Science.gov

Sample records for 2x2 factorial design

  1. Web-based cognitive bias modification for problem drinkers: protocol of a randomised controlled trial with a 2x2x2 factorial design

    PubMed Central

    2013-01-01

    Background The automatic tendency to attend to, positively evaluate and approach alcohol related stimuli has been found to play a causal role in problematic alcohol use and can be retrained by computerised Cognitive Bias Modification (CBM). In spite of CBMs potential as an internet intervention, little is known about the efficacy of web-based CBM. The study described in this protocol will test the effectiveness of web-based CBM in a double blind randomised controlled trial with a 2 (attention bias retraining: real versus placebo) x 2 (alcohol/no-go training: real versus placebo) x 2 (approach bias retraining: real versus placebo) factorial design. Methods/design The effectiveness of 12 sessions of CBM will be examined among problem drinkers aged 18–65 who are randomly assigned to one of the eight CBM conditions, after completing two modules of a validated cognitive behavioural intervention, DrinkingLess. The primary outcome measure is the change in alcohol use. It is expected that, for each of the CBM interventions, participants in the real CBM conditions will show a greater decrease in alcohol use than participants in the placebo conditions. Secondary outcome measures include the percentage of participants drinking within the limits for sensible drinking. Possible mediating (change in automatic biases) and moderating (working memory, inhibition) factors will be examined, as will the comparative cost-effectiveness of the various CBM strategies. Discussion This study will be the first to test the relative efficacy of various web-based CBM strategies in problem drinkers. If proven effective, CBM could be implemented as a low-cost, low-threshold adjuvant to CBT-based online interventions for problem drinkers. Trial registration Netherlands Trial register: NTR3875. PMID:23870532

  2. Factorial study of rain garden design for nitrogen removal

    EPA Science Inventory

    Abstract Nitrate (〖NO〗_3^--N ) removal studies in bioretention systems showed great variability in removal rates and in some cases 〖NO〗_3^--N was exported. A 3-way factorial design (2 x 2 x 4) was devised for eight outdoor un-vegetated rain gardens to evaluate the effects of ...

  3. Multiple Segment Factorial Vignette Designs

    ERIC Educational Resources Information Center

    Ganong, Lawrence H.; Coleman, Marilyn

    2006-01-01

    The multiple segment factorial vignette design (MSFV) combines elements of experimental designs and probability sampling with the inductive, exploratory approach of qualitative research. MSFVs allow researchers to investigate topics that may be hard to study because of ethical or logistical concerns. Participants are presented with short stories…

  4. Apiary B Factory lattice design

    SciTech Connect

    Donald, M.H.R. ); Garren, A.A. )

    1991-04-01

    The Apiary B Factory is a proposed high-intensity electron-positron collider. This paper will present the lattice design for this facility, which envisions two rings with unequal energies in the PEP tunnel. The design has many interesting optical and geometrical features due to the needs to conform to the existing tunnel, and to achieve the necessary emittances, damping times and vacuum. Existing hardware is used to a maximum extent. 8 figs. 1 tab.

  5. Apiary B Factory Lattice Design

    SciTech Connect

    Donald, M.H.R.; Garren, A.A.

    1991-05-03

    The Apiary B Factory is a proposed high-intensity electron-positron collider. This paper presents the lattice design for this facility, which envisions two rings with unequal energies in the PEP tunnel. The design has many interesting optical and geometrical features due to the needs to conform to the existing tunnel, and to achieve the necessary emittances, damping times and vacuum. Existing hardware is used to a maximum extent.

  6. Computer-aided design of AD 2 X 2 intermetallics with a ThCr2Si2-type of crystal structure

    NASA Astrophysics Data System (ADS)

    Kiselyova, N. N.; Sen'ko, O. V.; Kropotov, D. A.; Dokukin, A. A.

    2012-07-01

    Several hundred new AD 2 X 2 ( A and D are various elements; X = B, Al, Si, P, Ga, Ge, As, Sn, Sb) compounds are computer designed, and the types of their crystal structures under normal conditions are predicted. A special software package is used for the calculations; it includes a set of databases on the properties of inorganic substances and materials and a system for an analysis of these data, which is based on precedent pattern recognition methods. Only data on the properties of the elements entering into the compound compositions are used to predict unknown compounds. The parameters of elements in positions A and D (i.e., the Mendeleev-Pettifor numbers, the pseudopotential radii, and their algebraic functions) are found to mainly determine the possibility of formation of AD 2 X 2 compounds and the type of their crystal structures. New compounds of AD 2B2, AD 2Ga2, and AD 2Sn2 compositions are predicted for the first time.

  7. B-Factory Interaction Region Design

    NASA Astrophysics Data System (ADS)

    Sullivan, M.

    1997-05-01

    High luminosity B factories are generally high current (1-3 A) e^+e^- storage ring accelerators that operate at a center-of-mass energy equal to the mass of the Υ4S resonance (10.58 GeV). The high beam currents are achieved by storing a large number of bunches (several hundred to several thousand) into each beam. Two designs, the ones located at SLAC and KEK, also have asymmetric beam energies. This imparts a boost to the nearly stationary B mesons formed from the decay of the Υ4S and allows precision vertex tracking detectors to look for a difference between the decay profiles of the matter and anti-matter B mesons thereby observing a violation of CP. Bringing these stored beams into collision is one of the major challenges of any B factory design. In order to achieve high luminosity the beams must be tightly focused. This pushes the final focusing elements close enough to the interaction point to be inside the solenoidal field of the physics detector. In addition, beam related detector backgrounds from synchrotron radiation and scattered beam particles must be kept below an acceptable level. The major B factory designs at Cornell University, KEK, and SLAC have all addressed these problems in various ways that depend on specific accelerator design decisions. This presentation will describe the accelerator choices that affect the interaction region design of a B factory and discuss how the above designs address the challenges posed by a high luminosity B factory.

  8. Self-assembly of ligands designed for the building of a new type of [2 x 2] metallic grid. anion encapsulation and diffusion NMR spectroscopy.

    PubMed

    Manzano, Blanca R; Jalón, Félix A; Ortiz, Isabel M; Soriano, M Laura; Torre, Felipe Gómez de la; Elguero, José; Maestro, Miguel A; Mereiter, Kurt; Claridge, Tim D W

    2008-01-21

    The ligands 4,6-bis(pyrazol-1-yl)pyrimidine (bpzpm), 4,6-bis(3,5-dimethylpyrazol-1-yl)pyrimidine (bpz(*)pm), 4,6-bis(4-methylpyrazol-1-yl)pyrimidine (Mebpzpm), and 3,6-bis(3,5-dimethylpyrazol-1-yl)pyridazine (ppdMe) were synthesized and were made to react with Cu(I) centers in the presence of different counteranions. Different [2 x 2] metallic grids were obtained. With ligands bpzpm, bpz*pm, and Mebpzpm, a new type of grid was obtained where the facing ligands were divergent and two counteranions (BF(4-) or PF(6-)) were hosted in the resulting cavities and exhibit C-H...F and anion...pi interactions in the solid state. The presence of methyl groups on the pyrazolyl rings induced several distortions in the structure. In complexes with the ligand ppdMe, there were found two groups of parallel ligands in the grid, and the cavities generated were smaller. The counteranions were situated outside the grid, and the facing ligands exhibited aromatic pi-pi stacking interactions. Anion-pi interactions involving the pyridazine ring were found. The behavior in solution of the new derivatives with a special emphasis on the cation-anion interactions was studied by UV-vis and NMR spectroscopy. Diffusion NMR experiments performed for some complexes allowed us to conclude that weak cation-anion interactions exist in solution, with the counteranions undergoing fast exchange on the diffusion time scale between the free and ion-paired states.

  9. The International Design Study for the Neutrino Factory

    SciTech Connect

    Long, K.

    2008-02-21

    The International Design Study for a future Neutrino Factory and super-beam facility (the ISS) established the physics case for a high-precision programme of long-baseline neutrino-oscillation measurements. The ISS also identified baseline specifications for the Neutrino Factory accelerator complex and the neutrino detector systems. This paper summarises the objectives of the International Design Study for the Neutrino Factory (the IDS-NF). The IDS-NF will build on the work of the ISS to deliver a Reference Design Report for the Neutrino Factory by 2012/13 and an Interim Design Report by 2010/11.

  10. Attentional Performance in Children and Adolescents with Tic Disorder and Co-Occurring Attention-Deficit/hyperactivity Disorder: New Insights from a 2 x 2 Factorial Design Study

    ERIC Educational Resources Information Center

    Greimel, Ellen; Wanderer, Sina; Rothenberger, Aribert; Herpertz-Dahlmann, Beate; Konrad, Kerstin; Roessner, Veit

    2011-01-01

    The aim of the present study was to investigate the effect of both tic disorder (TD) and attention-deficit/hyperactivity disorder (ADHD) on attentional functions. N = 96 children and adolescents participated in the study, including n = 21 subjects with TD, n = 23 subjects with ADHD, n = 25 subjects with TD+ADHD, and n = 27 controls. Attentional…

  11. A cost-Effective Design for a Neutrino Factory

    SciTech Connect

    Berg, J.S.; Bogacz, S.A.; Caspi, S.; Cobb, J.; Fernow, R.C.; Gallardo, J.C.; Kahn, S.; Kirk, H.; Neuffer, D.; Palmer, R.; Paul, K.; Witte, H.; Zisman, M.

    2006-06-01

    There have been active efforts in the U.S., Europe, and Japan on the design of a Neutrino Factory. This type of facility produces intense beams of neutrinos from the decay of muons in a high energy storage ring. In the U.S., a second detailed Feasibility Study (FS2) for a Neutrino Factory was completed in 2001. Since that report was published, new ideas in bunching, cooling and acceleration of muon beams have been developed. We have incorporated these ideas into a new facility design, which we designate as Study 2B (ST2B), that should lead to significant cost savings over the FS2 design.

  12. Cost-effective design for a neutrino factory

    SciTech Connect

    Alex Bogacz

    2006-01-01

    There have been active efforts in the U.S., Europe, and Japan on the design of a neutrino factory. This type of facility produces intense beams of neutrinos from the decay of muons in a high-energy storage ring. In the U.S., a second detailed feasibility study (FS2) for a neutrino factory was completed in 2001. Since that report was published, new ideas in bunching, cooling, and acceleration of muon beams have been developed. We have incorporated these ideas into a new facility design, which we designate as study 2B (ST2B), that should lead to significant cost savings over the FS2 design.

  13. Status of the International Design Study of the Neutrino Factory

    SciTech Connect

    Long, Kenneth

    2010-03-30

    The International Design Study for the Neutrino Factory (the IDS-NF) has been established by the Neutrino Factory community to deliver the Reference Design Report (RDR) for the facility by 2012. The baseline design for the facility, developed from that defined in the International Scoping Study of a future Neutrino Factory and super-beam facility (the ISS), will provide 10{sup 21} muon decays per year from 25 GeV stored muon beams. The facility will serve two neutrino detectors; one situated at source-detector distance of between 3000-5000 km, the second at 7000-8000 km. The baseline design for the facility will be described and the status of the IDS-NF effort will be summarised.

  14. Factorial Design: An Eight Factor Experiment Using Paper Helicopters

    NASA Technical Reports Server (NTRS)

    Kozma, Michael

    1996-01-01

    The goal of this paper is to present the analysis of the multi-factor experiment (factorial design) conducted in EG490, Junior Design at Loyola College in Maryland. The discussion of this paper concludes the experimental analysis and ties the individual class papers together.

  15. Bioretention Systems: Partial Factorial Designs for Nitrate Removal

    EPA Science Inventory

    Changes in nutrient loadings are monitored by introducing captured stormwater runoff into eight outdoor rain gardens at EPA’s Urban Water Research Facility in Edison, New Jersey scaled for residential and urban landscapes. The partial factorial design includes non-vegetated meso...

  16. Error Rates of Multiple F Tests in Factorial ANOVA Designs.

    ERIC Educational Resources Information Center

    Halderson, Judith S.; Glasnapp, Douglas R.

    The primary purpose of the present study was to investigate empirically the effect of multiple hypothesis testing on error rates in factorial ANOVA designs under a variety of controlled conditions. The per comparison, per experiment, and experimentwise error rates were investigated for three hypothesis testing procedures. The specific conditions…

  17. Systems analysis and futuristic designs of advanced biofuel factory concepts.

    SciTech Connect

    Chianelli, Russ; Leathers, James; Thoma, Steven George; Celina, Mathias Christopher; Gupta, Vipin P.

    2007-10-01

    The U.S. is addicted to petroleum--a dependency that periodically shocks the economy, compromises national security, and adversely affects the environment. If liquid fuels remain the main energy source for U.S. transportation for the foreseeable future, the system solution is the production of new liquid fuels that can directly displace diesel and gasoline. This study focuses on advanced concepts for biofuel factory production, describing three design concepts: biopetroleum, biodiesel, and higher alcohols. A general schematic is illustrated for each concept with technical description and analysis for each factory design. Looking beyond current biofuel pursuits by industry, this study explores unconventional feedstocks (e.g., extremophiles), out-of-favor reaction processes (e.g., radiation-induced catalytic cracking), and production of new fuel sources traditionally deemed undesirable (e.g., fusel oils). These concepts lay the foundation and path for future basic science and applied engineering to displace petroleum as a transportation energy source for good.

  18. Evolutionary algorithm for the neutrino factory front end design

    SciTech Connect

    Poklonskiy, Alexey A.; Neuffer, David; /Fermilab

    2009-01-01

    The Neutrino Factory is an important tool in the long-term neutrino physics program. Substantial effort is put internationally into designing this facility in order to achieve desired performance within the allotted budget. This accelerator is a secondary beam machine: neutrinos are produced by means of the decay of muons. Muons, in turn, are produced by the decay of pions, produced by hitting the target by a beam of accelerated protons suitable for acceleration. Due to the physics of this process, extra conditioning of the pion beam coming from the target is needed in order to effectively perform subsequent acceleration. The subsystem of the Neutrino Factory that performs this conditioning is called Front End, its main performance characteristic is the number of the produced muons.

  19. Factorial Design to Optimize Biosurfactant Production by Yarrowia lipolytica

    PubMed Central

    Fontes, Gizele Cardoso; Fonseca Amaral, Priscilla Filomena; Nele, Marcio; Zarur Coelho, Maria Alice

    2010-01-01

    In order to improve biosurfactant production by Yarrowia lipolytica IMUFRJ 50682, a factorial design was carried out. A 24 full factorial design was used to investigate the effects of nitrogen sources (urea, ammonium sulfate, yeast extract, and peptone) on maximum variation of surface tension (ΔST) and emulsification index (EI). The best results (67.7% of EI and 20.9 mN m−1 of ΔST) were obtained in a medium composed of 10 g 1−1 of ammonium sulfate and 0.5 g 1−1 of yeast extract. Then, the effects of carbon sources (glycerol, hexadecane, olive oil, and glucose) were evaluated. The most favorable medium for biosurfactant production was composed of both glucose (4% w/v) and glycerol (2% w/v), which provided an EI of 81.3% and a ΔST of 19.5 mN m−1. The experimental design optimization enhanced ΔEI by 110.7% and ΔST by 108.1% in relation to the standard process. PMID:20368788

  20. Factor Structure and Predictive Utility of the 2 x 2 Achievement Goal Model in a Sample of Taiwan Students

    ERIC Educational Resources Information Center

    Chiang, Yu-Tzu; Yeh, Yu-Chen; Lin, Sunny S. J.; Hwang, Fang-Ming

    2011-01-01

    This study examined structure and predictive utility of the 2 x 2 achievement goal model among Taiwan pre-university school students (ages 10 to 16) who learned Chinese language arts. The confirmatory factor analyses of Achievement Goal Questionnaire-Chinese version provided good fitting between the factorial and dimensional structures with the…

  1. Optimization of minoxidil microemulsions using fractional factorial design approach.

    PubMed

    Jaipakdee, Napaphak; Limpongsa, Ekapol; Pongjanyakul, Thaned

    2016-01-01

    The objective of this study was to apply fractional factorial and multi-response optimization designs using desirability function approach for developing topical microemulsions. Minoxidil (MX) was used as a model drug. Limonene was used as an oil phase. Based on solubility, Tween 20 and caprylocaproyl polyoxyl-8 glycerides were selected as surfactants, propylene glycol and ethanol were selected as co-solvent in aqueous phase. Experiments were performed according to a two-level fractional factorial design to evaluate the effects of independent variables: Tween 20 concentration in surfactant system (X1), surfactant concentration (X2), ethanol concentration in co-solvent system (X3), limonene concentration (X4) on MX solubility (Y1), permeation flux (Y2), lag time (Y3), deposition (Y4) of MX microemulsions. It was found that Y1 increased with increasing X3 and decreasing X2, X4; whereas Y2 increased with decreasing X1, X2 and increasing X3. While Y3 was not affected by these variables, Y4 increased with decreasing X1, X2. Three regression equations were obtained and calculated for predicted values of responses Y1, Y2 and Y4. The predicted values matched experimental values reasonably well with high determination coefficient. By using optimal desirability function, optimized microemulsion demonstrating the highest MX solubility, permeation flux and skin deposition was confirmed as low level of X1, X2 and X4 but high level of X3. PMID:25318551

  2. FFAG Designs for the International Design Study for the Neutrino Factory

    SciTech Connect

    Berg, J.S.; Machida, S.

    2009-05-04

    The International Design Study for the Neutrino Factory (IDS-NF) aims to produce a design report for a neutrino factory. One component of that design is a linear nonscaling fixed-field alternating gradient accelerator (FFAG) that will accelerate to the final energy of 25 GeV. An FFAG is used to reduce the machine cost by maximizing the number of passes made through the RF cavities. We present some design options for this FFAG, individually optimized for cost. We study the addition of nonlinear magnets to the lattice to improve the performance of the lattice and consider the negative effects of doing so.

  3. The Skateboard Factory: Curriculum by Design--Oasis Skateboard Factory Q&A with Craig Morrison

    ERIC Educational Resources Information Center

    Pearson, George

    2012-01-01

    Since its opening three years ago, Oasis Skateboard Factory (OSF), founded by teacher Craig Morrison, has attracted considerable media exposure and received a Ken Spencer Award from the CEA for its innovative program. OSF is one of three programs offered by Oasis Alternative Secondary School, one of 22 alternative secondary schools of the Toronto…

  4. PEP-II: An asymmetric B factory. Conceptual design report

    SciTech Connect

    Not Available

    1993-06-01

    In this report, the authors have described an updated conceptual design for the high-luminosity Asymmetric B Factory (PEP-II) to be built in the PEP tunnel culmination of more than four years of effort aimed at the design and construction of an asymmetric e{sub +}e{sub {minus}} collider capable of achieving a luminosity of L = 3 {times} 10{sup 33} cm{sup {minus}2} s{sup {minus}1}. All aspects of the conceptual design were scrutinized in March 1991 by a DOE technical review committee chaired by Dr. L. Edward Temple. The design was deemed feasible and capable of achieving its physics goals. Furthermore, the cost estimate, schedule, and management plan for the project were fully endorsed by the committee. This updated conceptual design report captures the technical progress since the March 1991 review and reflects the lower cost estimate corresponding to the improved design. Although the PEP-II design has continued to evolve, no technical scope changes have been made that invalidate the conclusion of the DOE review. The configuration adopted utilizes two storage rings, an electron ring operating at 9 GeV and a positron ring at 3.1 GeV, each with a circumference of 2200 m. The high-energy ring is an upgrade of the PEP storage ring at SLAC; all PEP magnets and most power supplies will be reused. The upgrade consists primarily of replacing the PEP vacuum chamber and RF system with newly designed versions optimized for the high-current environment of PEP-II. The low-energy ring will be newly constructed and will be situated atop the high-energy ring in the PEP tunnel. Utilities already installed in the PEP tunnel are largely sufficient to operate the two PEP-II storage rings.

  5. Credit WCT. Original 2'" x 2'" color negative is housed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 2-'" x 2-'" color negative is housed in the JPL Photography Laboratory, Pasadena, California. View shows small autoclave demonstrated by JPL staff member Milton Clay (JPL negative no. JPL-10286AC, 27 January 1989). - Jet Propulsion Laboratory Edwards Facility, Liner Laboratory, Edwards Air Force Base, Boron, Kern County, CA

  6. Credit WCT. Original 2'" x 2%" color negative is housed ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Credit WCT. Original 2-'" x 2-%" color negative is housed in the JPL Photography Laboratory, Pasadena, California. This view shows the propellant cutter as it was originally installed (JPL negative no. 381-2274A, 29 June 1962) - Jet Propulsion Laboratory Edwards Facility, Preparation Building, Edwards Air Force Base, Boron, Kern County, CA

  7. Understanding Student Goal Orientation Tendencies to Predict Student Performance: A 2x2 Achievement Goal Orientation

    ERIC Educational Resources Information Center

    Miller, Mark Alan

    2013-01-01

    The study tested the 2X2 model of the Achievement Goal Orientation (AGO) theory in a military technical training environment while using the Air Force Officers Qualifying Test's academic aptitude score to control for the differences in the students' academic aptitude. The study method was quantitative and the design was correlational.…

  8. Status and Plans for the Accelerator Working Group of the International Design Study of the Neutrino Factory

    SciTech Connect

    Berg, J. Scott

    2010-03-30

    The purpose of the International Design Study of the Neutrino Factory (IDS-NF) is to produce a design report for a neutrino factory in 2013. I report the status of the accelerator design and plans for future studies.

  9. The preparation and evaluation of sustained release suppositories containing ketoprofen and Eudragit RL 100 by using factorial design.

    PubMed

    Ozgüney, I; Ozcan, I; Ertan, G; Güneri, T

    2007-01-01

    The preparation of ketoprofen (KP) sustained release (SR) suppositories was designed according to the 3(2) x 2(1) factorial design as three different KP:Eudragit RL 100 ratios (1:0.5, 1:1, 1:2), three particle sizes of prepared granules (250-500, 500-710, and 710-1000 microm) and two different PEG 400:PEG 6000 ratios (40:60, 50:50). The conventional KP suppositories were also prepared by using Witepsol H 15, Massa Estarinum B, Cremao and the mixture of PEG 400:PEG 6000. The dissolution studies of suppositories prepared were carried out according to the USP XXIII basket method in the phosphate buffer (pH = 7.2) at 50 rpm, and it was shown that the dissolution time was sustained up to 8 hours. According to the results of the factorial design, the most important independent variable on t50 and t80 was drug:polymer ratios. The log of partition coefficient of KP was determined as 1.46, showing the high affinity to the oily phase. n exponent and kinetic studies were conducted to explain diffusion mechanism, and it is understood that if the inert KP:Eudragit RL 100 ratio is increased in the particles, the Fickian difusion dominates and the best kinetic turns to Higuchi from the Hixson-Crowell. There is neither crystalline form of KP nor degradation product in the suppositories detected with the differential scanning calorimetry (DSC) studies. In addition to these studies, antiinflammatory activity of SR suppositories also determined that it was significantly extended according to the conventional suppositories.

  10. Parameters of a Super-B-Factory Design

    SciTech Connect

    Seeman, J.; Cai, Y.; Ecklund, S.; Fox, J.D.; Heifets, S.A.; Li, N.; McIntosh, P.A.; Novokhatski, A.; Sullivan, M.K.; Teytelman, D.; Wienands, U.; Biagini, M.E.; /Frascati

    2006-03-03

    Parameters are being studied for a high luminosity e{sup +}e{sup -} collider operating at the Upsilon 4S that would deliver a luminosity in the range of 7 to 10 x 10{sup 35}/cm{sup 2}/s. Particle physics studies dictate that a much higher luminosity collider than the present B-Factory accelerators will be needed to answer future new key physics questions. The success of the present B-Factories, PEP-II and KEKB, in producing unprecedented luminosity with very short commissioning times has taught us about the accelerator physics of asymmetric e{sup +}e{sup -} colliders in a new parameter regime. Such a collider could produce an integrated luminosity of 10,000 fb{sup -1} (10 ab{sup -1}) in a running year. A Super-B-Factory [1-8] with 30 to 50 times the performance of the present PEP-II accelerator would incorporate a higher frequency RF system, lower impedance vacuum chambers, higher power synchrotron radiation absorbers, and stronger bunch-by-bunch feedback systems. The present injector based on the SLAC linac needs no improvements and is ready for the Super-B-Factory.

  11. Robust Techniques for Testing Heterogeneity of Variance Effects in Factorial Designs.

    ERIC Educational Resources Information Center

    O'Brien, Ralph G.

    1978-01-01

    Several ways of using traditional analysis of variance to test the homogeneity of variance in factorial designs with equal or unequal cell sizes are compared using theoretical and Monte Carlo results. (Author/JKS)

  12. Status of the Tau-Charm Factory Project and aspects of the detector design

    SciTech Connect

    Schindler, R.H.

    1992-10-01

    This paper reviews the status of the Tau-Charm Factory Project being proposed for construction in Spain. The paper also reviews characteristics of the detector design, and the issues surrounding the present choices of technologies.

  13. Gaming in the Classroom: An Innovative Way to Teach Factorial Designs

    ERIC Educational Resources Information Center

    Stansbury, Jessica A.; Munro, Geoffrey D.

    2013-01-01

    This study tested the effectiveness of video game use for instruction of factorial designs in a research methods course. Students designed and conducted a mini study, playing "Dance, Dance, Revolution", using video game scores as the dependent variable. A mixed-design analysis of variance revealed a significantly greater increase from pretest to…

  14. A Preliminary Interaction Region Design for a Super B-Factory

    SciTech Connect

    Sullivan, M.; Donald, M.; Ecklund, S.; Novokhatski, A.; Seeman, J.; Wienands, U.; Biagini, M.; /Frascati

    2005-06-10

    The success of the two B-Factories (PEP-II and KEKB) has encouraged us to look at design parameters for a B-Factory with a 30-50 times increase in the luminosity of the present machines to a luminosity of L {approx} 1 x 10{sup 36} cm{sup -2} sec{sup -1}. We present an initial design of an interaction region for a ''SuperB'' accelerator with a crossing angle of {+-}14 mrad and include a discussion of the constraints, requirements and concerns that go into designing an interaction region for these very high luminosity e{sup +}e{sup -} machines.

  15. Design of experiments with multiple independent variables: a resource management perspective on complete and reduced factorial designs.

    PubMed

    Collins, Linda M; Dziak, John J; Li, Runze

    2009-09-01

    An investigator who plans to conduct an experiment with multiple independent variables must decide whether to use a complete or reduced factorial design. This article advocates a resource management perspective on making this decision, in which the investigator seeks a strategic balance between service to scientific objectives and economy. Considerations in making design decisions include whether research questions are framed as main effects or simple effects; whether and which effects are aliased (confounded) in a particular design; the number of experimental conditions that must be implemented in a particular design and the number of experimental subjects the design requires to maintain the desired level of statistical power; and the costs associated with implementing experimental conditions and obtaining experimental subjects. In this article 4 design options are compared: complete factorial, individual experiments, single factor, and fractional factorial. Complete and fractional factorial designs and single-factor designs are generally more economical than conducting individual experiments on each factor. Although relatively unfamiliar to behavioral scientists, fractional factorial designs merit serious consideration because of their economy and versatility.

  16. A Sino-Finnish Initiative for Experimental Teaching Practices Using the Design Factory Pedagogical Platform

    ERIC Educational Resources Information Center

    Björklund, Tua A.; Nordström, Katrina M.; Clavert, Maria

    2013-01-01

    The paper presents a Sino-Finnish teaching initiative, including the design and experiences of a series of pedagogical workshops implemented at the Aalto-Tongji Design Factory (DF), Shanghai, China, and the experimentation plans collected from the 54 attending professors and teachers. The workshops aimed to encourage trying out interdisciplinary…

  17. Comparison of ANOVA, McSweeney, Bradley, Harwell-Serlin, and Blair-Sawilowsky Tests in the Balanced 2x2x2 Layout.

    ERIC Educational Resources Information Center

    Kelley, D. Lynn; And Others

    The Type I error and power properties of the 2x2x2 analysis of variance (ANOVA) and tests developed by McSweeney (1967), Bradley (1979), Harwell-Serlin (1989; Harwell, 1991), and Blair-Sawilowsky (1990) were compared using Monte Carlo methods. The ANOVA was superior under the Gaussian and uniform distributions. The Blair-Sawilowsky test was…

  18. Neutrino Factories

    NASA Astrophysics Data System (ADS)

    Geer, Steve

    2010-06-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture and accelerate O(1021) muons/year. This development prepares the way for a new type of neutrino source : a Neutrino Factory. This article reviews the motivation, design and R&D for a Neutrino Factory.

  19. Interim Design Report for the International Design Study for a Neutrino Factory

    SciTech Connect

    Choubey, S.; Gandhi, R.; Goswami, S.; Berg, J.S.; Fernow, R.; Gallardo, J.C.; Gupta, R.; Kirk, H.; Simos, N.; Souchlas, N.; Ellis, M.; /Brunel U. /CERN /Durham U., IPPP /Fermilab /Geneva U. /Glasgow U. /Heidelberg, Max Planck Inst. /Imperial Coll., London /Jefferson Lab /Saha Inst.

    2011-10-01

    The starting point for the International Design Study for the Neutrino Factory (the IDS-NF) was the output of the earlier International Scoping Study for a future Neutrino Factory and super-beam facility (the ISS). The accelerator facility described in section 2 incorporates the improvements that have been derived from the substantial amount of work carried out within the Accelerator Working Group. Highlights of these improvements include: (1) Initial concepts for the implementation of the proton driver at each of the three example sites, CERN, FNAL, and RAL; (2) Detailed studies of the energy deposition in the target area; (3) A reduction in the length of the muon beam phase-rotation and bunching systems; (4) Detailed analyses of the impact of the risk that stray magnetic field in the accelerating cavities in the ionization cooling channel will reduce the maximum operating gradient. Several alternative ionization-cooling lattices have been developed as fallback options to mitigate this technical risk; (5) Studies of particle loss in the muon front-end and the development of strategies to mitigate the deleterious effects of such losses; (6) The development of more complete designs for the muon linac and re-circulating linacs; (7) The development of a design for the muon FFAG that incorporates insertions for injection and extraction; and (8) Detailed studies of diagnostics in the decay ring. Other sub-systems have undergone a more 'incremental' evolution; an indication that the design of the Neutrino Factory has achieved a degree of maturity. The design of the neutrino detectors described in section 3 has been optimized and the Detector Working Group has made substantial improvements to the simulation and analysis of the Magnetized Iron Neutrino Detector (MIND) resulting in an improvement in the overall neutrino-detection efficiency and a reduction in the neutrino-energy threshold. In addition, initial consideration of the engineering of the MIND has generated a

  20. A comparison of two factorial designs, a complete 3 x 3 factorial and a central composite rotatable design, for use in binomial response experiments in aquatic toxicology.

    PubMed

    Edginton, Andrea N; Sheridan, Patrick M; Boermans, Herman J; Thompson, Dean G; Holt, John D; Stephenson, Gerald R

    2004-02-01

    Using an amphibian toxicity testing protocol, comparative studies were conducted to assess the predictive precision, degree of similarity of results and efficiency of a central composite rotatable design (CCRD) in relation to a conventional complete 3x3 factorial design. Data were treated with response surface analysis using generalized linear models (glm) and application of profile deviance to generate confidence intervals. Design comparisons were based on studies conducted using the Frog Embryo Teratogenesis Assay-Xenopus (FETAX) protocol to examine the interaction of three toxicants at pH levels ranging from 4.5 to 8.5. Test substances included two commercial herbicide formulations based on glyphosate ([N-phosphonomethyl]glycine) isopropylamine salt (Vision, Rodeo) as well as a polyethoxylated tallow amine surfactant blend (MON 0818), which is a key component of the Vision formulation. The generated models from both the CCRD and the factorial designs produced toxicity estimates similar to each other and to previously published results. Trends were also similar to published results in that the surfactant, MON 0818, was comparatively more toxic than Vision, which was more toxic than Rodeo. Further, all toxicants induced higher mortality under alkaline as opposed to acidic conditions. The CCRD was between 66 and 124% more efficient in the Vision and Rodeo experiments in comparison to the complete 3x3 factorial. Thus, the factorial experiment would have required at least 66% more observations to obtain the same precision. There appeared to be no efficiency gain with the use of the CCRD for MON 0818. The CCRD had tighter confidence intervals in 9 of 12 cases across all test substances. Computer simulations using the experimental data for Vision demonstrated that the LCalpha estimates generated from the 1,000 simulated data sets were very close to the "true" value for both designs. This was based on small bias and mean squared error calculations. Coverage

  1. The future of tau physics and tau-charm detector and factory design

    SciTech Connect

    Perl, M.L.

    1991-02-01

    Future research on the tau lepton requires large statistics, thorough investigation of systematic errors, and direct experimental knowledge of backgrounds. Only a tau-charm factory with a specially designed detector can provide all the experimental conditions to meet these requirements. This paper is a summary of three lectures delivered at the 1991 Lake Louise Winter Institute.

  2. The effect of heterogeneous variance on efficiency and power of cluster randomized trials with a balanced 2 × 2 factorial design.

    PubMed

    Lemme, Francesca; van Breukelen, Gerard J P; Candel, Math J J M; Berger, Martijn P F

    2015-10-01

    Sample size calculation for cluster randomized trials (CRTs) with a [Formula: see text] factorial design is complicated due to the combination of nesting (of individuals within clusters) with crossing (of two treatments). Typically, clusters and individuals are allocated across treatment conditions in a balanced fashion, which is optimal under homogeneity of variance. However, the variance is likely to be heterogeneous if there is a treatment effect. An unbalanced allocation is then more efficient, but impractical because the optimal allocation depends on the unknown variances. Focusing on CRTs with a [Formula: see text] design, this paper addresses two questions: How much efficiency is lost by having a balanced design when the outcome variance is heterogeneous? How large must the sample size be for a balanced allocation to have sufficient power under heterogeneity of variance? We consider different scenarios of heterogeneous variance. Within each scenario, we determine the relative efficiency of a balanced design, as a function of the level (cluster, individual, both) and amount of heterogeneity of the variance. We then provide a simple correction of the sample size for the loss of power due to heterogeneity of variance when a balanced allocation is used. The theory is illustrated with an example of a published 2 x2 CRT.

  3. The effect of heterogeneous variance on efficiency and power of cluster randomized trials with a balanced 2 × 2 factorial design.

    PubMed

    Lemme, Francesca; van Breukelen, Gerard J P; Candel, Math J J M; Berger, Martijn P F

    2015-10-01

    Sample size calculation for cluster randomized trials (CRTs) with a [Formula: see text] factorial design is complicated due to the combination of nesting (of individuals within clusters) with crossing (of two treatments). Typically, clusters and individuals are allocated across treatment conditions in a balanced fashion, which is optimal under homogeneity of variance. However, the variance is likely to be heterogeneous if there is a treatment effect. An unbalanced allocation is then more efficient, but impractical because the optimal allocation depends on the unknown variances. Focusing on CRTs with a [Formula: see text] design, this paper addresses two questions: How much efficiency is lost by having a balanced design when the outcome variance is heterogeneous? How large must the sample size be for a balanced allocation to have sufficient power under heterogeneity of variance? We consider different scenarios of heterogeneous variance. Within each scenario, we determine the relative efficiency of a balanced design, as a function of the level (cluster, individual, both) and amount of heterogeneity of the variance. We then provide a simple correction of the sample size for the loss of power due to heterogeneity of variance when a balanced allocation is used. The theory is illustrated with an example of a published 2 x2 CRT. PMID:25911332

  4. Redirector: Designing Cell Factories by Reconstructing the Metabolic Objective

    PubMed Central

    Church, George M.

    2013-01-01

    Advances in computational metabolic optimization are required to realize the full potential of new in vivo metabolic engineering technologies by bridging the gap between computational design and strain development. We present Redirector, a new Flux Balance Analysis-based framework for identifying engineering targets to optimize metabolite production in complex pathways. Previous optimization frameworks have modeled metabolic alterations as directly controlling fluxes by setting particular flux bounds. Redirector develops a more biologically relevant approach, modeling metabolic alterations as changes in the balance of metabolic objectives in the system. This framework iteratively selects enzyme targets, adds the associated reaction fluxes to the metabolic objective, thereby incentivizing flux towards the production of a metabolite of interest. These adjustments to the objective act in competition with cellular growth and represent up-regulation and down-regulation of enzyme mediated reactions. Using the iAF1260 E. coli metabolic network model for optimization of fatty acid production as a test case, Redirector generates designs with as many as 39 simultaneous and 111 unique engineering targets. These designs discover proven in vivo targets, novel supporting pathways and relevant interdependencies, many of which cannot be predicted by other methods. Redirector is available as open and free software, scalable to computational resources, and powerful enough to find all known enzyme targets for fatty acid production. PMID:23341769

  5. Using Bayesian variable selection to analyze regular resolution IV two-level fractional factorial designs

    DOE PAGES

    Chipman, Hugh A.; Hamada, Michael S.

    2016-06-02

    Regular two-level fractional factorial designs have complete aliasing in which the associated columns of multiple effects are identical. Here, we show how Bayesian variable selection can be used to analyze experiments that use such designs. In addition to sparsity and hierarchy, Bayesian variable selection naturally incorporates heredity . This prior information is used to identify the most likely combinations of active terms. We also demonstrate the method on simulated and real experiments.

  6. Design of Experiments with Multiple Independent Variables: A Resource Management Perspective on Complete and Reduced Factorial Designs

    ERIC Educational Resources Information Center

    Collins, Linda M.; Dziak, John J.; Li, Runze

    2009-01-01

    An investigator who plans to conduct an experiment with multiple independent variables must decide whether to use a complete or reduced factorial design. This article advocates a resource management perspective on making this decision, in which the investigator seeks a strategic balance between service to scientific objectives and economy.…

  7. An analysis of network reciprocity in Prisoner's Dilemma games using Full Factorial Designs of Experiment.

    PubMed

    Yamauchi, Atsuo; Tanimoto, Jun; Hagishima, Aya

    2011-01-01

    Despite hundreds of studies on the Prisoner's Dilemma (PD) game, understanding about network reciprocity remains a unsolved puzzle. Thus, we performed a series of Full Factorial Design of Experiments (FFDOE) to evaluate what dominates emerging cooperation in the PD game on various networks. The results qualitatively reveal the influence of each factor and show that some combinations of factors have complicated interactions. Remarkably, the choice of strategy update rule or update dynamics is much more important than the type of network imposed or, at least, the factorial effect of the average degree of the network reported by Nowak (Science 314, 5805, 1560-1563, 2006) and Ohtsuki et al. (Nature 441, 502-505, 2006). Furthermore, the decision of which PD game type to investigate (whether all PD games, PD-Chicken boundary games or Donor & Recipient games) is important for discussing network reciprocity.

  8. Assessing factorial invariance of two-way rating designs using three-way methods

    PubMed Central

    Kroonenberg, Pieter M.

    2015-01-01

    Assessing the factorial invariance of two-way rating designs such as ratings of concepts on several scales by different groups can be carried out with three-way models such as the Parafac and Tucker models. By their definitions these models are double-metric factorially invariant. The differences between these models lie in their handling of the links between the concept and scale spaces. These links may consist of unrestricted linking (Tucker2 model), invariant component covariances but variable variances per group and per component (Parafac model), zero covariances and variances different per group but not per component (Replicated Tucker3 model) and strict invariance (Component analysis on the average matrix). This hierarchy of invariant models, and the procedures by which to evaluate the models against each other, is illustrated in some detail with an international data set from attachment theory. PMID:25620936

  9. Sensitivity Analysis of the Thermal Response of 9975 Packaging Using Factorial Design Methods

    SciTech Connect

    Gupta, Narendra K.

    2005-10-31

    A method is presented for using the statistical design of experiment (2{sup k} Factorial Design) technique in the sensitivity analysis of the thermal response (temperature) of the 9975 radioactive material packaging where multiple thermal properties of the impact absorbing and fire insulating material Celotex and certain boundary conditions are subject to uncertainty. 2{sup k} Factorial Design method is very efficient in the use of available data and is capable of analyzing the impact of main variables (Factors) and their interactions on the component design. The 9975 design is based on detailed finite element (FE) analyses and extensive proof testing to meet the design requirements given in 10CFR71 [1]. However, the FE analyses use Celotex thermal properties that are based on published data and limited experiments. Celotex is an orthotropic material that is used in the home building industry. Its thermal properties are prone to variation due to manufacturing and fabrication processes, and due to long environmental exposure. This paper will evaluate the sensitivity of variations in thermal conductivity of the Celotex, convection coefficient at the drum surface, and drum emissivity (herein called Factors) on the thermal response of 9975 packaging under Normal Conditions of Transport (NCT). Application of this methodology will ascertain the robustness of the 9975 design and it can lead to more specific and useful understanding of the effects of various Factors on 9975 performance.

  10. Flexible subunit stoichiometry of functional human P2X2/3 heteromeric receptors.

    PubMed

    Kowalski, Maria; Hausmann, Ralf; Schmid, Julia; Dopychai, Anke; Stephan, Gabriele; Tang, Yong; Schmalzing, Günther; Illes, Peter; Rubini, Patrizia

    2015-12-01

    The aim of the present work was to clarify whether heterotrimeric P2X2/3 receptors have a fixed subunit stoichiometry consisting of one P2X2 and two P2X3 subunits as previously suggested, or a flexible stoichiometry containing also the inverse subunit composition. For this purpose we transfected HEK293 cells with P2X2 and P2X3 encoding cDNA at the ratios of 1:2 and 4:1, and analysed the biophysical and pharmacological properties of the generated receptors by means of the whole-cell patch-clamp technique. The concentration-response curves for the selective agonist α,β-meATP did not differ from each other under the two transfection ratios. However, co-expression of an inactive P2X2 mutant and the wild type P2X3 subunit and vice versa resulted in characteristic distortions of the α,β-meATP concentration-response relationships, depending on which subunit was expressed in excess, suggesting that HEK293 cells express mixtures of (P2X2)1/(P2X3)2 and (P2X2)2/(P2X3)1 receptors. Whereas the allosteric modulators H+ and Zn2+ failed to discriminate between the two possible heterotrimeric receptor variants, the α,β-meATP-induced responses were blocked more potently by the competitive antagonist A317491, when the P2X2 subunit was expressed in deficit of the P2X3 subunit. Furthermore, blue-native PAGE analysis of P2X2 and P2X3 subunits co-expressed in Xenopus laevis oocytes and HEK293 cells revealed that plasma membrane-bound P2X2/3 receptors appeared in two clearly distinct heterotrimeric complexes: a (P2X2-GFP)2/(P2X3)1 complex and a (P2X2-GFP)1/(P2X3)2 complex. These data strongly indicate that the stoichiometry of the heteromeric P2X2/3 receptor is not fixed, but determined in a permutational manner by the relative availability of P2X2 and P2X3 subunits. PMID:26184350

  11. Flexible subunit stoichiometry of functional human P2X2/3 heteromeric receptors.

    PubMed

    Kowalski, Maria; Hausmann, Ralf; Schmid, Julia; Dopychai, Anke; Stephan, Gabriele; Tang, Yong; Schmalzing, Günther; Illes, Peter; Rubini, Patrizia

    2015-12-01

    The aim of the present work was to clarify whether heterotrimeric P2X2/3 receptors have a fixed subunit stoichiometry consisting of one P2X2 and two P2X3 subunits as previously suggested, or a flexible stoichiometry containing also the inverse subunit composition. For this purpose we transfected HEK293 cells with P2X2 and P2X3 encoding cDNA at the ratios of 1:2 and 4:1, and analysed the biophysical and pharmacological properties of the generated receptors by means of the whole-cell patch-clamp technique. The concentration-response curves for the selective agonist α,β-meATP did not differ from each other under the two transfection ratios. However, co-expression of an inactive P2X2 mutant and the wild type P2X3 subunit and vice versa resulted in characteristic distortions of the α,β-meATP concentration-response relationships, depending on which subunit was expressed in excess, suggesting that HEK293 cells express mixtures of (P2X2)1/(P2X3)2 and (P2X2)2/(P2X3)1 receptors. Whereas the allosteric modulators H+ and Zn2+ failed to discriminate between the two possible heterotrimeric receptor variants, the α,β-meATP-induced responses were blocked more potently by the competitive antagonist A317491, when the P2X2 subunit was expressed in deficit of the P2X3 subunit. Furthermore, blue-native PAGE analysis of P2X2 and P2X3 subunits co-expressed in Xenopus laevis oocytes and HEK293 cells revealed that plasma membrane-bound P2X2/3 receptors appeared in two clearly distinct heterotrimeric complexes: a (P2X2-GFP)2/(P2X3)1 complex and a (P2X2-GFP)1/(P2X3)2 complex. These data strongly indicate that the stoichiometry of the heteromeric P2X2/3 receptor is not fixed, but determined in a permutational manner by the relative availability of P2X2 and P2X3 subunits.

  12. Regulation of P2X2 Receptors by the Neuronal Calcium Sensor VILIP1

    PubMed Central

    Chaumont, Severine; Compan, Vincent; Toulme, Estelle; Richler, Esther; Housley, Gary D.; Rassendren, Francois; Khakh, Baljit S.

    2012-01-01

    Extracellular adenosine triphosphate (ATP) activates P2X receptors, which are involved in diverse physiological functions. Using a proteomic approach, we identified the neuronal calcium sensor VILIP1 as interacting with P2X2 receptors. We found that VILIP1 forms a signaling complex in vitro and in vivo with P2X2 receptors and regulates P2X2 receptor sensitivity to ATP, peak response, surface expression, and diffusion. VILIP1 constitutively binds to P2X2 receptors and displays enhanced interactions in an activation- and calcium-dependent manner owing to exposure of its binding segment in P2X2 receptors. VILIP1-P2X2 interactions are also enhanced in hippocampal neurons during conditions of action potential firing known to trigger P2X2 receptor activation. Our data thus reveal a previously unrecognized function for the neuronal calcium sensor protein VILIP1 and a mechanism for regulation of ATP-dependent P2X receptor signaling by neuronal calcium sensors. PMID:18922787

  13. Robust optimization of 2x2 multimode interference couplers with fabrication uncertainties

    NASA Astrophysics Data System (ADS)

    Rehman, Samee ur; Langelaar, Matthijs; Van Keulen, Fred

    2013-03-01

    In this paper, we propose a novel design-for-manufacture strategy for integrated photonics which specifically addresses the commonly encountered scenario in which probability distributions of the manufacturing variations are not available, however their bounds are known. The best design point for the device, in the presence of these uncertainties, can be found by applying robust optimization. This is performed by minimizing the maximum realizable value of the objective with respect to the uncertainty set so that an optimum is found whose performance is relatively immune to fabrication variations. Instead of applying robust optimization directly on a computationally expensive simulation model of the integrated photonic device, we construct a cheap surrogate model by uniformly sampling the simulated device at different values of the design variables and interpolating the resulting objective using a Kriging metamodel. By applying robust optimization on the constructed surrogate, the global robust optimum can be found at low computational cost. As an illustration of the method's general applicability, we apply the robust optimization approach on a 2x2 multimode interference (MMI) coupler. We robustly minimize the imbalance in the presence of uncertainties arising from variations in the fabricated design geometry. For this example device, we also study the influence of the number of sample points on the quality of the metamodel and on the robust optimization process.

  14. DESIGN AND LAYOUT CONCEPTS FOR COMPACT, FACTORY-PRODUCED, TRANSPORTABLE, GENERATION IV REACTOR SYSTEMS

    SciTech Connect

    Mynatt Fred R.; Townsend, L.W.; Williamson, Martin; Williams, Wesley; Miller, Laurence W.; Khan, M. Khurram; McConn, Joe; Kadak, Andrew C.; Berte, Marc V.; Sawhney, Rapinder; Fife, Jacob; Sedler, Todd L.; Conway, Larry E.; Felde, Dave K.

    2003-11-12

    The purpose of this research project is to develop compact (100 to 400 MWe) Generation IV nuclear power plant design and layout concepts that maximize the benefits of factory-based fabrication and optimal packaging, transportation and siting. The reactor concepts selected were compact designs under development in the 2000 to 2001 period. This interdisciplinary project was comprised of three university-led nuclear engineering teams identified by reactor coolant type (water, gas, and liquid metal) and a fourth Industrial Engineering team. The reactors included a Modular Pebble Bed helium-cooled concept being developed at MIT, the IRIS water-cooled concept being developed by a team led by Westinghouse Electric Company, and a Lead-Bismuth-cooled concept developed by UT. In addition to the design and layout concepts this report includes a section on heat exchanger manufacturing simulations and a section on construction and cost impacts of proposed modular designs.

  15. Regulation of GABAA Receptor Dynamics by Interaction with Purinergic P2X2 Receptors*

    PubMed Central

    Shrivastava, Amulya Nidhi; Triller, Antoine; Sieghart, Werner; Sarto-Jackson, Isabella

    2011-01-01

    γ-Aminobutyric acid type A receptors (GABAARs) in the spinal cord are evolving as an important target for drug development against pain. Purinergic P2X2 receptors (P2X2Rs) are also expressed in spinal cord neurons and are known to cross-talk with GABAARs. Here, we investigated a possible “dynamic” interaction between GABAARs and P2X2Rs using co-immunoprecipitation and fluorescence resonance energy transfer (FRET) studies in human embryonic kidney (HEK) 293 cells along with co-localization and single particle tracking studies in spinal cord neurons. Our results suggest that a significant proportion of P2X2Rs forms a transient complex with GABAARs inside the cell, thus stabilizing these receptors and using them for co-trafficking to the cell surface, where P2X2Rs and GABAARs are primarily located extra-synaptically. Furthermore, agonist-induced activation of P2X2Rs results in a Ca2+-dependent as well as an apparently Ca2+-independent increase in the mobility and an enhanced degradation of GABAARs, whereas P2X2Rs are stabilized and form larger clusters. Antagonist-induced blocking of P2XRs results in co-stabilization of this receptor complex at the cell surface. These results suggest a novel mechanism where association of P2X2Rs and GABAARs could be used for specific targeting to neuronal membranes, thus providing an extrasynaptic receptor reserve that could regulate the excitability of neurons. We further conclude that blocking the excitatory activity of excessively released ATP under diseased state by P2XR antagonists could simultaneously enhance synaptic inhibition mediated by GABAARs. PMID:21343285

  16. The Walking Interventions Through Texting (WalkIT) Trial: Rationale, Design, and Protocol for a Factorial Randomized Controlled Trial of Adaptive Interventions for Overweight and Obese, Inactive Adults

    PubMed Central

    Hurley, Jane C; Hollingshead, Kevin E; Todd, Michael; Jarrett, Catherine L; Tucker, Wesley J; Angadi, Siddhartha S

    2015-01-01

    Background Walking is a widely accepted and frequently targeted health promotion approach to increase physical activity (PA). Interventions to increase PA have produced only small improvements. Stronger and more potent behavioral intervention components are needed to increase time spent in PA, improve cardiometabolic risk markers, and optimize health. Objective Our aim is to present the rationale and methods from the WalkIT Trial, a 4-month factorial randomized controlled trial (RCT) in inactive, overweight/obese adults. The main purpose of the study was to evaluate whether intensive adaptive components result in greater improvements to adults’ PA compared to the static intervention components. Methods Participants enrolled in a 2x2 factorial RCT and were assigned to one of four semi-automated, text message–based walking interventions. Experimental components included adaptive versus static steps/day goals, and immediate versus delayed reinforcement. Principles of percentile shaping and behavioral economics were used to operationalize experimental components. A Fitbit Zip measured the main outcome: participants’ daily physical activity (steps and cadence) over the 4-month duration of the study. Secondary outcomes included self-reported PA, psychosocial outcomes, aerobic fitness, and cardiorespiratory risk factors assessed pre/post in a laboratory setting. Participants were recruited through email listservs and websites affiliated with the university campus, community businesses and local government, social groups, and social media advertising. Results This study has completed data collection as of December 2014, but data cleaning and preliminary analyses are still in progress. We expect to complete analysis of the main outcomes in late 2015 to early 2016. Conclusions The Walking Interventions through Texting (WalkIT) Trial will further the understanding of theory-based intervention components to increase the PA of men and women who are healthy, insufficiently

  17. Formulation and optimization of temozolomide nanoparticles by 3 factor 2 level factorial design

    PubMed Central

    Jain, Aviral; Jain, Sanjay K.

    2013-01-01

    The aim of this study was to investigate the combined influence of 3 independent variables in the preparation of temozolomide bearing Non-PEGylated and PEGylated nanoparticles by emulsification solvent evaporation method. A 3 factor 2 level design was used to derive a polynomial quadratic model and construct contour plots to predict responses. The independent variables selected were concentration of drug (A), concentration of PLGA/PEG-PLGA (B), PVA concentration in aqueous phase (C) and sonication time (D) and evaluated for percentage drug entrapment (PDE) and particle size (PS). A 34 factorial design was used with 4 factors (A, B, C and D) at 3 levels and experimental trials were performed at all 82 possible combinations. In the present work, 28 runs are considered as the preliminary trials revealed that on increasing drug concentration from 2.5 to 5 mg the percent drug entrapment increases, but on further increasing the drug concentration (i.e., to 7.5 mg) no significant effect on the percent drug entrapment and particle size was observed. The 34 factorial design was used to derive a polynomial quadratic model and construct contour plots to predict responses. Contour plots were constructed to show the effects of A, B, C and D on the PDE and PS. PMID:23719178

  18. Factorial design analysis for COD removal from landfill leachate by photoassisted Fered-Fenton process.

    PubMed

    Wu, Xiaogang; Zhang, Hui; Li, Yanli; Zhang, Daobin; Li, Xianwang

    2014-01-01

    The Fered-Fenton process has been shown to be an effective method for leachate treatment, but it still faces problems of inadequate regeneration of ferrous ion. However, the use of the photoassisted Fered-Fenton process could overcome this difficulty and improve the efficiency of chemical oxygen demand (COD) removal since photoassisted Fered-Fenton process induces the production of hydroxyl radicals from the regeneration of ferrous ions and the reaction of hydrogen peroxide with UV light. As there are so many operating parameters in photoassisted Fered-Fenton process, it is necessary to develop a mathematical model in order to produce the most economical process. In the present study, a factorial design was carried out to evaluate leachate treatment by photoassisted Fered-Fenton process. The influence of the following variables: H₂O₂ concentration, Fe(2+) concentration, current density, and initial pH in the photoassisted Fered-Fenton process was investigated by measuring COD removal efficiencies after 60-min reaction. The relationship between COD removal and the most significant independent variables was established by means of an experimental design. The H₂O₂ concentration, Fe(2+) concentration, initial pH, and the interaction effect between current density and initial pH were all significant factors. The factorial design models were derived based on the COD removal efficiency results and the models fit the data well.

  19. Formulation of Topical Bioadhesive Gel of Aceclofenac Using 3-Level Factorial Design

    PubMed Central

    Singh, Sanjay; Parhi, Rabinarayan; Garg, Anuj

    2011-01-01

    The objective of this work was to develop bioadhesive topical gel of Aceclofenac with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 = X1) and hydroxypropylmethyl cellulose K100 M (HPMC = X2)] on the bioadhesive character of gel, rheological property of gel (consistency index), and in-vitro drug release. The best model was selected to fit the data. Mathematical equation was generated by Design Expert® software for the model which assists in determining the effect of independent variables. Response surface plots were also generated by the software for analyzing effect of the independent variables on the response. Quadratic model was found to be the best for all the responses. Both independent variable (X1 and X2) were found to have synergistic effect on bioadhesion (Y1) but the effect of HPMC was more pronounced than PL-407. Consistency index was enhanced by increasing the level of both independent variables. An antagonistic effect of both independent variables was found on cumulative percentage release of drug in 2 (Y3) and 8 h (Y4). Both independent variables approximately equally contributed the antagonistic effect on Y3 whereas antagonistic effect of HPMC was more pronounced than PL-407. The effect of formulation variables on the product characteristics can be easily predicted and precisely interpreted by using a 3-level factorial experimental design and generated quadratic mathematical equations. PMID:24250375

  20. Neutrino factories

    SciTech Connect

    Soler, F. J. P.

    2015-07-15

    The Neutrino Factory is a facility that produces neutrino beams with a well-defined flavour content and energy spectrum from the decay of intense, high-energy, stored muon beams to establish CP violation in the neutrino sector. The International Design Study for the Neutrino Factory (the IDS-NF) is providing a Reference Design Report (RDR) for the facility. The present design is optimised for the recent measurements of θ{sub 13}. The accelerator facility will deliver 10{sup 21} muon decays per year from 10 GeV stored muon beams. The straight sections of the storage ring point to a 100 kton Magnetised Iron Neutrino Detector (MIND) at a distance of 2000-2500 km from the source. The accuracy in the value of δ{sub CP} that a Neutrino Factory can achieve and the δ{sub CP} coverage is unrivalled by other future facilities. Staging scenarios for the Neutrino Factory deliver facilities that can carry out physics at each stage. In the context of Fermilab, such a scenario would imply in the first stage the construction of a small storage ring, nuSTORM, to carry out neutrino cross-section and sterile neutrino measurements and to perform a programme of 6D muon cooling R&D. The second stage is the construction of a 5 GeV Neutrino Factory (nuMAX) pointing to the Sanford Underground Research Facility at Homestake and the final stage would use many of the components of this facility to construct a Muon Collider, initially as a 126 GeV CM Higgs Factory, which may be upgraded to a multi-TeV Muon Collider if required.

  1. A multicenter two by two factorial trial of cognitive behavioral therapy and aerobic exercise for Gulf War veterans' illnesses: design of a veterans affairs cooperative study (CSP #470).

    PubMed

    Guarino, P; Peduzzi, P; Donta, S T; Engel, C C; Clauw, D J; Williams, D A; Skinner, J S; Barkhuizen, A; Kazis, L E; Feussner, J R

    2001-06-01

    The Department of Veterans Affairs (VA) Cooperative Studies Program (CSP) Study #470 is a 2 x 2 factorial trial designed to evaluate the hypothesis that both cognitive behavioral therapy (CBT) and aerobic exercise will significantly improve physical function in participants with Gulf War veterans' illnesses (GWVI), and that adding CBT to aerobic exercise will provide further incremental benefit. One thousand three hundred fifty-six veterans will be randomized to one of four treatment arms: CBT plus aerobic exercise plus usual and customary care, aerobic exercise plus usual and customary care, CBT plus usual and customary care, or usual and customary care alone. The study duration is 2.5 years with 1.5 years of intake and 1 year of follow-up. The primary outcome measure is the proportion of veterans improved more than seven units on the physical component summary (PCS) scale of the Short Form Health Survey for Veterans (SF-36V) measured 12 months after randomization. This generic quality-of-life measure was chosen because there is no disease-specific measure for GWVI and the symptoms of GWVI span a wide range of physical manifestations that are related to the domains covered by the PCS scale. Sample size was determined to detect all six pairwise comparisons between the four treatment arms with 90% power and a Bonferroni adjustment for an overall type I error of 0.05 or 0.05/6 = 0.0083. CSP #470 was initiated in May 1999 in 18 VA and two Department of Defense medical centers. To date this represents the largest randomized trial designed to evaluate treatments for individuals with unexplained physical symptoms. This paper will focus on the rationale and unique features of the study design. Control Clin Trials 2001;22:310-332

  2. Neutrino Factories

    SciTech Connect

    Geer, Steve; /Fermilab

    2010-01-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture and accelerate O(10{sup 21}) muons/year. This prepares the way for a Neutrino Factory (NF) in which high energy muons decay within the straight sections of a storage ring to produce a beam of neutrinos and anti-neutrinos. The NF concept was proposed in 1997 at a time when the discovery that the three known types of neutrino ({nu}{sub e}, {nu}{sub {mu}}, {nu}{sub {tau}}) can change their flavor as they propagate through space (neutrino oscillations) was providing a first glimpse of physics beyond the Standard Model. This development prepares the way for a new type of neutrino source: a Neutrino Factory. This article reviews the motivation, design and R&D for a Neutrino Factory.

  3. Factorial design studies of antiretroviral drug-loaded stealth liposomal injectable: PEGylation, lyophilization and pharmacokinetic studies

    NASA Astrophysics Data System (ADS)

    Sudhakar, Beeravelli; Krishna, Mylangam Chaitanya; Murthy, Kolapalli Venkata Ramana

    2016-01-01

    The aim of the present study was to formulate and evaluate the ritonavir-loaded stealth liposomes by using 32 factorial design and intended to delivered by parenteral delivery. Liposomes were prepared by ethanol injection method using 32 factorial designs and characterized for various physicochemical parameters such as drug content, size, zeta potential, entrapment efficiency and in vitro drug release. The optimization process was carried out using desirability and overlay plots. The selected formulation was subjected to PEGylation using 10 % PEG-10000 solution. Stealth liposomes were characterized for the above-mentioned parameters along with surface morphology, Fourier transform infrared spectrophotometer, differential scanning calorimeter, stability and in vivo pharmacokinetic studies in rats. Stealth liposomes showed better result compared to conventional liposomes due to effect of PEG-10000. The in vivo studies revealed that stealth liposomes showed better residence time compared to conventional liposomes and pure drug solution. The conventional liposomes and pure drug showed dose-dependent pharmacokinetics, whereas stealth liposomes showed long circulation half-life compared to conventional liposomes and pure ritonavir solution. The results of statistical analysis showed significance difference as the p value is (<0.05) by one-way ANOVA. The result of the present study revealed that stealth liposomes are promising tool in antiretroviral therapy.

  4. An approach to formulating an oral floating drug delivery system for dexchlorpheniramine maleate using factorial design.

    PubMed

    Alabazi, M Y; Elzein, H

    2012-07-01

    The purpose of this research was to formulate and evaluate a floating tablet formulation of dexchlorpheniramine maleate (DCPM) using full factorial design. A 32 factorial design (nine runs) was utilized to optimize the formulation, the contents of hydroxypropyl methyl cellulose (HPMC) (X1) and Carbopol 934P (X2) being taken as independent variables and t50% (Y1), % drug release after 6 h (Y2), % drug release after 12 h (Y3), and floating lag time (FLT) (Y4) as the dependent variables. The tablets showed 99.2635 to 102.4709 of the labeled amount of dexchlorpheniramine maleate indicating uniformity of content. The tablets containing DCPM released 72.28 to 99.461% of drug at the end of 12 h by an in vitro release study. Hardness, friability, floating capacity, weight variation and content uniformity were also examined. In addition,the tablets were evaluated for in vitro release characteristics for 24 h. The optimal batch (F9) was selected by regression analysis and followed Higuchi kinetics. The drug release mechanism was found to be a complex mixture of diffusion, swelling and erosion. The floating tablets of DCPM developed may be used clinically for prolonged drug release for at least 16 hrs, thereby improving bioavailability and patient compliance.

  5. Amphotericin B-loaded polymeric nanoparticles: formulation optimization by factorial design.

    PubMed

    Carraro, Talita Cristina Moreira Moraes; Khalil, Najeh Maissar; Mainardes, Rubiana Mara

    2016-03-01

    In this study, PLGA or PLGA-PEG blend nanoparticles were developed loading amphotericin B (AmB), an antifungal agent broadly used in therapy. A 2(2) × 3(1) factorial experimental design was conducted to indicate an optimal formulation of nanoparticles containing AmB and demonstrate the influence of the interactions of components on the mean particle size and drug encapsulation efficiency. The independent variables analyzed were polymer amount (two levels) and organic phase (three factors in one level). The parameters methanol as cosolvent and higher polymer amount originated from the higher AmB encapsulation, but with the larger particle size. The selected optimized parameters were set as the lower polymer amount and ethyl acetate as cosolvent in organic phase, for both PLGA and PLGA-PEG nanoparticles. These parameters originated from nanoparticles with the size of 189.5 ± 90 nm and 169 ± 6.9 nm and AmB encapsulation efficiency of 94.0 ± 1.3% and 92.8 ± 2.9% for PLGA and PLGA-PEG nanoparticles, respectively. Additionally, these formulations showed a narrow size distribution indicating homogeneity in the particle size. PLGA and PLGA-PEG nanoparticles are potential carrier for AmB delivery and the factorial design presented an important tool in optimizing nanoparticles formulations.

  6. Neutrino factory

    DOE PAGES

    Bogomilov, M.; Matev, R.; Tsenov, R.; Dracos, M.; Bonesini, M.; Palladino, V.; Tortora, L.; Mori, Y.; Planche, T.; Lagrange, J. B.; et al

    2014-12-08

    The properties of the neutrino provide a unique window on physics beyond that described by the standard model. The study of subleading effects in neutrino oscillations, and the race to discover CP-invariance violation in the lepton sector, has begun with the recent discovery that theta(13) > 0. The measured value of theta(13) is large, emphasizing the need for a facility at which the systematic uncertainties can be reduced to the percent level. The neutrino factory, in which intense neutrino beams are produced from the decay of muons, has been shown to outperform all realistic alternatives and to be capable ofmore » making measurements of the requisite precision. Its unique discovery potential arises from the fact that only at the neutrino factory is it practical to produce high-energy electron (anti) neutrino beams of the required intensity. This paper presents the conceptual design of the neutrino factory accelerator facility developed by the European Commission Framework Programme 7 EURO nu. Design Study consortium. EURO nu coordinated the European contributions to the International Design Study for the Neutrino Factory (the IDS-NF) collaboration. The EURO nu baseline accelerator facility will provide 10(21) muon decays per year from 12.6 GeV stored muon beams serving a single neutrino detector situated at a source-detector distance of between 1 500 km and 2 500 km. A suite of near detectors will allow definitive neutrino-scattering experiments to be performed.« less

  7. Neutrino factory

    SciTech Connect

    Bogomilov, M.; Matev, R.; Tsenov, R.; Dracos, M.; Bonesini, M.; Palladino, V.; Tortora, L.; Mori, Y.; Planche, T.; Lagrange, J. B.; Kuno, Y.; Benedetto, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoini, S.; Martini, M.; Wildner, E.; Prior, G.; Blondel, A.; Karadzhow, Y.; Ellis, M.; Kyberd, P.; Bayes, R.; Laing, A.; Soler, F. J. P.; Alekou, A.; Apollonio, M.; Aslaninejad, M.; Bontoiu, C.; Jenner, L. J.; Kurup, A.; Long, K.; Pasternak, J.; Zarrebini, A.; Poslimski, J.; Blackmore, V.; Cobb, J.; Tunnell, C.; Andreopoulos, C.; Bennett, J. R.J.; Brooks, S.; Caretta, O.; Davenne, T.; Densham, C.; Edgecock, T. R.; Fitton, M.; Kelliher, D.; Loveridge, P.; McFarland, A.; Machida, S.; Prior, C.; Rees, G.; Rogers, C.; Rooney, M.; Thomason, J.; Wilcox, D.; Booth, C.; Skoro, G.; Back, J. J.; Harrison, P.; Berg, J. S.; Fernow, R.; Gallardo, J. C.; Gupta, R.; Kirk, H.; Simos, N.; Stratakis, D.; Souchlas, N.; Witte, H.; Bross, A.; Geer, S.; Johnstone, C.; Makhov, N.; Neuffer, D.; Popovic, M.; Strait, J.; Striganov, S.; Morfín, J. G.; Wands, R.; Snopok, P.; Bagacz, S. A.; Morozov, V.; Roblin, Y.; Cline, D.; Ding, X.; Bromberg, C.; Hart, T.; Abrams, R. J.; Ankenbrandt, C. M.; Beard, K. B.; Cummings, M. A.C.; Flanagan, G.; Johnson, R. P.; Roberts, T. J.; Yoshikawa, C. Y.; Graves, V. B.; McDonald, K. T.; Coney, L.; Hanson, G.

    2014-12-08

    The properties of the neutrino provide a unique window on physics beyond that described by the standard model. The study of subleading effects in neutrino oscillations, and the race to discover CP-invariance violation in the lepton sector, has begun with the recent discovery that theta(13) > 0. The measured value of theta(13) is large, emphasizing the need for a facility at which the systematic uncertainties can be reduced to the percent level. The neutrino factory, in which intense neutrino beams are produced from the decay of muons, has been shown to outperform all realistic alternatives and to be capable of making measurements of the requisite precision. Its unique discovery potential arises from the fact that only at the neutrino factory is it practical to produce high-energy electron (anti) neutrino beams of the required intensity. This paper presents the conceptual design of the neutrino factory accelerator facility developed by the European Commission Framework Programme 7 EURO nu. Design Study consortium. EURO nu coordinated the European contributions to the International Design Study for the Neutrino Factory (the IDS-NF) collaboration. The EURO nu baseline accelerator facility will provide 10(21) muon decays per year from 12.6 GeV stored muon beams serving a single neutrino detector situated at a source-detector distance of between 1 500 km and 2 500 km. A suite of near detectors will allow definitive neutrino-scattering experiments to be performed.

  8. Neutrino factory

    NASA Astrophysics Data System (ADS)

    Bogomilov, M.; Matev, R.; Tsenov, R.; Dracos, M.; Bonesini, M.; Palladino, V.; Tortora, L.; Mori, Y.; Planche, T.; Lagrange, J. B.; Kuno, Y.; Benedetto, E.; Efthymiopoulos, I.; Garoby, R.; Gilardoini, S.; Martini, M.; Wildner, E.; Prior, G.; Blondel, A.; Karadzhow, Y.; Ellis, M.; Kyberd, P.; Bayes, R.; Laing, A.; Soler, F. J. P.; Alekou, A.; Apollonio, M.; Aslaninejad, M.; Bontoiu, C.; Jenner, L. J.; Kurup, A.; Long, K.; Pasternak, J.; Zarrebini, A.; Poslimski, J.; Blackmore, V.; Cobb, J.; Tunnell, C.; Andreopoulos, C.; Bennett, J. R. J.; Brooks, S.; Caretta, O.; Davenne, T.; Densham, C.; Edgecock, T. R.; Fitton, M.; Kelliher, D.; Loveridge, P.; McFarland, A.; Machida, S.; Prior, C.; Rees, G.; Rogers, C.; Rooney, M.; Thomason, J.; Wilcox, D.; Booth, C.; Skoro, G.; Back, J. J.; Harrison, P.; Berg, J. S.; Fernow, R.; Gallardo, J. C.; Gupta, R.; Kirk, H.; Simos, N.; Stratakis, D.; Souchlas, N.; Witte, H.; Bross, A.; Geer, S.; Johnstone, C.; Makhov, N.; Neuffer, D.; Popovic, M.; Strait, J.; Striganov, S.; Morfín, J. G.; Wands, R.; Snopok, P.; Bagacz, S. A.; Morozov, V.; Roblin, Y.; Cline, D.; Ding, X.; Bromberg, C.; Hart, T.; Abrams, R. J.; Ankenbrandt, C. M.; Beard, K. B.; Cummings, M. A. C.; Flanagan, G.; Johnson, R. P.; Roberts, T. J.; Yoshikawa, C. Y.; Graves, V. B.; McDonald, K. T.; Coney, L.; Hanson, G.

