chi}{sub bJ}(1P,2P) decays to light hadrons

    SciTech Connect

    Asner, D. M.; Edwards, K. W.; Reed, J.; Briere, R. A.; Tatishvili, G.; Vogel, H.; Onyisi, P. U. E.; Rosner, J. L.; Alexander, J. P.; Cassel, D. G.; Duboscq, J. E.; Ehrlich, R.; Fields, L.; Galik, R. S.; Gibbons, L.; Gray, R.; Gray, S. W.; Hartill, D. L.; Heltsley, B. K.; Hertz, D.

    2008-11-01

    Analyzing {upsilon}(nS) decays acquired with the CLEO detector operating at the CESR e{sup +}e{sup -} collider, we measure for the first time the product branching fractions B[{upsilon}(nS){yields}{gamma}{chi}{sub bJ}((n-1)P)]B[{chi}{sub bJ}(n-1)P){yields}X{sub i}] for n=2 and 3, where X{sub i} denotes, for each i, one of the 14 exclusive light-hadron final states for which we observe significant signals in both {chi}{sub bJ}(1P) and {chi}{sub bJ}(2P) decays. We also determine upper limits for the electric dipole (E1) transitions {upsilon}(3S){yields}{gamma}{chi}{sub bJ}(1P)

  4. Effect of entanglement on the decay dynamics of a pair of H(2p) atoms due to spontaneous emission

    SciTech Connect

    Tanabe, Takehiko; Odagiri, Takeshi; Nakano, Motoyoshi; Kumagai, Yoshiaki; Kitajima, Masashi; Kouchi, Noriyuki; Suzuki, Isao H.

    2010-10-15

    We have measured the coincidence time spectra of two Lyman-{alpha} photons emitted by a pair of H(2p) atoms in the photodissociation of H{sub 2} at the incident photon energy of 33.66 eV and at the hydrogen gas pressures of 0.40 and 0.02 Pa. The decay time constant at 0.02 Pa is approximately half the lifetime of a single H(2p) atom, 1.60 ns, while the decay time constant at 0.40 Pa is in agreement with the lifetime of a single H(2p) atom. It turns out that the decay faster than the lifetime of a single H(2p) atom originates from the entanglement in the pair of H(2p) atoms. We have demonstrated an effect of entanglement on atomic decay.

  5. An efficient query mechanism base on P2P networks

    NASA Astrophysics Data System (ADS)

    Wang, Xiaohua; Mu, Aiqin; Zhao, Defang

    2013-07-01

    How to implement the efficient query is the key problem deployed on P2P networks. This paper analyses the shortage of several query algorithm, and presents a new algorithm DDI, which means distributed searching with double indices. It discusses the popularity of documents and the linking status of the networks, and calculates the availability of the nodes in whole network, determines the route of the query process. It compares the items of time using, the quantity of requests and update information by the emulate experiments. Along with the rapid development of computer network technology, peer-to-peer (referred to as P2P) network research has gradually become mature, and it is widely used in different fields, some large P2P computing project has entered the implementation stage. At present, many more popular software systems such as Gnutella, Freenet, Napster are deployed based on P2P technology. How to achieve effective information query has become one of the key problems of P2P research.

  6. A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K+ Channels

    PubMed Central

    Schewe, Marcus; Nematian-Ardestani, Ehsan; Sun, Han; Musinszki, Marianne; Cordeiro, Sönke; Bucci, Giovanna; de Groot, Bert L.; Tucker, Stephen J.; Rapedius, Markus; Baukrowitz, Thomas

    2016-01-01

    Summary Two-pore domain (K2P) K+ channels are major regulators of excitability that endow cells with an outwardly rectifying background “leak” conductance. In some K2P channels, strong voltage-dependent activation has been observed, but the mechanism remains unresolved because they lack a canonical voltage-sensing domain. Here, we show voltage-dependent gating is common to most K2P channels and that this voltage sensitivity originates from the movement of three to four ions into the high electric field of an inactive selectivity filter. Overall, this ion-flux gating mechanism generates a one-way “check valve” within the filter because outward movement of K+ induces filter opening, whereas inward movement promotes inactivation. Furthermore, many physiological stimuli switch off this flux gating mode to convert K2P channels into a leak conductance. These findings provide insight into the functional plasticity of a K+-selective filter and also refine our understanding of K2P channels and the mechanisms by which ion channels can sense voltage. PMID:26919430

  7. Angle-resolved study of Ar 2p{sub 1/2,3/2}{sup -1} ns,d resonant Auger decay

    SciTech Connect

    Farhat, A.; Humphrey, M.; Langer, B.

    1997-04-01

    The Auger decay of core excited states in rare gases has been subject to rather intense investigation over a number of years due to its complex nature. The authors have measured the intensity distributions and angular distributions ({beta} parameters) for the Auger decay spectra following each of the 2p{sub 1/2,3/2} {r_arrow} 4s, 3d, 4d resonant excitations in argon. This report presents their result only for the angular distributions ({beta} parameters) of the 2p{sub 1/2}{sup {minus}1}4s resonance.

  8. Incentive Mechanism for P2P Content Sharing over Heterogenous Access Networks

    NASA Astrophysics Data System (ADS)

    Sato, Kenichiro; Hashimoto, Ryo; Yoshino, Makoto; Shinkuma, Ryoichi; Takahashi, Tatsuro

    In peer-to-peer (P2P) content sharing, users can share their content by contributing their own resources to one another. However, since there is no incentive for contributing contents or resources to others, users may attempt to obtain content without any contribution. To motivate users to contribute their resources to the service, incentive-rewarding mechanisms have been proposed. On the other hand, emerging wireless technologies, such as IEEE 802.11 wireless local area networks, beyond third generation (B3G) cellular networks and mobile WiMAX, provide high-speed Internet access for wireless users. Using these high-speed wireless access, wireless users can use P2P services and share their content with other wireless users and with fixed users. However, this diversification of access networks makes it difficult to appropriately assign rewards to each user according to their contributions. This is because the cost necessary for contribution is different in different access networks. In this paper, we propose a novel incentive-rewarding mechanism called EMOTIVER that can assign rewards to users appropriately. The proposed mechanism uses an external evaluator and interactive learning agents. We also investigate a way of appropriately controlling rewards based on the system service's quality and managing policy.

  9. Method of predicting mechanical properties of decayed wood

    DOEpatents

    Kelley, Stephen S.

    2003-07-15

    A method for determining the mechanical properties of decayed wood that has been exposed to wood decay microorganisms, comprising: a) illuminating a surface of decayed wood that has been exposed to wood decay microorganisms with wavelengths from visible and near infrared (VIS-NIR) spectra; b) analyzing the surface of the decayed wood using a spectrometric method, the method generating a first spectral data of wavelengths in VIS-NIR spectra region; and c) using a multivariate analysis to predict mechanical properties of decayed wood by comparing the first spectral data with a calibration model, the calibration model comprising a second spectrometric method of spectral data of wavelengths in VIS-NIR spectra obtained from a reference decay wood, the second spectral data being correlated with a known mechanical property analytical result obtained from the reference decayed wood.

  10. Decay processes of the core-excited states 1s2p3 for Be-like systems with Z=8-54

    NASA Astrophysics Data System (ADS)

    Sang, C. C.; Sun, Y.; Hu, F.

    2016-08-01

    On the basis of a fully relativistic multiconfiguration Dirac-Fock method, a systematic study has been carried out for the energies, radiative and non-radiative (Auger) decay processes of the core-excited states 1s2p3 for Be-like ions with Z=8-54. The energies and radiative transition rates are smoothly varying functions of Z. Auger rates do not change significantly with Z as the radiative rates do. Electron correlation effects on the energies and the radiative transition rates are investigated. Good agreement is found between our results and other theoretical data.

  11. Mechanisms of endonuclease-mediated mRNA decay.

    PubMed

    Schoenberg, Daniel R

    2011-01-01

    Endonuclease cleavage was one of the first identified mechanisms of mRNA decay but until recently it was thought to play a minor role to the better-known processes of deadenylation, decapping, and exonuclease-catalyzed decay. Most of the early examples of endonuclease decay came from studies of a particular mRNA whose turnover changed in response to hormone, cytokine, developmental, or nutritional stimuli. Only a few of these examples of endonuclease-mediated mRNA decay progressed to the point where the enzyme responsible for the initiating event was identified and studied in detail. The discovery of microRNAs and RISC-catalyzed endonuclease cleavage followed by the identification of PIN (pilT N-terminal) domains that impart endonuclease activity to a number of the proteins involved in mRNA decay has led to a resurgence of interest in endonuclease-mediated mRNA decay. PIN domains show no substrate selectivity and their involvement in a number of decay pathways highlights a recurring theme that the context in which an endonuclease function is a primary factor in determining whether any given mRNA will be targeted for decay by this or the default exonuclease-mediated decay processes.

  12. Mechanisms of the thermal decay of chlorpropham.

    PubMed

    Smith, Margaret J; Müller, Sandra; Sander, Wolfram; Bucher, Götz

    2013-02-15

    DFT calculations were performed on the thermal reactions of chlorpropham 1, a carbamate pesticide and plant growth regulator frequently used in the storage of potatoes. At the conditions normally used in applying 1 (injection of a methanolic solution of 1 into a hot air stream, T ≈ 500°C), both ester pyrolysis of 1 and a methanol-or water-catalysed isocyanate cleavage are expected to proceed rapidly (lifetime of 1 less than a second). In both reactions, the final reaction product will be toxic and carcinogenic m-chloroaniline 2. Matrix-isolation experiments indicate that 1 undergoes thermal decay at temperatures as low as 250°C. Up to temperatures of ca. 500°C, formation of m-chlorophenylisocyanate 4 and isopropanol was the predominant reaction observed, while formation of propene, CO(2), and m-chloroaniline 2 was the most important reaction channel at higher pyrolysis temperatures. m-Chlorophenyl carbamic acid 3 could not be observed. The results indicate that at lower temperatures, 1 decays exclusively via isocyanate cleavage of 1, provided that traces of catalytic water or other protic compounds are present. At higher temperatures, ester cleavage of 1 becomes competitive and outweighs the isocyanate cleavage by a factor of ca. 10:1. PMID:23295769

  13. Study of structures and dynamical decay mechanisms for multiquark systems

    NASA Astrophysics Data System (ADS)

    Liu, Xuewen; Ke, Hong-Wei; Liu, Xiang; Li, Xue-Qian

    2016-04-01

    The inner structures of the multiquark states are an interesting subject in hadron physics, generally they may be in tetraquark states which are composed of colored constituents, or in molecular states which are composed of two color singlets, or their mixtures. Therefore, the mechanisms which bind the constituents in a unique system and induce the multiquark states to decay would be different in those cases. In this work, using the quantum mechanics we analyze the dynamical mechanisms inducing decays of the tetraquarks where Y (4630 ) stands as an example for the study, we also comment on the molecular states without making numerical computations.

  14. The signature of initial production mechanisms in isotropic turbulence decay

    NASA Astrophysics Data System (ADS)

    Meldi, M.

    2016-03-01

    In the present work the quantification of the time-lasting effects of production mechanisms in homogeneous isotropic turbulence decay is addressed. The analysis is developed through the use of theoretical tools as well as numerical calculations based on the eddy damped quasinormal Markovian (EDQNM) model. In both cases a modified Lin equation is used, which accounts for production mechanisms as proposed by Meldi, Lejemble, and Sagaut ["On the emergence of non-classical decay regimes in multiscale/fractal generated isotropic turbulence," J. Fluid Mech. 756, 816-843 (2014)]. The approaches used show that an exponential decay law can be observed if the intensity of the forcing is strong enough to drive the turbulence dynamics, before a power-law decay is eventually attained. The EDQNM numerical results indicate that the exponential regime can persist for long evolution times, longer than the observation time in grid turbulence experiments. A rigorous investigation of the self-similar behavior of the pressure spectrum has been performed by a comprehensive comparison of EDQNM data with direct numerical simulation (DNS)/experiments in the literature. While DNS and free decay EDQNM simulations suggest the need of a very high Reλ threshold in order to observe a clear -7/3 slope of the pressure inertial range, experimental data and forced EDQNM calculations indicate a significantly lower value. This observation suggests that the time-lasting effects of production mechanisms, which cannot be excluded in experiments, play a role in the lack of general agreement with classical numerical approaches. These results reinforce the urge to evolve the numerical simulation state of the art towards the prediction of realistic physical states.

  15. Mechanism and regulation of the nonsense-mediated decay pathway

    PubMed Central

    Hug, Nele; Longman, Dasa; Cáceres, Javier F.

    2016-01-01

    The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs) but also regulates the abundance of a large number of cellular RNAs. The central role of NMD in the control of gene expression requires the existence of buffering mechanisms that tightly regulate the magnitude of this pathway. Here, we will focus on the mechanism of NMD with an emphasis on the role of RNA helicases in the transition from NMD complexes that recognize a PTC to those that promote mRNA decay. We will also review recent strategies aimed at uncovering novel trans-acting factors and their functional role in the NMD pathway. Finally, we will describe recent progress in the study of the physiological role of the NMD response. PMID:26773057

  16. Cosmological model with decaying vacuum energy from quantum mechanics

    NASA Astrophysics Data System (ADS)

    Szydłowski, Marek

    2015-06-01

    We construct the cosmological model to explain the cosmological constant problem. We built the extension of the standard cosmological model Λ CDM by consideration of decaying vacuum energy represented by the running cosmological term. From the principles of quantum mechanics one can find that in the long-term behavior survival probability of unstable states is a decreasing function of the cosmological time and has the inverse powerlike form. This implies that cosmological constant ρvac=Λ (t )=Λbare+α/t2 where Λbare and α are constants. We investigate the dynamics of this model using dynamical system methods due to a link to the Λ (H ) cosmologies. We have found the exact solution for the scale factor as well as the indicators of its variability like the deceleration parameter and the jerk. From the calculation of the jerk we obtain a simple test of the decaying vacuum in the Friedman-Robertson-Walker universe. Using astronomical data [SNIa, H (z ), CMB, BAO] we have estimated the model parameters and compared this model with the Λ CDM model. Our statistical results indicate that the decaying vacuum model is a little worse than the Λ CDM model. But the decaying vacuum cosmological model explains the small value of the cosmological constant today.

  17. Quantization in Classical Mechanics and Diffusion Mechanism of Alpha Decay, Cluster Radioactivity, Spontaneous Fission

    SciTech Connect

    Rusov, V. D.; Vlasenko, D. S.; Deliyergiyev, M. A.; Mavrodiev, S. Cht.

    2010-05-04

    Based on the Chetaev generalized theorem the Schredinger equation as the stability condition of trajectories in classical dynamics in the presence of dissipative forces is derived. In the framework of this approach the alternative model for unified description of alpha decay, spontaneous fission, cluster radioactivity and is developed. We show the possibility of the classical (without tunneling) description of radioactive decay of heavy nuclei, when the so called noise-induced transition or, in other words, the stochastic channel of radioactive decay conditioned by the Kramers diffusion mechanism is generated under certain conditions.Using the ENSDF nuclear data, we have found the parametrized solutions of the Kramers equation of the Langevin type by the Alexandrov dynamic auto-regularization method (REGN-Dubna program). These solutions describe with high-accuracy the dependences of half-life (the decay probability) of heavy radioactive nuclei on total kinetic energy of daughter decay products.Verification of the inverse problem solution in the framework of the universal Kramers description of alpha decay, spontaneous fission, cluster radioactivity, which based on the newest experimental data for alpha-decay of even-even superheavy nuclei (Z = 114, 116, 118), shows good coincidence of the experimental and theoretical dependences of half-life on alpha-decay energy.

  18. Quantization in Classical Mechanics and Diffusion Mechanism of Alpha Decay, Proton and Cluster Radioactivity, Spontaneous Fission

    SciTech Connect

    Rusov, V. D.; Vlasenko, D. S.; Deliyergiyev, M. A.; Mavrodiev, S. Cht.

    2010-01-01

    Based on the Chetaev generalized theorem the Schroedinger equation as the stability condition of trajectories in classical dynamics in the presence of dissipative forces is derived. In the framework of this approach the alternative model for unified description of alpha decay, spontaneous fission, cluster and proton radioactivity and is developed. We show the possibility of the classical (without tunneling) description of radioactive decay of heavy nuclei, when the so called noise-induced transition or, in other words, the stochastic channel of radioactive decay conditioned by the Kramers diffusion mechanism is generated under certain conditions.Using the ENSDF nuclear data, we have found the parametrized solutions of the Kramers equation of the Langevin type by the Alexandrov dynamic auto-regularization method (REGN-Dubna program). These solutions describe with high-accuracy the dependences of half-life (the decay probability) of heavy radioactive nuclei on total kinetic energy of daughter decay products.Verification of the inverse problem solution in the framework of the universal Kramers description of alpha decay, spontaneous fission, cluster and proton radioactivity, which based on the newest experimental data for alpha-decay of even-even superheavy nuclei (Z = 114, 116, 118), shows good coincidence of the experimental and theoretical dependences of half-life on alpha-decay energy.

  19. Decay mechanism of the 2004/05 Kuroshio large meander

    NASA Astrophysics Data System (ADS)

    Usui, Norihisa; Tsujino, Hiroyuki; Nakano, Hideyuki; Fujii, Yosuke; Kamachi, Masafumi

    2011-10-01

    The decay mechanism of the 2004/05 Kuroshio large meander (LM) is examined using a data assimilation/prediction system. Assimilation results reveal detailed variations of the Kuroshio path during the LM period. The Kuroshio takes the typical LM in September 2004 to January 2005. The LM then moves eastward and starts crossing the Izu Ridge (IR) in late January 2005. A minor path transition occurs again in June 2005. As a result, the meandering path straddles the IR, and subsequently the meander amplitude decreases rapidly, resulting in the disappearance of the LM. Prediction results suggest that these path transitions are caused by disturbances propagating along the Kuroshio. The assimilation results also indicate that the LM weakens after the first transition in late January 2005 and thus the transition triggers the subsequent LM decay. We propose three possible mechanisms for the weakening of the LM. (1) Extraction of high potential vorticity (PV) water from the LM by disturbances coming from the upstream of the Kuroshio. (2) Generation and propagation of the costal trapped waves, which are induced as a result of interaction of cold eddy of the LM and the IR, and extract potential energy from the LM. (3) Outflow of high-PV water of the LM to the downstream passing through a southern gate of the IR south of Hachijo-jima, which works after the meandering path straddles the IR. The mechanisms 2 and 3 are closely related to the existence of the IR, suggesting that the LM decay is prescribed by the IR.

  20. Decay of isotropic turbulence generated by a mechanically agitated grid.

    NASA Technical Reports Server (NTRS)

    Ling, S. C.; Wan, C. A.

    1972-01-01

    Experimental study of weak isotropic turbulence, created by a mechanically agitated grid, has indicated that in the absence of large linear-momentum wakes the energy of turbulence relaxes very quickly into a stable self-preserving structure, which, depending on the initial Reynolds number of turbulence, decays at different constant inverse powers of time. Both the longitudinal correlation coefficients and the corresponding spectral distributions, except for the difference in the parametric constants, are of the same functional type as those found previously for a passive grid.

  1. Comment on ''Effect of entanglement on the decay dynamics of a pair of H(2p) atoms due to spontaneous emission''

    SciTech Connect

    Sancho, Pedro; Plaja, Luis

    2011-06-15

    T. Tanabe et al. [Phys. Rev. A 82, 040101(R) (2010)] have experimentally demonstrated that the emission properties of unstable atoms in entangled and product states are different. The authors define an apparent decay time as a fitting parameter which falls below the lifetime of the single atom for entangled pairs. We argue that their results about coincidence time spectra are correct, but those concerning lifetimes cannot be considered conclusive because they assume the emission of photons by the two atoms to be independent processes, a doubtful hypothesis for entangled states. We suggest an improved evaluation of the lifetimes based on a rigorous approach, which demands some modifications of the experimental procedure.

  2. Relativistic evaluation of the two-photon decay of the metastable 1 s22 s 2 p 3P0 state in berylliumlike ions with an effective-potential model

    NASA Astrophysics Data System (ADS)

    Amaro, Pedro; Fratini, Filippo; Safari, Laleh; Machado, Jorge; Guerra, Mauro; Indelicato, Paul; Santos, José Paulo

    2016-03-01

    The two-photon 1 s22 s 2 p 3P0→1 s2s21S0 transition in berylliumlike ions is investigated theoretically within a fully relativistic framework and a second-order perturbation theory. We focus our analysis on how electron correlation, as well as the negative-energy spectrum, can affect the forbidden E 1 M 1 decay rate. For this purpose, we include the electronic correlation via an effective local potential and within a single-configuration-state model. Due to its experimental interest, evaluations of decay rates are performed for berylliumlike xenon and uranium. We find that the negative-energy contribution can be neglected at the present level of accuracy in the evaluation of the decay rate. On the other hand, if contributions of electronic correlation are not carefully taken into account, it may change the lifetime of the metastable state by up to 20%. By performing a fully relativistic j j -coupling calculation, we find a decrease of the decay rate by two orders of magnitude compared to nonrelativistic L S -coupling calculations, for the selected heavy ions.

  3. Mechanisms of charge transport in anisotype n-TiO{sub 2}/p-CdTe heterojunctions

    SciTech Connect

    Brus, V. V.; Ilashchuk, M. I.; Kovalyuk, Z. D.; Maryanchuk, P. D.; Ulyanytsky, K. S.; Gritsyuk, B. N.

    2011-08-15

    Surface-barrier anisotype n-TiO{sub 2}/p-CdTe heterojunctions are fabricated by depositing thin titanium-dioxide films on a freshly cleaved surface of single-crystalline cadmium-telluride wafers by reactive magnetron sputtering. It is established that the electric current through the heterojunctions under investigation is formed by generation-recombination processes in the space-charge region via a deep energy level and tunneling through the potential barrier. The depth and nature of the impurity centers involved in the charge transport are determined.

  4. Phonon mechanisms of nonlinear decay and dephasing of mesoscopic vibrational systems

    NASA Astrophysics Data System (ADS)

    Atalaya, Juan; Kenny, Thomas W.; Dykman, Mark I.

    2015-03-01

    The frequencies and the decay rates of mesoscopic oscillators depend on vibration amplitudes. Nonlinear decay has been seen recently in various nano- and micro-mechanical systems. Here we consider a microscopic mechanism of nonlinear decay, the nonlinear coupling of the vibrational mode of interest, for example, a flexural mode, to other vibrations. Typically, the modes of interest have low eigenfrequencies ω0. Their decay comes from the coupling to acoustic-phonon type vibrations with much higher frequency and density of states. Thus, nonlinear decay requires quartic anharmonic coupling or cubic anharmonicity in the higher order. We find the decay rate for the inverse lifetime of the involved phonons, which is determined by the internal nonlinearity and the boundary scattering, being either much larger or smaller than ω0. The results extend the thermo-elastic, Akhiezer, and Landau-Rumer decay theory to nonlinear decay of mesoscopic modes and make specific predictions on the temperature and frequency dependence of the decay rate for different types of systems. We show that nonlinear decay is invariably accompanied by dephasing. We also show that in nano-electro-mechanical systems the decay rate can be electrostatically controlled.

  5. Configuration-interaction-induced dynamic spin polarization of the Ar*(2p{sub 1/2,3/2}{sup -1}4s{sub 1/2}){sub J=1} resonant Auger decay

    SciTech Connect

    Lohmann, B.; Langer, B.; Snell, G.; Canton, S.; Berrah, N.; Kleiman, U.; Becker, U.; Martins, M.

    2005-02-01

    Spin-resolved measurements of the Ar{sup *}(2p{sub 1/2,3/2}{sup -1}4s{sub 1/2}){sub J=1} resonantly excited L{sub 2,3}M{sub 2,3}M{sub 2,3} Auger decay have been performed. The low resolution Auger spectrum, which due to cancellation between different multiplet components should exhibit virtually zero dynamic spin polarization, reveals an unexpected nonvanishing polarization effect. Calculations within a relativistic distorted wave approximation explain this effect as configuration-interaction (CI) induced. The CI generates experimentally unresolved fine structure components with low and high total angular momentum, giving rise to asymmetric cases where the high J part of certain multiplets is suppressed by internal selection rules for diagram lines. In this case, only the low J components survive with no partner for spin-polarization cancellation.

  6. Shell model nuclear matrix elements for competing mechanisms contributing to double beta decay

    SciTech Connect

    Horoi, Mihai

    2013-12-30

    Recent progress in the shell model approach to the nuclear matrix elements for the double beta decay process are presented. This includes nuclear matrix elements for competing mechanisms to neutrionless double beta decay, a comparison between closure and non-closure approximation for {sup 48}Ca, and an updated shell model analysis of nuclear matrix elements for the double beta decay of {sup 136}Xe.

  7. Resonance and decay phenomena lead to quantum mechanical time asymmetry

    NASA Astrophysics Data System (ADS)

    Bohm, A.; Bui, H. V.

    2013-04-01

    The states (Schrödinger picture) and observables (Heisenberg picture) in the standard quantum theory evolve symmetrically in time, given by the unitary group with time extending over -∞ < t < +∞. This time evolution is a mathematical consequence of the Hilbert space boundary condition for the dynamical differential equations. However, this unitary group evolution violates causality. Moreover, it does not solve an old puzzle of Wigner: How does one describe excited states of atoms which decay exponentially, and how is their lifetime τ related to the Lorentzian width Γ? These question can be answered if one replaces the Hilbert space boundary condition by new, Hardy space boundary conditions. These Hardy space boundary conditions allow for a distinction between states (prepared by a preparation apparatus) and observables (detected by a registration apparatus). The new Hardy space quantum theory is time asymmetric, i.e, the time evolution is given by the semigroup with t0 <= t < +∞, which predicts a finite "beginning of time" t0, where t0 is the ensemble of time at which each individual system has been prepared. The Hardy space axiom also leads to the new prediction: the width Γ and the lifetime τ are exactly related by τ = hslash/Γ.

  8. Nonradiative decay mechanisms of complexed indole derivatives studied by time-resolved fluorescence

    NASA Astrophysics Data System (ADS)

    Schauerte, Joseph A.; Gafni, Ari

    1990-05-01

    Ground and excited state characteristics of substituted indole derivatives reveal a sensitivity of indoles' electronic properties to the nature and location of substitutions on the indole ring. These substitutions affect both the nature of the excited electronic state and the susceptibility of this state to non-radiative decay processes. A number of mechanisms that deactivate the excited state have been identified including intersystem crossing, electron photoejection into polar solvents, and >N-H dissociation in polar solvents (see Glasser & Lami,1986) . While the >N-H group has been implicated in non-radiative decay processes in polar solvents, covalent substitutions elsewhere on the indole molecule may modulate the importance of this site in non-radiative decay mechanisms or alternatively these substitutions may introduce new deactivation mechanisms. Additionally, complexes formed between indole derivatives and β-cyclodextrin cavities show different sensitivity to excited state deactivation mechanisms dependent upon the location and nature of the covalent substitution. We have investigated the excited states of some indole derivatives substituted at position 5, para to the >N-H group on the benzyl ring, to determine the effect of such covalent substitutions on the fluorescence emission characteristics of the indole ring as well as on its susceptibility to alternate excited state decay mechanisms.

  9. Induction of intranuclear membranes by overproduction of Opi1p and Scs2p, regulators for yeast phospholipid biosynthesis, suggests a mechanism for Opi1p nuclear translocation.

    PubMed

    Masuda, Miki; Oshima, Ayaka; Noguchi, Tetsuko; Kagiwada, Satoshi

    2016-03-01

    In the yeast Saccharomyces cerevisiae, the expression of phospholipid biosynthetic genes is suppressed by the Opi1p negative regulator. Opi1p enters into the nucleoplasm from the nuclear membrane to suppress the gene expression under repressing conditions. The binding of Opi1p to the nuclear membrane requires an integral membrane protein, Scs2p and phosphatidic acid (PA). Although it is demonstrated that the association of Opi1p with membranes is affected by PA levels, how Opi1p dissociates from Scs2p is unknown. Here, we found that fluorescently labelled Opi1p accumulated on a perinuclear region in an Scs2p-dependent manner. Electron microscopic analyses indicated that the perinuclear region consists of intranuclear membranes, which may be formed by the invagination of the nuclear membrane due to the accumulation of Opi1p and Scs2p in a restricted area. As expected, localization of Opi1p and Scs2p in the intranuclear membranes was detected by immunoelectron microscopy. Biochemical analysis showed that Opi1p recovered in the membrane fraction was detergent insoluble while Scs2p was soluble, implying that Opi1p behaves differently from Scs2p in the fraction. We hypothesize that Opi1p dissociates from Scs2p after targeting to the nuclear membrane, making it possible to be released from the membrane quickly when PA levels decrease. PMID:26590299

  10. Chlorophyll-quinone photochemistry in liposomes: mechanisms of radical formation and decay

    SciTech Connect

    Hurley, J.K.; Tollin, G.

    1980-01-01

    Laser flash photolysis has been used to investigate the mechanism of formation and decay of the radical species generated by light induced electron transfer from chlorophyll a triplet to quinone in egg phosphatidyl choline bilayer vesicles. Chlorophyll triplet quenching by quinone is controlled by diffusion occurring within the bilayer membrane and reflects bilayer viscosity. Radical formation via separation of the intermediate ion pair is also inhibited by increased bilayer viscosity. Cooperativity is observed in this process due to an enhancement of radical separation by electron transfer from semiquinone anion radical to a neighboring quinone molecule. Two modes of radical decay are observed, a rapid recombination occurring within the bilayer and a much slower recombination occurring across the bilayer. The slow decay is only observed with quinones which are not tightly anchored into the bilayer, and is probably the result of electron transfer from semiquinone anion radical formed within the bilayer to a quinone molecule residing at the bilayer-water interface. With benzoquinone, approximately 60% of the radical decay occurs via the slow mode. Triplet to radical conversion efficiencies in the bilayer systems are comparable to those obtained in fluid solution (approx. 60%). However, radical recombination, at least for the slow decay mechanism, is considerably retarded.

  11. Influence of fluoride additions on biological and mechanical properties of Na2O-CaO-SiO2-P2O5 glass-ceramics.

    PubMed

    Li, H C; Wang, D G; Hu, J H; Chen, C Z

    2014-02-01

    Two series of Na2O-CaO-SiO2-P2O5 glass-ceramics doped with NH4HF2 (G-NH4HF2) or CaF2 (G-CaF2) have been prepared by sol-gel method. The glass-ceramic phase composition and morphology were characterized by X-ray diffraction (XRD) and scanning electron microscopy coupled with energy dispersive spectroscopy (SEM-EDS). The mechanical properties and thermal expansion coefficient were measured by a microhardness tester, an electronic tensile machine and a thermal expansion coefficient tester. The structure difference between these two glass-ceramics was investigated by Fourier transform infrared spectroscopy (FTIR), and the in vitro bioactivity of the glass-ceramics was determined by in vitro simulated body fluid (SBF) immersion test. The hemolysis test, in vitro cytotoxicity test, systemic toxicity test and the implanted experiment in animals were used to evaluate the biocompatibility of the glass-ceramics. The mechanical properties of sample G-NH4HF2 are lower than that of sample G-CaF2, and the bioactivity of sample G-NH4HF2 is better than that of sample G-CaF2. The thermal expansion coefficients of these two glass-ceramics are all closer to that of Ti6Al4V. After 7 days of SBF immersion, apatites were induced on glass-ceramic surface, indicating that the glass-ceramics have bioactivity. The hemolysis test, in vitro cytotoxicity test and systemic toxicity test demonstrate that the glass-ceramics do not cause hemolysis reaction, and have no toxicity to cell and living animal. The implanted experiment in animals shows that bone tissue can form a good osseointegration with the implant after implantation for two months, indicating that the glass-ceramics are safe to serve as implants.

  12. T(T,4He)2n and 3He(3He,4He)2p Reactions and the Energy Dependence of Their Mechanisms

    NASA Astrophysics Data System (ADS)

    Bacher, Andrew; McNabb, Dennis; Brune, Carl; Sayre, Dan; Hale, Gerry; Frenje, Johan; Gatu Johnson, Maria

    2015-10-01

    We have studied the T(T,alpha)2n reaction because it is the charge symmetric analog to the 3He(3He,alpha)2p reaction which completes the most direct mode of the p-p chain in stellar interiors. These reactions lead to three-body final states whose energy spectrum shapes are dominated by the strong nucleon-alpha interaction and the weaker nucleon-nucleon interaction. These experiments were done at OMEGA at the University of Rochester and at the NIF at Lawrence Livermore Lab. We will focus on two features: (1) the excitation energy dependence of the reaction mechanism and (2) the center-of-mass energy dependence of the reaction mechanism. At stellar energies (OMEGA and the NIF) we find that the shape of the neutron spectrum peaks in the middle. The n-alpha 1/2-excited state is about two times stronger than the n-alpha 3/2-ground state. For the 3He+3He reaction (at CalTech), the proton spectrum peaks at the high end. The p-alpha 3/2-state is about two times stronger than the 1/2-state. This difference in the spectrum shape is explained by theoretical models which include the interference between the two identical fermions in the final state. At CalTech we have angular distributions of the 3He+3He reaction from 2 MeV to 18 MeV. We see the p-wave strength increasing.

  13. Influence of fluoride additions on biological and mechanical properties of Na2O-CaO-SiO2-P2O5 glass-ceramics.

    PubMed

    Li, H C; Wang, D G; Hu, J H; Chen, C Z

    2014-02-01

    Two series of Na2O-CaO-SiO2-P2O5 glass-ceramics doped with NH4HF2 (G-NH4HF2) or CaF2 (G-CaF2) have been prepared by sol-gel method. The glass-ceramic phase composition and morphology were characterized by X-ray diffraction (XRD) and scanning electron microscopy coupled with energy dispersive spectroscopy (SEM-EDS). The mechanical properties and thermal expansion coefficient were measured by a microhardness tester, an electronic tensile machine and a thermal expansion coefficient tester. The structure difference between these two glass-ceramics was investigated by Fourier transform infrared spectroscopy (FTIR), and the in vitro bioactivity of the glass-ceramics was determined by in vitro simulated body fluid (SBF) immersion test. The hemolysis test, in vitro cytotoxicity test, systemic toxicity test and the implanted experiment in animals were used to evaluate the biocompatibility of the glass-ceramics. The mechanical properties of sample G-NH4HF2 are lower than that of sample G-CaF2, and the bioactivity of sample G-NH4HF2 is better than that of sample G-CaF2. The thermal expansion coefficients of these two glass-ceramics are all closer to that of Ti6Al4V. After 7 days of SBF immersion, apatites were induced on glass-ceramic surface, indicating that the glass-ceramics have bioactivity. The hemolysis test, in vitro cytotoxicity test and systemic toxicity test demonstrate that the glass-ceramics do not cause hemolysis reaction, and have no toxicity to cell and living animal. The implanted experiment in animals shows that bone tissue can form a good osseointegration with the implant after implantation for two months, indicating that the glass-ceramics are safe to serve as implants. PMID:24411365

  14. Mechanical properties and histological evaluation of sintered beta-Ca2P2O7 with Na4P2O7.10H2O addition.

    PubMed

    Lin, F H; Lin, C C; Lu, C M; Liu, H C; Sun, J S; Wang, C Y

    1995-07-01

    The ultimate goal of implantation of biomaterials in the skeleton is to reach full integration of the non-living implant with the living bone. The biomaterial can be used much as a bone graft, resorbing or dissolving as bone growth occurs, and the end result is a new remoulded bone. Calcium pyrophosphate, Ca2P2O7, is one of the intermediate products of bone mineralization. beta-Dicalcium pyrophosphate (beta-DCP) doped with certain amounts of Na4P2O7.10H2O was prepared as the developed material. Na4P2O7.10H2O was used as a liquid-phase additive to improve the sintering process and promote physiological bioresorbability. Compressive strength and four-point bending strength were measured by the Bionix test system 858. The mechanical strength of the sintered beta-DCP increased with the addition of Na4P2O7.10H2O up to 5 wt%, but thereafter decreased. The microstructure and crystal structure were analysed by the techniques of SEM, EPMA, TEM and XRD. The relationship between the mechanical strength of the sintered bioceramics and the Na4P2O7.10H2O dopant was examined in terms of the presence of NaCa(PO3)3, grain growth and abnormal grain coalescence while the dopant increased. Preliminary in vivo evaluation was studied by rabbit femur condyle implantation. There was no inflammation or any toxic sign during the experimental period. The histological section of intraosseous implantation revealed that the new bone deposited directly on the surface of the material in the fourth week after operation. The implant gradually decreased in volume and was replaced by the surrounding regenerated bone in the rabbit condyle in vivo environment. The results led us to conclude that the developed material has great potential as a biodegradable bone substitute.

  15. 2p radioactivity studied by tracking technique

    SciTech Connect

    Mukha, Ivan

    2010-06-01

    The recent advance in experimental studies of short-lived exotic nuclei beyond the proton drip line is presented. In particular, in-flight decays of proton-unbound nuclei with picosecond lifetimes can be probed by a novel technique which tracks all decay products precisely, and the decay vertices as well as the angular correlations of the fragments are deduced from the measured trajectories. The corresponding pioneering experiment which identified a previously-unknown isotope {sup 19}Mg and its two-proton (2p) radioactivity as well as studied the reference 2p decay of the known isotope {sup 16}Ne is described. Systematic studies of other 2p precursors beyond the proton drip line are foreseen with this powerful technique whose sensitivity is larger by factor of 30 in comparison with a conventional invariant-mass method. The 2p radioactivity candidates {sup 30}Ar, {sup 34}Ca and {sup 26}S are discussed. Information about the respective one-proton unbound nuclei can be obtained with this technique by evaluating proton-heavy-fragment correlations. Systematic studies of nuclei beyond the proton drip line, e.g., the well-known proton resonances above the 'waiting points' in the astrophysical rp-process, {sup 69}Br and {sup 73}Br are feasible.

  16. Disentangling the various Mechanisms of neutrinoless double beta decay to extract the neutrino mass

    SciTech Connect

    Vergados, J. D.

    2011-12-16

    It is well known that there exist many mechanisms that may contribute to neutrinoless double beta decay. By exploiting the fact that the associated nuclear matrix elements are target dependent we show that, given definite experimental results on a sufficient number of targets, one can determine or sufficiently constrain all lepton violating parameters including the mass term. As a specific example we show that, given the observation of the 0{nu}{beta}{beta}-decay in three different nuclei, e.g. {sup 76}Ge, {sup 100}Mo and {sup 130}Te, and assuming just three active lepton number violating parameters, e.g. light and heavy neutrino mass mechanisms in left handed currents as well as R-parity breaking SUSY mechanism, one may determine all lepton violating parameters, provided that they are relatively real.

  17. Barr-Freire-Zee mechanism for the hydrogen-ionizing decaying neutrino dark matter

    NASA Astrophysics Data System (ADS)

    Tommasini, Daniele

    1992-12-01

    We consider the scenario of the hydrogen-ionizing decaying neutrino dark matter, advocated by Sciama to solve several ionization problems in astrophysics and cosmology. We show that dangerously large neutrino oscillations are expected in general in the particle physics models introduced to provide the required neutrino masses and dark matter decay lifetime. However, the implementation of a mechanism recently discovered by Barr, Freire and Zee, allows to realize this scenario free of large neutrino oscillations. Furthermore, in this case a mass scale for the light neutrinos, which can be naturally the MSW solar neutrino scale ~ 10-3 eV, is automatically associated to the value ~ 1023 s of the dark matter decay lifetime, needed to solve the ionization problems. A realization of the mechanism in the supersymmetric standard model with broken R-parity is then considered as an example. In that case, the heavy neutrino providing the dark matter is made up mainly by the standard muon neutrino νμ.

  18. Auger decay mechanism in photon-stimulated desorption of ions from surfaces

    SciTech Connect

    Parks, C.C.

    1983-11-01

    Photon-stimulated desorption (PSD) of positive ions was studied with synchrotron radiation using an angle-integrating time-of-flight mass spectrometer. Ion yields as functions of photon energy near core levels were measured from condensed gases, alkali fluorides, and other alkali and alkaline earth halides. These results are compared to bulk photoabsorption measurements with emphasis on understanding fundamental desorption mechanisms. The applicability of the Auger decay mechanism, in which ion desorption is strictly proportional to surface absorption, is discussed in detail. The Auger decay model is developed in detail to describe Na/sup +/ and F/sup +/ desorption from NaF following Na(1s) excitation. The major decay pathways of the Na(1s) hole leading to desorption are described and equations for the energetics of ion desorption are developed. Ion desorption spectra of H/sup +/, Li/sup +/, and F/sup +/ are compared to bulk photoabsorption near the F(2s) and Li(1s) edges of LiF. A strong photon beam exposure dependence of ion yields from alkali fluorides is revealed, which may indicate the predominance of metal ion desorption from defect sites. The large role of indirect mechanisms in ion desorption condensed N/sub 2/-O/sub 2/ multilayers is demonstrated and discussed. Ion desorption spectra from several alkali halides and alkaline earth halides are compared to bulk photoabsorption spectra. Relative ion yields from BaF/sub 2/ and a series of alkali halides are discussed in terms of desorption mechanisms.

  19. Study of decay mechanisms in B--->Lambdac+ppi- decays and observation of low-mass structure in the Lambdac+p system.

    PubMed

    Gabyshev, N; Abe, K; Abe, K; Adachi, I; Aihara, H; Asano, Y; Aulchenko, V; Aushev, T; Bakich, A M; Bitenc, U; Bizjak, I; Blyth, S; Bondar, A; Bozek, A; Bracko, M; Brodzicka, J; Browder, T E; Chang, P; Chao, Y; Chen, A; Chen, W T; Cheon, B G; Chistov, R; Choi, S-K; Choi, Y; Chuvikov, A; Cole, S; Dalseno, J; Danilov, M; Dash, M; Drutskoy, A; Eidelman, S; Enari, Y; Fratina, S; Gershon, T; Gokhroo, G; Golob, B; Gorisek, A; Hara, T; Hayashii, H; Hazumi, M; Hokuue, T; Hoshi, Y; Hou, S; Hou, W-S; Hsiung, Y B; Iijima, T; Imoto, A; Inami, K; Ishikawa, A; Itoh, R; Iwasaki, M; Iwasaki, Y; Kang, J H; Kang, J S; Kataoka, S U; Katayama, N; Kawai, H; Kawasaki, T; Khan, H R; Kichimi, H; Kim, H J; Kim, H O; Kim, S K; Kim, S M; Kinoshita, K; Korpar, S; Krokovny, P; Kumar, S; Kuo, C C; Kuzmin, A; Kwon, Y-J; Lange, J S; Leder, G; Lesiak, T; Lin, S-W; Mandl, F; Matsumoto, T; Mikami, Y; Mitaroff, W; Miyake, H; Miyata, H; Mizuk, R; Nagamine, T; Nagasaka, Y; Nakano, E; Nakao, M; Nakazawa, H; Natkaniec, Z; Nishida, S; Nitoh, O; Ogawa, S; Ohshima, T; Okabe, T; Okuno, S; Olsen, S L; Onuki, Y; Ozaki, H; Palka, H; Park, C W; Park, H; Parslow, N; Peak, L S; Pestotnik, R; Piilonen, L E; Rozanska, M; Sagawa, H; Sakai, Y; Sato, N; Schietinger, T; Schneider, O; Schwartz, A J; Senyo, K; Seuster, R; Sevior, M E; Shibuya, H; Sidorov, V; Singh, J B; Somov, A; Stamen, R; Stanic, S; Staric, M; Sumiyoshi, T; Suzuki, S Y; Tajima, O; Takasaki, F; Tamai, K; Tamura, N; Tanaka, M; Teramoto, Y; Tian, X C; Tsuboyama, T; Tsukamoto, T; Uehara, S; Uglov, T; Ueno, K; Uno, S; Urquijo, P; Varner, G; Varvell, K E; Villa, S; Wang, C H; Wang, M-Z; Xie, Q L; Yabsley, B D; Yamaguchi, A; Yamamoto, H; Yamashita, Y; Yamauchi, M; Yang, Heyoung; Zhang, C C; Zhang, J; Zhang, L M; Zhang, Z P; Zhilich, V; Zontar, D

    2006-12-15

    Using a sample of 152 x 10(6) BB pairs accumulated with the Belle detector at the KEKB e+e- collider, we study the decay mechanism of three-body charmed decay B- --> Lambdac+ ppi-. The intermediate two-body decay B--->Sigmac (2455)0 p is observed for the first time with a branching fraction of (3.7 +/- 0.7 +/- 0.4 +/- 1.0) x 10(-5) and a statistical significance of 8.4sigma. We also observe a low-mass enhancement in the (Lambdac+p) system, which can be parametrized as a Breit-Wigner function with a mass of (3.35(-0.02)(+0.01) +/-0.02) GeV/c2 and a width of (0.07(-0.03)(+0.04) +/-0.04) GeV/c2. We measure its branching fraction to be (3.9(-0.7)(+0.8) +/- 0.4 +/- 1.0) x 10(-5) with a statistical significance of 6.2sigma. The errors are statistical, systematic, and that of the Lambdac+-->pK- pi+ decay branching fraction. PMID:17280269

  20. A biological mechanism for Bayesian feature selection: Weight decay and raising the LASSO.

    PubMed

    Connor, Patrick; Hollensen, Paul; Krigolson, Olav; Trappenberg, Thomas

    2015-07-01

    Biological systems are capable of learning that certain stimuli are valuable while ignoring the many that are not, and thus perform feature selection. In machine learning, one effective feature selection approach is the least absolute shrinkage and selection operator (LASSO) form of regularization, which is equivalent to assuming a Laplacian prior distribution on the parameters. We review how such Bayesian priors can be implemented in gradient descent as a form of weight decay, which is a biologically plausible mechanism for Bayesian feature selection. In particular, we describe a new prior that offsets or "raises" the Laplacian prior distribution. We evaluate this alongside the Gaussian and Cauchy priors in gradient descent using a generic regression task where there are few relevant and many irrelevant features. We find that raising the Laplacian leads to less prediction error because it is a better model of the underlying distribution. We also consider two biologically relevant online learning tasks, one synthetic and one modeled after the perceptual expertise task of Krigolson et al. (2009). Here, raising the Laplacian prior avoids the fast erosion of relevant parameters over the period following training because it only allows small weights to decay. This better matches the limited loss of association seen between days in the human data of the perceptual expertise task. Raising the Laplacian prior thus results in a biologically plausible form of Bayesian feature selection that is effective in biologically relevant contexts. PMID:25897512

  1. Inclusive J/{psi} production in {Upsilon} decay via color-singlet mechanism

    SciTech Connect

    He Zhiguo; Wang Jianxiong

    2010-03-01

    In this work, we have calculated the tree level color-singlet contribution to the inclusive J/{psi} production in {Upsilon} decay of the {alpha}{sub s}{sup 5} order QCD process {Upsilon}{yields}J/{psi}+ccg and {alpha}{sup 2{alpha}}{sub s}{sup 2} order QED processes {Upsilon}{yields}{gamma}*{yields}J/{psi}+cc and {Upsilon}{yields}J/{psi}+gg. It is found that the contribution of the QED processes is comparable with that of the QCD process and the numerical results of the QCD process alone are about an order of magnitude smaller than the previous theoretical predictions. Our prediction in total is 4.2x10{sup -5} which is about an order of magnitude smaller than the recent CLEO measurement on the branching fraction B({Upsilon}{yields}J/{psi}+X). It indicates that the J/{psi} production mechanism in {Upsilon} decay is not well understood and further theoretical work and experimental analysis are still necessary.

  2. Mechanism of decay of the cry1Aa mRNA in Bacillus subtilis.

    PubMed Central

    Vázquez-Cruz, C; Olmedo-Alvarez, G

    1997-01-01

    We undertook the study of the decay process of the cry1Aa mRNA of Bacillus thuringiensis expressed in B. subtilis. The cry1Aa transcript is a 3.7-kb mRNA expressed during sporulation whose transcriptional control has previously been studied in both B. subtilis and B. thuringiensis. We found that the cry1Aa mRNA has a half-life of around 9 min and that its decay occurs through endoribonucleolytic cleavages which result in three groups of high-molecular-weight mRNA intermediates ranging in size from 2.7 to 0.5 kb. A comparative study carried out with Escherichia coli showed a similar pattern of degradation intermediates. Primer extension analysis carried out on RNA from B. subtilis revealed that most cleavages occur within two regions located toward the 5' and 3' ends of the mRNA. The most prominent processing site observed for the cry1Aa mRNA isolated from B. subtilis is only two bases away from that occurring on RNA isolated from E. coli. Most cleavage sites occur at seemingly single-stranded RNA segments rich in A and U nucleotides, suggesting that a common and conserved mechanism may process the cry1Aa mRNA. PMID:9335281

  3. Evolution of novel wood decay mechanisms in Agaricales revealed by the genome sequences of Fistulina hepatica and Cylindrobasidium torrendii.

    PubMed

    Floudas, Dimitrios; Held, Benjamin W; Riley, Robert; Nagy, Laszlo G; Koehler, Gage; Ransdell, Anthony S; Younus, Hina; Chow, Julianna; Chiniquy, Jennifer; Lipzen, Anna; Tritt, Andrew; Sun, Hui; Haridas, Sajeet; LaButti, Kurt; Ohm, Robin A; Kües, Ursula; Blanchette, Robert A; Grigoriev, Igor V; Minto, Robert E; Hibbett, David S

    2015-03-01

    Wood decay mechanisms in Agaricomycotina have been traditionally separated in two categories termed white and brown rot. Recently the accuracy of such a dichotomy has been questioned. Here, we present the genome sequences of the white-rot fungus Cylindrobasidium torrendii and the brown-rot fungus Fistulina hepatica both members of Agaricales, combining comparative genomics and wood decay experiments. C. torrendii is closely related to the white-rot root pathogen Armillaria mellea, while F. hepatica is related to Schizophyllum commune, which has been reported to cause white rot. Our results suggest that C. torrendii and S. commune are intermediate between white-rot and brown-rot fungi, but at the same time they show characteristics of decay that resembles soft rot. Both species cause weak wood decay and degrade all wood components but leave the middle lamella intact. Their gene content related to lignin degradation is reduced, similar to brown-rot fungi, but both have maintained a rich array of genes related to carbohydrate degradation, similar to white-rot fungi. These characteristics appear to have evolved from white-rot ancestors with stronger ligninolytic ability. F. hepatica shows characteristics of brown rot both in terms of wood decay genes found in its genome and the decay that it causes. However, genes related to cellulose degradation are still present, which is a plesiomorphic characteristic shared with its white-rot ancestors. Four wood degradation-related genes, homologs of which are frequently lost in brown-rot fungi, show signs of pseudogenization in the genome of F. hepatica. These results suggest that transition toward a brown-rot lifestyle could be an ongoing process in F. hepatica. Our results reinforce the idea that wood decay mechanisms are more diverse than initially thought and that the dichotomous separation of wood decay mechanisms in Agaricomycotina into white rot and brown rot should be revisited.

  4. Evolution of novel wood decay mechanisms in Agaricales revealed by the genome sequences of Fistulina hepatica and Cylindrobasidium torrendii

    PubMed Central

    Floudas, Dimitrios; Held, Benjamin W.; Riley, Robert; Nagy, Laszlo G.; Koehler, Gage; Ransdell, Anthony S.; Younus, Hina; Chow, Julianna; Chiniquy, Jennifer; Lipzen, Anna; Tritt, Andrew; Sun, Hui; Haridas, Sajeet; LaButti, Kurt; Ohm, Robin A.; Kües, Ursula; Blanchette, Robert A.; Grigoriev, Igor V.; Minto, Robert E.; Hibbett, David S.

    2015-01-01

    Wood decay mechanisms in Agaricomycotina have been traditionally separated in two categories termed white and brown rot. Recently the accuracy of such a dichotomy has been questioned. Here, we present the genome sequences of the white rot fungus Cylindrobasidium torrendii and the brown rot fungus Fistulina hepatica both members of Agaricales, combining comparative genomics and wood decay experiments. Cylindrobasidium torrendii is closely related to the white-rot root pathogen Armillaria mellea, while F. hepatica is related to Schizophyllum commune, which has been reported to cause white rot. Our results suggest that C. torrendii and S. commune are intermediate between white-rot and brown-rot fungi, but at the same time they show characteristics of decay that resembles soft rot. Both species cause weak wood decay and degrade all wood components but leave the middle lamella intact. Their gene content related to lignin degradation is reduced, similar to brown-rot fungi, but both have maintained a rich array of genes related to carbohydrate degradation, similar to white-rot fungi. These characteristics appear to have evolved from white-rot ancestors with stronger ligninolytic ability. Fistulina hepatica shows characteristics of brown rot both in terms of wood decay genes found in its genome and the decay that it causes. However, genes related to cellulose degradation are still present, which is a plesiomorphic characteristic shared with its white-rot ancestors. Four wood degradation-related genes, homologs of which are frequently lost in brown-rot fungi, show signs of pseudogenization in the genome of F. hepatica. These results suggest that transition towards a brown rot lifestyle could be an ongoing process in F. hepatica. Our results reinforce the idea that wood decay mechanisms are more diverse than initially thought and that the dichotomous separation of wood decay mechanisms in Agaricomycotina into white rot and brown rot should be revisited. PMID:25683379

  5. Significance of decay mechanism into continuum in dynamical Wannier-Stark ladder

    SciTech Connect

    Nemoto, Yuya; Maeshima, Nobuya; Hino, Ken-ichi

    2013-12-04

    We examine the resonance structure of photodressed electron states of laser-driven Wannier-Stark ladder, namely, dynamic Wannier-Stark ladder, in terms of the excess density of states (DOS) closely related to a lifetime of the state of concern. It is revealed that the resonance structure in the strong laser-field region shows clear dependence on the ratio, η, of a Bloch-frequency to a laser frequency. As the laser strength increases, for η = 1, the excess DOS becomes involved with a lot of newly-growing resonance peaks. This result would be understood from the viewpoint of a Fano-like decay-mechanism caused by a multichannel continuum effect, in marked contrast to the cases of larger η’s; for η = 3, the excess DOS just is found to show a pronounced red-shift of a single dominant peak caused by a single-channel continuum effect.

  6. Inclusive J/{psi} Production in {Upsilon} Decay Via Color-Singlet Mechanism

    SciTech Connect

    He Zhiguo; Wang Jianxiong

    2011-05-23

    We report the recent works about the inclusive J/{psi} production in {Upsilon} decay. Our results show that until now the color-singlet (CS) contribution which includes leading order ({alpha}{sub s}{sup 5}){Upsilon}{yields}J/{psi}+cc-barg process and {alpha}{sub s}{sup 6} order {Upsilon}{yields}J/{psi}+gg(4g) process as well as {alpha}{sub s}{sup 2{alpha}2} order {Upsilon}{yields}J/{psi}+cc-bar and {Upsilon}{yields}J/{psi}+gg processes can not explain the experimental data yet. A preliminary CS prediction of R{sub cc} (B({Upsilon}{yields}J/{psi}+cc-bar+X)/B({Upsilon}{yields}J/{psi}+X)) 0.39{sub -0.20}{sup +0.21}, which is much larger than color-octet (CO) prediction, is also given as a good quantity to discriminate the CS and color-octet mechanism.

  7. Maslinic Acid, a Natural Triterpene, Induces a Death Receptor-Mediated Apoptotic Mechanism in Caco-2 p53-Deficient Colon Adenocarcinoma Cells

    PubMed Central

    Reyes-Zurita, Fernando J.; Rufino-Palomares, Eva E.; García-Salguero, Leticia; Peragón, Juan; Medina, Pedro P.; Parra, Andrés; Cascante, Marta; Lupiáñez, José A.

    2016-01-01

    Maslinic acid (MA) is a natural triterpene present in high concentrations in the waxy skin of olives. We have previously reported that MA induces apoptotic cell death via the mitochondrial apoptotic pathway in HT29 colon cancer cells. Here, we show that MA induces apoptosis in Caco-2 colon cancer cells via the extrinsic apoptotic pathway in a dose-dependent manner. MA triggered a series of effects associated with apoptosis, including the cleavage of caspases -8 and -3, and increased the levels of t-Bid within a few hours of its addition to the culture medium. MA had no effect on the expression of the Bax protein, release of cytochrome-c or on the mitochondrial membrane potential. This suggests that MA triggered the extrinsic apoptotic pathway in this cell type, as opposed to the intrinsic pathway found in the HT29 colon-cancer cell line. Our results suggest that the apoptotic mechanism induced in Caco-2 may be different from that found in HT29 colon-cancer cells, and that in Caco-2 cells MA seems to work independently of p53. Natural antitumoral agents capable of activating both the extrinsic and intrinsic apoptotic pathways could be of great use in treating colon-cancer of whatever origin. PMID:26751572

  8. A program for undergraduate research into the mechanisms of sensory coding and memory decay

    SciTech Connect

    Calin-Jageman, R J

    2010-09-28

    This is the final technical report for this DOE project, entitltled "A program for undergraduate research into the mechanisms of sensory coding and memory decay". The report summarizes progress on the three research aims: 1) to identify phyisological and genetic correlates of long-term habituation, 2) to understand mechanisms of olfactory coding, and 3) to foster a world-class undergraduate neuroscience program. Progress on the first aim has enabled comparison of learning-regulated transcripts across closely related learning paradigms and species, and results suggest that only a small core of transcripts serve truly general roles in long-term memory. Progress on the second aim has enabled testing of several mutant phenotypes for olfactory behaviors, and results show that responses are not fully consistent with the combinitoral coding hypothesis. Finally, 14 undergraduate students participated in this research, the neuroscience program attracted extramural funding, and we completed a successful summer program to enhance transitions for community-college students into 4-year colleges to persue STEM fields.

  9. Two-step mechanisms of two-proton decays of nuclei

    NASA Astrophysics Data System (ADS)

    Kadmensky, S. G.; Ivankov, Yu. V.

    2014-08-01

    A formalism for describing two-step two-proton decays of nuclei is developed on the basis of the multiparticle theory of deep-subbarrier one-proton decays of nuclei that employs integral expression for the decay widths in question. This formalism relies on the idea that the interaction between the emitted protons has but a slight effect on the widths with respect to the two-proton decays being considered. It is shown that such a decay is naturally broken down into the sequential one-proton decays of an ( A, Z) parent nucleus and an ( A - 1, Z - 1) intermediate nucleus, these decays being related by the Green's function G( A - 1, Z - 1) that describes the intermediate nucleus with allowance for its real and virtual states, which give rise to, respectively, the sequential and the virtual two-step two-proton decay of the parent nucleus. It is also shown that the widths with respect to sequential two-step two-proton decays coincide with the analogous widths constructed within the R-matrix theory of nuclear reactions leading to the production of unstable particles and with their counterparts obtained with the aid of solving the set of kinetic equations for the chain of nuclei undergoing radioactive decays. It is found that the widths with respect to virtual two-step two-proton decays are close in structure to the widths constructed for the simultaneous two-proton decays of nuclei by using integrated formulas within a simplified model of the method of three-particle hyperspherical polynomials.

  10. MALDI In-Source Decay of Protein: The Mechanism of c-Ion Formation

    PubMed Central

    Takayama, Mitsuo

    2016-01-01

    The in-source decay (ISD) phenomenon, the fragmentation at an N–Cα bond of a peptide backbone that occurs within several tens of nanoseconds in the ion-source in matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS), is discussed from the standpoints of the discovery and early publications dealing with MALDI-ISD, the formation of c-ions in energy-sudden desorption/ionization methods, the formation of radical species in a MALDI, model construction for ISD, and matrix materials that are suitable for use in MALDI-ISD. The formation of c-ions derived from peptides and proteins in MALDI-ISD can be rationalized by a mechanism involving intermolecular hydrogen transfer, denoted as the “Takayama’s model” by De Pauw’s group (Anal. Chem. 79: 8678–8685, 2007). It should be emphasized that the model for MALDI-ISD was constructed on the basis of X-ray crystallography and scanning probe microscopy (SPM) analyses of matrix crystals, as well as the use of isotopically-labelled peptides. PMID:27162707

  11. Non-adiabatic dynamics investigation of the radiationless decay mechanism of trans-urocanic acid in the S2 state

    NASA Astrophysics Data System (ADS)

    Zhao, Li; Zhou, Pan-Wang; Zhao, Guang-Jiu

    2016-07-01

    The trans-urocanic acid, a UV chromophore in the epidermis of human skin, was found to exhibit a wavelength dependent isomerization property. The isomerization quantum yield to cis-urocanic is greatest when being excited to the S1 state, whereas exciting the molecule to the S2 state causes almost no isomerization. The comparative photochemical behavior of the trans-urocanic on the S1 and S2 states continues to be the subject of intense research effort. This study is concerned with the unique photo-behavior of this interesting molecule on the S2 state. Combining the on-the-fly surface hopping dynamics simulations and static electronic structure calculations, three decay channels were observed following excitation to the S2 state. An overwhelming majority of the molecules decay to the S1 state through a planar or pucker characterized minimum energy conical intersection (MECI), and then decay to the ground state along a relaxation coordinate driven by a pucker deformation of the ring. A very small fraction of molecules decay to the S1 state by a MECI characterized by a twisting motion around the CC double bond, which continues to drive the molecule to deactivate to the ground state. The latter channel is related with the photoisomerization process, whereas the former one will only generate the original trans-form products. The present work provides a novel S2 state decay mechanism of this molecule, which offers useful information to explain the wavelength dependent isomerization behavior.

  12. Effect of hot air treatment on postharvest mould decay in Chinese bayberry fruit and the possible mechanisms.

    PubMed

    Wang, Kaituo; Cao, Shifeng; Jin, Peng; Rui, Huaijing; Zheng, Yonghua

    2010-06-30

    The effect of hot air treatment (HAT) on reducing natural fungal decay and green mould decay caused by Leptographium abietinum on postharvest Chinese bayberry fruit and the possible mechanisms were investigated. Freshly harvested Chinese bayberry fruit were firstly pretreated with hot air at 36-60 degrees C for 1-3h, and then stored at 20 degrees C for 3d or at 1 degrees C for 12d to investigate the optimum condition of hot air treatment (HAT) for inhibiting decay development. Results demonstrated that HAT at 48 degrees C for 3h was the most effective in reducing natural decay without impairing quality. This treatment also enhanced the resistance of Chinese bayberry fruit against green mould rot caused by L. abietinum and reduced the severity of the disease. The activities of defense-related enzymes including chitinase, beta-1, 3-glucanase, peroxidase and polyphenol oxidase were significantly enhanced by HAT. In addition, the in vitro experiment showed that HAT significantly inhibited spore germination, germ tube elongation and mycelial growth of L. abietinum. These results indicate that HAT can effectively reduce fruit decay possibly by directly inhibiting pathogen growth and indirectly inducing disease resistance.

  13. Ultrafast excited state dynamics of 5,6-dihydroxyindole, a key eumelanin building block: nonradiative decay mechanism.

    PubMed

    Gauden, Magdalena; Pezzella, Alessandro; Panzella, Lucia; Napolitano, Alessandra; d'Ischia, Marco; Sundström, Villy

    2009-09-17

    As part of a program designed to elucidate the excited state properties of key eumelanin building blocks, we report herein a study of 5,6-dihydroxyindole (DHI) in phosphate buffer at pH 3 and pH 7 using femtosecond transient absorption spectroscopy. The transient absorption changes following excitation at 266 nm were used to directly monitor relaxation of the excited states. It was found that the initially generated excited state of DHI, exhibiting two main absorption bands at approximately 450 and approximately 550 nm, decays with a time constant of 5-10 ps to the equilibrated singlet excited state characterized by a very similar spectrum. This latter state then decays to the ground state and the triplet state with a characteristic time of approximately 140-180 ps. Concomitant with the singlet excited state decay of DHI, spectral features characteristic of the DHI cation radical (band at approximately 575 nm) and the triplet state (band at 440-450 nm) are detected. These species do not decay further since geminate recombination of the solvated electron and the DHI radical cation, as well as deprotonation of the cation to form the neutral semiquinone radical, occur on a time scale longer than that covered by the present experiments. These results offer novel insights into the mechanisms of nonradiative decay of eumelanin building blocks of possible relevance to the putative photoprotective and phototoxic roles of these biopolymers.

  14. Non-adiabatic dynamics investigation of the radiationless decay mechanism of trans-urocanic acid in the S2 state.

    PubMed

    Zhao, Li; Zhou, Pan-Wang; Zhao, Guang-Jiu

    2016-07-28

    The trans-urocanic acid, a UV chromophore in the epidermis of human skin, was found to exhibit a wavelength dependent isomerization property. The isomerization quantum yield to cis-urocanic is greatest when being excited to the S1 state, whereas exciting the molecule to the S2 state causes almost no isomerization. The comparative photochemical behavior of the trans-urocanic on the S1 and S2 states continues to be the subject of intense research effort. This study is concerned with the unique photo-behavior of this interesting molecule on the S2 state. Combining the on-the-fly surface hopping dynamics simulations and static electronic structure calculations, three decay channels were observed following excitation to the S2 state. An overwhelming majority of the molecules decay to the S1 state through a planar or pucker characterized minimum energy conical intersection (MECI), and then decay to the ground state along a relaxation coordinate driven by a pucker deformation of the ring. A very small fraction of molecules decay to the S1 state by a MECI characterized by a twisting motion around the CC double bond, which continues to drive the molecule to deactivate to the ground state. The latter channel is related with the photoisomerization process, whereas the former one will only generate the original trans-form products. The present work provides a novel S2 state decay mechanism of this molecule, which offers useful information to explain the wavelength dependent isomerization behavior. PMID:27475370

  15. Updated constraints on the light-neutrino exchange mechanisms of the 0νββ-decay

    NASA Astrophysics Data System (ADS)

    Štefánik, Dušan; Dvornický, Rastislav; Šimkovic, Fedor

    2015-10-01

    The neutrinoless double-beta (0νββ) decay associated with light neutrino exchange mechanisms, which are due to both left-handed V-A and right-handed V+A leptonic and hadronic currents, is discussed by using the recent progress achieved by the GERDA, EXO and KamlandZen experiments. The upper limits for effective neutrino mass mββ and the parameters <λ> and <η> characterizing the right handed current mechanisms are deduced from the data on the 0νββ-decay of 76Ge and 136Xe using nuclear matrix elements calculated within the nuclear shell model and quasiparticle random phase approximation and phase-space factors calculated with exact Dirac wave functions with finite nuclear size and electron screening. The careful analysis of upper constraints on effective lepton number violating parameters assumes a competition of the above mechanisms and arbitrary values of involved CP violating phases.

  16. Proton-transfer mechanism for dispersed decay kinetics of single molecules isolated in potassium hydrogen phthalate.

    PubMed

    Bott, Eric D; Riley, Erin A; Kahr, Bart; Reid, Philip J

    2009-08-25

    The excited-state decay kinetics of single 2',7'-dichlorofluorescein (DCF) molecules oriented and overgrown within crystals of potassium acid phthalate (KAP) are reported. Time-correlated single-photon counting measurements (TCSPC) of 56 DCF molecules in KAP reveal that single-exponential decay is exhibited by roughly half of the molecules. The remainder demonstrates complex excited-state decay kinetics that are well fit by a stretched exponential function consistent with dispersed kinetics. Histograms of single-molecule luminescence energies revealed environmental fluctuations and distinct chemical species. The TCSPC results are compared to Monte Carlo simulations employing a first-passage model for excited-state decay. Agreement between experiment and theory, on both bulk and single-molecule levels, suggests that a subset of the DCF molecules in KAP experience fluctuations in the surrounding environment that modify the energy barrier to proton transfer leading to dispersed kinetics.

  17. Influence of heat treatments upon the mechanical properties and in vitro bioactivity of ZrO2-toughened MgO-CaO-SiO2-P2O5-CaF2 glass-ceramics.

    PubMed

    Li, Huan-Cai; Wang, Dian-Gang; Meng, Xiang-Guo; Chen, Chuan-Zhong

    2014-09-01

    Zirconia-toughened MgO-CaO-SiO2-P2O5-CaF2 glass-ceramics are prepared using sintering techniques, and a series of heat treatment procedures are designed to obtain a glass-ceramic with improved properties. The crystallization behavior, phase composition, and morphology of the glass-ceramics are characterized. The bending strength, elastic modulus, fracture toughness, and microhardness of the glass-ceramics are investigated, and the effect mechanism of heat treatments upon the mechanical properties is discussed. The bioactivity of glass-ceramics is then evaluated using the in vitro simulated body fluid (SBF) soaking test, and the mechanism whereby apatite forms on the glass-ceramic surfaces in the SBF solution is discussed. The results indicate that the main crystal phase of the G-24 sample undergoing two heat treatment procedures is Ca5(PO4)3F (fluorapatite), and those of the G-2444 sample undergoing four heat treatment procedures are Ca5(PO4)3F and β-CaSiO3 (β-wollastonite). The heat treatment procedures are found to greatly influence the mechanical properties of the glass-ceramic, and an apatite layer is induced on the glass-ceramic surface after soaking in the SBF solution.

  18. The influence of an electrostatic precipitator and a mechanical filter on Rn decay products.

    PubMed

    Rajala, M; Janka, K; Lehtimäki, M; Kulmala, V; Graeffe, G

    1986-04-01

    In the present work the effect of an HEPA filter and an electrostatic precipitator on the behaviour of Rn decay products has been studied in laboratory conditions. Both filters were found to decrease the equilibrium factor of progeny and increase the unattached fraction of decay products. In a clean air they also decreased the activity of unattached progeny. An electrostatic precipitator was found to produce condensation nuclei which were observable when no other particle sources were present. The ozone produced by the corona discharge of the filter probably has a great effect on the production of these submicron particles. The impurities of the air were found to grow the particles and thus their influence on the behaviour of Rn decay products became in some cases significant.

  19. {upsilon} decay to two charm-quark jets as a probe of the color-octet mechanism

    SciTech Connect

    Zhang Yujie; Chao Kuangta

    2008-11-01

    We calculate the decay rate of bottomonium to two charm-quark jets {upsilon}{yields}cc at the tree level and one-loop level including color-singlet and color-octet bb annihilations. We find that the short-distance coefficient of the color-octet piece is much larger than the color-singlet piece, and that the QCD correction will change the end point behavior of the charm quark jet. The color-singlet piece is strongly affected by the one-loop QCD correction. In contrast, the QCD correction to the color-octet piece is weak. Once the experiment can measure the branching ratio and energy distribution of the two charm-quark jets in the {upsilon} decay, the result can be used to test the color-octet mechanism or give a strong constraint on the color-octet matrix elements.

  20. An ab initio Study of Decay Mechanism of Adenine: the Facile Path of the Amino NH Bond Cleavage

    NASA Astrophysics Data System (ADS)

    Conti, Irene; Garavelli, Marco; Orlandi, Giorgio

    2007-12-01

    A comprehensive study of the radiationless decay processes of the lowest excited singlet states in the isolated 9H-Adenine has been performed at the CASPT2//CASSCF level. The minimum energy paths of the La, Lb and nπ* singlet states along different skeletal distortions have been computed and the Conical Intersections (CIs) involving these states have been determined. The fast deactivation path of La along a skeletal deformation, which leads to a S0/La CI, as previously discussed, is confirmed. Moreover, low-lying CIs between S0 and πσ* singlet states have been characterized, where σ* is the antibonding orbital localized on a N-H bond of the amino (πσNH2*) or of the azine group (πσN9H*). We have found that the repulsive πσNH2* state associated with an amino N-H bond can be populated through a barrierless way. Therefore, the decay path shows a bifurcation leading to two possible ways of radiationless deactivation: on one hand a non-photochemical decay through the S0/La or S0/nπ* CIs and on the other hand a photochemical process via the possible access to the S0/πσNH2* CI that produces N-H cleavage. In this way, we can explain the H atom loss found upon UV excitation. We have considered also the decay of higher energy bright states. We have found that these states can decay also by converting to the repulsive πσN9H* state associated with the azine NH bond. This new channel suggests an increase of H-atom photoproduction yield by excitating Adenine with lower wavelength radiations. The study of the decay processes of an Adenine molecule in the double strand d(A)10ṡd(T)10 in water solvent is currently underway: Adenine is treated by the Quantum Mechanical (QM) approach and the remaining molecules are described at the Molecular Mechanics (MM) level. We use the COBRAMM program that is a tunable QM/MM approach to complex molecular architectures developed by our research group.

  1. 2p2 Team News

    NASA Astrophysics Data System (ADS)

    Jones, H.

    2000-06-01

    The 2p2 Team continued towards the implementation at the 2.2-m of the same BOB (Broker for Observation Blocks) observing interface as seen at other ESO telescopes. This requires an interface to be written between the existing BOB software and the non-VLT compatible control software for the Wide-Field Imager (WFI) and 2.2-m. Cristian Urrutia, Tatiana Paz and Eduardo Robledo are heading its development. With this software in place, observers can use the VLT Phase 2 Proposal Preparation System (P2PP) for definition of their exposures, whether they are for Visitor or Service Mode.

  2. Photoionization studies of the 2p resonances of atomic calcium

    NASA Astrophysics Data System (ADS)

    Obst, B.; Hansen, J. E.; Sonntag, B.; Wernet, Ph.; Zimmermann, P.

    2002-06-01

    The Ca 2p resonances at 345-355 eV were studied by photoion and photoelectron spectroscopy using monochromatized synchrotron radiation and atomic-beam technique. The analysis of the excitation and decay of these resonances shows strong configuration mixing between the different subshells of the valence electrons 4s, 3d, and 4p. In the case of the 2p-13/2 resonance structure at 348 eV there are two excited states with nearly equal contributions from the configuration 2p53d4s2 and 2p53d24s, which gives rise to strong variations of the resonantly enhanced 3p4(3d,4s)3 photoelectron lines when scanning the photon energy across the resonance.

  3. Lepton flavor violating {tau} decays in the type-III seesaw mechanism

    SciTech Connect

    Arhrib, Abdesslam; Benbrik, Rachid; Chen, C.-H.

    2010-06-01

    In this paper, the lepton flavor violating {tau}{yields}lP(V) (P, V={pi}{sup 0}, {eta}, {eta}{sup '}, {rho}{sup 0}, {omega}, {phi}) and {tau}{yields}3l (l=e, {mu}) decays are studied in the framework of the type-III seesaw model, in which new triplet fermions with a zero hypercharge (Y=0) interact with ordinary lepton doublets via Yukawa couplings, and affect tree-level leptonic Z-boson couplings. We investigate the experimental bound from the leptonic Z decay to get constraints on the existing parameters space. We predict that the upper limits on the branching ratios of {tau}{yields}lP(V) and {tau}{yields}3l can reach the experimental current limits.

