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Sample records for 3 db bandwidth

  1. [Double cladding ytterbium doped superfluorescence fiber source with 3 dB bandwidth reaching up to 80 nm].

    PubMed

    Han, Xu; Feng, Guo-Ying; Han, Jing-Hua; Wu, Chuan-Long; Zhou, Shou-Huan

    2012-11-01

    The present paper reports a double pass forward superfluorescent fiber source (SFS), which uses a length of large mode area double cladding ytterbium doped fiber as gain medium. The maximum output power of this SFS is 341 mW. With the output power between 201 and 341 mW, the 3dB bandwidth of this SFS was more than 80 nm. This is the widest 3 dB bandwidth obtained from ytterbium doped SFS. The output power of the SFS linearly increased with the increment of the pump source injected current. It's output power is not very high, but under normal circumstances, it could meet the needs of the SFS. From the energy level structure of ytterbium ions and the absorption cross-section/emission cross section of ytterbium ions in quartz substrate, the physical mechanisms responsible for superfluorescence were analyzed. This double-cladding ytterbium-doped superfluorescent fiber laser benefits from the superfluorescence radiation near 1 025 and 1 075 nm, so the superfluorescence with 3 dB bandwidth reaching up to 80 nm could be obtained. PMID:23387175

  2. A Fully Digital AGC System with 100MHz Bandwidth and 35dB Dynamic Range Power Detectors for DVB-S2 Application

    NASA Astrophysics Data System (ADS)

    Pu, Younggun; Lee, Kang-Yoon

    This paper presents a fully digital gain control system with a new high bandwidth and wide dynamic range power detector for DVB-S2 application. Because the peak-to-average power ratio (PAPR) of DVB-S2 system is so high and the settling time requirement is so stringent, the conventional closed-loop analog gain control scheme cannot be used. The digital gain control is necessary for the robust gain control and the direct digital interface with the baseband modem. Also, it has several advantages over the analog gain control in terms of the settling time and insensitivity to the process, voltage and temperature variation. In order to have a wide gain range with fine step resolution, a new AGC system is proposed. The system is composed of high-bandwidth digital VGAs, wide dynamic range power detectors with RMS detector, low power SAR type ADC, and a digital gain controller. To reduce the power consumption and chip area, only one SAR type ADC is used, and its input is time-interleaved based on four power detectors. Simulation and measurement results show that the new AGC system converges with gain error less than 0.25dB to the desired level within 10µs. It is implemented in a 0.18µm CMOS process. The measurement results of the proposed IF AGC system exhibit 80-dB gain range with 0.25-dB resolution, 8nV/\\\\!\\\\sqrt{Hz} input referred noise, and 5-dBm IIP3 at 60-mW power consumption. The power detector shows the 35dB dynamic range for 100MHz input.

  3. An inductorless CMOS programmable-gain amplifier with a > 3 GHz bandwidth for 60 GHz wireless transceivers

    NASA Astrophysics Data System (ADS)

    Wei, Zhu; Baoyong, Chi; Lixue, Kuang; Wen, Jia; Zhihua, Wang

    2014-10-01

    An inductorless wideband programmable-gain amplifier (PGA) for 60 GHz wireless transceivers is presented. To attain wideband characteristics, a modified Cherry—Hooper amplifier with a negative capacitive neutralization technique is employed as the gain cell while a novel circuit technique for gain adjustment is adopted; this technique can be universally applicable in wideband PGA design and greatly simplifying the design of wideband PGA. By cascading two gain cells and an output buffer stage, the PGA achieves the highest gain of 30 dB with the bandwidth much wider than 3 GHz. The PGA has been integrated into one whole 60 GHz wireless transceiver and implemented in the TSMC 65 nm CMOS process. The measurements on the receiver front-end show that the receiver front-end achieves an 18 dB variable gain range with a > 3 GHz bandwidth, which proves the proposed PGA achieves an 18 dB variable gain range with a bandwidth much wider than 3 GHz. The PGA consumes 10.7 mW of power from a 1.2-V supply voltage with a core area of only 0.025 mm2.

  4. 1.5-GHz voltage controlled oscillator with 3% tuning bandwidth using a two-pole DSBAR filter.

    PubMed

    Avramov, Ivan; Gilbert, Stephen R; Ruby, Rich

    2011-05-01

    First results on a novel voltage controlled oscillator (VCO) in the lower gigahertz range, featuring excellent phase noise and high power efficiency are presented. The heart of the VCO is a recently reported novel miniature two-pole decoupled stacked bulk acoustic resonator (DSBAR) filter. With its single 180° phase transition over the 1 dB bandwidth, linear phase, and maximum 1 dB insertion loss, it provides stable single-mode operation over 45 MHz (≈3%) of tuning bandwidth and has negligible heat dissipation when operated at incident power levels of 100 mW or greater. The 1.55-GHz laboratory VCO prototypes operate at 5 V supply voltage, 50 mA supply current, 15 dBm of output power, and >13% efficiency, demonstrating -84 and < -180 dBc/Hz phase noise suppression at 1 kHz carrier offset and in the thermal noise region, respectively. VCOs with cascaded DSBAR filters for further phase noise reduction are also demonstrated. PMID:21622047

  5. 1DB-2DB-3DB: One-, Two-, Three-Dimensional Diffusion Code System for Nuclear Reactor Analysis

    SciTech Connect

    2007-07-01

    1DB-2DB-3DB contains multipurpose, one-, two-, and three-dimensional diffusion theory codes for use in reactor analysis. 1DB is a one-dimensional (plane, cylinder, sphere), multigroup diffusion (and Sn) code. 2DB is a two-dimensional (X-Y, R-Z, R-theta, triangular), multigroup diffusion code. 3DB is a three-dimensional (X-Y-Z, R-theta-Z, Hex-Z), multigroup diffusion code. The codes can be used to: * Compute Keff using either a flux or an adjoint flux model, * Compute isotope burnup, and * Compute flux distributions for an extraneous source The codes read cross-section libraries in DTF format. Note that cross sections are not included in this package. This release replaces earlier versions previously distributed by RSICC as CCC-614/1DB, CCC-134/2DBS, and CCC-328/3DB (RSICC IDs: C614ALLCP00, C134U110800, and C328C000000).

  6. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic db/db Mice

    PubMed Central

    Yang, Xiu Hong; Pan, Yu; Zhan, Xiao Li; Zhang, Bao Long

    2016-01-01

    Epigallocatechin-3-gallate (EGCG), extracted from green tea, has been shown to have antioxidative activity. In the present study, we evaluated the effect of EGCG on the kidney function in db/db mice and also tried to investigate the underlying mechanism of the renoprotective effects of EGCG in both animals and cells. EGCG treatment could decrease the level of urinary protein, 8-iso-PGF2a, and Ang II. Moreover, EGCG could also change the level of several parameters associated with oxidative stress. In addition, the protein expression levels of AT-1R, p22-phox, p47-phox, p-ERK1/2, p-p38 MAPK, TGF-β1, and α-SMA in diabetic db/db mice were upregulated, and all of these symptoms were downregulated with the treatment of EGCG at 50 and 100 mg/kg/d. Furthermore, the pathological changes were ameliorated in db/db mice after EGCG treatment. HK-2 cell-based experiments indicated that EGCG could inhibit the expression of MAPK pathways, which is the downstream effector of Ang II mediated oxidative stress. All these results indicated that EGCG treatment could ameliorate changes of renal pathology and delay the progression of DKD by suppressing hyperglycemia-induced oxidative stress in diabetic db/db mice. PMID:27698952

  7. Epigallocatechin-3-gallate Attenuates Renal Damage by Suppressing Oxidative Stress in Diabetic db/db Mice

    PubMed Central

    Yang, Xiu Hong; Pan, Yu; Zhan, Xiao Li; Zhang, Bao Long

    2016-01-01

    Epigallocatechin-3-gallate (EGCG), extracted from green tea, has been shown to have antioxidative activity. In the present study, we evaluated the effect of EGCG on the kidney function in db/db mice and also tried to investigate the underlying mechanism of the renoprotective effects of EGCG in both animals and cells. EGCG treatment could decrease the level of urinary protein, 8-iso-PGF2a, and Ang II. Moreover, EGCG could also change the level of several parameters associated with oxidative stress. In addition, the protein expression levels of AT-1R, p22-phox, p47-phox, p-ERK1/2, p-p38 MAPK, TGF-β1, and α-SMA in diabetic db/db mice were upregulated, and all of these symptoms were downregulated with the treatment of EGCG at 50 and 100 mg/kg/d. Furthermore, the pathological changes were ameliorated in db/db mice after EGCG treatment. HK-2 cell-based experiments indicated that EGCG could inhibit the expression of MAPK pathways, which is the downstream effector of Ang II mediated oxidative stress. All these results indicated that EGCG treatment could ameliorate changes of renal pathology and delay the progression of DKD by suppressing hyperglycemia-induced oxidative stress in diabetic db/db mice.

  8. 3-D Television Without Glasses: On Standard Bandwidth

    NASA Astrophysics Data System (ADS)

    Collender, Robert B.

    1983-10-01

    This system for stereoscopic television uses relative camera to scene translating motion and does not require optical aids at the observer's eyes, presents a horizontal parallax (hologram like) 3-D full motion scene to a wide audience, has no dead zones or pseudo 3-D zones over the entire horizontal viewing field and operates on standard telecast signals requiring no changes to the television studio equipment or the home television antenna. The only change required at the receiving end is a special television projector. The system is compatible with pre-recorded standard color television signals. The cathode ray tube is eliminated by substituting an array of solid state charge couple device liquid crystal light valves which have the property to receive television fields in parallel from memory and which are arrayed in an arc for scanning purposes. The array contains a scrolled sequence of successive television frames which serve as the basis for 3-D horizontal viewing parallax. These light valves reflect polarized light with the degree of polarization made a function of the scene brightness. The array is optically scanned and the sequence rapidly projected onto a cylindrical concaved semi-specular screen that returns all of the light to a rapidly translating vertical "aerial" exit slit of light through which the audience views the reconstructed 3-D scene.

  9. Corrugated structure insertion for extending the SASE bandwidth up to 3% at the European XFEL

    NASA Astrophysics Data System (ADS)

    Zagorodnov, I.; Feng, G.; Limberg, T.

    2016-11-01

    The usage of x-ray free electron laser (XFEL) in femtosecond nanocrystallography involves sequential illumination of many small crystals of arbitrary orientation. Hence a wide radiation bandwidth will be useful in order to obtain and to index a larger number of Bragg peaks used for determination of the crystal orientation. Considering the baseline configuration of the European XFEL in Hamburg, and based on beam dynamics simulations, we demonstrate here that the usage of corrugated structures allows for a considerable increase in radiation bandwidth. Data collection with a 3% bandwidth, a few microjoule radiation pulse energy, a few femtosecond pulse duration, and a photon energy of 5.4 keV is possible. For this study we have developed an analytical modal representation of the short-range wake function of the flat corrugated structures for arbitrary offsets of the source and the witness particles.

  10. Bandwidth efficient coding for satellite communications

    NASA Technical Reports Server (NTRS)

    Lin, Shu; Costello, Daniel J., Jr.; Miller, Warner H.; Morakis, James C.; Poland, William B., Jr.

    1992-01-01

    An error control coding scheme was devised to achieve large coding gain and high reliability by using coded modulation with reduced decoding complexity. To achieve a 3 to 5 dB coding gain and moderate reliability, the decoding complexity is quite modest. In fact, to achieve a 3 dB coding gain, the decoding complexity is quite simple, no matter whether trellis coded modulation or block coded modulation is used. However, to achieve coding gains exceeding 5 dB, the decoding complexity increases drastically, and the implementation of the decoder becomes very expensive and unpractical. The use is proposed of coded modulation in conjunction with concatenated (or cascaded) coding. A good short bandwidth efficient modulation code is used as the inner code and relatively powerful Reed-Solomon code is used as the outer code. With properly chosen inner and outer codes, a concatenated coded modulation scheme not only can achieve large coding gains and high reliability with good bandwidth efficiency but also can be practically implemented. This combination of coded modulation and concatenated coding really offers a way of achieving the best of three worlds, reliability and coding gain, bandwidth efficiency, and decoding complexity.

  11. Temperature dependence of nu3 and nu4 bandwidths and complex refractive indices for crystalline methane

    NASA Astrophysics Data System (ADS)

    Ngoh, M. A.; Khanna, R. K.; Fox, K.

    1993-03-01

    Infrared spectra of thin films of pure CH4 have been measured for a range of temperatures from 22 to 68 K. The bandwidth for the fundamental nu3 near 3000/cm varies from 12.7 to 33.2/cm, while that for nu4 near 1300/cm varies from 6.2 to 16.0/cm. The real and imaginary parts of the index of refraction also exhibit significant dependence on temperature. These broadband measurements at low temperatures are useful for an understanding of clouds and hazes in the atmosphere of Uranus, clouds and ices in the atmosphere of Titan, and ices on the surfaces of Pluto and Triton.

  12. Wideband Array for C, X, and Ku-Band Applications with 5.3:1 Bandwidth

    NASA Technical Reports Server (NTRS)

    Novak, Markus H.; Volakis, John L.; Miranda, Felix A.

    2015-01-01

    Planar arrays that exploit strong intentional coupling between elements have allowed for very wide bandwidths in low-profile configurations. However, such designs also require complex impedance matching networks that must also be very compact. For many space applications, typically occurring at C-, X-, Ku-, and most recently at Ka-band, such designs require specialized and expensive fabrication techniques. To address this issue, a novel ultra-wideband array is presented, using a simplified feed network to reduce fabrication cost. The array operates from 3.5-18.5 GHz with VSWR less than 2.4 at broadside, and is of very low profile, having a total height of lambda/10 at the lowest frequency of operation. Validation is provided using a 64-element prototype array, fabricated using common Printed Circuit Board (PCB) technology. The low size, weight, and cost of this array make it attractive for space-borne applications.

  13. A 250 GHz Gyrotron with a 3 GHz Tuning Bandwidth for Dynamic Nuclear Polarization

    PubMed Central

    Barnes, Alexander B.; Nanni, Emilio A.; Herzfeld, Judith; Griffin, Robert G.; Temkin, Richard J.

    2012-01-01

    We describe the design and implementation of a novel tunable 250 GHz gyrotron oscillator with >10 W output power over most of a 3 GHz band and >35 W peak power. The tuning bandwidth and power are sufficient to generate a >1 MHz nutation frequency across the entire nitroxide EPR lineshape for cross effect DNP, as well as to excite solid effect transitions utilizing other radicals, without the need for sweeping the NMR magnetic field. Substantially improved tunability is achieved by implementing a long (23 mm) interaction cavity that can excite higher order axial modes by changing either the magnetic field of the gyrotron or the cathode potential. This interaction cavity excites the rotating TE5,2,q mode, and an internal mode converter outputs a high-quality microwave beam with >94% Gaussian content. The gyrotron was integrated into a DNP spectrometer, resulting in a measured DNP enhancement of 54 on the membrane protein bacteriorhodopsin. PMID:22743211

  14. Broadband sub-millimeter wave amplifer module with 38dB gain and 8.3dB noise figure

    NASA Astrophysics Data System (ADS)

    Sarkozy, S.; Leong, K.; Lai, R.; Leakey, R.; Yoshida, W.; Mei, X.; Lee, J.; Liu, P.-H.; Gorospe, B.; Deal, W. R.

    2011-05-01

    Broadband sub-millimeter wave technology has received significant attention for potential applications in security, medical, and military imaging. Despite theoretical advantages of reduced size, weight, and power compared to current millimeter-wave systems, sub-millimeter-wave systems are hampered by a fundamental lack of amplification with sufficient gain and noise figure properties. We report on the development of a sub-millimeter wave amplifier module as part of a broadband pixel operating from 300-350 GHz, biased off of a single 2V power supply. Over this frequency range, > 38 dB gain and < 8.3 dB noise figure are obtained and represent the current state-of-art performance capabilities. The prototype pixel chain consists of two WR3 waveguide amplifier blocks, and a horn antenna and diode detector. The low noise amplifier Sub-Millimeter-wave Monolithic Integrated Circuit (SMMIC) was originally developed under the DARPA SWIFT and THz Electronics programs and is based on sub 50 nm Indium Arsenide Composite Channel (IACC) transistor technology with a projected maximum oscillation frequency fmax > 1.0 THz. This development and demonstration may bring to life future sub-millimeter-wave and THz applications such as solutions to brown-out problems, ultra-high bandwidth satellite communication cross-links, and future planetary exploration missions.

  15. Got Bandwidth?

    ERIC Educational Resources Information Center

    Villano, Matt

    2009-01-01

    Video-heavy distance learning programs can put a strain on the campus network. This article describes how three institutions are managing bandwidth to ensure high-quality service for eLearning students.

  16. Beyond Bandwidth. . .

    ERIC Educational Resources Information Center

    Bruce, James D.

    2003-01-01

    Explores the implications and possibilities for colleges and universities as higher education goes "beyond bandwidth"--beyond the computing speed, innovative applications, and technological capabilities deployed globally today. (EV)

  17. High bandwidth deflection readout for atomic force microscopes.

    PubMed

    Steininger, Juergen; Bibl, Matthias; Yoo, Han Woong; Schitter, Georg

    2015-10-01

    This contribution presents the systematic design of a high bandwidth deflection readout mechanism for atomic force microscopes. The widely used optical beam deflection method is revised by adding a focusing lens between the cantilever and the quadrant photodetector (QPD). This allows the utilization of QPDs with a small active area resulting in an increased detection bandwidth due to the reduced junction capacitance. Furthermore the additional lens can compensate a cross talk between a compensating z-movement of the cantilever and the deflection readout. Scaling effects are analyzed to get the optimal spot size for the given geometry of the QPD. The laser power is tuned to maximize the signal to noise ratio without limiting the bandwidth by local saturation effects. The systematic approach results in a measured -3 dB detection bandwidth of 64.5 MHz at a deflection noise density of 62fm/√Hz.

  18. Narrow-Bandwidth Tunable Infrared Difference-Frequency Generation at High Repetition Rates in LilO(3).

    PubMed

    Goldberg, L S

    1975-03-01

    Difference-frequency generation was studied in LiIO(3) with a narrow-bandwidth tunable dye laser pumped at high pulse-repetition rates by a frequency-doubled Nd:YAG laser. Tunable infrared radiation of 0.1, cm(-1) bandwidth was generated from 1.25 mum to 1.60 mum and from 3.40 mum to 5.65 mum by mixing rhodamine B dye laser cavity radiation with the 1.064-mum or 532-nm output of the Nd:YAG laser.

  19. Comparison of steering angle and bandwidth for various phased array antenna concepts

    NASA Astrophysics Data System (ADS)

    Bonjour, Romain; Singleton, Matthew; Leuchtmann, Pascal; Leuthold, Juerg

    2016-08-01

    In this paper we compare different integratable ultra-fast tunable true-time delay concepts with respect to their performances in a phased array system. The performances of the schemes are assessed with respect to the supported range, i.e. the range within which beam steering for a given fractional bandwidth can be achieved with a gain flatness better than 3 dB. We also compare the array gain as of function of steering angle and fractional bandwidth.

  20. Holographic display system for dynamic synthesis of 3D light fields with increased space bandwidth product.

    PubMed

    Agour, Mostafa; Falldorf, Claas; Bergmann, Ralf B

    2016-06-27

    We present a new method for the generation of a dynamic wave field with high space bandwidth product (SBP). The dynamic wave field is generated from several wave fields diffracted by a display which comprises multiple spatial light modulators (SLMs) each having a comparably low SBP. In contrast to similar approaches in stereoscopy, we describe how the independently generated wave fields can be coherently superposed. A major benefit of the scheme is that the display system may be extended to provide an even larger display. A compact experimental configuration which is composed of four phase-only SLMs to realize the coherent combination of independent wave fields is presented. Effects of important technical parameters of the display system on the wave field generated across the observation plane are investigated. These effects include, e.g., the tilt of the individual SLM and the gap between the active areas of multiple SLMs. As an example of application, holographic reconstruction of a 3D object with parallax effects is demonstrated. PMID:27410593

  1. High efficiency and broad bandwidth grating coupler between nanophotonic waveguide and fibre

    NASA Astrophysics Data System (ADS)

    Zhu, Yu; Xu, Xue-Jun; Li, Zhi-Yong; Zhou, Liang; Han, Wei-Hua; Fan, Zhong-Chao; Yu, Yu-De; Yu, Jin-Zhong

    2010-01-01

    A high efficiency and broad bandwidth grating coupler between a silicon-on-insulator (SOI) nanophotonic waveguide and fibre is designed and fabricated. Coupling efficiencies of 46% and 25% at a wavelength of 1.55 μm are achieved by simulation and experiment, respectively. An optical 3 dB bandwidth of 45 nm from 1530 nm to 1575 nm is also obtained in experiment. Numerical calculation shows that a tolerance to fabrication error of 10 nm in etch depth is achievable. The measurement results indicate that the alignment error of ±2 μm results in less than 1 dB additional coupling loss.

  2. DPAL pump system exceeding 3kW at 766nm and 30 GHz bandwidth

    NASA Astrophysics Data System (ADS)

    Koenning, Tobias; McCormick, Dan; Irwin, David; Stapleton, Dean; Guiney, Tina; Patterson, Steve

    2016-03-01

    Due to their low quantum defect, diode pumped alkali metal vapor lasers (DPALs) offer the promise of scalability to very high average power levels while maintaining excellent beam quality. Research on DPALs has progressed to ever increasing power levels across multiple gain media species over the last years, necessitating pump power in the kW range. Each material requires a specific pump wavelength: near 852nm for cesium, 780nm for rubidium, 766nm for potassium, and 670nm for lithium atoms. The shorter pump wavelength below 800nm are outside the typical wavelength range for pump diodes developed for diode pumped solid state lasers (DPSS). The biggest challenge in pumping these materials efficiently is the need for maintaining the narrow gain media absorption band of approximately 0.01nm while greatly increasing power. Typical high power diode lasers achieve spectral widths around 3nm (FWHM) in the near infrared spectrum, but optical gratings may be used internal or external to the cavity to reduce the spectral width. Recently, experimental results have shown yet narrower line widths ranging from picometers at very low power levels to sub-100 picometers for water cooled stacks around 1kW of output power. The focus of this work is the development of a fiber-based pump system for potassium DPAL. The individual tasks are the development of high power 766nm chip material, a fiber-coupled module as a building block, and a scalable system design to address power requirements from hundreds of watts to tens of kilowatts. Results for a 3kW system achieving ~30GHz bandwidth at 766nm will be shown. Approaches for power-scaling and size reduction will be discussed.

  3. Characterization of red-near infrared transition for wheat and chickpea using 3 nm bandwidth data

    NASA Astrophysics Data System (ADS)

    Gupta, R. K.; Vijayan, D.; Prasad, T. S.

    2001-01-01

    Enhancement of space based capabilities to discriminate different crops and different varieties of a particular crop needs measurement of (i) the shift in red edge and (ii) the slope of the sudden rise of reflectance in 680 - 760 nm spectral region as a function of Days After Sowing (DAS). To develop the knowledge base for catering to the analysis of future space-based hyperspectral measurements, ground based measurements in 3 nm bandwidth in visible - near Infrared region together with corresponding Leaf Area Index (LAI) observations were taken over the Crop Growth Cycle (CGC) of Wheat and Chickpea. The red edge for wheat crop was at 679 nm for 25 DAS and reached the upper limit i.e., 693.7 nm at 84 DAS and thereafter shifted backward to 679 nm at 108 DAS. There was no change in red edge value of 684.9 nm during 40 to 49 DAS and of 687.8 nm during 55 to 71 DAS. The slope of Red to NIR transition for wheat varied from 0.457 to peak value of 0.784 during 25 to 71 DAS and thereafter decreased to 0.073 at 108 DAS. The peak of Red to Near Infrared (NIR) transition slope and Ratio Vegetation Index (RVI) occurred at the same time i.e., 71 DAS. However, the upper most value of red edge shift occurred at 84 DAS. Paper discusses the above aspects including role of mid point of Red to NIR transition, interrelationships among the Red-NIR transition Slope, Red Edge, LAI and RVI for wheat and chickpea.

  4. Design, Implementation and Applications of 3d Web-Services in DB4GEO

    NASA Astrophysics Data System (ADS)

    Breunig, M.; Kuper, P. V.; Dittrich, A.; Wild, P.; Butwilowski, E.; Al-Doori, M.

    2013-09-01

    The object-oriented database architecture DB4GeO was originally designed to support sub-surface applications in the geo-sciences. This is reflected in DB4GeO's geometric data model as well as in its import and export functions. Initially, these functions were designed for communication with 3D geological modeling and visualization tools such as GOCAD or MeshLab. However, it soon became clear that DB4GeO was suitable for a much wider range of applications. Therefore it is natural to move away from a standalone solution and to open the access to DB4GeO data by standardized OGC web-services. Though REST and OGC services seem incompatible at first sight, the implementation in DB4GeO shows that OGC-based implementation of web-services may use parts of the DB4GeO-REST implementation. Starting with initial solutions in the history of DB4GeO, this paper will introduce the design, adaptation (i.e. model transformation), and first steps in the implementation of OGC Web Feature (WFS) and Web Processing Services (WPS), as new interfaces to DB4GeO data and operations. Among its capabilities, DB4GeO can provide data in different data formats like GML, GOCAD, or DB3D XML through a WFS, as well as its ability to run operations like a 3D-to-2D service, or mesh-simplification (Progressive Meshes) through a WPS. We then demonstrate, an Android-based mobile 3D augmented reality viewer for DB4GeO that uses the Web Feature Service to visualize 3D geo-database query results. Finally, we explore future research work considering DB4GeO in the framework of the research group "Computer-Aided Collaborative Subway Track Planning in Multi-Scale 3D City and Building Models".