    2014-12-01

    The properties of the neutrino provide a unique window on physics beyond that described by the standard model. The study of subleading effects in neutrino oscillations, and the race to discover CP-invariance violation in the lepton sector, has begun with the recent discovery that θ13>0 . The measured value of θ13 is large, emphasizing the need for a facility at which the systematic uncertainties can be reduced to the percent level. The neutrino factory, in which intense neutrino beams are produced from the decay of muons, has been shown to outperform all realistic alternatives and to be capable of making measurements of the requisite precision. Its unique discovery potential arises from the fact that only at the neutrino factory is it practical to produce high-energy electron (anti)neutrino beams of the required intensity. This paper presents the conceptual design of the neutrino factory accelerator facility developed by the European Commission Framework Programme 7 EURO ν Design Study consortium. EURO ν coordinated the European contributions to the International Design Study for the Neutrino Factory (the IDS-NF) collaboration. The EURO ν baseline accelerator facility will provide 1 021 muon decays per year from 12.6 GeV stored muon beams serving a single neutrino detector situated at a source-detector distance of between 1 500 km and 2 500 km. A suite of near detectors will allow definitive neutrino-scattering experiments to be performed.

  9. Lattice design for the high energy ring of the SLAC B-Factory (PEP-II)

    SciTech Connect

    Donald, M.H.R.; Cai, Y.; Irwin, J.

    1995-04-01

    The design of the lattice for the High Energy Ring (HER) of the SLAC B-Factory has several special features, notably provision for octupole compensation of amplitude dependent tune shift effects and a beta-beat scheme for semi-local chromaticity correction. In the arcs adjacent to the interaction point (IP) the beta functions are enhanced to allow the use of non-interlaced sextupoles to compensate the chromaticity of the interaction region. A closed bump of beta {open_quotes}mismatch{close_quotes} is generated by two vertically focusing quadrupoles spaced 2 betatron wavelengths apart. The beta-beat has two advantages: it enhances the ratio between the horizontal and vertical beta functions at the sextupoles and, because of the locally higher beta function, allows weaker sextupoles to be used. The standard design uses a 60 degree/cell lattice but a 90 degree/cell lattice may also be used if lower emittances and momentum compaction factor are desired.

  10. The HARP Hadron Production Experiment and Its Significance for Neutrino Factory Design

    NASA Astrophysics Data System (ADS)

    Howlett, L. C.

    2004-03-01

    A neutrino factory would provide a high flux beam of electron and muon neutrinos with well understood energy and flavour composition for detailed studies of neutrino oscillations. Such a beam requires a large number of muons and hence pions, which would be provided by a proton driver and pion production target. The optimal design of such a pion production target and the necessary pion capture system need accurate knowledge of hadron production at energies of several GeV. HARP, a large acceptance particle spectrometer of conventional design, aims to measure hadron production cross sections on thin and thick nuclear targets in the range of beam momentum 2-15 GeV/c in order to provide the desired data.

  11. Design and Factory Test of the E /E- Frascati Linear Accelerator for DAFNE

    SciTech Connect

    Anamkath, H.; Lyons, S.; Nett, D.; Treas, P.; Whitham, K.; Zante, T.; Miller, R.; Boni, R.; Hsieh, H.; Sannibale, F.; Vescovi, M.; Vignola, G.; /Frascati

    2011-11-28

    The electron-positron accelerator for the DAFNE project has been built and is in test at Titan Beta in Dublin, CA. This S-Band RF linac system utilizes four 45 MW sledded klystrons and 16-3 m accelerating structures to achieve the required performance. It delivers a 4 ampere electron beam to the positron converter and accelerates the resulting positrons to 550 MeV. The converter design uses a 4.3T pulsed tapered flux compressor along with a pseudo-adiabatic tapered field to a 5 KG solenoid over the first two positron accelerating sections. Quadrupole focusing is used after 100 MeV. The system performance is given in Table 1. This paper briefly describes the design and development of the various subassemblies in this system and gives the initial factory test data.

  12. Virtual patients design and its effect on clinical reasoning and student experience: a protocol for a randomised factorial multi-centre study

    PubMed Central

    2012-01-01

    Background Virtual Patients (VPs) are web-based representations of realistic clinical cases. They are proposed as being an optimal method for teaching clinical reasoning skills. International standards exist which define precisely what constitutes a VP. There are multiple design possibilities for VPs, however there is little formal evidence to support individual design features. The purpose of this trial is to explore the effect of two different potentially important design features on clinical reasoning skills and the student experience. These are the branching case pathways (present or absent) and structured clinical reasoning feedback (present or absent). Methods/Design This is a multi-centre randomised 2x2 factorial design study evaluating two independent variables of VP design, branching (present or absent), and structured clinical reasoning feedback (present or absent).The study will be carried out in medical student volunteers in one year group from three university medical schools in the United Kingdom, Warwick, Keele and Birmingham. There are four core musculoskeletal topics. Each case can be designed in four different ways, equating to 16 VPs required for the research. Students will be randomised to four groups, completing the four VP topics in the same order, but with each group exposed to a different VP design sequentially. All students will be exposed to the four designs. Primary outcomes are performance for each case design in a standardized fifteen item clinical reasoning assessment, integrated into each VP, which is identical for each topic. Additionally a 15-item self-reported evaluation is completed for each VP, based on a widely used EViP tool. Student patterns of use of the VPs will be recorded. In one centre, formative clinical and examination performance will be recorded, along with a self reported pre and post-intervention reasoning score, the DTI. Our power calculations indicate a sample size of 112 is required for both primary outcomes

  13. Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study

    PubMed Central

    Chattopadhyay, Helen; De, Amit Kumar; Datta, Sriparna

    2015-01-01

    The aim of our present work was to optimize the ratio of a very novel polymer, starch-polyvinyl alcohol (PVA), for controlled delivery of Ornidazole. Polymer-coated drug microparticles were prepared by emulsion method. Microscopic study, scanning electron microscopic study, and atomic force microscopic study revealed that the microparticles were within 10 micrometers of size with smooth spherical shape. The Fourier transform infrared spectroscopy showed absence of drug polymer interaction. A statistical 32 full factorial design was used to study the effect of different concentration of starch and PVA on the drug release profile. The three-dimensional plots gave us an idea about the contribution of each factor on the release kinetics. Hence this novel polymer of starch and polyvinyl alcohol can be utilized for control release of the drug from a targeted delivery device. PMID:27347511

  14. The Role of Synthetic Biology in the Design of Microbial Cell Factories for Biofuel Production

    PubMed Central

    Colin, Verónica Leticia; Rodríguez, Analía; Cristóbal, Héctor Antonio

    2011-01-01

    Insecurity in the supply of fossil fuels, volatile fuel prices, and major concerns regarding climate change have sparked renewed interest in the production of fuels from renewable resources. Because of this, the use of biodiesel has grown dramatically during the last few years and is expected to increase even further in the future. Biodiesel production through the use of microbial systems has marked a turning point in the field of biofuels since it is emerging as an attractive alternative to conventional technology. Recent progress in synthetic biology has accelerated the ability to analyze, construct, and/or redesign microbial metabolic pathways with unprecedented precision, in order to permit biofuel production that is amenable to industrial applications. The review presented here focuses specifically on the role of synthetic biology in the design of microbial cell factories for efficient production of biodiesel. PMID:22028591

  15. Factorial design, physicochemical characterisation and activity of ciprofloxacin-PLGA nanoparticles.

    PubMed

    Dillen, Kathleen; Vandervoort, Jo; Van den Mooter, Guy; Verheyden, Loes; Ludwig, Annick

    2004-05-01

    Poly(lactide-co-glycolide) nanoparticles incorporating ciprofloxacin HCl were prepared by means of a W/O/W emulsification solvent evaporation method. The stabiliser selected was poly(vinylalcohol). A 2(4) full factorial design based on four independent variables was used to plan the experiments and the variable parameters were the number of homogenisation cycles, addition of boric acid to the inner water phase containing the drug, ciprofloxacin concentration in the inner water phase and oil:outer water phase ratio. The effects of these parameters on the particle size, zeta potential, drug loading efficiency and drug release were investigated. Also the effect of gamma irradiation on the particle size and drug release was evaluated and DSC and XRD analyses of the compounds and the nanoparticles were performed. The activity on two series of microorganisms, Pseudomonas aeruginosa and Staphylococcus aureus, was examined. PMID:15081148

  16. Advanced Envelope Research for Factory Built Housing, Phase 3. Design Development and Prototyping

    SciTech Connect

    Levy, E.; Kessler, B.; Mullens, M.; Rath, P.

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  17. Advanced Envelope Research for Factory Built Housing, Phase 3 -- Design Development and Prototyping

    SciTech Connect

    Levy, E.; Kessler, B.; Mullens, M.; Rath, P.

    2014-01-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective alternative envelope designs. In the near term, these technologies will play a central role in meeting stringent energy code requirements. For manufactured homes, the thermal requirements, last updated by statute in 1994, will move up to the more rigorous IECC 2012 levels in 2013, the requirements of which are consistent with site built and modular housing. This places added urgency on identifying envelope technologies that the industry can implement in the short timeframe. The primary goal of this research is to develop wall designs that meet the thermal requirements based on 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing the new envelope technologies. This work is part of a four-phase, multi-year effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three selected methods for building high performance wall systems. Phase 2 focused on the development of viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped critique and select the most viable solution to move further in the research -- stud walls with continuous exterior insulation. Phase 3, the subject of the current report, focused on the design development of the selected wall concept and explored variations on the use of exterior foam insulation. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing.

  18. The 2 x 2 Model of Perfectionism: A Comparison across Asian Canadians and European Canadians

    ERIC Educational Resources Information Center

    Franche, Veronique; Gaudreau, Patrick; Miranda, Dave

    2012-01-01

    The 2 x 2 model of perfectionism posits that the 4 within-person combinations of self-oriented and socially prescribed perfectionism (i.e., pure SOP, mixed perfectionism, pure SPP, and nonperfectionism) can be distinctively associated with psychological adjustment. This study examined whether the relationship between the 4 subtypes of…

  19. Visualization of the trimeric P2X2 receptor with a crown-capped extracellular domain.

    PubMed

    Mio, Kazuhiro; Kubo, Yoshihiro; Ogura, Toshihiko; Yamamoto, Tomomi; Sato, Chikara

    2005-11-25

    The P2X2 purinergic receptor permeates cationic ions in response to stimulation by ATP and mediates fast synaptic transmission. Here, we purified the P2X2 receptor using baculovirus-Sf9 cell expression system and observed its structure using electron microscopy. The FLAG-tagged P2X2 receptor, which has intact ion channel function, was purified to be a single peak by affinity purification and gel filtration chromatography. It was confirmed to be a trimer by introducing cross-linking. Negatively stained P2X2 protein images were homogeneous and picked up by automated pick-up programs, aligned, and classified using the modified growing neural gas network method. Similarly oriented projections were averaged to decrease the signal-to-noise ratio. These images demonstrate an inverted three-sided pyramid with the dimensions of 215 A in height and 200 A in side length. It is composed of a high-density trunk and a stain-permeable swollen extracellular domain of a crown-shaped structure. The internal cavities and constituent segments were clearly demonstrated in both the raw images and the averaged images. The threefold symmetrical top view demonstrates the first visual evidence of the trimeric composition of the P2X receptor family. PMID:16219297

  20. Gender Differences in the Factor Structure of the 2x2 Achievement Goal Framework

    ERIC Educational Resources Information Center

    Alkharusi, Hussain; Aldhafri, Said

    2010-01-01

    The present study examined gender differences in the factor structure of the 2x2 achievement goal framework using a multi-sample invariance analysis. A total of 117 male and 125 female undergraduate teacher education students completed Elliot and Murayama's (2008) Achievement Goal Questionnaire-Revised (AGQ-R). Results provided empirical evidence…

  1. Extending the 2 x 2 Achievement Goal Framework: Development of a Measure of Scientific Achievement Goals

    ERIC Educational Resources Information Center

    Deemer, Eric D.; Carter, Alice P.; Lobrano, Michael T.

    2010-01-01

    The current research sought to extend the 2 x 2 achievement goal framework by developing and testing the Achievement Goals for Research Scale (AGRS). Participants (N = 317) consisted of graduate students in the life, physical, and behavioral sciences. A principal components analysis (PCA) extracted five components accounting for 72.59% of the…

  2. Window types: (from left to right) Pair of 2x2 multipaned ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Window types: (from left to right) Pair of 2x2 multipaned steel casements; triplet of 1x4 multipaned steel casements (center panel fixed); 1x3 multipaned steel casements. Building 20, facing southwest - Harbor Hills Housing Project, 26607 Western Avenue, Lomita, Los Angeles County, CA

  3. Procrastination and the 2 x 2 Achievement Goal Framework in Malaysian Undergraduate Students

    ERIC Educational Resources Information Center

    Ganesan, Rajalakshmi; Mamat, Norul Hidayah Bt; Mellor, David; Rizzuto, Laura; Kolar, Christina

    2014-01-01

    The present study investigated academic procrastination in the context of the 2 x 2 goal achievement theoretical framework within a population of 450 Malaysian undergraduate students, aged 18 to 25 years. Participants completed the Achievement Goal Questionnaire and the Tuckman Procrastination Test. Approach dimensions of both the mastery and…

  4. Cohen's Linearly Weighted Kappa Is a Weighted Average of 2 x 2 Kappas

    ERIC Educational Resources Information Center

    Warrens, Matthijs J.

    2011-01-01

    An agreement table with [n as an element of N is greater than or equal to] 3 ordered categories can be collapsed into n - 1 distinct 2 x 2 tables by combining adjacent categories. Vanbelle and Albert ("Stat. Methodol." 6:157-163, 2009c) showed that the components of Cohen's weighted kappa with linear weights can be obtained from these n - 1…

  5. Optimization of protocell of silica nanoparticles using 3² factorial designs.

    PubMed

    Kaur, Gunjeet; Rath, Goutam; Heer, Hemraj; Goyal, Amit K

    2012-03-01

    The purpose of the research is to carry out systemic optimization of protocells (liposomes entrapped with silica particles). Optimization was carried out using 3(2) factorial designs for the selection of the optimized protocell composition with reference to particle size distribution and zetapotential. This design was carried out to study the effect of independent variables such as molar ratio of phosphatidylcholine to cholesterol and concentration of silica nanoparticles. A total of nine formulations of protocells were prepared and analyzed using Design expert® software from Stat-Ease, Inc. (Version 8.0.4.1 trial 2010) for the selection of the optimized combination. Contour plots were constructed with independent variables like size and potential. Protocell with 7:3 ratio of phosphatidyl choline to cholesterol and 0.5 mg/ml of silica nanoparticles demonstrated better colloidal behaviors. The findings obtained from the software corresponding to independent variables demonstrated accurate means for the optimization of the pharmaceutical formulations. PMID:22173376

  6. Complete factorial design experiment for 3D load cell instrumented crank validation.

    PubMed

    Omar, Valle-Casas; Rafael, Dalazen; Vinicius, Cene; Alexandre, Balbinot

    2015-08-01

    Developing of instrumentation systems for sport medicine is a promising area, that's why this research evaluates the design of a new instrumented crank arm prototype for a race bicycle projecting an experiment for indoor - outdoor comparison. This study investigated the viability of an instrumentation 3D load cell for force measurement crank, implementing a design of experiment. A Complete factorial design experiment was developed for data validation, with an Analysis of Variance (ANOVA) throwing significant results for controlled factors with response variables rms, mean and variance. A software routine allowed to obtained system variables metrics for Symmetry and Cadence analysis, which came out from Effective force bilateral comparing and speed computation. Characterization allowed achieving calibration curves that were used for data conversion in force projection channels with a linearity error of 0.29% (perpendicular), 0.55% (parallel) and 0.10% (lateral). Interactions of factors resulted significant mainly for indoor tests in symmetry and cadence was significant in interactions generally for outdoor tests. Implemented system was able to generate Effective Force graph for 3D plot symmetry analysis, torque and power symmetry for specialist's analysis.

  7. Application of factorial designs for optimization of cyclodextrin glycosyltransferase production from Klebsiella pneumoniae pneumoniae AS-22.

    PubMed

    Gawande, B N; Patkar, A Y

    1999-07-20

    Production of cyclodextrin glycosyltransferase (CGTase) from Klebsiella pneumoniae pneumoniae AS-22 was optimized in shake flasks using a statistical experimental design approach. Effect of various components in the basal medium, like carbon, nitrogen, phosphorus, and mineral sources as well as initial pH and temperature, were tested on enzyme production. The optimum concentrations of the selected media components were determined using statistical experimental designs. Two level fractional factorial designs in five variables, namely, dextrin, peptone, yeast extract, ammonium dihydrogen orthophosphate, and magnesium sulphate concentrations were constructed. The optimum medium composition thus found consisted of 49.3 g/L dextrin, 20.6 g/L peptone, 18.3 g/L yeast extract, 6.7 g/L ammonium dihydrogen orthophosphate, and 0.5 g/L magnesium sulphate. The maximum CGTase activity obtained was 21.4 U/mL in 28 h of incubation. The cell growth and CGTase production profiles were studied with the optimized medium in shake flasks and in 1-L fermenters. It was observed that the enzyme production was growth associated both in shake flask and in fermenter, although it was slower in shake flask. The maximum CGTase activity obtained in the fermenter was 32.5 U/mL in 16 h. The optimized medium resulted in about 9-fold increase in the enzyme activity as compared to that obtained in the basal medium in shake flask as well as in fermenter. PMID:10397852

  8. Alternative Solutions for ANOVA Using 2-Way and 3-Way Completely Randomized Factorial Designs with Disproportional Cell Sizes.

    ERIC Educational Resources Information Center

    Pugh, Richard C.; And Others

    Three alternative solutions available for analysis of variance (ANOVA) using two-way and three-way completely randomized factorial designs with disproportional cell sizes across all two-way and three-way summary tables with no empty cells are discussed. These solutions are categorized as unique, sequential, and experimental. The procedures used,…

  9. Solid Lipid Nanoparticles of Atovaquone Based on 24 Full-Factorial Design

    PubMed Central

    Mohtar, Noratiqah; A. K. Khan, Nurzalina; Darwis, Yusrida

    2015-01-01

    Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shear homogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipid matrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimization of the formulations was conducted using 6 sets of 24 full-factorial design based on four independent variables that were the number of homogenizing cycles, concentration of the lipid, concentration of the co-surfactant, and concentration of the main surfactant. The dependent variables were particle size and polydispersity index (PdI). The homogenizing cycles showed a negative influence on the dependent variables which reduced both the particle size and the PdI value. Moreover, a combination of certain percentages of the main surfactant and co-surfactant also showed a negative influence that reduced both the particle size and PdI value. Selected formulations from each design were further characterized for the entrapment efficiency and yield. The optimised formulation of ATQ-SLN consisted of trilaurin, Phospholipon 90H and Tween 80 with a particle size of 89.4 ± 0.2 nm and entrapment efficiency of 83.0 ± 1.7%. The in-vitro release evaluation of the formulation showed a complete and immediate release of ATQ from the SLN that could be a solution to improve the poor aqueous solubility and hence poor bioavailability of the drug. PMID:26664366

  10. Assessment of the recycling potential of fresh concrete waste using a factorial design of experiments.

    PubMed

    Correia, S L; Souza, F L; Dienstmann, G; Segadães, A M

    2009-11-01

    Recycling of industrial wastes and by-products can help reduce the cost of waste treatment prior to disposal and eventually preserve natural resources and energy. To assess the recycling potential of a given waste, it is important to select a tool capable of giving clear indications either way, with the least time and work consumption, as is the case of modelling the system properties using the results obtained from statistical design of experiments. In this work, the aggregate reclaimed from the mud that results from washout and cleaning operations of fresh concrete mixer trucks (fresh concrete waste, FCW) was recycled into new concrete with various water/cement ratios, as replacement of natural fine aggregates. A 3(2) factorial design of experiments was used to model fresh concrete consistency index and hardened concrete water absorption and 7- and 28-day compressive strength, as functions of FCW content and water/cement ratio, and the resulting regression equations and contour plots were validated with confirmation experiments. The results showed that the fresh concrete workability worsened with the increase in FCW content but the water absorption (5-10 wt.%), 7-day compressive strength (26-36 MPa) and 28-day compressive strength (32-44 MPa) remained within the specified ranges, thus demonstrating that the aggregate reclaimed from FCW can be recycled into new concrete mixtures with lower natural aggregate content. PMID:19596189

  11. Full factorial design for optimization, development and validation of HPLC method to determine valsartan in nanoparticles.

    PubMed

    Kumar, Lalit; Sreenivasa Reddy, M; Managuli, Renuka S; Pai K, Girish

    2015-10-01

    High performance liquid chromatographic method was optimized, developed and validated as per the ICH guidelines. In this study the 20 mM ammonium formate and acetonitrile in the 57:43 ratio were used as mobile phase for the analysis of valsartan. Full factorial design was used to optimize the effect of variable factors. The responses were peak area, tailing factor and number of theoretical plates. The quadratic effect of flow rate and wavelength individually as well as in interaction were most significant (p < 0.0001 and p < 0.0086, respectively) on peak area; the quadratic effect of pH of buffer was also most significant effect (p < 0.0001) on tailing factor (5%) whereas the quadratic effect of flow rate and wavelength individually was significant (p = 0.0006 and p = 0.0265, respectively) on the number of theoretical plates. The high-performance liquid chromatographic separation was performed at the flow rate 1.0 min/mL, UV detector wavelength 250 nm and pH of the buffer 3.0 as optimized parameters using design of experiments. The retention time values of valsartan were found to be 10.177 min. Percent recovery in terms of accuracy for the prepared valsartan nanoparticles was found in the range of 98.57-100.27%. PMID:26594122

  12. Structures and magnetism of two types of c(2x2)-Mn/Pd(001) surface alloys

    SciTech Connect

    Tsuboi, N.; Okuyama, H.; Aruga, T.

    2005-05-15

    Mn/Pd(001) surface alloy was investigated by a tensor low-energy electron diffraction (LEED) analysis. After deposition of Mn on Pd(001) at room temperature, the surface was annealed at 570-620 K, which produced two types of c(2x2) surface alloys, according to the Mn coverage. At a low-Mn coverage, we obtained a Pd-capped c(2x2) surface, in which the first layer was composed of a (1x1)-Pd layer, and the second layer was a c(2x2)-MnPd mixed layer [{alpha}-c(2x2)]. The deposition of greater amounts of Mn followed by annealing resulted in another c(2x2) surface, in which Mn atoms existed in the substitutional sites of the first and third layers [{beta}-c(2x2)]. The first layer consisted of a c(2x2)-MnPd mixed layer, the second layer was a (1x1)-Pd layer, and the third layer was another c(2x2)-MnPd mixed layer. The structure of the {beta}-c(2x2) surface qualitatively agreed with the one previously investigated by LEED. These two types of surface alloys, {alpha}-c(2x2) and {beta}-c(2x2), may be considered as being precursors to the formation of the bulk MnPd{sub 3} alloy. We also investigated the magnetic properties of the {alpha}-c(2x2) and {beta}-c(2x2) surfaces by using surface magneto-optic Kerr effect (MOKE) and self-consistent, total-energy calculations. The MOKE measurements for both surface alloys show no hysterisis loop, even at 10 K. The total-energy calculation shows that Mn atoms have a local-spin moment of 3.9-4.1 {mu}{sub B} and that they are antiferromagnetically ordered in the ground state.

  13. Application of factorial design in optimization of preconcentration procedure for copper determination in soft drink by flame atomic absorption spectrometry.

    PubMed

    Castro, Martha T P O; Baccan, Nivaldo

    2005-03-15

    In the present paper, a procedure for preconcentration and determination of copper in soft drink using flame atomic absorption spectrometry (FAAS) is proposed, which is based on solid-phase extraction of copper(II) ions as its ion pair of 1,10-phenanthroline complexes with the anionic surfactant sodium dodecil sulphate (SDS), by Amberlite XAD-2 resin. The optimization process was carried out using 2(4-1) factorial and 2(2) factorial with a center point designs. Four variables (XAD-2 mass, copper mass, sample flow rate and elution flow rate) were regarded as factors in the optimization. Student's t-test on the results of the 2(4-1) factorial design with eight runs for copper extraction, demonstrated that the factors XAD-2 mass and sample flow rate in the levels studied are statistically significant. The 2(2) factorial with a center point design was applied in order to determine the optimum conditions for extraction. The procedure proposed allowed the determination of copper with detection limits (3alpha/S) of 3.9mugl(-1). The precision, calculated as relative standard deviation (R.S.D.) was 1.8% for 20.0mugl(-1) of copper. The preconcentration factor was 100. The robustness of this procedure is demonstrated by the recovery achieved for determination of copper in the presence of several cations. This procedure was applied to the determination of copper in soft drink samples collected in Campinas, SP, Brazil. PMID:18969940

  14. Prediction of intrinsic motivation and sports performance using 2 x 2 achievement goal framework.

    PubMed

    Li, Chiung-Huang; Chi, Likang; Yeh, Suh-Ruu; Guo, Kwei-Bin; Ou, Cheng-Tsung; Kao, Chun-Chieh

    2011-04-01

    The purpose of this study was to examine the influence of 2 x 2 achievement goals on intrinsic motivation and performance in handball. Participants were 164 high school athletes. All completed the 2 x 2 Achievement Goals Questionnaire for Sport and the Intrinsic Motivation subscale of the Sport Motivation Scale; the coach for each team rated his athletes' overall sports performance. Using simultaneous-regression analyses, mastery-approach goals positively predicted both intrinsic motivation and performance in sports, whereas performance-avoidance goals negatively predicted sports performance. These results suggest that athletes who pursue task mastery and improvement of their competence perform well and enjoy their participation. In contrast, those who focus on avoiding normative incompetence perform poorly.

  15. [A simple biostatistical method for meta analysis of the data on 2 x 2 table].

    PubMed

    Liu, G; Wang, J; Kang, D; Hong, Q

    2000-06-01

    Meta-analysis is a method in common use for data analysis in evidence-based medicine. In this paper, based on the Mantel-Haenszel and Peto methods used for Meta-analysis of the data on 2 x 2 table, we put forward a simple calculating method for clinicians. It is useful for Meta-analysis and can be easily applied to analysis of the data from multi-studies in evidence-based medicine.

  16. Entanglement monogamy inequality in a 2 x 2 x 4 system

    SciTech Connect

    Ren Xijun; Jiang Wei

    2010-02-15

    In this report, we show explicitly that the tangles of an arbitrary pure state in a 2 x 2 x 4 system satisfy the monogamy relation. This relation is also generalized to mixed states. As the tangle is always larger than the square of the concurrence, our result implies that the monogamy relation holds for concurrence too. It also supports the idea that the tangle could qualify as an elementary bipartite entanglement measure.

  17. Water adsorption on O(2x2)/Ru(0001) from STM experiments andfirst-principles calculations

    SciTech Connect

    Cabrera-Sanfelix, P.; Sanchez-Portal, D.; Mugarza, A.; Shimizu,T.K.; Salmeron, M.; Arnau, A.

    2007-10-15

    We present a combined theoretical and experimental study of water adsorption on Ru(0001) pre-covered with 0.25 monolayers (ML) of oxygen forming a (2 x 2) structure. Several structures were analyzed by means of Density Functional Theory calculations for which STM simulations were performed and compared with experimental data. Up to 0.25 monolayers the molecules bind to the exposed Ru atoms of the 2 x 2 unit cell via the lone pair orbitals. The molecular plane is almost parallel to the surface with its H atoms pointing towards the chemisorbed O atoms of the 2 x 2 unit cell forming hydrogen bonds. The existence of these additional hydrogen bonds increases the adsorption energy of the water molecule to approximately 616 meV, which is {approx}220 meV more stable than on the clean Ru(0001) surface with a similar configuration. The binding energy shows only a weak dependence on water coverage, with a shallow minimum for a row structure at 0.125 ML. This is consistent with the STM experiments that show a tendency of the molecules to form linear rows at intermediate coverage. Our calculations also suggest the possible formation of water dimers near 0.25 ML.

  18. Sliding Wear Response of Beryl Reinforced Aluminum Composite - A Factorial Design Approach

    NASA Astrophysics Data System (ADS)

    Bharat, V.; Durga Prasad, B.; Prabhakar, M. Bhovi; Venkateswarlu, K.

    2016-02-01

    Al-Beryl MMCs were successfully fabricated using powder metallurgy route. Processing conditions such as beryl content and particle size were varied and its influence on dry sliding wear response was studied. Effect of test parameters like applied load and sliding distance on wear performance of Al-Beryl MMCs were discussed detail. Sliding wear tests were conducted using a pin on disc machine based on the 24 (4 factors at 2 levels) factorial design. Analysis of variance (ANOVA) was performed to obtain the contribution of control parameters on wear rate. The present study shows that wear resistance of Al-beryl MMCs not only depends on the beryl content but also influenced by normal load, sliding distance and particle size. The results show that most significant variables affecting wear rate of Al - beryl MMCs are size of the beryl particles (22%), beryl content (19.60%), sliding distance (18.47%), and normal load (10.30%). The interaction effects of these parameters are less significant in influencing wear rate compared to the individual parameters. The correlation between sliding wear and its parameters was obtained by multiple regression analysis. Regression model developed in the present study can be successfully implemented to predict the wear response of Al-Beryl MMCs.

  19. Compatible validated spectrofluorimetric and spectrophotometric methods for determination of vildagliptin and saxagliptin by factorial design experiments

    NASA Astrophysics Data System (ADS)

    Abdel-Aziz, Omar; Ayad, Miriam F.; Tadros, Mariam M.

    2015-04-01

    Simple, selective and reproducible spectrofluorimetric and spectrophotometric methods have been developed for the determination of vildagliptin and saxagliptin in bulk and their pharmaceutical dosage forms. The first proposed spectrofluorimetric method is based on the dansylation reaction of the amino group of vildagliptin with dansyl chloride to form a highly fluorescent product. The formed product was measured spectrofluorimetrically at 455 nm after excitation at 345 nm. Beer's law was obeyed in a concentration range of 100-600 μg ml-1. The second proposed spectrophotometric method is based on the charge transfer complex of saxagliptin with tetrachloro-1,4-benzoquinone (p-chloranil). The formed charge transfer complex was measured spectrophotometrically at 530 nm. Beer's law was obeyed in a concentration range of 100-850 μg ml-1. The third proposed spectrophotometric method is based on the condensation reaction of the primary amino group of saxagliptin with formaldehyde and acetyl acetone to form a yellow colored product known as Hantzsch reaction, measured at 342.5 nm. Beer's law was obeyed in a concentration range of 50-300 μg ml-1. All the variables were studied to optimize the reactions' conditions using factorial design. The developed methods were validated and proved to be specific and accurate for quality control of vildagliptin and saxagliptin in their pharmaceutical dosage forms.

  20. Compatible validated spectrofluorimetric and spectrophotometric methods for determination of vildagliptin and saxagliptin by factorial design experiments.

    PubMed

    Abdel-Aziz, Omar; Ayad, Miriam F; Tadros, Mariam M

    2015-04-01

    Simple, selective and reproducible spectrofluorimetric and spectrophotometric methods have been developed for the determination of vildagliptin and saxagliptin in bulk and their pharmaceutical dosage forms. The first proposed spectrofluorimetric method is based on the dansylation reaction of the amino group of vildagliptin with dansyl chloride to form a highly fluorescent product. The formed product was measured spectrofluorimetrically at 455 nm after excitation at 345 nm. Beer's law was obeyed in a concentration range of 100-600 μg ml(-1). The second proposed spectrophotometric method is based on the charge transfer complex of saxagliptin with tetrachloro-1,4-benzoquinone (p-chloranil). The formed charge transfer complex was measured spectrophotometrically at 530 nm. Beer's law was obeyed in a concentration range of 100-850 μg ml(-1). The third proposed spectrophotometric method is based on the condensation reaction of the primary amino group of saxagliptin with formaldehyde and acetyl acetone to form a yellow colored product known as Hantzsch reaction, measured at 342.5 nm. Beer's law was obeyed in a concentration range of 50-300 μg ml(-1). All the variables were studied to optimize the reactions' conditions using factorial design. The developed methods were validated and proved to be specific and accurate for quality control of vildagliptin and saxagliptin in their pharmaceutical dosage forms.

  1. Pediatric diabetic ketoacidosis, fluid therapy, and cerebral injury: the design of a factorial randomized controlled trial.

    PubMed

    Glaser, Nicole S; Ghetti, Simona; Casper, T Charles; Dean, J Michael; Kuppermann, Nathan

    2013-09-01

    Treatment protocols for pediatric diabetic ketoacidosis (DKA) vary considerably among centers in the USA and worldwide. The optimal protocol for intravenous (IV) fluid administration is an area of particular controversy, mainly in regard to possible associations between rates of IV fluid infusion and the development of cerebral edema (CE), the most common and the most feared complication of DKA in children. Theoretical concerns about associations between osmotic fluid shifts and CE have prompted recommendations for conservative fluid infusion during DKA. However, recent data suggest that cerebral hypoperfusion may play a role in cerebral injury associated with DKA. Currently, there are no existing data from prospective clinical trials to determine the optimal fluid treatment protocol for pediatric DKA. The Pediatric Emergency Care Applied Research Network FLUID (FLuid therapies Under Investigation in DKA) study is the first prospective randomized trial to evaluate fluid regimens for pediatric DKA. This 13-center nationwide factorial design study will evaluate the effects of rehydration rate and fluid sodium content on neurological status during DKA treatment, the frequency of clinically overt CE and long-term neurocognitive outcomes following DKA. PMID:23490311

  2. Exposure to movie smoking, antismoking ads and smoking intensity: an experimental study with a factorial design

    PubMed Central

    Harakeh, Zeena; Engels, Rutger C M E; Vohs, Kathleen; van Baaren, Rick B; Sargent, James

    2013-01-01

    Background This study examines whether smoking portrayal in movies or antismoking advertisements affect smoking intensity among young adults. Methods We conducted an experimental study in which 84 smokers were randomly assigned using a two (no-smoking versus smoking portrayal in the movie) by three (two prosocial ads, two antismoking ads or one of each) factorial design. Participants viewed a 60-minute movie with two commercial breaks and afterwards completed a questionnaire. Smoking during the session was allowed and observed. Results Exposure to the movie with smoking had no effect on smoking intensity. Those who viewed two antismoking ads had significantly lower smoking intensity compared with those who viewed two prosocial ads. There was no interaction between movie smoking and antismoking ads. Baseline CO (carbon monoxide) level had the largest effect on smoking intensity. Conclusion These findings provide further evidence to support antismoking ads placed with movies because of their possible effect on young adult smoking behaviour. However, caution is warranted, because nicotine dependence appears to be the primary predictor of smoking intensity among young adult smokers in this study. PMID:20008155

  3. Pediatric diabetic ketoacidosis, fluid therapy, and cerebral injury: the design of a factorial randomized controlled trial.

    PubMed

    Glaser, Nicole S; Ghetti, Simona; Casper, T Charles; Dean, J Michael; Kuppermann, Nathan

    2013-09-01

    Treatment protocols for pediatric diabetic ketoacidosis (DKA) vary considerably among centers in the USA and worldwide. The optimal protocol for intravenous (IV) fluid administration is an area of particular controversy, mainly in regard to possible associations between rates of IV fluid infusion and the development of cerebral edema (CE), the most common and the most feared complication of DKA in children. Theoretical concerns about associations between osmotic fluid shifts and CE have prompted recommendations for conservative fluid infusion during DKA. However, recent data suggest that cerebral hypoperfusion may play a role in cerebral injury associated with DKA. Currently, there are no existing data from prospective clinical trials to determine the optimal fluid treatment protocol for pediatric DKA. The Pediatric Emergency Care Applied Research Network FLUID (FLuid therapies Under Investigation in DKA) study is the first prospective randomized trial to evaluate fluid regimens for pediatric DKA. This 13-center nationwide factorial design study will evaluate the effects of rehydration rate and fluid sodium content on neurological status during DKA treatment, the frequency of clinically overt CE and long-term neurocognitive outcomes following DKA.

  4. Factorial design in the optimization of preconcentration procedure for lead determination by FAAS.

    PubMed

    Soylak, Mustafa; Narin, Ibrahim; Bezerra, Marcos de Almeida; Ferreira, Sérgio Luís Costa

    2005-02-28

    The present paper proposes a preconcentration procedure for lead determination using flame atomic absorption spectrometry (FAAS). It is based on lead(II) ions extraction as brilliant cresyl blue (BCB) complex and its sorption onto Diaion HP-2MG, a methacrylic ester copolymer. The optimization step was carried out using factorial design and the variables studied were pH, shaking time and reagent concentration. In the established experimental conditions, lead can be determinate with a limit of detection of 3.7mugL(-1) lead (N = 20) and a relative standard deviation of 7% for a lead concentration of 100mugL(-1). The accuracy was confirmed by analysis of a certified reference material, the stream sediment furnished by National Research Centre for Certified Reference Materials (NRCCRM), China (GBW 07310). Effect of other ions in the procedure proposed was also studied. The method was applied for lead determination in real samples of water, tea, soil and dust. Tests of addition/recovery in the experiments for lead determination in water samples revealed that the proposed procedure could be applied satisfactorily for analysis of these samples. PMID:18969885

  5. Development and optimization of novel controlled-release pioglitazone provesicular powders using 3² factorial design.

    PubMed

    Shukr, Marwa H; Eltablawy, Nadia A

    2015-02-01

    This work aimed at studying a novel controlled drug delivery proniosomal formulation of pioglitazone for treatment of diabetes type-2. The effects of independent variables like type of surfactant and ratio of surfactants/cholesterol were studied using 3(2) factorial design. The provesicular powders were characterized regarding their encapsulation efficiency, vesicle size, morphology, and in vitro drug release. The revealed optimal provesicular powder was exposed to stability testing and in vivo performance evaluation. Results showed that F6 was selected as the optimal formulation, and its in vivo hypoglycemic effect on normal healthy and STZ-induced diabetic albino rats was investigated. F6 proniosomal formulation exhibited a significantly higher % decrease (56.18 % for STZ-induced diabetic albino rats) of blood glucose level (BGL) than Actos® (32. % for STZ-induced diabetic albino rats). Higher % decrease of BGL with longer t max and lower AUC0-24 confirms the development of a successful proniosomal pioglitazone formulation. PMID:25787339

  6. Biosorption of Ni(II) by Fig Male: Optimization and Modeling Using a Full Factorial Design.

    PubMed

    Madjene, F; Chergui, A; Trari, M

    2016-06-01

    The fig male (FM) is successfully used as biosorbent for Ni(2+) removal. The maximum removal efficiency (96.6%) is obtained at pH ~ 5 for a concentration of 1.70 mmol L(-1) and catalyst dose of 5 g L(-1) in less than 10 minutes. The Ni(2+) uptake follows a pseudo-second-order kinetic, the rate constants increase with increasing temperature, and an activation energy of 55.48 kJ mol(-1) is found. The thermodynamic parameters indicate a spontaneous endothermic bisorption. The isotherm data are fitted by the Langmuir and Dubinin-Radushkevich models. The former indicates a maximum Ni(2+) uptake of 0.459 mmol g(-1), which is higher than that of most biosorbents investigated to date. The FTIR spectra reveal the biosorption mechanism between Ni(2+) and FM functional groups. An empirical modeling is performed by using a 2(3) full factorial design, and a regression equation for Ni(2+) biosorption is determined. The biosorbent mass and pH are the most significant parameters affecting the Ni(2+) biosorption. PMID:27225783

  7. Mucoadhesive Hydrogel Films of Econazole Nitrate: Formulation and Optimization Using Factorial Design

    PubMed Central

    Gajra, Balaram; Pandya, Saurabh S.; Singh, Sanjay; Rabari, Haribhai A.

    2014-01-01

    The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 32 full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles) and the concentration of the poly(vinyl alcohol) (10, 15, and 20%) were used as the independent variables whereas time required for 50% drug release, cumulative percent of drug release at 8th hour, and “k” of zero order equation were used as the dependent variables. The films were evaluated for mucoadhesive strength, in vitro residence time, swelling study, in vitro drug release, and effectiveness against Candida albicans. The concentration of poly(vinyl alcohol) and the number of freeze/thaw cycles both decrease the drug release rate. Mucoadhesive hydrogel film with 15% poly(vinyl alcohol) and 7 freeze/thaw cycles was optimized. The optimized batch exhibited the sustained release of drug and the antifungal studies revealed that the drug released from the film could inhibit the growth of Candida albicans for 12 hours. PMID:25006462

  8. Evaluating the treatment of obstructive sleep apnea comorbid with insomnia disorder using an incomplete factorial design.

    PubMed

    Crawford, Megan R; Turner, Arlener D; Wyatt, James K; Fogg, Louis F; Ong, Jason C

    2016-03-01

    Chronic insomnia disorder is a prevalent condition and a significant proportion of these individuals also have obstructive sleep apnea (OSA). These two sleep disorders have distinct pathophysiology and are managed with different treatment approaches. High comorbidity rates have been a catalyst for emerging studies examining multidisciplinary treatment for OSA comorbid with insomnia disorder. In this article, we describe a randomized clinical trial of cognitive behavioral treatment for insomnia (CBT-I) and positive airway pressure (PAP) for OSA. Participants are randomized to receive one of three treatment combinations. Individuals randomized to treatment Arm A receive sequential treatment beginning with CBT-I followed by PAP, in treatment Arm B CBT-I and PAP are administered concurrently. These treatment arms are compared to a control condition, treatment Arm C, where individuals receive PAP alone. Adopting an incomplete factorial study design will allow us to evaluate the efficacy of multidisciplinary treatment (Arms A & B) versus standard treatment alone (Arm C). In addition, the random allocation of individuals to the two different combined treatment sequences (Arm A and Arm B) will allow us to understand the benefits of the sequential administration of CBT-I and PAP relative to concurrent treatment of PAP and CBT-I. These findings will provide evidence of the clinical benefits of treating insomnia disorder in the context of OSA.

  9. Full factorial design optimization of anti-inflammatory drug release by PCL-PEG-PCL microspheres.

    PubMed

    Azouz, L'Hachemi; Dahmoune, Farid; Rezgui, Farouk; G'Sell, Christian

    2016-01-01

    A biodegradable triblock poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) copolymer was successfully synthesized by ring-opening polymerization of ε-caprolactone, and was characterized by intrinsic viscosimetry, (1)H nuclear magnetic resonance, infrared spectroscopy and X-ray diffraction. Copolymer microparticles loaded with ibuprofen were prepared by an oil-in-water (o/w) emulsion solvent evaporation process. They were carefully weighted and characterized through their zeta potential. In this work, 4 selected process parameters (shaking speed X1, time of contact X2, poly(vinyl alcohol) concentration X3, and ibuprofen concentration X4) were adjusted at 2 different values. For each of the 16 experimental conditions, repeated twice, the drug encapsulation efficiency of the microspheres was determined, according to the following definition: EE (X1, X2, X3, X4)=mass of encapsulated ibuprofen/total weight of ibuprofen. A "full factorial design method" was applied to analyze the results statistically according to a polynomial fit and to determine the optimal conditions for the microencapsulation of the ibuprofen through an accurate statistical protocol. The microparticles obtained exhibit a spherical shape as shown by electron microscopy.

  10. Design of a 10**36 CM-2 S-1 Super-B Factory

    SciTech Connect

    Biagini, M.E.; Boni, R.; Boscolo, M.; Demma, T.; Drago, A.; Guiducci, S.; Raimondi, P.; Tomassini, S.; Zobov, M.; Bertsche, Kirk J.; Novokhatski, A.; Seeman, J.; Sullivan, M.; Wienands, U.; Wittmer, W.; Bettoni, S.; Paoloni, E.; Marchiori, G.; Bogomyagkov, A.; Koop, I.; Levichev, E.; /Novosibirsk, IYF

    2011-10-24

    Parameters have been studied for a high luminosity e{sup +}e{sup -} collider operating at the Upsilon 4S that would deliver a luminosity of 1 to 4 x 10{sup 36}/cm{sup 2}/s. This collider, called a Super-B Factory, would use a combination of linear collider and storage ring techniques. In this scheme an electron beam and a positron beam are stored in low-emittance damping rings similar to those designed for a Linear Collider (LC) or the next generation light source. A LC style interaction region is included in the ring to produce sub-millimeter vertical beta functions at the collision point. A large crossing angle (+/- 24 mrad) is used at the collision point to allow beam separation. A crab-waist scheme is used to reduce the hourglass effect and restore peak luminosity. Beam currents of 1.8 A at 4 x 7 GeV in 1251 bunches can produce a luminosity of 10{sup 36}/cm{sup 2}/s with upgrade possibilities. Such a collider would produce an integrated luminosity of about 10,000 fb{sup -1} (10 ab{sup -1}) in a running year (10{sup 7} sec) at the {gamma}(4S) resonance. Further possibilities include having longitudinally polarized e- at the IR and operating at the J/Psi and Psi beam energies.

  11. Overcoming obstacles in the implementation of factorial design for assay optimization.

    PubMed

    Shaw, Robert; Fitzek, Martina; Mouchet, Elizabeth; Walker, Graeme; Jarvis, Philip

    2015-03-01

    Factorial experimental design (FED) is a powerful approach for efficient optimization of robust in vitro assays-it enables cost and time savings while also improving the quality of assays. Although it is a well-known technique, there can be considerable barriers to overcome to fully exploit it within an industrial or academic organization. The article describes a tactical roll out of FED to a scientist group through: training which demystifies the technical components and concentrates on principles and examples; a user-friendly Excel-based tool for deconvoluting plate data; output which focuses on graphical display of data over complex statistics. The use of FED historically has generally been in conjunction with automated technology; however we have demonstrated a much broader impact of FED on the assay development process. The standardized approaches we have rolled out have helped to integrate FED as a fundamental part of assay development best practice because it can be used independently of the automation and vendor-supplied software. The techniques are applicable to different types of assay, both enzyme and cell, and can be used flexibly in manual and automated processes. This article describes the application of FED for a cellular assay. The challenges of selling FED concepts and rolling out to a wide bioscience community together with recommendations for good working practices and effective implementation are discussed. The accessible nature of these approaches means FED can be used by industrial as well as academic users.

  12. [Optimatization of pellet preparation is CF-granulator with factorial design].

    PubMed

    Beretzky, Adám; Antal, István; Karsai, János; Eros, István; Hódi, Klára

    2008-01-01

    Lithium carbonate-containing pellets were made in a laboratory-scale centrifugal granulator in order to investigate the effects of the process parameters (rotor rotation speed, slit airflow rate and spray air rate) on the pellet shape and size distribution. The size distribution and the shape parameters (roundness, roughness, rectangularity and sphericity) of the pellets were measured, and an optimization parameter was then calculated from these shape parameters. The experiment was carried out and evaluated according to a 2(3) full factorial design. All three variables were found to exert a significant effect on the pellet shape. With use of the signs and magnitudes of the coefficients of the variables in the fitted linear model, the direction of the gradient was determined; two control measurements were made. These proved the accuracy of the applied model and the direction of the gradient. Overall, a high rotor rotation speed and low slit airflow rate and spray air rate furnished the best value of the optimization parameter.

  13. Full factorial design, physicochemical characterisation and biological assessment of cyclosporine A loaded cationic nanoparticles.

    PubMed

    Hermans, Kris; Van den Plas, Dave; Everaert, Arnout; Weyenberg, Wim; Ludwig, Annick

    2012-09-01

    Cyclosporine A loaded poly(lactide-co-glycolide) nanoparticles coated with chitosan were prepared using the o/w emulsification solvent evaporation method. A 2(3) full factorial design was used to investigate the effect of 3 preparation parameters on the particle size, polydispersity index, zeta potential and drug release. In vitro experiments were performed in order to evaluate the cytotoxicity and anti-inflammatory activity of the developed nanoparticles. Particle sizes varied from 156 nm to 314 nm, and polydispersity index values of 0.07-0.56 were obtained depending on the different preparation parameters. All nanoparticles showed positive zeta potential values. Nanoparticles prepared with the highest concentration chitosan retained a positive zeta potential after dispersion in simulated lachrymal fluid, which supports the possibility of an electrostatic interaction between these particles and the negatively charged mucus layer at the eye. The in vitro release profile of cyclosporine A from the chitosan-coated nanoparticles was strongly dependent on the release medium used. None of the cationic nanoparticle formulations showed significant cytotoxicity compared to the negative control using human epithelial cells (HaCaT). Cyclosporine A encapsulated in the various nanoparticle formulations remained anti-inflammatory active as significant suppression of interleukine-2 secretion in concanavalin A stimulated Jurkat T cells was observed.

  14. Factorial design applied to the optimization of lipid composition of topical antiherpetic nanoemulsions containing isoflavone genistein

    PubMed Central

    Argenta, Débora Fretes; de Mattos, Cristiane Bastos; Misturini, Fabíola Dallarosa; Koester, Leticia Scherer; Bassani, Valquiria Linck; Simões, Cláudia Maria Oliveira; Teixeira, Helder Ferreira

    2014-01-01

    The aim of this study was to optimize topical nanoemulsions containing genistein, by means of a 23 full factorial design based on physicochemical properties and skin retention. The experimental arrangement was constructed using oil type (isopropyl myristate or castor oil), phospholipid type (distearoylphosphatidylcholine [DSPC] or dioleylphosphaditylcholine [DOPC]), and ionic cosurfactant type (oleic acid or oleylamine) as independent variables. The analysis of variance showed effect of third order for particle size, polydispersity index, and skin retention of genistein. Nanoemulsions composed of isopropyl myristate/DOPC/oleylamine showed the smallest diameter and highest genistein amount in porcine ear skin whereas the formulation composed of isopropyl myristate/DSPC/oleylamine exhibited the lowest polydispersity index. Thus, these two formulations were selected for further studies. The formulations presented positive ζ potential values (>25 mV) and genistein content close to 100% (at 1 mg/mL). The incorporation of genistein in nanoemulsions significantly increased the retention of this isoflavone in epidermis and dermis, especially when the formulation composed by isopropyl myristate/DOPC/oleylamine was used. These results were supported by confocal images. Such formulations exhibited antiherpetic activity in vitro against herpes simplex virus 1 (strain KOS) and herpes simplex virus 22 (strain 333). Taken together, the results show that the genistein-loaded nanoemulsions developed in this study are promising options in herpes treatment. PMID:25336951

  15. fullfact: an R package for the analysis of genetic and maternal variance components from full factorial mating designs.

    PubMed

    Houde, Aimee Lee S; Pitcher, Trevor E

    2016-03-01

    Full factorial breeding designs are useful for quantifying the amount of additive genetic, nonadditive genetic, and maternal variance that explain phenotypic traits. Such variance estimates are important for examining evolutionary potential. Traditionally, full factorial mating designs have been analyzed using a two-way analysis of variance, which may produce negative variance values and is not suited for unbalanced designs. Mixed-effects models do not produce negative variance values and are suited for unbalanced designs. However, extracting the variance components, calculating significance values, and estimating confidence intervals and/or power values for the components are not straightforward using traditional analytic methods. We introduce fullfact - an R package that addresses these issues and facilitates the analysis of full factorial mating designs with mixed-effects models. Here, we summarize the functions of the fullfact package. The observed data functions extract the variance explained by random and fixed effects and provide their significance. We then calculate the additive genetic, nonadditive genetic, and maternal variance components explaining the phenotype. In particular, we integrate nonnormal error structures for estimating these components for nonnormal data types. The resampled data functions are used to produce bootstrap-t confidence intervals, which can then be plotted using a simple function. We explore the fullfact package through a worked example. This package will facilitate the analyses of full factorial mating designs in R, especially for the analysis of binary, proportion, and/or count data types and for the ability to incorporate additional random and fixed effects and power analyses.

  16. Degradation characteristics of metoprolol during UV/chlorination reaction and a factorial design optimization.

    PubMed

    Nam, Seung-Woo; Yoon, Yeomin; Choi, Dae-Jin; Zoh, Kyung-Duk

    2015-03-21

    Metoprolol (MTP), a hypertension depressor, has been increasingly detected even after conventional water treatment processes. In this study, the removal of MTP was compared using chlorination (Cl2), UV-C photolysis, and UV/chlorination (Cl2/UV) reactions. The results showed that the UV/chlorination reaction was most effective for MTP removal. MTP removal during UV/chlorination reaction was optimized under various conditions of UV intensity (1.1-4.4 mW/cm(2)), chlorine dose (1-5 mg/L as Cl2), pH (2-9), and dissolved organic matter (DOM, 1-4 mgC/L) using a two-level factorial design with 16 experimental combinations of the four factors. Among the factors examined, DOM scavenging by OH radicals was the most dominant in terms of MTP removal during UV/chlorination reaction. The established model fit well with the experimental results using to various water samples including surface waters, filtered and tap water samples. The optimized conditions (UV intensity=4.4 mW/cm(2), [Cl2]=5 mg/L, pH 7, and [DOM]=0.8-1.1 mgC/L) of the model removed more than 78.9% of MTP for filtered water samples during UV/chlorination reaction. Using LC-MS/MS, five byproducts of MTP (molecular weight: 171, 211, 309, 313, and 341, respectively) were identified during UV/chlorination reaction. Based on this information, the MTP transformation mechanism during UV/chlorination was suggested. Our results imply that applying UV/chlorination process after filtration stage in the water treatment plant (WTP) would be the most appropriate for effective removal of MTP.

  17. Exploring factors affecting measurements of the static coefficient of friction: An application of fractional factorial experiment design

    NASA Astrophysics Data System (ADS)

    Folkerts, Timothy J.

    2004-10-01

    The common undergraduate experiment for determining the static coefficient of friction between a wooden block and a horizontal tabletop often produces inconsistent results. We show how several factors influence the measured magnitude and consistency of the coefficient of friction. We utilize a fractional factorial experimental design, which is a method that has been specifically developed to effectively and efficiently uncover key factors that most strongly influence experimental results.

  18. Operating manual holographic interferometry system for 2 x 2 foot transonic wind tunnel

    NASA Technical Reports Server (NTRS)

    Craig, J. E.

    1981-01-01

    A holographic interferometer system was installed in a 2X2 foot transonic wind tunnel. The system incorporates a modern, 10 pps, Nd:YAG pulsed laser which provides reliable operation and is easy to align. The spatial filtering requirements of the unstable resonator beam are described as well as the integration of the system into the existing Schieren system. A two plate holographic interferometer is used to reconstruct flow field data. For static wind tunnel models the single exposure holograms are recorded in the usual manner; however, for dynamic models such as oscillating airfoils, synchronous laser hologram recording is used.

  19. Examining Dual Meanings of Items in 2 x 2 Achievement Goal Questionnaires through MTMM Modeling and MDS Approach

    ERIC Educational Resources Information Center

    Wu, Chia-Huei; Chen, Lung Hung

    2010-01-01

    In 2001, Elliot and McGregor proposed a 2 x 2 (mastery-performance x approach- avoidance) achievement goal frameworks and developed a questionnaire to measure four goals (mastery-approach, mastery-avoidance, performance-approach, and performance-avoidance goals). This study examines the dual meanings of items in 2 x 2 achievement goal…

  20. NAMER: A FORTRAN 4 program for use in optimizing designs of two-level factorial experiments given partial prior information

    NASA Technical Reports Server (NTRS)

    Sidik, S. M.

    1972-01-01

    Under certain specified conditions, the Bayes procedure for designing two-level fractional factorial experiments is that which maximizes the expected utility over all possible choices of parameter-estimator matchings, physical-design variable matchings, defining parameter groups, and sequences of telescoping groups. NAMER computes the utility of all possible matchings of physical variables to design variables and parameters to estimators for a specified choice of defining parameter group or groups. The matching yielding the maximum expected utility is indicated, and detailed information is provided about the optimal matchings and utilities. Complete documentation is given; and an example illustrates input, output, and usage.

  1. Midlands Teaching Factory, LTD.

    ERIC Educational Resources Information Center

    Midlands Technical Coll., Columbia, SC.

    In 1987, Midlands Technical College (MTC), in Columbia, South Carolina, initiated a Computer Integrated Manufacturing (CIM) project, the Midlands Teaching Factory, LTD, which integrated various college departments with the goal of manufacturing a high quality, saleable product. The faculty developed a teaching factory model which was designed to…

  2. Development and characterization of floating microballoons for oral delivery of cinnarizine by a factorial design.

    PubMed

    Varshosaz, J; Tabbakhian, M; Zahrooni, M

    2007-05-01

    Cinnarizine (CN) is a pipperazine derivative with anti-histaminic activity and high affinity to H(1) receptors. The objective of this study was to produce floating microspheres (FM) of CN by diffusion solvent evaporation technique to increase drug solubility and hence its bioavailability. The effect of process variables such as: Eudragit type, stirring rate and time of stirring after addition of oily phase to the aqueous phase were evaluated on the yield, particle size, loading, release and floating behaviors of microspheres using a factorial design. Release of CN from microspheres was studied in pHs: 1.2 and 7.2 using paddle technique. The samples of dissolution test were analysed spectrophotometrically at 256.1 nm and 256.5 nm respectively. particle size of microspheres was studied using microscopic method and their floating behavior was studied in HCl (0.1 N, pH 1.2) medium with Tween 20 (0.5% w/v). Eight formulations were produced by changing 3 variables each at 2 levels: Eudragit S100 (Ps) or a combination of two Eudragits S100:RLPO (1:3) (P(SR)), stirring rate of 200 (R(2)) or 300 rpm (R(3)) and stirring time after addition of oily phase to the aqueous phase 0 (T(0)) or 1 hr (T(1)). The average size of microspheres was 300 microm. The highest yield efficiency (94%) was seen in P(SR)R(3)T(0) formulation and the greatest loading percentage was 8.5% in P(SR)R(2)T(1) formulation. The microspheres containing just Eudragit S100, didn't show suitable releasing profile during 8 hours in pH 1.2 but those containing combination of Eudragit S100:RL released approximately whole amount of CN during 10 hours (8 hours in pH 1.2 and 2 hours in pH 7.2). The highest floating percentage up to 6 hours was 77.5% in P(S)R(2)T(1) formulation. The type of Eudragit used seems to play an important role in producing sustained release floating microspheres. P(SR)R(3)T(0) formulation containing both types of Eudragit S100:RL (1.3) that releases 99.1% of the drug after 10 hours and 65

  3. Role of Dual Task Design When Measuring Cognitive Load during Multimedia Learning

    ERIC Educational Resources Information Center

    Schoor, Cornelia; Bannert, Maria; Brunken, Roland

    2012-01-01

    This study assessed the role different kinds of secondary tasks play for researching the modality effect of cognitive load theory. Ninety-six university students worked with a computer-based training program for approximately 13 min and had to fulfill an additional secondary task. In a 2 x 2 factorial design, modality of information presentation…

  4. e+ e- Factory Developments

    SciTech Connect

    Sullivan, Michael; /SLAC

    2010-08-26

    The impressive performance of current (KEKB) and recent (PEP-II) B-Factory colliders has increased interest in developing even higher luminosity B-factories. Two new designs are being developed (SuperKEKB and SuperB). Both designs plan to deliver a luminosity in the range of 1 x 10{sup 36} cm{sup -2}s{sup -1}, nearly 100 times the present B-factory level. Achieving this high luminosity requires high-current beams and short bunch lengths and/or a new way of colliding the beams. The SuperB design employs a crabbed magnetic waist with a large crossing angle and the SuperKEKB design is looking at crab cavities with high-current beams and/or a travelling focus. I describe the designs being studied to achieve the high luminosity needed for the next generation of B-Factories.

  5. A Non-scaling Fixed Field Alternating Gradient Accelerator for the Final Acceleration Stage of the International Design Study of the Neutrino Factory.

    SciTech Connect

    Berg, J.S.; Aslaninejad, M.; Pasternak, J.; Witte, H.; Bliss, N. Cordwell M.; Jones, T.; Muir, A., Kelliher, D.; Machida, S.

    2011-09-04

    The International Design Study of the Neutrino Factory (IDS-NF) has recently completed its Interim Design Report (IDR), which presents our current baseline design of the neutrino factory. To increase the efficiency and reduce the cost of acceleration, the IDR design uses a linear non-scaling fixed field alternating gradient accelerator (FFAG) for its final acceleration stage. We present the current lattice design of that FFAG, including the main ring plus its injection and extraction systems. We describe parameters for the main ring magnets, kickers, and septa, as well as the power supplies for the kickers. We present a first pass at an engineering layout for the ring and its subsystems.

  6. Activation of trimeric P2X2 receptors by fewer than three ATP molecules.

    PubMed

    Stelmashenko, Olga; Lalo, Ulyana; Yang, Yue; Bragg, Laricia; North, R Alan; Compan, Vincent

    2012-10-01

    P2X receptors are trimeric membrane proteins. When they bind extracellular ATP, a conformational change occurs that opens a transmembrane ion channel. The ATP-binding pocket is formed in a cleft between two subunits, and a critical amino acid residue for ATP contact is Lys⁶⁹ (P2X2 numbering). In the present work, we sought to determine whether the binding of fewer than three ATP molecules could open the ion channel. We expressed eight concatenated cDNAs in human embryonic kidney cells, which encoded three serially joined, epitope-tagged, subunits with either Lys or Ala at position 69 (denoted as KKK, KKA, KAK, AKK, KAA, AKA, AAK, and AAA). Western blotting of surface-biotinylated proteins indicated that breakdown of concatemers to individual subunits was minimal. Recording of membrane currents in response to ATP (whole cell and excised outside-out patch) showed that all formed functional channels except AAK, AKA, and AAA. There was no difference in the kinetics of activation and deactivation among KKK, KKA, KAK, and AKK channels, and amplitude of the unitary conductances was in all cases not different from that found after expression of a single wild-type subunit. Currents through KKA and KAK receptors were larger than those observed for AKK receptors. The results indicate that trimeric P2X receptors containing only two intact binding sites can be readily activated by ATP.

  7. Elucidating the Foundations of Statistical Inference with 2 x 2 Tables

    PubMed Central

    Choi, Leena; Blume, Jeffrey D.; Dupont, William D.

    2015-01-01

    To many, the foundations of statistical inference are cryptic and irrelevant to routine statistical practice. The analysis of 2 x 2 contingency tables, omnipresent in the scientific literature, is a case in point. Fisher's exact test is routinely used even though it has been fraught with controversy for over 70 years. The problem, not widely acknowledged, is that several different p-values can be associated with a single table, making scientific inference inconsistent. The root cause of this controversy lies in the table's origins and the manner in which nuisance parameters are eliminated. However, fundamental statistical principles (e.g., sufficiency, ancillarity, conditionality, and likelihood) can shed light on the controversy and guide our approach in using this test. In this paper, we use these fundamental principles to show how much information is lost when the tables origins are ignored and when various approaches are used to eliminate unknown nuisance parameters. We present novel likelihood contours to aid in the visualization of information loss and show that the information loss is often virtually non-existent. We find that problems arising from the discreteness of the sample space are exacerbated by p-value-based inference. Accordingly, methods that are less sensitive to this discreteness - likelihood ratios, posterior probabilities and mid-p-values - lead to more consistent inferences. PMID:25849515

  8. Evaluation of biomass production, carotenoid level and antioxidant capacity produced by Thermus filiformis Using fractional factorial design

    PubMed Central

    Mandelli, Fernanda; Yamashita, Fábio; Pereira, José L.; Mercadante, Adriana Z.

    2012-01-01

    A fractional factorial design 25–1 was used to evaluate the effect of temperature, pH, and concentrations of yeast extract, tryptone and Nitsch’s trace elements on the biomass, total carotenoids and protection against singlet oxygen by carotenoid extracts of the bacterium Thermus filiformis. In addition, the carotenoid composition was determined by high-performance liquid chromatography connected to a diode array and mass spectrometer detectors (HPLC-DAD-MS/MS). The production of biomass ranged from 0.113 to 0.658 g/L, the total carotenoid from 137.6 to 1,517.4 µg/g and the protection against singlet oxygen from 4.3 to 85.1 %. Results of the fractional factorial design showed that temperature had a negative effect on biomass production and a positive effect on carotenoid content and protection against singlet oxygen, besides, high levels of pH value, concentrations of yeast extract and tryptone had a positive effect on biomass production only at lower temperatures. The main carotenoids of T. filiformis were thermozeaxanthins. In the tested conditions, changes in the levels of the variables influenced the biomass, carotenoid production, and protection against singlet oxygen, although they did not influence the carotenoid profile. The results of this study provide a better understanding on the interactions among certain nutritional and cultivation conditions of a thermophile bacterium, Thermus filiformis, on biomass and carotenoid amounts, as well as on the antioxidant capacity. PMID:24031811

  9. Development of cationic solid lipid nanoparticles with factorial design-based studies for topical administration of doxorubicin.

    PubMed

    Taveira, Stephânia F; Araújo, Luciana M P de Campos; de Santana, Danielle C A S; Nomizo, Auro; de Freitas, Luiz Alexandre P; Lopez, Renata F V

    2012-04-01

    Topical chemotherapy using doxorubicin, a powerful anticancer drug, can be used as an alternative with reduced systemic toxicity when treating skin cancer. The aim of the present work was to use factorial design-based studies to develop cationic solid lipid nanoparticles containing doxorubicin; further investigations into the influence of these particles on the drug's cytotoxicity and cellular uptake in B16F10 murine melanoma cells were performed. A 32 full factorial design was applied for two different lipid phases; one phase used stearic acid and the other used a 1:2 mixture of stearic acid and glyceryl behenate. The two factors investigated included the ratio between the lipid and the water phase and the ratio between the surfactant (poloxamer) and the co-surfactant (cetylpyridinium chloride). It was observed that the studied factors did not affect the mean diameter or the polydispersity of the obtained nanoparticles; however, they did significantly affect the zeta potential values. Optimised formulations with particle sizes ranging from 251 to 306 nm and positive zeta potentials were selected for doxorubicin incorporation. High entrapment efficiencies were achieved (97%) in formulations with higher amounts of stearic acid, suggesting that cationic charges on doxorubicin molecules may interact with the negative charges in stearic acid. Melanoma culture cell experiments showed that cationic solid lipid nanoparticles without drug were not cytotoxic to melanoma cells. The encapsulation of doxorubicin significantly increased cytotoxicity, indicating the potential of these nanoparticles for the treatment of skin cancer.

  10. Optimization of thiamethoxam adsorption parameters using multi-walled carbon nanotubes by means of fractional factorial design.

    PubMed

    Panić, Sanja; Rakić, Dušan; Guzsvány, Valéria; Kiss, Erne; Boskovic, Goran; Kónya, Zoltán; Kukovecz, Ákos

    2015-12-01

    The aim of this work was to evaluate significant factors affecting the thiamethoxam adsorption efficiency using oxidized multi-walled carbon nanotubes (MWCNTs) as adsorbents. Five factors (initial solution concentration of thiamethoxam in water, temperature, solution pH, MWCNTs weight and contact time) were investigated using 2V(5-1) fractional factorial design. The obtained linear model was statistically tested using analysis of variance (ANOVA) and the analysis of residuals was used to investigate the model validity. It was observed that the factors and their second-order interactions affecting the thiamethoxam removal can be divided into three groups: very important, moderately important and insignificant ones. The initial solution concentration was found to be the most influencing parameter on thiamethoxam adsorption from water. Optimization of the factors levels was carried out by minimizing those parameters which are usually critical in real life: the temperature (energy), contact time (money) and weight of MWCNTs (potential health hazard), in order to maximize the adsorbed amount of the pollutant. The results of maximal adsorbed thiamethoxam amount in both real and optimized experiments indicate that among minimized parameters the adsorption time is one that makes the largest difference. The results of this study indicate that fractional factorial design is very useful tool for screening the higher number of parameters and reducing the number of adsorption experiments.

  11. An approach to optimize sample preparation for MALDI imaging MS of FFPE sections using fractional factorial design of experiments.

    PubMed

    Oetjen, Janina; Lachmund, Delf; Palmer, Andrew; Alexandrov, Theodore; Becker, Michael; Boskamp, Tobias; Maass, Peter

    2016-09-01

    A standardized workflow for matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI imaging MS) is a prerequisite for the routine use of this promising technology in clinical applications. We present an approach to develop standard operating procedures for MALDI imaging MS sample preparation of formalin-fixed and paraffin-embedded (FFPE) tissue sections based on a novel quantitative measure of dataset quality. To cover many parts of the complex workflow and simultaneously test several parameters, experiments were planned according to a fractional factorial design of experiments (DoE). The effect of ten different experiment parameters was investigated in two distinct DoE sets, each consisting of eight experiments. FFPE rat brain sections were used as standard material because of low biological variance. The mean peak intensity and a recently proposed spatial complexity measure were calculated for a list of 26 predefined peptides obtained by in silico digestion of five different proteins and served as quality criteria. A five-way analysis of variance (ANOVA) was applied on the final scores to retrieve a ranking of experiment parameters with increasing impact on data variance. Graphical abstract MALDI imaging experiments were planned according to fractional factorial design of experiments for the parameters under study. Selected peptide images were evaluated by the chosen quality metric (structure and intensity for a given peak list), and the calculated values were used as an input for the ANOVA. The parameters with the highest impact on the quality were deduced and SOPs recommended. PMID:27485623

  12. P2X2 and P2X5 Receptors Mediate Bladder Hyperesthesia in ICC in Female Overactive Bladder.

    PubMed

    Meng, Mingsen; Zheng, Ji; Yan, Junan; Li, Qianwei; Fang, Qiang; Li, Weibing

    2015-06-01

    This study was set to explore the role of P2X2 and P2X5 as the important molecules in sensory afferent of bladder in female overactive bladder (OAB) patients with the bladder hyperesthesia. Sixty-eight OAB patients admitted in Southwest Hospital affiliated to the Third Military Medical University during September, 2011-December, 2012 were selected and included in the experimental group (OAB group) and 30 healthy volunteers during the same period were included as the control group. We recorded voiding diary and urodynamic results, and immunohistochemistry analysis was used to detect P2X2 and P2X5 receptor in interstitial cell of Caja (ICC) in bladder tissue of female OAB patients and healthy volunteers, to tentatively explore the effect of P2X2 and P2X5 in bladder hyperesthesia. Urodynamic study has important diagnostic value in the diagnosis and differential diagnosis of OAB. P2X2 receptor was significantly up-regulated in bladder ICC in OAB group. The blockage of P2X2 receptor could significantly inhibit the contraction of bladder muscle strips, decrease the bladder pressure and the electric discharge of pelvic nerve. PET and urodynamic study showed that micturition desire sense in PAG area of pons in OAB patients was significantly increased compared with the control group. The up-regulation of P2X2 in ICC is an important factor to cause bladder hyperesthesia in OAB patients. PET and urodynamic study indicate that the bladder-originated nervous impulses are important cause of OAB. This study provides a basis for the study of P2X2 receptor in ICC in bladder hyperesthesia of OAB patients.