  4. Production mechanisms and signatures of isosinglet neutral heavy leptons in Z 0 decays

    NASA Astrophysics Data System (ADS)

    Dittmar, M.; Santamaria, A.; Gonzalez-Garcia, M. C.; Valle, J. W. F.

    1990-02-01

    Neutral Heavy Leptons (NHLs) arise in many extensions of the standard electroweak theory such as superstring inspired models. The possibility of gauge singlets NHLs is especially attractive because it gives an explanation for the observed smallness of the neutrino mass. Existing limits on the possible existence of such particles are still fairly poor. We have investigated isosinglet NHL production and decays within different models. The dominant production cross section is single production (i.e. Z0 → N + overlineνor Z0 → overlineN + ν ) as a result of mixing with the standard doublet neutrinos. Subsequent NHL decays lead to striking signatures. Taking into account the expected luminosities and typical detector efficiencies of the different LEP/SLC experiments we conclude that these may discover isosinglet NHLs or else substantially improve and extend present limits on their mass and coupling strength.

  5. Evolutionary Perspectives on Diversity of Lignocellulose Decay Mechanisms in Basidionycetes (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    SciTech Connect

    Hibbett, David

    2012-03-21

    David Hibbett from Clark University on "Evolutionary Perspectives on Diversity of Lignocellulose Decay Mechanisms in Basidiomycetes" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, California.

  6. Evolutionary Perspectives on Diversity of Lignocellulose Decay Mechanisms in Basidionycetes (JGI Seventh Annual User Meeting 2012: Genomics of Energy and Environment)

    ScienceCinema

    Hibbett, David [Clark University

    2016-07-12

    David Hibbett from Clark University on "Evolutionary Perspectives on Diversity of Lignocellulose Decay Mechanisms in Basidiomycetes" at the 7th Annual Genomics of Energy & Environment Meeting on March 21, 2012 in Walnut Creek, California.

  7. Effect of ZrO(2) additions on the crystallization, mechanical and biological properties of MgO-CaO-SiO(2)-P(2)O(5)-CaF(2) bioactive glass-ceramics.

    PubMed

    Li, H C; Wang, D G; Meng, X G; Chen, C Z

    2014-06-01

    A series of ZrO(2) doped MgO-CaO-SiO(2)-P(2)O(5)-CaF(2) bioactive glass-ceramics were obtained by sintering method. The crystallization behavior, phase composition, morphology and structure of glass-ceramics were characterized. The bending strength, elastic modulus, fracture toughness, micro-hardness and thermal expansion coefficient (TEC) of glass-ceramics were investigated. The in vitro bioactivity and cytotoxicity tests were used to evaluate the bioactivity and biocompatibility of glass-ceramics. The sedimentation mechanism and growth process of apatites on sample surface were discussed. The results showed that the mainly crystalline phases of glass-ceramics were Ca(5)(PO4)3F (fluorapatite) and β-CaSiO(3). (β-wollastonite). m-ZrO(2) (monoclinic zirconia) declined the crystallization temperatures of glasses. t-ZrO(2) (tetragonal zirconia) increased the crystallization temperature of Ca(5)(PO4)(3)F and declined the crystallization temperature of β-CaSiO(3). t-ZrO(2) greatly increased the fracture toughness, bending strength and micro-hardness of glass-ceramics. The nanometer apatites were induced on the surface of glass-ceramic after soaking 28 days in SBF (simulated body fluid), indicating the glass-ceramic has good bioactivity. The in vitro cytotoxicity test demonstrated the glass-ceramic has no toxicity to cell.

  8. Biocontrol of postharvest gray and blue mold decay of apples with Rhodotorula mucilaginosa and possible mechanisms of action.

    PubMed

    Li, Renping; Zhang, Hongyin; Liu, Weimin; Zheng, Xiaodong

    2011-03-30

    The efficacy of Rhodotorula mucilaginosa against postharvest gray mold, blue mold and natural decay development of apples and the possible mechanisms involved were investigated. The decay incidence and lesion diameter of gray mold and blue mold of apples treated by R. mucilaginosa were significantly reduced compared with the control fruits, and the higher concentration of R. mucilaginosa, the better the efficacy of the biocontrol. R. mucilaginosa also significantly reduced the natural decay development of apples following storage at 20°C for 35 days or at 4°C for 45 days followed by 20°C for 15 days. Germination and survival of spores of Penicillium expansum and Botrytis cinerea were markedly inhibited by R. mucilaginosa in an in vitro test. Rapid colonization of the yeast in apple wounds was observed whether stored at 20°C or 4°C. In apples, the activities of peroxidase (POD) and polyphenoloxidase (PPO) were significantly induced and lipid peroxidation (malondialdehyde (MDA) content) was highly inhibited by R. mucilaginosa treatment compared with those of the control fruits. All these results indicated that R. mucilaginosa has great potential for development of commercial formulations to control postharvest pathogens on fruits. Its modes of action were based on competition for space and nutrients with pathogens, inducement of activities of defense-related enzymes such as POD, PPO and inhibition of lipid peroxidation (MDA content) of apples, so as to enhance the resistance and delay the ripening and senescence of apples.

  9. Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells.

    PubMed

    Schweingruber, Christoph; Rufener, Simone C; Zünd, David; Yamashita, Akio; Mühlemann, Oliver

    2013-01-01

    The nonsense-mediated mRNA decay (NMD) pathway is well known as a translation-coupled quality control system that recognizes and degrades aberrant mRNAs with truncated open reading frames (ORF) due to the presence of a premature termination codon (PTC). However, a more general role of NMD in posttranscriptional regulation of gene expression is indicated by transcriptome-wide mRNA profilings that identified a plethora of physiological mRNAs as NMD targets. In this review, we focus on mechanistic aspects of target mRNA identification and degradation in mammalian cells, based on the available biochemical and genetic data, and point out knowledge gaps. Translation termination in a messenger ribonucleoprotein particle (mRNP) environment lacking necessary factors for proper translation termination emerges as a key determinant for subjecting an mRNA to NMD, and we therefore review recent structural and mechanistic insight into translation termination. In addition, the central role of UPF1, its crucial phosphorylation/dephosphorylation cycle and dynamic interactions with other NMD factors are discussed. Moreover, we address the role of exon junction complexes (EJCs) in NMD and summarize the functions of SMG5, SMG6 and SMG7 in promoting mRNA decay through different routes. This article is part of a Special Issue entitled: RNA Decay mechanisms.

  10. Updated constraints on the light-neutrino exchange mechanisms of the 0νββ-decay

    SciTech Connect

    Štefánik, Dušan; Dvornický, Rastislav; Šimkovic, Fedor

    2015-10-28

    The neutrinoless double-beta (0νββ) decay associated with light neutrino exchange mechanisms, which are due to both left-handed V-A and right-handed V+A leptonic and hadronic currents, is discussed by using the recent progress achieved by the GERDA, EXO and KamlandZen experiments. The upper limits for effective neutrino mass m{sub ββ} and the parameters 〈λ〉 and 〈η〉 characterizing the right handed current mechanisms are deduced from the data on the 0νββ-decay of {sup 76}Ge and {sup 136}Xe using nuclear matrix elements calculated within the nuclear shell model and quasiparticle random phase approximation and phase-space factors calculated with exact Dirac wave functions with finite nuclear size and electron screening. The careful analysis of upper constraints on effective lepton number violating parameters assumes a competition of the above mechanisms and arbitrary values of involved CP violating phases.

  11. Laser studies of radiationless decay mechanisms in Os/sup 2 +///sup 3 +/ polypyridine complexes

    SciTech Connect

    Netzel, T.L.; Bergkamp, M.A.

    1982-01-01

    The lowest energy excited states in Os(II) polypyridine complexes are of a metal-to-ligand charge transfer (MLCT) type and live for 10 to 40 ..mu..s at 4.2/sup 0/K. The long wavelength absorptions in the visible region of the spectrum in Os(III) polypyridine complexes arise from ligand-to-metal charge transfer (LMCT) transitions and do not produce detectable luminescence. This suggests that these LMCT states are very short lived. Results of picosecond absorption studies on the lifetimes the LMCT states in OsL/sub 3//sup 3 +/ complexes (L = 2,2'-bipyridine(bpy) or 1,10-phenanthroline(phen)) as functions of temperature and isotopic substitution are reported. The LMCT lifetimes at low temperature are contrasted with the low temperature lifetimes of the MLCT states of OsL/sub 3//sup 2 +/ complexes and both are examined from the perspective of a coarse-grained radiationless decay theory developed by Englman, R. and Jortner, J. (Molec. Phys. 1970, 18, 145). The agreement between experiment and theory suggests the following: (1) Englman and Jortner's theory of radiationless decay is useful for inorganic as well as organic systems; (2) mid-frequency (1300 to 1600 cm/sup -1/) vibrations are the important energy accepting modes for radiationless decay of the charge transfer excited states of OsL/sub 3//sup 2 +///sup 3 +/ complexes and; (3) the 10/sup 5/-10/sup 6/ difference in lifetimes between the MLCT states of OsL/sub 3//sup 2 +/ complexes and the LMCT states of OsL/sub 3//sup 3 +/ complexes is largely due to the difference in their energy gaps.

  12. Decay of a quantum-mechanical state described by a truncated Lorentzian energy distribution

    NASA Astrophysics Data System (ADS)

    Sluis, Kathleen M.; Gislason, Eric A.

    1991-05-01

    The nondecay probability Q(t) for a Lorentzian energy distribution peaked at E0 with full width at half maximum equal to Γ is given in atomic units by QL(t)=exp(-Γt). However, the Lorentzian distribution includes energies in the range -∞<=E<=∞. On physical grounds, this distribution must be truncated at some minimum energy E=0. In this paper, Q(t) is derived for a properly normalized truncated Lorentzian energy distribution. To aid the analysis, the average lifetime τ(tmin) for that fraction of the system that has not decayed by tmin is also calculated for this system. For a given value of the ratio E0/Γ, the function Q(t) shows different behavior in different time regimes; this behavior is presented and the time periods are determined. It is shown that Q(t) falls off linearly at very small t, but at a rate only half as fast as for QL(t). Thus this system cannot exhibit the behavior known as Zeno's paradox, but rapid measurements on this system that collapse the wave function back to the original state could, in principle, reduce the decay rate by a factor of 2.

  13. Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists.

    PubMed

    Kohler, Annegret; Kuo, Alan; Nagy, Laszlo G; Morin, Emmanuelle; Barry, Kerrie W; Buscot, Francois; Canbäck, Björn; Choi, Cindy; Cichocki, Nicolas; Clum, Alicia; Colpaert, Jan; Copeland, Alex; Costa, Mauricio D; Doré, Jeanne; Floudas, Dimitrios; Gay, Gilles; Girlanda, Mariangela; Henrissat, Bernard; Herrmann, Sylvie; Hess, Jaqueline; Högberg, Nils; Johansson, Tomas; Khouja, Hassine-Radhouane; LaButti, Kurt; Lahrmann, Urs; Levasseur, Anthony; Lindquist, Erika A; Lipzen, Anna; Marmeisse, Roland; Martino, Elena; Murat, Claude; Ngan, Chew Y; Nehls, Uwe; Plett, Jonathan M; Pringle, Anne; Ohm, Robin A; Perotto, Silvia; Peter, Martina; Riley, Robert; Rineau, Francois; Ruytinx, Joske; Salamov, Asaf; Shah, Firoz; Sun, Hui; Tarkka, Mika; Tritt, Andrew; Veneault-Fourrey, Claire; Zuccaro, Alga; Tunlid, Anders; Grigoriev, Igor V; Hibbett, David S; Martin, Francis

    2015-04-01

    To elucidate the genetic bases of mycorrhizal lifestyle evolution, we sequenced new fungal genomes, including 13 ectomycorrhizal (ECM), orchid (ORM) and ericoid (ERM) species, and five saprotrophs, which we analyzed along with other fungal genomes. Ectomycorrhizal fungi have a reduced complement of genes encoding plant cell wall-degrading enzymes (PCWDEs), as compared to their ancestral wood decayers. Nevertheless, they have retained a unique array of PCWDEs, thus suggesting that they possess diverse abilities to decompose lignocellulose. Similar functional categories of nonorthologous genes are induced in symbiosis. Of induced genes, 7-38% are orphan genes, including genes that encode secreted effector-like proteins. Convergent evolution of the mycorrhizal habit in fungi occurred via the repeated evolution of a 'symbiosis toolkit', with reduced numbers of PCWDEs and lineage-specific suites of mycorrhiza-induced genes.

  14. Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists

    DOE PAGES

    Kohler, Annegret; Kuo, Alan; Nagy, Laszlo G.; Morin, Emmanuelle; Barry, Kerrie W.; Buscot, Francois; Canbäck, Björn; Choi, Cindy; Cichocki, Nicolas; Clum, Alicia; et al

    2015-02-23

    To elucidate the genetic bases of mycorrhizal lifestyle evolution, we sequenced new fungal genomes, including 13 ectomycorrhizal (ECM), orchid (ORM) and ericoid (ERM) species, and five saprotrophs, which we analyzed along with other fungal genomes. Ectomycorrhizal fungi have a reduced complement of genes encoding plant cell wall-degrading enzymes (PCWDEs), as compared to their ancestral wood decayers. Nevertheless, they have retained a unique array of PCWDEs, thus suggesting that they possess diverse abilities to decompose lignocellulose. Similar functional categories of nonorthologous genes are induced in symbiosis. Of induced genes, 7-38% are orphan genes, including genes that encode secreted effector-like proteins. Convergentmore » evolution of the mycorrhizal habit in fungi occurred via the repeated evolution of a 'symbiosis toolkit', with reduced numbers of PCWDEs and lineage-specific suites of mycorrhiza-induced genes.« less

  15. Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in mycorrhizal mutualists

    SciTech Connect

    Kohler, Annegret; Kuo, Alan; Nagy, Laszlo G.; Morin, Emmanuelle; Barry, Kerrie W.; Buscot, Francois; Canbäck, Björn; Choi, Cindy; Cichocki, Nicolas; Clum, Alicia; Colpaert, Jan; Copeland, Alex; Costa, Mauricio D.; Doré, Jeanne; Floudas, Dimitrios; Gay, Gilles; Girlanda, Mariangela; Henrissat, Bernard; Herrmann, Sylvie; Hess, Jaqueline; Högberg, Nils; Johansson, Tomas; Khouja, Hassine-Radhouane; LaButti, Kurt; Lahrmann, Urs; Levasseur, Anthony; Lindquist, Erika A.; Lipzen, Anna; Marmeisse, Roland; Martino, Elena; Murat, Claude; Ngan, Chew Y.; Nehls, Uwe; Plett, Jonathan M.; Pringle, Anne; Ohm, Robin A.; Perotto, Silvia; Peter, Martina; Riley, Robert; Rineau, Francois; Ruytinx, Joske; Salamov, Asaf; Shah, Firoz; Sun, Hui; Tarkka, Mika; Tritt, Andrew; Veneault-Fourrey, Claire; Zuccaro, Alga; Tunlid, Anders; Grigoriev, Igor V.; Hibbett, David S.; Martin, Francis

    2015-02-23

    To elucidate the genetic bases of mycorrhizal lifestyle evolution, we sequenced new fungal genomes, including 13 ectomycorrhizal (ECM), orchid (ORM) and ericoid (ERM) species, and five saprotrophs, which we analyzed along with other fungal genomes. Ectomycorrhizal fungi have a reduced complement of genes encoding plant cell wall-degrading enzymes (PCWDEs), as compared to their ancestral wood decayers. Nevertheless, they have retained a unique array of PCWDEs, thus suggesting that they possess diverse abilities to decompose lignocellulose. Similar functional categories of nonorthologous genes are induced in symbiosis. Of induced genes, 7-38% are orphan genes, including genes that encode secreted effector-like proteins. Convergent evolution of the mycorrhizal habit in fungi occurred via the repeated evolution of a 'symbiosis toolkit', with reduced numbers of PCWDEs and lineage-specific suites of mycorrhiza-induced genes.

  16. Silylene extrusion from organosilanes via double geminal Si-H bond activation by a Cp*Ru(kappa2-P,N)+ complex: observation of a key stoichiometric step in the glaser-tilley alkene hydrosilylation mechanism.

    PubMed

    Rankin, Matthew A; MacLean, Darren F; Schatte, Gabriele; McDonald, Robert; Stradiotto, Mark

    2007-12-26

    Treatment of Cp*RuCl(kappa2-P,N-2b) (2b = 2-NMe2-3-PiPr2-indene) with TlSO3CF3 produced the cyclometalated complex [4]+SO3CF3- in 94% isolated yield. Exposure of [4]+X- (X = B(C6F5)4 or SO3CF3) to Ph2SiH2 (10 equiv) or PhSiH3 afforded the corresponding [Cp*(mu-P,N-2b)(H)2Ru=SiRPh]+X- complexes, [5]+X- (R = Ph; X = B(C6F5)4, 82%; X = SO3CF3, 39%) and [6]+X- (R = H; X = B(C6F5)4, 94%; X = SO3CF3, 95%). Notably, these transformations represent the first documented examples of Ru-mediated silylene extrusion via double geminal Si-H bond activation of an organosilane-a key step in the recently proposed Glaser-Tilley (G-T) alkene hydrosilylation mechanism. Treatment of [5]+B(C6F5)4- with KN(SiMe3)2 or [6]+SO3CF3- with NaN(SiMe3)2 afforded the corresponding zwitterionic Cp*(mu-2-NMe2-3-PiPr2-indenide)(H)2Ru=SiRPh complex in 69% (R = Ph, 7) or 86% (R = H, 8) isolated yield. Both [6]+X- and 8 proved unreactive toward 1-hexene and styrene and provided negligible catalytic turnover in the attempted metal-mediated hydrosilylation of these substrates with PhSiH3, thereby providing further empirical evidence for the required intermediacy of base-free Ru=Si species in the G-T mechanism. Isomerization of the P,N-indene ligand backbone in [6]+X-, giving rise to [Cp*(mu-1-PiPr2-2-NMe2-indene)(H)2Ru=SiHPh]+X- ([9]+X-), was observed. In the case of [9]+SO3CF3-, net intramolecular addition of the Ru=Si-H group across the styrene-like C=C unit within the ligand backbone to give 10 (96% isolated yield) was observed. Crystallographic characterization data are provided for [4]+X-, [5]+X-, [6]+X-, 8, and 10.

  17. Laser studies of radiationless decay mechanisms in Os/sup 2+/3+/ polypyridine complexes

    SciTech Connect

    Netzel, T.L.; Bergkamp, M.A.

    1983-01-01

    The results of picosecond absorption studies show a lack of significant change with decreasing temperature (295 K to 10 K) on the lifetimes of the ligand-to-metal charge transfer (LMCT) in the OsL/sub 3//sup 3 +/ complexes; L = 2,2' bipryridine (bpy) or 1,10 phenanthroline(phen). The LMCT lifetimes at low temperature are then contrasted with the low temperature lifetimes of the metal-to-ligand charge transfer (MLCT) states of the OsL/sub 3//sup 2 +/ complexes and both are examined from the perspective of a radiationless theory developed by Englman and Jortner. Mid-frequency vibrations (1300-1600 cm/sup -1/) are the important energy accepting modes for radiationless decay of the charge transfer excited states of OsL/sub 3//sup 2+/3+/, and the 10/sup 5/ - 10/sup 6/ differences in lifetimes between MLCT states of OsL/sub 3//sup 2 +/ complexes and the LMCT states of OsL/sub 3//sup 3 +/ complexes is largely due to the difference in their energy gaps. 1 table.

  18. Research on biodeterioration of wood, 1987-1992. 1. Decay mechanisms and biocontrol. Forest Service research paper

    SciTech Connect

    Highley, T.L.; Clausen, C.A.; Croan, S.C.; Green, F.; Illman, B.L.

    1994-03-01

    Growing concerns about the environment present an urgent need for new approaches to preserving wood. Some commonly used preservatives have been banned or restricted in several countries. The research paper first describes current knowledge about how white-and-brown rot fungi decay wood and then delineates research in to problem areas: (1) control of wood decay through targeting biosynthetic and degradative pathways, and (2) biological control (biocontrol) of wood decay through non-decay micro-organisms.

  19. Reduced order modeling of mechanical degradation induced performance decay in lithium-ion battery porous electrodes

    DOE PAGES

    Barai, Pallab; Smith, Kandler; Chen, Chien -Fan; Kim, Gi -Heon; Mukherjee, Partha P.

    2015-06-17

    In this paper, a one-dimensional computational framework is developed that can solve for the evolution of voltage and current in a lithium-ion battery electrode under different operating conditions. A reduced order model is specifically constructed to predict the growth of mechanical degradation within the active particles of the carbon anode as a function of particle size and C-rate. Using an effective diffusivity relation, the impact of microcracks on the diffusivity of the active particles has been captured. Reduction in capacity due to formation of microcracks within the negative electrode under different operating conditions (constant current discharge and constant current constantmore » voltage charge) has been investigated. At the beginning of constant current discharge, mechanical damage to electrode particles predominantly occurs near the separator. As the reaction front shifts, mechanical damage spreads across the thickness of the negative electrode and becomes relatively uniform under multiple discharge/charge cycles. Mechanical degradation under different drive cycle conditions has been explored. It is observed that electrodes with larger particle sizes are prone to capacity fade due to microcrack formation. Finally, under drive cycle conditions, small particles close to the separator and large particles close to the current collector can help in reducing the capacity fade due to mechanical degradation.« less

  20. Reduced order modeling of mechanical degradation induced performance decay in lithium-ion battery porous electrodes

    SciTech Connect

    Barai, Pallab; Smith, Kandler; Chen, Chien -Fan; Kim, Gi -Heon; Mukherjee, Partha P.

    2015-06-17

    In this paper, a one-dimensional computational framework is developed that can solve for the evolution of voltage and current in a lithium-ion battery electrode under different operating conditions. A reduced order model is specifically constructed to predict the growth of mechanical degradation within the active particles of the carbon anode as a function of particle size and C-rate. Using an effective diffusivity relation, the impact of microcracks on the diffusivity of the active particles has been captured. Reduction in capacity due to formation of microcracks within the negative electrode under different operating conditions (constant current discharge and constant current constant voltage charge) has been investigated. At the beginning of constant current discharge, mechanical damage to electrode particles predominantly occurs near the separator. As the reaction front shifts, mechanical damage spreads across the thickness of the negative electrode and becomes relatively uniform under multiple discharge/charge cycles. Mechanical degradation under different drive cycle conditions has been explored. It is observed that electrodes with larger particle sizes are prone to capacity fade due to microcrack formation. Finally, under drive cycle conditions, small particles close to the separator and large particles close to the current collector can help in reducing the capacity fade due to mechanical degradation.

  1. Σ--antihyperon correlations in Z0 decay and investigation of the baryon production mechanism

    NASA Astrophysics Data System (ADS)

    Abbiendi, G.; Ainsley, C.; Åkesson, P. F.; Alexander, G.; Anagnostou, G.; Anderson, K. J.; Asai, S.; Axen, D.; Bailey, I.; Barberio, E.; Barillari, T.; Barlow, R. J.; Batley, R. J.; Bechtle, P.; Behnke, T.; Bell, K. W.; Bell, P. J.; Bella, G.; Bellerive, A.; Benelli, G.; Bethke, S.; Biebel, O.; Boeriu, O.; Bock, P.; Boutemeur, M.; Braibant, S.; Brown, R. M.; Burckhart, H. J.; Campana, S.; Capiluppi, P.; Carnegie, R. K.; Carter, A. A.; Carter, J. R.; Chang, C. Y.; Charlton, D. G.; Ciocca, C.; Csilling, A.; Cuffiani, M.; Dado, S.; Dallavalle, M.; de Roeck, A.; de Wolf, E. A.; Desch, K.; Dienes, B.; Dubbert, J.; Duchovni, E.; Duckeck, G.; Duerdoth, I. P.; Etzion, E.; Fabbri, F.; Ferrari, P.; Fiedler, F.; Fleck, I.; Ford, M.; Frey, A.; Gagnon, P.; Gary, J. W.; Geich-Gimbel, C.; Giacomelli, G.; Giacomelli, P.; Giunta, M.; Goldberg, J.; Gross, E.; Grunhaus, J.; Gruwé, M.; Gupta, A.; Hajdu, C.; Hamann, M.; Hanson, G. G.; Harel, A.; Hauschild, M.; Hawkes, C. M.; Hawkings, R.; Herten, G.; Heuer, R. D.; Hill, J. C.; Horváth, D.; Igo-Kemenes, P.; Ishii, K.; Jeremie, H.; Jovanovic, P.; Junk, T. R.; Kanzaki, J.; Karlen, D.; Kawagoe, K.; Kawamoto, T.; Keeler, R. K.; Kellogg, R. G.; Kennedy, B. W.; Kluth, S.; Kobayashi, T.; Kobel, M.; Komamiya, S.; Krämer, T.; Krasznahorkay, A.; Krieger, P.; von Krogh, J.; Kuhl, T.; Kupper, M.; Lafferty, G. D.; Landsman, H.; Lanske, D.; Lellouch, D.; Letts, J.; Levinson, L.; Lillich, J.; Lloyd, S. L.; Loebinger, F. K.; Lu, J.; Ludwig, A.; Ludwig, J.; Mader, W.; Marcellini, S.; Martin, A. J.; Mashimo, T.; Mättig, P.; McKenna, J.; McPherson, R. A.; Meijers, F.; Menges, W.; Merritt, F. S.; Mes, H.; Meyer, N.; Michelini, A.; Mihara, S.; Mikenberg, G.; Miller, D. J.; Mohr, W.; Mori, T.; Mutter, A.; Nagai, K.; Nakamura, I.; Nanjo, H.; Neal, H. A.; O'Neale, S. W.; Oh, A.; Oreglia, M. J.; Orito, S.; Pahl, C.; Pásztor, G.; Pater, J. R.; Pilcher, J. E.; Pinfold, J.; Plane, D. E.; Pooth, O.; Przybycień, M.; Quadt, A.; Rabbertz, K.; Rembser, C.; Renkel, P.; Roney, J. M.; Rossi, A. M.; Rozen, Y.; Runge, K.; Sachs, K.; Saeki, T.; Sarkisyan, E. K. G.; Schaile, A. D.; Schaile, O.; Scharff-Hansen, P.; Schieck, J.; Schörner-Sadenius, T.; Schröder, M.; Schumacher, M.; Seuster, R.; Shears, T. G.; Shen, B. C.; Sherwood, P.; Skuja, A.; Smith, A. M.; Sobie, R.; Söldner-Rembold, S.; Spano, F.; Stahl, A.; Strom, D.; Ströhmer, R.; Tarem, S.; Tasevsky, M.; Teuscher, R.; Thomson, M. A.; Torrence, E.; Toya, D.; Trigger, I.; Trócsányi, Z.; Tsur, E.; Turner-Watson, M. F.; Ueda, I.; Ujvári, B.; Vollmer, C. F.; Vannerem, P.; Vértesi, R.; Verzocchi, M.; Voss, H.; Vossebeld, J.; Ward, C. P.; Ward, D. R.; Watkins, P. M.; Watson, A. T.; Watson, N. K.; Wells, P. S.; Wengler, T.; Wermes, N.; Wetterling, D.; Wilson, G. W.; Wilson, J. A.; Wolf, G.; Wyatt, T. R.; Yamashita, S.; Zer-Zion, D.; Zivkovic, L.

    2009-12-01

    Data collected around sqrt{s}=91 GeV by the OPAL experiment at the LEP e+e- collider are used to study the mechanism of baryon formation. As the signature, the fraction of Σ- hyperons whose baryon number is compensated by the production of a overline{Σ-},overline{Λ} or overline{Ξ-} antihyperon is determined. The method relies entirely on quantum number correlations of the baryons, and not rapidity correlations, making it more model independent than previous studies. Within the context of the JETSET implementation of the string hadronization model, the diquark baryon production model without the popcorn mechanism is strongly disfavored with a significance of 3.8 standard deviations including systematic uncertainties. It is shown that previous studies of the popcorn mechanism with Λ overline{Λ} and p\\uppi overline{p} correlations are not conclusive, if parameter uncertainties are considered.

  2. New production mechanism for keV sterile neutrino Dark Matter by decays of frozen-in scalars

    SciTech Connect

    Merle, Alexander; Niro, Viviana; Schmidt, Daniel E-mail: niro@ecm.ub.edu

    2014-03-01

    We propose a new production mechanism for keV sterile neutrino Dark Matter. In our setting, we assume the existence of a scalar singlet particle which never entered thermal equilibrium in the early Universe, since it only couples to the Standard Model fields by a really small Higgs portal interaction. For suitable values of this coupling, the scalar can undergo the so-called freeze-in process, and in this way be efficiently produced in the early Universe. These scalars can then decay into keV sterile neutrinos and produce the correct Dark Matter abundance. While similar settings in which the scalar does enter thermal equilibrium and then freezes out have been studied previously, the mechanism proposed here is new and represents a versatile extension of the known case. We perform a detailed numerical calculation of the DM production using a set of coupled Boltzmann equations, and we illustrate the successful regions in the parameter space. Our production mechanism notably can even work in models where active-sterile mixing is completely absent.

  3. Localizing gene regulation reveals a staggered wood decay mechanism for the brown rot fungus Postia placenta

    PubMed Central

    Zhang, Jiwei; Presley, Gerald N.; Ryu, Jae-San; Menke, Jon R.; Figueroa, Melania; Orr, Galya; Schilling, Jonathan S.

    2016-01-01

    Wood-degrading brown rot fungi are essential recyclers of plant biomass in forest ecosystems. Their efficient cellulolytic systems, which have potential biotechnological applications, apparently depend on a combination of two mechanisms: lignocellulose oxidation (LOX) by reactive oxygen species (ROS) and polysaccharide hydrolysis by a limited set of glycoside hydrolases (GHs). Given that ROS are strongly oxidizing and nonselective, these two steps are likely segregated. A common hypothesis has been that brown rot fungi use a concentration gradient of chelated metal ions to confine ROS generation inside wood cell walls before enzymes can infiltrate. We examined an alternative: that LOX components involved in ROS production are differentially expressed by brown rot fungi ahead of GH components. We used spatial mapping to resolve a temporal sequence in Postia placenta, sectioning thin wood wafers colonized directionally. Among sections, we measured gene expression by whole-transcriptome shotgun sequencing (RNA-seq) and assayed relevant enzyme activities. We found a marked pattern of LOX up-regulation in a narrow (5-mm, 48-h) zone at the hyphal front, which included many genes likely involved in ROS generation. Up-regulation of GH5 endoglucanases and many other GHs clearly occurred later, behind the hyphal front, with the notable exceptions of two likely expansins and a GH28 pectinase. Our results support a staggered mechanism for brown rot that is controlled by differential expression rather than microenvironmental gradients. This mechanism likely results in an oxidative pretreatment of lignocellulose, possibly facilitated by expansin- and pectinase-assisted cell wall swelling, before cellulases and hemicellulases are deployed for polysaccharide depolymerization. PMID:27621450

  4. Localizing gene regulation reveals a staggered wood decay mechanism for the brown rot fungus Postia placenta.

    PubMed

    Zhang, Jiwei; Presley, Gerald N; Hammel, Kenneth E; Ryu, Jae-San; Menke, Jon R; Figueroa, Melania; Hu, Dehong; Orr, Galya; Schilling, Jonathan S

    2016-09-27

    Wood-degrading brown rot fungi are essential recyclers of plant biomass in forest ecosystems. Their efficient cellulolytic systems, which have potential biotechnological applications, apparently depend on a combination of two mechanisms: lignocellulose oxidation (LOX) by reactive oxygen species (ROS) and polysaccharide hydrolysis by a limited set of glycoside hydrolases (GHs). Given that ROS are strongly oxidizing and nonselective, these two steps are likely segregated. A common hypothesis has been that brown rot fungi use a concentration gradient of chelated metal ions to confine ROS generation inside wood cell walls before enzymes can infiltrate. We examined an alternative: that LOX components involved in ROS production are differentially expressed by brown rot fungi ahead of GH components. We used spatial mapping to resolve a temporal sequence in Postia placenta, sectioning thin wood wafers colonized directionally. Among sections, we measured gene expression by whole-transcriptome shotgun sequencing (RNA-seq) and assayed relevant enzyme activities. We found a marked pattern of LOX up-regulation in a narrow (5-mm, 48-h) zone at the hyphal front, which included many genes likely involved in ROS generation. Up-regulation of GH5 endoglucanases and many other GHs clearly occurred later, behind the hyphal front, with the notable exceptions of two likely expansins and a GH28 pectinase. Our results support a staggered mechanism for brown rot that is controlled by differential expression rather than microenvironmental gradients. This mechanism likely results in an oxidative pretreatment of lignocellulose, possibly facilitated by expansin- and pectinase-assisted cell wall swelling, before cellulases and hemicellulases are deployed for polysaccharide depolymerization. PMID:27621450

  5. Study of Decay Mechanisms in B-→Λc+p¯π- Decays and Observation of Low-Mass Structure in the Λc+p¯ System

    NASA Astrophysics Data System (ADS)

    Gabyshev, N.; Abe, K.; Abe, K.; Adachi, I.; Aihara, H.; Asano, Y.; Aulchenko, V.; Aushev, T.; Bakich, A. M.; Bitenc, U.; Bizjak, I.; Blyth, S.; Bondar, A.; Bozek, A.; Bračko, M.; Brodzicka, J.; Browder, T. E.; Chang, P.; Chao, Y.; Chen, A.; Chen, W. T.; Cheon, B. G.; Chistov, R.; Choi, S.-K.; Choi, Y.; Chuvikov, A.; Cole, S.; Dalseno, J.; Danilov, M.; Dash, M.; Drutskoy, A.; Eidelman, S.; Enari, Y.; Fratina, S.; Gershon, T.; Gokhroo, G.; Golob, B.; Gorišek, A.; Hara, T.; Hayashii, H.; Hazumi, M.; Hokuue, T.; Hoshi, Y.; Hou, S.; Hou, W.-S.; Hsiung, Y. B.; Iijima, T.; Imoto, A.; Inami, K.; Ishikawa, A.; Itoh, R.; Iwasaki, M.; Iwasaki, Y.; Kang, J. H.; Kang, J. S.; Kataoka, S. U.; Katayama, N.; Kawai, H.; Kawasaki, T.; Khan, H. R.; Kichimi, H.; Kim, H. J.; Kim, H. O.; Kim, S. K.; Kim, S. M.; Kinoshita, K.; Korpar, S.; Krokovny, P.; Kumar, S.; Kuo, C. C.; Kuzmin, A.; Kwon, Y.-J.; Lange, J. S.; Leder, G.; Lesiak, T.; Lin, S.-W.; Mandl, F.; Matsumoto, T.; Mikami, Y.; Mitaroff, W.; Miyake, H.; Miyata, H.; Mizuk, R.; Nagamine, T.; Nagasaka, Y.; Nakano, E.; Nakao, M.; Nakazawa, H.; Natkaniec, Z.; Nishida, S.; Nitoh, O.; Ogawa, S.; Ohshima, T.; Okabe, T.; Okuno, S.; Olsen, S. L.; Onuki, Y.; Ozaki, H.; Palka, H.; Park, C. W.; Park, H.; Parslow, N.; Peak, L. S.; Pestotnik, R.; Piilonen, L. E.; Rozanska, M.; Sagawa, H.; Sakai, Y.; Sato, N.; Schietinger, T.; Schneider, O.; Schwartz, A. J.; Senyo, K.; Seuster, R.; Sevior, M. E.; Shibuya, H.; Sidorov, V.; Singh, J. B.; Somov, A.; Stamen, R.; Stanič, S.; Starič, M.; Sumiyoshi, T.; Suzuki, S. Y.; Tajima, O.; Takasaki, F.; Tamai, K.; Tamura, N.; Tanaka, M.; Teramoto, Y.; Tian, X. C.; Tsuboyama, T.; Tsukamoto, T.; Uehara, S.; Uglov, T.; Ueno, K.; Uno, S.; Urquijo, P.; Varner, G.; Varvell, K. E.; Villa, S.; Wang, C. H.; Wang, M.-Z.; Xie, Q. L.; Yabsley, B. D.; Yamaguchi, A.; Yamamoto, H.; Yamashita, Y.; Yamauchi, M.; Yang, Heyoung; Zhang, C. C.; Zhang, J.; Zhang, L. M.; Zhang, Z. P.; Zhilich, V.; Žontar, D.

    2006-12-01

    Using a sample of 152×106 BB¯ pairs accumulated with the Belle detector at the KEKB e+e- collider, we study the decay mechanism of three-body charmed decay B-→Λc+p¯π-. The intermediate two-body decay B-→Σc(2455)0p¯ is observed for the first time with a branching fraction of (3.7±0.7±0.4±1.0)×10-5 and a statistical significance of 8.4σ. We also observe a low-mass enhancement in the (Λc+p¯) system, which can be parametrized as a Breit-Wigner function with a mass of (3.35-0.02+0.01±0.02)GeV/c2 and a width of (0.07-0.03+0.04±0.04)GeV/c2. We measure its branching fraction to be (3.9-0.7+0.8±0.4±1.0)×10-5 with a statistical significance of 6.2σ. The errors are statistical, systematic, and that of the Λc+→pK-π+ decay branching fraction.

  6. Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion

    SciTech Connect

    Martinez, Diego; Challacombe, Jean; Morgenstern, Ingo; Hibbett, David; Schmoll, Monika; Kubicek, Christian P.; Ferreira, Patricia; Ruiz-Duenas, Francisco; Martinez, Angel T.; Kersten, Phil; Hammel, Ken; Vanden Wymelenberg, Amber; Gaskell, Jill; Lindquist, Erika; Sabat, Gregorz; Splinter Bondurant, Sandra; Larrondo, Luis F.; Canessa, Paulo; Vicuna, Rafael; Yadev, Jagjit; Doddapaneni, Harshavardhan; Subramanian, Venkataramanan; Pisabarro, Antonio; Lavin, Jose L.; Oguiza, Jose A.; Master, Emma; Henrissat, Bernard; Coutinho, Pedro M.; Harris, Paul; Magnuson, Jon K.; Baker, Scott E.; Bruno, Kenneth S.; Kenealy, William; Hoegger, Patrik; Kues, Ursula; Ramaiya, Preethi; Lucas, Susan; Salamov, Asaf; Shapiro, Harris; Tu, Hank; Chee, Christine L.; Misra, Monica; Xie, Gary; Teter, Sarah; Yaver, Debbie; James, Tim; Mokrejs, Martin; Pospisek, Martin; Grigoriev, Igor V.; Brettin, T.; Rokhsar, Daniel S.; Berka, Randy; Cullen, Dan

    2009-02-10

    Brown-rot fungi such as Postia placenta are common inhabitants of forest ecosystems and are also largely responsible for the destructive decay of wooden structures. Rapid depolymerization of cellulose is a distinguishing feature of brown-rot, but the biochemical mechanisms and underlying genetics are poorly understood. Systematic examination of the P. placenta genome, transcriptome, and secretome revealed unique extracellular enzyme systems, including an unusual repertoire of extracellular glycoside hydrolases. Genes encoding exocellobiohydrolases and cellulose-binding domains, typical of cellulolytic microbes, are absent in this efficient cellulose-degrading fungus. When P. placenta was grown in media containing cellulose as sole carbon source, transcripts corresponding to many hemicellulases and to a single putative β-1-4 endoglucanase were expressed at high levels relative to glucose grown cultures. These transcript profiles were confirmed by direct identification of peptides by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Also upregulated under cellulolytic culture conditions were putative iron reductases, quinone reductase, and structurally divergent oxidases potentially involved in extracellular generation of Fe(II) and H2O2. These observations are consistent with a biodegradative role for Fenton chemistry in which Fe(II) and H2O2 react to form hydroxyl radicals, highly reactive oxidants capable of depolymerizing cellulose. The P. placenta genome resources provide unparalleled opportunities for investigating such unusual mechanisms of cellulose conversion. More broadly, the genome offers insight into the diversification of lignocellulose degrading mechanisms in fungi. In particular, comparisons between P. placenta and the closely related white-rot fungus, Phanerochaete chrysosporium support an evolutionary shift from white-rot to brown-rot during which efficient depolymerization of lignin was lost.

  7. Genome, transcriptome, and secretome analysis of wood decay fungus postia placenta supports unique mechanisms of lignocellulose conversion

    SciTech Connect

    Martinez, Diego; Challacombe, Jean F; Misra, Monica; Xie, Gary; Brettin, Thomas; Morgenstern, Ingo; Hibbett, David; Schmoll, Monika; Kubicek, Christian P; Ferreira, Patricia; Ruiz - Duenase, Francisco J; Martinez, Angel T; Kersten, Phil; Hammel, Kenneth E; Vanden Wymelenberg, Amber; Gaskell, Jill; Lindquist, Erika; Sabati, Grzegorz; Bondurant, Sandra S; Larrondo, Luis F; Canessa, Paulo; Vicunna, Rafael; Yadavk, Jagiit; Doddapaneni, Harshavardhan; Subramaniank, Venkataramanan; Pisabarro, Antonio G; Lavin, Jose L; Oguiza, Jose A; Master, Emma; Henrissat, Bernard; Coutinho, Pedro M; Harris, Paul; Magnuson, Jon K; Baker, Scott; Bruno, Kenneth; Kenealy, William; Hoegger, Patrik J; Kues, Ursula; Ramaiva, Preethi; Lucas, Susan; Salamov, Asaf; Shapiro, Harris; Tuh, Hank; Chee, Christine L; Teter, Sarah; Yaver, Debbie; James, Tim; Mokrejs, Martin; Pospisek, Martin; Grigoriev, Igor; Rokhsar, Dan; Berka, Randy; Cullen, Dan

    2008-01-01

    Brown-rot fungi such as Postia placenta are common inhabitants of forest ecosystems and are also largely responsible for the destructive decay of wooden structures. Rapid depolymerization of cellulose is a distinguishing feature of brown-rot, but the biochemical mechanisms and underlying genetics are poorly understood. Systematic examination of the P. placenta genome, transcriptome and secretome revealed unique extracellular enzyme systems, including an unusual repertoire of extracellular glycoside hydrolases. Genes encoding exocellobiohydrolases and cellulose-binding domains, typical of cellulolytic microbes, are absent in this efficient cellulose-degrading fungus. When P. placenta was grown in medium containing cellulose as sole carbon source, transcripts corresponding to many hemicellulases and to a single putative {beta}-1-4 endoglucanase were expressed at high levels relative to glucose grown cultures. These transcript profiles were confirmed by direct identification of peptides by liquid chromatography-tandem mass spectrometry (LC{center_dot}MSIMS). Also upregulated during growth on cellulose medium were putative iron reductases, quinone reductase, and structurally divergent oxidases potentially involved in extracellular generation of Fe(II) and H202. These observations are consistent with a biodegradative role for Fenton chemistry in which Fe(II) and H202 react to form hydroxyl radicals, highly reactive oxidants capable of depolymerizing cellulose. The P. placenta genome resources provide unparalleled opportunities for investigating such unusual mechanisms of cellulose conversion. More broadly, the genome offers insight into the diversification of lignocellulose degrading mechanisms in fungi. Comparisons to the closely related white-rot fungus Phanerochaete chrysosporium support an evolutionary shift from white-rot to brown-rot during which the capacity for efficient depolymerization of lignin was lost.

  8. Is the X (3915 ) the χc 0(2 P )?

    NASA Astrophysics Data System (ADS)

    Olsen, Stephen Lars

    2015-03-01

    The Particle Data Group Meson Summary Table lists the X (3915 ) meson, an ω J /ψ mass peak seen in B →K ω J /ψ decays and γ γ →ω J /ψ two-photon fusion reactions, as the χc 0(2 P ), the 23P0 charmonium state. Here, with some reasonable assumptions, it is shown that if the X (3915 ) is the χc 0(2 P ), the measured strength of the γ γ →X (3915 ) signal implies an upper limit on the branching fraction B (χc 0(2 P )→ω J /ψ ) that is below a lower limit inferred for the same quantity from the B →K X (3915 ) decay rate. Also, the absence any signal for X (3915 )→D0D¯0 in B+→K+D0D¯0 decays is used to infer the limit B (X (3915 )→D0D¯0)<1.2 ×B (X (3915 )→ω J /ψ ). This contradicts expectations that χc 0(2 P ) decays to D0D¯0 should be a dominant process, while decays to ω J /ψ , which are Okubo-Zweig-Iizuka suppressed, should be relatively rare. These, plus reasons given earlier by Guo and Meissner, raise concerns about the X (3915 )=χc 0(2 P ) assignment.

  9. Identification of lysines within membrane-anchored Mga2p120 that are targets of Rsp5p ubiquitination and mediate mobilization of tethered Mga2p90

    PubMed Central

    Bhattacharya, Sabyasachi; Shcherbik, Natalia; Vasilescu, Julian; Smith, Jeffrey C.; Figeys, Daniel; Haines, Dale S.

    2009-01-01

    Summary Mga2p90 is an endoplasmic reticulum (ER) localized transcription factor that is released from the ER membrane by a unique ubiquitin-dependent mechanism. Mga2p90 mobilization requires poly-ubiquitination of its associating membrane-bound Mga2p120 anchor and subsequent Mga2p120-Mga2p90 complex disassembly that is mediated by ATPase Cdc48p and its heteromeric ubiquitin-binding adaptor Npl4p-Ufd1p. Although previous studies have identified the ubiquitin ligase (i.e. Rsp5p) and ligase binding site on Mga2p120 that play a role in this process, the amino acids of Mga2p120 that are targets of ubiquitination and promote Mga2p90 mobilization are unknown. We have identified using mass spectrometry analysis of in vitro ubiquitinated Mga2p120-Mga2p90 complex that lysines 983 and 985 contained within the carboxy-terminal domain of Mga2p120 are Rsp5p-directed ubiquitin conjugation sites. Mutation of these residues as well as proximally located lysine 980 results in suppression of Mga2p120 ubiquitination in vitro and in vivo, inefficient liberation of Mga2p90 by Cdc48pNpl4p/Ufd1p in vitro, and ER retention of Mga2p in cells. Moreover, mga2Δ/spt23ts harboring Rsp5p binding and conjugation mga2 mutants express low OLE1 (an Mga2p90 target gene) transcripts and display reduced growth. We conclude that residues 980, 983 and 985 are targets of Rsp5p-induced poly-ubiquitination and mediate Cdc48pNpl4p/Ufd1p-dependent Mga2p90-Mga2p120 separation and Mga2p90 mobilization. PMID:19061897

  10. E6 Gamma Decay

    SciTech Connect

    Brown, B. Alex; Rae, W. D. M.

    2011-05-06

    Rare electric hexacontatetrapole (E6) transitions are studied in the full (f{sub 7/2},f{sub 5/2},p{sub 3/2},p{sub 1/2}) shell-model basis. Comparison of theory to the results from the gamma decay in {sup 53}Fe and from inelastic electron scattering on {sup 52}Cr provides unique and interesting tests of the valence wavefunctions, the models used for energy density functionals and into the origin of effective charge.

  11. Tooth Decay

    MedlinePlus

    ... in your mouth made up mostly of germs. Tooth decay starts in the outer layer, called the enamel. Without a filling, the decay can get deep into the tooth and its nerves and cause a toothache or ...

  12. Equivalence between the mechanical model and energy-transfer theory for the classical decay rates of molecules near a spherical particle.

    PubMed

    Chung, H Y; Leung, P T; Tsai, D P

    2012-05-14

    In the classical modeling of decay rates for molecules interacting with a nontrivial environment, it is well known that two alternate approaches exist which include: (1) a mechanical model treating the system as a damped harmonic oscillator driven by the reflected fields from the environment; and (2) a model based on the radiative and nonradiative energy transfers from the excited molecular system to the environment. While the exact equivalence of the two methods is not trivial and has been explicitly demonstrated only for planar geometry, it has been widely taken for granted and applied to other geometries such as in the interaction of the molecule with a spherical particle. Here we provide a rigorous proof of such equivalence for the molecule-sphere problem via a direct calculation of the decay rates adopting each of the two different approaches.

  13. The mechanism of {beta}-delayed two-proton emission in {sup 31}Ar

    SciTech Connect

    Borge, M. J. G.; Fraile, L. M.; Axelsson, L.; Jonson, B.; Nilsson, T.; Nyman, G.; Smedberg, M. H.; Aeystoe, J.; Jokinen, A.; Fynbo, H. O. U.; Hornshoej, P.; Mukha, I.; Petersen, B.; Riisager, K.; Honkanen, A.; Oinonen, M.; Martel, I.; Tengblad, O.

    1998-12-21

    Beta-delayed two-proton decays, observed in several nuclei along the proton dripline, have only been studied in detail in very few cases. We have studied the decay of {sup 31}Ar, as it was suspected that this nucleus has several {beta}-2p branches with quite large branching ratios. We report here on two experiments done at ISOLDE-PSB (CERN) yielding to the most extensive investigation done so far on a {beta}-delayed two-proton emitter. The analysis of the data have allow us to identify four {beta}-2p branches connecting the IAS with ground and excited states in the two proton daughter {sup 29}P. About ten {beta}-2p peaks have been assigned to decays from excited states in {sup 31}Cl at lower excitation energies than the IAS. In view of the energy and angular distribution of the individual protons the 2p-decay mechanisms are determined.

  14. Upregulation of Nicotinic Acetylcholine Receptor alph4+beta2 through a Ligand-Independent PI3Kbeta Mechanism That Is Enhanced by TNFalpha and the Jak2/p38Mapk Pathways

    PubMed Central

    Rogers, Scott W.; Gahring, Lorise C.

    2015-01-01

    High affinity nicotine-binding sites in the mammalian brain are neuronal nicotinic acetylcholine receptors (nAChR) assembled from at least alpha4 and beta2 subunits into pentameric ion channels. When exposed to ligands such as nicotine, these receptors respond by undergoing upregulation, a correlate of nicotine addiction. Upregulation can be measured using HEK293 (293) cells that stably express alpha4 and beta2 subunits using quantification of [3H]epibatidine ([3H]Eb) binding to measure mature receptors. Treatment of these cells with choline also produces upregulation through a hemicholinium3 (HC3)-sensitive (choline kinase) and an HC3-insensitive pathway which are both independent of the mechanism used by nicotine for upregulation. In both cases, upregulation is significantly enhanced by the pro-inflammatory cytokine tumor necrosis factor alpha (TNFα) which signals through its receptor Tnfr1 to activate p38Mapk. Here we report that the inhibition of class1 phosphoinositide 3-kinases isoform PI3Kbeta using the selective antagonist PI828 is alone sufficient to produce upregulation and enhance both nicotine and choline HC3-sensitive mediated upregulation. Further, these processes are impacted upon by an AG-490 sensitive Jak2-associated pathway. Both PI3Kbeta (negative) and Jak2 (positive) modulation of upregulation converge through p38Mapk and both overlap with TNFalpha enhancement of this process. Upregulation through the PI3Kbeta pathway did not require Akt. Collectively these findings support upregulation of endogenous alpha4beta2 as a balance among cellular signaling networks that are highly responsive to multiple environmental, inflammatory and metabolic agents. The findings also suggest how illness and metabolic stress could alter the expression of this important nicotinic receptor and novel avenues to intercede in modifying its expression. PMID:26619345

  15. General decay rates for the wave equation with mixed-type damping mechanisms on unbounded domain with finite measure

    NASA Astrophysics Data System (ADS)

    Dias Silva, Flávio R.; Nascimento, Flávio A. F.; Rodrigues, José H.

    2015-12-01

    This paper is concerned with the study of the uniform decay rates of the energy associated with the wave equation subject to a locally distributed viscoelastic dissipation and a nonlinear frictional damping u_{tt}- Δ u+ int_0^t g(t-s)div[a(x)nabla u(s)] ds + b(x) f(u_t)=0 quad on quad Ω×]0,infty[, where {Ωsubset{R}^n, n≥ 2} is an unbounded open set with finite measure and unbounded smooth boundary {partialΩ = Γ}. Supposing that the localization functions satisfy the "competitive" assumption {a(x)+b(x)≥δ>0} for all {xin Ω} and the relaxation function g satisfies certain nonlinear differential inequalities introduced by Lasiecka et al. (J Math Phys 54(3):031504, 2013), we extend to our considered domain the prior results of Cavalcanti and Oquendo (SIAM J Control Optim 42(4):1310-1324, 2003). In addition, while in Cavalcanti and Oquendo (2003) the authors just consider exponential and polynomial decay rate estimates, in the present article general decay rate estimates are obtained.

  16. DNA Compaction by Yeast Mitochondrial Protein ABF2p

    SciTech Connect

    Friddle, R W; Klare, J E; Noy, A; Corzett, M; Balhorn, R; Baskin, R J; Martin, S S; Baldwin, E P

    2003-05-09

    We used high resolution Atomic Force Microscopy (AFM) to image compaction of linear and circular DNA by the yeast mitochondrial protein ABF2p , which plays a major role in maintaining mitochondrial DNA. AFM images show that protein binding induces drastic bends in the DNA backbone for both linear and circular DNA. At high concentration of ABF2p DNA collapses into a tight globular structure. We quantified the compaction of linear DNA by measuring the end-to-end distance of the DNA molecule at increasing concentrations of ABF2p. We also derived a polymer statistical mechanics model that gives quantitative description of compaction observed in our experiments. This model shows that a number of sharp bends in the DNA backbone is often sufficient to cause DNA compaction. Comparison of our model with the experimental data showed excellent quantitative correlation and allowed us to determine binding characteristics for ABF2. Our studies indicate that ABF2 compacts DNA through a novel mechanism that involves bending of DNA backbone. We discuss the implications of such a mechanism for mitochondrial DNA maintenance.

  17. Data Sharing in P2P Systems

    NASA Astrophysics Data System (ADS)

    Hayek, Rabab; Raschia, Guillaume; Valduriez, Patrick; Mouaddib, Noureddine

    In this chapter, we survey P2P data sharing systems. All along, we focus on the evolution from simple file-sharing systems, with limited functionalities, to Peer Data Management Systems (PDMS) that support advanced applications with more sophisticated data management techniques. Advanced P2P applications are dealing with semantically rich data (e.g., XML documents, relational tables), using a high-level SQL-like query language. We start our survey with an overview over the existing P2P network architectures, and the associated routing protocols. Then, we discuss data indexing techniques based on their distribution degree and the semantics they can capture from the underlying data. We also discuss schema management techniques which allow integrating heterogeneous data. We conclude by discussing the techniques proposed for processing complex queries (e.g., range and join queries). Complex query facilities are necessary for advanced applications which require a high level of search expressiveness. This last part shows the lack of querying techniques that allow for an approximate query answering.

  18. Radioactive decay.

    PubMed

    Groch, M W

    1998-01-01

    When a parent radionuclide decays to its daughter radionuclide by means of alpha, beta, or isomeric transition, the decay follows an exponential form, which is characterized by the decay constant lambda. The decay constant represents the probability per unit time that a single radioatom will decay. The decay equation can be used to provide a useful expression for radionuclide decay, the half-life, the time when 50% of the radioatoms present will have decayed. Radiotracer half-life has direct implications in nuclear imaging, radiation therapy, and radiation safety because radionuclide half-life affects the ability to evaluate tracer kinetics and create appropriate nuclear images and also affects organ, tumor, and whole-body radiation dose. The number of radioatoms present in a sample is equal to the activity, defined as the number of transitions per unit time, divided by the decay constant; the mass of radioatoms present in a sample can be calculated to determine the specific activity (activity per unit mass). The dynamic relationship between the number of parent and daughter atoms present over time may lead to radioactive equilibrium, which takes two forms--secular and transient--and has direct relevance to generator-produced radionuclides.

  19. Kinetics of the Reactions of F((sup 2)P) and Cl((sup 2)P) with HNO3

    NASA Technical Reports Server (NTRS)

    Wine, P. H.; Wells, J. R.; Nicovich, J. M.

    1997-01-01

    The kinetics of the reactions of HNO3 with fluorine (k(sub 1)) and Chlorine (k(sub 2)) atoms have been studied by using a time-resolved long-path laser absorption technique to monitor the appearance of product NO3 radicals following 351-nm pulsed laser photolysis of X2/HNO3/He mixtures (X = F,Cl). Absolute rate coefficients for the F((sup 2)P) + HNO reaction have been determined over the temperature range 260-373 K. Between 260 and 320 K, the data are adequately represented by the Arrhenius expression k(sub 1)(T) = (6.0 +/- 2.6) x 10(exp -12) exp[(40 +/- 120)/T]cu cm/(molecule.s). Between 335 and 373 K, the rate coefficient is found to be (2.0 +/- 0.3) x 10(exp -11)cu cm/(molecule.s) independent of temperature. The observed temperature dependence suggests that reaction proceeds via competing direct abstraction and complex pathways. No NO3 production was observed in the experiments with X equals Cl, thus establishing that k(sub 2)(298 K) is less than 2 x 10(exp -16) cu cm/(molecule.s). The Cl((sup 2)P) + HNO reaction was also investigated by using a pulsed laser photolysis-resonance fluorescence technique to monitor the decay of Cl((sup 2)P). Upper limit values for k(sub 2) obtained from these experiments, in units of 10(exp -16)cu cm/(molecule.s), are 13 at 298 K and 10 at 400 K.

  20. Hypernuclear Weak Decays

    NASA Astrophysics Data System (ADS)

    Itonaga, K.; Motoba, T.

    The recent theoretical studies of Lambda-hypernuclear weak decaysof the nonmesonic and pi-mesonic ones are developed with the aim to disclose the link between the experimental decay observables and the underlying basic weak decay interactions and the weak decay mechanisms. The expressions of the nonmesonic decay rates Gamma_{nm} and the decay asymmetry parameter alpha_1 of protons from the polarized hypernuclei are presented in the shell model framework. We then introduce the meson theoretical Lambda N -> NN interactions which include the one-meson exchanges, the correlated-2pi exchanges, and the chiral-pair-meson exchanges. The features of meson exchange potentials and their roles on the nonmesonic decays are discussed. With the adoption of the pi + 2pi/rho + 2pi/sigma + omega + K + rhopi/a_1 + sigmapi/a_1 exchange potentials, we have carried out the systematic calculations of the nonmesonic decay observables for light-to-heavy hypernuclei. The present model can account for the available experimental data of the decay rates, Gamma_n/Gamma_p ratios, and the intrinsic asymmetry parameters alpha_Lambda (alpha_Lambda is related to alpha_1) of emitted protons well and consistently within the error bars. The hypernuclear lifetimes are evaluated by converting the total weak decay rates Gamma_{tot} = Gamma_pi + Gamma_{nm} to tau, which exhibit saturation property for the hypernuclear mass A ≥ 30 and agree grossly well with experimental data for the mass range from light to heavy hypernuclei except for the very light ones. Future extensions of the model and the remaining problems are also mentioned. The pi-mesonic weak processes are briefly surveyed, and the calculations and predictions are compared and confirmed by the recent high precision FINUDA pi-mesonic decay data. This shows that the theoretical basis seems to be firmly grounded.

  1. Multiple Decay Mechanisms and 2D-UV Spectroscopic Fingerprints of Singlet Excited Solvated Adenine-Uracil Monophosphate.

    PubMed

    Li, Quansong; Giussani, Angelo; Segarra-Martí, Javier; Nenov, Artur; Rivalta, Ivan; Voityuk, Alexander A; Mukamel, Shaul; Roca-Sanjuán, Daniel; Garavelli, Marco; Blancafort, Lluís

    2016-05-23

    The decay channels of singlet excited adenine uracil monophosphate (ApU) in water are studied with CASPT2//CASSCF:MM potential energy calculations and simulation of the 2D-UV spectroscopic fingerprints with the aim of elucidating the role of the different electronic states of the stacked conformer in the excited state dynamics. The adenine (1) La state can decay without a barrier to a conical intersection with the ground state. In contrast, the adenine (1) Lb and uracil S(U) states have minima that are separated from the intersections by sizeable barriers. Depending on the backbone conformation, the CT state can undergo inter-base hydrogen transfer and decay to the ground state through a conical intersection, or it can yield a long-lived minimum stabilized by a hydrogen bond between the two ribose rings. This suggests that the (1) Lb , S(U) and CT states of the stacked conformer may all contribute to the experimental lifetimes of 18 and 240 ps. We have also simulated the time evolution of the 2D-UV spectra and provide the specific fingerprint of each species in a recommended probe window between 25 000 and 38 000 cm(-1) in which decongested, clearly distinguishable spectra can be obtained. This is expected to allow the mechanistic scenarios to be discerned in the near future with the help of the corresponding experiments. Our results reveal the complexity of the photophysics of the relatively small ApU system, and the potential of 2D-UV spectroscopy to disentangle the photophysics of multichromophoric systems. PMID:27113273

  2. Multiple Decay Mechanisms and 2D-UV Spectroscopic Fingerprints of Singlet Excited Solvated Adenine-Uracil Monophosphate.

    PubMed

    Li, Quansong; Giussani, Angelo; Segarra-Martí, Javier; Nenov, Artur; Rivalta, Ivan; Voityuk, Alexander A; Mukamel, Shaul; Roca-Sanjuán, Daniel; Garavelli, Marco; Blancafort, Lluís

    2016-05-23

    The decay channels of singlet excited adenine uracil monophosphate (ApU) in water are studied with CASPT2//CASSCF:MM potential energy calculations and simulation of the 2D-UV spectroscopic fingerprints with the aim of elucidating the role of the different electronic states of the stacked conformer in the excited state dynamics. The adenine (1) La state can decay without a barrier to a conical intersection with the ground state. In contrast, the adenine (1) Lb and uracil S(U) states have minima that are separated from the intersections by sizeable barriers. Depending on the backbone conformation, the CT state can undergo inter-base hydrogen transfer and decay to the ground state through a conical intersection, or it can yield a long-lived minimum stabilized by a hydrogen bond between the two ribose rings. This suggests that the (1) Lb , S(U) and CT states of the stacked conformer may all contribute to the experimental lifetimes of 18 and 240 ps. We have also simulated the time evolution of the 2D-UV spectra and provide the specific fingerprint of each species in a recommended probe window between 25 000 and 38 000 cm(-1) in which decongested, clearly distinguishable spectra can be obtained. This is expected to allow the mechanistic scenarios to be discerned in the near future with the help of the corresponding experiments. Our results reveal the complexity of the photophysics of the relatively small ApU system, and the potential of 2D-UV spectroscopy to disentangle the photophysics of multichromophoric systems.

  3. Multiple Decay Mechanisms and 2D‐UV Spectroscopic Fingerprints of Singlet Excited Solvated Adenine‐Uracil Monophosphate

    PubMed Central

    Li, Quansong; Giussani, Angelo; Segarra‐Martí, Javier; Nenov, Artur; Rivalta, Ivan; Voityuk, Alexander A.; Mukamel, Shaul; Roca‐Sanjuán, Daniel

    2016-01-01

    Abstract The decay channels of singlet excited adenine uracil monophosphate (ApU) in water are studied with CASPT2//CASSCF:MM potential energy calculations and simulation of the 2D‐UV spectroscopic fingerprints with the aim of elucidating the role of the different electronic states of the stacked conformer in the excited state dynamics. The adenine 1La state can decay without a barrier to a conical intersection with the ground state. In contrast, the adenine 1Lb and uracil S(U) states have minima that are separated from the intersections by sizeable barriers. Depending on the backbone conformation, the CT state can undergo inter‐base hydrogen transfer and decay to the ground state through a conical intersection, or it can yield a long‐lived minimum stabilized by a hydrogen bond between the two ribose rings. This suggests that the 1Lb, S(U) and CT states of the stacked conformer may all contribute to the experimental lifetimes of 18 and 240 ps. We have also simulated the time evolution of the 2D‐UV spectra and provide the specific fingerprint of each species in a recommended probe window between 25 000 and 38 000 cm−1 in which decongested, clearly distinguishable spectra can be obtained. This is expected to allow the mechanistic scenarios to be discerned in the near future with the help of the corresponding experiments. Our results reveal the complexity of the photophysics of the relatively small ApU system, and the potential of 2D‐UV spectroscopy to disentangle the photophysics of multichromophoric systems. PMID:27113273

  4. Electronic states of BP, BP +, BP -, B 2P 2, B2P2- and B2P2+

    NASA Astrophysics Data System (ADS)

    Linguerri, Roberto; Komiha, Najia; Oswald, Rainer; Mitrushchenkov, Alexander; Rosmus, Pavel

    2008-05-01

    Using augmented sextuple zeta basis sets and internally contracted multireference configuration interaction (MRCI) wavefunctions, potential energy, electric dipole and transition moments have been computed for the X 3Π, a 1Σ +, b 1Π and A 3Σ - states of BP, X 2Σ + and A 2Π states of BP - and X 4Σ - and A 4Π states of BP +. From these data spectroscopic constants, radiative transition probabilities and photoelectron spectra of BP - and BP have been evaluated. The non-vanishing spin-orbit coupling elements between the four low lying triplet and singlet states of the neutral BP have also been calculated from MRCI wavefunctions. The treatment of the corresponding perturbations in the manifold of dense rovibrational states in the three lowest states would require a precise knowledge of the electronic excitation energies. Our best singlet-triplet separations (X-a) are calculated to be 2412 cm -1 (MRCI) and 2482 cm -1 (restricted coupled cluster with perturbative triples (RCCSD(T))) with an estimated error bound of about ±200 cm -1. All three states have long radiative lifetimes with cascading among the rovibrational levels of different states. The ionization energy IE e of BP is calculated to be 9.22 eV (MRCI) and 9.48 eV (RCCSD(T)), the electron affinity EA e 2.51 eV (MRCI) and 2.74 eV (RCCSD(T)). The photoelectron spectra of BP and BP - have been obtained from the Franck-Condon factors of the MRCI potentials. For the UV spectroscopy the dipole allowed radiative transition probabilities are given for A 3Σ - ↔ X 3Π, b 1Π ↔ a 1Σ + of BP, A 2Π ↔ X 2Σ + of BP - and A 4Π ↔ X 4Σ - of BP +. The ionization energy IE e of B 2P 2 of 8.71 eV and the electron affinity EA e of 2.34 eV have been calculated by the RCCSD(T)/aVQZ approach. Also the harmonic vibrational wavenumbers for the electronic ground states of the ions B2P2+ and B2P2- are given.

  5. A micro-payment architecture for P2P networks

    NASA Astrophysics Data System (ADS)

    Zhang, Jie; Zhao, Zheng; Xiong, Xiao; Shi, Qingwei

    2007-09-01

    An important goal in P2P networks is that all peers provide resources. However, free riding and tragedy of common are real issues in P2P networks. To resolve these problems, most of the existing work is concerning probabilistic estimation to evaluate the trustworthiness or mechanism design to provide incentive. Instead of design a protocol to solve free riding, we build a micro-payment architecture for these existing protocols using virtual currency which can be more precisely measured and easily be replaced by reputation or other tokens. Our system can avoid from long-term trust learning interactions and high cost of collecting and analyzing reputation information. It can also provide peers incentive to truly report their connection type and security to malicious attacks.

  6. Root proliferation in decaying roots and old root channels: A nutrient conservation mechanism in oligotrophic mangrove forests?

    USGS Publications Warehouse

    McKee, K.L.

    2001-01-01

    1. In oligotrophic habitats, proliferation of roots in nutrient-rich microsites may contribute to overall nutrient conservation by plants. Peat-based soils on mangrove islands in Belize are characterized by the presence of decaying roots and numerous old root channels (0.1-3.5 cm diameter) that become filled with living and highly branched roots of Rhizophora mangle and Avicennia germinans. The objectives of this study were to quantify the proliferation of roots in these microsites and to determine what causes this response. 2. Channels formed by the refractory remains of mangrove roots accounted for only 1-2% of total soil volume, but the proportion of roots found within channels varied from 9 to 24% of total live mass. Successive generations of roots growing inside increasingly smaller root channels were also found. 3. When artificial channels constructed of PVC pipe were buried in the peat for 2 years, those filled with nutrient-rich organic matter had six times more roots than empty or sand-filled channels, indicating a response to greater nutrient availability rather than to greater space or less impedance to root growth. 4. Root proliferation inside decaying roots may improve recovery of nutrients released from decomposing tissues before they can be leached or immobilized in this intertidal environment. Greatest root proliferation in channels occurred in interior forest zones characterized by greater soil waterlogging, which suggests that this may be a strategy for nutrient capture that minimizes oxygen losses from the whole root system. 5. Improved efficiency of nutrient acquisition at the individual plant level has implications for nutrient economy at the ecosystem level and may explain, in part, how mangroves persist and grow in nutrient-poor environments.

  7. Regulated Inositol‐Requiring Protein 1‐Dependent Decay as a Mechanism of Corin RNA and Protein Deficiency in Advanced Human Systolic Heart Failure

    PubMed Central

    Lee, Rebecca; Xu, Bin; Rame, J. Eduardo; Felkin, Leanne E.; Barton, Paul; Dries, Daniel L.

    2014-01-01

    Background The compensatory actions of the endogenous natriuretic peptide system require adequate processing of natriuretic peptide pro‐hormones into biologically active, carboxyl‐terminal fragments. Natriuretic peptide pro‐peptide processing is accomplished by corin, a transmembrane serine protease expressed by cardiomyocytes. Brain natriuretic peptide (BNP) processing is inadequate in advanced heart failure and is independently associated with adverse outcomes; however, the molecular mechanisms causing impaired BNP processing are not understood. We hypothesized that the development of endoplasmic reticulum stress in cardiomyocytes in advanced heart failure triggers inositol‐requiring protein 1 (IRE1)‐dependent corin mRNA decay, which would favor a molecular substrate favoring impaired natriuretic peptide pro‐peptide processing. Methods and Results Two independent samples of hearts obtained from patients with advanced heart failure at transplant demonstrated that corin RNA was reduced as Atrial natriuretic peptide (ANP)/BNP RNA increased. Increases in spliced X‐box protein 1, a marker for IRE1‐endoribonuclease activity, were associated with decreased corin RNA. Moreover, ≈50% of the hearts demonstrated significant reductions in corin RNA and protein as compared to the nonfailing control sample. In vitro experiments demonstrated that induction of endoplasmic reticulum stress in cultured cardiomyocytes with thapsigargin activated IRE1's endoribonuclease activity and time‐dependent reductions in corin mRNA. In HL‐1 cells, overexpression of IRE1 activated IRE1 endoribonuclease activity and caused corin mRNA decay, whereas IRE1‐RNA interference with shRNA attenuated corin mRNA decay after induction of endoplasmic reticulum stress with thapsigargin. Pre‐treatment of cells with Actinomycin D to inhibit transcription did not alter the magnitude or time course of thapsigargin‐induced corin mRNA decline, supporting the hypothesis that this was

  8. Capacity Decay Mechanism of Microporous Separator-Based All-Vanadium Redox Flow Batteries and its Recovery

    SciTech Connect

    Li, Bin; Luo, Qingtao; Wei, Xiaoliang; Nie, Zimin; Thomsen, Edwin; Chen, Baowei; Sprenkle, Vincent; Wang, Wei

    2013-10-29

    For all vanadium redox flow batteries (VRBs) with porous separators as membranes, convection effect is found to play a dominant role in the capacity decay of the cells over cycling by investigating the relationship between electrical performances and electrolyte compositions at both positive and negative sides. Although the concentration of total vanadium ions hardly changes at both sides over cycling, the net transfer of solutions from one side to another and thus asymmetrical valance of vanadium ions at both sides lead to the capacity fading and lower energy efficiency, which is confirmed to result from the hydraulic pressure differential at both sides of separators. In this paper, the hydraulic pressures of solutions at both sides can be in-situ monitored, and regulated by varying the gas pressures in electrolyte tanks. It is found that the capacity can be stabilized and the net transfer of solutions can be prevented by slightly tailoring the hydraulic pressure differential at both sides of separators, which, however, doesn’t work for Nafion membranes, suggesting the negligible convection factor in flow cells using Nafion membranes. Therefore, the possibility of porous separators allows long-term running for VRBs without capacity loss, highlighting a new pathway to develop membranes used in VRBs.

  9. Radiative lifetimes of the 2s2p2(4P) metastable levels of N III

    NASA Technical Reports Server (NTRS)

    Fang, Z.; Kwong, Victor H. S.; Parkinson, W. H.

    1993-01-01

    The radiative decay rates of N III 175 nm intersystem lines were measured in the laboratory by recording the time dependence of photon intensities emitted as the 2s2p2(4P) metastable term of N(2+) ions decay to the 2s22p(2P0) ground term. A cylindrical radio frequency ion trap was used to store the electron impact-produced N(2+) ions. The radiative decay signals were analyzed by multiexponential least-squares fits to the data. The measured radiative decay rates to the ground term are 1019(+/- 64)/s for 4P sub 1/2, 74.5(+/- 5.4)/s for 4P sub 3/2, and 308( +/- 22)/s for 4P sub 5/2. Comparisons of the measured values with theoretical values are presented.

  10. Modulation of K2P2.1 and K2P10.1 K+ channel sensitivity to carvedilol by alternative mRNA translation initiation

    PubMed Central

    Kisselbach, J; Seyler, C; Schweizer, P A; Gerstberger, R; Becker, R; Katus, H A; Thomas, D

    2014-01-01

    Background and Purpose The β-receptor antagonist carvedilol blocks a range of ion channels. K2P2.1 (TREK1) and K2P10.1 (TREK2) channels are expressed in the heart and regulated by alternative translation initiation (ATI) of their mRNA, producing functionally distinct channel variants. The first objective was to investigate acute effects of carvedilol on human K2P2.1 and K2P10.1 channels. Second, we sought to study ATI-dependent modulation of K2P K+ current sensitivity to carvedilol. Experimental Approach Using standard electrophysiological techniques, we recorded currents from wild-type and mutant K2P2.1 and K2P10.1 channels in Xenopus oocytes and HEK 293 cells. Key Results Carvedilol concentration-dependently inhibited K2P2.1 channels (IC50,oocytes = 20.3 μM; IC50,HEK = 1.6 μM) and this inhibition was frequency-independent. When K2P2.1 isoforms generated by ATI were studied separately in oocytes, the IC50 value for carvedilol inhibition of full-length channels (16.5 μM) was almost 5-fold less than that for the truncated channel variant (IC50 = 79.0 μM). Similarly, the related K2P10.1 channels were blocked by carvedilol (IC50,oocytes = 24.0 μM; IC50,HEK = 7.6 μM) and subject to ATI-dependent modulation of drug sensitivity. Conclusions and Implications Carvedilol targets K2P2.1 and K2P10.1 K+ channels. This previously unrecognized mechanism supports a general role of cardiac K2P channels as antiarrhythmic drug targets. Furthermore, the work reveals that the sensitivity of the cardiac ion channels K2P2.1 and K2P10.1 to block was modulated by alternative mRNA translation initiation. PMID:25168769

  11. Pseudo-rephasing and pseudo-free-induction-decay mechanism in two-color three-pulse photon echo of a binary system.

    PubMed

    Dong, Hui; Ryu, Ian Seungwan; Fleming, Graham R

    2013-12-27

    We investigate the two-color three-pulse photon echo peak shift in a (left-right) binary system, where each component consists of a heterodimer. On the basis of the model, we find that the effect of the excitonic asymmetry between two components leads to an additional factor in the peak shift. A pseudo-rephasing and pseudo-free-induction-decay mechanism is proposed to explain the resultant negative peak shift, when the differences between the two left/right components have the opposite sign. In such a case, estimates of the electronic coupling strength via two- and one-color peak shift experiments lead to an underestimate of the coupling magnitude.