  5. P(3)DB: An Integrated Database for Plant Protein Phosphorylation.

    PubMed

    Yao, Qiuming; Bollinger, Curtis; Gao, Jianjiong; Xu, Dong; Thelen, Jay J

    2012-01-01

    Protein phosphorylation is widely recognized as the most widespread, enzyme-catalyzed post-translational modification in eukaryotes. In particular, plants have appropriated this signaling mechanism as evidenced by the twofold higher frequency of protein kinases within the genome compared to other eukaryotes. While all aspects of plant protein phosphorylation research have grown in the past 10 years; phosphorylation site mapping using high-resolution mass spectrometry has grown exponentially. In Arabidopsis alone there are thousands of experimentally determined phosphorylation sites. To archive these events in a user-intuitive format we have developed P(3)DB, the Plant Protein Phosphorylation Database (p3db.org). This database is a repository for plant protein phosphorylation site data, currently hosting information on 32,963 non-redundant sites collated from 23 experimental studies from six plant species. These data can be queried for a protein-of-interest using an integrated BLAST module to query similar sequences with known phosphorylation sites among the multiple plants currently investigated. The paper demonstrates how this resource can help identify functionally conserved phosphorylation sites in plants using a multi-system approach.

  6. Wideband Spectroscopy: The Design and Implementation of a 3 GHz Bandwidth, 8192 Channel, Polyphase Digital Spectrometer

    NASA Technical Reports Server (NTRS)

    Monroe, Ryan M.

    2011-01-01

    A family of state-of-the-art digital Fourier transform spectrometers has been developed, with a combination of high bandwidth and fine resolution unavailable elsewhere. Analog signals consisting of radiation emitted by constituents in planetary atmospheres or galactic sources are downconverted and subsequently digitized by a pair of interleaved Analog-to-Digital Converters, (ADC). This 6 Gsps (giga-sample per second) digital representation of the analog signal is then processed through an FPGA-based streaming Fast Fourier Transform (FFT), the key development described below. Digital spectrometers have many advantages over previously used analog spectrometers, especially in terms of accuracy and resolution, both of which are particularly important for the type of scientific questions to be addressed with next-generation radiometers. the implementation, results and underlying math for this spectrometer, as well as, potential for future extension to even higher bandwidth, resolution and channel orthogonality, needed to support proposed future advanced atmospheric science and radioastronomy, are discussed.

  7. A 32-GHz reflected-wave maser amplifier with wide instantaneous bandwidth

    NASA Technical Reports Server (NTRS)

    Shell, J.; Neff, D.

    1988-01-01

    An eight stage, 32 GHz reflected wave ruby maser was built. The maser operates in a 3 watt closed cycle refrigerator at 4.5 K and is capable of 21 dB of net gain with an instantaneous bandwidth of 400 MHz. The input noise temperature referred to the room temperature flange is approximately 21 K.

  8. T3DB: a comprehensively annotated database of common toxins and their targets.

    PubMed

    Lim, Emilia; Pon, Allison; Djoumbou, Yannick; Knox, Craig; Shrivastava, Savita; Guo, An Chi; Neveu, Vanessa; Wishart, David S

    2010-01-01

    In an effort to capture meaningful biological, chemical and mechanistic information about clinically relevant, commonly encountered or important toxins, we have developed the Toxin and Toxin-Target Database (T3DB). The T3DB is a unique bioinformatics resource that compiles comprehensive information about common or ubiquitous toxins and their toxin-targets into a single electronic repository. The database currently contains over 2900 small molecule and peptide toxins, 1300 toxin-targets and more than 33,000 toxin-target associations. Each T3DB record (ToxCard) contains over 80 data fields providing detailed information on chemical properties and descriptors, toxicity values, protein and gene sequences (for both targets and toxins), molecular and cellular interaction data, toxicological data, mechanistic information and references. This information has been manually extracted and manually verified from numerous sources, including other electronic databases, government documents, textbooks and scientific journals. A key focus of the T3DB is on providing 'depth' over 'breadth' with detailed descriptions, mechanisms of action, and information on toxins and toxin-targets. T3DB is fully searchable and supports extensive text, sequence, chemical structure and relational query searches, similar to those found in the Human Metabolome Database (HMDB) and DrugBank. Potential applications of the T3DB include clinical metabolomics, toxin target prediction, toxicity prediction and toxicology education. The T3DB is available online at http://www.t3db.org. PMID:19897546

  9. Frequency up-converted wide bandwidth piezoelectric energy harvester using mechanical impact

    NASA Astrophysics Data System (ADS)

    Halim, Miah A.; Khym, S.; Park, J. Y.

    2013-07-01

    This paper presents an impact based frequency up-converted wide bandwidth piezoelectric energy harvester in which two high frequency piezoelectric generating beams are struck at the same time by a low frequency driving beam having horizontally extended tip mass. Change of driving beam's effective stiffness during coupled vibration after impact allows the device to broaden the -3dB bandwidth to approximately 170% and to acquire more than 61% of the maximum power generation in the vicinity (from 7 to 10.5 Hz) of the -3 dB bandwidth region as well. The efficiency of electrical power transfer is increased to approximately 85%. Each generating beam produces 377 μW peak power at 14.5 Hz under 0.6 g acceleration with corresponding power density 58.8 μW cm-3.

  10. Self-imaging effect in photonic quasicrystal waveguides: Application to 3 dB power splitter for terahertz waves

    NASA Astrophysics Data System (ADS)

    Xu, Feixiang; Zou, Qiushun; Zhou, Quancheng; Wang, Tongbiao; Yu, Tianbao; Liu, Nianhua

    2016-05-01

    We report that self-imaging effect still can be achieved in photonic quasicrystal waveguides (PtQCWs) just as it does in photonic crystal waveguides. As a possible application of the results, a new kind of compact 3 dB PtQCWs-based power splitters based on this effect for terahertz waves with symmetric interference is presented and analyzed. The finite element method is used to calculate the distributions of stable-state electric field and evaluate transmission efficiency of these structures. The calculated results show that the proposed device provides a new compact model for exporting efficiently THz wave with a broad bandwidth to two channels averagely and can be extended to new designs of PtQCW devices.

  11. Bandwidth analysis of all-optical turbo-switch

    NASA Astrophysics Data System (ADS)

    Zhou, Peng; Yang, Xuelin; Hu, Xiaonan; Hu, Weisheng

    2015-01-01

    We propose and develop a frequency-domain model to analyze the bandwidth of all-optical turbo-switch. The model has taken the spatial inhomogeneity of semiconductor optical amplifier (SOA) into consideration for the first time. The simulations based on the model show that the 3-dB bandwidth of turbo-switch could reach up to ~270 GHz when the second SOA is oversaturated. However, the overshoot will be higher, which may result in the distortion of the output signal. There is a trade-off between the bandwidth and the flatness of frequency response characteristics for turbo-switch operation. In addition, the optimum position of the delay-interferometer (DI) is investigated, showing that the level of the overshoot is relatively lower if the DI is placed between the two SOAs.

  12. A reflected-wave ruby maser with K-band tuning range and large instantaneous bandwidth

    NASA Technical Reports Server (NTRS)

    Moore, C. R.; Clauss, R. C.

    1979-01-01

    A novel maser concept is outlined and a unique design described which permits wide bandwidth and waveguide tuning range by employing four stages cascaded via cryogenically cooled circulators. Theoretical considerations for gain, bandwidth, gain ripple, and noise temperature are included. Operated on a closed-cycle helium refrigerator with a superconducting persistence-mode magnet, the four-stage amplifier is tunable from 18.3 to 26.6 GHz with 30 dB of net gain and achieves 240 MHz of 3-dB bandwidth near the center of this band. The measured noise temperature is 13 + or - 2 K referred to the room-temperature input flange. Applications are foreseen utilizing cooled parametric downconverters and upconverters with this amplifier at IF to extend the low-noise performance up to millimeter frequencies and down to L-band for radio astronomy and planetary spacecraft communications.

  13. 47 CFR 95.633 - Emission bandwidth.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Emission bandwidth. 95.633 Section 95.633... SERVICES Technical Regulations Technical Standards § 95.633 Emission bandwidth. (a) The authorized bandwidth (maximum permissible bandwidth of a transmission) for emission type H1D, J1D, R1D, H3E, J3E or...

  14. 47 CFR 95.633 - Emission bandwidth.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Emission bandwidth. 95.633 Section 95.633... SERVICES Technical Regulations Technical Standards § 95.633 Emission bandwidth. (a) The authorized bandwidth (maximum permissible bandwidth of a transmission) for emission type H1D, J1D, R1D, H3E, J3E or...

  15. Carrier capture delay and modulation bandwidth in an edge-emitting quantum dot laser

    NASA Astrophysics Data System (ADS)

    Asryan, Levon V.; Wu, Yuchang; Suris, Robert A.

    2011-03-01

    We show that the carrier capture from the optical confinement layer into quantum dots (QDs) can strongly limit the modulation bandwidth ω-3 dB of a QD laser. As a function of the cross-section σn of carrier capture into a QD, ω-3 dB asymptotically approaches its highest value when σn→∞ (the case of instantaneous capture). With reducing σn, ω-3 dB decreases and becomes zero at a certain nonvanishing σnmin. The use of multiple-layers with QDs significantly improves the laser modulation response—ω-3 dB is considerably higher in a multilayer structure as compared to a single-layer structure at the same dc current.

  16. Frequency bandwidth and conversion loss of a semiconductor heterodyne receiver with phonon cooling of two-dimensional electrons

    SciTech Connect

    Shangina, E. L. Smirnov, K. V.; Morozov, D. V.; Kovalyuk, V. V.; Gol'tsman, G. N.; Verevkin, A. A.; Toropov, A. I.

    2010-11-15

    The temperature and concentration dependences of the frequency bandwidth of terahertz heterodyne AlGaAs/GaAs detectors based on hot electron phenomena with phonon cooling of two-dimensional electrons have been measured by submillimeter spectroscopy with a high time resolution. At a temperature of 4.2 K, the frequency bandwidth at a level of 3 dB (f{sub 3dB}) is varied from 150 to 250 MHz with a change in the concentration n{sub s} according to the power law f{sub 3dB} {proportional_to} n{sub s}{sup -0.5} due to the dominant contribution of piezoelectric phonon scattering. The minimum conversion loss of the semiconductor heterodyne detector is obtained in structures with a high carrier mobility ({mu} > 3 x 10{sup 5} cm{sup 2} V{sup -1} s{sup -1} at 4.2 K).

  17. Effect of internal optical loss on the modulation bandwidth of a quantum dot laser

    NASA Astrophysics Data System (ADS)

    Wu, Yuchang; Suris, Robert A.; Asryan, Levon V.

    2012-03-01

    We show that the internal optical loss, which increases with free-carrier density in the waveguide region, considerably reduces the modulation bandwidth ω-3 dB of a quantum dot laser. At a certain optimum value j0opt of the dc component of the injection current density, the maximum bandwidth ω-3dBmax is attained and the modulation response function becomes as flat as possible. With internal loss cross-section σint increasing and approaching its maximum tolerable value, ω-3dBmax decreases and becomes zero. As with j0opt, there also exists the optimum cavity length, at which ω-3 dB is highest; the larger is σint, the longer is the optimum cavity.

  18. Compact antenna arrays with wide bandwidth and low sidelobe levels

    DOEpatents

    Strassner, II, Bernd H.

    2014-09-09

    Highly efficient, low cost, easily manufactured SAR antenna arrays with lightweight low profiles, large instantaneous bandwidths and low SLL are disclosed. The array topology provides all necessary circuitry within the available antenna aperture space and between the layers of material that comprise the aperture. Bandwidths of 15.2 GHz to 18.2 GHz, with 30 dB SLLs azimuthally and elevationally, and radiation efficiencies above 40% may be achieved. Operation over much larger bandwidths is possible as well.

  19. 3-D readout-electronics packaging for high-bandwidth massively paralleled imager

    DOEpatents

    Kwiatkowski, Kris; Lyke, James

    2007-12-18

    Dense, massively parallel signal processing electronics are co-packaged behind associated sensor pixels. Microchips containing a linear or bilinear arrangement of photo-sensors, together with associated complex electronics, are integrated into a simple 3-D structure (a "mirror cube"). An array of photo-sensitive cells are disposed on a stacked CMOS chip's surface at a 45.degree. angle from light reflecting mirror surfaces formed on a neighboring CMOS chip surface. Image processing electronics are held within the stacked CMOS chip layers. Electrical connections couple each of said stacked CMOS chip layers and a distribution grid, the connections for distributing power and signals to components associated with each stacked CSMO chip layer.

  20. 3D interconnect architecture for high-bandwidth massively paralleled imager

    NASA Astrophysics Data System (ADS)

    Kwiatkowski, K.; Lyke, J. C.; Wojnarowski, R. J.; Beche, J.-F.; Fillion, R.; Kapusta, C.; Millaud, J.; Saia, R.; Wilke, M. D.

    2003-08-01

    The proton radiography group at LANL is developing a fast (5×10 6 frames/s or 5 megaframe/s) multi-frame imager for use in dynamic radiographic experiments with high-energy protons. The mega-pixel imager will acquire and process a burst of 32 frames captured at inter-frame time ˜200 ns. Real time signal processing and storage requirements for entire frames, of rapidly acquired pixels impose severe demands on the space available for the electronics in a standard monolithic approach. As such, a 3D arrangement of detector and circuit elements is under development. In this scheme, the readout integrated circuits (ROICs) are stacked vertically (like playing cards) into a cube configuration. Another die, a fully depleted pixel photo-diode focal plane array (FPA), is bump bonded to one of the edge surfaces formed by the resulting ROIC cube. Recently, an assembly of the proof-of-principle test cube and sensor has been completed.

  1. Circularly Polarized Double Layered Printed Hemispherical Helical Antenna with a Parasitic Wire for Bandwidth Enhancement

    NASA Astrophysics Data System (ADS)

    Latef, T. A.; Khamas, S. K.; Reza, Ahmed Wasif

    2014-07-01

    A helical antenna that is printed on a layered dielectric hemisphere has been studied when a parasitic helical wire is incorporated in the structure. Experimental and theoretical results demonstrate that the 3 dB axial ratio (AR) bandwidth can be enhanced by approximately 100% for optimized length and position of the parasitic wire. The analysis has been implemented using the method of moments (MoM), and good agreement has been achieved between computations and measurements.

  2. Banded all-optical OFDM super-channels with low-bandwidth receivers.

    PubMed

    Song, Binhuang; Zhu, Chen; Corcoran, Bill; Zhuang, Leimeng; Lowery, Arthur James

    2016-08-01

    We propose a banded all-optical orthogonal frequency division multiplexing (AO-OFDM) transmission system based on synthesising a number of truncated sinc-shaped subcarriers for each sub-band. This approach enables sub-band by sub-band reception and therefore each receiver's electrical bandwidth can be significantly reduced compared with a conventional AO-OFDM system. As a proof-of-concept experiment, we synthesise 6 × 10-Gbaud subcarriers in both conventional and banded AO-OFDM systems. With a limited receiver electrical bandwidth, the experimental banded AO-OFDM system shows 2-dB optical signal to noise ratio (OSNR) benefit over conventional AO-OFDM at the 7%-overhead forward error correction (FEC) threshold. After transmission over 800-km of single-mode fiber, ≈3-dB improvement in Q-factor can be achieved at the optimal launch power at a cost of increasing the spectral width by 14%. PMID:27505764

  3. Quantum Nondemolition Measurement of a Quantum Squeezed State Beyond the 3 dB Limit

    NASA Astrophysics Data System (ADS)

    Lei, C. U.; Weinstein, A. J.; Suh, J.; Wollman, E. E.; Kronwald, A.; Marquardt, F.; Clerk, A. A.; Schwab, K. C.

    2016-09-01

    We use a reservoir engineering technique based on two-tone driving to generate and stabilize a quantum squeezed state of a micron-scale mechanical oscillator in a microwave optomechanical system. Using an independent backaction-evading measurement to directly quantify the squeezing, we observe 4.7 ±0.9 dB of squeezing below the zero-point level surpassing the 3 dB limit of standard parametric squeezing techniques. Our measurements also reveal evidence for an additional mechanical parametric effect. The interplay between this effect and the optomechanical interaction enhances the amount of squeezing obtained in the experiment.

  4. Spectral bandwidth and ocular accommodation

    NASA Astrophysics Data System (ADS)

    Aggarwala, Karan R.; Kruger, Ekaterina S.; Mathews, Steven; Kruger, Philip B.

    1995-03-01

    Previous studies have suggested that targets illuminated by monochromatic (narrow-band) light are less effective in stimulating the eye to change its focus than are black-white (broadband) targets. The present study investigates the influence of target spectral bandwidth on the dynamic accommodation response in eight subjects. The fixation target was a 3.5-cycle / deg square-wave grating illuminated by midspectral light of various bandwidths [10, 40, and 80 nm and white (CIE Illuminant B)]. The target was moved sinusoidally toward and away from the eye, and accommodation responses were recorded and Fourier analyzed. Accommodative gain increases, and phase lag decreases, with increasing spectral bandwidth. Thus the eye focuses more accurately on targets of wider spectral bandwidth. The visual system appears to have the ability to analyze polychromatic blur to determine the state of focus of the eye for the purpose of guiding the accommodation response. blur, chromatic, focus, retinal image, spectral, wavelength

  5. Ultra-bandwidth polarization splitter based on soft glass dual-core photonic crystal fiber

    NASA Astrophysics Data System (ADS)

    Fan, Zhenkai; Li, Shu-Guang; Li, Jianshe; Wei, Zhiyi; Tian, Wenlong

    2015-08-01

    A novel ultra-bandwidth polarization splitter based on soft glass dual-core photonic crystal fiber (DC-PCF) is designed in this paper, which is analyzed through the finite element method (FEM). The coupling characteristics of the designed DC-PCF can be enhanced by a high refractive index As2S3 core. Numerical results show the ultra-bandwidths of the x- and y-polarization modes can reach to 86 nm and 60 nm as the extinction ratios better than -20 dB and -30 dB at the vicinity of the wavelength of 1.31 μm. The length of the designed soft glass DC-PCF is 52.29 mm and the extinction ratios of the x- and y-polarization modes are -85.57 dB and -56.81 dB at the wavelength of 1.31 μm, respectively. In addition, the designed splitter has a tolerance of ±10 nm in its all structure parameters, which make the design not sensitive to the perturbation during the fabrication process.

  6. Continuous variable quantum cryptography: beating the 3 dB loss limit.

    PubMed

    Silberhorn, Ch; Ralph, T C; Lütkenhaus, N; Leuchs, G

    2002-10-14

    We demonstrate that secure quantum key distribution systems based on continuous variable implementations can operate beyond the apparent 3 dB loss limit that is implied by the beam splitting attack. The loss limit was established for standard minimum uncertainty states such as coherent states. We show that, by an appropriate postselection mechanism, we can enter a region where Eve's knowledge on Alice's key falls behind the information shared between Alice and Bob, even in the presence of substantial losses.

  7. Plasmonic photodetector with terahertz electrical bandwidth

    NASA Astrophysics Data System (ADS)

    Mousavi, Saba Siadat; Stöhr, Andreas; Berini, Pierre

    2014-04-01

    We propose and investigate a surface plasmon photodetector concept, based on the enhancement of electrical near-field in low-defect, low-doped In0.53Ga0.47As detection volumes located in the gaps of an array of metal nanodipole antennas. We report enhancement in responsivity in the presence of nanodipoles and predict a maximum responsivity of ˜100 mA/W at wavelengths near 1550 nm. The 3 dB electrical bandwidth of the device is estimated based on its RC rise time and the hole transit time through the detection volume for the cases of conventional and ballistic transport in InGaAs and is found to range from ˜0.7 to 4 THz. Also, trends are observed relating the responsivity to the gap dimensions, revealing a trade-off between the field-enhancement in the gap and its volume, and leading to an optimum gap length producing the maximum responsivity.

  8. A Wide-Bandwidth, Low-Noise SIS Receiver Design for Millimeter and Submillimeter Wavelengths

    NASA Technical Reports Server (NTRS)

    Sumner, Matthew; Blain, Andrew; Harris, Andrew; Hu, Robert; LeDuc, Henry G.; Miller, David; Rice, Frank; Weinreb, Sander; Zmuidzinas, Jonas

    2004-01-01

    In principle, millimeter and submillimeter heterodyne receivers using state-of-the-art SIS detectors are capable of extremely large instantaneous bandwidths with noise temperatures within a few Kelvin of the quantum limit. We are applying modem design tools, such as 3D electromagnetic simulators and Caltech's SuperMix SIS analysis package, to develop a new generation of waveguide SIS mixers with very broad RF and IF bandwidths. Our initial design consists of a double-sideband mixer targeted for the 180- 300 GHz band that uses a single SIS junction excited by a full bandwidth, fixed-tuned waveguide probe on a silicon substrate. The IF output band, limited by the MMIC low-noise IF preamplifier, is 6-18 GHz, providing an instantaneous RF bandwidth of 24 GHz (double-sideband). The SIS mixer conversion loss is predicted to be no more than 1-2 dB (single-sideband) with mixer noise temperatures across the band within 10 Kelvin of the quantum limit. The single-sideband receiver noise temperature goal is 70 Kelvin. The wide instantaneous bandwidth and low noise will result in an instrument capable of a variety of important astrophysical observations beyond the capabilities of current instruments. Lab testing of the receiver will begin in the summer of 2002, and a demonstration on the CSO should occur in the spring of 2003.

  9. Chemical Industry Bandwidth Study

    SciTech Connect

    none,

    2006-12-01

    The Chemical Bandwidth Study provides a snapshot of potentially recoverable energy losses during chemical manufacturing. The advantage of this study is the use of "exergy" analysis as a tool for pinpointing inefficiencies.

  10. High-speed 405-nm superluminescent diode (SLD) with 807-MHz modulation bandwidth.

    PubMed

    Shen, Chao; Lee, Changmin; Ng, Tien Khee; Nakamura, Shuji; Speck, James S; DenBaars, Steven P; Alyamani, Ahmed Y; El-Desouki, Munir M; Ooi, Boon S

    2016-09-01

    III-nitride LEDs are fundamental components for visible-light communication (VLC). However, the modulation bandwidth is inherently limited by the relatively long carrier lifetime. In this letter, we present the 405 nm emitting superluminescent diode (SLD) with tilted facet design on semipolar GaN substrate, showing a broad emission of ~9 nm at 20 mW optical power. Owing to the fast recombination (τe<0.35 ns) through the amplified spontaneous emission, the SLD exhibits a significantly large 3-dB bandwidth of 807 MHz. A data rate of 1.3 Gbps with a bit-error rate of 2.9 × 10-3 was obtained using on-off keying modulation scheme, suggesting the SLD being a high-speed transmitter for VLC applications. PMID:27607634

  11. Glass Industry Bandwidth Analysis

    SciTech Connect

    Rue, David M.

    2006-07-01

    This is a study on energy use and potential savings, or "bandwidth" study, for several glassmaking processes. Intended to provide a realistic estimate of the potential amount of energy that can be saved in an industrial process, the "bandwidth" refers to the difference between the amount of energy that would be consumed in a process using commercially available technology versus the minimum amount of energy needed to achieve those same results.

  12. Industrial Glass Bandwidth Analysis

    SciTech Connect

    Rue, David M.; Servaites, James; Wolf, Warren

    2007-08-01

    This is a study on energy use and potential savings, or "bandwidth" study, for several glassmaking processes. Intended to provide a realistic estimate of the potential amount of energy that can be saved in an industrial process, the "bandwidth" refers to the difference between the amount of energy that would be consumed in a process using commercially available technology versus the minimum amount of energy needed to achieve those same results.

  13. The Goodrich 3rd generation DB-110 system: successful flight test on the F-16 aircraft

    NASA Astrophysics Data System (ADS)

    Lange, Davis; Iyengar, Mrinal; Maver, Larry; Dyer, Gavin; Francis, John

    2007-04-01

    The 3rd Generation Goodrich DB-110 system provides users with a three (3) field-of-view high performance Airborne Reconnaissance capability that incorporates a dual-band day and nighttime imaging sensor, a real time recording and a real time data transmission capability to support long range, medium range, and short range standoff and over-flight mission scenarios, all within a single pod. Goodrich developed their 3rd Generation Airborne Reconnaissance Pod for operation on a range of aircraft types including F-16, F-15, F-18, Euro-fighter and older aircraft such as the F-4, F-111, Mirage and Tornado. This system upgrades the existing, operationally proven, 2nd generation DB-110 design with enhancements in sensor resolution, flight envelope and other performance improvements. Goodrich recently flight tested their 3rd Generation Reconnaissance System on a Block 52 F-16 aircraft with first flight success and excellent results. This paper presents key highlights of the system and presents imaging results from flight test.

  14. Simulation of solidly mounted plate wave resonator with wide bandwidth using 0-th shear horizontal mode in LiNbO3 plate

    NASA Astrophysics Data System (ADS)

    Kadota, Michio; Tanaka, Shuji

    2015-07-01

    A cognitive radio system using a vacant frequency band of digital TV channels (TV white space) requires a tunable filter with wide tunable ranges of center frequency and bandwidth. An ultra-wideband resonator is a key device to implement the tunable filter, because the tunable range is limited by the bandwidth (BW) of the resonators. A 0-th shear horizontal (SH0) mode plate wave resonator using an ultra-thin LiNbO3 plate is known to have a large electromechanical coupling factor, i.e., a large BW, but the structural fragility of the ultra-thin LiNbO3 plate is problematic. In this study, the feasibility of solidly mounted resonator type SH0 mode plate wave resonator was investigated systematically by finite element method simulation. The design parameters including the Euler angle, thickness of a LiNbO3 plate, and the material and thickness of an interdigital transducer were optimized. With the best design, a BW as wide as 26% is obtained.