  13. Thermodynamics-based design of microbial cell factories for anaerobic product formation.

    PubMed

    Cueto-Rojas, Hugo F; van Maris, A J A; Wahl, S Aljoscha; Heijnen, J J

    2015-09-01

    The field of metabolic engineering has delivered new microbial cell factories and processes for the production of different compounds including biofuels, (di)carboxylic acids, alcohols, and amino acids. Most of these processes are aerobic, with few exceptions (e.g., alcoholic fermentation), and attention is focused on assembling a high-flux product pathway with a production limit usually set by the oxygen transfer rate. By contrast, anaerobic product synthesis offers significant benefits compared to aerobic systems: higher yields, less heat generation, reduced biomass production, and lower mechanical energy input, which can significantly reduce production costs. Using simple thermodynamic calculations, we demonstrate that many products can theoretically be produced under anaerobic conditions using several conventional and non-conventional substrates.

  14. Application of multi-factorial design of experiments to successfully optimize immunoassays for robust measurements of therapeutic proteins.

    PubMed

    Ray, Chad A; Patel, Vimal; Shih, Judy; Macaraeg, Chris; Wu, Yuling; Thway, Theingi; Ma, Mark; Lee, Jean W; Desilva, Binodh

    2009-02-20

    Developing a process that generates robust immunoassays that can be used to support studies with tight timelines is a common challenge for bioanalytical laboratories. Design of experiments (DOEs) is a tool that has been used by many industries for the purpose of optimizing processes. The approach is capable of identifying critical factors and their interactions with a minimal number of experiments. The challenge for implementing this tool in the bioanalytical laboratory is to develop a user-friendly approach that scientists can understand and apply. We have successfully addressed these challenges by eliminating the screening design, introducing automation, and applying a simple mathematical approach for the output parameter. A modified central composite design (CCD) was applied to three ligand binding assays. The intra-plate factors selected were coating, detection antibody concentration, and streptavidin-HRP concentrations. The inter-plate factors included incubation times for each step. The objective was to maximize the logS/B (S/B) of the low standard to the blank. The maximum desirable conditions were determined using JMP 7.0. To verify the validity of the predictions, the logS/B prediction was compared against the observed logS/B during pre-study validation experiments. The three assays were optimized using the multi-factorial DOE. The total error for all three methods was less than 20% which indicated method robustness. DOE identified interactions in one of the methods. The model predictions for logS/B were within 25% of the observed pre-study validation values for all methods tested. The comparison between the CCD and hybrid screening design yielded comparable parameter estimates. The user-friendly design enables effective application of multi-factorial DOE to optimize ligand binding assays for therapeutic proteins. The approach allows for identification of interactions between factors, consistency in optimal parameter determination, and reduced method

  15. A Classroom of Polymer Factories.

    ERIC Educational Resources Information Center

    Harris, Mary E.; Van Natta, Sandra

    1998-01-01

    Provides an activity in which students create small classroom factories and investigate several aspects of production including design, engineering, quality control, waste management, packaging, shipment, and communication. (DDR)

  16. Slime Factory.

    ERIC Educational Resources Information Center

    Fowler, Marilyn L.

    1992-01-01

    Describes a classroom activity using slime, a colloid: it behaves like both a solid and liquid. Explains how slime can be produced from guar gum. An activity where students work in teams and become a slime factory is presented. (PR)

  17. The Injection System of the INFN-SuperB Factory Project: Preliminary Design

    SciTech Connect

    Boni, Roberto; Guiducci, Susanna; Preger, Miro; Raimondi, Pantaleo; Chance, Antoine; Dadoun, Olivier; Poirier, Freddy; Variola, Alessandro; Seeman, John; /SLAC

    2012-07-05

    The ultra high luminosity B-factory (SuperB) project of INFN requires a high performance and reliable injection system, providing electrons at 4 GeV and positrons at 7 GeV, to fulfil the very tight requirements of the collider. Due to the short beam lifetime, continuous injection of electron and positron bunches in both LER and HER rings is necessary to maintain an high average luminosity. Polarized electrons are required for experiments and must be delivered by the injection system, due to the beam lifetime shorter than the ring polarization build-up: they will be produced by means of a SLAC-SLC polarized gun. The emittance and the energy spread of the e{sup -}/e{sup +} beams are reduced in a 1 GeV Damping Ring (DR) before injection in the main rings. Two schemes for positron production are under study, one with e{sup -}/e{sup +} conversion at low energy (< 1 Gev) and one with conversion at 6 GeV and a recirculation line to bring the positrons back to the DR. Acceleration through the Linac is provided by a 2856 MHz RF system made of travelling wave (TW), room temperature accelerating structures.

  18. A review of metabolic and enzymatic engineering strategies for designing and optimizing performance of microbial cell factories

    PubMed Central

    Fisher, Amanda K.; Freedman, Benjamin G.; Bevan, David R.; Senger, Ryan S.

    2014-01-01

    Microbial cell factories (MCFs) are of considerable interest to convert low value renewable substrates to biofuels and high value chemicals. This review highlights the progress of computational models for the rational design of an MCF to produce a target bio-commodity. In particular, the rational design of an MCF involves: (i) product selection, (ii) de novo biosynthetic pathway identification (i.e., rational, heterologous, or artificial), (iii) MCF chassis selection, (iv) enzyme engineering of promiscuity to enable the formation of new products, and (v) metabolic engineering to ensure optimal use of the pathway by the MCF host. Computational tools such as (i) de novo biosynthetic pathway builders, (ii) docking, (iii) molecular dynamics (MD) and steered MD (SMD), and (iv) genome-scale metabolic flux modeling all play critical roles in the rational design of an MCF. Genome-scale metabolic flux models are of considerable use to the design process since they can reveal metabolic capabilities of MCF hosts. These can be used for host selection as well as optimizing precursors and cofactors of artificial de novo biosynthetic pathways. In addition, recent advances in genome-scale modeling have enabled the derivation of metabolic engineering strategies, which can be implemented using the genomic tools reviewed here as well. PMID:25379147

  19. On Association Coefficients for 2x2 Tables and Properties that Do Not Depend on the Marginal Distributions

    ERIC Educational Resources Information Center

    Warrens, Matthijs J.

    2008-01-01

    We discuss properties that association coefficients may have in general, e.g., zero value under statistical independence, and we examine coefficients for 2x2 tables with respect to these properties. Furthermore, we study a family of coefficients that are linear transformations of the observed proportion of agreement given the marginal…

  20. Students' Attitudes and Perceived Purposes of Physical Education in Singapore: Perspectives from a 2 x 2 Achievement Goal Framework

    ERIC Educational Resources Information Center

    Wang, C. K.; Lim, B. S.; Aplin, N. G.; Chia, Y. H. M.; McNeill, M.; Tan, W. K.

    2008-01-01

    The aim of the present study was to re-examine the relationships between achievement goals and perceived purposes of PE, perceived motivational climates, attitudes towards PE teachers and affective outcomes using the 2 x 2 achievement goal framework. Questionnaires were completed by 493 secondary school students (222 males, 262 females, 9 missing)…

  1. Characterization of a Solid Oxide Fuel Cell Gas Turbine Hybrid System Based on a Factorial Design of Experiments Using Hardware Simulation

    SciTech Connect

    Restrepo, Bernardo; Banta, Larry E; Tucker, David

    2012-10-01

    A full factorial experimental design and a replicated fractional factorial design were carried out using the Hybrid Performance (HyPer) project facility installed at the National Energy Technology Laboratory (NETL), U.S. Department of Energy to simulate gasifer/fuel cell/turbine hybrid power systems. The HyPer facility uses hardware in the loop (HIL) technology that couples a modified recuperated gas turbine cycle with hardware driven by a solid oxide fuel cell model. A 34 full factorial design (FFD) was selected to study the effects of four factors: cold-air, hot-air, bleed-air bypass valves, and the electric load on different parameters such as cathode and turbine inlet temperatures, pressure and mass flow. The results obtained, compared with former results where the experiments were made using one-factor-at-a-time (OFAT), show that no strong interactions between the factors are present in the different parameters of the system. This work also presents a fractional factorial design (ffd) 34-2 in order to analyze replication of the experiments. In addition, a new envelope is described based on the results of the design of experiments (DoE), compared with OFAT experiments, and analyzed in an off-design integrated fuel cell/gas turbine framework. This paper describes the methodology, strategy, and results of these experiments that bring new knowledge concerning the operating state space for this kind of power generation system.

  2. Plant Factory

    NASA Astrophysics Data System (ADS)

    Ikeda, Hideo

    Recently, much attention is paid on the plant factory, as it enable to grow plants stably under extraordinary climate condition such as high and/or low air temperature and less rain. Lots of questions such as decreasing investing cost, realizing stable plant production and developing new growing technique should be solved for making popular this growing system. However, I think that we can introduce a highly developed Japanese industrial now-how to plant factory system and can produce a business chance to the world market.

  3. A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania.

    PubMed

    Kramer, Randall A; Mboera, Leonard E G; Senkoro, Kesheni; Lesser, Adriane; Shayo, Elizabeth H; Paul, Christopher J; Miranda, Marie Lynn

    2014-05-01

    The optimization of malaria control strategies is complicated by constraints posed by local health systems, infrastructure, limited resources, and the complex interactions between infection, disease, and treatment. The purpose of this paper is to describe the protocol of a randomized factorial study designed to address this research gap. This project will evaluate two malaria control interventions in Mvomero District, Tanzania: (1) a disease management strategy involving early detection and treatment by community health workers using rapid diagnostic technology; and (2) vector control through community-supported larviciding. Six study villages were assigned to each of four groups (control, early detection and treatment, larviciding, and early detection and treatment plus larviciding). The primary endpoint of interest was change in malaria infection prevalence across the intervention groups measured during annual longitudinal cross-sectional surveys. Recurring entomological surveying, household surveying, and focus group discussions will provide additional valuable insights. At baseline, 962 households across all 24 villages participated in a household survey; 2,884 members from 720 of these households participated in subsequent malariometric surveying. The study design will allow us to estimate the effect sizes of different intervention mixtures. Careful documentation of our study protocol may also serve other researchers designing field-based intervention trials. PMID:24840349

  4. A randomized longitudinal factorial design to assess malaria vector control and disease management interventions in rural Tanzania.

    PubMed

    Kramer, Randall A; Mboera, Leonard E G; Senkoro, Kesheni; Lesser, Adriane; Shayo, Elizabeth H; Paul, Christopher J; Miranda, Marie Lynn

    2014-05-16

    The optimization of malaria control strategies is complicated by constraints posed by local health systems, infrastructure, limited resources, and the complex interactions between infection, disease, and treatment. The purpose of this paper is to describe the protocol of a randomized factorial study designed to address this research gap. This project will evaluate two malaria control interventions in Mvomero District, Tanzania: (1) a disease management strategy involving early detection and treatment by community health workers using rapid diagnostic technology; and (2) vector control through community-supported larviciding. Six study villages were assigned to each of four groups (control, early detection and treatment, larviciding, and early detection and treatment plus larviciding). The primary endpoint of interest was change in malaria infection prevalence across the intervention groups measured during annual longitudinal cross-sectional surveys. Recurring entomological surveying, household surveying, and focus group discussions will provide additional valuable insights. At baseline, 962 households across all 24 villages participated in a household survey; 2,884 members from 720 of these households participated in subsequent malariometric surveying. The study design will allow us to estimate the effect sizes of different intervention mixtures. Careful documentation of our study protocol may also serve other researchers designing field-based intervention trials.

  5. Design of a factorial experiment with randomization restrictions to assess medical device performance on vascular tissue

    PubMed Central

    2011-01-01

    Background Energy-based surgical scalpels are designed to efficiently transect and seal blood vessels using thermal energy to promote protein denaturation and coagulation. Assessment and design improvement of ultrasonic scalpel performance relies on both in vivo and ex vivo testing. The objective of this work was to design and implement a robust, experimental test matrix with randomization restrictions and predictive statistical power, which allowed for identification of those experimental variables that may affect the quality of the seal obtained ex vivo. Methods The design of the experiment included three factors: temperature (two levels); the type of solution used to perfuse the artery during transection (three types); and artery type (two types) resulting in a total of twelve possible treatment combinations. Burst pressures of porcine carotid and renal arteries sealed ex vivo were assigned as the response variable. Results The experimental test matrix was designed and carried out as a split-plot experiment in order to assess the contributions of several variables and their interactions while accounting for randomization restrictions present in the experimental setup. The statistical software package SAS was utilized and PROC MIXED was used to account for the randomization restrictions in the split-plot design. The combination of temperature, solution, and vessel type had a statistically significant impact on seal quality. Conclusions The design and implementation of a split-plot experimental test-matrix provided a mechanism for addressing the existing technical randomization restrictions of ex vivo ultrasonic scalpel performance testing, while preserving the ability to examine the potential effects of independent factors or variables. This method for generating the experimental design and the statistical analyses of the resulting data are adaptable to a wide variety of experimental problems involving large-scale tissue-based studies of medical or experimental

  6. A New Interaction Region Design for the Super-B Factory

    SciTech Connect

    Sullivan, Michael; Bertsche, Kirk; Bettoni, Simona; Paoloni, Eugenio; Raimondi, Pantaleo; Vobly, Pavel; /Novosibirsk, IYF

    2012-07-06

    A final focus magnet design that uses super-ferric magnets is introduced for the SuperB interaction region. The baseline design has air-core super-conducting quadrupoles. This idea instead uses super-conducting wire in an iron yoke. The iron is in the shape of a Panofsky quadrupole and this allows two quadrupoles to be side-by-side with no intervening iron as long as the gradients of the two quads are equal. This feature allows us to move in as close as possible to the collision point and minimize the beta functions in the interaction region. The superferric design has advantages as well as drawbacks and we will discuss these in the paper.

  7. An Application of Brunerian Theory to Instructional Simulation: Spatial Visualization, Factorial Research Designs, and Wooden Blocks.

    ERIC Educational Resources Information Center

    Winer, Laura R.

    A study was conducted to test the hypothesis that Brunerian learning theory can provide the instructional designer with a framework for developing effective learning materials. To determine three levels of spatial ability, two standardized tests--the Spatial Visualization Test (SVT) of the Dailey Vocational Tests and part VI of the…

  8. PEP-II Asymmetric B Factory: Designs Update and R& D Results

    SciTech Connect

    Zisman, M

    2004-07-22

    PEP-II, a 9 GeV x 3.1 GeV e{sup +}e{sup -} collider with a design luminosity of 3 x 10{sup 33} cm{sup -2}s{sup -1}, was proposed jointly by SLAC, LBL, and LLNL. Recent efforts have continued towards an optimized design. In addition, an aggressive R&D program is under way to validate our design choices. Fabrication of a low-power prototype RF cavity is complete, and impedance measurements are beginning. A 500-kW, 476-MHz klystron has been completed; it will be used for testing both high-power RF windows and a prototype high-power cavity (now under design in collaboration with Chalk River Laboratory). Vacuum studies have demonstrated that chambers with suitable photodesorption properties can be fabricated. A mock-up of the two-ring arc area has been completed and used to investigate alignment and stability issues. The PEP-II project is ready to begin construction as soon as funds become available.

  9. Recirculating linacs for a neutrino factory - Arc optics design and optimization

    SciTech Connect

    Alex Bogacz; Valeri Lebedev

    2001-10-21

    A conceptual lattice design for a muon accelerator based on recirculating linacs (Nucl. Instr. and Meth. A 472 (2001) 499, these proceedings) is presented here. The challenge of accelerating and transporting a large phase space of short-lived muons is answered here by presenting a proof-of-principle lattice design for a recirculating linac accelerator. It is the centerpiece of a chain of accelerators consisting of a 3GeV linac and two consecutive recirculating linear accelerators, which facilitates acceleration starting after ionization cooling at 190MeV/c and proceeding to 50GeV. Beam transport issues for large-momentum-spread beams are accommodated by appropriate lattice design choices. The resulting arc optics is further optimized with a sextupole correction to suppress chromatic effects contributing to the emittance dilution. The presented proof-of-principle design of the arc optics with horizontal separation of multi-pass beams can be extended to all passes in both recirculating linacs.

  10. Recirculating linacs for a neutrino factory - Arc optics design and optimization

    SciTech Connect

    Valeri Lebedev; S. Bogacz

    2001-10-25

    A conceptual lattice design for a muon accelerator based on recirculating linacs (Nucl. Instr. and Meth. A 472 (2001) 499, these proceedings) is presented here. The challenge of accelerating and transporting a large phase space of short-lived muons is answered here by presenting a proof-of-principle lattice design for a recirculating linac accelerator. It is the centerpiece of a chain of accelerators consisting of a 3 GeV linac and two consecutive recirculating linear accelerators, which facilitates acceleration starting after ionization cooling at 190 MeV/c and proceeding to 50 GeV. Beam transport issues for large-momentum-spread beams are accommodated by appropriate lattice design choices. The resulting arc optics is further optimized with a sextupole correction to suppress chromatic effects contributing to the emittance dilution. The presented proof-of-principle design of the arc optics with horizontal separation of multi-pass beams can be extended to all passes in both recirculating linacs.

  11. Removing lead from metallic mixture of waste printed circuit boards by vacuum distillation: factorial design and removal mechanism.

    PubMed

    Li, Xingang; Gao, Yujie; Ding, Hui

    2013-10-01

    The lead removal from the metallic mixture of waste printed circuit boards by vacuum distillation was optimized using experimental design, and a mathematical model was established to elucidate the removal mechanism. The variables studied in lead evaporation consisted of the chamber pressure, heating temperature, heating time, particle size and initial mass. The low-level chamber pressure was fixed at 0.1 Pa as the operation pressure. The application of two-level factorial design generated a first-order polynomial that agreed well with the data for evaporation efficiency of lead. The heating temperature and heating time exhibited significant effects on the efficiency, which was validated by means of the copper-lead mixture experiments. The optimized operating conditions within the region studied were the chamber pressure of 0.1 Pa, heating temperature of 1023 K and heating time of 120 min. After the conditions were employed to remove lead from the metallic mixture of waste printed circuit boards, the efficiency was 99.97%. The mechanism of the effects was elucidated by mathematical modeling that deals with evaporation, mass transfer and condensation, and can be applied to a wider range of metal removal by vacuum distillation.

  12. Enhancement of Solubility of Lamotrigine by Solid Dispersion and Development of Orally Disintegrating Tablets Using 32 Full Factorial Design

    PubMed Central

    Singh, Jatinderpal; Garg, Rajeev; Gupta, Ghanshyam Das

    2015-01-01

    Present investigation deals with the preparation and evaluation of orally disintegrating tablets (ODTs) of lamotrigine using β-cyclodextrin and PVP-K30 as polymers for the preparation of solid dispersion which help in enhancement of aqueous solubility of this BCS CLASS-II drug and sodium starch glycolate (SSG) and crospovidone as a superdisintegrating agent, to reduce disintegration time. The ODTs were prepared by direct compression method. Nine formulations were developed with different ratios of superdisintegrating agents. All the formulations were evaluated for disintegration time, weight variation, hardness, friability, drug content uniformity, wetting time, and in vitro drug release study. In vitro drug release study was performed using United States Pharmacopoeia (USP) type 2 dissolution test apparatus employing paddle stirrer at 50 rpm using 900 mL of 0.1 N HCl maintained at 37°C ± 0.5°C as the dissolution medium. On the basis of evaluation parameters formulations were prepared using β-CD 1 : 1 solid dispersion. Then 32 full factorial design was applied using SSG and crospovidone in different ratios suggested by using design expert 8.0.7.1 and optimized formulation was prepared using amount of SSG and crospovidone as suggested by the software. The optimized formulation prepared had disintegrating time of 15 s, wetting time of 24 s, and % friability of 0.55. PMID:26634173

  13. Design Concept of a Gamma-gamma Higgs Factory Driven by Thin Laser Targets and Energy Recovery Linacs

    SciTech Connect

    Zhang, Yuhong

    2013-06-01

    A gamma-gamma collider has long been considered an option for a Higgs Factory. Such photon colliders usually rely on Compton back-scattering for generating high energy gamma photons and further Higgs bosons through gamma-gamma collisions. The presently existing proposals or design concepts all have chosen a very thick laser target (i.e., high laser photon intensity) for Compton scatterings. In this paper, we present a new design concept of a gamma-gamma collider utilizing a thin laser target (i.e., relatively low photon density), thus leading to a low electron to gamma photon conversion rate. This new concept eliminates most useless and harmful low energy soft gamma photons from multiple Compton scattering so the detector background is improved. It also greatly relaxes the requirement of the high peak power of the laser, a significant technical challenge. A high luminosity for such a gamma-gamma collider can be achieved through an increase of the bunch repetition rate and current of the driven electron beam. Further, multi-pass recirculating linac could greatly reduce the linac cost and energy recovery is required to reduce the needed RF power.

  14. Evaluation of bioaugmentation and biostimulation effects on the treatment of refinery oily sludge using 2(n) full factorial design.

    PubMed

    Jasmine, Jublee; Mukherji, Suparna

    2014-08-01

    Bioremediation approaches for the treatment of oily sludge from a refinery were evaluated using a 2(3) factorial design. The three strategies tested were bioaugmentation with indigenous microbial consortia (MO) isolated from oily sludge, biostimulation with nutrients (NP) and biostimulation with the surfactant Triton X-100 (TX). Eight experimental runs were conducted in triplicate with factor settings ± (high/low) as per the 2(3) design. The main effects and the effects of various interactions of the factors on oil degradation and microbial growth in suspension were evaluated during a 30 day study. Multifactor ANOVA could reveal the significant effects while the normal order score approach failed in this scenario. The main effect of biostimulation with nutrients in the form of nitrate and phosphate, as well as biostimulation with Triton X-100, was positive and significant when both oil degradation and microbial growth in suspension were chosen as the response variables. However, the main effect of bioaugmentation was only significant for oil degradation but was insignificant for microbial growth at a 90% confidence level. The MO-NP binary interaction and the MO-NP-TX ternary interactions were positive and significant, indicating the synergistic effect of these strategies on oil degradation and microbial growth. All other binary interactions were found to be insignificant.

  15. A 2x2 multi-chip reconfigurable MOEMS mask: a stepping stone to large format microshutter arrays for coded aperture applications

    NASA Astrophysics Data System (ADS)

    McNie, Mark E.; Brown, Alan G.; King, David O.; Smith, Gilbert W.; Gordon, Neil T.; Riches, Stephen; Rogers, Stanley

    2010-08-01

    Coded aperture imaging has been used for astronomical applications for several years. Typical implementations used a fixed mask pattern and are designed to operate in the X-Ray or gamma ray bands. Recently applications have emerged in the visible and infra red bands for low cost lens-less imaging systems and system studies have shown that considerable advantages in image resolution may accrue from the use of multiple different images of the same scene - requiring a reconfigurable mask. Previously reported work focused on realising a 2x2cm single chip mask in the mid-IR based on polysilicon micro-optoelectro- mechanical systems (MOEMS) technology and its integration with ASIC drive electronics using conventional wire bonding. It employs interference effects to modulate incident light - achieved by tuning a large array of asymmetric Fabry-Perot optical cavities via an applied voltage and uses a hysteretic row/column scheme for addressing. In this paper we report on the latest results in the mid-IR for the single chip reconfigurable MOEMS mask, trials in scaling up to a mask based on a 2x2 multi-chip array and report on progress towards realising a large format mask comprising 44 MOEMS chips. We also explore the potential of such large, transmissive IR spatial light modulator arrays for other applications and in the current and alternative architectures.

  16. Treatment of municipal landfill leachate by catalytic wet air oxidation: Assessment of the role of operating parameters by factorial design

    SciTech Connect

    Anglada, Angela; Urtiaga, Ane; Ortiz, Inmaculada; Diamadopoulos, Evan

    2011-08-15

    Highlights: > Landfill leachates can be treated effectively by catalytic wet oxidation. > Addition of H{sub 2}O{sub 2} in the presence of transition metals promotes degradation. > Factorial design evaluates the statistically significant operating conditions. > H{sub 2}O{sub 2}, reaction time and temperature are critical in determining performance. - Abstract: The wet air oxidation (WAO) of municipal landfill leachate catalyzed by cupric ions and promoted by hydrogen peroxide was investigated. The effect of operating conditions such as WAO treatment time (15-30 min), temperature (160-200 deg. C), Cu{sup 2+} concentration (250-750 mg L{sup -1}) and H{sub 2}O{sub 2} concentration (0-1500 mg L{sup -1}) on chemical oxygen demand (COD) removal was investigated by factorial design considering a two-stage, sequential process comprising the heating-up of the reactor and the actual WAO. The leachate, at an initial COD of 4920 mg L{sup -1}, was acidified to pH 3 leading to 31% COD decrease presumably due to the coagulation/precipitation of colloidal and other organic matter. During the 45 min long heating-up period of the WAO reactor under an inert atmosphere, COD removal values up to 35% (based on the initial COD value) were recorded as a result of the catalytic decomposition of H{sub 2}O{sub 2} to reactive hydroxyl radicals. WAO at 2.5 MPa oxygen partial pressure advanced treatment further; for example, 22 min of oxidation at 200 deg. C, 250 mg L{sup -1} Cu{sup 2+} and 0-1500 mg L{sup -1} H{sub 2}O{sub 2} resulted in an overall (i.e. including acidification and heating-up) COD reduction of 78%. Amongst the operating variables in question, temperature had the strongest influence on both the heating-up and WAO stages, while H{sub 2}O{sub 2} concentration strongly affected the former and reaction time the latter. Nonetheless, the effects of temperature and H{sub 2}O{sub 2} concentration were found to depend on the concentration levels of catalyst as suggested by the

  17. Growth of an {alpha}-Sn film on an InSb(111) A-(2x2) surface

    SciTech Connect

    Kondo, Daiyu; Sakamoto, Kazuyuki; Shima, Masahide; Takeyama, Wakaba; Nakamura, Kenya; Ono, Kanta; Oshima, Masaharu; Kasukabe, Yoshitaka

    2004-12-15

    We have investigated the initial growth process of {alpha}-Sn films on the In-terminated InSb(111)A-(2x2) surface using low-energy electron diffraction (LEED) and high-resolution core-level photoelectron spectroscopy. Taking the LEED observation and the Sn coverage-dependent integrated intensities of the In 4d, Sb 4d, and Sn 4d core-level spectra into account, we conclude that the {alpha}-Sn film grows epitaxially by a bilayer mode and that there is no interdiffusion of the substrate atoms as suggested in the literature. Furthermore, the coverage-dependent In 4d and Sn 4d core levels indicate that the In vacancy site of InSb(111)A-(2x2) surface is not the preferable Sn absorption site.

  18. High-power RF window design for the PEP-II B Factory

    SciTech Connect

    Neubauer, M.; Hodgson, J.; Ng, C.; Schwarz, H.; Skarpaas, K.; Kroll, N. |; Rimmer, R.

    1994-06-01

    We describe the design of RF windows to transmit up to 500 kW CW to the PEP-II 476 MHz cavities. RF analysis of the windows using high-frequency simulation codes are described. These provide information about the power loss distribution in the ceramic and tim matching properties of the structure. Finite-element analyses of the resulting temperature distribution and thermal stresses are presented. Fabrication methods including a proposed scheme to compensate for thermal expansion s are discussed and hardware tests to validate this approach are described. The effects of surface coatings (intentional and otherwise) and the application of air cooling are considered.

  19. Design Concept for nu-STORM: An Initial Very Low-Energy Neutrino Factory

    SciTech Connect

    Bross, A.; Geer, S.; Liu, A.; Neuffer, D.; Popovic, M.; Ankenbrandt, C.; Roberts, T.; /MUONS Inc., Batavia

    2012-05-01

    We present a design concept for a {nu} source from a STORage ring for Muons ({nu}STORM). In this initial design a high-intensity proton beam produces {approx}5 GeV pions that provide muons that are captured using 'stochastic injection' within a 3.6 GeV racetrack storage ring. In 'stochastic injection', the {approx}5 GeV pion beam is transported from the target into the storage ring, dispersion-matched into a long straight section. (Circulating and injection orbits are separated by momentum.) Decays within that straight section provide muons that are within the {approx}3.6 GeV/c ring momentum acceptance and are stored for the muon lifetime of {approx}1000 turns. Muon (and pion) decays in the long straight sections provide neutrino beams of precisely known flux and flavor that can be used for precision measurements of electron and muon neutrino interactions, and neutrino oscillations or disappearance at L/E = {approx}1m/MeV. The facility is described, and variations are discussed.

  20. Stabilization of the O p2x2 phase on Cu(001) sheltered by wrinkled BN over-layer

    NASA Astrophysics Data System (ADS)

    Kim, Yong-Sung; Ma, Chuanxu; Li, An-Ping; Yoon, Mina

    The 2 √3x √3R45°phase of oxygen (O) on the Cu(001) surface has been observed in scanning tunneling microscopy (STM) measurements. Although the p2x2 phase of O on the Cu(001) surface has been proposed theoretically to be the most stable in O-lean conditions, it has not been observed in experiments for a long time. Recently, the O p2x2 phase has been found in STM on the Cu(001) surface with an overlying BN monolayer. In this theoretical study, we investigate what the role of BN over-layer is to stabilize the O p2x2 phase on the Cu(001) surface. The BN over-layer is lattice-matched with the Cu(001) surface and the BN mono-layer sheet is periodically wrinkled along the BN arm-chair direction and along the [100] or [010] direction on the Cu(001) surface. The interlayer space between the Cu(001) surface and the bulge of the wrinkled BN sheet is found to play as a preferential shelter for O to be adsorbed, and the boundary of the BN inner wall along the [010] or [100] direction makes the p2x2 phase more favorable against the 45°-tilted 2 √3x √3R45°phase of O on the Cu(001) surface. This was supported by Center for Nanophase Materials Sciences, which is a DOE Office of Science User Facility, and the Laboratory Directed Research and Development Program of Oak Ridge National Laboratory, maaged by UT-Battelle, LLC, for the U. S. DOE.

  1. The Old Factory

    ERIC Educational Resources Information Center

    Roman, Harry T.

    2007-01-01

    Technology education is not just about things, systems, and processes. It can also be about history, people, technological change, and impacts on society. In this design challenge, one uses technology education principles and ideas to convert an old factory into a museum and learning center. The challenge with this historical resource is to think…

  2. Design and performance of a compact scanning transmission X-ray microscope at the Photon Factory.

    PubMed

    Takeichi, Y; Inami, N; Suga, H; Miyamoto, C; Ueno, T; Mase, K; Takahashi, Y; Ono, K

    2016-01-01

    We present a new compact instrument designed for scanning transmission X-ray microscopy. It has piezo-driven linear stages, making it small and light. Optical components from the virtual source point to the detector are located on a single optical table, resulting in a portable instrument that can be operated at a general-purpose spectroscopy beamline without requiring any major reconstruction. Careful consideration has been given to solving the vibration problem common to high-resolution microscopy, so as not to affect the spatial resolution determined by the Fresnel zone plate. Results on bacteriogenic iron oxides, single particle aerosols, and rare-earth permanent magnets are presented as examples of its performance under diverse applications. PMID:26827325

  3. Fractional Factorial Experiment Designs to Minimize Configuration Changes in Wind Tunnel Testing

    NASA Technical Reports Server (NTRS)

    DeLoach, Richard; Cler, Daniel L.; Graham, Albert B.

    2002-01-01

    This paper serves as a tutorial to introduce the wind tunnel research community to configuration experiment designs that can satisfy resource constraints in a configuration study involving several variables, without arbitrarily eliminating any of them from the experiment initially. The special case of a configuration study featuring variables at two levels is examined in detail. This is the type of study in which each configuration variable has two natural states - 'on or off', 'deployed or not deployed', 'low or high', and so forth. The basic principles are illustrated by results obtained in configuration studies conducted in the Langley National Transonic Facility and in the ViGYAN Low Speed Tunnel in Hampton, Virginia. The crucial role of interactions among configuration variables is highlighted with an illustration of difficulties that can be encountered when they are not properly taken into account.

  4. Design and performance of a compact scanning transmission X-ray microscope at the Photon Factory.

    PubMed

    Takeichi, Y; Inami, N; Suga, H; Miyamoto, C; Ueno, T; Mase, K; Takahashi, Y; Ono, K

    2016-01-01

    We present a new compact instrument designed for scanning transmission X-ray microscopy. It has piezo-driven linear stages, making it small and light. Optical components from the virtual source point to the detector are located on a single optical table, resulting in a portable instrument that can be operated at a general-purpose spectroscopy beamline without requiring any major reconstruction. Careful consideration has been given to solving the vibration problem common to high-resolution microscopy, so as not to affect the spatial resolution determined by the Fresnel zone plate. Results on bacteriogenic iron oxides, single particle aerosols, and rare-earth permanent magnets are presented as examples of its performance under diverse applications.

  5. Preparation, characterization and optimization of sildenafil citrate loaded PLGA nanoparticles by statistical factorial design

    PubMed Central

    2013-01-01

    Background and the aim of the study The objective of the present study was to formulate and optimize nanoparticles (NPs) of sildenafil-loaded poly (lactic-co-glycolic acid) (PLGA) by double emulsion solvent evaporation (DESE) method. The relationship between design factors and experimental data was evaluated using response surface methodology. Method A Box-Behnken design was made considering the mass ratio of drug to polymer (D/P), the volumetric proportion of the water to oil phase (W/O) and the concentration of polyvinyl alcohol (PVA) as the independent agents. PLGA-NPs were successfully prepared and the size (nm), entrapment efficiency (EE), drug loading (DL) and cumulative release of drug from NPs post 1 and 8 hrs were assessed as the responses. Results The NPs were prepared in a spherical shape and the sizes range of 240 to 316 nm. The polydispersity index of size was lower than 0.5 and the EE (%) and DL (%) varied between 14-62% and 2-6%, respectively. The optimized formulation with a desirability factor of 0.9 was selected and characterized. This formulation demonstrated the particle size of 270 nm, EE of 55%, DL of 3.9% and cumulative drug release of 79% after 12 hrs. In vitro release studies showed a burst release at the initial stage followed by a sustained release of sildenafil from NPs up to 12 hrs. The release kinetic of the optimized formulation was fitted to Higuchi model. Conclusions Sildenafil citrate NPs with small particle size, lipophilic feature, high entrapment efficiency and good loading capacity is produced by this method. Characterization of optimum formulation, provided by an evaluation of experimental data, showed no significant difference between calculated and measured data. PMID:24355133

  6. Optimizing flurbiprofen-loaded NLC by central composite factorial design for ocular delivery

    NASA Astrophysics Data System (ADS)

    Gonzalez-Mira, E.; Egea, M. A.; Souto, E. B.; Calpena, A. C.; García, M. L.

    2011-01-01

    The purpose of this study was to design and optimize a new topical delivery system for ocular administration of flurbiprofen (FB), based on lipid nanoparticles. These particles, called nanostructured lipid carriers (NLC), were composed of a fatty acid (stearic acid (SA)) as the solid lipid and a mixture of Miglyol® 812 and castor oil (CO) as the liquid lipids, prepared by the hot high pressure homogenization method. After selecting the critical variables influencing the physicochemical characteristics of the NLC (the liquid lipid (i.e. oil) concentration with respect to the total lipid (cOil/L (wt%)), the surfactant and the flurbiprofen concentration, on particle size, polydispersity index and encapsulation efficiency), a three-factor five-level central rotatable composite design was employed to plan and perform the experiments. Morphological examination, crystallinity and stability studies were also performed to accomplish the optimization study. The results showed that increasing cOil/L (wt%) was followed by an enhanced tendency to produce smaller particles, but the liquid to solid lipid proportion should not exceed 30 wt% due to destabilization problems. Therefore, a 70:30 ratio of SA to oil (miglyol + CO) was selected to develop an optimal NLC formulation. The smaller particles obtained when increasing surfactant concentration led to the selection of 3.2 wt% of Tween® 80 (non-ionic surfactant). The positive effect of the increase in FB concentration on the encapsulation efficiency (EE) and its total solubilization in the lipid matrix led to the selection of 0.25 wt% of FB in the formulation. The optimal NLC showed an appropriate average size for ophthalmic administration (228.3 nm) with a narrow size distribution (0.156), negatively charged surface (-33.3 mV) and high EE (~90%). The in vitro experiments proved that sustained release FB was achieved using NLC as drug carriers. Optimal NLC formulation did not show toxicity on ocular tissues.

  7. Custom fractional factorial designs to develop atorvastatin self-nanoemulsifying and nanosuspension delivery systems – enhancement of oral bioavailability

    PubMed Central

    Hashem, Fahima M; Al-Sawahli, Majid M; Nasr, Mohamed; Ahmed, Osama AA

    2015-01-01

    Poor water solubility of a drug is a major challenge in drug delivery research and a main cause for limited bioavailability and pharmacokinetic parameters. This work aims to utilize custom fractional factorial design to assess the development of self-nanoemulsifying drug delivery systems (SNEDDS) and solid nanosuspensions (NS) in order to enhance the oral delivery of atorvastatin (ATR). According to the design, 14 experimental runs of ATR SNEDDS were formulated utilizing the highly ATR solubilizing SNEDDS components: oleic acid, Tween 80, and propylene glycol. In addition, 12 runs of NS were formulated by the antisolvent precipitation–ultrasonication method. Optimized formulations of SNEDDS and solid NS, deduced from the design, were characterized. Optimized SNEDDS formula exhibited mean globule size of 73.5 nm, zeta potential magnitude of −24.1 mV, and 13.5 μs/cm of electrical conductivity. Optimized solid NS formula exhibited mean particle size of 260.3 nm, 7.4 mV of zeta potential, and 93.2% of yield percentage. Transmission electron microscopy showed SNEDDS droplets formula as discrete spheres. The solid NS morphology showed flaky nanoparticles with irregular shapes using scanning electron microscopy. The release behavior of the optimized SNEDDS formula showed 56.78% of cumulative ATR release after 10 minutes. Solid NS formula showed lower rate of release in the first 30 minutes. Bioavailability estimation in Wistar albino rats revealed an augmentation in ATR bioavailability, relative to ATR suspension and the commercial tablets, from optimized ATR SNEDDS and NS formulations by 193.81% and 155.31%, respectively. The findings of this work showed that the optimized nanocarriers enhance the oral delivery and pharmacokinetic profile of ATR. PMID:26150693

  8. Enhanced diesel fuel fraction from waste high-density polyethylene and heavy gas oil pyrolysis using factorial design methodology.

    PubMed

    Joppert, Ney; da Silva, Alexsandro Araujo; da Costa Marques, Mônica Regina

    2015-02-01

    Factorial Design Methodology (FDM) was developed to enhance diesel fuel fraction (C9-C23) from waste high-density polyethylene (HDPE) and Heavy Gas Oil (HGO) through co-pyrolysis. FDM was used for optimization of the following reaction parameters: temperature, catalyst and HDPE amounts. The HGO amount was constant (2.00 g) in all experiments. The model optimum conditions were determined to be temperature of 550 °C, HDPE = 0.20 g and no FCC catalyst. Under such conditions, 94% of pyrolytic oil was recovered, of which diesel fuel fraction was 93% (87% diesel fuel fraction yield), no residue was produced and 6% of noncondensable gaseous/volatile fraction was obtained. Seeking to reduce the cost due to high process temperatures, the impact of using higher catalyst content (25%) with a lower temperature (500 °C) was investigated. Under these conditions, 88% of pyrolytic oil was recovered (diesel fuel fraction yield was also 87%) as well as 12% of the noncondensable gaseous/volatile fraction. No waste was produced in these conditions, being an environmentally friendly approach for recycling the waste plastic. This paper demonstrated the usefulness of using FDM to predict and to optimize diesel fuel fraction yield with a great reduction in the number of experiments. PMID:25532672

  9. Amino-functionalization of carbon nanotubes by using a factorial design: human cardiac troponin T immunosensing application.

    PubMed

    Freitas, Tatianny A; Mattos, Alessandra B; Silva, Bárbara V M; Dutra, Rosa F

    2014-01-01

    A simple amino-functionalization method for carbon nanotubes and its application in an electrochemical immunosensor for detection of the human cardiac troponin T are described. Amino-functionalized carbon nanotubes allow oriented antibodies immobilization via their Fc regions, improving the performance of an immunosensor. Herein multiwalled carbon nanotubes were amino-functionalized by using the ethylenediamine reagent and assays were designed by fractional factorial study associated with Doehlert matrix. Structural modifications in the carbon nanotubes were confirmed by Fourier transform infrared spectroscopy. After amino-functionalization the carbon nanotubes were attached to screen-printed carbon electrode and a sandwich-type immunoassay was performed for measuring the cardiac troponin T. The electrochemical measurements were obtained through hydrogen peroxide reaction with peroxidase conjugated to the secondary antibody. Under optimal conditions, troponin T immunosensor was evaluated in serum samples, which showed a broad linear range (0.02 to 0.32 ng mL(-1)) and a low limit of detection, 0.016 ng mL(-1). This amino platform can be properly used as clinical tool for cardiac troponin T detection in the acute myocardial infarction diagnosis.

  10. Enhanced diesel fuel fraction from waste high-density polyethylene and heavy gas oil pyrolysis using factorial design methodology.

    PubMed

    Joppert, Ney; da Silva, Alexsandro Araujo; da Costa Marques, Mônica Regina

    2015-02-01

    Factorial Design Methodology (FDM) was developed to enhance diesel fuel fraction (C9-C23) from waste high-density polyethylene (HDPE) and Heavy Gas Oil (HGO) through co-pyrolysis. FDM was used for optimization of the following reaction parameters: temperature, catalyst and HDPE amounts. The HGO amount was constant (2.00 g) in all experiments. The model optimum conditions were determined to be temperature of 550 °C, HDPE = 0.20 g and no FCC catalyst. Under such conditions, 94% of pyrolytic oil was recovered, of which diesel fuel fraction was 93% (87% diesel fuel fraction yield), no residue was produced and 6% of noncondensable gaseous/volatile fraction was obtained. Seeking to reduce the cost due to high process temperatures, the impact of using higher catalyst content (25%) with a lower temperature (500 °C) was investigated. Under these conditions, 88% of pyrolytic oil was recovered (diesel fuel fraction yield was also 87%) as well as 12% of the noncondensable gaseous/volatile fraction. No waste was produced in these conditions, being an environmentally friendly approach for recycling the waste plastic. This paper demonstrated the usefulness of using FDM to predict and to optimize diesel fuel fraction yield with a great reduction in the number of experiments.

  11. Amidated pectin/sodium carboxymethylcellulose microspheres as a new carrier for colonic drug targeting: Development and optimization by factorial design.

    PubMed

    Gadalla, Hytham H; El-Gibaly, Ibrahim; Soliman, Ghareb M; Mohamed, Fergany A; El-Sayed, Ahmed M

    2016-11-20

    The colon is a promising site for drug targeting owing to its long transit time and mild proteolytic activity. The aim of this study was to prepare new low methoxy amidated pectin/NaCMC microspheres cross-linked by a mixture of Zn(2+) and Al(3+) ions and test their potential for colonic targeting of progesterone. A 2(4) factorial design was carried out to optimize the preparation conditions. High drug entrapment efficiency (82-99%) was obtained and it increased with increasing drug concentration but decreased with increasing polymer concentration. Drug release rate was directly proportional to the microsphere drug content and inversely related to Al(3+) ion concentration. Drug release was minimal during the first 3h but was significantly improved in the presence of 1% rat caecal contents, confirming the microsphere potential for colonic delivery. The microspheres achieved >2.3-fold enhancement of colonic progesterone permeability. These results confirm the viability of the produced microspheres as colon-targeted drug delivery vehicle. PMID:27561525

  12. Abrasive resistance of metastable V-Cr-Mn-Ni spheroidal carbide cast irons using the factorial design method

    NASA Astrophysics Data System (ADS)

    Efremenko, V. G.; Shimizu, K.; Cheiliakh, A. P.; Pastukhova, T. V.; Chabak, Yu. G.; Kusumoto, K.

    2016-06-01

    Full factorial design was used to evaluate the two-body abrasive resistance of 3wt%C-4wt%Mn-1.5wt%Ni spheroidal carbide cast irons with varying vanadium (5.0wt%-10.0wt%) and chromium (up to 9.0wt%) contents. The alloys were quenched at 920°C. The regression equation of wear rate as a function of V and Cr contents was proposed. This regression equation shows that the wear rate decreases with increasing V content because of the growth of spheroidal VC carbide amount. Cr influences the overall response in a complex manner both by reducing the wear rate owing to eutectic carbides (M7C3) and by increasing the wear rate though stabilizing austenite to deformation-induced martensite transformation. This transformation is recognized as an important factor in increasing the abrasive response of the alloys. By analyzing the regression equation, the optimal content ranges are found to be 7.5wt%-10.0wt% for V and 2.5wt%-4.5wt% for Cr, which corresponds to the alloys containing 9vol%-15vol% spheroidal VC carbides, 8vol%-16vol% M7C3, and a metastable austenite/martensite matrix. The wear resistance is 1.9-2.3 times that of the traditional 12wt% V-13wt% Mn spheroidal carbide cast iron.

  13. A pilot human pharmacokinetic study and influence of formulation factors on orodispersible tablet incorporating meloxicam solid dispersion using factorial design.

    PubMed

    Aboelwafa, Ahmed A; Fahmy, Rania H

    2012-01-01

    Meloxicam (MLX) suffers from poor aqueous solubility leading to slow absorption following oral administration; hence, immediate release MLX tablet is unsuitable in the treatment of acute pain. This study aims to overcome such a drawback by increasing MLX solubility and dissolution using PEG solid dispersion (SD), then, to investigate the feasibility of incorporating the SD into orodispersible tablets (ODTs). A 2(3) full factorial design was employed to investigate the influence of three formulation variables on MLX ODTs. The selected factors: camphor (X(1)) as pore-forming material, and croscarmellose sodium (X(2)) as superdisintegrant, showed significant positive influence, while PEG content (X(3)) was proved to negatively affect both disintegration and wetting times. In addition, isomalt increased disintegration and wetting times when compared to mannitol as diluents. The pharmacokinetic assessment of the optimum ODT formulation in healthy human subjects proved that the faster MLX dissolution by using PEG solid dispersion at pH 6.8 resulted in more rapid absorption of MLX. The rate of absorption of MLX from ODT was significantly faster (p = 0.030) with a significantly higher peak plasma concentration (P = 0.037) when compared to the marketed immediate release MLX tablet with a mean oral disintegration time of 17 ± 3 s.

  14. Synergistic Effect of Hydrotrope and Surfactant on Solubility and Dissolution of Atorvastatin Calcium: Screening Factorial Design Followed by Ratio Optimization

    PubMed Central

    Patel, V. F.; Sarai, J.

    2014-01-01

    The present study was aimed at investigating the effect of hydrotrope and surfactant on poor solubility of atorvastatin calcium. Excipients screening followed by factorial design was performed to study effect of excipients and manufacturing methods on solubility of drug. Three independent factors (carrier, surfactant and manufacturing method) were evaluated at two levels using solubility as a dependant variable. Solid-state characterisation was performed using Fourier transform infrared spectroscopy and differential scanning calorimetry. Optimised complex were incorporated into orally disintegrating micro tablets and in vitro dissolution test was performed. Nicotinamide, Plasdone and sodium dodecyl sulphate were emerged as promising excipients from excipient screening. General regression analysis revealed only the type of carrier has significantly enhanced (P<0.05) the solubility of drug while other factors were found to be nonsignificant. Ratio optimisation trial revealed that drug to nicotinamide ratio is more critical in enhancing the solubility of drug (40 fold increases in solubility compared to pure drug) in comparison to drug-surfactant ratio; however the presence of surfactant deemed essential. Significantly higher rate and extent of dissolution was observed from solid dispersion complex and tablets compared to dissolution of pure drug (P<0.05). Study revealed hydrotrope and surfactant have synergistic effect on solubility and dissolution of atorvastatin calcium and this can be explored further. PMID:25593381

  15. Amino-Functionalization of Carbon Nanotubes by Using a Factorial Design: Human Cardiac Troponin T Immunosensing Application

    PubMed Central

    Freitas, Tatianny A.; Mattos, Alessandra B.; Silva, Bárbara V. M.; Dutra, Rosa F.

    2014-01-01

    A simple amino-functionalization method for carbon nanotubes and its application in an electrochemical immunosensor for detection of the human cardiac troponin T are described. Amino-functionalized carbon nanotubes allow oriented antibodies immobilization via their Fc regions, improving the performance of an immunosensor. Herein multiwalled carbon nanotubes were amino-functionalized by using the ethylenediamine reagent and assays were designed by fractional factorial study associated with Doehlert matrix. Structural modifications in the carbon nanotubes were confirmed by Fourier transform infrared spectroscopy. After amino-functionalization the carbon nanotubes were attached to screen-printed carbon electrode and a sandwich-type immunoassay was performed for measuring the cardiac troponin T. The electrochemical measurements were obtained through hydrogen peroxide reaction with peroxidase conjugated to the secondary antibody. Under optimal conditions, troponin T immunosensor was evaluated in serum samples, which showed a broad linear range (0.02 to 0.32 ng mL−1) and a low limit of detection, 0.016 ng mL−1. This amino platform can be properly used as clinical tool for cardiac troponin T detection in the acute myocardial infarction diagnosis. PMID:25133185

  16. Modelling aluminium leaching into food from different foodware materials with multi-level factorial design of experiments.

    PubMed

    Fekete, Veronika; Deconinck, Eric; Bolle, Fabien; Van Loco, Joris

    2012-08-01

    To estimate the contribution of aluminium (Al) leaching from different materials used for food preparation and serving to the dietary Al intake, Al release from foodware typically used in everyday life was investigated using multilevel factorial design (MFD) of experiments. For Al characterisation, sample preparation and an analytical method using inductively coupled plasma atomic emission spectroscopy was developed and validated. Parameter influence (temperature: x₁, contact time: x₂, pH: x₃, salt concentration: x₄, viscosity: x₅), was evaluated with analysis of variance suggesting that the influence of viscosity is not significant compared to the other four studied parameters. Therefore, predictive, exponential quadratic regression models were established with x₁-x₄. Cross-validation and a set of independent experiments in real food products were used to test the prediction force of the different models. They both suggest that the quality of the models established for Al foil, Al plate and ceramic ware is satisfactory, but less good for glassware and stainless steel. Indeed, in the studied conditions, leaching from these latter food wares was often close to or even below the limit of quantification suggesting that the principal sources of Al intake from food contact materials during food processing are utensils made of Al and ceramic ware. PMID:22656325

  17. Background species effect on aqueous arsenic removal by nano zero-valent iron using fractional factorial design.

    PubMed

    Tanboonchuy, Visanu; Grisdanurak, Nurak; Liao, Chih-Hsiang

    2012-02-29

    This study describes the removal of arsenic species in groundwater by nano zero-valent iron process, including As(III) and As(V). Since the background species may inhibit or promote arsenic removal. The influence of several common ions such as phosphate (PO4(3-)), bicarbonate (HCO3-)), sulfate (SO4(2-)), calcium (Ca2+), chloride (Cl-), and humic acid (HA) were selected to evaluate their effects on arsenic removal. In particular, a 2(6-2) fractional factorial design (FFD) was employed to identify major or interacting factors, which affect arsenic removal in a significant way. As a result of FFD evaluation, PO4(3-) and HA play the role of inhibiting arsenic removal, while Ca2+ was observed to play the promoting one. As for HCO3- and Cl-, the former one inhibits As(III) removal, whereas the later one enhances its removal; on the other hand, As(V) removal was affected only slightly in the presence of HCO3- or Cl-. Hence, it was suggested that the arsenic removal by the nanoiron process can be improved through pretreatment of PO4(3-) and HA. In addition, for the groundwater with high hardness, the nanoiron process can be an advantageous option because of enhancing characteristics of Ca2+. PMID:22245511

  18. A comprehensive factorial design study of variables affecting CaCO3 scaling under magnetic water treatment.

    PubMed

    Alimi, Fathi; Boubakri, Ali; Tlili, Mohamed M; Ben Amor, Mohamed

    2014-01-01

    Magnetic water treatment (MWT) could be an interesting alternative to chemical treatment to prevent scaling and has been used as an antiscaling treatment for domestic and industrial equipment. A two level-three factor (2(3)) full factorial design was used to evaluate the effects of pH (6-7.5), flow rate (0.54-0.94) and application of a magnetic field on the induction time (IT), total precipitation (TP) rate and homogeneous precipitation (HP) rate of calcium carbonate (CaCO3) scale from hard water. The experimental results and statistical analysis show that the pH, flow rate and interaction between pH and magnetic field have negative effects on IT response. In the case of TP rate response, the magnitude of the main influence is attributed to the magnetic field, followed by pH value and their interaction. Flow rate and pH value have a negative effect on HP rate response, but their interaction has a positive effect. Within these factor ranges, these studied responses predicted by the models were in good agreement with the experimental values. The coefficient of determination (R(2)) for reduction time, TP ratio and HP ratio were 97.8%, 99.12% and 99.92%, respectively. These results were analyzed statistically using Minitab 15.

  19. Improvement in antihypertensive and antianginal effects of felodipine by enhanced absorption from PLGA nanoparticles optimized by factorial design.

    PubMed

    Shah, Umang; Joshi, Garima; Sawant, Krutika

    2014-02-01

    Objective of the present investigation was to enhance the bioavailability of felodipine by targeting the M cells of Peyer's patches using PLGA nanoparticles (NPs). Felodipine exhibits poor bioavailability due to limited aqueous solubility and extensive first pass metabolism. NPs were prepared using nanoprecipitation and optimized by 3(2) factorial design. Particle size (PS) and entrapment efficiency (% EE) were dependent on Drug/PLGA ratio (X1) and Pluronic F-68 (X2) concentration. % EE, PS and Zeta potential for optimized batch were 91.56±3.21%, 161.3±2.23 nm and -25.7±2.52 mV respectively. DSC, XRD and FTIR studies confirmed compatibility of PLGA and drug. TEM image confirmed the spherical shape. The in vitro and ex vivo studies using rat stomach and intestinal segment confirmed sustained release from NPs. Pharmacodynamic studies in rats showed control of blood pressure and ECG changes for extended duration. Hence, NPs can be a suitable alternative to the current available therapy in hypertension and angina by enhancing the bioavailability. PMID:24411363

  20. Electrochemical oxidation of table olive processing wastewater over boron-doped diamond electrodes: treatment optimization by factorial design.

    PubMed

    Deligiorgis, Anastasios; Xekoukoulotakis, Nikolaos P; Diamadopoulos, Evan; Mantzavinos, Dionissios

    2008-02-01

    The electrochemical treatment of an effluent from edible olive processing over boron-doped diamond electrodes was investigated. The effect of operating conditions, such as initial organic loading (from 1340 to 5370 mg/L chemical oxygen demand (COD)), reaction time (from 30 to 120 min), current intensity (from 5 to 14 A), initial pH (from 3 to 7) and the use of 500 mg/L H2O2 as an additional oxidant, on treatment efficiency was assessed implementing a factorial experimental design. Of the five parameters tested, the first three had a considerable effect on COD and total phenols removal, while the other two were statistically insignificant. In most cases, high levels of phenols degradation and decolorization were achieved followed by moderate mineralization. The analysis was repeated at more intense conditions, i.e., initial COD up to 10,000 mg/L, reaction times up to 240 min and current up to 30 A; at this level, the effect of treatment time and applied current was far more important than the starting COD concentration. Treatment for 14 h at optimal conditions (30 A and an initial loading of about 10,000 mg/L) led to 73% COD removal with a zero-order kinetic constant of 8.5mg/(L min) and an energy consumption efficiency of 16.3 g COD/(m3 A h). PMID:17923146

  1. Fractional Factorial Design of MALDI-TOF-MS Sample Preparations for the Optimized Detection of Phospholipids and Acylglycerols.

    PubMed

    AlMasoud, Najla; Correa, Elon; Trivedi, Drupad K; Goodacre, Royston

    2016-06-21

    Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has successfully been used for the analysis of high molecular weight compounds, such as proteins and nucleic acids. By contrast, analysis of low molecular weight compounds with this technique has been less successful due to interference from matrix peaks which have a similar mass to the target analyte(s). Recently, a variety of modified matrices and matrix additives have been used to overcome these limitations. An increased interest in lipid analysis arose from the feasibility of correlating these components with many diseases, e.g. atherosclerosis and metabolic dysfunctions. Lipids have a wide range of chemical properties making their analysis difficult with traditional methods. MALDI-TOF-MS shows excellent potential for sensitive and rapid analysis of lipids, and therefore this study focuses on computational-analytical optimization of the analysis of five lipids (4 phospholipids and 1 acylglycerol) in complex mixtures using MALDI-TOF-MS with fractional factorial design (FFD) and Pareto optimality. Five different experimental factors were investigated using FFD which reduced the number of experiments performed by identifying 720 key experiments from a total of 8064 possible analyses. Factors investigated included the following: matrices, matrix preparations, matrix additives, additive concentrations, and deposition methods. This led to a significant reduction in time and cost of sample analysis with near optimal conditions. We discovered that the key factors used to produce high quality spectra were the matrix and use of appropriate matrix additives. PMID:27228355

  2. Design and Initial Commissioning of Beam Diagnostics for the PEP-II B Factory.

    NASA Astrophysics Data System (ADS)

    Fisher, A. S.; Alzofon, D.; Arnett, D.; Bong, E. L.; Brugnoletti, B.; Collins, B.; Daly, E.; Gioumousis, A.; Johnson, R.; Kulikov, A.; Kurita, N.; Langton, J.; McCormick, D.; Noriega, R.; Smith, S.; Smith, V.; Stege, R.; Bjork, M.; Chin, M.; Hinkson, J.; McGill, R.; Suwada, T.

    1997-05-01

    PEP-II is a 2.2-km-circumference collider with a 2.1-A, 3.1-GeV positron ring (the Low-Energy Ring) 1 m above a 1-A, 9-GeV electron ring (the High-Energy Ring); both are designed for 3 A maximum. We will describe the beam diagnostics and present initial measurements from HER commissioning, expected to start in March 1997. LER commissioning will follow in 1998. The beam size and pulse duration are measured using near-UV synchrotron light extracted by grazing-incidence mirrors that must withstand up to 200 W/cm. To measure the charge in every bucket at 60 Hz with an accuracy of ≈0.5%, the sum signal from a set of 4 pickup buttons is digitized and averaged over 256 samples per bucket. The sum is normalized to the ring current, measured by a DC current transformer. The 300 beam-position monitors per ring are multiplexed to share 171 processor modules, which use DSPs for recording positions over 1024 turns and for calibration. For diagnostics and machine protection, 100 photomultiplier-based Cherenkov detectors measure beam losses and abort the beam in case of high loss.

  3. Peer support for family carers of people with dementia, alone or in combination with group reminiscence in a factorial design: study protocol for a randomised controlled trial

    PubMed Central

    2011-01-01

    Background Peer support interventions can improve carer wellbeing and interventions that engage both the carer and person with dementia can have significant mutual benefits. Existing research has been criticised for inadequate rigour of design or reporting. This paper describes the protocol for a complex trial that evaluates one-to-one peer support and a group reminiscence programme, both separately and together, in a factorial design. Design A 2 × 2 factorial multi-site randomised controlled trial of individual peer support and group reminiscence interventions for family carers and people with dementia in community settings in England, addressing both effectiveness and cost-effectiveness. Discussion The methods described in this protocol have implications for research into psychosocial interventions, particularly complex interventions seeking to test both individual and group approaches. Trial Registration ISRCTN37956201 PMID:21917187

  4. Nanoemulsions containing a synthetic chalcone as an alternative for treating cutaneous leshmaniasis: optimization using a full factorial design

    PubMed Central

    de Mattos, Cristiane Bastos; Argenta, Débora Fretes; Melchiades, Gabriela de Lima; Sechini Cordeiro, Marlon Norberto; Tonini, Maiko Luis; Moraes, Milene Hoehr; Weber, Tanara Beatriz; Roman, Silvane Souza; Nunes, Ricardo José; Teixeira, Helder Ferreira; Steindel, Mário; Koester, Letícia Scherer

    2015-01-01

    Nanoemulsions are drug delivery systems that may increase the penetration of lipophilic compounds through the skin, enhancing their topical effect. Chalcones are compounds of low water solubility that have been described as promising molecules for the treatment of cutaneous leishmaniasis (CL). In this context, the aim of this work was to optimize the development of a nanoemulsion containing a synthetic chalcone for CL treatment using a 22 full factorial design. The formulations were prepared by spontaneous emulsification and the experimental design studied the influence of two independent variables (type of surfactant – soybean lecithin or sorbitan monooleate and type of co-surfactants – polysorbate 20 or polysorbate 80) on the physicochemical characteristics of the nanoemulsions, as well as on the skin permeation/retention of the synthetic chalcone in porcine skin. In order to evaluate the stability of the systems, the antileishmanial assay was performed against Leishmania amazonensis 24 hours and 60 days after the preparation of the nanoemulsions. The formulation composed of soybean lecithin and polysorbate 20 presented suitable physicochemical characteristics (droplet size 171.9 nm; polydispersity index 0.14; zeta potential −39.43 mV; pH 5.16; and viscosity 2.00 cP), drug content (91.09%) and the highest retention in dermis (3.03 µg·g−1) – the main response of interest – confirmed by confocal microscopy. This formulation also presented better stability of leishmanicidal activity in vitro against L. amazonensis amastigote forms (half maximal inhibitory concentration value 0.32±0.05 µM), which confirmed the potential of the nanoemulsion soybean lecithin and polysorbate 20 for CL treatment. PMID:26366075

  5. Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies.

    PubMed

    Shcherbatko, Anatoly; Foletti, Davide; Poulsen, Kris; Strop, Pavel; Zhu, Guoyun; Hasa-Moreno, Adela; Melton Witt, Jody; Loo, Carole; Krimm, Stellanie; Pios, Ariel; Yu, Jessica; Brown, Colleen; Lee, John K; Stroud, Robert; Rajpal, Arvind; Shelton, David

    2016-06-01

    Purinergic homomeric P2X3 and heteromeric P2X2/3 receptors are ligand-gated cation channels activated by ATP. Both receptors are predominantly expressed in nociceptive sensory neurons, and an increase in extracellular ATP concentration under pathological conditions, such as tissue damage or visceral distension, induces channel opening, membrane depolarization, and initiation of pain signaling. Hence, these receptors are considered important therapeutic targets for pain management, and development of selective antagonists is currently progressing. To advance the search for novel analgesics, we have generated a panel of monoclonal antibodies directed against human P2X3 (hP2X3). We have found that these antibodies produce distinct functional effects, depending on the homomeric or heteromeric composition of the target, its kinetic state, and the duration of antibody exposure. The most potent antibody, 12D4, showed an estimated IC50 of 16 nm on hP2X3 after short term exposure (up to 18 min), binding to the inactivated state of the channel to inhibit activity. By contrast, with the same short term application, 12D4 potentiated the slow inactivating current mediated by the heteromeric hP2X2/3 channel. Extending the duration of exposure to ∼20 h resulted in a profound inhibition of both homomeric hP2X3 and heteromeric hP2X2/3 receptors, an effect mediated by efficient antibody-induced internalization of the channel from the plasma membrane. The therapeutic potential of mAb12D4 was assessed in the formalin, complete Freund's adjuvant, and visceral pain models. The efficacy of 12D4 in the visceral hypersensitivity model indicates that antibodies against P2X3 may have therapeutic potential in visceral pain indications. PMID:27129281

  6. Factorial designed 5-fluorouracil-loaded microsponges and calcium pectinate beads plugged in hydroxypropyl methylcellulose capsules for colorectal cancer

    PubMed Central

    Gupta, Ankita; Tiwari, Gaurav; Tiwari, Ruchi; Srivastava, Rishabh

    2015-01-01

    Introduction: The work was aimed to develop an enteric-coated hydroxypropyl methylcellulose (HPMC) capsules (ECHC) plugged with 5-fluorouracil (5-FU)-loaded microsponges in combination with calcium pectinate beads. Materials and Methods: The modified quasi-emulsion solvent diffusion method was used to prepare microsponges. A 32 factorial design was employed to study the formulation and the effects of independent variables (volume of organic solvent and Eudragit-RS100 content) on dependent variables (particle size, %entrapment efficiency, and %cumulative drug release). The optimized microsponge (F4) was characterized by scanning electron microscopy, powder X-ray diffraction, and thermogravimetric analysis. F4 was plugged along with the calcium pectinate beads in HPMC capsules coated with enteric polymer Eudragit-L100 (Ed-L100) and/or Eudragit-S100 (Ed-S100) in different proportions. An in vitro release study of ECHC was performed in simulated gastric fluid for 2 h, followed by simulated intestinal fluid for next 6 h and then in simulated colonic fluid (in the presence and absence of pectinase enzyme for further 16 h). The optimized formulation was subjected to in vivo roentgenographic and pharmacokinetic studies in New Zealand white rabbits to analyze the in vivo behavior of the developed colon-targeted capsules. Results: Drug release was retarded on coating with Ed-S100 in comparison to a blend of Ed-S100:Ed-L100 coating. The percentage of 5-FU released at the end of 24 h from ECHC3 was 97.83 ± 0.12% in the presence of pectinase whereas in the control study, it was 40.08 ± 0.02%. Conclusion: Thus, enteric-coated HPMC capsules plugged with 5-FU-loaded microsponges and calcium pectinate beads proved to be a promising dosage form for colon targeting. PMID:26682194

  7. Testing Nelder-Mead Based Repulsion Algorithms for Multiple Roots of Nonlinear Systems via a Two-Level Factorial Design of Experiments

    PubMed Central

    Fernandes, Edite M. G. P.

    2015-01-01

    This paper addresses the challenging task of computing multiple roots of a system of nonlinear equations. A repulsion algorithm that invokes the Nelder-Mead (N-M) local search method and uses a penalty-type merit function based on the error function, known as ‘erf’, is presented. In the N-M algorithm context, different strategies are proposed to enhance the quality of the solutions and improve the overall efficiency. The main goal of this paper is to use a two-level factorial design of experiments to analyze the statistical significance of the observed differences in selected performance criteria produced when testing different strategies in the N-M based repulsion algorithm. The main goal of this paper is to use a two-level factorial design of experiments to analyze the statistical significance of the observed differences in selected performance criteria produced when testing different strategies in the N-M based repulsion algorithm. PMID:25875591

  8. The removal of the indigo carmine dye from aqueous solutions using cross-linked chitosan: evaluation of adsorption thermodynamics using a full factorial design.

    PubMed

    Cestari, Antonio R; Vieira, Eunice F S; Tavares, Andréa M G; Bruns, Roy E

    2008-05-01

    A 2(3) factorial design was employed to evaluate the quantitative removal of the indigo carmine (IC) dye from aqueous solutions on glutaraldehyde cross-linked chitosan. The variables were chitosan masses of 100 and 300 mg, IC concentrations of 2.0 and 5.0 x 10(-5) mol L(-1) and temperatures of 25 and 35 degrees C. The quantitative and energetic adsorption parameters were analyzed statistically using modeling with bilinear equations. The results indicated that increasing the chitosan mass from 100 to 300 mg decreases the IC adsorption/mass ratio (mol g(-1)) whereas a temperature increase of 25-35 degrees C increases it. The principal effect of the IC concentration did not show statistical significance. The factorial experiments demonstrate the existence of a significant antagonistic interaction effect between the chitosan mass and temperature. The adsorption thermodynamic parameters, namely Delta(ads)H, Delta(ads)G, and Delta(ads)S, were determined for all the factorial design results. Endothermic values were found in relation to the Delta(ads)H. The positive Delta(ads)S values indicate that entropy is a driving force for adsorption. The Delta(ads)G values are also significantly affected by important antagonistic and synergistic effects involving all principal and interactive factors. It is concluded that the thermodynamical spontaneity of the IC adsorption parameters are greatly influenced by the interactive factors and not by the temperature changes alone.

  9. 60-GHz optical/wireless MIMO system integrated with optical subcarrier multiplexing and 2x2 wireless communication.

    PubMed

    Lin, Chi-Hsiang; Lin, Chun-Ting; Huang, Hou-Tzu; Zeng, Wei-Siang; Chiang, Shou-Chih; Chang, Hsi-Yu

    2015-05-01

    This paper proposes a 2x2 MIMO OFDM Radio-over-Fiber scheme based on optical subcarrier multiplexing and 60-GHz MIMO wireless transmission. We also schematically investigated the principle of optical subcarrier multiplexing, which is based on a dual-parallel Mach-Zehnder modulator (DP-MZM). In our simulation result, combining two MIMO OFDM signals to drive DP-MZM gives rise to the PAPR augmentation of less than 0.4 dB, which mitigates nonlinear distortion. Moreover, we applied a Levin-Campello bit-loading algorithm to compensate for the uneven frequency responses in the V-band. The resulting system achieves OFDM signal rates of 61.5-Gbits/s with BER of 10(-3) over 25-km SMF transmission followed by 3-m wireless transmission.