  12. Eukaryotic Initiation Factor 4G Suppresses Nonsense-Mediated mRNA Decay by Two Genetically Separable Mechanisms

    PubMed Central

    Joncourt, Raphael; Eberle, Andrea B.; Rufener, Simone C.; Mühlemann, Oliver

    2014-01-01

    Nonsense-mediated mRNA decay (NMD), which is best known for degrading mRNAs with premature termination codons (PTCs), is thought to be triggered by aberrant translation termination at stop codons located in an environment of the mRNP that is devoid of signals necessary for proper termination. In mammals, the cytoplasmic poly(A)-binding protein 1 (PABPC1) has been reported to promote correct termination and therewith antagonize NMD by interacting with the eukaryotic release factors 1 (eRF1) and 3 (eRF3). Using tethering assays in which proteins of interest are recruited as MS2 fusions to a NMD reporter transcript, we show that the three N-terminal RNA recognition motifs (RRMs) of PABPC1 are sufficient to antagonize NMD, while the eRF3-interacting C-terminal domain is dispensable. The RRM1-3 portion of PABPC1 interacts with eukaryotic initiation factor 4G (eIF4G) and tethering of eIF4G to the NMD reporter also suppresses NMD. We identified the interactions of the eIF4G N-terminus with PABPC1 and the eIF4G core domain with eIF3 as two genetically separable features that independently enable tethered eIF4G to inhibit NMD. Collectively, our results reveal a function of PABPC1, eIF4G and eIF3 in translation termination and NMD suppression, and they provide additional evidence for a tight coupling between translation termination and initiation. PMID:25148142

  13. Counterflow driven by swirl decay

    NASA Astrophysics Data System (ADS)

    Shtern, Vladimir N.; Borissov, Anatoli A.

    2010-06-01

    The global meridional circulation of a viscous fluid, caused by swirl decay in a cylindrical container, is studied. To this end, a new solution to the Navier-Stokes equations is obtained, and simple experiments are performed to verify the predictions of the theory. The swirl decay mechanism explains elongated counterflows in hydrocyclones and vortex tubes sometimes extending over a hundred diameters.

  14. Fuzzy-rule-based Adaptive Resource Control for Information Sharing in P2P Networks

    NASA Astrophysics Data System (ADS)

    Wu, Zhengping; Wu, Hao

    With more and more peer-to-peer (P2P) technologies available for online collaboration and information sharing, people can launch more and more collaborative work in online social networks with friends, colleagues, and even strangers. Without face-to-face interactions, the question of who can be trusted and then share information with becomes a big concern of a user in these online social networks. This paper introduces an adaptive control service using fuzzy logic in preference definition for P2P information sharing control, and designs a novel decision-making mechanism using formal fuzzy rules and reasoning mechanisms adjusting P2P information sharing status following individual users' preferences. Applications of this adaptive control service into different information sharing environments show that this service can provide a convenient and accurate P2P information sharing control for individual users in P2P networks.

  15. Security Issues for P2P-Based Voice- and Video-Streaming Applications

    NASA Astrophysics Data System (ADS)

    Seedorf, Jan

    P2P computing offers a new interesting field for security researchers. Being highly distributed and lacking centralised, trusted entities for bootstrapping security mechanisms, these systems demand novel approaches for decentralised security solutions.

  16. Mechanisms of fluorescence decays of colloidal CdSe-CdS/ZnS quantum dots unraveled by time-resolved fluorescence measurement.

    PubMed

    Xu, Hao; Chmyrov, Volodymyr; Widengren, Jerker; Brismar, Hjalmar; Fu, Ying

    2015-11-01

    By narrowing the detection bandpass and increasing the signal-to-noise ratio in measuring the time-resolved fluorescence decay spectrum of colloidal CdSe-CdS/ZnS quantum dots (QDs), we show that directly after the photoexcitation, the fluorescence decay spectrum is characterized by a single exponential decay, which represents the energy relaxation of the photogenerated exciton from its initial high-energy state to the ground exciton state. The fluorescence decay spectrum of long decay time is in the form of β/t(2), where β is the radiative recombination time of the ground-state exciton and t is the decay time. Our findings provide us with a direct and quantitative link between fluorescence decay measurement data and fundamental photophysics of QD exciton, thereby leading to a novel way of applying colloidal QDs to study microscopic, physical and chemical processes in many fields including biomedicine. PMID:26426293

  17. Mechanisms of fluorescence decays of colloidal CdSe-CdS/ZnS quantum dots unraveled by time-resolved fluorescence measurement.

    PubMed

    Xu, Hao; Chmyrov, Volodymyr; Widengren, Jerker; Brismar, Hjalmar; Fu, Ying

    2015-11-01

    By narrowing the detection bandpass and increasing the signal-to-noise ratio in measuring the time-resolved fluorescence decay spectrum of colloidal CdSe-CdS/ZnS quantum dots (QDs), we show that directly after the photoexcitation, the fluorescence decay spectrum is characterized by a single exponential decay, which represents the energy relaxation of the photogenerated exciton from its initial high-energy state to the ground exciton state. The fluorescence decay spectrum of long decay time is in the form of β/t(2), where β is the radiative recombination time of the ground-state exciton and t is the decay time. Our findings provide us with a direct and quantitative link between fluorescence decay measurement data and fundamental photophysics of QD exciton, thereby leading to a novel way of applying colloidal QDs to study microscopic, physical and chemical processes in many fields including biomedicine.

  18. Therapeutic targeting of two-pore-domain potassium (K(2P)) channels in the cardiovascular system.

    PubMed

    Wiedmann, Felix; Schmidt, Constanze; Lugenbiel, Patrick; Staudacher, Ingo; Rahm, Ann-Kathrin; Seyler, Claudia; Schweizer, Patrick A; Katus, Hugo A; Thomas, Dierk

    2016-05-01

    The improvement of treatment strategies in cardiovascular medicine is an ongoing process that requires constant optimization. The ability of a therapeutic intervention to prevent cardiovascular pathology largely depends on its capacity to suppress the underlying mechanisms. Attenuation or reversal of disease-specific pathways has emerged as a promising paradigm, providing a mechanistic rationale for patient-tailored therapy. Two-pore-domain K(+) (K(2P)) channels conduct outward K(+) currents that stabilize the resting membrane potential and facilitate action potential repolarization. K(2P) expression in the cardiovascular system and polymodal K2P current regulation suggest functional significance and potential therapeutic roles of the channels. Recent work has focused primarily on K(2P)1.1 [tandem of pore domains in a weak inwardly rectifying K(+) channel (TWIK)-1], K(2P)2.1 [TWIK-related K(+) channel (TREK)-1], and K(2P)3.1 [TWIK-related acid-sensitive K(+) channel (TASK)-1] channels and their role in heart and vessels. K(2P) currents have been implicated in atrial and ventricular arrhythmogenesis and in setting the vascular tone. Furthermore, the association of genetic alterations in K(2P)3.1 channels with atrial fibrillation, cardiac conduction disorders and pulmonary arterial hypertension demonstrates the relevance of the channels in cardiovascular disease. The function, regulation and clinical significance of cardiovascular K(2P) channels are summarized in the present review, and therapeutic options are emphasized.

  19. Pseudogene CYP4Z2P 3′UTR promotes angiogenesis in breast cancer

    SciTech Connect

    Zheng, Lufeng; Li, Xiaoman; Gu, Yi; Ma, Yihua; Xi, Tao

    2014-10-24

    Highlights: • A new critical role of pseudogene CYP4Z2P 3′UTR in breast cancer is proposed. • We examine the level of pseudogene CYP4Z2P 3′UTR in breast cancer tissues. • The functions of CYP4Z2P 3′UTR and mechanism were studied. • The mechanism provides new insights for the breast cancer progression. - Abstract: Pseudogenes have long been marked as “false” genes, which are similar with real genes but have no apparent function. The 3′UTR is well-known to regulate gene expression post-transcriptionally. Our recent evidence, however, indicates novel functional roles of pseudogene CYP4Z2P 3′UTR (Z2P-UTR). We found that ectopic expression of Z2P-UTR in breast cancer cells significantly increased the expression of VEGF-A without affecting cell proliferation in vitro. Meanwhile, conditioned medium (CM) from Z2P-UTR overexpression cells enhanced proliferation, migration and tube formation of HUVEC, and promoted angiogenesis in ex vivo models. Also, CM increased the expression of VEGFR2 in HUVEC. Our data suggest that Z2P-UTR can promote breast cancer angiogenesis partly via paracrine pathway of VEGF-A/VEGFR2.

  20. Mechanism and dynamics of intramolecular triplet state decay of 1-propyl-4-thiouracil and its α-methyl-substituted derivatives studied in perfluoro-1,3-dimethylcyclohexane.

    PubMed

    Wenska, Grazyna; Taras-Goślińska, Katarzyna; Łukaszewicz, Adam; Burdziński, Gotard; Koput, Jacek; Maciejewski, Andrzej

    2011-08-01

    The absorption, phosphorescence and phosphorescence excitation spectra, phosphorescence quantum yields, and T(1) excited state lifetimes of four 4-thiouracil derivatives were measured for the first time in chemically inert and very weakly interacting perfluoro-1,3-dimethylcyclohexane at room temperature. The set of the 4-thiouracil derivatives comprises 1-propyl-4-thiouracil (PTU) and the related compounds having a methyl substituent at the position α to the thiocarbonyl group, namely 1-propyl-4-thiothymine (PTT), 1,3-dimethyl-4-thiouracil (DMTU), and 1-methyl-3-trideuteriomethyl-4-thiouracil ([D(3)]DMTU). Quantitative information on the intramolecular decay of the T(1) excited state of the four 4-thiouracil derivatives is presented, and the mechanism and dynamics of this process are discussed. In the absence of self quenching and solvent induced deactivation, the T(1) decay of the four 4-thiouracil derivatives was dominated by intramolecular nonradiative processes (NR). The values of the rate constant k(NR) in DMTU and [D(3)]DMTU are about 4 times larger than that in PTT and about 3 times larger than that in PTU. The reasons for the enhanced nonradiative rate constant in DMTU are discussed. It is concluded that the faster rate of the nonradiative processes in DMTU is related to a larger contribution from mixing of the T(2) (nπ*) state into the lowest energy T(1) (ππ*) state, as compared to the analogous coupling in PTU and PTT. This conclusion is supported by ab initio calculations performed at the EOM-CC2/aug-cc-pVDZ level of theory. The energy spacing between the T(2) (nπ*) and T(1) (ππ*) states is estimated to be about 500, 1100, and 2000 cm(-1) for DMTU, PTU, and PTT, respectively. Among the three compounds in question, the predicted energy spacing is thus the smallest for DMTU.

  1. Near-IR laser generation of a high-energy conformer of L-alanine and the mechanism of its decay in a low-temperature nitrogen matrix.

    PubMed

    Nunes, Cláudio M; Lapinski, Leszek; Fausto, Rui; Reva, Igor

    2013-03-28

    Monomers of L-alanine (ALA) were isolated in cryogenic nitrogen matrices at 14 K. Two conformers were identified for the compound trapped from the gas-phase into the solid nitrogen environment. The potential energy surface (PES) of ALA was theoretically calculated at the MP2 and QCISD levels. Twelve minima were located on this PES. Seven low-energy conformers fall within the 0-10 kJ mol(-1) range and should be appreciably populated in the equilibrium gas phase prior to deposition. Observation of only two forms in the matrices is explained in terms of calculated barriers to conformational rearrangements. All conformers with the O=C-O-H moiety in the cis orientation are separated by low barriers and collapse to the most stable form I during deposition of the matrix onto the low-temperature substrate. The second observed form II has the O=C-O-H group in the trans orientation. The remaining trans forms have very high relative energies (between 24 and 30 kJ mol(-1)) and are not populated. The high-energy trans form VI, that differs from I only by rotation of the OH group, was found to be separated from other conformers by barriers that are high enough to open a perspective for its stabilization in a matrix. The form VI was photoproduced in situ by narrow-band near-infrared irradiation of the samples at 6935-6910 cm(-1), where the first overtone of the OH stretching vibration in form I appears. The photogenerated form VI decays in N2 matrices back to conformer I with a characteristic decay time of ∼15 min. The mechanism of the VI → I relaxation is rationalized in terms of the proton tunneling.

  2. Seal Out Tooth Decay

    MedlinePlus

    ... Topics > Tooth Decay (Caries) > Seal Out Tooth Decay Seal Out Tooth Decay Main Content What are dental ... back teeth decay so easily? Who should get seal​ants? Should sealants be put on baby teeth? ...

  3. Interatomic Coulombic decay following resonant core excitation of Ar in argon dimer

    SciTech Connect

    Miteva, T.; Chiang, Y.-C.; Kuleff, A. I.; Gokhberg, K. Cederbaum, L. S.; Kolorenč, P.

    2014-08-14

    A scheme utilizing excitation of core electrons followed by the resonant-Auger – interatomic Coulombic decay (RA-ICD) cascade was recently proposed as a means of controlling the generation site and energies of slow ICD electrons. This control mechanism was verified in a series of experiments in rare gas dimers. In this article, we present fully ab initio computed ICD electron and kinetic energy release spectra produced following 2p{sub 3/2} → 4s, 2p{sub 1/2} → 4s, and 2p{sub 3/2} → 3d core excitations of Ar in Ar{sub 2}. We demonstrate that the manifold of ICD states populated in the resonant Auger process comprises two groups. One consists of lower energy ionization satellites characterized by fast interatomic decay, while the other consists of slow decaying higher energy ionization satellites. We show that accurate description of nuclear dynamics in the latter ICD states is crucial for obtaining theoretical electron and kinetic energy release spectra in good agreement with the experiment.

  4. Three-body decay of many-body resonances

    SciTech Connect

    Jensen, A.S.; Fedorov, D.V.; Fynbo, H.O.U.; Garrido, E.

    2005-10-14

    We use the hyperspherical coordinates to describe decay of many-body resonances. Direct and sequential decay are described by different paths in the distances between the particles. We generalize the WKB expression for the {alpha}-decay width to decay of three charged particles. Decay mechanisms and resonance structures are computed in coordinate space. The energy distributions of the particles after decay are discussed. Moderate s-wave scattering lengths prefer decay via corresponding virtual state possibly leaving unique fingerprints of this reminiscence of the Efimov effect in the decay of excited states. Numerical illustrations are resonances in 6He, 12C, 17Ne.

  5. Supporting Collaboration and Creativity Through Mobile P2P Computing

    NASA Astrophysics Data System (ADS)

    Wierzbicki, Adam; Datta, Anwitaman; Żaczek, Łukasz; Rzadca, Krzysztof

    Among many potential applications of mobile P2P systems, collaboration applications are among the most prominent. Examples of applications such as Groove (although not intended for mobile networks), collaboration tools for disaster recovery (the WORKPAD project), and Skype's collaboration extensions, all demonstrate the potential of P2P collaborative applications. Yet, the development of such applications for mobile P2P systems is still difficult because of the lack of middleware.

  6. Gating, Regulation, and Structure in K2P K+ Channels: In Varietate Concordia?

    PubMed

    Niemeyer, María Isabel; Cid, L Pablo; González, Wendy; Sepúlveda, Francisco V

    2016-09-01

    K2P K(+) channels with two pore domains in tandem associate as dimers to produce so-called background conductances that are regulated by a variety of stimuli. Whereas gating in K2P channels has been poorly understood, recent developments have provided important clues regarding the gating mechanism for this family of proteins. Two modes of gating present in other K(+) channels have been considered. The first is the so-called activation gating that occurs by bundle crossing and the splaying apart of pore-lining helices commanding ion passage. The second mode involves a change in conformation at the selectivity filter (SF), which impedes ion flow at this narrow portion of the conduction pathway and accounts for extracellular pH modulation of several K2P channels. Although some evidence supports the existence of an activation gate in K2P channels, recent results suggest that perhaps all stimuli, even those sensed at a distant location in the protein, are also mediated by SF gating. Recently resolved crystal structures of K2P channels in conductive and nonconductive conformations revealed that the nonconductive state is reached by blockade by a lipid acyl chain that gains access to the channel cavity through intramembrane fenestrations. Here we discuss whether this novel type of gating, proposed so far only for membrane tension gating, might mediate gating in response to other stimuli or whether SF gating is the only type of opening/closing mechanism present in K2P channels. PMID:27268784

  7. The importance of L1 ORF2p cryptic sequence to ORF2p fragment-mediated cytotoxicity.

    PubMed

    Christian, Claiborne M; Kines, Kristine J; Belancio, Victoria P

    2016-01-01

    The Long Interspersed Element 1 (LINE1 or L1) ORF2 protein (ORF2p) can cause DNA damage through the activity of its endonuclease domain (EN). The DNA double-strand breaks (DSB) introduced by the ORF2p EN have the potential to be mutagenic. Previously, our lab has shown that ORF2p fragments containing the EN domain could be expressed in mammalian cells and have variable cytotoxicity. Inclusion of the ORF2p sequence C-terminal to the EN domain in these fragments both reduced the cytotoxicity of these fragments and increased their presence in the nucleus as detected by Western blot analysis. Here, we identify the amino acids (aa 270-274) in the newly-identified ORF2p Cryptic region (Cry) that may be important to the subcellular localization and cytotoxic potential of these EN-containing ORF2p fragments. PMID:27583184

  8. Isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions

    NASA Astrophysics Data System (ADS)

    Zubova, N. A.; Malyshev, A. V.; Tupitsyn, I. I.; Shabaev, V. M.; Kozhedub, Y. S.; Plunien, G.; Brandau, C.; Stöhlker, Th.

    2016-05-01

    Isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions are evaluated for a wide range of the nuclear charge number: Z =8 -92 . The calculations of the relativistic nuclear recoil and nuclear size effects are performed using a large-scale configuration-interaction Dirac-Fock-Sturm method. The corresponding QED corrections are also taken into account. The results of the calculations are compared with the theoretical values obtained with other methods. The accuracy of the isotope shifts of the 2 p3 /2-2 p1 /2 transition in B-like ions is significantly improved.

  9. An Efficient, Scalable and Robust P2P Overlay for Autonomic Communication

    NASA Astrophysics Data System (ADS)

    Li, Deng; Liu, Hui; Vasilakos, Athanasios

    The term Autonomic Communication (AC) refers to self-managing systems which are capable of supporting self-configuration, self-healing and self-optimization. However, information reflection and collection, lack of centralized control, non-cooperation and so on are just some of the challenges within AC systems. Since many self-* properties (e.g. selfconfiguration, self-optimization, self-healing, and self-protecting) are achieved by a group of autonomous entities that coordinate in a peer-to-peer (P2P) fashion, it has opened the door to migrating research techniques from P2P systems. P2P's meaning can be better understood with a set of key characteristics similar to AC: Decentralized organization, Self-organizing nature (i.e. adaptability), Resource sharing and aggregation, and Fault-tolerance. However, not all P2P systems are compatible with AC. Unstructured systems are designed more specifically than structured systems for the heterogeneous Internet environment, where the nodes' persistence and availability are not guaranteed. Motivated by the challenges in AC and based on comprehensive analysis of popular P2P applications, three correlative standards for evaluating the compatibility of a P2P system with AC are presented in this chapter. According to these standards, a novel Efficient, Scalable and Robust (ESR) P2P overlay is proposed. Differing from current structured and unstructured, or meshed and tree-like P2P overlay, the ESR is a whole new three dimensional structure to improve the efficiency of routing, while information exchanges take in immediate neighbors with local information to make the system scalable and fault-tolerant. Furthermore, rather than a complex game theory or incentive mechanism, asimple but effective punish mechanism has been presented based on a new ID structure which can guarantee the continuity of each node's record in order to discourage negative behavior on an autonomous environment as AC.

  10. Nucleophilic substitution at phosphorus centers (SN2@p).

    PubMed

    van Bochove, Marc A; Swart, Marcel; Bickelhaupt, F Matthias

    2007-12-01

    We have studied the characteristics of archetypal model systems for bimolecular nucleophilic substitution at phosphorus (SN2@P) and, for comparison, at carbon (SN2@C) and silicon (SN2@Si) centers. In our studies, we applied the generalized gradient approximation (GGA) of density functional theory (DFT) at the OLYP/TZ2P level. Our model systems cover nucleophilic substitution at carbon in X(-)+CH3Y (SN2@C), at silicon in X(-)+SiH3Y (SN2@Si), at tricoordinate phosphorus in X(-)+PH2Y (SN2@P3), and at tetracoordinate phosphorus in X(-)+POH2Y (SN2@P4). The main feature of going from SN2@C to SN2@P is the loss of the characteristic double-well potential energy surface (PES) involving a transition state [X--CH3--Y]- and the occurrence of a single-well PES with a stable transition complex, namely, [X--PH2--Y]- or [X--POH2--Y](-). The differences between SN2@P3 and SN2@P4 are relatively small. We explored both the symmetric and asymmetric (i.e. X, Y=Cl, OH) SN2 reactions in our model systems, the competition between backside and frontside pathways, and the dependence of the reactions on the conformation of the reactants. Furthermore, we studied the effect, on the symmetric and asymmetric SN2@P3 and S(N)2@P4 reactions, of replacing hydrogen substituents at the phosphorus centers by chlorine and fluorine in the model systems X(-)+PR2Y and X(-)+POR2Y, with R=Cl, F. An interesting phenomenon is the occurrence of a triple-well PES not only in the symmetric, but also in the asymmetric SN2@P4 reactions of X(-)+POCl2--Y. PMID:17990249

  11. Structure And Function of the Yeast U-Box-Containing Ubiquitin Ligase Ufd2p

    SciTech Connect

    Tu, D.; Li, W.; Ye, Y.; Brunger, A.T.

    2009-06-04

    Proteins conjugated by Lys-48-linked polyubiquitin chains are preferred substrates of the eukaryotic proteasome. Polyubiquitination requires an activating enzyme (E1), a conjugating enzyme (E2), and a ligase (E3). Occasionally, these enzymes only assemble short ubiquitin oligomers, and their extension to full length involves a ubiquitin elongating factor termed E4. Ufd2p, as the first E4 identified to date, is involved in the degradation of misfolded proteins of the endoplasmic reticulum and of a ubiquitin-{beta}-GAL fusion substrate in Saccharomyces cerevisiae. The mechanism of action of Ufd2p is unknown. Here we describe the crystal structure of the full-length yeast Ufd2p protein. Ufd2p has an elongated shape consisting of several irregular Armadillo-like repeats with two helical hairpins protruding from it and a U-box domain flexibly attached to its C terminus. The U-box of Ufd2p has a fold similar to that of the RING (Really Interesting New Gene) domain that is present in certain ubiquitin ligases. Accordingly, Ufd2p has all of the hallmarks of a RING finger-containing ubiquitin ligase: it associates with its cognate E2 Ubc4p via its U-box domain and catalyzes the transfer of ubiquitin from the E2 active site to Ufd2p itself or to an acceptor ubiquitin molecule to form unanchored diubiquitin oligomers. Thus, Ufd2p can function as a bona fide E3 ubiquitin ligase to promote ubiquitin chain elongation on a substrate.

  12. The observation of decay

    NASA Astrophysics Data System (ADS)

    Sudbery, A.

    1984-10-01

    It is argued that the usual formulation of quantum mechanics does not satisfactorily describe physical change: the standard formula for a transition probability does not follow from the postulates. Instead, these yield the paradox that a watched pot never bolls (sometimes called "Zeno's paradox"). The paradox is reviewed and the possibility of avoiding it is discussed. A simple model of a decaying system is analysed; the system is then considered in continuous interaction with an apparatus designed to observe the time development of the system. In the light of this analysis, the possibility is considered of replacing the usual (diserete) projection postulate by a continuous projection postulate.

  13. Secure mobile agent for telemedicine based on P2P networks.

    PubMed

    Hsu, Wen-Shin; Pan, Jiann-I

    2013-06-01

    Exploring intelligent mobile agent (MA) technology for assisting medical services or transmitting personal patient-health information in telemedicine applications has been widely investigated. Conversely, peer-to-peer (P2P) networking has become one of the most popular applications used in the Internet because of its benefits for easy-to-manage resources and because it balances workloads. Therefore, constructing an agent-based telemedicine platform based on P2P networking architecture is necessary. The main purpose of this paper is to construct a safe agent-based telemedicine that based on P2P networking architecture. Two themes are addressed in this paper: (a) the P2P network architecture for an agent-based telemedicine service, and (b) the security mechanisms for the proposed telemedicine networking architecture. When an MA contains patient information and migrates from one host to another through the Internet, it can be attacked by other software agents or agent platforms that can illegally access patient information. The proposed P2P network architecture is based on the JXTA protocol and provides two types of telemedicine service models: the predictable service model and unpredictable service model. This architecture employs a two-layer safety mechanism for MAs (i.e., time-limited black boxes and RSA undetachable signature technologies), to provide a secure solution for agent-based telemedicine services. PMID:23605144

  14. P2P-based botnets: structural analysis, monitoring, and mitigation

    SciTech Connect

    Yan, Guanhua; Eidenbenz, Stephan; Ha, Duc T; Ngo, Hung Q

    2008-01-01

    Botnets, which are networks of compromised machines that are controlled by one or a group of attackers, have emerged as one of the most serious security threats on the Internet. With an army of bots at the scale of tens of thousands of hosts or even as large as 1.5 million PCs, the computational power of botnets can be leveraged to launch large-scale DDoS (Distributed Denial of Service) attacks, sending spamming emails, stealing identities and financial information, etc. As detection and mitigation techniques against botnets have been stepped up in recent years, attackers are also constantly improving their strategies to operate these botnets. The first generation of botnets typically employ IRC (Internet Relay Chat) channels as their command and control (C&C) centers. Though simple and easy to deploy, the centralized C&C mechanism of such botnets has made them prone to being detected and disabled. Against this backdrop, peer-to-peer (P2P) based botnets have emerged as a new generation of botnets which can conceal their C&C communication. Recently, P2P networks have emerged as a covert communication platform for malicious programs known as bots. As popular distributed systems, they allow bots to communicate easily while protecting the botmaster from being discovered. Existing work on P2P-based hotnets mainly focuses on measurement of botnet sizes. In this work, through simulation, we study extensively the structure of P2P networks running Kademlia, one of a few widely used P2P protocols in practice. Our simulation testbed incorporates the actual code of a real Kademlia client software to achieve great realism, and distributed event-driven simulation techniques to achieve high scalability. Using this testbed, we analyze the scaling, reachability, clustering, and centrality properties of P2P-based botnets from a graph-theoretical perspective. We further demonstrate experimentally and theoretically that monitoring bot activities in a P2P network is difficult

  15. Trisomy 2p: Analysis of unusual phenotypic findings

    SciTech Connect

    Lurie, I.W.; Ilyina, H.G.; Gurevich, D.B.

    1995-01-16

    We present three probands with partial trisomies 2p21-23 due to ins(4;2)(q21;p21p23) pat, 2p23-pter due to t(2;4)(p23;q35)mat, and 2p21-pter due to t(2;11)(p21;q23.3)mat. More than 50 cases of partial trisomy 2p have been reviewed and some abnormalities, unusual for most other types of structural autosomal imbalance, have been found in patients with inherited forms of 2p trisomy and in their non-karyotyped sibs. Neural tube defects (anencephaly, occipital encephalocele, and spina bifida) were found in five probands and 4/6 affected non-karyotyped sibs. The only triplicated segment common to all was 2p24. Different forms of {open_quotes}broncho-pulmonary a/hypoplasia{close_quotes} (including two cases of lung agenesis) were described in four patients (overlapping triplicated segment was 2p21-p25). Three patients (with overlapping triplicated segment 2p23-p25) had diaphragmatic hernia. Abnormal rotation of the heart or L-transposition of large vessels (with or without visceral heterotaxia) was found in two infants (overlapping triplicated segment 2p23-p24). In two patients with common triplicated segment 2p22.3-p25, neuroblastoma has been described. The occurrence of all these defects may be explained either by the action of the same gene(s) mapped to 2p24 or by action of some independent factors located in different segments of the short arm. Although the latter hypothesis is much less probable, it can not be rejected at the present time. We propose the existence of a genetic system controlling surveillance of an abnormal embryo to explain the phenotypic differences between patients with the same imbalance within a family. In some {open_quotes}restrictive{close_quotes} combinations the abnormal embryos will die, although in {open_quotes}permissive{close_quotes} combinations they can survive. 47 refs., 2 figs., 3 tabs.

  16. Calculation of total differential cross section: Na(/sup 2/P)+Xe p

    SciTech Connect

    DeVries, P.L.

    1984-03-01

    A quantum-mechanical treatment is used to determine the total differential cross section for collisions of excited sodium atoms with xenon. A rainbowlike structure in the angular distribution is predicted for collisions involving sodium in the /sup 2/P/sub 1/2/ state.

  17. Network Awareness in P2P-TV Applications

    NASA Astrophysics Data System (ADS)

    Traverso, Stefano; Leonardi, Emilio; Mellia, Marco; Meo, Michela

    The increasing popularity of applications for video-streaming based on P2P paradigm (P2P-TV) is raising the interest of both broadcasters and network operators. The former see a promising technology to reduce the cost of streaming content over the Internet, while offering a world-wide service. The latter instead fear that the traffic offered by these applications can grow without control, affecting other services, and possibly causing network congestion and collapse. The “Network-Aware P2P-TV Application over Wise Networks” FP7 project aims at studying and developing a novel P2P-TV application offering the chance to broadcast high definition video to broadcasters and to carefully manage the traffic offered by peers to the network, therefore avoiding worries to Internet providers about network overload. In such context, we design a simulator to evaluate performance of different P2P-TV solutions, to compare them both considering end-users’ and network providers’ perspectives, such as quality of service perceived by subscribers and link utilization. In this paper, we provide some results that show how effective can be a network aware P2P-TV system.

  18. Genetic heterogeneity of gingival fibromatosis on chromosome 2p

    PubMed Central

    Shashi, V.; Pallos, D.; Pettenati, M.; Cortelli, J.; Fryns, J.; von Kap-Herr, C.; Hart, T.

    1999-01-01

    Gingival fibromatosis (GF) occurs in several genetic forms as a simple Mendelian trait, in malformation syndromes, and in some chromosomal disorders. Specific genes responsible for GF have not been identified. An autosomal dominant form of hereditary gingival fibromatosis (HGF, MIM 135300) was recently mapped to chromosome 2p21 in a large Brazilian family and there was an earlier report of GF in a boy with a cytogenetic duplication involving 2p13→p21. We thus hypothesised that a common gene locus may be responsible for GF in both the Brazilian family and the boy with the chromosome 2p duplication. We performed additional genetic linkage studies on the Brazilian family and molecular cytogenetic studies on the patient with the cytogenetic duplication to correlate more precisely the genetic interval of the HGF phenotype with the duplicated 2p interval. Additional linkage analysis of new family members resulted in refinement of the candidate region for HGF to an 8 Mb region. Molecular cytogenetic analysis of the 2p13→p21 duplication associated with GF showed that the duplicated region was proximal to the candidate interval for HGF. Thus, our results support the presence of two different gene loci on chromosome 2p that are involved in GF.


Keywords: gingival fibromatosis; chromosome duplication; chromosome 2 PMID:10507724

  19. Electron capture by a metastable ion in the collision Ar8+(2p53s)3P0,2+H2 at low velocity

    NASA Astrophysics Data System (ADS)

    Bliman, S.; Cornille, M.; Huber, B. A.; Nordgren, J.; Rubensson, J. E.

    2001-03-01

    Single-electron (SC) and double-electron capture (DC) in collisions of metastable Ar8+ ions with H2 have been studied by using X-VUV and Auger spectroscopy at 10 keV per charge. SC by the long-lived metastable ion Ar8+(2p53s)3P0.2 mostly populates inner-shell excited Na-like Ar7+**[(2p53s)3P,nl]2.4Lj levels with n=5, a small fraction going to n=4. With the use of radiative and Auger decay rates, the observed X-VUV and Auger spectra are analyzed and compared with the spectra obtained by other authors. It is shown that the stabilization of these core-excited states is both radiative and autoionizing. DC by the metastable projectile reveals the formation of triply excited Ar6+*** ions. They stabilize along two Auger decay steps: the first one gives a low-energy electron, associated with the decay to the intermediate continua Ar7+(2p53l3l'), while the second step-originating from these Ar7+(2p53l3l') levels-gives a higher-energy electron, characteristic of the decay to the only available continuum Ar8+(2p6)1S0.

  20. GluA2-dependent AMPA receptor endocytosis and the decay of early and late long-term potentiation: possible mechanisms for forgetting of short- and long-term memories.

    PubMed

    Hardt, Oliver; Nader, Karim; Wang, Yu-Tian

    2014-01-01

    The molecular processes involved in establishing long-term potentiation (LTP) have been characterized well, but the decay of early and late LTP (E-LTP and L-LTP) is poorly understood. We review recent advances in describing the mechanisms involved in maintaining LTP and homeostatic plasticity. We discuss how these phenomena could relate to processes that might underpin the loss of synaptic potentiation over time, and how they might contribute to the forgetting of short-term and long-term memories. We propose that homeostatic downscaling mediates the loss of E-LTP, and that metaplastic parameters determine the decay rate of L-LTP, while both processes require the activity-dependent removal of postsynaptic GluA2-containing AMPA receptors. PMID:24298143

  1. Synthetic, Spectroscopic, and Electrochemical Studies of the Isomerically-Rich [M(CO)(2)(P(2)P')X](+/0) (M = Mn, Re; X = Cl, Br; P(2)P' = eta(3)-Ph(2)P(CH(2))(2)P(Ph)(CH(2))(2)PPh(2)) System: Structural Characterization of a Novel Pair of Diastereoisomers of cis,mer-Re(CO)(2)(P(2)P')Cl.

    PubMed

    Bond, Alan M.; Colton, Ray; Gable, Robert W.; Mackay, Maureen F.; Walter, Jacky N.

    1997-03-12

    Reaction of Mn(CO)(5)X (X = Cl, Br) with Ph(2)P(CH(2))(2)P(Ph)(CH(2))(2)PPh(2) (P(2)P') in refluxing xylene led to the formation of isomerically pure cis,mer-Mn(CO)(2)(eta(3)-P(2)P')X. Cyclic voltammograms in dichloromethane (0.1 M Bu(4)NPF(6)) show a reversible one-electron oxidation (process 1, E(1/2) = 0.142 V) to give cis,mer-[Mn(CO)(2)(P(2)P')X](+). However, in acetone (0.1 M Bu(4)NPF(6)) at room temperature, process 1 is not reversible and an additional redox process 4 (E(1/2) = 0.048 V) is observed. Process 4 is not observed at low temperatures, and at higher temperatures in acetone it merges with process 1 and also a new reversible redox couple (process 5, E(1/2) = -0.411 V) appears. A combination of electrolyses, chemical oxidation, and subsequent reduction, coupled with IR and (31)P NMR spectroscopies and electrospray mass spectrometry (ESMS), is used to show that processes 1, 4, and 5 are all associated with redox and interconversion reactions of different isomers of Mn(CO)(2)(P(2)P')X and [Mn(CO)(2)(P(2)P')X](+). Other irreversible processes due to oxidation of the different isomers of [Mn(CO)(2)(P(2)P')X](+) are observed at very positive potentials. Reaction between Re(CO)(5)X and P(2)P' in refluxing mesitylene gives a soluble product and a small amount of precipitate. The major soluble product was identified as cis,mer-Re(CO)(2)(P(2)P')X, and the oxidative chemistry is similar to that of the manganese analogues. The precipitate consists of five compounds, one of which was cis,mer-Re(CO)(2)(P(2)P')X. The new compounds A-D were identified as follows: A is cis,mer-{Re(CO)(2)(P(2)P')X}(2), a dimeric species with bridging P(2)P' ligands. The spectroscopic data for B indicated that it was a form of cis,mer-Re(CO)(2)(P(2)P')X, but not the same as the major product. Compound C is cis,fac-Re(CO)(2)(P(2)P')X, and compound D was shown to be fac-[Re(CO)(3)(P(2)P')]X. The crystal structures of cis,mer-Re(CO)(2)(P(2)P')Cl(I) and cis,mer-Re(CO)(2)(P(2)P')Cl(II) show

  2. Ni2P Makes Application of the PtRu Catalyst Much Stronger in Direct Methanol Fuel Cells.

    PubMed

    Chang, Jinfa; Feng, Ligang; Liu, Changpeng; Xing, Wei

    2015-10-12

    PtRu is regarded as the best catalyst for direct methanol fuel cells, but the performance decay resulting from the loss of Ru seriously hinders commercial applications. Herein, we demonstrated that the presence of Ni2 P largely reduces Ru loss, which thus makes the application of PtRu much stronger in direct methanol fuel cells. Outstanding catalytic activity and stability were observed by cyclic voltammetry. Upon integrating the catalyst material into a practical direct methanol fuel cell, the highest maximum power density was achieved on the PtRu-Ni2P/C catalyst among the reference catalysts at different temperatures. A maximum power density of 69.9 mW cm(-2) at 30 °C was obtained on PtRu-Ni2P/C, which is even higher than the power density of the state-of-the-art commercial PtRu catalyst at 70 °C (63.1 mW cm(-2)). Moreover, decay in the performance resulting from Ru loss was greatly reduced owing to the presence of Ni2 P, which is indicative of very promising applications.

  3. Determinants of Default in P2P Lending

    PubMed Central

    2015-01-01

    This paper studies P2P lending and the factors explaining loan default. This is an important issue because in P2P lending individual investors bear the credit risk, instead of financial institutions, which are experts in dealing with this risk. P2P lenders suffer a severe problem of information asymmetry, because they are at a disadvantage facing the borrower. For this reason, P2P lending sites provide potential lenders with information about borrowers and their loan purpose. They also assign a grade to each loan. The empirical study is based on loans’ data collected from Lending Club (N = 24,449) from 2008 to 2014 that are first analyzed by using univariate means tests and survival analysis. Factors explaining default are loan purpose, annual income, current housing situation, credit history and indebtedness. Secondly, a logistic regression model is developed to predict defaults. The grade assigned by the P2P lending site is the most predictive factor of default, but the accuracy of the model is improved by adding other information, especially the borrower’s debt level. PMID:26425854

  4. Determinants of Default in P2P Lending.

    PubMed

    Serrano-Cinca, Carlos; Gutiérrez-Nieto, Begoña; López-Palacios, Luz

    2015-01-01

    This paper studies P2P lending and the factors explaining loan default. This is an important issue because in P2P lending individual investors bear the credit risk, instead of financial institutions, which are experts in dealing with this risk. P2P lenders suffer a severe problem of information asymmetry, because they are at a disadvantage facing the borrower. For this reason, P2P lending sites provide potential lenders with information about borrowers and their loan purpose. They also assign a grade to each loan. The empirical study is based on loans' data collected from Lending Club (N = 24,449) from 2008 to 2014 that are first analyzed by using univariate means tests and survival analysis. Factors explaining default are loan purpose, annual income, current housing situation, credit history and indebtedness. Secondly, a logistic regression model is developed to predict defaults. The grade assigned by the P2P lending site is the most predictive factor of default, but the accuracy of the model is improved by adding other information, especially the borrower's debt level.

  5. Protecting Data Privacy in Structured P2P Networks

    NASA Astrophysics Data System (ADS)

    Jawad, Mohamed; Serrano-Alvarado, Patricia; Valduriez, Patrick

    P2P systems are increasingly used for efficient, scalable data sharing. Popular applications focus on massive file sharing. However, advanced applications such as online communities (e.g., medical or research communities) need to share private or sensitive data. Currently, in P2P systems, untrusted peers can easily violate data privacy by using data for malicious purposes (e.g., fraudulence, profiling). To prevent such behavior, the well accepted Hippocratic database principle states that data owners should specify the purpose for which their data will be collected. In this paper, we apply such principles as well as reputation techniques to support purpose and trust in structured P2P systems. Hippocratic databases enforce purpose-based privacy while reputation techniques guarantee trust. We propose a P2P data privacy model which combines the Hippocratic principles and the trust notions. We also present the algorithms of PriServ, a DHT-based P2P privacy service which supports this model and prevents data privacy violation. We show, in a performance evaluation, that PriServ introduces a small overhead.

  6. Determinants of Default in P2P Lending.

    PubMed

    Serrano-Cinca, Carlos; Gutiérrez-Nieto, Begoña; López-Palacios, Luz

    2015-01-01

    This paper studies P2P lending and the factors explaining loan default. This is an important issue because in P2P lending individual investors bear the credit risk, instead of financial institutions, which are experts in dealing with this risk. P2P lenders suffer a severe problem of information asymmetry, because they are at a disadvantage facing the borrower. For this reason, P2P lending sites provide potential lenders with information about borrowers and their loan purpose. They also assign a grade to each loan. The empirical study is based on loans' data collected from Lending Club (N = 24,449) from 2008 to 2014 that are first analyzed by using univariate means tests and survival analysis. Factors explaining default are loan purpose, annual income, current housing situation, credit history and indebtedness. Secondly, a logistic regression model is developed to predict defaults. The grade assigned by the P2P lending site is the most predictive factor of default, but the accuracy of the model is improved by adding other information, especially the borrower's debt level. PMID:26425854

  7. The N2-P3 complex of the evoked potential and human performance

    NASA Technical Reports Server (NTRS)

    Odonnell, Brian F.; Cohen, Ronald A.

    1988-01-01

    The N2-P3 complex and other endogenous components of human evoked potential provide a set of tools for the investigation of human perceptual and cognitive processes. These multidimensional measures of central nervous system bioelectrical activity respond to a variety of environmental and internal factors which have been experimentally characterized. Their application to the analysis of human performance in naturalistic task environments is just beginning. Converging evidence suggests that the N2-P3 complex reflects processes of stimulus evaluation, perceptual resource allocation, and decision making that proceed in parallel, rather than in series, with response generation. Utilization of these EP components may provide insights into the central nervous system mechanisms modulating task performance unavailable from behavioral measures alone. The sensitivity of the N2-P3 complex to neuropathology, psychopathology, and pharmacological manipulation suggests that these components might provide sensitive markers for the effects of environmental stressors on the human central nervous system.

  8. Large-Scale Mini-Magnetosphere Plasma Propulsion (M2P2) Experiments

    NASA Technical Reports Server (NTRS)

    Winglee, R. M.; Slough, J.; Ziemba, T.; Euripides, P.; Adrian, M. L.; Gallagher, D.; Craven, P.; Tomlinson, W.; Cravens, J.; Burch, J.; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    Mini-Magnetosphere Plasma Propulsion (M2P2) is an innovative plasma propulsion system that has the potential to propel spacecraft at unprecedented speeds of 50 to 80 km per second with a low-power requirement of approx. 1 kW per 100 kg of payload and approx. 1 kg of neutral gas [fuel] consumption per day of acceleration. Acceleration periods from several days to a few months are envisioned. High specific impulse and efficiency are achieved through coupling of the spacecraft to the 400 km per second solar wind through an artificial magnetosphere. The mini-magnetosphere or inflated magnetic bubble is produced by the injection of cold dense plasma into a spacecraft-generated magnetic field envelope. Magnetic bubble inflation is driven by electromagnetic processes thereby avoiding the material and deployment problems faced by mechanical solar sail designs, Here, we present the theoretical design of M2P2 as well as initial results from experimental testing of an M2P2 prototype demonstrating: 1) inflation of the dipole magnetic field geometry through the internal injection of cold plasma; and 2) deflection of and artificial solar wind by the prototype M2P2 system. In addition, we present plans for direct laboratory measurement of thrust imparted to a prototype M2P2 by an artificial solar wind during the summer of 2001.

  9. Monitoring autophagic flux using Ref(2)P, the Drosophila p62 ortholog.

    PubMed

    DeVorkin, Lindsay; Gorski, Sharon M

    2014-09-02

    Human p62, also known as Sequestome-1 (SQSTM1), is a multifunctional scaffold protein that contains many domains, including a Phox/Bem1P (PB1) multimerization domain, an ubiquitin-associated (UBA) domain, and a light chain 3 (LC3) recognition sequence. p62 binds ubiquitinated proteins and targets them for degradation by the proteasome. In addition, p62 directly binds LC3; this may serve as a mechanism to deliver ubiquitinated proteins for degradation by autophagy. During this process, p62 itself is degraded. The inhibition of autophagy leads to the accumulation of p62, indicating that it can be used as a marker of autophagic flux. Ref(2)P (refractory to sigma P), the Drosophila ortholog of p62, is also required for the formation of ubiquitinated protein aggregates. Ref(2)P contains a putative LC3-interacting region, and genetic inhibition of autophagy in Drosophila leads to the accumulation of Ref(2)P protein levels. Thus, like p62, Ref(2)P may serve as a marker of autophagic flux. Here we provide two procedures to examine Ref(2)P protein levels in Drosophila ovaries.

  10. Large-Scale Mini-Magnetosphere Plasma Propulsion (M2P2) Experiments

    NASA Technical Reports Server (NTRS)

    Winglee, R. M.; Slough, J.; Ziemba, T.; Euripides, P.; Gallagher, D.; Craven, P.; Adrian, M. L.; Tomlinson, W.; Cravens, J.; Burch, J.; Rose, M. Franklin (Technical Monitor)

    2001-01-01

    Mini-Magnetosphere Plasma Propulsion (M2P2) is an innovative plasma propulsion system that has the potential to propel spacecraft at unprecedented speeds of 50 to 80 km/s, with a low power requirement of approx. 1 kW per 100 kg of payload and -1 kg of neutral gas [fuel] consumption per day of acceleration. Acceleration periods from several days to a few months are envisioned. High specific impulse and efficiency are achieved through coupling of the spacecraft to the 400 km/s. solar wind through an artificial magnetosphere. The mini-magnetosphere or inflated magnetic bubble is produced by the injection of cold dense plasma into a spacecraft-generated magnetic field envelope. Magnetic bubble inflation is driven by electromagnetic processes thereby avoiding the material and deployment problems faced by mechanical solar sail designs. Here, we present the theoretical design of M2P2 as well as initial results from experimental testing of an M2P2 prototype demonstrating: 1) inflation of the dipole magnetic field geometry through the internal injection of cold plasma; and 2) deflection of and artificial solar wind by the prototype M2P2 system. In addition, we present plans for direct laboratory measurement of thrust imparted to a prototype M2P2 by an artificial solar wind during the summer of 2001.

  11. The Clathrin Adaptor Gga2p Is a Phosphatidylinositol 4-phosphate Effector at the Golgi Exit

    PubMed Central

    Demmel, Lars; Gravert, Maike; Ercan, Ebru; Habermann, Bianca; Müller-Reichert, Thomas; Kukhtina, Viktoria; Haucke, Volker; Baust, Thorsten; Sohrmann, Marc; Kalaidzidis, Yannis; Klose, Christian; Beck, Mike; Peter, Matthias

    2008-01-01

    Phosphatidylinositol 4-phosphate (PI(4)P) is a key regulator of membrane transport required for the formation of transport carriers from the trans-Golgi network (TGN). The molecular mechanisms of PI(4)P signaling in this process are still poorly understood. In a search for PI(4)P effector molecules, we performed a screen for synthetic lethals in a background of reduced PI(4)P and found the gene GGA2. Our analysis uncovered a PI(4)P-dependent recruitment of the clathrin adaptor Gga2p to the TGN during Golgi-to-endosome trafficking. Gga2p recruitment to liposomes is stimulated both by PI(4)P and the small GTPase Arf1p in its active conformation, implicating these two molecules in the recruitment of Gga2p to the TGN, which ultimately controls the formation of clathrin-coated vesicles. PI(4)P binding occurs through a phosphoinositide-binding signature within the N-terminal VHS domain of Gga2p resembling a motif found in other clathrin interacting proteins. These data provide an explanation for the TGN-specific membrane recruitment of Gga2p. PMID:18287542

  12. Fragrance material review on 2-(p-tolyloxy)ethyl acetate.

    PubMed

    McGinty, D; Letizia, C S; Api, A M

    2012-09-01

    A toxicologic and dermatologic review of 2-(p-tolyloxy)ethyl acetate when used as a fragrance ingredient is presented. 2-(p-tolyloxy)ethyl acetate is a member of the fragrance structural group aryl alkyl alcohol simple acid esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-(p-tolyloxy)ethyl acetate were evaluated, then summarized, and includes physical properties data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.

  13. Fragrance material review on 2-(p-tolyloxy)ethyl acetate.

    PubMed

    McGinty, D; Letizia, C S; Api, A M

    2012-09-01

    A toxicologic and dermatologic review of 2-(p-tolyloxy)ethyl acetate when used as a fragrance ingredient is presented. 2-(p-tolyloxy)ethyl acetate is a member of the fragrance structural group aryl alkyl alcohol simple acid esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-(p-tolyloxy)ethyl acetate were evaluated, then summarized, and includes physical properties data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances. PMID:22414652

  14. Faraday effect in Sn2P2S6 crystals.

    PubMed

    Krupych, Oleh; Adamenko, Dmytro; Mys, Oksana; Grabar, Aleksandr; Vlokh, Rostyslav

    2008-11-10

    We have revealed a large Faraday rotation in tin thiohypodiphosphate (Sn(2)P(2)S(6)) crystals, which makes this material promising for magneto-optics. The effective Faraday tensor component and the Verdet constant for the direction of the optic axis have been determined by measuring the pure Faraday rotation in Sn(2)P(2)S(6) crystals with both the single-ray and small-angular polarimetric methods at the normal conditions and a wavelength of 632.8 nm. The effective Verdet constant is found to be equal to 115 rad/T x m.

  15. Ring current proton decay by charge exchange

    NASA Technical Reports Server (NTRS)

    Smith, P. H.; Hoffman, R. A.; Fritz, T.

    1975-01-01

    Explorer 45 measurements during the recovery phase of a moderate magnetic storm have confirmed that the charge exchange decay mechanism can account for the decay of the storm-time proton ring current. Data from the moderate magnetic storm of 24 February 1972 was selected for study since a symmetrical ring current had developed and effects due to asymmetric ring current losses could be eliminated. It was found that after the initial rapid decay of the proton flux, the equatorially mirroring protons in the energy range 5 to 30 keV decayed throughout the L-value range of 3.5 to 5.0 at the charge exchange decay rate calculated by Liemohn. After several days of decay, the proton fluxes reached a lower limit where an apparent equilibrium was maintained, between weak particle source mechanisms and the loss mechanisms, until fresh protons were injected into the ring current region during substorms. While other proton loss mechanisms may also be operating, the results indicate that charge exchange can entirely account for the storm-time proton ring current decay, and that this mechanism must be considered in all studies involving the loss of proton ring current particles.

  16. Hal2p functions in Bdf1p-involved salt stress response in Saccharomyces cerevisiae.

    PubMed

    Chen, Lei; Liu, Liangyu; Wang, Mingpeng; Fu, Jiafang; Zhang, Zhaojie; Hou, Jin; Bao, Xiaoming

    2013-01-01

    The Saccharomyces cerevisiae Bdf1p associates with the basal transcription complexes TFIID and acts as a transcriptional regulator. Lack of Bdf1p is salt sensitive and displays abnormal mitochondrial function. The nucleotidase Hal2p detoxifies the toxic compound 3' -phosphoadenosine-5'-phosphate (pAp), which blocks the biosynthesis of methionine. Hal2p is also a target of high concentration of Na(+). Here, we reported that HAL2 overexpression recovered the salt stress sensitivity of bdf1Δ. Further evidence demonstrated that HAL2 expression was regulated indirectly by Bdf1p. The salt stress response mechanisms mediated by Bdf1p and Hal2p were different. Unlike hal2Δ, high Na(+) or Li(+) stress did not cause pAp accumulation in bdf1Δ and methionine supplementation did not recover its salt sensitivity. HAL2 overexpression in bdf1Δ reduced ROS level and improved mitochondrial function, but not respiration. Further analyses suggested that autophagy was apparently defective in bdf1Δ, and autophagy stimulated by Hal2p may play an important role in recovering mitochondrial functions and Na(+) sensitivity of bdf1Δ. Our findings shed new light towards our understanding about the molecular mechanism of Bdf1p-involved salt stress response in budding yeast.

  17. Measurement and Analysis of P2P IPTV Program Resource

    PubMed Central

    Chen, Xingshu; Wang, Haizhou; Zhang, Qi

    2014-01-01

    With the rapid development of P2P technology, P2P IPTV applications have received more and more attention. And program resource distribution is very important to P2P IPTV applications. In order to collect IPTV program resources, a distributed multi-protocol crawler is proposed. And the crawler has collected more than 13 million pieces of information of IPTV programs from 2009 to 2012. In addition, the distribution of IPTV programs is independent and incompact, resulting in chaos of program names, which obstructs searching and organizing programs. Thus, we focus on characteristic analysis of program resources, including the distributions of length of program names, the entropy of the character types, and hierarchy depth of programs. These analyses reveal the disorderly naming conventions of P2P IPTV programs. The analysis results can help to purify and extract useful information from chaotic names for better retrieval and accelerate automatic sorting of program and establishment of IPTV repository. In order to represent popularity of programs and to predict user behavior and popularity of hot programs over a period, we also put forward an analytical model of hot programs. PMID:24772008

  18. Measurement and analysis of P2P IPTV program resource.

    PubMed

    Wang, Wenxian; Chen, Xingshu; Wang, Haizhou; Zhang, Qi; Wang, Cheng

    2014-01-01

    With the rapid development of P2P technology, P2P IPTV applications have received more and more attention. And program resource distribution is very important to P2P IPTV applications. In order to collect IPTV program resources, a distributed multi-protocol crawler is proposed. And the crawler has collected more than 13 million pieces of information of IPTV programs from 2009 to 2012. In addition, the distribution of IPTV programs is independent and incompact, resulting in chaos of program names, which obstructs searching and organizing programs. Thus, we focus on characteristic analysis of program resources, including the distributions of length of program names, the entropy of the character types, and hierarchy depth of programs. These analyses reveal the disorderly naming conventions of P2P IPTV programs. The analysis results can help to purify and extract useful information from chaotic names for better retrieval and accelerate automatic sorting of program and establishment of IPTV repository. In order to represent popularity of programs and to predict user behavior and popularity of hot programs over a period, we also put forward an analytical model of hot programs.

  19. Stick slip, charge separation and decay

    USGS Publications Warehouse

    Lockner, D.A.; Byerlee, J.D.; Kuksenko, V.S.; Ponomarev, A.V.

    1986-01-01

    Measurements of charge separation in rock during stable and unstable deformation give unexpectedly large decay times of 50 sec. Time-domain induced polarization experiments on wet and dry rocks give similar decay times and suggest that the same decay mechanisms operate in the induced polarization response as in the relaxation of charge generated by mechanical deformation. These large decay times are attributed to electrochemical processes in the rocks, and they require low-frequency relative permittivity to be very large, in excess of 105. One consequence of large permittivity, and therefore long decay times, is that a significant portion of any electrical charge generated during an earthquake can persist for tens or hundreds of seconds. As a result, electrical disturbances associated with earthquakes should be observable for these lengths of time rather than for the milliseconds previously suggested. ?? 1986 Birka??user Verlag.

  20. Evidence for the decay

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Cartelle, P. Alvarez; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreassen, R.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Gutierrez, O. Aquines; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Balagura, V.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Bauer, Th.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjørnstad, P. M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N. H.; Brown, H.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Callot, O.; Calvi, M.; Gomez, M. Calvo; Camboni, A.; Campana, P.; Perez, D. Campora; Caponio, F.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Akiba, K. Carvalho; Casse, G.; Cassina, L.; Garcia, L. Castillo; Cattaneo, M.; Cauet, Ch.; Cenci, R.; Charles, M.; Charpentier, Ph.; Cheung, S.-F.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Vidal, X. Cid; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coca, C.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Counts, I.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Torres, M. Cruz; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Suárez, A. Dosil; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Esen, S.; Falabella, A.; Färber, C.; Farinelli, C.; Farley, N.; Farry, S.; Ferguson, D.; Albor, V. Fernandez; Rodrigues, F. Ferreira; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Torreira, A. Gallas; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; Garofoli, J.; Tico, J. Garra; Garrido, L.; Gaspar, C.; Gauld, R.; Gavardi, L.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Giani', S.; Gibson, V.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Gotti, C.; Gándara, M. Grabalosa; Diaz, R. Graciani; Cardoso, L. A. Granado; Graugés, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Hafkenscheid, T. W.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; Hartmann, T.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Morata, J. A. Hernando; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Hunt, P.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jans, E.; Jaton, P.; Jawahery, A.; Jezabek, M.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kaballo, M.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Kelsey, M.; Kenyon, I. R.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Liu, G.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lopez-March, N.; Lowdon, P.; Lu, H.; Lucchesi, D.; Luo, H.; Luppi, E.; Lupton, O.; Machefert, F.; Machikhiliyan, I. V.; Maciuc, F.; Maev, O.; Malde, S.; Manca, G.; Mancinelli, G.; Manzali, M.; Maratas, J.; Marchand, J. F.; Marconi, U.; Benito, C. Marin; Marino, P.; Märki, R.; Marks, J.; Martellotti, G.; Martens, A.; Sánchez, A. Martín; Martinelli, M.; Santos, D. Martinez; Vidal, F. Martinez; Tostes, D. Martins; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; McSkelly, B.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D. A.; Minard, M.-N.; Rodriguez, J. Molina; Monteil, S.; Moran, D.; Morandin, M.; Morawski, P.; Mordà, A.; Morello, M. J.; Moron, J.; Mountain, R.; Muheim, F.; Müller, K.; Muresan, R.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, G.; Orlandea, M.; Goicochea, J. M. Otalora; Owen, P.; Oyanguren, A.; Pal, B. K.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Pappalardo, L.; Parkes, C.; Parkinson, C. J.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrignani, C.; Alvarez, A. Pazos; Pearce, A.; Pellegrino, A.; Altarelli, M. Pepe; Perazzini, S.; Trigo, E. Perez; Perret, P.; Perrin-Terrin, M.; Pescatore, L.; Pesen, E.; Petridis, K.; Petrolini, A.; Olloqui, E. Picatoste; Pietrzyk, B.; Pilař, T.; Pinci, D.; Pistone, A.; Playfer, S.; Casasus, M. Plo; Polci, F.; Poluektov, A.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Navarro, A. Puig; Punzi, G.; Qian, W.; Rachwal, B.; Rademacker, J. H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Reichert, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, A.; Rinnert, K.; Molina, V. Rives; Romero, D. A. Roa; Robbe, P.; Roberts, D. A.; Rodrigues, A. B.; Rodrigues, E.; Perez, P. Rodriguez; Roiser, S.; Romanovsky, V.; Vidal, A. Romero; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruffini, F.; Ruiz, H.; Valls, P. Ruiz; Sabatino, G.; Silva, J. J. Saborido; Sagidova, N.; Sail, P.; Saitta, B.; Guimaraes, V. Salustino; Sedes, B. Sanmartin; Santacesaria, R.; Rios, C. Santamarina; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Senderowska, K.; Sepp, I.; Serra, N.; Serrano, J.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, O.; Shevchenko, V.; Shires, A.; Sidorov, F.; Coutinho, R. Silva; Simi, G.; Sirendi, M.; Skidmore, N.; Skwarnicki, T.; Smith, N. A.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; De Paula, B. Souza; Spaan, B.; Sparkes, A.; Spinella, F.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Subbiah, V. K.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szilard, D.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M. T.; Tresch, M.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Garcia, M. Ubeda; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vallier, A.; Gomez, R. Vazquez; Regueiro, P. Vazquez; Sierra, C. Vázquez; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; Voss, H.; de Vries, J. A.; Waldi, R.; Wallace, C.; Wallace, R.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiedner, D.; Wilkinson, G.; Williams, M. P.; Williams, M.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W. C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zvyagin, A.

    2014-05-01

    Evidence is presented for the decay using proton-proton collision data, corresponding to an integrated luminosity of 3 fb-1, collected with the LHCb detector. A signal yield of 32 ± 8 decays is found with a significance of 4.5 standard deviations. The ratio of the branching fraction of the decay to that of the decay is measured to be where the first uncertainty is statistical and the second is systematic. [Figure not available: see fulltext.

  1. Interatomic Coulombic decay in nanodroplets

    NASA Astrophysics Data System (ADS)

    Sisourat, Nicolas

    2014-05-01

    Interatomic (molecular) Coulombic decay (ICD) is an ultrafast non-radiative electronic decay process for excited atoms or molecules embedded in a chemical environment. Via ICD, the excited system can get rid of the excess energy, which is transferred to one of the neighbors and ionize it. ICD produces two charged particles next to each other and thus leads to Coulomb explosion. Kinetic energy distribution of the ionic fragments gives information on the dynamics of the decay process. From the theoretical point of view general quantum mechanical equations for describing the decay processes and the subsequent fragmentations are known but are only applicable for rather small systems. During the presentation, a semiclassical approach for modeling ICD and the subsequent fragmentations will be presented. This approach involves a classical treatment for the nuclear motion while retaining a quantum description for the electron dynamics. Such approach has low computational costs and can be used to study much larger systems. Comparison of the results from semiclassical and from quantum mechanical calculations will be shown for simple systems, demonstrating the good performance of the semiclassical method. Results on ICD in nanodroplets will finally be reported.

  2. Derivatives of benzimidazole: vasodilator activity of 2-(p-chloro-alpha-hydroxybenzyl)-benzimidazole hydrochloride. Preliminary study.

    PubMed

    Demenge, P; Carraz, G; Luu Duc, C; Silice, C

    1979-01-01

    The effects of 2-(p-chloro-alpha-hydroxybenzyl)-benzimidazole hydrochloride (HBBPC) have been studied in the rabbit and rat. Most of these studies were performed comparatively with reference vasodilators and papaverine. HBBPC vasodilator activity is nearly the same as that of papaverine in the isolated rabbit ear. The characteristic of the vasoactive action of HBBPC seems to reside in its duration. The mechanism of action of HBBPC seems of peripheral type, that is to say it acts on the vascular smooth muscle.

  3. K2P potassium channels, mysterious and paradoxically exciting.

    PubMed

    Goldstein, Steve A N

    2011-08-01

    New evidence reveals that the common electrolyte disorder hypokalemia can induce K2P1 channels that are normally selective for K+ to break the rules and conduct Na+. This defiant behavior leads to paradoxical depolarization of many cells in the heart, increasing the risk for lethal arrhythmia. The new research resolves a mystery uncovered 50 years ago and bestows an array of new riddles. Here, I discuss how K2P1 might achieve this alchemy--through stable residence of the K+ selectivity filter in a Na+-conductive state between its open and C-inactive configurations--and predict that other K+ channels and environmental stimuli will be discovered to produce the same excitatory misconduct. PMID:21868351

  4. Supporting seamless mobility for P2P live streaming.

    PubMed

    Kim, Eunsam; Kim, Sangjin; Lee, Choonhwa

    2014-01-01

    With advent of various mobile devices with powerful networking and computing capabilities, the users' demand to enjoy live video streaming services such as IPTV with mobile devices has been increasing rapidly. However, it is challenging to get over the degradation of service quality due to data loss caused by the handover. Although many handover schemes were proposed at protocol layers below the application layer, they inherently suffer from data loss while the network is being disconnected during the handover. We therefore propose an efficient application-layer handover scheme to support seamless mobility for P2P live streaming. By simulation experiments, we show that the P2P live streaming system with our proposed handover scheme can improve the playback continuity significantly compared to that without our scheme.

  5. Supporting Seamless Mobility for P2P Live Streaming

    PubMed Central

    Kim, Eunsam; Kim, Sangjin; Lee, Choonhwa

    2014-01-01

    With advent of various mobile devices with powerful networking and computing capabilities, the users' demand to enjoy live video streaming services such as IPTV with mobile devices has been increasing rapidly. However, it is challenging to get over the degradation of service quality due to data loss caused by the handover. Although many handover schemes were proposed at protocol layers below the application layer, they inherently suffer from data loss while the network is being disconnected during the handover. We therefore propose an efficient application-layer handover scheme to support seamless mobility for P2P live streaming. By simulation experiments, we show that the P2P live streaming system with our proposed handover scheme can improve the playback continuity significantly compared to that without our scheme. PMID:24977171

  6. Pure P2P mediation system: A mappings discovery approach

    NASA Astrophysics Data System (ADS)

    selma, El yahyaoui El idrissi; Zellou, Ahmed; Idri, Ali

    2015-02-01

    The information integration systems consist in offering a uniform interface to provide access to a set of autonomous and distributed information sources. The most important advantage of this system is that it allows users to specify what they want, rather than thinking about how to get the responses. The works realized in this area have particular leads to two major classes of integration systems: the mediation systems based on the paradigm mediator / adapter and peer to peer systems (P2P). The combination of both systems has led to a third type; is the mediation P2P systems. The P2P systems are large-scale systems, self-organized and distributed. They allow the resource management in a completely decentralized way. However, the integration of structured information sources, heterogeneous and distributed proves to be a complex problem. The objective of this work is to propose an approach to resolve conflicts and establish a mapping between the heterogeneous elements. This approach is based on clustering; the latter is to group similar Peers that share common information in the same subnet. Thus, to facilitate the heterogeneity, we introduced three additional layers of our hierarchy of peers: internal schema, external schema and Schema directory peer. We used linguistic techniques, and precisely the name correspondence technique, that is based on the similarity of names to propose a correspondence.

  7. A Measurement of g2p at Low Q2

    NASA Astrophysics Data System (ADS)

    Cummings, M.

    2016-02-01

    Jefferson Lab has been at the forefront of a program to study the polarized structure of nucleons using electron scattering. Measurements of the spin dependent structure functions, g1 and g2, have proven to be powerful tools in testing and understanding QCD. The neutron structure function g2n has been measured extensively in Hall A at Jefferson Lab over a wide range of Q2, but data for g2p remains scarce. This docment will discuss the g2p experiment, which ran in Hall A at Jefferson Lab in the spring of 2012, and will provide the first measurement of g2p in the resonance region; covering 0.02 < Q2 < 0.2 GeV2. The 0th moment of g2 provides a test of the Burkhardt-Cottingham sum rule, which states that the integral of g2 over the Bjorken scaling variable x goes to zero. This sum rule, valid for all values of Q2, has been satisfied for the neutron, but a violation is suggested for the proton at high Q2. The 2nd moment allows for a benchmark test of χPT at low Q2. Specifically, the behavior of the longitudinally-transverse spin polarizability (δLT), as χPT calculations of this quantity deviate significantly from the measured neutron data. This document will discuss the current status of the analysis along with preliminary results.

  8. Promoter Methylation Status Modulate the Expression of Tumor Suppressor (RbL2/p130) Gene in Breast Cancer

    PubMed Central

    Ullah, Farman; Khan, Taimoor; Ali, Nawab; Malik, Faraz Arshad; Kayani, Mahmood Akhtar; Shah, Syed Tahir Abbas; Saeed, Muhammad

    2015-01-01

    Background Aberrant expression of tumor suppressor genes may correspond to the abnormal cell development and tumorigenesis. Rbl2/p130, a member of retinoblastoma family of proteins, has growth suppressive properties. Numerous studies reported de-regulation of Rbl2/p130 in various types of cancer as a consequence of a number of genetic alterations. However, role of epigenetic mechanisms like DNA methylation in Rbl2/p130 expression remains elusive. Methods In the current study, 76 breast cancer tumors along with normal tissues (n = 76), blood (n = 76) of respective individuals and control blood (n = 50) were analyzed. Rbl2/p130 expression was analyzed by quantitative real time PCR (syber green method). Promoter methylation status was studied through methylation specific PCR of bisulfite converted genomic DNA. Data was analyzed using various statistical tests. Results We report significantly reduced Rbl2/p130 expression (P = 0.001) in tumors tissues as compared to control samples. Similarly, Rbl2/p130 expression varies with age and disease stages (P = 0.022), which suggest its involvement in tumor progression. Aberrant promoter methylation (Δmeth) was found in almost all the diseased samples and that was significantly different (P<0.001) with control samples. Similarly, methylation status varies significantly with tumor progression stages (P = 0.022). Hyper-methylation was observed at -1, +3, +15 and +75 of Rbl2/p130 promoter flanking around the TSS. Statistical analysis revealed that Rbl2/p130 expression negatively correlates to its promoter methylation (r = -0.412) in tumor tissues. Our results reflect an epigenetic regulation of Rbl2/p130 expression in breast cancer. This highlights the importance of Rbl2/p130 promoter methylation in breast cancer pathogenesis. PMID:26271034

  9. Uncovering the behavior of Hf2Te2P and the candidate Dirac metal Zr2Te2P

    NASA Astrophysics Data System (ADS)

    Chen, K.-W.; Das, S.; Rhodes, D.; Memaran, S.; Besara, T.; Siegrist, T.; Manousakis, E.; Balicas, L.; Baumbach, R. E.

    2016-04-01

    Results are reported for single crystal specimens of Hf2Te2P and compared to its structural analogue Zr2Te2P, which was recently proposed to be a potential reservoir for Dirac physics [1]. Both materials are produced using the iodine vapor phase transport method and the resulting crystals are exfoliable. The bulk electrical transport and thermodynamic properties indicate Fermi liquid behavior at low temperature for both compounds. Quantum oscillations are observed in magnetization measurements for fields applied parallel but not perpendicular to the c-axis, suggesting that the Fermi surfaces are quasi-two dimensional. Frequencies are determined from quantum oscillations for several parts of the Fermi surfaces. Lifshitz-Kosevich fits to the temperature dependent amplitudes of the oscillations reveal small effective masses, with a particularly small value {{m}\\ast}=0.046{{m}0} for the α branch of Zr2Te2P. Electronic structure calculations are in good agreement with quantum oscillation results and illustrate the effect of a stronger spin-orbit interaction going from Zr to Hf. These results suggest that by using appropriate tuning parameters this class of materials may deepen the pool of novel Dirac phenomena.

  10. O2, pH, and redox potential microprofiles around Potamogeton malaianus measured using microsensors.

    PubMed

    Dong, Bin; Han, Ruiming; Wang, Guoxiang; Cao, Xun

    2014-01-01

    This study aimed to elucidate the effects of periphyton on the microprofiles of oxygen (O2), pH, and oxidation-reduction potential around the stems and leaves of a submerged macrophyte Potamogeton malaianus and on the plant growth in the eutrophic shallow Taihu Lake, China. The microprofiles were measured using a motorized microprofiling system equipped with microsensors. The leaf age of the macrophyte and periphyton exerted significant effects on the microprofiles of O2, pH, and oxidation-reduction potential. O2 concentration and pH increased whereas the oxidation-reduction potential decreased with decreasing distance to the stem/leaf surface. The fluctuation amplitudes of O2, pH, and oxidation-reduction potential were the largest in the microprofiles of mature leaves and the lowest in senescent leaves. The periphyton increased the thickness of the broad diffusive boundary layer and fluctuation amplitudes of O2, pH, and oxidation-reduction potential. When the periphyton was removed, the thickness of the broad diffusive boundary layer in the microprofiles of stems, senescent leaves, and mature leaves reduced by 29.0%, 49.72%, and 70.34%, and the O2, pH, and oxidation-reduction potential fluctuation amplitudes also declined accordingly. Our results suggest that a thick periphyton exerted negative effects on the growth of macrophytes by providing extensive shading and creating a barrier that hindered the transport of dissolved substances such as O2, and led to premature decline in macrophytes in the eutrophic Taihu Lake. The consequent implications can help to elucidate the control mechanism of the broad diffusive boundary layer around macrophytes on nutrient cycling in eutrophic waters and to better understand the role of this layer in the Taihu Lake and other similar eutrophic waters. PMID:25004129

  11. O2, pH, and Redox Potential Microprofiles around Potamogeton malaianus Measured Using Microsensors

    PubMed Central

    Dong, Bin; Han, Ruiming; Wang, Guoxiang; Cao, Xun

    2014-01-01

    This study aimed to elucidate the effects of periphyton on the microprofiles of oxygen (O2), pH, and oxidation-reduction potential around the stems and leaves of a submerged macrophyte Potamogeton malaianus and on the plant growth in the eutrophic shallow Taihu Lake, China. The microprofiles were measured using a motorized microprofiling system equipped with microsensors. The leaf age of the macrophyte and periphyton exerted significant effects on the microprofiles of O2, pH, and oxidation-reduction potential. O2 concentration and pH increased whereas the oxidation-reduction potential decreased with decreasing distance to the stem/leaf surface. The fluctuation amplitudes of O2, pH, and oxidation-reduction potential were the largest in the microprofiles of mature leaves and the lowest in senescent leaves. The periphyton increased the thickness of the broad diffusive boundary layer and fluctuation amplitudes of O2, pH, and oxidation-reduction potential. When the periphyton was removed, the thickness of the broad diffusive boundary layer in the microprofiles of stems, senescent leaves, and mature leaves reduced by 29.0%, 49.72%, and 70.34%, and the O2, pH, and oxidation-reduction potential fluctuation amplitudes also declined accordingly. Our results suggest that a thick periphyton exerted negative effects on the growth of macrophytes by providing extensive shading and creating a barrier that hindered the transport of dissolved substances such as O2, and led to premature decline in macrophytes in the eutrophic Taihu Lake. The consequent implications can help to elucidate the control mechanism of the broad diffusive boundary layer around macrophytes on nutrient cycling in eutrophic waters and to better understand the role of this layer in the Taihu Lake and other similar eutrophic waters. PMID:25004129

  12. β -Decay Half-Lives of 110 Neutron-Rich Nuclei across the N =82 Shell Gap: Implications for the Mechanism and Universality of the Astrophysical r Process

    NASA Astrophysics Data System (ADS)

    Lorusso, G.; Nishimura, S.; Xu, Z. Y.; Jungclaus, A.; Shimizu, Y.; Simpson, G. S.; Söderström, P.-A.; Watanabe, H.; Browne, F.; Doornenbal, P.; Gey, G.; Jung, H. S.; Meyer, B.; Sumikama, T.; Taprogge, J.; Vajta, Zs.; Wu, J.; Baba, H.; Benzoni, G.; Chae, K. Y.; Crespi, F. C. L.; Fukuda, N.; Gernhäuser, R.; Inabe, N.; Isobe, T.; Kajino, T.; Kameda, D.; Kim, G. D.; Kim, Y.-K.; Kojouharov, I.; Kondev, F. G.; Kubo, T.; Kurz, N.; Kwon, Y. K.; Lane, G. J.; Li, Z.; Montaner-Pizá, A.; Moschner, K.; Naqvi, F.; Niikura, M.; Nishibata, H.; Odahara, A.; Orlandi, R.; Patel, Z.; Podolyák, Zs.; Sakurai, H.; Schaffner, H.; Schury, P.; Shibagaki, S.; Steiger, K.; Suzuki, H.; Takeda, H.; Wendt, A.; Yagi, A.; Yoshinaga, K.