  15. High-speed 850 nm VCSELs with 28 GHz modulation bandwidth for short reach communication

    NASA Astrophysics Data System (ADS)

    Westbergh, Petter; Safaisini, Rashid; Haglund, Erik; Gustavsson, Johan S.; Larsson, Anders; Joel, Andrew

    2013-03-01

    We present results from our new generation of high performance 850 nm oxide confined vertical cavity surface-emitting lasers (VCSELs). With devices optimized for high-speed operation under direct modulation, we achieve record high 3dB modulation bandwidths of 28 GHz for ~4 μm oxide aperture diameter VCSELs, and 27 GHz for devices with a ~7 μm oxide aperture diameter. Combined with a high-speed photoreceiver, the ~7 μm VCSEL enables error-free transmission at data rates up to 47 Gbit/s at room temperature, and up to 40 Gbit/s at 85°C.

  16. 47 CFR 90.209 - Bandwidth limitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... bandwidth (kHz) Below 25 2 25-50 20 20 72-76 20 20 150-174 17.5 1,3 20/11.25/6 216-220 5 6.25 20/11.25/6 220... kHz. The maximum authorized bandwidth for type A3E emission is 8 kHz. (2) For operations below 25 MHz utilizing J3E emission, the bandwidth occupied by the emission shall not exceed 3000 Hz....

  17. S3DB core: a framework for RDF generation and management in bioinformatics infrastructures

    PubMed Central

    2010-01-01

    Background Biomedical research is set to greatly benefit from the use of semantic web technologies in the design of computational infrastructure. However, beyond well defined research initiatives, substantial issues of data heterogeneity, source distribution, and privacy currently stand in the way towards the personalization of Medicine. Results A computational framework for bioinformatic infrastructure was designed to deal with the heterogeneous data sources and the sensitive mixture of public and private data that characterizes the biomedical domain. This framework consists of a logical model build with semantic web tools, coupled with a Markov process that propagates user operator states. An accompanying open source prototype was developed to meet a series of applications that range from collaborative multi-institution data acquisition efforts to data analysis applications that need to quickly traverse complex data structures. This report describes the two abstractions underlying the S3DB-based infrastructure, logical and numerical, and discusses its generality beyond the immediate confines of existing implementations. Conclusions The emergence of the "web as a computer" requires a formal model for the different functionalities involved in reading and writing to it. The S3DB core model proposed was found to address the design criteria of biomedical computational infrastructure, such as those supporting large scale multi-investigator research, clinical trials, and molecular epidemiology. PMID:20646315

  18. Low-bandwidth authentication.

    SciTech Connect

    Donnelly, Patrick Joseph; McIver, Lauren; Gaines, Brian R.; Anderson, Erik; Collins, Michael Joseph; Thomas,Kurt Adam; McDaniel, Austin

    2007-09-01

    Remotely-fielded unattended sensor networks generally must operate at very low power--in the milliwatt or microwatt range--and thus have extremely limited communications bandwidth. Such sensors might be asleep most of the time to conserve power, waking only occasionally to transmit a few bits. RFID tags for tracking or material control have similarly tight bandwidth constraints, and emerging nanotechnology devices will be even more limited. Since transmitted data is subject to spoofing, and since sensors might be located in uncontrolled environments vulnerable to physical tampering, the high-consequence data generated by such systems must be protected by cryptographically sound authentication mechanisms; but such mechanisms are often lacking in current sensor networks. One reason for this undesirable situation is that standard authentication methods become impractical or impossible when bandwidth is severely constrained; if messages are small, a standard digital signature or HMAC will be many times larger than the message itself, yet it might be possible to spare only a few extra bits per message for security. Furthermore, the authentication tags themselves are only one part of cryptographic overhead, as key management functions (distributing, changing, and revoking keys) consume still more bandwidth. To address this problem, we have developed algorithms that provide secure authentication while adding very little communication overhead. Such techniques will make it possible to add strong cryptographic guarantees of data integrity to a much wider range of systems.

  19. Broad Bandwidth Telecommunications Systems.

    ERIC Educational Resources Information Center

    Sodolski, John

    Broad bandwidth transmission systems have been around for years. They include microwave, assorted cable systems, and recently, satellites. With the exception of some privately owned systems, broadband services have been furnished by the common carriers. Recently, a new element has been added--Cable Antenna Television (CATV) distribution systems.…

  20. A Low Cross-Polarization Smooth-Walled Horn with Improved Bandwidth

    NASA Technical Reports Server (NTRS)

    Zeng, Lingzhen; Bennette, Charles L.; Chuss, David T.; Wollack, Edward J.

    2009-01-01

    Corrugated feed horns offer excellent beam symmetry, main beam efficiency, and cross-polar response over wide bandwidths, but can be challenging to fabricate. An easier-to-manufacture smooth-walled feed is explored that approximates these properties over a finite bandwidth. The design, optimization and measurement of a monotonically-profiled, smooth-walled scalar feedhorn with a diffraction-limited approx. 14deg FWHM beam is presented. The feed was demonstrated to have low cross polarization (<-30 dB) across the frequency range 33-45 GHz (30% fractional bandwidth). A power reflection below -28 dB was measured across the band.

  1. A Low Cross-Polarization Smooth-Walled Horn with Improved Bandwidth

    NASA Technical Reports Server (NTRS)

    Zeng, Lingzhen; Bennett, Charles L.; Chuss, David T.; Wollack, Edward J.

    2009-01-01

    Corrugated feed horns offer excellent beam symmetry, main beam efficiency, and cross-polar response over wide bandwidths, but can be challenging to fabricate. An easier-to-manufacture smooth-walled feed is explored that approximates these properties over a finite bandwidth. The design, optimization and measurement of a monotonically-profiled, smooth-walled scalar feedhorn with a diffraction-limited approximately 7 degrees full width at half maximum (FWHM) is presented. The feed was demonstrated to have low cross polarization (<-30 dB) across the frequency range 33-45 GHz (30% fractional bandwidth). A return loss better than -28 dB was measured across the band.

  2. Final Report on LDRD Project: High-Bandwidth Optical Data Interconnects for Satellite Applications

    SciTech Connect

    SERKLAND, DARWIN K.; GEIB, KENT M.; BLANSETT, ETHAN L.; KARPEN, GARY D.; PEAKE, GREGORY M.; HARGETT, TERRY; MONTANO, VICTORIA; SULLIVAN, CHARLES T.; ALLERMAN, ANDREW A.; RIENSTRA, JEFFREY L.

    2003-04-01

    This report describes the research accomplishments achieved under the LDRD Project ''High-Bandwidth Optical Data Interconnects for Satellite Applications.'' The goal of this LDRD has been to address the future needs of focal-plane-array (FPA) sensors by exploring the use of high-bandwidth fiber-optic interconnects to transmit FPA signals within a satellite. We have focused primarily on vertical-cavity surface-emitting laser (VCSEL) based transmitters, due to the previously demonstrated immunity of VCSELs to total radiation doses up to 1 Mrad. In addition, VCSELs offer high modulation bandwidth (roughly 10 GHz), low power consumption (roughly 5 mW), and high coupling efficiency (greater than -3dB) to optical fibers. In the first year of this LDRD, we concentrated on the task of transmitting analog signals from a cryogenic FPA to a remote analog-to-digital converter. In the second year, we considered the transmission of digital signals produced by the analog-to-digital converter to a remote computer on the satellite. Specifically, we considered the situation in which the FPA, analog-to-digital converter, and VCSEL-based transmitter were all cooled to cryogenic temperatures. This situation requires VCSELs that operate at cryogenic temperature, dissipate minimal heat, and meet the electrical drive requirements in terms of voltage, current, and bandwidth.

  3. QUASI-OPTICAL 3-dB HYBRID FOR FUTURE HIGH-ENERGY ACCELERATORS

    SciTech Connect

    Jay L. Hirshfield

    2005-12-15

    Phase-controlled wave combiners-commutators and isolators for protecting rf sources against reflection from the accelerating structure can be built using a 3-dB hybrid built around a metallic grating used in a ''magic-Y'' configuration. Models of the magic-Y were designed and tested, both at 34.272 GHz using the Omega-P Ka-band magnicon, and at 11.424 GHz using the Omega-P/NRL X-band magnicon. All elements of the magic-Y were optimized analytically and numerically. A non-vacuum 34 GHz model of the magic Y was built and tested experimentally at a low power. An engineering design for the high power (vacuum) compressor was configured. Similar steps were taken for the 11-GHz version.

  4. Draft Genome Sequences of Two Clostridium botulinum Group II (Nonproteolytic) Type B Strains (DB-2 and KAPB-3).

    PubMed

    Petronella, Nicholas; Kenwell, Robyn; Pagotto, Franco; Pightling, Arthur W

    2014-01-01

    Clostridium botulinum is important for food safety and studies of neurotoxins associated with human botulism. We present the draft genome sequences of two strains belonging to group II type B: one collected from Pacific Ocean sediments (DB-2) and another obtained during a botulism outbreak (KAPB-3). PMID:25377702

  5. Simultaneous full-field 3-D vibrometry of the human eardrum using spatial-bandwidth multiplexed holography

    NASA Astrophysics Data System (ADS)

    Khaleghi, Morteza; Guignard, Jérémie; Furlong, Cosme; Rosowski, John J.

    2015-11-01

    Holographic interferometric methods typically require the use of three sensitivity vectors in order to obtain three-dimensional (3-D) information. Methods based on multiple directions of illumination have limited applications when studying biological tissues that have temporally varying responses such as the tympanic membrane (TM). Therefore, to measure 3-D displacements in such applications, the measurements along all the sensitivity vectors have to be done simultaneously. We propose a multiple-illumination directions approach to measure 3-D displacements from a single-shot hologram that contains displacement information from three sensitivity vectors. The hologram of an object of interest is simultaneously recorded with three incoherently superimposed pairs of reference and object beams. The incident off-axis angles of the reference beams are adjusted such that the frequency components of the multiplexed hologram are completely separate. Because of the differences in the directions and wavelengths of the reference beams, the positions of each reconstructed image corresponding to each sensitivity vector are different. We implemented a registration algorithm to accurately translate individual components of the hologram into a single global coordinate system to calculate 3-D displacements. The results include magnitudes and phases of 3-D sound-induced motions of a human cadaveric TM at several excitation frequencies showing modal and traveling wave motions on its surface.

  6. Simultaneous full-field 3-D vibrometry of the human eardrum using spatial-bandwidth multiplexed holography

    PubMed Central

    Khaleghi, Morteza; Guignard, Jérémie; Furlong, Cosme; Rosowski, John J.

    2015-01-01

    Abstract. Holographic interferometric methods typically require the use of three sensitivity vectors in order to obtain three-dimensional (3-D) information. Methods based on multiple directions of illumination have limited applications when studying biological tissues that have temporally varying responses such as the tympanic membrane (TM). Therefore, to measure 3-D displacements in such applications, the measurements along all the sensitivity vectors have to be done simultaneously. We propose a multiple-illumination directions approach to measure 3-D displacements from a single-shot hologram that contains displacement information from three sensitivity vectors. The hologram of an object of interest is simultaneously recorded with three incoherently superimposed pairs of reference and object beams. The incident off-axis angles of the reference beams are adjusted such that the frequency components of the multiplexed hologram are completely separate. Because of the differences in the directions and wavelengths of the reference beams, the positions of each reconstructed image corresponding to each sensitivity vector are different. We implemented a registration algorithm to accurately translate individual components of the hologram into a single global coordinate system to calculate 3-D displacements. The results include magnitudes and phases of 3-D sound-induced motions of a human cadaveric TM at several excitation frequencies showing modal and traveling wave motions on its surface. PMID:25984986

  7. Dynamic characteristics of 410 nm semipolar (20 2 ¯ 1 ¯) III-nitride laser diodes with a modulation bandwidth of over 5 GHz

    NASA Astrophysics Data System (ADS)

    Lee, Changmin; Zhang, Chong; Becerra, Daniel L.; Lee, Seunggeun; Forman, Charles A.; Oh, Sang Ho; Farrell, Robert M.; Speck, James S.; Nakamura, Shuji; Bowers, John E.; DenBaars, Steven P.

    2016-09-01

    The dynamic characteristics of III-nitride multi-quantum well laser diodes (LDs) emitting at 410 nm were investigated. LDs were grown on semipolar (20 2 ¯ 1 ¯) bulk GaN substrates and fabricated into devices with cavity lengths ranging from 900 nm to 1800 nm. A 3-dB bandwidth of 5 GHz and 5 Gbit/s direct modulation with on-off keying were demonstrated, which were limited by the bandwidth of the photodetector used for the measurements. The differential gain of the LDs was determined to be 2.5 ± 0.5 × 10-16 cm2 by comparing the slope efficiency for different cavity lengths. Analysis of the frequency response showed that the K-factor, the gain compression factor, and the intrinsic maximum bandwidth were 0.33 ns, 7.4 × 10-17 cm3, and 27 GHz, respectively.

  8. Flat-top bandpass microwave photonic filter with tunable bandwidth and center frequency based on a Fabry-Pérot semiconductor optical amplifier.

    PubMed

    Jiang, Fan; Yu, Yuan; Cao, Tong; Tang, Haitao; Dong, Jianji; Zhang, Xinliang

    2016-07-15

    We propose a flat-top bandpass microwave photonic filter (MPF) with flexible tunability of the bandwidth and center frequency based on optical nonlinearities in a Fabry-Pérot semiconductor optical amplifier (FP-SOA). Phase-inverted modulation induced by cross-gain modulation (XGM) and optical spectral broadening induced by self-phase modulation (SPM) are exploited to achieve flat-top and bandwidth tuning, respectively. Wideband and continuous tuning of the center frequency is achieved by altering the bias current of the FP-SOA. Experimental results demonstrate a flat-top single-passband MPF with its center frequency tunable from 6.0 to 18.3 GHz by adjusting the bias current from 54.05 to 107.85 mA. The 3-dB bandwidth of the passband when centered at 10.0 GHz is shown to be variable from 680 to 1.43 GHz, by increasing the injected optical power from -1 to +5  dBm. During the bandwidth tuning, the amplitude ripple within the passband is maintained at less than ±0.5  dB. Excellent main to secondary sidelobe ratio exceeding 45 dB is achieved when the MPF is centered at 18.3 GHz.

  9. Flat-top bandpass microwave photonic filter with tunable bandwidth and center frequency based on a Fabry-Pérot semiconductor optical amplifier.

    PubMed

    Jiang, Fan; Yu, Yuan; Cao, Tong; Tang, Haitao; Dong, Jianji; Zhang, Xinliang

    2016-07-15

    We propose a flat-top bandpass microwave photonic filter (MPF) with flexible tunability of the bandwidth and center frequency based on optical nonlinearities in a Fabry-Pérot semiconductor optical amplifier (FP-SOA). Phase-inverted modulation induced by cross-gain modulation (XGM) and optical spectral broadening induced by self-phase modulation (SPM) are exploited to achieve flat-top and bandwidth tuning, respectively. Wideband and continuous tuning of the center frequency is achieved by altering the bias current of the FP-SOA. Experimental results demonstrate a flat-top single-passband MPF with its center frequency tunable from 6.0 to 18.3 GHz by adjusting the bias current from 54.05 to 107.85 mA. The 3-dB bandwidth of the passband when centered at 10.0 GHz is shown to be variable from 680 to 1.43 GHz, by increasing the injected optical power from -1 to +5  dBm. During the bandwidth tuning, the amplitude ripple within the passband is maintained at less than ±0.5  dB. Excellent main to secondary sidelobe ratio exceeding 45 dB is achieved when the MPF is centered at 18.3 GHz. PMID:27420520

  10. ABB: active bandwidth broker

    NASA Astrophysics Data System (ADS)

    Wong, Kason; Law, Eddie

    2001-07-01

    In this paper, we shall discuss a novel design on the policy-based management for the Internet. This design deploys the concept of active networking. As opposed to the traditional network design, active network empowers network node with the ability to manipulate data and program code in packets, and configure the network properties according to the needs of different applications. The policy-based management can control network routers in order to realize end-to-end Quality of Service (QoS), such as differentiated and integrated services, across the Internet. For the moment, the Internet Engineering Task Force (IETF) has defined the framework of the policy-based management. It employs a simple client/server model that uses Common Open Policy Service (COPS) protocol to facilitate policy management and control. Our design of Active Bandwidth Broker (ABB) belongs to an active application. Our goals are to distribute centralized workload of the policy-based management over multiple active nodes in the active networks, introduce mobility of the bandwidth brokers, and allows load sharing to the policy-based management. This results a network-wide intelligent, highly available, and consistent QoS control that allows performance protection for voice, video and Internet business application while reducing costs for growing networks.

  11. Loudness of subcritical sounds as a function of bandwidth, center frequency, and level.

    PubMed

    Hots, J; Rennies, J; Verhey, J L

    2014-03-01

    Level differences at equal loudness between band-pass noise and pure tones with a frequency equal to the center frequency of the noise were measured in normal-hearing listeners using a loudness matching procedure. The center frequencies were 750, 1500, and 3000 Hz and noise bandwidths from 5 to 1620 Hz were used. The level of the reference pure tone was 30, 50, or 70 dB. For all center frequencies and reference levels, the level at equal loudness was close to 0 dB for the narrowest bandwidth, increased with bandwidth for bandwidths smaller than the critical bandwidth, and decreased for bandwidths larger than the critical bandwidth. For bandwidths considerably larger than the critical bandwidth, the level difference was negative. The maximum positive level difference was measured for a bandwidth close to the critical bandwidth. This maximum level difference decreased with increasing reference level. A similar effect was found when the level differences were derived from data of an additional categorical loudness scaling experiment. The results indicate that the decrease of loudness at equal level with increasing subcritical bandwidth is a common property of the auditory system which is not taken into account in current loudness models. PMID:24606270

  12. Application of 3D Spatio-Temporal Data Modeling, Management, and Analysis in DB4GEO

    NASA Astrophysics Data System (ADS)

    Kuper, P. V.; Breunig, M.; Al-Doori, M.; Thomsen, A.

    2016-10-01

    Many of todaýs world wide challenges such as climate change, water supply and transport systems in cities or movements of crowds need spatio-temporal data to be examined in detail. Thus the number of examinations in 3D space dealing with geospatial objects moving in space and time or even changing their shapes in time will rapidly increase in the future. Prominent spatio-temporal applications are subsurface reservoir modeling, water supply after seawater desalination and the development of transport systems in mega cities. All of these applications generate large spatio-temporal data sets. However, the modeling, management and analysis of 3D geo-objects with changing shape and attributes in time still is a challenge for geospatial database architectures. In this article we describe the application of concepts for the modeling, management and analysis of 2.5D and 3D spatial plus 1D temporal objects implemented in DB4GeO, our service-oriented geospatial database architecture. An example application with spatio-temporal data of a landfill, near the city of Osnabrück in Germany demonstrates the usage of the concepts. Finally, an outlook on our future research focusing on new applications with big data analysis in three spatial plus one temporal dimension in the United Arab Emirates, especially the Dubai area, is given.

  13. Extended high-frequency bandwidth improves reception of speech in spatially separated masking speech

    PubMed Central

    Levy, Suzanne Carr; Freed, Daniel J.; Nilsson, Michael; Moore, Brian C.J.; Puria, Sunil

    2015-01-01

    Objectives The hypothesis that extending the audible frequency bandwidth beyond the range currently implemented in most hearing aids can improve speech understanding was tested for normal-hearing and hearing-impaired participants using target sentences and spatially separated masking speech. Design The Hearing in Noise Test (HINT) speech corpus was re-recorded and four masking talkers were recorded at a sample rate of 44.1 kHz. All talkers were male native speakers of American English. Reception threshold for Sentences (RTS) were measured in two spatial configurations. In the asymmetric configuration, the target was presented from −45° azimuth and two colocated masking talkers were presented from +45° azimuth. In the diffuse configuration, the target was presented from 0° azimuth and four masking talkers were each presented from a different azimuth: +45°, +135°, −135°, and −45°. The new speech sentences, masking materials and configurations, collectively termed the ‘Hearing in Speech Test (HIST)’, were presented using lowpass filter cutoff frequencies of 4, 6, 8, and 10 kHz. For the normal-hearing participants, stimuli were presented in the sound field using loudspeakers. For the hearing-impaired participants, the spatial configurations were simulated using earphones, and a multi-band wide dynamic range compressor with a modified CAM2 fitting algorithm was used to compensate for each participant’s hearing loss. Results For the normal-hearing participants (N=24, mean age 40 years), the RTS improved significantly by 3.0 dB when the bandwidth was increased from 4 to 10 kHz, and a significant improvement of 1.3 dB was obtained from extending the bandwidth from 6 to 10 kHz, in both spatial configurations. Hearing-impaired participants (N=25, mean age 71 years) also showed a significant improvement in RTS with extended bandwidth, but the effect was smaller than for the normal-hearing participants. The mean decrease in RTS when the bandwidth was

  14. Asymmetric MQW semiconductor optical amplifier with low-polarization sensitivity of over 90-nm bandwidth

    NASA Astrophysics Data System (ADS)

    Nkanta, Julie E.; Maldonado-Basilio, Ramón; Abdul-Majid, Sawsan; Zhang, Jessica; Hall, Trevor J.

    2013-12-01

    An exhausted capacity of current Passive Optical Networks has been anticipated as bandwidth-hungry applications such as HDTV and 3D video become available to end-users. To enhance their performance, the next generation optical access networks have been proposed, using optical carriers allocated within the E-band (1360-1460 nm). It is partly motivated by the low-water peak fiber being manufactured by Corning. At these wavelengths, choices for low cost optical amplifiers, with compact size, low energy consumption and feasibility for integration with other optoelectronic components are limited, making the semiconductor optical amplifiers (SOA) a realistic solution. An experimental characterization of a broadband and low polarization sensitive asymmetric multi quantum well (MQW) SOA operating in the E-band is reported. The SOA device is composed of nine 6 nm In1-xGaxAsyP1-y 0.2% tensile strained asymmetric MQW layers sandwiched between nine latticed matched 6 nm InGaAsP barrier layers. The active region is grown on an n-doped InP substrate and buried by p-doped InGaAsP layers. The SOA devices have 7-degrees tilt anti-reflected coated facets, with 2 μm ridge width, and a cavity length of 900 μm. For input powers of -10 dBm and -20 dBm, a maximum gain of 20 dB at 1360 nm with a polarization insensitivity under 3 dB for over 90 nm bandwidth is measured. Polarization sensitivity of less than 0.5 dB is observed for some wavelengths. Obtained results indicate a promising SOA with broadband amplification, polarization insensitivity and high gain. These SOAs were designed and characterized at the Photonics Technology Laboratory, University of Ottawa, Canada.

  15. Influence of Reduced Graphene Oxide on Effective Absorption Bandwidth Shift of Hybrid Absorbers.

    PubMed

    Ameer, Shahid; Gul, Iftikhar Hussain

    2016-01-01

    The magnetic nanoparticle composite NiFe2O4 has traditionally been studied for high-frequency microwave absorption with marginal performance towards low-frequency radar bands (particularly L and S bands). Here, NiFe2O4 nanoparticles and nanohybrids using large-diameter graphene oxide (GO) sheets are prepared via solvothermal synthesis for low-frequency wide bandwidth shielding (L and S radar bands). The synthesized materials were characterized using XRD, SEM, FTIR and microwave magneto dielectric spectroscopy. The dimension of these solvothermally synthesized pristine particles and hybrids lies within 30-58 nm. Microwave magneto-dielectric spectroscopy was performed in the low-frequency region in the 1 MHz-3 GHz spectrum. The as-synthesized pristine nanoparticles and hybrids were found to be highly absorbing for microwaves throughout the L and S radar bands (< -10 dB from 1 MHz to 3 GHz). This excellent microwave absorbing property induced by graphene sheet coupling shows application of these materials with absorption bandwidth which is tailored such that these could be used for low frequency. Previously, these were used for high frequency absorptions (typically > 4 GHz) with limited selective bandwidth. PMID:27270944

  16. Influence of Reduced Graphene Oxide on Effective Absorption Bandwidth Shift of Hybrid Absorbers

    PubMed Central

    Ameer, Shahid; Gul, Iftikhar Hussain

    2016-01-01

    The magnetic nanoparticle composite NiFe2O4 has traditionally been studied for high-frequency microwave absorption with marginal performance towards low-frequency radar bands (particularly L and S bands). Here, NiFe2O4 nanoparticles and nanohybrids using large-diameter graphene oxide (GO) sheets are prepared via solvothermal synthesis for low-frequency wide bandwidth shielding (L and S radar bands). The synthesized materials were characterized using XRD, SEM, FTIR and microwave magneto dielectric spectroscopy. The dimension of these solvothermally synthesized pristine particles and hybrids lies within 30–58 nm. Microwave magneto-dielectric spectroscopy was performed in the low-frequency region in the 1 MHz-3 GHz spectrum. The as-synthesized pristine nanoparticles and hybrids were found to be highly absorbing for microwaves throughout the L and S radar bands (< −10 dB from 1 MHz to 3 GHz). This excellent microwave absorbing property induced by graphene sheet coupling shows application of these materials with absorption bandwidth which is tailored such that these could be used for low frequency. Previously, these were used for high frequency absorptions (typically > 4 GHz) with limited selective bandwidth. PMID:27270944

  17. Ultra-wide Bandwidth Inter-Chip Interconnects for Heterogeneous Millimeter-Wave and THz Circuits

    NASA Astrophysics Data System (ADS)

    Fay, Patrick; Bernstein, Gary H.; Lu, Tian; Kulick, Jason M.