  10. Muon Colliders and Neutrino Factories *

    NASA Astrophysics Data System (ADS)

    Geer, Steve

    2009-11-01

    Over the past decade, there has been significant progress in developing the concepts and technologies needed to produce, capture, and accelerate O(1021) muons per year. These developments have paved the way for a new type of neutrino source (neutrino factory) and a new type of very high energy lepton-antilepton collider (muon collider). This article reviews the motivation, design, and research and development for future neutrino factories and muon colliders.

  11. Muon Colliders and Neutrino Factories

    SciTech Connect

    Geer, Steve; /Fermilab

    2009-11-01

    Over the past decade, there has been significant progress in developing the concepts and technologies needed to produce, capture, and accelerate {Omicron}(10{sup 21}) muons per year. These developments have paved the way for a new type of neutrino source (neutrino factory) and a new type of very high energy lepton-antilepton collider (muon collider). This article reviews the motivation, design, and research and development for future neutrino factories and muon colliders.

  12. Muon colliders and neutrino factories

    SciTech Connect

    Geer, S.; /Fermilab

    2010-09-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture and accelerate {Omicron}(10{sup 21}) muons/year. This development prepares the way for a new type of neutrino source (Neutrino Factory) and a new type of very high energy lepton-antilepton collider (Muon Collider). This article reviews the motivation, design and R&D for Neutrino Factories and Muon Colliders.

  13. A Group-Based Mobile Application to Increase Adherence in Exercise and Nutrition Programs: A Factorial Design Feasibility Study

    PubMed Central

    Venkatakrishnan, Anusha; Youngblood, Gregory Michael; Ram, Ashwin; Pirolli, Peter

    2016-01-01

    Background Novel methods of promoting self-monitoring and social support are needed to ensure long-term maintenance of behavior change. In this paper, we directly investigate the effects of group support in an exercise and nutrition program delivered by an mHealth application called Fittle. Objective Our first specific study aim was to explore whether social support improved adherence in wellness programs. Our second specific study aim was to assess whether media types (ePaper vs mobile) were associated with different levels of compliance and adherence to wellness programs. The third aim was to assess whether the use of an mHealth application led to positive changes to participants’ eating behavior, physical activity, and stress level, compared to traditional paper-based programs. Methods A 2 × 2 (eg, Media: Mobile vs ePaper × Group Type: Team vs Solo) factorial design feasibility study was conducted. A sample of 124 volunteers who were interested in improving eating behavior, increasing physical activity, or reducing stress participated in this study. The study duration was 8 weeks. All groups were self-directed with no ongoing human input from the research team. Results Participants in ePaper conditions had higher attrition rates compared to participants in Mobile conditions, χ3 2=9.96, P=.02 (N=124). Participants in Mobile conditions reported their compliance with a much higher frequency closer to the time of challenge activity completion (2-sample Kolmogorov-Smirnov test comparing distributions was highly significant—KS=0.33, P<.001 [N=63]). Participants in ePaper conditions had a much higher frequency of guessing while reporting as compared with those in Mobile conditions—χ1 2=25.25, P<.001 (N=63). Together, these findings suggest that the mobile app allowed a more accurate method to report and track health behaviors over a longer period than traditional ePaper-based diaries or log books. There was a significant difference in the overall compliance

  14. Double P2X2/P2X3 Purinergic Receptor Knockout Mice Do Not Taste NaCl or the Artificial Sweetener SC45647

    PubMed Central

    Eddy, Meghan C.; Eschle, Benjamin K.; Barrows, Jennell; Hallock, Robert M.; Finger, Thomas E.

    2009-01-01

    The P2X ionotropic purinergic receptors, P2X2 and P2X3, are essential for transmission of taste information from taste buds to the gustatory nerves. Mice lacking both P2X2 and P2X3 purinergic receptors (P2X2/P2X3Dbl−/−) exhibit no taste-evoked activity in the chorda tympani and glossopharyngeal nerves when stimulated with taste stimuli from any of the 5 classical taste quality groups (salt, sweet, sour, bitter, and umami) nor do the mice show taste preferences for sweet or umami, or avoidance of bitter substances (Finger et al. 2005. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science. 310[5753]:1495–1499). Here, we compare the ability of P2X2/P2X3Dbl−/− mice and P2X2/P2X3Dbl+/+ wild-type (WT) mice to detect NaCl in brief-access tests and conditioned aversion paradigms. Brief-access testing with NaCl revealed that whereas WT mice decrease licking at 300 mM and above, the P2X2/P2X3Dbl−/− mice do not show any change in lick rates. In conditioned aversion tests, P2X2/P2X3Dbl−/− mice did not develop a learned aversion to NaCl or the artificial sweetener SC45647, both of which are easily avoided by conditioned WT mice. The inability of P2X2/P2X3Dbl−/− mice to show avoidance of these taste stimuli was not due to an inability to learn the task because both WT and P2X2/P2X3Dbl−/− mice learned to avoid a combination of SC45647 and amyl acetate (an odor cue). These data suggest that P2X2/P2X3Dbl−/− mice are unable to respond to NaCl or SC45647 as taste stimuli, mirroring the lack of gustatory nerve responses to these substances. PMID:19833661

  15. AutoPyFactory: A Scalable Flexible Pilot Factory Implementation

    NASA Astrophysics Data System (ADS)

    Caballero, J.; Hover, J.; Love, P.; Stewart, G. A.

    2012-12-01

    The ATLAS experiment at the CERN LHC is one of the largest users of grid computing infrastructure, which is a central part of the experiment's computing operations. Considerable efforts have been made to use grid technology in the most efficient and effective way, including the use of a pilot job based workload management framework. In this model the experiment submits ‘pilot’ jobs to sites without payload. When these jobs begin to run they contact a central service to pick-up a real payload to execute. The first generation of pilot factories were usually specific to a single Virtual Organization (VO), and were bound to the particular architecture of that VO's distributed processing. A second generation provides factories which are more flexible, not tied to any particular VO, and provide new and improved features such as monitoring, logging, profiling, etc. In this paper we describe this key part of the ATLAS pilot architecture, a second generation pilot factory, AutoPyFactory. AutoPyFactory has a modular design and is highly configurable. It is able to send different types of pilots to sites and exploit different submission mechanisms and queue characteristics. It is tightly integrated with the PanDA job submission framework, coupling pilot flow to the amount of work the site has to run. It gathers information from many sources in order to correctly configure itself for a site and its decision logic can easily be updated. Integrated into AutoPyFactory is a flexible system for delivering both generic and specific job wrappers which can perform many useful actions before starting to run end-user scientific applications, e.g., validation of the middleware, node profiling and diagnostics, and monitoring. AutoPyFactory also has a robust monitoring system that has been invaluable in establishing a reliable pilot factory service for ATLAS.

  16. Photoelectron diffraction k-space volumes of the c(2x2) Mn/Ni(100) structure

    SciTech Connect

    Banerjee, S.; Denlinger, J.; Chen, X.

    1997-04-01

    Traditionally, x-ray photoelectron diffraction (XPD) studies have either been done by scanning the diffraction angle for fixed kinetic energy (ADPD), or scanning the kinetic energy at fixed exit angle (EDPD). Both of these methods collect subsets of the full diffraction pattern, or volume, which is the intensity of photoemission as a function of momentum direction and magnitude. With the high density available at the Spectromicroscopy Facility (BL 7.0) {open_quotes}ultraESCA{close_quotes} station, the authors are able to completely characterize the photoelectron diffraction patterns of surface structures, up to several hundred electron volts kinetic energy. This large diffraction `volume` can then be analyzed in many ways. The k-space volume contains as a subset the energy dependent photoelectron diffraction spectra along all emission angles. It also contains individual, hemispherical, diffraction patterns at specific kinetic energies. Other `cuts` through the data set are also possible, revealing new ways of viewing photoelectron diffraction data, and potentially new information about the surface structure being studied. In this article the authors report a brief summary of a structural study being done on the c(2x2) Mn/Ni(100) surface alloy. This system is interesting for both structural and magnetic reasons. Magnetically, the Mn/Ni(100) surface alloy exhibits parallel coupling of the Mn and Ni moments, which is opposite to the reported coupling for the bulk, disordered, alloy. Structurally, the Mn atoms are believed to lie well above the surface plane.

  17. Maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 knockout mice.

    PubMed

    Sclafani, Anthony; Ackroff, Karen

    2014-07-01

    Adenosine triphosphate is a critical neurotransmitter in the gustatory response to the 5 primary tastes in mice. Genetic deletion of the purinergic P2X2/P2X3 receptor greatly reduces the neural and behavioral response to prototypical primary taste stimuli. In this study, we examined the behavioral response of P2X double knockout mice to maltodextrin and fat stimuli, which appear to activate additional taste channels. P2X double knockout and wild-type mice were given 24-h choice tests (vs. water) with ascending concentrations of Polycose and Intralipid. In Experiment 1, naive double knockout mice, unlike wild-type mice, were indifferent to dilute (0.5-4%) Polycose solutions but preferred concentrated (8-32%) Polycose to water. In a retest, the Polycose-experienced double knockout mice, like wild-type mice, preferred all Polycose concentrations. In Experiment 2, naive double knockout mice, unlike wild-type mice, were indifferent to dilute (0.313-2.5%) Intralipid emulsions but preferred concentrated (5-20%) Intralipid to water. In a retest, the fat-experienced double knockout mice, like wild-type mice, strongly preferred 0.313-5% Intralipid to water. These results indicate that the inherent preferences of mice for maltodextrin and fat are dependent upon adenosine triphosphate taste cell signaling. With experience, however, P2X double knockout mice develop strong preferences for the nontaste flavor qualities of maltodextrin and fat conditioned by the postoral actions of these nutrients.

  18. Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells.

    PubMed

    Morton-Jones, Rachel T; Vlajkovic, Srdjan M; Thorne, Peter R; Cockayne, Debra A; Ryan, Allen F; Housley, Gary D

    2015-12-01

    In the cochlea, Reissner's membrane separates the scala media endolymphatic compartment that sustains the positive endocochlear potential and ion composition necessary for sound transduction, from the scala vestibuli perilymphatic compartment. It is known that with sustained elevated sound levels, adenosine 5'-triphosphate (ATP) is released into the endolymph and ATP-gated ion channels on the epithelial cells lining the endolymphatic compartment shunt the electrochemical driving force, contributing to protective purinergic hearing adaptation. This study characterises the properties of epithelial cell P2X(2)-type ATP-activated membrane conductance in the mouse Reissner's membrane, which forms a substantial fraction of the scale media surface. The cells were found to express two isoforms (a and b) of the P2X(2) subunit arising from alternative splicing of the messenger RNA (mRNA) transcript that could contribute to the trimeric subunit assembly. The ATP-activated conductance demonstrated both immediate and delayed desensitisation consistent with incorporation of the combination of P2X(2) subunit isoforms. Activation by the ATP analogue 2meSATP had equipotency to ATP, whereas α,β-meATP and adenosine 5'-diphosphate (ADP) were ineffective. Positive allosteric modulation of the P2X(2) channels by protons was profound. This native conductance was blocked by the P2X(2)-selective blocker pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) and the conductance was absent in these cells isolated from mice null for the P2rX2 gene encoding the P2X(2) receptor subunit. The activation and desensitisation properties of the Reissner's membrane epithelial cell ATP-gated P2X(2) channels likely contribute to the sensitivity and kinetics of purinergic control of the electrochemical driving force for sound transduction invoked by noise exposure.

  19. The Use of a Fractional Factorial Design to Determine the Factors That Impact 1,3-Propanediol Production from Glycerol by Halanaerobium hydrogeniformans.

    PubMed

    Kalia, Shivani; Trager, Jordan; Sitton, Oliver C; Mormile, Melanie R

    2016-01-01

    In recent years, biodiesel, a substitute for fossil fuels, has led to the excessive production of crude glycerol. The resulting crude glycerol can possess a high concentration of salts and an alkaline pH. Moreover, current crude glycerol purification methods are expensive, rendering this former commodity a waste product. However, Halanaerobium hydrogeniformans, a haloalkaliphilic bacterium, possesses the metabolic capability to convert glycerol into 1,3-propanediol, a valuable commodity compound, without the need for salt dilution or adjusting pH when grown on this waste. Experiments were performed with different combinations of 24 medium components to determine their impact on the production of 1,3-propanediol by using a fractional factorial design. Tested medium components were selected based on data from the organism's genome. Analysis of HPLC data revealed enhanced production of 1,3-propanediol with additional glycerol, pH, vitamin B12, ammonium ions, sodium sulfide, cysteine, iron, and cobalt. However, other selected components; nitrate ions, phosphate ions, sulfate ions, sodium:potassium ratio, chloride, calcium, magnesium, silicon, manganese, zinc, borate, nickel, molybdenum, tungstate, copper and aluminum, did not enhance 1,3-propanediol production. The use of a fractional factorial design enabled the quick and efficient assessment of the impact of 24 different medium components on 1,3-propanediol production from glycerol from a haloalkaliphilic bacterium. PMID:27556494

  20. The Use of a Fractional Factorial Design to Determine the Factors That Impact 1,3-Propanediol Production from Glycerol by Halanaerobium hydrogeniformans

    PubMed Central

    Kalia, Shivani; Trager, Jordan; Sitton, Oliver C.; Mormile, Melanie R.

    2016-01-01

    In recent years, biodiesel, a substitute for fossil fuels, has led to the excessive production of crude glycerol. The resulting crude glycerol can possess a high concentration of salts and an alkaline pH. Moreover, current crude glycerol purification methods are expensive, rendering this former commodity a waste product. However, Halanaerobium hydrogeniformans, a haloalkaliphilic bacterium, possesses the metabolic capability to convert glycerol into 1,3-propanediol, a valuable commodity compound, without the need for salt dilution or adjusting pH when grown on this waste. Experiments were performed with different combinations of 24 medium components to determine their impact on the production of 1,3-propanediol by using a fractional factorial design. Tested medium components were selected based on data from the organism’s genome. Analysis of HPLC data revealed enhanced production of 1,3-propanediol with additional glycerol, pH, vitamin B12, ammonium ions, sodium sulfide, cysteine, iron, and cobalt. However, other selected components; nitrate ions, phosphate ions, sulfate ions, sodium:potassium ratio, chloride, calcium, magnesium, silicon, manganese, zinc, borate, nickel, molybdenum, tungstate, copper and aluminum, did not enhance 1,3-propanediol production. The use of a fractional factorial design enabled the quick and efficient assessment of the impact of 24 different medium components on 1,3-propanediol production from glycerol from a haloalkaliphilic bacterium. PMID:27556494

  1. Study of Montmorillonite Clay for the Removal of Copper (II) by Adsorption: Full Factorial Design Approach and Cascade Forward Neural Network

    PubMed Central

    Turan, Nurdan Gamze; Ozgonenel, Okan

    2013-01-01

    An intensive study has been made of the removal efficiency of Cu(II) from industrial leachate by biosorption of montmorillonite. A 24 factorial design and cascade forward neural network (CFNN) were used to display the significant levels of the analyzed factors on the removal efficiency. The obtained model based on 24 factorial design was statistically tested using the well-known methods. The statistical analysis proves that the main effects of analyzed parameters were significant by an obtained linear model within a 95% confidence interval. The proposed CFNN model requires less experimental data and minimum calculations. Moreover, it is found to be cost-effective due to inherent advantages of its network structure. Optimization of the levels of the analyzed factors was achieved by minimizing adsorbent dosage and contact time, which were costly, and maximizing Cu(II) removal efficiency. The suggested optimum conditions are initial pH at 6, adsorbent dosage at 10 mg/L, and contact time at 10 min using raw montmorillonite with the Cu(II) removal of 80.7%. At the optimum values, removal efficiency was increased to 88.91% if the modified montmorillonite was used. PMID:24453833

  2. Deletion of P2X2 and P2X3 Receptor Subunits Does Not Alter Motility of the Mouse Colon

    PubMed Central

    DeVries, Matthew P.; Vessalo, Megan; Galligan, James J.

    2010-01-01

    Purinergic P2X receptors contribute to neurotransmission in the gut. P2X receptors are ligand-gated cation channels that mediate synaptic excitation in subsets of enteric neurons. The present study evaluated colonic motility in vitro and in vivo in wild type (WT) and P2X2 and P2X3 subunit knockout (KO) mice. The muscarinic receptor agonist, bethanechol (0.3–3 μM), caused similar contractions of the longitudinal muscle in colon segments from WT, P2X2 and P2X3 subunit KO mice. Nicotine (1–300 μM), acting at neuronal nicotinic receptors, caused similar longitudinal muscle relaxations in colonic segments from WT and P2X2 and P2X3 subunit KO mice. Nicotine-induced relaxations were inhibited by nitro-l-arginine (NLA, 100 μM) and apamin (0.1 μM) which block inhibitory neuromuscular transmission. ATP (1–1000 μM) caused contractions only in the presence of NLA and apamin. ATP-induced contractions were similar in colon segments from WT, P2X2 and P2X3 KO mice. The mouse colon generates spontaneous migrating motor complexes (MMCs) in vitro. The MMC frequency was higher in P2X2 KO compared to WT tissues; other parameters of the MMC were similar in colon segments from WT, P2X2 and P2X3 KO mice. 5-Hydroxytryptophan-induced fecal output was similar in WT, P2X2 and P2X3 KO mice. These data indicate that nicotinic receptors are located predominately on inhibitory motor neurons supplying the longitudinal muscle in the mouse colon. P2X2 or P2X3 subunit containing receptors are not localized to motor neurons supplying the longitudinal muscle. Synaptic transmission mediated by P2X2 or P2X3 subunit containing receptors is not required for propulsive motility in the mouse colon. PMID:20582262

  3. Self-organization in a simple model of adaptive agents playing 2 x 2 games with arbitrary payoff matrices.

    PubMed

    Fort, H; Viola, S

    2004-03-01

    We analyze, both analytically and numerically, the self-organization of a system of "selfish" adaptive agents playing an arbitrary iterated pairwise game (defined by a 2 x 2 payoff matrix). Examples of possible games to play are the prisoner's dilemma (PD) game, the chicken game, the hero game, etc. The agents have no memory, use strategies not based on direct reciprocity nor "tags" and are chosen at random, i.e., geographical vicinity is neglected. They can play two possible strategies: cooperate (C) or defect (D). The players measure their success by comparing their utilities with an estimate for the expected benefits and update their strategy following a simple rule. Two versions of the model are studied: (1) the deterministic version (the agents are either in definite states C or D) and (2) the stochastic version (the agents have a probability c of playing C). Using a general master equation we compute the equilibrium states into which the system self-organizes, characterized by their average probability of cooperation c(eq). Depending on the payoff matrix, we show that c(eq) can take five different values. We also consider the mixing of agents using two different payoff matrices and show that any value of c(eq) can be reached by tuning the proportions of agents using each payoff matrix. In particular, this can be used as a way to simulate the effect of a fraction d of "antisocial" individuals--incapable of realizing any value to cooperation--on the cooperative regime hold by a population of neutral or "normal" agents. PMID:15089364

  4. The rare-earth metal carbide halide superconductors RE 2C 2X 2 (RE=Y, La; X=Cl, Br, I)

    NASA Astrophysics Data System (ADS)

    Kremer, R. K.; Ahn, K.; Henn, R. W.; Mattausch, Hj; Schnelle, W.; Stolovits, A.; Simon, A.

    1999-05-01

    Superconductivity in layered yttrium carbide bromides and iodides with transition temperatures ranging up to 11.6 K is achieved by adjusting the Br:I, ratio to ≈1:3 in phases of Y 2C 2(Br,I) 2. In our contribution, we compile basic physical and chemical properties of Y 2C 2X 2 (X=Cl, Br, I) and present new results of the La-based phases La 2C 2X 2 (X=Br, I).

  5. Photoelectron spectroscopy of GaX2-, Ga2X-, Ga2X2-, and Ga2X3-(X=P,As)

    NASA Astrophysics Data System (ADS)

    Taylor, Travis R.; Gómez, Harry; Asmis, Knut R.; Neumark, Daniel M.

    2001-09-01

    Anion photoelectron spectra taken at various photodetachment wavelengths have been obtained for GaX2-, Ga2X-, Ga2X2-, and Ga2X3- (X=P,As). The incorporation of a liquid nitrogen cooled channel in the ion source resulted in substantial vibrational cooling of the cluster anions, resulting in resolved vibrational progressions in the photoelectron spectra of all species except Ga2X2-. Electron affinities, electronic term values, and vibrational frequencies are reported and compared to electronic structure calculations. In addition, similarities and differences between the phosphorus and arsenic-containing isovalent species are discussed.

  6. Factory Cost Model

    SciTech Connect

    Bomber, Tom

    1996-12-17

    The Factory Cost Model (FCM) is an economic analysis tool intended to provide flat panel display (FPD) and other similar discrete component manufacturers with the ability to make first-order estimates of the cost of unit production. This software has several intended uses. Primary among these is the ability to provide first-order economic analysis for future factories. Consequently, the model requires a minimal level of input detail, and accomodates situations where actual production data are not available. This software is designed to be activity based such that most of the calculated direct costs are associated with the steps of a manufacturibg process. The FCM architecture has the ability to accomodate the analysis of existing manufacturing facilities. The FCM can provide assistance with strategic economic decisions surrounding production related matters. For instance, the program can project the effect on costs and resources of a new product''s introduction, or it can assess the potential cost reduction produced by step yield improvements in the manufacturing process.

  7. Factory Cost Model

    1996-12-17

    The Factory Cost Model (FCM) is an economic analysis tool intended to provide flat panel display (FPD) and other similar discrete component manufacturers with the ability to make first-order estimates of the cost of unit production. This software has several intended uses. Primary among these is the ability to provide first-order economic analysis for future factories. Consequently, the model requires a minimal level of input detail, and accomodates situations where actual production data are notmore » available. This software is designed to be activity based such that most of the calculated direct costs are associated with the steps of a manufacturibg process. The FCM architecture has the ability to accomodate the analysis of existing manufacturing facilities. The FCM can provide assistance with strategic economic decisions surrounding production related matters. For instance, the program can project the effect on costs and resources of a new product''s introduction, or it can assess the potential cost reduction produced by step yield improvements in the manufacturing process.« less

  8. The Low Energy Neutrino Factory

    SciTech Connect

    Bross, Alan; Geer, Steve; Ellis, Malcolm; Fernandez Martinez, Enrique; Li, Tracey; Pascoli, Silvia; Mena, Olga

    2010-03-30

    We show that a low energy neutrino factory with a baseline of 1300 km and muon energy of 4.5 GeV has an excellent physics reach. The results of our optimisation studies demonstrate that such a setup can have remarkable sensitivity to theta{sub 13} and delta for sin{sup 2}(2theta{sub 13})>10{sup -4}, and to the mass hierarchy for sin{sup 2}(2theta{sub 13})>10{sup -3}. We also illustrate the power of the unique combination of golden and platinum channels accessible to the low energy neutrino factory. We have considered both a 20 kton totally active scintillating detector and a 100 kton liquid argon detector as possible detector technologies, finding that a liquid argon detector with very good background rejection can produce sensitivity to theta{sub 13} and delta with that of the International Design Study neutrino factory.

  9. Polymeric nanoparticles loaded with the 3,5,3′-triiodothyroacetic acid (Triac), a thyroid hormone: factorial design, characterization, and release kinetics

    PubMed Central

    dos Santos, Karen C; da Silva, Maria Fatima GF; Pereira-Filho, Edenir R; Fernandes, Joao B; Polikarpov, Igor; Forim, Moacir R

    2012-01-01

    This present investigation deals with the development and optimization of polymeric nanoparticle systems loaded with 3,5,3′-triiodothyroacetic acid (Triac). A 211–6 fractional factorial design and another 22 factorial design were used to study the contrasts on particle size distribution, morphology, surface charge, drug content, entrapment efficiency, and in vitro drug release profiles. The independent variables were the concentration of Triac, type and quantity of both polymer and oil, quantity of Span™ 60 and Tween® 80, volume of solvent and water, and velocity of both magnetic stirring and the transfer of the organic phase into the aqueous solution. The results of optimized formulations showed a narrow size distribution with a polydispersity index lower than 0.200. The particle sizes were on average 159.6 nm and 285.6 nm for nanospheres and nanocapsules, respectively. The zeta potential was higher than 20 mV (in module) and the entrapment efficiency was nearly 100%. A high-performance liquid chromatography method was developed, validated, and efficiently applied to Triac quantification in colloidal suspension. The main independent variables were the type and quantity of the polymer and oil. In vitro drug release profile depicted several features to sustain Triac release. Different formulations showed various release rates indicating an interaction between Triac and other formulation compounds such as polymer and/or oil quantity. Two different models were identified (biexponential and monoexponential) that allowed the control of both the release rate and Triac concentration. Thus, the prepared nanoparticles described here may be of clinical importance in delivering Triac for thyroid treatment. PMID:24198495

  10. Influence of the Formulation Parameters on the Particle Size and Encapsulation Efficiency of Resveratrol in PLA and PLA-PEG Blend Nanoparticles: A Factorial Design.

    PubMed

    Lindner, Gabriela da Rocha; Dalmolin, Luciana Facco; Khalil, Najeh Maissar; Mainardes, Rubiana Mara

    2015-12-01

    Polymeric nanoparticles are colloidal systems that promote protection and modification of physicochemical characteristics of a drug and that also ensure controlled and extended drug release. This paper reports a 2(3) factorial design study to optimize poly(lactide) (PLA) and poly(lactide)-polyethylene glycol (PLA-PEG) blend nanoparticles containing resveratrol (RVT) for prolonged release. The independent variables analyzed were solvent composition, surfactant concentration and ratio of aqueous to organic phase (two levels each factor). Mean particle size and RVT encapsulation efficiency were set as the dependent variables. The selected optimized parameters were set as organic phase comprised of a mixture of dichloromethane and ethyl acetate, 1% of surfactant polyvinyl alcohol and a 3:1 ratio of aqueous to organic phase, for both PLA and PLA-PEG blend nanoparticles. This formulation originated nanoparticles with size of 228 ± 10 nm and 185 ± 70 nm and RVT encapsulation efficiency of 82 ± 10% and 76 ± 7% for PLA and PLA-PEG blend nanoparticles, respectively. The in vitro release study showed a biphasic pattern with prolonged RVT release and PEG did not influence the RVT release. The in vitro release data were in favor of Higuchi-diffusion kinetics for both nanoformulations and the Kossmeyer-Peppas coefficient indicated that anomalous transport was the main release mechanism of RVT. PLA and PLA-PEG blend nanoparticles produced with single emulsion-solvent evaporation technology were found to be a promising approach for the incorporation of RVT and promoted its controlled release. The factorial design is a tool of great value in choosing formulations with optimized parameters.

  11. Factorial experimental design for the culture of human embryonic stem cells as aggregates in stirred suspension bioreactors reveals the potential for interaction effects between bioprocess parameters.

    PubMed

    Hunt, Megan M; Meng, Guoliang; Rancourt, Derrick E; Gates, Ian D; Kallos, Michael S

    2014-01-01

    Traditional optimization of culture parameters for the large-scale culture of human embryonic stem cells (ESCs) as aggregates is carried out in a stepwise manner whereby the effect of varying each culture parameter is investigated individually. However, as evidenced by the wide range of published protocols and culture performance indicators (growth rates, pluripotency marker expression, etc.), there is a lack of systematic investigation into the true effect of varying culture parameters especially with respect to potential interactions between culture variables. Here we describe the design and execution of a two-parameter, three-level (3(2)) factorial experiment resulting in nine conditions that were run in duplicate 125-mL stirred suspension bioreactors. The two parameters investigated here were inoculation density and agitation rate, which are easily controlled, but currently, poorly characterized. Cell readouts analyzed included fold expansion, maximum density, and exponential growth rate. Our results reveal that the choice of best case culture parameters was dependent on which cell property was chosen as the primary output variable. Subsequent statistical analyses via two-way analysis of variance indicated significant interaction effects between inoculation density and agitation rate specifically in the case of exponential growth rates. Results indicate that stepwise optimization has the potential to miss out on the true optimal case. In addition, choosing an optimum condition for a culture output of interest from the factorial design yielded similar results when repeated with the same cell line indicating reproducibility. We finally validated that human ESCs remain pluripotent in suspension culture as aggregates under our optimal conditions and maintain their differentiation capabilities as well as a stable karyotype and strong expression levels of specific human ESC markers over several passages in suspension bioreactors.

  12. X1X1X2X2/X1X2Y sex chromosome systems in the Neotropical Gymnotiformes electric fish of the genus Brachyhypopomus.

    PubMed

    Cardoso, Adauto Lima; Pieczarka, Julio Cesar; Nagamachi, Cleusa Yoshiko

    2015-05-01

    Several types of sex chromosome systems have been recorded among Gymnotiformes, including male and female heterogamety, simple and multiple sex chromosomes, and different mechanisms of origin and evolution. The X1X1X2X2/X1X2Y systems identified in three species of this order are considered homoplasic for the group. In the genus Brachyhypopomus, only B. gauderio presented this type of system. Herein we describe the karyotypes of Brachyhypopomus pinnicaudatus and B. n. sp. FLAV, which have an X1X1X2X2/X1X2Y sex chromosome system that evolved via fusion between an autosome and the Y chromosome. The morphology of the chromosomes and the meiotic pairing suggest that the sex chromosomes of B. gauderio and B. pinnicaudatus have a common origin, whereas in B . n. sp. FLAV the sex chromosome system evolved independently. However, we cannot discard the possibility of common origin followed by distinct processes of differentiation. The identification of two new karyotypes with an X1X1X2X2/X1X2Y sex chromosome system in Gymnotiformes makes it the most common among the karyotyped species of the group. Comparisons of these karyotypes and the evolutionary history of the taxa indicate independent origins for their sex chromosomes systems. The recurrent emergence of the X1X1X2X2/X1X2Y system may represent sex chromosomes turnover events in Gymnotiformes. PMID:26273225

  13. Sport Ability Beliefs, 2 x 2 Achievement Goals, and Intrinsic Motivation: The Moderating Role of Perceived Competence in Sport and Exercise

    ERIC Educational Resources Information Center

    Wang, C. K. John; Liu, Woon Chia; Lochbaum, Marc R.; Stevenson, Sarah J.

    2009-01-01

    We examined whether perceived competence moderated the relationships between implicit theories, 2 x 2 achievement goals, and intrinsic motivation for sports and physical activity. We placed 309 university students into high and moderate perceived competence groups. When perceived competence was high, entity beliefs did not predict the…

  14. Charged Particle Optics in Circular Higgs Factory

    SciTech Connect

    Cai, Yunhai

    2015-02-26

    Similar to a super B-factory, a circular Higgs factory will require strong focusing systems near the interaction points and a low-emittance lattice in arcs to achieve a factory luminosity. At electron beam energy of 120 GeV, beamstrahlung effects during the collision pose an additional challenge to the collider design. In particular, a large momentum acceptance at 2 percent level is necessary to retain an adequate beam lifetime. This turns out to be the most challenging aspect in the design of circular Higgs factory. In this paper, an example will be provided to illustrate the beam dynamics in circular Higgs factory, emphasizing on the chromatic optics. Basic optical modules and advanced analysis will be presented. Most important, we will show that 2% momentum aperture is achievable

  15. Optimization of parameters for the quantitative surface-enhanced Raman scattering detection of mephedrone using a fractional factorial design and a portable Raman spectrometer.

    PubMed

    Mabbott, Samuel; Correa, Elon; Cowcher, David P; Allwood, J William; Goodacre, Royston

    2013-01-15

    A new optimization strategy for the SERS detection of mephedrone using a portable Raman system has been developed. A fractional factorial design was employed, and the number of statistically significant experiments (288) was greatly reduced from the actual total number of experiments (1722), which minimized the workload while maintaining the statistical integrity of the results. A number of conditions were explored in relation to mephedrone SERS signal optimization including the type of nanoparticle, pH, and aggregating agents (salts). Through exercising this design, it was possible to derive the significance of each of the individual variables, and we discovered four optimized SERS protocols for which the reproducibility of the SERS signal and the limit of detection (LOD) of mephedrone were established. Using traditional nanoparticles with a combination of salts and pHs, it was shown that the relative standard deviations of mephedrone-specific Raman peaks were as low as 0.51%, and the LOD was estimated to be around 1.6 μg/mL (9.06 × 10(-6) M), a detection limit well beyond the scope of conventional Raman and extremely low for an analytical method optimized for quick and uncomplicated in-field use.

  16. Determination of nickel in food samples by flame atomic absorption spectroscopy after preconcentration and microextraction based ionic liquids using full factorial and central composite design.

    PubMed

    Zarei, Zohre; Shemirani, Farzaneh

    2012-12-01

    In this research, a microextraction technique based on ionic liquids (ILs) termed in situ solvent formation microextraction (ISFME) was used for determination of nickel in solutions. 1-(2-pyridylazo)-2-naphtol (PAN) was chosen as a complexing agent. After preconcentration, the settled IL-phase was dissolved in 50 μL of ethanol and aspirated into the flame atomic absorption spectrometer (FAAS) using a home-made microsample introduction system. Injection of 50 μL volumes of analyte into an air-acetylene flame provided very sensitive spike-like and reproducible signals. ISFME is based on phase separation phenomenon of ionic liquids in aqueous solutions. This method is simple and rapid for extraction and preconcentration of metal ions from food samples and can be applied for the sample solutions containing very high concentrations of salt. Furthermore, this technique is much safer in comparison with the organic solvent extraction because of using ionic liquid. The effective parameters such as amount of IL, salt effect, concentration of the chelating agent and ion pairing agent were inspected by a full factorial design to identify important parameters and their interactions. Next, a central composite design was applied to obtain optimum point of the important parameters. Under the optimum conditions, the calibration graph was linear over the range of 2 to 80 ng/mL. The limit of detection and relative standard deviation (n= 6) were 0.6 ng/mL and 2%, respectively.

  17. Determination of nickel in food samples by flame atomic absorption spectroscopy after preconcentration and microextraction based ionic liquids using full factorial and central composite design.

    PubMed

    Zarei, Zohre; Shemirani, Farzaneh

    2012-12-01

    In this research, a microextraction technique based on ionic liquids (ILs) termed in situ solvent formation microextraction (ISFME) was used for determination of nickel in solutions. 1-(2-pyridylazo)-2-naphtol (PAN) was chosen as a complexing agent. After preconcentration, the settled IL-phase was dissolved in 50 μL of ethanol and aspirated into the flame atomic absorption spectrometer (FAAS) using a home-made microsample introduction system. Injection of 50 μL volumes of analyte into an air-acetylene flame provided very sensitive spike-like and reproducible signals. ISFME is based on phase separation phenomenon of ionic liquids in aqueous solutions. This method is simple and rapid for extraction and preconcentration of metal ions from food samples and can be applied for the sample solutions containing very high concentrations of salt. Furthermore, this technique is much safer in comparison with the organic solvent extraction because of using ionic liquid. The effective parameters such as amount of IL, salt effect, concentration of the chelating agent and ion pairing agent were inspected by a full factorial design to identify important parameters and their interactions. Next, a central composite design was applied to obtain optimum point of the important parameters. Under the optimum conditions, the calibration graph was linear over the range of 2 to 80 ng/mL. The limit of detection and relative standard deviation (n= 6) were 0.6 ng/mL and 2%, respectively. PMID:22853633

  18. Factorially designed crystallization trials of the full-length P0 myelin membrane glycoprotein. I. Precipitation diagram

    NASA Astrophysics Data System (ADS)

    Sedzik, Jan; Kotake, Yoshiko; Uyemura, Keiichi; Ataka, Mitsuo

    2003-01-01

    P0 glycoprotein is the abundant membrane protein of myelin of the peripheral nervous system. We report now the statistical design of the crystallization experiments; based on our belief that important information regarding supersaturation of protein or its solubility nature, as well as metastable state, nucleation or precipitation, are hidden in the trials in which no crystals grow. It is possible to work out this information when the whole set of experiments is designed in such a way as to allow statistical analyses. We selected seven factors, which we believe to be important for crystallization: protein concentration, pH of buffer, nature of precipitant, concentration of precipitant, nature of detergent, additives and temperature. The experimental matrix and detailed work sheet to make 148 solutions having random but balanced combination of these levels were calculated using the program DESIGN. A visual evaluation of crystallization drops was performed using light microscopy. We were able to plot the precipitation boundary diagram. Based on this diagram we have eliminated factors (and levels) that were driving the protein into precipitation. It is known that the precipitation boundary is related to the solubility curves for protein crystals, in the neighborhood of which nucleation and further crystallization is most likely to occur. These conditions are currently being refined to identify important factors (or its levels) that can be crucial in obtaining large and well diffracting crystals. Full-length P0 protein has never been crystallized for structural determination.

  19. Vatalanib decrease the positive interaction of VEGF receptor-2 and P2X2/3 receptor in chronic constriction injury rats.

    PubMed

    Liu, Shuangmei; Xu, Changshui; Li, Guilin; Liu, Han; Xie, Jinyan; Tu, Guihua; Peng, Haiying; Qiu, Shuyi; Liang, Shangdong

    2012-05-01

    Neuropathic pain can arise from a lesion affecting the peripheral nervous system. Selective P2X(3) and P2X(2/3) receptors' antagonists effectively reduce neuropathic pain. VEGF inhibitors are effective for pain relief. The present study investigated the effects of Vatalanib (VEGF receptor-2 (VEGFR-2) inhibitor) on the neuropathic pain to address the interaction of VEGFR-2 and P2X(2/3) receptor in dorsal root ganglia of chronic constriction injury (CCI) rats. Neuropathic pain symptoms following CCI are similar to most peripheral lesions as assessed by the Neuropathic Pain Symptom Inventory. Sprague-Dawley rats were randomly divided into sham group, CCI group and CCI rats treated with Vatalanib group. Mechanical withdrawal threshold and thermal withdrawal latency were measured. Co-expression of VEGFR-2 and P2X(2) or P2X(3) in L4-6 dorsal root ganglia (DRG) was detected by double-label immunofluorescence. The modulation effect of VEGF on P2X(2/3) receptor agonist-activated currents in freshly isolated DRG neurons of rats both of sham and CCI rats was recorded by whole-cell patch-clamp technique. The mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) in CCI group were lower than those in sham group (p<0.05). MWT and TWL in CCI rats treated with Vatalanib group were increased compared with those in CCI group (p<0.05). VEGFR-2 and P2X(2) or P2X(3) receptors were co-expressed in the cytoplasm and surface membranes of DRG. The co-expression of VEGFR-2 and P2X(2) or P2X(3) receptor in CCI group exhibited more intense staining than those in sham group and CCI rats treated with Vatalanib group, respectively. VEGF enhanced the amplitude of ATP and α,β-meATP -activated currents of both sham and CCI rats. Increment effects of VEGF on ATP and α,β-meATP -activated currents in CCI rats were higher than those in sham rats. Both ATP (100 μM) and α,β-meATP (10 μM)- activated currents enhanced by VEGF ( 1nM) were significantly blocked by Vatalanib (1

  20. Factorial design optimization and characterization of poly-lactic acid (PLA) nanoparticle formation for the delivery of grape extracts.

    PubMed

    Fernández, Katherina; Aburto, Javiera; von Plessing, Carlos; Rockel, Marlene; Aspé, Estrella

    2016-09-15

    Proanthocyanidins (PAs) extracted from grapes have several bioactive properties, giving them potential medical uses. However, PAs are unstable in the digestive tract and must be stabilized to allow oral administration, which can be accomplished by nanoencapsulation. In this study, PAs extracted from grape seed and skin were stabilized with poly-d,l-lactide (PLA) polymer by the emulsion-evaporation method. An experimental Box-Behnken design was implemented, evaluating the influence of three factors: sonication time (30-360s) for the emulsion formation, loading of grape extracts (5-20%) and concentration of stabilizing agent (polyvinyl alcohol, PVA: 1-3%). The process was optimized to achieve higher encapsulation efficiency (EE=82.7%) and a smaller size (256 nm). The nanoparticles (NPs) were physically analyzed by TEM, FT-IR, TGA and DTG to characterize the nanoencapsulation process. In vitro release studies, through stomach and intestinal simulation, showed a sustained release of PAs from PLA-NPs. PMID:27080882

  1. Optimization of headspace solid-phase microextraction for the analysis of specific flavors in enzyme modified and natural Cheddar cheese using factorial design and response surface methodology.

    PubMed

    Januszkiewicz, Julien; Sabik, Hassan; Azarnia, Sorayya; Lee, Byong

    2008-06-27

    A headspace solid-phase microextraction (HS-SPME) combined with gas chromatography-mass spectrometry (GC/MS) method was developed using experimental designs to quantify the flavor of commercial Cheddar cheese and enzyme-modified Cheddar cheese (EMCC). Seven target compounds (dimethyl disulfide, hexanal, hexanol, 2-heptanone, ethyl hexanoate, heptanoic acid, delta-decalactone) representative of different chemical families frequently present in Cheddar cheese were selected for this study. Three types of SPME fibres were tested: Carboxen/polydimethylsiloxane (CAR/PDMS), polyacrylate (PA) and Carbowax/divinylbenzene (CW/DVB). NaCl concentration and temperature, as well as extraction time were tested for their effect on the HS-SPME process. Two series of two-level full factorial designs were carried out for each fibre to determine the factors which best support the extraction of target flavors. Therefore, central composite designs (CCDs) were performed and response surface models were derived. Optimal extraction conditions for all selected compounds, including internal standards, were: 50 min at 55 degrees C in 3M NaCl for CAR/PDMS, 64 min at 62 degrees C in 6M NaCl for PA, and 37 min at 67 degrees C in 6M NaCl for CW/DVB. Given its superior sensitivity, CAR/PDMS fibre was selected to evaluate the target analytes in commercial Cheddar cheese and EMCC. With this fibre, calibration curves were linear for all targeted compounds (from 0.5 to 6 microg g(-1)), except for heptanoic acid which only showed a linear response with PA fibres. Detection limits ranged from 0.3 to 1.6 microg g(-1) and quantification limits from 0.8 to 3.6 microg g(-1). The mean repeatability value for all flavor compounds was 8.8%. The method accuracy is satisfactory with recoveries ranging from 97 to 109%. Six of the targeted flavors were detected in commercial Cheddar cheese and EMCC. PMID:18495140

  2. Use of factorial design and Doehlert matrix for multivariate optimisation of an on-line preconcentration system for lead determination by flame atomic absorption spectrometry.

    PubMed

    Ferreira, S L C; dos Santos, W N L; Bezerra, M A; Lemos, V A; Bosque-Sendra, J M

    2003-02-01

    A system for on-line preconcentration and determination of lead by flame atomic absorption spectrometry (FAAS) was proposed. It was based on the sorption of lead(II) ions on a minicolumn of polyurethane foam loaded with 2-(2-thiazolylazo)-5-dimethylaminophenol (TAM). The optimisation step was carried out using two-level full factorial and Doehlert designs for the determination of the optimum conditions for lead preconcentration. The proposed procedure allowed the determination of lead with a detection limit of 2.2 microg L(-1), and a precision, calculated as relative standard deviation (RSD), of 2.4 and 6.8 for a lead concentration of 50.0 and 10.0 microg L(-1), respectively. A preconcentration factor of 45 and a sampling frequency of 27 samples per hour were obtained. The recovery achieved for lead determination in the presence of several cations demonstrated that this procedure has enough selectivity for analysis of environmental samples. The validation was carried out by analysis of certified reference material. This procedure was applied to lead determination in natural food. PMID:12589511

  3. Effect of process variables on the sulfate reduction process in bioreactors treating metal-containing wastewaters: factorial design and response surface analyses.

    PubMed

    Villa-Gomez, D K; Pakshirajan, K; Maestro, R; Mushi, S; Lens, P N L

    2015-07-01

    The individual and combined effect of the pH, chemical oxygen demand (COD) and SO4 (2-) concentration, metal to sulfide (M/S(2-)) ratio and hydraulic retention time (HRT) on the biological sulfate reduction (SR) process was evaluated in an inverse fluidized bed reactor by factorial design analysis (FDA) and response surface analysis (RSA). The regression-based model of the FDA described the experimental results well and revealed that the most significant variable affecting the process was the pH. The combined effect of the pH and HRT was barely observable, while the pH and COD concentration positive effect (up to 7 and 3 gCOD/L, respectively) enhanced the SR process. Contrary, the individual COD concentration effect only enhanced the COD removal efficiency, suggesting changes in the microbial pathway. The RSA showed that the M/S(2-) ratio determined whether the inhibition mechanism to the SR process was due to the presence of free metals or precipitated metal sulfides.

  4. Preparation, optimization and characterization of bovine lactoferrin-loaded liposomes and solid lipid particles modified by hydrophilic polymers using factorial design.

    PubMed

    Yao, Xudong; Bunt, Craig; Cornish, Jillian; Quek, Siew-Young; Wen, Jingyuan

    2014-05-01

    Bioadhesive liposomes and solid lipid particles (SLPs) modified by pectin and chitosan for oral administration of bovine lactoferrin (bLf) were prepared using a 2(4) full-factorial design to identify the key formulation variables influencing particle size and drug entrapment efficiency (EE). Netlike structures of the polymer-particle mixture consisting of a polymeric network in which multiple particles were imbedded were observed by scanning electron microscopy (SEM). Chemical stability of bLf after encapsulation into pectin- and chitosan-modified liposomes and SLPs was confirmed by Fourier transform infrared spectra (FTIR). Bovine lactoferrin was located within phospholipid bilayer, whereas in SLPs bLf was within the matrix. The crystalline nature of bLf after encapsulation was investigated by differential scanning calorimetry (DSC) of drug-loaded particles, indicating amorphous dispersion of bLf in the polymer-lipid matrix of pectin- and chitosan-modified liposomes and SLPs. In vivo pharmacokinetic investigation of bLf in pectin- and chitosan-modified liposomes and SLPs showed prolonged mean residence time (MRT) of bLf in rat blood and increased the relative bioavailability (Fbio %) by 1.95- to 2.69-fold compared with free bLf. The developed carrier systems are considered to be promising vehicles for oral delivery. PMID:24325576

  5. Novel lectin-modified poly(ethylene-co-vinyl acetate) mucoadhesive nanoparticles of carvedilol: preparation and in vitro optimization using a two-level factorial design.

    PubMed

    Varshosaz, Jaleh; Moazen, Ellaheh

    2014-08-01

    Carvedilol used in cardiovascular diseases has systemic bioavailability of 25-35%. The objective of this study was production of lectin-modified poly(ethylene-co-vinyl acetate) (PEVA) as mucoadhesive nanoparticles to enhance low oral bioavailability of carvedilol. Nanoparticles were prepared by the emulsification-solvent evaporation method using a two-level factorial design. The studied variables included the vinyl acetate content of the polymer, drug and polymer content. Surface modification of PEVA nanoparticles with lectin was carried out by the adsorption method and coupling efficiency was determined using the Bradford assay. Mucoadhesion of nanoparticles was studied on mucin. The particle size, polydispersity index, zeta potential, drug loading and drug release from nanoparticles were studied. The morphology of nanoparticles and crystalline status of the entrapped drug were studied by SEM, DSC and XRD tests, respectively. Results showed the most effective factor on particle size and zeta potential was the interaction of polymer and drug content while, drug loading efficiency and mucoadhesion were more affected by the interaction of polymer type and drug content. Drug concentration was the most effective variable on the drug release rate. The drug was in amorphous state in nanoparticles. The optimum nanoparticles obtained by 45 mg of copolymer contained 12% vinyl acetate/4.3 ml of organic phase and drug concentration of 37.5 wt% of polymer.

  6. Quantitative and qualitative optimization of allergen extraction from peanut and selected tree nuts. Part 2. Optimization of buffer and ionic strength using a full factorial experimental design.

    PubMed

    L'Hocine, Lamia; Pitre, Mélanie

    2016-03-01

    A full factorial design was used to assess the single and interactive effects of three non-denaturing aqueous (phosphate, borate, and carbonate) buffers at various ionic strengths (I) on allergen extractability from and immunoglobulin E (IgE) immunoreactivity of peanut, almond, hazelnut, and pistachio. The results indicated that the type and ionic strength of the buffer had different effects on protein recovery from the nuts under study. Substantial differences in protein profiles, abundance, and IgE-binding intensity with different combinations of pH and ionic strength were found. A significant interaction between pH and ionic strength was observed for pistachio and almond. The optimal buffer system conditions, which maximized the IgE-binding efficiency of allergens and provided satisfactory to superior protein recovery yield and profiles, were carbonate buffer at an ionic strength of I=0.075 for peanut, carbonate buffer at I=0.15 for almond, phosphate buffer at I=0.5 for hazelnut, and borate at I=0.15 for pistachio. The buffer type and its ionic strength could be manipulated to achieve the selective solubility of desired allergens.

  7. Quantitative and qualitative optimization of allergen extraction from peanut and selected tree nuts. Part 2. Optimization of buffer and ionic strength using a full factorial experimental design.

    PubMed

    L'Hocine, Lamia; Pitre, Mélanie

    2016-03-01

    A full factorial design was used to assess the single and interactive effects of three non-denaturing aqueous (phosphate, borate, and carbonate) buffers at various ionic strengths (I) on allergen extractability from and immunoglobulin E (IgE) immunoreactivity of peanut, almond, hazelnut, and pistachio. The results indicated that the type and ionic strength of the buffer had different effects on protein recovery from the nuts under study. Substantial differences in protein profiles, abundance, and IgE-binding intensity with different combinations of pH and ionic strength were found. A significant interaction between pH and ionic strength was observed for pistachio and almond. The optimal buffer system conditions, which maximized the IgE-binding efficiency of allergens and provided satisfactory to superior protein recovery yield and profiles, were carbonate buffer at an ionic strength of I=0.075 for peanut, carbonate buffer at I=0.15 for almond, phosphate buffer at I=0.5 for hazelnut, and borate at I=0.15 for pistachio. The buffer type and its ionic strength could be manipulated to achieve the selective solubility of desired allergens. PMID:26471623

  8. Formulation and optimization of coated PLGA – Zidovudine nanoparticles using factorial design and in vitro in vivo evaluations to determine brain targeting efficiency

    PubMed Central

    Peter Christoper, G.V.; Vijaya Raghavan, C.; Siddharth, K.; Siva Selva Kumar, M.; Hari Prasad, R.

    2013-01-01

    In the current study zidovudine loaded PLGA nanoparticles were prepared, coated and further investigated for its effectiveness in brain targeting. IR and DSC studies were performed to determine the interaction between excipients used and to find out the nature of drug in the formulation. Formulations were prepared by adopting 23 factorial designs to evaluate the effects of process and formulation variables. The prepared formulations were subjected for in vitro and in vivo evaluations. In vitro evaluations showed particle size below 100 nm, entrapment efficiency of formulations ranges of 28–57%, process yield of 60–76% was achieved and drug release for the formulations were in the range of 50–85%. The drug release from the formulations was found to follow Higuchi release pattern, n–value obtained after Korsemeyer plot was in the range of 0.56–0.78. In vivo evaluations were performed in mice after intraperitoneal administration of zidovudine drug solution, uncoated and coated formulation. Formulation when coated with Tween 80 achieved a higher concentration in the brain than that of the drug in solution and of the uncoated formulation. Stability studies indicated that there was no degradation of the drug in the formulation after 90 days of preparation when stored in refrigerated condition. PMID:24648825

  9. Factorial design analysis of the effects of wave function modifications on calculated HC and CC stretching frequencies in H 2C dbnd CHX and HC tbnd CX

    NASA Astrophysics Data System (ADS)

    Ramos, Mozart N.; Lopes, Kelson C.; Rusu, Victor H.; Araújo, Regiane C. M. U.

    2009-04-01

    Two-level factorial designs (FD) have been used to determine the effects of wave function modifications on calculated CH and CC harmonic stretching frequencies of the H 2C dbnd CHX and HC tbnd CX molecules with X = H, CH 3, F, Cl and CN. These modifications were treated at two levels, which consists in: (I) using either a double- or a triple-zeta valence basis set; (II) including or not diffuse functions in basis set, (III) including or not polarization functions in basis set, and (IV) performing a calculation with or without electron correlation beyond the Hartree-Fock level, i.e., MP2 or B3LYP. Our results have shown that valence (Val), diffuse (Dif), polarization (Pol) and electron correlation (Corr) main effects as well as the Pol/Corr second-order interaction effect are significant to build factorial models for these vibrational modes. When valence and diffuse functions are introduced in the basis set, the calculated HC and CC stretching frequencies are decreased in both the HC tbnd CX and H 2C dbnd CHX molecules. As expected, by far the correlation principal effect is the most important on the frequency values. This effect provokes a decrease of -281.4 cm -1 and -153.3 cm -1 in the C tbnd C and C dbnd C vibrational frequencies, respectively, using the MP2 calculations, whereas this decrease for the H sbnd C oscillator is -156.1 cm -1 and -116.1 cm -1 in HC tbnd CX and H 2C dbnd CHX, respectively. This same effect produces an important Pol/Corr interaction effect on HC and CC stretching frequencies, increasing their values by +45.3 cm -1 and +18.4 cm -1 in HC tbnd CX, respectively, whereas their corresponding values in H 2C dbnd CHX are +43.9 cm -1 and +11.0 cm -1, respectively. Finally, algebraic models were then established to explain how calculated HC and CC stretching frequencies in HC tbnd CX and H 2C dbnd CHX depend on the characteristics of the molecular orbital wave functions.

  10. Evaluation and simultaneous optimization of bio-hydrogen production using 3 2 factorial design and the desirability function

    NASA Astrophysics Data System (ADS)

    Cuetos, M. J.; Gómez, X.; Escapa, A.; Morán, A.

    Various mixtures incorporating a simulated organic fraction of municipal solid wastes and blood from a poultry slaughterhouse were used as substrate in a dark fermentation process for the production of hydrogen. The individual and interactive effects of hydraulic retention time (HRT), solid content in the feed (%TS) and proportion of residues (%Blood) on bio-hydrogen production were studied in this work. A central composite design and response surface methodology were employed to determine the optimum conditions for the hydrogen production process. Experimental results were approximated to a second-order model with the principal effects of the three factors considered being statistically significant (P < 0.05). The production of hydrogen obtained from the experimental point at conditions close to best operability was 0.97 L Lr -1 day -1. Moreover, a desirability function was employed in order to optimize the process when a second, methanogenic, phase is coupled with it. In this last case, the optimum conditions lead to a reduction in the production of hydrogen when the optimization process involves the maximization of intermediary products.

  11. Photon collider Higgs factories

    NASA Astrophysics Data System (ADS)

    Telnov, V. I.

    2014-09-01

    The discovery of the Higgs boson (and still nothing else) have triggered appearance of many proposals of Higgs factories for precision measurement of the Higgs properties. Among them there are several projects of photon colliders (PC) without e+e- in addition to PLC based on e+e- linear colliders ILC and CLIC. In this paper, following a brief discussion of Higgs factories physics program I give an overview of photon colliders based on linear colliders ILC and CLIC, and of the recently proposed photon-collider Higgs factories with no e+e- collision option based on recirculation linacs in ring tunnels.

  12. Systems factorial technology with R.

    PubMed

    Houpt, Joseph W; Blaha, Leslie M; McIntire, John P; Havig, Paul R; Townsend, James T

    2014-06-01

    Systems factorial technology (SFT) comprises a set of powerful nonparametric models and measures, together with a theory-driven experiment methodology termed the double factorial paradigm (DFP), for assessing the cognitive information-processing mechanisms supporting the processing of multiple sources of information in a given task (Townsend and Nozawa, Journal of Mathematical Psychology 39:321-360, 1995). We provide an overview of the model-based measures of SFT, together with a tutorial on designing a DFP experiment to take advantage of all SFT measures in a single experiment. Illustrative examples are given to highlight the breadth of applicability of these techniques across psychology. We further introduce and demonstrate a new package for performing SFT analyses using R for statistical computing.

  13. Intelligent Robots for Factory Automation

    NASA Astrophysics Data System (ADS)

    Hall, E. L.; Oh, S. J.

    1985-04-01

    Industrial robots are now proven technology in a variety of applications including welding, materials handling, spray painting, machine loading and assembly. However, to fully realize the potential of these universal manipulators , "intelligence" needs to be added to the industrial robot. This involves adding sensory capability and machine intelligence to the controls. The "intelligence" may be added externally or as integral components of the robot. These new "intelligent robots" promise to greatly enhance the versatility of the robot for factory applications. The purpose of this paper is to present a brief review of the techniques and applications of intelligent robots for factory automation and to suggest possible designs for the intelligent robot of the future.

  14. The nearby supernova factory

    SciTech Connect

    Wood-Vasey, W.M.; Aldering, G.; Lee, B.C.; Loken, S.; Nugent, P.; Perlmutter, S.; Siegrist, J.; Wang, L.; Antilogus, P.; Astier, P.; Hardin, D.; Pain, R.; Copin, Y.; Smadja, G.; Gangler, E.; Castera, A.; Adam, G.; Bacon, R.; Lemonnier, J.-P.; Pecontal, A.; Pecontal, E.; Kessler, R.

    2004-01-23

    The Nearby Supernova Factory (SNfactory) is an ambitious project to find and study in detail approximately 300 nearby Type Ia supernovae (SNe Ia) at redshifts 0.03 < z < 0.08. This program will provide an exceptional data set of well-studied SNe in the nearby smooth Hubble flow that can be used as calibration for the current and future programs designed to use SNe to measure the cosmological parameters. The first key ingredient for this program is a reliable supply of Hubble-flow SNe systematically discovered in unprecedented numbers using the same techniques as those used in distant SNe searches. In 2002, 35 SNe were found using our test-bed pipeline for automated SN search and discovery. The pipeline uses images from the asteroid search conducted by the Near Earth Asteroid Tracking group at JPL. Improvements in our subtraction techniques and analysis have allowed us to increase our effective SN discovery rate to {approx}12 SNe/month in 2003.

  15. Manning the Unmanned Factory.

    ERIC Educational Resources Information Center

    Ebel, Karl-H.

    1989-01-01

    Suggests that total factory integration through computer networks, even when technically feasible, might be unwieldy, inefficient, and uneconomical because the human factor and accumulated know-how of the work force tend to be overlooked. (Author/JOW)

  16. Neutrino factories: realization and physics potential

    SciTech Connect

    Geer, S.; Zisman, M.S.; /LBL, Berkeley

    2006-12-01

    Neutrino Factories offer an exciting option for the long-term neutrino physics program. This new type of neutrino facility will provide beams with unique properties. Low systematic uncertainties at a Neutrino Factory, together with a unique and precisely known neutrino flavor content, will enable neutrino oscillation measurements to be made with unprecedented sensitivity and precision. Over recent years, the resulting neutrino factory physics potential has been discussed extensively in the literature. In addition, over the last six years the R&D necessary to realize a Neutrino Factory has been progressing, and has developed into a significant international activity. It is expected that, within about five more years, the initial phase of this R&D program will be complete and, if the community chooses to build this new type of neutrino source within the following decade, neutrino factory technology will be ready for the final R&D phase prior to construction. In this paper (1) an overview is given of the technical ingredients needed for a Neutrino Factory, (2) beam properties are described, (3) the resulting neutrino oscillation physics potential is summarized, (4) a more detailed description is given for one representative Neutrino Factory design, and (5) the ongoing R&D program is summarized, and future plans briefly described.

  17. MUON STORAGE RINGS - NEUTRINO FACTORIES

    SciTech Connect

    PARSA,Z.

    2000-05-30

    The concept of a muon storage ring based Neutrino Source (Neutrino Factory) has sparked considerable interest in the High Energy Physics community. Besides providing a first phase of a muon collider facility, it would generate more intense and well collimated neutrino beams than currently available. The BNL-AGS or some other proton driver would provide an intense proton beam that hits a target, produces pions that decay into muons. The muons must be cooled, accelerated and injected into a storage ring with a long straight section where they decay. The decays occurring in the straight sections of the ring would generate neutrino beams that could be directed to detectors located thousands of kilometers away, allowing studies of neutrino oscillations with precisions not currently accessible. For example, with the neutrino source at BNL, detectors at Soudan, Minnesota (1,715 km), and Gran Sasso, Italy (6,527 km) become very interesting possibilities. The feasibility of constructing and operating such a muon-storage-ring based Neutrino-Factory, including geotechnical questions related to building non-planar storage rings (e.g. at 8{degree} angle for BNL-Soudan, and 3{degree} angle for BNL-Gran Sasso) along with the design of the muon capture, cooling, acceleration, and storage ring for such a facility is being explored by the growing Neutrino Factory and Muon Collider Collaboration (NFMCC). The authors present overview of Neutrino Factory concept based on a muon storage ring, its components, physics opportunities, possible upgrade to a full muon collider, latest simulations of front-end, and a new bowtie-muon storage ring design.

  18. Perturbation Analysis of the (0,0) Band of the A2Π3/2 - X2Σ+ Transition in ZrN

    NASA Astrophysics Data System (ADS)

    Womack, Kaitlin A.; Dahms, Taylor; O'Brien, Leah C.; O'Brien, James J.

    2014-06-01

    The (0,0) band of the A2Π3/2 - X2Σ+ transition of ZrN is known to be perturbed. Both homogeneous and heterogeneous perturbations are observed in the spectrum. A recent high-level ab initio calculation has helped to identify several possible perturbing states. PGOPHER is used to analyze the interactions. ZrN was produced in a hollow cathode sputter source, and the spectrum was recorded in emission by a high resolution FT spectrometer. Results of the analysis will be presented.

  19. Adsorption of water on O(2x2)/Ru(0001): thermal stability and inhibition of dissociation by H2O-O bonding

    SciTech Connect

    Mugarza, Aitor; Shimizu, Tomoko; Cabrera-Sanfelix, Pepa; Sanchez-Portal, Daniel; Arnau, Andres; Salmeron, Miquel

    2008-08-01

    The effect of preadsorbed oxygen on the subsequent adsorption and reactions of water on Ru(0001) has been studied using low temperature scanning tunneling microscopy and DFT calculations. Experiments were carried out for O coverages close to 0.25 ML. It was found that no dissociation of water takes place up to the desorption temperature of {approx}180-230 K. DFT calculations show that intact water on O(2x2)/Ru(0001) is {approx} 0.49 eV more stable than the dissociation products, H and OH, at their preferred fcc and top adsorption sites.

  20. A 2x2 W-Band Reference Time-Shifted Phase-Locked Transmitter Array in 65nm CMOS Technology

    NASA Technical Reports Server (NTRS)

    Tang, Adrian; Virbila, Gabriel; Hsiao, Frank; Wu, Hao; Murphy, David; Mehdi, Imran; Siegel, P. H.; Chang, M-C. Frank

    2013-01-01

    This paper presents a complete 2x2 phased array transmitter system operating at W-band (90-95 GHz) which employs a PLL reference time-shifting approach instead of using traditional mm-wave phase shifters. PLL reference shifting enables a phased array to be distributed over multiple chips without the need for coherent mm-wave signal distribution between chips. The proposed phased array transmitter system consumes 248 mW per array element when implemented in a 65 nm CMOS technology.

  1. Super B Factory at KEK

    NASA Astrophysics Data System (ADS)

    Cheon, ByungGu

    2008-11-01

    A Super—KEKB factory, an asymmetric—energy e+e- lepton collider at KEK in Japan, has been proposed with the design peak luminosity of 8×1035 cm-2 s-1, which is about 50 times higher than that of the current operation of the KEKB collider. The physics goal of this project is mainly to measure extremely rare heavy flavor weak decays and CP violation phenomena, which are very sensitive on physics beyond the Standard Model. Hot physics topics and the status of experimental design are briefly described.

  2. Super B Factory at KEK

    SciTech Connect

    Cheon, Byung Gu

    2008-11-23

    A Super--KEKB factory, an asymmetric--energy e{sup +}e{sup -} lepton collider at KEK in Japan, has been proposed with the design peak luminosity of 8x10{sup 35} cm{sup -2} s{sup -1}, which is about 50 times higher than that of the current operation of the KEKB collider. The physics goal of this project is mainly to measure extremely rare heavy flavor weak decays and CP violation phenomena, which are very sensitive on physics beyond the Standard Model. Hot physics topics and the status of experimental design are briefly described.

  3. Gellan gum-based mucoadhesive microspheres of almotriptan for nasal administration: Formulation optimization using factorial design, characterization, and in vitro evaluation

    PubMed Central

    Abbas, Zaheer; Marihal, Sachin

    2014-01-01

    Background: Almotriptan malate (ALM), indicated for the treatment of migraine in adults is not a drug candidate feasible to be administered through the oral route during the attack due to its associated symptoms such as nausea and vomiting. This obviates an alternative dosage form and nasal drug delivery is a good substitute to oral and parenteral administration. Materials and Methods: Gellan gum (GG) microspheres of ALM, for intranasal administration were prepared by water-in-oil emulsification cross-linking technique employing a 23 factorial design. Drug to polymer ratio, calcium chloride concentration and cross-linking time were selected as independent variables, while particle size and in vitro mucoadhesion of the microspheres were investigated as dependent variables. Regression analysis was performed to identify the best formulation conditions. The microspheres were evaluated for characteristics such as practical percentage yield, particle size, percentage incorporation efficiency, swellability, zeta potential, in vitro mucoadhesion, thermal analysis, X-ray diffraction study, and in vitro drug diffusion studies. Results: The shape and surface characteristics of the microspheres were determined by scanning electron microscopy, which revealed spherical nature and nearly smooth surface with drug incorporation efficiency in the range of 71.65 ± 1.09% – 91.65 ± 1.13%. In vitro mucoadhesion was observed the range of 79.45 ± 1.69% – 95.48 ± 1.27%. Differential scanning calorimetry and X-ray diffraction results indicated a molecular level dispersion of drug in the microspheres. In vitro drug diffusion was Higuchi matrix controlled and the release mechanism was found to be non-Fickian. Stability studies indicated that there were no significant deviations in the drug content, in vitro mucoadhesion and in vitro drug diffusion characteristics. Conclusion: The investigation revealed promising potential of GG microspheres for delivering ALM intranasally for the

  4. Conceptuation, formulation and evaluation of sustained release floating tablets of captopril compression coated with gastric dispersible hydrochlorothiazide using 2(3) factorial design.

    PubMed

    Sirisha, Pathuri Lakshmi; Babu, Govada Kishore; Babu, Puttagunta Srinivasa

    2014-04-01

    Ambulatory blood pressure monitoring is regarded as the gold standard for hypertensive therapy in non-dipping hypertension patients. A novel compression coated formulation of captopril and hydrochlorothiazide (HCTZ) was developed in order to improve the efficacy of antihypertensive therapy considering the half-life of both drugs. The synergistic action using combination therapy can be effectively achieved by sustained release captopril (t1/2= 2.5 h) and fast releasing HCTZ (average t1/2= 9.5 h). The sustained release floating tablets of captopril were prepared by using 2(3) factorial design by employing three polymers i.e., ethyl cellulose (EC), carbopol and xanthan gum at two levels. The formulations (CF1-CF8) were optimized using analysis of variance for two response variables, buoyancy and T50%. Among the three polymers employed, the coefficients and P values for the response variable buoyancy and T50% using EC were found to be 3.824, 0.028 and 0.0196, 0.046 respectively. From the coefficients and P values for the two response variables, formulation CF2 was optimized, which contains EC polymer alone at a high level. The CF2 formulation was further compression coated with optimized gastric dispersible HCTZ layer (HF9). The compression coated tablet was further evaluated using drug release kinetics. The Q value of HCTZ layer is achieved within 20 min following first order release whereas the Q value of captopril was obtained at 6.5 h following Higuchi model, from which it is proved that rapid release HCTZ and slow release of captopril is achieved. The mechanism of drug release was analyzed using Peppas equation, which showed an n >0.90 confirming case II transportation mechanism for drug release.

  5. A novel homocystine-agarose adsorbent for separation and preconcentration of nickel in table salt and baking soda using factorial design optimization of the experimental conditions.

    PubMed

    Hashemi, Payman; Rahmani, Zohreh

    2006-02-28

    Homocystine was for the first time, chemically linked to a highly cross-linked agarose support (Novarose) to be employed as a chelating adsorbent for preconcentration and AAS determination of nickel in table salt and baking soda. Nickel is quantitatively adsorbed on a small column packed with 0.25ml of the adsorbent, in a pH range of 5.5-6.5 and simply eluted with 5ml of a 1moll(-1) hydrochloric acid solution. A factorial design was used for optimization of the effects of five different variables on the recovery of nickel. The results indicated that the factors of flow rate and column length, and the interactions between pH and sample volume are significant. In the optimized conditions, the column could tolerate salt concentrations up to 0.5moll(-1) and sample volumes beyond 500ml. Matrix ions of Mg(2+) and Ca(2+), with a concentration of 200mgl(-1), and potentially interfering ions of Cd(2+), Cu(2+), Zn(2+) and Mn(2+), with a concentration of 10mgl(-1), did not have significant effect on the analyte's signal. Preconcentration factors up to 100 and a detection limit of 0.49mugl(-1), corresponding to an enrichment volume of 500ml, were obtained for the determination of the analyte by flame AAS. Application of the method to the determination of natural and spiked nickel in table salt and baking soda solutions resulted in quantitative recoveries. Direct ETAAS determination of nickel in the same samples was not possible because of a high background observed. PMID:18970514

  6. A novel homocystine-agarose adsorbent for separation and preconcentration of nickel in table salt and baking soda using factorial design optimization of the experimental conditions.

    PubMed

    Hashemi, Payman; Rahmani, Zohreh

    2006-02-28

    Homocystine was for the first time, chemically linked to a highly cross-linked agarose support (Novarose) to be employed as a chelating adsorbent for preconcentration and AAS determination of nickel in table salt and baking soda. Nickel is quantitatively adsorbed on a small column packed with 0.25ml of the adsorbent, in a pH range of 5.5-6.5 and simply eluted with 5ml of a 1moll(-1) hydrochloric acid solution. A factorial design was used for optimization of the effects of five different variables on the recovery of nickel. The results indicated that the factors of flow rate and column length, and the interactions between pH and sample volume are significant. In the optimized conditions, the column could tolerate salt concentrations up to 0.5moll(-1) and sample volumes beyond 500ml. Matrix ions of Mg(2+) and Ca(2+), with a concentration of 200mgl(-1), and potentially interfering ions of Cd(2+), Cu(2+), Zn(2+) and Mn(2+), with a concentration of 10mgl(-1), did not have significant effect on the analyte's signal. Preconcentration factors up to 100 and a detection limit of 0.49mugl(-1), corresponding to an enrichment volume of 500ml, were obtained for the determination of the analyte by flame AAS. Application of the method to the determination of natural and spiked nickel in table salt and baking soda solutions resulted in quantitative recoveries. Direct ETAAS determination of nickel in the same samples was not possible because of a high background observed.