    2015-05-01

    The β -decay half-lives of 110 neutron-rich isotopes of the elements from Rb 37 to Sn 50 were measured at the Radioactive Isotope Beam Factory. The 40 new half-lives follow robust systematics and highlight the persistence of shell effects. The new data have direct implications for r -process calculations and reinforce the notion that the second (A ≈130 ) and the rare-earth-element (A ≈160 ) abundance peaks may result from the freeze-out of an (n ,γ )⇄(γ ,n ) equilibrium. In such an equilibrium, the new half-lives are important factors determining the abundance of rare-earth elements, and allow for a more reliable discussion of the r process universality. It is anticipated that universality may not extend to the elements Sn, Sb, I, and Cs, making the detection of these elements in metal-poor stars of the utmost importance to determine the exact conditions of individual r -process events.

  13. Widely available active sites on Ni2P for electrochemical hydrogen evolution--insights from first principles calculations.

    PubMed

    Hansen, Martin H; Stern, Lucas-Alexandre; Feng, Ligang; Rossmeisl, Jan; Hu, Xile

    2015-04-28

    We present insights into the mechanism and the active site for hydrogen evolution on nickel phosphide (Ni2P). Ni2P was recently discovered to be a very active non-precious hydrogen evolution catalyst. Current literature attributes the activity of Ni2P to a particular site on the (0001) facet. In the present study, using Density Functional Theory (DFT) calculations, we show that several widely available low index crystal facets on Ni2P have better properties for a high catalytic activity. DFT calculations were used to identify moderately bonding nickel bridge sites and nickel hollow sites for hydrogen adsorption and to calculate barriers for the Tafel pathway. The investigated surfaces in this study were the (101̅0), (1̅1̅20), (112̅0), (112̅1) and (0001) facets of the hexagonal Ni2P crystal. In addition to the DFT results, we present experiments on Ni2P nanowires growing along the 〈0001〉 direction, which are shown as efficient hydrogen evolution catalysts. The experimental results add these nanowires to a variety of different morphologies of Ni2P, which are all active for HER. PMID:25812670

  14. Rare Decays at LHCb

    NASA Astrophysics Data System (ADS)

    Hall, Sam

    2014-04-01

    Rare decays of beauty and charm hadrons provide an effective method of testing the Standard Model and probing possible new physics scenarios. The LHCb experiment has published a variety of interesting results in this field, some of which are presented here. In particular the measurements of the branching fractions of B(s)0 → μ+μ- which, in combination with CMS, resulted in the first observation of the Bs0 → μ+μ- decay. Other topics include searches for the rare decay D0 → μ+μ-, the lepton flavour violating decays B(s)0 → e±μ∓, and the observation of the ψ(4160) resonance in the region of low recoil in B+ → K+μ+μ- decay. New results on the angular analysis of the decay B0 → K*0μ+μ- with form factor independent observables are also shown.

  15. Precision lifetime measurements of the 2p levels in lithium

    SciTech Connect

    Berry, H.G.; Kurtz, C.; Tanner, C.E.

    1995-08-01

    These measurements are motivated by the theoretical challenges posed by lithium. The three-electron lithium atom is one of the simplest atomic systems with which to test atomic structure calculations. Recently, there were several ab initio calculations of the lithium 2s-2p oscillator strengths, which agree to 0.15%. However, the theoretical results differ by 5 sigma from the precise fast-beam-laser lifetime measurement of Gaupp and Andra (Berlin). Hence the need for a new independent and precise measurement. Improvements were added to the fast beam laser techniques developed for cesium in order to measure the lithium 2p state lifetime. Although the technique is similar to that of cesium, the lithium atom presents a few new complications. Since the atom is lighter, it travels more quickly through the interaction and detection regions. Therefore, the 670 nm wavelength requires a dye laser to produce sufficient intensity to populate the excited state. Unfortunately, the intensity of the dye laser is inherently less stable than that of a diode laser. Another complication is that the ion-beam intensity is much more sensitive to fluctuations in the accelerating voltage. Two detectors were added: one to monitor the ion-beam intensity, and the other to monitor the laser power. With the information from the additional detectors, a new data analysis scheme was developed. Sufficient data were taken to evaluate the benefits of the new detectors. No additional work is planned at Argonne for this experiment.

  16. Spectrometer Optics Calibration for Jefferson Lab g2^p Experiment

    NASA Astrophysics Data System (ADS)

    Gu, Chao

    2013-04-01

    The proton spin-dependent structure function g2^p in the resonance region has been measured in a recent experiment at Jefferson Lab's Hall A. The goal of this experiment is to determine the g2^p structure function in the Q^2 region of 0.02-0.20 GeV^2 by using a transversely polarized NH3 target. The Hall A High Resolution Spectrometers (HRS) were used to provide an inclusive measurement of scattered electrons at 5.69^o. A pair of septum magnets were used to bend the 5.69^o scatted electrons into the 12.5^o spectrometers. A full optics calibration of the spectrometer is required to extract the kinematic quantities at the interaction vertex. However, the calibration procedure is challenging due to the complications from the strong transverse target field (2.5 T and 5.0 T) and the varied field configurations of the septum magnets. The details of the optics calibration and the progress will be described in this talk.

  17. KSi2P3: A new layered phosphidopolysilicate (IV)

    NASA Astrophysics Data System (ADS)

    Feng, Kai; Kang, Lei; Yin, Wenlong; Hao, Wenyu; Lin, Zheshuai; Yao, Jiyong; Wu, Yicheng

    2013-09-01

    A new ternary phosphidopolysilicate (IV), KSi2P3, has been synthesized by high temperature solid state reaction. The compound crystallizes in a new structure type in the monoclinic space group C2/c with a=10.1327(5) Å, b=10.1382(5) Å, c=21.1181(10) Å, β=96.88(0)°, and Z=8. In the structure, all SiP4 tetrahedra are connected with each other by corner-sharing P atoms to form [P3]-∞2 layers, which are stacked along c direction and separated by K+ cations. The two-dimensional structure of KSi2P3 contrasts with those of the two known members in the ternary A/Si/P (A=alkali metal) system, namely Na5SiP3 (zero-dimensional) and K2SiP2 (one-dimensional), which contains less amount of Si. The band gap deduced from UV-vis-IR diffuse reflectance spectrum is 1.72 eV.

  18. Fragrance material review on 2-p-tolylethanol.

    PubMed

    Scognamiglio, J; Jones, L; Letizia, C S; Api, A M

    2012-09-01

    A toxicologic and dermatologic review of 2-p-tolylethanol when used as a fragrance ingredient is presented. 2-p-tolylethanol is a member of the fragrance structural group Aryl Alkyl Alcohols and is a primary alcohol. The AAAs are a structurally diverse class of fragrance ingredients that includes primary, secondary, and tertiary alkyl alcohols covalently bonded to an aryl (Ar) group, which may be either a substituted or unsubstituted benzene ring. The common structural element for the AAA fragrance ingredients is an alcohol group-C-(R1)(R2)OH and generically the AAA fragrances can be represented as an Ar-C-(R1)(R2)OH or Ar-Alkyl-C-(R1)(R2)OH group. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. A safety assessment of the entire Aryl Alkyl Alcohols will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all other branched chain saturated alcohols in fragrances.

  19. The RP-Mdm2-p53 Pathway and Tumorigenesis

    PubMed Central

    Miliani de Marval, Paula L.; Zhang, Yanping

    2011-01-01

    The dynamic processes of cell growth and division are under constant surveillance. As one of the primary “gatekeepers” of the cell, the p53 tumor suppressor plays a major role in sensing and responding to a variety of stressors to maintain cellular homeostasis. Recent studies have shown that inhibition of ribosomal biogenesis can activate p53 through ribosomal protein (RP)-mediated suppression of Mdm2 E3 ligase activity. Mutations in Mdm2 that disrupt RP binding have been detected in human cancers; however, the physiological significance of the RP-Mdm2 interaction is not completely understood. We generated mice carrying a single cysteine-to-phenylalanine substitution in the central zinc finger of Mdm2 (Mdm2C305F) that disrupts Mdm2’s binding to RPL11 and RPL5. Despite being developmentally normal and maintaining an intact p53 response to DNA damage, the Mdm2C305F mice demonstrate a diminished p53 response to perturbations in ribosomal biogenesis, providing the first in vivo evidence for an RP-Mdm2-p53 signaling pathway. Here we review some recent studies about RP-Mdm2-p53 signaling and speculate on the relevance of this pathway to human cancer. PMID:21406728

  20. Effective Majorana neutrino decay

    NASA Astrophysics Data System (ADS)

    Duarte, Lucía; Romero, Ismael; Peressutti, Javier; Sampayo, Oscar A.

    2016-08-01

    We study the decay of heavy sterile Majorana neutrinos according to the interactions obtained from an effective general theory. We describe the two- and three-body decays for a wide range of neutrino masses. The results obtained and presented in this work could be useful for the study of the production and detection of these particles in a variety of high energy physics experiments and astrophysical observations. We show in different figures the dominant branching ratios and the total decay width.

  1. Inclusive and exclusive measurements of B decays to χc 1 and χc 2 at Belle

    NASA Astrophysics Data System (ADS)

    Bhardwaj, V.; Miyabayashi, K.; Panzenböck, E.; Trabelsi, K.; Frey, A.; Abdesselam, A.; Adachi, I.; Aihara, H.; Al Said, S.; Arinstein, K.; Asner, D. M.; Atmacan, H.; Aulchenko, V.; Aushev, T.; Ayad, R.; Babu, V.; Badhrees, I.; Bahinipati, S.; Bakich, A. M.; Bala, A.; Bansal, V.; Barberio, E.; Bhuyan, B.; Biswal, J.; Bobrov, A.; Bondar, A.; Bozek, A.; Bračko, M.; Browder, T. E.; Červenkov, D.; Chekelian, V.; Chen, A.; Cheon, B. G.; Chilikin, K.; Chistov, R.; Cho, K.; Chobanova, V.; Choi, S.-K.; Choi, Y.; Cinabro, D.; Dalseno, J.; Danilov, M.; Doležal, Z.; Dutta, D.; Eidelman, S.; Farhat, H.; Fast, J. E.; Ferber, T.; Frost, O.; Fulsom, B. G.; Gaur, V.; Gabyshev, N.; Ganguly, S.; Garmash, A.; Gillard, R.; Glattauer, R.; Goh, Y. M.; Goldenzweig, P.; Golob, B.; Greenwald, D.; Haba, J.; Hamer, P.; Hayasaka, K.; Hayashii, H.; He, X. H.; Hou, W.-S.; Iijima, T.; Inami, K.; Ishikawa, A.; Itoh, R.; Iwasaki, Y.; Jaegle, I.; Joffe, D.; Joo, K. K.; Julius, T.; Kato, E.; Katrenko, P.; Kawasaki, T.; Kiesling, C.; Kim, D. Y.; Kim, J. B.; Kim, K. T.; Kim, M. J.; Kim, S. H.; Kim, Y. J.; Kinoshita, K.; Ko, B. R.; Kobayashi, N.; Kodyš, P.; Korpar, S.; Križan, P.; Krokovny, P.; Kuhr, T.; Kumar, R.; Kumita, T.; Kuzmin, A.; Kwon, Y.-J.; Lee, I. S.; Li, C.; Li, Y.; Li Gioi, L.; Libby, J.; Liventsev, D.; Loos, A.; Lukin, P.; Masuda, M.; Matvienko, D.; Miyata, H.; Mizuk, R.; Mohanty, G. B.; Mohanty, S.; Moll, A.; Moon, H. K.; Mussa, R.; Nakano, E.; Nakao, M.; Nanut, T.; Natkaniec, Z.; Nayak, M.; Nisar, N. K.; Nishida, S.; Ogawa, S.; Okuno, S.; Pakhlova, G.; Pal, B.; Park, C. W.; Park, H.; Pedlar, T. K.; Pestotnik, R.; Petrič, M.; Piilonen, L. E.; Pulvermacher, C.; Purohit, M. V.; Rauch, J.; Ribežl, E.; Ritter, M.; Rostomyan, A.; Sahoo, H.; Sakai, Y.; Sandilya, S.; Santelj, L.; Sanuki, T.; Sato, Y.; Savinov, V.; Schneider, O.; Schnell, G.; Schwanda, C.; Seino, Y.; Semmler, D.; Senyo, K.; Seon, O.; Sevior, M. E.; Shebalin, V.; Shen, C. P.; Shibata, T.-A.; Shiu, J.-G.; Shwartz, B.; Simon, F.; Singh, J. B.; Sohn, Y.-S.; Sokolov, A.; Solovieva, E.; Starič, M.; Stypula, J.; Sumihama, M.; Sumiyoshi, T.; Tamponi, U.; Tanida, K.; Teramoto, Y.; Uchida, M.; Uehara, S.; Uglov, T.; Unno, Y.; Uno, S.; Urquijo, P.; Usov, Y.; Van Hulse, C.; Vanhoefer, P.; Varner, G.; Vinokurova, A.; Vorobyev, V.; Wang, C. H.; Wang, M.-Z.; Wang, P.; Wang, X. L.; Watanabe, M.; Watanabe, Y.; Wehle, S.; Won, E.; Yamaoka, J.; Yashchenko, S.; Ye, H.; Yook, Y.; Yuan, C. Z.; Yusa, Y.; Zhang, Z. P.; Zhilich, V.; Zhulanov, V.; Zupanc, A.; Belle Collaboration

    2016-03-01

    We report inclusive and exclusive measurements for χc 1 and χc 2 production in B decays. We measure B (B →χc 1X )=(3.03 ±0.05 (stat )±0.24 (syst ))×10-3 and B (B →χc 2X )=(0.70 ±0.06 (stat )±0.10 (syst ))×10-3 . For the first time, χc 2 production in exclusive B decays in the modes B0→χc 2π-K+ and B+→χc 2π+π-K+ has been observed, along with first evidence for the B+→χc 2π+KS0 decay mode. For χc 1 production, we report the first observation in the B+→χc 1π+π-K+ , B0→χc 1π+π-KS0 and B0→χc 1π0π-K+ decay modes. Using these decay modes, we observe a difference in the production mechanism of χc 2 in comparison to χc 1 in B decays. In addition, we report searches for X (3872 ) and χc 1(2 P ) in the B+→(χc 1π+π-)K+ decay mode. The reported results use 772 ×106 B B ¯ events collected at the ϒ (4 S ) resonance with the Belle detector at the KEKB asymmetric-energy e+e- collider.

  2. Genomewide analysis of polysaccharides degrading enzymes in 11 white- and brown-rot Polyporales provides insight into mechanisms of wood decay.

    PubMed

    Hori, Chiaki; Gaskell, Jill; Igarashi, Kiyohiko; Samejima, Masahiro; Hibbett, David; Henrissat, Bernard; Cullen, Dan

    2013-01-01

    To degrade the polysaccharides, wood-decay fungi secrete a variety of glycoside hydrolases (GHs) and carbohydrate esterases (CEs) classified into various sequence-based families of carbohydrate-active enzymes (CAZys) and their appended carbohydrate-binding modules (CBM). Oxidative enzymes, such as cellobiose dehydrogenase (CDH) and lytic polysaccharide monooxygenase (LPMO, formerly GH61), also have been implicated in cellulose degradation. To examine polysaccharide-degrading potential between white- and brown-rot fungi, we performed genomewide analysis of CAZys and these oxidative enzymes in 11 Polyporales, including recently sequenced monokaryotic strains of Bjerkandera adusta, Ganoderma sp. and Phlebia brevispora. Furthermore, we conducted comparative secretome analysis of seven Polyporales grown on wood culture. As a result, it was found that genes encoding cellulases belonging to families GH6, GH7, GH9 and carbohydrate-binding module family CBM1 are lacking in genomes of brown-rot polyporales. In addition, the presence of CDH and the expansion of LPMO were observed only in white-rot genomes. Indeed, GH6, GH7, CDH and LPMO peptides were identified only in white-rot polypores. Genes encoding aldose 1-epimerase (ALE), previously detected with CDH and cellulases in the culture filtrates, also were identified in white-rot genomes, suggesting a physiological connection between ALE, CDH, cellulase and possibly LPMO. For hemicellulose degradation, genes and peptides corresponding to GH74 xyloglucanase, GH10 endo-xylanase, GH79 β-glucuronidase, CE1 acetyl xylan esterase and CE15 glucuronoyl methylesterase were significantly increased in white-rot genomes compared to brown-rot genomes. Overall, relative to brown-rot Polyporales, white-rot Polyporales maintain greater enzymatic diversity supporting lignocellulose attack.

  3. Vacuum decay in a soluble model

    SciTech Connect

    Ferraz de Camargo F, A.; Shellard, R.C.; Marques, G.C.

    1984-03-15

    We study a field-theoretical model where the decay rate of the false vacuum can be computed up to the first quantum corrections in both the high-temperature and zero-temperature limits. We find that the dependence of the decay rate on the height and width of the potential barrier does not follow the same simple area rule as in the quantum-mechanical case. Furthermore, its behavior is strongly model dependent.

  4. Tuning fork decay.

    PubMed

    Miller, G W

    1979-03-01

    Tuning fork tests are used routinely by many otologists. A different group of otologists find the tests inconsistent and unreliable. This controversy has probably developed because the audiometer has replaced the tuning fork in hearing measurement. As a result, the art of use of the tuning fork is poorly learned. This study examines decay, one of the physical parameters of tuning forks. Measurements of acoustic (sound wave) and vibration (stem movement) decay were made. Alteration in decay due to pressure changes on the fork stem were studied. Acoustic signals were generated in an anechoic chamber. Vibration measurements were obtained using an artificial mastoid. Analysis of the signals was accomplished by a system of amplifiers, filters, tape recorders, and a graphic recorder. Tuning fork sound decay is a property of the instrument which occurs every time the fork is struck. The decay is a constant in decibels per second. The acoustic mode and the vibration mode decay at similar rates for the same fork. The strike frequency (a higher frequency than the fundamental produced when the fork is struck) also has a constant decay rate in decibels per second, and it is reported here for the first time. Force of 800 gm. and less applied to the bottom of the stem in vibration measurement caused minimal decay constant changes. When the physical parameters of the tuning fork (including this information on damping) are fully studied, tuning fork testing should become more of a science and less of an art.

  5. Radioactive Decay - An Analog.

    ERIC Educational Resources Information Center

    McGeachy, Frank

    1988-01-01

    Presents an analog of radioactive decay that allows the student to grasp the concept of half life and the exponential nature of the decay process. The analog is devised to use small, colored, plastic poker chips or counters. Provides the typical data and a graph which supports the analog. (YP)

  6. Lyapunov decay in quantum irreversibility.

    PubMed

    García-Mata, Ignacio; Roncaglia, Augusto J; Wisniacki, Diego A

    2016-06-13

    The Loschmidt echo--also known as fidelity--is a very useful tool to study irreversibility in quantum mechanics due to perturbations or imperfections. Many different regimes, as a function of time and strength of the perturbation, have been identified. For chaotic systems, there is a range of perturbation strengths where the decay of the Loschmidt echo is perturbation independent, and given by the classical Lyapunov exponent. But observation of the Lyapunov decay depends strongly on the type of initial state upon which an average is carried out. This dependence can be removed by averaging the fidelity over the Haar measure, and the Lyapunov regime is recovered, as has been shown for quantum maps. In this work, we introduce an analogous quantity for systems with infinite dimensional Hilbert space, in particular the quantum stadium billiard, and we show clearly the universality of the Lyapunov regime. PMID:27140966

  7. Cortical regulation of cell size by a sizer cdr2p

    PubMed Central

    Pan, Kally Z; Saunders, Timothy E; Flor-Parra, Ignacio; Howard, Martin; Chang, Fred

    2014-01-01

    Cells can, in principle, control their size by growing to a specified size before commencing cell division. How any cell actually senses its own size remains poorly understood. The fission yeast Schizosaccharomyces pombe are rod-shaped cells that grow to ∼14 µm in length before entering mitosis. In this study, we provide evidence that these cells sense their surface area as part of this size control mechanism. We show that cells enter mitosis at a certain surface area, as opposed to a certain volume or length. A peripheral membrane protein kinase cdr2p has properties of a dose-dependent ‘sizer’ that controls mitotic entry. As cells grow, the local cdr2p concentration in nodes at the medial cortex accumulates as a measure of cell surface area. Our findings, which challenge a previously proposed pom1p gradient model, lead to a new model in which cells sense their size by using cdr2p to probe the surface area over the whole cell and relay this information to the medial cortex. DOI: http://dx.doi.org/10.7554/eLife.02040.001 PMID:24642412

  8. Bottomonium spectroscopy and radiative transitions involving the χb J(1 P ,2 P ) states at BaBar

    NASA Astrophysics Data System (ADS)

    Lees, J. P.; Poireau, V.; Tisserand, V.; Grauges, E.; Palano, A.; Eigen, G.; Stugu, B.; Brown, D. N.; Kerth, L. T.; Kolomensky, Yu. G.; Lee, M. J.; Lynch, G.; Koch, H.; Schroeder, T.; Hearty, C.; Mattison, T. S.; McKenna, J. A.; So, R. Y.; Khan, A.; Blinov, V. E.; Buzykaev, A. R.; Druzhinin, V. P.; Golubev, V. B.; Kravchenko, E. A.; Onuchin, A. P.; Serednyakov, S. I.; Skovpen, Yu. I.; Solodov, E. P.; Todyshev, K. Yu.; Lankford, A. J.; Mandelkern, M.; Dey, B.; Gary, J. W.; Long, O.; Campagnari, C.; Franco Sevilla, M.; Hong, T. M.; Kovalskyi, D.; Richman, J. D.; West, C. A.; Eisner, A. M.; Lockman, W. S.; Panduro Vazquez, W.; Schumm, B. A.; Seiden, A.; Chao, D. S.; Cheng, C. H.; Echenard, B.; Flood, K. T.; Hitlin, D. G.; Miyashita, T. S.; Ongmongkolkul, P.; Porter, F. C.; Roehrken, M.; Andreassen, R.; Huard, Z.; Meadows, B. T.; Pushpawela, B. G.; Sokoloff, M. D.; Sun, L.; Bloom, P. C.; Ford, W. T.; Gaz, A.; Smith, J. G.; Wagner, S. R.; Ayad, R.; Toki, W. H.; Spaan, B.; Bernard, D.; Verderi, M.; Playfer, S.; Bettoni, D.; Bozzi, C.; Calabrese, R.; Cibinetto, G.; Fioravanti, E.; Garzia, I.; Luppi, E.; Piemontese, L.; Santoro, V.; Calcaterra, A.; de Sangro, R.; Finocchiaro, G.; Martellotti, S.; Patteri, P.; Peruzzi, I. M.; Piccolo, M.; Rama, M.; Zallo, A.; Contri, R.; Lo Vetere, M.; Monge, M. R.; Passaggio, S.; Patrignani, C.; Robutti, E.; Bhuyan, B.; Prasad, V.; Adametz, A.; Uwer, U.; Lacker, H. M.; Dauncey, P. D.; Mallik, U.; Chen, C.; Cochran, J.; Prell, S.; Ahmed, H.; Gritsan, A. V.; Arnaud, N.; Davier, M.; Derkach, D.; Grosdidier, G.; Le Diberder, F.; Lutz, A. M.; Malaescu, B.; Roudeau, P.; Stocchi, A.; Wormser, G.; Lange, D. J.; Wright, D. M.; Coleman, J. P.; Fry, J. R.; Gabathuler, E.; Hutchcroft, D. E.; Payne, D. J.; Touramanis, C.; Bevan, A. J.; Di Lodovico, F.; Sacco, R.; Cowan, G.; Bougher, J.; Brown, D. N.; Davis, C. L.; Denig, A. G.; Fritsch, M.; Gradl, W.; Griessinger, K.; Hafner, A.; Schubert, K. R.; Barlow, R. J.; Lafferty, G. D.; Cenci, R.; Hamilton, B.; Jawahery, A.; Roberts, D. A.; Cowan, R.; Sciolla, G.; Cheaib, R.; Patel, P. M.; Robertson, S. H.; Neri, N.; Palombo, F.; Cremaldi, L.; Godang, R.; Sonnek, P.; Summers, D. J.; Simard, M.; Taras, P.; De Nardo, G.; Onorato, G.; Sciacca, C.; Martinelli, M.; Raven, G.; Jessop, C. P.; LoSecco, J. M.; Honscheid, K.; Kass, R.; Feltresi, E.; Margoni, M.; Morandin, M.; Posocco, M.; Rotondo, M.; Simi, G.; Simonetto, F.; Stroili, R.; Akar, S.; Ben-Haim, E.; Bomben, M.; Bonneaud, G. R.; Briand, H.; Calderini, G.; Chauveau, J.; Leruste, Ph.; Marchiori, G.; Ocariz, J.; Biasini, M.; Manoni, E.; Pacetti, S.; Rossi, A.; Angelini, C.; Batignani, G.; Bettarini, S.; Carpinelli, M.; Casarosa, G.; Cervelli, A.; Chrzaszcz, M.; Forti, F.; Giorgi, M. A.; Lusiani, A.; Oberhof, B.; Paoloni, E.; Perez, A.; Rizzo, G.; Walsh, J. J.; Lopes Pegna, D.; Olsen, J.; Smith, A. J. S.; Faccini, R.; Ferrarotto, F.; Ferroni, F.; Gaspero, M.; Li Gioi, L.; Pilloni, A.; Piredda, G.; Bünger, C.; Dittrich, S.; Grünberg, O.; Hess, M.; Leddig, T.; Voß, C.; Waldi, R.; Adye, T.; Olaiya, E. O.; Wilson, F. F.; Emery, S.; Vasseur, G.; Anulli, F.; Aston, D.; Bard, D. J.; Cartaro, C.; Convery, M. R.; Dorfan, J.; Dubois-Felsmann, G. P.; Dunwoodie, W.; Ebert, M.; Field, R. C.; Fulsom, B. G.; Graham, M. T.; Hast, C.; Innes, W. R.; Kim, P.; Leith, D. W. G. S.; Lewis, P.; Lindemann, D.; Luitz, S.; Luth, V.; Lynch, H. L.; MacFarlane, D. B.; Muller, D. R.; Neal, H.; Perl, M.; Pulliam, T.; Ratcliff, B. N.; Roodman, A.; Salnikov, A. A.; Schindler, R. H.; Snyder, A.; Su, D.; Sullivan, M. K.; Va'vra, J.; Wisniewski, W. J.; Wulsin, H. W.; Purohit, M. V.; White, R. M.; Wilson, J. R.; Randle-Conde, A.; Sekula, S. J.; Bellis, M.; Burchat, P. R.; Puccio, E. M. T.; Alam, M. S.; Ernst, J. A.; Gorodeisky, R.; Guttman, N.; Peimer, D. R.; Soffer, A.; Spanier, S. M.; Ritchie, J. L.; Ruland, A. M.; Schwitters, R. F.; Wray, B. C.; Izen, J. M.; Lou, X. C.; Bianchi, F.; De Mori, F.; Filippi, A.; Gamba, D.; Lanceri, L.; Vitale, L.; Martinez-Vidal, F.; Oyanguren, A.; Villanueva-Perez, P.; Albert, J.; Banerjee, Sw.; Beaulieu, A.; Bernlochner, F. U.; Choi, H. H. F.; King, G. J.; Kowalewski, R.; Lewczuk, M. J.; Lueck, T.; Nugent, I. M.; Roney, J. M.; Sobie, R. J.; Tasneem, N.; Gershon, T. J.; Harrison, P. F.; Latham, T. E.; Band, H. R.; Dasu, S.; Pan, Y.; Prepost, R.; Wu, S. L.; BaBar Collaboration

    2014-12-01

    We use (121 ±1 ) million Υ (3 S ) and (98 ±1 ) million Υ (2 S ) mesons recorded by the BABAR detector at the PEP-II e+e- collider at SLAC to perform a study of radiative transitions involving the χb J(1 P ,2 P ) states in exclusive decays with μ+μ- γ γ final states. We reconstruct twelve channels in four cascades using two complementary methods. In the first we identify both signal photon candidates in the electromagnetic calorimeter (EMC), employ a calorimeter timing-based technique to reduce backgrounds, and determine branching-ratio products and fine mass splittings. These results include the best observational significance yet for the χb 0(2 P )→γ Υ (2 S ) and χb 0(1 P )→γ Υ (1 S ) transitions. In the second method, we identify one photon candidate in the EMC and one which has converted into an e+e- pair due to interaction with detector material, and we measure absolute product branching fractions. This method is particularly useful for measuring Υ (3 S )→γ χb 1 ,2(1 P ) decays. Additionally, we provide the most up-to-date derived branching fractions, matrix elements and mass splittings for χb transitions in the bottomonium system. Using a new technique, we also measure the two lowest-order spin-dependent coefficients in the nonrelativistic QCD Hamiltonian.

  9. CCQE, 2p2h excitations and ν—energy reconstruction

    SciTech Connect

    Nieves, J.; Simo, I. Ruiz; Sánchez, F.; Vacas, M. J. Vicente

    2015-05-15

    We analyze the MiniBooNE muon neutrino CCQE-like dσ/dT{sub μ} d cos θ{sub μ} data using a theoretical model that, among other nuclear effects, includes RPA correlations and 2p2h (multinucleon) mechanisms. These corrections turn out to be essential for the description of the data. We find that MiniBooNE CCQE-like data are fully compatible with former determinations of the nucleon axial mass M{sub A} ∼ 1.05 GeV. This is in sharp contrast with several previous analysis where anomalously large values of M{sub A} ∼ 1.4 GeV have been suggested. We also show that because of the the multinucleon mechanism effects, the algorithm used to reconstruct the neutrino energy is not adequate when dealing with quasielastic-like events. Finally, we analyze the MiniBooNE unfolded cross section, and show that it exhibits an excess (deficit) of low (high) energy neutrinos, which is an artifact of the unfolding process that ignores 2p2h mechanisms.

  10. Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction

    PubMed Central

    Thayer, Kelly M.; Beyer, George A.

    2016-01-01

    The ubiquitin ligase MDM2, a principle regulator of the tumor suppressor p53, plays an integral role in regulating cellular levels of p53 and thus a prominent role in current cancer research. Computational analysis used MUMBO to rotamerize the MDM2-p53 crystal structure 1YCR to obtain an exhaustive search of point mutations, resulting in the calculation of the ΔΔG comprehensive energy landscape for the p53-bound regulator. The results herein have revealed a set of residues R65-E69 on MDM2 proximal to the p53 hydrophobic binding pocket that exhibited an energetic profile deviating significantly from similar residues elsewhere in the protein. In light of the continued search for novel competitive inhibitors for MDM2, we discuss possible implications of our findings on the drug discovery field. PMID:26992014

  11. Energetic Landscape of MDM2-p53 Interactions by Computational Mutagenesis of the MDM2-p53 Interaction.

    PubMed

    Thayer, Kelly M; Beyer, George A

    2016-01-01

    The ubiquitin ligase MDM2, a principle regulator of the tumor suppressor p53, plays an integral role in regulating cellular levels of p53 and thus a prominent role in current cancer research. Computational analysis used MUMBO to rotamerize the MDM2-p53 crystal structure 1YCR to obtain an exhaustive search of point mutations, resulting in the calculation of the ΔΔG comprehensive energy landscape for the p53-bound regulator. The results herein have revealed a set of residues R65-E69 on MDM2 proximal to the p53 hydrophobic binding pocket that exhibited an energetic profile deviating significantly from similar residues elsewhere in the protein. In light of the continued search for novel competitive inhibitors for MDM2, we discuss possible implications of our findings on the drug discovery field. PMID:26992014

  12. P2P proteomics -- data sharing for enhanced protein identification

    PubMed Central

    2012-01-01

    Background In order to tackle the important and challenging problem in proteomics of identifying known and new protein sequences using high-throughput methods, we propose a data-sharing platform that uses fully distributed P2P technologies to share specifications of peer-interaction protocols and service components. By using such a platform, information to be searched is no longer centralised in a few repositories but gathered from experiments in peer proteomics laboratories, which can subsequently be searched by fellow researchers. Methods The system distributively runs a data-sharing protocol specified in the Lightweight Communication Calculus underlying the system through which researchers interact via message passing. For this, researchers interact with the system through particular components that link to database querying systems based on BLAST and/or OMSSA and GUI-based visualisation environments. We have tested the proposed platform with data drawn from preexisting MS/MS data reservoirs from the 2006 ABRF (Association of Biomolecular Resource Facilities) test sample, which was extensively tested during the ABRF Proteomics Standards Research Group 2006 worldwide survey. In particular we have taken the data available from a subset of proteomics laboratories of Spain's National Institute for Proteomics, ProteoRed, a network for the coordination, integration and development of the Spanish proteomics facilities. Results and Discussion We performed queries against nine databases including seven ProteoRed proteomics laboratories, the NCBI Swiss-Prot database and the local database of the CSIC/UAB Proteomics Laboratory. A detailed analysis of the results indicated the presence of a protein that was supported by other NCBI matches and highly scored matches in several proteomics labs. The analysis clearly indicated that the protein was a relatively high concentrated contaminant that could be present in the ABRF sample. This fact is evident from the information that

  13. Interaction among Btn1p, Btn2p, and Ist2p reveals potential interplay among the vacuole, amino acid levels, and ion homeostasis in the yeast Saccharomyces cerevisiae.

    PubMed

    Kim, Yoojin; Chattopadhyay, Subrata; Locke, Sarahjane; Pearce, David A

    2005-02-01

    Btn2p, a novel cytosolic coiled-coil protein in Saccharomyces cerevisiae, was previously shown to interact with and to be necessary for the correct localization of Rhb1p, a regulator of arginine uptake, and Yif1p, a Golgi protein. We now report the biochemical and physical interactions of Btn2p with Ist2p, a plasma membrane protein that is thought to have a function in salt tolerance. A deletion in Btn2p (btn2Delta strains) results in a failure to correctly localize Ist2p, and strains lacking Btn2p and Ist2p (btn2Delta ist2Delta strains) are unable to grow in the presence of 0.5 or 1.0 M NaCl. Btn2p was originally identified as being up-regulated in a btn1Delta strain, which lacks the vacuolar-lysosomal membrane protein, Btn1p, and serves as a model for Batten disease. This up-regulation of Btn2p was shown to contribute to the maintenance of a stable vacuolar pH in the btn1Delta strain. Btn1p was subsequently shown to be required for the optimal transport of arginine into the vacuole. Interestingly, btn1Delta ist2Delta strains are also unable to grow in the presence of 0.5 or 1.0 M NaCl, and ist2Delta suppresses the vacuolar arginine transport defect in btn1Delta strains. Although further investigation is required, we speculate that altered vacuolar arginine transport in btn1Delta strains represents a mechanism for maintaining or balancing cellular ion homeostasis. Btn2p interacts with at least three proteins that are seemingly involved in different biological functions in different subcellular locations. Due to these multiple interactions, we conclude that Btn2p may play a regulatory role across the cell in response to alterations in the intracellular environment that may be caused by changes in amino acid levels or pH, a disruption in protein trafficking, or imbalances in ion homeostasis resulting from either genetic or environmental manipulation.

  14. Multicast Services over Structured P2P Networks

    NASA Astrophysics Data System (ADS)

    Manzanares-Lopez, Pilar; Malgosa-Sanahuja, Josemaria; Muñoz-Gea, Juan Pedro; Sanchez-Aarnoutse, Juan Carlos

    IP multicast functionality was defined as an efficient method to transmit datagrams to a group of receivers. However, although a lot of research work has been done in this technology, IP multicast has not spread out over the Internet as much as expected, reducing its use for local environments (i.e., LANs). The peer-to-peer networks paradigm can be used to overcome the IP multicast limitations. In this new scenario (called Application Layer Multicast or ALM), the multicast functionality is changed from network to application layer. Although ALM solution can be classified into unstructured and structured solutions, the last ones are the best option to offer multicast services due to the effectiveness in the discovery nodes, their mathematical definition and the totally decentralized management. In this chapter we are going to offer a tutorial of the main structured ALM solutions, but introducing two novelties with respect to related surveys in the past: first, the systematic description of most representative structured ALM solution in OverSim (one of the most popular p2p simulation frameworks). Second, some simulation comparatives between flooding-based and tree-based structured ALM solution are also presented.

  15. Migration of Dust Particles from Comet 2P Encke

    NASA Technical Reports Server (NTRS)

    Ipatov, S. I.

    2003-01-01

    We investigated the migration of dust particles under the gravitational influence of all planets (except for Pluto), radiation pressure, Poynting-Robertson drag and solar wind drag for Beta equal to 0.002, 0.004, 0.01, 0.05, 0.1, 0.2, and 0.4. For silicate particles such values of Beta correspond to diameters equal to about 200, 100, 40, 9, 4, 2, and 1 microns, respectively. We used the Bulirsh-Stoer method of integration, and the relative error per integration step was taken to be less than lo-'. Initial orbits of the particles were close to the orbit of Comet 2P Encke. We considered initial particles near perihelion (runs denoted as Delta tsub o, = 0), near aphelion (Delta tsub o, = 0.5), and also studied their initial positions when the comet moved for Pa/4 after perihelion passage (such runs are denoted as Delta tsub o, =i 0.25), where Pa is the period of the comet. Variations in time T when perihelion was passed was varied with a step 0.1 day for series 'S' and with a step 1 day for series 'L'. For each Beta we considered N = 101 particles for "S" runs and 150 particles for "L" runs.

  16. Decay of Turbulence at High Reynolds Numbers

    NASA Astrophysics Data System (ADS)

    Sinhuber, Michael; Bodenschatz, Eberhard; Bewley, Gregory P.

    2015-01-01

    Turbulent motions in a fluid decay at a certain rate once stirring has stopped. The role of the most basic parameter in fluid mechanics, the Reynolds number, in setting the decay rate is not generally known. This Letter concerns the high-Reynolds-number limit of the process. In a classical grid-turbulence wind-tunnel experiment that both reaches higher Reynolds numbers than ever before and covers a wide range of them (1 04decay rate with the unprecedented precision of about 2%. Here U is the mean speed of the flow, M is the forcing scale, and ν is the kinematic viscosity of the fluid. We observe that the decay rate is Reynolds-number independent, which contradicts some models and supports others.

  17. Axions from wall decay

    SciTech Connect

    Chang, S; Hagmann, C; Sikivie, P

    2001-01-08

    The authors discuss the decay of axion walls bounded by strings and present numerical simulations of the decay process. In these simulations, the decay happens immediately, in a time scale of order the light travel time, and the average energy of the radiated axions is {approx_equal} 7m{sub a} for v{sub a}/m{sub a} {approx_equal} 500. is found to increase approximately linearly with ln(v{sub a}/m{sub a}). Extrapolation of this behavior yields {approx_equal} 60 m{sub a} in axion models of interest.

  18. Modulated curvaton decay

    SciTech Connect

    Assadullahi, Hooshyar; Wands, David; Firouzjahi, Hassan; Namjoo, Mohammad Hossein E-mail: firouz@mail.ipm.ir E-mail: david.wands@port.ac.uk

    2013-03-01

    We study primordial density perturbations generated by the late decay of a curvaton field whose decay rate may be modulated by the local value of another isocurvature field, analogous to models of modulated reheating at the end of inflation. We calculate the primordial density perturbation and its local-type non-Gaussianity using the sudden-decay approximation for the curvaton field, recovering standard curvaton and modulated reheating results as limiting cases. We verify the Suyama-Yamaguchi inequality between bispectrum and trispectrum parameters for the primordial density field generated by multiple field fluctuations, and find conditions for the bound to be saturated.

  19. The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p

    PubMed Central

    Stalder, Danièle; Novick, Peter J.

    2016-01-01

    Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P). Sec2p also binds to the Sec4p effector Sec15p, yet Ypt32p and Sec15p compete against each other for binding to Sec2p. We report here that the redundant casein kinases Yck1p and Yck2p phosphorylate sites within the Ypt32p/Sec15p binding region and in doing so promote binding to Sec15p and inhibit binding to Ypt32p. We show that Yck2p binds to the autoinhibitory domain of Sec2p, adjacent to the PI(4)P binding site, and that addition of PI(4)P inhibits Sec2p phosphorylation by Yck2p. Loss of Yck1p and Yck2p function leads to accumulation of an intracellular pool of the secreted glucanase Bgl2p, as well as to accumulation of Golgi-related structures in the cytoplasm. We propose that Sec2p is phosphorylated after it has been recruited to secretory vesicles and the level of PI(4)P has been reduced. This promotes Sec2p function by stimulating its interaction with Sec15p. Finally, Sec2p is dephosphorylated very late in the exocytic reaction to facilitate recycling. PMID:26700316

  20. Observation of two-proton radioactivity of 19Mg by tracking the decay products.

    PubMed

    Mukha, I; Sümmerer, K; Acosta, L; Alvarez, M A G; Casarejos, E; Chatillon, A; Cortina-Gil, D; Espino, J; Fomichev, A; García-Ramos, J E; Geissel, H; Gómez-Camacho, J; Grigorenko, L; Hoffmann, J; Kiselev, O; Korsheninnikov, A; Kurz, N; Litvinov, Yu; Martel, I; Nociforo, C; Ott, W; Pfutzner, M; Rodríguez-Tajes, C; Roeckl, E; Stanoiu, M; Weick, H; Woods, P J

    2007-11-01

    We have observed the two-proton radioactivity of the previously unknown (19)Mg ground state by tracking the decay products in-flight. For the first time, the trajectories of the 2p-decay products, (17)Ne+p+p, have been measured by using tracking microstrip detectors which allowed us to reconstruct the 2p-decay vertices and fragment correlations. The half-life of (19)Mg deduced from the measured vertex distribution is 4.0(15) ps in the system of (19)Mg. The Q value of the 2p decay of the (19)Mg ground state inferred from the measured p-p-(17)Ne correlations is 0.75(5) MeV.

  1. RARE KAON DECAYS.

    SciTech Connect

    LITTENBERG, L.

    2005-07-19

    Lepton flavor violation (LFV) experiments have probed sensitivities corresponding to mass scales of well over 100 TeV, making life difficult for models predicting accessible LFV in kaon decay and discouraging new dedicated experiments of this type.

  2. Radiative B Decays

    SciTech Connect

    Bard, D.; /Imperial Coll., London

    2011-11-23

    I discuss recent results in radiative B decays from the Belle and BaBar collaborations. I report new measurements of the decay rate and CP asymmetries in b {yields} s{gamma} and b {yields} d{gamma} decays, and measurements of the photon spectrum in b {yields} s{gamma}. Radiative penguin decays are flavour changing neutral currents which do not occur at tree level in the standard model (SM), but must proceed via one loop or higher order diagrams. These transitions are therefore suppressed in the SM, but offer access to poorlyknown SM parameters and are also a sensitive probe of new physics. In the SM, the rate is dominated by the top quark contribution to the loop, but non-SM particles could also contribute with a size comparable to leading SM contributions. The new physics effects are potentially large which makes them theoretically very interesting, but due to their small branching fractions they are typically experimentally challenging.

  3. Charmless B Decays

    SciTech Connect

    Gradl, Wolfgang; /Edinburgh U.

    2007-03-06

    Rare charmless hadronic B decays are a good testing ground for the standard model. The dominant amplitudes contributing to this class of B decays are CKM suppressed tree diagrams and b {yields} s or b {yields} d loop diagrams (''penguins''). These decays can be used to study interfering standard model (SM) amplitudes and CP violation. They are sensitive to the presence of new particles in the loops, and they provide valuable information to constrain theoretical models of B decays. The B factories BABAR at SLAC and Belle at KEK produce B mesons in the reaction e{sup +}e{sup -} {yields} {Upsilon}(4S) {yields} B{bar B}. So far they have collected integrated luminosities of about 406 fb{sup -1} and 600 fb{sup -1}, respectively. The results presented here are based on subsets of about 200-500 fb{sup -1} and are preliminary unless a journal reference is given.

  4. One-pot synthesis of hierarchical Ni2P/MoS2 hybrid electrocatalysts with enhanced activity for hydrogen evolution reaction

    NASA Astrophysics Data System (ADS)

    Liu, Yan-Ru; Hu, Wen-Hui; Li, Xiao; Dong, Bin; Shang, Xiao; Han, Guan-Qun; Chai, Yong-Ming; Liu, Yun-Qi; Liu, Chen-Guang

    2016-10-01

    A simple one-pot synthesis method has been used to fabricate novel Ni2P/MoS2 hybrid electrocatalysts for hydrogen evolution reaction (HER). Owing to the weak conductivity and layered structure of MoS2, Ni2P nanoparticles with excellent conductivity and activity have been doped into MoS2 for improving the electrocatalytic performances for HER. The structure and morphology of the as-prepared Ni2P/MoS2 hybrid nanostructures are characterized. XRD and XPS show the elemental composition and valence of Ni2P/MoS2. SEM and TEM confirm that the close interaction of the hybrid materials and good dispersion of Ni2P nanoparticles. The as-synthesized Ni2P/MoS2 hybrid electrocatalysts exhibit excellent activity with onset overpotential of 75 mV and Tafle slope of 76 mV dec-1, which are much better than that of pure MoS2. The enhanced stability of the as-prepared Ni2P/MoS2 for HER has also been observed. The improved performances for HER may be ascribed to the better conductivity and dispersion of MoS2 nanosheets in Ni2P/MoS2 hybrid electrocatalysts. The small size and good dispersion of Ni2P nanoparticles also contributed to the enhancement of HER activity. Compared with mechanically mixed MoS2 and Ni2P (Ni2P-MoS2), Ni2P/MoS2 hybrid materials demonstrate better electrochemical performances for HER, implying the existence of synergistic effect between Ni2P and MoS2 on HER activity.

  5. Open Flavor Strong Decays

    NASA Astrophysics Data System (ADS)

    García-Tecocoatzi, H.; Bijker, R.; Ferretti, J.; Galatà, G.; Santopinto, E.

    2016-10-01

    In this contribution, we discuss the results of a QM calculation of the open-flavor strong decays of **** light nucleon resonances. These are the results of a recent calculation, where we used a modified ^3P_0 model for the amplitudes and the U(7) algebraic model and the hypercentral quark model to predict the baryon spectrum. The decay amplitudes are compared with the existing experimental data.

  6. Particle statistics affects quantum decay and Fano interference.

    PubMed

    Crespi, Andrea; Sansoni, Linda; Della Valle, Giuseppe; Ciamei, Alessio; Ramponi, Roberta; Sciarrino, Fabio; Mataloni, Paolo; Longhi, Stefano; Osellame, Roberto

    2015-03-01

    Quantum mechanical decay, Fano interference, and bound states with energy in the continuum are ubiquitous phenomena in different areas of physics. Here we experimentally demonstrate that particle statistics strongly affects quantum mechanical decay in a multiparticle system. By considering propagation of two-photon states in engineered photonic lattices, we simulate quantum decay of two noninteracting particles in a multilevel Fano-Anderson model. Remarkably, when the system sustains a bound state in the continuum, fractional decay is observed for bosonic particles, but not for fermionic ones. Complete decay in the fermionic case arises because of the Pauli exclusion principle, which forbids the bound state to be occupied by the two fermions. Our experiment indicates that particle statistics can tune many-body quantum decay from fractional to complete.

  7. Bremsstrahlung in {alpha} Decay Reexamined

    SciTech Connect

    Boie, H.; Scheit, H.; Jentschura, U. D.; Koeck, F.; Lauer, M.; Schwalm, D.; Milstein, A. I.; Terekhov, I. S.

    2007-07-13

    A high-statistics measurement of bremsstrahlung emitted in the {alpha} decay of {sup 210}Po has been performed, which allows us to follow the photon spectra up to energies of {approx}500 keV. The measured differential emission probability is in good agreement with our theoretical results obtained within the quasiclassical approximation as well as with the exact quantum mechanical calculation. It is shown that, due to the small effective electric dipole charge of the radiating system, a significant interference between the electric dipole and quadrupole contributions occurs, which is altering substantially the angular correlation between the {alpha} particle and the emitted photon.

  8. Bremsstrahlung in alpha decay reexamined.

    PubMed

    Boie, H; Scheit, H; Jentschura, U D; Köck, F; Lauer, M; Milstein, A I; Terekhov, I S; Schwalm, D

    2007-07-13

    A high-statistics measurement of bremsstrahlung emitted in the alpha decay of (210)Po has been performed, which allows us to follow the photon spectra up to energies of approximately 500 keV. The measured differential emission probability is in good agreement with our theoretical results obtained within the quasiclassical approximation as well as with the exact quantum mechanical calculation. It is shown that, due to the small effective electric dipole charge of the radiating system, a significant interference between the electric dipole and quadrupole contributions occurs, which is altering substantially the angular correlation between the alpha particle and the emitted photon.

  9. Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast

    SciTech Connect

    Shimada, Midori; Yamamoto, Ayumu; Murakami-Tonami, Yuko; Nakanishi, Makoto; Yoshida, Takashi; Aiba, Hirofumi; Murakami, Hiroshi

    2009-10-23

    The spindle checkpoint is a surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis. Here we show that fission yeast casein kinase II (CK2) is required for this checkpoint function. In the CK2 mutants mitosis occurs in the presence of a spindle defect, and the spindle checkpoint protein Mad2p fails to localize to unattached kinetochores. The CK2 mutants are sensitive to the microtubule depolymerising drug thiabendazole, which is counteracted by ectopic expression of mad2{sup +}. The level of Mad2p is low in the CK2 mutants. These results suggest that CK2 has a role in the spindle checkpoint by regulating Mad2p.

  10. Beta-decay rates

    NASA Astrophysics Data System (ADS)

    Borzov, I. N.

    2006-10-01

    Major astrophysical applications involve a huge number of exotic nuclei. Their beta-decay properties play a crucial role in stellar explosive events. An important effort has been developed in last decades to measure the masses and β-decay properties of very neutron-rich nuclei at radioactive nuclear beam facilities. However, most of them cannot be synthesized in terrestrial laboratories and only theoretical predictions can fill the gap. We will concentrate mainly on the β-decay rates needed for stellar r-process modeling and for performing the RNB experiments. An overview of the microscopic approaches to the β-decay strength function is given. The continuum QRPA approach based on the self-consistent ground state description in the framework of the density functional theory is outlined. For the first time, a systematic study of the total β-decay half-lives and delayed neutron emission probabilities takes into account the Gamow Teller and first-forbidden transitions. Due to the shell configuration effects, the first-forbidden decays have a strong impact on the β-decay characteristics of the r-process relevant nuclei at Z≈28, N>50; Z⩾50, N>82 and Z=60 70, N≈126. Suppression of the delayed neutron emission probability is found in nuclei with the neutron excess bigger than one major shell. The effect originates from the high-energy first-forbidden transitions to the states outside the (Q-B)-window in the daughter nuclei. The performance of existing global models for the nuclides near the r-process paths is critically analyzed and confronted with the recent RIB experiments in the regions of 78Ni, 132Sn and “east” of 208Pb.

  11. Complete correlation studies of two-proton decays: 6Be and 45Fe

    SciTech Connect

    Grigorenko, L.; Wiser, T. D.; Miernik, K.; Charity, R. J.; Pfutzner, M.; Banu, A.; Bingham, C. R.; Cwiok, Mikolaj; Darby, Iain; Dominik, W.; Elson, J. M.; Ginter, T. N.; Grzywacz, R.; Janas, Z.; Karny, M.; Korgul, A.; Liddick, Sean; Mercurio, K.; Rajabali, Mustafa; Rykaczewski, Krzysztof Piotr; Shane, R.; Sobotka, L. G.; Stolz, A.; Trache, L.; Tribble, R. E.; Wuosmaa, A. H.; Zhukov, M. V.

    2009-06-01

    The complete three-body correlation pictures are experimentally reconstructed for the two-proton decays of the 6Be and 45Fe ground states. We are able to see qualitative similarities and differences between these decays. They demonstrate very good agreement with the predictions of a theoretical three-body cluster model. Validity of the theoretical methods for treatment of the three-body Coulombic decays of this class is thus established by the broad range of lifetimes and nuclear masses spanned by these cases. Implementations for decay dynamics and nuclear structure of 2p emitters are discussed.

  12. Clg2p interacts with Clf and ClUrase to regulate appressorium formation, pathogenicity and conidial morphology in Curvularia lunata

    PubMed Central

    Liu, Tong; Wang, Yuying; Ma, Bingchen; Hou, Jumei; Jin, Yazhong; Zhang, Youli; Ke, Xiwang; Tai, Lianmei; Zuo, Yuhu; Dey, Kishore

    2016-01-01

    Ras is a small GTPase that regulates numerous processes in the cellular development and morphogenesis of many organisms. In this study, we identified and functionally characterized the Clg2p gene of Curvularia lunata, which is homologous with the Ras protein. The Clg2p deletion mutant (ΔClg2p) had altered appressorium formation and conidial morphology and produced fewer, smaller lesions compared with the wild-type strain. When a dominant Clg2p allele was introduced into the mutant, all of these defective phenotypes were completely restored. To further understand the regulation of Clg2p in appressorium formation and conidial morphology, and its role in pathogenicity, seven Clg2p-interacting proteins were screened using a yeast two-hybrid assay. Two of these proteins, Clf, a homologue of Mst11, which corresponds to MAP kinase kinase kinase in Magnaporthe oryzae, and urate oxidase (designated ClUrase) were functionally characterized. Clg2p specifically interacted with Clf through its RA domain to regulate appressorium formation and pathogenicity, whereas the Clg2p-ClUrase interaction regulated conidial morphology without affecting fungal pathogenicity. This report is the first to elucidate the regulatory mechanism of the key Ras protein Clg2p in C. lunata. PMID:27041392

  13. Clg2p interacts with Clf and ClUrase to regulate appressorium formation, pathogenicity and conidial morphology in Curvularia lunata.

    PubMed

    Liu, Tong; Wang, Yuying; Ma, Bingchen; Hou, Jumei; Jin, Yazhong; Zhang, Youli; Ke, Xiwang; Tai, Lianmei; Zuo, Yuhu; Dey, Kishore

    2016-01-01

    Ras is a small GTPase that regulates numerous processes in the cellular development and morphogenesis of many organisms. In this study, we identified and functionally characterized the Clg2p gene of Curvularia lunata, which is homologous with the Ras protein. The Clg2p deletion mutant (ΔClg2p) had altered appressorium formation and conidial morphology and produced fewer, smaller lesions compared with the wild-type strain. When a dominant Clg2p allele was introduced into the mutant, all of these defective phenotypes were completely restored. To further understand the regulation of Clg2p in appressorium formation and conidial morphology, and its role in pathogenicity, seven Clg2p-interacting proteins were screened using a yeast two-hybrid assay. Two of these proteins, Clf, a homologue of Mst11, which corresponds to MAP kinase kinase kinase in Magnaporthe oryzae, and urate oxidase (designated ClUrase) were functionally characterized. Clg2p specifically interacted with Clf through its RA domain to regulate appressorium formation and pathogenicity, whereas the Clg2p-ClUrase interaction regulated conidial morphology without affecting fungal pathogenicity. This report is the first to elucidate the regulatory mechanism of the key Ras protein Clg2p in C. lunata. PMID:27041392

  14. HALF-LIVES OF LONG-LIVED ALPHA DECAY, BETA DECAY, ELECTRON CAPTURE DECAY, BETA BETA-DECAY, PROTON DECAY AND SPONTANEOUS FISSION DECAY NUCLIDES.

    SciTech Connect

    HOLDEN, H.E.

    2003-08-08

    In his review of radionuclides for dating purposes, Roth noted that there were a large number of nuclides, normally considered ''stable'' but which are radioactive with a very long half-life. Roth suggested that I review the data on the half-life values of these long-lived nuclides for the 2001 Atomic Weights Commission meeting in Brisbane. I provided a report, BNL-NCS-68377, to fulfill Roth's request. Peiser has now made a similar suggestion that I review these data for our next Commission meeting in Ottawa for their possible inclusion in our Tables. These half-life values for long-lived nuclides include those due to various decay modes, {alpha}-decay, {beta}-decay, electron capture decay, {beta}{beta}-decay, proton decay and spontaneous fission decay. This data review (post Brisbane) provides an update to the recommendation of the 2001 review.

  15. Does mass accretion lead to field decay in neutron stars?

    NASA Technical Reports Server (NTRS)

    Shibazaki, N.; Murakami, T.; Shaham, J.; Nomoto, K.

    1989-01-01

    Adopting the hypothesis of accretion-induced magnetic field decay in neutron stars, the consequent evolution of a neutron star's spin and magnetic field are calculated. The results are consistent with observations of binary and millisecond radio pulsars. Thermomagnetic effects could provide a possible physical mechanism for such accretion-induced field decay.

  16. Cooperation enhanced by indirect reciprocity in spatial prisoner's dilemma games for social P2P systems

    NASA Astrophysics Data System (ADS)

    Tian, Lin-Lin; Li, Ming-Chu; Wang, Zhen

    2016-11-01

    With the growing interest in social Peer-to-Peer (P2P) applications, relationships of individuals are further exploited to improve the performances of reputation systems. It is an on-going challenge to investigate how spatial reciprocity aids indirect reciprocity in sustaining cooperation in practical P2P environments. This paper describes the construction of an extended prisoner's dilemma game on square lattice networks with three strategies, i.e., defection, unconditional cooperation, and reciprocal cooperation. Reciprocators discriminate partners according to their reputations based on image scoring, where mistakes in judgment of reputations may occur. The independent structures of interaction and learning neighborhood are discussed, with respect to the situation in which learning environments differ from interaction networks. The simulation results have indicated that the incentive mechanism enhances cooperation better in structured peers than among a well-mixed population. Given the realistic condition of inaccurate reputation scores, defection is still successfully held down when the players interact and learn within the unified neighborhoods. Extensive simulations have further confirmed the positive impact of spatial structure on cooperation with different sizes of lattice neighborhoods. And similar conclusions can also be drawn on regular random networks and scale-free networks. Moreover, for the separated structures of the neighborhoods, the interaction network has a critical effect on the evolution dynamics of cooperation and learning environments only have weaker impacts on the process. Our findings further provide some insights concerning the evolution of collective behaviors in social systems.

  17. The family of K2P channels: salient structural and functional properties

    PubMed Central

    Feliciangeli, Sylvain; Chatelain, Frank C; Bichet, Delphine; Lesage, Florian

    2015-01-01

    Potassium channels participate in many biological functions, from ion homeostasis to generation and modulation of the electrical membrane potential. They are involved in a large variety of diseases. In the human genome, 15 genes code for K+ channels with two pore domains (K2P). These channels form dimers of pore-forming subunits that produce background conductances finely regulated by a range of natural and chemical effectors, including signalling lipids, temperature, pressure, pH, antidepressants and volatile anaesthetics. Since the cloning of TWIK1, the prototypical member of this family, a lot of work has been carried out on their structure and biology. These studies are still in progress, but data gathered so far show that K2P channels are central players in many processes, including ion homeostasis, hormone secretion, cell development and excitability. A growing number of studies underline their implication in physiopathological mechanisms, such as vascular and pulmonary hypertension, cardiac arrhythmias, nociception, neuroprotection and depression. This review gives a synthetic view of the most noticeable features of these channels. PMID:25530075

  18. TASK-2: a K2P K+ channel with complex regulation and diverse physiological functions

    PubMed Central

    Cid, L. Pablo; Roa-Rojas, Hugo A.; Niemeyer, María I.; González, Wendy; Araki, Masatake; Araki, Kimi; Sepúlveda, Francisco V.

    2013-01-01

    TASK-2 (K2P5.1) is a two-pore domain K+ channel belonging to the TALK subgroup of the K2P family of proteins. TASK-2 has been shown to be activated by extra- and intracellular alkalinization. Extra- and intracellular pH-sensors reside at arginine 224 and lysine 245 and might affect separate selectivity filter and inner gates respectively. TASK-2 is modulated by changes in cell volume and a regulation by direct G-protein interaction has also been proposed. Activation by extracellular alkalinization has been associated with a role of TASK-2 in kidney proximal tubule bicarbonate reabsorption, whilst intracellular pH-sensitivity might be the mechanism for its participation in central chemosensitive neurons. In addition to these functions TASK-2 has been proposed to play a part in apoptotic volume decrease in kidney cells and in volume regulation of glial cells and T-lymphocytes. TASK-2 is present in chondrocytes of hyaline cartilage, where it is proposed to play a central role in stabilizing the membrane potential. Additional sites of expression are dorsal root ganglion neurons, endocrine and exocrine pancreas and intestinal smooth muscle cells. TASK-2 has been associated with the regulation of proliferation of breast cancer cells and could become target for breast cancer therapeutics. Further work in native tissues and cells together with genetic modification will no doubt reveal the details of TASK-2 functions that we are only starting to suspect. PMID:23908634

  19. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states.

    PubMed

    McClenaghan, Conor; Schewe, Marcus; Aryal, Prafulla; Carpenter, Elisabeth P; Baukrowitz, Thomas; Tucker, Stephen J

    2016-06-01

    The TREK subfamily of two-pore domain (K2P) K(+) channels exhibit polymodal gating by a wide range of physical and chemical stimuli. Crystal structures now exist for these channels in two main states referred to as the "up" and "down" conformations. However, recent studies have resulted in contradictory and mutually exclusive conclusions about the functional (i.e., conductive) status of these two conformations. To address this problem, we have used the state-dependent TREK-2 inhibitor norfluoxetine that can only bind to the down state, thereby allowing us to distinguish between these two conformations when activated by different stimuli. Our results reconcile these previously contradictory gating models by demonstrating that activation by pressure, temperature, voltage, and pH produce more than one structurally distinct open state and reveal that channel activation does not simply involve switching between the up and down conformations. These results also highlight the diversity of structural mechanisms that K2P channels use to integrate polymodal gating signals. PMID:27241700

  20. Suppressed Charmed B Decay

    SciTech Connect

    Snoek, Hella Leonie

    2009-06-02

    This thesis describes the measurement of the branching fractions of the suppressed charmed B0 → D*- a0+ decays and the non-resonant B0 → D*- ηπ+ decays in approximately 230 million Υ(4S) → B$\\bar{B}$ events. The data have been collected with the BABAR detector at the PEP-II B factory at the Stanford Linear Accelerator Center in California. Theoretical predictions of the branching fraction of the B0 → D*- a{sub 0}+ decays show large QCD model dependent uncertainties. Non-factorizing terms, in the naive factorization model, that can be calculated by QCD factorizing models have a large impact on the branching fraction of these decay modes. The predictions of the branching fractions are of the order of 10-6. The measurement of the branching fraction gives more insight into the theoretical models. In general a better understanding of QCD models will be necessary to conduct weak interaction physics at the next level. The presence of CP violation in electroweak interactions allows the differentiation between matter and antimatter in the laws of physics. In the Standard Model, CP violation is incorporated in the CKM matrix that describes the weak interaction between quarks. Relations amongst the CKM matrix elements are used to present the two relevant parameters as the apex of a triangle (Unitarity Triangle) in a complex plane. The over-constraining of the CKM triangle by experimental measurements is an important test of the Standard Model. At this moment no stringent direct measurements of the CKM angle γ, one of the interior angles of the Unitarity Triangle, are available. The measurement of the angle γ can be performed using the decays of neutral B mesons. The B0 → D*- a0+ decay is sensitive to the angle γ and, in comparison to the current decays that are being employed, could significantly

  1. Decay of superdeformed bands

    SciTech Connect

    Carpenter, M.P.; Khoo, T.L.; Lauritsen, T.

    1995-12-31

    One of the major challenges in the study of superdeformation is to directly connect the large number of superdeformed bands now known to the yrast states. In this way, excitation energies, spins and parities can be assigned to the levels in the second well which is essential to establish the collective and single-particle components of these bands. This paper will review some of the progress which has been made to understand the decay of superdeformed bands using the new arrays including the measurement of the total decay spectrum and the establishment of direct one-step decays from the superdeformed band to the yrast line in {sup 194}Hg. 42 refs., 5 figs.

  2. Kinetics of Radioactive Decay

    NASA Astrophysics Data System (ADS)

    Nagy, S.

    At present there are over 3,000 known nuclides (see the Appendix in Vol. 2 on the “Table of the Nuclides”), 265 of which are stable, while the rest, i.e., more than 90% of them, are radioactive. The chemical applications of the specific isotopes of chemical elements are mostly connected with the latter group, including quite a number of metastable nuclear isomers, making the kinetics of radioactive decay an important chapter of nuclear chemistry. After giving a phenomenological and then a statistical interpretation of the exponential law, the various combinations of individual decay processes as well as the cases of equilibrium and nonequilibrium will be discussed. Half-life systematics of the different decay modes detailed in Chaps. 2 and 4 of this volume are also summarized.

  3. The splitting and oscillator strengths for the 2S/2/S-2p/2/P/0/ doublet in lithium-like sulfur. [during Skylab observed solar flares

    NASA Technical Reports Server (NTRS)

    Pegg, D. J.; Forester, J. P.; Elston, S. B.; Griffin, P. M.; Peterson, R. S.; Thoe, R. S.; Vane, C. R.; Sellin, I. A.; Groeneveld, K.-O.

    1977-01-01

    The beam-foil technique has been used to study the 2S(2)S-2p(2)P(0) doublet in S XIV. The results confirm the doublet splitting measured aboard Skylab during solar flare events. In addition, the oscillator strengths for the resonance transitions comprising this doublet have been measured and found to agree well with recent relativistic f-value calculations.

  4. Weak decay of hypernuclei

    SciTech Connect

    Grace, R.

    1983-01-01

    The Moby Dick spectrometer (at BNL) in coincidence with a range spectrometer and a TOF neutron detector will be used to study the weak decay modes of /sup 12/C. The Moby Dick spectrometer will be used to reconstruct and tag events in which specific hypernuclear states are formed in the reaction K/sup -/ + /sup 12/C ..-->.. ..pi../sup -/ + /sup 12/C. Subsequent emission of decay products (pions, protons and neutrons) in coincidence with the fast forward pion will be detected in a time and range spectrometer, and a neutron detector.

  5. Search for the decay

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Adeva, B.; Adinolfi, M.; Affolder, A.; Ajaltouni, Z.; Akar, S.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; An, L.; Anderlini, L.; Anderson, J.; Andreotti, M.; Andrews, J. E.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; d'Argent, P.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Baalouch, M.; Bachmann, S.; Back, J. J.; Badalov, A.; Baesso, C.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Batozskaya, V.; Battista, V.; Bay, A.; Beaucourt, L.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Bel, L. J.; Belyaev, I.; Ben-Haim, E.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bertolin, A.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Birnkraut, A.; Bizzeti, A.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borsato, M.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Braun, S.; Brett, D.; Britsch, M.; Britton, T.; Brodzicka, J.; Brook, N. H.; Bursche, A.; Buytaert, J.; Cadeddu, S.; Calabrese, R.; Calvi, M.; Calvo Gomez, M.; Campana, P.; Campora Perez, D.; Capriotti, L.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carniti, P.; Carson, L.; Carvalho Akiba, K.; Casanova Mohr, R.; Casse, G.; Cassina, L.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Cavallero, G.; Cenci, R.; Charles, M.; Charpentier, Ph.; Chefdeville, M.; Chen, S.; Cheung, S.-F.; Chiapolini, N.; Chrzaszcz, M.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coco, V.; Cogan, J.; Cogneras, E.; Cogoni, V.; Cojocariu, L.; Collazuol, G.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Corvo, M.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Crocombe, A.; Cruz Torres, M.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; Dalseno, J.; David, P. N. Y.; Davis, A.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Dean, C.-T.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Déléage, N.; Derkach, D.; Deschamps, O.; Dettori, F.; Dey, B.; Di Canto, A.; Di Ruscio, F.; Dijkstra, H.; Donleavy, S.; Dordei, F.; Dorigo, M.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dreimanis, K.; Dujany, G.; Dupertuis, F.; Durante, P.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Ely, S.; Esen, S.; Evans, H. M.; Evans, T.; Falabella, A.; Färber, C.; Farinelli, C.; Farley, N.; Farry, S.; Fay, R.; Ferguson, D.; Fernandez Albor, V.; Ferrari, F.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fiorini, M.; Firlej, M.; Fitzpatrick, C.; Fiutowski, T.; Fol, P.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Fu, J.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gallorini, S.; Gambetta, S.; Gandelman, M.; Gandini, P.; Gao, Y.; García Pardiñas, J.; Garofoli, J.; Garra Tico, J.; Garrido, L.; Gascon, D.; Gaspar, C.; Gastaldi, U.; Gauld, R.; Gavardi, L.; Gazzoni, G.; Geraci, A.; Gerick, D.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gianelle, A.; Gianì, S.; Gibson, V.; Giubega, L.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gotti, C.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graverini, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Griffith, P.; Grillo, L.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hamilton, B.; Hampson, T.; Han, X.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; He, J.; Head, T.; Heijne, V.; Hennessy, K.; Henrard, P.; Henry, L.; Hernando Morata, J. A.; van Herwijnen, E.; Heß, M.; Hicheur, A.; Hill, D.; Hoballah, M.; Hombach, C.; Hulsbergen, W.; Humair, T.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jalocha, J.; Jans, E.; Jawahery, A.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Jurik, N.; Kandybei, S.; Kanso, W.; Karacson, M.; Karbach, T. M.; Karodia, S.; Kelsey, M.; Kenyon, I. R.; Kenzie, M.; Ketel, T.; Khanji, B.; Khurewathanakul, C.; Klaver, S.; Klimaszewski, K.; Kochebina, O.; Kolpin, M.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucewicz, W.; Kucharczyk, M.; Kudryavtsev, V.; Kurek, K.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanfranchi, G.; Langenbruch, C.; Langhans, B.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Likhomanenko, T.; Liles, M.; Lindner, R.; Linn, C.; Lionetto, F.; Liu, B.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lucchesi, D.; Lucio Martinez, M.; Luo, H.; Lupato, A.; Luppi, E.; Lupton, O.; Machefert, F.; Maciuc, F.; Maev, O.; Malde, S.; Malinin, A.; Manca, G.; Mancinelli, G.; Manning, P.; Mapelli, A.; Maratas, J.; Marchand, J. F.; Marconi, U.; Marin Benito, C.; Marino, P.; Märki, R.; Marks, J.; Martellotti, G.; Martinelli, M.; Martinez Santos, D.; Martinez Vidal, F.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathad, A.; Mathe, Z.; Matteuzzi, C.; Matthieu, K.; Mauri, A.; Maurin, B.; Mazurov, A.; McCann, M.; McCarthy, J.; McNab, A.; McNulty, R.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D. A.; Minard, M.-N.; Mitzel, D. S.; Molina Rodriguez, J.; Monteil, S.; Morandin, M.; Morawski, P.; Mordà, A.; Morello, M. J.; Moron, J.; Morris, A. B.; Mountain, R.; Muheim, F.; Müller, J.; Müller, K.; Müller, V.; Mussini, M.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neri, N.; Neubert, S.; Neufeld, N.; Neuner, M.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Ninci, D.; Novoselov, A.; O'Hanlon, D. P.; Oblakowska-Mucha, A.; Obraztsov, V.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Onderwater, C. J. G.; Osorio Rodrigues, B.; Otalora Goicochea, J. M.; Otto, A.; Owen, P.; Oyanguren, A.; Palano, A.; Palombo, F.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Pappalardo, L. L.; Parkes, C.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrignani, C.; Pearce, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perret, P.; Pescatore, L.; Petridis, K.; Petrolini, A.; Petruzzo, M.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Pistone, A.; Playfer, S.; Plo Casasus, M.; Poikela, T.; Polci, F.; Poluektov, A.; Polyakov, I.; Polycarpo, E.; Popov, A.; Popov, D.; Popovici, B.; Potterat, C.; Price, E.; Price, J. D.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Quagliani, R.; Rachwal, B.; Rademacker, J. H.; Rakotomiaramanana, B.; Rama, M.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redi, F.; Reichert, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, S.; Rihl, M.; Rinnert, K.; Rives Molina, V.; Robbe, P.; Rodrigues, A. B.; Rodrigues, E.; Rodriguez Lopez, J. A.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rotondo, M.; Rouvinet, J.; Ruf, T.; Ruiz, H.; Ruiz Valls, P.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salustino Guimaraes, V.; Sanchez Mayordomo, C.; Sanmartin Sedes, B.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sarti, A.; Satriano, C.; Satta, A.; Saunders, D. M.; Savrina, D.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmelzer, T.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Semennikov, A.; Sepp, I.; Serra, N.; Serrano, J.; Sestini, L.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, V.; Shires, A.; Silva Coutinho, R.; Simi, G.; Sirendi, M.; Skidmore, N.; Skillicorn, I.; Skwarnicki, T.; Smith, E.; Smith, E.; Smith, J.; Smith, M.; Snoek, H.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; Souza De Paula, B.; Spaan, B.; Spradlin, P.; Sridharan, S.; Stagni, F.; Stahl, M.; Stahl, S.; Steinkamp, O.; Stenyakin, O.; Sterpka, F.; Stevenson, S.; Stoica, S.; Stone, S.; Storaci, B.; Stracka, S.; Straticiuc, M.; Straumann, U.; Stroili, R.; Sun, L.; Sutcliffe, W.; Swientek, K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Tekampe, T.; Teklishyn, M.; Tellarini, G.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Todd, J.; Tolk, S.; Tomassetti, L.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Trabelsi, K.; Tran, M. T.; Tresch, M.; Trisovic, A.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ukleja, A.; Ustyuzhanin, A.; Uwer, U.; Vacca, C.; Vagnoni, V.; Valenti, G.; Vallier, A.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vázquez Sierra, C.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vieites Diaz, M.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; de Vries, J. A.; Waldi, R.; Wallace, C.; Wallace, R.; Walsh, J.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Websdale, D.; Weiden, A.; Whitehead, M.; Wiedner, D.; Wilkinson, G.; Wilkinson, M.; Williams, M.; Williams, M. P.; Williams, M.; Wilson, F. F.; Wimberley, J.; Wishahi, J.; Wislicki, W.; Witek, M.; Wormser, G.; Wotton, S. A.; Wright, S.; Wyllie, K.; Xie, Y.; Xu, Z.; Yang, Z.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, L.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.