    2016-09-01

    Heterogeneous chip-to-chip interconnects with low loss and ultra-wide bandwidths have been demonstrated. Coplanar waveguide-based interconnects between GaAs and Si die have been fabricated and characterized and the results compared to expectations from full-wave electromagnetic simulation. Broadband transmission characteristics were obtained, with insertion losses below 0.3 dB at 100 GHz and below 0.8 dB at frequencies up to 220 GHz demonstrated experimentally. The measured return loss exceeded 11.5 dB at all frequencies up to 220 GHz. The interconnects offer low latency, with a measured group delay of 0.69 ps. The measured results are in good agreement with full-wave simulations, indicating that the measured results do not suffer from significant impairments compared to theoretical predictions. The demonstrated interconnects offer an alternative to conventional approaches to millimeter-wave circuit and system integration, by enabling the compact realization of circuits in the microwave, millimeter-wave, sub-millimeter-wave, and THz frequency regimes in heterogeneous device technologies with very low chip-to-chip insertion loss.

  18. Optical delay control of large-spectral-bandwidth laser pulses

    SciTech Connect

    Ignesti, E.; Tognetti, M. V.; Buffa, R.; Cavalieri, S.; Fini, L.; Sali, E.; Eramo, R.

    2009-07-15

    In this Rapid Communication we report an experimental observation of temporal delay control of large-spectral-bandwidth multimode laser pulses by means of electromagnetically induced transparency. We achieved optically controllable retardation of laser pulses with an input spectral bandwidth of 3.3 GHz with limited temporal distortion and excellent values of the delay-bandwidth product. The experimental results compare favorably with a theoretical analysis.

  19. A 5.4-9.2 GHz 19.5 dB Complementary Metal-Oxide-Semiconductor Ultrawide-Band Receiver Front-End Low-Noise Amplifier

    NASA Astrophysics Data System (ADS)

    Azhari, Afreen; Kubota, Shinichi; Toya, Akihiro; Sasaki, Nobuo; Kikkawa, Takamaro

    2011-04-01

    In this work, we present an ultrawide-band (UWB) complementary metal-oxide-semiconductor (CMOS) low-noise amplifier (LNA) for wireless communication in the upper UWB band, that is, from 5.4-9.2 GHz bandwidth with a wide-band 50 Ω input matching network in front of the LNA. A three-stage cascode-topology-based LNA with high-transconductance MOS transistors, was employed to improve the voltage gain up to 23 dB at 7.5 GHz, with 4.5-9.2 GHz 3 dB bandwidth. The maximum output power S21 was 19.5 dB at 7.3 GHz, with 5.4-9.2 GHz 3 dB bandwidth. The input matching circuit was designed with a reduced number of passive elements, resulting in an input reflection coefficient S11 of less than -10 dB from 4.5-9.2 GHz. The noise figure of the LNA was as low as 3.5 dB and the input-referred third-order intercept point (IIP3) was -8 dBm. The LNA has output reflection coefficient S22 of less than -10 dB from 5-7 GHz and a good reverse isolation, that is, S12 of < -45 dB in the entire UWB, due to a cascode topology. The LNA was fabricated using 180 nm CMOS technology, which consumes 56 mW power at 1.8 V power supply. In this paper, we also demonstrate a wireless communication of 7 GHz Gaussian monocycle pulse (GMP) by horn antennas and the LNA from 20 cm transmission distance.

  20. Comparative study on the performance of power and bandwidth efficient modulations in LMSS under fading and interference

    NASA Technical Reports Server (NTRS)

    Liu, Jian; Kim, Junghwan; Kwatra, S. C.; Stevens, Grady H.

    1991-01-01

    Aspects of error performance of various power and bandwidth efficient modulations for the land mobile satellite systems (LMSS) were investigated under multipath fading and interferences by using Monte-Carlo simulation. A differential detection for 16QAM (quadrature amplitude modulation) was proposed to cope with Ricean fading and Doppler shift. Computer simulation results show that the performance of 16QAM with differential detection is as good as that of 16PSK with coherent detection and 3 dB better than that of 16PSK with differential detection, although it degrades by about 4.5 dB as compared to 16QAM with coherent detection under an additive white Gaussian noise (AWGN) channel. For the nonlinear channels, 16QAM with modified signal constellations is introduced and analyzed. The simulation results show that the modified 16QAM exhibits a gain of 2.5 dB over 16PSK under traveling-wave tube nonlinearity, and about 4 dB gain over 16PSK at the bit error rate of 10 exp -5 under AWGN. Computer simulation results for modified 16 QAM under cochannel interference and adjacent-channel interference are also presented.

  1. 47 CFR 2.202 - Bandwidths.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... emission I. NO MODULATING SIGNAL Continuous wave emission N0N (zero) II. AMPLITUDE MODULATION 1. Signal With Quantized or Digital Information Continuous wave telegraphy Bn=BK, K=5 for fading circuits, K=3... channels) Bn=sum of M for each sideband 2 channels, M=3000, Bandwidth: 6000 Hz=6 kHz 6K00B8E 3....

  2. 47 CFR 2.202 - Bandwidths.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... emission I. NO MODULATING SIGNAL Continuous wave emission N0N (zero) II. AMPLITUDE MODULATION 1. Signal With Quantized or Digital Information Continuous wave telegraphy Bn=BK, K=5 for fading circuits, K=3... channels) Bn=sum of M for each sideband 2 channels, M=3000, Bandwidth: 6000 Hz=6 kHz 6K00B8E 3....

  3. 47 CFR 2.202 - Bandwidths.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... emission I. NO MODULATING SIGNAL Continuous wave emission N0N (zero) II. AMPLITUDE MODULATION 1. Signal With Quantized or Digital Information Continuous wave telegraphy Bn=BK, K=5 for fading circuits, K=3... channels) Bn=sum of M for each sideband 2 channels, M=3000, Bandwidth: 6000 Hz=6 kHz 6K00B8E 3....

  4. 47 CFR 2.202 - Bandwidths.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... emission I. NO MODULATING SIGNAL Continuous wave emission N0N (zero) II. AMPLITUDE MODULATION 1. Signal With Quantized or Digital Information Continuous wave telegraphy Bn=BK, K=5 for fading circuits, K=3... channels) Bn=sum of M for each sideband 2 channels, M=3000, Bandwidth: 6000 Hz=6 kHz 6K00B8E 3....

  5. Ultrahigh bandwidth signal processing

    NASA Astrophysics Data System (ADS)

    Oxenløwe, Leif Katsuo

    2016-04-01

    Optical time lenses have proven to be very versatile for advanced optical signal processing. Based on a controlled interplay between dispersion and phase-modulation by e.g. four-wave mixing, the processing is phase-preserving, and hence useful for all types of data signals including coherent multi-level modulation formats. This has enabled processing of phase-modulated spectrally efficient data signals, such as orthogonal frequency division multiplexed (OFDM) signals. In that case, a spectral telescope system was used, using two time lenses with different focal lengths (chirp rates), yielding a spectral magnification of the OFDM signal. Utilising such telescopic arrangements, it has become possible to perform a number of interesting functionalities, which will be described in the presentation. This includes conversion from OFDM to Nyquist WDM, compression of WDM channels to a single Nyquist channel and WDM regeneration. These operations require a broad bandwidth nonlinear platform, and novel photonic integrated nonlinear platforms like aluminum gallium arsenide nano-waveguides used for 1.28 Tbaud optical signal processing will be described.

  6. Improved-Bandwidth Transimpedance Amplifier

    NASA Technical Reports Server (NTRS)

    Chapsky, Jacob

    2009-01-01

    The widest available operational amplifier, with the best voltage and current noise characteristics, is considered for transimpedance amplifier (TIA) applications where wide bandwidth is required to handle fast rising input signals (as for time-of-flight measurement cases). The added amplifier inside the TIA feedback loop can be configured to have slightly lower voltage gain than the bandwidth reduction factor.

  7. Fiber optic 3-component seismometer

    NASA Astrophysics Data System (ADS)

    Han, Jing; Zhang, Wentao; Jiang, Dongshan; Wang, Zhaogang; Li, Fang

    2014-06-01

    An all-metal 3-component optical fiber seismometer was proposed and experimentally demonstrated. The theoretical analysis was given based on the electro-mechanical theory. Calibration results showed that the axis sensitivity was about 41 dB (re: 0 dB=1 rad/g) with a fluctuation ±2 dB in the frequency bandwidth of 5 Hz-400 Hz. A transverse sensitivity of about -40 dB was achieved. The fluctuation of the acceleration sensitivity for the three accelerometers in the seismometer was within ±2.5 dB. The minimum phase demodulation detection accuracy of the phase-generated carrier (PGC) was 10-5 rad/√Hz, and the minimum detectable acceleration was calculated to be 90 ng/√Hz.

  8. Kernel bandwidth estimation for nonparametric modeling.

    PubMed

    Bors, Adrian G; Nasios, Nikolaos

    2009-12-01

    Kernel density estimation is a nonparametric procedure for probability density modeling, which has found several applications in various fields. The smoothness and modeling ability of the functional approximation are controlled by the kernel bandwidth. In this paper, we describe a Bayesian estimation method for finding the bandwidth from a given data set. The proposed bandwidth estimation method is applied in three different computational-intelligence methods that rely on kernel density estimation: 1) scale space; 2) mean shift; and 3) quantum clustering. The third method is a novel approach that relies on the principles of quantum mechanics. This method is based on the analogy between data samples and quantum particles and uses the SchrOdinger potential as a cost function. The proposed methodology is used for blind-source separation of modulated signals and for terrain segmentation based on topography information.

  9. Enhancing bandwidth of Josephson parametric amplifiers with impedance engineering

    NASA Astrophysics Data System (ADS)

    Roy, Tanay; A M, Vadiraj; Kundu, Suman; Patankar, Meghan; Vijayaraghavan, Rajamani

    2015-03-01

    Josephson parametric amplifiers (JPAs) are a crucial component of superconducting quantum information processing systems since they enable fast, high-fidelity measurement of qubits. However, JPAs based on a single SQUID oscillator suffer from two major drawbacks - narrow bandwidth and gain saturation at low signal powers, and are typically suited to single qubit experiments only. With the rapid development of multi-qubit systems, there is a practical need to develop an amplifier with larger bandwidth and signal handling capacity, while maintaining gain and noise performance. We will describe a new method to enhance the bandwidth by introducing a frequency dependent shunting impedance for the JPA. To prevent gain saturation, we also replace the single SQUID with a SQUID array. With an appropriate choice of device parameters, numerical calculations indicate the possibility of obtaining 20 dB gain with 700 MHz of bandwidth and near quantum limited noise performance. We will present experimental results demonstrating bandwidth enhancement and discuss strategies for optimizing overall amplifier performance.

  10. Noise and Bandwidth Measurements of Diffusion-Cooled Nb Hot-Electron Bolometer Mixers at Frequencies Above the Superconductive Energy Gap

    NASA Technical Reports Server (NTRS)

    Wyss, R. A.; Karasik, B. S.; McGrath, W. R.; Bumble, B.; LeDuc, H.

    1999-01-01

    Diffusion-cooled Nb hot-electron bolometer (HEB) mixers have the potential to simultaneously achieve high intermediate frequency (IF) bandwidths and low mixer noise temperatures for operation at THz frequencies (above the superconductive gap energy). We have measured the IF signal bandwidth at 630 GHz of Nb devices with lengths L = 0.3, 0.2, and 0.1 micrometer in a quasioptical mixer configuration employing twin-slot antennas. The 3-dB EF bandwidth increased from 1.2 GHz for the 0.3 gm long device to 9.2 GHz for the 0.1 gm long device. These results demonstrate the expected 1/L squared dependence of the IF bandwidth at submillimeter wave frequencies for the first time, as well as the largest EF bandwidth obtained to date. For the 0.1 gm device, which had the largest bandwidth, the double sideband (DSB) noise temperature of the receiver was 320-470 K at 630 GHz with an absorbed LO power of 35 nW, estimated using the isothermal method. A version of this mixer with the antenna length scaled for operation at 2.5 THz has also been tested. A DSB receiver noise temperature of 1800 plus or minus 100 K was achieved, which is about 1,000 K lower than our previously reported results. These results demonstrate that large EF bandwidth and low-noise operation of a diffusion-cooled HEB mixer is possible at THz frequencies with the same device geometry.

  11. Bandwidth, Broadband, and Planning for Public Access

    ERIC Educational Resources Information Center

    Blowers, Helene

    2012-01-01

    Broadband and bandwidth allocation is an essential technology planning activity that libraries should address on a continual basis. There are five key factors that will impact your network's performance: 1. infrastructure, 2. network load, 3. workstation performance, 4. prioritization of services, and 5. network management. The author thinks it's…

  12. Feasibility studies of optical processing of image bandwidth compression schemes

    NASA Astrophysics Data System (ADS)

    Hunt, B. R.; Strickland, R. N.; Schowengerdt, R. A.

    1983-05-01

    This research focuses on these three areas: (1) formulation of alternative architectural concepts for image bandwidth compression, i.e., the formulation of components and schematic diagrams which differ from conventional digital bandwidth compression schemes by being implemented by various optical computation methods; (2) simulation of optical processing concepts for image bandwidth compression, so as to gain insight into typical performance parameters and elements of system performance sensitivity; and (3) maturation of optical processing for image bandwidth compression until the overall state of optical methods in image compression becomes equal to that of digital image compression.

  13. A mutation in the alpha 3 domain of Db that abrogates CD8 binding does not affect presentation of an immunodominant H-Y peptide.

    PubMed Central

    Dutz, J P; Teh, S J; Killeen, N; Teh, H S

    1995-01-01

    The peptidic nature of the male (H-Y) antigen, a model minor histocompatibility antigen in H-2b mice, has recently been demonstrated. In this study we show that the H-Y peptide, which is recognized by PM-1, a Db-restricted cytotoxic T-lymphocyte (CTL) clone, is absent in male H-2d spleen cells but present in male H-2d spleen cells that also express a transgenic Db molecule under its endogenous promoter. This result indicates that both the H-Y and the Db gene products are essential and sufficient for production of the Db-restricted H-Y peptide. By comparing the ability of the PM-1 clone and bulk CTL generated in a secondary mixed lymphocyte culture to recognize H-Y peptidic material eluted from affinity-purified Db molecules and separated by reversed-phase high-performance liquid chromatography (HPLC), we provide evidence that there is an immunodominant H-Y epitope that is presented by the Db molecule. Furthermore, the presentation of this epitope is not affected by a mutation in the alpha 3 domain of Db (asp227 to lys227), which abrogates CD8 binding, since similar amounts of H-Y peptide were eluted from affinity-purified wild-type or mutant Db molecules. However, the generation of the H-Y epitope is dependent on the presence of beta 2-microglobulin, since it is absent in male H-2b mice that lack a functional beta 2-microglobulin gene. The implications of these findings on T-cell development are discussed. PMID:7543449

  14. Adaptive low-bandwidth tracking of Galileo and Pioneer 10 carriers

    NASA Technical Reports Server (NTRS)

    Watola, D. A.

    1992-01-01

    In the Deep Space Network, tracking of residual carrier phase typically occurs with a fixed-bandwidth phase-locked loop using a bandwidth sufficiently wide to prevent loss of lock under worst-case conditions of signal dynamics, received signal phase noise, and receiver phase noise. Much of the time, however, such a high bandwidth is not required and may inflict unnecessarily heavy penalties on loop signal-to-noise ratios. This article describes a technique for improving tracking performance by permitting initial tracking at narrow bandwidths and gradually widening the loop as needed. The cost is a requirement for signal buffering, which is relatively inexpensive for low data rate applications. Results based on off-line processing of recorded carrier data from Galileo and Pioneer 10 are presented, and show potential 10-16 dB gains in loop SNR over worst-case fixed-bandwidth tracking.

  15. High-power test of the new 3-dB power splitter for the PAL XFEL S-band LINAC RF system

    NASA Astrophysics Data System (ADS)

    Joo, Youngdo; Park, Yongjung; Heo, Hoon; Hu, Jinyul; Park, Sung-Soo; Kim, Sang-Hee; Hwang, Woonha; Moon, Gun-Young; Lee, Sosung; Lee, Heung-Soo; Noh, Sungju; Oh, Kyoungmin

    2014-04-01

    The 3-dB power splitter to be used in the Pohang Accelerator Laboratory X-ay Free-electron Laser (PAL XFEL), which have been under construction since 2011, must operate at a peak power of 400 MW and a repetition rate of 120 Hz. For these operational conditions of the PAL XFEL, the old 3-dB power splitter that was originally designed to be used in the PLS LINAC will most suffer from RF breakdown. Therefore, for the new 3-dB power splitter, the original design has been modified to reduce the field gradient and the surface current. The new 3-dB power splitter is designed by using a finite-difference time-domain (FDTD) simulation. We have fabricated a prototype, and the result of a high-power test indicates that the RF performance of the new 3-dB power splitter satisfies the specifications of the PAL XFEL S-band LINAC RF system.

  16. Network Bandwidth Utilization Forecast Model on High Bandwidth Network

    SciTech Connect

    Yoo, Wucherl; Sim, Alex

    2014-07-07

    With the increasing number of geographically distributed scientific collaborations and the scale of the data size growth, it has become more challenging for users to achieve the best possible network performance on a shared network. We have developed a forecast model to predict expected bandwidth utilization for high-bandwidth wide area network. The forecast model can improve the efficiency of resource utilization and scheduling data movements on high-bandwidth network to accommodate ever increasing data volume for large-scale scientific data applications. Univariate model is developed with STL and ARIMA on SNMP path utilization data. Compared with traditional approach such as Box-Jenkins methodology, our forecast model reduces computation time by 83.2percent. It also shows resilience against abrupt network usage change. The accuracy of the forecast model is within the standard deviation of the monitored measurements.

  17. Steel Industry Energy Bandwidth Study

    SciTech Connect

    none,

    2004-10-01

    ITP conducted a study on energy use and potential savings, or "bandwidth" study, in major steelmaking processes. Intended to provide a realistic estimate of the potential amount of energy that can be saved in an industrial process, the "bandwidth" refers to the difference between the amount of energy that would be consumed in a process using commercially available technology versus the minimum amount of energy needed to achieve those same results based on the 2nd law of thermodynamics. The Steel Industry Energy Bandwidth Study (PDF 133 KB) also estimates steel industry energy use in the year 2010, and uses that value as a basis for comparison against the minimum requirements. This energy savings opportunity for 2010 will aid focus on longer term R&D.

  18. Generation of 15-nJ bunched noise-like pulses with 93-nm bandwidth in an erbium-doped fiber ring laser

    NASA Astrophysics Data System (ADS)

    Zhao, L. M.; Tang, D. Y.

    2006-06-01

    We report on the generation of high power superbroad spectrum bunched noise-like pulses from a passively mode-locked erbium-doped fiber ring laser without using the stretched-pulse technique. The maximum 3-dB spectral bandwidth of the noise-like pulses is about 93 nm with an energy of about 15 nJ. We further show numerically that the superbroad spectrum of the pulses is caused by the transform-limited feature of the pulses together with the Raman self-frequency shift effect.

  19. Schottky Heterodyne Receivers With Full Waveguide Bandwidth

    NASA Technical Reports Server (NTRS)

    Hesler, Jeffrey; Crowe, Thomas

    2011-01-01

    Compact THz receivers with broad bandwidth and low noise have been developed for the frequency range from 100 GHz to 1 THz. These receivers meet the requirements for high-resolution spectroscopic studies of planetary atmospheres (including the Earth s) from spacecraft, as well as airborne and balloon platforms. The ongoing research is significant not only for the development of Schottky mixers, but also for the creation of a receiver system, including the LO chain. The new receivers meet the goals of high sensitivity, compact size, low total power requirement, and operation across complete waveguide bands. The exceptional performance makes these receivers ideal for the broader range of scientific and commercial applications. These include the extension of sophisticated test and measurement equipment to 1 THz and the development of low-cost imaging systems for security applications and industrial process monitoring. As a particular example, a WR-1.9SHM (400-600 GHz) has been developed (see Figure 1), with state-of-the-art noise temperature ranging from 1,000-1,800 K (DSB) over the full waveguide band. Also, a Vector Network Analyzer extender has been developed (see Figure 2) for the WR1.5 waveguide band (500 750 GHz) with 100-dB dynamic range.

  20. On the Use of 3dB Qualification Margin for Structural Parts on Expendable Launch Vehicles

    NASA Technical Reports Server (NTRS)

    Yunis, Isam

    2007-01-01

    The standard random vibration qualification test used for Expendable Launch Vehicle components is Maximum Predicted Environment (MPE) + 6dB for a duration of 4 times the service life of the part. This can be a severe qualification test for these fatigue-sensitive structures. This paper uses flight data from several launch vehicles to establish that reducing the qualification approach to MPE+3dB for the duration of the peak environment (1x life) is valid for fatigue-sensitive structural components. Items that can be classified as fatigue-sensitive are probes, ducts, tubing, bellows, hoses, and any non-functional structure. Non-functional structure may be flight critical or carry fluid, but it cannot include any moving parts or electronics. This reduced qualification approach does not include primary or secondary structure which would be exclusively designed by peak loads, either transient or quasi-static, that are so large and of so few cycles as to make fatigue a moot point.

  1. Mining Industry Energy Bandwidth Study

    SciTech Connect

    none,

    2007-07-01

    The Industrial Technologies Program (ITP) relies on analytical studies to identify large energy reduction opportunities in energy-intensive industries and uses these results to guide its R&D portfolio. The energy bandwidth illustrates the total energy-saving opportunity that exists in the industry if the current processes are improved by implementing more energy-efficient practices and by using advanced technologies. This bandwidth analysis report was conducted to assist the ITP Mining R&D program in identifying energy-saving opportunities in coal, metals, and mineral mining. These opportunities were analyzed in key mining processes of blasting, dewatering, drilling, digging, ventilation, materials handling, crushing, grinding, and separations.

  2. High energy pulses generation with giant spectrum bandwidth and submegahertz repetition rate from a passively mode-locked Yb-doped fiber laser in all normal dispersion cavity

    NASA Astrophysics Data System (ADS)

    Lin, J.-H.; Wang, D.; Lin, K.-H.

    2011-01-01

    Robust passively mode-locked pulse generation with low pulse repetition rate and giant spectrum bandwidth in an all-fiber, all-normal-dispersion ytterbium-doped fiber laser has been experimentally demonstrated using nonlinear polarization evolution technique. The highest pulse energy over 20 nJ with spectrum bandwidth over 50 nm can be experimentally obtained at 175 mW pump power. The mode-locked pulses reveal broadened 3-dB pulsewidth about several nanosecond and widened pedestal in time trace that is resulted from enormous dispersion in laser cavity and gain dynamics. At certain mode-locking state, a spectrum gap around 1056 nm are observed between the three and four energy levels of Yb-doped fiber laser. By properly rotating the polarization controller, the gap can be eliminated due to four-wave mixing to produce more flattened spectrum output.

  3. Squeezed light at 1550 nm with a quantum noise reduction of 12.3 dB.

    PubMed

    Mehmet, Moritz; Ast, Stefan; Eberle, Tobias; Steinlechner, Sebastian; Vahlbruch, Henning; Schnabel, Roman

    2011-12-01

    Continuous-wave squeezed states of light at the wavelength of 1550 nm have recently been demonstrated, but so far the obtained factors of noise suppression still lag behind today's best squeezing values demonstrated at 1064 nm. Here we report on the realization of a half-monolithic nonlinear resonator based on periodically-poled potassium titanyl phosphate which enabled the direct detection of up to 12.3 dB of squeezing at 5 MHz. Squeezing was observed down to a frequency of 2 kHz which is well within the detection band of gravitational wave interferometers. Our results suggest that a long-term stable 1550 nm squeezed light source can be realized with strong squeezing covering the entire detection band of a 3rd generation gravitational-wave detector such as the Einstein Telescope.

  4. Developing Strategies for Affordable Bandwidth.

    ERIC Educational Resources Information Center

    Educause Quarterly, 2000

    2000-01-01

    Written by Educause's Net@EDU Broadband Pricing Working Group, this article discusses what institutions of higher education can do to develop good partnerships with broadband vendors in order to negotiate affordable pricing for increased bandwidth. Describes problems with the marketplace, examples from a few universities, and points to remember…

  5. Piezo-adapted 3-isopropylmalate dehydrogenase of the obligate piezophile Shewanella benthica DB21MT-2 isolated from the 11,000-m depth of the Mariana Trench.

    PubMed

    Kasahara, Ryota; Sato, Takako; Tamegai, Hideyuki; Kato, Chiaki

    2009-11-01

    3-isopropylmalate dehydrogenase (IPMDH)-encoding leuB genes were obtained from the obligate piezophile Shewanella benthica DB21MT-2 and non-piezophile Shewanella oneidensis MR-1. The genes were expressed in Escherichia coli and the proteins were purified using His-tag. The estimated kinetic parameters of these enzymes indicated that IPMDH of S. benthica DB21MT-2 is more tolerant of high pressure than that of S. oneidensis MR-1. Thus such an adaptation is one of the mechanisms bacteria utilize for survival at high pressures. PMID:19897891

  6. Hop and Acacia Phytochemicals Decreased Lipotoxicity in 3T3-L1 Adipocytes, db/db Mice, and Individuals with Metabolic Syndrome

    PubMed Central

    Minich, Deanna M.; Lerman, Robert H.; Darland, Gary; Babish, John G.; Pacioretty, Linda M.; Bland, Jeffrey S.; Tripp, Matthew L.