  7. HiPER Tritium factory elements

    NASA Astrophysics Data System (ADS)

    Guillaume, Didier

    2011-06-01

    HiPER will include a Tritium target factory. This presentation is an overview. We start from process ideas to go to first sketch passing through safety principles. We will follow the Tritium management process. We need first a gas factory producing the right gas mixture from hydrogen, Deuterium and Tritium storage. Then we could pass through the target factory. It is based on our LMJ single shot experiment and some new development like the injector. Then comes pellet burst and vapour recovery. The Tritium factory has to include the waste recovery, recycling process with gas purification before storage. At least, a nuclear plant is not a classical building. Tritium is also very special... All the design ideas have to be adapted. Many facilities are necessary, some with redundancy. We all have to well known these constraints. Tritium budget will be a major contributor for a material point of view as for a financial one.

  8. Perspective view of threestory reinforced concrete factory. The factory is ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view of three-story reinforced concrete factory. The factory is painted pink with factory windows infilling the structural frame exposed on the exterior facade. On the east facade of the three-story factory is a two-story, seven bay addition that is painted the same tone as the larger factory. The last two bays of the two-story addition are newer. A brick base surrounds both the factory and the addition and runs the entire length of the building on Clay Ave. and Morrow St. (Duplicate Color view of HAER MI-334-1) - Ivan Doverspike Company, 1925 Clay Avenue, Detroit, MI

  9. Perspective view of threestory reinforced concrete factory. The factory is ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view of three-story reinforced concrete factory. The factory is painted pink with factory windows infilling the structural frame exposed on the exterior facade. On the east facade of the three-story factory is a two-story, seven bay addition that is painted the same tone as the larger factory. The last two bays of the two-story addition are newer. A brick base surrounds both the factory and the addition and runs the entire length of the building on Clay Ave. and Morrow St - Ivan Doverspike Company, 1925 Clay Avenue, Detroit, MI

  10. Muon Colliders and Neutrino Factories

    SciTech Connect

    Kaplan, Daniel M.

    2015-05-29

    Muon colliders and neutrino factories are attractive options for future facilities aimed at achieving the highest lepton-antilepton collision energies and precision measurements of Higgs boson and neutrino mixing matrix parameters. The facility performance and cost depend on how well a beam of muons can be cooled. Recent progress in muon cooling design studies and prototype tests nourishes the hope that such facilities could be built starting in the coming decade. The status of the key technologies and their various demonstration experiments is summarized. Prospects "post-P5" are also discussed.

  11. The Clone Factory

    ERIC Educational Resources Information Center

    Stoddard, Beryl

    2005-01-01

    Have humans been cloned? Is it possible? Immediate interest is sparked when students are asked these questions. In response to their curiosity, the clone factory activity was developed to help them understand the process of cloning. In this activity, students reenact the cloning process, in a very simplified simulation. After completing the…

  12. The Invention Factory

    ERIC Educational Resources Information Center

    Speitel, Thomas W.; Scott, Neil G.; Gabrielli, Sandy D.

    2007-01-01

    The Invention Factory is a nontraditional youth-based, after-school program in Honolulu that teaches information technology and mechanics to teenagers through interactive, hands-on projects that improve human computer interaction for individuals with disabilities. One objective of the program is to stimulate interest in science and engineering…

  13. Electronic structure and thermoelectric properties of (Mg2X)2 / (Mg2Y)2 (X, Y = Si, Ge, Sn) superlattices from first-principle calculations

    NASA Astrophysics Data System (ADS)

    Guo, San-Dong

    2016-05-01

    To identify thermoelectric materials containing abundant, low-cost and non-toxic elements, we have studied the electronic structures and thermoelectric properties of (Mg2X)2/ (Mg2Y)2 (X, Y = Si, Ge, Sn) superlattices with state-of-the-art first-principles calculations using a modified Becke and Johnson (mBJ) exchange potential. Our results show that (Mg2Ge)2/ (Mg2Sn)2 and (Mg2Si)2/ (Mg2Sn)2 are semi-metals using mBJ plus spin-orbit coupling (mBJ + SOC), while (Mg2Si)2/ (Mg2Ge)2 is predicted to be a direct-gap semiconductor with a mBJ gap value of 0.46 eV and mBJ + SOC gap value of 0.44 eV. Thermoelectric properties are predicted by through solving the Boltzmann transport equations within the constant scattering time approximation. It is found that (Mg2Si)2/ (Mg2Ge)2 has a larger Seebeck coefficient and power factor than (Mg2Ge)2/ (Mg2Sn)2 and (Mg2Si)2/ (Mg2Sn)2 for both p-type and n-type doping. The detrimental influence of SOC on the power factor of p-type (Mg2X)2/ (Mg2Y)2 (X, Y = Si, Ge, Sn) is analyzed as a function of the carrier concentration, but there is a negligible SOC effect for n-type. These results can be explained by the influence of SOC on their valence and conduction bands near the Fermi level.

  14. Integrating PCLIPS into ULowell's Lincoln Logs: Factory of the future

    NASA Technical Reports Server (NTRS)

    Mcgee, Brenda J.; Miller, Mark D.; Krolak, Patrick; Barr, Stanley J.

    1990-01-01

    We are attempting to show how independent but cooperating expert systems, executing within a parallel production system (PCLIPS), can operate and control a completely automated, fault tolerant prototype of a factory of the future (The Lincoln Logs Factory of the Future). The factory consists of a CAD system for designing the Lincoln Log Houses, two workcells, and a materials handling system. A workcell consists of two robots, part feeders, and a frame mounted vision system.

  15. Identification of Analytical Factors Affecting Complex Proteomics Profiles Acquired in a Factorial Design Study with Analysis of Variance: Simultaneous Component Analysis.

    PubMed

    Mitra, Vikram; Govorukhina, Natalia; Zwanenburg, Gooitzen; Hoefsloot, Huub; Westra, Inge; Smilde, Age; Reijmers, Theo; van der Zee, Ate G J; Suits, Frank; Bischoff, Rainer; Horvatovich, Péter

    2016-04-19

    Complex shotgun proteomics peptide profiles obtained in quantitative differential protein expression studies, such as in biomarker discovery, may be affected by multiple experimental factors. These preanalytical factors may affect the measured protein abundances which in turn influence the outcome of the associated statistical analysis and validation. It is therefore important to determine which factors influence the abundance of peptides in a complex proteomics experiment and to identify those peptides that are most influenced by these factors. In the current study we analyzed depleted human serum samples to evaluate experimental factors that may influence the resulting peptide profile such as the residence time in the autosampler at 4 °C, stopping or not stopping the trypsin digestion with acid, the type of blood collection tube, different hemolysis levels, differences in clotting times, the number of freeze-thaw cycles, and different trypsin/protein ratios. To this end we used a two-level fractional factorial design of resolution IV (2(IV)(7-3)). The design required analysis of 16 samples in which the main effects were not confounded by two-factor interactions. Data preprocessing using the Threshold Avoiding Proteomics Pipeline (Suits, F.; Hoekman, B.; Rosenling, T.; Bischoff, R.; Horvatovich, P. Anal. Chem. 2011, 83, 7786-7794, ref 1) produced a data-matrix containing quantitative information on 2,559 peaks. The intensity of the peaks was log-transformed, and peaks having intensities of a low t-test significance (p-value > 0.05) and a low absolute fold ratio (<2) between the two levels of each factor were removed. The remaining peaks were subjected to analysis of variance (ANOVA)-simultaneous component analysis (ASCA). Permutation tests were used to identify which of the preanalytical factors influenced the abundance of the measured peptides most significantly. The most important preanalytical factors affecting peptide intensity were (1) the hemolysis level

  16. Identification of Analytical Factors Affecting Complex Proteomics Profiles Acquired in a Factorial Design Study with Analysis of Variance: Simultaneous Component Analysis.

    PubMed

    Mitra, Vikram; Govorukhina, Natalia; Zwanenburg, Gooitzen; Hoefsloot, Huub; Westra, Inge; Smilde, Age; Reijmers, Theo; van der Zee, Ate G J; Suits, Frank; Bischoff, Rainer; Horvatovich, Péter

    2016-04-19

    Complex shotgun proteomics peptide profiles obtained in quantitative differential protein expression studies, such as in biomarker discovery, may be affected by multiple experimental factors. These preanalytical factors may affect the measured protein abundances which in turn influence the outcome of the associated statistical analysis and validation. It is therefore important to determine which factors influence the abundance of peptides in a complex proteomics experiment and to identify those peptides that are most influenced by these factors. In the current study we analyzed depleted human serum samples to evaluate experimental factors that may influence the resulting peptide profile such as the residence time in the autosampler at 4 °C, stopping or not stopping the trypsin digestion with acid, the type of blood collection tube, different hemolysis levels, differences in clotting times, the number of freeze-thaw cycles, and different trypsin/protein ratios. To this end we used a two-level fractional factorial design of resolution IV (2(IV)(7-3)). The design required analysis of 16 samples in which the main effects were not confounded by two-factor interactions. Data preprocessing using the Threshold Avoiding Proteomics Pipeline (Suits, F.; Hoekman, B.; Rosenling, T.; Bischoff, R.; Horvatovich, P. Anal. Chem. 2011, 83, 7786-7794, ref 1) produced a data-matrix containing quantitative information on 2,559 peaks. The intensity of the peaks was log-transformed, and peaks having intensities of a low t-test significance (p-value > 0.05) and a low absolute fold ratio (<2) between the two levels of each factor were removed. The remaining peaks were subjected to analysis of variance (ANOVA)-simultaneous component analysis (ASCA). Permutation tests were used to identify which of the preanalytical factors influenced the abundance of the measured peptides most significantly. The most important preanalytical factors affecting peptide intensity were (1) the hemolysis level

  17. A Randomized 2x2 Factorial Clinical Trial of Renal Transplantation: Steroid-Free Maintenance Immunosuppression with Calcineurin Inhibitor Withdrawal after Six Months Associates with Improved Renal Function and Reduced Chronic Histopathology

    PubMed Central

    Stevens, R. Brian; Foster, Kirk W.; Miles, Clifford D.; Kalil, Andre C.; Florescu, Diana F.; Sandoz, John P.; Rigley, Theodore H.; Malik, Tamer; Wrenshall, Lucile E.

    2015-01-01

    Introduction The two most significant impediments to renal allograft survival are rejection and the direct nephrotoxicity of the immunosuppressant drugs required to prevent it. Calcineurin inhibitors (CNI), a mainstay of most immunosuppression regimens, are particularly nephrotoxic. Until less toxic antirejection agents become available, the only option is to optimize our use of those at hand. Aim To determine whether intensive rabbit anti-thymocyte globulin (rATG) induction followed by CNI withdrawal would individually or combined improve graft function and reduce graft chronic histopathology–surrogates for graft and, therefore, patient survival. As previously reported, a single large rATG dose over 24 hours was well-tolerated and associated with better renal function, fewer infections, and improved patient survival. Here we report testing whether complete CNI discontinuation would improve renal function and decrease graft pathology. Methods Between April 20, 2004 and 4-14-2009 we conducted a prospective, randomized, non-blinded renal transplantation trial of two rATG dosing protocols (single dose, 6 mg/kg vs. divided doses, 1.5 mg/kg every other day x 4; target enrollment = 180). Subsequent maintenance immunosuppression consisted of tacrolimus, a CNI, and sirolimus, a mammalian target of rapamycin inhibitor. We report here the outcome of converting patients after six months either to minimized tacrolimus/sirolimus or mycophenolate mofetil/sirolimus. Primary endpoints were graft function and chronic histopathology from protocol kidney biopsies at 12 and 24 months Results CNI withdrawal (on-treatment analysis) associated with better graft function (p <0.001) and lower chronic histopathology composite scores in protocol biopsies at 12 (p = 0.003) and 24 (p = 0.013) months, without affecting patient (p = 0.81) or graft (p = 0.93) survival, or rejection rate (p = 0.17). Conclusion CNI (tacrolimus) withdrawal at six months may provide a strategy for decreased nephrotoxicity and improved long-term function in steroid-free low immunological risk renal transplant patients. Trial Registration ClinicalTrials.gov NCT00556933 PMID:26465152

  18. Sequence Factorial and Its Applications

    ERIC Educational Resources Information Center

    Asiru, Muniru A.

    2012-01-01

    In this note, we introduce sequence factorial and use this to study generalized M-bonomial coefficients. For the sequence of natural numbers, the twin concepts of sequence factorial and generalized M-bonomial coefficients, respectively, extend the corresponding concepts of factorial of an integer and binomial coefficients. Some latent properties…

  19. The Super Flavor Factory

    SciTech Connect

    Bevan, A.J.; /Queen Mary, U. of London

    2007-01-26

    The main physics goals of a high luminosity e{sup +}e{sup -} flavor factory are discussed, including the possibilities to perform detailed studies of the CKM mechanism of quark mixing, and constrain virtual Higgs and Non-Standard Model particle contributions to the dynamics of rare B{sub u,d,s} decays. The large samples of D mesons and {tau} leptons produced at a flavor factory will result in improved sensitivities on D mixing and lepton flavor violation searches, respectively. One can also test fundamental concepts such as lepton universality to much greater precision than existing constraints and improve the precision on tests of CPT from B meson decays. Recent developments in accelerator physics have demonstrated the feasibility to build an accelerator that can achieve luminosities of {Omicron}(10{sup 36} cm{sup -2} s{sup -1}).

  20. SLAC B Factory computing

    SciTech Connect

    Kunz, P.F.

    1992-02-01

    As part of the research and development program in preparation for a possible B Factory at SLAC, a group has been studying various aspects of HEP computing. In particular, the group is investigating the use of UNIX for all computing, from data acquisition, through analysis, and word processing. A summary of some of the results of this study will be given, along with some personal opinions on these topics.

  1. B-factories

    SciTech Connect

    Bloom, E.D.

    1988-04-01

    We briefly review the physics of CP violation and the interest of studying this phenomenon in the B-meson system. The need for very large numbers of B-decays is shown, and a number of approaches for B-factories are compared. In particular, e/sup +/e/sup /minus// linear and circular colliders are discussed in some detail, with specific examples presented. 31 refs., 22 figs., 5 tabs.

  2. EMIR data factory system

    NASA Astrophysics Data System (ADS)

    Rosich Minguell, Josefina; Barreto, M.; Castro, N.; Garzón, F.; Guerra, D.; Insausti, M.; López-Martín, L.; López, P.; Molgó, J.; Patrón, J.

    2014-07-01

    EMIR (Espectrógrafo Multiobjeto Infrarrojo) is a wide-field, near-infrared, multi-object spectrograph, with image capabilities, which will be located at the Nasmyth focus of GTC (Gran Telescopio Canarias). It will allow observers to obtain many intermediate resolution spectra simultaneously, in the nIR bands Z, J, H, K. A multi-slit mask unit will be used for target acquisition. This paper shows an overview of EMIR Data Factory System which main functionality is to receive raw images from DAS (Data Acquisition system), collect FITS header keywords, store images to database and propagate images to other GCS (GTC Control System) components to produce astronomical data. This system follows the standards defined by the telescope to permit the integration of this software on the GCS. The Data Factory System needs the DAS, the Sequencer, GUI and the Monitor Manager subsystems to operate. DAS generates images and sends them to the Data Factory. Sequencer and GUI (Graphical User Interface) provide information about instrument and observing program. The Monitor Manager supplies information about telescope and instrument state.

  3. Muon Front-End for the Neutrino Factory

    NASA Astrophysics Data System (ADS)

    Fernow, R. C.

    2006-05-01

    The front end at a neutrino factory includes all the systems necessary for capturing the pion beam produced at the target and for preparing the transverse and longitudinal phase space of the resulting muon beam for subsequent acceleration to high energies. We compare front end configurations for a number of neutrino factory designs.

  4. Born-Oppenheimer and Renner-Teller coupled-channel quantum reaction dynamics of O((3)P) + H2(+)(X(2)Σg(+)) collisions.

    PubMed

    Gamallo, Pablo; Defazio, Paolo; González, Miguel; Paniagua, Miguel; Petrongolo, Carlo

    2015-09-28

    We present Born-Oppenheimer (BO) and Renner-Teller (RT) time dependent quantum dynamics studies of the reactions O((3)P) + H2(+)(X(2)Σg(+)) → OH(+)(X(3)Σ(-)) + H((2)S) and OH(X(2)Π) + H(+). We consider the OH2(+) X[combining tilde](2)A'' and Ã(2)A' electronic states that correlate with a linear (2)Π species. The electronic angular momenta operators L[combining circumflex] and L[combining circumflex](2) are considered in nonadiabatic coupled-channel calculations, where the associated RT effects are due to diagonal V(RT) potentials that add up to the PESs and to off-diagonal C(RT) couplings between the potential energy surfaces (PESs). Initial-state-resolved reaction probabilities PI, integral cross sections σI, and rate constants kI are obtained using recent ab initio PESs and couplings and the real wavepacket formalism. Because the PESs are strongly attractive, PI have no threshold energy and are large, σI decrease with collision energy, and kI depend little on the temperature. The X[combining tilde](2)A'' PES is up to three times more reactive than the Ã(2)A' PES and H2(+) rotational effects (j0 = 0, 1) are negligible. The diagonal V(RT) potentials are strongly repulsive at the collinearity and nearly halve all low-energy observables with respect to the BO ones. The off-diagonal C(RT) couplings are important at low partial waves, where they mix the X[combining tilde](2)A'' and Ã(2)A' states up to ∼20%. However, V(RT) effects predominate over the C(RT) ones that change at most by ∼19% the BO values of σI and kI. The reaction O((3)P) + H2(+)(X(2)Σg(+)) → OH(+)(X(3)Σ(-)) + H((2)S) is probably one of the most reactive atom + diatom collisions because its RT rate constant at room temperature is equal to 2.26 × 10(-10) cm(3) s(-1). Within the BO approximation, the present results agree rather well with recent quasiclassical and centrifugal-sudden data using the same PESs.

  5. Multivariate optimization of process parameters in the synthesis of calcined Ca‒Al (NO3) LDH for defluoridation using 3(3) factorial, central composite and Box-Behnken design.

    PubMed

    Ghosal, Partha S; Gupta, Ashok K; Sulaiman, Ayoob

    2016-01-01

    Response surface methodology was applied for the first time in the optimization of the preparation of layered double hydroxide (LDH) for defluoridation. The influence of three vital process parameters (viz. pH, molar ratio and calcination temperature) in the synthesis of the adsorbent 'Calcined Ca‒Al (NO3) LDH' was thoroughly examined to maximize its fluoride scavenging potential. The process parameters were optimized using the 3(3) factorial, face centered central composite and Box-Behnken designs and a comparative assessment of the methods was conducted. The maximum fluoride removal efficiency was achieved at a calcination temperature of approximately 500ºC; however, the efficiency decreased with increasing pH and molar ratio. The outcome of the comparative assessment clearly delineates the case specific nature of the models. A better predictability over the entire experimental domain was obtained with the 3(3) factorial method, whereas the Box-Behnken design was found to be the most efficient model with lesser number of experimental runs. The desirability function technique was performed for optimizing the response, wherein face centered central composite design exhibited a maximum desirability. The calcined Ca‒Al (NO3) LDH, synthesized under the optimum conditions, demonstrated the removal efficiencies of 95% and 99% for the doses of 3 g L(-1) and 5 g L(-1), respectively.

  6. Multivariate optimization of process parameters in the synthesis of calcined Ca‒Al (NO3) LDH for defluoridation using 3(3) factorial, central composite and Box-Behnken design.

    PubMed

    Ghosal, Partha S; Gupta, Ashok K; Sulaiman, Ayoob

    2016-01-01

    Response surface methodology was applied for the first time in the optimization of the preparation of layered double hydroxide (LDH) for defluoridation. The influence of three vital process parameters (viz. pH, molar ratio and calcination temperature) in the synthesis of the adsorbent 'Calcined Ca‒Al (NO3) LDH' was thoroughly examined to maximize its fluoride scavenging potential. The process parameters were optimized using the 3(3) factorial, face centered central composite and Box-Behnken designs and a comparative assessment of the methods was conducted. The maximum fluoride removal efficiency was achieved at a calcination temperature of approximately 500ºC; however, the efficiency decreased with increasing pH and molar ratio. The outcome of the comparative assessment clearly delineates the case specific nature of the models. A better predictability over the entire experimental domain was obtained with the 3(3) factorial method, whereas the Box-Behnken design was found to be the most efficient model with lesser number of experimental runs. The desirability function technique was performed for optimizing the response, wherein face centered central composite design exhibited a maximum desirability. The calcined Ca‒Al (NO3) LDH, synthesized under the optimum conditions, demonstrated the removal efficiencies of 95% and 99% for the doses of 3 g L(-1) and 5 g L(-1), respectively. PMID:26549036

  7. Rovibrationally selected ion-molecule collision study using the molecular beam vacuum ultraviolet laser pulsed field ionization-photoion method: Charge transfer reaction of N2+(X 2Σg+; v+ = 0-2; N+ = 0-9) + Ar

    NASA Astrophysics Data System (ADS)

    Chang, Yih Chung; Xu, Yuntao; Lu, Zhou; Xu, Hong; Ng, C. Y.

    2012-09-01

    We have developed an ion-molecule reaction apparatus for state-selected absolute total cross section measurements by implementing a high-resolution molecular beam vacuum ultraviolet (VUV) laser pulsed field ionization-photoion (PFI-PI) ion source to a double-quadrupole double-octopole ion-guide mass spectrometer. Using the total cross section measurement of the state-selected N2+(v+, N+) + Ar charge transfer (CT) reaction as an example, we describe in detail the design of the VUV laser PFI-PI ion source used, which has made possible the preparation of reactant N2+(X 2Σg+, v+ = 0-2, N+ = 0-9) PFI-PIs with high quantum state purity, high intensity, and high kinetic energy resolution. The PFI-PIs and prompt ions produced in the ion source are shown to have different kinetic energies, allowing the clean rejection of prompt ions from the PFI-PI beam by applying a retarding potential barrier upstream of the PFI-PI source. By optimizing the width and amplitude of the pulsed electric fields employed to the VUV-PFI-PI source, we show that the reactant N2+ PFI-PI beam can be formed with a laboratory kinetic energy resolution of ΔElab = ± 50 meV. As a result, the total cross section measurement can be conducted at center-of-mass kinetic energies (Ecm's) down to thermal energies. Absolute total rovibrationally selected cross sections σ(v+ = 0-2, N+ = 0-9) for the N2+(X 2Σg+; v+ = 0-2, N+ = 0-9) + Ar CT reaction have been measured in the Ecm range of 0.04-10.0 eV, revealing strong vibrational enhancements and Ecm-dependencies of σ(v+ = 0-2, N+ = 0-9). The thermochemical threshold at Ecm = 0.179 eV for the formation of Ar+ from N2+(X; v+ = 0, N+) + Ar was observed by the measured σ(v+ = 0), confirming the narrow ΔEcm spread achieved in the present study. The σ(v+ = 0-2; N+) values obtained here are compared with previous experimental and theoretical results. The theoretical predictions calculated based on the Landau-Zener-Stückelberg formulism are found to be in fair

  8. Adsorption site and structure determination of c(2x2) N{sub 2}/Ni(100) using angle-resolved photoemission extended fine structure

    SciTech Connect

    Moler, E.J.; Kellar, S.A.; Huff, W.R.A.

    1997-04-01

    The authors have determined the atomic spatial structure of c(2x2) N2Ni(100) with Angle-Resolved Photoemission Extended Fine Structure (ARPEFS) from the nitrogen 1s core level using monochromatized x-rays from beamline 6.1 at SSRL and beamline 9.3.2 at the ALS. The chemically shifted N 1s peak intensities were summed together to obtain ARPEFS curves for both nitrogen atoms in the molecule. They used a new, highly-optimized program based on the Rehr-Albers scattering matrix formalism to find the adsorption site and to quantitatively determine the bond-lengths. The nitrogen molecule stands upright at an atop site, with a N-Ni bond length of 2.25(1) {angstrom}, a N-N bond length of 1.10(7) {angstrom}, and a first layer Ni-Ni spacing of 1.76(4) {angstrom}. The shake-up peak shows an identical ARPEFS diffraction pattern, confirming its intrinsic nature and supporting a previous use of this feature to decompose the peak into contributions from the chemically inequivalent nitrogen atoms. Comparison to a previously published theoretical treatment of N-N-Ni and experimental structures of analogous adsorbate systems demonstrates the importance of adsorbate-adsorbate interactions in weakly chemisorbed systems.

  9. The Nicotinic α6 Subunit Gene Determines Variability in Chronic Pain Sensitivity via Cross-inhibition of P2X2/3 Receptors

    PubMed Central

    Wieskopf, Jeffrey S.; Mathur, Jayanti; Limapichat, Walrati; Post, Michael R.; Al-Qazzaz, Mona; Sorge, Robert E.; Martin, Loren J.; Zaykin, Dmitri V.; Smith, Shad B.; Freitas, Kelen; Austin, Jean-Sebastien; Dai, Feng; Zhang, Jie; Marcovitz, Jaclyn; Tuttle, Alexander H.; Slepian, Peter M.; Clarke, Sarah; Drenan, Ryan M.; Janes, Jeff; Sharari, Shakir Al; Segall, Samantha K.; Aasvang, Eske K.; Lai, Weike; Bittner, Reinhard; Richards, Christopher I.; Slade, Gary D.; Kehlet, Henrik; Walker, John; Maskos, Uwe; Changeux, Jean-Pierre; Devor, Marshall; Maixner, William; Diatchenko, Luda; Belfer, Inna; Dougherty, Dennis A.; Su, Andrew I.; Lummis, Sarah C.R.; Damaj, M. Imad; Lester, Henry A.; Patapoutian, Ardem; Mogil, Jeffrey S.

    2016-01-01

    Chronic pain is a highly prevalent and poorly managed human health problem. We used microarray-based expression genomics in 25 inbred mouse strains to identify dorsal root ganglion (DRG)-expressed genetic contributors to mechanical allodynia, a prominent symptom of chronic pain. We identified expression levels of Chrna6, which encodes the α6 subunit of the nicotinic acetylcholine receptor (nAChR), as highly associated with allodynia. We confirmed the importance of α6* (i.e., α6-containing) nAChRs by analyzing both gain- and loss-of-function mutants. We find that mechanical allodynia associated with neuropathic and inflammatory injuries is significantly altered in α6* mutants, and that α6* but not α4* nicotinic receptors are absolutely required for peripheral and/or spinal nicotine analgesia. Furthermore, we show that Chrna6’s role in analgesia is at least partially due to direct interaction and cross-inhibition of α6* nAChRs with P2X2/3 receptors in DRG nociceptors. Finally, we establish relevance of our results to humans by the observation of genetic association in patients suffering from chronic postsurgical pain and temporomandibular pain. PMID:25972004

  10. Hazardous factories: Nigerian evidence.

    PubMed

    Oloyede, Olajide

    2005-06-01

    The past 15 years have seen an increasing governmental and corporate concern for the environment worldwide. For governments, information about the environmental performance of the industrial sector is required to inform macro-level decisions about environmental targets such as those required to meet UN directives. However, in many African, Asian, and Latin American countries, researching and reporting company environmental performance is limited. This article serves as a contribution to filling the gap by presenting evidence of physical and chemical risk in Nigerian factories. One hundred and three factories with a total of 5,021 workers were studied. One hundred and twenty physical and chemical hazards were identified and the result shows a high number of workers exposed to such hazards. The study also reveals that workers' awareness level of chemical hazards was high. Yet the danger was perceived in behavioral terms, especially by manufacturing firms, which tend to see environmental investment in an increasingly global economy as detrimental to profitability. PMID:16022703

  11. Residual Chemoresponsiveness to Acids in the Superior Laryngeal Nerve in “Taste-Blind” (P2X2/P2X3 Double-KO) Mice

    PubMed Central

    Ohkuri, Tadahiro; Horio, Nao; Stratford, Jennifer M.; Finger, Thomas E.; Ninomiya, Yuzo

    2012-01-01

    Mice lacking both the P2X2 and the P2X3 purinergic receptors (P2X-dblKO) exhibit loss of responses to all taste qualities in the taste nerves innervating the tongue. Similarly, these mice exhibit a near total loss of taste-related behaviors in brief access tests except for a near-normal avoidance of acidic stimuli. This persistent avoidance of acids despite the loss of gustatory neural responses to sour was postulated to be due to continued responsiveness of the superior laryngeal (SL) nerve. However, chemoresponses of the larynx are attributable both to taste buds and to free nerve endings. In order to test whether the SL nerve of P2X-dblKO mice remains responsive to acids but not to other tastants, we recorded responses from the SL nerve in wild-type (WT) and P2X-dblKO mice. WT mice showed substantial SL responses to monosodium glutamate, sucrose, urea, and denatonium—all of which were essentially absent in P2X-dblKO animals. In contrast, the SL nerve of P2X-dblKO mice exhibited near-normal responses to citric acid (50 mM) although responsiveness of both the chorda tympani and the glossopharyngeal nerves to this stimulus were absent or greatly reduced. These results are consistent with the hypothesis that the residual avoidance of acidic solutions by P2X-dblKO mice may be attributable to the direct chemosensitivity of nerve fibers innervating the laryngeal epithelium and not to taste. PMID:22362867

  12. Sequence factorial and its applications

    NASA Astrophysics Data System (ADS)

    Asiru, Muniru A.

    2012-06-01

    In this note, we introduce sequence factorial and use this to study generalized M-bonomial coefficients. For the sequence of natural numbers, the twin concepts of sequence factorial and generalized M-bonomial coefficients, respectively, extend the corresponding concepts of factorial of an integer and binomial coefficients. Some latent properties of generalized M-bonomial coefficients by which a vast majority of practical problems involving generalized M-bonomial coefficients can be solved are derived.

  13. Factorial Experiments: Efficient Tools for Evaluation of Intervention Components

    PubMed Central

    Collins, Linda M.; Dziak, John J.; Kugler, Kari C.; Trail, Jessica B.

    2014-01-01

    Background An understanding of the individual and combined effects of a set of intervention components is important for moving the science of preventive medicine interventions forward. This understanding can often be achieved in an efficient and economical way via a factorial experiment, in which two or more independent variables are manipulated. The factorial experiment is a complement to the randomized controlled trial (RCT); the two designs address different research questions. Purpose This article offers an introduction to factorial experiments aimed at investigators trained primarily in the RCT. Method The factorial experiment is compared and contrasted with other experimental designs used commonly in intervention science to highlight where each is most efficient and appropriate. Results Several points are made: factorial experiments make very efficient use of experimental subjects when the data are properly analyzed; a factorial experiment can have excellent statistical power even if it has relatively few subjects per experimental condition; and when conducting research to select components for inclusion in a multicomponent intervention, interactions should be studied rather than avoided. Conclusions Investigators in preventive medicine and related areas should begin considering factorial experiments alongside other approaches. Experimental designs should be chosen from a resource management perspective, which states that the best experimental design is the one that provides the greatest scientific benefit without exceeding available resources. PMID:25092122

  14. The eldercare factory.

    PubMed

    Sharkey, Noel; Sharkey, Amanda

    2012-01-01

    Rapid advances in service robotics together with dramatic shifts in population demographics have led to the notion that technology may be the answer to our eldercare problems. Robots are being developed for feeding, washing, lifting, carrying and mobilising the elderly as well as monitoring their health. They are also being proposed as a substitute for companionship. While these technologies could accrue major benefits for society and empower the elderly, we must balance their use with the ethical costs. These include a potential reduction in human contact, increased feeling of objectification and loss of control, loss of privacy and personal freedom as well as deception and infantilisation. With appropriate guidelines in place before the introduction of robots en masse into the care system, robots could improve the lives of the elderly, reducing their dependence and creating more opportunities for social interaction. Without forethought, the elderly may find themselves in a barren world of machines, a world of automated care: a factory for the elderly.

  15. The crystal chemistry of Ca(10-y)(SiO4)3(SO4)3Cl(2-x-2y)F(x) ellestadite.

    PubMed

    Fang, Yanan; Ritter, Clemens; White, Tim

    2011-12-19

    Fluor-chlorellestadite solid solutions Ca(10)(SiO(4))(3)(SO(4))(3)Cl(2-x)F(x), serving as prototype crystalline matrices for the fixation of hazardous fly ash, were synthesized and characterized by powder X-ray and neutron diffraction (PXRD and PND), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). The lattice parameters of the ellestadites vary linearly with composition and show the expected shrinkage of unit cell volume as fluorine (IR = 1.33 Å) displaces chlorine (IR = 1.81 Å). FTIR spectra indicate little or no OH(-) in the solid solutions. All compositions conform to P6(3)/m symmetry where F(-) is located at the 2a (0, 0, (1)/(4)) position, while Cl(-) is displaced out of the 6h Ca(2) triangle plane and occupies 4e (0, 0, z) split positions with z ranging from 0.336(3) to 0.4315(3). Si/S randomly occupy the 6h tetrahedral site. Ellestadites rich in Cl (x ≤ 1.2) show an overall deficiency in halogens (<2 atom per formula unit), particularly Cl as a result of CaCl(2) volatilization, with charge balance achieved by the creation of Ca vacancies (Ca(2+) + 2Cl(-) →□(Ca) + 2□(Cl)) leading to the formula Ca(10-y)(SiO(4))(3)(SO(4))(3)Cl(2-x-2y)F(x). For F-rich compositions the vacancies are found at Ca(2), while for Cl-rich ellestadites, vacancies are at Ca(1). It is likely the loss of CaCl(2) which leads tunnel anion vacancies promotes intertunnel positional disorder, preventing the formation of a P2(1)/b monoclinic dimorph, analogous to that reported for Ca(10)(PO(4))(6)Cl(2). Trends in structure with composition were analyzed using crystal-chemical parameters, whose systematic variations served to validate the quality of the Rietveld refinements. PMID:22111559

  16. The crystal chemistry of Ca(10-y)(SiO4)3(SO4)3Cl(2-x-2y)F(x) ellestadite.

    PubMed

    Fang, Yanan; Ritter, Clemens; White, Tim

    2011-12-19

    Fluor-chlorellestadite solid solutions Ca(10)(SiO(4))(3)(SO(4))(3)Cl(2-x)F(x), serving as prototype crystalline matrices for the fixation of hazardous fly ash, were synthesized and characterized by powder X-ray and neutron diffraction (PXRD and PND), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). The lattice parameters of the ellestadites vary linearly with composition and show the expected shrinkage of unit cell volume as fluorine (IR = 1.33 Å) displaces chlorine (IR = 1.81 Å). FTIR spectra indicate little or no OH(-) in the solid solutions. All compositions conform to P6(3)/m symmetry where F(-) is located at the 2a (0, 0, (1)/(4)) position, while Cl(-) is displaced out of the 6h Ca(2) triangle plane and occupies 4e (0, 0, z) split positions with z ranging from 0.336(3) to 0.4315(3). Si/S randomly occupy the 6h tetrahedral site. Ellestadites rich in Cl (x ≤ 1.2) show an overall deficiency in halogens (<2 atom per formula unit), particularly Cl as a result of CaCl(2) volatilization, with charge balance achieved by the creation of Ca vacancies (Ca(2+) + 2Cl(-) →□(Ca) + 2□(Cl)) leading to the formula Ca(10-y)(SiO(4))(3)(SO(4))(3)Cl(2-x-2y)F(x). For F-rich compositions the vacancies are found at Ca(2), while for Cl-rich ellestadites, vacancies are at Ca(1). It is likely the loss of CaCl(2) which leads tunnel anion vacancies promotes intertunnel positional disorder, preventing the formation of a P2(1)/b monoclinic dimorph, analogous to that reported for Ca(10)(PO(4))(6)Cl(2). Trends in structure with composition were analyzed using crystal-chemical parameters, whose systematic variations served to validate the quality of the Rietveld refinements.

  17. Application of factorial design and Doehlert matrix for determination of trace lead in environmental samples by on-line column preconcentration FAAS using silica gel chemically modified with niobium(V) oxide.

    PubMed

    Roux, Kalya Cravo Di Pietro; Maltez, Heloisa França; Carletto, Jeferson Schneider; Martendal, Edmar; Carasek, Eduardo

    2008-03-01

    In this study a new method for Pb determination in water using solid phase extraction coupled to a flow injection system and flame atomic absorption spectrometry was developed. The sorbent used for Pb preconcentration and extraction was silica gel chemically modified with niobium(V) oxide. Flow and chemical variables of the system were optimized through a multivariate procedure. The factors selected were buffer type, eluent concentration, and sample and eluent flow rates. It was verified that the aforementioned factors as well as their interactions were statistically significant at the 95% confidence level. The effect of foreign ions was evaluated using a fractionary factorial experimental design. The detection limit was 0.35 microg L(-1) and the precision was 1.6%. Results for recovery tests using different environmental samples were between 90 and 104%. Certified reference materials were analyzed in order to check the accuracy of the proposed method. PMID:18332544

  18. Electropolishing of Re-melted SLM Stainless Steel 316L Parts Using Deep Eutectic Solvents: 3 × 3 Full Factorial Design

    NASA Astrophysics Data System (ADS)

    Alrbaey, K.; Wimpenny, D. I.; Al-Barzinjy, A. A.; Moroz, A.

    2016-07-01

    This three-level three-factor full factorial study describes the effects of electropolishing using deep eutectic solvents on the surface roughness of re-melted 316L stainless steel samples produced by the selective laser melting (SLM) powder bed fusion additive manufacturing method. An improvement in the surface finish of re-melted stainless steel 316L parts was achieved by optimizing the processing parameters for a relatively environmentally friendly (`green') electropolishing process using a Choline Chloride ionic electrolyte. The results show that further improvement of the response value-average surface roughness ( Ra) can be obtained by electropolishing after re-melting to yield a 75% improvement compared to the as-built Ra. The best Ra value was less than 0.5 μm, obtained with a potential of 4 V, maintained for 30 min at 40 °C. Electropolishing has been shown to be effective at removing the residual oxide film formed during the re-melting process. The material dissolution during the process is not homogenous and is directed preferentially toward the iron and nickel, leaving the surface rich in chromium with potentially enhanced properties. The re-melted and polished surface of the samples gave an approximately 20% improvement in fatigue life at low stresses (approximately 570 MPa). The results of the study demonstrate that a combination of re-melting and electropolishing provides a flexible method for surface texture improvement which is capable of delivering a significant improvement in surface finish while holding the dimensional accuracy of parts within an acceptable range.

  19. Muon front end for the neutrino factory

    NASA Astrophysics Data System (ADS)

    Rogers, C. T.; Stratakis, D.; Prior, G.; Gilardoni, S.; Neuffer, D.; Snopok, P.; Alekou, A.; Pasternak, J.

    2013-04-01

    In the neutrino factory, muons are produced by firing high-energy protons onto a target to produce pions. The pions decay to muons and pass through a capture channel known as the muon front end, before acceleration to 12.6 GeV. The muon front end comprises a variable frequency rf system for longitudinal capture and an ionization cooling channel. In this paper we detail recent improvements in the design of the muon front end.

  20. Status of the Super B Factory Projects

    SciTech Connect

    Sangro, Riccardo de

    2010-08-05

    Two proposals have been presented for the construction of super high luminosity B factories, the SuperB in Italy and SuperKEKB in Japan. We review the physics case for the construction of such facilities in the LHC era and highlight several topics of hadronic physics that can benefit from the high luminosity they will integrate. The present status of the accelerator and detector work toward the Technical Design Reports is also presented.

  1. An asymmetric B factory based on PEP

    SciTech Connect

    Not Available

    1991-02-01

    In this report we describe a design for a high-luminosity Asymmetric B Factory to be built in the PEP tunnel on the SLAC site. This proposal, a collaborative effort SLAC, LBL, and LLNL, is the culmination of more than two years of effort aimed at the design and construction of an asymmetric e{sup +}e{sup {minus}} collider capable of achieving a luminosity of L = 3 {times} 10{sup 33} cm{sup {minus}2} s{sup {minus}1}. The configuration adopted utilizes two storage rings, and electron ring operating at 9 GeV and a positron ring at 3.1 GeV, each with a circumference of 2200 m. The high-energy ring is an upgrade of the PEP storage ring at SLAC; all PEP magnets and most power supplies will be reused. The upgrade consists primarily of replacing the PEP vacuum chamber and RF system with newly designed versions optimized for the high-current environment of the B Factory. The low-energy ring will be newly constructed and will be situated atop the high-energy ring in the PEP tunnel. Utilities already installed in the PEP tunnel are largely sufficient to operate the two B Factory storage rings.

  2. Laser-cooled radioactive francium factory at CYRIC

    NASA Astrophysics Data System (ADS)

    Kawamura, Hirokazu; Arikawa, H.; Ezure, S.; Harada, K.; Hayamizu, T.; Inoue, T.; Ishikawa, T.; Itoh, M.; Kato, T.; Sato, T.; Aoki, T.; Furukawa, T.; Hatakeyama, A.; Hatanaka, K.; Imai, K.; Murakami, T.; Nataraj, H. S.; Shimizu, Y.; Wakasa, T.; Yoshida, H. P.; Sakemi, Y.

    2013-12-01

    A factory of laser-cooled francium (Fr) atoms is being developed to search for the electric dipole moment (EDM) of the electron. The factory has achieved the production of Fr ions of 9 × 105 particles/s and transport with a transmission efficiency of 2%. In pilot experiments, the magneto-optical trapping of rubidium (Rb) has been performed using a new ion-to-atom converter. To achieve the Fr trap, the development and design of each of the factory's components are in progress.

  3. Pion Production for Neutrino Factory-challenges

    NASA Astrophysics Data System (ADS)

    Breton, Florian; Couedic, Clément Le; Soler, F. J. P.

    2011-10-01

    One of the key issues in the design of a Neutrino Factory target station is the determination of the optimum kinetic energy of the proton beam due to the large uncertainties in simulations of protons impinging on nuclear targets. In this paper we have developed a procedure to correct GEANT4 simulations for the HARP data, and we have determined the yield of muons expected at the front-end of a Neutrino Factory as a function of target material (Be, C, Al, Ta and Pb) and energy (3-12 GeV).The maximum muon yield is found between 5 and 8 GeV for high Z targets and 3 GeV for low Z targets.

  4. Pion Production for Neutrino Factory-challenges

    SciTech Connect

    Breton, Florian; Le Couedic, Clement; Soler, F. J. P.

    2011-10-06

    One of the key issues in the design of a Neutrino Factory target station is the determination of the optimum kinetic energy of the proton beam due to the large uncertainties in simulations of protons impinging on nuclear targets. In this paper we have developed a procedure to correct GEANT4 simulations for the HARP data, and we have determined the yield of muons expected at the front-end of a Neutrino Factory as a function of target material (Be, C, Al, Ta and Pb) and energy (3-12 GeV).The maximum muon yield is found between 5 and 8 GeV for high Z targets and 3 GeV for low Z targets.

  5. On the Expectations of Mean Squares Based on Nonindependent Variates in Factorials.

    ERIC Educational Resources Information Center

    Draper, John F.

    A study was made of the problem of representing the expectations of mean squares associated with analysis of variance sources of variation for experimental designs. These designs have a factorial structure over repeated measures or, for some other reason, have variates within a factorial design not all of which are mutually independent. A simple…

  6. Design of a surface-based factory for the production of life support and technology support products. Phase 2: Integrated water system for a space colony

    NASA Technical Reports Server (NTRS)

    1989-01-01

    Phase 2 of a conceptual design of an integrated water treatment system to support a space colony is presented. This includes a breathable air manufacturing system, a means of drilling for underground water, and storage of water for future use. The system is to supply quality water for biological consumption, farming, residential and industrial use and the water source is assumed to be artesian or subsurface and on Mars. Design criteria and major assumptions are itemized. A general block diagram of the expected treatment system is provided. The design capacity of the system is discussed, including a summary of potential users and the level of treatment required; and, finally, various treatment technologies are described.

  7. Neutrino factory optimization for nonstandard interactions

    SciTech Connect

    Kopp, Joachim; Ota, Toshihiko; Winter, Walter

    2008-09-01

    We study the optimization of a neutrino factory with respect to nonstandard neutral current neutrino interactions, and compare the results to those obtained without nonstandard interactions. We discuss the muon energy, baselines, and oscillation channels as degrees of freedom. Our conclusions are based on both analytical calculations and on a full numerical simulation of the neutrino factory setup proposed by the international design study (IDS-NF). We consider all possible nonstandard parameters, and include their complex phases. We identify the impact of the different parameters on the golden, silver, and disappearance channels. We come to the conclusion that, even in the presence of nonstandard interactions, the performance of the neutrino factory hardly profits from a silver channel detector, unless the muon energy is significantly increased compared to the IDS-NF setup. Apart from the dispensable silver channel detector, we demonstrate that the IDS-NF setup is close to optimal even if nonstandard interactions are considered. We find that one very long baseline is a key component in the search for nonstandard interactions, in particular, for |{epsilon}{sub {mu}}{sub {tau}}{sup m}| and |{epsilon}{sub {tau}}{sub {tau}}{sup m}|.

  8. Factorial Analysis of Generalizability

    ERIC Educational Resources Information Center

    Erlich, Oded; Borich, Gary

    1978-01-01

    An overview of generalizability theory and a FORTRAN computer program for studying the generalizability of scores in a three facet, four factor design are presented. An illustrative example is presented. (Author/JKS)

  9. Linear collider approach to a B anti B factory

    SciTech Connect

    Wilson, P.B.

    1987-06-01

    In this paper we consider the basic design expression and principal design constraints for a linear collider suitable for a B anti-B factory: Energy approx. =10 GeV, luminosity 10/sup 33/-10/sup 34/ cm/sup -2/s/sup -1/, energy resolution approx. =10/sup -2/. The design of room temperature linear colliders for a B factory is discussed. In such colliders, the rf energy stored in the linac structure is thrown away after each linac pulse. Linear colliders using superconducting rf cavities are considered. Some brief conclusions are presented.

  10. The Instructional Development Factory.

    ERIC Educational Resources Information Center

    Low, D. Stewart

    The large-scale development of Time-Shared, Interactive, Computer-Controlled, Information Television (TICCIT) at Brigham Young University is described in this paper. The TICCIT project was designed to provide a market success example for computer-assisted instruction, particularly for junior or community colleges. The project incorporated a…

  11. Process optimization for the preparation of oligomycin-loaded folate-conjugated chitosan nanoparticles as a tumor-targeted drug delivery system using a two-level factorial design method

    PubMed Central

    Zu, Yuangang; Zhao, Qi; Zhao, Xiuhua; Zu, Shuchong; Meng, Li

    2011-01-01

    Oligomycin-A (Oli-A), an anticancer drug, was loaded to the folate (FA)-conjugated chitosan as a tumor-targeted drug delivery system for the purpose of overcoming the nonspecific targeting characteristics and the hydrophobicity of the compound. The two-level factorial design (2-LFD) was applied to modeling the preparation process, which was composed of five independent variables, namely FA-conjugated chitosan (FA-CS) concentration, Oli-A concentration, sodium tripolyphosphate (TPP) concentration, the mass ratio of FA-CS to TPP, and crosslinking time. The mean particle size (MPS) and the drug loading rate (DLR) of the resulting Oli-loaded FA-CS nanoparticles (FA-Oli-CSNPs) were used as response variables. The interactive effects of the five independent variables on the response variables were studied. The characteristics of the nanoparticles, such as amount of FA conjugation, drug entrapment rate (DER), DLR, surface morphology, and release kinetics properties in vitro were investigated. The FA-Oli-CSNPs with MPS of 182.6 nm, DER of 17.3%, DLR of 58.5%, and zeta potential (ZP) of 24.6 mV were obtained under optimum conditions. The amount of FA conjugation was 45.9 mg/g chitosan. The FA-Oli-CSNPs showed sustained-release characteristics for 576 hours in vitro. The results indicated that FA-Oli-CSNPs obtained as a targeted drug delivery system could be effective in the therapy of leukemia in the future. PMID:22267927

  12. From Superbeams to Neutrino Factories

    SciTech Connect

    Bross, Alan

    2010-03-30

    The Neutrino Factory, which produces an extremely intense source of flavor-tagged neutrinos from muon decays in a storage ring, arguably gives the best physics reach for CP violation, as well as virtually all parameters in the neutrino oscillation parameter space. I will briefly describe the physics capabilities of the baseline Neutrino Factory as compared to other possible future facilities (beta-beam and super-beam facilities), give an overview of the accelerator complex and describe in detail the current international R and D program.

  13. Phase system selection with fractional factorial design for purification of recombinant cyanovirin-N from a hydroponic culture medium using centrifugal partition chromatography.

    PubMed

    Grudzień, Łukasz; Madeira, Luisa; Fisher, Derek; Ma, Julian; Garrard, Ian

    2013-04-12

    Centrifugal partition chromatography (CPC) with an aqueous two-phase system (ATPS) was used to purify recombinant cyanovirin-N (CV-N) from other proteins which were co-secreted into a hydroponic plant medium in a rhizosecretion process. To achieve satisfactory protein concentration, the purification was preceded by ultrafiltration performed on a 5 kDa filter. ATPS, because of their gentle nature, were selected as the phase system for CPC. A systematic phase system selection was applied. This involved studying the effect of seven parameters of ATPS: polymer type, salt type, the polymer and salt concentration, the polymer molecular weight, pH, and presence of two additional salts; NaCl and NaClO4, which all together gave 320 combinations. design of experiment (DoE) software allowed the reduction of this number to 46. Having tested partitioning of cyanovirin-N and impurities in 46 ATPS, the three best potential phase systems generated by the programme were then tested on the CPC. Out of these three, 13/13% PEG4000 sodium phosphate, pH 3.0, proved to be most effective phase system in the purification of cyanovirin-N, judged by ELISA and SDS-PAGE analysis, as it eliminated most of the impurities from the final cyanovirin-N preparation.

  14. W.K.H. Panofsky Prize in Experimental Particle Physics: The design, construction and performance of the B Factory accelerator facilities, PEP-II and KEKB

    NASA Astrophysics Data System (ADS)

    Dorfan, Jonathan

    2016-03-01

    The discovery and elucidation of CP violation in the B-meson system presented daunting challenges for the accelerator and detector facilities. This talk discusses how these challenges were met and overcome in the electron-positron colliding-beam accelerator facilities PEP-II (at SLAC) and KEKB (at KEK). The key challenge was to produce unprecedentedly large numbers of B-mesons in a geometry that provided high-statistics, low-background samples of decays to CP eigenstates. This was realized with asymmetric collisions at the Γ(4S) at peak luminosities in excess of 3 ×1033 /sq. cm/sec. Specialized optics were developed to generate efficient, low background, multi-bunch collisions in an energy-asymmetric collision geometry. Novel technologies for the RF, vacuum and feedback systems permitted the storage of multi-amp, multi-bunch beams of electrons and positrons, thereby generating high peak luminosities. Accelerator uptimes greater than 95 percent, combined with high-intensity injection systems, ensured large integrated luminosity. Both facilities rapidly attained their design specifications and ultimately far exceeded the projected performance expectations for both peak and integrated luminosity.

  15. Particle identification at an asymmetric B Factory

    SciTech Connect

    Coyle, P.; Eigen, G.; Hitlin, D.; Oddone, P.; Ratcliff, B.; Roe, N.; Va'vra, J.; Ypsilantis, T.

    1991-09-01

    Particle identification systems are an important component of any detector at a high-luminosity, asymmetric B Factory. In particular, excellent hadron identification is required to probe CP violation in B{sup 0} decays to CP eigenstates. The particle identification systems discussed below also provide help in separating leptons from hadrons at low momenta. We begin this chapter with a discussion of the physics motivation for providing particle identification, the inherent limitations due to interactions and decays in flight, and the requirements for hermiticity and angular coverage. A special feature of an asymmetric B Factory is the resulting asymmetry in the momentum distribution as a function of polar angle; this will also be quantified and discussed. In the next section the three primary candidates, time-of-flight (TOF), energy loss (dE/dx), and Cerenkov counters, both ring-imaging and threshold, will be briefly described and evaluated. Following this, one of the candidates, a long-drift Cerenkov ring-imaging device, is described in detail to provide a reference design. Design considerations for a fast RICH are then described. A detailed discussion of aerogel threshold counter designs and associated R D conclude the chapter. 56 refs., 64 figs., 13 tabs.

  16. A factory concept for processing and manufacturing with lunar material

    NASA Technical Reports Server (NTRS)

    Driggers, G. W.

    1977-01-01

    A conceptual design for an orbital factory sized to process 1.5 million metric tons per year of raw lunar fines into 0.3 million metric tons of manufacturing materials is presented. A conservative approach involving application of present earth-based technology leads to a design devoid of new inventions. Earth based counterparts to the factory machinery were used to generate subsystem masses and lumped parameters for volume and mass estimates. The results are considered to be conservative since technologies more advanced than those assumed are presently available in many areas. Some attributes of potential space processing technologies applied to material refinement and component manufacture are discussed.

  17. Charm Factories: Present and Future

    NASA Astrophysics Data System (ADS)

    Zweber, Peter

    2009-12-01

    The next generation tau-charm factory, the third Beijing Electron Spectrometer (BESIII) at the new Beijing Electron Positron Collider (BEPCII), has begun data collection. I discuss the flavor physics reach of the BESIII charm program and conclude with a discussion on future proposed tau-charm facilities.

  18. Rural "Dropout Factories" Often Overshadowed

    ERIC Educational Resources Information Center

    Zehr, Mary Ann

    2010-01-01

    In the foothills of the Appalachian Mountains in the northwest corner of South Carolina, high schools' attempts to curb student dropouts may not match what many people picture when they hear talk of the nation's "dropout factories." Yet one-fifth of the 2,000 high schools nationwide categorized that way by researchers at Johns Hopkins University…

  19. Development of RP UPLC-TOF/MS, stability indicating method for omeprazole and its related substances by applying two level factorial design; and identification and synthesis of non-pharmacopoeial impurities.

    PubMed

    Jadhav, Sushant Bhimrao; Kumar, C Kiran; Bandichhor, Rakeshwar; Bhosale, P N

    2016-01-25

    A new UPLC-TOF/MS compatible, reverse phase-stability indicating method was developed for determination of Omeprazole (OMP) and its related substances in pharmaceutical dosage forms by implementing Design of Experiment (DoE) i.e. two level full factorial Design (2(3)+3 center points=11 experiments) to understand the Critical Method Parameters (CMP) and its relation with Critical Method Attribute (CMA); to ensure robustness of the method. The separation of eleven specified impurities including conversion product of OMP related compound F (13) and G (14) i.e. Impurity-I (1), OMP related compound-I (11) and OMP 4-chloro analog (12) was achieved in a single method on Acquity BEH shield RP18 100 × 2.1 mm, 1.7 μm column, with inlet filter (0.2 μm) using gradient elution and detector wavelength at 305 nm and validated in accordance with ICH guidelines and found to be accurate, precise, reproducible, robust and specific. The drug was found to degrade extensively in heat, humidity and acidic conditions and forms unknown degradation products during stability studies. The same method was used for LC-MS analysis to identify m/z and fragmentation of maximum unknown impurities (Non-Pharmacopoeial) i.e. Impurity-I (1), Impurity-III (3), Impurity-V (5) and Impurity-VIII (9) formed during stability studies. Based on the results, degradation pathway for the drug has been proposed and synthesis of identified impurities i.e. impurities (Impurity-I (1), Impurity-III (3), Impurity-V (5) and Impurity-VIII (9)) are discussed in detail to ensure in-depth understanding of OMP and its related impurities and optimum performance during lifetime of the product. PMID:26600119

  20. Development of RP UPLC-TOF/MS, stability indicating method for omeprazole and its related substances by applying two level factorial design; and identification and synthesis of non-pharmacopoeial impurities.

    PubMed

    Jadhav, Sushant Bhimrao; Kumar, C Kiran; Bandichhor, Rakeshwar; Bhosale, P N

    2016-01-25

    A new UPLC-TOF/MS compatible, reverse phase-stability indicating method was developed for determination of Omeprazole (OMP) and its related substances in pharmaceutical dosage forms by implementing Design of Experiment (DoE) i.e. two level full factorial Design (2(3)+3 center points=11 experiments) to understand the Critical Method Parameters (CMP) and its relation with Critical Method Attribute (CMA); to ensure robustness of the method. The separation of eleven specified impurities including conversion product of OMP related compound F (13) and G (14) i.e. Impurity-I (1), OMP related compound-I (11) and OMP 4-chloro analog (12) was achieved in a single method on Acquity BEH shield RP18 100 × 2.1 mm, 1.7 μm column, with inlet filter (0.2 μm) using gradient elution and detector wavelength at 305 nm and validated in accordance with ICH guidelines and found to be accurate, precise, reproducible, robust and specific. The drug was found to degrade extensively in heat, humidity and acidic conditions and forms unknown degradation products during stability studies. The same method was used for LC-MS analysis to identify m/z and fragmentation of maximum unknown impurities (Non-Pharmacopoeial) i.e. Impurity-I (1), Impurity-III (3), Impurity-V (5) and Impurity-VIII (9) formed during stability studies. Based on the results, degradation pathway for the drug has been proposed and synthesis of identified impurities i.e. impurities (Impurity-I (1), Impurity-III (3), Impurity-V (5) and Impurity-VIII (9)) are discussed in detail to ensure in-depth understanding of OMP and its related impurities and optimum performance during lifetime of the product.

  1. A compact and high-speed plasmonic slot waveguide coupled with photonic waveguide based 2x2 electro-optic switch

    NASA Astrophysics Data System (ADS)

    Arya, Aditya; Manivasakan, R.

    2016-02-01

    We report an electro-optic switch at 1.55 μm wavelength based on Mach-Zehnder Interferometer (MZI) in which, the MZI arms and the input-output 3-dB couplers are designed using plasmonic and photonic waveguides re- spectively. More than 90% photons are successfully converted into surface plasmons through tapering the both photonic as well as plasmonic waveguide. The plasmonic and photonic mode profiles, interaction between plas- monic and RF fields, confinement of plasmonic field in plasmonic waveguide, and trade-off between loss and confinement are thoroughly examined before the combined optical and electrical simulation of the switch. The switching voltage is less than 6 Volts, the MZI arm length is only 15 μm, the crosstalk is less than -35 dB, and the maximum switching speed is 11.55 ps. The footprint of the switch is only 290x50 μm2.

  2. Longitudinal Beam Stability in the SUPER B-FACTORY

    SciTech Connect

    Novokhatski, A.; Zobov, M.; /Frascati

    2009-07-06

    We give an overview of wake fields and impedances in a proposed Super B project, which is based on extremely low emittance beams colliding at a large angle with a crab waist transformation. Understanding the effects that wake fields have on the beam is critical for a successful machine operation. We use our combined experience from the operation of the SLAC B-factory and DA{Phi}NE {Phi}-factory to eliminate strong HOM sources and minimize the chamber impedance in the Super B design. Based on a detailed study of the wake fields in this design we have developed a quasi-Green's function for the entire ring that is used to study bunch lengthening and beam stability. In particular, we check the stability threshold using numerical solutions of the Fokker-Plank equation. We also make a comparison of numerical simulations with the bunch lengthening data in the B- factory.

  3. Kinetic models in industrial biotechnology - Improving cell factory performance.

    PubMed

    Almquist, Joachim; Cvijovic, Marija; Hatzimanikatis, Vassily; Nielsen, Jens; Jirstrand, Mats

    2014-07-01

    An increasing number of industrial bioprocesses capitalize on living cells by using them as cell factories that convert sugars into chemicals. These processes range from the production of bulk chemicals in yeasts and bacteria to the synthesis of therapeutic proteins in mammalian cell lines. One of the tools in the continuous search for improved performance of such production systems is the development and application of mathematical models. To be of value for industrial biotechnology, mathematical models should be able to assist in the rational design of cell factory properties or in the production processes in which they are utilized. Kinetic models are particularly suitable towards this end because they are capable of representing the complex biochemistry of cells in a more complete way compared to most other types of models. They can, at least in principle, be used to in detail understand, predict, and evaluate the effects of adding, removing, or modifying molecular components of a cell factory and for supporting the design of the bioreactor or fermentation process. However, several challenges still remain before kinetic modeling will reach the degree of maturity required for routine application in industry. Here we review the current status of kinetic cell factory modeling. Emphasis is on modeling methodology concepts, including model network structure, kinetic rate expressions, parameter estimation, optimization methods, identifiability analysis, model reduction, and model validation, but several applications of kinetic models for the improvement of cell factories are also discussed.

  4. From Neutrino Factory to Muon Collider

    SciTech Connect

    Geer, S.; /Fermilab

    2010-01-01

    Both Muon Colliders and Neutrino Factories require a muon source capable of producing and capturing {Omicron}(10{sup 21}) muons/year. This paper reviews the similarities and differences between Neutrino Factory and Muon Collider accelerator complexes, the ongoing R&D needed for a Muon Collider that goes beyond Neutrino Factory R&D, and some thoughts about how a Neutrino Factory on the CERN site might eventually be upgraded to a Muon Collider.

  5. From Exam Factories to Communities of Discovery

    ERIC Educational Resources Information Center

    Coffield, Frank; Williamson, Bill

    2011-01-01

    The British current model of education has turned schools into exam factories and further education colleges and universities into skills factories for British industry. In their book, "From Exam Factories to Communities of Discovery: the Democratic Route," the authors offer an alternative way of thinking and talking about education, as well as…

  6. Sequence Factorial of "g"-Gonal Numbers

    ERIC Educational Resources Information Center

    Asiru, Muniru A.

    2013-01-01

    The gamma function, which has the property to interpolate the factorial whenever the argument is an integer, is a special case (the case "g"?=?2) of the general term of the sequence factorial of "g"-gonal numbers. In relation to this special case, a formula for calculating the general term of the sequence factorial of any…

  7. On KEK B-Factory

    NASA Astrophysics Data System (ADS)

    Sugawara, H.

    2009-07-01

    There are two principles which the management of a research institute like KEK must respect when dealing with such big project as B-Factory. One is the scientific merit of the project and the other is the organizational consideration which includes financial, human, technical and historical elements. Ideally, the two principles are to be fully taken into account. But, in many cases, one or the other is only partially fulfilled due to unavoidable circumstances. The lack of flexibility to respond to all possible situations is more dangerous and may lead to a disaster as in the case of SSC. I will describe the process which lead to the successful construction, operation and physics presentations of KEK B-Factory following faithfully the official records.

  8. Results from the B Factories

    SciTech Connect

    Bevan, A.; /Queen Mary, U. of London

    2009-01-08

    These proceedings are based on lectures given at the Helmholtz International Summer School Heavy Quark Physics at the Bogoliubov Laboratory of Theoretical Physics, Dubna, Russia, during August 2008. I review the current status of CP violation in B meson decays from the B factories. These results can be used, along with measurements of the sides of the Unitarity Triangle, to test the CKM mechanism. In addition I discuss experimental studies of B decays to final states with 'spin-one' particles.

  9. NEUTRINO FACTORY AND BETA BEAM EXPERIMENTS AND DEVELOPMENT.

    SciTech Connect

    ALBRIGHT, C.; BERG, J.S.; FERNOW, R.; GALLARDO, J.; KAHN, S.; KIRK, H.; ET AL.

    2004-09-21

    The long-term prospects for fully exploring three-flavor mixing in the neutrino sector depend upon an ongoing and increased investment in the appropriate accelerator R&D. Two new concepts have been proposed that would revolutionize neutrino experiments, namely the Neutrino Factory and the Beta Beam facility. These new facilities would dramatically improve our ability to test the three-flavor mixing framework, measure CP violation in the lepton sector, and perhaps determine the neutrino mass hierarchy, and, if necessary, probe extremely small values of the mixing angle {theta}{sub 13}. The stunning sensitivity that could be achieved with a Neutrino Factory is described, together with our present understanding of the corresponding sensitivity that might be achieved with a Beta Beam facility. In the Beta Beam case, additional study is required to better understand the optimum Beta Beam energy, and the achievable sensitivity. Neither a Neutrino Factory nor a Beta Beam facility could be built without significant R&D. An impressive Neutrino Factory R&D effort has been ongoing in the U.S. and elsewhere over the last few years and significant progress has been made towards optimizing the design, developing and testing the required accelerator components, and significantly reducing the cost. The recent progress is described here. There has been no corresponding activity in the U.S. on Beta Beam facility design and, given the very limited resources, there is little prospect of starting a significant U.S. Beta Beam R&D effort in the near future. However, the Beta Beam concept is interesting, and progress on its development in Europe should be followed. The Neutrino Factory R&D program has reached a critical stage in which support is required for two crucial international experiments and a third-generation international design study. If this support is forthcoming, a Neutrino Factory could be added to the Neutrino Community's road map in about a decade.

  10. Replicating systems concepts: Self-replicating lunar factory and demonstration

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Automation of lunar mining and manufacturing facility maintenance and repair is addressed. Designing the factory as an automated, multiproduct, remotely controlled, reprogrammable Lunar Manufacturing Facility capable of constructing duplicates of itself which would themselves be capable of further replication is proposed.

  11. The Use of Factorial Forecasting to Predict Public Response

    ERIC Educational Resources Information Center

    Weiss, David J.

    2012-01-01

    Policies that call for members of the public to change their behavior fail if people don't change; predictions of whether the requisite changes will take place are needed prior to implementation. I propose to solve the prediction problem with Factorial Forecasting, a version of functional measurement methodology that employs group designs. Aspects…

  12. Neutrino Factory and Muon Collider Collaboration R and D Program

    SciTech Connect

    Zisman, M.S.

    2000-07-01

    The Neutrino Factory and Muon Collider Collaboration (MC) comprises some 140 scientists and engineers located at U.S. National Laboratories and Universities, and at a number of non-U.S. research institutions. In the past year, the MC R and D program has shifted its focus mainly toward the design issues related to the development of a Neutrino Factory based on a muon storage ring. In this paper the status of the various R and D activities is described, and future plans are outlined.

  13. A Survey of Small Factories*

    PubMed Central

    Jefferys, Margot; Wood, C. H.

    1960-01-01

    This survey was undertaken by a group of doctors, nurses, and lecturers in the Department of Public Health of the London School of Hygiene and Tropical Medicine as part of the teaching programme for the Diploma in Public Health. Fifty small factories in an area of a metropolitan borough were invited to answer questions concerning their industrial processes, their labour force, their premises, their first-aid provision, and the visits they received from officials of local and central government. Forty-eight of these factories responded and observations were made by teams of three recording independently of each other in 45. A variety of industries was represented in these 48 firms, half of which employed less than 10 workers. The working environment, in respect of sanitary arrangements, cleanliness and tidiness, lighting on stairs and passage ways, was considered to be unsatisfactory in many firms. Some instances of inadequate safeguards of machines were seen. The accident rate was found to be rather less than the computed national rate for manufacturing industry in 1956. First-aid equipment and workers were also considered to be deficient in a number of instances. In case of accident and for the treatment of minor ailments most firms made use of a local casualty and out-patient department of a general hospital. This service was considered quite adequate. Many firms had not been visited by the Factory Inspector or his deputy during the previous year. Rather more had received visits from the local authority health inspectors. Many firms expressed confusion about the duties and functions of their various official visitors. The conclusions drawn from this limited enquiry were that the working conditions in small factories are often unsatisfactory; that in areas such as the one surveyed it is unrealistic to think in terms of development of an industrial health service similar to those operating in Slough and Harlow; and that the greatest impact on environmental

  14. Gearing up to the factory of the future

    NASA Astrophysics Data System (ADS)

    Godfrey, D. E.

    1985-01-01

    The features of factories and manufacturing techniques and tools of the near future are discussed. The spur to incorporate new technologies on the factory floor will originate in management, who must guide the interfacing of computer-enhanced equipment with traditional manpower, materials and machines. Electronic control with responsiveness and flexibility will be the key concept in an integrated approach to processing materials. Microprocessor controlled laser and fluid cutters add accuracy to cutting operations. Unattended operation will become feasible when automated inspection is added to a work station through developments in robot vision. Optimum shop management will be achieved through AI programming of parts manufacturing, optimized work flows, and cost accounting. The automation enhancements will allow designers to affect directly parts being produced on the factory floor.

  15. Agreement among 2 x 2 Agreement Indices.

    ERIC Educational Resources Information Center

    Conger, Anthony J.; Ward, David G.

    1984-01-01

    Sixteen measures of reliability for two-category nominal scales are compared. Upon correcting for chance agreement, there are only five distinct indices: Fleiss's modification of A-sub-1, the phi coefficient, Cohen's kappa, and two intraclass coefficients. Recommendations for choosing an agreement index are made based on definitions, magnitude,…

  16. Black holes as antimatter factories

    NASA Astrophysics Data System (ADS)

    Bambi, Cosimo; Dolgov, Alexander D.; Petrov, Alexey A.

    2009-09-01

    We consider accretion of matter onto a low mass black hole surrounded by ionized medium. We show that, because of the higher mobility of protons than electrons, the black hole would acquire positive electric charge. If the black hole's mass is about or below 1020 g, the electric field at the horizon can reach the critical value which leads to vacuum instability and electron-positron pair production by the Schwinger mechanism. Since the positrons are ejected by the emergent electric field, while electrons are back-captured, the black hole operates as an antimatter factory which effectively converts protons into positrons.