    2015-08-01

    A search for decays is performed using 3 .0 fb1- of pp collision data recorded by the LHCb experiment during 2011 and 2012. The f 0(980) meson is reconstructed through its decay to the π + π - final state in the mass window 900 MeV /c 2 < m( π + π -) < 1080 MeV /c 2. No significant signal is observed. The first upper limits on the branching fraction of are set at 90 % (95 %) confidence level. [Figure not available: see fulltext.

  6. Attractor Explosions and Catalyzed Vacuum Decay

    SciTech Connect

    Green, Daniel; Silverstein, Eva; Starr, David

    2006-05-05

    We present a mechanism for catalyzed vacuum bubble production obtained by combining moduli stabilization with a generalized attractor phenomenon in which moduli are sourced by compact objects. This leads straightforwardly to a class of examples in which the Hawking decay process for black holes unveils a bubble of a different vacuum from the ambient one, generalizing the new endpoint for Hawking evaporation discovered recently by Horowitz. Catalyzed vacuum bubble production can occur for both charged and uncharged bodies, including Schwarzschild black holes for which massive particles produced in the Hawking process can trigger vacuum decay. We briefly discuss applications of this process to the population and stability of metastable vacua.

  7. BABAR B Decay Results

    SciTech Connect

    MacFarlane, David B

    2002-03-14

    Data from the first run of the BABAR detector at the PEP II accelerator are presented. Measurements of many rare B decay modes are now possible using the large data sets currently being collected by BABAR. An overview of analysis techniques and results on data collected in 2000 are described.

  8. Cosmology with decaying particles

    SciTech Connect

    Turner, M.S.

    1984-09-01

    We consider a cosmological model in which an unstable massive relic particle species (denoted by X) has an initial mass density relative to baryons ..beta../sup -1/ identically equal rho/sub X//rho/sub B/ >> 1, and then decays recently (redshift z less than or equal to 1000) into particles which are still relativistic today (denoted by R). We write down and solve the coupled equations for the cosmic scale factor a(t), the energy density in the various components (rho/sub X/, rho/sub R/, rho/sub B/), and the growth of linear density perturbations (delta rho/rho). The solutions form a one parameter (..beta..) family of solutions; physically ..beta../sup -1/ approx. = (..cap omega../sub R//..cap omega../sub NR/) x (1 + z/sub D/) = (ratio today of energy density of relativistic to nonrelativistic particles) x (1 + redshift of (decay)). We discuss the observational implications of such a cosmological model and compare our results to earlier results computed in the simultaneous decay approximation. In an appendix we briefly consider the case where one of the decay products of the X is massive and becomes nonrelativistic by the present epoch. 21 references.

  9. Semileptonic B Meson Decays

    SciTech Connect

    Luth, Vera G.; /SLAC

    2012-01-03

    Semileptonic decays of B mesons play a critical role in the determination of the magnitude of the Cabibbo-Kobayashi-Maskawa (CKM) matrix elements V{sub cb} and V{sub ub}. These two quantities are fundamental parameters of the Standard Model and have to be determined experimentally. Over the past decade, the vast samples of B mesons recorded at the B factories at LEP at Cornell University, KEK at Tsukuba, and SLAC at Stanford University have allowed for detailed studies of semileptonic B decays. These decays proceed via first-order weak interactions; thus, they are expected to be free of non-Standard Model contributions and therefore are well suited for the extraction of the quark-mixing parameters. Differential decay rates are combined with theoretical calculations of hadronization effects, leading to a substantially improved knowledge of |V{sub cb}| and |V{sub ub}|. The results are used to constrain the parameters of the CKM matrix and to test the Standard Model predictions for CP-violating effects.

  10. Decay Time of Cathodoluminescence

    ERIC Educational Resources Information Center

    Kraftmakher, Yaakov

    2009-01-01

    Simple measurements of the decay time of cathodoluminescence are described. Cathodoluminescence is used in many devices, including computer monitors, oscilloscopes, radar displays and television tubes. The experimental setup is simple and easy to build. Two oscilloscopes, a function generator, and a fast photodiode are needed for the experiments.…

  11. Tooth decay - early childhood

    MedlinePlus

    Bottle mouth; Bottle carries; Baby bottle tooth decay; Early childhood caries (ECC) ... Your child needs strong, healthy baby teeth to chew food and to talk. Baby teeth also make space in children's jaws for their adult teeth to grow in straight. ...

  12. Observation of the Forbidden Magnetic Dipole Transition 6{sup 2}P{sub ½} --> 7{sup 2}P{sub ½} in Atomic Thallium

    DOE R&D Accomplishments Database

    Chu, S.

    1976-10-01

    A measurement of the 6{sup 2}P{sub ½} --> 7{sup 2}P{sub ½} forbidden magnetic dipole matrix element in atomic thallium is described. A pulsed, linearly polarized dye laser tuned to the transition frequency is used to excite the thallium vapor from the 6{sup 2}P{sub ½} ground state to the 7{sup 2}P{sub ½} excited state. Interference between the magnetic dipole M1 amplitude and a static electric field induced E1 amplitude results in an atomic polarization of the 7{sup 2}P{sub ½} state, and the subsequent circular polarization of 535 nm fluorescence. The circular polarization is seen to be proportional to / as expected, and measured for several transitions between hyperfine levels of the 6{sup 2}P{sub ½} and 7{sup 2}P{sub ½} states. The result is = -(2.11 +- 0.30) x 10{sup -5} parallel bar e parallel bar dirac constant/2mc, in agreement with theory.

  13. New superhindered polydentate polyphosphine ligands P(CH2CH2P(t)Bu2)3, PhP(CH2CH2P(t)Bu2)2, P(CH2CH2CH2P(t)Bu2)3, and their ruthenium(II) chloride complexes.

    PubMed

    Gilbert-Wilson, Ryan; Field, Leslie D; Bhadbhade, Mohan M

    2012-03-01

    The synthesis and characterization of the extremely hindered phosphine ligands, P(CH(2)CH(2)P(t)Bu(2))(3) (P(2)P(3)(tBu), 1), PhP(CH(2)CH(2)P(t)Bu(2))(2) (PhP(2)P(2)(tBu), 2), and P(CH(2)CH(2)CH(2)P(t)Bu(2))(3) (P(3)P(3)(tBu), 3) are reported, along with the synthesis and characterization of ruthenium chloro complexes RuCl(2)(P(2)P(3)(tBu)) (4), RuCl(2)(PhP(2)P(2)(tBu)) (5), and RuCl(2)(P(3)P(3)(tBu)) (6). The bulky P(2)P(3)(tBu) (1) and P(3)P(3)(tBu) (3) ligands are the most sterically encumbered PP(3)-type ligands so far synthesized, and in all cases, only three phosphorus donors are able to bind to the metal center. Complexes RuCl(2)(PhP(2)P(2)(tBu)) (5) and RuCl(2)(P(3)P(3)(tBu)) (6) were characterized by crystallography. Low temperature solution and solid state (31)P{(1)H} NMR were used to demonstrate that the structure of RuCl(2)(P(2)P(3)(tBu)) (4) is probably analogous to that of RuCl(2)(PhP(2)P(2)(tBu)) (5) which had been structurally characterized.

  14. Anatomy of decays

    NASA Astrophysics Data System (ADS)

    Bel, Lennaert; De Bruyn, Kristof; Fleischer, Robert; Mulder, Mick; Tuning, Niels

    2015-07-01

    The decays B {/d 0} → D {/d -} D {/d +} and B {/s 0} → D {/s -} D {/s +} probe the CP-violating mixing phases ϕ d and ϕ s , respectively. The theoretical uncertainty of the corresponding determinations is limited by contributions from penguin topologies, which can be included with the help of the U-spin symmetry of the strong interaction. We analyse the currently available data for B {/d, s 0} → D {/d, s -} D {/d, s +} decays and those with similar dynamics to constrain the involved non-perturbative parameters. Using further information from semileptonic B {/d 0} → D {/d -} ℓ + ν ℓ decays, we perform a test of the factorisation approximation and take non-factorisable SU(3)-breaking corrections into account. The branching ratios of the B {/d 0} → D {/d -} D {/d +}, B {/s 0} → D {/s -} D {/d +} and B {/s 0} → D {/s -} D {/s +}, B {/d 0} → D {/d -} D {/s +} decays show an interesting pattern which can be accommodated through significantly enhanced exchange and penguin annihilation topologies. This feature is also supported by data for the B {/s 0} → D {/d -} D {/d +} channel. Moreover, there are indications of potentially enhanced penguin contributions in the B {/d 0} → D {/d -} D {/d +} and B {/s 0} → D {/s -} D {/s +} decays, which would make it mandatory to control these effects in the future measurements of ϕ d and ϕ s . We discuss scenarios for high-precision measurements in the era of Belle II and the LHCb upgrade.

  15. Magnetorotational decay instability in Keplerian disks.

    PubMed

    Shtemler, Yuri; Liverts, Edward; Mond, Michael

    2013-12-01

    The saturation of the magnetorotational instability (MRI) in thin Keplerian disks through three-wave resonant interactions is introduced and discussed. That mechanism is a natural generalization of the fundamental decay instability discovered five decades ago for infinite, homogeneous, and immovable plasmas. The decay instability relies on the energy transfer from the MRI to stable slow Alfvén-Coriolis as well as magnetosonic waves. A second-order forced Duffing amplitude equation for the initially unstable MRI as well as two first-order equations for the other two waves are derived. The solutions of those equations exhibit bounded bursty nonlinear oscillations for the MRI as well as unbounded growth for the linearly stable slow Alfvén-Coriolis and magnetosonic perturbations, thus giving rise to the magnetorotational decay instability. PMID:24476249

  16. Classical trajectory study of alignment effects in the capture process: He 2+-Li ∗(2pΣ,2pΠ) collisions

    NASA Astrophysics Data System (ADS)

    Perumal, A. N.; Tripathi, D. N.

    1998-08-01

    A simulation method (CTMC) has been used to investigate the selectivity and alignment effects on the capture process in He 2+-Li ∗(2pΣ,2pΠ) collisions. The anomalous results of the experiment (∼ 50% error) as well as the AO calculation of Gieler et al. in case of capture into He II ( n = 4) from the initial Li ∗ (2pΣ) state are not found in the present work. Relative velocity and spatial overlap together mainly control the capture process in ion-atom collisions. The n-distribution of the final capture state is also presented.

  17. Evolutionary divergence of Ure2pA glutathione transferases in wood degrading fungi.

    PubMed

    Roret, Thomas; Thuillier, Anne; Favier, Frédérique; Gelhaye, Eric; Didierjean, Claude; Morel-Rouhier, Mélanie

    2015-10-01

    The intracellular systems of detoxification are crucial for the survival of wood degrading fungi. Within these systems, glutathione transferases could play a major role since this family of enzymes is specifically extended in lignolytic fungi. In particular the Ure2p class represents one third of the total GST number in Phanerochaete chrysosporium. These proteins have been phylogenetically split into two subclasses called Ure2pA and Ure2pB. Ure2pB can be classified as Nu GSTs because of shared structural and functional features with previously characterized bacterial isoforms. Ure2pA can rather be qualified as Nu-like GSTs since they exhibit a number of differences. Ure2pA possess a classical transferase activity, a more divergent catalytic site and a higher structural flexibility for some of them, compared to Nu GSTs. The characterization of four members of this Ure2pA subclass (PcUre2pA4, PcUre2pA5, PcUre2pA6 and PcUre2pA8) revealed specific functional and structural features, suggesting that these enzymes have rapidly evolved and differentiated, probably to adapt to the complex chemical environment associated with wood decomposition.

  18. Influence of chemical bonds on the lifetime of the molecular-field-split 2p levels in H{sub 2}S

    SciTech Connect

    Bueno, Andre Machado; Brito, Arnaldo Naves de; Fink, Reinhold F.; Baessler, Margit; Bjoerneholm, Olle; Burmeister, Florian; Feifel, Raimund; Miron, Catalin; Sorensen, Stacey L.; Wang Honghong; Svensson, Svante

    2003-02-01

    Different lifetime broadenings in molecular-field-split 2p core levels in H{sub 2}S are predicted theoretically and are identified in an experimental investigation of the S 2p Auger electron spectrum. The measurements were performed for the transition to the vibrationally resolved X{sup 1}A{sub 1} ground state of H{sub 2}S{sup 2+}. The lifetimes of the 3e{sub 1/2} and 5e{sub 1/2} levels of the 2p ionized molecule are found to be 64 and 74 meV, respectively. This unambiguous determination of the lifetime difference of 10{+-}1 meV is only possible as the 4e{sub 1/2}{yields}X{sup 1}A{sub 1}(2b{sub 1}{sup -2}) decay channel that overlaps the 5e{sub 1/2}{yields}X{sup 1}A{sub 1}(2b{sub 1}{sup -2}) channel is practically suppressed in Auger decay in H{sub 2}S. The lifetime difference is confirmed by ab initio calculations. A theoretical analysis shows that it results from the mutual orientation of the core hole in the intermediate states and the valence electron density in the sulfur 3p orbitals. Both are strongly influenced by the chemical bond. Thus the observed effect is the direct result of a fundamental property of molecular electronic structure.

  19. Molecular identification of the dominant-negative, splicing isoform of the two-pore domain K(+) channel K(2P)5.1 in lymphoid cells and enhancement of its expression by splicing inhibition.

    PubMed

    Endo, Kyoko; Kurokawa, Natsumi; Kito, Hiroaki; Nakakura, Sawa; Fujii, Masanori; Ohya, Susumu

    2015-12-01

    The two-pore domain background K(+) channel K2P5.1 is expected as a possible therapeutic target for autoimmune and inflammatory disorders and cancers because it plays an important role in maintaining the resting membrane potential and regulation of Ca(2+) signaling in T lymphocytes and cancer cells. However, the lack of selective K2P5.1 blockers has led to difficulties conducting experimental studies on this K(+) channel. We identified a novel splicing isoform of K2P5.1, K2P5.1B from the mammalian spleen, which lacked the N-terminus of full-length K2P5.1A. A co-immunoprecipitation assay using mice spleen lysates revealed an interaction between K2P5.1A and K2P5.1B in the cytoplasmic C-terminal domain. In a heterologous HEK293 expression system, K2P5.1B inhibited the trafficking of K2P5.1A to the plasma membrane. The alkaline pHe-induced hyperpolarizing response was significantly suppressed in K2P5.1B-transfected human leukemia K562 cells. Enhancement in cell proliferation by the overexpression of K2P5.1A in K562 was significantly prevented by the transfection of K2P5.1B. The spliceosome inhibitor pladienolide B significantly enhanced the relative expression of K2P5.1B in K562, resulting in decreases in the activity of K2P5.1A. K2P5.1B suppresses the function of the K2P5.1 K(+) channel in a dominant-negative manner, suggesting that the mRNA splicing mechanisms underlying the transcriptional regulation of K2P5.1B may be a new therapeutic strategy for autoimmune and inflammatory disorders and cancers. PMID:26475531

  20. B Decays Involving Light Mesons

    NASA Astrophysics Data System (ADS)

    Eschrich, Ivo Gough

    Recent BABAR results for decays of B-mesons to combinations of non-charm mesons are presented. This includes B decays to two vector mesons, B → η‧(π, K, ρ) modes, and a comprehensive Dalitz Plot analysis of B → KKK decays.

  1. B Decays Involving Light Mesons

    SciTech Connect

    Eschrich, Ivo Gough; /UC, Irvine

    2007-01-09

    Recent BABAR results for decays of B-mesons to combinations of non-charm mesons are presented. This includes B decays to two vector mesons, B {yields} {eta}{prime}({pi}, K, {rho}) modes, and a comprehensive Dalitz Plot analysis of B {yields} KKK decays.

  2. Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo study of the PB1 domain of Ref(2)P.

    PubMed

    Carré-Mlouka, A; Gaumer, S; Gay, P; Petitjean, A M; Coulondre, C; Dru, P; Bras, F; Dezélée, S; Contamine, D

    2007-05-01

    Ref(2)P has been described as one of the Drosophila proteins that interacts with the sigma virus cycle. We generated alleles to identify critical residues involved in the restrictive (inhibiting viral multiplication) or permissive (allowing viral multiplication) character of Ref(2)P. We demonstrate that permissive alleles increase the ability of the sigma virus to infect Drosophila when compared to null alleles and we confirm that restrictive alleles decrease this capacity. Moreover, we have created alleles unfunctional in viral cycling while functional for Ref(2)P fly functions. This type of allele had never been observed before and shows that fly- and virus-related activities of Ref(2)P are separable. The viral status of Ref(2)P variants is determined by the amino-terminal PB1 domain polymorphism. In addition, an isolated PB1 domain mimics virus-related functions even if it is similar to a loss of function toward fly-related activities. The evolutionary tree of the Ref(2)P PB1 domain that we could build on the basis of the natural allele sequences is in agreement with an evolution of PB1 domain due to successive transient selection waves.

  3. Radiative and non radiative decay of electronically excited HNF (DNF)

    SciTech Connect

    Chen, J.; Dagdigian, P.J.

    1993-12-31

    Laser experiments probing the dynamics of the decay of electronically excited HNF/DNF({tilde A}{sup 2}A`) will be reported. Measured decay lifetimes of individual (J`,K) excited levels revealed the onset of a rapid nonradiative decay process at a threshold energy of 23,800 {+-} 500 cm{sup {minus}1} above the HNF({tilde X}{sup 2}A``) zero-point level. The assignment of this threshold to the predissociation process, HNF/DNF{sup *} {yields} NH/ND(X{sup 3}{Sigma}{sup {minus}}) + F({sup 2}P), has been confirmed by direct observation of the NH/ND fragment. Photofragmentation excitation spectra, which exhibits strong mixing between the excited and ground electronic states, will be presented and discussed.

  4. Decay Dynamics of Tumors

    PubMed Central

    2016-01-01

    The fractional cell kill is a mathematical expression describing the rate at which a certain population of cells is reduced to a fraction of itself. We investigate the mathematical function that governs the rate at which a solid tumor is lysed by a cell population of cytotoxic lymphocytes. We do it in the context of enzyme kinetics, using geometrical and analytical arguments. We derive the equations governing the decay of a tumor in the limit in which it is plainly surrounded by immune cells. A cellular automaton is used to test such decay, confirming its validity. Finally, we introduce a modification in the fractional cell kill so that the expected dynamics is attained in the mentioned limit. We also discuss the potential of this new function for non-solid and solid tumors which are infiltrated with lymphocytes. PMID:27310010

  5. PyDecay/GraphPhys: A Unified Language and Storage System for Particle Decay Process Descriptions

    SciTech Connect

    Dunietz, Jesse N.; /MIT /SLAC

    2011-06-22

    To ease the tasks of Monte Carlo (MC) simulation and event reconstruction (i.e. inferring particle-decay events from experimental data) for long-term BaBar data preservation and analysis, the following software components have been designed: a language ('GraphPhys') for specifying decay processes, common to both simulation and data analysis, allowing arbitrary parameters on particles, decays, and entire processes; an automated visualization tool to show graphically what decays have been specified; and a searchable database storage mechanism for decay specifications. Unlike HepML, a proposed XML standard for HEP metadata, the specification language is designed not for data interchange between computer systems, but rather for direct manipulation by human beings as well as computers. The components are interoperable: the information parsed from files in the specification language can easily be rendered as an image by the visualization package, and conversion between decay representations was implemented. Several proof-of-concept command-line tools were built based on this framework. Applications include building easier and more efficient interfaces to existing analysis tools for current projects (e.g. BaBar/BESII), providing a framework for analyses in future experimental settings (e.g. LHC/SuperB), and outreach programs that involve giving students access to BaBar data and analysis tools to give them a hands-on feel for scientific analysis.

  6. Amplification of 2p as a Genomic Marker for Transformation in Lymphoma

    PubMed Central

    Kwiecinska, Anna; Ichimura, Koichi; Berglund, Mattias; Dinets, Andrii; Sulaiman, Luqman; Collins, V Peter; Larsson, Catharina; Porwit, Anna; Lagercrantz, Svetlana Bajalica

    2014-01-01

    To outline further genetic mechanisms of transformation from follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL), we have performed whole genome array-CGH in 81 tumors from 60 patients [29 de novo DLBCL (dnDLBCL), 31 transformed DLBCL (tDLBCL), and 21 antecedent FL]. In 15 patients, paired tumor samples (primary FL and a subsequent tDLBCL) were available, among which three possessed more than two subsequent tumors, allowing us to follow specific genetic alterations acquired before, during, and after the transformation. Gain of 2p15–16.1 encompassing, among others, the REL, BCL11A, USP34, COMMD1, and OTX1 genes was found to be more common in the tDLBCL compared with dnDLBCL (P < 0.001). Furthermore, a high-level amplification of 2p15–16.1 was also detected in the FL stage prior to transformation, indicating its importance during the transformation event. Quantitative real-time PCR showed a higher level of amplification of REL, USP34, and COMMD1 (all involved in the NFκΒ-pathway) compared with BCL11A, which indicates that the altered genes disrupting the NFκΒ pathway may be the driver genes of transformation rather than the previously suggested BCL11A. Moreover, a 17q21.33 amplification was exclusively found in tDLBCL, never in FL (P < 0.04) or dnDLBCL, indicating an upregulation of genes of importance during the later phase of transformation. Taken together, our study demonstrates potential genomic markers for disease progression to clinically more aggressive forms. We also confirm the importance of the TP53-, CDKN2A-, and NFκΒ-pathways for the transformation from FL to DLBCL. © 2014 Wiley Periodicals, Inc. PMID:24832791

  7. Radioactive decay data tables

    SciTech Connect

    Kocher, D.C.

    1981-01-01

    The estimation of radiation dose to man from either external or internal exposure to radionuclides requires a knowledge of the energies and intensities of the atomic and nuclear radiations emitted during the radioactive decay process. The availability of evaluated decay data for the large number of radionuclides of interest is thus of fundamental importance for radiation dosimetry. This handbook contains a compilation of decay data for approximately 500 radionuclides. These data constitute an evaluated data file constructed for use in the radiological assessment activities of the Technology Assessments Section of the Health and Safety Research Division at Oak Ridge National Laboratory. The radionuclides selected for this handbook include those occurring naturally in the environment, those of potential importance in routine or accidental releases from the nuclear fuel cycle, those of current interest in nuclear medicine and fusion reactor technology, and some of those of interest to Committee 2 of the International Commission on Radiological Protection for the estimation of annual limits on intake via inhalation and ingestion for occupationally exposed individuals.

  8. Selenium Deficiency Reduces the Abundance of mRNA for Se-Dependent Glutathione Peroxidase 1 by a UGA-Dependent Mechanism Likely To Be Nonsense Codon-Mediated Decay of Cytoplasmic mRNA

    PubMed Central

    Moriarty, Patrick M.; Reddy, C. Channa; Maquat, Lynne E.

    1998-01-01

    ) under conditions of Se deprivation, the Sec codon reduces the abundance of cytoplasmic Se-GPx1 mRNA by a translation-dependent mechanism and (ii) there is no additional mechanism by which Se regulates Se-GPx1 mRNA production. These data suggest that the inefficient incorporation of Sec at the UGA codon during mRNA translation augments the nonsense-codon-mediated decay of cytoplasmic Se-GPx1 mRNA. PMID:9566912

  9. Reactivity of Hydrides FeH(2)(CO)(2)P(2) (P = Phosphites) with Aryldiazonium Cations: Preparation, Characterization, X-ray Crystal Structure, and Electrochemical Studies of Mono- and Binuclear Aryldiazenido Complexes.

    PubMed

    Albertin, Gabriele; Antoniutti, Stefano; Bacchi, Alessia; Barbera, Davide; Bordignon, Emilio; Pelizzi, Giancarlo; Ugo, Paolo

    1998-10-19

    Mono- and binuclear aryldiazenido complexes [Fe(ArN(2))(CO)(2)P(2)]BPh(4) (1-4) and [{Fe(CO)(2)P(2)}(2)(&mgr;-N(2)Ar-ArN(2))](BPh(4))(2) (5-8) [P = P(OEt)(3), PPh(OEt)(2), PPh(2)OEt, P(OPh)(3); Ar = C(6)H(5), 2-CH(3)C(6)H(4), 4-CH(3)C(6)H(4); Ar-Ar = 4,4'-C(6)H(4)-C(6)H(4), 4,4'-(2-CH(3))C(6)H(3)-C(6)H(3)(2-CH(3)), 4,4'-C(6)H(4)-CH(2)-C(6)H(4)] were prepared by allowing hydride species FeH(2)(CO)(2)P(2) to react with an excess of mono- (ArN(2))(BF(4)) or bis-aryldiazonium (N(2)Ar-ArN(2))(BF(4))(2) salts, respectively, at low temperature. A reaction path involving a hydride-aryldiazene intermediate [FeH(ArN=NH)(CO)(2)P(2)](+), which, through the loss of H(2), affords the final aryldiazenido complexes 1-8, is proposed. The compounds were characterized by (1)H and (31)P{(1)H} NMR spectroscopy (including (15)N isotopic substitution) and X-ray crystal structure determination. The complex [Fe(CO)(2){P(OEt)(3)}(2){&mgr;-4,4'-N(2)(2-CH(3))C(6)H(3)-C(6)H(3)(2-CH(3))N(2)}](BPh(4))(2) (5b) crystallizes in the space group P&onemacr; with a = 15.008(4) Å, b = 17.094(5) Å, c = 10.553(3) Å, alpha = 99.56(1) degrees, beta = 102.80(1) degrees, gamma = 65.30(1) degrees, and Z = 1. The structure is centrosymmetric and consists of binuclear cations with the two iron atoms in a quite regular trigonal bipyramidal environment, with the two CO in the equatorial and the two phosphites in the apical position, respectively. Aryldiazenido complexes 1-8 react with strong acids HX (X = Cl, CF(3)SO(3), CF(3)CO(2)) to give the corresponding aryldiazene derivatives, according to the equilibrium [Fe(ArN(2))(CO)(2)P(2)](+) + HX right harpoon over left harpoon [FeX(ArN=NH)(CO)(2)P(2)](+). Electrochemical studies of both mono- (1-4) and binuclear (5-8) compounds were undertaken, and a mechanism for oxidation and reduction processes is proposed.

  10. RADIATIVE PENGUIN DECAYS FROM BABAR

    SciTech Connect

    Eigen, Gerald

    2003-08-28

    Electroweak penguin decays provide a promising hunting ground for Physics beyond the Standard Model (SM). The decay B {yields} X{sub s}{gamma}, which proceeds through an electromagnetic penguin loop, already provides stringent constraints on the supersymmetric (SUSY) parameter space. The present data samples of {approx}1 x 10{sup 8} B{bar B} events allow to explore radiative penguin decays with branching fractions of the order of 10{sup -6} or less. In this brief report they discuss a study of B {yields} K*{ell}{sup +}{ell}{sup -} decay modes and a search for B {yields} {rho}({omega}){gamma} decays.

  11. Charmless b decays at CDF

    SciTech Connect

    Donega, Mauro; /Geneva U.

    2005-07-01

    The authors report on the charmless B decays measurements performed on 180 pb{sup -1} of data collected with the CDF II detector at the Fermilab Tevatron collider. This paper describes: the first observation of the decay mode B{sub s} {yields} K{sup +}K{sup -} and the measurement of the direct Cp asymmetry in the ({bar B}){sub d} {yields} K{sup {+-}}{pi}{sup {-+}} decay; the first evidence of the decay mode B{sub s} {yields} {phi}{phi} and the branching ratio and Cp asymmetry for the B{sup {+-}} {yields} {phi}K{sup {+-}} decay.

  12. The excitation and collisional deactivation of metastable N/2P/ atoms in auroras

    NASA Technical Reports Server (NTRS)

    Zipf, E. C.; Espy, P. J.; Boyle, C. F.

    1980-01-01

    The concentration and altitude distribution of metastable N(2P) atoms was measured in a diffuse IBC II(+) auroral arc. The dominant N(2P) source is shown to be the dissociative excitation of N2 by electron impact with a minor contribution from the dissociative recombination of N2(+) ions. The possibility that an ion-molecule process involving atomic oxygen and vibrationally excited N2(+) ions is a significant N(2P) source is examined. Values for the proportional yield of N(+), N(2P), N(2D), and N(4S) atoms from electron-impact dissociation of N2 under optically thick conditions are given.

  13. Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p.

    PubMed

    Otzen, Marleen; Rucktäschel, Robert; Thoms, Sven; Emmrich, Kerstin; Krikken, Arjen M; Erdmann, Ralf; van der Klei, Ida J

    2012-07-01

    During budding of yeast cells peroxisomes are distributed over mother cell and bud, a process that involves the myosin motor protein Myo2p and the peroxisomal membrane protein Inp2p. Here, we show that Pex19p, a peroxin implicated in targeting and complex formation of peroxisomal membrane proteins, also plays a role in peroxisome partitioning. Binding studies revealed that Pex19p interacts with the cargo-binding domain of Myo2p. We identified mutations in Myo2p that specifically reduced binding to Pex19p, but not to Inp2p. The interaction between Myo2p and Pex19p was also reduced by a mutation that blocked Pex19p farnesylation. Microscopy revealed that the Pex19p-Myo2p interaction is important for peroxisome inheritance, because mutations that affect this interaction hamper peroxisome inheritance in vivo. Together these data suggest that both Inp2p and Pex19p are required for proper association of peroxisomes to Myo2p.

  14. Calculation and evaluation of energy levels and radiative rates for 2s{sup 2}2p{sup 6}-2s2p{sup 6}np and 2s{sup 2}2p{sup 6}-2s{sup 2}2p{sup 5}nd(4{<=}n{<=}20) transitions in Cu XX

    SciTech Connect

    Zhang, Z.R.; Cheng, X.L.; Li, H.F.; Liu, Z.J.; Sun, X.W.

    2012-07-15

    Energy levels, oscillator strengths, and radiative rates have been calculated for 2s{sup 2}2p{sup 6}-2s2p{sup 6}np and 2s{sup 2}2p{sup 6}-2s{sup 2}2p{sup 5}nd transitions with 4{<=}n{<=}20 in Cu XX ions. In the calculations, the Flexible Atomic Code has been used, and systematic analysis and evaluation of the accuracy of the calculated results for the two types of transitions are also given with different indicators. It is shown that the results for the transitions with a 2s hole are greatly improved by using the present method comparing to those from RELAC code. Furthermore, our results show that the energy levels of the 2s2p{sup 6}(n+1)l and 2s{sup 2}2p{sup 5}(n+2)l configurations closely interact with those of the 2s2p{sup 6}np series and it is essential to include the 2s{sup 2}2p{sup 5}(n+1)l configurations in the calculations for the 2s{sup 2}2p{sup 5}nd series.

  15. Lifetime of inner-shell hole states of Ar (2p) and Kr (3d) using equation-of-motion coupled cluster method

    SciTech Connect

    Ghosh, Aryya; Vaval, Nayana; Pal, Sourav

    2015-07-14

    Auger decay is an efficient ultrafast relaxation process of core-shell or inner-shell excited atom or molecule. Generally, it occurs in femto-second or even atto-second time domain. Direct measurement of lifetimes of Auger process of single ionized and double ionized inner-shell state of an atom or molecule is an extremely difficult task. In this paper, we have applied the highly correlated complex absorbing potential-equation-of-motion coupled cluster (CAP-EOMCC) approach which is a combination of CAP and EOMCC approach to calculate the lifetime of the states arising from 2p inner-shell ionization of an Ar atom and 3d inner-shell ionization of Kr atom. We have also calculated the lifetime of Ar{sup 2+}(2p{sup −1}3p{sup −1}) {sup 1}D, Ar{sup 2+}(2p{sup −1}3p{sup −1}) {sup 1}S, and Ar{sup 2+}(2p{sup −1}3s{sup −1}) {sup 1}P double ionized states. The predicted results are compared with the other theoretical results as well as experimental results available in the literature.

  16. Investigation of Periodic Nuclear Decay Data with Spectral Analysis Techniques

    NASA Astrophysics Data System (ADS)

    Javorsek, D.; Sturrock, P.; Buncher, J.; Fischbach, E.; Gruenwald, T.; Hoft, A.; Horan, T.; Jenkins, J.; Kerford, J.; Lee, R.; Mattes, J.; Morris, D.; Mudry, R.; Newport, J.; Petrelli, M.; Silver, M.; Stewart, C.; Terry, B.; Willenberg, H.

    2009-12-01

    We provide the results from a spectral analysis of nuclear decay experiments displaying unexplained periodic fluctuations. The analyzed data was from 56Mn decay reported by the Children's Nutrition Research Center in Houston, 32Si decay reported by an experiment performed at the Brookhaven National Laboratory, and 226Ra decay reported by an experiment performed at the Physikalisch-Technische-Bundesanstalt in Germany. All three data sets possess the same primary frequency mode consisting of an annual period. Additionally a spectral comparison of the local ambient temperature, atmospheric pressure, relative humidity, Earth-Sun distance, and the plasma speed and latitude of the heliospheric current sheet (HCS) was performed. Following analysis of these six possible causal factors, their reciprocals, and their linear combinations, a possible link between nuclear decay rate fluctuations and the linear combination of the HCS latitude and 1/R motivates searching for a possible mechanism with such properties.

  17. Feeding and decay of superdeformed states

    SciTech Connect

    Khoo, T.L.; Lauritsen, T.; Ahmad, I.; Carpenter, M.P.; Fernandez, P.B.; Janssens, R.V.F.; Moore, E.F.; Wolfs, F.L.H.; Benet, Ph.; Daly, P.J.; Beard, K.B.; Garg, U.; Ye, D.; Drigert, M.W.

    1992-12-31

    The mechanisms for feeding and decay of superdeformed (SD) bands are examined. Data connected with both processes in {sup 192}Hg are compared with model calculations. The calculations successfully reproduce the data, suggesting that the mechanisms for both processes are understood. Constraints on the energy of the SD band energies and on the well-depths at low and high spins have been obtained. At the point of decay around spin 10, we suggest that the SD band is 3.3--4.3 MeV above the normal yrast line and that the well depths at spin 10 and 40 are 0.5--1.3 and 3.5--4.5 MeV, respectively.

  18. Feeding and decay of superdeformed states

    SciTech Connect

    Khoo, T.L.; Lauritsen, T.; Ahmad, I.; Carpenter, M.P.; Fernandez, P.B.; Janssens, R.V.F.; Moore, E.F.; Wolfs, F.L.H. ); Benet, Ph.; Daly, P.J. ); Beard, K.B.; Garg, U.; Ye, D. ); Drigert, M.W. )

    1992-01-01

    The mechanisms for feeding and decay of superdeformed (SD) bands are examined. Data connected with both processes in [sup 192]Hg are compared with model calculations. The calculations successfully reproduce the data, suggesting that the mechanisms for both processes are understood. Constraints on the energy of the SD band energies and on the well-depths at low and high spins have been obtained. At the point of decay around spin 10, we suggest that the SD band is 3.3--4.3 MeV above the normal yrast line and that the well depths at spin 10 and 40 are 0.5--1.3 and 3.5--4.5 MeV, respectively.

  19. Rare B Decays

    SciTech Connect

    Jackson, P.D.; /Victoria U.

    2006-02-24

    Recent results from Belle and BaBar on rare B decays involving flavor-changing neutral currents or purely leptonic final states are presented. Measurements of the CP asymmetries in B {yields} K*{gamma} and b {yields} s{gamma} are reported. Also reported are updated limits on B{sup +} {yields} K{sup +}{nu}{bar {nu}}, B{sup +} {yields} {tau}{sup +}{nu}, B{sup +} {yields} {mu}{sup +}{nu} and the recent measurement of B {yields} X{sub s}{ell}{sup +}{ell}{sup -}.

  20. Dynamic alignment and selective decay in MHD

    NASA Technical Reports Server (NTRS)

    Matthaeus, W. H.; Montgomery, D.

    1983-01-01

    Under some circumstances, incompressible magnetohydrodynamic turbulence will evolve toward a state in which the velocity fields and magnetic fields are aligned or anti-aligned. We propose a mechanism for this effect and illustrate with numerical computations. Under some other circumstances, the energy appears to decay selectively toward a minimum energy state in which the kinetic energy has disappeared. It has not been possible so far to identify a boundary in the phase space which divides the two regimes.

  1. Rare decays and CP asymmetries in charged B decays

    SciTech Connect

    Deshpande, N.G.

    1991-01-01

    The theory of loop induced rare decays and the rate asymmetry due to CP violation in charged B Decays in reviewed. After considering b {yields} s{gamma} and b {yields} se{sup +}e{sup {minus}} decays, the asymmetries for pure penguin process are estimated first. A larger asymmetry can result in those modes where a tree diagram and a penguin diagram interfere, however these estimates are necessarily model dependent. Estimates of Cabbibo suppressed penguins are also considered.

  2. Sound decay of notes from acoustic guitars

    NASA Astrophysics Data System (ADS)

    Galazen, Erika; Nordberg, Joni; Huber, Thomas M.

    2005-09-01

    The acoustic guitar produces tones by transferring energy from the strings, through the bridge to the top plate, back, and air cavity of the guitar. The vibrations are ultimately radiated into the air as sound. The air-cavity and body resonances of the guitar play an important role in both the tone and the sustain (the time it takes notes to decay) produced by the guitar. To study the relationship between resonances of the guitar and the sustain of notes, the resonance frequencies were measured using a mechanical shaker attached to the body of the guitar and laser Doppler vibrometer to measure its vibration. A string was tuned to different frequencies and plucked. The decay of the note was measured with an electromagnetic pickup that measured the vibration of the string, a vibrometer to measure vibration of the top plate, and microphones located inside and outside the guitar. As expected, when the fundamental frequency of the string was near one of the resonances of the guitar, the decay rate was faster (shorter sustain) than when the string was between resonances. The relationship between the decay rates of the different parts of the system will also be discussed.

  3. Decay of Bogoliubov excitations in one-dimensional Bose gases

    NASA Astrophysics Data System (ADS)

    Ristivojevic, Zoran; Matveev, K. A.

    2016-07-01

    We study the decay of Bogoliubov quasiparticles in one-dimensional Bose gases. Starting from the hydrodynamic Hamiltonian, we develop a microscopic theory that enables one to systematically study both the excitations and their decay. At zero temperature, the leading mechanism of decay of a quasiparticle is disintegration into three others. We find that low-energy quasiparticles (phonons) decay with the rate that scales with the seventh power of momentum, whereas the rate of decay of the high-energy quasiparticles does not depend on momentum. In addition, our approach allows us to study analytically the quasiparticle decay in the whole crossover region between the two limiting cases. When applied to integrable models, including the Lieb-Liniger model of bosons with contact repulsion, our theory confirms the absence of the decay of quasiparticle excitations. We account for two types of integrability-breaking perturbations that enable finite decay: three-body interaction between the bosons and two-body interaction of finite range.

  4. Deactivation of Ni2P/SiO2 catalyst in hydrodechlorination of chlorobenzene

    NASA Astrophysics Data System (ADS)

    Chen, Jixiang; Ci, Donghui; Yang, Qing; Li, Kelun

    2014-11-01

    The deactivation of the Ni2P/SiO2 catalyst in the hydrodechlorination of chlorobenzene was studied. To better illuminate the reasons for the deactivation, the effect of HCl on the structure and activity of Ni2P/SiO2 was investigated. For comparison, the deactivation of the Ni/SiO2 catalyst was also involved. It was found that the Ni2P particles possessed good resistance to HCl poison and to sintering, which is ascribed to the electron-deficiency of Niδ+(0 < δ < 1) site in Ni2P. Acted as the Lewis and Brönsted acid site, the Niδ+ site and the Psbnd OH group on Ni2P/SiO2 catalyzed the formation of the carbonaceous deposit that was difficultly eliminated by hydrogenation. The carbonaceous deposit covered the active sites and might also induce a decrease in the Ni2P crystallinity, subsequently leading to the Ni2P/SiO2 deactivation. Different from Ni2P/SiO2, Ni/SiO2 was mainly deactivated by the chlorine poison and the sintering of nickel crystallites.

  5. A Study of Perkins 2P1 Graduation Performance Rates at Virginia Western Community College

    ERIC Educational Resources Information Center

    Archer, J. Andrew.

    2006-01-01

    "2P1" is the Carl Perkins label for an institution's graduation performance rate. Systems receiving Perkins funds, like Virginia's 23 community colleges, are expected to meet a federally approved 2P1 target rate. For the 3-year period 1999-2001 Virginia Western Community College (VWCC) was one of seven community colleges in the VCCS (Virginia…

  6. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... § 1917.2(p)). 2 The Department of Transportation and the United States Coast Guard apply requirements related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2010-07-01 2010-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section...

  7. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... § 1917.2(p)). 2 The Department of Transportation and the United States Coast Guard apply requirements related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2014-07-01 2014-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section...

  8. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... § 1917.2(p)). 2 The Department of Transportation and the United States Coast Guard apply requirements related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2011-07-01 2011-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section...

  9. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... § 1917.2(p)). 2 The Department of Transportation and the United States Coast Guard apply requirements related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2013-07-01 2013-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section...

  10. 29 CFR 1917.22 - Hazardous cargo 2 (See § 1917.2(p)).

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... § 1917.2(p)). 2 The Department of Transportation and the United States Coast Guard apply requirements related to handling, storing and transportation of hazardous cargo (see 33 CFR part 126, 46 CFR, 49 CFR... 29 Labor 7 2012-07-01 2012-07-01 false Hazardous cargo 2 (See § 1917.2(p)). 1917.22 Section...

  11. Wood decay at sea

    NASA Astrophysics Data System (ADS)

    Charles, François; Coston-Guarini, Jennifer; Guarini, Jean-Marc; Fanfard, Sandrine

    2016-08-01

    The oceans and seas receive coarse woody debris since the Devonian, but the kinetics of wood degradation remains one of many unanswered questions about the fate of driftwood in the marine environment. A simple gravimetric experiment was carried out at a monitoring station located at the exit of a steep, forested Mediterranean watershed in the Eastern Pyrenees. The objective was to describe and quantify, with standardized logs (in shape, structure and constitution), natural degradation of wood in the sea. Results show that the mass decrease of wood logs over time can be described by a sigmoidal curve. The primary process of wood decay observed at the monitoring station was due to the arrival and installation of wood-boring species that consumed more than half of the total wood mass in six months. Surprisingly, in a region where there is little remaining wood marine infrastructure, "shipworms", i.e. xylophagous bivalves, are responsible for an important part of this wood decay. This suggests that these communities are maintained probably by a frequent supply of a large quantity of riparian wood entering the marine environment adjacent to the watershed. By exploring this direct link between terrestrial and marine ecosystems, our long term objective is to determine how these supplies of terrestrial organic carbon can sustain wood-based marine communities as it is observed in the Mediterranean Sea.

  12. Soudan nucleon decay program

    SciTech Connect

    Ayres, D.S.

    1981-01-01

    The Soudan nucleon decay program is being carried out in the Soudan iron mine in northeastern Minnesota, at a depth of 2000 m of water equivalent. A 30-ton prototype experiment, Soudan 1, has been built and is now being operated by a University of Minnesota - Argonne National Laboratory collaboration. The detector is a block of iron-loaded concrete instrumented with 3456 gas proportional tubes. It can detect nucleon decay at the 2 x 10/sup 30/ year level, and will measure cosmic-ray induced backgrounds. Soudan 1 is also obtaining data on very high energy cosmic-ray interactions. Monte-Carlo predictions of performance have been checked by calibration of a detector module in a charged-particle test beam. A proposal to build a 1000-ton experiment, Soudan 2, has been submitted to funding agencies in the USA and the UK by a Minnesota - Argonne - Oxford University collaboration. The proposed detector utilizes drift chambers with 50-cm drifts to obtain very fine-grained ionization and tracking information at low cost. This tracking-calorimeter detector has a fiducial mass of 650 tons, and could be operating in 1985. A drifting scheme utilizing 50 cm x 5 m x 1 cm planar chambers has been shown feasible, and prototypes of alternate drifting structures are also being studied. A plan to provide expandability to an eventual 5000 tons has been developed.

  13. Magnetic circular dichroism in the ion yield of polarized chromium atoms at the 2p edge

    SciTech Connect

    Pruemper, G.; Viefhaus, J.; Becker, U.; Kroeger, S.; Mueller, R.; Zimmermann, P.; Martins, M.

    2003-09-01

    The effect of magnetic dichroism in the partial and total ion yield of chromium, i.e., the absorption of polarized chromium vapor was observed in the gas phase. The measurements were performed at the 2p edge and at photon energies above the 2p edge. The structure of the dichroism at the 2p edge can be understood by including the coupling of the 2p hole with the 3d and 4s shells. Our experimental results for the dichroism at the 2p edge are similar to results of solid-state experiments. Implications for the sum rules used as a standard tool to calculate the spin and orbital momentum are discussed.

  14. Convergence of Internet and TV: The Commercial Viability of P2P Content Delivery

    NASA Astrophysics Data System (ADS)

    de Boever, Jorn

    The popularity of (illegal) P2P (peer-to-peer) file sharing has a disruptive impact on Internet traffic and business models of content providers. In addition, several studies have found an increasing demand for bandwidth consuming content, such as video, on the Internet. Although P2P systems have been put forward as a scalable and inexpensive model to deliver such content, there has been relatively little economic analysis of the potentials and obstacles of P2P systems as a legal and commercial content distribution model. Many content providers encounter uncertainties regarding the adoption or rejection of P2P networks to spread content over the Internet. The recent launch of several commercial, legal P2P content distribution platforms increases the importance of an integrated analysis of the Strengths, Weaknesses, Opportunities and Threats (SWOT).

  15. Inter-Coulombic decay (ICD) of endofullerene inner-vacancies in coherence with the Auger decay

    NASA Astrophysics Data System (ADS)

    Magrakvelidze, Maia; de, Ruma; Javani, Mohammad; Madjet, Mohamed; Manson, Steven T.; Chakraborty, Himadri

    2016-05-01

    For an endohedrally confined atom in a fullerene, an innershell vacancy created either in the atom or the fullerene can decay through the continuum of an outer electron hybridized between the systems. Such decays, which can be viewed as coherent superpositions of the single-center Auger and two-center inter-Coulombic (ICD) amplitudes, are found to govern leading decay mechanisms in endofullerenes. Resonances calculated by the method of time-dependent local density approximation (TDLDA) in the photoionization of noble gas endofullerenes show details of the underlying processes. These resonances are found to be significantly stronger than both regular ICD and Auger resonances, which make them well amenable for experimental detection. The work is supported by US NSF and DOE, Basic Energy Sciences.

  16. MUC1 oncoprotein suppresses activation of the ARF-MDM2-p53 pathway

    PubMed Central

    Raina, Deepak; Ahmad, Rehan; Chen, Dongshu; Kumar, Shailendra; Kharbanda, Surender; Kufe, Donald

    2011-01-01

    The MUC1 oncoprotein interacts with the c-Abl tyrosine kinase and blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. Mutation of the MUC1 cytoplasmic domain at Tyr-60 disrupts the MUC1-c-Abl interaction. The present results demonstrate that the MUC1(Y60F) mutant is a potent inducer of the ARF tumor suppressor. MUC1(Y60F) induces transcription of the ARF locus by a c-Abl-dependent mechanism that promotes CUL-4A-mediated nuclear export of the replication protein Cdc6. The functional significance of these findings is that MUC1(Y60F)-induced ARF expression and thereby inhibition of MDM2 results in the upregulation of p53 and the homeodomain interacting protein kinase 2 (HIPK2) serine/threonine kinase. HIPK2-mediated phosphorylation of p53 on Ser-46 was further associated with a shift from expression of the cell cycle arrest-related p21 gene to the apoptosis-related PUMA gene. We also show that the MUC1(Y60F) mutant functions as dominant negative inhibitor of tumorigenicity. These findings indicate that the oncogenic function of MUC1 is conferred by suppressing activation of the ARF-MDM2-p53 pathway. PMID:18981727

  17. Efficient Plasma Production in Low Background Neutral Pressures with the M2P2 Prototype

    NASA Technical Reports Server (NTRS)

    Ziemba, T.; Euripides, P.; Winglee, R.; Slough, J.; Giersch, L.

    2003-01-01

    Mini-Magnetospheric Plasma Propulsion (M2P2) seeks the creation of a large-scale (10 km radius) magnetic wall or bubble (i.e. a magnetosphere) by the electromagnetic inflation of a small-scale (20 cm radius) dipole magnet. The inflated magnetosphere will intercept the solar wind and thereby provide high-speed propulsion with modest power and fuel requirements due to the gain provided by the ambient medium. Magnetic field inflation is produced by the injection of plasma onto the dipole magnetic field eliminating the need for large mechanical structures and added material weight at launch. For successful inflation of the magnetic bubble a beta near unity must be achieved along the imposed dipole field. This is dependent on the plasma parameters that can be achieved with a plasma source that provide continuous operation at the desired power levels of 1 to 2 kilowatts. Over the last two years we have been developing a laboratory prototype to demonstrate the inflation of the magnetic field under space-like conditions. In this paper we will present some of the latest results from the prototype development at the University of Washington and show that the prototype can produce high ionization efficiencies while operating in near space like neutral background pressures producing electron temperatures of a few tens of electron volts. This allows for operation with propellant expenditures lower than originally estimated.

  18. Alpha decay in electron surrounding

    SciTech Connect

    Igashov, S. Yu.; Tchuvil’sky, Yu. M.

    2013-12-15

    The influence of atomic electron shells on the constant of alpha decay of heavy and mediummass nuclei was considered in detail. A method for simultaneously taking into account the change in the potential-barrier shape and the effect of reflection of a diverging Coulomb wave in the classically allowed region was developed. The ratios of decay probabilities per unit time for a bare nucleus and the respective neutral atom were found for some alpha-decaying isotopes.

  19. Review of semileptonic charm decays

    SciTech Connect

    Potter, D.M.

    1991-01-01

    The experimental status of D{sup 0} and D{sup +} semileptonic decays is reviewed and compared to model predictions. Topics covered are the form factor pole mass and decay rate for D {yields} Klv, the decay rate and form factor ratios for D {yields} K*lv, and, finally, the issue of modes other than Klv and K*lv. 4 refs., 5 tabs.

  20. Electron Excitation Cross Sections for the C II Transitions 2s(exp 2)2p P-2(exp 0) yields 2s2p(exp 2) P-4, D-2, and S-2

    NASA Technical Reports Server (NTRS)

    Smith, Steven J.; Zuo, M.; Chutjian, A.; Tayal, S. S.; Williams, I. D.

    1996-01-01

    Experimental and theoretical excitation cross sections are reported for the transitions 2s(exp 2) 2p-2(exp 0) yield 2s2p(exp 2)P-4, D-2, and S-2 in C II. The transition wavelengths (energies) are 2324 A (5.34 eV), 1335 x (9.29 eV), and 1036 A (11.97 eV), respectively. Use is made of electron energy-loss and merged beams methods. The energy range covered is from below each threshold (4 - 11 eV) to 15-24 eV. As in previous work with O II, care was taken to assess and minimize the metastable fraction in the C II beam, to account for contributions from nearby energy-loss features, and to collect the full angular range of inelastically scattered electrons. A comparison is made for each transition between experiment and new 8-state R-matrix calculations. Subject headings: atomic data ultraviolet: general

  1. Kinetics of an oxygen - iodine active medium with iodine atoms optically pumped on the 2P1/2 - 2P3/2 transition

    NASA Astrophysics Data System (ADS)

    Zagidullin, M. V.; Malyshev, M. S.; Azyazov, V. N.

    2015-08-01

    The kinetics of the processes occurring in an O2 - I2 - He - H2O gas flow in which photodissociation of molecular iodine at a wavelength close to 500 nm and excitation of atomic iodine on the 2P1/2 - 2P3/2 transition by narrow-band radiation near 1315 nm are implemented successively has been analysed. It is shown that implementation of these processes allows one to form an oxygen - iodine medium with a high degree of dissociation of molecular iodine and a relative content of singlet oxygen O2(a1Δ) exceeding 10%. Having formed a supersonic gas flow with a temperature ~100 K from this medium, one can reach a small-signal gain of about 10-2 cm-1 on the 2P1/2 - 2P3/2 transition in iodine atoms. The specific power per unit flow cross section in the oxygen - iodine laser with this active medium may reach ~100 W cm-2.

  2. Resonant Edge Magnetoplasmons and Their Decay in Graphene

    NASA Astrophysics Data System (ADS)

    Kumada, N.; Roulleau, P.; Roche, B.; Hashisaka, M.; Hibino, H.; Petković, I.; Glattli, D. C.

    2014-12-01

    We investigate resonant edge magnetoplasmons (EMPs) and their decay in graphene by high-frequency electronic measurements. From EMP resonances in disk shaped graphene, we show that the dispersion relation of EMPs is nonlinear due to interactions, giving rise to the intrinsic decay of EMP wave packets. We also identify extrinsic dissipation mechanisms due to interaction with localized states in bulk graphene from the decay time of EMP wave packets. We indicate that, owing to the linear band structure and the sharp edge potential, EMP dissipation in graphene can be lower than that in GaAs systems.

  3. Beta decay of polarized neutrons

    SciTech Connect

    Bopp, P.; Dubbers, D.; Hornig, L.; Klemt, E.; Last, J.; Schuetze, H.; Freedman, S.J.; Schaerpf, O.

    1985-01-15

    Beta decay of polarized neutrons has been studied with the superconductive spectrometer PERKEO at the Institut Laue-Langevin. The energy spectrum of the ..beta..-decay asymmetry has been measured for the first time; from the absolute value of the asymmetry we obtain a new value for the ratio of weak coupling constants g/sub A//g/sub V/, which is compared to similar data from hyperon decays. The measurement of further weak interaction parameters from neutron decay is in progress.

  4. Rare B Decays at Babar

    SciTech Connect

    Palombo, Fernando; Collaboration, for the BABAR

    2009-01-12

    The author presents some of the most recent BABAR measurements for rare B decays. These include rate asymmetries in the B decays to K{sup (*)}l{sup +}l{sup -} and K{sup +}{pi}{sup -} and branching fractions in the B decays to l{sup +}{nu}{sub l}, K{sub 1}(1270){sup +}{pi}{sup -} and K{sub 1}(1400){sup +}{pi}{sup -}. The author also reports a search for the B{sup +} decay to K{sub S}{sup 0}K{sub S}{sup 0}{pi}{sup +}.

  5. Theory and LHC phenomenology of classicalon decays

    NASA Astrophysics Data System (ADS)

    Grojean, Christophe; Gupta, Rick S.

    2012-05-01

    It has been recently proposed by Dvali et al. [1] that high energy scattering in non-renormalizable theories, like the higgsless Standard Model, can be unitarized by the formation of classical configurations called classicalons. In this work we argue that clas- sicalons should have analogs of thermodynamic properties like temperature and entropy and perform a model-independent statistical mechanical analysis of classicalon decays. We find that, in the case of massless quanta, the decay products have a Planck distribution with an effective temperature {{T}}˜ {1}/{{{r}}_{*}} , where r ∗ is the classicalon radius. These results, in particular a computation of the decay multiplicity, N ∗, allow us to make the first collider analysis of classicalization. In the model for unitarization of WW scattering by classical- ization of longitudinal Ws and Zs we get spectacular multi- W/ Z final states that decay into leptons, missing energy and a very high multiplicity (at least 10) of jets. We find that for the classicalization scale, {M_{ * }} = \\upsilon = {246} {{GeV}}({{{M}}_{ * }} = {{1TeV}}) discovery should be possible in the present 7 TeV (14 TeV) run of the LHC with about 10 fb-1 (100 fb-1) data. We also consider a model to solve the hierarchy problem, where the classicalons are configurations of the Higgs field which decay into to multi-Higgs boson final states. We find that, in this case, for M ∗ = 500 GeV ( M ∗ = 1 TeV), discovery should be possible in the top fusion process with about 10 fb-1 (100 fb-1) data at 14 TeV LHC.

  6. Solution structure of the ubiquitin-binding domain in Swa2p from Saccharomyces cerevisiae.

    PubMed

    Chim, Nicholas; Gall, Walter E; Xiao, Jing; Harris, Mark P; Graham, Todd R; Krezel, Andrzej M

    2004-03-01

    The SWA2/AUX1 gene has been proposed to encode the Saccharomyces cerevisiae ortholog of mammalian auxilin. Swa2p is required for clathrin assembly/dissassembly in vivo, thereby implicating it in intracellular protein and lipid trafficking. While investigating the 287-residue N-terminal region of Swa2p, we found a single stably folded domain between residues 140 and 180. Using binding assays and structural analysis, we established this to be a ubiquitin-associated (UBA) domain, unidentified by bioinformatics of the yeast genome. We determined the solution structure of this Swa2p domain and found a characteristic three-helix UBA fold. Comparisons of structures of known UBA folds reveal that the position of the third helix is quite variable. This helix in Swa2p UBA contains a bulkier tyrosine in place of smaller residues found in other UBAs and cannot pack as close to the second helix. The molecular surface of Swa2p UBA has a mostly negative potential, with a single hydrophobic surface patch found also in the UBA domains of human protein, HHR23A. The presence of a UBA domain implicates Swa2p in novel roles involving ubiquitin and ubiquitinated substrates. We propose that Swa2p is a multifunctional protein capable of recognizing several proteins through its protein-protein recognition domains. PMID:14997574

  7. Functional Diversification of Fungal Glutathione Transferases from the Ure2p Class

    PubMed Central

    Thuillier, Anne; Ngadin, Andrew A.; Thion, Cécile; Billard, Patrick; Jacquot, Jean-Pierre; Gelhaye, Eric; Morel, Mélanie

    2011-01-01

    The glutathione-S-transferase (GST) proteins represent an extended family involved in detoxification processes. They are divided into various classes with high diversity in various organisms. The Ure2p class is especially expanded in saprophytic fungi compared to other fungi. This class is subdivided into two subclasses named Ure2pA and Ure2pB, which have rapidly diversified among fungal phyla. We have focused our analysis on Basidiomycetes and used Phanerochaete chrysosporium as a model to correlate the sequence diversity with the functional diversity of these glutathione transferases. The results show that among the nine isoforms found in P. chrysosporium, two belonging to Ure2pA subclass are exclusively expressed at the transcriptional level in presence of polycyclic aromatic compounds. Moreover, we have highlighted differential catalytic activities and substrate specificities between Ure2pA and Ure2pB isoforms. This diversity of sequence and function suggests that fungal Ure2p sequences have evolved rapidly in response to environmental constraints. PMID:22164343

  8. Cloning, sequence analysis and radiation hybrid mapping of a mammalian KRT2p gene.

    PubMed

    Miller, A B; Lowe, J K; Ostrander, E A; Galibert, F; Murphy, K E

    2001-09-01

    We report here on the cloning, characterization and radiation hybrid mapping of the canine basic keratin gene KRT2p. The gene spans 8.3 kb, consists of nine exons and eight introns, and is characterized by the typical features of both basic keratins and keratins in general, including glycine-rich head and tail domains, which flank an alpha-helical rod domain of approximately 310 amino acids. Comparisons of sequence and structure reveal that canine KRT2p is strikingly similar to human KRT2p. Alignment of the predicted amino acid sequences for human and dog reveals greater than 80% identity. In the rod domain, the amino acid identity exceeds 90%. We note, however, that canine KRT2p encodes a protein 21 residues longer than human K2p due to the insertion of a glycine repeat motif, GG(G)X, in the head and tail domains of the canine gene. This is the first report of the nearly complete genome sequence for KRT2p of any organism. Radiation hybrid mapping of canine KRT2p to chromosome 27 of the dog is also reported. PMID:11793249

  9. Aberrant activation of the androgen receptor by NF-kappaB2/p52 in prostate cancer cells.

    PubMed

    Nadiminty, Nagalakshmi; Lou, Wei; Sun, Meng; Chen, Jun; Yue, Jiao; Kung, Hsing-Jien; Evans, Christopher P; Zhou, Qinghua; Gao, Allen C

    2010-04-15

    Prostate cancer initiation and progression are uniquely dependent on the androgen receptor (AR). Even when the cancer progresses to a castration-resistant stage, AR signaling remains active via a variety of mechanisms. In the present study, we showed that NF-kappaB/p52 can activate the AR, resulting in increased transactivation of AR-responsive genes, such as PSA and NKX3.1, in a ligand-independent manner. NF-kappaB2/p52 enhances nuclear translocation and activation of AR by interacting with its NH(2)-terminal domain and enhances the recruitment of coactivators such as p300 to the promoters of AR-dependent genes. These results were confirmed in three different prostate cancer cell lines: LAPC-4 (wild-type AR), LNCaP (mutant AR), and C4-2 (castration resistant). Transfection of p52 into LAPC-4 and LNCaP cells (which express low levels of p52) showed increased activation of the endogenous AR. Downregulation of endogenous p52 in C4-2 cells resulted in abrogation of AR constitutive activation. Comparison of the relative effects of p52 and p65 (RelA) showed that p52, but not p65, could activate the AR. Collectively, these findings, together with previous reports that the levels of NF-kappaB2/p52 are elevated in prostate cancer cells and that active NF-kappaB2/p52 promotes prostate cancer cell growth in vitro and in vivo, suggest that NF-kappaB2/p52 may play a critical role in the progression of castration-resistant prostate cancer.

  10. Decay of oscillating universes

    NASA Astrophysics Data System (ADS)

    Mithani, Audrey Todhunter

    It has been suggested by Ellis et al that the universe could be eternal in the past, without beginning. In their model, the "emergent universe'' exists forever in the past, in an "eternal'' phase before inflation begins. We will show that in general, such an "eternal'' phase is not possible, because of an instability due to quantum tunneling. One candidate model, the "simple harmonic universe'' has been shown by Graham et al to be perturbatively stable; we find that it is unstable with respect to quantum tunneling. We also investigate the stability of a distinct oscillating model in loop quantum cosmology with respect to small perturbations and to quantum collapse. We find that the model has perturbatively stable and unstable solutions, with both types of solutions occupying significant regions of the parameter space. All solutions are unstable with respect to collapse by quantum tunneling to zero size. In addition, we investigate the effect of vacuum corrections, due to the trace anomaly and the Casimir effect, on the stability of an oscillating universe with respect to decay by tunneling to the singularity. We find that these corrections do not generally stabilize an oscillating universe. Finally, we determine the decay rate of the oscillating universe. Although the wave function of the universe lacks explicit time dependence in canonical quantum cosmology, time evolution may be present implicitly through the semiclassical superspace variables, which themselves depend on time in classical dynamics. Here, we apply this approach to the simple harmonic universe, by extending the model to include a massless, minimally coupled scalar field φ which has little effect on the dynamics but can play the role of a "clock''.

  11. Double photoionization of helium from the 1s2p {}^{3}{\\rm{P}} excited state

    NASA Astrophysics Data System (ADS)

    Li, Y.; Pindzola, M. S.; Colgan, J.

    2016-10-01

    Time-dependent close-coupling (TDCC) calculations are carried out for the double photoionization of Helium in the 1{{s}}2{{p}}{}3{{P}} excited state. TDCC {l}1{l}2L results are presented for the total and energy differential cross sections for the 1{{s}}2{{p}}{}3{{P}} term. TDCC {l}1{j}1{l}2{j}2J results are presented for the total and energy differential cross sections for the 1{{s}}2{{p}}{}3{{{P}}}{0,1,2} levels. Differences found between the level resolved double photoionization cross sections are due to varying degrees of continuum correlation found in the outgoing two electrons.

  12. Status of rare decay experiments

    SciTech Connect

    Littenberg, L.S.

    1984-01-01

    Some results are given for rare muon decay experiments currently running. Also, plans are discussed for rare kaon decay experiments. Some of the events sought come from processes which violate lepton flavor conservation. Several apparatuses used in the search are described. 35 references. (LEW)

  13. Particle decay in inflationary cosmology

    SciTech Connect

    Boyanovsky, D.; Vega, H.J. de

    2004-09-15

    We investigate the relaxation and decay of a particle during inflation by implementing the dynamical renormalization group. This investigation allows us to give a meaningful definition for the decay rate in an expanding universe. As a prelude to a more general scenario, the method is applied here to study the decay of a particle in de Sitter inflation via a trilinear coupling to massless conformally coupled particles, both for wavelengths much larger and much smaller than the Hubble radius. For superhorizon modes we find that the decay is of the form {eta}{sup {gamma}{sub 1}} with {eta} being conformal time and we give an explicit expression for {gamma}{sub 1} to leading order in the coupling which has a noteworthy interpretation in terms of the Hawking temperature of de Sitter space-time. We show that if the mass M of the decaying field is <decay rate during inflation is enhanced over the Minkowski space-time result by a factor 2H/{pi}M. For wavelengths much smaller than the Hubble radius we find that the decay law is e with C({eta}) the scale factor and {alpha} determined by the strength of the trilinear coupling. In all cases we find a substantial enhancement in the decay law as compared to Minkowski space-time. These results suggest potential implications for the spectrum of scalar density fluctuations as well as non-Gaussianities.

  14. Top decays in extended models

    SciTech Connect

    Gaitan, R.; Miranda, O. G.; Cabral-Rosetti, L. G.

    2009-04-20

    Top quark decays are interesting as a mean to test the Standard Model (SM) predictions. The Cabbibo-Kobayashi-Maskawa (CKM)-suppressed process t{yields}cWW, and the rare decays t{yields}cZ, t{yields}H{sup 0}+c, and t{yields}c{gamma} an excellent window to probe the predictions of theories beyond the SM. We evaluate the flavor changing neutral currents (FCNC) decay t{yields}H{sup 0}+c in the context of Alternative Left-Right symmetric Models (ALRM) with extra isosinglet heavy fermions; the FCNC decays may place at tree level and are only supressed by the mixing between ordinary top and charm quarks. We also comment on the decay process t{yields}c+{gamma}, which involves radiative corrections.

  15. Spectral decomposition of phosphorescence decays.

    PubMed

    Fuhrmann, N; Brübach, J; Dreizler, A

    2013-11-01

    In phosphor thermometry, the fitting of decay curves is a key task in the robust and precise determination of temperatures. These decays are generally assumed to be mono-exponential in certain temporal boundaries, where fitting is performed. The present study suggests a multi-exponential method to determine the spectral distribution in terms of decay times in order to analyze phosphorescence decays and thereby complement the mono-exponential analysis. Therefore, two methods of choice are compared and verified using simulated data in the presence of noise. Addtionally, this spectral decomposition is applied to the thermographic phosphor Mg4FGeO6 : Mn and reveals changes in the exponential distributions of decay times upon a change of the excitation laser energy.

  16. Fine structure of cluster decays

    SciTech Connect

    Dumitrescu, O.

    1994-03-01

    Within the one level {ital R}-matrix approach, expressions are derived for the hindrance factors of cluster radioactive decays in which {ital y} {ital the} {ital shell} {ital model} {ital with} {ital effective} {ital residual} {ital interactions} [{ital e}.{ital g}.,{ital thelar} in the Michigan State University version for nearly spherical nuclei, or the enlarged superfluid model (ESM) recently proposed for deformed nuclei]. The exterior wave functions are calculated from a cluster-nucleus double-folding model potential obtained with the M3Y interaction. As examples of the cluster decay fine structure we analyzed the particular cases of {alpha} decay of {sup 241}Am and {sup 243}Cm, {sup 14}C decay of {sup 223}Ra, and {sup 34}Si decay of {sup 243}Cm. Good agreement with the experimental data is obtained.

  17. Absolute cross sections for near-threshold electron-impact excitation of the 2s 2S-->2p 2P transition in C3+

    NASA Astrophysics Data System (ADS)

    Bannister, M. E.; Chung, Y.-S.; Djurić, N.; Wallbank, B.; Woitke, O.; Zhou, S.; Dunn, G. H.; Smith, A. C.

    1998-01-01

    Absolute total cross sections for electron-impact excitation of the 2s 2S-->2p 2P transition in C3+ were measured from 7.35 eV to 8.45 eV using the merged electron-ion-beams energy-loss technique. The results settle the discrepancy between two previous experiments using the crossed-beams fluorescence method, being in very good agreement with the older results [P. O. Taylor, D. Gregory, G. H. Dunn, R. A. Phaneuf, and D. H. Crandall, Phys. Rev. Lett. 39, 1256 (1977)] but less so with the more recent ones [D. W. Savin, L. D. Gardner, D. B. Reisenfeld, A. R. Young, and J. L. Kohl, Phys. Rev. A 51, 2162 (1995)]. The present measurements are also in good agreement with unitarized Coulomb-Born and close-coupling calculations.

  18. The Effect of Etching Time on Rectifying Characteristic in SnO2/p-Si and SnO2/p-PoSi Heterojunction Schottky Diodes

    NASA Astrophysics Data System (ADS)

    Biaram, Alireza; Eshghi, Hosein

    2013-03-01

    We have fabricated SnO2/p-Si and SnO2/p-PoSi heterojunction diodes by spray pyrolysis method. To prepare porous Si substrates, the etching time was varied from 10 to 20 and 30 mins. In these samples, the SEM micrographs showed a distributed pore areas surrounded by columnar walls with various height. The data analysis of the rectified I-V characteristic, using thermionic emission Schottky diode theory, showed that although the barrier height is about 0.5-0.6 eV in all samples other two important diode parameters, i.e. the ideality factor n and the series resistance rs, are strongly etching time-dependant and are increased with increasing the etching time.

  19. 2. P.S. Rittermann, Photographer February 1995 BUILDING 990, WEST SIDE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. P.S. Rittermann, Photographer February 1995 BUILDING 990, WEST SIDE. - Presidio of San Francisco, Flammable Storage Building Submarine Mine Depot, Fort Point vicinity, Long Avenue, San Francisco, San Francisco County, CA

  20. Amyloid-like properties of Saccharomyces cerevisiae cell wall glucantransferase Bgl2p

    PubMed Central

    Plotnikova, Tatyana A; Gorkovskii, Anton A; Selyakh, Irina O; Galzitskaya, Oxana V; Bezsonov, Evgeniy E; Gellissen, Gerd; Kulaev, Igor S

    2008-01-01

    Glucantransferase Bgl2p is a major conserved cell wall constituent described for a wide range of yeast species. In the baker's yeast Saccharomyces cerevisiae it is the only non-covalently bound cell wall protein that cannot be released from cell walls by sequential SDS and trypsin treatment. It contains seven amyloidogenic determinants. Circular dichroism analysis and fluorescence spectroscopy with thioflavin T indicate the presence of β-sheet structures in Bgl2p isolates. Bgl2p forms fibrils, a process that is enforced in the presence of other cell wall components. Thus the data obtained is the first evidence for amyloid-like properties of yeast cell wall protein—glucantransferase Bgl2p. PMID:19098439

  1. 49 CFR 178.33 - Specification 2P; inner nonrefillable metal receptacles.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 3 2013-10-01 2013-10-01 false Specification 2P; inner nonrefillable metal receptacles. 178.33 Section 178.33 Transportation Other Regulations Relating to Transportation (Continued... nonrefillable metal receptacles....

  2. 49 CFR 178.33 - Specification 2P; inner nonrefillable metal receptacles.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Specification 2P; inner nonrefillable metal receptacles. 178.33 Section 178.33 Transportation Other Regulations Relating to Transportation PIPELINE AND... nonrefillable metal receptacles....

  3. 49 CFR 178.33 - Specification 2P; inner nonrefillable metal receptacles.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 3 2012-10-01 2012-10-01 false Specification 2P; inner nonrefillable metal receptacles. 178.33 Section 178.33 Transportation Other Regulations Relating to Transportation (Continued... nonrefillable metal receptacles....

  4. 49 CFR 178.33 - Specification 2P; inner nonrefillable metal receptacles.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 3 2014-10-01 2014-10-01 false Specification 2P; inner nonrefillable metal receptacles. 178.33 Section 178.33 Transportation Other Regulations Relating to Transportation (Continued... nonrefillable metal receptacles....

  5. Molecular Aspects of Structure, Gating, and Physiology of pH-Sensitive Background K2P and Kir K+-Transport Channels

    PubMed Central

    Sepúlveda, Francisco V.; Pablo Cid, L.; Teulon, Jacques; Niemeyer, María Isabel

    2015-01-01

    K+ channels fulfill roles spanning from the control of excitability to the regulation of transepithelial transport. Here we review two groups of K+ channels, pH-regulated K2P channels and the transport group of Kir channels. After considering advances in the molecular aspects of their gating based on structural and functional studies, we examine their participation in certain chosen physiological and pathophysiological scenarios. Crystal structures of K2P and Kir channels reveal rather unique features with important consequences for the gating mechanisms. Important tasks of these channels are discussed in kidney physiology and disease, K+ homeostasis in the brain by Kir channel-equipped glia, and central functions in the hearing mechanism in the inner ear and in acid secretion by parietal cells in the stomach. K2P channels fulfill a crucial part in central chemoreception probably by virtue of their pH sensitivity and are central to adrenal secretion of aldosterone. Finally, some unorthodox behaviors of the selectivity filters of K2P channels might explain their normal and pathological functions. Although a great deal has been learned about structure, molecular details of gating, and physiological functions of K2P and Kir K+-transport channels, this has been only scratching at the surface. More molecular and animal studies are clearly needed to deepen our knowledge. PMID:25540142

  6. Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.

    PubMed

    Sepúlveda, Francisco V; Pablo Cid, L; Teulon, Jacques; Niemeyer, María Isabel

    2015-01-01

    K(+) channels fulfill roles spanning from the control of excitability to the regulation of transepithelial transport. Here we review two groups of K(+) channels, pH-regulated K2P channels and the transport group of Kir channels. After considering advances in the molecular aspects of their gating based on structural and functional studies, we examine their participation in certain chosen physiological and pathophysiological scenarios. Crystal structures of K2P and Kir channels reveal rather unique features with important consequences for the gating mechanisms. Important tasks of these channels are discussed in kidney physiology and disease, K(+) homeostasis in the brain by Kir channel-equipped glia, and central functions in the hearing mechanism in the inner ear and in acid secretion by parietal cells in the stomach. K2P channels fulfill a crucial part in central chemoreception probably by virtue of their pH sensitivity and are central to adrenal secretion of aldosterone. Finally, some unorthodox behaviors of the selectivity filters of K2P channels might explain their normal and pathological functions. Although a great deal has been learned about structure, molecular details of gating, and physiological functions of K2P and Kir K(+)-transport channels, this has been only scratching at the surface. More molecular and animal studies are clearly needed to deepen our knowledge.