    2010-01-01

    The plant-based compounds rho-iso-alpha acids (RIAA) from Humulus lupulus (hops) and proanthocyanidins (PAC) from Acacia nilotica have been shown to modulate insulin signaling in vitro. We investigated their effects on triglyceride (TG) deposition in 3T3-L1 adipocytes, glucose and insulin in obese mouse models, and metabolic syndrome markers in adults with metabolic syndrome. The combination of RIAA and PAC synergistically increased TG content and adiponectin secretion in 3T3-L1 adipocytes under hyperinsulinemic conditions and reduced glucose or insulin in obese mice. In a clinical trial, tablets containing 100 mg RIAA and 500 mg PAC or placebo were administered to metabolic syndrome subjects (3 tablets/day, n = 35; 6 tablets/day, n = 34; or placebo, n = 35) for 12 weeks. Compared to placebo, subjects taking 3 tablets daily showed greater reductions in TG, TG : HDL, fasting insulin, and HOMA scores. The combination of RIAA : PAC at 1 : 5 (wt : wt) favorably modulates dysregulated lipids in insulin resistance and metabolic syndrome. PMID:20721358

  7. Phase locking and bandwidth in a gyrotron oscillator

    NASA Astrophysics Data System (ADS)

    Latham, P. E.; Granatstein, V. L.; Carmel, Y.

    1993-06-01

    For imaging radar and for satellite and space communication (e.g. NASA's deep space network), it is important that the bandwidth be as large as possible. Here we derive a formalism for computing the phase locking bandwidth that can be achieved in a gyrotron oscillator while varying the beam voltage. As an example, a second harmonic TE02/03 gyrotron is considered. For this device, the effective bandwidth can be increased by a factor of about 3 compared with the fixed voltage case by allowing the beam voltage to change together with the input locking signal.

  8. Phase locking and bandwidth in a gyrotron oscillator

    NASA Technical Reports Server (NTRS)

    Latham, P. E.; Granatstein, V. L.; Carmel, Y.

    1993-01-01

    For imaging radar and for satellite and space communication (e.g. NASA's deep space network), it is important that the bandwidth be as large as possible. Here we derive a formalism for computing the phase locking bandwidth that can be achieved in a gyrotron oscillator while varying the beam voltage. As an example, a second harmonic TE02/03 gyrotron is considered. For this device, the effective bandwidth can be increased by a factor of about 3 compared with the fixed voltage case by allowing the beam voltage to change together with the input locking signal.

  9. Synthesis and Structure of [DB24C8)Na][Cd(SCN)3. Formation of a novel linear Cd...Cd...Cd chain with a mer-CdN3S3 coordination confirmation and new coiled [(DB24C8)Na]+ cation.

    PubMed

    Zhang, H; Wang, X; Zelmon, D E; Teo, B K

    2001-03-26

    We report herein a novel coordination solid, [(DB24C8)Na][Cd(SCN)3] (6) (DB24C8 denotes dibenzo-24-crown-8), which exhibits a new type of [Cd(SCN)3-]infinity chain with two unusual stereochemical characteristics: (1) a mer-CdN3S3 coordination and (2) a linear Cd chain with a Cd...Cd...Cd angle of 180 degrees. In addition, the [(DB24C8)Na]+ monocation adopts a new structural type-a coiled structure-for the combination of crown ether DB24C8 and alkali metal Na+. The title compound crystallizes in a monoclinic unit cell of C2/c space group symmetry with lattice parameters a = 16.110(8) A, b = 20.380(5) A, c = 11.01(1) A, beta = 119.87(3) degrees, and Z = 4. The arrangement of the [Cd(SCN)3-](infinity) chains in the crystal lattice in the title compound is approximately hexagonal, creating triangular channels which are filled with [(DB24C8)Na]+ monocations. It was previously reasoned by us that the coiled [(DB24C8)Na]+ monocation, which lacks inversion or mirror symmetries, should enhance the tendency for the formation of the noncentrosymmetric space group of the title crystal, making it a potential second-order nonlinear optical crystal. Interestingly, however, the title compound crystallizes in a centrosymmetric space group (C2/c) and gives rise to no second harmonic generation (SHG). Previously known [Cd(SCN)3-](infinity) chains adopt fac-CdN3S3 coordination and a zigzag Cd chain configuration with a Cd...Cd...Cd angle of 165 degrees. The zigzag chains can align in either parallel or antiparallel fashion, resulting in efficient or no SHG effects, respectively. The linear Cd.Cd.Cd chain configuration observed in the title compound, on the other hand, makes it indistinguishable between parallel and antiparallel alignments. It is concluded that, to ensure the formation of noncentrosymmetric space groups, it is necessary to employ optically pure chiral cations as spacers and/or controllers. Furthermore, to enhance the nonlinear optical responses, [Cd(SCN)3-]infinity

  10. Identification of an H2-Kb or H2-Db restricted and glypican-3-derived cytotoxic T-lymphocyte epitope peptide

    PubMed Central

    IWAMA, TATSUAKI; HORIE, KAZUTAKA; YOSHIKAWA, TOSHIAKI; NOBUOKA, DAISUKE; SHIMOMURA, MANAMI; SAWADA, YU; NAKATSURA, TETSUYA

    2013-01-01

    Glypican-3 (GPC3) is overexpressed in human hepatocellular carcinoma (HCC) but not expressed in normal tissues except for placenta and fetal liver and therefore is an ideal target for cancer immunotherapy. In this study, we identified an H2-Kb or H2-Db restricted and murine GPC3 (mGPC3)-derived cytotoxic T-lymphocyte (CTL) epitope peptide in C57BL/6 (B6) mice, which can be used in the design of preclinical studies of various therapies with GPC3-target immunotherapy in vivo. First, 11 types of 9- to 10-mer peptides predicted to bind with H2-Kb or H2-Db were selected from the mGPC3 amino acid sequence based on the binding score as calculated by the BIMAS software. We evaluated the peptide-binding affinity and confirmed that all peptides were able to bind to H2-Kb or H2-Db by in vitro cellular binding assay. Subsequently, a mixed peptide vaccine and single peptide vaccine were given to B6 mice to evaluate immunogenic potential of the 11 selected peptides. Using the splenocytes from peptide-vaccinated mice, interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) assays showed that mGPC3-1127–136 (AMFKNNYPSL) peptide was the most efficient for inducing CTLs among the 11 peptides. Next, we demonstrated that the mGPC3-1 peptide-specific CTL line could recognize mGPC3-expressing cancer cells, suggesting that mGPC3-1 peptide was an endogenously presented peptide. In conclusion, we identified mGPC3-1 as an H2-Kb or H2-Db restricted, mGPC3-derived CTL epitope peptide. PMID:23354275

  11. Design of a demonstration experiment on the wide-bandwidth high-power dielectric Cherenkov maser amplifier

    SciTech Connect

    Harin, V.; Melnikov, G.; Shlapapkovskii, A.

    1995-12-31

    Bandwidth dependences on the parameters of an electron beam and dielectric-fined waveguide have been calculated from the system dispersion relation, and the optimal set of parameters yielding large value of the bandwidth has been chosen. One-dimensional nonlinear simulations have been carried out. The output power of 60 MW at the peak gain of 27 dB is planned to be achieved. The wide-bandwidth input coupler has been constructed, and the results of microwave transmission measurements through the no-beam system are presented.

  12. Demonstration of an X-Band Multilayer Yagi-Like Microstrip Patch Antenna With High Directivity and Large Bandwidth

    NASA Technical Reports Server (NTRS)

    Nessel, James A.; Zaman, Afroz; Lee, Richard Q.; Lambert, Kevin

    2005-01-01

    The feasibility of obtaining large bandwidth and high directivity from a multilayer Yagi-like microstrip patch antenna at 10 GHz is investigated. A measured 10-dB bandwidth of approximately 20 percent and directivity of approximately 11 dBi is demonstrated through the implementation of a vertically-stacked structure with three parasitic directors, above the driven patch, and a single reflector underneath the driven patch. Simulated and measured results are compared and show fairly close agreement. This antenna offers the advantages of large bandwidth, high directivity, and symmetrical broadside patterns, and could be applicable to satellite as well as terrestrial communications.

  13. Algorithms and Requirements for Measuring Network Bandwidth

    SciTech Connect

    Jin, Guojun

    2002-12-08

    This report unveils new algorithms for actively measuring (not estimating) available bandwidths with very low intrusion, computing cross traffic, thus estimating the physical bandwidth, provides mathematical proof that the algorithms are accurate, and addresses conditions, requirements, and limitations for new and existing algorithms for measuring network bandwidths. The paper also discusses a number of important terminologies and issues for network bandwidth measurement, and introduces a fundamental parameter -Maximum Burst Size that is critical for implementing algorithms based on multiple packets.

  14. Improving the Bandwidth Selection in Kernel Equating

    ERIC Educational Resources Information Center

    Andersson, Björn; von Davier, Alina A.

    2014-01-01

    We investigate the current bandwidth selection methods in kernel equating and propose a method based on Silverman's rule of thumb for selecting the bandwidth parameters. In kernel equating, the bandwidth parameters have previously been obtained by minimizing a penalty function. This minimization process has been criticized by practitioners…

  15. Increase of the grating coupler bandwidth with a graphene overlay

    SciTech Connect

    Cheng, Zhenzhou; Li, Zhen; Xu, Ke; Tsang, Hon Ki

    2014-03-17

    We present theoretical and experimental results that demonstrate an increase in the grating bandwidth by placing a graphene on the chip. A focusing subwavelength grating with coupling efficiency of −4.3 dB and 1 dB bandwidth of ∼60 nm was demonstrated. After a graphene sheet was transferred onto the chip, the maximum 1 dB bandwidth was increased to ∼72 nm. Experimental results are consistent with the calculated graphene induced waveguide refractive index and dispersion changes, and the bandwidth improvement may be attributed to the reduction of grating dispersion. This study may be of interest for graphene-on-silicon photonic integrated circuit applications.

  16. 47 CFR 101.109 - Bandwidth.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... good engineering practice, except that Type B, damped-wave emission will not be authorized. (c) The... authorized bandwidth 928 to 929 25 kHz 1 5 6 932 to 932.5, 941 to 941.5 12.5 kHz 1 5 6 932.5 to 935, 941.5 to 944 200 kHz 1 952 to 960 200 KHz 1 5 6 1,850 to 1,990 10 MHz 1 2,110 to 2,130 3.5 MHz 2,130 to...

  17. 47 CFR 101.109 - Bandwidth.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... good engineering practice, except that Type B, damped-wave emission will not be authorized. (c) The... authorized bandwidth 928 to 929 25 kHz 1 5 6 932 to 932.5, 941 to 941.5 12.5 kHz 1 5 6 932.5 to 935, 941.5 to 944 200 kHz 1 952 to 960 200 KHz 1 5 6 1,850 to 1,990 10 MHz 1 2,110 to 2,130 3.5 MHz 2,130 to...

  18. DbPTM 3.0: an informative resource for investigating substrate site specificity and functional association of protein post-translational modifications.

    PubMed

    Lu, Cheng-Tsung; Huang, Kai-Yao; Su, Min-Gang; Lee, Tzong-Yi; Bretaña, Neil Arvin; Chang, Wen-Chi; Chen, Yi-Ju; Chen, Yu-Ju; Huang, Hsien-Da

    2013-01-01

    Protein modification is an extremely important post-translational regulation that adjusts the physical and chemical properties, conformation, stability and activity of a protein; thus altering protein function. Due to the high throughput of mass spectrometry (MS)-based methods in identifying site-specific post-translational modifications (PTMs), dbPTM (http://dbPTM.mbc.nctu.edu.tw/) is updated to integrate experimental PTMs obtained from public resources as well as manually curated MS/MS peptides associated with PTMs from research articles. Version 3.0 of dbPTM aims to be an informative resource for investigating the substrate specificity of PTM sites and functional association of PTMs between substrates and their interacting proteins. In order to investigate the substrate specificity for modification sites, a newly developed statistical method has been applied to identify the significant substrate motifs for each type of PTMs containing sufficient experimental data. According to the data statistics in dbPTM, >60% of PTM sites are located in the functional domains of proteins. It is known that most PTMs can create binding sites for specific protein-interaction domains that work together for cellular function. Thus, this update integrates protein-protein interaction and domain-domain interaction to determine the functional association of PTM sites located in protein-interacting domains. Additionally, the information of structural topologies on transmembrane (TM) proteins is integrated in dbPTM in order to delineate the structural correlation between the reported PTM sites and TM topologies. To facilitate the investigation of PTMs on TM proteins, the PTM substrate sites and the structural topology are graphically represented. Also, literature information related to PTMs, orthologous conservations and substrate motifs of PTMs are also provided in the resource. Finally, this version features an improved web interface to facilitate convenient access to the resource.

  19. Quantitative mass spectrometry of DENV-2 RNA-interacting proteins reveals that the DEAD-box RNA helicase DDX6 binds the DB1 and DB2 3' UTR structures.

    PubMed

    Ward, Alex Michael; Bidet, Katell; Yinglin, Ang; Ler, Siok Ghee; Hogue, Kelly; Blackstock, Walter; Gunaratne, Jayantha; Garcia-Blanco, Mariano A

    2011-01-01

    Dengue virus (DENV) is a rapidly re-emerging flavivirus that causes dengue fever (DF), dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS), diseases for which there are no available therapies or vaccines.  The DENV-2 positive-strand RNA genome contains 5' and 3' untranslated regions (UTRs) that have been shown to form secondary structures required for virus replication and interaction with host cell proteins.  In order to comprehensively identify host cell factors that bind the DENV-2 UTRs, we performed RNA chromatography, using the DENV-2 5' and 3' UTRs as "bait", combined with quantitative mass spectrometry.  We identified several proteins, including DDX6, G3BP1, G3BP2, Caprin1, and USP10, implicated in P body (PB) and stress granule (SG) function, and not previously known to bind DENV RNAs.  Indirect immunofluorescence microscopy showed these proteins to colocalize with the DENV replication complex.  Moreover, DDX6 knockdown resulted in reduced amounts of infectious particles and viral RNA in tissue culture supernatants following DENV infection. DDX6 interacted with DENV RNA in vivo during infection and in vitro this interaction was mediated by the DB1 and DB2 structures in the 3' UTR, possibly by formation of a pseudoknot structure.  Additional experiments demonstrate that, in contrast to DDX6, the SG proteins G3BP1, G3BP2, Caprin1 and USP10 bind to the variable region (VR) in the 3' UTR.  These results suggest that the DENV-2 3' UTR is a site for assembly of PB and SG proteins and, for DDX6, assembly on the 3' UTR is required for DENV replication.

  20. 18F9 (4-(3,6-bis (ethoxycarbonyl)-4,5,6,7-tetrahydrothieno (2,3-c) pyridin-2-ylamino)-4-oxobutanoic acid) enhances insulin-mediated glucose uptake in vitro and exhibits antidiabetic activity in vivo in db/db mice.

    PubMed

    Anandharajan, Rathinasabapathy; Sayyed, Sufyan G; Doshi, Lalit S; Dixit, Pooja; Chandak, Prakash G; Dixit, Amol V; Brahma, Manoja K; Deshmukh, Nitin J; Gupte, Ravindra; Damre, Anagha; Suthar, Jaspreet; Padigaru, Muralidhara; Sharma, Somesh D; Nemmani, Kumar V S

    2009-10-01

    Insulin resistance is central to the pathogenesis of type 2 diabetes mellitus. Previous studies have demonstrated that compounds that cause adipogenesis and improve glucose uptake in 3T3-L1 cells are potential insulin sensitizers. Therefore, we evaluated one such compound, 18F9, for (1) adipogenesis in human subcutaneous preadipocyte (SQ) cells, (2) glucose uptake in human skeletal muscle myotubes and SQ cells, and (3) antidiabetic activity in db/db mice. We also investigated its effect on ex vivo glucose uptake in soleus muscle isolated from continuously treated db/db mice. Gene expression profiling in soleus muscle and epididymal fat of db/db mice was performed to understand its effect on glucose metabolism, lipid metabolism, and thermogenesis. 18F9 enhanced adipogenesis in SQ cells and increased glucose uptake in SQ and human skeletal muscle myotubes cells. In db/db mice, 18F9 exhibited dose-dependent reduction in plasma glucose and insulin level. Interestingly, 18F9 was as efficacious as rosiglitazone but did not cause body weight gain and hepatic adverse effects. In addition, 18F9 demonstrated no change in plasma volume in Wistar rats. Furthermore, it enhanced ex vivo glucose uptake in soleus muscles in these mice, which substantiates our in vitro findings. Human peroxisome proliferator activated receptor-gamma transactivation assay revealed a weak peroxisome proliferator activated receptor-gamma transactivation potential (44% of rosiglitazone at 10 mumol/L) of 18F9. Gene expression profiling indicated that 18F9 increased insulin sensitivity mainly through a phosphoinositide 3-kinase-dependent mechanism. 18F9 also up-regulated genes involved in lipid transport and synthesis at par with rosiglitazone. Unlike rosiglitazone, 18F9 elevated the expression of Pdk4. In addition, 18F9 elevated the expression of glycogen synthase and adiponectin significantly higher than rosiglitazone. Taken together, these observations suggest that 18F9 is a safer and potent insulin

  1. Low Bandwidth Techniques for Remote Observing

    NASA Astrophysics Data System (ADS)

    Percival, Jeffrey W.

    1994-12-01

    Remote Observing is an ill-defined concept that means different things to different people. For some, it means automated observing. To others, it means simple eavesdropping during observations. Some people even define it to be unachievable, independent of bandwidth or other resources, until the smell of a burning resistor can be sent over a wire. In designing the WIYN 3.5m Telescope Control System, we have decided to avoid defining Remote Observing, and have instead simply set about to chip away at the problem by designing a network-transparent command and control system, a spacecraft-style platform-independent telemetry system, and an innovative method of image compression that lends itself to the progressive transmission of large digital images over low-bandwidth communications links. We found that our users were quite happy with the capabilities of the system. Engineers found they could measure plant response and tune servo loops from half a continent away. Control System designers could monitor operations without disturbing the use of the telescope by on-site personnel. Large images could be sent from the observatory for quick-look analysis or target acquisition in a way that provided useful images in a short time, with an observatory bandwidth requirement that is independent of the number of recipients of the image. The WIYN Telescope will begin science operations in 1995, and time will tell which of these features turn out to be popular with the observers. Rather than remove the astronomer from the dome, they may promote more collaborative observing, provide for more effective observations of targets of opportunity, or allow easy and effective access for students of all types to address important educational objectives of home institutions.

  2. Gallium arsenide integrated circuits for professional broadband applications up to 3 GHz approximately

    NASA Astrophysics Data System (ADS)

    Weidlich, H.; Pettenpaul, E.; Petz, F. A.

    1983-03-01

    A GaAs-FET-technology for the manufacture of fast GaAs broadband IC's was developed with: local ion implantation for the channel and the contact region; Si3N4 cap for annealing and in process surface protection; gold based metallizations in a modified lift-off technique; and a second Si3N4 layer on top of the metallizations for safe enclosure of the active areas and as dielectric for metal insulator metal coupling capacitors. The gains with this technology approximate those of the silicon planar technology. An antenna amplifier with 20 dB gain from 40 to 1000 MHz and a noise figure of about 4 dB was tested in different modifications with integrated load transistors and with external load inductors. The stages are cascadable without matching, so higher gains are possible. An amplifier for measurement equipment with 2 GHz bandwidth and 16 dB gain was constructed with selected antenna amplifier samples using real load resistors. Monolithic integrated differential amplifier stages show gain factors of up to 35 dB with 22 MHz 3 dB-bandwidth suitable for a 2 stage operational amplifier with dB gain and 14 MHz bandwidth.

  3. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice.

    PubMed

    Seo, Kwon-Il; Choi, Myung-Sook; Jung, Un Ju; Kim, Hye-Jin; Yeo, Jiyoung; Jeon, Seon-Min; Lee, Mi-Kyung

    2008-09-01

    We investigated the effect of curcumin on insulin resistance and glucose homeostasis in male C57BL/KsJ-db/db mice and their age-matched lean non-diabetic db/+ mice. Both db/+ and db/db mice were fed with or without curcumin (0.02%, wt/wt) for 6 wks. Curcumin significantly lowered blood glucose and HbA 1c levels, and it suppressed body weight loss in db/db mice. Curcumin improved homeostasis model assessment of insulin resistance and glucose tolerance, and elevated the plasma insulin level in db/db mice. Hepatic glucokinase activity was significantly higher in the curcumin-supplemented db/db group than in the db/db group, whereas glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities were significantly lower. In db/db mice, curcumin significantly lowered the hepatic activities of fatty acid synthase, beta-oxidation, 3-hydroxy-3-methylglutaryl coenzyme reductase, and acyl-CoA: cholesterol acyltransferase. Curcumin significantly lowered plasma free fatty acid, cholesterol, and triglyceride concentrations and increased the hepatic glycogen and skeletal muscle lipoprotein lipase in db/db mice. Curcumin normalized erythrocyte and hepatic antioxidant enzyme activities (superoxide dismutase, catalase, gluthathione peroxidase) in db/db mice that resulted in a significant reduction in lipid peroxidation. However, curcumin showed no effect on the blood glucose, plasma insulin, and glucose regulating enzyme activities in db/+ mice. These results suggest that curcumin seemed to be a potential glucose-lowering agent and antioxidant in type 2 diabetic db/db mice, but had no affect in non-diabetic db/+ mice.

  4. Using ultra narrow bandwidth to overcome traditional problems with distribution line carrier

    SciTech Connect

    Hunt, P.C.; Hunt, L.R.

    1995-12-31

    It has long been common knowledge among communication engineers that wide bandwidth signals require more energy to overcome noise than do narrow band signals. This is why, during adverse conditions Morse code radio communications can get through when voice can`t. To achieve similar range: A television transmitter (6000 kHz bandwidth) requires 200,000 watts; A music broadcast transmitter (60 kHz bandwidth) requires 2000 watts; A voice only transmitter (3 kHz bandwidth) requires 100 watts. Carry this principle to extremes: An Ultra Narrow Bandwidth (UNB) transmitter (.00001 kHz bandwidth) requires .003 watts. This paper explores the advantages of using Ultra Narrow Bandwidth (UNB) in power line carrier systems. Using an Automatic Meter Reading System as an example, the authors explore how UNB allows (or sometimes requires) a change in system architecture, which creates further advantages.

  5. Memory bandwidth-scalable motion estimation for mobile video coding

    NASA Astrophysics Data System (ADS)

    Hsieh, Jui-Hung; Tai, Wei-Cheng; Chang, Tian-Sheuan

    2011-12-01

    The heavy memory access of motion estimation (ME) execution consumes significant power and could limit ME execution when the available memory bandwidth (BW) is reduced because of access congestion or changes in the dynamics of the power environment of modern mobile devices. In order to adapt to the changing BW while maintaining the rate-distortion (R-D) performance, this article proposes a novel data BW-scalable algorithm for ME with mobile multimedia chips. The available BW is modeled in a R-D sense and allocated to fit the dynamic contents. The simulation result shows 70% BW savings while keeping equivalent R-D performance compared with H.264 reference software for low-motion CIF-sized video. For high-motion sequences, the result shows our algorithm can better use the available BW to save an average bit rate of up to 13% with up to 0.1-dB PSNR increase for similar BW usage.

  6. Bandwidth requirements for fine resolution squinted SAR

    SciTech Connect

    DOERRY,ARMIN W.

    2000-03-01

    The conventional rule-of-thumb for Synthetic Aperture Radar is that an RF bandwidth of c/(2{rho}{sub r}) is required to image a scene at the desired slant-range resolution {rho}{sub r}, and perhaps a little more to account for window functions and sidelobe control. This formulation is based on the notion that the total bandwidth required is the same bandwidth that is required for a single pulse. What is neglected is that efficient processing of an entire synthetic aperture of pulses will often require different frequency content for each of the different pulses that makeup a synthetic aperture. Consequently, the total RF bandwidth required of a Synthetic Aperture Radar may then be substantially wider than the bandwidth of any single pulse. The actual RF bandwidth required depends strongly on flight geometry, owing to the desire for a radar to maintain a constant projection of the Fourier space collection surface onto the {omega}{sub y} axis. Long apertures required for fine azimuth resolution, and severe squint angles with steep depression angles may require total RF bandwidths well beyond the minimum bandwidth required of any single transmitted pulse, perhaps even by a factor of two or more. Accounting for this is crucial to designing efficient versatile high-performance imaging radars. This paper addresses how a data set conducive to efficient processing might increase the total RF bandwidth, and presents examples of how a fixed RF bandwidth might then limit SAR geometries.

  7. Broadband Josephson parametric amplifiers: Beyond the standard gain-bandwidth product

    NASA Astrophysics Data System (ADS)

    Roy, Tanay; Kundu, Suman; Chand, Madhavi; Vadiraj, A. M.; Ranadive, A.; Nehra, N.; Patankar, Meghan P.; Aumentado, J.; Clerk, A. A.; Vijay, R.

    Recent development of multiplexed qubit measurement schemes demand broadband quantum-limited amplifiers to enable high fidelity readout with minimal resources. We present a simple technique to enhance the bandwidth of a resonator based Josephson Parametric Amplifier (JPA) beyond the standard gain-bandwidth product. This is achieved by introducing a positive linear slope in the imaginary component of the input impedance seen by the JPA using a λ / 2 transformer. Our theoretical model predicts an extremely flat gain profile with a bandwidth enhancement proportional to the square root of the amplitude gain. Experimentally, we achieved a nearly flat 20 dB gain profile over a 640 MHz band, with a mean 1-dB compression point of -110 dBm along with nearly quantum-limited noise performance. The results are in excellent agreement with our theoretical model. We will then discuss strategies to further enhance the performance in terms of bandwidth and dynamic range of the JPA. Finally, we will consider the applicability of our technique to different parametric pumping methods and other parametric amplifier designs as well.

  8. Performance of a High-Concentration Erbium-Doped Fiber Amplifier with 100 nm Amplification Bandwidth

    SciTech Connect

    Hajireza, P.; Shahabuddin, N. S.; Abbasi-Zargaleh, S.; Emami, S. D.; Abdul-Rashid, H. A.; Yusoff, Z.