  17. A plant factory for moth pheromone production.

    PubMed

    Ding, Bao-Jian; Hofvander, Per; Wang, Hong-Lei; Durrett, Timothy P; Stymne, Sten; Löfstedt, Christer

    2014-02-25

    Moths depend on pheromone communication for mate finding and synthetic pheromones are used for monitoring or disruption of pheromone communication in pest insects. Here we produce moth sex pheromone, using Nicotiana benthamiana as a plant factory, by transient expression of up to four genes coding for consecutive biosynthetic steps. We specifically produce multicomponent sex pheromones for two species. The fatty alcohol fractions from the genetically modified plants are acetylated to mimic the respective sex pheromones of the small ermine moths Yponomeuta evonymella and Y. padella. These mixtures are very efficient and specific for trapping of male moths, matching the activity of conventionally produced pheromones. Our long-term vision is to design tailor-made production of any moth pheromone component in genetically modified plants. Such semisynthetic preparation of sex pheromones is a novel and cost-effective way of producing moderate to large quantities of pheromones with high purity and a minimum of hazardous waste.

  18. KEKB and PEP-II B Factories

    SciTech Connect

    Seeman, J.T.

    1997-01-01

    Two asymmetric B-Factories KEKB at KEK and PEP-II at SLAC are under construction, designed to study CP violation in the b-quark sector with a center of mass energy of 10.58 GeV. These two new accelerators are high luminosity two-ring two-energy e{sup +}e{sup {minus}} colliders with one interaction point. There are many challenging accelerator physics and engineering issues associated with the high beam currents and high luminosities of these rings. The chosen solutions to these issues and the general parameters of the two rings are described in detail side-by-side. KEKB and PEP-II are well into the installation phase and are both scheduled to be completed in 1998. The particle physics programs are scheduled to start in 1999.

  19. A plant factory for moth pheromone production

    PubMed Central

    Ding, Bao-Jian; Hofvander, Per; Wang, Hong-Lei; Durrett, Timothy P.; Stymne, Sten; Löfstedt, Christer

    2014-01-01

    Moths depend on pheromone communication for mate finding and synthetic pheromones are used for monitoring or disruption of pheromone communication in pest insects. Here we produce moth sex pheromone, using Nicotiana benthamiana as a plant factory, by transient expression of up to four genes coding for consecutive biosynthetic steps. We specifically produce multicomponent sex pheromones for two species. The fatty alcohol fractions from the genetically modified plants are acetylated to mimic the respective sex pheromones of the small ermine moths Yponomeuta evonymella and Y. padella. These mixtures are very efficient and specific for trapping of male moths, matching the activity of conventionally produced pheromones. Our long-term vision is to design tailor-made production of any moth pheromone component in genetically modified plants. Such semisynthetic preparation of sex pheromones is a novel and cost-effective way of producing moderate to large quantities of pheromones with high purity and a minimum of hazardous waste. PMID:24569486

  20. Synthesis, crystal structure and characterization of new 12H hexagonal perovskite-related oxides Ba 6M2Na 2X2O 17 ( M=Ru, Nb, Ta, Sb; X=V, Cr, Mn, P, As)

    NASA Astrophysics Data System (ADS)

    Quarez, Eric; Abraham, Francis; Mentré, Olivier

    2003-11-01

    The new Ba 6Ru 2Na 2X2O 17 ( X=V, Mn) compounds have been prepared by electrosynthesis in molten NaOH and their crystal structures have been refined from single crystals X-ray diffraction, space group P6 3/ mmc, Z=2, for X=V: a =5.8506(1) Å, c =29.6241(4) Å, R1=4.76%, for X=Mn : a =5.8323(1) Å, c =29.5299(3) Å, R1=3.48%. The crystal structure is a 12H-type perovskite with a ( c' cchcc) 2 stacking sequence of [BaO 3] c, [BaO 3] h and [BaO 2] c' layers. The tridimensional edifice is formed by blocks of Ru 2O 9 dimers that share corners with NaO 6 octahedra. These blocks sandwich double sheets of X5+O 4 tetrahedra. Several isotypic Ba 6M5+2Na 2X5+2O 17 materials ( X=V, Cr, Mn, P, As) and ( M=Ru, Nb, Ta, Sb) have been prepared by solid state reaction and characterized by Rietveld analysis. The magnetic and electric properties have been investigated and show besides the Ru 5+2O 9 typical intradimer antiferromagnetic couplings, discrepancies of both χ and ρ versus T at 50 and 100 K for Ba 6Ru 2Na 2X2O 17 ( X=V, As). In this work, a review of the identified Ru-hexagonal perovskite materials is also reported in order to overview the wide variety of possibilities in the field of new compounds synthesis.

  1. Influences of the substituents on the M-M bonding in Cp4Al4 and Cp2M2X2 (M = B, Al, Ga; Cp = C5H5, X = halogen).

    PubMed

    Lu, Feifei; Li, Xiaoyan; Sun, Zheng; Zeng, Yanli; Meng, Lingpeng

    2015-08-21

    Although the geometries of CpAl4 (Cp* = C5Me5) and Cp4Al4 (Cp = C5H5) are similar, CpAl4 is more stable than Cp4Al4. CpAl2I2 is the first complex involving an Al(ii)-Al(ii) bond to be supported by Cp-type ligands. In this work, the stability of CpAl4 and Cp4Al4 (Cp = C5H5), the nature of M-M bonding in Cp2M2X2 (M = B, Al, and Ga), and the influences of the X atom on the M-M bonds have been analyzed and compared within the framework of the atoms in molecules (AIM) theory, electron localization function (ELF), energy decomposition analysis (EDA), and natural bond orbital (NBO) analysis. The calculated results show that CpAl4 is more stable than Cp4Al4 because of HH interactions between the methyl groups on the same and different Cp rings and not because of the Al-Al bonds. In Cp2M2X2, the B-B bond is stronger than the Al-Al and Ga-Ga bonds. The B-B bond is most consistent with covalent bonding, whereas the Al-Al and Ga-Ga bonds are more consistent with metallic bonding. The strengths of the B-B bond increase in the sequence X = F, Cl, Br, and I, whereas the Al-Al and Ga-Ga bonds decrease in the sequence X = F, Cl, Br, and I. The different change tendencies arise from the different M-M bonds and the orbital interactions between atoms X and M.

  2. Naval Aircraft Factory (Curtiss) H-16

    NASA Technical Reports Server (NTRS)

    1929-01-01

    Naval Aircraft Factory (Curtiss) H-16: The Naval Aircraft Factory H-16 flying boat, seen here on a beaching dolly on the Langley seaplane ramp, was one of 150 built by the Naval Aircraft Factory in Philadelphia, Pennsylvania. Most H-16s built were made by Curtiss, so the type is more readily known under that name. The NACA performed hull pressure distribution tests at Langley during 1929.

  3. Agile manufacturing: The factory of the future

    NASA Technical Reports Server (NTRS)

    Loibl, Joseph M.; Bossieux, Terry A.

    1994-01-01

    The factory of the future will require an operating methodology which effectively utilizes all of the elements of product design, manufacturing and delivery. The process must respond rapidly to changes in product demand, product mix, design changes or changes in the raw materials. To achieve agility in a manufacturing operation, the design and development of the manufacturing processes must focus on customer satisfaction. Achieving greatest results requires that the manufacturing process be considered from product concept through sales. This provides the best opportunity to build a quality product for the customer at a reasonable rate. The primary elements of a manufacturing system include people, equipment, materials, methods and the environment. The most significant and most agile element in any process is the human resource. Only with a highly trained, knowledgeable work force can the proper methods be applied to efficiently process materials with machinery which is predictable, reliable and flexible. This paper discusses the affect of each element on the development of agile manufacturing systems.

  4. Optimization of water treatment methods for the purification of peat extraction derived runoff: Evaluation of chemical treatment response to variations in incoming water quality using a 2k factorial test design

    NASA Astrophysics Data System (ADS)

    Heiderscheidt, Elisangela; Ronkanen, Anna-Kaisa; Klöve, Björn

    2013-04-01

    environmental impacts related to this treatment method. The influence of variations in water quality parameters was accessed using a 2k factorial test design and a well-known chemical purification pilot test procedure (jar test). The k factors or parameters evaluated were: organic matter as chemical oxygen demand (COD 20mg/l and 80mg/l), suspended solids (SS 10mg/l and 60 mg/l), applied coagulant dosage (ferric sulphate 35mg/l and 100mg/l) as well as pH (4.5 and 7.0). Water samples were collected from different peat extraction sites and suitable samples were manipulated using techniques such as centrifugation, dilution and acid or base addition to produce samples with the combinations of high and low concentrations presented. The complete statistical analysis of obtained results will include evaluation of variability using the univariate repeated measures ANOVA as well as the multivariate repeated measures ANOVA methods. Preliminary results of the univariate analyses shows that the interaction between the concentration of a particular substance (COD, SS and pH) and the dosage applied impose significant higher influence on the overall purification efficiency than the substance concentration and applied dosage as individual factors.

  5. Douglas DT-2 (Naval Aircraft Factory

    NASA Technical Reports Server (NTRS)

    1923-01-01

    Douglas DT-2 (Naval Aircraft Factory): This example of the Douglas DT-2 torpedo plane, which flew as 'NACA 11,' was built in Philadelphia, Pennsylvania by the Naval Aircraft Factory. Langley's NACA staff studied the take-off characteristics of a twin-float seaplane with this aircraft.

  6. A Tau-Charm Factory at CEBAF

    SciTech Connect

    Seth, K.K.

    1994-04-01

    It is proposed that a Tau Charm Factory represents a natural extension of CEBAF into higher energy domains. The exciting nature of the physics of charm quarks and tau leptons is briefly reviewed and it is suggested that the concept of a linac-ring collider as a Tau Charm Factory at CEBAF should be seriously studied.

  7. Factorial Validity of Student Ratings of Instruction

    ERIC Educational Resources Information Center

    Renaud, Robert D.; Murray, Harry G.

    2005-01-01

    This study tested the Systematic Distortion Hypothesis by examining the factorial validity of student ratings of university teaching. Factorial validity is defined as the degree to which covariance among judged traits resembles the actual or true covariation of observable behaviors underlying these traits. Although many studies have examined the…

  8. Options for Production Staging for a Low Energy Neutrino Factory

    SciTech Connect

    Berg J. S.

    2011-10-26

    A low energy neutrino factory (LENF) is defined, for the purpose of this report, to accelerate a muon beam to a total energy in the range of 10-14 GeV, and store it in a decay ring directing a resulting neutrino beam to a detector 2200-2300 km distant. The machine should be ultimately capable of producing 10{sup 21} decays toward that detector per year of 10{sup 7} s. We consider such a neutrino factory to be the accelerator defined in the Interim Design Report (IDR) of the International Design Study for the Neutrino Factory (IDS-NF), modified to remove the final stage of acceleration, possibly modifying the remaining acceleration stages to adjust the final energy, and replacing the decay ring with one designed for the lower energy and shorter baseline. We discuss modifications to that design which would reduce the cost of the machine at the price of a reduction in neutrino production, down to as low as 10{sup 20} decays per year. These modifications will not preclude eventually upgrading the machine to the full production of 10{sup 21} decays per year. The eventual cost of a machine which achieves the full production through a series of lower-production stages should not exceed the cost of a machine which is immediately capable of the full production by more than a small fraction of the cost difference between the full production machine and the lowest production stage.

  9. Implementation of China`s three synchronizations policy: Case studies of wastewater treatment measures at new and renovated factories

    SciTech Connect

    Sinkule, B.J.

    1994-03-01

    The Three Synchronizations Policy requires that the design, construction, and operation of a new factory, or an existing factory that expands or changes production processes, be synchronized with the design, construction and operation of appropriate waste treatment facilities. Under this policy, when a new factory is designed, wastewater treatment facilities must be included as part of the overall factory design: when the factory is constructed, the wastewater treatment facilities must be constructed along with construction of the production facilities; and finally, when the factory begins to operate, the waste treatment facilities must begin operation as well. This research includes case studies of wastewater treatment measures at sixteen factories in the Pearl River Delta Region of China. Implementation of the Three Synchronizations Policy is examined in detail for two of the factories: Fengfu Weaving and Dyeing Plant and Zhongguan Printing and Dyeing Plant. The results of this research suggest that the Three Synchronizations Policy has been an effective means of forcing new and renovated factories to comply with wastewater discharge standards, mainly because the Three Synchronizations Policy gives environmental protection bureaus authority to regulate at each step of a new industrial facility`s development. In practice, this authority has been exercised through formalizing the {open_quotes}synchronizations{close_quotes} into a management system with specific regulatory requirements, each of which requires EPB approval. EPBs ran stall operation by withholding its approval of certification of a factory`s wastewater treatment facilities; EPBs also use fines and limited time treatment orders to enforce the Three Synchronizations Policy. The research results demonstrate that the Three Synchronizations Policy was more important than the Pollutant Discharge Fee Program in motivating existing factories to build wastewater treatment facilities.

  10. Factorial invariance in multilevel confirmatory factor analysis.

    PubMed

    Ryu, Ehri

    2014-02-01

    This paper presents a procedure to test factorial invariance in multilevel confirmatory factor analysis. When the group membership is at level 2, multilevel factorial invariance can be tested by a simple extension of the standard procedure. However level-1 group membership raises problems which cannot be appropriately handled by the standard procedure, because the dependency between members of different level-1 groups is not appropriately taken into account. The procedure presented in this article provides a solution to this problem. This paper also shows Muthén's maximum likelihood (MUML) estimation for testing multilevel factorial invariance across level-1 groups as a viable alternative to maximum likelihood estimation. Testing multilevel factorial invariance across level-2 groups and testing multilevel factorial invariance across level-1 groups are illustrated using empirical examples. SAS macro and Mplus syntax are provided.

  11. The Operator Guide: An Ambient Persuasive Interface in the Factory

    NASA Astrophysics Data System (ADS)

    Meschtscherjakov, Alexander; Reitberger, Wolfgang; Pöhr, Florian; Tscheligi, Manfred

    In this paper we introduce the context of a semiconductor factory as a promising area for the application of innovative interaction approaches. In order to increase efficiency ambient persuasive interfaces, which influence the operators' behaviour to perform in an optimized way, could constitute a potential strategy. We present insights gained from qualitative studies conducted in a specific semiconductor factory and provide a description of typical work processes and already deployed interfaces in this context. These findings informed the design of a prototype of an ambient persuasive interface within this realm - the "Operator Guide". Its overall aim is to improve work efficiency, while still maintaining a minimal error rate. We provide a detailed description of the Operator Guide along with an outlook of the next steps within a user-centered design approach.

  12. R&D Toward Neutrino Factories and Muon Colliders

    SciTech Connect

    Zisman, Michael S.

    2003-06-24

    R&D aimed at the production, acceleration, and storage of intense muon beams is under way in the U.S., in Europe, and in Japan. Considerable progress has been made in the past few years toward the design of a ''Neutrino Factory'' in which a beam of 20-50 GeV mu- or mu+ is stored. Decay neutrinos from the beam illuminate a detector located roughly 3000 km from the ring. Here, we briefly describe the ingredients of a Neutrino Factory and then discuss the current R&D program and its results. A key concept in the design is ''ionization cooling,'' a process whereby the muon emittance is reduced by repeated interactions with an absorber material followed by reacceleration with high-gradient rf cavities. Plans to test this concept in the Muon Ionization Cooling Experiment (MICE) are well along and are described briefly.

  13. Feedback implementation options and issues for B factory accelerators

    SciTech Connect

    Fox, J.D.; Briggs, D.; Eisen, N.; Hindi, H.; Hosseini, W.; Oxoby, G.; Linscott, I.; Coiro, O.; Ghigo, A.; Serio, M.; Lambertson, G.; Voelker, F.

    1992-09-01

    The proposed B factory accelerator facilities will require active feedback systems to control multibunch instabilities. These feedback systems must operate in machines with thousands of circulating bunches and with short (2--4 ns) interbunch intervals. The functional requirements for transverse (betatron) and longitudinal (synchrotron) feedback systems are presented. Several possible implementation options are discussed and system requirements developed. Conceptual designs are presented for the PEP II transverse and longitudinal feedback systems.

  14. New insights into the comprehension of the magnetic properties of dinuclear Mn(III) compounds with the general formula [{MnL(NN)}2(μ-O)(μ-n-RC6H4COO)2]X2.

    PubMed

    Escriche-Tur, Luis; Font-Bardia, Mercè; Albela, Belén; Corbella, Montserrat

    2016-07-19

    Five new dinuclear Mn(iii) compounds with benzoato derivative bridges [{Mn(bpy)L}2(μ-O)(μ-n-RC6H4COO)2]X2 (n-R = 3-MeO, 4-MeO and 4-tBu, X = NO3(-) and ClO4(-)) were synthesised and characterised. According to X-ray diffraction, the X anions tend to be coordinated to the Mn ions and may occupy the place of the monodentate ligand L. Two structural isomers that only differ in one of their monodentate ligands have been obtained with the 3-MeOC6H4COO(-) bridges. For all compounds, the Mn(iii) ions display elongated octahedra with a pronounced rhombic distortion. To quantify these distortions separately, the elongation and rhombicity parameters Δ and ρ have been defined. The magnetic study shows a good relationship between the distortion of the coordination polyhedra and the zero field splitting parameters (DMn and EMn). From the magnetic data of a powder sample, it is possible to determine the sign and magnitude of DMn for ferromagnetic systems or weak antiferromagnetic systems with DMn < 0. For this kind of dinuclear compound, the R group at the meta position, the rhombic distortion of the octahedra, and large torsion angles between the Jahn-Teller axes lead to ferromagnetic interactions.

  15. New insights into the comprehension of the magnetic properties of dinuclear Mn(III) compounds with the general formula [{MnL(NN)}2(μ-O)(μ-n-RC6H4COO)2]X2.

    PubMed

    Escriche-Tur, Luis; Font-Bardia, Mercè; Albela, Belén; Corbella, Montserrat

    2016-07-19

    Five new dinuclear Mn(iii) compounds with benzoato derivative bridges [{Mn(bpy)L}2(μ-O)(μ-n-RC6H4COO)2]X2 (n-R = 3-MeO, 4-MeO and 4-tBu, X = NO3(-) and ClO4(-)) were synthesised and characterised. According to X-ray diffraction, the X anions tend to be coordinated to the Mn ions and may occupy the place of the monodentate ligand L. Two structural isomers that only differ in one of their monodentate ligands have been obtained with the 3-MeOC6H4COO(-) bridges. For all compounds, the Mn(iii) ions display elongated octahedra with a pronounced rhombic distortion. To quantify these distortions separately, the elongation and rhombicity parameters Δ and ρ have been defined. The magnetic study shows a good relationship between the distortion of the coordination polyhedra and the zero field splitting parameters (DMn and EMn). From the magnetic data of a powder sample, it is possible to determine the sign and magnitude of DMn for ferromagnetic systems or weak antiferromagnetic systems with DMn < 0. For this kind of dinuclear compound, the R group at the meta position, the rhombic distortion of the octahedra, and large torsion angles between the Jahn-Teller axes lead to ferromagnetic interactions. PMID:27295557

  16. Origin of the X1X1X2X2/X1X2Y sex chromosome system of Harttia punctata (Siluriformes, Loricariidae) inferred from chromosome painting and FISH with ribosomal DNA markers.

    PubMed

    Blanco, Daniel Rodrigues; Vicari, Marcelo Ricardo; Lui, Roberto Laridondo; Artoni, Roberto Ferreira; de Almeida, Mara Cristina; Traldi, Josiane Baccarin; Margarido, Vladimir Pavan; Moreira-Filho, Orlando

    2014-04-01

    Harttia is a genus in the subfamily Loricariinae that accommodates fishes popularly known as armored catfishes. They show extensive karyotypic diversity regarding interspecific numerical/structural variation of the karyotypes, with the presence of the XX/XY1Y2 multiple sex chromosome system, as found in H. carvalhoi. In this context, this study aimed to characterize Harttia punctata chromosomally, for the first time, and to infer the rearrangements that originated the X1X1X2X2/X1X2Y multiple sex chromosome system present in this species. The data obtained in this study, with classical (Giemsa, C-banding and AgNORs) and molecular methodologies (fluorescence in situ hybridization) and chromosome microdissection, indicated that a translocation between distinct acrocentric chromosomes bearing rRNA genes, accompanied by deletions in both chromosomes, might have originated the neo-Y chromosome in this species. The data also suggest that the multiple sex chromosome systems present in H. carvalhoi and H. punctata had an independent origin, evidencing the recurrence of chromosome alterations in species from this genus.

  17. Chromosomal distribution of two multigene families and the unusual occurrence of an X1X1X2X2/X1X2Y sex chromosome system in the dolphinfish (Coryphaenidae): an evolutionary perspective.

    PubMed

    Soares, R X; Bertollo, L A C; Cioffi, M B; Costa, G W W F; F Molina, W

    2014-01-01

    Dolphinfishes (Coryphaenidae) are pelagic predators distributed throughout all tropical and subtropical oceans and are very important for commercial, traditional, and sport fishing. This small family contains the Coryphaena hippurus and Coryphaena equiselis species whose chromosomal aspects remain unknown, despite recent advances in cytogenetic data assimilation for Perciformes. In this study, both species were cytogenetically analyzed using different staining techniques (C-, Ag-, and CMA3 banding) and fluorescence in situ hybridization, to detect 18S rDNA and 5S rDNA. C. hippurus females exhibit 2n = 48 chromosomes, with 2m+4sm+42a (NF = 54). In C. equiselis, where both sexes could be analyzed, females displayed 2n = 48 chromosomes (2m+6sm+40a) and males exhibited 2n = 47 chromosomes (3m+6sm+38a) (NF = 56), indicating the presence of X1X1X2X2/X1X2Y multiple sex chromosomes. Sex-chromosome systems are rare in Perciformes, with this study demonstrating the first occurrence in a marine pelagic species. It remains unknown as to whether this system extends to other populations; however, these data are important with respect to evolutionary, phylogenetic, and speciation issues, as well as for elucidating the genesis of this unique sex system. PMID:24782001

  18. 1. VIEW TO SOUTHEAST (NORTHWEST CORNER OF EDIBLE FATS FACTORY) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW TO SOUTHEAST (NORTHWEST CORNER OF EDIBLE FATS FACTORY) - Wilson's Oil House, Lard Refinery, & Edible Fats Factory, Edible Fats Factory, 2801 Southwest Fifteenth Street, Oklahoma City, Oklahoma County, OK

  19. 3. VIEW TO SOUTHWEST (NORTHEAST CORNER OF EDIBLE FATS FACTORY) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW TO SOUTHWEST (NORTHEAST CORNER OF EDIBLE FATS FACTORY) - Wilson's Oil House, Lard Refinery, & Edible Fats Factory, Edible Fats Factory, 2801 Southwest Fifteenth Street, Oklahoma City, Oklahoma County, OK

  20. 4. SOUTHEAST CORNER OF EDIBLE FATS FACTORY (CONNECTING BUILDING ON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. SOUTHEAST CORNER OF EDIBLE FATS FACTORY (CONNECTING BUILDING ON THE LEFT) - Wilson's Oil House, Lard Refinery, & Edible Fats Factory, Edible Fats Factory, 2801 Southwest Fifteenth Street, Oklahoma City, Oklahoma County, OK

  1. 6. FACTORY BUILDING, WITH FINISHED PRODUCT WAREHOUSE IN RIGHT BACKGROUND. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. FACTORY BUILDING, WITH FINISHED PRODUCT WAREHOUSE IN RIGHT BACKGROUND. VIEW TO NORTHWEST. - Commercial & Industrial Buildings, Maizewood Insulation Company Factory, 275 Salina Street, Dubuque, Dubuque County, IA

  2. Verbal and Nonverbal Communication of Factory Workers

    ERIC Educational Resources Information Center

    Tway, Patricia

    1976-01-01

    Examines the verbal and nonverbal behavior patterns associated with two speech styles, one formal and the other informal, among factory workers. Available from: Mouton Publishers, Box 482, the Hague, Netherlands. (AM)

  3. Neutrino Factory Targets and the MICE Beam

    SciTech Connect

    Walaron, Kenneth Andrew

    2007-01-01

    The future of particle physics in the next 30 years must include detailed study of neutrinos. The first proof of physics beyond the Standard Model of particle physics is evident in results from recent neutrino experiments which imply that neutrinos have mass and flavour mixing. The Neutrino Factory is the leading contender to measure precisely the neutrino mixing parameters to probe beyond the Standard Model physics. Significantly, one must look to measure the mixing angle θ13 and investigate the possibility of leptonic CP violation. If found this may provide a key insight into the origins of the matter/anti- matter asymmetry seen in the universe, through the mechanism of leptogenesis. The Neutrino Factory will be a large international multi-billion dollar experiment combining novel new accelerator and long-baseline detector technology. Arguably the most important and costly features of this facility are the proton driver and cooling channel. This thesis will present simulation work focused on determining the optimal proton driver energy to maximise pion production and also simulation of the transport of this pion °ux through some candidate transport lattices. Bench-marking of pion cross- sections calculated by MARS and GEANT4 codes to measured data from the HARP experiment is also presented. The cooling channel aims to reduce the phase-space volume of the decayed muon beam to a level that can be e±ciently injected into the accelerator system. The Muon Ionisation Cooling Experiment (MICE) hosted by the Rutherford Appleton laboratory, UK is a proof-of-principle experiment aimed at measuring ionisation cooling. The experiment will run parasitically to the ISIS accelerator and will produce muons from pion decay. The MICE beamline provides muon beams of variable emittance and momentum to the MICE experiment to enable measurement of cooling over a wide range of beam conditions. Simulation work in the design of this beamline is presented in this thesis as

  4. The Physics of the B Factories

    DOE PAGES

    Bevan, A. J.

    2014-11-19

    This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C.

  5. Riken RI Beam Factory, Harvest Time

    NASA Astrophysics Data System (ADS)

    En'yo, H.

    2015-06-01

    At RIKEN RI Beam Factory (RIBF), having all the experimental facilities in place, the uranium-beam intensity recorded 25pnA in 2014. With use of this powerful beam many experiments are begin performed by variety of researchers from all over the world, producing a lot of new data which were just a dream in several years ago. Recent status of RIKEN RI Beam Factory (RIBF) is presented with future prospects in science and an accelerator plan.

  6. Interaction region considerations for a B-factory

    SciTech Connect

    DeStaebler, H.

    1990-07-01

    The goal of the project is to observe CP violation in the {bar B}B system. This machine is supposed to be a factory for high energy physics, not an R D project for accelerator physics. There are a number of interrelated design issues arising from the different desires of the detector and the machine, some of which are listed in this paper. A number of background and beampipe issues are mentioned. The emphasis is on calculations. Any satisfactory design will combine measurements on existing machines with calculations pertaining to the measurement conditions as well as to the proposed machine. 57 refs.

  7. Expression and Perception of Emotion: Race and Sex.

    ERIC Educational Resources Information Center

    Gitter, A. George; Black, Harvey

    A 2 x 2 x 2 x 2 factorial design was utilized to investigate the effects of race of expressor (black and white), sex of expressor, race of perceiver and sex of perceiver on perception of emotion (POE). Perception of seven emotions (anger, happiness, surprise, fear, disgust, pain, and sadness) was analyzed in terms of three dependent variables: (1)…

  8. Metabolic modelling in the development of cell factories by synthetic biology

    PubMed Central

    Jouhten, Paula

    2012-01-01

    Cell factories are commonly microbial organisms utilized for bioconversion of renewable resources to bulk or high value chemicals. Introduction of novel production pathways in chassis strains is the core of the development of cell factories by synthetic biology. Synthetic biology aims to create novel biological functions and systems not found in nature by combining biology with engineering. The workflow of the development of novel cell factories with synthetic biology is ideally linear which will be attainable with the quantitative engineering approach, high-quality predictive models, and libraries of well-characterized parts. Different types of metabolic models, mathematical representations of metabolism and its components, enzymes and metabolites, are useful in particular phases of the synthetic biology workflow. In this minireview, the role of metabolic modelling in synthetic biology will be discussed with a review of current status of compatible methods and models for the in silico design and quantitative evaluation of a cell factory. PMID:24688669

  9. Correlated ab initio investigations on the intermolecular and intramolecular potential energy surfaces in the ground electronic state of the O2-(X2Πg)-HF(X1Σ+) complex

    NASA Astrophysics Data System (ADS)

    Fawzy, Wafaa M.; Elsayed, Mahmoud; Zhang, Yuchen

    2013-01-01

    This work reports the first highly correlated ab initio study of the intermolecular and intramolecular potential energy surfaces in the ground electronic state of the O_2^ - (X{}^2Π _g) - HF(X{}^1Σ^+) complex. Accurate electronic structure calculations were performed using the coupled cluster method including single and double excitations with addition of the perturbative triples correction [CCSD(T)] with the Dunning's correlation consistent basis sets aug-cc-pVnZ, n = 2-5. Also, the explicitly correlated CCSD(T)-F12a level of theory was employed with the AVnZ basis as well as the Peterson and co-workers VnZ-F12 basis sets with n = 2 and 3. Results of all levels of calculations predicted two equivalent minimum energy structures of planar geometry and Cs symmetry along the A″ surface of the complex, whereas the A' surface is repulsive. Values of the geometrical parameters and the counterpoise corrected dissociation energies (Cp-De) that were calculated using the CCSD(T)-F12a/VnZ-F12 level of theory are in excellent agreement with those obtained from the CCSD(T)/aug-cc-pV5Z calculations. The minimum energy structure is characterized by a very short hydrogen bond of length of 1.328 Å, with elongation of the HF bond distance in the complex by 0.133 Å, and De value of 32.313 Kcal/mol. Mulliken atomic charges showed that 65% of the negative charge is localized on the hydrogen bonded end of the superoxide radical and the HF unit becomes considerably polarized in the complex. These results suggest that the hydrogen bond is an incipient ionic bond. Exploration of the potential energy surface confirmed the identified minimum and provided support for vibrationally induced intramolecular proton transfer within the complex. The T-shaped geometry that possesses C2v symmetry presents a saddle point on the top of the barrier to the in-plane bending of the hydrogen above and below the axis that connects centers of masses of the monomers. The height of this barrier is 7

  10. Design and Organization of the Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT) Trial: a factorial trial evaluating the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from major non-cardiac surgery

    PubMed Central

    2010-01-01

    Background The perioperative period is characterized by an intense inflammatory response. Perioperative inflammation promotes postoperative morbidity and increases mortality. Blunting the inflammatory response to surgical trauma might thus improve perioperative outcomes. We are studying three interventions that potentially modulate perioperative inflammation: corticosteroids, tight glucose control, and light anesthesia. Methods/Design The DeLiT Trial is a factorial randomized single-center trial of dexamethasone vs placebo, intraoperative tight vs. conventional glucose control, and light vs deep anesthesia in patients undergoing major non-cardiac surgery. Anesthetic depth will be estimated with Bispectral Index (BIS) monitoring (Aspect medical, Newton, MA). The primary outcome is a composite of major postoperative morbidity including myocardial infarction, stroke, sepsis, and 30-day mortality. C-reactive protein, a measure of the inflammatory response, will be evaluated as a secondary outcome. One-year all-cause mortality as well as post-operative delirium will be additional secondary outcomes. We will enroll up to 970 patients which will provide 90% power to detect a 40% reduction in the primary outcome, including interim analyses for efficacy and futility at 25%, 50% and 75% enrollment. Discussion The DeLiT trial started in February 2007. We expect to reach our second interim analysis point in 2010. This large randomized controlled trial will provide a reliable assessment of the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from major non-cardiac surgery. The factorial design will enable us to simultaneously study the effects of the three interventions in the same population, both individually and in different combinations. Such a design is an economically efficient way to study the three interventions in one clinical trial vs three. Trial registration This trial is registered at Clinicaltrials

  11. A simple demonstration of zero factorial equals one

    NASA Astrophysics Data System (ADS)

    Mahmood, Munir; Mahmood, Ibtihal

    2016-08-01

    When asked, a number of students answer zero factorial to be zero as a continuation to the answer of one factorial to be one. Any instructor would then seek a justification of zero factorial to be one from computing nCn via the well- known combination formula. This article conveys a simple presentation of zero factorial to be one based on lower and upper bounds of n factorial. We have not seen this explanation covered in any algebra textbook.

  12. Baby factories taint surrogacy in Nigeria.

    PubMed

    Makinde, Olusesan Ayodeji; Makinde, Olufunmbi Olukemi; Olaleye, Olalekan; Brown, Brandon; Odimegwu, Clifford O

    2016-01-01

    The practice of reproductive medicine in Nigeria is facing new challenges with the proliferation of 'baby factories'. Baby factories are buildings, hospitals or orphanages that have been converted into places for young girls and women to give birth to children for sale on the black market, often to infertile couples, or into trafficking rings. This practice illegally provides outcomes (children) similar to surrogacy. While surrogacy has not been well accepted in this environment, the proliferation of baby factories further threatens its acceptance. The involvement of medical and allied health workers in the operation of baby factories raises ethical concerns. The lack of a properly defined legal framework and code of practice for surrogacy makes it difficult to prosecute baby factory owners, especially when they are health workers claiming to be providing services to clients. In this environment, surrogacy and other assisted reproductive techniques urgently require regulation in order to define when ethico-legal lines have been crossed in providing surrogacy or surrogacy-like services. PMID:26602942

  13. Overview of the nearby supernova factory

    SciTech Connect

    Aldering, Greg; Adam, Gilles; Antilogus, Pierre; Astier, Pierre; Bacon, Roland; Bongard, S.; Bonnaud, C.; Copin, Yannick; Hardin, D.; Howell, D. Andy; Lemmonnier, Jean-Pierre; Levy, J.-M.; Loken, S.; Nugent, Peter; Pain, Reynald; Pecontal, Arlette; Pecontal, Emmanuel; Perlmutter, Saul; Quimby, Robert; Schahmaneche, Kyan; Smadja, Gerard; Wood-Vasey, W. Michael

    2002-07-29

    The Nearby Supernova Factory (SNfactory) is an international experiment designed to lay the foundation for the next generation of cosmology experiments (such as CFHTLS, wP, SNAP and LSST) which will measure the expansion history of the Universe using Type Ia supernovae. The SNfactory will discover and obtain frequent lightcurve spectrophotometry covering 3200-10000 {angstrom} for roughly 300 Type Ia supernovae at the low-redshift end of the smooth Hubble flow. The quantity, quality, breadth of galactic environments, and homogeneous nature of the SNfactory dataset will make it the premier source of calibration for the Type Ia supernova width-brightness relation and the intrinsic supernova colors used for K-correction and correction for extinction by host-galaxy dust. This dataset will also allow an extensive investigation of additional parameters which possibly influence the quality of Type Ia supernovae as cosmological probes. The SNfactory search capabilities and follow-up instrumentation include wide-field CCD imagers on two 1.2-m telescopes (via collaboration with the Near Earth Asteroid Tracking team at JPL and the QUEST team at Yale), and a two-channel integral-field-unit optical spectrograph/imager being fabricated for the University of Hawaii 2.2-m telescope. In addition to ground-based follow-up, UV spectra for a subsample of these supernovae will be obtained with HST. The pipeline to obtain, transfer via wireless and standard internet, and automatically process the search images is in operation. Software and hardware development is now underway to enable the execution of follow-up spectroscopy of supernova candidates at the Hawaii 2.2-m telescope via automated remote control of the telescope and the IFU spectrograph/imager.

  14. DKIST enclosure modeling and verification during factory assembly and testing

    NASA Astrophysics Data System (ADS)

    Larrakoetxea, Ibon; McBride, William; Marshall, Heather K.; Murga, Gaizka

    2014-08-01

    The Daniel K. Inouye Solar Telescope (DKIST, formerly the Advanced Technology Solar Telescope, ATST) is unique as, apart from protecting the telescope and its instrumentation from the weather, it holds the entrance aperture stop and is required to position it with millimeter-level accuracy. The compliance of the Enclosure design with the requirements, as of Final Design Review in January 2012, was supported by mathematical models and other analyses which included structural and mechanical analyses (FEA), control models, ventilation analysis (CFD), thermal models, reliability analysis, etc. During the Enclosure Factory Assembly and Testing the compliance with the requirements has been verified using the real hardware and the models created during the design phase have been revisited. The tests performed during shutter mechanism subsystem (crawler test stand) functional and endurance testing (completed summer 2013) and two comprehensive system-level factory acceptance testing campaigns (FAT#1 in December 2013 and FAT#2 in March 2014) included functional and performance tests on all mechanisms, off-normal mode tests, mechanism wobble tests, creation of the Enclosure pointing map, control system tests, and vibration tests. The comparison of the assumptions used during the design phase with the properties measured during the test campaign provides an interesting reference for future projects.

  15. Ergonomic analysis jobs in recovered factories.

    PubMed

    Cuenca, Gabriela; Zotta, Gastón

    2012-01-01

    With the advent of the deep economic crisis in Argentina on 2001, the recovery of companies through to the creation of the Cooperatives Working Self-Management or Factories Recovered by its workers was constituted as one of the ways in which the salaried disobeyed the increasing unemployment. When the companies turn into recovered factories they tend to leave of side practices that have been seen like imposed by the previous organization and not understanding them as a primary condition for the execution of his tasks. Safety and ergonomics are two disciplines that are no longer considered relevant to the daily work. Therefore this investigation aims to revalue, undergo semantic to give back to a place in every organization analyzed. This research developed a self-diagnostic tool for working conditions, and the environment, present in the recovered factories.

  16. The Physics of the B Factories

    NASA Astrophysics Data System (ADS)

    Bevan, A. J.; Golob, B.; Mannel, Th.; Prell, S.; Yabsley, B. D.; Aihara, H.; Anulli, F.; Arnaud, N.; Aushev, T.; Beneke, M.; Beringer, J.; Bianchi, F.; Bigi, I. I.; Bona, M.; Brambilla, N.; Brodzicka, J.; Chang, P.; Charles, M. J.; Cheng, C. H.; Cheng, H.-Y.; Chistov, R.; Colangelo, P.; Coleman, J. P.; Drutskoy, A.; Druzhinin, V. P.; Eidelman, S.; Eigen, G.; Eisner, A. M.; Faccini, R.; Flood, K. T.; Gambino, P.; Gaz, A.; Gradl, W.; Hayashii, H.; Higuchi, T.; Hulsbergen, W. D.; Hurth, T.; Iijima, T.; Itoh, R.; Jackson, P. D.; Kass, R.; Kolomensky, Yu. G.; Kou, E.; Križan, P.; Kronfeld, A.; Kumano, S.; Kwon, Y. J.; Latham, T. E.; Leith, D. W. G. S.; Lüth, V.; Martinez-Vidal, F.; Meadows, B. T.; Mussa, R.; Nakao, M.; Nishida, S.; Ocariz, J.; Olsen, S. L.; Pakhlov, P.; Pakhlova, G.; Palano, A.; Pich, A.; Playfer, S.; Poluektov, A.; Porter, F. C.; Robertson, S. H.; Roney, J. M.; Roodman, A.; Sakai, Y.; Schwanda, C.; Schwartz, A. J.; Seidl, R.; Sekula, S. J.; Steinhauser, M.; Sumisawa, K.; Swanson, E. S.; Tackmann, F.; Trabelsi, K.; Uehara, S.; Uno, S.; van de Water, R.; Vasseur, G.; Verkerke, W.; Waldi, R.; Wang, M. Z.; Wilson, F. F.; Zupan, J.; Zupanc, A.; Adachi, I.; Albert, J.; Banerjee, Sw.; Bellis, M.; Ben-Haim, E.; Biassoni, P.; Cahn, R. N.; Cartaro, C.; Chauveau, J.; Chen, C.; Chiang, C. C.; Cowan, R.; Dalseno, J.; Davier, M.; Davies, C.; Dingfelder, J. C.; Echenard, B.; Epifanov, D.; Fulsom, B. G.; Gabareen, A. M.; Gary, J. W.; Godang, R.; Graham, M. T.; Hafner, A.; Hamilton, B.; Hartmann, T.; Hayasaka, K.; Hearty, C.; Iwasaki, Y.; Khodjamirian, A.; Kusaka, A.; Kuzmin, A.; Lafferty, G. D.; Lazzaro, A.; Li, J.; Lindemann, D.; Long, O.; Lusiani, A.; Marchiori, G.; Martinelli, M.; Miyabayashi, K.; Mizuk, R.; Mohanty, G. B.; Muller, D. R.; Nakazawa, H.; Ongmongkolkul, P.; Pacetti, S.; Palombo, F.; Pedlar, T. K.; Piilonen, L. E.; Pilloni, A.; Poireau, V.; Prothmann, K.; Pulliam, T.; Rama, M.; Ratcliff, B. N.; Roudeau, P.; Schrenk, S.; Schroeder, T.; Schubert, K. R.; Shen, C. P.; Shwartz, B.; Soffer, A.; Solodov, E. P.; Somov, A.; Starič, M.; Stracka, S.; Telnov, A. V.; Todyshev, K. Yu.; Tsuboyama, T.; Uglov, T.; Vinokurova, A.; Walsh, J. J.; Watanabe, Y.; Won, E.; Wormser, G.; Wright, D. H.; Ye, S.; Zhang, C. C.; Abachi, S.; Abashian, A.; Abe, K.; Abe, N.; Abe, R.; Abe, T.; Abrams, G. S.; Adam, I.; Adamczyk, K.; Adametz, A.; Adye, T.; Agarwal, A.; Ahmed, H.; Ahmed, M.; Ahmed, S.; Ahn, B. S.; Ahn, H. S.; Aitchison, I. J. R.; Akai, K.; Akar, S.; Akatsu, M.; Akemoto, M.; Akhmetshin, R.; Akre, R.; Alam, M. S.; Albert, J. N.; Aleksan, R.; Alexander, J. P.; Alimonti, G.; Allen, M. T.; Allison, J.; Allmendinger, T.; Alsmiller, J. R. G.; Altenburg, D.; Alwyn, K. E.; An, Q.; Anderson, J.; Andreassen, R.; Andreotti, D.; Andreotti, M.; Andress, J. C.; Angelini, C.; Anipko, D.; Anjomshoaa, A.; Anthony, P. L.; Antillon, E. A.; Antonioli, E.; Aoki, K.; Arguin, J. F.; Arinstein, K.; Arisaka, K.; Asai, K.; Asai, M.; Asano, Y.; Asgeirsson, D. J.; Asner, D. M.; Aso, T.; Aspinwall, M. L.; Aston, D.; Atmacan, H.; Aubert, B.; Aulchenko, V.; Ayad, R.; Azemoon, T.; Aziz, T.; Azzolini, V.; Azzopardi, D. E.; Baak, M. A.; Back, J. J.; Bagnasco, S.; Bahinipati, S.; Bailey, D. S.; Bailey, S.; Bailly, P.; van Bakel, N.; Bakich, A. M.; Bala, A.; Balagura, V.; Baldini-Ferroli, R.; Ban, Y.; Banas, E.; Band, H. R.; Banerjee, S.; Baracchini, E.; Barate, R.; Barberio, E.; Barbero, M.; Bard, D. J.; Barillari, T.; Barlow, N. R.; Barlow, R. J.; Barrett, M.; Bartel, W.; Bartelt, J.; Bartoldus, R.; Batignani, G.; Battaglia, M.; Bauer, J. M.; Bay, A.; Beaulieu, M.; Bechtle, P.; Beck, T. W.; Becker, J.; Becla, J.; Bedny, I.; Behari, S.; Behera, P. K.; Behn, E.; Behr, L.; Beigbeder, C.; Beiline, D.; Bell, R.; Bellini, F.; Bellodi, G.; Belous, K.; Benayoun, M.; Benelli, G.; Benitez, J. F.; Benkebil, M.; Berger, N.; Bernabeu, J.; Bernard, D.; Bernet, R.; Bernlochner, F. U.; Berryhill, J. W.; Bertsche, K.; Besson, P.; Best, D. S.; Bettarini, S.; Bettoni, D.; Bhardwaj, V.; Bhimji, W.; Bhuyan, B.; Biagini, M. E.; Biasini, M.; van Bibber, K.; Biesiada, J.; Bingham, I.; Bionta, R. M.; Bischofberger, M.; Bitenc, U.; Bizjak, I.; Blanc, F.; Blaylock, G.; Blinov, V. E.; Bloom, E.; Bloom, P. C.; Blount, N. L.; Blouw, J.; Bly, M.; Blyth, S.; Boeheim, C. T.; Bomben, M.; Bondar, A.; Bondioli, M.; Bonneaud, G. R.; Bonvicini, G.; Booke, M.; Booth, J.; Borean, C.; Borgland, A. W.; Borsato, E.; Bosi, F.; Bosisio, L.; Botov, A. A.; Bougher, J.; Bouldin, K.; Bourgeois, P.; Boutigny, D.; Bowerman, D. A.; Boyarski, A. M.; Boyce, R. F.; Boyd, J. T.; Bozek, A.; Bozzi, C.; Bračko, M.; Brandenburg, G.; Brandt, T.; Brau, B.; Brau, J.; Breon, A. B.; Breton, D.; Brew, C.; Briand, H.; Bright-Thomas, P. G.; Brigljević, V.; Britton, D. I.; Brochard, F.; Broomer, B.; Brose, J.; Browder, T. E.; Brown, C. L.; Brown, C. M.; Brown, D. N.; Browne, M.; Bruinsma, M.; Brunet, S.; Bucci, F.; Buchanan, C.; Buchmueller, O. L.; Bünger, C.; Bugg, W.; Bukin, A. D.; Bula, R.; Bulten, H.; Burchat, P. R.; Burgess, W.; Burke, J. P.; Button-Shafer, J.; Buzykaev, A. R.; Buzzo, A.; Cai, Y.; Calabrese, R.; Calcaterra, A.; Calderini, G.; Camanzi, B.; Campagna, E.; Campagnari, C.; Capra, R.; Carassiti, V.; Carpinelli, M.; Carroll, M.; Casarosa, G.; Casey, B. C. K.; Cason, N. M.; Castelli, G.; Cavallo, N.; Cavoto, G.; Cecchi, A.; Cenci, R.; Cerizza, G.; Cervelli, A.; Ceseracciu, A.; Chai, X.; Chaisanguanthum, K. S.; Chang, M. C.; Chang, Y. H.; Chang, Y. W.; Chao, D. S.; Chao, M.; Chao, Y.; Charles, E.; Chavez, C. A.; Cheaib, R.; Chekelian, V.; Chen, A.; Chen, E.; Chen, G. P.; Chen, H. F.; Chen, J.-H.; Chen, J. C.; Chen, K. F.; Chen, P.; Chen, S.; Chen, W. T.; Chen, X.; Chen, X. R.; Chen, Y. Q.; Cheng, B.; Cheon, B. G.; Chevalier, N.; Chia, Y. M.; Chidzik, S.; Chilikin, K.; Chistiakova, M. V.; Cizeron, R.; Cho, I. S.; Cho, K.; Chobanova, V.; Choi, H. H. F.; Choi, K. S.; Choi, S. K.; Choi, Y.; Choi, Y. K.; Christ, S.; Chu, P. H.; Chun, S.; Chuvikov, A.; Cibinetto, G.; Cinabro, D.; Clark, A. R.; Clark, P. J.; Clarke, C. K.; Claus, R.; Claxton, B.; Clifton, Z. C.; Cochran, J.; Cohen-Tanugi, J.; Cohn, H.; Colberg, T.; Cole, S.; Colecchia, F.; Condurache, C.; Contri, R.; Convert, P.; Convery, M. R.; Cooke, P.; Copty, N.; Cormack, C. M.; Dal Corso, F.; Corwin, L. A.; Cossutti, F.; Cote, D.; Cotta Ramusino, A.; Cottingham, W. N.; Couderc, F.; Coupal, D. P.; Covarelli, R.; Cowan, G.; Craddock, W. W.; Crane, G.; Crawley, H. B.; Cremaldi, L.; Crescente, A.; Cristinziani, M.; Crnkovic, J.; Crosetti, G.; Cuhadar-Donszelmann, T.; Cunha, A.; Curry, S.; D'Orazio, A.; Dû, S.; Dahlinger, G.; Dahmes, B.; Dallapiccola, C.; Danielson, N.; Danilov, M.; Das, A.; Dash, M.; Dasu, S.; Datta, M.; Daudo, F.; Dauncey, P. D.; David, P.; Davis, C. L.; Day, C. T.; De Mori, F.; De Domenico, G.; De Groot, N.; De la Vaissière, C.; de la Vaissière, Ch.; de Lesquen, A.; De Nardo, G.; de Sangro, R.; De Silva, A.; DeBarger, S.; Decker, F. J.; del Amo Sanchez, P.; Del Buono, L.; Del Gamba, V.; del Re, D.; Della Ricca, G.; Denig, A. G.; Derkach, D.; Derrington, I. M.; DeStaebler, H.; Destree, J.; Devmal, S.; Dey, B.; Di Girolamo, B.; Marco, E. Di; Dickopp, M.; Dima, M. O.; Dittrich, S.; Dittongo, S.; Dixon, P.; Dneprovsky, L.; Dohou, F.; Doi, Y.; Doležal, Z.; Doll, D. A.; Donald, M.; Dong, L.; Dong, L. Y.; Dorfan, J.; Dorigo, A.; Dorsten, M. P.; Dowd, R.; Dowdell, J.; Drásal, Z.; Dragic, J.; Drummond, B. W.; Dubitzky, R. S.; Dubois-Felsmann, G. P.; Dubrovin, M. S.; Duh, Y. C.; Duh, Y. T.; Dujmic, D.; Dungel, W.; Dunwoodie, W.; Dutta, D.; Dvoretskii, A.; Dyce, N.; Ebert, M.; Eckhart, E. A.; Ecklund, S.; Eckmann, R.; Eckstein, P.; Edgar, C. L.; Edwards, A. J.; Egede, U.; Eichenbaum, A. M.; Elmer, P.; Emery, S.; Enari, Y.; Enomoto, R.; Erdos, E.; Erickson, R.; Ernst, J. A.; Erwin, R. J.; Escalier, M.; Eschenburg, V.; Eschrich, I.; Esen, S.; Esteve, L.; Evangelisti, F.; Everton, C. W.; Eyges, V.; Fabby, C.; Fabozzi, F.; Fahey, S.; Falbo, M.; Fan, S.; Fang, F.; Fanin, C.; Farbin, A.; Farhat, H.; Fast, J. E.; Feindt, M.; Fella, A.; Feltresi, E.; Ferber, T.; Fernholz, R. E.; Ferrag, S.; Ferrarotto, F.; Ferroni, F.; Field, R. C.; Filippi, A.; Finocchiaro, G.; Fioravanti, E.; Firmino da Costa, J.; Fischer, P.-A.; Fisher, A. S.; Fisher, P. H.; Flacco, C. J.; Flack, R. L.; Flaecher, H. U.; Flanagan, J.; Flanigan, J. M.; Ford, K. E.; Ford, W. T.; Forster, I. J.; Forti, A. C.; Forti, F.; Fortin, D.; Foster, B.; Foulkes, S. D.; Fouque, G.; Fox, J.; Franchini, P.; Franco Sevilla, M.; Franek, B.; Frank, E. D.; Fransham, K. B.; Fratina, S.; Fratini, K.; Frey, A.; Frey, R.; Friedl, M.; Fritsch, M.; Fry, J. R.; Fujii, H.; Fujikawa, M.; Fujita, Y.; Fujiyama, Y.; Fukunaga, C.; Fukushima, M.; Fullwood, J.; Funahashi, Y.; Funakoshi, Y.; Furano, F.; Furman, M.; Furukawa, K.; Futterschneider, H.; Gabathuler, E.; Gabriel, T. A.; Gabyshev, N.; Gaede, F.; Gagliardi, N.; Gaidot, A.; Gaillard, J.-M.; Gaillard, J. R.; Galagedera, S.; Galeazzi, F.; Gallo, F.; Gamba, D.; Gamet, R.; Gan, K. K.; Gandini, P.; Ganguly, S.; Ganzhur, S. F.; Gao, Y. Y.; Gaponenko, I.; Garmash, A.; Garra Tico, J.; Garzia, I.; Gaspero, M.; Gastaldi, F.; Gatto, C.; Gaur, V.; Geddes, N. I.; Geld, T. L.; Genat, J.-F.; George, K. A.; George, M.; George, S.; Georgette, Z.; Gershon, T. J.; Gill, M. S.; Gillard, R.; Gilman, J. D.; Giordano, F.; Giorgi, M. A.; Giraud, P.-F.; Gladney, L.; Glanzman, T.; Glattauer, R.; Go, A.; Goetzen, K.; Goh, Y. M.; Gokhroo, G.; Goldenzweig, P.; Golubev, V. B.; Gopal, G. P.; Gordon, A.; Gorišek, A.; Goriletsky, V. I.; Gorodeisky, R.; Gosset, L.; Gotow, K.; Gowdy, S. J.; Graffin, P.; Grancagnolo, S.; Grauges, E.; Graziani, G.; Green, M. G.; Greene, M. G.; Grenier, G. J.; Grenier, P.; Griessinger, K.; Grillo, A. A.; Grinyov, B. V.; Gritsan, A. V.; Grosdidier, G.; Grosse Perdekamp, M.; Grosso, P.; Grothe, M.; Groysman, Y.; Grünberg, O.; Guido, E.; Guler, H.; Gunawardane, N. J. W.; Guo, Q. H.; Guo, R. S.; Guo, Z. J.; Guttman, N.; Ha, H.; Ha, H. C.; Haas, T.; Haba, J.; Hachtel, J.; Hadavand, H. K.; Hadig, T.; Hagner, C.; Haire, M.; Haitani, F.; Haji, T.; Haller, G.; Halyo, V.; Hamano, K.; Hamasaki, H.; Hamel de Monchenault, G.; Hamilton, J.; Hamilton, R.; Hamon, O.; Han, B. Y.; Han, Y. L.; Hanada, H.; Hanagaki, K.; Handa, F.; Hanson, J. E.; Hanushevsky, A.; Hara, K.; Hara, T.; Harada, Y.; Harrison, P. F.; Harrison, T. J.; Harrop, B.; Hart, A. J.; Hart, P. A.; Hartfiel, B. L.; Harton, J. L.; Haruyama, T.; Hasan, A.; Hasegawa, Y.; Hast, C.; Hastings, N. C.; Hasuko, K.; Hauke, A.; Hawkes, C. M.; Hayashi, K.; Hazumi, M.; Hee, C.; Heenan, E. M.; Heffernan, D.; Held, T.; Henderson, R.; Henderson, S. W.; Hertzbach, S. S.; Hervé, S.; Heß, M.; Heusch, C. A.; Hicheur, A.; Higashi, Y.; Higasino, Y.; Higuchi, I.; Hikita, S.; Hill, E. J.; Himel, T.; Hinz, L.; Hirai, T.; Hirano, H.; Hirschauer, J. F.; Hitlin, D. G.; Hitomi, N.; Hodgkinson, M. C.; Höcker, A.; Hoi, C. T.; Hojo, T.; Hokuue, T.; Hollar, J. J.; Hong, T. M.; Honscheid, K.; Hooberman, B.; Hopkins, D. A.; Horii, Y.; Hoshi, Y.; Hoshina, K.; Hou, S.; Hou, W. S.; Hryn'ova, T.; Hsiung, Y. B.; Hsu, C. L.; Hsu, S. C.; Hu, H.; Hu, T.; Huang, H. C.; Huang, T. J.; Huang, Y. C.; Huard, Z.; Huffer, M. E.; Hufnagel, D.; Hung, T.; Hutchcroft, D. E.; Hyun, H. J.; Ichizawa, S.; Igaki, T.; Igarashi, A.; Igarashi, S.; Igarashi, Y.; Igonkina, O.; Ikado, K.; Ikeda, H.; Ikeda, H.; Ikeda, K.; Ilic, J.; Inami, K.; Innes, W. R.; Inoue, Y.; Ishikawa, A.; Ishino, H.; Itagaki, K.; Itami, S.; Itoh, K.; Ivanchenko, V. N.; Iverson, R.; Iwabuchi, M.; Iwai, G.; Iwai, M.; Iwaida, S.; Iwamoto, M.; Iwasaki, H.; Iwasaki, M.; Iwashita, T.; Izen, J. M.; Jackson, D. J.; Jackson, F.; Jackson, G.; Jackson, P. S.; Jacobsen, R. G.; Jacoby, C.; Jaegle, I.; Jain, V.; Jalocha, P.; Jang, H. K.; Jasper, H.; Jawahery, A.; Jayatilleke, S.; Jen, C. M.; Jensen, F.; Jessop, C. P.; Ji, X. B.; John, M. J. J.; Johnson, D. R.; Johnson, J. R.; Jolly, S.; Jones, M.; Joo, K. K.; Joshi, N.; Joshi, N. J.; Judd, D.; Julius, T.; Kadel, R. W.; Kadyk, J. A.; Kagan, H.; Kagan, R.; Kah, D. H.; Kaiser, S.; Kaji, H.; Kajiwara, S.; Kakuno, H.; Kameshima, T.; Kaminski, J.; Kamitani, T.; Kaneko, J.; Kang, J. H.; Kang, J. S.; Kani, T.; Kapusta, P.; Karbach, T. M.; Karolak, M.; Karyotakis, Y.; Kasami, K.; Katano, G.; Kataoka, S. U.; Katayama, N.; Kato, E.; Kato, Y.; Kawai, H.; Kawai, M.; Kawamura, N.; Kawasaki, T.; Kay, J.; Kay, M.; Kelly, M. P.; Kelsey, M. H.; Kent, N.; Kerth, L. T.; Khan, A.; Khan, H. R.; Kharakh, D.; Kibayashi, A.; Kichimi, H.; Kiesling, C.; Kikuchi, M.; Kikutani, E.; Kim, B. H.; Kim, C. H.; Kim, D. W.; Kim, H.; Kim, H. J.; Kim, H. O.; Kim, H. W.; Kim, J. B.; Kim, J. H.; Kim, K. T.; Kim, M. J.; Kim, P.; Kim, S. K.; Kim, S. M.; Kim, T. H.; Kim, Y. I.; Kim, Y. J.; King, G. J.; Kinoshita, K.; Kirk, A.; Kirkby, D.; Kitayama, I.; Klemetti, M.; Klose, V.; Klucar, J.; Knecht, N. S.; Knoepfel, K. J.; Knowles, D. J.; Ko, B. R.; Kobayashi, N.; Kobayashi, S.; Kobayashi, T.; Kobel, M. J.; Koblitz, S.; Koch, H.; Kocian, M. L.; Kodyš, P.; Koeneke, K.; Kofler, R.; Koike, S.; Koishi, S.; Koiso, H.; Kolb, J. A.; Kolya, S. D.; Kondo, Y.; Konishi, H.; Koppenburg, P.; Koptchev, V. B.; Kordich, T. M. B.; Korol, A. A.; Korotushenko, K.; Korpar, S.; Kouzes, R. T.; Kovalskyi, D.; Kowalewski, R.; Kozakai, Y.; Kozanecki, W.; Kral, J. F.; Krasnykh, A.; Krause, R.; Kravchenko, E. A.; Krebs, J.; Kreisel, A.; Kreps, M.; Krishnamurthy, M.; Kroeger, R.; Kroeger, W.; Krokovny, P.; Kronenbitter, B.; Kroseberg, J.; Kubo, T.; Kuhr, T.; Kukartsev, G.; Kulasiri, R.; Kulikov, A.; Kumar, R.; Kumar, S.; Kumita, T.; Kuniya, T.; Kunze, M.; Kuo, C. C.; Kuo, T.-L.; Kurashiro, H.; Kurihara, E.; Kurita, N.; Kuroki, Y.; Kurup, A.; Kutter, P. E.; Kuznetsova, N.; Kvasnička, P.; Kyberd, P.; Kyeong, S. H.; Lacker, H. M.; Lae, C. K.; Lamanna, E.; Lamsa, J.; Lanceri, L.; Landi, L.; Lang, M. I.; Lange, D. J.; Lange, J. S.; Langenegger, U.; Langer, M.; Lankford, A. J.; Lanni, F.; Laplace, S.; Latour, E.; Lau, Y. P.; Lavin, D. R.; Layter, J.; Lebbolo, H.; LeClerc, C.; Leddig, T.; Leder, G.; Le Diberder, F.; Lee, C. L.; Lee, J.; Lee, J. S.; Lee, M. C.; Lee, M. H.; Lee, M. J.; Lee, S.-J.; Lee, S. E.; Lee, S. H.; Lee, Y. J.; Lees, J. P.; Legendre, M.; Leitgab, M.; Leitner, R.; Leonardi, E.; Leonidopoulos, C.; Lepeltier, V.; Leruste, Ph.; Lesiak, T.; Levi, M. E.; Levy, S. L.; Lewandowski, B.; Lewczuk, M. J.; Lewis, P.; Li, H.; Li, H. B.; Li, S.; Li, X.; Li, Y.; Gioi, L. Li; Libby, J.; Lidbury, J.; Lillard, V.; Lim, C. L.; Limosani, A.; Lin, C. S.; Lin, J. Y.; Lin, S. W.; Lin, Y. S.; Lindquist, B.; Lindsay, C.; Lista, L.; Liu, C.; Liu, F.; Liu, H.; Liu, H. M.; Liu, J.; Liu, R.; Liu, T.; Liu, Y.; Liu, Z. Q.; Liventsev, D.; Lo Vetere, M.; Locke, C. B.; Lockman, W. S.; Di Lodovico, F.; Lombardo, V.; London, G. W.; Lopes Pegna, D.; Lopez, L.; Lopez-March, N.; Lory, J.; LoSecco, J. M.; Lou, X. C.; Louvot, R.; Lu, A.; Lu, C.; Lu, M.; Lu, R. S.; Lueck, T.; Luitz, S.; Lukin, P.; Lund, P.; Luppi, E.; Lutz, A. M.; Lutz, O.; Lynch, G.; Lynch, H. L.; Lyon, A. J.; Lyubinsky, V. R.; MacFarlane, D. B.; Mackay, C.; MacNaughton, J.; Macri, M. M.; Madani, S.; Mader, W. F.; Majewski, S. A.; Majumder, G.; Makida, Y.; Malaescu, B.; Malaguti, R.; Malclés, J.; Mallik, U.; Maly, E.; Mamada, H.; Manabe, A.; Mancinelli, G.; Mandelkern, M.; Mandl, F.; Manfredi, P. F.; Mangeol, D. J. J.; Manoni, E.; Mao, Z. P.; Margoni, M.; Marker, C. E.; Markey, G.; Marks, J.; Marlow, D.; Marques, V.; Marsiske, H.; Martellotti, S.; Martin, E. C.; Martin, J. P.; Martin, L.; Martinez, A. J.; Marzolla, M.; Mass, A.; Masuzawa, M.; Mathieu, A.; Matricon, P.; Matsubara, T.; Matsuda, T.; Matsuda, T.; Matsumoto, H.; Matsumoto, S.; Matsumoto, T.; Matsuo, H.; Mattison, T. S.; Matvienko, D.; Matyja, A.; Mayer, B.; Mazur, M. A.; Mazzoni, M. A.; McCulloch, M.; McDonald, J.; McFall, J. D.; McGrath, P.; McKemey, A. K.; McKenna, J. A.; Mclachlin, S. E.; McMahon, S.; McMahon, T. R.; McOnie, S.; Medvedeva, T.; Melen, R.; Mellado, B.; Menges, W.; Menke, S.; Merchant, A. M.; Merkel, J.; Messner, R.; Metcalfe, S.; Metzler, S.; Meyer, N. T.; Meyer, T. I.; Meyer, W. T.; Michael, A. K.; Michelon, G.; Michizono, S.; Micout, P.; Miftakov, V.; Mihalyi, A.; Mikami, Y.; Milanes, D. A.; Milek, M.; Mimashi, T.; Minamora, J. S.; Mindas, C.; Minutoli, S.; Mir, L. M.; Mishra, K.; Mitaroff, W.; Miyake, H.; Miyashita, T. S.; Miyata, H.; Miyazaki, Y.; Moffitt, L. C.; Mohanty, G. B.; Mohapatra, A.; Mohapatra, A. K.; Mohapatra, D.; Moll, A.; Moloney, G. R.; Mols, J. P.; Mommsen, R. K.; Monge, M. R.; Monorchio, D.; Moore, T. B.; Moorhead, G. F.; Mora de Freitas, P.; Morandin, M.; Morgan, N.; Morgan, S. E.; Morganti, M.; Morganti, S.; Mori, S.; Mori, T.; Morii, M.; Morris, J. P.; Morsani, F.; Morton, G. W.; Moss, L. J.; Mouly, J. P.; Mount, R.; Mueller, J.; Müller-Pfefferkorn, R.; Mugge, M.; Muheim, F.; Muir, A.; Mullin, E.; Munerato, M.; Murakami, A.; Murakami, T.; Muramatsu, N.; Musico, P.; Nagai, I.; Nagamine, T.; Nagasaka, Y.; Nagashima, Y.; Nagayama, S.; Nagel, M.; Naisbit, M. T.; Nakadaira, T.; Nakahama, Y.; Nakajima, M.; Nakajima, T.; Nakamura, I.; Nakamura, T.; Nakamura, T. T.; Nakano, E.; Nakayama, H.; Nam, J. W.; Narita, S.; Narsky, I.; Nash, J. A.; Natkaniec, Z.; Nauenberg, U.; Nayak, M.; Neal, H.; Nedelkovska, E.; Negrini, M.; Neichi, K.; Nelson, D.; Nelson, S.; Neri, N.; Nesom, G.; Neubauer, S.; Newman-Coburn, D.; Ng, C.; Nguyen, X.; Nicholson, H.; Niebuhr, C.; Nief, J. Y.; Niiyama, M.; Nikolich, M. B.; Nisar, N. K.; Nishimura, K.; Nishio, Y.; Nitoh, O.; Nogowski, R.; Noguchi, S.; Nomura, T.; Nordby, M.; Nosochkov, Y.; Novokhatski, A.; Nozaki, S.; Nozaki, T.; Nugent, I. M.; O'Grady, C. P.; O'Neale, S. W.; O'Neill, F. G.; Oberhof, B.; Oddone, P. J.; Ofte, I.; Ogawa, A.; Ogawa, K.; Ogawa, S.; Ogawa, Y.; Ohkubo, R.; Ohmi, K.; Ohnishi, Y.; Ohno, F.; Ohshima, T.; Ohshima, Y.; Ohuchi, N.; Oide, K.; Oishi, N.; Okabe, T.; Okazaki, N.; Okazaki, T.; Okuno, S.; Olaiya, E. O.; Olivas, A.; Olley, P.; Olsen, J.; Ono, S.; Onorato, G.; Onuchin, A. P.; Onuki, Y.; Ooba, T.; Orimoto, T. J.; Oshima, T.; Osipenkov, I. L.; Ostrowicz, W.; Oswald, C.; Otto, S.; Oyang, J.; Oyanguren, A.; Ozaki, H.; Ozcan, V. E.; Paar, H. P.; Padoan, C.; Paick, K.; Palka, H.; Pan, B.; Pan, Y.; Panduro Vazquez, W.; Panetta, J.; Panova, A. I.; Panvini, R. S.; Panzenböck, E.; Paoloni, E.; Paolucci, P.; Pappagallo, M.; Paramesvaran, S.; Park, C. S.; Park, C. W.; Park, H.; Park, H. K.; Park, K. S.; Park, W.; Parry, R. J.; Parslow, N.; Passaggio, S.; Pastore, F. C.; Patel, P. M.; Patrignani, C.; Patteri, P.; Pavel, T.; Pavlovich, J.; Payne, D. J.; Peak, L. S.; Peimer, D. R.; Pelizaeus, M.; Pellegrini, R.; Pelliccioni, M.; Peng, C. C.; Peng, J. C.; Peng, K. C.; Peng, T.; Penichot, Y.; Pennazzi, S.; Pennington, M. R.; Penny, R. C.; Penzkofer, A.; Perazzo, A.; Perez, A.; Perl, M.; Pernicka, M.; Perroud, J.-P.; Peruzzi, I. M.; Pestotnik, R.; Peters, K.; Peters, M.; Petersen, B. A.; Petersen, T. C.; Petigura, E.; Petrak, S.; Petrella, A.; Petrič, M.; Petzold, A.; Pia, M. G.; Piatenko, T.; Piccolo, D.; Piccolo, M.; Piemontese, L.; Piemontese, M.; Pierini, M.; Pierson, S.; Pioppi, M.; Piredda, G.; Pivk, M.; Plaszczynski, S.; Polci, F.; Pompili, A.; Poropat, P.; Posocco, M.; Potter, C. T.; Potter, R. J. L.; Prasad, V.; Prebys, E.; Prencipe, E.; Prendki, J.; Prepost, R.; Prest, M.; Prim, M.; Pripstein, M.; Prudent, X.; Pruvot, S.; Puccio, E. M. T.; Purohit, M. V.; Qi, N. D.; Quinn, H.; Raaf, J.; Rabberman, R.; Raffaelli, F.; Ragghianti, G.; Rahatlou, S.; Rahimi, A. M.; Rahmat, R.; Rakitin, A. Y.; Randle-Conde, A.; Rankin, P.; Rashevskaya, I.; Ratkovsky, S.; Raven, G.; Re, V.; Reep, M.; Regensburger, J. J.; Reidy, J.; Reif, R.; Reisert, B.; Renard, C.; Renga, F.; Ricciardi, S.; Richman, J. D.; Ritchie, J. L.; Ritter, M.; Rivetta, C.; Rizzo, G.; Roat, C.; Robbe, P.; Roberts, D. A.; Robertson, A. I.; Robutti, E.; Rodier, S.; Rodriguez, D. M.; Rodriguez, J. L.; Rodriguez, R.; Roe, N. A.; Röhrken, M.; Roethel, W.; Rolquin, J.; Romanov, L.; Romosan, A.; Ronan, M. T.; Rong, G.; Ronga, F. J.; Roos, L.; Root, N.; Rosen, M.; Rosenberg, E. I.; Rossi, A.; Rostomyan, A.; Rotondo, M.; Roussot, E.; Roy, J.; Rozanska, M.; Rozen, Y.; Rozen, Y.; Rubin, A. E.; Ruddick, W. O.; Ruland, A. M.; Rybicki, K.; Ryd, A.; Ryu, S.; Ryuko, J.; Sabik, S.; Sacco, R.; Saeed, M. A.; Safai Tehrani, F.; Sagawa, H.; Sahoo, H.; Sahu, S.; Saigo, M.; Saito, T.; Saitoh, S.; Sakai, K.; Sakamoto, H.; Sakaue, H.; Saleem, M.; Salnikov, A. A.; Salvati, E.; Salvatore, F.; Samuel, A.; Sanders, D. A.; Sanders, P.; Sandilya, S.; Sandrelli, F.; Sands, W.; Sands, W. R.; Sanpei, M.; Santel, D.; Santelj, L.; Santoro, V.; Santroni, A.; Sanuki, T.; Sarangi, T. R.; Saremi, S.; Sarti, A.; Sasaki, T.; Sasao, N.; Satapathy, M.; Sato, Nobuhiko; Sato, Noriaki; Sato, Y.; Satoyama, N.; Satpathy, A.; Savinov, V.; Savvas, N.; Saxton, O. H.; Sayeed, K.; Schaffner, S. F.; Schalk, T.; Schenk, S.; Schieck, J. R.; Schietinger, T.; Schilling, C. J.; Schindler, R. H.; Schmid, S.; Schmitz, R. E.; Schmuecker, H.; Schneider, O.; Schnell, G.; Schönmeier, P.; Schofield, K. C.; Schott, G.; Schröder, H.; Schram, M.; Schubert, J.; Schümann, J.; Schultz, J.; Schumm, B. A.; Schune, M. H.; Schwanke, U.; Schwarz, H.; Schwiening, J.; Schwierz, R.; Schwitters, R. F.; Sciacca, C.; Sciolla, G.; Scott, I. J.; Seeman, J.; Seiden, A.; Seitz, R.; Seki, T.; Sekiya, A. I.; Semenov, S.; Semmler, D.; Sen, S.; Senyo, K.; Seon, O.; Serbo, V. V.; Serednyakov, S. I.; Serfass, B.; Serra, M.; Serrano, J.; Settai, Y.; Seuster, R.; Sevior, M. E.; Shakhova, K. V.; Shang, L.; Shapkin, M.; Sharma, V.; Shebalin, V.; Shelkov, V. G.; Shen, B. C.; Shen, D. Z.; Shen, Y. T.; Sherwood, D. J.; Shibata, T.; Shibata, T. A.; Shibuya, H.; Shidara, T.; Shimada, K.; Shimoyama, M.; Shinomiya, S.; Shiu, J. G.; Shorthouse, H. W.; Shpilinskaya, L. I.; Sibidanov, A.; Sicard, E.; Sidorov, A.; Sidorov, V.; Siegle, V.; Sigamani, M.; Simani, M. C.; Simard, M.; Simi, G.; Simon, F.; Simonetto, F.; Sinev, N. B.; Singh, H.; Singh, J. B.; Sinha, R.; Sitt, S.; Skovpen, Yu. I.; Sloane, R. J.; Smerkol, P.; Smith, A. J. S.; Smith, D.; Smith, D. S.; Smith, J. G.; Smol, A.; Snoek, H. L.; Snyder, A.; So, R. Y.; Sobie, R. J.; Soderstrom, E.; Soha, A.; Sohn, Y. S.; Sokoloff, M. D.; Sokolov, A.; Solagna, P.; Solovieva, E.; Soni, N.; Sonnek, P.; Sordini, V.; Spaan, B.; Spanier, S. M.; Spencer, E.; Speziali, V.; Spitznagel, M.; Spradlin, P.; Staengle, H.; Stamen, R.; Stanek, M.; Stanič, S.; Stark, J.; Steder, M.; Steininger, H.; Steinke, M.; Stelzer, J.; Stevanato, E.; Stocchi, A.; Stock, R.; Stoeck, H.; Stoker, D. P.; Stroili, R.; Strom, D.; Strother, P.; Strube, J.; Stugu, B.; Stypula, J.; Su, D.; Suda, R.; Sugahara, R.; Sugi, A.; Sugimura, T.; Sugiyama, A.; Suitoh, S.; Sullivan, M. K.; Sumihama, M.; Sumiyoshi, T.; Summers, D. J.; Sun, L.; Sun, S.; Sundermann, J. E.; Sung, H. F.; Susaki, Y.; Sutcliffe, P.; Suzuki, A.; Suzuki, J.; Suzuki, J. I.; Suzuki, K.; Suzuki, S.; Suzuki, S. Y.; Swain, J. E.; Swain, S. K.; T'Jampens, S.; Tabata, M.; Tackmann, K.; Tajima, H.; Tajima, O.; Takahashi, K.; Takahashi, S.; Takahashi, T.; Takasaki, F.; Takayama, T.; Takita, M.; Tamai, K.; Tamponi, U.; Tamura, N.; Tan, N.; Tan, P.; Tanabe, K.; Tanabe, T.; Tanaka, H. A.; Tanaka, J.; Tanaka, M.; Tanaka, S.; Tanaka, Y.; Tanida, K.; Taniguchi, N.; Taras, P.; Tasneem, N.; Tatishvili, G.; Tatomi, T.; Tawada, M.; Taylor, F.; Taylor, G. N.; Taylor, G. P.; Telnov, V. I.; Teodorescu, L.; Ter-Antonyan, R.; Teramoto, Y.; Teytelman, D.; Thérin, G.; Thiebaux, Ch.; Thiessen, D.; Thomas, E. W.; Thompson, J. M.; Thorne, F.; Tian, X. C.; Tibbetts, M.; Tikhomirov, I.; Tinslay, J. S.; Tiozzo, G.; Tisserand, V.; Tocut, V.; Toki, W. H.; Tomassini, E. W.; Tomoto, M.; Tomura, T.; Torassa, E.; Torrence, E.; Tosi, S.; Touramanis, C.; Toussaint, J. C.; Tovey, S. N.; Trapani, P. P.; Treadwell, E.; Triggiani, G.; Trincaz-Duvoid, S.; Trischuk, W.; Troost, D.; Trunov, A.; Tsai, K. L.; Tsai, Y. T.; Tsujita, Y.; Tsukada, K.; Tsukamoto, T.; Tuggle, J. M.; Tumanov, A.; Tung, Y. W.; Turnbull, L.; Turner, J.; Turri, M.; Uchida, K.; Uchida, M.; Uchida, Y.; Ueki, M.; Ueno, K.; Ujiie, N.; Ulmer, K. A.; Unno, Y.; Urquijo, P.; Ushiroda, Y.; Usov, Y.; Usseglio, M.; Usuki, Y.; Uwer, U.; Va'vra, J.; Vahsen, S. E.; Vaitsas, G.; Valassi, A.; Vallazza, E.; Vallereau, A.; Vanhoefer, P.; van Hoek, W. C.; Van Hulse, C.; van Winkle, D.; Varner, G.; Varnes, E. W.; Varvell, K. E.; Vasileiadis, G.; Velikzhanin, Y. S.; Verderi, M.; Versillé, S.; Vervink, K.; Viaud, B.; Vidal, P. B.; Villa, S.; Villanueva-Perez, P.; Vinograd, E. L.; Vitale, L.; Vitug, G. M.; Voß, C.; Voci, C.; Voena, C.; Volk, A.; von Wimmersperg-Toeller, J. H.; Vorobyev, V.; Vossen, A.; Vuagnin, G.; Vuosalo, C. O.; Wacker, K.; Wagner, A. P.; Wagner, D. L.; Wagner, G.; Wagner, M. N.; Wagner, S. R.; Wagoner, D. E.; Walker, D.; Walkowiak, W.; Wallom, D.; Wang, C. C.; Wang, C. H.; Wang, J.; Wang, J. G.; Wang, K.; Wang, L.; Wang, L. L.; Wang, P.; Wang, T. J.; Wang, W. F.; Wang, X. L.; Wang, Y. F.; Wappler, F. R.; Watanabe, M.; Watson, A. T.; Watson, J. E.; Watson, N. K.; Watt, M.; Weatherall, J. H.; Weaver, M.; Weber, T.; Wedd, R.; Wei, J. T.; Weidemann, A. W.; Weinstein, A. J. R.; Wenzel, W. A.; West, C. A.; West, C. G.; West, T. J.; White, E.; White, R. M.; Wicht, J.; Widhalm, L.; Wiechczynski, J.; Wienands, U.; Wilden, L.; Wilder, M.; Williams, D. C.; Williams, G.; Williams, J. C.; Williams, K. M.; Williams, M. I.; Willocq, S. Y.; Wilson, J. R.; Wilson, M. G.; Wilson, R. J.; Winklmeier, F.; Winstrom, L. O.; Winter, M. A.; Wisniewski, W. J.; Wittgen, M.; Wittlin, J.; Wittmer, W.; Wixted, R.; Woch, A.; Wogsland, B. J.; Won, E.; Wong, Q. K.; Wray, B. C.; Wren, A. C.; Wright, D. M.; Wu, C. H.; Wu, J.; Wu, S. L.; Wulsin, H. W.; Xella, S. M.; Xie, Q. L.; Xie, Y.; Xu, Z. Z.; Yéche, Ch.; Yamada, Y.; Yamaga, M.; Yamaguchi, A.; Yamaguchi, H.; Yamaki, T.; Yamamoto, H.; Yamamoto, N.; Yamamoto, R. K.; Yamamoto, S.; Yamanaka, T.; Yamaoka, H.; Yamaoka, J.; Yamaoka, Y.; Yamashita, Y.; Yamauchi, M.; Yan, D. S.; Yan, Y.; Yanai, H.; Yanaka, S.; Yang, H.; Yang, R.; Yang, S.; Yarritu, A. K.; Yashchenko, S.; Yashima, J.; Yasin, Z.; Yasu, Y.; Ye, S. W.; Yeh, P.; Yi, J. I.; Yi, K.; Yi, M.; Yin, Z. W.; Ying, J.; Yocky, G.; Yokoyama, K.; Yokoyama, M.; Yokoyama, T.; Yoshida, K.; Yoshida, M.; Yoshimura, Y.; Young, C. C.; Yu, C. X.; Yu, Z.; Yuan, C. Z.; Yuan, Y.; Yumiceva, F. X.; Yusa, Y.; Yushkov, A. N.; Yuta, H.; Zacek, V.; Zain, S. B.; Zallo, A.; Zambito, S.; Zander, D.; Zang, S. L.; Zanin, D.; Zaslavsky, B. G.; Zeng, Q. L.; Zghiche, A.; Zhang, B.; Zhang, J.; Zhang, J.; Zhang, L.; Zhang, L. M.; Zhang, S. Q.; Zhang, Z. P.; Zhao, H. W.; Zhao, M.; Zhao, Z. G.; Zheng, Y.; Zheng, Y. H.; Zheng, Z. P.; Zhilich, V.; Zhou, P.; Zhu, R. Y.; Zhu, Y. S.; Zhu, Z. M.; Zhulanov, V.; Ziegler, T.; Ziegler, V.; Zioulas, G.; Zisman, M.; Zito, M.; Zürcher, D.; Zwahlen, N.; Zyukova, O.; Živko, T.; Žontar, D.