  7. Beam-foil spectroscopical study of the 1s2s2p and 1s2p 2 quartet levels of Mg 9+ and Al 10+

    NASA Astrophysics Data System (ADS)

    Hellmann, H.; Träbert, E.

    1985-07-01

    Results of recent measurements of the fine structure and multiplet separation of the lowest quartet terms of doubly excited three-electron ions of Mg and Al are compared with other experiments and with theory. Preliminary results of lifetime measurements of 1s2p 24P 1/2.3/2 levels are presented. They confirm the recent calculation by Chen. Crasemann and Mark and contradict older calculations by Tunnell and Bhalla.

  8. Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels.

    PubMed

    Bockenhauer, D; Nimmakayalu, M A; Ward, D C; Goldstein, S A; Gallagher, P G

    2000-12-31

    A 2 P domain potassium channel expressed in eye, lung, and stomach, Kcnk8, has recently been identified. To initiate further biochemical and genetic studies of this channel, we assembled the murine Kcnk8 cDNA sequence, characterized the genomic structure of the Kcnk8 gene, determined its chromosomal localization, and analyzed its activity in a Xenopus laevis oocyte expression system. The composite cDNA has an open reading frame of 1029 bp and encodes a protein of 343 amino acids with a predicted molecular mass of 36 kDa. Structure analyses predict 2 P domains and four potential transmembrane helices with a potential single EF-hand motif and four potential SH3-binding motifs in the COOH-terminus. Cloning of the Kcnk8 chromosomal gene revealed that it is composed of three exons distributed over 4 kb of genomic DNA. Genome database searching revealed that one of the intron/exon boundaries identified in Kcnk8 is present in other mammalian 2 P domain potassium channels genes and many C. elegans 2P domain potassium channel genes, revealing evolutionary conservation of gene structure. Using fluorescence in situ hybridization, the murine Kcnk8 gene was mapped to chromosome 19, 2B, the locus of the murine dancer phenotype, and syntenic to 11q11-11q13, the location of the human homologue. No significant currents were generated in a Xenopus laevis oocyte expression system using the composite Kcnk8 cDNA sequence, suggesting, like many potassium channels, additional channel subunits, modulator substances, or cellular chaperones are required for channel function.

  9. Kinetics of the Reactions of Cl((sup 2)P(sub J)) and Br((sup 2)P(sub 3/2)) with O3

    NASA Technical Reports Server (NTRS)

    Nicovich, J. M.; Kreutter, K. D.; Wine, P. H.

    1997-01-01

    A laser flash photolysis-resonance fluorescence technique has been employed to study the kinetics of the important stratospheric reactions Cl((sup 2)P(sub J)) + O3 yields ClO + O2 and Br((sup 2)P(sub 3/2)) + O3 yields BrO + O2 as a function of temperature. The temperature dependence observed for the Cl((sup 2)P(sub J)) + O3 reaction is nonArrhenius, but can be adequately described by the following two Arrhenius expressions (units are cu cm/(molecule.s), errors are 2 sigma and represent precision only): k(sub 1)(T) = (1.19 +/- 0.21) x 10(exp -11) exp[(-33 +/- 37)/T] for T = 189-269 K and k(sub 1)(T) = (2.49 +/- 0.38) x 10(exp -11) exp[(-233 +/- 46)/T] for 269-385 K. At temperatures below 230 K, the rate coefficients determined in this study are faster than any reported previously. Incorporation of our values for k(sub 1)(T) into stratospheric models would increase calculated ClO levels and decrease calculated HCI levels; hence the calculated efficiency of ClO catalyzed ozone destruction would increase. The temperature dependence observed for the Br((sup 2)P(sub 3/2)) + O3 reaction is adequately described by the following Arrhenius expression (units are cu cm/(molecule.s), errors are 2 sigma and represent precision only): k(sub 2)(T) = (1.50 +/- 0.16) x 10(exp -11)exp[(-775 +/- 30)/T for 195-392 K. While not in quantitative agreement with Arrhenius parameters reported in most previous studies, our results almost exactly reproduce the average of all earlier studies and therefore will not affect the choice of k(sub 2)(T) for use in modeling stratospheric BrO2 chemistry.

  10. Novel features of the XRN-family in Arabidopsis: Evidence that AtXRN4, one of several orthologs of nuclear Xrn2p/Rat1p, functions in the cytoplasm

    PubMed Central

    Kastenmayer, J. P.; Green, P. J.

    2000-01-01

    The 5′-3′ exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalyzing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus. Much less is known about the XRN-like proteins of multicellular eukaryotes; however, differences in their activities could explain differences in mRNA degradation between multicellular and unicellular eukaryotes. One such difference is the lack in plants and animals of mRNA decay intermediates like those generated in yeast when Xrn1p is blocked by poly(G) tracts that are inserted within mRNAs. We investigated the XRN-family in Arabidopsis thaliana and found it to have several novel features. First, the Arabidopsis genome contains three XRN-like genes (AtXRNs) that are structurally similar to Xrn2p/Rat1p, a characteristic unique to plants. Furthermore, our experimental results and sequence database searches indicate that Xrn1p orthologs may be absent from higher plants. Second, the lack of poly(G) mRNA decay intermediates in plants cannot be explained by the activity of the AtXRNs, because they are blocked by poly(G) tracts. Finally, complementation of yeast mutants and localization studies indicate that two of the AtXRNs likely function in the nucleus, whereas the third acts in the cytoplasm. Thus, the XRN-family in plants is more complex than in other eukaryotes, and, if an XRN-like enzyme plays a role in mRNA decay in plants, the likely participant is a cytoplasmic Xrn2p/Rat1p ortholog, rather than an Xrn1p ortholog. PMID:11106401

  11. Novel features of the XRN-family in Arabidopsis: evidence that AtXRN4, one of several orthologs of nuclear Xrn2p/Rat1p, functions in the cytoplasm.

    PubMed

    Kastenmayer, J P; Green, P J

    2000-12-01

    The 5'-3' exoribonucleases Xrn1p and Xrn2p/Rat1p function in the degradation and processing of several classes of RNA in Saccharomyces cerevisiae. Xrn1p is the main enzyme catalyzing cytoplasmic mRNA degradation in multiple decay pathways, whereas Xrn2p/Rat1p functions in the processing of rRNAs and small nucleolar RNAs (snoRNAs) in the nucleus. Much less is known about the XRN-like proteins of multicellular eukaryotes; however, differences in their activities could explain differences in mRNA degradation between multicellular and unicellular eukaryotes. One such difference is the lack in plants and animals of mRNA decay intermediates like those generated in yeast when Xrn1p is blocked by poly(G) tracts that are inserted within mRNAs. We investigated the XRN-family in Arabidopsis thaliana and found it to have several novel features. First, the Arabidopsis genome contains three XRN-like genes (AtXRNs) that are structurally similar to Xrn2p/Rat1p, a characteristic unique to plants. Furthermore, our experimental results and sequence database searches indicate that Xrn1p orthologs may be absent from higher plants. Second, the lack of poly(G) mRNA decay intermediates in plants cannot be explained by the activity of the AtXRNs, because they are blocked by poly(G) tracts. Finally, complementation of yeast mutants and localization studies indicate that two of the AtXRNs likely function in the nucleus, whereas the third acts in the cytoplasm. Thus, the XRN-family in plants is more complex than in other eukaryotes, and, if an XRN-like enzyme plays a role in mRNA decay in plants, the likely participant is a cytoplasmic Xrn2p/Rat1p ortholog, rather than an Xrn1p ortholog. PMID:11106401

  12. Direct and indirect searches for anomalous beta decay

    NASA Astrophysics Data System (ADS)

    Nistor, Jonathan M.

    We present a treatment of time-varying nuclear transition rates intended to guide future experimental searches, focusing primarily on the concept of "self-induce decay.'' This investigation stems from a series of recent reports that suggest that the decay rates of several isotopes may have been influenced by solar activity (perhaps by solar neutrinos). A mechanism in which (anti)neutrinos can influence the decay process suggests that a sample of decaying nuclei emitting neutrinos could affect its own rate of decay. Past experiments have searched for this "self-induced decay" (SID) effect by measuring deviations from the expected decay rate for highly active samples of varying geometries. Here, we further develop a SID formalism which takes into account the activation process. In the course of the treatment, the observation is made that the SID behavior closely resembles the behavior of rate-related losses due to dead-time, and hence that standard dead-time corrections can result in the removal of possible SID-related behavior. Additionally, we discuss a long-running dark matter (DM) experiment which observes an annual signal predicted by standard DM models. Here, we consider the possibility that the annual signal seen by the DAMA collaboration, and interpreted by them as evidence for dark matter, may in fact be due to the radioactive contaminant 40K, which is known to be present in their detector. We also consider the possibility that part of the DAMA signal may arise from relic big-bang neutrinos.

  13. A study of a sector spectrophotometer and auroral O+(2P-2D) emissions

    NASA Technical Reports Server (NTRS)

    Swenson, G. R.

    1976-01-01

    The metastable O+(2P-2D) auroral emission was investigated. The neighboring OH contaminants and low intensity levels of the emission itself necessitated the evolution of an instrument capable of separating the emission from the contaminants and having a high sensitivity in the wavelength region of interest. A new type of scanning photometer was developed and its properties are discussed. The theoretical aspects of auroral electron interaction with atomic oxygen and the resultant O+(2P-2D) emissions were examined in conjunction with N2(+)1NEG emissions. Ground based measurements of O+(2P-2D) auroral emission intensities were made using the spatial scanning photometer (sector spectrophotometer). Simultaneous measurements of N2(+)1NEG sub 1,0 emission intensity were made in the same field of view using a tilting photometer. Time histories of the ratio of these two emissions made in the magnetic zenith during auroral breakup periods are given. Theories of I sub 7319/I sub 4278 of previous investigators were presented. A rocket measurement of N2(+)1NEG sub 0,0 and O+(2P-2D) emission in aurora was examined in detail and was found to agree with the ground based measurements. Theoretical examination resulted in the deduction of the electron impact efficiency generating O+(2P) and also suggests a large source of O+(2P) at low altitude. A possible source is charge exchange of N+(1S) with OI(3P).

  14. Measurement of the 2 sup 2 S sub 1/2 -2 sup 2 P sub 3/2 fine structure interval in muonium

    SciTech Connect

    Kettell, S.H.

    1990-08-01

    The (2{sup 2}S{sub 1/2} {minus} 2{sup 2}P{sub 3/2}) fine structure transition in muonium has been observed for the first time. The measured value is 9895 {sub {minus}30}{sup {plus}35}MHz. This measurement, when included with the theoretical value for the 2{sup 2}P{sub 1/2} {minus} 2{sup 2}P{sub 3/2} fine structure interval, gives a value for the Lamb shift (2{sup 2}S{sub 1/2} {minus} 2{sup 2}P{sub 1/2}) independent of previous direct measurements. From the theoretical value for the fine structure interval, 10921.833(3) MHz, the value for the Lamb shift determined from this experiment is 1027{sub {minus}35}{sup {plus}30} MHz and is in agreement with the prediction of quantum electrodynamics (QED) of 1047.5(3) MHz. Previous experimental values for the Lamb shift (2{sup 2}S{sub 1/2} {minus}2{sup 2}P{sub 1/2}) in muonium are 1070{sub {minus}15}{sup {plus} 12} MHz and 1042{sub {minus}23}{sup {plus}21} MHz. Combining this result with these previous results gives a new experimental value of 1058{sub {minus}12}{sup {plus}10} for the Lamb shift in muonium. Muonium, the bound state of two structureless leptons ({mu}{sup +}e{sup {minus}}), is an ideal system for testing bound state QED because of the lack of hadronic structure as exists in the hydrogen system. The measurement makes use of the techniques of atomic beam microwave spectroscopy. Muonium atoms ({mu}{sup +}e{sup {minus}}) in the 2S states are produced by the beam-foil technique at the Clinton P. Anderson Meson Physics Facility with a low momentum, sub-surface muon beam. A variable frequency microwave field is applied to drive the atoms from the 2S to the 2P states, with the subsequent observation of the Lyman alpha photon from the decay of the 2P state to the 1S ground state. The frequency is varied from 9.0--11.0 GHz, driving the F = 0 {yields} F = 1, F = 1, F = 1 and F = 1 {yields} F = 2 transitions.

  15. Aberrant splicing of the DMP1-ARF-MDM2-p53 pathway in cancer.

    PubMed

    Inoue, Kazushi; Fry, Elizabeth A

    2016-07-01

    Alternative splicing (AS) of mRNA precursors is a ubiquitous mechanism for generating numerous transcripts with different activities from one genomic locus in mammalian cells. The gene products from a single locus can thus have similar, dominant-negative or even opposing functions. Aberrant AS has been found in cancer to express proteins that promote cell growth, local invasion and metastasis. This review will focus on the aberrant splicing of tumor suppressor/oncogenes that belong to the DMP1-ARF-MDM2-p53 pathway. Our recent study shows that the DMP1 locus generates both tumor-suppressive DMP1α (p53-dependent) and oncogenic DMP1β (p53-independent) splice variants, and the DMP1β/α ratio increases with neoplastic transformation of breast epithelial cells. This process is associated with high DMP1β protein expression and shorter survival of breast cancer (BC) patients. Accumulating pieces of evidence show that ARF is frequently inactivated by aberrant splicing in human cancers, demonstrating its involvement in human malignancies. Splice variants from the MDM2 locus promote cell growth in culture and accelerate tumorigenesis in vivo. Human cancers expressing these splice variants are associated with advanced stage/metastasis, and thus have negative clinical impacts. Although they lack most of the p53-binding domain, their activities are mostly dependent on p53 since they bind to wild-type MDM2. The p53 locus produces splice isoforms that have either favorable (β/γ at the C-terminus) or negative impact (Δ40, Δ133 at the N-terminus) on patients' survival. As the oncogenic AS products from these loci are expressed only in cancer cells, they may eventually become targets for molecular therapies.

  16. Primordial nucleosynthesis with decaying particles. I - Entropy-producing decays. II - Inert decays

    NASA Technical Reports Server (NTRS)

    Scherrer, Robert J.; Turner, Michael S.

    1988-01-01

    The effect of a nonrelativistic particle X, which decays out of equilibrium, on primordial nucleosynthesis is investigated, including both the energy density of the X particle and the electromagnetic entropy production from its decay. The results are parametrized in terms of the X particle lifetime and the density parameter rm(X), where m(X) is the X particle mass and r is the ratio of X number density to photon number density prior to nucleosynthesis. The results rule out particle lifetimes greater than 1-10 s for large values of rm(X). The question of a decaying particle which produces no electromagnetic entropy in the course of its decay is addressed, and particles which produce both entropy and an inert component in their decay are discussed.

  17. Hybrid structure of X(3872) and its radiative decays

    NASA Astrophysics Data System (ADS)

    Takizawa, Makoto; Shimizu, Kiyotaka; Takeuchi, Sachiko

    2014-09-01

    We study the radiative decays of the X (3872) using a charmonium-two-meson hybrid model with the two-meson states consisting of the D0 D *0 , D+D*- , J / Φρ , and J / Φω . We can reproduce the observed mass of the X(3872) in this framework. The obtained structure of the X (3872) explains many of the observed properties, such as the isospin symmetry breaking, the production rate in the p p collision, a lack of the existence of the χc 1 (2 P) peak predicted by the quark model and the absence of the charged partner of the X (3872) . We shall report the results of the X (3872) --> J / Φ γ and X (3872) -->Φ' γ decay rates in our approach.

  18. 2P/Encke, the Taurid complex NEOs and the Maribo and Sutter's Mill meteorites

    NASA Astrophysics Data System (ADS)

    Tubiana, C.; Snodgrass, C.; Michelsen, R.; Haack, H.; Böhnhardt, H.; Fitzsimmons, A.; Williams, I. P.

    2015-12-01

    Aims: 2P/Encke is a short period comet that was discovered in 1786 and has been extensively observed and studied for more than 200 years. The Taurid meteoroid stream has long been linked with 2P/Encke owing to a good match of their orbital elements, even though the comet's activity is not strong enough to explain the number of observed meteors. Various small near-Earth objects (NEOs) have been discovered with orbits that can be linked to 2P/Encke and the Taurid meteoroid stream. Maribo and Sutter's Mill are CM type carbonaceous chondrite that fell in Denmark on January 17, 2009 and April 22, 2012, respectively. Their pre-atmospheric orbits place them in the middle of the Taurid meteoroid stream, which raises the intriguing possibility that comet 2P/Encke could be the parent body of CM chondrites. Methods: To investigate whether a relationship between comet 2P/Encke, the Taurid complex associated NEOs, and CM chondrites exists, we performed photometric and spectroscopic studies of these objects in the visible wavelength range. We observed 2P/Encke and 10 NEOs on August 2, 2011 with the FORS instrument at the 8.2 m Very Large Telescope on Cerro Paranal (Chile). Results: Images in the R filter, used to investigate the possible presence of cometary activity around the nucleus of 2P/Encke and the NEOs, show that no resolved coma is present. None of the FORS spectra show the 700 nm absorption feature due to hydrated minerals that is seen in the CM chondrite meteorites. All objects show featureless spectra with moderate reddening slopes at λ< 800 nm. Apart for 2003 QC10 and 1999 VT25, which show a flatter spectrum, the spectral slope of the observed NEOs is compatible with that of 2P/Encke. However, most of the NEOs show evidence of a silicate absorption in lower S/N data at λ> 800 nm, which is not seen in 2P/Encke, which suggests that they are not related. Conclusions: Despite similar orbits, we find no spectroscopic evidence for a link between 2P/Encke, the Taurid

  19. Evolution of interatomic Coulombic decay in the time domain.

    PubMed

    Trinter, F; Williams, J B; Weller, M; Waitz, M; Pitzer, M; Voigtsberger, J; Schober, C; Kastirke, G; Müller, C; Goihl, C; Burzynski, P; Wiegandt, F; Bauer, T; Wallauer, R; Sann, H; Kalinin, A; Schmidt, L Ph H; Schöffler, M; Sisourat, N; Jahnke, T

    2013-08-30

    During the past 15 years a novel decay mechanism of excited atoms has been discovered and investigated. This so-called interatomic Coulombic decay (ICD) involves the chemical environment of the electronically excited atom: the excitation energy is transferred (in many cases over long distances) to a neighbor of the initially excited particle usually ionizing that neighbor. It turned out that ICD is a very common decay route in nature as it occurs across van der Waals and hydrogen bonds. The time evolution of ICD is predicted to be highly complex, as its efficiency strongly depends on the distance of the atoms involved and this distance typically changes during the decay. Here we present the first direct measurement of the temporal evolution of ICD using a novel experimental approach.

  20. Covariant calculation of strange decays of baryon resonances

    SciTech Connect

    Sengl, B.; Melde, T.; Plessas, W.

    2007-09-01

    We present results for kaon decay widths of baryon resonances from a relativistic study with constituent quark models. The calculations are done in the point form of Poincare-invariant quantum mechanics with a spectator-model decay operator. We obtain covariant predictions of the Goldstone-boson-exchange and a variant of the one-gluon-exchange constituent quark models for all kaon decay widths of established baryon resonances. They are generally characterized by underestimating the available experimental data. In particular, the widths of kaon decays with decreasing strangeness in the baryon turn out to be extremely small. We also consider the nonrelativistic limit, leading to the familiar elementary emission model, and demonstrate the importance of relativistic effects. It is found that the nonrelativistic approach evidently misses sensible influences from Lorentz boosts and some essential spin-coupling terms.

  1. Theory of cluster radioactive decay and of cluster formation in nuclei

    SciTech Connect

    Malik, S.S.; Gupta, R.K.

    1989-05-01

    A new model is proposed for the mechanism of cluster formation and then penetration of the confining nuclear interaction barrier in radioactive nuclei. The cluster formation is treated as a quantum-mechanical fragmentation process and the WKB penetrability is found analytically. Applications of the model are made to /sup 14/C decay of /sup 222-224/Ra and /sup 24/Ne decay of /sup 232/U. The branching ratio for /sup 14/C decay of /sup 232/U is also calculated and is found to be incredibly small as compared to that for its /sup 24/Ne decay.

  2. Discovery of a nonyrast K{sup {pi}}=8{sup +} isomer in {sup 162}Dy, and the influence of competing K-mixing mechanisms on its highly forbidden decay

    SciTech Connect

    Swan, T. P. D.; Walker, P. M.; Podolyak, Zs.; Reed, M. W.; Dracoulis, G. D.; Lane, G. J.; Kibed, T.; Smith, M. L.

    2011-03-15

    The {sup 160}Gd({sup 9}Be,{alpha}3n){sup 162}Dy reaction has been used to study high-spin states in {sup 162}Dy. Pulsed beam conditions were utilized for enhanced isomer sensitivity. An isomer at 2188.1(3) keV with a half-life of 8.3(3) {mu}s has been discovered and assigned K{sup {pi}}= 8{sup +} with a two-quasineutron configuration. Among 11 {gamma}-ray decay branches, an E2, {Delta}K=8 transition to the ground-state band was observed with a reduced hindrance of f{sub {nu}}=35, agreeing well with systematics correlating f{sub {nu}} with the product of the valence neutron and proton numbers (N{sub p}N{sub n}) over an extended N,Z range. Small deviations from N{sub p}N{sub n} dependence are analyzed for a range of two-quasiparticle isomer decays and interpreted as arising from a weak dependence on the isomer excitation energy relative to the yrast line.

  3. Optimizing VANDLE for Decay Spectroscopy

    NASA Astrophysics Data System (ADS)

    Brewer, N. T.; Taylor, S. Z.; Grzywacz, R.; Madurga, M.; Paulauskas, S. V.; Cizewski, J. A.; Peters, W. A.; Vandle Collaboration

    2013-10-01

    Understanding the decay properties of neutron rich isotopes has well established importance to the path of the r-process and to the total decay heat for reactor physics. Specifically, the half-life, branching ratio and spectra for β-n decay is of particular interest. With that in mind, we have continued attempts to improve upon the Versatile Array of Neutron Detectors at Low Energy (VANDLE) in terms of efficiency and TOF resolution through the use of new and larger scintillators. Details of the new implementation, design and characterization of the array will be shown and compared to previous results.

  4. EuCo2P2 : A model molecular-field helical Heisenberg antiferromagnet

    NASA Astrophysics Data System (ADS)

    Sangeetha, N. S.; Cuervo-Reyes, Eduardo; Pandey, Abhishek; Johnston, D. C.

    2016-07-01

    The metallic compound EuCo2P2 with the body-centered tetragonal ThCr2Si2 structure containing Eu spins-7/2 was previously shown from single-crystal neutron diffraction measurements to exhibit a helical antiferromagnetic (AFM) structure below TN=66.5 K with the helix axis along the c axis and with the ordered moments aligned within the a b plane. Here we report crystallography, electrical resistivity, heat capacity, magnetization, and magnetic susceptibility measurements on single crystals of this compound. We demonstrate that EuCo2P2 is a model molecular-field helical Heisenberg antiferromagnet from comparisons of the anisotropic magnetic susceptibility χ , high-field magnetization, and magnetic heat capacity of EuCo2P2 single crystals at temperature T ≤TN with the predictions of our recent formulation of molecular-field theory. Values of the Heisenberg exchange interactions between the Eu spins are derived from the data. The low-T magnetic heat capacity ˜T3 arising from spin-wave excitations with no anisotropy gap is calculated and found to be comparable to the lattice heat capacity. The density of states at the Fermi energy of EuCo2P2 and the related compound BaCo2P2 are found from the heat capacity data to be large, 10 and 16 states/eV per formula unit for EuCo2P2 and BaCo2P2 , respectively. These values are enhanced by a factor of ˜2.5 above those found from DFT electronic structure calculations for the two compounds. The calculations also find ferromagnetic Eu-Eu exchange interactions within the a b plane and AFM interactions between Eu spins in nearest- and next-nearest planes, in agreement with the MFT analysis of χa b(T ≤TN) .

  5. EuCo2P2: A Model Molecular-Field Helical Heisenberg Antiferromagnet

    DOE PAGES

    Sangeetha, N. S.; Cuervo-Reyes, Eduardo; Pandey, Abhishek; Johnston, D. C.

    2016-07-19

    The metallic compound EuCo2P2 with the body-centered tetragonal ThCr2Si2 structure containing Eu spins-7/2 was previously shown from single-crystal neutron diffraction measurements to exhibit a helical antiferromagnetic (AFM) structure below TN=66.5 K with the helix axis along the c axis and with the ordered moments aligned within the ab plane. Here we report crystallography, electrical resistivity, heat capacity, magnetization, and magnetic susceptibility measurements on single crystals of this compound. We demonstrate that EuCo2P2 is a model molecular-field helical Heisenberg antiferromagnet from comparisons of the anisotropic magnetic susceptibility χ, high-field magnetization, and magnetic heat capacity of EuCo2P2 single crystals at temperature T≤TNmore » with the predictions of our recent formulation of molecular-field theory. Values of the Heisenberg exchange interactions between the Eu spins are derived from the data. The low-T magnetic heat capacity ~T3 arising from spin-wave excitations with no anisotropy gap is calculated and found to be comparable to the lattice heat capacity. The density of states at the Fermi energy of EuCo2P2 and the related compound BaCo2P2 are found from the heat capacity data to be large, 10 and 16 states/eV per formula unit for EuCo2P2 and BaCo2P2, respectively. These values are enhanced by a factor of ~2.5 above those found from DFT electronic structure calculations for the two compounds. Additionally, the calculations also find ferromagnetic Eu–Eu exchange interactions within the ab plane and AFM interactions between Eu spins in nearest- and next-nearest planes, in agreement with the MFT analysis of χab(T≤TN).« less

  6. EuCo2P2: A model molecular-field helical Heisenberg antiferromagnet

    DOE PAGES

    Sangeetha, N. S.; Cuervo-Reyes, Eduardo; Pandey, Abhishek; Johnston, D. C.

    2016-07-19

    Here, the metallic compound EuCo2P2 with the body-centered tetragonal ThCr2Si2 structure containing Eu spins-7/2 was previously shown from single-crystal neutron diffraction measurements to exhibit a helical antiferromagnetic (AFM) structure below TN=66.5 K with the helix axis along the c axis and with the ordered moments aligned within the ab plane. Here we report crystallography, electrical resistivity, heat capacity, magnetization, and magnetic susceptibility measurements on single crystals of this compound. We demonstrate that EuCo2P2 is a model molecular-field helical Heisenberg antiferromagnet from comparisons of the anisotropic magnetic susceptibility χ, high-field magnetization, and magnetic heat capacity of EuCo2P2 single crystals at temperaturemore » T ≤ TN with the predictions of our recent formulation of molecular-field theory. Values of the Heisenberg exchange interactions between the Eu spins are derived from the data. The low-T magnetic heat capacity ~T3 arising from spin-wave excitations with no anisotropy gap is calculated and found to be comparable to the lattice heat capacity. The density of states at the Fermi energy of EuCo2P2 and the related compound BaCo2P2 are found from the heat capacity data to be large, 10 and 16 states/eV per formula unit for EuCo2P2 and BaCo2P2, respectively. These values are enhanced by a factor of ~2.5 above those found from DFT electronic structure calculations for the two compounds. The calculations also find ferromagnetic Eu–Eu exchange interactions within the ab plane and AFM interactions between Eu spins in nearest- and next-nearest planes, in agreement with the MFT analysis of χab(T ≤ TN).« less

  7. A possible hadronic excess in psi(2S) decay and the rho pi puzzle

    SciTech Connect

    Suzuki, Mahiko

    2000-11-09

    We study the so-called {rho}{pi} puzzle of the {psi}(2S) decay by incorporating two inputs; the relative phase between the one-photon and the gluonic decay amplitude, and a possible hadronic excess in the inclusive nonelectromagnetic decay rate of {psi}(2S). We look into the possibility that the hadronic excess in {psi}(2S) originates from a decay process of long-distance origin which is absent from the J/{upsilon} decay. We propose that the amplitude of this additional process happens to nearly cancel the short-distance gluonic amplitude in the exclusive decay {psi}(2S) {yields} 1{sup -}0{sup -} and turn the sum dominantly real in contrast to the J/{psi} decay. We present general consequences of this mechanism and survey two models which might possibly explain the source of this additional amplitude.

  8. Photoexcitation and photoionization from the 2p53p[5/2]2,3 levels in neon

    NASA Astrophysics Data System (ADS)

    Baig, M. A.; Bokhari, I. A.; Rafiq, M.; Kalyar, M. A.; Hussian, T.; Ali, Raheel; Piracha, N. K.

    2011-07-01

    We present measurements of the excitation spectra from the 2p53p [5/2]3,2 levels in neon using two-step laser excitation and ionization in conjunction with an optogalvanic detection in dc and rf discharge cells. The 2p53p [5/2]3,2 intermediate levels have been approached via the collisionally populated 2p53s [3/2]2 metastable level. The Rydberg series 2p5(2P3/2)nd [7/2]4 (12 ⩽ n ⩽ 44), 2p5(2P3/2)ns [3/2]2 (13 ⩽ n ⩽ 35) and the parity forbidden transitions 2p5(2P3/2)np [5/2]3 (13 ⩽ n ⩽ 19) have been observed from the 2p53p [5/2]3 level, whereas the 2p5(2P3/2)nd [7/2]3 (12 ⩽ n ⩽ 44), 2p5(2P3/2)ns [3/2]2 (13 ⩽ n ⩽ 35), and 2p5(2P1/2)nd' [5/2]3 (9 ⩽ n ⩽ 12) Rydberg series have been observed from the 2p53p[5/2]2 level in accordance with the ΔJ = ΔK = ± 1 selection rules. The photoionization cross sections from the 2p53p [5/2]3 intermediate level have been measured at eight ionizing laser wavelengths (399, 395, 390, 385, 380, 370, 364, and 355 nm) and that from the 2p53p [5/2]2 level at 401.8 nm. These measurements are in excellent agreement with the experimental values reported in the literature, while the experimental data lie much below the theoretically calculated photoionization cross sections curve.

  9. Radiative Leptonic B Decays

    SciTech Connect

    Chen, Edward Tann

    2007-01-01

    We present the results of a search for B+ meson decays into γℓ+v, where ℓ = e,μ. We use a sample of 232 million B$\\bar{B}$ meson pairs recorded at the Υ(4S) resonance with the BABAR detector at the PEP-II B factory. We measure a partial branching fraction Δβ in a restricted region of phase space that reduces the effect of theoretical uncertainties, requiring the lepton energy to be in the range 1.875 and 2.850 GeV, the photon energy to be in the range 0.45 and 2.35 GeV, and the cosine of the angle between the lepton and photon momenta to be less than -0.36, with all quantities computed in the Υ(4S) center-of-mass frame. We find Δβ(B+ → γℓ+v) = (-0.31.5+1.3(statistical) -0.6+0.6(systematic) ± 0.1(theoretical)) x 10-6, under the assumption of lepton universality. Interpreted as a 90% confidence-level Bayesian upper limit, the result corresponds to 1.7 x 10-6 for a prior at in amplitude, and 2.3 x 10-6 for a prior at in branching fraction.

  10. RARE DECAYS INCLUDING PENGUINS

    SciTech Connect

    Eigen, G

    2003-12-04

    The authors present a preliminary measurement of the exclusive charmless semileptonic B decays, B {yields} {rho}{ell}{nu}, and the extraction of the CKM parameters V{sub ub}. IN a data sample of 55 x 10{sup 6} B{bar B} events they measure a branching fraction of {Beta}(B {yields} {rho}{ell}{nu}) = (3.39 {+-} 0.44{sub stat} {+-} 0.52{sub sys} {+-} 0.60{sub th}) x 10{sup -4} yielding |V{sub ub}| = (3.69 {+-} 0.23{sub stat} {+-} 0.27{sub sys -0.59th}{sup +0.40}) x 10{sup -3}. Next, they report on a preliminary study of the radiative penguin modes B {yields} K{ell}{sup +}{ell}{sup -} and B {yields} K*{ell}{sup +}{ell}{sup -}. In a data sample of 84 x 10{sup 6} B{bar B} events they observe a significant signal (4.4{sigma}) in B {yields} K{ell}{sup +}{ell}{sup -}, yielding a branching fraction of {Beta}(B {yields} K{ell}{sup +}{ell}{sup -}) = (0.78{sub -0.20-0.18}{sup +0.24+0.11}) x 10{sup -6}. In B {yields} K*{ell}{sup +}{ell}{sup -} the observed yield is not yet significant (2.8{sigma}), yielding an upper limit of the branching fraction of {Beta}(B {yields} K*{ell}{sup +}{ell}{sup -}) 3.0 x 10{sup -6} {at} 90% confidence level. Finally, they summarize preliminary results of searches for B {yields} {rho}({omega}){gamma}, B{sup +} {yields} K{sup +} {nu}{bar {nu}} and B{sup 0} {yields} {ell}{sup +}{ell}{sup -}.

  11. Theoretical Stark widths and shifts of spectral lines of 2p5nf and 2p55g configurations of Mg III

    NASA Astrophysics Data System (ADS)

    Moreno-Díaz, Cristina; Alonso-Medina, Aurelia; Colón, Cristóbal

    2014-11-01

    In this paper, we report theoretical Stark widths and shifts calculated using the Griem semi-empirical approach, which corresponds to 111 spectral lines of Mg III. The values of these Stark broadening parameters of spectral lines that arise from levels of 2p5nf and 2p55g configurations of Mg III are presented in the literature for the first time. The aim of this work is to provide values to estimate the electron density of plasma Mg III in astrophysics and industrial applications. The data are presented for the temperatures T = 0.5-10.0 (104 K) and for an electron density of 1017 cm-3. The matrix of elements used in these calculations has been determined from 23 configurations of Mg III: 2s22p6, 2s22p53p, 2s22p54p, 2s22p54f and 2s22p55f for the even parity and 2s22p5ns (n = 3-6), 2s22p5nd (n = 3-9), 2s22p55g and 2s2p6np (n = 3-8) for the odd parity. For the intermediate coupling calculations, we use the standard method of least square fitting from experimental energy levels by means of Cowan’s computer code. Lines with wavelengths of 134.6460, 135.2800, 189.0380, 190.0043, 192.8424, 408.2939 and 409.4375 nm have high probabilities and also have high values of broadening. Therefore, these lines can be used in some applications. A common regularity for the Stark width of the 189.038 nm spectral line of Mg III is discussed.

  12. The Role of Vibrational Excitation on the Dynamics of the F(^2P) + HCl → FH + Cl(2P) Hydrogen-Transfer Reaction

    NASA Astrophysics Data System (ADS)

    Ray, Sara E.; Vissers, G. W. M.; McCoy, Anne B.

    2010-06-01

    Recently, open-shell systems have gained interest in experimental and theoretical science. What proves interesting about these open-shell systems is that the potential energy surfaces often contain a van der Waals well in the reactant or product channel that allows researchers to probe the pre-reactive species. Here we present the results of time-dependent quantum wave packet calculations on the asymmetric hydrogen-transfer reaction of F(^SUP>2P) + HCl. In these calculations, the reaction is initiated by vibrationally exciting the HCl stretching motion of the pre-reactive F\\cdotsHCl complex in the van der Waals well. The wave packet is propagated on a three-dimensional, fully coupled potential energy surface that has been constructed based on electronic energies calculated at the multi-reference configuration interation+Davidson correction (MRCI+Q) level of theory with an aug-cc-pVnZ (n=2,3,4) basis. Product state distributions were calculated for reactions initiated in the first three vibrationally excited states of HCl, v=1, 2, and 3. Specifically, we analyzed the final electronic, vibrational, and rotational distributions. Previous studies on the hydrogen-transfer reaction of the Cl(^2P) + HCl system focused on whether vibrational excitation of the HCl stretch would promote the reaction and if so, how the reaction dynamics reflect the coupling among the diabatic potential surfaces that describe this system. We also compare our F(^2P) + HCl results to those of this related system. M. P. Deskevich, M. Y. Hayes, K. Takahashi, R. T. Skodje, and D. J. Nesbitt J. Chem. Phys., 124(22) 224303 (2006) G. W. M. Vissers and A. B. McCoy J. Phys Chem. A, 110 5978 (2006)

  13. Raman spectroscopic study of (Ph 2P) 2CCH 2 and [(Ph 2P) 2CCH 2]W(CO) 4

    NASA Astrophysics Data System (ADS)

    Fickert, C.; Posset, U.; Kiefer, W.

    1997-06-01

    The Raman and IR spectra of 1,1-bis[diphenylphosphino]ethene (Ph 2P) 2CCH 2 (vdpp) and the tetracarbonyl tungsten complex (vdpp)W(CO) 4 have been recorded. Vibrational assignments are proposed based on local symmetry considerations. For the vinylidene stretching mode a coordination shift is observed from 1588 cm -1 in polycrystalline vdpp to 1581 cm -1 in its tetracarbonyl tungsten complex. From a comparison of the v(CO) splitting pattern with those of related complexes monoclinic structure with factor group C2h and four formula units per unit cell is concluded.

  14. Synthesis, characterization and photocatalytic performance of PbS/Ni2P flowers

    NASA Astrophysics Data System (ADS)

    Liu, Shuling; Han, Lefang; Liu, Hui

    2016-11-01

    Flower-like PbS/Ni2P composites were synthesized by a facile two-step chemical route. The morphology and structure of the resulting composites were investigated by SEM and TEM images and XRD spectra, respectively. The results showed that the as-obtained composites were composed of the cubic PbS flowers and hexagonal Ni2P nanoparticles, and Ni2P nanoparticles coated on the surfaces of flower-like PbS microstructure. It was found that changing the molar ratio to 3:1, flower-like PbS/Ni2P composites have been successfully synthesized by using cationic cetyltrimethylammonium bromide(CTAB) and anionic sodium dodecyl sulfate (SDS) as template. Furthermore, using methylene blue(MB) as a model organic pollutant, the photocatalytic degradation experiments indicated that the as-prepared composites showed enhanced photocatalytic degradation activity for methylene blue(75%) which is as higher as that of the only flower-like PbS (16.6%) and only Ni2P nanoparticles (44.8%) at the same time. This work may be expected to find its potential application in water pollution treatment.

  15. Saccharomyces cerevisiae phospholipase C regulates transcription of Msn2p-dependent stress-responsive genes.

    PubMed

    Demczuk, Agnieszka; Guha, Nilanjan; Nguyen, Peter H; Desai, Parima; Chang, Jennifer; Guzinska, Katarzyna; Rollins, Janet; Ghosh, Chandra C; Goodwin, Leslie; Vancura, Ales

    2008-06-01

    Phosphatidylinositol phosphates are involved in signal transduction, cytoskeletal organization, and membrane trafficking. Inositol polyphosphates, produced from phosphatidylinositol phosphates by the phospholipase C-dependent pathway, regulate chromatin remodeling. We used genome-wide expression analysis to further investigate the roles of Plc1p (phosphoinositide-specific phospholipase C in Saccharomyces cerevisiae) and inositol polyphosphates in transcriptional regulation. Plc1p contributes to the regulation of approximately 2% of yeast genes in cells grown in rich medium. Most of these genes are induced by nutrient limitation and other environmental stresses and are derepressed in plc1 Delta cells. Surprisingly, genes regulated by Plc1p do not correlate with gene sets regulated by Swi/Snf or RSC chromatin remodeling complexes but show correlation with genes controlled by Msn2p. Our results suggest that the increased expression of stress-responsive genes in plc1 Delta cells is mediated by decreased cyclic AMP synthesis and protein kinase A (PKA)-mediated phosphorylation of Msn2p and increased binding of Msn2p to stress-responsive promoters. Accordingly, plc1 Delta cells display other phenotypes characteristic of cells with decreased PKA activity. Our results are consistent with a model in which Plc1p acts together with the membrane receptor Gpr1p and associated G(alpha) protein Gpa2p in a pathway separate from Ras1p/Ras2p and converging on PKA.

  16. Hypoxia-induced lncRNA-NUTF2P3-001 contributes to tumorigenesis of pancreatic cancer by derepressing the miR-3923/KRAS pathway

    PubMed Central

    Zhu, Shuai; Jin, Yan; Cui, Shi-peng; Chen, Jing-yuan; Xiang, Cheng; Li, Qun-ying; He, Chi; Zhao, Shu-feng; Chen, Heng-yu; Niu, Yi; Liu, Yang; Deng, Shi-chang; Wang, Chun-you; Zhao, Gang

    2016-01-01

    Recent studies indicate that long non-coding RNAs (lncRNAs) play crucial roles in numerous cancers, while their function in pancreatic cancer is rarely elucidated. The present study identifies a functional lncRNA and its potential role in tumorigenesis of pancreatic cancer. Microarray co-assay for lncRNAs and mRNAs demonstrates that lncRNA-NUTF2P3-001 is remarkably overexpressed in pancreatic cancer and chronic pancreatitis tissues, which positively correlates with KRAS mRNA expression. After downregulating lncRNA-NUTF2P3-001, the proliferation and invasion of pancreatic cancer cell are significantly inhibited both in vitro and vivo, accompanying with decreased KRAS expression. The dual-luciferase reporter assay further validates that lncRNA-NUTF2P3-001 and 3′UTR of KRAS mRNA competitively bind with miR-3923. Furthermore, miR-3923 overexpression simulates the inhibiting effects of lncRNA-NUTF2P3-001-siRNA on pancreatic cancer cell, which is rescued by miR-3923 inhibitor. Specifically, the present study further reveals that lncRNA-NUTF2P3-001 is upregulated in pancreatic cancer cells under hypoxia and CoCl2 treatment, which is attributed to the binding of hypoxia-inducible factor-1α (HIF-1α) to hypoxia response elements (HREs) in the upstream of KRAS promoter. Data from pancreatic cancer patients show a positive correlation between lncRNA-NUTF2P3-001 and KRAS, which is associated with advanced tumor stage and worse prognosis. Hence, our data provide a new lncRNA-mediated regulatory mechanism for the tumor oncogene KRAS and implicate that lncRNA-NUTF2P3-001 and miR-3923 can be applied as novel predictors and therapeutic targets for pancreatic cancer. PMID:26755660

  17. A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.

    PubMed

    Shoji, Haruka; Kiniwa, Yukiko; Okuyama, Ryuhei; Yang, Mu; Higuchi, Keiichi; Mori, Masayuki

    2015-01-01

    The original pink-eyed dilution (p) on chromosome 7 is a very old spontaneous mutation in mice. The oculocutaneous albinism II (Oca2) gene has previously been identified as the p gene. Oca2 transcripts have been shown to be absent in the skin of SJL/J mice with the original p mutant allele (Oca2(p)); however, the molecular genetic lesion underlying the original Oca2(p) allele has never been reported. The NCT mouse (commonly known as Nakano cataract mouse) has a pink-eyed dilution phenotype, which prompted us to undertake a molecular genetic analysis of the Oca2 gene of this strain. Our genetic linkage analysis suggests that the locus for the pink-eyed dilution phenotype of NCT is tightly linked to the Oca2 locus. PCR cloning and nucleotide sequence analysis indicates that the NCT mouse has a nonsense nucleotide substitution at exon 7 of the Oca2 gene. Examination of three mouse strains (NZW/NSlc, SJL/J, and 129X1/SvJJmsSlc) with the original Oca2(p) allele revealed the presence of a nonsense nucleotide substitution identical to that in the NCT strain. RT-PCR analysis revealed that the Oca2 transcripts were absent in the skin of NCT mice, suggesting intervention of the nonsense-mediated mRNA decay pathway. Collectively, the data in this study indicate that the nonsense nucleotide substitution in the Oca2 gene underlies the Oca2(p) allele. Our data also indicate that the NCT mouse can be used not only as a cataract model, but also as a model for human type II oculocutaneous albinism.

  18. A nonsense nucleotide substitution in the oculocutaneous albinism II gene underlies the original pink-eyed dilution allele (Oca2(p)) in mice.

    PubMed

    Shoji, Haruka; Kiniwa, Yukiko; Okuyama, Ryuhei; Yang, Mu; Higuchi, Keiichi; Mori, Masayuki

    2015-01-01

    The original pink-eyed dilution (p) on chromosome 7 is a very old spontaneous mutation in mice. The oculocutaneous albinism II (Oca2) gene has previously been identified as the p gene. Oca2 transcripts have been shown to be absent in the skin of SJL/J mice with the original p mutant allele (Oca2(p)); however, the molecular genetic lesion underlying the original Oca2(p) allele has never been reported. The NCT mouse (commonly known as Nakano cataract mouse) has a pink-eyed dilution phenotype, which prompted us to undertake a molecular genetic analysis of the Oca2 gene of this strain. Our genetic linkage analysis suggests that the locus for the pink-eyed dilution phenotype of NCT is tightly linked to the Oca2 locus. PCR cloning and nucleotide sequence analysis indicates that the NCT mouse has a nonsense nucleotide substitution at exon 7 of the Oca2 gene. Examination of three mouse strains (NZW/NSlc, SJL/J, and 129X1/SvJJmsSlc) with the original Oca2(p) allele revealed the presence of a nonsense nucleotide substitution identical to that in the NCT strain. RT-PCR analysis revealed that the Oca2 transcripts were absent in the skin of NCT mice, suggesting intervention of the nonsense-mediated mRNA decay pathway. Collectively, the data in this study indicate that the nonsense nucleotide substitution in the Oca2 gene underlies the Oca2(p) allele. Our data also indicate that the NCT mouse can be used not only as a cataract model, but also as a model for human type II oculocutaneous albinism. PMID:25736709

  19. CP violation in K decays

    SciTech Connect

    Gilman, F.J.

    1989-05-01

    Recent theoretical and experimental progress on the manifestation of CP violation in K decays, and toward understanding whether CP violation originates in a phase, or phases, in the weak mixing matrix of quarks is reviewed. 23 refs., 10 figs.

  20. The Search for Proton Decay.

    ERIC Educational Resources Information Center

    Marshak, Marvin L.

    1984-01-01

    Provides the rationale for and examples of experiments designed to test the stability of protons and bound neutrons. Also considers the unification question, cosmological implications, current and future detectors, and current status of knowledge on proton decay. (JN)

  1. Questions Students Ask: Beta Decay.

    ERIC Educational Resources Information Center

    Koss, Jordan; Hartt, Kenneth

    1988-01-01

    Answers a student's question about the emission of a positron from a nucleus. Discusses the problem from the aspects of the uncertainty principle, beta decay, the Fermi Theory, and modern physics. (YP)

  2. Lorentz violation and {alpha} decay

    SciTech Connect

    Altschul, Brett

    2009-01-01

    Relating the effective Lorentz violation coefficients for composite particles to the coefficients for their constituent fields is a challenging problem. We calculate the Lorentz violation coefficients relevant to the dynamics of an {alpha} particle in terms of proton and neutron coefficients. The {alpha}-particle coefficients would lead to anisotropies in the {alpha} decays of nuclei, and because the decay process involves quantum tunneling, the effects of any Lorentz violations could be exponentially enhanced.

  3. Lifetime and fragment correlations for the two-neutron decay of 26O ground state.

    PubMed

    Grigorenko, L V; Mukha, I G; Zhukov, M V

    2013-07-26

    The structure and decay of 26O are investigated in a three-body 24O+n+n model suitable for studies of the long-lived (including radioactivity time scale) states. We have found extremely strong effects of the subbarrier configuration mixing on the decay width of true 2n emitters due to core recoil and neutron-neutron final state interaction. This effect far exceeds the analogous effect in the true 2p emitters. Our calculations provide reasonably narrow boundaries for the lifetime vs decay energy dependence for the true 2n emission. An upper limit of ∼1  keV for the decay energy of the unbound 26O is inferred based on the recent experimental lifetime value.

  4. Reionization and dark matter decay

    NASA Astrophysics Data System (ADS)

    Oldengott, Isabel M.; Boriero, Daniel; Schwarz, Dominik J.

    2016-08-01

    Cosmic reionization and dark matter decay can impact observations of the cosmic microwave sky in a similar way. A simultaneous study of both effects is required to constrain unstable dark matter from cosmic microwave background observations. We compare two reionization models with and without dark matter decay. We find that a reionization model that fits also data from quasars and star forming galaxies results in tighter constraints on the reionization optical depth τreio, but weaker constraints on the spectral index ns than the conventional parametrization. We use the Planck 2015 data to constrain the effective decay rate of dark matter to Γeff < 2.9 × 10-25/s at 95% C.L. This limit is robust and model independent. It holds for any type of decaying dark matter and it depends only weakly on the chosen parametrization of astrophysical reionization. For light dark matter particles that decay exclusively into electromagnetic components this implies a limit of Γ < 5.3 × 10-26/s at 95% C.L. Specifying the decay channels, we apply our result to the case of keV-mass sterile neutrinos as dark matter candidates and obtain constraints on their mixing angle and mass, which are comparable to the ones from the diffuse X-ray background.

  5. Reionization and dark matter decay

    NASA Astrophysics Data System (ADS)

    Oldengott, Isabel M.; Boriero, Daniel; Schwarz, Dominik J.

    2016-08-01

    Cosmic reionization and dark matter decay can impact observations of the cosmic microwave sky in a similar way. A simultaneous study of both effects is required to constrain unstable dark matter from cosmic microwave background observations. We compare two reionization models with and without dark matter decay. We find that a reionization model that fits also data from quasars and star forming galaxies results in tighter constraints on the reionization optical depth τreio, but weaker constraints on the spectral index ns than the conventional parametrization. We use the Planck 2015 data to constrain the effective decay rate of dark matter to Γeff < 2.9 × 10‑25/s at 95% C.L. This limit is robust and model independent. It holds for any type of decaying dark matter and it depends only weakly on the chosen parametrization of astrophysical reionization. For light dark matter particles that decay exclusively into electromagnetic components this implies a limit of Γ < 5.3 × 10‑26/s at 95% C.L. Specifying the decay channels, we apply our result to the case of keV-mass sterile neutrinos as dark matter candidates and obtain constraints on their mixing angle and mass, which are comparable to the ones from the diffuse X-ray background.

  6. Prognostic value of replication errors on chromosomes 2p and 3p in non-small-cell lung cancer.

    PubMed Central

    Pifarré, A.; Rosell, R.; Monzó, M.; De Anta, J. M.; Moreno, I.; Sánchez, J. J.; Ariza, A.; Mate, J. L.; Martińez, E.; Sánchez, M.

    1997-01-01

    As chromosomes 2p and 3p are frequent targets for genomic instability in lung cancer, we have addressed whether alterations of simple (CA)n DNA repeats occur in non-small-cell lung cancer (NSCLC) at early stages. We have analysed by polymerase chain reaction (PCR) assay replication errors (RER) and loss of heterozygosity (LOH) at microsatellites mapped on chromosomes 2p and 3p in 64 paired tumour-normal DNA samples from consecutively resected stage I, II or IIIA NSCLC. DNA samples were also examined for K-ras and p53 gene mutations by PCR-single-stranded conformational polymorphism (PCR-SSCP) analysis and cyclic sequencing, as well as their relationship with clinical outcome. Forty-two of the 64 (66%) NSCLC patients showed RER at single or multiple loci. LOH was detected in 23 tumours (36%). Among patients with stage I disease, the 5-year survival rate was 80% in those whose tumours had no evidence of RER and 26% in those with RER (P = 0.005). No correlation was established between RER phenotype and LOH, K-ras or p53 mutations. RER remained a strong predictive factor (hazard ratio for death, 2.89; 95% confidence interval, 2.23-3.79; P = 0.002) after adjustment for all other evaluated factors, including p53, K-ras, LOH, histological type, tumour differentiation and TNM stage, suggesting that microsatellite instability on chromosomes 2p and 3p may play a role in NSCLC progression through a different pathway from the traditional tumour mechanisms of oncogene activation and/or tumour-suppressor gene inactivation. Images Figure 1 PMID:9010024

  7. pH-Sensitive K(+) Currents and Properties of K2P Channels in Murine Hippocampal Astrocytes.

    PubMed

    Weller, Johannes; Steinhäuser, Christian; Seifert, Gerald

    2016-01-01

    Based on their intimate spatial association with synapses and the capillary, astrocytes are critically involved in the control of ion, transmitter, and energy homeostasis as well as regulation of the cerebral blood flow. Under pathophysiological conditions, dysfunctional astrocytes can no longer assure homeostatic control although the underlying mechanisms are poorly understood. Specifically, neurological diseases are often accompanied by acidification of the extracellular space, but the properties of astrocytes in such an acidic environment are still a matter of debate. To meet the homeostatic requirements, astrocytes are equipped with intercellular gap junctions, inwardly rectifying K(+) (Kir) channels, and two-pore domain K(+) (K2P) channels. One goal of the present study was to overview current knowledge about astrocyte K(+) channel function during acidosis. In addition, we combined functional and molecular analyses to clarify how low pH affects K(+) channel function in astrocytes freshly isolated from the developing mouse hippocampus. Extracellular acidification led to a decrease of K(+) currents in astrocytes, probably due to modulation of Kir4.1 channels. After blocking Kir4.1 channels, low pH enhanced K(+) current amplitudes. This current activation was mimicked by modulators of TREK-1 channels, which belong to the K2P channels family. We found no evidence for the presence of acid-sensitive ion channels and transient receptor potential vanilloid receptors in hippocampal astrocytes. In conclusion, the assembly of astrocytic K(+) channels allows tolerating short, transient acidification, and glial Kir4.1 and K2P channels can be considered promising new targets in brain diseases accompanied by pH shifts. PMID:26920692

  8. A hybrid CDN-P2P system for Earth observation data delivery

    NASA Astrophysics Data System (ADS)

    Liu, Yi; Li, Bin; Gong, Jianya; Guo, Wei

    2008-12-01

    This paper presents a P2P approach to the delivery of earth-observation data. Conventional P2P networks can speed up data delivery but suffers the problem of stability when handling spatial data. We design a hybrid CDN-P2P strategy to speed up data delivery while maintaining stability. We tested our strategy in a simulation environment in which performance of data transfer is observed against different bandwidths. The results show that the hybrid approach performs much better than the conventional only-server and only-peers model. Dynamic allocation of peers and predownload are also presented as strategies to address the special needs of spatial data delivery.

  9. Kinetic-arrest-induced phase coexistence and metastability in (Mn,Fe ) 2(P ,Si )

    NASA Astrophysics Data System (ADS)

    Miao, X. F.; Mitsui, Y.; Dugulan, A. Iulian; Caron, L.; Thang, N. V.; Manuel, P.; Koyama, K.; Takahashi, K.; van Dijk, N. H.; Brück, E.

    2016-09-01

    Neutron diffraction, Mössbauer spectroscopy, magnetometry, and in-field x-ray diffraction are employed to investigate the magnetoelastic phase transition in hexagonal (Mn,Fe ) 2(P ,Si ) compounds. (Mn,Fe ) 2(P ,Si ) compounds undergo for certain compositions a second-order paramagnetic (PM) to a spin-density-wave (SDW) phase transition before further transforming into a ferromagnetic (FM) phase via a first-order phase transition. The SDW-FM transition can be kinetically arrested, causing the coexistence of FM and untransformed SDW phases at low temperatures. Our in-field x-ray diffraction and magnetic relaxation measurements clearly reveal the metastability of the untransformed SDW phase. This unusual magnetic configuration originates from the strong magnetoelastic coupling and the mixed magnetism in hexagonal (Mn,Fe ) 2(P ,Si ) compounds.

  10. A resources monitoring architecture for P2P file-sharing systems

    NASA Astrophysics Data System (ADS)

    Wang, Wenxian; Chen, Xingshu; Wang, Haizhou

    2013-07-01

    Resources monitoring is an important problem of the overall efficient usage and control of P2P file-sharing systems. The resources of file-sharing systems can include all distributing servers, programs and peers. Several researches have tried to address this issue, but most of them illuminated P2P traffic characterization, identification and user behavior. Based on previous work, we present a resources monitoring architecture for P2P file-sharing systems. The monitoring architecture employs a hierarchical structure and provides systemic monitoring including resources discovery, relative information extraction and analysis, trace and location. It gives a systematic framework for file-sharing resources monitoring. And a prototype system has been developed based on the framework.

  11. Atomic resolution crystal structure of Sapp2p, a secreted aspartic protease from Candida parapsilosis.

    PubMed

    Dostál, Jiří; Pecina, Adam; Hrušková-Heidingsfeldová, Olga; Marečková, Lucie; Pichová, Iva; Řezáčová, Pavlina; Lepšík, Martin; Brynda, Jiří

    2015-12-01

    The virulence of the Candida pathogens is enhanced by the production of secreted aspartic proteases, which therefore represent possible targets for drug design. Here, the crystal structure of the secreted aspartic protease Sapp2p from Candida parapsilosis was determined. Sapp2p was isolated from its natural source and crystallized in complex with pepstatin A, a classical aspartic protease inhibitor. The atomic resolution of 0.83 Å allowed the protonation states of the active-site residues to be inferred. A detailed comparison of the structure of Sapp2p with the structure of Sapp1p, the most abundant C. parapsilosis secreted aspartic protease, was performed. The analysis, which included advanced quantum-chemical interaction-energy calculations, uncovered molecular details that allowed the experimentally observed equipotent inhibition of both isoenzymes by pepstatin A to be rationalized.

  12. Atypical features of a Ure2p glutathione transferase from Phanerochaete chrysosporium.

    PubMed

    Thuillier, Anne; Roret, Thomas; Favier, Frédérique; Gelhaye, Eric; Jacquot, Jean-Pierre; Didierjean, Claude; Morel-Rouhier, Mélanie

    2013-07-11

    Glutathione transferases (GSTs) are known to transfer glutathione onto small hydrophobic molecules in detoxification reactions. The GST Ure2pB1 from Phanerochaete chrysosporium exhibits atypical features, i.e. the presence of two glutathione binding sites and a high affinity towards oxidized glutathione. Moreover, PcUre2pB1 is able to efficiently deglutathionylate GS-phenacylacetophenone. Catalysis is not mediated by the cysteines of the protein but rather by the one of glutathione and an asparagine residue plays a key role in glutathione stabilization. Interestingly PcUre2pB1 interacts in vitro with a GST of the omega class. These properties are discussed in the physiological context of wood degrading fungi.

  13. Galactomannan Downregulates the Inflammation Responses in Human Macrophages via NFκB2/p100

    PubMed Central

    Toledano, Víctor; Hernández-Jiménez, Enrique; Cubillos-Zapata, Carolina; Flandez, Marta; Álvarez, Enrique; Varela-Serrano, Aníbal; Cantero, Ramón; Valles, Gema; García-Rio, Francisco; López-Collazo, Eduardo

    2015-01-01

    We show that galactomannan, a polysaccharide consisting of a mannose backbone with galactose side groups present on the cell wall of several fungi, induces a reprogramming of the inflammatory response in human macrophages through dectin-1 receptor. The nuclear factor kappa-light-chain-enhancer of activated B cells 2 (NFκB2)/p100 was overexpressed after galactomannan challenge. Knocking down NFκB2/p100 using small interfering RNA (siRNA) indicated that NFκB2/p100 expression is a crucial factor in the progression of the galactomannan-induced refractoriness. The data presented in this study could be used as a modulator of inflammatory response in clinical situations where refractory state is required. PMID:26441484

  14. High-pressure elastic properties of cubic Ir2P from ab initio calculations

    NASA Astrophysics Data System (ADS)

    Sun, Xiao-Wei; Bioud, Nadhira; Fu, Zhi-Jian; Wei, Xiao-Ping; Song, Ting; Li, Zheng-Wei

    2016-10-01

    A study of the high-pressure elastic properties of new synthetic Ir2P in the anti-fluorite structure is conducted using ab initio calculations based on density functional theory. The elastic constants C11, C12 and C44 for the cubic Ir2P are obtained by the stress-strain method and the elastic stability calculations under pressure indicate that it is stable at least 100 GPa. Additionally, the electronic density of states, the aggregate elastic moduli, that is bulk modulus, shear modulus, and Young's modulus along with the Debye temperature, Poisson's ratio, and elastic anisotropy factor are all successfully obtained. Moreover, the pressure dependence of the longitudinal and shear wave velocities in three different directions [100], [110], and [111] for Ir2P are also predicted for the first time.

  15. Heterogeneous and hyperfine interactions between valence states of molecular iodine correlating with the I(2P1/2) + I(2P1/2) dissociation limit

    NASA Astrophysics Data System (ADS)

    Baturo, Vera V.; Cherepanov, Igor N.; Lukashov, Sergey S.; Poretsky, Sergey A.; Pravilov, Anatoly M.; Zhironkin, Anatoly I.

    2016-05-01

    Detailed analysis of interactions between all 0g + , 1u, and 0u - weakly bound states of iodine molecule correlating with the I(2P1/2) + I(2P1/2) (bb) dissociation limit has been performed. For this purpose, the 0u - (bb) state has been described using analysis of rotationally resolved excitation spectra of luminescence from the g 0g - state populated in a three-step three-color perturbation facilitated excitation scheme via the 0u - state. Energies of 41 rovibrational levels, molecular constants, and potential energy curve have been determined. Energy gaps between closest rovibrational levels of the 0u - and 0g + , 1u (bb) states are found to be large, ˜6 cm-1. However, interaction of all three 0g + , 1u, and 0u - (bb) states has been observed. It has been found that the 0u - and 1u electronic states are mixed by heterogeneous interactions, while their mixing with the 0g + one is due to hyperfine interactions predominantly. Admixture coefficients and electronic matrix elements of the coupling between the 0g + ˜1u, 0g + ˜ 0u - , and 0u - ˜1u states have been estimated.

  16. Evolution of superconductivity and magnetism in La1-xYbxRu2P2

    NASA Astrophysics Data System (ADS)

    Roncaioli, Connor; Hodovanets, Halyna; Saha, Shanta; Paglione, Johnpierre

    LaRu2P2, with a 4.1 K transition, is the first known pnictide-based superconductor. Sharing structural and electronic elements similar to those of the unconventional Fe-pnictide superconductors, it is of interest to investigate the parameter space in which a superconducting ground state survives. We present preliminary indications of more interesting magnetic behavior and structural tuning behavior when paramagnetic Yb is substituted for La in La1-xYbxRu2P2, and investigate potential heavy fermion behavior in the Yb end-member of this series.

  17. Transfer to the continuum calculations of quasifree (p,pn) and (p,2p) reactions

    NASA Astrophysics Data System (ADS)

    Gomez-Ramos, M.; Moro, A. M.

    2016-05-01

    Nucleon removal (p, pn) and (p, 2p) reactions at intermediate energies have gained renewed attention in recent years as a tool to extract information from exotic nuclei. The information obtained from these experiments is expected to be sensitive to deeper portions of the wave function of the removed nucleon than knockout reactions with heavier targets. In this contribution, we present calculations for (p, 2p) and (p, pn) reactions performed within the so-called transfer to the continuum method (TR*). Results for stable and unstable nuclei are presented, and compared with experimental data, when available.

  18. Are 2P/Encke, the Taurid complex NEOs and CM chondrites related?

    NASA Astrophysics Data System (ADS)

    Tubiana, C.; Snodgrass, C.; Michelsen, R.; Haack, H.; Fitzsimmons, A.; Williams, I.; Boehnhardt, H.

    2013-09-01

    Comet 2P/Encke is a short-period comet that was discovered in 1786 and has been extensively observed and studied for more than 200 years. It has an orbital period of 3.3 years and its orbit is dynamically decoupled from Jupiter's control due to gravitational interaction with terrestrial planets [6]. It is the only comet known on such an orbit, making it unique. Capture from the outer solar system onto its current orbit is very unlikely and even a continuous smooth dynamical evolution has a low probability as this requires a continuous period when it is dormant in order to avoid the volatiles from the nucleus becoming exhausted and making the current observed activity impossible. An origin in the asteroid belt is a possibility especially in view of the recently discovered main belt comets. The nucleus of 2P/Encke is dark (geometric albedo of 0.047 ± 0.023 [3]), has an effective radius of 2.4 ± 0.3 km [3] and it has polarimetric properties that are unique compared to other measured types of solar system objects, such as asteroids, TNOs, cometary dust, Centaurs [2]. The colors of 2P/Encke's nucleus are typical for comets, but no spectra of the nucleus in the visible wavelength range exist so far. The Taurid meteoroid stream has long been linked with 2P/Encke, but the activity of the comet is not strong enough to explain the number of observed meteors. It has been suggested that the meteoroid stream was caused by the break up of a larger parent body, which left comet 2P/Encke and other various small bodies along with a stream of dust. Various small near-Earth objects (NEOs) have been discovered with orbits that can be linked with 2P/Encke and the Taurid meteoroid stream [1]. Though many of the associations are spurious due to the low inclination of 2P/Encke's orbit, many NEO's have evolved in a similar way to 2P/Encke overa period of 5000 years [8] suggesting some relationship. In addition to dynamical properties, common taxonomic properties can also provide an

  19. Design and implementation of telemetry seismic data acquisition system based on embedded P2P Ethernet

    NASA Astrophysics Data System (ADS)

    Zhang, L.; Lin, J.; Chen, Z.

    2011-12-01

    A new design of telemetry seismic data acquisition system is presented which uses embedded, point to point (P2P) Ethernet networks. In our presentation, we explain the idea and motivation behind the use of P2P Ethernet topology and show the problems when such topology is used in seismic acquisition system. The presented paper focuses on the network protocols developed by us which include the generation of route table and dynamic IP address management. This new design has been implemented based on ARM and FPGA, which we have tested in laboratory and seismic exploration.

  20. Quantum electrodynamics corrections to the 2P fine splitting in Li.

    PubMed

    Puchalski, Mariusz; Pachucki, Krzysztof

    2014-08-15

    We consider quantum electrodynamics (QED) corrections to the fine splitting E(2P_{3/2})-E(2P_{1/2}) in the Li atom. We derive complete formulas for the mα^{6} and mα^{7}lnα contributions and calculate them numerically using highly optimized, explicitly correlated basis functions. The obtained results are in agreement with the most recent measurement, helping to resolve discrepancies between former ones and lay the foundation for the investigation of QED effects in light, many-electron atoms.

  1. The circumferential actomyosin belt in epithelial cells is regulated by the Lulu2-p114RhoGEF system

    PubMed Central

    Nakajima, Hiroyuki; Tanoue, Takuji

    2012-01-01

    In epithelial cells, myosin-II-dependent forces regulate many aspects of animal morphogenesis, such as apical constriction, cell intercalation, cell sorting, and the formation and maintenance of the adherens junction. These forces are mainly generated by the circumferential actomyosin belt, which is composed of F-actin–myosin II bundles located along apical cell–cell junctions. Although several of the molecular pathways regulating the belt have been identified, the precise mechanisms underlying its function are largely unknown. Our recent studies identified Lulu proteins (Lulu1 and Lulu2), FERM-domain-containing molecules, as the regulators of the belt. Lulus activate the circumferential actomyosin belt and thereby induce apical constriction in epithelial cells; conversely, RNAi-mediated Lulu-knockdown results in the severe disorganization of the circumferential actomyosin belt. We also showed that p114RhoGEF is a downstream molecule of Lulu2 in its regulation of the belt; Lulu2 enhances the catalytic activity of p114RhoGEF through a direct interaction and thereby activates the circumferential actomyosin belt. We further identified aPKC and Patj as regulators of Lulu2-p114RhoGEF. In this commentary, we discuss current knowledge of the circumferential actomyosin belt's regulation, focusing on the Lulu2-p114RhoGEF system. PMID:22790195

  2. α -decay chains of recoiled superheavy nuclei: A theoretical study

    NASA Astrophysics Data System (ADS)

    Niyti, Sawhney, Gudveen; Sharma, Manoj K.; Gupta, Raj K.

    2015-05-01

    A systematic theoretical study of α -decay half-lives in the superheavy mass region of the periodic table of elements is carried out by extending the quantum-mechanical fragmentation theory based on the preformed cluster model (PCM) to include temperature (T ) dependence in its built-in preformation and penetration probabilities of decay fragments. Earlier, the α -decay chains of the isotopes of Z =115 were investigated by using the standard PCM for spontaneous decays, with"hot-optimum" orientation effects included, which required a constant scaling factor of 104 to approach the available experimental data. In the present approach of the PCM (T ≠0 ), the temperature effects are included via the recoil energy of the residual superheavy nucleus (SHN) left after x -neutron emission from the superheavy compound nucleus. The important result is that the α -decay half-lives calculated by the PCM (T ≠0 ) match the experimental data nearly exactly, without using any scaling factor of the type used in the PCM. Note that the PCM (T ≠0 ) is an equivalent of the dynamical cluster-decay model for heavy-ion collisions at angular momentum ℓ =0 . The only parameter of model is the neck-length parameter Δ R , which for the calculated half-lives of α -decay chains of various isotopes of Z =113 to 118 nuclei formed in "hot-fusion" reactions is found to be nearly constant, i.e., Δ R ≈0.95 ±0.05 fm for all the α -decay chains studied. The use of recoiled residue nucleus as a secondary heavy-ion beam for nuclear reactions has also been suggested in the past.

  3. MUON DECAY ASYMMETRIES FROM KOL YIELDS POM+M-DECAYS.

    SciTech Connect

    DIWAN, M.V.; MA, H.; TRUEMAN, T.L.

    2001-06-12

    We have examined the decay K{sub L}{sup 0} {yields} {pi}{sup 0} {mu}{sup +} {mu}{sup -} in which the branching ratio, the muon energy asymmetry and the muon decay asymmetry could be measured. In particular, we find that within the Standard Model the longitudinal polarization (PL) of the muon is proportional to the direct CP violating amplitude. On the other hand the energy asymmetry and the out-of-plane polarization (P{sub N}) depend on both indirect and direct CP violating amplitudes. Although the branching ratio is small and difficult to measure because of background, the asymmetries could be large {Omicron}(1) in the Standard Model. A combined analysis of the energy asymmetry, P{sub L} and P{sub N} could be used to separate indirect, CPV, direct CPV, and CP conserving contributions to the decay.

  4. Dim2p, a KH-domain protein required for small ribosomal subunit synthesis

    PubMed Central

    VANROBAYS, EMMANUEL; GÉLUGNE, JEAN-PAUL; CAIZERGUES-FERRER, MICHÈLE; LAFONTAINE, DENIS L.J.

    2004-01-01

    Recent proteomic analyses are revealing the dynamics of preribosome assembly. Following cleavage at processing site A2, which generates the 20S pre-rRNA (the immediate precursor to the 18S rRNA), early RRPs (ribosomal RNA processing factors) are released in bulk from the preribosomes, and the resulting pre-40S subunits are left associated with a limited set of proteins that we refer to as the SSU RRP complex. Dim2p, a core constituent of the SSU RRP complex and conserved KH-domain containing protein, is required for pre-rRNA processing and is associated with early nucleolar and late cytoplasmic pre-rRNA species. Consistently, Dim2p shuttles between the nucle(ol)us and the cytoplasm, a trafficking that is tightly regulated by growth. The association of Dim2p with the 18S rRNA dimethyltransferase Dim1p, as well as its requirement for pre-rRNA processing at cleavage sites A1 and A2 and for 18S rRNA dimethylation, suggest that Dim2p may recruit Dim1p to nucleolar pre-rRNAs through its KH domain. PMID:15037774

  5. Al 2p core exciton in AlxGa1-xAs

    NASA Astrophysics Data System (ADS)

    Nithianandam, Jeyasingh; Schnatterly, Stephen E.

    1990-08-01

    Al L2,3 x-ray emission spectra from AlxGa1-xAs of varying aluminum concentration are presented. The nature of the Al 2p core exciton observed in these spectra is discussed. Some comments are also made on the effects of anion disorder in these alloys.

  6. Couplings between Chern-Simons gravities and 2p-branes

    SciTech Connect

    Miskovic, Olivera; Zanelli, Jorge

    2009-08-15

    The interaction between Chern-Simons (CS) theories and localized external sources (2p-branes) is analyzed. This interaction generalizes the minimal coupling between a point charge (0-brane) and a gauge connection. The external currents that define the 2p branes are covariantly constant (D-2p-1)-forms coupled to (2p-1) CS forms. The general expression for the sources--charged with respect to the corresponding gauge algebra--is presented, focusing on two special cases: 0-branes and (D-3)-branes. In any dimension, 0-branes are constructed as topological defects produced by a surface deficit of (D-2)-sphere in anti-de Sitter space, and they are not constant curvature spaces for D>3. They correspond to dimensionally continued black holes with negative mass. On the other hand, in the case of CS (super) gravities, the (D-3)-branes are naked conical singularities (topological defects) obtained by identification of points with a Killing vector. In 2+1 dimensions, extremal spinning branes of this type are Bogomol'nyi-Prasad-Sommerfield states. Stable (D-3)-branes are shown to exist also in higher dimensions, as well. Classical field equations are also discussed, and in the presence of sources there is a large number of inequivalent and disconnected sectors in solution space.

  7. 76 FR 65558 - Rescission of Social Security Ruling 97-2p

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-21

    ... From the Federal Register Online via the Government Publishing Office SOCIAL SECURITY ADMINISTRATION Rescission of Social Security Ruling 97-2p AGENCY: Social Security Administration. ACTION: Notice of rescission of Social Security Ruling. SUMMARY: In accordance with 20 CFR 402.35(b)(1),...

  8. Scalable P2P Overlays of Very Small Constant Degree: An Emerging Security Threat

    NASA Astrophysics Data System (ADS)

    Jelasity, Márk; Bilicki, Vilmos

    In recent years peer-to-peer (P2P) technology has been adopted by Internet-based malware as a fault tolerant and scalable communication medium for self-organization and survival. It has been shown that malicious P2P networks would be nearly impossible to uncover if they operated in a stealth mode, that is, using only a small constant number of fixed overlay connections per node for communication. While overlay networks of a small constant maximal degree are generally considered to be unscalable, we argue in this paper that it is possible to design them to be scalable, efficient and robust. This is an important finding from a security point of view: we show that stealth mode P2P malware that is very difficult to discover with state-of-the-art methods is a plausible threat. In this paper we discuss algorithms and theoretical results that support the scalability of stealth mode overlays, and we present realistic simulations using an event based implementation of a proof-of-concept system. Besides P2P botnets, our results are also applicable in scenarios where relying on a large number of overlay connections per node is not feasible because of cost or the limited number of communication channels available.

  9. Highly efficient acousto-optic diffraction in Sn2P2S6 crystals.

    PubMed

    Martynyuk-Lototska, I Yu; Mys, O G; Grabar, A A; Stoika, I M; Vysochanskii, Yu M; Vlokh, R O

    2008-01-01

    We have studied the acousto-optic (AO) diffraction in Sn2P2S6 crystals and found that they manifest high values of an AO figure of merit. The above crystals may therefore be used as highly efficient materials in different AO applications.

  10. Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase

    PubMed Central

    Cordin, Olivier; Hahn, Daniela; Alexander, Ross; Gautam, Amit; Saveanu, Cosmin; Barrass, J. David; Beggs, Jean D.