    2010-07-07

    Increasing demand for higher bandwidth has driven the need for higher Wavelength Division Multiplexing (WDM) channels. One of the requirements to achieve this is a broadband amplifier. This paper reports the performance of a broadband, compact, high-concentration and silica-based erbium-doped fiber amplifier. The amplifier optimized to a 2.15 m long erbium-doped fiber with erbium ion concentration of 2000 ppm. The gain spectrum of the amplifier has a measured amplification bandwidth of 100 nm using a 980 nm laser diode with power of 150 mW. This silica-based EDFA shows lower noise figure, higher gain and wider bandwidth in shorter wavelengths compared to Bismuth-based EDFA with higher erbium ion concentration of 3250 ppm at equivalent EDF length. The silica-based EDF shows peak gain at 22 dB and amplification bandwidth between 1520 nm and 1620 nm. The lowest noise figure is 5 dB. The gain is further improved with the implementation of enhanced EDFA configurations.

  9. Miniaturized Dual-Band Bandpass Filter Using Embedded Dual-Mode Resonator with Controllable Bandwidths

    NASA Astrophysics Data System (ADS)

    Zhu, Chuanming; Xu, Jin; Kang, Wei; Hu, Zhenxin; Wu, Wen

    2016-09-01

    In this paper, a miniaturized dual-band bandpass filter (DB-BPF) using embedded dual-mode resonator (DMR) with controllable bandwidths is proposed. Two passbands are generated by two sets of resonators operating at two different frequencies. One set of resonators is utilized not only as the resonant elements that yield the lower passband, but also as the feeding structures with source-load coupling to excite the other to produce the upper passband. Sufficient degrees of freedom are achieved to control the center frequencies and bandwidths of two passbands. Moreover, multiple transmission zeros (TZs) are created to improve the passband selectivity of the filter. The design of the filter has been demonstrated by the measurement. The filter features not only miniaturized circuit sizes, low insertion loss, independently controllable central frequencies, but also controllable bandwidths and TZs.

  10. On the spatial bandwidth of scattered fields

    NASA Astrophysics Data System (ADS)

    Bucci, Ovidio M.; Franceschetti, Giorgio

    1987-12-01

    The concept of spatial bandwidth of scattered electromagnetic fields is introduced. It is shown that the scattered fields are almost space-bandlimited functions. The effective bandwidth W is introduced and evaluated for a very general scattering system, as well as the error made using functions bandlimited to values greater than the effective bandwidth (w greater than W) for representing the scattered field. The effective bandwidth is very simply related to the maximum dimension of the scattering system; the error drops to negligible values for modest increases of w compared to W, in the case of large scatterers. Consequences of these general results are stressed.

  11. C57BL/KsJ-db/db-ApcMin/+ Mice Exhibit an Increased Incidence of Intestinal Neoplasms

    PubMed Central

    Hata, Kazuya; Kubota, Masaya; Shimizu, Masahito; Moriwaki, Hisataka; Kuno, Toshiya; Tanaka, Takuji; Hara, Akira; Hirose, Yoshinobu

    2011-01-01

    The numbers of obese people and diabetic patients are ever increasing. Obesity and diabetes are high-risk conditions for chronic diseases, including certain types of cancer, such as colorectal cancer (CRC). The aim of this study was to develop a novel animal model in order to clarify the pathobiology of CRC development in obese and diabetic patients. We developed an animal model of obesity and colorectal cancer by breeding the C57BL/KsJ-db/db (db/db) mouse, an animal model of obesity and type II diabetes, and the C57BL/6J-ApcMin/+ (Min/+) mouse, a model of familial adenomatous polyposis. At 15 weeks of age, the N9 backcross generation of C57BL/KsJ-db/db-ApcMin/+ (db/db-Min/+) mice developed an increased incidence and multiplicity of adenomas in the intestinal tract when compared to the db/m-Min/+ and m/m-Min/+ mice. Blood biochemical profile showed significant increases in insulin (8.3-fold to 11.7-fold), cholesterol (1.2-fold to 1.7-fold), and triglyceride (1.2-fold to 1.3-fold) in the db/db-Min/+ mice, when compared to those of the db/m-Min/+ and m/m-Min/+ mice. Increases (1.4-fold to 2.6-fold) in RNA levels of insulin-like growth factor (IGF)-1, IRF-1R, and IGF-2 were also observed in the db/db- Min/+ mice. These results suggested that the IGFs, as well as hyperlipidemia and hyperinsulinemia, promoted adenoma formation in the db/db-Min/+ mice. Our results thus suggested that the db/db-Min/+ mice should be invaluable for studies on the pathogenesis of CRC in obese and diabetes patients and the therapy and prevention of CRC in these patients. PMID:22174655

  12. Bandwidth Efficient Wireless Digital Modem Developed

    NASA Technical Reports Server (NTRS)

    Kifle, Muli

    1999-01-01

    NASA Lewis Research Center has developed a digital approach for broadcasting highfidelity audio (nearly compact disk (CD) quality sound) in the commercial frequencymodulated (FM) broadcast band. This digital approach provides a means of achieving high data transmission rates with low hardware complexity--including low mass, size, and power consumption. Lewis has completed the design and prototype development of a bandwidth-efficient digital modem (modulator and demodulator) that uses a spectrally efficient modulation scheme: 16-ary rectangular quadrature amplitude modulation, or 16- ary QAM. The digital implementation is based strictly on inexpensive, commercial off-theshelf digital signal processing (DSP) hardware to perform up and down conversions and pulse shaping. The digital modem transmits data at rates up to 76 kilobits per second (kbps), which is almost 3 times faster than standard 28.8-kbps telephone modems. In addition, the modem offers improved power and spectral performance, flexible operation, and low-cost implementation.

  13. RAID Disk Arrays for High Bandwidth Applications

    NASA Technical Reports Server (NTRS)

    Moren, Bill

    1996-01-01

    High bandwidth applications require large amounts of data transferred to/from storage devices at extremely high data rates. Further, these applications often are 'real time' in which access to the storage device must take place on the schedule of the data source, not the storage. A good example is a satellite downlink - the volume of data is quite large and the data rates quite high (dozens of MB/sec). Further, a telemetry downlink must take place while the satellite is overhead. A storage technology which is ideally suited to these types of applications is redundant arrays of independent discs (RAID). Raid storage technology, while offering differing methodologies for a variety of applications, supports the performance and redundancy required in real-time applications. Of the various RAID levels, RAID-3 is the only one which provides high data transfer rates under all operating conditions, including after a drive failure.

  14. 47 CFR 101.109 - Bandwidth.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Bandwidth. 101.109 Section 101.109 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.109 Bandwidth. Link to an amendment published at 77 FR 54432, Sept....

  15. 47 CFR 101.109 - Bandwidth.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bandwidth. 101.109 Section 101.109 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Technical Standards § 101.109 Bandwidth. (a) Each authorization issued pursuant to these...

  16. Directing Traffic: Managing Internet Bandwidth Fairly

    ERIC Educational Resources Information Center

    Paine, Thomas A.; Griggs, Tyler J.

    2008-01-01

    Educational institutions today face budgetary restraints and scarce resources, complicating the decision of how to allot bandwidth for campus network users. Additionally, campus concerns over peer-to-peer networking (specifically outbound Internet traffic) have increased because of bandwidth and copyright issues. In this article, the authors…

  17. Energy Bandwidth for Petroleum Refining Processes

    SciTech Connect

    none,

    2006-10-01

    The petroleum refining energy bandwidth report analyzes the most energy-intensive unit operations used in U.S. refineries: crude oil distillation, fluid catalytic cracking, catalytic hydrotreating, catalytic reforming, and alkylation. The "bandwidth" provides a snapshot of the energy losses that can potentially be recovered through best practices and technology R&D.

  18. Bandwidth enhancement of dielectric resonator antennas

    NASA Technical Reports Server (NTRS)

    Lee, Richard Q.; Simons, Rainee N.

    1993-01-01

    An experimental investigation of bandwidth enhancement of dielectric resonator antennas (DRA) using parasitic elements is reported. Substantial bandwidth enhancement for the HE(sub 11delta) mode of the stacked geometry and for the HE(sub 13delta) mode of the coplanar collinear geometry was demonstrated. Excellent radiation patterns for the HE(sub 11delta) mode were also recorded.

  19. Comparison of the ionizing radiation fields observed by Liulin-Photo and R3D-B3 spectrum-dosimeters inside and outside Foton-M3 spacecraft

    NASA Astrophysics Data System (ADS)

    Damasso, Mario; Dachev, Tsvetan; Zanini, Alba; Falzetta, Giuseppe; Lambreva, Maya; Rea, Giuseppina; Giardi, Maria Teresa

    Foton-M3 ESA space mission flew in Low Earth Orbit (250÷290 km) from 14 to 26 September 2007, carrying more than 40 experiments related to different scientific disciplines. During the mission, the dose and particle flux variations inside and outside the capsule have been monitored in real time by Liulin-Photo e R3D-B3 spectrum-dosimeters respectively, the latter housed in the Biopan-6 facility containing experiments directly exposed to the space environment. Liulin-Photo and R3D-B3 are both composed of a silicon detector (area=2 cm2 ) and they measure the energies deposited by the incident ionizing particles (R3D-B3 measuring also solar UV radiation). Inside the capsule, Liulin-Photo was mounted on the top of the space biology experiment Photo-II to monitor the radiation field around this experiment. The device Photo- II is a system of optical sensors that measured in real time the chlorophyll fluorescence to study the effects of the mixed ionizing space radiations on the photosynthetic activity of several microrganisms modified at the level of the photosynthetic electron transfer chain of Photosystem II. In this study we present the results obtained comparing the dose and flux data collected from the two instruments, in order to get information about the effects produced by the capsule shielding. In particular, we analyse in deeper detail the data corresponding to the passages of the spacecraft above the South Atlantic magnetic Anomaly (SAA) and inside the outer electron belt. A comparison between experimental data and predictions of ionizing radiation environment models is also performed. Moreover, an analysis of some space weather data is conducted to better characterize the space environment in relation to the effect on the biological material during the mission.

  20. Lasercomm system development for high-bandwidth terrestrial communications

    NASA Astrophysics Data System (ADS)

    Juarez, Juan C.; Souza, Katherine T.; Bos, Natalie G.; Brown, Andrea M.; Cannon, Brice M.; Petrillo, Keith G.; Riggins, James L.; Sluz, Joseph E.; Tomey, Hala J.; Venkat, Radha A.

    2016-05-01

    In recent years, various terrestrial free-space optical (FSO) communications systems have been demonstrated to achieve high-bandwidth communications between mobile platforms. The terminal architectures fall into three general categories: (1) single aperture systems with tip/tilt control, (2) multi-aperture system with tip/tilt control, and (3) single aperture systems with tip/tilt control and higher order adaptive optics correction. Terrestrial modem approaches generally use direct detection receivers because they provide high bandwidth capability (0.1-10 Gbps) without the complexity of coherent detection. Modems are often augmented with a mix of forward error correction (FEC), interleaving, and/or retransmission for improved data transport. This paper will present a terminal and modem architecture for a low-SWAP FSO communications system that enables robust, high-bandwidth communications under highly scintillated links as found in terrestrial applications such as air-to-air, air-to-surface, and surface-to-surface links.

  1. Ultrafast pulsed laser utilizing broad bandwidth laser glass

    DOEpatents

    Payne, Stephen A.; Hayden, Joseph S.

    1997-01-01

    An ultrafast laser uses a Nd-doped phosphate laser glass characterized by a particularly broad emission bandwidth to generate the shortest possible output pulses. The laser glass is composed primarily of P.sub.2 O.sub.5, Al.sub.2 O.sub.3 and MgO, and possesses physical and thermal properties that are compatible with standard melting and manufacturing methods. The broad bandwidth laser glass can be used in modelocked oscillators as well as in amplifier modules.

  2. Ultrafast pulsed laser utilizing broad bandwidth laser glass

    DOEpatents

    Payne, S.A.; Hayden, J.S.

    1997-09-02

    An ultrafast laser uses a Nd-doped phosphate laser glass characterized by a particularly broad emission bandwidth to generate the shortest possible output pulses. The laser glass is composed primarily of P{sub 2}O{sub 5}, Al{sub 2}O{sub 3} and MgO, and possesses physical and thermal properties that are compatible with standard melting and manufacturing methods. The broad bandwidth laser glass can be used in modelocked oscillators as well as in amplifier modules. 7 figs.

  3. Exploiting independent filter bandwidth of human factor cepstral coefficients in automatic speech recognition

    NASA Astrophysics Data System (ADS)

    Skowronski, Mark D.; Harris, John G.

    2004-09-01

    Mel frequency cepstral coefficients (MFCC) are the most widely used speech features in automatic speech recognition systems, primarily because the coefficients fit well with the assumptions used in hidden Markov models and because of the superior noise robustness of MFCC over alternative feature sets such as linear prediction-based coefficients. The authors have recently introduced human factor cepstral coefficients (HFCC), a modification of MFCC that uses the known relationship between center frequency and critical bandwidth from human psychoacoustics to decouple filter bandwidth from filter spacing. In this work, the authors introduce a variation of HFCC called HFCC-E in which filter bandwidth is linearly scaled in order to investigate the effects of wider filter bandwidth on noise robustness. Experimental results show an increase in signal-to-noise ratio of 7 dB over traditional MFCC algorithms when filter bandwidth increases in HFCC-E. An important attribute of both HFCC and HFCC-E is that the algorithms only differ from MFCC in the filter bank coefficients: increased noise robustness using wider filters is achieved with no additional computational cost.

  4. Exploiting independent filter bandwidth of human factor cepstral coefficients in automatic speech recognition.

    PubMed

    Skowronski, Mark D; Harris, John G

    2004-09-01

    Mel frequency cepstral coefficients (MFCC) are the most widely used speech features in automatic speech recognition systems, primarily because the coefficients fit well with the assumptions used in hidden Markov models and because of the superior noise robustness of MFCC over alternative feature sets such as linear prediction-based coefficients. The authors have recently introduced human factor cepstral coefficients (HFCC), a modification of MFCC that uses the known relationship between center frequency and critical bandwidth from human psychoacoustics to decouple filter bandwidth from filter spacing. In this work, the authors introduce a variation of HFCC called HFCC-E in which filter bandwidth is linearly scaled in order to investigate the effects of wider filter bandwidth on noise robustness. Experimental results show an increase in signal-to-noise ratio of 7 dB over traditional MFCC algorithms when filter bandwidth increases in HFCC-E. An important attribute of both HFCC and HFCC-E is that the algorithms only differ from MFCC in the filter bank coefficients: increased noise robustness using wider filters is achieved with no additional computational cost.

  5. Source parameters and effects of bandwidth and local geology on high- frequency ground motions observed for aftershocks of the northeastern Ohio earthquake of 31 January 1986

    USGS Publications Warehouse

    Glassmoyer, G.; Borcherdt, R.D.

    1990-01-01

    A 10-station array (GEOS) yielded recordings of exceptional bandwidth (400 sps) and resolution (up to 96 dB) for the aftershocks of the moderate (mb???4.9) earthquake that occurred on 31 January 1986 near Painesville, Ohio. Nine aftershocks were recorded with seismic moments ranging between 9 ?? 1016 and 3 ?? 1019 dyne-cm (MW: 0.6 to 2.3). The aftershock recordings at a site underlain by ???8m of lakeshore sediments show significant levels of high-frequency soil amplification of vertical motion at frequencies near 8, 20 and 70 Hz. Viscoelastic models for P and SV waves incident at the base of the sediments yield estimates of vertical P-wave response consistent with the observed high-frequency site resonances, but suggest additional detailed shear-wave logs are needed to account for observed S-wave response. -from Authors

  6. dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs.

    PubMed

    Liu, Xiaoming; Wu, Chunlei; Li, Chang; Boerwinkle, Eric

    2016-03-01

    The purpose of the dbNSFP is to provide a one-stop resource for functional predictions and annotations for human nonsynonymous single-nucleotide variants (nsSNVs) and splice-site variants (ssSNVs), and to facilitate the steps of filtering and prioritizing SNVs from a large list of SNVs discovered in an exome-sequencing study. A list of all potential nsSNVs and ssSNVs based on the human reference sequence were created and functional predictions and annotations were curated and compiled for each SNV. Here, we report a recent major update of the database to version 3.0. The SNV list has been rebuilt based on GENCODE 22 and currently the database includes 82,832,027 nsSNVs and ssSNVs. An attached database dbscSNV, which compiled all potential human SNVs within splicing consensus regions and their deleteriousness predictions, add another 15,030,459 potentially functional SNVs. Eleven prediction scores (MetaSVM, MetaLR, CADD, VEST3, PROVEAN, 4× fitCons, fathmm-MKL, and DANN) and allele frequencies from the UK10K cohorts and the Exome Aggregation Consortium (ExAC), among others, have been added. The original seven prediction scores in v2.0 (SIFT, 2× Polyphen2, LRT, MutationTaster, MutationAssessor, and FATHMM) as well as many SNV and gene functional annotations have been updated. dbNSFP v3.0 is freely available at http://sites.google.com/site/jpopgen/dbNSFP. PMID:26555599

  7. dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs.

    PubMed

    Liu, Xiaoming; Wu, Chunlei; Li, Chang; Boerwinkle, Eric

    2016-03-01

    The purpose of the dbNSFP is to provide a one-stop resource for functional predictions and annotations for human nonsynonymous single-nucleotide variants (nsSNVs) and splice-site variants (ssSNVs), and to facilitate the steps of filtering and prioritizing SNVs from a large list of SNVs discovered in an exome-sequencing study. A list of all potential nsSNVs and ssSNVs based on the human reference sequence were created and functional predictions and annotations were curated and compiled for each SNV. Here, we report a recent major update of the database to version 3.0. The SNV list has been rebuilt based on GENCODE 22 and currently the database includes 82,832,027 nsSNVs and ssSNVs. An attached database dbscSNV, which compiled all potential human SNVs within splicing consensus regions and their deleteriousness predictions, add another 15,030,459 potentially functional SNVs. Eleven prediction scores (MetaSVM, MetaLR, CADD, VEST3, PROVEAN, 4× fitCons, fathmm-MKL, and DANN) and allele frequencies from the UK10K cohorts and the Exome Aggregation Consortium (ExAC), among others, have been added. The original seven prediction scores in v2.0 (SIFT, 2× Polyphen2, LRT, MutationTaster, MutationAssessor, and FATHMM) as well as many SNV and gene functional annotations have been updated. dbNSFP v3.0 is freely available at http://sites.google.com/site/jpopgen/dbNSFP.

  8. Tunable-Bandwidth Filter System

    NASA Technical Reports Server (NTRS)

    Aye, Tin; Yu, Kevin; Dimov, Fedor; Savant, Gajendra

    2006-01-01

    A tunable-bandwidth filter system (TBFS), now undergoing development, is intended to be part of a remote-sensing multispectral imaging system that will operate in the visible and near infrared spectral region (wavelengths from 400 to 900 nm). Attributes of the TBFS include rapid tunability of the pass band over a wide wavelength range and high transmission efficiency. The TBFS is based on a unique integration of two pairs of broadband Raman reflection holographic filters with two rotating spherical lenses. In experiments, a prototype of the TBFS was shown to be capable of spectral sampling of images in the visible range over a 200-nm spectral range with a spectral resolution of .30 nm. The figure depicts the optical layout of a prototype of the TBFS as part of a laboratory multispectral imaging system for the spectral sampling of color test images in two orthogonal polarizations. Each pair of broadband Raman reflection holographic filters is mounted at an equatorial plane between two halves of a spherical lens. The two filters in each pair are characterized by steep spectral slopes (equivalently, narrow spectral edges), no ripple or side lobes in their pass bands, and a few nanometers of non-overlapping wavelength range between their pass bands. Each spherical lens and thus the filter pair within it is rotated in order to rapidly tune its pass band. The rotations of the lenses are effected by electronically controlled, programmable, high-precision rotation stages. The rotations are coordinated by electronic circuits operating under overall supervision of a personal computer in order to obtain the desired variation of the overall pass bands with time. Embedding the filters inside the spherical lenses increases the range of the hologram incidence angles, making it possible to continuously tune the pass and stop bands of the filters over a wider wavelength range. In addition, each spherical lens also serves as part of the imaging optics: The telephoto lens focuses

  9. Tunable-Bandwidth Filter System

    NASA Technical Reports Server (NTRS)

    Bailey, John W.

    2004-01-01

    A tunable-bandwidth filter system (TBFS), now undergoing development, is intended to be part of a remote sensing multispectral imaging system that will operate in the visible and near infrared spectral region (wavelengths from 400 to 900 nm). Attributes of the TBFS include rapid tunability of the pass band over a wide wavelength range and high transmission efficiency. The TBFS is based on a unique integration of two pairs of broadband Raman reflection holographic filters with two rotating spherical lenses. In experiments, a prototype of the TBFS, was shown to be capable of spectral sampling of images in the visible range over a 200 nm spectral range with a spectral resolution of 30 nm. The figure depicts the optical layout of a prototype of the TBFS as part of a laboratory multispectral imaging system for the spectral sampling of color test images in two orthogonal polarizations. Each pair of broadband Raman reflection holographic filters is mounted at an equatorial plane between two halves of a spherical lens. The two filters in each pair are characterized by steep spectral slopes (equivalently, narrow spectral edges), no ripple or side lobes in their pass bands, and a few nanometers of non-overlapping wavelength range between their pass bands. Each spherical lens and thus the filter pair within it is rotated in order to rapidly tune its pass band. The rotations of are effected by electronically controlled, programmable, high-precision rotation stages. The rotations are coordinated by electronic circuits operating under overall supervision of a personal computer in order to obtain the desired variation of the overall pass bands with time. Embedding the filters inside the spherical lenses increases the range of the hologram incidence angles, making it possible to continuously tune the pass and stop bands of the filters over a wider wavelength range. In addition, each spherical lens also serves as part of the imaging optics: The telephoto lens focuses incoming light

  10. Realization of low frequency and controllable-bandwidth squeezing based on a four-wave-mixing amplifer in rubidium vapor

    SciTech Connect

    Liu, Cunjin; Jing, Jietai; Zhou, Zhifan; Pooser, Raphael C; Hudelist, Florian; Zhang, Weiping

    2011-01-01

    We experimentally demonstrate the creation of two correlated beams generated by a nondegenerate four-wave-mixing amplifier at {lambda} = 795 nm in hot rubidium vapor. We achieve intensity difference squeezing at frequencies as low as 1.5 kHz which is so far the lowest frequency to observe squeezing in an atomic system. The squeezing spans from 5.5 to 16.5 MHz with a maximum squeezing of {approx}5 dB at 1 MHz. We can control the squeezing bandwidth by changing the pump power. Both low frequency and controllable bandwidth squeezing show great potential in sensitivity detection and precise control of the atom optics measurement.

  11. Theoretical investigation of injection-locked high modulation bandwidth quantum cascade lasers.

    PubMed

    Meng, Bo; Wang, Qi Jie

    2012-01-16

    In this study, we report for the first time to our knowledge theoretical investigation of modulation responses of injection-locked mid-infrared quantum cascade lasers (QCLs) at wavelengths of 4.6 μm and 9 μm, respectively. It is shown through a three-level rate equations model that the direct intensity modulation of QCLs gives the maximum modulation bandwidths of ~7 GHz at 4.6 μm and ~20 GHz at 9 μm. By applying the injection locking scheme, we find that the modulation bandwidths of up to ~30 GHz and ~70 GHz can be achieved for QCLs at 4.6 μm and 9 μm, respectively, with an injection ratio of 5 dB. The result also shows that an ultrawide modulation bandwidth of more than 200 GHz is possible with a 10 dB injection ratio for QCLs at 9 μm. An important characteristic of injection-locked QCLs is the nonexistence of unstable locking region in the locking map, in contrast to their diode laser counterparts. We attribute this to the ultra-short upper laser state lifetimes of QCLs.

  12. CONTRAST-ENHANCED INTRAVASCULAR ULTRASOUND PULSE SEQUENCES FOR BANDWIDTH-LIMITED TRANSDUCERS

    PubMed Central

    Maresca, David; Renaud, Guillaume; van Soest, Gijs; Li, Xiang; Zhou, Qifa; Shung, K. Kirk; de Jong, Nico; van der Steen, Antonius F. W.

    2013-01-01

    We demonstrate two methods for vasa vasorum imaging using contrast-enhanced intravascular ultrasound, which can be performed using commercial catheters. Plaque neovascularization was recognized as an independent marker of coronary artery plaque vulnerability. IVUS-based methods to image the microvessels available to date require high bandwidth (−6 dB relative frequency bandwidth >70%), which are not routinely available commercially. We explored the potential of ultraharmonic imaging and chirp reversal imaging for vasa vasorum imaging. In vitro recordings were performed on a tissue-mimicking phantom using a commercial ultrasound contrast agent and a transducer with a center frequency of 34 MHz and a −6 dB relative bandwidth of 56%. Acoustic peak pressures <500 kPa were used. A tissue-mimicking phantom with channels down to 200 μm in diameter was successfully imaged by the two contrast detection sequences while the smallest channel stayed invisible in conventional intravascular ultrasound images. Ultraharmonic imaging provided the best contrast agent detection. PMID:23384459

  13. Bandwidth-tunable narrowband rectangular optical filter based on stimulated Brillouin scattering in optical fiber.

    PubMed

    Wei, Wei; Yi, Lilin; Jaouën, Yves; Hu, Weisheng

    2014-09-22

    We propose a rectangular optical filter based on stimulated Brillouin scattering (SBS) in optical fiber with bandwidth tuning from 50 MHz to 4 GHz at less than 15-MHz resolution. The rectangular shape of the filter is precisely achieved utilizing digital feedback control of the comb-like pump spectral lines. The passband ripple is suppressed to ~1 dB by mitigating the nonlinearity influences of the comb-like pump lines generated in electrical and optical components and fibers. Moreover a fiber with a single Brillouin peak is employed to further reduce the in-band ripple and the out-of-band SBS gain at the same time. Finally, we analyze the noise performance of the filter at different bandwidth cases and demonstrate the system performance of the proposed filter with 2.1-GHz bandwidth and 19-dB gain by amplifying a 2-GHz orthogonal frequency-division-multiplexing (OFDM) signal with quadrature-phase-shift-keying (QPSK) and 16-quadrature-amplitude-modulation (16-QAM) on each subscriber.