    2014-11-01

    This work is on the Physics of the B Factories. Part A of this book contains a brief description of the SLAC and KEK B Factories as well as their detectors, BaBar and Belle, and data taking related issues. Part B discusses tools and methods used by the experiments in order to obtain results. The results themselves can be found in Part C. Please note that version 3 on the archive is the auxiliary version of the Physics of the B Factories book. This uses the notation alpha, beta, gamma for the angles of the Unitarity Triangle. The nominal version uses the notation phi_1, phi_2 and phi_3. Please cite this work as Eur. Phys. J. C74 (2014) 3026.

  17. "Fab 13": The Learning Factory.

    ERIC Educational Resources Information Center

    Crooks, Steven M.; Eucker, Tom R.

    2001-01-01

    Describes how situated learning theory was employed in the design of Fab 13, a four-day simulation-based learning experience for manufacturing professionals at Intel Corporation. Presents a conceptual framework for understanding situated learning and discusses context, content, anchored instruction, facilitation, scaffolding, collaborating,…

  18. Structural analysis of polymer thin films using GISAXS in the tender X-ray region: Concept and design of GISAXS experiments using the tender X-ray energy at BL-15A2 at the Photon Factory

    NASA Astrophysics Data System (ADS)

    Takagi, H.; Igarashi, N.; Mori, T.; Saijo, S.; Nagatani, Y.; Ohta, H.; Yamamoto, K.; Shimizu, N.

    2016-10-01

    If small angle X-ray scattering (SAXS) utilizing the soft X-ray region is available, advanced and unique experiments, which differ from traditional SAXS methods, can be realized. For example, grazing-incidence small angle X-ray scattering (GISAXS) using hard X-ray is a powerful tool for understanding the nanostructure in both vertical and lateral directions of thin films, while GISAXS utilizing the tender X-ray region (SX-GISAXS) enables depth-resolved analysis as well as a standard GISAXS analysis in thin films. Thus, at BL-15A2 at the Photon Factory, a dedicated diffractometer for SX-GISAXS (above 2.1 keV) was constructed. This diffractometer is composed of four vacuum chambers and can be converted into the vacuum state from the sample chamber in front of the detector surface. Diffractions are clearly observed until 12th peak when measuring collagen by SAXS with an X-ray energy of 2.40 keV and a camera length of 825 mm. Additionally, we conducted the model experiment using SX-GISAXS with an X-ray energy of 2.40 keV to confirm that a poly(methyl methacrylate)-poly(n-butyl acrylate) block copolymer thin film has a microphase-separated structure in the thin film, which is composed of lamellae aligned both parallel and perpendicular to the substrate surface. Similarly, in a polystyrene-poly(methyl methacrylate) block copolymer thin film, SX-GISAXS with 3.60 keV and 5.73 keV revealed that hexagonally packed cylinders are aligned parallel to the substrate surface. The incident angle dependence of the first order peak position of the qz direction obtained from experiments at various incident X-ray energies agrees very well with the theoretical one calculated from the distorted wave Born approximation.

  19. Radiative Penguin Decays at the B Factories

    SciTech Connect

    Koneke, Karsten; /MIT, LNS

    2007-11-16

    In this article, I review the most recent results in radiative penguin decays from the B factories Belle and BABAR. Most notably, I will talk about the recent new observations in the decays B {yields} ({rho}/{omega}) {gamma}, a new analysis technique in b {yields} s{gamma}, and first measurements of radiative penguin decays in the B{sup 0}{sub s} meson system. Finally, I will summarize the current status and future prospects of radiative penguin B physics at the B factories.

  20. From super beams to neutrino factories

    SciTech Connect

    Bross, Alan; /Fermilab

    2009-11-01

    The Neutrino Factory, which produces an extremely intense source of flavor-tagged neutrinos from muon decays in a storage ring, arguably gives the best physics reach for CP violation, as well as virtually all parameters in the neutrino oscillation parameter space. I will briefly describe the physics capabilities of the baseline Neutrino Factory as compared to other possible future facilities ({beta}-beam and super-beam facilities), give an overview of the accelerator complex and describe in detail the current international R&D program.

  1. Multilevel Factorial Experiments for Developing Behavioral Interventions: Power, Sample Size, and Resource Considerations

    ERIC Educational Resources Information Center

    Dziak, John J.; Nahum-Shani, Inbal; Collins, Linda M.

    2012-01-01

    Factorial experimental designs have many potential advantages for behavioral scientists. For example, such designs may be useful in building more potent interventions by helping investigators to screen several candidate intervention components simultaneously and to decide which are likely to offer greater benefit before evaluating the intervention…

  2. A Methodology for the Assessment of Experiential Learning Lean: The Lean Experience Factory Study

    ERIC Educational Resources Information Center

    De Zan, Giovanni; De Toni, Alberto Felice; Fornasier, Andrea; Battistella, Cinzia

    2015-01-01

    Purpose: The purpose of this paper is to present a methodology to assess the experiential learning processes of learning lean in an innovative learning environment: the lean model factories. Design/methodology/approach: A literature review on learning and lean management literatures was carried out to design the methodology. Then, a case study…

  3. Interaction Region Upgrades of e+ e- B-Factories

    SciTech Connect

    Sullivan, M.; /SLAC

    2008-02-22

    Both the PEP-II and KEKB B-Factories have plans to upgrade their Interaction Regions (IRs) in order to improve luminosity performance. Last summer PEP-II added cooling to the IR beam pipe in order to increase beam currents thereby raising the luminosity. In addition, PEP-II is working on a design that modifies the permanent magnets near the Interaction Point (IP) for an even higher luminosity increase. KEKB is also planning an improvement to their IR that will decrease the detector beam pipe radius. In addition, KEK has a design to increase the luminosity of KEKB to 1 x 10{sup 35} cm{sup -2} sec{sup -1} which includes changes to the IR. PEP-II is also investigating the feasibility of a 1 x 10{sup 36} cm{sup -2} sec{sup -1} luminosity design. I summarize these various upgrades and concentrate on issues common to the different designs.

  4. MUON EDM EXPERIMENT USING STAGE II OF THE NEUTRINO FACTORY.

    SciTech Connect

    FERNOW,R.C.; GALLARDO,J.C.; MORSE,W.M.; SEMERTZIDIS,Y.K.

    2002-07-01

    During the second stage of a future neutrino factory unprecedented numbers of bunched muons will become available. The cooled medium-energy muon beam could be used for a high sensitivity search for an electric dipole moment (EDM) of the muon with a sensitivity better than 10{sup -24}e {center_dot} cm. This will make the sensitivity of the EDM experiment to non-standard physics competitive and in many models more sensitive than the present limits on edms of the electron and nucleons. The experimental design exploits the strong motional electric field sensed by relativistic particles in a magnetic storage ring.

  5. The International Muon Ionization Cooling Experiment: MICE and Neutrino Factories

    NASA Astrophysics Data System (ADS)

    Freemire, Ben

    2010-03-01

    The Muon Ionization Cooling Experiment (MICE) is an accelerator and particle physics experiment aimed at demonstrating the technique of ionization cooling on a beam of muons. Ionization cooling is the process by which muons are sent through an absorbing material, thereby losing energy and decreasing their normalized emittance. The muons are then reaccelerated in the appropriate direction with radio frequency (RF) cavities. This produces an overall reduction in transverse emittance of the muon beam. Ionization cooling could be a key technique in the design of a high intensity Neutrino Factory.

  6. A database for operation logging of the KEK photon factory

    NASA Astrophysics Data System (ADS)

    Pak, Cheol On

    1990-08-01

    A prototype database for operation logging of the KEK Photon Factory storage ring has been constructed and tested. This paper describes the basic design of the operation logging system and its performance. Front-end control computers gather various data concerning the operation of the storage ring, and transfer them to a large general-purpose computer through a token-ring network. We have adopted a relational database system so as to save large amounts of data under daily operation. An interactive software tool was developed to retrieve data and to make graphic representations easily.

  7. Distributed Sensing and Control Architecture for Automotive Factory Automation

    NASA Astrophysics Data System (ADS)

    Cai, Ningxu; Brennan, Robert W.

    In this paper we propose an architecture for distributed intelligent sensing and control (DISC) for automotive factory automation. The architecture is based on a platform-based design approach that breaks the sensing and control problem into increasingly higher levels of abstraction from physical hardware to intelligent sensing and control. The focus of this paper is on the middleware layer that serves as an interface between an upper, agent-based control level and the wireless sensor network. This layer takes advantage the IEC 61499 model for distributed process measurement and control, and in particular, exploits its distributed, modular structure and its close match to wireless sensor systems.

  8. THE ROLE OF QUANTUM MECHANICS IN NEUTRINO FACTORIES.

    SciTech Connect

    GALLARDO,J.C.; SESSLER,A.M.; WURTELE,J.

    2000-12-06

    A compilation is made of the various ways in which quantum phenomena enter into the design and operation of a neutrino factory. They include production of pions, decay of pions into muons, ionization energy loss of muons in material, scattering and energy straggling of muons in material, polarization of muons, and the decay of muons into neutrinos, and the radiation effect of neutrinos. For each process formulas are presented which cover the basic mechanism. A discussion is presented of the areas of uncertainty and of the experiments, underway and proposed, which will reduce the uncertainty to an acceptable level.

  9. Neutrino factory and muon collider collaboration R and D activities

    SciTech Connect

    Zisman, Michael S.; Neutrino Factory and Muon Collider Collaborat

    2001-03-22

    The Neutrino Factory and Muon Collider Collaboration (MC) comprises about 140 U.S. and non-U.S. accelerator and particle physicists. The MC is carrying out an R and D program aimed at validating the critical design concepts required for the construction of such machines. We are committed to encouraging international cooperation and coordination of the R and D effort. Main activities of the MC include a Targetry program, a MUCOOL program, a component development program, and a theory and simulation effort. Moreover, the MC has participated in several feasibility studies for a complete Neutrino Factory facility, with the aim of identifying any additional R and D activities needed to prepare a Zeroth-order Design Report (ZDR) in about two years and a Conceptual Design report (CDR) about two years thereafter. In this paper, the R and D goals in each area will be indicated, and the present status and future plans of the R and D program will be described.

  10. The Factory of the Future

    NASA Technical Reports Server (NTRS)

    Byman, J. E.

    1985-01-01

    A brief history of aircraft production techniques is given. A flexible machining cell is then described. It is a computer controlled system capable of performing 4-axis machining part cleaning, dimensional inspection and materials handling functions in an unmanned environment. The cell was designed to: allow processing of similar and dissimilar parts in random order without disrupting production; allow serial (one-shipset-at-a-time) manufacturing; reduce work-in-process inventory; maximize machine utilization through remote set-up; maximize throughput and minimize labor.

  11. Making Connections: After the Factories Revisited.

    ERIC Educational Resources Information Center

    Rosenfeld, Stuart A.; Bergman, Edward M.

    This analysis of employment patterns in the American South extends a 1985 report, "After the Factories: Changing Employment Patterns in the Rural South," which was based on the years between 1977-1982. The 1985 report included Texas, but this analysis includes only the 12 Southern Growth Policies Board (SGPB) member states. This new analysis…

  12. Speech Differences of Factory Worker Age Groups.

    ERIC Educational Resources Information Center

    Tway, Patricia

    1975-01-01

    This article, which focuses on speech differences of age groups, is part of a larger study of occupational jargon, its characteristics and underlying features and the part it plays in reflecting the workers' knowledge of their jobs and their attitudes toward jobs in general. The project incorporated a case method of research in a china factory.…

  13. An Epiphany in a Toilet Factory

    ERIC Educational Resources Information Center

    Cobb, Catlin

    2009-01-01

    In this article, the author shares her experiences of the universality of art making and artistic experience of being a dancer and teaching artist. She describes her performance at Kohler, a worldwide leader in plumbing products in Spartanburg, South Carolina, where she had an epiphany dancing in a toilet factory--a sudden, intuitive moment of…

  14. Investigation of Beam Loading Effects for the Neutrino Factory Muon Accelerator

    SciTech Connect

    J. Pozimski,M. Aslaninejad,C. Bontoiu,S. Berg,Alex Bogacz

    2010-05-01

    The International design study (IDS) study showed that a Neutrino Factory [1] seems to be the most promising candidate for the next phase of high precision neutrino oscillation experiments. One part of the increased precision is due to the fact that in a Neutrino Factory the decay of muons produces a neutrino beam with narrow energy distribution and divergence. The effect of beam loading on the energy distribution of the muon beam in the Neutrino Factory decay rings has been investigated numerically. The simulations have been performed using the baseline accelerator design including cavities for different number of bunch trains and bunch train timing. A detailed analysis of the beam energy distribution expected is given together with a discussion of the energy spread produced by the gutter acceleration in the FFAG and the implications for the neutrino oscillation experiments will be presented.

  15. Muon Bunching and Phase-Energy Rotation for a Neutrino Factory and Muon Collider

    NASA Astrophysics Data System (ADS)

    Neuffer, David; Yoshikawa, Cary

    2008-04-01

    We have developed scenarios for capture, bunching and phase-energy rotation of muons from a proton source, using high-frequency rf systems. The method captures a maximal number of muons into a string of rf bunches with initial application in the neutrino factory design studies. For a muon collider, these bunches must be recombined for maximal luminosity, and our initial design produced a relatively long bunch train. In this paper we present more compact scenarios that obtain a smaller number of bunches, and, after some optimization, obtain cases that are better for both neutrino-factory and collider scenarios. We also consider further modification by incorporating hydrogen gas-filled rf cavities for bunching and cooling. We describe these examples and consider variations toward an optimal factory + collider scenario.

  16. 4. OVERALL VIEW OF FACTORY COMPLEX, WITH DIGESTER HOUSE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. OVERALL VIEW OF FACTORY COMPLEX, WITH DIGESTER HOUSE IN LEFT FOREGROUND. VIEW TO NORTHWEST. - Commercial & Industrial Buildings, Maizewood Insulation Company Factory, 275 Salina Street, Dubuque, Dubuque County, IA

  17. 2. OVERALL VIEW OF FACTORY COMPLEX, WITH BOILER HOUSE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. OVERALL VIEW OF FACTORY COMPLEX, WITH BOILER HOUSE IN CENTER GROUND. VIEW TO NORTH. - Commercial & Industrial Buildings, Maizewood Insulation Company Factory, 275 Salina Street, Dubuque, Dubuque County, IA

  18. 5. OVERALL VIEW OF FACTORY COMPLEX, WITH DIGESTER HOUSE IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. OVERALL VIEW OF FACTORY COMPLEX, WITH DIGESTER HOUSE IN LEFT FOREGROUND. VIEW TO NORTHWEST. - Commercial & Industrial Buildings, Maizewood Insulation Company Factory, 275 Salina Street, Dubuque, Dubuque County, IA

  19. 1. EAST AND NORTH FACADES OF NABISCO CARTON FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. EAST AND NORTH FACADES OF NABISCO CARTON FACTORY, LOOKING SOUTHWEST ALONG MARSEILLES POWER CANAL - National Biscuit Company, Marseilles Factory, Off Main Street on Marseilles Power Canal, Marseilles, La Salle County, IL

  20. Production of Tetraquark State Tcc at B-Factories

    NASA Astrophysics Data System (ADS)

    Reyima, Rashidin

    2013-12-01

    We study production of the tetraquark state Tcc via virtual photon at the B-factories in the QCD factorization framework. We predict the cross section of tetraquark state production in the leading order at the B-factories.

  1. The Virtual Factory Teaching System (VFTS): Project Review and Results.

    ERIC Educational Resources Information Center

    Kazlauskas, E. J.; Boyd, E. F., III; Dessouky, M. M.

    This paper presents a review of the Virtual Factory Teaching (VFTS) project, a Web-based, multimedia collaborative learning network. The system allows students, working alone or in teams, to build factories, forecast demand for products, plan production, establish release rules for new work into the factory, and set scheduling rules for…

  2. 3. SOUTH AND WEST ELEVATION OF IPA FACTORY; TWOSTORY SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. SOUTH AND WEST ELEVATION OF IPA FACTORY; TWO-STORY SECTION WITH BRICK PARAPET BUILT WITH FACTORY EXPANSION CA. 1948. GABLE ROOF SECTION IS PART OF ORIGINAL 1892 FACTORY. TO THE RIGHT IS AN ABANDONED (COMMONWEALTH EDISON) ELECTRICAL SUBSTATION. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  3. 2. LOOKING NORTH ON COMMERCE ST. SHOWING HARMON MATTRESS FACTORY. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. LOOKING NORTH ON COMMERCE ST. SHOWING HARMON MATTRESS FACTORY. BRIDGE CONNECTS HARMON MATTRESS FACTORY WITH HARMON WAREHOUSE (SEE PHOTO HABS WA-165-15). BUILDING IN LEFT FOREGROUND IS LINDSTROM-BERG CABINET FACTORY (SEE PHOTO HABS WA-165-36). - Union Depot Area Study, F. S. Harmon Mattress Company, 1953 South C Street, Tacoma, Pierce County, WA

  4. Testing Factorial Invariance in Multilevel Data: A Monte Carlo Study

    ERIC Educational Resources Information Center

    Kim, Eun Sook; Kwok, Oi-man; Yoon, Myeongsun

    2012-01-01

    Testing factorial invariance has recently gained more attention in different social science disciplines. Nevertheless, when examining factorial invariance, it is generally assumed that the observations are independent of each other, which might not be always true. In this study, we examined the impact of testing factorial invariance in multilevel…

  5. Nanotechnology, bionanotechnology and microbial cell factories

    PubMed Central

    2010-01-01

    Nanotechnology is increasingly using both materials and nano-objects synthesized by living beings, most of them produced by microbial cells. Emerging technologies and highly integrative approaches (such as 'omics and systems biology), that have been largely proven successful for the production of proteins and secondary metabolites are now expected to become fully adapted for the improved biological production of nanostructured materials with tailored properties. The so far underestimated potential of microbial cell factories in nanotechnology and nanomedicine is expected to emerge, in the next years, in the context of novel needs envisaged in the nanoscience universe. This should prompt a careful revisiting of the microbial cell factories as the most versatile biological platforms to supply functional materials for nanotechnological applications. PMID:20602780

  6. China's factory floors: an industrial hygienist's view.

    PubMed

    Brown, Garrett D

    2003-01-01

    Determinants of workplace health and safety in China, including work organization, composition of the workforce, production regimens, lack of independent worker representation, and the status of government regulatory enforcement, are described and analyzed. The findings of reports of nongovernmental organizations and media articles are summarized. Key markers of working conditions in export-sector factories, i.e., accident and safety program compliance rates, chemical and noise exposures, and machine guarding issues, are analyzed. Four factors for improving workplace health and safety are proposed: 1) employer commitment and implementation of effective health and safety programs on a plant level; 2) Chinese government enforcement of regulations; 3) meaningful involvement of workers in plant health and safety programs; and 4) continued involvement of international professionals and "civil society" both to pressure multinational corporations and the Chinese government and to provide technical assistance and resources for building the capacity of employers, workers, and government agencies to improve factory working conditions in the world's fastest growing economy.

  7. Reactions of the bis(dialkylphosphino)methane complexes Pd2X2(μ-R2PCH2PR2)2 (X = halogen, R = Me or Et) with H2S, S8, COS, and CS2; detection of reaction intermediates.

    PubMed

    Pamplin, Craig B; Rettig, Steven J; Patrick, Brian O; James, Brian R

    2011-09-01

    The Pd(2)X(2)(dmpm)(2) complexes [X = Cl (1a), Br (1b), I (1c); dmpm = bis(dimethylphosphino)methane. In all the dipalladium complexes mentioned in this paper, the dmpm, depm, and dppm ligands (unless stated otherwise) are bridging, but for convenience the μ-symbol is omitted.] react with H(2)S to yield H(2) and the bridged-sulfido complexes Pd(2)X(2)(μ-S)(dmpm)(2) (2a-c), of which 2a and 2b are structurally characterized. With 1a, two rapid reversible equilibria are observed by NMR spectroscopy below -30 °C, and two reaction intermediates are detected; both are likely hydrido(mercapto) species. Reaction of 1a with 1 equiv of elemental sulfur also yields 2a. The reaction of 1a with COS results in the initial formation of Pd(2)Cl(2)(μ-COS)(dmpm)(2) (3) that undergoes decarbonylation to yield 2a and Pd(2)Cl(2)(μ-CO)(dmpm)(2) (4), which is also formed via reversible insertion of the CO into the Pd-Pd bond of 1a. The solid-state molecular structure of the previously reported complex Pd(2)Cl(2)(μ-CS(2))(dmpm)(2) (5), together with solution NMR data for 3 and 5, reveal that the bridging heterocumulene ligands coordinate in an η(2)-C,S fashion. Analogous findings were made for the corresponding Pd(2)X(2)(depm)(2) complexes [X = Cl (1a'), Br (1b'), I (1c'); depm = bis(diethylphosphino)methane], although no μ-COS species was detected. The Pd(2)X(2)(μ-S)(depm)(2) complex was structurally characterized. Differences in the chemistry of the previously studied, corresponding dppm systems (dppm = bis(diphenylphosphino)methane) are discussed.

  8. On near detectors at a neutrino factory

    SciTech Connect

    Tang Jian; Winter, Walter

    2010-03-30

    The geometric effects of the beam in near detectors at a neutrino factory are discussed. The refined systematics treatment, including cross section errors, flux errors and background uncertainties, is compared with the IDS-NF one. Different near detector setups are included. We also probe their effects both at the measurements of standard neutrino oscillation parameters and constraints of the non-standard neutrino interaction.

  9. Anaerobic digestion of cassava starch factory effluent.

    PubMed

    Manilal, V B; Narayanan, C S; Balagopalan, C

    1990-06-01

    Biomethanation of cassava starch factory effluent in a batch digester produced 130 l biogas/kg dry matter with an average melthane content of 59%. About 63% COD was removed during 60 days. In semicontinuous digesters, gas production was 3251/kg dry matter with a retention time of 33,3 days giving a COD reduction of 50%. Size of starter inoculum was important for good biogasification of the effluent.

  10. New Physics Results from the B Factories

    SciTech Connect

    Sangro, Riccardo de

    2010-02-10

    We present a review of some recent experimental searches for new physics effects in precision flavour physics measurements performed at B factories. Recent results on selected leptonic, semi-leptonic and hadronic charm-less B decay channels studied by the BaBar and Belle collaborations will be presented and their implication within the framework of model extensions of the Standard Model will be discussed.

  11. The impact of exogenous ω-6 and ω-3 polyunsaturated fatty acids on the induced production of pro- and anti-inflammatory prostaglandins and leukotrienes in Atlantic salmon head kidney cells using a full factorial design and LC-MS/MS.

    PubMed

    Araujo, Pedro; Lucena, Eva; Yang, Yang; Ceemala, Bupesh; Mengesha, Zebasil; Holen, Elisabeth

    2014-08-01

    The production of prostaglandins (PGE2, PGE3) and leukotrienes (LTB4, LTB5) in salmon head kidney cell cultures, exposed to different combinations of 20:4ω-6, 20:5ω-3 and 22:6ω-3 polyunsaturated fatty acids (PUFAs), was evaluated by means of a two level factorial design and LC-MS/MS. The method was selective for the pro- and anti-inflammatory analytes and their corresponding stable-isotope labelled internal standards. The regression models were linear over the concentration range 0.5-150 ng/ml with limits of detection of 0.25 ng/ml and quantification of 0.40 ng/ml for the analysed metabolites. The recovery ranged from 78 to 107% for prostaglandins and 73 to 115% for leukotrienes. The analysis of the samples exposed to different combinations of PUFAs revealed that the presence of single ω-3 PUFAs brought an enhancement of the metabolites from the lipooxygenase pathway, specially LTB4, and a reduction of the metabolites from the cyclooxygenase pathway (PGE2 and PGE3), while the two-term interactions generated the opposite effect (high concentration of prostaglandins and low concentrations of leukotrienes). To our knowledge, this is the first implementation of a fully crossed design for investigating the impact of ω-6 and ω-3 PUFAs on the production of eicosanoids not only through their individual but also through their combined effects on Atlantic salmon head kidney cells.

  12. Reducing backgrounds in the higgs factory muon collider detector

    SciTech Connect

    Mokhov, N. V.; Tropin, I. S.

    2014-06-01

    A preliminary design of the 125-GeV Higgs Factory (HF) Muon Collider (MC) has identified an enormous background loads on the HF detector. This is related to the twelve times higher muon decay probability at HF compared to that previously studied for the 1.5-TeV MC. As a result of MARS15 optimization studies, it is shown that with a carefully designed protection system in the interaction region, in the machine-detector interface and inside the detector one can reduce the background rates to a manageable level similar to that achieved for the optimized 1.5-TeV case. The main characteristics of the HF detector background are presented for the configuration found.

  13. Last Year of PEP-II B-Factory Operation

    SciTech Connect

    Seeman, J.; /SLAC

    2011-11-02

    The PEP-II B-Factory at SLAC (3.1 GeV e{sup +} x 9.0 GeV e{sup -}) operated from 1999 to 2008, delivering luminosity to the BaBar experiment. The design luminosity was reached after one and a half years of operation. In the end PEP-II surpassed by four times its design luminosity reaching 1.21 x 10{sup 34} cm{sup -2} s{sup -1}. It also set stored beam current records of 2.1 A e{sup -} and 3.2 A e{sup +}. Continuous injection was implemented with BaBar taking data. The total delivered luminosity to the BaBar detector was 557.4 fb{sup -1} spanning five upsilon resonances. PEP-II was constructed by SLAC, LBNL, and LLNL with help from BINP, IHEP, the BaBar collaboration, and the US DOE OHEP.

  14. Brief Motivational and Parent Interventions for College Students: A Randomized Factorial Study

    ERIC Educational Resources Information Center

    Wood, Mark D.; Fairlie, Anne M.; Fernandez, Anne C.; Borsari, Brian; Capone, Christy; Laforge, Robert; Carmona-Barros, Rosa

    2010-01-01

    Objective: Using a randomized factorial design, we examined the efficacy of a brief motivational intervention (BMI) and a parent-based intervention (PBI) as universal preventive interventions to reduce alcohol use among incoming college students. Method: Participants (N = 1,014) were assessed prior to matriculation and at 10 months and 22 months…

  15. A Market-Based Approach to Multi-factory Scheduling

    NASA Astrophysics Data System (ADS)

    Vytelingum, Perukrishnen; Rogers, Alex; MacBeth, Douglas K.; Dutta, Partha; Stranjak, Armin; Jennings, Nicholas R.

    In this paper, we report on the design of a novel market-based approach for decentralised scheduling across multiple factories. Specifically, because of the limitations of scheduling in a centralised manner - which requires a center to have complete and perfect information for optimality and the truthful revelation of potentially commercially private preferences to that center - we advocate an informationally decentralised approach that is both agile and dynamic. In particular, this work adopts a market-based approach for decentralised scheduling by considering the different stakeholders representing different factories as self-interested, profit-motivated economic agents that trade resources for the scheduling of jobs. The overall schedule of these jobs is then an emergent behaviour of the strategic interaction of these trading agents bidding for resources in a market based on limited information and their own preferences. Using a simple (zero-intelligence) bidding strategy, we empirically demonstrate that our market-based approach achieves a lower bound efficiency of 84%. This represents a trade-off between a reasonable level of efficiency (compared to a centralised approach) and the desirable benefits of a decentralised solution.

  16. Status of neutrino factory and muon collider R and D

    SciTech Connect

    Zisman, M.S.

    2001-06-17

    A significant worldwide R and D effort is presently directed toward solving the technical challenges of producing, cooling, accelerating, storing, and eventually colliding beams of muons. Its primary thrust is toward issues critical to a Neutrino Factory, for which R and D efforts are under way in the U.S., via the Neutrino Factory and Muon Collider Collaboration (MC); in Europe, centered at CERN; and in Japan, at KEK. Under study and experimental development are production targets handling intense proton beams (1-4 MW), phase rotation systems to reduce beam energy spread, cooling channels to reduce transverse beam emittance for the acceleration system, and storage rings where muon decays in a long straight section provide a neutrino beam for a long-baseline (3000 km) experiment. Critical experimental activities include development of very high gradient normal conducting RF (NCRF) and superconducting RF (SCRF) cavities, high-power liquid-hydrogen absorbers, and high-field superconducting solenoids. Components and instrumentation that tolerate the intense decay products of the muon beam are being developed for testing. For a high-luminosity collider, muons must be cooled longitudinally as well as transversely, requiring an emittance exchange scheme. In addition to the experimental R and D effort, sophisticated theoretical and simulation tools are needed for the design. Here, the goals, present status, and future R and D plans in these areas will be described.

  17. The 9-item Bergen Burnout Inventory: factorial validity across organizations and measurements of longitudinal data.

    PubMed

    Feldt, Taru; Rantanen, Johanna; Hyvönen, Katriina; Mäkikangas, Anne; Huhtala, Mari; Pihlajasaari, Pia; Kinnunen, Ulla

    2014-01-01

    The present study tested the factorial validity of the 9-item Bergen Burnout Inventory (BBI-9). The BBI-9 is comprised of three core dimensions: (1) exhaustion at work; (2) cynicism toward the meaning of work; and (3) sense of inadequacy at work. The study further investigated whether the three-factor structure of the BBI-9 remains the same across different organizations (group invariance) and measurement time points (time invariance). The factorial group invariance was tested using a cross-sectional design with data pertaining to managers (n=742), and employees working in a bank (n=162), an engineering office (n=236), a public sector organization divided into three service areas: administration (n=102), education and culture (n=581), and social affairs and health (n=1,505). Factorial time invariance was tested using longitudinal data pertaining to managers, with three measurements over a four-year follow-up period. The confirmatory factor analysis revealed that the three-factor structure of the BBI-9 was invariant across cross-sectional samples. The factorial invariance was also supported across measurement times. To conclude, the factorial structure of the BBI-9 was found to remain the same regardless of the sample properties and measurement times.

  18. The 9-item Bergen Burnout Inventory: Factorial Validity Across Organizations and Measurements of Longitudinal Data

    PubMed Central

    Feldt, Taru; RANTANEN, Johanna; HYVÖNEN, Katriina; MÄKIKANGAS, Anne; HUHTALA, Mari; PIHLAJASAARI, Pia; KINNUNEN, Ulla

    2013-01-01

    The present study tested the factorial validity of the 9-item Bergen Burnout Inventory (BBI-9)1). The BBI-9 is comprised of three core dimensions: (1) exhaustion at work; (2) cynicism toward the meaning of work; and (3) sense of inadequacy at work. The study further investigated whether the three-factor structure of the BBI-9 remains the same across different organizations (group invariance) and measurement time points (time invariance). The factorial group invariance was tested using a cross-sectional design with data pertaining to managers (n=742), and employees working in a bank (n=162), an engineering office (n=236), a public sector organization divided into three service areas: administration (n=102), education and culture (n=581), and social affairs and health (n=1,505). Factorial time invariance was tested using longitudinal data pertaining to managers, with three measurements over a four-year follow-up period. The confirmatory factor analysis revealed that the three-factor structure of the BBI-9 was invariant across cross-sectional samples. The factorial invariance was also supported across measurement times. To conclude, the factorial structure of the BBI-9 was found to remain the same regardless of the sample properties and measurement times. PMID:24366535

  19. Industrial systems biology and its impact on synthetic biology of yeast cell factories.

    PubMed

    Fletcher, Eugene; Krivoruchko, Anastasia; Nielsen, Jens

    2016-06-01

    Engineering industrial cell factories to effectively yield a desired product while dealing with industrially relevant stresses is usually the most challenging step in the development of industrial production of chemicals using microbial fermentation processes. Using synthetic biology tools, microbial cell factories such as Saccharomyces cerevisiae can be engineered to express synthetic pathways for the production of fuels, biopharmaceuticals, fragrances, and food flavors. However, directing fluxes through these synthetic pathways towards the desired product can be demanding due to complex regulation or poor gene expression. Systems biology, which applies computational tools and mathematical modeling to understand complex biological networks, can be used to guide synthetic biology design. Here, we present our perspective on how systems biology can impact synthetic biology towards the goal of developing improved yeast cell factories. Biotechnol. Bioeng. 2016;113: 1164-1170. © 2015 Wiley Periodicals, Inc.

  20. Methods for economic evaluation of a factorial-design cluster randomised controlled trial of a nutrition supplement and an exercise programme among healthy older people living in Santiago, Chile: the CENEX study

    PubMed Central

    Walker, Damian G; Aedo, Cristian; Albala, Cecilia; Allen, Elizabeth; Dangour, Alan D; Elbourne, Diana; Grundy, Emily; Uauy, Ricardo

    2009-01-01

    Background In an effort to promote healthy ageing and preserve health and function, the government of Chile has formulated a package of actions into the Programme for Complementary Food in Older People (Programa de Alimentación Complementaria para el Adulto Mayor - PACAM). The CENEX study was designed to evaluate the impact, cost and cost-effectiveness of the PACAM and a specially designed exercise programme on pneumonia incidence, walking capacity and body mass index in healthy older people living in low- to medium-socio-economic status areas of Santiago. The purpose of this paper is to describe in detail the methods that will be used to estimate the incremental costs and cost-effectiveness of the interventions. Methods and design The base-case analysis will adopt a societal perspective, including the direct medical and non-medical costs borne by the government and patients. The cost of the interventions will be calculated by the ingredients approach, in which the total quantities of goods and services actually employed in applying the interventions will be estimated, and multiplied by their respective unit prices. Relevant information on costs of interventions will be obtained mainly from administrative records. The costs borne by patients will be collected via exit and telephone interviews. An annual discount rate of 8% will be used, consistent with the rate recommended by the Government of Chile. All costs will be converted from Chilean Peso to US dollars with the 2007 average period exchange rate of US$1 = 522.37 Chilean Peso. To test the robustness of model results, we will vary the assumptions over a plausible range in sensitivity analyses. Discussion The protocol described here indicates our intent to conduct an economic evaluation alongside the CENEX study. It provides a detailed and transparent statement of planned data collection methods and analyses. Trial registration ISRCTN48153354 PMID:19473513

  1. Optimization of a novel method for determination of benzene, toluene, ethylbenzene, and xylenes in hair and waste water samples by carbon nanotubes reinforced sol-gel based hollow fiber solid phase microextraction and gas chromatography using factorial experimental design.

    PubMed

    Es'haghi, Zarrin; Ebrahimi, Mahmoud; Hosseini, Mohammad-Saeid

    2011-05-27

    A novel design of solid phase microextraction fiber containing carbon nanotube reinforced sol-gel which was protected by polypropylene hollow fiber (HF-SPME) was developed for pre-concentration and determination of BTEX in environmental waste water and human hair samples. The method validation was included and satisfying results with high pre-concentration factors were obtained. In the present study orthogonal array experimental design (OAD) procedure with OA(16) (4(4)) matrix was applied to study the effect of four factors influencing the HF-SPME method efficiency: stirring speed, volume of adsorption organic solvent, extraction and desorption time of the sample solution, by which the effect of each factor was estimated using individual contributions as response functions in the screening process. Analysis of variance (ANOVA) was employed for estimating the main significant factors and their percentage contributions in extraction. Calibration curves were plotted using ten spiking levels of BTEX in the concentration ranges of 0.02-30,000ng/mL with correlation coefficients (r) 0.989-0.9991 for analytes. Under the optimized extraction conditions, the method showed good linearity (0.3-20,000ng/L), repeatability, low limits of detections (0.49-0.7ng/L) and excellent pre-concentration factors (185-1872). The best conditions which were estimated then applied for the analysis of BTEX compounds in the real samples.

  2. In-Factory Learning - Qualification For The Factory Of The Future

    NASA Astrophysics Data System (ADS)

    Quint, Fabian; Mura, Katharina; Gorecky, Dominic

    2015-07-01

    The Industry 4.0 vision anticipates that internet technologies will find their way into future factories replacing traditional components by dynamic and intelligent cyber-physical systems (CPS) that combine the physical objects with their digital representation. Reducing the gap between the real and digital world makes the factory environment more flexible, more adaptive, but also more complex for the human workers. Future workers require interdisciplinary competencies from engineering, information technology, and computer science in order to understand and manage the diverse interrelations between physical objects and their digital counterpart. This paper proposes a mixed-reality based learning environment, which combines physical objects and visualisation of digital content via Augmented Reality. It uses reality-based interaction in order to make the dynamic interrelations between real and digital factory visible and tangible. We argue that our learning system does not work as a stand-alone solution, but should fit into existing academic and advanced training curricula.

  3. A Distribution-Free Multi-Factorial Profiler for Harvesting Information from High-Density Screenings

    PubMed Central

    Besseris, George J.

    2013-01-01

    Data screening is an indispensable phase in initiating the scientific discovery process. Fractional factorial designs offer quick and economical options for engineering highly-dense structured datasets. Maximum information content is harvested when a selected fractional factorial scheme is driven to saturation while data gathering is suppressed to no replication. A novel multi-factorial profiler is presented that allows screening of saturated-unreplicated designs by decomposing the examined response to its constituent contributions. Partial effects are sliced off systematically from the investigated response to form individual contrasts using simple robust measures. By isolating each time the disturbance attributed solely to a single controlling factor, the Wilcoxon-Mann-Whitney rank stochastics are employed to assign significance. We demonstrate that the proposed profiler possesses its own self-checking mechanism for detecting a potential influence due to fluctuations attributed to the remaining unexplainable error. Main benefits of the method are: 1) easy to grasp, 2) well-explained test-power properties, 3) distribution-free, 4) sparsity-free, 5) calibration-free, 6) simulation-free, 7) easy to implement, and 8) expanded usability to any type and size of multi-factorial screening designs. The method is elucidated with a benchmarked profiling effort for a water filtration process. PMID:24009744

  4. Application of carbon nanotubes modified with a Keggin polyoxometalate as a new sorbent for the hollow-fiber micro-solid-phase extraction of trace naproxen in hair samples with fluorescence spectrophotometry using factorial experimental design.

    PubMed

    Naddaf, Ezzat; Ebrahimi, Mahmoud; Es'haghi, Zarrin; Bamoharram, Fatemeh Farrash

    2015-07-01

    A sensitive technique to determinate naproxen in hair samples was developed using hollow-fiber micro-solid-phase combined with fluorescence spectrophotometry. The incorporation of multi-walled carbon nanotubes modified with a Keggin polyoxometalate into a silica matrix prepared by the sol-gel method was reported. In this research, the Keggin carbon nanotubes /silica composite was used in the pores and lumen of a hollow fiber as the hollow-fiber micro-solid-phase extraction device. The device was used for the microextraction of the analyte from hair and water samples under the optimized conditions. An orthogonal array experimental design with an OA24 (4(6) ) matrix was employed to optimize the conditions. The effect of six factors influencing the extraction efficiency was investigated: pH, salt, volume of donor and desorption phase, extraction and desorption time. The effect of each factor was estimated using individual contributions as response functions in the screening process. Analysis of variance was employed for estimating the main significant factors and their contributions in the extraction. Calibration curve plot displayed linearity over a range of 0.2-10 ng/mL with detection limits of 0.072 and 0.08 ng/mL for hair and aqueous samples, respectively. The relative recoveries in the hair and aqueous matrices ranged from 103-95%. The relative standard deviation for fiber-to-fiber repeatability was 3.9%. PMID:25931376

  5. Application of carbon nanotubes modified with a Keggin polyoxometalate as a new sorbent for the hollow-fiber micro-solid-phase extraction of trace naproxen in hair samples with fluorescence spectrophotometry using factorial experimental design.

    PubMed

    Naddaf, Ezzat; Ebrahimi, Mahmoud; Es'haghi, Zarrin; Bamoharram, Fatemeh Farrash

    2015-07-01

    A sensitive technique to determinate naproxen in hair samples was developed using hollow-fiber micro-solid-phase combined with fluorescence spectrophotometry. The incorporation of multi-walled carbon nanotubes modified with a Keggin polyoxometalate into a silica matrix prepared by the sol-gel method was reported. In this research, the Keggin carbon nanotubes /silica composite was used in the pores and lumen of a hollow fiber as the hollow-fiber micro-solid-phase extraction device. The device was used for the microextraction of the analyte from hair and water samples under the optimized conditions. An orthogonal array experimental design with an OA24 (4(6) ) matrix was employed to optimize the conditions. The effect of six factors influencing the extraction efficiency was investigated: pH, salt, volume of donor and desorption phase, extraction and desorption time. The effect of each factor was estimated using individual contributions as response functions in the screening process. Analysis of variance was employed for estimating the main significant factors and their contributions in the extraction. Calibration curve plot displayed linearity over a range of 0.2-10 ng/mL with detection limits of 0.072 and 0.08 ng/mL for hair and aqueous samples, respectively. The relative recoveries in the hair and aqueous matrices ranged from 103-95%. The relative standard deviation for fiber-to-fiber repeatability was 3.9%.

  6. Diamond Growth in the Subduction Factory

    NASA Astrophysics Data System (ADS)

    Bureau, H.; Frost, D. J.; Bolfan-Casanova, N.; Leroy, C.; Estève, I.

    2014-12-01

    Natural diamonds are fabulous probes of the deep Earth Interior. They are the evidence of the deep storage of volatile elements, carbon at first, but also hydrogen and chlorine trapped as hydrous fluids in inclusions. The study of diamond growth processes in the lithosphere and mantle helps for our understanding of volatile elements cycling between deep reservoirs. We know now that inclusion-bearing diamonds similar to diamonds found in nature (i.e. polycrystalline, fibrous and coated diamonds) can grow in hydrous fluids or melts (Bureau et al., GCA 77, 202-214, 2012). Therefore, we propose that the best environment to promote such diamonds is the subduction factory, where highly hydrous fluids or melts are present. When oceanic plates are subducted in the lithosphere, they carry an oceanic crust soaked with seawater. While the slabs are traveling en route to the mantle, dehydration processes generate saline fluids highly concentrated in NaCl. In the present study we have experimentally shown that diamonds can grow from the saline fluids (up to 30 g/l NaCl in water) generated in subducted slabs. We have performed multi-anvil press experiments at 6-7 GPa and from 1300 to 1400°C during 6:00 hours to 30:00 hours. We observed large areas of new diamond grown in epitaxy on pure diamond seeds in salty hydrous carbonated melts, forming coated gems. The new rims are containing multi-component primary inclusions. Detailed characterizations of the diamonds and their inclusions have been performed and will be presented. These experimental results suggest that multi-component salty fluids of supercritical nature migrate with the slabs, down to the deep mantle. Such fluids may insure the first stage of the deep Earth's volatiles cycling (C, H, halogen elements) en route to the transition zone and the lower mantle. We suggest that the subduction factory may also be a diamond factory.

  7. Object classification at the Nearby Supernova Factory

    NASA Astrophysics Data System (ADS)

    Bailey, S.; Aragon, C.; Romano, R.; Thomas, R. C.; Weaver, B. A.; Wong, D.

    2008-03-01

    We present the results of applying new object classification techniques to the supernova search of the Nearby Supernova Factory. In comparison to simple threshold cuts, more sophisticated methods such as boosted decision trees, random forests, and support vector machines provide dramatically better object discrimination: we reduced the number of non-supernova candidates by a factor of 10 while increasing our supernova identification efficiency. Methods such as these will be crucial for maintaining a reasonable false positive rate in the automated transient alert pipelines of upcoming large optical surveys.

  8. Object Classification at the Nearby Supernova Factory

    SciTech Connect

    Aragon, Cecilia R.; Bailey, Stephen; Aragon, Cecilia R.; Romano, Raquel; Thomas, Rollin C.; Weaver, B. A.; Wong, D.

    2007-12-21

    We present the results of applying new object classification techniques to the supernova search of the Nearby Supernova Factory. In comparison to simple threshold cuts, more sophisticated methods such as boosted decision trees, random forests, and support vector machines provide dramatically better object discrimination: we reduced the number of nonsupernova candidates by a factor of 10 while increasing our supernova identification efficiency. Methods such as these will be crucial for maintaining a reasonable false positive rate in the automated transient alert pipelines of upcoming large optical surveys.

  9. Survey and Alignment of SLAC's B Factory

    SciTech Connect

    Pietryka, Matthew J.; Gaydosh, Michael L.; /SLAC

    2011-09-08

    The survey and alignment of SLAC's B-factory injector and high energy ring will be complete in March 1997. Modern digital electronic surveying tools are contributing to new, efficient alignment procedures. A laser tracker was used to fiducialize almost 300 quadrupole magnets. Digital levels were used to pre-set base plate elevations. Theodolites with very accurate co-axial distance meters were used for everything from layout to 3D magnet positioning to network surveys, all in free stationing mode. A number of procedures and measurement results are outlined.

  10. The Personal Software Process: Downscaling the factory

    NASA Technical Reports Server (NTRS)

    Roy, Daniel M.

    1994-01-01

    It is argued that the next wave of software process improvement (SPI) activities will be based on a people-centered paradigm. The most promising such paradigm, Watts Humphrey's personal software process (PSP), is summarized and its advantages are listed. The concepts of the PSP are shown also to fit a down-scaled version of Basili's experience factory. The author's data and lessons learned while practicing the PSP are presented along with personal experience, observations, and advice from the perspective of a consultant and teacher for the personal software process.

  11. Wake Fields in the Super B Factory Interaction Region

    SciTech Connect

    Weathersby, Stephen; Novokhatski, Alexander; /SLAC

    2011-06-02

    The geometry of storage ring collider interaction regions present an impedance to beam fields resulting in the generation of additional electromagnetic fields (higher order modes or wake fields) which affect the beam energy and trajectory. These affects are computed for the Super B interaction region by evaluating longitudinal loss factors and averaged transverse kicks for short range wake fields. Results indicate at least a factor of 2 lower wake field power generation in comparison with the interaction region geometry of the PEP-II B-factory collider. Wake field reduction is a consderation in the Super B design. Transverse kicks are consistent with an attractive potential from the crotch nearest the beam trajectory. The longitudinal loss factor scales as the -2.5 power of the bunch length. A factor of 60 loss factor reduction is possible with crotch geometry based on an intersecting tubes model.

  12. Accelerator R&D toward Muon Collider and Neutrino Factory

    NASA Astrophysics Data System (ADS)

    Shiltsev, V.

    2010-12-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture, accelerate and collide high intensity beams of muons. At present, a high-luminosity multi-TeV muon collider presents a viable option for the next generation lepton-lepton collider, which is believed to be needed to fully explore high energy physics in the era following LHC discoveries. Such a collider can offer superb energy resolution, smaller size, and potentially cost and power consumption compared to multi-TeV e + e - linear colliders. This article briefly reviews the motivation, design and status of accelerator R&D for Muon Collider and Neutrino Factory.

  13. Formulation of wax oxybenzone microparticles using a factorial approach.

    PubMed

    Gomaa, Y A; Darwish, I A; Boraei, N A; El-Khordagui, L K

    2010-01-01

    Oxybenzone wax microparticles (MPs) were prepared by the hydrophobic congealable disperse phase method. The formulation of oxybenzone-loaded MPs was optimized using a 2⁴ experimental design. Factorial analysis indicated that the main MP characteristics were influenced by initial drug loading, emulsification speed, emulsifier concentration and hydrophilic-lipophilic balance. MPs were spherical with 50.5–88.1 μm size range, 17.8–38.9 drug content in mg/100 mg MPs and 33.1–87.2% oxybenzone release in 1 h. A wide range of sunscreen delivery systems suitable for different formulation purposes were generated which may contribute to the advanced formulation of sunscreen products with improved performance. PMID:20681744

  14. Formulation of wax oxybenzone microparticles using a factorial approach.

    PubMed

    Gomaa, Y A; Darwish, I A; Boraei, N A; El-Khordagui, L K

    2010-01-01

    Oxybenzone wax microparticles (MPs) were prepared by the hydrophobic congealable disperse phase method. The formulation of oxybenzone-loaded MPs was optimized using a 2⁴ experimental design. Factorial analysis indicated that the main MP characteristics were influenced by initial drug loading, emulsification speed, emulsifier concentration and hydrophilic-lipophilic balance. MPs were spherical with 50.5–88.1 μm size range, 17.8–38.9 drug content in mg/100 mg MPs and 33.1–87.2% oxybenzone release in 1 h. A wide range of sunscreen delivery systems suitable for different formulation purposes were generated which may contribute to the advanced formulation of sunscreen products with improved performance.

  15. Bronchodilators for treatment of mild bronchiolitis: a factorial randomised trial.

    PubMed Central

    Wang, E E; Milner, R; Allen, U; Maj, H

    1992-01-01

    A randomised double blind trial was conducted to determine the efficacy of inhaled bronchodilators, salbutamol and ipratropium bromide, compared with placebo in the treatment of bronchiolitis. Patients, who were 2 months to 2 years of age and without underlying cardiac or pulmonary disease, received drug 1 (salbutamol or saline placebo) followed one hour later by drug 2 (ipratropium bromide or placebo). Both agents were administered every four hours. The patients were allocated to one of four groups according to a factorial design. The four groups were similar in demographic characteristics, initial oxygenation, and clinical score. The change in oxygen saturation of recipients of both agents was significantly better than that of recipients of salbutamol alone or ipratropium bromide alone. This change, however, was not statistically different from that of the control group. No difference was observed in the clinical score or hospital duration. Inhaled bronchodilators did not improve the condition of hospitalised mild bronchiolitis. PMID:1533504

  16. Feasibility Study for an Asymmetric B Factory Based on PEP

    SciTech Connect

    Chattapadhyay, A.; Hitlin, D.; Porter, F.; Chin, Y.H.; Dell'Orco, D.; Forest, E.; Furman, M.; Garren, A.A.; Hoyer, E.; Kennedy, K.; Lambertson, G.; Lo, C.C.; Nishimura, H.; Oddone, P.; Ronan, M.; Sessler, A.; Taylor, B.; Taylor, C.; Zisman, M.; Barletta, W.; Allen, M.; Bloom, E.; Burke, D.; Cornacchia, M.; Davies-White, D.; Destaebler, H.; Donald, M.H.; Dorfan, J.; Feldman, G.; Rees, J.; Schsarz, H.; Sullivan, M.; Autin, B.; Tennyson, J.; Barbson, B.; Oide, K.

    1989-10-26

    This report addresses the feasibility of designing and constructing an asymmetric B-factory based on the PEP storage ring at SLAC that can ultimately reach a luminosity of 1 X 10{sup 34} cm{sup -2}s{sup -1}. Such a facility, operating at the {gamma}(4S) resonance, could be used to study mixing, rate decays, and CP violation in the B{bar B} system, and could also study tau and charm physics. The essential accelerator physics, engineering, and technology issues that must be addressed to successfully build this exciting and challenging facility are identified, and possible solutions, or R and D that will reasonable lead to such solutions, are described.

  17. Accelerator R&D toward Muon Collider and Neutrino Factory

    SciTech Connect

    Shiltsev, Vladimir; /Fermilab

    2009-10-01

    Over the last decade there has been significant progress in developing the concepts and technologies needed to produce, capture, accelerate and collide high intensity beams of muons. At present, a high-luminosity multi-TeV muon collider presents a viable option for the next generation lepton-lepton collider, which is believed to be needed to fully explore high energy physics in the era following LHC discoveries. Such a collider can offer superb energy resolution, smaller size, and potentially cost and power consumption compared to multi-TeV e{sup +}e{sup -} linear colliders. This article briefly reviews the motivation, design and status of accelerator R&D for Muon Collider and Neutrino Factory.

  18. Investigation of an Asymmetric B Factory in the PEP Tunnel

    SciTech Connect

    Chattapadhyay, A.; Hitlin, D.; Porter, F.; Chin, Y.H.; Dell'Orco, D.; Forest, E.; Furman, M.; Garren, A.A.; Hearty, C.; Jacob, A.; Kennedy, K.; Kim, K.; Lambertson, G.; Oddone, P.; Ronan, M.; Sessler, A.; Taylor, C.; Voelker, F.; Zisman, M.; Barletta, W.; Allen, M.; Bane, K.; Bloom, E.; Brenkus, F.; Brown, K.; Corbett, J.; Cornacchia, M.; Coupal, D.; Davies-White, W.; DeStaebler, H.; Donald, M.; Dorfan, J.; Hsu, I.; Hutton, A.; Jenkins, T.; Kozanecki, W.; Lisin, A.; Loew, G.; Miller, R.; Morton, P.; Pellegrin, J.-L.; Raubenheimer, T.; Rees, J.; Ritson, D.; Ruth, R.; Saab, A.; Savage, W.; Schwarz, H.; Seeman, J.; Thompson, K.; Weidner, H.; Wilson, P.; Sullivan, M.; Jackson, G.; Hertzbach, S.; Tennyson, J.; Zholents, A.; Fitze, H.

    1990-03-01

    This report addresses the feasibility of designing and constructing an asymmetric B-factory based on the PEP storage ring at SLAC that can begin operation at a luminosity of 3 X 10{sup 33} cm{sup -2}s{sup -1} and could ultimately reach even higher luminosity. Such a facility, operating at the {gamma}(4S) resonance, could be used to study mixing, rare decays, and CP violation in the B{bar B} system, and could also study tau and charm physics. The essential accelerator physics, engineering and technology issues that must be addressed to successfully build this exciting and challenging facility are identified, and possible solutions, or R and D activities that will reasonable lead to such solutions, are described.

  19. Parameters for a Super-Flavor-Factory

    SciTech Connect

    Seeman, J.T.; Cai, Y.; Ecklund, S.; Novokhatski, A.; Seryi, A.; Sullivan, M.; Wienands, U.; Biagini, M.; Raimondi, P.; /Frascati

    2006-06-27

    A Super Flavor Factory, an asymmetric energy e{sup +}e{sup -} collider with a luminosity of order 10{sup 36} cm{sup -2} s{sup -1}, can provide a sensitive probe of new physics in the flavor sector of the Standard Model. The success of the PEP-II and KEKB asymmetric colliders in producing unprecedented luminosity above 10{sup 34} cm{sup -2} s{sup -1} has taught us about the accelerator physics of asymmetric e{sup +}e{sup -} collider in a new parameter regime. Furthermore, the success of the SLAC Linear Collider and the subsequent work on the International Linear Collider allow a new Super-Flavor collider to also incorporate linear collider techniques. This note describes the parameters of an asymmetric Flavor-Factory collider at a luminosity of order 10{sup 36} cm{sup -2} s{sup -1} at the Y(4S) resonance and about 10{sup 35} cm{sup -2} s{sup -1} at the {tau} production threshold. Such a collider would produce an integrated luminosity of about 10,000 fb{sup -1} (10 ab{sup -1}) in a running year (10{sup 7} sec) at the Y(4S) resonance. In the following note only the parameters relative to the Y(4S) resonance will be shown, the ones relative to the lower energy operations are still under study.

  20. Quarkonium States at B-Factories

    SciTech Connect

    Robutti, Enrico; /INFN, Genoa

    2011-11-21

    An overview is given on recent progress in the study of quarkonium spectroscopy at the B-factories. In particular, an updated status report is presented of the long list of 'charmonium-like' resonances newly discovered, whose assignment as true charmonium states is in most cases at least controversial. Also, new measurements on the decay properties of bottomonium states above open-B production thresholds are shown. Much of the progress attained in recent years in the study of the quarkonium spectra is owed to the measurements performed at B-factories. The impressive amount of data recorded by the BABAR and Belle experiments has made it possible to study rare decay chains and to look for as yet undiscovered resonances in the charmonium and bottomonium mass regions. Results presented here are based on different subsamples of the full datasets recorded up to now by the two experiments, corresponding to integrated luminosities of about 430 fb{sup -1}(BABAR - final) and about 850 fb{sup -1}(Belle). Significant contributions also come from the analysis of the various data samples recorded by the CLEO detector.

  1. Carbonate factories: A conundrum in sedimentary geology

    NASA Astrophysics Data System (ADS)

    Pomar, L.; Hallock, P.

    2008-03-01

    by the end-Permian extinctions, excess photosynthesis by phytoplankton and microbial assemblages in surface waters, induced by moderately high CO 2 and temperature during the Early Mesozoic, supported proliferation of non-tissular metazoans (e.g., sponges) and heterotrophic bacteria at the sea floor. Metabolic activity by those microbes, especially sulfate reduction, resulted in abundant biologically-induced geochemical carbonate precipitation on and within the sea floor. For example, with the opening of Tethyan seaways during the Triassic, massive sponge/microbe boundstones (the benthic automicrite factory) formed steep, massive and thick progradational slopes and, locally, mud-mounds. As tectonic processes created shallow epicontinental seas, photosynthesis drove lime-mud precipitation in the illuminated zone of the water column. The resulting neritic lime-mud component of the shallow-water carbonate factory became predominant during the Jurassic, paralleling the increase in atmospheric pCO 2, while the decreasing importance of the benthic automicrite factory parallels the diversification of calcifying metazoans, phytoplankton and zooplankton. With atmospheric pCO 2 declining through the Cretaceous, the potential habitats for neritic lime-mud precipitation declined. At the same time, peak oceanic Ca 2+ concentrations promoted biotically-controlled calcification by the skeletal factory. With changes produced by extinctions and turnovers at the Cretaceous-Tertiary boundary, adaptations to decreasing Ca 2+ and pCO 2, coupled with increasing global temperature gradients (i.e., high-latitude and deep-water cooling), and strategies that efficiently linked photosynthesis and calcification, promoted successive changes of the dominant skeletal factory through the Cenozoic: larger benthic foraminifers (protist-protist symbiosis) during the Paleogene, red algae during the Miocene and modern coral reefs (metazoan-protist symbiosis) since Late Miocene.

  2. Asymptotic Normality Through Factorial Cumulants and Partition Identities

    PubMed Central

    Bobecka, Konstancja; Hitczenko, Paweł; López-Blázquez, Fernando; Rempała, Grzegorz; Wesołowski, Jacek

    2013-01-01

    In the paper we develop an approach to asymptotic normality through factorial cumulants. Factorial cumulants arise in the same manner from factorial moments as do (ordinary) cumulants from (ordinary) moments. Another tool we exploit is a new identity for ‘moments’ of partitions of numbers. The general limiting result is then used to (re-)derive asymptotic normality for several models including classical discrete distributions, occupancy problems in some generalized allocation schemes and two models related to negative multinomial distribution. PMID:24591773

  3. Vacuum system of the high energy ring of an asymmetric B-factory based on PEP

    SciTech Connect

    Barletta, W.A.; Calderon, M.O.; Wong, R. ); Jenkins, T.M. )

    1991-05-07

    The multi-ampere currents required for high luminosity operation of an asymmetric B factory leads to extremely stressing requirements on a vacuum system suitable for maintaining long beam-gas lifetimes and acceptable background levels in the detector. We present the design for a Cu alloy vacuum chamber and its associated pumping system for the 9 GeV electron storage ring of the proposed B factory based on PEP. The excellent thermal and photo-desorption properties of Cu allows handling the high proton flux in a conventional, single chamber design with distributed ion pumps. The x-ray opacity of the Cu is sufficiently high that no additional lead shielding is necessary to protect the dipoles from the intense synchrotron radiation generated by the beam. The design allows chamber commissioning in <500 hr of operation. 5 refs., 3 figs., 2 tabs.

  4. Thermoluminescence curves simulation using genetic algorithm with factorial design

    NASA Astrophysics Data System (ADS)

    Popko, E. A.; Weinstein, I. A.

    2016-05-01

    The evolutionary approach is an effective optimization tool for numeric analysis of thermoluminescence (TL) processes to assess the microparameters of kinetic models and to determine its effects on the shape of TL peaks. In this paper, the procedure for tuning of genetic algorithm (GA) is presented. This approach is based on multifactorial experiment and allows choosing intrinsic mechanisms of evolutionary operators which provide the most efficient algorithm performance. The proposed method is tested by considering the “one trap-one recombination center” (OTOR) model as an example and advantages for approximation of experimental TL curves are shown.