    2014-01-01

    RNA helicases are essential for virtually all cellular processes, however, their regulation is poorly understood. The activities of eight RNA helicases are required for pre-mRNA splicing. Amongst these, Brr2p is unusual in having two helicase modules, of which only the amino-terminal helicase domain appears to be catalytically active. Using genetic and biochemical approaches, we investigated interaction of the carboxy-terminal helicase module, in particular the carboxy-terminal Sec63-2 domain, with the splicing RNA helicase Prp16p. Combining mutations in BRR2 and PRP16 suppresses or enhances physical interaction and growth defects in an allele-specific manner, signifying functional interactions. Notably, we show that Brr2p Sec63-2 domain can modulate the ATPase activity of Prp16p in vitro by interfering with its ability to bind RNA. We therefore propose that the carboxy-terminal helicase module of Brr2p acquired a regulatory function that allows Brr2p to modulate the ATPase activity of Prp16p in the spliceosome by controlling access to its RNA substrate/cofactor. PMID:25428373

  11. A Novel Syndrome Affecting Multiple Mitochondrial Functions, Located by Microcell-Mediated Transfer to Chromosome 2p14-2p13

    PubMed Central

    Seyda, Agnieszka; Newbold, Robert F.; Hudson, Thomas J.; Verner, Andrei; MacKay, Neviana; Winter, Susan; Feigenbaum, Annette; Malaney, Suzann; Gonzalez-Halphen, Diego; Cuthbert, Andrew P.; Robinson, Brian H.

    2001-01-01

    We have studied cultured skin fibroblasts from three siblings and one unrelated individual, all of whom had fatal mitochondrial disease manifesting soon after birth. After incubation with 1 mM glucose, these four cell strains exhibited lactate/pyruvate ratios that were six times greater than those of controls. On further analysis, enzymatic activities of the pyruvate dehydrogenase complex, the 2-oxoglutarate dehydrogenase complex, NADH cytochrome c reductase, succinate dehydrogenase, and succinate cytochrome c reductase were severely deficient. In two of the siblings the enzymatic activity of cytochrome oxidase was mildly decreased (by ∼50%). Metabolite analysis performed on urine samples taken from these patients revealed high levels of glycine, leucine, valine, and isoleucine, indicating abnormalities of both the glycine-cleavage system and branched-chain α-ketoacid dehydrogenase. In contrast, the activities of fibroblast pyruvate carboxylase, mitochondrial aconitase, and citrate synthase were normal. Immunoblot analysis of selected complex III subunits (core 1, cyt c1, and iron-sulfur protein) and of the pyruvate dehydrogenase complex subunits revealed no visible changes in the levels of all examined proteins, decreasing the possibility that an import and/or assembly factor is involved. To elucidate the underlying molecular defect, analysis of microcell-mediated chromosome-fusion was performed between the present study's fibroblasts (recipients) and a panel of A9 mouse:human hybrids (donors) developed by Cuthbert et al. (1995). Complementation was observed between the recipient cells from both families and the mouse:human hybrid clone carrying human chromosome 2. These results indicate that the underlying defect in our patients is under the control of a nuclear gene, the locus of which is on chromosome 2. A 5-cM interval has been identified as potentially containing the critical region for the unknown gene. This interval maps to region 2p14-2p13. PMID

  12. Unsolved problems in hadronic charm decay

    SciTech Connect

    Browder, T.E.

    1989-08-01

    This paper describes several outstanding problems in the study of hadronic decays of charmed mesons where further experimental work and theoretical understanding is needed. Four topics are stressed: double Cabibbo suppressed decays (DCSD) of D/sup +/ mesons, hadronic D/sub s/ decays, weak hadronic quasi-two-body decays to pairs of vector mesons, and penguin decays of D mesons. 24 refs., 10 figs., 5 tabs.

  13. Effects of Chitin and Its Derivative Chitosan on Postharvest Decay of Fruits: A Review

    PubMed Central

    Zhang, Hongyin; Li, Renping; Liu, Weimin

    2011-01-01

    Considerable economic losses to harvested fruits are caused by postharvest fungal decay during transportation and storage, which can be significantly controlled by synthetic fungicides. However, considering public concern over pesticide residues in food and the environment, there is a need for safer alternatives for the control of postharvest decay to substitute synthetic fungicides. As the second most abundant biopolymer renewable source in nature, chitin and its derivative chitosan are widely used in controlling postharvest decay of fruits. This review aims to introduce the effect of chitin and chitosan on postharvest decay in fruits and the possible modes of action involved. We found most of the actions discussed in these researches rest on physiological mechanisms. All of the mechanisms are summarized to lay the groundwork for further studies which should focus on the molecular mechanisms of chitin and chitosan in controlling postharvest decay of fruits. PMID:21541034

  14. Decay curve study in a standard electron capture decay

    SciTech Connect

    Nishimura, D.; Fukuda, M.; Kisamori, K.; Kuwada, Y.; Makisaka, K.; Matsumiya, R.; Matsuta, K.; Mihara, M.; Takagi, A.; Yokoyama, R.; Izumikawa, T.; Ohtsubo, T.; Suzuki, T.; Yamaguchi, T.

    2010-05-12

    We have searched for a time-modulated decay in a standard electron capture experiment for {sup 140}Pr, in order to confirm a report from GSI, where an oscillatory decay has been observed for hydrogen-like {sup 140}Pr and {sup 142}Pm ions in the cooler storage ring. {sup 140}Pr has been produced with the {sup 140}Ce(p, n) reaction by a pulsed proton beam accelerated from the Van de Graaff accelerator at Osaka University. Resultant time dependence of the K{sub a}lpha and K{sub b}eta X-ray intensities from the daughter shows no oscillatory behavior.

  15. Multiple regulatory roles of the carboxy terminus of Ste2p a yeast GPCR.

    PubMed

    Kim, Kyeong-Man; Lee, Yong-Hun; Akal-Strader, Ayca; Uddin, M Seraj; Hauser, Melinda; Naider, Fred; Becker, Jeffrey M

    2012-01-01

    Signaling and internalization of Ste2p, a model G protein-coupled receptor (GPCR) from the yeast Saccharomyces cerevisiae, are reported to be regulated by phosphorylation status of serine (S) and threonine (T) residues located in the cytoplasmic C-terminus. Although the functional roles of S/T residues located in certain C-terminus regions are relatively well characterized, systemic analyses have not been conducted for all the S/T residues that are spread throughout the C-terminus. A point mutation to alanine was introduced into the S/T residues located within three intracellular loops and the C-terminus individually or in combination. A series of functional assays such as internalization, FUS1-lacZ induction, and growth arrest were conducted in comparison between WT- and mutant Ste2p. The Ste2p in which all S/T residues in the C-terminus were mutated to alanine was more sensitive to α-factor, suggesting that phosphorylation in the C-terminus exerts negative regulatory activities on the Ste2p signaling. C-terminal S/T residues proximal to the seventh transmembrane domain were important for ligand-induced G protein coupling but not for receptor internalization. Sites on the central region of the C-terminus regulated both constitutive and ligand-induced internalization. Residues on the distal part were important for constitutive desensitization and modulated the G protein signaling mediated through the proximal part of the C-terminus. This study demonstrated that the C-terminus contains multiple functional domains with differential and interdependent roles in regulating Ste2p function in which the S/T residues located in each domain play critical roles. PMID:22100461

  16. Genitourinary Defects Associated with Genomic Deletions in 2p15 Encompassing OTX1

    PubMed Central

    Jorgez, Carolina J.; Rosenfeld, Jill A.; Wilken, Nathan R.; Vangapandu, Hima V.; Sahin, Aysegul; Pham, Dung; Carvalho, Claudia M. B.; Bandholz, Anne; Miller, Amanda; Weaver, David D.; Burton, Barbara; Babu, Deepti; Bamforth, John S.; Wilks, Timothy; Flynn, Daniel P.; Roeder, Elizabeth; Patel, Ankita; Cheung, Sau W.; Lupski, James R.; Lamb, Dolores J.

    2014-01-01

    Normal development of the genitourinary (GU) tract is a complex process that frequently goes awry. In male children the most frequent congenital GU anomalies are cryptorchidism (1–4%), hypospadias (1%) and micropenis (0.35%). Bladder exstrophy and epispadias complex (BEEC) (1∶47000) occurs less frequently but significantly impacts patients' lives. Array comparative genomic hybridization (aCGH) identified seven individuals with overlapping deletions in the 2p15 region (66.0 kb-5.6 Mb). Six of these patients have GU defects, while the remaining patient has no GU defect. These deletions encompass the transcription factor OTX1. Subjects 2–7 had large de novo CNVs (2.39–6.31 Mb) and exhibited features similar to those associated with the 2p15p16.1 and 2p15p14 microdeletion syndromes, including developmental delay, short stature, and variable GU defects. Subject-1 with BEEC had the smallest deletion (66 kb), which deleted only one copy of OTX1. Otx1-null mice have seizures, prepubescent transient growth retardation and gonadal defects. Two subjects have short stature, two have seizures, and six have GU defects, mainly affecting the external genitalia. The presence of GU defects in six patients in our cohort and eight of thirteen patients reported with deletions within 2p14p16.1 (two with deletion of OTX1) suggest that genes in 2p15 are important for GU development. Genitalia defects in these patients could result from the effect of OTX1 on pituitary hormone secretion or on the regulation of SHH signaling, which is crucial for development of the bladder and genitalia. PMID:25203062

  17. A new barium titanium (III) pyrophosphate: BaTi 2(P 2O 7) 2

    NASA Astrophysics Data System (ADS)

    Wang, Shumin; Hwu, Shiou-Jyh

    1991-01-01

    The new barium titanium (III) pyrophosphate BaTi 2(P 2O 7) 2 has been prepared by conventional high temperature solid state reaction at 900°C in a fused silica tube. BaTi 2(P 2O 7) 2 crystallizes with four formula units in a cell with dimensions a = 10.680(3) Å, b = 10.564(4) Å, c = 9.834(4) Å/, β = 102.88(3)° and V = 1081.6(6) Å 3 in space group C 62h  C {2}/{c} (No. 15) of the monoclinic system. The single crystal structure refinement gives a final structure solution with R index on F2o of 0.018 for 99 variables and GOF = 1.05. BaTi 2(P 2O 7) 2 displays a new layered type structure which consists of layers of slightly distorted TiO 6 octahedra with (P 2O 7) and (BaO 10) polyhedra between the layers. The structural framework is built up from corner-sharing TiO 6 octahedra and P 2O 7 pyrophosphate groups, to give rise to [Ti 2(P 2O 7) 2] 2- units and to form tunnels where the barium cations reside. Magnetic susceptibility measurements on selected single crystals confirm the presence of Ti 3+ ( d1) ions with spin S = {1}/{2}. The high oxidative thermal stability of BaTi 2(P 2O 7) 2 versus the stabilities of other trivalent titanium cation-containing compounds, including Ti 2O 3, TiPO 4, and BaTi 2(PO 4) 3, owing to possible anion matrix effects are discussed.

  18. Crystal structure of an archaeal Ski2p-like protein from Pyrococcus horikoshii OT3.

    PubMed

    Zhang, Xiaodong; Nakashima, Takashi; Kakuta, Yoshimitsu; Yao, Min; Tanaka, Isao; Kimura, Makoto

    2008-01-01

    The Ski complex composed of Ski2p, Ski3p, and Ski8p plays an essential role in the 3' to 5' cytoplasmic mRNA degradation pathway in yeast. Ski2p is a putative RNA helicase, belonging in the DExD/H-box protein families and conserved in eukarya as well as in archaea. The gene product (Ph1280p) from the hyperthermophilic archaeon Pyrococcus horikoshii OT3 shows sequence homology with Ski2p, sharing 22.6% identical amino acids with a central region of Ski2p. In order to gain structural information about the Ski2p-like RNA helicase, we overproduced Ph1280p in Escherichia coli cells, and purified it to apparent homogeneity. Ph1280p exhibits DNA/RNA-dependent ATPase activity with an optimal temperature at approximately 90 degrees C. The crystal structure of Ph1280p has been solved at a resolution of 3.5 A using single-wavelength anomalous dispersion (SAD) and selenomethionyl (Se-Met)-substituted protein. Ph1280p comprises four subdomains; the two N-terminal subdomains (N1 and N2) fold into an RecA-like architecture with the conserved helicase motifs, while the two C-terminal subdomains (C1 and C2) fold into alpha-helical structures containing a winged helix (WH)-fold and helix-hairpin-helix (HhH)-fold, respectively. Although the structure of each of the Ph1280p subdomains can be individually superimposed on the corresponding domains in other helicases, such as the Escherichia coli DNA helicase RecQ, the relative orientation of the helicase and C-terminal subdomains in Ph1280p is significantly different from that of other helicases. This structural feature is implicated in substrate specificity for the Ski2-like helicase and would play a critical role in the 3' to 5' cytoplasmic mRNA degradation in the Ski complex. PMID:18042682

  19. α and 2 p 2 n emission in fast neutron-induced reactions on 60Ni

    NASA Astrophysics Data System (ADS)

    Fotiades, N.; Devlin, M.; Haight, R. C.; Nelson, R. O.; Kunieda, S.; Kawano, T.

    2015-06-01

    Background: The cross sections for populating the residual nucleus in the reaction ZAX(n,x) Z -2 A -4Y exhibit peaks as a function of incident neutron energy corresponding to the (n ,n'α ) reaction and, at higher energy, to the (n ,2 p 3 n ) reaction. The relative magnitudes of these peaks vary with the Z of the target nucleus. Purpose: Study fast neutron-induced reactions on 60Ni. Locate experimentally the nuclear charge region along the line of stability where the cross sections for α emission and for 2 p 2 n emission in fast neutron-induced reactions are comparable as a further test of reaction models. Methods: Data were taken by using the Germanium Array for Neutron-Induced Excitations. The broad-spectrum pulsed neutron beam of the Los Alamos Neutron Science Center's Weapons Neutron Research facility provided neutrons in the energy range from 1 to 250 MeV. The time-of-flight technique was used to determine the incident-neutron energies. Results: Absolute partial cross sections for production of seven discrete Fe γ rays populated in 60Ni (n ,α /2 p x n γ ) reactions with 2 ≤x ≤5 were measured for neutron energies 1 MeV2 p 2 n and 2 p 3 n emission at higher incident energies in the nuclear charge region around Fe.

  20. K-shell auger decay of atomic oxygen

    SciTech Connect

    Stolte, W.C.; Lu, Y.; Samson, J.A.R.

    1997-04-01

    The aim of the present research is to understand the interaction between the ejected photoelectron and Auger electron produced by the Auger decay of a 1s hole in atomic oxygen, and to understand the influence this interaction has on the shape of the ionization cross sections. To accomplish this the authors have measured the relative ion yields (ion/photon) in the vicinity of the oxygen K-shell (525 - 533 eV) for O{sup +} and O{sup 2+}. The measurements were performed at the ALS on beamline, 6.3.2. The atomic oxygen was produced by passing molecular oxygen through a microwave-driven discharge. A Rydberg analysis of the two series leading to the [1s]2s{sup 2}2p{sup 4}({sup 4}P) and [1s]2s{sup 2}2p{sup 4}({sup 2}P) limits were obtained. This analysis shows some differences to the recently published results by Menzel et al. The energy position of the main 1s{sup 1}2s{sup 2}2p{sup 5}({sup 3}P) resonance differs by approximately 1 eV from the authors value, all members of the ({sup 2}P)np series differ by 0.3 eV, but the members of the ({sup 4}P)np series agree. The molecular resonance at 530.5 eV and those between 539 eV and 543 eV, measured with the microwave discharge off show identical results in both experiments.

  1. Higgs Doublet Decay as the Origin of the Baryon Asymmetry.

    PubMed

    Hambye, Thomas; Teresi, Daniele

    2016-08-26

    We consider a question that curiously had not been properly considered thus far: in the standard seesaw model, what is the minimum value the mass of a right-handed (RH) neutrino must have for allowing successful leptogenesis via CP-violating decays? Answering this question requires us to take into account a number of thermal effects. We show that, for low RH neutrino masses, and thanks to these effects, leptogenesis turns out to proceed efficiently from the decay of the standard model scalar doublet components into a RH neutrino and a lepton. Such decays produce the asymmetry at low temperatures, slightly before sphaleron decoupling. If the RH neutrino has thermalized prior to producing the asymmetry, this mechanism turns out to lead to the bound m_{N}>2  GeV. If, instead, the RH neutrinos have not thermalized, leptogenesis from these decays is enhanced further and can be easily successful, even at lower scales. This Higgs-decay leptogenesis new mechanism works without requiring an interplay of flavor effects and/or cancellations of large Yukawa couplings in the neutrino mass matrix. Last but not least, such a scenario turns out to be testable, from direct production of the RH neutrino(s).

  2. Higgs Doublet Decay as the Origin of the Baryon Asymmetry.

    PubMed

    Hambye, Thomas; Teresi, Daniele

    2016-08-26

    We consider a question that curiously had not been properly considered thus far: in the standard seesaw model, what is the minimum value the mass of a right-handed (RH) neutrino must have for allowing successful leptogenesis via CP-violating decays? Answering this question requires us to take into account a number of thermal effects. We show that, for low RH neutrino masses, and thanks to these effects, leptogenesis turns out to proceed efficiently from the decay of the standard model scalar doublet components into a RH neutrino and a lepton. Such decays produce the asymmetry at low temperatures, slightly before sphaleron decoupling. If the RH neutrino has thermalized prior to producing the asymmetry, this mechanism turns out to lead to the bound m_{N}>2  GeV. If, instead, the RH neutrinos have not thermalized, leptogenesis from these decays is enhanced further and can be easily successful, even at lower scales. This Higgs-decay leptogenesis new mechanism works without requiring an interplay of flavor effects and/or cancellations of large Yukawa couplings in the neutrino mass matrix. Last but not least, such a scenario turns out to be testable, from direct production of the RH neutrino(s). PMID:27610845

  3. Investigation on Thermal-Induced Decay of Fiber Bragg Grating

    NASA Astrophysics Data System (ADS)

    Zhang, Peng; Ding, Pinyi; Liu, Li

    2015-06-01

    A fiber Bragg grating (FBG), with advantages such as high anti-interference ability, a simple structure, and multiplexing, is widely used as a core component in numerous applications to monitor adverse environments of high temperature and air pressure. When FBGs are exposed to these extreme conditions, especially high temperature, performance decay may occur, bringing serious impact on the stability and reliability of the instruments. Therefore, it is necessary to make a detailed analysis on the mechanism of the thermal-induced decay of a FBG. One commonly used theory is proposed by Erdogn, which is based on a power function and aging curve method. However, these empirical equations are limited in application because only one single type of FBG can be analyzed this way. This paper focuses on the mechanism of a FBG, and presents a detailed analysis on the theory of the thermal-induced decay of a FBG using the electron dipole mode. Theoretical relationships between reflectivity and time or temperature were obtained, and a corresponding thermal-induced decay testing system was designed. The experimental and theoretical reflectivity decline under different temperatures of and are plotted, and the curves of reduction derived from the theoretical model fit the experimental data well. Thus, this model can be applied to predict the performance decay of FBGs at high temperature.

  4. Higgs Doublet Decay as the Origin of the Baryon Asymmetry

    NASA Astrophysics Data System (ADS)

    Hambye, Thomas; Teresi, Daniele

    2016-08-01

    We consider a question that curiously had not been properly considered thus far: in the standard seesaw model, what is the minimum value the mass of a right-handed (RH) neutrino must have for allowing successful leptogenesis via C P -violating decays? Answering this question requires us to take into account a number of thermal effects. We show that, for low RH neutrino masses, and thanks to these effects, leptogenesis turns out to proceed efficiently from the decay of the standard model scalar doublet components into a RH neutrino and a lepton. Such decays produce the asymmetry at low temperatures, slightly before sphaleron decoupling. If the RH neutrino has thermalized prior to producing the asymmetry, this mechanism turns out to lead to the bound mN>2 GeV . If, instead, the RH neutrinos have not thermalized, leptogenesis from these decays is enhanced further and can be easily successful, even at lower scales. This Higgs-decay leptogenesis new mechanism works without requiring an interplay of flavor effects and/or cancellations of large Yukawa couplings in the neutrino mass matrix. Last but not least, such a scenario turns out to be testable, from direct production of the RH neutrino(s).

  5. Further improvement of the upper limit on the direct 3α decay from the Hoyle state in 12C.

    PubMed

    Itoh, M; Ando, S; Aoki, T; Arikawa, H; Ezure, S; Harada, K; Hayamizu, T; Inoue, T; Ishikawa, T; Kato, K; Kawamura, H; Sakemi, Y; Uchiyama, A

    2014-09-01

    The direct 3α decay branch from the 02+ state at Ex=7.65  MeV in 12C, which is known as the Hoyle state, is considered to affect the triple-α reaction rate strongly and to give crucial information on its structure. We have performed a high-precision measurement of the 3α decay from this state using the 12C(12C,3α)12C reaction at E12C=110  MeV. The branching ratio of the direct 3α decay was under the detection limit in the present experiment. By comparing with Monte Carlo simulations for three decay mechanisms as the sequential decay through the ground state of ^{8}Be, the direct decay with equal energies of three α particles, and the direct decay to the phase space uniformly, we have obtained the upper limit of 0.2% on the direct 3α decay.

  6. β-Decay Half-Lives of 110 Neutron-Rich Nuclei across the N=82 Shell Gap: Implications for the Mechanism and Universality of the Astrophysical r Process.

    PubMed

    Lorusso, G; Nishimura, S; Xu, Z Y; Jungclaus, A; Shimizu, Y; Simpson, G S; Söderström, P-A; Watanabe, H; Browne, F; Doornenbal, P; Gey, G; Jung, H S; Meyer, B; Sumikama, T; Taprogge, J; Vajta, Zs; Wu, J; Baba, H; Benzoni, G; Chae, K Y; Crespi, F C L; Fukuda, N; Gernhäuser, R; Inabe, N; Isobe, T; Kajino, T; Kameda, D; Kim, G D; Kim, Y-K; Kojouharov, I; Kondev, F G; Kubo, T; Kurz, N; Kwon, Y K; Lane, G J; Li, Z; Montaner-Pizá, A; Moschner, K; Naqvi, F; Niikura, M; Nishibata, H; Odahara, A; Orlandi, R; Patel, Z; Podolyák, Zs; Sakurai, H; Schaffner, H; Schury, P; Shibagaki, S; Steiger, K; Suzuki, H; Takeda, H; Wendt, A; Yagi, A; Yoshinaga, K

    2015-05-15

    The β-decay half-lives of 110 neutron-rich isotopes of the elements from _{37}Rb to _{50}Sn were measured at the Radioactive Isotope Beam Factory. The 40 new half-lives follow robust systematics and highlight the persistence of shell effects. The new data have direct implications for r-process calculations and reinforce the notion that the second (A≈130) and the rare-earth-element (A≈160) abundance peaks may result from the freeze-out of an (n,γ)⇄(γ,n) equilibrium. In such an equilibrium, the new half-lives are important factors determining the abundance of rare-earth elements, and allow for a more reliable discussion of the r process universality. It is anticipated that universality may not extend to the elements Sn, Sb, I, and Cs, making the detection of these elements in metal-poor stars of the utmost importance to determine the exact conditions of individual r-process events.

  7. β-Decay Half-Lives of 110 Neutron-Rich Nuclei across the N=82 Shell Gap: Implications for the Mechanism and Universality of the Astrophysical r Process.

    PubMed

    Lorusso, G; Nishimura, S; Xu, Z Y; Jungclaus, A; Shimizu, Y; Simpson, G S; Söderström, P-A; Watanabe, H; Browne, F; Doornenbal, P; Gey, G; Jung, H S; Meyer, B; Sumikama, T; Taprogge, J; Vajta, Zs; Wu, J; Baba, H; Benzoni, G; Chae, K Y; Crespi, F C L; Fukuda, N; Gernhäuser, R; Inabe, N; Isobe, T; Kajino, T; Kameda, D; Kim, G D; Kim, Y-K; Kojouharov, I; Kondev, F G; Kubo, T; Kurz, N; Kwon, Y K; Lane, G J; Li, Z; Montaner-Pizá, A; Moschner, K; Naqvi, F; Niikura, M; Nishibata, H; Odahara, A; Orlandi, R; Patel, Z; Podolyák, Zs; Sakurai, H; Schaffner, H; Schury, P; Shibagaki, S; Steiger, K; Suzuki, H; Takeda, H; Wendt, A; Yagi, A; Yoshinaga, K

    2015-05-15

    The β-decay half-lives of 110 neutron-rich isotopes of the elements from _{37}Rb to _{50}Sn were measured at the Radioactive Isotope Beam Factory. The 40 new half-lives follow robust systematics and highlight the persistence of shell effects. The new data have direct implications for r-process calculations and reinforce the notion that the second (A≈130) and the rare-earth-element (A≈160) abundance peaks may result from the freeze-out of an (n,γ)⇄(γ,n) equilibrium. In such an equilibrium, the new half-lives are important factors determining the abundance of rare-earth elements, and allow for a more reliable discussion of the r process universality. It is anticipated that universality may not extend to the elements Sn, Sb, I, and Cs, making the detection of these elements in metal-poor stars of the utmost importance to determine the exact conditions of individual r-process events. PMID:26024165

  8. Search for a strongly decaying neutral charmed pentaquark

    SciTech Connect

    Link, J.M.; Yager, P.M.; Anjos, J.C.; Bediaga, I.; Castromonte, C.; Machado, A.A.; Magnin, J.; Massafferri, A.; de Miranda, J.M.; Pepe, I.M.; Polycarpo, E.; dos Reis, A.C.; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sanchez-Hernandez, A.; Uribe, C.; Vazquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J.P.; /Colorado U. /Fermilab /Frascati /Guanajuato U. /Illinois U., Urbana /Indiana U. /Korea U. /Kyungpook Natl. U. /INFN, Milan /Milan U. /North Carolina U. /Pavia U. /INFN, Pavia /Rio de Janeiro, Pont. U. Catol. /Puerto Rico U., Mayaguez /South Carolina U. /Tennessee U. /Vanderbilt U. /Wisconsin U., Madison

    2005-06-01

    We present a search for a charmed pentaquark decaying strongly to D{sup (*)}-p. Finding no evidence for such a state, we set limits on the cross section times branching ratio relative to D*{sup -} and D{sup -} under particular assumptions about the production mechanism.

  9. Calculations of Cascade Decay Processes Using Rudimentary Probability Theory.

    ERIC Educational Resources Information Center

    Zivitz, Maury

    1979-01-01

    Presents a new derivation based on simple theorems of probability theory for the established system of equations describing successive decay transitions of quantum systems. It is indicated that this derivation that has a quantum-mechanical foundation might be more appealing to applied physicists than other derivations. (HM)

  10. The Long Decay Model of One-Dimensional Projectile Motion

    ERIC Educational Resources Information Center

    Lattery, Mark Joseph

    2008-01-01

    This article introduces a research study on student model formation and development in introductory mechanics. As a point of entry, I present a detailed analysis of the Long Decay Model of one-dimensional projectile motion. This model has been articulated by Galileo ("in De Motu") and by contemporary students. Implications for instruction are…

  11. CP violation and suppressed $B_s$ decays at CDF

    SciTech Connect

    Lewis, J.D.; /Fermilab

    2011-12-01

    The study of heavy-quark decays continues to have wide interest as a possible avenue for the discovery of physics beyond the standard model. With data samples as large as 6 fb{sup -1}, the CDF collaboration is exploring new channels that will extend the reach of measurements in probing the CKM mechanism of CP violation. Several new measurements are presented.

  12. Photoelectron recapture and reemission process associated with double Auger decay in Ar

    NASA Astrophysics Data System (ADS)

    Hikosaka, Y.; Mashiko, R.; Odagiri, T.; Adachi, J.; Tanaka, H.; Kosuge, T.; Ito, K.

    2016-06-01

    Multielectron coincidence spectroscopy has been performed for Ar at a photon energy of only 0.2 eV above the 2 p1 /2 threshold. It is revealed that a postcollision interaction induced by double Auger decay leads to photoelectron recapture, followed by reemission of the captured electron, where the recapture of the slow photoelectron forms the A r2 + Rydberg-excited states which subsequently undergo autoionization. The energy correlation of the emitted electrons discloses that both direct and cascade paths in the double Auger decay contribute to the photoelectron recapture.

  13. Heavy quark spectroscopy and decay

    SciTech Connect

    Schindler, R.H.

    1987-01-01

    The understanding of q anti q systems containing heavy, charmed, and bottom quarks has progressed rapidly in recent years, through steady improvements in experimental techniques for production and detection of their decays. These lectures are meant to be an experimentalist's review of the subject. In the first of two lectures, the existing data on the spectroscopy of the bound c anti c and b anti b systems will be discussed. Emphasis is placed on comparisons with the theoretical models. The second lecture covers the rapidly changing subject of the decays of heavy mesons (c anti q and b anti q), and their excited states. In combination, the spectroscopy and decays of heavy quarks are shown to provide interesting insights into both the strong and electroweak interactions of the heavy quarks. 103 refs., 39 figs.

  14. Decay of capillary wave turbulence.

    PubMed

    Deike, Luc; Berhanu, Michael; Falcon, Eric

    2012-06-01

    We report on the observation of freely decaying capillary wave turbulence on the surface of a fluid. The capillary wave turbulence spectrum decay is found to be self-similar in time with the same power law exponent as the one found in the stationary regime, in agreement with weak turbulence predictions. The amplitude of all Fourier modes are found to decrease exponentially with time at the same damping rate. The longest wavelengths involved in the system are shown to be damped by a viscous surface boundary layer. These long waves play the role of an energy source during the decay that sustains nonlinear interactions to keep capillary waves in a wave turbulent state.

  15. Decay of silicon mounds: scaling laws and description with continuum step parameters

    PubMed

    Ichimiya; Hayashi; Williams; Einstein; Uwaha; Watanabe

    2000-04-17

    The decay of mounds about a dozen layers high on the Si(111)-(7x7) surface has been measured quantitatively by scanning tunneling microscopy and compared with analytic predictions for the power-law dependence on time predicted for a step-mediated decay mechanism. Conformably, we find an exponent 1/4 associated with the (3D) decay of the mound height and exponent 1/3 associated with the (2D) decay of top-layer islands. Using parameters from a continuum step model, we capture the essence of the kinetics. Qualitative features distinguish these mounds from multilayer islands found on metals.

  16. Universal decay law in charged-particle emission and exotic cluster radioactivity.

    PubMed

    Qi, C; Xu, F R; Liotta, R J; Wyss, R

    2009-08-14

    A linear universal decay formula is presented starting from the microscopic mechanism of the charged-particle emission. It relates the half-lives of monopole radioactive decays with the Q values of the outgoing particles as well as the masses and charges of the nuclei involved in the decay. This relation is found to be a generalization of the Geiger-Nuttall law in alpha radioactivity and explains well all known cluster decays. Predictions on the most likely emissions of various clusters are presented.

  17. Phospholipid flippases Lem3p-Dnf1p and Lem3p-Dnf2p are involved in the sorting of the tryptophan permease Tat2p in yeast.

    PubMed

    Hachiro, Takeru; Yamamoto, Takaharu; Nakano, Kenji; Tanaka, Kazuma

    2013-02-01

    The type 4 P-type ATPases are flippases that generate phospholipid asymmetry in membranes. In budding yeast, heteromeric flippases, including Lem3p-Dnf1p and Lem3p-Dnf2p, translocate phospholipids to the cytoplasmic leaflet of membranes. Here, we report that Lem3p-Dnf1/2p are involved in transport of the tryptophan permease Tat2p to the plasma membrane. The lem3Δ mutant exhibited a tryptophan requirement due to the mislocalization of Tat2p to intracellular membranes. Tat2p was relocalized to the plasma membrane when trans-Golgi network (TGN)-to-endosome transport was inhibited. Inhibition of ubiquitination by mutations in ubiquitination machinery also rerouted Tat2p to the plasma membrane. Lem3p-Dnf1/2p are localized to endosomal/TGN membranes in addition to the plasma membrane. Endocytosis mutants, in which Lem3p-Dnf1/2p are sequestered to the plasma membrane, also exhibited the ubiquitination-dependent missorting of Tat2p. These results suggest that Tat2p is ubiquitinated at the TGN and missorted to the vacuolar pathway in the lem3Δ mutant. The NH(2)-terminal cytoplasmic region of Tat2p containing ubiquitination acceptor lysines interacted with liposomes containing acidic phospholipids, including phosphatidylserine. This interaction was abrogated by alanine substitution mutations in the basic amino acids downstream of the ubiquitination sites. Interestingly, a mutant Tat2p containing these substitutions was missorted in a ubiquitination-dependent manner. We propose the following model based on these results; Tat2p is not ubiquitinated when the NH(2)-terminal region is bound to membrane phospholipids, but if it dissociates from the membrane due to a low level of phosphatidylserine caused by perturbation of phospholipid asymmetry in the lem3Δ mutant, Tat2p is ubiquitinated and then transported from the TGN to the vacuole.

  18. Gas-to-cluster effects in S 2p-excited SF{sub 6}

    SciTech Connect

    Flesch, Roman; Serdaroglu, Ertugrul; Ruehl, Eckart; Brykalova, Xenia O.; Kan, Elena I.; Klyushina, Ekaterina S.; Krivosenko, Yuri S.; Pavlychev, Andrey A.

    2013-04-14

    High resolution X-ray spectroscopic studies on free SF{sub 6} molecules and SF{sub 6} clusters near the S 2p ionization thresholds are reported. Spectral changes occurring in clusters for the intense molecular-like S 2p{sub 1/2,3/2}{yields} 6a{sub 1g}-, 2t{sub 2g}-, and 4e{sub g}-resonances are examined in detail. Neither gas-to-cluster spectral shifts nor changes in peak shape are observed for the pre-edge 6a{sub 1g}-band. Significant changes in band shape and distinct gas-to-cluster shifts occur in the S 2p{sub 1/2,3/2}{yields} 2t{sub 2g}- and 4e{sub g}-transitions. These are found in the S 2p-ionization continua. The quasiatomic approach is used to assign the experimental results. It is shown that a convolution of asymmetric and symmetric contributions from Lorentzian and Gaussian line shapes allows us to model the spectral distribution of oscillator strength for the S 2p{sub 1/2,3/2}{yields} 2t{sub 2g}-, and 4e{sub g}-transitions. The asymmetry is due to trapping of the photoelectron within the finite size potential barrier. The Lorentzian contribution is found to be dominating in the line shape of the S 2p{yields} 2t{sub 2g}- and 4e{sub g}-bands. The spectroscopic parameters of the spin-orbit components of both the 2t{sub 2g}- and 4e{sub g}-bands are extracted and their gas-to-cluster changes are analyzed. The photoelectron trapping times in free and clustered SF{sub 6} molecules are determined. Specifically, it is shown that spectral changes in clusters reflected in core-to-valence-transitions are due to a superposition of the singly scattered photoelectron waves at the neighboring molecules with the primary and multiply scattered waves within the molecular cage.

  19. β decay of Na32

    NASA Astrophysics Data System (ADS)

    Mattoon, C. M.; Sarazin, F.; Hackman, G.; Cunningham, E. S.; Austin, R. A. E.; Ball, G. C.; Chakrawarthy, R. S.; Finlay, P.; Garrett, P. E.; Grinyer, G. F.; Hyland, B.; Koopmans, K. A.; Leslie, J. R.; Phillips, A. A.; Schumaker, M. A.; Scraggs, H. C.; Schwarzenberg, J.; Smith, M. B.; Svensson, C. E.; Waddington, J. C.; Walker, P. M.; Washbrook, B.; Zganjar, E.

    2007-01-01

    The β-decay of Na32 has been studied using β-γ coincidences. New transitions and levels are tentatively placed in the level scheme of Mg32 from an analysis of γ-γ and β-γ-γ coincidences. The observation of the indirect feeding of the 2321 keV state in Mg32 removes some restrictions previously placed on the spin assignment for this state. No evidence of a state at 2117 keV in Mg32 is found. Previously unobserved weak transitions up to 5.4 MeV were recorded but could not be placed in the decay scheme of Na32.

  20. Laser-Assisted Muon Decay

    SciTech Connect

    Liu Aihua; Li Shumin; Berakdar, Jamal

    2007-06-22

    We show theoretically that the muon lifetime can be changed dramatically by embedding the decaying muon in a strong linearly polarized laser field. Evaluating the S-matrix elements taking all electronic multiphoton processes into account we find that a CO{sub 2} laser with an electric field amplitude of 10{sup 6} V cm{sup -1} results in an order of magnitude shorter lifetime of the muon. We also analyze the dependencies of the decay rate on the laser frequency and intensity.

  1. Resonant Auger decay driving intermolecular Coulombic decay in molecular dimers

    NASA Astrophysics Data System (ADS)

    Trinter, F.; Schöffler, M. S.; Kim, H.-K.; Sturm, F. P.; Cole, K.; Neumann, N.; Vredenborg, A.; Williams, J.; Bocharova, I.; Guillemin, R.; Simon, M.; Belkacem, A.; Landers, A. L.; Weber, Th.; Schmidt-Böcking, H.; Dörner, R.; Jahnke, T.

    2014-01-01

    In 1997, it was predicted that an electronically excited atom or molecule placed in a loosely bound chemical system (such as a hydrogen-bonded or van-der-Waals-bonded cluster) could efficiently decay by transferring its excess energy to a neighbouring species that would then emit a low-energy electron. This intermolecular Coulombic decay (ICD) process has since been shown to be a common phenomenon, raising questions about its role in DNA damage induced by ionizing radiation, in which low-energy electrons are known to play an important part. It was recently suggested that ICD can be triggered efficiently and site-selectively by resonantly core-exciting a target atom, which then transforms through Auger decay into an ionic species with sufficiently high excitation energy to permit ICD to occur. Here we show experimentally that resonant Auger decay can indeed trigger ICD in dimers of both molecular nitrogen and carbon monoxide. By using ion and electron momentum spectroscopy to measure simultaneously the charged species created in the resonant-Auger-driven ICD cascade, we find that ICD occurs in less time than the 20femtoseconds it would take for individual molecules to undergo dissociation. Our experimental confirmation of this process and its efficiency may trigger renewed efforts to develop resonant X-ray excitation schemes for more localized and targeted cancer radiation therapy.

  2. Kinetics and Thermochemistry of Reversible Adduct Formation in the Reaction of Cl((sup 2)P(sub J)) with CS2

    NASA Technical Reports Server (NTRS)

    Nicovich, J. M.; Shackelford, C. J.; Wine, P. H.

    1997-01-01

    Reversible adduct formation in the reaction of Cl((sup 2)P(sub J)) with CS2 has been observed over the temperature range 193-258 K by use of time-resolved resonance fluorescence spectroscopy to follow the decay of pulsed-laser-generated Cl((sup 2)P(sub J)) into equilbrium with CS2Cl. Rate coefficients for CS2Cl formation and decomposition have been determined as a function of temperature and pressure; hence, the equilbrium constant has been determined as a function of temperature. A second-law analysis of the temperature dependence of Kp and heat capacity corrections calculated with use of an assumed CS2Cl structure yields the following thermodynamic parameters for the association reaction: Delta-H(sub 298) = -10.5 +/- 0.5 kcal/mol, Delta-H(sub 0) = -9.5 +/- 0.7 kcal/mol, Delta-S(sub 298) = -26.8 +/- 2.4 cal/mol.deg., and Delta-H(sub f,298)(CS2Cl) = 46.4 +/- 0.6 kcal/mol. The resonance fluorescence detection scheme has been adapted to allow detection of Cl((sup 2)P(sub J)) in the presence of large concentrations of O2, thus allowing the CS2Cl + Cl + O2 reaction to be investigated. We find that the rate coefficient for CS2Cl + O2 reaction via all channels that do not generate Cl((sup 2)P(sub J)) is less than 2.5 x 10(exp-16) cu cm/(molecule.s) at 293 K and 300-Torr total pressure and that the total rate coefficient is less than 2 x 10 (exp -15) cu cm/(molecule.s) at 230 K and 30-Torr total pressure. Evidence for reversible adduct formation in the reaction of Cl((sup 2)P(sub J)) with COS was sought but not observed, even at temperatures as low as 194 K.

  3. Decay Data Evaluation Project (DDEP): evaluation of the main 233Pa decay characteristics.

    PubMed

    Chechev, Valery P; Kuzmenko, Nikolay K

    2006-01-01

    The results of a decay data evaluation are presented for 233Pa (beta-) decay to nuclear levels in 233U. These evaluated data have been obtained within the Decay Data Evaluation Project using information published up to 2005.

  4. Decay Data Evaluation Project (DDEP): evaluation of the main 233Pa decay characteristics.

    PubMed

    Chechev, Valery P; Kuzmenko, Nikolay K

    2006-01-01

    The results of a decay data evaluation are presented for 233Pa (beta-) decay to nuclear levels in 233U. These evaluated data have been obtained within the Decay Data Evaluation Project using information published up to 2005. PMID:16574422

  5. Neutrinoless double-β decay and nuclear transition matrix elements

    SciTech Connect

    Rath, P. K.

    2015-10-28

    Within mechanisms involving the light Majorana neutrinos, squark-neutrino, Majorons, sterile neutrinos and heavy Majorana neutrino, nuclear transition matrix elements for the neutrinoless (β{sup −}β{sup −}){sub 0ν} decay of {sup 96}Zr, {sup 100}Mo, {sup 128,130}Te and {sup 150}Nd nuclei are calculated by employing the PHFB approach. Effects due to finite size of nucleons, higher order currents, short range correlations, and deformations of parent as well as daughter nuclei on the calculated matrix elements are estimated. Uncertainties in nuclear transition matrix elements within long-ranged mechanisms but for double Majoron accompanied (β{sup −}β{sup −}ϕϕ){sub 0ν} decay modes are 9%–15%. In the case of short ranged heavy Majorona neutrino exchange mechanism, the maximum uncertainty is about 35%. The maximum systematic error within the mechanism involving the exchange of light Majorana neutrino is about 46%.

  6. Investigations on the charmless decay modes of Zc(3900 ) and Zc(4025 )

    NASA Astrophysics Data System (ADS)

    Wu, Qi; Li, Gang; Shao, Fenglan; Wang, Ruiqin

    2016-07-01

    To date, the nature of Zc(3900 )/Zc(4025 ) is not clear. In this work, we propose to study the internal structure of Zc(3900 )/Zc(4025 ) by exploring the charmless decays. Compared to charmed decays, charmless decay channels may play a unique role since they request the annihilation of the heavy constituents. We calculate the decay width for Zc(3900 )/Zc(4025 )→V P , where P and V denote the pseudoscalar and light vector meson, respectively. Here, the Zc(3900 ) and Zc(4025 ) are the molecular states of D*D ¯ and D*D¯*. The decay process occurs through intermediate D D*/D*D* meson loops. Based on an effective Lagrangian, we obtain sizable predictions for the branching ratios, which are accessible in experiments. The experimental measurements in the future will not only shed light on the decay mechanism but will also lead to a deeper understanding of the mysterious structure of the Zc(3900 )/Zc(4025 ).

  7. Novel preparation of highly dispersed Ni2P embedded in carbon framework and its improved catalytic performance

    NASA Astrophysics Data System (ADS)

    Wang, Shan; Wang, Kang; Wang, Xitao

    2016-11-01

    Highly dispersed Ni2P embedded in carbon framework with different phosphidation temperature was prepared through carbonizing Ni-alginate gel and followed by phosphidation with PPh3 in liquid phase. The significant effects of phosphidation temperature on Ni2P particle size and catalytic properties for isobutane dehydrogenation to isobutene were investigated. The results showed that Ni2P catalyst derived from the Ni-alginate gel (Ni2P-ADC), consisting of Ni2P particles embedded in carbon walls, possessed smaller particle size and more active site compared with Ni2P catalyst supported on active carbon (Ni2P/AC) prepared by impregnation method. The Ni2P-ADC catalyst phosphorized at 578 K for 3 h exhibited the highest catalytic performance, with the corresponding selectivity of isobutene approaching 89% and conversion approaching 15% after reaction for 4.5 h at 833 K, whereas Ni2P/AC catalyst prepared by impregnation method displays a much lower catalytic activity. The improved catalytic performance of the Ni2P-ADC can be ascribed to the smaller and highly dispersed Ni2P particles incorporated into carbon framework resulting from Ni-alginate gel.

  8. Calculation of Computational Complexity for Radix-2 (p) Fast Fourier Transform Algorithms for Medical Signals.

    PubMed

    Amirfattahi, Rassoul

    2013-10-01

    Owing to its simplicity radix-2 is a popular algorithm to implement fast fourier transform. Radix-2(p) algorithms have the same order of computational complexity as higher radices algorithms, but still retain the simplicity of radix-2. By defining a new concept, twiddle factor template, in this paper, we propose a method for exact calculation of multiplicative complexity for radix-2(p) algorithms. The methodology is described for radix-2, radix-2 (2) and radix-2 (3) algorithms. Results show that radix-2 (2) and radix-2 (3) have significantly less computational complexity compared with radix-2. Another interesting result is that while the number of complex multiplications in radix-2 (3) algorithm is slightly more than radix-2 (2), the number of real multiplications for radix-2 (3) is less than radix-2 (2). This is because of the twiddle factors in the form of which need less number of real multiplications and are more frequent in radix-2 (3) algorithm.

  9. Kinetic Energy Distribution of H(2p) Atoms from Dissociative Excitation of H2

    NASA Technical Reports Server (NTRS)

    Ajello, Joseph M.; Ahmed, Syed M.; Kanik, Isik; Multari, Rosalie

    1995-01-01

    The kinetic energy distribution of H(2p) atoms resulting from electron impact dissociation of H2 has been measured for the first time with uv spectroscopy. A high resolution uv spectrometer was used for the measurement of the H Lyman-alpha emission line profiles at 20 and 100 eV electron impact energies. Analysis of the deconvolved 100 eV line profile reveals the existence of a narrow line peak and a broad pedestal base. Slow H(2p) atoms with peak energy near 80 meV produce the peak profile, which is nearly independent of impact energy. The wings of H Lyman-alpha arise from dissociative excitation of a series of doubly excited Q(sub 1) and Q(sub 2) states, which define the core orbitals. The fast atom energy distribution peaks at 4 eV.

  10. Optoelectronic devices based on MoTe2 p-n junction

    NASA Astrophysics Data System (ADS)

    Bie, Ya-Qing; Heuck, Mikkel; Furchi, Marco; Grosso, Gabriele; Zheng, Jiabao; Cao, Yuan; Navarro-Moratalla, Efren; Englund, Dirk; Jarillo-Herrero, Pablo

    2D transition metal dichalcogenides (2D-TMD), such as MoS2, have been verified with many remarkable physical properties, which include an indirect to direct band transition as a function of thickness and a valley dependent spin polarization. One of the 2D-TMD family members, 2H-MoTe2 has been shown to be a direct bandgap semiconductor as a monolayer and bilayer with a near infrared (NIR) bandgap of about 1.1eV. However, optoelectronic devices based on MoTe2 were so far not experimentally demonstrated. Here, we will present a high on-off ratio MoTe2 p-n junction enabled by a hexagonal boron nitride encapsulation technique. Our study of the MoTe2 p-n junction devices sheds light on designing efficient NIR optoelectronic devices such as photodetectors and energy harvesting cells and light emitters.

  11. PISA: Federated Search in P2P Networks with Uncooperative Peers

    NASA Astrophysics Data System (ADS)

    Ren, Zujie; Shou, Lidan; Chen, Gang; Chen, Chun; Bei, Yijun

    Recently, federated search in P2P networks has received much attention. Most of the previous work assumed a cooperative environment where each peer can actively participate in information publishing and distributed document indexing. However, little work has addressed the problem of incorporating uncooperative peers, which do not publish their own corpus statistics, into a network. This paper presents a P2P-based federated search framework called PISA which incorporates uncooperative peers as well as the normal ones. In order to address the indexing needs for uncooperative peers, we propose a novel heuristic query-based sampling approach which can obtain high-quality resource descriptions from uncooperative peers at relatively low communication cost. We also propose an effective method called RISE to merge the results returned by uncooperative peers. Our experimental results indicate that PISA can provide quality search results, while utilizing the uncooperative peers at a low cost.

  12. Photoionization from the 5p {sup 2}P{sub 3/2} state of rubidium

    SciTech Connect

    Nadeem, Ali; Haq, S. U.

    2011-06-15

    We report two-step photoionization studies from the 5p {sup 2}P{sub 3/2} excited state of rubidium using two dye lasers simultaneously pumped by a common Nd:YAG laser in conjunction with a thermionic diode ion detector. The photoionization cross section at the first ionization threshold is measured as 18.8 {+-} 3 Mb and at excess energies of 0.013, 0.106, 0.229, and 0.329 eV is measured as 15, 13.6, 12.6, and 12.5 Mb, respectively. The measured value of the photoionization cross section at the threshold is used to calibrate the oscillator strengths of the 5p {sup 2}P{sub 3/2}{yields}nd {sup 2}D{sub 5/2} (22 {<=}n{<=} 52) Rydberg transitions.

  13. Hemi bonds and noncovalent interactions in the cational systems (XH2P: SHY)+

    NASA Astrophysics Data System (ADS)

    Li, Xiang; Li, An Yong

    2016-08-01

    Quantum chemistry ab initio MP2 and CCSD calculations were performed to investigate the P⋯S hemi bonds and noncovalent interactions in the radical cational systems (H3P:SH2)+, (FH2P:SH2)+ and (H3P:SHF)+. The hydride dimer (H3P:SH2)+ has a P⋯S hemi bonding structure and a H-bonding structure, (FH2P:SH2)+ has two hemi bonding structures and a proton-transferred H-bonding structure, (H3P:SHF)+ has two hemi bonding structures and three noncovalent structures. It is remarkable that these hemi bonds also have characters of pnicogen and chalcogen bonds. The binding energy, stability and bonding nature of the hemi bonds were presented.

  14. A study of the physical properties of single crystalline Fe5B2P

    NASA Astrophysics Data System (ADS)

    Lamichhane, Tej N.; Taufour, Valentin; Thimmaiah, Srinivasa; Parker, David S.; Bud'ko, Sergey L.; Canfield, Paul C.

    2016-03-01

    Single crystals of Fe5B2P were grown by self-flux growth technique. Structural and electrical and magnetic anisotropic properties are studied. The Curie temperature of Fe5B2P is determined to be 655±2 K. The saturation magnetization is determined to be 1.72 μB/Fe at 2 K. The temperature variation of the anisotropy constant K1 is determined for the first time, reaching ∼ 0.50 MJ/m3 at 2 K, and it is comparable to that of hard ferrites. The saturation magnetization is found to be larger than the hard ferrites. The first principle calculations of saturation magnetization and anisotropy constant are found to be consistent with the experimental results.

  15. Power-law photoluminescence decay in quantum dots

    SciTech Connect

    Král, Karel; Menšík, Miroslav

    2014-05-15

    Some quantum dot samples show a long-time (power-law) behavior of their luminescence intensity decay. This effect has been recently explained as being due to a cooperation of many tunneling channels transferring electrons from small quantum dots with triplet exciton to quantum dots at which the electrons can recombine with the holes in the valence band states. In this work we show that the long-time character of the sample luminescence decay can also be caused by an intrinsic property of a single dot, namely, by a non-adiabatic effect of the electron occupation up-conversion caused by the electron-phonon multiple scattering mechanism.

  16. Gravitino decay and the cosmic gamma-ray background

    NASA Technical Reports Server (NTRS)

    Stecker, F. W.

    1986-01-01

    It is argued that the cosmic gamma-ray background (CGB) spectrum does not exhibit evidence for the decay of light gravitinos, in contradiction to the suggestion by Olive and Silk (1985), who observed a bump near 1 MeV in the CGB radiation spectrum. It is suggested that better fits to the CGB spectrum would be provided by mechanisms generating a power-law spectrum which is flattened below about 2 MeV. Olive and Silk maintain that the decays of a long-lived particle such as the gravitino may be responsible for features in the gamma-ray spectrum near 1 MeV.

  17. Reliable measurement of the Li-like {sub 22}{sup 48}Ti 1s2s2p {sup 4}P{sub 5/2}{sup o} level lifetime by beam-foil and beam-two-foil experiments

    SciTech Connect

    Nandi, T.; Ahmad, Nissar; Wani, A. A.; Marketos, P.

    2006-03-15

    We have determined the lifetime of the Li-like {sub 22}{sup 48}Ti 1s2s2p {sup 4}P{sub 5/2}{sup o} level (210.5{+-}13.5 ps) using data from its x-ray decay channel through beam single- and two-foil experiments, coupled to a multicomponent iterative growth and decay analysis. Theoretical lifetime estimates for this zero-nuclear-spin ion lies within the uncertainty range of our experimental results, indicating that blending contributions to this level from the He-like 1s2p {sup 3}P{sub 2}{sup o} and 1s2s {sup 3}S{sub 1} levels are eliminated within the current approach. A previously reported discrepancy between experimental and theoretical 1s2s2p {sup 4}P{sub 5/2}{sup o} level lifetimes in {sub 23}{sup 51}V may, as a result, be attributed to hyperfine quenching.

  18. Fragmentation of methyl chloride photoexcited near Cl (2p) by mass spectrometry

    NASA Astrophysics Data System (ADS)

    Thissen, Roland; Simon, Marc; Hubin-Franskin, M.-J.

    1994-11-01

    The evolution of the fragmentation pathways of the methylchloride around the Cl 2p edge has been studied by use of charge separation mass spectrometry. Some fragmentation patterns are discussed in the frame of rapid fragmentation of the neutral and dissociation pathways characteristic of singly or multiply charged species. The correlation of the evolution of the charge separation spectra with the initial excitation process is used to give a definitive attribution to the pre-edge features present in the absorption spectrum.

  19. Lamb shift in the hydrogen atom: Lifetime of the 2p{1/2}level

    SciTech Connect

    Karshenboim, S.G.

    1995-05-01

    Corrections of order {alpha}(Z{alpha}){sup 2} to the width of the 2p{1/2} level in the hydrogen atom are considered in the logarithmic approximation. The ratio of this width to the splitting of n=2 states can be measured to high accuracy. With the aid of the experimental data available for this ratio, the new value for the Lamb splitting is found to be 1057.8576(21) MHz. 17 refs.

  20. Spin- and angle-resolved spectroscopy of S 2p photoionization in the hydrogen sulfide molecule

    SciTech Connect

    Turri, G.; Snell, G.; Canton, S.E.; Bilodeau, R.C.; Langer, B.; Martins, M.; Kukk, E.; Cherepkov, N.; Bozek, J.D.; Kilcoyne, A.L.; Berrah, N.

    2004-08-01

    Angle- and spin-resolved photoelectron spectroscopy with circularly and linearly polarized synchrotron radiation were used to study the electronic structure of the hydrogen sulfide molecule. A strong effect of the molecular environment appears in the spin-resolved measurements and, although less clearly, in the angular distribution of the sulfur 2p photoelectrons. The anisotropy and spin parameters of the three main spectral components have been obtained. The validity of simple atomic models in explaining the results is discussed.

  1. α and 2p2n emission in fast neutron-induced reactions on Ni60

    DOE PAGES

    Fotiades, N.; Devlin, M.; Haight, R. C.; Nelson, R. O.; Kunieda, S.; Kawano, T.

    2015-06-19

    The cross sections for populating the residual nucleus in the reaction AZX(n,x)A-4Z-2Y exhibit peaks as a function of incident neutron energy corresponding to the (n,n'α) reaction and, at higher energy, to the (n,2p3n) reaction. In addition, the relative magnitudes of these peaks vary with the Z of the target nucleus.

  2. Production and Identification of Wheat-Agropyron cristatum 2P Translocation Lines.

    PubMed

    Li, Huanhuan; Lv, Mingjie; Song, Liqiang; Zhang, Jinpeng; Gao, Ainong; Li, Lihui; Liu, Weihua

    2016-01-01

    Agropyron cristatum (L.) Gaertn. (2n = 28, PPPP), a wild relative of common wheat, possesses many potentially valuable traits that can be transferred to common wheat through breeding programs. The wheat-A. cristatum disomic addition and translocation lines can be used as bridge materials to introduce alien chromosomal segments to wheat. Wheat-A. cristatum 2P disomic addition line II-9-3 was highly resistant to powdery mildew and leaf rust, which was reported in our previous study. However, some translocation lines induced from II-9-3 have not been reported. In this study, some translocation lines were induced from II-9-3 by 60Co-γ irradiation and gametocidal chromosome 2C and then identified by cytological methods. Forty-nine wheat-A. cristatum translocation lines were obtained and various translcoation types were identified by GISH (genomic in situ hybridization), such as whole-arm, segmental and intercalary translocations. Dual-color FISH (fluorescent in situ hybridization) was applied to identify the wheat chromosomes involved in the translocations, and the results showed that A. cristatum 2P chromosome segments were translocated to the different wheat chromosomes, including 1A, 2A, 3A, 4A, 5A, 6A, 7A, 3B, 5B, 7B, 1D, 4D and 6D. Many different types of wheat-A. cristatum alien translocation lines would be valuable for not only identifying and cloning A. cristatum 2P-related genes and understanding the genetics and breeding effects of the translocation between A. cristatum chromosome 2P and wheat chromosomes, but also providing new germplasm resources for the wheat genetic improvement. PMID:26731742

  3. Production and Identification of Wheat-Agropyron cristatum 2P Translocation Lines

    PubMed Central

    Li, Huanhuan; Lv, Mingjie; Song, Liqiang; Zhang, Jinpeng; Gao, Ainong; Li, Lihui; Liu, Weihua

    2016-01-01

    Agropyron cristatum (L.) Gaertn. (2n = 28, PPPP), a wild relative of common wheat, possesses many potentially valuable traits that can be transferred to common wheat through breeding programs. The wheat-A. cristatum disomic addition and translocation lines can be used as bridge materials to introduce alien chromosomal segments to wheat. Wheat-A. cristatum 2P disomic addition line II-9-3 was highly resistant to powdery mildew and leaf rust, which was reported in our previous study. However, some translocation lines induced from II-9-3 have not been reported. In this study, some translocation lines were induced from II-9-3 by 60Co-γ irradiation and gametocidal chromosome 2C and then identified by cytological methods. Forty-nine wheat-A. cristatum translocation lines were obtained and various translcoation types were identified by GISH (genomic in situ hybridization), such as whole-arm, segmental and intercalary translocations. Dual-color FISH (fluorescent in situ hybridization) was applied to identify the wheat chromosomes involved in the translocations, and the results showed that A. cristatum 2P chromosome segments were translocated to the different wheat chromosomes, including 1A, 2A, 3A, 4A, 5A, 6A, 7A, 3B, 5B, 7B, 1D, 4D and 6D. Many different types of wheat-A. cristatum alien translocation lines would be valuable for not only identifying and cloning A. cristatum 2P-related genes and understanding the genetics and breeding effects of the translocation between A. cristatum chromosome 2P and wheat chromosomes, but also providing new germplasm resources for the wheat genetic improvement. PMID:26731742

  4. Elastic, magnetic and electronic properties of iridium phosphide Ir2P.

    PubMed

    Wang, Pei; Wang, Yonggang; Wang, Liping; Zhang, Xinyu; Yu, Xiaohui; Zhu, Jinlong; Wang, Shanmin; Qin, Jiaqian; Leinenweber, Kurt; Chen, Haihua; He, Duanwei; Zhao, Yusheng

    2016-01-01

    Cubic (space group: Fmm) iridium phosphide, Ir2P, has been synthesized at high pressure and high temperature. Angle-dispersive synchrotron X-ray diffraction measurements on Ir2P powder using a diamond-anvil cell at room temperature and high pressures (up to 40.6 GPa) yielded a bulk modulus of B0 = 306(6) GPa and its pressure derivative B0' = 6.4(5). Such a high bulk modulus attributed to the short and strongly covalent Ir-P bonds as revealed by first - principles calculations and three-dimensionally distributed [IrP4] tetrahedron network. Indentation testing on a well-sintered polycrystalline sample yielded the hardness of 11.8(4) GPa. Relatively low shear modulus of ~64 GPa from theoretical calculations suggests a complicated overall bonding in Ir2P with metallic, ionic, and covalent characteristics. In addition, a spin glass behavior is indicated by magnetic susceptibility measurements. PMID:26905444

  5. Elastic, magnetic and electronic properties of iridium phosphide Ir2P

    DOE PAGES

    Wang, Pei; Wang, Yonggang; Wang, Liping; Zhang, Xinyu; Yu, Xiaohui; Zhu, Jinlong; Wang, Shanmin; Qin, Jiaqian; Leinenweber, Kurt; Chen, Haihua; et al

    2016-02-24

    Cubic (space group: Fm3¯m) iridium phosphide, Ir2P, has been synthesized at high pressure and high temperature. Angle-dispersive synchrotron X-ray diffraction measurements on Ir2P powder using a diamond-anvil cell at room temperature and high pressures (up to 40.6 GPa) yielded a bulk modulus of B0 = 306(6) GPa and its pressure derivative B0'= 6.4(5). Such a high bulk modulus attributed to the short and strongly covalent Ir-P bonds as revealed by first – principles calculations and three-dimensionally distributed [IrP4] tetrahedron network. Indentation testing on a well–sintered polycrystalline sample yielded the hardness of 11.8(4) GPa. Relatively low shear modulus of ~64 GPamore » from theoretical calculations suggests a complicated overall bonding in Ir2P with metallic, ionic, and covalent characteristics. Additionally, a spin glass behavior is indicated by magnetic susceptibility measurements.« less

  6. Fragrance material review on 2-(p-Menth-1-ene-10-yl) cyclopentanone.

    PubMed

    Scognamiglio, J; Jones, L; Letizia, C S; Api, A M

    2012-10-01

    A toxicologic and dermatologic review of 2-(p-Menth-1-ene-10-yl) cyclopentanone when used as a fragrance ingredient is presented. 2-(p-Menth-1-ene-10-yl) cyclopentanone is a member of the fragrance structural group ketones cyclopentanones and cyclopentenones. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-(p-Menth-1-ene-10-yl) cyclopentanone were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, repeated dose, and genotoxicity data. A safety assessment of the entire cyclopentanones and cyclopentenones will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all cyclopentanones and cyclopentenones in fragrances.

  7. Duplication 2p25 in a child with clinical features of CHARGE syndrome.

    PubMed

    Sperry, Ethan D; Schuette, Jane L; van Ravenswaaij-Arts, Conny M A; Green, Glenn E; Martin, Donna M

    2016-05-01

    CHARGE syndrome is a dominant disorder characterized by ocular colobomata, heart defects, choanal atresia, retardation of growth and development, genital hypoplasia, and ear abnormalities including deafness and vestibular disorders. The majority of individuals with CHARGE have pathogenic variants in the gene encoding CHD7, a chromatin remodeling protein. Here, we present a 15-year-old girl with clinical features of CHARGE syndrome and a de novo 6.5 Mb gain of genomic material at 2p25.3-p25.2. The duplicated region contained 24 genes, including the early and broadly expressed transcription factor gene SOX11. Analysis of 28 other patients with CHARGE showed no SOX11 copy number changes or pathogenic sequence variants. To our knowledge, this child's chromosomal abnormality is unique and represents the first co-occurrence of duplication 2p25 and clinical features of CHARGE syndrome. We compare our patient's phenotype to ten previously published patients with isolated terminal duplication 2p, and elaborate on the clinical diagnosis of CHARGE in the context of atypical genetic findings. PMID:26850571

  8. Reevaluation of the O(+)(2P) reaction rate coefficients derived from Atmosphere Explorer C observations

    NASA Technical Reports Server (NTRS)

    Chang, T.; Torr, D. G.; Richards, P. G.; Solomon, S. C.

    1993-01-01

    O(+)(2P) is an important species for studies of the ionosphere and thermosphere: its emission at 7320 A can be used as a diagnostic of the thermospheric atomic oxygen density. Unfortunately, there are no laboratory measurements of the O and N2 reaction rates which are needed to determine the major sinks of (O+)(2p). We have recalculated the O and N2 reaction rates for O(+) (2P) using recent improvements in the solar EUV flux, cross sections, and photoelectron fluxes. For the standard solar EUV flux, the new N2 reaction rate of 3.4 +/- 1.5 x 10 exp -10 cu cm/s is close to the value obtained by Rusch et al. (1977), but the new O reaction rate of 4.0 +/- 1.9 x 10 exp -10 cu cm/sec is about 8 times larger. These new reaction rates are derived using neutral densities, electron density, and solar EUV fluxes measured by Atmosphere Explorer C in 1974 during solar minimum. The new theoretical emission rates are in good agreement with the data for the two orbits studied by Rusch et al.

  9. Elastic, magnetic and electronic properties of iridium phosphide Ir2P

    PubMed Central

    Wang, Pei; Wang, Yonggang; Wang, Liping; Zhang, Xinyu; Yu, Xiaohui; Zhu, Jinlong; Wang, Shanmin; Qin, Jiaqian; Leinenweber, Kurt; Chen, Haihua; He, Duanwei; Zhao, Yusheng

    2016-01-01

    Cubic (space group: Fmm) iridium phosphide, Ir2P, has been synthesized at high pressure and high temperature. Angle-dispersive synchrotron X-ray diffraction measurements on Ir2P powder using a diamond-anvil cell at room temperature and high pressures (up to 40.6 GPa) yielded a bulk modulus of B0 = 306(6) GPa and its pressure derivative B0′ = 6.4(5). Such a high bulk modulus attributed to the short and strongly covalent Ir-P bonds as revealed by first – principles calculations and three-dimensionally distributed [IrP4] tetrahedron network. Indentation testing on a well–sintered polycrystalline sample yielded the hardness of 11.8(4) GPa. Relatively low shear modulus of ~64 GPa from theoretical calculations suggests a complicated overall bonding in Ir2P with metallic, ionic, and covalent characteristics. In addition, a spin glass behavior is indicated by magnetic susceptibility measurements. PMID:26905444

  10. A cooperated P2P GIS for loose coupled governmental application

    NASA Astrophysics Data System (ADS)

    Li, Chenyu; Xie, Kunqing; Ma, Xiujun; Cai, Cuo; Sun, Yanfeng

    2007-06-01

    Current governmental applications are of large scale and always compute-intensive and data-intensive, and we focus on introducing P2P computing to facilitate loose coupled governmental applications in this paper. As GIS data is always deposited in locationally distributed nodes, which are probably administrated under spatial databases, the global range is divided into regions to eliminate complicated consistency maintenance and unnecessary message exchanging, and hierarchical spatial indexes are designed for efficient locating spatial resources and low control cost. When executing, a user submitted global spatial query are firstly parsed to sequential subtasks refer to distributed spatial index, and then dynamically passed to appropriate nodes and cooperatively accomplished. Nodes intercommunicate by cooperating messages, which are sent directly to the destination. Besides collaboration process of sequential execution, a dynamic alternative participant approach for failure handling of the sequential execution is provided, which saves the expensive rollback or abort. And this paper also designed and implemented a p2p based loose governmental application prototype, in which nodes intercommunicate via p2p network sub layer, also a user interface is implemented to manage the request from user and eventually reply a result.

  11. Introns Regulate Gene Expression in Cryptococcus neoformans in a Pab2p Dependent Pathway

    PubMed Central

    Goebels, Carolin; Thonn, Aline; Gonzalez-Hilarion, Sara; Rolland, Olga; Moyrand, Frederique; Beilharz, Traude H.; Janbon, Guilhem

    2013-01-01

    Most Cryptococccus neoformans genes are interrupted by introns, and alternative splicing occurs very often. In this study, we examined the influence of introns on C. neoformans gene expression. For most tested genes, elimination of introns greatly reduces mRNA accumulation. Strikingly, the number and the position of introns modulate the gene expression level in a cumulative manner. A screen for mutant strains able to express functionally an intronless allele revealed that the nuclear poly(A) binding protein Pab2 modulates intron-dependent regulation of gene expression in C. neoformans. PAB2 deletion partially restored accumulation of intronless mRNA. In addition, our results demonstrated that the essential nucleases Rrp44p and Xrn2p are implicated in the degradation of mRNA transcribed from an intronless allele in C. neoformans. Double mutant constructions and over-expression experiments suggested that Pab2p and Xrn2p could act in the same pathway whereas Rrp44p appears to act independently. Finally, deletion of the RRP6 or the CID14 gene, encoding the nuclear exosome nuclease and the TRAMP complex associated poly(A) polymerase, respectively, has no effect on intronless allele expression. PMID:23966870

  12. Autoionization study of the Argon 2p satellites excited near the argon 2s threshold

    SciTech Connect

    Wang, H.; Glans, P.; Hemmers, O.

    1997-04-01

    The dynamics of near-threshold photoionization is a complex phenomenon in which the many-electron character of the wavefunctions plays an important role. According to generalized time-independent resonant scattering theory, the transition matrix element from an initial state to a final state is the summation of the amplitudes of direct photoionization and an indirect term in which intermediate states are involved and the resonant behavior is embedded. Studies of the interference effects of intermediate states have been explored in the cases where the direct term is negligible. In the present work, electron time-of-flight spectra of the Ar 2p satellites were measured at two angles (magic and 0{degrees}) in the dipole plane with the exciting photon energy tuned in the vicinity of the Ar 2s threshold. For excitation far below or above the 2s threshold, the 2p satellites spectrum is dominated by 3p to np shakeup contributions upon the ionization of a 2p electron.

  13. Elastic, magnetic and electronic properties of iridium phosphide Ir2P.

    PubMed

    Wang, Pei; Wang, Yonggang; Wang, Liping; Zhang, Xinyu; Yu, Xiaohui; Zhu, Jinlong; Wang, Shanmin; Qin, Jiaqian; Leinenweber, Kurt; Chen, Haihua; He, Duanwei; Zhao, Yusheng

    2016-02-24

    Cubic (space group: Fmm) iridium phosphide, Ir2P, has been synthesized at high pressure and high temperature. Angle-dispersive synchrotron X-ray diffraction measurements on Ir2P powder using a diamond-anvil cell at room temperature and high pressures (up to 40.6 GPa) yielded a bulk modulus of B0 = 306(6) GPa and its pressure derivative B0' = 6.4(5). Such a high bulk modulus attributed to the short and strongly covalent Ir-P bonds as revealed by first - principles calculations and three-dimensionally distributed [IrP4] tetrahedron network. Indentation testing on a well-sintered polycrystalline sample yielded the hardness of 11.8(4) GPa. Relatively low shear modulus of ~64 GPa from theoretical calculations suggests a complicated overall bonding in Ir2P with metallic, ionic, and covalent characteristics. In addition, a spin glass behavior is indicated by magnetic susceptibility measurements.

  14. 8-Triazolylpurines: Towards Fluorescent Inhibitors of the MDM2/p53 Interaction.

    PubMed

    Pettersson, Mariell; Bliman, David; Jacobsson, Jimmy; Nilsson, Jesper R; Min, Jaeki; Iconaru, Luigi; Guy, R Kiplin; Kriwacki, Richard W; Andréasson, Joakim; Grøtli, Morten

    2015-01-01

    Small molecule nonpeptidic mimics of α-helices are widely recognised as protein-protein interaction (PPIs) inhibitors. Protein-protein interactions mediate virtually all important regulatory pathways in a cell, and the ability to control and modulate PPIs is therefore of great significance to basic biology, where controlled disruption of protein networks is key to understanding network connectivity and function. We have designed and synthesised two series of 2,6,9-substituted 8-triazolylpurines as α-helix mimetics. The first series was designed based on low energy conformations but did not display any biological activity in a biochemical fluorescence polarisation assay targeting MDM2/p53. Although solution NMR conformation studies demonstrated that such molecules could mimic the topography of an α-helix, docking studies indicated that the same compounds were not optimal as inhibitors for the MDM2/p53 interaction. A new series of 8-triazolylpurines was designed based on a combination of docking studies and analysis of recently published inhibitors. The best compound displayed low micromolar inhibitory activity towards MDM2/p53 in a biochemical fluorescence polarisation assay. In order to evaluate the applicability of these compounds as biologically active and intrinsically fluorescent probes, their absorption/emission properties were measured. The compounds display fluorescent properties with quantum yields up to 50%.

  15. Multiple photon emission in heavy particle decays

    NASA Technical Reports Server (NTRS)

    Asakimori, K.; Burnett, T. H.; Cherry, M. L.; Christl, M. J.; Dake, S.; Derrickson, J. H.; Fountain, W. F.; Fuki, M.; Gregory, J. C.; Hayashi, T.

    1994-01-01

    Cosmic ray interactions, at energies above 1 TeV/nucleon, in emulsion chambers flown on high altitude balloons have yielded two events showing apparent decays of a heavy particle into one charged particle and four photons. The photons converted into electron pairs very close to the decay vertex. Attempts to explain this decay topology with known particle decays are presented. Unless both events represent a b yields u transition, which is statistically unlikely, then other known decay modes for charmed or bottom particles do not account satisfactorily for these observations. This could indicate, possibly, a new decay channel.

  16. CP violation and rare decays

    SciTech Connect

    Quigg, C.

    2000-01-24

    After a brief essay on the current state of particle physics and possible approaches to the opportunities that have presented themselves, the author summarizes the contributions to the Third Workshop on Physics and Detectors for DA{Phi}NE that deal with CP Violation and Rare Decays.

  17. Rare decays at the Tevatron

    SciTech Connect

    Farrington, S.M.; /Liverpool U.

    2006-01-01

    The confidence level limits of the CDF and D0 searches for the B{sub s}{sup 0}, B{sub d}{sup 0} {yields} {mu}{sup +}{mu}{sup -} and B{sub s}{sup 0} {yields} {mu}{sup +}{mu}{sup -}{phi} rare decays are presented.