  14. High bandwidth control of precision motion instrumentation

    NASA Astrophysics Data System (ADS)

    Bristow, Douglas A.; Dong, Jingyan; Alleyne, Andrew G.; Ferreira, Placid; Salapaka, Srinivas

    2008-10-01

    This article presents a high-bandwidth control design suitable for precision motion instrumentation. Iterative learning control (ILC), a feedforward technique that uses previous iterations of the desired trajectory, is used to leverage the repetition that occurs in many tasks, such as raster scanning in microscopy. Two ILC designs are presented. The first design uses the motion system dynamic model to maximize bandwidth. The second design uses a time-varying bandwidth that is particularly useful for nonsmooth trajectories such as raster scanning. Both designs are applied to a multiaxis piezoelectric-actuated flexure system and evaluated on a nonsmooth trajectory. The ILC designs demonstrate significant bandwidth and precision improvements over the feedback controller, and the ability to achieve precision motion control at frequencies higher than multiple system resonances.

  15. Paired comparisons of nonlinear frequency compression, extended bandwidth, and restricted bandwidth hearing-aid processing for children and adults with hearing loss

    PubMed Central

    Brennan, Marc A.; McCreery, Ryan; Kopun, Judy; Hoover, Brenda; Alexander, Joshua; Lewis, Dawna; Stelmachowicz, Patricia G.

    2014-01-01

    Background Preference for speech and music processed with nonlinear frequency compression and two controls (restricted and extended bandwidth hearing-aid processing) was examined in adults and children with hearing loss. Purpose Determine if stimulus type (music, sentences), age (children, adults) and degree of hearing loss influence listener preference for nonlinear frequency compression, restricted bandwidth and extended bandwidth. Research Design Within-subject, quasi-experimental study. Using a round-robin procedure, participants listened to amplified stimuli that were 1) frequency-lowered using nonlinear frequency compression, 2) low-pass filtered at 5 kHz to simulate the restricted bandwidth of conventional hearing aid processing, or 3) low-pass filtered at 11 kHz to simulate extended bandwidth amplification. The examiner and participants were blinded to the type of processing. Using a two-alternative forced-choice task, participants selected the preferred music or sentence passage. Study Sample Sixteen children (8–16 years) and 16 adults (19–65 years) with mild-to-severe sensorineural hearing loss. Intervention All subjects listened to speech and music processed using a hearing-aid simulator fit to the Desired Sensation Level algorithm v.5.0a (Scollie et al, 2005). Results Children and adults did not differ in their preferences. For speech, participants preferred extended bandwidth to both nonlinear frequency compression and restricted bandwidth. Participants also preferred nonlinear frequency compression to restricted bandwidth. Preference was not related to degree of hearing loss. For music, listeners did not show a preference. However, participants with greater hearing loss preferred nonlinear frequency compression to restricted bandwidth more than participants with less hearing loss. Conversely, participants with greater hearing loss were less likely to prefer extended bandwidth to restricted bandwidth. Conclusion Both age groups preferred access to

  16. Broad-bandwidth near-shot-noise-limited intensity noise suppression of a single-frequency fiber laser.

    PubMed

    Zhao, Qilai; Xu, Shanhui; Zhou, Kaijun; Yang, Changsheng; Li, Can; Feng, Zhouming; Peng, Mingying; Deng, Huaqiu; Yang, Zhongmin

    2016-04-01

    A significant broad-bandwidth near-shot-noise-limited intensity noise suppression of a single-frequency fiber laser is demonstrated based on a semiconductor optical amplifier (SOA) with optoelectronic feedback. By exploiting the gain saturation effect of the SOA and the intensity feedback loop, a maximum noise suppression of over 50 dB around the relaxation oscillation frequencies and a suppression bandwidth of up to 50 MHz are obtained. The relative intensity noise of -150  dB/Hz in the frequency range from 0.8 kHz to 50 MHz is achieved, which approaches the shot-noise limit. The obtained optical signal-to-noise ratio is more than 70 dB. This near-shot-noise-limited laser source shows important implications for the advanced fields of high-precision frequency stabilization, quantum key distribution, and gravitational wave detection. PMID:27192229

  17. Ultra-wide bandwidth with enhanced microwave absorption of electroless Ni-P coated tetrapod-shaped ZnO nano- and microstructures.

    PubMed

    Najim, Mohd; Modi, Gaurav; Mishra, Yogendra Kumar; Adelung, Rainer; Singh, Dharmendra; Agarwala, Vijaya

    2015-09-21

    A viable lightweight absorber is the current need for stealth technology as well as microwave absorption. Several microwave absorbers have been developed, but it is still a challenge to fabricate an absorber that facilitates microwave absorption in broad bandwidth or covers the maximum portion of the frequency range 2-18 GHz, the commonly used range for radar and other applications. Therefore, it is highly required to develop a wide bandwidth absorber that can provide microwave absorption in the most part of the frequency range 2-18 GHz while simultaneously being lightweight and can be fabricated in desired bulk quantities by the cost-effective synthesis methods. In this paper, an attempt has been made to design an ultra-wide bandwidth absorber with enhanced microwave absorption response by using nickel-phosphorus coated tetrapod-shaped ZnO (Ni-P coated T-ZnO). In the Ni-P coated T-ZnO absorber, ZnO acts as a good dielectric contributor, while Ni as a magnetic constituent to obtain a microwave absorbing composite material, which has favorable absorption properties. Ni-P coated ZnO nano-microstructures are synthesized by a simple and scalable two-step process. First, tetrapod-shaped ZnO (T-ZnO) structures have been grown by the flame transport synthesis (FTS) approach in a single step process and then they have been coated with Ni-P by an electroless coating technique. Their morphology, degree of crystallinity and existing phases were studied in detail by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD) techniques. The complex permittivity and permeability of the "as-fabricated" T-ZnO and Ni-P coated T-ZnO have been measured in the frequency range of 4-14 GHz and their microwave absorption properties are computed using the coaxial transmission-reflection method. The strongest reflection loss (RL) peak value of -36.41 dB has been obtained at a frequency of ∼8.99 GHz with coating thickness of 3.4 mm for the Ni

  18. Ultra-wide bandwidth with enhanced microwave absorption of electroless Ni-P coated tetrapod-shaped ZnO nano- and microstructures.

    PubMed

    Najim, Mohd; Modi, Gaurav; Mishra, Yogendra Kumar; Adelung, Rainer; Singh, Dharmendra; Agarwala, Vijaya

    2015-09-21

    A viable lightweight absorber is the current need for stealth technology as well as microwave absorption. Several microwave absorbers have been developed, but it is still a challenge to fabricate an absorber that facilitates microwave absorption in broad bandwidth or covers the maximum portion of the frequency range 2-18 GHz, the commonly used range for radar and other applications. Therefore, it is highly required to develop a wide bandwidth absorber that can provide microwave absorption in the most part of the frequency range 2-18 GHz while simultaneously being lightweight and can be fabricated in desired bulk quantities by the cost-effective synthesis methods. In this paper, an attempt has been made to design an ultra-wide bandwidth absorber with enhanced microwave absorption response by using nickel-phosphorus coated tetrapod-shaped ZnO (Ni-P coated T-ZnO). In the Ni-P coated T-ZnO absorber, ZnO acts as a good dielectric contributor, while Ni as a magnetic constituent to obtain a microwave absorbing composite material, which has favorable absorption properties. Ni-P coated ZnO nano-microstructures are synthesized by a simple and scalable two-step process. First, tetrapod-shaped ZnO (T-ZnO) structures have been grown by the flame transport synthesis (FTS) approach in a single step process and then they have been coated with Ni-P by an electroless coating technique. Their morphology, degree of crystallinity and existing phases were studied in detail by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD) techniques. The complex permittivity and permeability of the "as-fabricated" T-ZnO and Ni-P coated T-ZnO have been measured in the frequency range of 4-14 GHz and their microwave absorption properties are computed using the coaxial transmission-reflection method. The strongest reflection loss (RL) peak value of -36.41 dB has been obtained at a frequency of ∼8.99 GHz with coating thickness of 3.4 mm for the Ni

  19. Effective Communication and File-I/O Bandwidth Benchmarks

    SciTech Connect

    Koniges, A E; Rabenseifner, R

    2001-05-02

    We describe the design and MPI implementation of two benchmarks created to characterize the balanced system performance of high-performance clusters and supercomputers: b{_}eff, the communication-specific benchmark examines the parallel message passing performance of a system, and b{_}eff{_}io, which characterizes the effective 1/0 bandwidth. Both benchmarks have two goals: (a) to get a detailed insight into the Performance strengths and weaknesses of different parallel communication and I/O patterns, and based on this, (b) to obtain a single bandwidth number that characterizes the average performance of the system namely communication and 1/0 bandwidth. Both benchmarks use a time driven approach and loop over a variety of communication and access patterns to characterize a system in an automated fashion. Results of the two benchmarks are given for several systems including IBM SPs, Cray T3E, NEC SX-5, and Hitachi SR 8000. After a redesign of b{_}eff{_}io, I/O bandwidth results for several compute partition sizes are achieved in an appropriate time for rapid benchmarking.

  20. The FourStar Galaxy Evolution Survey (ZFOURGE): Ultraviolet to Far-infrared Catalogs, Medium-bandwidth Photometric Redshifts with Improved Accuracy, Stellar Masses, and Confirmation of Quiescent Galaxies to z ∼ 3.5

    NASA Astrophysics Data System (ADS)

    Straatman, Caroline M. S.; Spitler, Lee R.; Quadri, Ryan F.; Labbé, Ivo; Glazebrook, Karl; Persson, S. Eric; Papovich, Casey; Tran, Kim-Vy H.; Brammer, Gabriel B.; Cowley, Michael; Tomczak, Adam; Nanayakkara, Themiya; Alcorn, Leo; Allen, Rebecca; Broussard, Adam; van Dokkum, Pieter; Forrest, Ben; van Houdt, Josha; Kacprzak, Glenn G.; Kawinwanichakij, Lalitwadee; Kelson, Daniel D.; Lee, Janice; McCarthy, Patrick J.; Mehrtens, Nicola; Monson, Andrew; Murphy, David; Rees, Glen; Tilvi, Vithal; Whitaker, Katherine E.

    2016-10-01

    The FourStar galaxy evolution survey (ZFOURGE) is a 45 night legacy program with the FourStar near-infrared camera on Magellan and one of the most sensitive surveys to date. ZFOURGE covers a total of 400 arcmin2 in cosmic fields CDFS, COSMOS and UDS, overlapping CANDELS. We present photometric catalogs comprising >70,000 galaxies, selected from ultradeep K s -band detection images (25.5–26.5 AB mag, 5σ, total), and >80% complete to K s < 25.3–25.9 AB. We use 5 near-IR medium-bandwidth filters (J 1, J 2, J 3, H s , H l ) as well as broad-band K s at 1.05–2.16 μm to 25–26 AB at a seeing of ∼0.″5. Each field has ancillary imaging in 26–40 filters at 0.3–8 μm. We derive photometric redshifts and stellar population properties. Comparing with spectroscopic redshifts indicates a photometric redshift uncertainty σ z = 0.010, 0.009, and 0.011 in CDFS, COSMOS, and UDS. As spectroscopic samples are often biased toward bright and blue sources, we also inspect the photometric redshift differences between close pairs of galaxies, finding σ z,pairs = 0.01–0.02 at 1 < z < 2.5. We quantify how σ z,pairs depends on redshift, magnitude, spectral energy distribution type, and the inclusion of FourStar medium bands. σ z,pairs is smallest for bright, blue star-forming samples, while red star-forming galaxies have the worst σ z,pairs. Including FourStar medium bands reduces σ z,pairs by 50% at 1.5 < z < 2.5. We calculate star formation rates (SFRs) based on ultraviolet and ultradeep far-IR Spitzer/MIPS and Herschel/PACS data. We derive rest-frame U ‑ V and V ‑ J colors, and illustrate how these correlate with specific SFR and dust emission to z = 3.5. We confirm the existence of quiescent galaxies at z ∼ 3, demonstrating their SFRs are suppressed by > ×15. This paper contains data gathered with the 6.5 meter Magellan Telescopes located at Las Campanas observatory, Chile

  1. Bandwidth-efficient phase modulation techniques for stimulated Brillouin scattering suppression in fiber optic parametric amplifiers.

    PubMed

    Coles, J B; Kuo, B P-P; Alic, N; Moro, S; Bres, C-S; Chavez Boggio, J M; Andrekson, P A; Karlsson, M; Radic, S

    2010-08-16

    Two novel bandwidth efficient pump-dithering Stimulated Brillouin Scattering (SBS) suppression techniques are introduced. The techniques employ a frequency-hopped chirp and an RF noise source to impart phase modulation on the pumps of a two pump Fiber Optical Parametric Amplifier (FOPA). The effectiveness of the introduced techniques is confirmed by measurements of the SBS threshold increase and the associated improvements relative to the current state of the art. Additionally, the effect on the idler signal integrity is presented as measured following amplification from a two pump FOPA employing both techniques. The measured 0.8 dB penalty with pumps dithered by an RF noise source, after accruing 160 ps/nm of dispersion with 38 dB conversion gain in a two-pump FOPA is the lowest reported to date.

  2. Towards optimum demodulation of bandwidth-limited and low SNR square-wave subcarrier signals

    NASA Technical Reports Server (NTRS)

    Feria, Y.; Hurd, W.

    1995-01-01

    The optimum phase detector is presented for tracking square-wave subcarriers that have been bandwidth limited to a finite number of harmonics. The phase detector is optimum in the sense that the loop signal-to-noise ratio (SNR) is maximized and, hence, the rms phase tracking error is minimized. The optimum phase detector is easy to implement and achieves substantial improvement. Also presented are the optimum weights to combine the signals demodulated from each of the harmonics. The optimum weighting provides SNR improvement of 0.1 to 0.15 dB when the subcarrier loop SNR is low (15 dB) and the number of harmonics is high (8 to 16).

  3. Detailed study of macrobending effects in a wide transmission bandwidth hollow-core photonic bandgap fiber

    NASA Astrophysics Data System (ADS)

    Chen, Y.; Sandoghchi, S. R.; Numkam, E.; Bradley, T. D.; Hayes, J. R.; Wheeler, N. V.; Jasion, G.; Gray, D. R.; Poletti, F.; Petrovich, M. N.; Richardson, D. J.

    2016-04-01

    We study in detail the macrobending effects in a wide transmission bandwidth (~200nm) 19 cell hollow-core photonic bandgap fiber operating at 1550nm. Our results indicate low bend sensitivity over a ~130nm wide interval within the transmission window, with negligible loss (<0.1dB) for bending radii down to 5mm. The "red shift" and "blue shift" of the bandgap edge have been observed at the short and long wavelength edges, respectively. The cutoff wavelengths where air-guiding modes stop guiding can be extracted from the bending loss spectra, which matches well with the simulated effective refractive index map of such fiber.

  4. Magnetic field dependence of the magnetic susceptibility and the specific heat of the doped plasticized polyaniline (PANI-DB3EPSA)0.5.

    PubMed

    Djurado, D; Pron, A; Jacquot, J F; Travers, J P; Adriano, C; Vargas, J M; Pagliuso, P G; Rettori, C; Lesseux, G G; Fier, I; Walmsley, L

    2011-05-25

    Specific heat, magnetization and electron spin resonance (ESR) data obtained from a self-standing film of the doped plasticized polyaniline (PANI-DB3EPSA)(0.5) are shown. No long range magnetic order has been observed at zero magnetic field, above 2 K. For a magnetic field of 3.3 kOe applied perpendicular to the plane of the film, a clear signature of an induced ordered state can be seen in the specific heat data and ESR also reveals this antiferromagnetic order. An electronic contribution is detected from ESR, magnetization and specific heat; however, for T ≤ 5 K, the specific heat data show the existence of a gap. Magnetization data also show a low temperature dominant Curie behaviour which cannot be seen from ESR, probably due to a very large linewidth, suggesting short range correlations among spin 1/2 polarons.

  5. Relative loudness of low- and high-frequency bands of speech-shaped babble, including the influence of bandwidth and input level

    NASA Astrophysics Data System (ADS)

    Keidser, Gitte; Katsch, Richard; Dillon, Harvey; Grant, Frances

    2002-02-01

    In a balancing test, ten normal-hearing listeners adjusted filtered speech-shaped babble-noise to equally loud levels. On average, they selected about 10 dB less gain for bands below 1 kHz than for bands above and including 1 kHz. The findings applied to two bandwidths (octave and equivalent rectangular bandwidth) and two levels (65 and 85 dB SPL). The outcome suggests that hearing aid fitting procedures aiming to equalize loudness of speech bands should prescribe less low-frequency gain than procedures aiming to normalize loudness of speech bands. A significant interaction was found between bandwidth and input level for the high-frequency bands.

  6. An Extremely Wide Bandwidth, Low-Noise SIS Heterodyne Receiver Design for Millimeter and Submillimeter Observations

    NASA Technical Reports Server (NTRS)

    Sumner, Matthew; Blain, Andrew; Harris, Andrew; Hu, Robert; Rice, Frank; LeDuc, H. G.; Weinreb, Sander; Zmuidzinas, Jonas

    2002-01-01

    Millimeter and submillimeter heterodyne receivers using state-of-the-art SIS detectors are capable of extremely large instantaneous bandwidths with noise temperatures within a few Kelvin of the quantum limit. We present the design for a broadband, sensitive, heterodyne spectrometer under development for the Caltech Submillimeter Observatory (CSO). The 180-300 GHz double-sideband design uses a single SIS device excited by a full bandwidth, fixed-tuned waveguide probe on a silicon substrate. The IF output frequency (limited by the MMIC low noise IF preamplifier) is 6-18 GHz, providing an instantaneous RF bandwidth of 24 GHz (double-sideband). The SIS mixer conversion loss should be no more than 1-2 dB with mixer noise temperatures across the band within 10 K of the quantum limit. The single-sideband receiver noise temperature goal is 70 K. The wide instantaneous bandwidth and low noise will result in an instrument capable of a variety of important astrophysical observations beyond the capabilities of current instruments. Lab testing of the receiver will begin in the summer of 2002, and the first use on the CSO should occur in the spring of 2003.

  7. An Extremely Wide Bandwidth, Low Noise SIS Heterodyne Receiver Design for Millimeter and Submillimeter Observations

    NASA Technical Reports Server (NTRS)

    Zmuidzinas, J.

    2004-01-01

    Our group has designed a heterodyne submillimeter receiver that offers a very wide IF bandwidth of 12 GHz, while still maintaining a low noise temperature. The 180-300 GHz double-sideband design uses a single SI5 device excited by a full bandwidth, fixed-tuned waveguide probe on a silicon substrate. The IF output frequency (limited by the MMIC low noise IF preamplifier) is 6-18 GHz. providing an instantaneous RF bandwidth of 24 GHz (double-sideband). Intensive simulations predict that the junction will achieve a conversion loss better than 1-2 dB and a mixer noise temperature of less than 20 K across the band (twice the quantum limit). The single sideband receiver noise temperature goal is 70 K. The wide instantaneous bandwidth and low noise will result in an instrument capable of a variety of important astrophysical and environmental observations beyond the capabilities of current instruments. Lab testing of the receiver will begin this summer, and first light on the CSO should be in the Spring of 2003. At the CSO, we plan to use receiver with WASP2, a wideband spectrometer, to search for spectral lines from SCUBA sources. This approach should allow us to rapidly develop a catalog of redshifts for these objects.

  8. Broadband and High Sensitive Time-of-Flight Diffraction Ultrasonic Transducers Based on PMNT/Epoxy 1–3 Piezoelectric Composite

    PubMed Central

    Liu, Dongxu; Yue, Qingwen; Deng, Ji; Lin, Di; Li, Xiaobing; Di, Wenning; Wang, Xi’an; Zhao, Xiangyong; Luo, Haosu

    2015-01-01

    5–6 MHz PMNT/epoxy 1–3 composites were prepared by a modified dice-and-fill method. They exhibit excellent properties for ultrasonic transducer applications, such as ultrahigh thickness electromechanical coupling coefficient kt (85.7%), large piezoelectric coefficient d33 (1209 pC/N), and relatively low acoustic impedance Z (1.82 × 107 kg/(m2·s)). Besides, two types of Time-of-Flight Diffraction (TOFD) ultrasonic transducers have been designed, fabricated, and characterized, which have different matching layer schemes with the acoustic impedance of 4.8 and 5.7 × 106 kg/(m2·s), respectively. In the detection on a backwall of 12.7 mm polystyrene, the former exhibits higher detectivity, the relative pulse-echo sensitivity and −6 dB relative bandwidth are −21.93 dB and 102.7%, respectively, while the later exhibits broader bandwidth, the relative pulse-echo sensitivity and −6 dB relative bandwidth are −24.08 dB and 117.3%, respectively. These TOFD ultrasonic transducers based on PMNT/epoxy 1–3 composite exhibit considerably improved performance over the commercial PZT/epoxy 1–3 composite TOFD ultrasonic transducer. PMID:25808776

  9. Improved Cross Polarization and Broad Impedance Bandwidth from Simple Single Element Shorted Rectangular Microstrip Patch: Theory and Experiment

    NASA Astrophysics Data System (ADS)

    Poddar, Rakshapada; Chakraborty, Subhradeep; Chattopadhyay, Sudipta

    2016-01-01

    A simple, compact and single element rectangular microstrip antenna with three pairs of shorting plates has been proposed and investigated experimentally for broad impedance bandwidth and improved cross polarized (XP) radiation compared to maximum co-polarized (CO) gain without affecting the co-polarized radiation pattern. Around 25-40 dB isolation between copolarized radiation to cross polarized radiation (CO-XP isolation) along with 1.32 GHz impedance bandwidth is achieved with the proposed structure. The present structure is very simple and easy to manufacture and provides high CO-XP isolation over entire angular range around the broadside direction. Moreover, the present structure is free from back radiation in terms of XP fields. The present investigation provides an insightful, visualization-based understanding of concurrent improvement in impedance bandwidth and the XP radiation characteristics with the present structure.

  10. Antenna array bandwidth enhancement using polymeric nanocomposite substrate

    NASA Astrophysics Data System (ADS)

    Muhamad, W. A. W.; Ngah, R.; Jamlos, M. F.; Soh, P. J.; Jamlos, M. A.; Lago, H.

    2016-04-01

    A 4 × 2 array antenna is developed using a new nanocomposite polymeric magneto-dielectric substrate. The permittivity and permeability factors have been accounted in designing the proposed array antenna at the frequency of 2.6 GHz. A pure polydimethylsiloxane (P-PDMS) (ɛ r = 2.7) solution is mixed with ferrite III oxide (μ r = 1.2) to generate this new nanocomposite polymeric magneto-dielectric (NPMD) substrate. The NPMD surface is then hardened and located in between two P-PDMS layers. The 4 × 2 radiating elements are immersed to the top of P-PDMS layer, while SMA coaxial feeder is fed from underneath the ground layer. This sealing technique enabled the proposed antenna to be waterproof and flexible. This combination contributes to bandwidth enhancement of 52.65 %, size miniaturization of 176 × 156 mm2 and high gain of 10.8 dB. The measured results show a good agreement with simulations.

  11. HRD1-Mediated IGF-1R Ubiquitination Contributes to Renal Protection of Resveratrol in db/db Mice.

    PubMed

    Yan, Caifeng; Xu, Weifeng; Huang, Yujie; Li, Min; Shen, Yachen; You, Hui; Liang, Xiubin

    2016-06-01

    Many studies have provided evidence to demonstrate the beneficial renal effects of resveratrol (RESV) due to its antioxidant character and its capacity for activation of surtuin 1. However, the molecular mechanisms underlying the protective role of RESV against kidney injury are still incompletely understood. The present study used Lepr db/db (db/db) and Lepr db/m (db/m) mice as models to evaluate the effect of RESV on diabetic nephropathy (DN). RESV reduced proteinuria and attenuated the progress of renal fibrosis in db/db mice. Treatment with RESV markedly attenuated the diabetes-induced changes in renal superoxide dismutase copper/zinc, superoxide dismutase manganese, catalase, and malonydialdehyde as well as the renal expression of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4), α-smooth muscle actin (α-SMA), and E-cadherin in db/db mice. The kidney expression of the IGF-1 receptor (IGF-1R) was increased in db/db mice, but the expression of 3-hydroxy-3-methylglutaryl reductase degradation (HRD1), a ubiquitin E3 ligase, was significantly decreased in the DN model. RESV treatment dramatically decreased IGF-1R and increased HRD1 expressions, consistent with data obtained with HKC-8 cells. HRD1 physically interacted with IGF-1R in HKC-8 cells and liquid chromatography and tandem mass spectrometry (LC-MS/MS) data supported the concept that IGF-1R is one of the HRD1 substrates. HRD1 promoted the IGF-1R ubiquitination for degradation in HKC-8 cells, and the down-regulation of HRD1 reversed the protective effects of RESV in HKC-8 cells. In summary, we have demonstrated that RESV reduces proteinuria and attenuates the progression of renal fibrosis in db/db mice. These protective effects of RESV on DN were associated with the up-regulation of HRD1, induced by RESV, and the promotion of IGF-1R ubiquitination and degradation.