  5. Aplastic anemia in a petrochemical factory worker.

    PubMed Central

    Baak, Y M; Ahn, B Y; Chang, H S; Kim, J H; Kim, K A; Lim, Y

    1999-01-01

    A petrochemical worker with aplastic anemia was referred to our hospital. He worked in a petroleum resin-producing factory and had been exposed to low-level benzene while packaging the powder resin and pouring lime into a deactivation tank. According to the yearly environmental survey of the working area, the airborne benzene level was approximately 0.28 ppm. Exposure to benzene, a common chemical used widely in industry, may progressively lead to pancytopenia, aplastic anemia, and leukemia. The hematotoxicity of benzene is related to the amount and duration of exposure. Most risk predictions for benzene exposures have been based on rubber workers who were exposed to high concentrations. In the petroleum industry, the concentration of benzene is relatively low, and there are disputes over the toxicity of low-level benzene because of a lack of evidence. In this paper we report the case of aplastic anemia induced by low-level benzene exposure. Images Figure 1 PMID:10504154

  6. Factorial analysis of trihalomethanes formation in drinking water.

    PubMed

    Chowdhury, Shakhawat; Champagne, Pascale; McLellan, P James

    2010-06-01

    Disinfection of drinking water reduces pathogenic infection, but may pose risks to human health through the formation of disinfection byproducts. The effects of different factors on the formation of trihalomethanes were investigated using a statistically designed experimental program, and a predictive model for trihalomethanes formation was developed. Synthetic water samples with different factor levels were produced, and trihalomethanes concentrations were measured. A replicated fractional factorial design with center points was performed, and significant factors were identified through statistical analysis. A second-order trihalomethanes formation model was developed from 92 experiments, and the statistical adequacy was assessed through appropriate diagnostics. This model was validated using additional data from the Drinking Water Surveillance Program database and was applied to the Smiths Falls water supply system in Ontario, Canada. The model predictions were correlated strongly to the measured trihalomethanes, with correlations of 0.95 and 0.91, respectively. The resulting model can assist in analyzing risk-cost tradeoffs in the design and operation of water supply systems.

  7. Rapid and high-throughput construction of microbial cell-factories with regulatory noncoding RNAs.

    PubMed

    Chaudhary, Amit Kumar; Na, Dokyun; Lee, Eun Yeol

    2015-11-01

    Due to global crises such as pollution and depletion of fossil fuels, sustainable technologies based on microbial cell-factories have been garnering great interest as an alternative to chemical factories. The development of microbial cell-factories is imperative in cutting down the overall manufacturing cost. Thus, diverse metabolic engineering strategies and engineering tools have been established to obtain a preferred genotype and phenotype displaying superior productivity. However, these tools are limited to only a handful of genes with permanent modification of a genome and significant labor costs, and this is one of the bottlenecks associated with biofactory construction. Therefore, a groundbreaking rapid and high-throughput engineering tool is needed for efficient construction of microbial cell-factories. During the last decade, copious small noncoding RNAs (ncRNAs) have been discovered in bacteria. These are involved in substantial regulatory roles like transcriptional and post-transcriptional gene regulation by modulating mRNA elongation, stability, or translational efficiency. Because of their vulnerability, ncRNAs can be used as another layer of conditional control over gene expression without modifying chromosomal sequences, and hence would be a promising high-throughput tool for metabolic engineering. Here, we review successful design principles and applications of ncRNAs for high-throughput metabolic engineering or physiological studies of diverse industrially important microorganisms. PMID:26027891

  8. Parametric study of a target factory for laser fusion

    SciTech Connect

    Sherohman, J.W.; Meier, W.R.

    1980-10-08

    An analysis of a target factory leading to the derivation of production rate equations has provided the basis for a parametric study. Rate equations describing the production of laser fusion targets have been developed for the purpose of identifying key parameters, attractive production techniques and cost scaling relationships for a commercial target factory.

  9. 13. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING SOUTHEAST. THIS SECTION OF THE FACTORY WAS USED FOR STORAGE; TO THE LEFT IS AN ELECTRIC MOTOR SUSPENDED FROM A COLLAR BEAM. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  10. 11. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING NORTHWEST. THIS SECTION OF THE FACTORY WAS USED FOR STORAGE; THE STAIRWAY LEADS DOWN TO THE SECOND FLOOR WHICH WAS THE LOCATION OF THE COMPANY OFFICE AND EMPLOYEE CHANGE ROOM. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  11. 12. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. INTERIOR VIEW OF THIRD FLOOR OF ORIGINAL FACTORY, LOOKING NORTHEAST. THIS SECTION OF THE FACTORY WAS USED FOR STORAGE; CENTRAL LINE SHAFTING EXTENDS ALONG THE CENTER ROW OF COLUMNS. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  12. 37. NORTH TO BINS ALONG NORTH WALL OF FACTORY BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. NORTH TO BINS ALONG NORTH WALL OF FACTORY BUILDING WHICH REMAIN FILLED WITH NEW OLD STOCK AND USED PARTS FOR ELI WINDMILLS. THE ROPE AT THE LOWER FOREGROUND WAS USED IN ERECTING WINDMILLS AND TOWERS FOR CUSTOMERS. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  13. 27 CFR 40.47 - Other businesses within factory.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2012-04-01 2011-04-01 true Other businesses within... AND TUBES, AND PROCESSED TOBACCO Administrative Provisions § 40.47 Other businesses within factory. (a) General. The appropriate TTB officer may authorize such other businesses within the factory of...

  14. 27 CFR 40.47 - Other businesses within factory.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2014-04-01 2014-04-01 false Other businesses within... AND TUBES, AND PROCESSED TOBACCO Administrative Provisions § 40.47 Other businesses within factory. (a) General. The appropriate TTB officer may authorize such other businesses within the factory of...

  15. Students Tackle Academics in Practical Context at Skateboard Factory

    ERIC Educational Resources Information Center

    Pearson, George

    2012-01-01

    High school student Nick Robertson came to Oasis Skateboard Factory (OSF) from a suburban Toronto district. He was surfing the web when he spotted a reference to Oasis Skateboard Factory, an alternative program in the Toronto District School Board. He says his first reaction was "Skateboards in school? It didn't seem possible." He applied, was…

  16. Perspective view. Fivestory reinforced concrete factory building reveals the structural ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Perspective view. Five-story reinforced concrete factory building reveals the structural frame on the exterior of the facade. Twelve bay facade facing onto Clay Avenue (north facade) has first floor openings bricked up. Mix of typical factory windows and glass block windows fill the majority of the openings on the rest of building - Russell Industrial Center, 1600 Clay Avenue, Detroit, MI

  17. Factorial Invariance in Multiple Populations: A Multiple Testing Procedure

    ERIC Educational Resources Information Center

    Raykov, Tenko; Marcoulides, George A.; Millsap, Roger E.

    2013-01-01

    A multiple testing method for examining factorial invariance for latent constructs evaluated by multiple indicators in distinct populations is outlined. The procedure is based on the false discovery rate concept and multiple individual restriction tests and resolves general limitations of a popular factorial invariance testing approach. The…

  18. Factorial Invariance of a Pan-Hispanic Familism Scale

    ERIC Educational Resources Information Center

    Villarreal, Ricardo; Blozis, Shelley A.; Widaman, Keith F.

    2005-01-01

    This article considers the validity and factorial invariance of an attitudinal measure of familism. Using a large, nationally representative sample of U.S. Hispanics, the validity and factorial invariance of the measure was tested across country of origin (United States, Mexico, and Latin America) and the language in which the survey was conducted…

  19. 1. Aerial photograph of the Quaker Oats Cereal Factory looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Aerial photograph of the Quaker Oats Cereal Factory looking east to west. Structures included in this complex situated on the east side of Broadway Street between Bowery Street and Mill Street range in date of original use from 1886 to 1940. - Quaker Oats Cereal Factory, Southeast corner of Broadway & Mill Streets, Akron, Summit County, OH

  20. 2. Aerial photograph of the Quaker Oats Cereal Factory looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Aerial photograph of the Quaker Oats Cereal Factory looking west to east. Structures included in this complex situated on the east side of Broadway Street between Bowery Street and Mill Street range in date of original use from 1886 to 1940. - Quaker Oats Cereal Factory, Southeast corner of Broadway & Mill Streets, Akron, Summit County, OH

  1. Advanced Envelope Research for Factory Built Housing, Phase 3. Whole-House Prototyping

    SciTech Connect

    Levy, E.; Mullens, M.; Rath, P.

    2014-04-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective envelope designs that can be effectively integrated into the plant production process while meeting the thermal requirements of the 2012 IECC standards. This work is part of a multiphase effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three methods for building high performance walls. Phase 2 focused on developing viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped narrow the research focus to perfecting a stud wall design with exterior continuous insulation (CI). This report describes Phase 3, which was completed in two stages and continued the design development effort, exploring and evaluating a range or methods for applying CI to factory built homes. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing. During this phase, a home was built with CI, evaluated, and placed in service. The experience of building a mock up wall section with CI and then constructing on line a prototype home resolved important concerns about how to integrate the material into the production process. First steps were taken toward finding least expensive approaches for incorporating CI in standard factory building practices and a preliminary assessment suggested that even at this early stage the technology is attractive when viewed from a life cycle cost perspective.

  2. Advanced Envelope Research for Factory Built Housing, Phase 3 -- Whole-House Prototyping

    SciTech Connect

    Levy, E.; Mullens, M.; Rath, P.

    2014-04-01

    The Advanced Envelope Research effort will provide factory homebuilders with high performance, cost-effective envelope designs that can be effectively integrated into the plant production process while meeting the thermal requirements of the 2012 IECC standards. Given the affordable nature of manufactured homes, impact on first cost is a major consideration in developing new envelope technologies. This work is part of a multi-phase effort. Phase 1 identified seven envelope technologies and provided a preliminary assessment of three methods for building high performance walls. Phase 2 focused on developing viable product designs, manufacturing strategies, addressing code and structural issues, and cost analysis of the three selected options. An industry advisory committee helped narrow the research focus to perfecting a stud wall design with exterior continuous insulation (CI). Phase 3, completed in two stages, continued the design development effort, exploring and evaluating a range or methods for applying CI to factory built homes. The scope also included material selection, manufacturing and cost analysis, and prototyping and testing. During this phase, a home was built with CI, evaluated, and placed in service. The experience of building a mock up wall section with CI and then constructing on line a prototype home resolved important concerns about how to integrate the material into the production process. First steps were taken toward finding least expensive approaches for incorporating CI in standard factory building practices and a preliminary assessment suggested that even at this early stage the technology is attractive when viewed from a life cycle cost perspective.

  3. Touschek Background and Lifetime Studies for the SuperB Factory

    SciTech Connect

    Boscolo, M.; Biagini, M.; Raimondi, P.; Sullivan, M.; Paoloni, E.; /INFN, Pisa

    2010-08-26

    The novel crab waist collision scheme under test at the DA{Phi}NE Frascati {Phi}-factory finds its natural application to the SuperB project, the asymmetric e{sup +}e{sup -} flavour factory at very high luminosity with relatively low beam currents and reduced backgrounds. The SuperB accelerator design requires a careful choice of beam parameters to reach a good trade-off between different effects. We present here simulation results for the Touschek backgrounds and lifetime obtained for both the low and high energy rings for different machine designs. A first set of horizontal collimators has been studied to stop Touschek particles. A study of the distributions of the Touschek particle losses at the interaction region into the detectors for further investigations is underway.

  4. Data scanner and event builder for the SMVD of the KEK B-factory

    SciTech Connect

    Tanaka, Manobu; Ikeda, Hirokazu; Ikeda, Mitsuo; Fujita, Youichi; Ozaki, Hitoshi . Physics Div.); Fukunaga, Chikara . Dept. of Physics)

    1994-02-01

    The authors are designing a readout system for a silicon microstrip vertex detector (SMVD) to be used in the KEK B-factory experiment. In order to obtain optimum numbers for the buffer size and the processing time they have constructed a simplified model using Verilog Hardware Description language (HDL). They estimated the live-time fractions of the SMVD readout system for various configurations.

  5. BPM Breakdown Potential in the PEP-II B-factory Storage Ring Collider

    SciTech Connect

    Weathersby, Stephen; Novokhatski, Alexander; /SLAC

    2010-02-10

    High current B-Factory BPM designs incorporate a button type electrode which introduces a small gap between the button and the beam chamber. For achievable currents and bunch lengths, simulations indicate that electric potentials can be induced in this gap which are comparable to the breakdown voltage. This study characterizes beam induced voltages in the existing PEP-II storage ring collider BPM as a function of bunch length and beam current.

  6. Neutrino factory and beta beam: accelerator options for future neutrino experiments

    SciTech Connect

    Zisman, Michael S.

    2012-06-03

    Two accelerator options for producing intense neutrino beams a Neutrino Factory based on stored muon beams and a Beta Beam facility based on stored beams of beta unstable ions are described. Technical challenges for each are described and current R&D efforts aimed at mitigating these challenges are indicated. Progress is being made in the design of both types of facility, each of which would extend the state-of-the-art in accelerator science.

  7. A factorial-design cluster randomised controlled trial investigating the cost-effectiveness of a nutrition supplement and an exercise programme on pneumonia incidence, walking capacity and body mass index in older people living in Santiago, Chile: the CENEX study protocol

    PubMed Central

    Dangour, Alan D; Albala, Cecilia; Aedo, Cristian; Elbourne, Diana; Grundy, Emily; Walker, Damian; Uauy, Ricardo

    2007-01-01

    Background Chile is currently undergoing a period of rapid demographic transition which has led to an increase in the proportion of older people in the population; the proportion aged 60 years and over, for example, increased from 8% of the population in 1980 to 12% in 2005. In an effort to promote healthy ageing and preserve function, the government of Chile has formulated a package of actions into the Programme of Complementary Feeding for the Older Population (PACAM) which has been providing a nutritional supplement to older people since 1998. PACAM distributes micronutrient fortified foods to individuals aged 70 years and over registered at Primary Health Centres and enrolled in the programme. The recommended serving size (50 g/day) of these supplements provides 50% of daily micronutrient requirements and 20% of daily energy requirements of older people. No information is currently available on the cost-effectiveness of the supplementation programme. Aim The aim of the CENEX cluster randomised controlled trial is to evaluate the cost-effectiveness of an ongoing nutrition supplementation programme, and a specially designed physical exercise intervention for older people of low to medium socio-economic status living in Santiago, Chile. Methods The study has been conceptualised as a public health programme effectiveness study and has been designed as a 24-month factorial cluster-randomised controlled trial conducted among 2800 individuals aged 65.0–67.9 years at baseline attending 28 health centres in Santiago. The main outcomes are incidence of pneumonia, walking capacity and change in body mass index over 24 months of intervention. Costing data (user and provider), collected at all levels, will enable the determination of the cost-effectiveness of the two interventions individually and in combination. The study is supported by the Ministry of Health in Chile, which is keen to expand and improve its national programme of nutrition for older people based on

  8. Beamlike photon pairs entangled by a 2x2 fiber

    SciTech Connect

    Lo, Hsin-Pin; Yabushita, Atsushi; Luo, Chih-Wei; Chen, Pochung; Kobayashi, Takayoshi

    2011-08-15

    Polarization-entangled photon pairs have been widely used as a light source of quantum communication. The polarization-entangled photon pairs are generally obtained at the crossing points of the light cones that are generated from a type-II nonlinear crystal. However, it is hard to pick up the photon pairs coming out from the crossing points because of their invisible wavelength and low intensity. In our previous work, we succeeded in generating polarization-entangled photon pairs by overlapping two light paths for the photon-pair generation. The photon pairs could be entangled in all of the generated photon pairs without clipping the crossing points, even with some difficulty in its alignment to overlap the two light paths. In this paper, we have developed an optical system which generates polarization-entangled photon pairs using a beamlike photon pair, without the difficulty in alignment. The measured results show that the photon pairs generated in the system are entangled in their polarizations.

  9. The Experience Factory: Strategy and Practice

    NASA Technical Reports Server (NTRS)

    Basili, Victor R.; Caldiera, Gianluigi

    1995-01-01

    The quality movement, that has had in recent years a dramatic impact on all industrial sectors, has recently reached the system and software industry. Although some concepts of quality management, originally developed for other product types, can be applied to software, its specificity as a product which is developed and not produced requires a special approach. This paper introduces a quality paradigm specifically tailored on the problem of the systems and software industry. Reuse of products, processes and experiences originating from the system life cycle is seen today as a feasible solution to the problem of developing higher quality systems at a lower cost. In fact, quality improvement is very often achieved by defining and developing an appropriate set of strategic capabilities and core competencies to support them. A strategic capability is, in this context, a corporate goal defined by the business position of the organization and implemented by key business processes. Strategic capabilities are supported by core competencies, which are aggregate technologies tailored to the specific needs of the organization in performing the needed business processes. Core competencies are non-transitional, have a consistent evolution, and are typically fueled by multiple technologies. Their selection and development requires commitment, investment and leadership. The paradigm introduced in this paper for developing core competencies is the Quality Improvement Paradigm which consists of six steps: (1) Characterize the environment, (2) Set the goals, (3) Choose the process, (4) Execute the process, (5) Analyze the process data, and (6) Package experience. The process must be supported by a goal oriented approach to measurement and control, and an organizational infrastructure, called Experience Factory. The Experience Factory is a logical and physical organization distinct from the project organizations it supports. Its goal is development and support of core competencies

  10. An Exploration into Framing Effects and Information Preferences: Implications for the Design of Energy Feedback Interfaces

    NASA Astrophysics Data System (ADS)

    Taylor-Brown, Peter

    A recent topic in the energy industry involves developing strategies to reduce the necessary peak production capacity of our future electricity infrastructure. One of these strategies is promoting behavioral change among individual energy consumers. An inherent problem with electricity consumption is that electricity is invisible, intangible, and abstract. Interfaces that provide people with useful feedback on their usage can help with understanding and reduction of consumption. These interfaces intend to empower individuals with ability to adopt less wasteful energy consumption behaviors. Skillful HCI design will include attention to informational preferences, and framing effects due to presentation choices. An online questionnaire was utilized to explore this domain, and the results identified design requirements for a home feedback interface. The final dataset contained responses from 36 male and 49 female United States residents. Cost () was perceived as the most useful metric and kW as the least useful. Respondent preference was expressed for lower levels of automation, which was not attributable to distrust of automation. Further, a test of framings effects showed a higher likelihood to change behavior to save 100 dollars per year than 2 per week (U=1248.5, p=0.001). A feedback interface design based on the questionnaire results was used in the second phase of the research. A 2x2x2 factorial design compared the effects of goal-type (specific vs. open-ended), metric-use ( vs. kWh), and visualization (graphical vs. text-only) on user experience, learning and behavior during a consumption reduction task. Results showed that goal-type affects the amount of diagnostic behavior conducted by participants (U=351.0, p=0.001). Goal-type and metric-use independently affect participant belief that they could reduce their consumption in their real home with the same feedback shown in the task, F(df=1,39)=24.77, p=0.001; F(df=1,39)=5.55, p=0.05. In addition, visualization

  11. VLBA Reveals Dust-Enshrouded "Supernova Factory"

    NASA Astrophysics Data System (ADS)

    2003-05-01

    Using the National Science Foundation's Very Long Baseline Array (VLBA) radio telescope, astronomers have discovered a newly-exploded star, or supernova, hidden deep in a dust-enshrouded "supernova factory" in a galaxy some 140 million light-years from Earth. "This supernova is likely to be part of a group of super star clusters that produce one such stellar explosion every two years," said James Ulvestad, of the National Radio Astronomy Observatory (NRAO) in Socorro, NM. "We're extremely excited by the tremendous insights into star formation and the early Universe that we may gain by observing this 'supernova factory,'" he added. Ulvestad worked with Susan Neff of NASA's Goddard Space Flight Center in Greenbelt, MD, and Stacy Teng, a graduate student at the University of Maryland, on the project. The scientists presented their findings to the American Astronomical Society's meeting in Nashville, TN. "These super star clusters likely are forming in much the same way that globular clusters formed in the early Universe, and thus provide us with a unique opportunity to learn about how some of the first stars formed billions of years ago," Neff said. The cluster is in an object called Arp 299, a pair of colliding galaxies, where regions of vigorous star formation have been found in past observations. Since 1990, four other supernova explosions have been seen optically in Arp 299. Observations with the NSF's Very Large Array (VLA) earlier showed a region near the nucleus of one of the colliding galaxies which had all the earmarks of prolific star formation. The astronomers focused on this region, prosaically dubbed "Source A," with the VLBA and the NSF's Robert C. Byrd Green Bank Telescope in 2002, and found four objects in this dusty cloud that are likely young supernova remnants. When they observed the region again in February 2003, there was a new, fifth, object located only 7 light-years from one of the previously detected objects. More observations on April 30-May

  12. Future Accelerators, Muon Colliders, and Neutrino Factories

    SciTech Connect

    Richard A Carrigan, Jr.

    2001-12-19

    Particle physics is driven by five great topics. Neutrino oscillations and masses are now at the fore. The standard model with extensions to supersymmetry and a Higgs to generate mass explains much of the field. The origins of CP violation are not understood. The possibility of extra dimensions has raised tantalizing new questions. A fifth topic lurking in the background is the possibility of something totally different. Many of the questions raised by these topics require powerful new accelerators. It is not an overstatement to say that for some of the issues, the accelerator is almost the experiment. Indeed some of the questions require machines beyond our present capability. As this volume attests, there are parts of the particle physics program that have been significantly advanced without the use of accelerators such as the subject of neutrino oscillations and many aspects of the particle-cosmology interface. At this stage in the development of physics, both approaches are needed and important. This chapter first reviews the status of the great accelerator facilities now in operation or coming on within the decade. Next, midrange possibilities are discussed including linear colliders with the adjunct possibility of gamma-gamma colliders, muon colliders, with precursor neutrino factories, and very large hadron colliders. Finally visionary possibilities are considered including plasma and laser accelerators.

  13. Lidar/DIAL detection of bomb factories

    NASA Astrophysics Data System (ADS)

    Fiorani, Luca; Puiu, Adriana; Rosa, Olga; Palucci, Antonio

    2013-10-01

    One of the aims of the project BONAS (BOmb factory detection by Networks of Advanced Sensors) is to develop a lidar/DIAL (differential absorption lidar) to detect precursors employed in the manufacturing of improvised explosive devices (IEDs). At first, a spectroscopic study has been carried out: the infrared (IR) gas phase spectrum of acetone, one of the more important IED precursors, has been procured from available databases and checked with cell measurements. Then, the feasibility of a lidar/DIAL for the detection of acetone vapors has been shown in laboratory, simulating the experimental conditions of a field campaign. Eventually, having in mind measurements in a real scenario, an interferent study has been performed, looking for all known compounds that share with acetone IR absorption in the spectral band selected for its detection. Possible interfering species were investigated, simulating both urban and industrial atmospheres and limits of acetone detection in both environments were identified. This study confirmed that a lidar/DIAL can detect low concentration of acetone at considerable distances.

  14. Factory daughters, the family, and nuptiality in Java.

    PubMed

    Wolf, D L

    1990-01-01

    The commercialization of agriculture, increasing landlessness, and an expanding labor class in rural areas of Java are all the result of industrialization. This work discusses the effect of female employment on marriage patterns of women working in rural factories. The central point is that employment has not only increased the financial autonomy of these women, but also increased the level of control they have over the choice of marriage partners. The data set used for analysis consisted of the observations of all factory workers and all non-factory females age 15-24 located in an agricultural village. The observations were make over a 15 month period between 1981-83. A follow up visit was made in 1986 and the following conclusions were then made: 1) the village study gave detailed data, but the data set was not large enough, thus a follow up study that encompasses more people is called for; 2) young rural female factory workers are more likely to chose their marriage partners than those engaged in traditional village labor. Of those that married and worked in factories, their fertility rate was significantly lower, compared to non-factory workers. Factory workers also had different family structures, because they spent less time living in extended families because of a larger income for the couple. This study indicates that increased economic control results in increased life decision control. This changed the daughter's economic relationship with her family and gives her more control in marriage decisions.

  15. Crabbed Waist Collisions in DAFNE and Super-B Design

    SciTech Connect

    Raimondi, P.; Alesini, D.; Biagini, M.E.; Biscari, C.; Boni, R.; Boscolo, M.; Bossi, F.; Buonomo, B.; Clozza, A.; Delle Monache, G.O.; Demma, T.; Di Pasquale, E.; Di Pirro, G.; Drago, A.; Gallo, A.; Ghigo, A.; Guiducci, S.; Ligi, C.; Marcellini, F.; Mazzitelli, Giovanni; Milardi, C.; /Frascati /Orsay, LAL /CERN /Rome III U. /Rome U. /Novosibirsk, IYF /KEK, Tsukuba /INFN, Pisa /INFN, Cosenza /SLAC /Frascati

    2011-11-02

    The new idea of increasing the luminosity of a collider with crab waist collisions and first experimental results from the DA{Phi}NE {Phi}-Factory at LNF, Frascati, using this concept are presented. Consequences for the design of future factories will be discussed. An outlook to the performance reach with crab waist collisions is given, with emphasis on future B Factories.

  16. Energy conservation through recycling of factory asphalt roofing waste

    SciTech Connect

    Shepherd, P.B.; Powers, T.J. . Manville Technical Center); Hardy, J.; Maloof, R.; Patenaude, C.; Zilfi, J. )

    1989-12-31

    Prior DOE laboratory research showed that it was possible to recover the energy resource represented in factory shingle waste. This waste could be processed and recycled into the asphalt composition used to make new shingles. This bench-scale research concluded that factory experiments were all that were needed to provide a basis for commercial implementation. The project reported here completed that full scale research. Factory fiber glass shingle waste was processed to a form suitable for recycling. The processed waste was then mixed into the asphalt used to make new shingles. Process parameters and shingle quality were measured to provide a basis for commercial implementation.

  17. Synthesis and X-ray structural characterization of a series of dimeric [Hg2(SePh)2X2(PR2R‧)2] compounds (R = tert-butyl; R‧ = 4-N,N-dimethylaniline and X = Cl, Br, I, SCN, SePh)

    NASA Astrophysics Data System (ADS)

    Stieler, Rafael; Faoro, Eliandro; Cechin, Camila Nunes; Floriano, Luana; Lang, Ernesto Schulz

    2015-01-01

    This article presents the syntheses and characterization of five new compounds with the general formula [Hg2(SePh)2X2(PR2R‧)2] (R = tert-butyl; R‧ = 4-N,N-dimethylaniline), where X = Cl (1a), Br (1b), I (1c), SCN (2), SePh (3). The compounds crystallized as dimeric {HgSe} units, although most of these chalcogenolate compounds appeared to be polymeric adamantanoid or fused adamantanoid species. The ligand structures of these compounds limited the growth of the molecular structures and promoted the formation of the dimeric form alone. The mercury centers were connected to one another through one μ-Cl and one μ-SePh bridge in 1a, and through two μ-SePh bridges in 1b, 1c, 2, and 3. The compounds were characterized by single crystal X-ray diffractometry, TGA, elemental analysis, and infrared spectroscopy.

  18. Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong)

    PubMed Central

    Park, Jin-Sun; Shin, Joon-Han; Hong, Taek-Jong; Seo, Hong-Seog; Shim, Wan-Joo; Baek, Sang-Hong; Jeong, Jin-Ok; Ahn, Youngkeun; Kang, Woong-Chol; Kim, Young-Hak; Kim, Sang-Hyun; Hyon, Min-Su; Choi, Dong-Hoon; Nam, Chang-Wook; Park, Tae-Ho; Lee, Sang-Chol; Kim, Hyo-Soo

    2016-01-01

    The pill burden of patients with hypertension and dyslipidemia can result in poor medication compliance. This study aimed to evaluate the efficacy and safety of fixed-dose combination (FDC) therapy with olmesartan medoxomil (40 mg) and rosuvastatin (20 mg) in Korean patients with mild to moderate hypertension and dyslipidemia. This multicenter, randomized, double-blind, factorial-design study included patients aged ≥20 years with mild to moderate essential hypertension and dyslipidemia. Patients were randomly assigned to receive FDC therapy (40 mg olmesartan medoxomil, 20 mg rosuvastatin), 40 mg olmesartan medoxomil, 20 mg rosuvastatin, or a placebo. The percentage change from baseline in low-density lipoprotein cholesterol levels was compared between FDC therapy and olmesartan medoxomil, and the change from baseline in diastolic blood pressure was compared between FDC therapy and rosuvastatin 8 weeks after treatment. A total of 162 patients were included. The least square mean percentage change (standard error) from baseline in low-density lipoprotein cholesterol levels 8 weeks after treatment was significantly greater in the FDC than in the olmesartan medoxomil group (−52.3% [2.8%] vs −0.6% [3.5%], P<0.0001), and the difference was −51.7% (4.1%) (95% confidence interval: −59.8% to −43.6%). The least square mean change (standard error) from baseline in diastolic blood pressure 8 weeks after treatment was significantly greater in the FDC group than in the rosuvastatin group (−10.4 [1.2] mmHg vs 0.1 [1.6] mmHg, P<0.0001), and the difference was −10.5 (1.8) mmHg (95% confidence interval: −14.1 to −6.9 mmHg). There were 50 adverse events in 41 patients (22.7%) and eight adverse drug reactions in five patients (2.8%). The study found that FDC therapy with olmesartan medoxomil and rosuvastatin is an effective, safe treatment for patients with hypertension and dyslipidemia. This combination may improve medication compliance in patients with a large

  19. Efficacy and safety of fixed-dose combination therapy with olmesartan medoxomil and rosuvastatin in Korean patients with mild to moderate hypertension and dyslipidemia: an 8-week, multicenter, randomized, double-blind, factorial-design study (OLSTA-D RCT: OLmesartan rosuvaSTAtin from Daewoong).

    PubMed

    Park, Jin-Sun; Shin, Joon-Han; Hong, Taek-Jong; Seo, Hong-Seog; Shim, Wan-Joo; Baek, Sang-Hong; Jeong, Jin-Ok; Ahn, Youngkeun; Kang, Woong-Chol; Kim, Young-Hak; Kim, Sang-Hyun; Hyon, Min-Su; Choi, Dong-Hoon; Nam, Chang-Wook; Park, Tae-Ho; Lee, Sang-Chol; Kim, Hyo-Soo

    2016-01-01

    The pill burden of patients with hypertension and dyslipidemia can result in poor medication compliance. This study aimed to evaluate the efficacy and safety of fixed-dose combination (FDC) therapy with olmesartan medoxomil (40 mg) and rosuvastatin (20 mg) in Korean patients with mild to moderate hypertension and dyslipidemia. This multicenter, randomized, double-blind, factorial-design study included patients aged ≥20 years with mild to moderate essential hypertension and dyslipidemia. Patients were randomly assigned to receive FDC therapy (40 mg olmesartan medoxomil, 20 mg rosuvastatin), 40 mg olmesartan medoxomil, 20 mg rosuvastatin, or a placebo. The percentage change from baseline in low-density lipoprotein cholesterol levels was compared between FDC therapy and olmesartan medoxomil, and the change from baseline in diastolic blood pressure was compared between FDC therapy and rosuvastatin 8 weeks after treatment. A total of 162 patients were included. The least square mean percentage change (standard error) from baseline in low-density lipoprotein cholesterol levels 8 weeks after treatment was significantly greater in the FDC than in the olmesartan medoxomil group (-52.3% [2.8%] vs -0.6% [3.5%], P<0.0001), and the difference was -51.7% (4.1%) (95% confidence interval: -59.8% to -43.6%). The least square mean change (standard error) from baseline in diastolic blood pressure 8 weeks after treatment was significantly greater in the FDC group than in the rosuvastatin group (-10.4 [1.2] mmHg vs 0.1 [1.6] mmHg, P<0.0001), and the difference was -10.5 (1.8) mmHg (95% confidence interval: -14.1 to -6.9 mmHg). There were 50 adverse events in 41 patients (22.7%) and eight adverse drug reactions in five patients (2.8%). The study found that FDC therapy with olmesartan medoxomil and rosuvastatin is an effective, safe treatment for patients with hypertension and dyslipidemia. This combination may improve medication compliance in patients with a large pill burden. PMID

  20. The Factorial Validity of The Maslach Burnout Inventory--General Survey in Representative Samples of Eight Different Occupational Groups

    ERIC Educational Resources Information Center

    Langballe, Ellen Melbye; Falkum, Erik; Innstrand, Siw Tone; Aasland, Olaf Gjerlow

    2006-01-01

    The Maslach Burnout Inventory--General Survey (MBI-GS) is designed to measure the three subdimensions (exhaustion, cynicism, and professional efficacy) of burnout in a wide range of occupations. This article examines the factorial validity of the MBI-GS across eight different occupational groups in Norway: lawyers, physicians, nurses, teachers,…

  1. The Experiment Factory: Standardizing Behavioral Experiments.

    PubMed

    Sochat, Vanessa V; Eisenberg, Ian W; Enkavi, A Zeynep; Li, Jamie; Bissett, Patrick G; Poldrack, Russell A

    2016-01-01

    The administration of behavioral and experimental paradigms for psychology research is hindered by lack of a coordinated effort to develop and deploy standardized paradigms. While several frameworks (Mason and Suri, 2011; McDonnell et al., 2012; de Leeuw, 2015; Lange et al., 2015) have provided infrastructure and methods for individual research groups to develop paradigms, missing is a coordinated effort to develop paradigms linked with a system to easily deploy them. This disorganization leads to redundancy in development, divergent implementations of conceptually identical tasks, disorganized and error-prone code lacking documentation, and difficulty in replication. The ongoing reproducibility crisis in psychology and neuroscience research (Baker, 2015; Open Science Collaboration, 2015) highlights the urgency of this challenge: reproducible research in behavioral psychology is conditional on deployment of equivalent experiments. A large, accessible repository of experiments for researchers to develop collaboratively is most efficiently accomplished through an open source framework. Here we present the Experiment Factory, an open source framework for the development and deployment of web-based experiments. The modular infrastructure includes experiments, virtual machines for local or cloud deployment, and an application to drive these components and provide developers with functions and tools for further extension. We release this infrastructure with a deployment (http://www.expfactory.org) that researchers are currently using to run a set of over 80 standardized web-based experiments on Amazon Mechanical Turk. By providing open source tools for both deployment and development, this novel infrastructure holds promise to bring reproducibility to the administration of experiments, and accelerate scientific progress by providing a shared community resource of psychological paradigms.

  2. The Experiment Factory: Standardizing Behavioral Experiments

    PubMed Central

    Sochat, Vanessa V.; Eisenberg, Ian W.; Enkavi, A. Zeynep; Li, Jamie; Bissett, Patrick G.; Poldrack, Russell A.

    2016-01-01

    The administration of behavioral and experimental paradigms for psychology research is hindered by lack of a coordinated effort to develop and deploy standardized paradigms. While several frameworks (Mason and Suri, 2011; McDonnell et al., 2012; de Leeuw, 2015; Lange et al., 2015) have provided infrastructure and methods for individual research groups to develop paradigms, missing is a coordinated effort to develop paradigms linked with a system to easily deploy them. This disorganization leads to redundancy in development, divergent implementations of conceptually identical tasks, disorganized and error-prone code lacking documentation, and difficulty in replication. The ongoing reproducibility crisis in psychology and neuroscience research (Baker, 2015; Open Science Collaboration, 2015) highlights the urgency of this challenge: reproducible research in behavioral psychology is conditional on deployment of equivalent experiments. A large, accessible repository of experiments for researchers to develop collaboratively is most efficiently accomplished through an open source framework. Here we present the Experiment Factory, an open source framework for the development and deployment of web-based experiments. The modular infrastructure includes experiments, virtual machines for local or cloud deployment, and an application to drive these components and provide developers with functions and tools for further extension. We release this infrastructure with a deployment (http://www.expfactory.org) that researchers are currently using to run a set of over 80 standardized web-based experiments on Amazon Mechanical Turk. By providing open source tools for both deployment and development, this novel infrastructure holds promise to bring reproducibility to the administration of experiments, and accelerate scientific progress by providing a shared community resource of psychological paradigms. PMID:27199843

  3. The Experiment Factory: Standardizing Behavioral Experiments.

    PubMed

    Sochat, Vanessa V; Eisenberg, Ian W; Enkavi, A Zeynep; Li, Jamie; Bissett, Patrick G; Poldrack, Russell A

    2016-01-01

    The administration of behavioral and experimental paradigms for psychology research is hindered by lack of a coordinated effort to develop and deploy standardized paradigms. While several frameworks (Mason and Suri, 2011; McDonnell et al., 2012; de Leeuw, 2015; Lange et al., 2015) have provided infrastructure and methods for individual research groups to develop paradigms, missing is a coordinated effort to develop paradigms linked with a system to easily deploy them. This disorganization leads to redundancy in development, divergent implementations of conceptually identical tasks, disorganized and error-prone code lacking documentation, and difficulty in replication. The ongoing reproducibility crisis in psychology and neuroscience research (Baker, 2015; Open Science Collaboration, 2015) highlights the urgency of this challenge: reproducible research in behavioral psychology is conditional on deployment of equivalent experiments. A large, accessible repository of experiments for researchers to develop collaboratively is most efficiently accomplished through an open source framework. Here we present the Experiment Factory, an open source framework for the development and deployment of web-based experiments. The modular infrastructure includes experiments, virtual machines for local or cloud deployment, and an application to drive these components and provide developers with functions and tools for further extension. We release this infrastructure with a deployment (http://www.expfactory.org) that researchers are currently using to run a set of over 80 standardized web-based experiments on Amazon Mechanical Turk. By providing open source tools for both deployment and development, this novel infrastructure holds promise to bring reproducibility to the administration of experiments, and accelerate scientific progress by providing a shared community resource of psychological paradigms. PMID:27199843

  4. Make your company a talent factory.

    PubMed

    Ready, Douglas A; Conger, Jay A

    2007-06-01

    Despite the great sums of money companies dedicate to talent management systems, many still struggle to fill key positions - limiting their potential for growth in the process. Virtually all the human resource executives in the authors' 2005 survey of 40 companies around the world said that their pipeline of high-potential employees was insufficient to fill strategic management roles. The survey revealed two primary reasons for this. First, the formal procedures for identifying and developing next-generation leaders have fallen out of sync with what companies need to grow or expand into new markets. To save money, for example, some firms have eliminated positions that would expose high-potential employees to a broad range of problems, thus sacrificing future development opportunities that would far outweigh any initial savings from the job cuts. Second, HR executives often have trouble keeping top leaders' attention on talent issues, despite those leaders' vigorous assertions that obtaining and keeping the best people is a major priority. If passion for that objective doesn't start at the top and infuse the culture, say the authors, talent management can easily deteriorate into the management of bureaucratic routines. Yet there are companies that can face the future with confidence. These firms don't just manage talent, they build talent factories. The authors describe the experiences of two such corporations - consumer products icon Procter & Gamble and financial services giant HSBC Group -that figured out how to develop and retain key employees and fill positions quickly to meet evolving business needs. Though each company approached talent management from a different direction, they both maintained a twin focus on functionality (rigorous talent processes that support strategic and cultural objectives) and vitality (management's emotional commitment, which is reflected in daily actions).

  5. Make your company a talent factory.

    PubMed

    Ready, Douglas A; Conger, Jay A

    2007-06-01

    Despite the great sums of money companies dedicate to talent management systems, many still struggle to fill key positions - limiting their potential for growth in the process. Virtually all the human resource executives in the authors' 2005 survey of 40 companies around the world said that their pipeline of high-potential employees was insufficient to fill strategic management roles. The survey revealed two primary reasons for this. First, the formal procedures for identifying and developing next-generation leaders have fallen out of sync with what companies need to grow or expand into new markets. To save money, for example, some firms have eliminated positions that would expose high-potential employees to a broad range of problems, thus sacrificing future development opportunities that would far outweigh any initial savings from the job cuts. Second, HR executives often have trouble keeping top leaders' attention on talent issues, despite those leaders' vigorous assertions that obtaining and keeping the best people is a major priority. If passion for that objective doesn't start at the top and infuse the culture, say the authors, talent management can easily deteriorate into the management of bureaucratic routines. Yet there are companies that can face the future with confidence. These firms don't just manage talent, they build talent factories. The authors describe the experiences of two such corporations - consumer products icon Procter & Gamble and financial services giant HSBC Group -that figured out how to develop and retain key employees and fill positions quickly to meet evolving business needs. Though each company approached talent management from a different direction, they both maintained a twin focus on functionality (rigorous talent processes that support strategic and cultural objectives) and vitality (management's emotional commitment, which is reflected in daily actions). PMID:17580649

  6. Combustion of liquid paint wastes in fluidized bed boiler as element of waste management system in the paint factory

    SciTech Connect

    Soko, W.A.; Biaecka, B.

    1998-12-31

    In this paper the solution to waste problems in the paint industry is presented by describing their combustion in a fluidized bed boiler as a part of the waste management system in the paint factory. Based on the Cleaner Production idea and concept of integration of design process with a future exploitation of equipment, some modifications of the waste management scheme in the factory are discussed to reduce the quantity of toxic wastes. To verify this concept combustion tests of paint production wastes and cocombustion of paint wastes with coal in an adopted industrial boiler were done. Results of these tests are presented in the paper.

  7. Down sampled signal processing for a B Factory bunch-by-bunch feedback system

    SciTech Connect

    Hindi, H.; Hosseini, W.; Briggs, D.; Fox, J.; Hutton, A.

    1992-03-01

    A bunch-by-bunch feedback scheme is studied for damping coupled bunch synchrotron oscillations in the proposed PEP II B Factory. The quasi-linear feedback systems design incorporates a phase detector to provide a quantized measure of bunch phase, digital signal processing to compute an error correction signal and a kicker system to correct the energy of the bunches. A farm of digital processors, operating in parallel, is proposed to compute correction signals for the 1658 bunches of the B Factory. This paper studies the use of down sampled processing to reduce the computational complexity of the feedback system. We present simulation results showing the effect of down sampling on beam dynamics. Results show that down sampled processing can reduce the scale of the processing task by a factor of 10.

  8. Exploring the Optical Transient Sky with the Palomar Transient Factory

    NASA Astrophysics Data System (ADS)

    Rau, Arne; Kulkarni, Shrinivas R.; Law, Nicholas M.; Bloom, Joshua S.; Ciardi, David; Djorgovski, George S.; Fox, Derek B.; Gal-Yam, Avishay; Grillmair, Carl C.; Kasliwal, Mansi M.; Nugent, Peter E.; Ofek, Eran O.; Quimby, Robert M.; Reach, William T.; Shara, Michael; Bildsten, Lars; Cenko, S. Bradley; Drake, Andrew J.; Filippenko, Alexei V.; Helfand, David J.; Helou, George; Howell, D. Andrew; Poznanski, Dovi; Sullivan, Mark

    2009-12-01

    The Palomar Transient Factory (PTF) is a wide-field experiment designed to investigate the optical transient and variable sky on time scales from minutes to years. PTF uses the CFH12k mosaic camera, with a field of view of 7.9 deg2 and a plate scale of 1'' pixel-1, mounted on the Palomar Observatory 48 inch Samuel Oschin Telescope. The PTF operation strategy is devised to probe the existing gaps in the transient phase space and to search for theoretically predicted, but not yet detected, phenomena, such as fallback supernovae, macronovae, .Ia supernovae, and the orphan afterglows of gamma-ray bursts. PTF will also discover many new members of known source classes, from cataclysmic variables in their various avatars to supernovae and active galactic nuclei, and will provide important insights into understanding galactic dynamics (through RR Lyrae stars) and the solar system (asteroids and near-Earth objects). The lessons that can be learned from PTF will be essential for the preparation of future large synoptic sky surveys like the Large Synoptic Survey Telescope. In this article we present the scientific motivation for PTF and describe in detail the goals and expectations for this experiment.

  9. Supernova Discoveries from the Nearby Supernova Factory (SNfactory)

    DOE Data Explorer

    SNfactory International Collaboration,

    The Nearby Supernova Factory is an experiment designed to collect data on more Type Ia supernovae than have ever been studied in a single project before, and in so doing, to answer some fundamental questions about the nature of the universe. Type Ia supernovae are extraordinarily bright, remarkably uniform objects which make excellent "standard candles" for measuring the expansion rate of the universe. However, such stellar explosions are very rare, occurring only a couple of times per millenium in a typical galaxy, and remaining bright enough to detect only for a few weeks. Previous studies of Type Ia supernovae led to the discovery of the mysterious "dark energy" that is causing the universe to expand at an accelerating rate. To reduce the statistical uncertainties in previous experimental data, extensive spectral and photometric monitoring of more Type Ia supernovae is required. The SNfactory collaboration has built an automated system consisting of specialized software and custom-built hardware that systematically searches the sky for new supernovae, screens potential candidates, then performs multiple spectral and photometric observations on each supernova. These observations are stored in a database to be made available to supernova researchers world-wide for further study and analysis [copied from http://snfactory.lbl.gov/snf/snf-about.html]. Users must register and agree to the open access honor system. Finding charts are in FITS format and may not be accessible through normal browser settings.

  10. Factorial kriging analysis applied to geological data from petroleum exploration

    SciTech Connect

    Jaquet, O.

    1989-10-01

    A regionalized variable, thickness of the reservoir layer, from a gas field is decomposed by factorial kriging analysis. Maps of the obtained components may be associated with depositional environments that are favorable for petroleum exploration.

  11. Three-dimensional structure of Rubella virus factories

    SciTech Connect

    Fontana, Juan; Lopez-Iglesias, Carmen; Tzeng, Wen-Ping; Frey, Teryl K.; Fernandez, Jose J.; Risco, Cristina

    2010-09-30

    Viral factories are complex structures in the infected cell where viruses compartmentalize their life cycle. Rubella virus (RUBV) assembles factories by recruitment of rough endoplasmic reticulum (RER), mitochondria and Golgi around modified lysosomes known as cytopathic vacuoles or CPVs. These organelles contain active replication complexes that transfer replicated RNA to assembly sites in Golgi membranes. We have studied the structure of RUBV factory in three dimensions by electron tomography and freeze-fracture. CPVs contain stacked membranes, rigid sheets, small vesicles and large vacuoles. These membranes are interconnected and in communication with the endocytic pathway since they incorporate endocytosed BSA-gold. RER and CPVs are coupled through protein bridges and closely apposed membranes. Golgi vesicles attach to the CPVs but no tight contacts with mitochondria were detected. Immunogold labelling confirmed that the mitochondrial protein p32 is an abundant component around and inside CPVs where it could play important roles in factory activities.

  12. 2. EAST ELEVATION OF IPA FACTORY; TWOSTORY SECTION BUILT IN ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. EAST ELEVATION OF IPA FACTORY; TWO-STORY SECTION BUILT IN 1892 AND PARTIALLY DESTROYED PARAPET SECTION BUILT CA. 1948. BRICK CHIMNEY ALSO BUILT CA. 1948. - Illinois Pure Aluminum Company, 109 Holmes Street, Lemont, Cook County, IL

  13. Reliability and Factorial Validity of the Student Development Inventory.

    ERIC Educational Resources Information Center

    Jackson, Lorraine Morlock; And Others

    1985-01-01

    The Student Development Inventory and its seven subscales were administered to 163 college students to determine its reliability and factorial validity. Results suggested that it is a reliable and convenient attitudinal inventory. (Sample items are included.) (Author/GDC)

  14. Pion production for neutrino factories and muon colliders

    SciTech Connect

    Mokhov, N.V.; Guidman, K.K.; Strait, J.B.; Striganov, S.I.; /Fermilab

    2009-12-01

    Optimization of pion and muon production/collection for neutrino factories and muon colliders is described along with recent developments of the MARS15 code event generators and effects influencing the choice of the optimal beam energy.

  15. RIKEN Radio Isotope Beam Factory: Japanese Flagship for Nuclear Science

    NASA Astrophysics Data System (ADS)

    En'yo, Hideto

    2015-11-01

    Recent activities at the RIKEN Radio Isotope Beam Factory (RIBF) are reported together with its history and future prospects. RIBF is the Japanese flagship for nuclear science, and at this moment is the world flagship machine.

  16. 19. 1925 Main Factory building, interior, view of second floor's ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. 1925 Main Factory building, interior, view of second floor's permutit room, view looking east showing water treatment tanks - North Star Woolen Mill, 109 Portland Avenue South, Minneapolis, Hennepin County, MN

  17. 1. VIEW LOOKING SOUTHWEST AT PARTIAL EAST ELEVATION OF FACTORY, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW LOOKING SOUTHWEST AT PARTIAL EAST ELEVATION OF FACTORY, SHOWING FORMER OHIO & ERIE CANAL PRISM IN FOREGROUND THAT WAS USED AS WATER RESERVOIR (500,000 GALLON) - Jaite Paper Mill, 1200 West Highland Road, Sagamore Hills, Summit County, OH

  18. Application of fiber laser for a Higgs factory

    SciTech Connect

    Chou, W.

    2014-06-04

    This paper proposes a medium size(~6km) circular Higgs factory based on a photon collider. The recent breakthrough in fiber laser technology by means of a coherent amplifier network makes such a collider feasible and probably also affordable.

  19. Yo Puedo Leer: Un Programa Personalizado de Lectura en un Aula Primaria: Reporte de un Modelo Comprobado (I Can Read: A Personalized Reading Program in a Primary Classroom: A Report on a Verified Model).

    ERIC Educational Resources Information Center

    Mendenhall, Susie B.; Sledjeski, Stephen

    This monograph discusses an investigation carried out in a school which has implemented an experimental reading program. Achievement, self-esteem, and social acceptance gains and their interrelations were investigated. Treatment groups (experimental and control) were the three independent variables providing a 2 x 2 x 2 factorial design. Data were…

  20. The Correlation between Visual-Haptic Perceptual Style and Student Ability To Solve Orthographic Projection Problems in a Beginning College Drafting Course Incorporating Computer Aided Drafting.

    ERIC Educational Resources Information Center

    Baird, David A.

    A study determined the effectiveness of computer-aided drafting (CAD) and standard drafting instruction on the ability of students with differing visual-haptic perceptual styles to solve orthographic projection problems. A 2x2x2 factorial design was chosen to compare two levels of perceptual style with two levels of treatment and two levels of…

  1. Race and Sex Differences Among Children in Perception of Emotion. Boston University Communication Research Center Report No. 27.

    ERIC Educational Resources Information Center

    Gitter, A. George; Quincy, Arthur J., Jr.

    A 2x2x2 factorial design was utilized to investigate the effects of race of expressor (black and white), race of perceiver, and sex of perceiver on perception of emotion (POE) in children. Perception of four emotions (anger, happiness, surprise, and pain) was analyzed in terms of three scores as DV's: (1) overall accuracy scores, (2) correct…

  2. Self Management Techniques and Disclosure of Sero Status

    ERIC Educational Resources Information Center

    Falaye, Ajibola; Afolayan, Joel Adeleke

    2015-01-01

    This study looked at using Self Management Technique (SMT) to promote self-disclosure of Sero status in Kwara State, Nigeria. A pre-test, post-test and control group quasi experimental design using a 2x2x2 factorial matrix was adopted. Sixty participants were sampled by balloting from two HIV/AIDS screening centres. Four instruments were used such…

  3. Multiple-Component Remediation for Developmental Reading Disabilities: IQ, Socioeconomic Status, and Race as Factors in Remedial Outcome

    ERIC Educational Resources Information Center

    Morris, Robin D.; Lovett, Maureen W.; Wolf, Maryanne; Sevcik, Rose A.; Steinbach, Karen A.; Frijters, Jan C.; Shapiro, Marla B.

    2012-01-01

    Results from a controlled evaluation of remedial reading interventions are reported: 279 young disabled readers were randomly assigned to a program according to a 2 x 2 x 2 factorial design (IQ, socioeconomic status [SES], and race). The effectiveness of two multiple-component intervention programs for children with reading disabilities (PHAB +…

  4. The Advance Organizer Concept: Some Methodological Questions.

    ERIC Educational Resources Information Center

    Salmon, Robert; And Others

    The effect of an advance organizer on post test performance was studied in a 2 X 2 X 2 factorial design with the effects of the organizer, pretest and mathematics learning passage controlled. An advance organizer of approximately 500 words and a learning passage of approximately 1,000 words were developed. A 41-item multiple choice test based on…

  5. 12. SOUTH INSIDE FACTORY ALONG EAST WALL TO PARTS STORAGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. SOUTH INSIDE FACTORY ALONG EAST WALL TO PARTS STORAGE SHELVES AND BINS OUTSIDE PARTITION WALL OF OFFICE. THE SOUTH PARTITION WALL IN THIS AREA IS FITTED WITH SHELVES COVERED WITH BOXES CONTAINING MANUSCRIPT COMPANY RECORDS. THE BENCH IN THE RIGHT FOREGROUND WAS USED FOR ATTACHING WROUGHT IRON CONNECTIONS TO THE ENDS OF WOODEN SUCKER RODS; THE WOODEN RODS WERE STORED ON THE RACKS ALONG THE EAST WALL OF THIS AREA. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  6. Expert Meeting Report: Advanced Envelope Research for Factory Built Housing

    SciTech Connect

    Levy, E.; Mullens, M.; Tompos, E.; Kessler, B.; Rath, P.

    2012-04-01

    This report provides information about the Building America expert meeting on advanced envelope research for factory built housing, hosted by the ARIES Collaborative on October 11, 2011, in Phoenix, Arizona. The goals of this meeting were to provide a comprehensive solution to the use of three previously selected advanced alternatives for factory-built wall construction, assess each option focusing on major issues relating to viability and commercial potential, and determine additional steps are required to reach this potential.

  7. Expert Meeting Report: Advanced Envelope Research for Factory Built Housing

    SciTech Connect

    Levy, E.; Mullens, M.; Tompos, E.; Kessler, B.; Rath, P.

    2012-04-01

    This report provides information about the expert meeting on advanced envelope research for factory built housing, hosted by the ARIES Collaborative on October 11, 2011, in Phoenix, Arizona. The goals of this meeting were to provide a comprehensive solution to the use of three previously selected advanced alternatives for factory-built wall construction, assess each option focusing on major issues relating to viability and commercial potential, and determine additional steps are required to reach this potential.

  8. 9. NORTHEAST FROM SOUTH ENTRANCE ACROSS RECEIVING AREA OF FACTORY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. NORTHEAST FROM SOUTH ENTRANCE ACROSS RECEIVING AREA OF FACTORY PAST THE GLASS-ENCLOSED OFFICE TOWARD SHOP AREA. BESIDE THE VERTICAL POST ROOF SUPPORT IN THE LEFT FOREGROUND IS A SCALE AND DRAFTING TABLE. BESIDE THE OFFICE WALL ON THE RIGHT IS A SMALL SHOP REPAIR BENCH, WHILE ABOVE THE OFFICE WINDOWS ARE BOXES OF COMPANY MANUSCRIPT BUSINESS RECORDS. THE WELDED METAL PIPE RACK IS A MODERN INTRUSION. - Kregel Windmill Company Factory, 1416 Central Avenue, Nebraska City, Otoe County, NE

  9. The role of specialized transcription factories in chromosome pairing.

    PubMed

    Xu, Meng; Cook, Peter R

    2008-11-01

    Homologous chromosomes can pair in somatic and germ line cells, and many mechanisms have been proposed to explain how they do so. One popular class of models involves base-pairing between DNA strands catalyzed by recombination proteins, but pairing still occurs in mutants lacking the relevant functional proteins. We discuss an alternative based on two observations: transcription occurs in factories that specialize in transcribing specific gene sub-sets, and chromosomes only pair when transcribed. Each chromosome in the haploid set has a unique array of transcription units strung along its length; we suggest each is organized into clouds of loops tethered to specialized factories. Only homologs share similar strings of clouds and factories. Pairing begins when a promoter on one chromosome initiates in the homologous and specialized factory organized mainly by its homologous partner. This transiently ties the two homologs together, to increase the chances that adjacent promoters initiate in their homologous factories and that the two homologs will be zipped together. Then, interactions between promoters and RNA polymerases in the factories mediate pairing.

  10. Tracking parameter simulation for the Turkish accelerator center particle factory tracker system

    NASA Astrophysics Data System (ADS)

    Tapan, I.; Pilicer, E.; Pilicer, F. B.

    2016-09-01

    The silicon tracker part of the Turkish Accelerator Center super charm particle factory detector was designed for effectively tracking charged particles with momentum values up to 2.0 GeV/c. In this work, the FLUKA simulation code has been used to estimate the track parameters and their resolutions in the designed tracker system. These results have been compared with those obtained by the tkLayout software package. The simulated track parameter resolutions are compatible with the physics goals of the tracking detector.

  11. Microbial Consortia Engineering for Cellular Factories: in vitro to in silico systems

    PubMed Central

    Bernstein, Hans C; Carlson, Ross P

    2012-01-01

    This mini-review discusses the current state of experimental and computational microbial consortia engineering with a focus on cellular factories. A discussion of promising ecological theories central to community resource usage is presented to facilitate interpretation of consortial designs. Recent case studies exemplifying different resource usage motifs and consortial assembly templates are presented. The review also highlights in silico approaches to design and to analyze consortia with an emphasis on stoichiometric modeling methods. The discipline of microbial consortia engineering possesses a widely accepted potential to generate highly novel and effective bio-catalysts for applications from biofuels to specialty chemicals to enhanced mineral recovery. PMID:24688677

  12. Radiation safety interlock system for Photon Factory X-ray beam lines

    NASA Astrophysics Data System (ADS)

    Satow, Yoshinori; Kosuge, Takashi; Matsushita, Tadashi

    1988-02-01

    Self-contained interlock systems for the X-ray beam lines of the Photon Factory were designed and fabricated in order to protect experimenters and the service staff from radiation hazards while at the same time providing experimenters with smooth and easy access to the synchrotron radiation sources. The interlock systems utilize programmable sequence controllers in order to meet the individual safety logic required for beam line characteristics. The environment as well as components related to the interlock systems, system features, safety logic and operating conditions are described along with the design principles. A few operational remarks concerning the interlock systems are also presented.

  13. SuperB: A High-Luminosity Asymmetric e+e- Super Flavor Factory

    SciTech Connect

    Bona, M.; /et al.

    2007-05-18

    We discuss herein the exciting physics program that can be accomplished with a very large sample of heavy quark and heavy lepton decays produced in the very clean environment of an e{sup +}e{sup -} collider; a program complementary to that of an experiment such as LHCb at a hadronic machine. It then presents the conceptual design of a new type of e{sup +}e{sup -} collider that produces a nearly two-order-of-magnitude increase in luminosity over the current generation of asymmetric B Factories. The key idea is the use of low emittance beams produced in an accelerator lattice derived from the ILC Damping Ring Design, together with a new collision region, again with roots in the ILC final focus design, but with important new concepts developed in this design effort. Remarkably, SuperB produces this very large improvement in luminosity with circulating currents and wallplug power similar to those of the current B Factories. There is clear synergy with ILC R&D; design efforts have already influenced one another, and many aspects of the ILC Damping Rings and Final Focus would be operationally tested at SuperB. Finally, the design of an appropriate detector, based on an upgrade of BABAR as an example, is discussed in some detail. A preliminary cost estimate is presented, as is an example construction timeline.

  14. Black hole as a wormhole factory

    NASA Astrophysics Data System (ADS)

    Kim, Sung-Won; Park, Mu-In

    2015-12-01

    There have been lots of debates about the final fate of an evaporating black hole and the singularity hidden by an event horizon in quantum gravity. However, on general grounds, one may argue that a black hole stops radiation at the Planck mass (ħc / G) 1 / 2 ∼10-5 g, where the radiated energy is comparable to the black hole's mass. And also, it has been argued that there would be a wormhole-like structure, known as "spacetime foam", due to large fluctuations below the Planck length (ħG /c3) 1 / 2 ∼10-33 cm. In this paper, as an explicit example, we consider an exact classical solution which represents nicely those two properties in a recently proposed quantum gravity model based on different scaling dimensions between space and time coordinates. The solution, called "Black Wormhole", consists of two different states, depending on its mass parameter M and an IR parameter ω: For the black hole state (with ωM2 > 1 / 2), a non-traversable wormhole occupies the interior region of the black hole around the singularity at the origin, whereas for the wormhole state (with ωM2 < 1 / 2), the interior wormhole is exposed to an outside observer as the black hole horizon is disappearing from evaporation. The black hole state becomes thermodynamically stable as it approaches the merging point where the interior wormhole throat and the black hole horizon merges, and the Hawking temperature vanishes at the exact merge point (with ωM2 = 1 / 2). This solution suggests the "Generalized Cosmic Censorship" by the existence of a wormhole-like structure which protects the naked singularity even after the black hole evaporation. One could understand the would-be wormhole inside the black hole horizon as the result of microscopic wormholes created by "negative" energy quanta which have entered the black hole horizon in Hawking radiation process; the quantum black hole could be a wormhole factory! It is found that this speculative picture may be consistent with the recent " ER

  15. The Subduction Factory of Hydrocarbon Formation

    NASA Astrophysics Data System (ADS)

    Kleschev, K. A.

    2003-04-01

    THE SUBDUCTION FACTORY OF HYDROCARBON FORMATION K. A. Kleschev VNIGNI, Moscow, Russia balanyuk@sio.rssi.ru In the zones of collision of continental lithospheric plates, the subducting plates drive down great amounts of sediments formed at the former passive margins. This sedimentary layer, enclosed between two plates, contains significant quantities of hydrocarbons and occurs under the effect of strong shear deformations and special thermodynamic conditions. As the mass of the sediments passing through this zone is rather great, there are favorable conditions for occurrence of numerous hydrocarbon fields of industrial importance, including fields giants. Combined consideration of geodynamic and fluidodynamic aspects in a model of lithospheric plates collision enables to understand the influence of P T conditions and shear deformations on the mechanism of hydrocarbon generation and to look after their migration in the lithosphere up to the formation of deposits. Such model would allow one not only to describe and to explain these processes, but also to predict some features essential for the search and exploration of hydrocarbon fields in these regions and their classification. Enormous volumes of sediments accumulated over continental slopes and shelves are involved into the subduction zones in the course of overthrusting of island arcs onto continental margins. The weight of the overthrusting island arc substantially accelerates the subsiding of the continental margin. Crustal ground waters and hydrocarbons, capable to migration, begin to be squeezed out from the sedimentary material delivered to the waveguide zone under the island arc. The waters from the waveguide zone and the thermal water, released through dehydration of sediments and rocks of the former ocean crust and supplied from the deeper parts of the subduction zone, favor this process. Although the major portion of hydrocarbons is discharged and lost still in the body of the island arc itself

  16. A simple model for factory distribution: Historical effect in an industry city

    NASA Astrophysics Data System (ADS)

    Uehara, Takashi; Sato, Kazunori; Morita, Satoru; Maeda, Yasunobu; Yoshimura, Jin; Tainaka, Kei-ichi

    2016-02-01

    The construction and discontinuance processes of factories are complicated problems in sociology. We focus on the spatial and temporal changes of factories at Hamamatsu city in Japan. Real data indicate that the clumping degree of factories decreases as the density of factory increases. To represent the spatial and temporal changes of factories, we apply "contact process" which is one of cellular automata. This model roughly explains the dynamics of factory distribution. We also find "historical effect" in spatial distribution. Namely, the recent factories have been dispersed due to the past distribution during the period of economic bubble. This effect may be related to heavy shock in Japanese stock market.

  17. Factorial Structure of the Brief Symptom Inventory (BSI)-18 among Chinese Drug Users

    PubMed Central

    Wang, Jichuan; Kelly, Brian C; Liu, Tieqiao; Zhang, Guanbai; Hao, Wei

    2013-01-01

    BACKGROUND Although the Brief Symptom Inventory-18 (BSI-18) has been widely used for mental health screenings in both clinical and non-clinical populations, the validation of its application to Chinese populations has been very limited. The objective of this research is to assess the factorial structure of the BSI-18 within a Chinese drug using population. METHODS AND RESULTS A total sample of 303 drug users recruited via Respondent Driven Sampling (RDS) from Changsha, China was used for the study. Our results show: 1) The BSI-18 item scores are highly skewed; 2) With dichotomous items measures (1-problem at least moderately caused respondent discomfort during the past week; 0-otherwise), our findings support the designed 3-factor solution of the BSI-18 (somatization, depression, and anxiety); 3) The BSI-18 has a hierarchical factorial structure with 3 first-order factors and an underlying second-order factor (general psychological distress); 4) Tentative support should also be given to a single dimension of general psychological distress in Chinese drug using populations. Our study recommends a useful alternative approach for evaluating the factorial structure of the BSI-18 – i.e. CFA with dichotomous item measures. Both the total BSI-18 score and the three subscales (SOM, DEP, and ANX) can be used in applications of the BSI-18. CONCLUSION Overall, our findings suggest the BSI-18 is useful with Chinese drug users, and shows potential for use with non-Western and substance using populations more generally. PMID:23906998

  18. Microbially induced and microbially catalysed precipitation: two different carbonate factories

    NASA Astrophysics Data System (ADS)

    Meister, Patrick

    2016-04-01

    The landmark paper by Schlager (2003) has revealed three types of benthic carbonate production referred to as "carbonate factories", operative at different locations at different times in Earth history. The tropical or T-factory comprises the classical platforms and fringing reefs and is dominated by carbonate precipitation by autotrophic calcifying metazoans ("biotically controlled" precipitation). The cool or C-factory is also biotically controlled but via heterotrophic, calcifying metazoans in cold and deep waters at the continental margins. A further type is the mud-mound or M-factory, where carbonate precipitation is supported by microorganisms but not controlled by a specific enzymatic pathway ("biotically induced" precipitation). How exactly the microbes influence precipitation is still poorly understood. Based on recent experimental and field studies, the microbial influence on modern mud mound and microbialite growth includes two fundamentally different processes: (1) Metabolic activity of microbes may increase the saturation state with respect to a particular mineral phase, thereby indirectly driving the precipitation of the mineral phase: microbially induced precipitation. (2) In a situation, where a solution is already supersaturated but precipitation of the mineral is inhibited by a kinetic barrier, microbes may act as a catalyser, i.e. they lower the kinetic barrier: microbially catalysed precipitation. Such a catalytic effect can occur e.g. via secreted polymeric substances or specific chemical groups on the cell surface, at which the minerals nucleate or which facilitate mechanistically the bonding of new ions to the mineral surface. Based on these latest developments in microbialite formation, I propose to extend the scheme of benthic carbonate factories of Schlager et al. (2003) by introducing an additional branch distinguishing microbially induced from microbially catalysed precipitation. Although both mechanisms could be operative in a M-factory

  19. Polychlorinated dibenzo-p-dioxins and dibenzofurans and their association with cancer mortality among workers in one automobile foundry factory.

    PubMed

    Wang, Lihua; Weng, Shaofan; Wen, Sheng; Shi, Tingming; Sun, Gangtao; Zeng, Yuyu; Qi, Cheng; Chen, Weihong

    2013-01-15

    Polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) have been reported as possible carcinogenic hazards to humans. However, epidemiological studies on their carcinogenic roles are limited. The current study was designed to determine the concentrations and characteristics of PCDD/Fs and evaluate their association with cancer mortality in exposed workers in one automobile foundry factory. PCDD/F levels in factory and surrounding environment were analyzed through air and settling dust sampling. The cancer mortalities among workers in this foundry factory were calculated using data from a cohort study. The results showed that the PCDD/F concentrations of air in workplace ranged 0.36-2.25 pg World Health Organization-Toxic Equivalent (WHO-TEQ) Nm(-3) (average 1.01 pg WHO-TEQ Nm(-3)), which were 1.16-7.26 times higher than those outside the factory. The PCDD/F concentrations of settling dust in the workplace ranged 3.34-18.64 pg WHO-TEQ g(-1) (average 8.25 pg WHO-TEQ g(-1)), which were lower than those just outside the factory (average 16.13 pg WHO-TEQ g(-1)). Furthermore, a cohort study of workers in this factory with average follow-up of 24.52 years showed that cancer was the leading cause of death, with significant elevated mortality (standardized mortality ratio (SMR)=1.70, 95% confidence interval (CI): 1.35-2.13) among workers, when compared with Chinese national mortality. The cancer mortality among front-line workers was increased significantly (adjusted relative risk (RR)=1.73, 95% CI: 1.14-2.60), particularly among melting and casting workers, when compared with that among assistant workers. Our results indicated that there was a dose-response relationship between PCDD/F exposure and cancer mortality among foundry workers.

  20. A randomized trial of the clinical utility of genetic testing for obesity: Design and implementation considerations

    PubMed Central

    Wang, Catharine; Gordon, Erynn S.; Stack, Catharine B.; Liu, Ching-Ti; Norkunas, Tricia; Wawak, Lisa; Christman, Michael F.; Green, Robert C.; Bowen, Deborah J.

    2013-01-01

    Background Obesity rates in the United States have escalated in recent decades and present a major challenge in public health prevention efforts. Currently, testing to identify genetic risk for obesity is readily available through several direct-to-consumer companies. Despite the availability of this type of testing, there is a paucity of evidence as to whether providing people with personal genetic information on obesity risk will facilitate or impede desired behavioral responses. Purpose We describe the key issues in the design and implementation of a randomized controlled trial examining the clinical utility of providing genetic risk information for obesity. Methods Participants are being recruited from the Coriell Personalized Medicine Collaborative, an ongoing, longitudinal research cohort study designed to determine the utility of personal genome information in health management and clinical decision-making. The primary focus of the ancillary Obesity Risk Communication Study is to determine whether genetic risk information added value to traditional communication efforts for obesity, which are based on lifestyle risk factors. The trial employs a 2x2 factorial design in order to examine the effects of providing genetic risk information for obesity, alone or in combination with lifestyle risk information, on participants’ psychological responses, behavioral intentions, health behaviors, and weight. Results The factorial design generated four experimental arms based on communication of estimated risk to participants: 1) no risk feedback (control), 2) genetic risk only, 3) lifestyle risk only, 4) both genetic and lifestyle risk (combined). Key issues in study design pertained to the selection of algorithms to estimate lifestyle risk and determination of information to be provided to participants assigned to each experimental arm to achieve a balance between clinical standards and methodological rigor. Following the launch of the trial in September 2011