  18. First observation of the decay

    NASA Astrophysics Data System (ADS)

    Aaij, R.; Abellan Beteta, C.; Adeva, B.; Adinolfi, M.; Adrover, C.; Affolder, A.; Ajaltouni, Z.; Albrecht, J.; Alessio, F.; Alexander, M.; Ali, S.; Alkhazov, G.; Alvarez Cartelle, P.; Alves, A. A.; Amato, S.; Amerio, S.; Amhis, Y.; Anderlini, L.; Anderson, J.; Andreassen, R.; Appleby, R. B.; Aquines Gutierrez, O.; Archilli, F.; Artamonov, A.; Artuso, M.; Aslanides, E.; Auriemma, G.; Bachmann, S.; Back, J. J.; Baesso, C.; Balagura, V.; Baldini, W.; Barlow, R. J.; Barschel, C.; Barsuk, S.; Barter, W.; Bauer, Th.; Bay, A.; Beddow, J.; Bedeschi, F.; Bediaga, I.; Belogurov, S.; Belous, K.; Belyaev, I.; Ben-Haim, E.; Benayoun, M.; Bencivenni, G.; Benson, S.; Benton, J.; Berezhnoy, A.; Bernet, R.; Bettler, M.-O.; van Beuzekom, M.; Bien, A.; Bifani, S.; Bird, T.; Bizzeti, A.; Bjørnstad, P. M.; Blake, T.; Blanc, F.; Blouw, J.; Blusk, S.; Bocci, V.; Bondar, A.; Bondar, N.; Bonivento, W.; Borghi, S.; Borgia, A.; Bowcock, T. J. V.; Bowen, E.; Bozzi, C.; Brambach, T.; van den Brand, J.; Bressieux, J.; Brett, D.; Britsch, M.; Britton, T.; Brook, N. H.; Brown, H.; Burducea, I.; Bursche, A.; Busetto, G.; Buytaert, J.; Cadeddu, S.; Callot, O.; Calvi, M.; Calvo Gomez, M.; Camboni, A.; Campana, P.; Campora Perez, D.; Carbone, A.; Carboni, G.; Cardinale, R.; Cardini, A.; Carranza-Mejia, H.; Carson, L.; Carvalho Akiba, K.; Casse, G.; Castillo Garcia, L.; Cattaneo, M.; Cauet, Ch.; Charles, M.; Charpentier, Ph.; Chen, P.; Chiapolini, N.; Chrzaszcz, M.; Ciba, K.; Cid Vidal, X.; Ciezarek, G.; Clarke, P. E. L.; Clemencic, M.; Cliff, H. V.; Closier, J.; Coca, C.; Coco, V.; Cogan, J.; Cogneras, E.; Collins, P.; Comerma-Montells, A.; Contu, A.; Cook, A.; Coombes, M.; Coquereau, S.; Corti, G.; Couturier, B.; Cowan, G. A.; Craik, D. C.; Cunliffe, S.; Currie, R.; D'Ambrosio, C.; David, P.; David, P. N. Y.; Davis, A.; De Bonis, I.; De Bruyn, K.; De Capua, S.; De Cian, M.; De Miranda, J. M.; De Paula, L.; De Silva, W.; De Simone, P.; Decamp, D.; Deckenhoff, M.; Del Buono, L.; Derkach, D.; Deschamps, O.; Dettori, F.; Di Canto, A.; Dijkstra, H.; Dogaru, M.; Donleavy, S.; Dordei, F.; Dosil Suárez, A.; Dossett, D.; Dovbnya, A.; Dupertuis, F.; Dzhelyadin, R.; Dziurda, A.; Dzyuba, A.; Easo, S.; Egede, U.; Egorychev, V.; Eidelman, S.; van Eijk, D.; Eisenhardt, S.; Eitschberger, U.; Ekelhof, R.; Eklund, L.; El Rifai, I.; Elsasser, Ch.; Elsby, D.; Falabella, A.; Färber, C.; Fardell, G.; Farinelli, C.; Farry, S.; Fave, V.; Ferguson, D.; Fernandez Albor, V.; Ferreira Rodrigues, F.; Ferro-Luzzi, M.; Filippov, S.; Fiore, M.; Fitzpatrick, C.; Fontana, M.; Fontanelli, F.; Forty, R.; Francisco, O.; Frank, M.; Frei, C.; Frosini, M.; Furcas, S.; Furfaro, E.; Gallas Torreira, A.; Galli, D.; Gandelman, M.; Gandini, P.; Gao, Y.; Garofoli, J.; Garosi, P.; Garra Tico, J.; Garrido, L.; Gaspar, C.; Gauld, R.; Gersabeck, E.; Gersabeck, M.; Gershon, T.; Ghez, Ph.; Gibson, V.; Gligorov, V. V.; Göbel, C.; Golubkov, D.; Golutvin, A.; Gomes, A.; Gordon, H.; Grabalosa Gándara, M.; Graciani Diaz, R.; Granado Cardoso, L. A.; Graugés, E.; Graziani, G.; Grecu, A.; Greening, E.; Gregson, S.; Grünberg, O.; Gui, B.; Gushchin, E.; Guz, Yu.; Gys, T.; Hadjivasiliou, C.; Haefeli, G.; Haen, C.; Haines, S. C.; Hall, S.; Hampson, T.; Hansmann-Menzemer, S.; Harnew, N.; Harnew, S. T.; Harrison, J.; Hartmann, T.; He, J.; Heijne, V.; Hennessy, K.; Henrard, P.; Hernando Morata, J. A.; van Herwijnen, E.; Hicheur, A.; Hicks, E.; Hill, D.; Hoballah, M.; Holtrop, M.; Hombach, C.; Hopchev, P.; Hulsbergen, W.; Hunt, P.; Huse, T.; Hussain, N.; Hutchcroft, D.; Hynds, D.; Iakovenko, V.; Idzik, M.; Ilten, P.; Jacobsson, R.; Jaeger, A.; Jans, E.; Jaton, P.; Jing, F.; John, M.; Johnson, D.; Jones, C. R.; Joram, C.; Jost, B.; Kaballo, M.; Kandybei, S.; Karacson, M.; Karbach, T. M.; Kenyon, I. R.; Kerzel, U.; Ketel, T.; Keune, A.; Khanji, B.; Kochebina, O.; Komarov, I.; Koopman, R. F.; Koppenburg, P.; Korolev, M.; Kozlinskiy, A.; Kravchuk, L.; Kreplin, K.; Kreps, M.; Krocker, G.; Krokovny, P.; Kruse, F.; Kucharczyk, M.; Kudryavtsev, V.; Kvaratskheliya, T.; La Thi, V. N.; Lacarrere, D.; Lafferty, G.; Lai, A.; Lambert, D.; Lambert, R. W.; Lanciotti, E.; Lanfranchi, G.; Langenbruch, C.; Latham, T.; Lazzeroni, C.; Le Gac, R.; van Leerdam, J.; Lees, J.-P.; Lefèvre, R.; Leflat, A.; Lefrançois, J.; Leo, S.; Leroy, O.; Lesiak, T.; Leverington, B.; Li, Y.; Li Gioi, L.; Liles, M.; Lindner, R.; Linn, C.; Liu, B.; Liu, G.; Lohn, S.; Longstaff, I.; Lopes, J. H.; Lopez Asamar, E.; Lopez-March, N.; Lu, H.; Lucchesi, D.; Luisier, J.; Luo, H.; Machefert, F.; Machikhiliyan, I. V.; Maciuc, F.; Maev, O.; Malde, S.; Manca, G.; Mancinelli, G.; Marconi, U.; Märki, R.; Marks, J.; Martellotti, G.; Martens, A.; Martín Sánchez, A.; Martinelli, M.; Martinez Santos, D.; Martins Tostes, D.; Massafferri, A.; Matev, R.; Mathe, Z.; Matteuzzi, C.; Maurice, E.; Mazurov, A.; McCarthy, J.; McNab, A.; McNulty, R.; Meadows, B.; Meier, F.; Meissner, M.; Merk, M.; Milanes, D. A.; Minard, M.-N.; Molina Rodriguez, J.; Monteil, S.; Moran, D.; Morawski, P.; Morello, M. J.; Mountain, R.; Mous, I.; Muheim, F.; Müller, K.; Muresan, R.; Muryn, B.; Muster, B.; Naik, P.; Nakada, T.; Nandakumar, R.; Nasteva, I.; Needham, M.; Neufeld, N.; Nguyen, A. D.; Nguyen, T. D.; Nguyen-Mau, C.; Nicol, M.; Niess, V.; Niet, R.; Nikitin, N.; Nikodem, T.; Nomerotski, A.; Novoselov, A.; Oblakowska-Mucha, A.; Obraztsov, V.; Oggero, S.; Ogilvy, S.; Okhrimenko, O.; Oldeman, R.; Orlandea, M.; Otalora Goicochea, J. M.; Owen, P.; Oyanguren, A.; Pal, B. K.; Palano, A.; Palutan, M.; Panman, J.; Papanestis, A.; Pappagallo, M.; Parkes, C.; Parkinson, C. J.; Passaleva, G.; Patel, G. D.; Patel, M.; Patrick, G. N.; Patrignani, C.; Pavel-Nicorescu, C.; Pazos Alvarez, A.; Pellegrino, A.; Penso, G.; Pepe Altarelli, M.; Perazzini, S.; Perego, D. L.; Perez Trigo, E.; Pérez-Calero Yzquierdo, A.; Perret, P.; Perrin-Terrin, M.; Pessina, G.; Petridis, K.; Petrolini, A.; Phan, A.; Picatoste Olloqui, E.; Pietrzyk, B.; Pilař, T.; Pinci, D.; Playfer, S.; Plo Casasus, M.; Polci, F.; Polok, G.; Poluektov, A.; Polycarpo, E.; Popov, D.; Popovici, B.; Potterat, C.; Powell, A.; Prisciandaro, J.; Pritchard, A.; Prouve, C.; Pugatch, V.; Puig Navarro, A.; Punzi, G.; Qian, W.; Rademacker, J. H.; Rakotomiaramanana, B.; Rangel, M. S.; Raniuk, I.; Rauschmayr, N.; Raven, G.; Redford, S.; Reid, M. M.; dos Reis, A. C.; Ricciardi, S.; Richards, A.; Rinnert, K.; Rives Molina, V.; Roa Romero, D. A.; Robbe, P.; Rodrigues, E.; Rodriguez Perez, P.; Roiser, S.; Romanovsky, V.; Romero Vidal, A.; Rouvinet, J.; Ruf, T.; Ruffini, F.; Ruiz, H.; Ruiz Valls, P.; Sabatino, G.; Saborido Silva, J. J.; Sagidova, N.; Sail, P.; Saitta, B.; Salzmann, C.; Sanmartin Sedes, B.; Sannino, M.; Santacesaria, R.; Santamarina Rios, C.; Santovetti, E.; Sapunov, M.; Sarti, A.; Satriano, C.; Satta, A.; Savrie, M.; Savrina, D.; Schaack, P.; Schiller, M.; Schindler, H.; Schlupp, M.; Schmelling, M.; Schmidt, B.; Schneider, O.; Schopper, A.; Schune, M.-H.; Schwemmer, R.; Sciascia, B.; Sciubba, A.; Seco, M.; Semennikov, A.; Sepp, I.; Serra, N.; Serrano, J.; Seyfert, P.; Shapkin, M.; Shapoval, I.; Shatalov, P.; Shcheglov, Y.; Shears, T.; Shekhtman, L.; Shevchenko, O.; Shevchenko, V.; Shires, A.; Silva Coutinho, R.; Skwarnicki, T.; Smith, N. A.; Smith, E.; Smith, M.; Sokoloff, M. D.; Soler, F. J. P.; Soomro, F.; Souza, D.; De Paula, B. Souza; Spaan, B.; Sparkes, A.; Spradlin, P.; Stagni, F.; Stahl, S.; Steinkamp, O.; Stoica, S.; Stone, S.; Storaci, B.; Straticiuc, M.; Straumann, U.; Subbiah, V. K.; Swientek, S.; Syropoulos, V.; Szczekowski, M.; Szczypka, P.; Szumlak, T.; T'Jampens, S.; Teklishyn, M.; Teodorescu, E.; Teubert, F.; Thomas, C.; Thomas, E.; van Tilburg, J.; Tisserand, V.; Tobin, M.; Tolk, S.; Tonelli, D.; Topp-Joergensen, S.; Torr, N.; Tournefier, E.; Tourneur, S.; Tran, M. T.; Tresch, M.; Tsaregorodtsev, A.; Tsopelas, P.; Tuning, N.; Ubeda Garcia, M.; Ukleja, A.; Urner, D.; Uwer, U.; Vagnoni, V.; Valenti, G.; Vazquez Gomez, R.; Vazquez Regueiro, P.; Vecchi, S.; Velthuis, J. J.; Veltri, M.; Veneziano, G.; Vesterinen, M.; Viaud, B.; Vieira, D.; Vilasis-Cardona, X.; Vollhardt, A.; Volyanskyy, D.; Voong, D.; Vorobyev, A.; Vorobyev, V.; Voß, C.; Voss, H.; Waldi, R.; Wallace, R.; Wandernoth, S.; Wang, J.; Ward, D. R.; Watson, N. K.; Webber, A. D.; Websdale, D.; Whitehead, M.; Wicht, J.; Wiechczynski, J.; Wiedner, D.; Wiggers, L.; Wilkinson, G.; Williams, M. P.; Williams, M.; Wilson, F. F.; Wishahi, J.; Witek, M.; Wotton, S. A.; Wright, S.; Wu, S.; Wyllie, K.; Xie, Y.; Xing, Z.; Yang, Z.; Young, R.; Yuan, X.; Yushchenko, O.; Zangoli, M.; Zavertyaev, M.; Zhang, F.; Zhang, L.; Zhang, W. C.; Zhang, Y.; Zhelezov, A.; Zhokhov, A.; Zhong, L.; Zvyagin, A.

    2013-11-01

    The first observation of the decay is reported. The analysis is based on a data sample corresponding to an integrated luminosity of 1.0 fb-1 of pp collisions at TeV, collected with the LHCb detector. A yield of 30 ± 6 decays is found in the mass windows 1012.5 < M ( K + K -) < 1026.5 MeV/ c 2 and 746 < M( K - π +) < 1046 MeV/ c 2. The signal yield is found to be dominated by decays, and the corresponding branching fraction is measured to be = (1.10 ± 0.24 (stat) ± 0.14 (syst) ± 0.08 ( f d / f s )) × 10-6, where the uncertainties are statistical, systematic and from the ratio of fragmentation fractions f d / f s which accounts for the different production rate of B 0 and mesons. The significance of signal is 6.1 standard deviations. The fraction of longitudinal polarization in decays is found to be f 0 = 0.51 ± 0.15 (stat) ± 0.07 (syst). [Figure not available: see fulltext.

  19. Nuclear structure from radioactive decay

    SciTech Connect

    Wood, J.L.

    1990-09-30

    This report discusses the nuclear structure of the following isotopes as a result of radioactive decays: neutron-deficient iridium isotopes; neutron-deficient platinum isotopes; neutron-deficient gold isotopes; neutron-deficient mercury isotopes; neutron-deficient thallium isotopes; neutron-deficient lead isotopes; neutron-deficient promethium isotopes; and neutron-deficient samarium isotopes.

  20. Rare B decays at CDF

    SciTech Connect

    Farrington, Sinead M.; /Liverpool U.

    2006-10-01

    The confidence level limits of the CDF search for the B{sub s}{sup 0} and B{sub d}{sup 0} {yields} {mu}{sup +}{mu}{sup -} rare decays and the branching ratio measurement of B{sub s}{sup 0} {yields} D{sub s}{sup +} D{sub s}{sup -} are presented.

  1. Review of tau lepton decays

    SciTech Connect

    Stoker, D.P.

    1991-07-01

    Measurements of the {tau} decay modes are reviewed and compared with the predictions of the Standard Model. While the agreement is generally good, the status of the 1-prong puzzle'' remains controversial and a discrepancy between the measured leptonic branching fractions and the {tau} lifetime persists. Prospects for precision measurements at a Tau-Charm Factory are also reviewed. 20 refs., 2 tabs.

  2. Fermi's β-DECAY Theory

    NASA Astrophysics Data System (ADS)

    Yang, Chen Ning

    2013-05-01

    Throughout his lifetime Enrico Fermi (1901-1954) had considered his 1934 β-decay theory as his most important contribution to theoretical physics. E. Segrè (1905-1989) had vividly written about an episode at the inception of that paper:1...

  3. Image reconstruction from cryo-electron micrographs reveals the morphopoietic mechanism in the P2-P4 bacteriophage system.

    PubMed

    Dokland, T; Lindqvist, B H; Fuller, S D

    1992-03-01

    The satellite bacteriophage P4 does not have genes coding for any major structural proteins, but assembles a capsid from the gene products of bacteriophage P2. The capsid assembled under control of P4 is smaller (45 nm) than the normal P2 capsid (60 nm). The low resolution (4.5 nm) structures of P2 and P4 capsids were determined by cryo-electron microscopy and image processing. The capsid of P2 shows T = 7 symmetry with most of the mass clustered as 12 pentamers and 60 hexamers. The P4 capsid has T = 4 symmetry with a similar distribution of mass to P2, but the hexamer geometry has changed. The major capsid protein has a two-domain structure. The major domains form the capsomers proper, while connecting domains form trivalent contacts between the capsomers. The size determination by P4 appears to function by altering hexamer geometry rather than by affecting the interdomain angle alone.

  4. Charge dependence of solvent-mediated intermolecular Coster-Kronig decay dynamics of aqueous ions.

    PubMed

    Ohrwall, G; Ottosson, N; Pokapanich, W; Legendre, S; Svensson, S; Björneholm, O

    2010-12-30

    The 2s and 2p photoelectron spectra have been measured for Na(+), Mg(2+), and Al(3+) ions in aqueous solution. In all cases, the 2s lines are significantly broader than the 2p features, which is attributed to a shorter lifetime of the respective 2s hole. Since intraionic Coster-Kronig decay channels from the (2s)(-1) state are closed for free Na(+), Mg(2+), and Al(3+) ions, this is evidence for an intermolecular Coster-Kronig-like process, reminiscent of intermolecular Coulombic decay (ICD), involving neighboring water solvent molecules. The observed 2s Lorentzian line widths correspond to lifetimes of the (2s)(-1) state of 3.1, 1.5, and 0.98 fs for the solvated Na, Mg, and Al ions, respectively.

  5. Variant-specific and diminishing immune responses towards the highly variable MSP2(P44) outer membrane protein of Anaplasma phagocytophilum during persistent infection in lambs.

    PubMed

    Granquist, Erik G; Stuen, Snorre; Crosby, Liliana; Lundgren, Anna M; Alleman, A Rick; Barbet, Anthony F

    2010-02-15

    Anaplasma phagocytophilum is the causative agent of tick-borne fever in small ruminants and has been identified as the zoonotic agent of human granulocytic anaplasmosis. The Norwegian strains of the rickettsia are naturally persistent in lambs and represent a suitable experimental system for analyzing the mechanisms of persistence. Variation of the outer membrane protein MSP2(P44) by recombination of variable pseudogene segments into an expression site is believed to play a key role in persistence of the organism. The goal of the present study was to analyze the dynamics of the immune response towards A. phagocytophilum and MSP2(P44) during persistent infection of lambs. Responses to the hypervariable region of MSP2(P44) were detected shortly after appearance of the respective variants in cyclic rickettsemic peaks, consistent with a process of antigenic variation. In addition, there was a diminishing antibody response to MSP2(P44) and to other A. phagocytophilum antigens overall with time of infection, that was not associated with clearance of the infection.

  6. Bacteria Absorption-Based Mn2P2O7-Carbon@Reduced Graphene Oxides for High-Performance Lithium-Ion Battery Anodes.

    PubMed

    Yang, Yuhua; Wang, Bin; Zhu, Jingyi; Zhou, Jun; Xu, Zhi; Fan, Ling; Zhu, Jian; Podila, Ramakrishna; Rao, Apparao M; Lu, Bingan

    2016-05-24

    The development of freestanding flexible electrodes with high capacity and long cycle-life is a central issue for lithium-ion batteries (LIBs). Here, we use bacteria absorption of metallic Mn(2+) ions to in situ synthesize natural micro-yolk-shell-structure Mn2P2O7-carbon, followed by the use of vacuum filtration to obtain Mn2P2O7-carbon@reduced graphene oxides (RGO) papers for LIBs anodes. The Mn2P2O7 particles are completely encapsulated within the carbon film, which was obtained by carbonizing the bacterial wall. The resulting carbon microstructure reduces the electrode-electrolyte contact area, yielding high Coulombic efficiency. In addition, the yolk-shell structure with its internal void spaces is ideal for sustaining volume expansion of Mn2P2O7 during charge/discharge processes, and the carbon shells act as an ideal barrier, limiting most solid-electrolyte interphase formation on the surface of the carbon films (instead of forming on individual particles). Notably, the RGO films have high conductivity and robust mechanical flexibility. As a result of our combined strategies delineated in this article, our binder-free flexible anodes exhibit high capacities, long cycle-life, and excellent rate performance.

  7. FDCSUSYDecay: An MSSM decay package

    NASA Astrophysics Data System (ADS)

    Qi, Wei; Wang, Jian-xiong

    2007-08-01

    FDCSUSYDecay is a FORTRAN program package generated by FDC (Feynman Diagram Calculation) system fully automatically. It is dedicated to calculate at tree-level all the possible 2-body decays of SUSY and Higgs particles in the Minimal Supersymmetric extension of the Standard Model (MSSM). The format of its output files complies with SUSY Les Houches Accord and can be easily imported by other packages. Program summaryManuscript title:FDCSUSYDecay: An MSSM decay package Authors:Wei Qi, Jian-xiong Wang Program title:FDCSUSYDecay (Version 1.00) Catalogue identifier:ADYV_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADYV_v1_0.html Program obtainable from:CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions:Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.:22 008 No. of bytes in distributed program, including test data, etc.:622 751 Distribution format:tar.gz Programming language:FORTRAN 77 Operating system:Linux Keywords:SUSY decay, MSSM, FDC PACS:02.70.-c, 12.60.Jv Classification:11.1, 11.6 External routines:CERNLIB 2003 (or up) Nature of problem: This package can calculate all the possible SUSY particle and Higgs 2-body decay width and branch ratio at tree-level in the MSSM model. Solution method: By running FDC, the Feynman rules for the MSSM model are generated, all the decay widths are calculated analytically and corresponding FORTRAN codes are generated for this package. Running time: Less than 1 second for both high-scale and low-scale modes on a Pentium IV 2.4 GHz machine (512 MB memory).

  8. Gyre-driven decay of the Earth's magnetic dipole.

    PubMed

    Finlay, Christopher C; Aubert, Julien; Gillet, Nicolas

    2016-01-01

    Direct observations indicate that the magnitude of the Earth's magnetic axial dipole has decreased over the past 175 years; it is now 9% weaker than it was in 1840. Here we show how the rate of dipole decay may be controlled by a planetary-scale gyre in the liquid metal outer core. The gyre's meridional limbs on average transport normal polarity magnetic flux equatorward and reverse polarity flux poleward. Asymmetry in the geomagnetic field, due to the South Atlantic Anomaly, is essential to the proposed mechanism. We find that meridional flux advection accounts for the majority of the dipole decay since 1840, especially during times of rapid decline, with magnetic diffusion making an almost steady contribution generally of smaller magnitude. Based on the morphology of the present field, and the persistent nature of the gyre, the current episode of dipole decay looks set to continue, at least for the next few decades. PMID:26814368

  9. Gyre-driven decay of the Earth's magnetic dipole

    PubMed Central

    Finlay, Christopher C.; Aubert, Julien; Gillet, Nicolas

    2016-01-01

    Direct observations indicate that the magnitude of the Earth's magnetic axial dipole has decreased over the past 175 years; it is now 9% weaker than it was in 1840. Here we show how the rate of dipole decay may be controlled by a planetary-scale gyre in the liquid metal outer core. The gyre's meridional limbs on average transport normal polarity magnetic flux equatorward and reverse polarity flux poleward. Asymmetry in the geomagnetic field, due to the South Atlantic Anomaly, is essential to the proposed mechanism. We find that meridional flux advection accounts for the majority of the dipole decay since 1840, especially during times of rapid decline, with magnetic diffusion making an almost steady contribution generally of smaller magnitude. Based on the morphology of the present field, and the persistent nature of the gyre, the current episode of dipole decay looks set to continue, at least for the next few decades. PMID:26814368

  10. Gyre-driven decay of the Earth's magnetic dipole

    NASA Astrophysics Data System (ADS)

    Finlay, Christopher C.; Aubert, Julien; Gillet, Nicolas

    2016-01-01

    Direct observations indicate that the magnitude of the Earth's magnetic axial dipole has decreased over the past 175 years; it is now 9% weaker than it was in 1840. Here we show how the rate of dipole decay may be controlled by a planetary-scale gyre in the liquid metal outer core. The gyre's meridional limbs on average transport normal polarity magnetic flux equatorward and reverse polarity flux poleward. Asymmetry in the geomagnetic field, due to the South Atlantic Anomaly, is essential to the proposed mechanism. We find that meridional flux advection accounts for the majority of the dipole decay since 1840, especially during times of rapid decline, with magnetic diffusion making an almost steady contribution generally of smaller magnitude. Based on the morphology of the present field, and the persistent nature of the gyre, the current episode of dipole decay looks set to continue, at least for the next few decades.

  11. Reactions of State-Selected Atomic Oxygen Ions O(+)((4)S, (2)D, (2)P) with Methane.

    PubMed

    Cunha de Miranda, Barbara; Romanzin, Claire; Chefdeville, Simon; Vuitton, Véronique; Žabka, Jan; Polášek, Miroslav; Alcaraz, Christian

    2015-06-11

    An experimental study has been carried out on the reactions of state selected O(+)((4)S, (2)D, (2)P) ions with methane with the aims of characterizing the effects of both the parent ion internal energy and collision energy on the reaction dynamics and determining the fate of oxygen species in complex media, in particular the Titan ionosphere. Absolute cross sections and product velocity distributions have been determined for the reactions of (16)O(+) or (18)O(+) ions with CH4 or CD4 from thermal to 5 eV collision energies by using the guided ion beam (GIB) technique. Dissociative photoionization of O2 with vacuum ultraviolet (VUV) synchrotron radiation delivered by the DESIRS beamline at the SOLEIL storage ring and the threshold photoion photoelectron coincidence (TPEPICO) technique are used for the preparation of purely state-selected O(+)((4)S, (2)D, (2)P) ions. A complete inversion of the product branching ratio between CH4(+) and CH3(+) ions in favor of the latter is observed for excitation of O(+) ions from the (4)S ground state to either the (2)D or the (2)P metastable state. CH4(+) and CH3(+) ions, which are by far the major products for the reaction of ground state and excited states, are strongly backward scattered in the center of mass frame relative to O(+) parent ions. For the reaction of O(+)((4)S), CH3(+) production also rises with increasing collision energy but with much less efficiency than with O(+) excitation. We found that a mechanism of dissociative charge transfer, mediated by an initial charge transfer step, can account very well for all the observations, indicating that CH3(+) production is associated with the formation of H and O atoms (CH3(+) + H + O) rather than with OH formation by an hydride transfer process (CH3(+) + OH). Therefore, as the CH4(+) production by charge transfer is also associated with O atoms, the fate of oxygen species in these reactions is essentially the O production, except for the reaction of O(+)((4)S), which also

  12. Reactions of State-Selected Atomic Oxygen Ions O(+)((4)S, (2)D, (2)P) with Methane.

    PubMed

    Cunha de Miranda, Barbara; Romanzin, Claire; Chefdeville, Simon; Vuitton, Véronique; Žabka, Jan; Polášek, Miroslav; Alcaraz, Christian

    2015-06-11

    An experimental study has been carried out on the reactions of state selected O(+)((4)S, (2)D, (2)P) ions with methane with the aims of characterizing the effects of both the parent ion internal energy and collision energy on the reaction dynamics and determining the fate of oxygen species in complex media, in particular the Titan ionosphere. Absolute cross sections and product velocity distributions have been determined for the reactions of (16)O(+) or (18)O(+) ions with CH4 or CD4 from thermal to 5 eV collision energies by using the guided ion beam (GIB) technique. Dissociative photoionization of O2 with vacuum ultraviolet (VUV) synchrotron radiation delivered by the DESIRS beamline at the SOLEIL storage ring and the threshold photoion photoelectron coincidence (TPEPICO) technique are used for the preparation of purely state-selected O(+)((4)S, (2)D, (2)P) ions. A complete inversion of the product branching ratio between CH4(+) and CH3(+) ions in favor of the latter is observed for excitation of O(+) ions from the (4)S ground state to either the (2)D or the (2)P metastable state. CH4(+) and CH3(+) ions, which are by far the major products for the reaction of ground state and excited states, are strongly backward scattered in the center of mass frame relative to O(+) parent ions. For the reaction of O(+)((4)S), CH3(+) production also rises with increasing collision energy but with much less efficiency than with O(+) excitation. We found that a mechanism of dissociative charge transfer, mediated by an initial charge transfer step, can account very well for all the observations, indicating that CH3(+) production is associated with the formation of H and O atoms (CH3(+) + H + O) rather than with OH formation by an hydride transfer process (CH3(+) + OH). Therefore, as the CH4(+) production by charge transfer is also associated with O atoms, the fate of oxygen species in these reactions is essentially the O production, except for the reaction of O(+)((4)S), which also

  13. Mutations in transcription factor Mrr2p contribute to fluconazole resistance in clinical isolates of Candida albicans.

    PubMed

    Wang, Ying; Liu, Jin-Yan; Shi, Ce; Li, Wen-Jing; Zhao, Yue; Yan, Lan; Xiang, Ming-Jie

    2015-11-01

    The Candida albicans zinc cluster proteins are a family of transcription factors (TFs) that play essential roles in the development of antifungal drug resistance. Gain-of-function mutations in several TFs, such as Tac1p, Mrr1p and Upc2p, have been previously well documented in azole-resistant clinical C. albicans isolates. Mrr2p (multidrug resistance regulator 2) is a novel TF controlling expression of the ABC transporter gene CDR1 and mediating fluconazole resistance. In this study, the relationship between naturally occurring mutations in MRR2 and fluconazole resistance in clinical C. albicans isolates was investigated. Among a group of 20 fluconazole-resistant clinical C. albicans and 10 fluconazole-susceptible C. albicans, 12 fluconazole-resistant isolates overexpressed CDR1 by at least two-fold compared with the fluconazole-susceptible isolates. Of these 12 resistant isolates, three (C7, C9, C15) contained 11 identical missense mutations, 6 of which occurred only in the azole-resistant isolates. The contribution of these mutations to CDR1 overexpression and therefore to fluconazole resistance was further verified by generating recombinant strains containing the mutated MRR2 gene. The mutated MRR2 alleles from isolate C9 contributed to an almost six-fold increase in CDR1 expression and an eight-fold increase in fluconazole resistance; the missense mutations S466L and T470N resulted in an increase in CDR1 expression of more than two-fold and a four-fold increase in fluconazole resistance. In contrast, the other four missense mutations conferred only two- to four-fold increases in fluconazole resistance, with no significant increase in CDR1 expression. These findings provide some insight into the mechanism by which MRR2 regulates C. albicans multidrug resistance.

  14. Dark Matter Decays from Nonminimal Coupling to Gravity.

    PubMed

    Catà, Oscar; Ibarra, Alejandro; Ingenhütt, Sebastian

    2016-07-01

    We consider the standard model extended with a dark matter particle in curved spacetime, motivated by the fact that the only current evidence for dark matter is through its gravitational interactions, and we investigate the impact on the dark matter stability of terms in the Lagrangian linear in the dark matter field and proportional to the Ricci scalar. We show that this "gravity portal" induces decay even if the dark matter particle only has gravitational interactions, and that the decay branching ratios into standard model particles only depend on one free parameter: the dark matter mass. We study in detail the case of a singlet scalar as a dark matter candidate, which is assumed to be absolutely stable in flat spacetime due to a discrete Z_{2} symmetry, but which may decay in curved spacetimes due to a Z_{2}-breaking nonminimal coupling to gravity. We calculate the dark matter decay widths and we set conservative limits on the nonminimal coupling parameter from experiments. The limits are very stringent and suggest that there must exist an additional mechanism protecting the singlet scalar from decaying via this gravity portal. PMID:27447497

  15. Dark Matter Decays from Nonminimal Coupling to Gravity.

    PubMed

    Catà, Oscar; Ibarra, Alejandro; Ingenhütt, Sebastian

    2016-07-01

    We consider the standard model extended with a dark matter particle in curved spacetime, motivated by the fact that the only current evidence for dark matter is through its gravitational interactions, and we investigate the impact on the dark matter stability of terms in the Lagrangian linear in the dark matter field and proportional to the Ricci scalar. We show that this "gravity portal" induces decay even if the dark matter particle only has gravitational interactions, and that the decay branching ratios into standard model particles only depend on one free parameter: the dark matter mass. We study in detail the case of a singlet scalar as a dark matter candidate, which is assumed to be absolutely stable in flat spacetime due to a discrete Z_{2} symmetry, but which may decay in curved spacetimes due to a Z_{2}-breaking nonminimal coupling to gravity. We calculate the dark matter decay widths and we set conservative limits on the nonminimal coupling parameter from experiments. The limits are very stringent and suggest that there must exist an additional mechanism protecting the singlet scalar from decaying via this gravity portal.

  16. Theoretical implications of 0νββ decay measurements

    SciTech Connect

    Hirsch, Martin

    2015-07-15

    Lower limits on the half-life of neutrinoless double beta (0νββ) decay are usually interpreted as an upper limit on the effective Majorana neutrino mass. However, from a theoretical point of view 0νββ decay is an effective dimension-9 (ΔL = 2) operator, O{sub 0νββ}, for which the mass mechanism is only one possible realization. Any new physics model, which allows for lepton number violation (LNV), will contribute to the 0νββ decay amplitude. Here, after some preliminaries, I will discuss the general decomposition of O{sub 0νββ}. Most “exotic” contributions to 0νββ decay are of the so-called “short-range” type, i.e. involve heavy, electrically charged (and/or coloured) particles. Thus, current and future LHC data will put these exotic contributions to the test and either discover signals for LNV or rule out most cases as possible explanations of a hypothetical future signal of 0νββ decay.

  17. Direct binding of the Kex2p cytosolic tail to the VHS domain of yeast Gga2p facilitates TGN to prevacuolar compartment transport and is regulated by phosphorylation

    PubMed Central

    De, Mithu; Abazeed, Mohamed E.; Fuller, Robert S.

    2013-01-01

    Human Golgi-localized, γ-ear–containing, ADP-ribosylation factor–binding proteins (Ggas) bind directly to acidic dileucine sorting motifs in the cytosolic tails (C-tails) of intracellular receptors. Despite evidence for a role in recruiting ubiquitinated cargo, it remains unclear whether yeast Ggas also function by binding peptide-sorting signals directly. Two-hybrid analysis shows that the Gga1p and Gga2p Vps27, Hrs, Stam (VHS) domains both bind a site in the Kex2p C-tail and that the Gga2p VHS domain binds a site in the Vps10p C-tail. Binding requires deletion of an apparently autoinhibitory sequence in the Gga2p hinge. Ser780 in the Kex2p C-tail is crucial for binding: an Ala substitution blocks but an Asp substitution permits binding. Biochemical assays using purified Gga2p VHS–GGA and TOM1 (GAT) and glutathione S-transferase–Kex2p C-tail fusions show that Gga2p binds directly to the Kex2p C-tail, with relative affinities Asp780 > Ser780 > Ala780. Affinity-purified antibody against a peptide containing phospho-Ser­780 recognizes wild-type Kex2p but not S780A Kex2p, showing that Ser780 is phosphorylated in vivo; phosphorylation of Ser780 is up-regulated by cell wall–damaging drugs. Finally, mutation of Ser780 alters trafficking of Kex2p both in vivo and in cell-free trans-Golgi network (TGN)–prevacuolar compartment (PVC) transport. Thus yeast Gga adaptors facilitate TGN–PVC transport by direct binding of noncanonical phosphoregulated Gga-binding sites in cargo molecules. PMID:23408788

  18. Conceptual Modeling of mRNA Decay Provokes New Hypotheses

    PubMed Central

    Somekh, Judith; Haimovich, Gal; Guterman, Adi; Dori, Dov; Choder, Mordechai

    2014-01-01

    Biologists are required to integrate large amounts of data to construct a working model of the system under investigation. This model is often informal and stored mentally or textually, making it prone to contain undetected inconsistencies, inaccuracies, or even contradictions, not much less than a representation in free natural language. Using Object-Process Methodology (OPM), a formal yet visual and humanly accessible conceptual modeling language, we have created an executable working model of the mRNA decay process in Saccharomyces cerevisiae, as well as the import of its components to the nucleus following mRNA decay. We show how our model, which incorporates knowledge from 43 articles, can reproduce outcomes that match the experimental findings, evaluate hypotheses, and predict new possible outcomes. Moreover, we were able to analyze the effects of the mRNA decay model perturbations related to gene and interaction deletions, and predict the nuclear import of certain decay factors, which we then verified experimentally. In particular, we verified experimentally the hypothesis that Rpb4p, Lsm1p, and Pan2p remain bound to the RNA 3′-untralslated region during the entire process of the 5′ to 3′ degradation of the RNA open reading frame. The model has also highlighted erroneous hypotheses that indeed were not in line with the experimental outcomes. Beyond the scientific value of these specific findings, this work demonstrates the value of the conceptual model as an in silico vehicle for hypotheses generation and testing, which can reinforce, and often even replace, risky, costlier wet lab experiments. PMID:25255440

  19. Dissociative recombination of molecular ions in the He-Ne plasma. Partial rate constants of atoms formation in the 2 p 53d and 2 p 54d configurations

    NASA Astrophysics Data System (ADS)

    Ivanov, V. A.; Petrovskaya, A. S.; Skoblo, Yu. E.

    2016-02-01

    A spectroscopic study of population processes was carried out for states of the neon atom of the 2 p 53 d configuration in the discharge afterglow in helium with a small admixture of neon ([Ne]/[He] ≈ 10-5) at a pressure of 38 Torr. Based on the comparative analysis of time dependences of the spectral line intensities of the Ne I 2 p 53 d → 2 p 53 d and 2 p 54 d → 2 p 53 d transitions and ratio of ion densities [Ne 2 + ]/[HeNe+], it has been found that the formation of excited Ne(2 p 53 d) atoms in the afterglow caused by two dissociative recombination processes: HeNe+ + e → Ne(2 p 53 d) + Ne and Ne 2 + + e → Ne(2 p 53 d) + Ne. Distributions of population fluxes of the 2 p 53 d levels Γ _{3{d_t}}^{HeN{e^ + }} and Γ _{3{d_t}}^{Ne_2^ + }—were obtained for each of these processes.

  20. Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K[superscript +] Ion Channel

    SciTech Connect

    Brohawn, Stephen G.; del Mármol, Josefina; MacKinnon, Roderick

    2012-03-01

    TRAAK channels, members of the two-pore domain K{sup +} (potassium ion) channel family K2P, are expressed almost exclusively in the nervous system and control the resting membrane potential. Their gating is sensitive to polyunsaturated fatty acids, mechanical deformation of the membrane, and temperature changes. Physiologically, these channels appear to control the noxious input threshold for temperature and pressure sensitivity in dorsal root ganglia neurons. We present the crystal structure of human TRAAK at a resolution of 3.8 angstroms. The channel comprises two protomers, each containing two distinct pore domains, which create a two-fold symmetric K{sup +} channel. The extracellular surface features a helical cap, 35 angstroms tall, that creates a bifurcated pore entry way and accounts for the insensitivity of two-pore domain K{sup +} channels to inhibitory toxins. Two diagonally opposed gate-forming inner helices form membrane-interacting structures that may underlie this channel's sensitivity to chemical and mechanical properties of the cell membrane.

  1. Gaussian Confinement in a Jkj Decay Model

    NASA Astrophysics Data System (ADS)

    da Silva, Mario L. L.; Hadjimichef, Dimiter; Vasconcellos, Cesar A. Z.

    In microscopic decay models, one attempts to describe hadron strong decays in terms of quark and gluon degrees of freedom. We begin by assuming that strong decays are driven by the same interquark Hamiltonian which determines the spectrum, and that it incorporates gaussian confinement. An A → BC decay matrix element of the JKJ Hamiltonian involves a pair-production current matrix elements times a scatering matrix element. Diagrammatically this corresponds to an interaction between an initial line and produced pair.

  2. Review of J//psi/ decays

    SciTech Connect

    Toki, W.H.

    1988-11-01

    Recent results from the Mark III collaboration in radiative J//psi/ decays are presented. This includes a study of iota/E decays in J//psi/ el/eta/ and elelp, two pseudoscalar decays near threshold in J//psi/ el and el /bar K/K and two vector decays in J//psi/ el /bar K//sup o/*K/sup o/*. 20 refs., 9 figs.

  3. MAGNETIC FIELD-DECAY-INDUCED ELECTRON CAPTURES: A STRONG HEAT SOURCE IN MAGNETAR CRUSTS

    SciTech Connect

    Cooper, Randall L.; Kaplan, David L. E-mail: dkaplan@kitp.ucsb.edu

    2010-01-10

    We propose a new heating mechanism in magnetar crusts. Magnetars' crustal magnetic fields are much stronger than their surface fields; therefore, magnetic pressure partially supports the crust against gravity. The crust loses magnetic pressure support as the field decays and must compensate by increasing the electron degeneracy pressure; the accompanying increase in the electron Fermi energy induces nonequilibrium, exothermic electron captures. The total heat released via field-decay electron captures is comparable to the total magnetic energy in the crust. Thus, field-decay electron captures are an important, if not the primary, mechanism powering magnetars' soft X-ray emission.

  4. Crystallization and crystallographic analysis of yeast Sec2p, a guanine nucleotide-exchange factor for the yeast Rab GTPase Sec4p

    SciTech Connect

    Sato, Yusuke; Fukai, Shuya; Nureki, Osamu

    2007-07-01

    Crystal structure of a triple mutant (M115L, K121M, T142M) of SeMet-labelled Sec2p, a GEF for Rab GTPase, has been solved by SAD. Control of the selenium sites by mutagenesis much improved the resolution of the SeMet-labelled crystals. Sec2p is a guanine nucleotide-exchange factor (GEF) for the yeast Rab GTPase Sec4p. Sec2p accelerates GDP release from Sec4p and promotes GDP–GTP exchange for Sec4p activation. In order to elucidate this nucleotide-exchange mechanism using X-ray crystallography, three constructs of native Sec2p (Sec2{sub 1–160}p, Sec2{sub 18–160}p and Sec2{sub 31–160}p) and three constructs of selenomethionine-labelled Sec2p [Sec2{sub 31–160}p, Sec2{sub 31–160}p (M115L) and Sec2{sub 31–160}p (M115L, K121M, T142M)] were crystallized. These six crystals diffracted to 8.8, 4.8, 2.6, 4.0, 3.3 and 3.0 Å resolution, respectively. The data set from the SeMet-labelled Sec2{sub 31–160}p (M115L, K121M, T142M) crystal was processed for SAD phasing; the crystal belonged to space group P2{sub 1}2{sub 1}2{sub 1}, with unit-cell parameters a = 101.9, b = 176.6, c = 181.5 Å.

  5. Expression of bcl-2, p53 and Ki-67 in arsenical skin cancers.

    PubMed

    Chang, C H; Tsai, R K; Chen, G S; Yu, H S; Chai, C Y

    1998-10-01

    To investigate the regulation of apoptosis and proliferation in arsenic-induced skin cancers, we examined the expression of bcl-2, p53, and Ki-67 using immunohistochemical staining. Thirty patients with Bowen's disease (BD), ten with basal cell carcinoma (BCC), eight with squamous cell carcinoma (SCC) and eleven of perilesional normal skin (PLN) of the non-sun exposure sites from endemic area were examined. The results showed that: 1) bcl-2 was expressed in all of the BCC homogeneously, in none of the SCC, and in 12/30 of the BD focally or homogeneously; 2) p53 was expressed in all of the arsenical skin cancers with a labelling index of 75 +/- 14% of BD, 50 +/- 17% of BCC, 61 +/- 15% of SCC, and also in all of the perilesional normal skin with a labelling index of 55 +/- 24%; 3) Ki-67 was expressed in all of the skin cancers with labelling index of 58 +/- 17% of BD, 12 +/- 7% of BCC, 47 +/- 21% of SCC, and in 9/11 of PLN with a labelling index of 41 +/- 24%. Expression of bcl-2 in BCC or BD is related to the phenotype of germinative basal cell. The constant expression of bcl-2 i early dysplastic cells of BD and the earliest expression of P53 in the basal cells of perilesional normal skin indicate that the initial step of arsenic-induced carcinogenesis is from the basal germinative cells. There is no mutual relationship between bcl-2, p53 or Ki-67 expression in any type of the arsenical skin cancers, but there is a positive correlation between p53 and Ki-67 expression identified in perilesional normal skin. BD had the highest labelling index of p53 and Ki-67.

  6. Molecular Orbital Simulations of Metal 1s2p Resonant Inelastic X-ray Scattering.

    PubMed

    Guo, Meiyuan; Källman, Erik; Sørensen, Lasse Kragh; Delcey, Mickaël G; Pinjari, Rahul V; Lundberg, Marcus

    2016-07-28

    For first-row transition metals, high-resolution 3d electronic structure information can be obtained using resonant inelastic X-ray scattering (RIXS). In the hard X-ray region, a K pre-edge (1s→3d) excitation can be followed by monitoring the dipole-allowed Kα (2p→1s) or Kβ (3p→1s) emission, processes labeled 1s2p or 1s3p RIXS. Here the restricted active space (RAS) approach, which is a molecular orbital method, is used for the first time to study hard X-ray RIXS processes. This is achieved by including the two sets of core orbitals in different partitions of the active space. Transition intensities are calculated using both first- and second-order expansions of the wave vector, including, but not limited to, electric dipoles and quadrupoles. The accuracy of the approach is tested for 1s2p RIXS of iron hexacyanides [Fe(CN)6](n-) in ferrous and ferric oxidation states. RAS simulations accurately describe the multiplet structures and the role of 2p and 3d spin-orbit coupling on energies and selection rules. Compared to experiment, relative energies of the two [Fe(CN)6](3-) resonances deviate by 0.2 eV in both incident energy and energy transfer directions, and multiplet splittings in [Fe(CN)6](4-) are reproduced within 0.1 eV. These values are similar to what can be expected for valence excitations. The development opens the modeling of hard X-ray scattering processes for both solution catalysts and enzymatic systems. PMID:27398775

  7. Affinity Purification and Characterization of a G-Protein Coupled Receptor, Saccharomyces cerevisiae Ste2p

    SciTech Connect

    Lee, Byung-Kwon; Jung, Kyung-Sik; Son, Cagdas D; Kim, Heejung; Verberkmoes, Nathan C; Arshava, Boris; Naider, Fred; Becker, Jeffrey Marvin

    2007-01-01

    We present a rare example of a biologically active G protein coupled receptor (GPCR) whose purity and identity were verified by mass spectrometry after being purified to near homogeneity from its native system. An overexpression vector was constructed to encode the Saccharomyces cerevisiae GPCR -factor receptor (Ste2p, the STE2 gene product) containing a 9-amino acid sequence of rhodopsin that served as an epitope/affinity tag. In the construct, two glycosylation sites and two cysteine residues were removed to aid future structural and functional studies. The receptor was expressed in yeast cells and was detected as a single band in a western blot indicating the absence of glycosylation. Tests of the epitope-tagged, mutated receptor showed it maintained its full biological activity. For extraction of Ste2p, yeast membranes were solubilized with 0.5 % n-dodecyl maltoside (DM). Approximately 120 g of purified -factor receptor was obtained per liter of culture by single-step affinity chromatography using a monoclonal antibody to the rhodopsin epitope. The binding affinity (Kd) of the purified -factor receptor in DM micelles was 28 nM as compared to Kd = 12.7 nM for Ste2p in cell membranes, and approximately 40 % of the purified receptor was correctly folded as judged by ligand saturation binding. About 50 % of the receptor sequence was retrieved from MALDITOF and nanospray mass spectrometry after CNBr digestion of the purified receptor. The methods described will enable structural studies of the -factor receptor and may provide an efficient technique to purify other GPCRs that have been functionally expressed in yeast.

  8. Double beta decay: A theoretical overview

    SciTech Connect

    Rosen, S.P.

    1988-01-01

    This paper reviews the theoretical possibility of double beta decay. The titles of the main sections of this paper are: Nuclear physics setting; Particle physics requirements; Kinematical features of the decay modes; Nuclear matrix elements; the Shell model and two-neutrino decay; Quasi-particle random phase approximation; and Future considerations. 18 refs., 7 tabs. (LSP)

  9. Weak radiative baryonic decays of B mesons

    SciTech Connect

    Kohara, Yoji

    2004-11-01

    Weak radiative baryonic B decays B{yields}B{sub 1}B{sub 2}-bar{gamma} are studied under the assumption of the short-distance b{yields}s{gamma} electromagnetic penguin transition dominance. The relations among the decay rates of various decay modes are derived.

  10. Penguin and rare decays in BABAR

    NASA Astrophysics Data System (ADS)

    Akar, Simon; Babar Collaboration

    2014-11-01

    We present recent results from the BABAR Collaboration on radiative decays. These include searches for new physics via measurements of several observables such as the time- dependent CP asymmetry in B0 → K0Sπ-π+γ exclusive decays, as well as direct CP asymmetries and branching fractions in B → Xsγ and B → Xsl+l- inclusive decays.

  11. Beauty baryon decays: a theoretical overview

    NASA Astrophysics Data System (ADS)

    Wang, Yu-Ming

    2014-11-01

    I overview the theoretical status and recent progress on the calculations of beauty baryon decays focusing on the QCD aspects of the exclusive semi-leptonic Λb → plμ decay at large recoil and theoretical challenges of radiative and electro-weak penguin decays Λb → Λγ,Λl+l-.

  12. Recent results on semileptonic decays at BABAR

    NASA Astrophysics Data System (ADS)

    Serrano, J.; Babar Collaboration

    2009-01-01

    Some recent BABAR results on semileptonic decays are presented. They focus on the determination of the CKM matrix elements |V| and |V| in inclusive and exclusive b→uℓν and b→cℓν decays, and on form factors measurement in exclusive c→sℓν decays.

  13. Review of B and Bs decays

    NASA Astrophysics Data System (ADS)

    Bozzi, Concezio

    2014-05-01

    A review of B and Bs decays is presented. Emphasis is given to processes most sensitive to physics beyond the Standard Model, such as radiative, electroweak and "Higgs" penguin decays, and tree-level decays involving tau leptons in the final state. An outlook on future perspectives is also given.

  14. Wave mixing in nominally undoped Sn2P2S6 at high light intensities

    NASA Astrophysics Data System (ADS)

    Shumelyuk, A.; Wesner, M.; Imlau, M.; Odoulov, S.

    2009-06-01

    The intensity dependence of the photorefractive response of Sn2P2S6 is studied for the Kr+-laser wavelength of 647 nm and pump-beam intensities of up to 10 W/cm2. A considerable enhancement of the two-beam coupling gain factor with increasing intensity at a grating spacing of ≃1 μm is attributed to a light-induced increase of the effective trap density. The large gain reached at high intensities is applied for the build up of a double phase conjugate mirror with a sub-millisecond switch-on time.

  15. Hermès, a collaborative environment at IN2P3

    NASA Astrophysics Data System (ADS)

    Helft, Christian

    2010-04-01

    IN2P3, the institute bringing together HEP laboratories in France, opened a videoconferencing service in 2002 based on an industry standard H323 MCU (Multiple Control Unit). This service has steadily grown since then, serving other French scientific communities in addition to HEP and reaching an average of about thirty conferences a day. The relatively small amount of manpower required to deploy and maintain this facility can be explained by the very sound design and the large array of built-in capabilities offered by the equipment that replaced the original equipment purchased in 2005.

  16. Negative photoion spectroscopy of freon molecules in the vicinity of the Cl 2p edge

    SciTech Connect

    Scully, S.W.J.; Mackie, R.A.; Browning, R.; Dunn, K.F.; Latimer, C.J.

    2004-10-01

    Polar photodissociation of CF{sub n}Cl{sub 4-n} (n=0-2) has been studied using synchrotron radiation within the energy range 195-217 eV. The first observations of negative photoion fragments from these molecules after core excitation are reported. In addition to observing a number of previously known resonances two additional resonant states, just above the Cl 2p ionization limit, are observed and play an important role in the polar photodissociation process. The difficulties in identifying these above threshold spin-split features using negative photoion spectroscopy are discussed.

  17. Acoustic and elastic properties of Sn(2)P(2)S(6) crystals.

    PubMed

    Mys, O; Martynyuk-Lototska, I; Grabar, A; Vlokh, R

    2009-07-01

    We present the results concerned with acoustic and elastic properties of Sn(2)P(2)S(6) crystals. The complete matrices of elastic stiffness and compliance coefficients are determined in both the crystallographic coordinate system and the system associated with eigenvectors of the elastic stiffness tensor. The acoustic slowness surfaces are constructed and the propagation and polarization directions of the slowest acoustic waves promising for acousto-optic interactions are determined on this basis. The acoustic obliquity angle and the deviation of polarization of the acoustic waves from purely transverse or longitudinal states are quantitatively analysed.

  18. Electron-phonon interaction and superconductivity in BaIr2P2.

    PubMed

    Billington, D

    2016-10-01

    Detailed calculations of the electronic structure, phonons and electron-phonon coupling of the superconducting compound BaIr2P2 were performed from first-principles. The electronic structure showed excellent agreement with the available experimental data. The total electron-phonon coupling constant was [Formula: see text] and the logarithmically averaged phonon frequency was [Formula: see text] K. From the Allen-Dynes formula, with [Formula: see text], the superconducting critical temperature was estimated to be [Formula: see text] K, which is in excellent agreement with the experiment. These results indicate that the electron-phonon coupling is of moderate strength and is easily capable of supporting the observed superconductivity.

  19. Towards accurate node-based detection of P2P botnets.

    PubMed

    Yin, Chunyong

    2014-01-01

    Botnets are a serious security threat to the current Internet infrastructure. In this paper, we propose a novel direction for P2P botnet detection called node-based detection. This approach focuses on the network characteristics of individual nodes. Based on our model, we examine node's flows and extract the useful features over a given time period. We have tested our approach on real-life data sets and achieved detection rates of 99-100% and low false positives rates of 0-2%. Comparison with other similar approaches on the same data sets shows that our approach outperforms the existing approaches.

  20. The Measurement and Modeling of a P2P Streaming Video Service

    NASA Astrophysics Data System (ADS)

    Gao, Peng; Liu, Tao; Chen, Yanming; Wu, Xingyao; El-Khatib, Yehia; Edwards, Christopher

    Most of the work on grid technology in video area has been generally restricted to aspects of resource scheduling and replica management. The traffic of such service has a lot of characteristics in common with that of the traditional video service. However the architecture and user behavior in Grid networks are quite different from those of traditional Internet. Considering the potential of grid networks and video sharing services, measuring and analyzing P2P IPTV traffic are important and fundamental works in the field grid networks.

  1. Electronic Structure and Phase Transition in Ferroelectic Sn2P2S6 Crystal

    PubMed Central

    Glukhov, Konstantin; Fedyo, Kristina; Banys, Juras; Vysochanskii, Yulian

    2012-01-01

    An analysis of the P2S6 cluster electronic structure and its comparison with the crystal valence band in the paraelectric and ferroelectric phases has been done by first-principles calculations for Sn2P2S6 ferroelectrics. The origin of ferroelectricity has been outlined. It was established that the spontaneous polarization follows from the stereochemical activity of the electron lone pair of tin cations, which is determined by hybridization with P2S6 molecular orbitals. The chemical bonds covalence increase and rearrangement are related to the valence band changes at transition from the paraelectric phase to the ferroelectric phase. PMID:23203069

  2. Towards Accurate Node-Based Detection of P2P Botnets

    PubMed Central

    2014-01-01

    Botnets are a serious security threat to the current Internet infrastructure. In this paper, we propose a novel direction for P2P botnet detection called node-based detection. This approach focuses on the network characteristics of individual nodes. Based on our model, we examine node's flows and extract the useful features over a given time period. We have tested our approach on real-life data sets and achieved detection rates of 99-100% and low false positives rates of 0–2%. Comparison with other similar approaches on the same data sets shows that our approach outperforms the existing approaches. PMID:25089287

  3. A 2-substituted prodiginine, 2-(p-hydroxybenzyl)prodigiosin, from Pseudoalteromonas rubra.

    PubMed

    Fehér, Domonkos; Barlow, Russell S; Lorenzo, Patricia S; Hemscheidt, Thomas K

    2008-11-01

    In the course of work aimed at the discovery of new pharmaceutical lead compounds from marine bacteria, a lipophilic extract of the bacterium Pseudoalteromonas rubra displayed significant cytotoxicity against SKOV-3, a human ovarian adenocarcinoma cell line. Bioassay-directed fractionation of this extract resulted in the isolation of a series of known and new prodiginine-type azafulvenes. The structure of the major metabolite was elucidated by interpretation of spectroscopic data as a 2-substituted prodigiosin, which we named 2-(p-hydroxybenzyl)prodigiosin (HBPG).

  4. A Small Conserved Domain in the Yeast Spa2p Is Necessary and Sufficient for Its Polarized Localization

    PubMed Central

    Arkowitz, Robert A.; Lowe, Nick

    1997-01-01

    SPA2 encodes a yeast protein that is one of the first proteins to localize to sites of polarized growth, such as the shmoo tip and the incipient bud. The dynamics and requirements for Spa2p localization in living cells are examined using Spa2p green fluorescent protein fusions. Spa2p localizes to one edge of unbudded cells and subsequently is observable in the bud tip. Finally, during cytokinesis Spa2p is present as a ring at the mother–daughter bud neck. The bud emergence mutants bem1 and bem2 and mutants defective in the septins do not affect Spa2p localization to the bud tip. Strikingly, a small domain of Spa2p comprised of 150 amino acids is necessary and sufficient for localization to sites of polarized growth. This localization domain and the amino terminus of Spa2p are essential for its function in mating. Searching the yeast genome database revealed a previously uncharacterized protein which we name, Sph1p (Spa2p homolog), with significant homology to the localization domain and amino terminus of Spa2p. This protein also localizes to sites of polarized growth in budding and mating cells. SPH1, which is similar to SPA2, is required for bipolar budding and plays a role in shmoo formation. Overexpression of either Spa2p or Sph1p can block the localization of either protein fused to green fluorescent protein, suggesting that both Spa2p and Sph1p bind to and are localized by the same component. The identification of a 150–amino acid domain necessary and sufficient for localization of Spa2p to sites of polarized growth and the existence of this domain in another yeast protein Sph1p suggest that the early localization of these proteins may be mediated by a receptor that recognizes this small domain. PMID:9214378

  5. Quantum zeno paradox: Survival and decay

    NASA Astrophysics Data System (ADS)

    Chiu, Charles B.

    2009-11-01

    Quantum mechanics enables the calculation of the time evolution of a dynamical system provided the Hamiltonian is defined and the initial state is specified. Due to the time reversal invariance, the time evolution of a given initial state at t=0 does not have a time-arrow. These problems have been extensively studied by E. C. G. Sudarshan and collaborators, including myself. Here the survival probability, which is the square of the survival amplitude, is an even function of t. Using the survival amplitude as a common framework, we discuss Zeno effects in several processes: the decay of an unstable particle, pion productions in proton-nucleus collisions and the Aharonov-Vardi effect which is another manifestation of the Zeno effect.

  6. Noncharacteristic half-lives in radioactive decay.

    PubMed

    Corral, Alvaro; Font, Francesc; Camacho, Juan

    2011-06-01

    Half-lives of radionuclides span more than 50 orders of magnitude. We characterize the probability distribution of this broad-range data set at the same time that we explore a method for fitting power laws and testing goodness-of-fit. It is found that the procedure proposed recently by Clauset et al. [SIAM Rev. 51, 661 (2009)] does not perform well as it rejects the power-law hypothesis even for power-law synthetic data. In contrast, we establish the existence of a power-law exponent with a value around 1.1 for the half-life density, which can be explained by the sharp relationship between decay rate and released energy, for different disintegration types. For the case of alpha emission, this relationship constitutes an original mechanism of power-law generation.

  7. Structure and decay correlations of two-neutron systems beyond the dripline

    NASA Astrophysics Data System (ADS)

    Kohley, Z.; Baumann, T.; Bazin, D.; Christian, G.; De Young, P. A.; Finck, J. E.; Haring-Kaye, R. A.; Hinnefeld, J.; Frank, N.; Lunderberg, E.; Luther, B.; Mosby, S.; Peters, W. A.; Smith, J. K.; Snyder, J.; Stephenson, S. L.; Strongman, M. J.; Spyrou, A.; Thoennessen, M.; Volya, A.

    2014-12-01

    The two-neutron unbound systems of 16Be, 13Li, 10He, and 26O have been measured using the Modular Neutron Array (MoNA) and 4 Tm Sweeper magnet setup. The correlations of the 3-body decay for the 6Be and 3Li were extracted and demonstrated a strong correlated enhancement between the two neutrons. The measurement of the 10He ground state resonance from a 14Be(-2p2n) reaction provided insight into previous predictions that wavefunction of the entrance channel, projectile, can influence the observed decay energy spectrum for the unbound system. Lastly, the decay-in-target (DiT) technique was utilized to extract the lifetime of the 26O ground state. The measured lifetime of 4.5+1.1-1.5(stat.)±3(sys.) ps provides the first indication of two-neutron radioactivity.

  8. Decay data evaluation project (DDEP): updated evaluations of the 233Th and 241Am decay characteristics.

    PubMed

    Chechev, Valery P; Kuzmenko, Nikolay K

    2010-01-01

    The results of new decay data evaluations are presented for (233)Th (beta(-)) decay to nuclear levels in (233)Pa and (241)Am (alpha) decay to nuclear levels in (237)Np. These evaluated data have been obtained within the Decay Data Evaluation Project using information published up to 2009.

  9. Decay Data Evaluation Project (DDEP): evaluation of the main 243Cm and 245Cm decay characteristics.

    PubMed

    Chechev, Valery P

    2012-09-01

    The results of new decay data evaluations are presented for (243)Cm (α) decay to nuclear levels in (239)Pu and (245)Cm (α) decay to nuclear levels in (241)Pu. These evaluated data have been obtained within the Decay Data Evaluation Project using information published up to 2011.

  10. Form factors and decay rate of Bc * Dsl+l- decays in the QCD sum rules

    NASA Astrophysics Data System (ADS)

    Zeynali, K.; Bashiry, V.; Zolfagharpour, F.

    2014-08-01

    Rare exclusive decays are analyzed in the framework of the three-point QCD sum rules approach. The two-gluon condensate corrections to the correlation function are included and the form factors of this transition are evaluated. Using the form factors, the decay width and integrated decay rate for these decays are also calculated.

  11. Decays of the tau lepton

    SciTech Connect

    Burchat, P.R.

    1986-02-01

    Previous measurements of the branching fractions of the tau lepton result in a discrepancy between the inclusive branching fraction and the sum of the exclusive branching fractions to final states containing one charged particle. The sum of the exclusive branching fractions is significantly smaller than the inclusive branching fraction. In this analysis, the branching fractions for all the major decay modes are measured simultaneously with the sum of the branching fractions constrained to be one. The branching fractions are measured using an unbiased sample of tau decays, with little background, selected from 207 pb/sup -1/ of data accumulated with the Mark II detector at the PEP e/sup +/e/sup -/ storage ring. The sample is selected using the decay products of one member of the ..gamma../sup +/..gamma../sup -/ pair produced in e/sup +/e/sup -/ annihilation to identify the event and then including the opposite member of the pair in the sample. The sample is divided into subgroups according to charged and neutral particle multiplicity, and charged particle identification. The branching fractions are simultaneously measured using an unfold technique and a maximum likelihood fit. The results of this analysis indicate that the discrepancy found in previous experiments is possibly due to two sources. First, the leptonic branching fractions measured in this analysis are about one standard deviation higher than the world average. The measured leptonic branching fractions correspond to a tau lifetime of (3.0 +- 0.2) x 10/sup -13/ s. Secondly, the total branching fraction to one charged hadron plus at least one neutral particle is measured to be (7 +- 3)% higher than the branching fraction expected from a combination of previous measurements and theoretical predictions. It is shown that decay modes involving the eta are not expected to contribute more than 3% to this excess.

  12. Optical spectroscopy and tooth decay

    NASA Astrophysics Data System (ADS)

    Misra, P.; De, T.; Singh, R.

    2005-11-01

    Optical spectroscopy in the ultraviolet, visible and mid-infrared spectral regions has been used to discriminate between healthy and diseased teeth of patients in the age range 15-75 years. Spectral scans of absorbance versus wavenumber and fluorescence intensity versus wavelength have been recorded and investigated for caries and periodontal disease. Such optical diagnostics can prove very useful in the early detection and treatment of tooth decay.

  13. Nuclear structure from radioactive decay

    SciTech Connect

    Wood, J.L.

    1991-09-30

    This report discusses nuclear structure from radioactive decay of the following: Neutron-Deficient Iridium Isotopes; Neutron-Deficient Platinum Isotopes; Neutron-Deficient Gold Isotopes; Neutron-Deficient Mercury Isotopes; Neutron-Deficient Thallium Isotopes; Neutron-Deficient Lead Isotopes; Neutron-Deficient Samarium Isotopes; Neutron-Deficient Promethium Isotopes; Neutron-Deficient Neodymium Isotopes; and Neutron-Deficient Praseodymium Isotopes. Also discussed are Nuclear Systematics and Models.

  14. In situ ultrahigh vacuum transmission electron microscopy study of quasi-one-dimensional island decay on isotropic Ge(001) surface

    NASA Astrophysics Data System (ADS)

    Li, Zhi-Peng; Tok, Eng Soon; Foo, Yong Lim

    2010-10-01

    In situ ultrahigh vacuum transmission electron microscopy was employed to observe the dynamics of both the coalescence and decay of two-dimensional Fe13Ge8 islands on an atomically smooth Ge(001) surface. Quasi-one-dimensional (1D) island decay behavior was observed on the isotropic Ge(001) surface where annealing caused the islands to shrink significantly faster in one direction. The shrinkage in the perpendicular direction was minimal in comparison. This is contrary to Ostwald ripening for isotropic surfaces, as well as for the quasi-1D island decay model for anisotropic surfaces. During annealing, this island decay behavior occurred by the attachment/detachment limiting mechanism, which is based on an analysis of adatom concentration differences. Therefore, this quasi-1D island decay process is driven by adatom concentration differences between coalescing and decaying islands. Island decay occurs along the large diffusive flux channel between islands and is affected by the local environment.

  15. Virus decay and its causes in coastal waters.

    PubMed

    Noble, R T; Fuhrman, J A

    1997-01-01

    Recent evidence suggests that viruses play an influential role within the marine microbial food web. To understand this role, it is important to determine rates and mechanisms of virus removal and degradation. We used plaque assays to examine the decay of infectivity in lab-grown viruses seeded into natural seawater. The rates of loss of infectivity of native viruses from Santa Monica Bay and of nonnative viruses from the North Sea in the coastal seawater of Santa Monica Bay were determined. Viruses were seeded into fresh seawater that had been pretreated in various ways: filtration with a 0.2-(mu)m-pore-size filter to remove organisms, heat to denature enzymes, and dissolved organic matter enrichment to reconstitute enzyme activity. Seawater samples were then incubated in full sunlight, in the dark, or under glass to allow partitioning of causative agents of virus decay. Solar radiation always resulted in increased rates of loss of virus infectivity. Virus isolates which are native to Santa Monica Bay consistently degraded more slowly in full sunlight in untreated seawater (decay ranged from 4.1 to 7.2% h(sup-1)) than nonnative marine bacteriophages which were isolated from the North Sea (decay ranged from 6.6 to 11.1% h(sup-1)). All phages demonstrated susceptibility to degradation by heat-labile substances, as heat treatment reduced the decay rates to about 0.5 to 2.0% h(sup-1) in the dark. Filtration reduced decay rates by various amounts, averaging 20%. Heat-labile, high-molecular-weight dissolved material (>30 kDa, probably enzymes) appeared responsible for about 1/5 of the maximal decay. Solar radiation was responsible for about 1/3 to 2/3 of the maximal decay of nonnative viruses and about 1/4 to 1/3 of that of the native viruses, suggesting evolutionary adaptation to local light levels. Our results suggest that sunlight is an important contributing factor to virus decay but also point to the significance of particles and dissolved substances in seawater.

  16. Virus decay and its causes in coastal waters.

    PubMed

    Noble, R T; Fuhrman, J A

    1997-01-01

    Recent evidence suggests that viruses play an influential role within the marine microbial food web. To understand this role, it is important to determine rates and mechanisms of virus removal and degradation. We used plaque assays to examine the decay of infectivity in lab-grown viruses seeded into natural seawater. The rates of loss of infectivity of native viruses from Santa Monica Bay and of nonnative viruses from the North Sea in the coastal seawater of Santa Monica Bay were determined. Viruses were seeded into fresh seawater that had been pretreated in various ways: filtration with a 0.2-(mu)m-pore-size filter to remove organisms, heat to denature enzymes, and dissolved organic matter enrichment to reconstitute enzyme activity. Seawater samples were then incubated in full sunlight, in the dark, or under glass to allow partitioning of causative agents of virus decay. Solar radiation always resulted in increased rates of loss of virus infectivity. Virus isolates which are native to Santa Monica Bay consistently degraded more slowly in full sunlight in untreated seawater (decay ranged from 4.1 to 7.2% h(sup-1)) than nonnative marine bacteriophages which were isolated from the North Sea (decay ranged from 6.6 to 11.1% h(sup-1)). All phages demonstrated susceptibility to degradation by heat-labile substances, as heat treatment reduced the decay rates to about 0.5 to 2.0% h(sup-1) in the dark. Filtration reduced decay rates by various amounts, averaging 20%. Heat-labile, high-molecular-weight dissolved material (>30 kDa, probably enzymes) appeared responsible for about 1/5 of the maximal decay. Solar radiation was responsible for about 1/3 to 2/3 of the maximal decay of nonnative viruses and about 1/4 to 1/3 of that of the native viruses, suggesting evolutionary adaptation to local light levels. Our results suggest that sunlight is an important contributing factor to virus decay but also point to the significance of particles and dissolved substances in seawater

  17. The influence of auxiliary codopants on persistent phosphor Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+},R{sup 3+} (R = Y, La, Ce, Gd, Tb and Lu)

    SciTech Connect

    Ju, Guifang; Hu, Yihua Chen, Li; Wang, Xiaojuan; Mu, Zhongfei

    2013-11-15

    Graphical abstract: Rare earth ions which close to the line are good codopants. - Highlights: • The persistent luminescence in Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+},R{sup 3+} was reported. • Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+},Lu{sup 3+} shows the best performance. • The influence of auxiliary codopants was discussed in terms of ionic potential and ionic radius. - Abstract: We investigate the persistent luminescence in europium-doped strontium pyrophosphate upon codoping with auxiliary rare earth ions. The persistent phosphors are synthesized via solid-state reaction method under flowing N{sub 2} + H{sub 2}. Under UV irradiation, broadband emission persistent luminescence located at 420 nm is observed in all of these phosphors at room temperature. The effects of auxiliary rare earth ions on Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+} are discussed according to the decay curves and thermoluminescence spectra. Sr{sub 2}P{sub 2}O{sub 7}:Eu{sup 2+},Lu{sup 3+} shows the best performance, while and La{sup 3+} and Ce{sup 3+} codoped samples are the weakest. The influence of auxiliary codopants is discussed in terms of ionic potential and ionic radius. We derive an empirical formula based on the experimental results.

  18. Surface-deposition and distribution of the radon-decay products indoors.

    PubMed

    Espinosa, G; Tommasino, L

    2015-05-01

    The exposure to radon-decay products is of great concern both in dwellings and workplaces. The model to estimate the lung dose refers to the deposition mechanisms and particle sizes. Unfortunately, most of the dose data available are based on the measurement of radon concentration and the concentration of radon decay products. These combined measurements are widely used in spite of the fact that accurate dose assessments require information on the particle deposition mechanisms and the spatial distribution of radon decay products indoors. Most of the airborne particles and/or radon decay products are deposited onto indoor surfaces, which deposition makes the radon decay products unavailable for inhalation. These deposition processes, if properly known, could be successfully exploited to reduce the exposure to radon decay products. In spite of the importance of the surface deposition of the radon decay products, both for the correct evaluation of the dose and for reducing the exposure; little or no efforts have been made to investigate these deposition processes. Recently, two parallel investigations have been carried out in Rome and at Universidad Nacional Autónoma de México (UNAM) in Mexico City respectively, which address the issue of the surface-deposited radon decay products. Even though these investigations have been carried independently, they complement one another. It is with these considerations in mind that it was decided to report both investigations in the same paper. PMID:25748340

  19. Surface-deposition and Distribution of the Radon (222Rn and 220Rn) Decay Products Indoors

    NASA Astrophysics Data System (ADS)

    Espinosa, G.; Tommasino, Luigi

    The exposure to radon (222Rn and 220Rn) decay products is of great concern both in dwellings and workplaces. The model to estimate the lung dose refers to the deposition mechanisms and particle sizes. Unfortunately, most of the dose data available are based on the measurement of radon concentration and the concentration of radon decay products. These combined measurements are widely used in spite of the fact that accurate dose assessments require information on the particle deposition mechanisms and the spatial distribution of radon decay products indoors. Most of the airborne particles and/or radon decay products are deposited onto indoor surfaces, which deposition makes the radon decay products unavailable for inhalation. These deposition processes, if properly known, could be successfully exploited to reduce the exposure to radon decay products. In spite of the importance of the surface deposition of the radon decay products, both for the correct evaluation of the dose and for reducing the exposure, little or no efforts have been made to investigate these deposition processes. Recently, two parallel investigations have been carried out in Rome and at Universidad Nacional Autónoma de México (UNAM) in Mexico City respectively, which address the issue of the surface-deposited radon decay products. Even though these investigations have been carried independently, they complement one another. It is with these considerations in mind that it was decided to report both investigations in the same paper.

  20. Surface-deposition and distribution of the radon-decay products indoors.

    PubMed

    Espinosa, G; Tommasino, L

    2015-05-01

    The exposure to radon-decay products is of great concern both in dwellings and workplaces. The model to estimate the lung dose refers to the deposition mechanisms and particle sizes. Unfortunately, most of the dose data available are based on the measurement of radon concentration and the concentration of radon decay products. These combined measurements are widely used in spite of the fact that accurate dose assessments require information on the particle deposition mechanisms and the spatial distribution of radon decay products indoors. Most of the airborne particles and/or radon decay products are deposited onto indoor surfaces, which deposition makes the radon decay products unavailable for inhalation. These deposition processes, if properly known, could be successfully exploited to reduce the exposure to radon decay products. In spite of the importance of the surface deposition of the radon decay products, both for the correct evaluation of the dose and for reducing the exposure; little or no efforts have been made to investigate these deposition processes. Recently, two parallel investigations have been carried out in Rome and at Universidad Nacional Autónoma de México (UNAM) in Mexico City respectively, which address the issue of the surface-deposited radon decay products. Even though these investigations have been carried independently, they complement one another. It is with these considerations in mind that it was decided to report both investigations in the same paper.