  12. Vertical-bandwidth-limited digital holography.

    PubMed

    Liu, Jung-Ping; Lee, Chieh-Cheng; Lo, Ying-Hau; Luo, Dao-Zheng

    2012-07-01

    Optical scanning holography (OSH) is a promising technique to acquire a big-size digital hologram. However, the acquisition speed is limited by the mechanical scanner. In this Letter we apply the OSH in conjunction with an anisotropic low-pass filtering pupil to acquire vertical-bandwidth-limited (VBL) holograms. The size and the acquisition time of the VBL hologram can be reduced by one order of magnitude while the horizontal resolution remains the same as the conventional scanning hologram. The VBL hologram can be coded as an off-axis hologram without any postfiltering. Meanwhile, the full horizontal bandwidth of the displaying device can be capitalized.

  13. 47 CFR 87.135 - Bandwidth of emission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bandwidth of emission. 87.135 Section 87.135... Technical Requirements § 87.135 Bandwidth of emission. (a) Occupied bandwidth is the width of a frequency... equal to 0.5 percent of the total mean power of a given emission. (b) The authorized bandwidth is...

  14. 47 CFR 87.135 - Bandwidth of emission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bandwidth of emission. 87.135 Section 87.135... Technical Requirements § 87.135 Bandwidth of emission. (a) Occupied bandwidth is the width of a frequency... equal to 0.5 percent of the total mean power of a given emission. (b) The authorized bandwidth is...

  15. Oxamate Improves Glycemic Control and Insulin Sensitivity via Inhibition of Tissue Lactate Production in db/db Mice

    PubMed Central

    Ye, Weiran; Zheng, Yijia; Zhang, Shanshan; Yan, Li; Cheng, Hua; Wu, Muchao

    2016-01-01

    Oxamate (OXA) is a pyruvate analogue that directly inhibits the lactate dehydrogenase (LDH)-catalyzed conversion process of pyruvate into lactate. Earlier and recent studies have shown elevated blood lactate levels among insulin-resistant and type 2 diabetes subjects and that blood lactate levels independently predicted the development of incident diabetes. To explore the potential of OXA in the treatment of diabetes, db/db mice were treated with OXA in vivo. Treatment of OXA (350–750 mg/kg of body weight) for 12 weeks was shown to decrease body weight gain and blood glucose and HbA1c levels and improve insulin secretion, the morphology of pancreatic islets, and insulin sensitivity in db/db mice. Meanwhile, OXA reduced the lactate production of adipose tissue and skeletal muscle and serum lactate levels and decreased serum levels of TG, FFA, CRP, IL-6, and TNF-α in db/db mice. The PCR array showed that OXA downregulated the expression of Tnf, Il6, leptin, Cxcr3, Map2k1, and Ikbkb, and upregulated the expression of Irs2, Nfkbia, and Pde3b in the skeletal muscle of db/db mice. Interestingly, LDH-A expression increased in the islet cells of db/db mice, and both treatment of OXA and pioglitazone decreased LDH-A expression, which might be related to the improvement of insulin secretion. Taken together, increased lactate production of adipose tissue and skeletal muscle may be at least partially responsible for insulin resistance and diabetes in db/db mice. OXA improved glycemic control and insulin sensitivity in db/db mice primarily via inhibition of tissue lactate production. Oxamic acid derivatives may be a potential drug for the treatment of type 2 diabetes. PMID:26938239

  16. Oxamate Improves Glycemic Control and Insulin Sensitivity via Inhibition of Tissue Lactate Production in db/db Mice.

    PubMed

    Ye, Weiran; Zheng, Yijia; Zhang, Shanshan; Yan, Li; Cheng, Hua; Wu, Muchao

    2016-01-01

    Oxamate (OXA) is a pyruvate analogue that directly inhibits the lactate dehydrogenase (LDH)-catalyzed conversion process of pyruvate into lactate. Earlier and recent studies have shown elevated blood lactate levels among insulin-resistant and type 2 diabetes subjects and that blood lactate levels independently predicted the development of incident diabetes. To explore the potential of OXA in the treatment of diabetes, db/db mice were treated with OXA in vivo. Treatment of OXA (350-750 mg/kg of body weight) for 12 weeks was shown to decrease body weight gain and blood glucose and HbA1c levels and improve insulin secretion, the morphology of pancreatic islets, and insulin sensitivity in db/db mice. Meanwhile, OXA reduced the lactate production of adipose tissue and skeletal muscle and serum lactate levels and decreased serum levels of TG, FFA, CRP, IL-6, and TNF-α in db/db mice. The PCR array showed that OXA downregulated the expression of Tnf, Il6, leptin, Cxcr3, Map2k1, and Ikbkb, and upregulated the expression of Irs2, Nfkbia, and Pde3b in the skeletal muscle of db/db mice. Interestingly, LDH-A expression increased in the islet cells of db/db mice, and both treatment of OXA and pioglitazone decreased LDH-A expression, which might be related to the improvement of insulin secretion. Taken together, increased lactate production of adipose tissue and skeletal muscle may be at least partially responsible for insulin resistance and diabetes in db/db mice. OXA improved glycemic control and insulin sensitivity in db/db mice primarily via inhibition of tissue lactate production. Oxamic acid derivatives may be a potential drug for the treatment of type 2 diabetes. PMID:26938239

  17. ZipperDB: Predictions of Fibril-forming Segments within Proteins Identified by the 3D Profile Method (from the UCLA-DOE Institute for Genomics and Proteomics)

    DOE Data Explorer

    Goldschmidt, L.; Teng, P. K.; Riek, R.; Eisenberg, D.

    ZipperDB contains predictions of fibril-forming segments within proteins identified by the 3D Profile Method. The UCLA-DOE Institute for Genomics and Proteomics has analyzed over 20,000 putative protein sequences for segments with high fibrillation propensity that could form a "steric zipper"ùtwo self-complementary beta sheets, giving rise to the spine of an amyloid fibril. The approach is unique in that structural information is used to evaluate the likelihood that a particular sequence can form fibrils. [copied with edits from http://www.doe-mbi.ucla.edu/]. In addition to searching the database, academic and non-profit users may also submit their protein sequences to the database.

  18. Renal and glycemic effects of high-dose chromium picolinate in db/db mice: assessment of DNA damage.

    PubMed

    Mozaffari, Mahmood S; Baban, Babak; Abdelsayed, Rafik; Liu, Jun Yao; Wimborne, Hereward; Rodriguez, Nancy; Abebe, Worku

    2012-08-01

    This study examined renal and glycemic effects of chromium picolinate [Cr(pic)3] supplementation in the context of its purported potential for DNA damage. In preventional protocol, male obese diabetic db/db mice were fed diets either lacking or containing 5, 10 or 100 mg/kg chromium as Cr(pic)3 from 6 to 24 weeks of age; male lean nondiabetic db/m mice served as controls. Untreated db/db mice displayed increased plasma glucose and insulin, hemoglobin A1c, renal tissue advanced glycation end products, albuminuria, glomerular mesangial expansion, urinary 8-hydroxydeoxyguanosine (an index of oxidative DNA damage) and renal tissue immunostaining for γH2AX (a marker of double-strand DNA breaks) compared to db/m controls. Creatinine clearance was lower in untreated db/db mice than their db/m controls, while blood pressure was similar. High Cr(pic)3 intake (i.e., 100-mg/kg diet) mildly improved glycemic status and albuminuria without affecting blood pressure or creatinine clearance. Treatment with Cr(pic)3 did not increase DNA damage despite marked renal accumulation of chromium. In interventional protocol, effects of diets containing 0, 100 and 250 mg/kg supplemental chromium, from 12 to 24 weeks of age, were examined in db/db mice. The results generally revealed similar effects to those of the 100-mg/kg diet of the preventional protocol. In conclusion, the severely hyperglycemic db/db mouse displays renal structural and functional abnormalities in association with DNA damage. High-dose Cr(pic)3 treatment mildly improves glycemic control, and it causes moderate reduction in albuminuria, without affecting the histopathological appearance of the kidney and increasing the risk for DNA damage.

  19. 47 CFR 24.131 - Authorized bandwidth.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... will be 10 kHz for 12.5 kHz channels and 45 kHz for 50 kHz channels. For aggregated adjacent channels, a maximum authorized bandwidth of 5 kHz less than the total aggregated channel width is permitted....

  20. Increasing the quantitative bandwidth of NMR measurements.

    PubMed

    Power, J E; Foroozandeh, M; Adams, R W; Nilsson, M; Coombes, S R; Phillips, A R; Morris, G A

    2016-02-18

    The frequency range of quantitative NMR is increased from tens to hundreds of kHz by a new pulse sequence, CHORUS. It uses chirp pulses to excite uniformly over very large bandwidths, yielding accurate integrals even for nuclei such as (19)F that have very wide spectra. PMID:26789115

  1. Bandwidth Enabled Flight Operations: Examining the Possibilities

    NASA Technical Reports Server (NTRS)

    Pisanich, Greg; Renema, Fritz; Clancy, Dan (Technical Monitor)

    2002-01-01

    The Bandwidth Enabled Flight Operations project is a research effort at the NASA Ames Research Center to investigate the use of satellite communications to improve aviation safety and capacity. This project is a follow on to the AeroSAPIENT Project, which demonstrated methods for transmitting high bandwidth data in various configurations. For this research, we set a goal to nominally use only 10 percent of the available bandwidth demonstrated by AeroSAPIENT or projected by near-term technology advances. This paper describes the results of our research, including available satellite bandwidth, commercial and research efforts to provide these services, and some of the limiting factors inherent with this communications medium. It also describes our investigation into the needs of the stakeholders (Airlines, Pilots, Cabin Crews, ATC, Maintenance, etc). The paper also describes our development of low-cost networked flight deck and airline operations center simulations that were used to demonstrate two application areas: Providing real time weather information to the commercial flight deck, and enhanced crew monitoring and control for airline operations centers.

  2. Fast Faraday Cup With High Bandwidth

    SciTech Connect

    Deibele, Craig E

    2006-03-14

    A circuit card stripline Fast Faraday cup quantitatively measures the picosecond time structure of a charged particle beam. The stripline configuration maintains signal integrity, and stitching of the stripline increases the bandwidth. A calibration procedure ensures the measurement of the absolute charge and time structure of the charged particle beam.

  3. Increasing the quantitative bandwidth of NMR measurements.

    PubMed

    Power, J E; Foroozandeh, M; Adams, R W; Nilsson, M; Coombes, S R; Phillips, A R; Morris, G A

    2016-02-18

    The frequency range of quantitative NMR is increased from tens to hundreds of kHz by a new pulse sequence, CHORUS. It uses chirp pulses to excite uniformly over very large bandwidths, yielding accurate integrals even for nuclei such as (19)F that have very wide spectra.

  4. Big Bandwidth Battle: Universal ADSL Looks Ahead.

    ERIC Educational Resources Information Center

    Hargadon, Tom

    1998-01-01

    Discusses the new Universal ADSL (Asymmetric Digital Subscriber Line) standard, which promises simple, high-bandwidth access over standard telephone lines. Topics include varieties of DSL; voice and data capacities; adapters and installation for personal computers; Internet backbone capacity; and headend access. (LRW)

  5. High bandwidth vapor density diagnostic system

    DOEpatents

    Globig, Michael A.; Story, Thomas W.

    1992-01-01

    A high bandwidth vapor density diagnostic system for measuring the density of an atomic vapor during one or more photoionization events. The system translates the measurements from a low frequency region to a high frequency, relatively noise-free region in the spectrum to provide improved signal to noise ratio.

  6. Design of the 1.5 MW, 30-96 MHz ultra-wideband 3 dB high power hybrid coupler for Ion Cyclotron Resonance Frequency (ICRF) heating in fusion grade reactor

    NASA Astrophysics Data System (ADS)

    Yadav, Rana Pratap; Kumar, Sunil; Kulkarni, S. V.

    2016-01-01

    Design and developmental procedure of strip-line based 1.5 MW, 30-96 MHz, ultra-wideband high power 3 dB hybrid coupler has been presented and its applicability in ion cyclotron resonance heating (ICRH) in tokamak is discussed. For the high power handling capability, spacing between conductors and ground need to very high. Hence other structural parameters like strip-width, strip thickness coupling gap, and junction also become large which can be gone upto optimum limit where various constrains like fabrication tolerance, discontinuities, and excitation of higher TE and TM modes become prominent and significantly deteriorates the desired parameters of the coupled lines system. In designed hybrid coupler, two 8.34 dB coupled lines are connected in tandem to get desired coupling of 3 dB and air is used as dielectric. The spacing between ground and conductors are taken as 0.164 m for 1.5 MW power handling capability. To have the desired spacing, each of 8.34 dB segments are designed with inner dimension of 3.6 × 1.0 × 40 cm where constraints have been significantly realized, compensated, and applied in designing of 1.5 MW hybrid coupler and presented in paper.

  7. Design of the 1.5 MW, 30-96 MHz ultra-wideband 3 dB high power hybrid coupler for Ion Cyclotron Resonance Frequency (ICRF) heating in fusion grade reactor.

    PubMed

    Yadav, Rana Pratap; Kumar, Sunil; Kulkarni, S V

    2016-01-01

    Design and developmental procedure of strip-line based 1.5 MW, 30-96 MHz, ultra-wideband high power 3 dB hybrid coupler has been presented and its applicability in ion cyclotron resonance heating (ICRH) in tokamak is discussed. For the high power handling capability, spacing between conductors and ground need to very high. Hence other structural parameters like strip-width, strip thickness coupling gap, and junction also become large which can be gone upto optimum limit where various constrains like fabrication tolerance, discontinuities, and excitation of higher TE and TM modes become prominent and significantly deteriorates the desired parameters of the coupled lines system. In designed hybrid coupler, two 8.34 dB coupled lines are connected in tandem to get desired coupling of 3 dB and air is used as dielectric. The spacing between ground and conductors are taken as 0.164 m for 1.5 MW power handling capability. To have the desired spacing, each of 8.34 dB segments are designed with inner dimension of 3.6 × 1.0 × 40 cm where constraints have been significantly realized, compensated, and applied in designing of 1.5 MW hybrid coupler and presented in paper.

  8. Combined use of lightweight magnetic Fe3O4-coated hollow glass spheres and electrically conductive reduced graphene oxide in an epoxy matrix for microwave absorption

    NASA Astrophysics Data System (ADS)

    Wang, Junpeng; Wang, Jun; Zhang, Bin; Sun, Yu; Chen, Wei; Wang, Tao

    2016-03-01

    Epoxy resin based lightweight composites comprising Fe3O4-coated hollow glass spheres (HGS@Fe3O4) and reduced graphene oxide (RGO) were prepared. Impedance matching condition and electromagnetic wave attenuation characteristic are used for analysis of the reflection loss (RL) performance of the composites. Compared with pure HGS@Fe3O4 and RGO composite, the -10 dB absorption bandwidth and the minimum RL of the hybrid composites are enhanced. RL values less than -10 dB are obtained in a wide frequency range and the corresponding bandwidth can reach up to 3.6 GHz when an appropriate absorber thickness is chosen. The density of the hybrid composite is in the range of 0.57-0.72 g/cm3, which is attractive candidate for a new type of lightweight microwave absorber.

  9. Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.

    PubMed

    Allen, H; Fraser, J; Flyer, D; Calvin, S; Flavell, R

    1986-10-01

    beta 2-Microglobulin (beta 2m) has been thought essential for transport of all major histocompatibility complex class I antigens to the cell surface. Here, we show that the mouse class I antigen H-2Db is expressed at the cell surface even when there is no beta 2m present within the cell. This was established by transfecting the H-2Db gene into the R1E cell line, which lacks beta 2m. The conformation of the Db antigen expressed by the R1E transfectant is very different from that of the native molecule. This Db antigen is not recognized by Db-allospecific and Db-restricted cytotoxic T lymphocytes or by most monoclonal antibodies to the native Db. We show further that a deletion construct of the Db gene, which consists of exon 1 linked to exons 4-8, expresses a truncated Db antigen lacking domains 1 and 2 [Db-(1 + 2)] at the cell surface after transfection into the R1E line. Previous biochemical and crystallographic data have indicated that domain 3 is associated with beta 2m; unexpectedly, Db-(1 + 2) does not associate with beta 2m when the mouse beta 2mb gene is transfected into the R1E transfectant expressing the truncated Db. This suggests that interactions with domains 1 and 2 are important for the paired association of domain 3 and beta 2m in the native Db antigen.

  10. CottonDB enhancement

    Technology Transfer Automated Retrieval System (TEKTRAN)

    CottonDB (www.cottondb.org) was initiated in 1995. It is a database that contains genomic, genetic, and taxonomic information for cotton (Gossypium spp.). It serves both as an archival database and as a dynamic database, which incorporates new data and user resources. CottonDB is maintained at th...

  11. Optimum design of wide-bandwidth, low-noise photodiode amplifiers. Volume 1: Bandwidth

    NASA Astrophysics Data System (ADS)

    Hamilton, D. K.

    A circuit with video applications was tested. A reversed biased junction is a parallel combination of resistance and capacitance, which varies with the applied reverse voltage. The complete equivalent circuit model includes these components in parallel with a current generator. For optimum response at high frequency critical damping is necessary. The circuit allows the use of an amplifier with a wider open loop bandwidth than one compensated for unity gain, with a corresponding increase in system bandwidth.

  12. Two compact preamps cover 38-GHz bandwidth

    NASA Astrophysics Data System (ADS)

    Osbrink, N. K.; Fake, S. R.; Rosenberg, J. C.

    1985-09-01

    The design and performance characteristics of two compact preamplifiers that provide complete coverage of the 2-18 and 18-40 GHz frequency bands are examined. The 2-18-GHz prototype amplifier consists of four stages of thin-film hybrid microwave integrated circuit (MIC) amplification modules each of which incorporates a single GaAs distributed microwave integrated circuit (MMIC). The amplifier weights about 2 ounces and measures 1.75 x 1.15 x 0.67 inches. The 18-40-GHz amplifier consists of five thin-film MIC balanced gain stages and a MIC voltage regulator module with a throughline. The amplifier displays worst-case noise figures of 11.6 dB at the low frequency end of the band and less than 8 dB over much of the band.

  13. Narrow-bandwidth unstable laser resonator

    SciTech Connect

    Reintjes, J.F.; Tankersley, L.L.; Cooper, D.

    1988-10-21

    The present invention relates to unstable laser resonators, particularly to unstable laser resonators, and particularly to an unstable laser resonator that produces optical radiation that simultaneously has the high output power diffraction-limited divergence characteristic of an unstable laser resonator and also the narrow bandwidth that can usually be obtained only with a stable laser resonator. Some success was achieved in the frequency narrowing of the laser radiation from an unstable laser resonator cavity by using a diffraction grating. This technique was works best with lasers that have sharp line structure, such as molecular lasers. For example, selection of a single line in a hydrogen-fluoride laser has been reported in several configurations involving the insertion of a diffraction grating into a standard unstable laser resonator cavity. Although currently available, unstable laser resonators have the configuration of choice for producing high-power, low-divergence radiation from laser cavities; they are not compatible with a simultaneous requirement of narrow bandwidth.

  14. High Bandwidth Differential Amplifier for Shock Experiments

    SciTech Connect

    Ross, P. W., Tran, V., Chau, R.

    2012-04-30

    We developed a high bandwidth differential amplifier for gas gun shock experiments/applications. The circuit has a bandwidth > 1 GHz, and is capable of measuring signals of ≤1.5 V with a common mode rejection of 250 V. Conductivity measurements of gas gun targets are measured by flowing high currents through the targets. The voltage is measured across the target using a technique similar to a four-point probe. Because of the design of the current source and load, the target voltage is approximately 250 V relative to ground. Since the expected voltage change in the target is < 1 V, the differential amplifier must have a large common mode rejection. High pass filters suppress internal ringing of operational amplifiers. Results of bench tests are shown.

  15. Soy Leaf Extract Containing Kaempferol Glycosides and Pheophorbides Improves Glucose Homeostasis by Enhancing Pancreatic β-Cell Function and Suppressing Hepatic Lipid Accumulation in db/db Mice.

    PubMed

    Li, Hua; Ji, Hyeon-Seon; Kang, Ji-Hyun; Shin, Dong-Ha; Park, Ho-Yong; Choi, Myung-Sook; Lee, Chul-Ho; Lee, In-Kyung; Yun, Bong-Sik; Jeong, Tae-Sook

    2015-08-19

    This study investigated the molecular mechanisms underlying the antidiabetic effect of an ethanol extract of soy leaves (ESL) in db/db mice. Control groups (db/+ and db/db) were fed a normal diet (ND), whereas the db/db-ESL group was fed ND with 1% ESL for 8 weeks. Dietary ESL improved glucose tolerance and lowered plasma glucose, glycated hemoglobin, HOMA-IR, and triglyceride levels. The pancreatic insulin content of the db/db-ESL group was significantly greater than that of the db/db group. ESL supplementation altered pancreatic IRS1, IRS2, Pdx1, Ngn3, Pax4, Ins1, Ins2, and FoxO1 expression. Furthermore, ESL suppressed lipid accumulation and increased glucokinase activity in the liver. ESL primarily contained kaempferol glycosides and pheophorbides. Kaempferol, an aglycone of kaempferol glycosides, improved β-cell proliferation through IRS2-related FoxO1 signaling, whereas pheophorbide a, a product of chlorophyll breakdown, improved insulin secretion and β-cell proliferation through IRS1-related signaling with protein kinase A in MIN6 cells. ESL effectively regulates glucose homeostasis by enhancing IRS-mediated β-cell insulin signaling and suppressing SREBP-1-mediated hepatic lipid accumulation in db/db mice. PMID:26211813

  16. Soy Leaf Extract Containing Kaempferol Glycosides and Pheophorbides Improves Glucose Homeostasis by Enhancing Pancreatic β-Cell Function and Suppressing Hepatic Lipid Accumulation in db/db Mice.

    PubMed

    Li, Hua; Ji, Hyeon-Seon; Kang, Ji-Hyun; Shin, Dong-Ha; Park, Ho-Yong; Choi, Myung-Sook; Lee, Chul-Ho; Lee, In-Kyung; Yun, Bong-Sik; Jeong, Tae-Sook

    2015-08-19

    This study investigated the molecular mechanisms underlying the antidiabetic effect of an ethanol extract of soy leaves (ESL) in db/db mice. Control groups (db/+ and db/db) were fed a normal diet (ND), whereas the db/db-ESL group was fed ND with 1% ESL for 8 weeks. Dietary ESL improved glucose tolerance and lowered plasma glucose, glycated hemoglobin, HOMA-IR, and triglyceride levels. The pancreatic insulin content of the db/db-ESL group was significantly greater than that of the db/db group. ESL supplementation altered pancreatic IRS1, IRS2, Pdx1, Ngn3, Pax4, Ins1, Ins2, and FoxO1 expression. Furthermore, ESL suppressed lipid accumulation and increased glucokinase activity in the liver. ESL primarily contained kaempferol glycosides and pheophorbides. Kaempferol, an aglycone of kaempferol glycosides, improved β-cell proliferation through IRS2-related FoxO1 signaling, whereas pheophorbide a, a product of chlorophyll breakdown, improved insulin secretion and β-cell proliferation through IRS1-related signaling with protein kinase A in MIN6 cells. ESL effectively regulates glucose homeostasis by enhancing IRS-mediated β-cell insulin signaling and suppressing SREBP-1-mediated hepatic lipid accumulation in db/db mice.

  17. A frequency and bandwidth tunable metamaterial absorber in x-band

    NASA Astrophysics Data System (ADS)

    Yuan, H.; Zhu, B. O.; Feng, Y.

    2015-05-01

    Smart control is an attracting and important function for modern electromagnetic wave absorber. This paper presents the design, fabrication, and measurement of a frequency and bandwidth tunable metamaterial absorber (MA) in X-band. The unit cell of the MA consists of a microstrip resonator loaded with the varactors. Simulation and measurement results show that by tuning the bias voltage on the varactors, the peak absorption frequency can be tuned by 0.44 GHz with the peak absorption greater than 95%. Field and circuit model analysis is conducted to reveal the working mode and predict the absorbing frequency. After that, by specially designing the bias circuit so as to adjust the bias voltage on neighboring unit cells separately, dual resonance and absorption peaks occur, and the overall absorption bandwidth can thus be tuned conveniently by controlling the difference of the two resonance frequencies. The center absorbing frequency can also be tuned. Simulation and experiment results show that the 75% absorption (-6 dB reflection) bandwidth can be tuned from 0.40 GHz to 0.74 GHz, which is a two-fold tuning range. This work is believed to improve the state-of-the-art smart metamaterial absorber.

  18. Wide-frequency-bandwidth whisker-inspired MEMS vector hydrophone encapsulated with parylene

    NASA Astrophysics Data System (ADS)

    Wang, Renxin; Liu, Yuan; Bai, Bing; Guo, Nan; Guo, Jing; Wang, Xubo; Liu, Mengran; Zhang, Guojun; Zhang, Binzhen; Xue, Chenyang; Liu, Jun; Zhang, Wendong

    2016-02-01

    In order to eliminate polyurethane hat resonance frequency intervention and reduce fluid influence, a whisker-inspired MEMS vector hydrophone (WIVH) encapsulated with parylene is proposed to broaden frequency bandwidth and improve sensitivity-frequency response performance, compared to the lateral line-inspired MEMS vector hydrophone (LLIVH). Parylene that is conformally deposited on the device surface replaces polyurethane encapsulating hat and silicone oil existing in current encapsulation technology. The main advantage of WIVH as demonstrated by modelling and characterization is the enhanced bandwidth response, which is the critical factor in hydrophone design. Acoustic pressure gradient properties of the WIVH and LLIVH are analyzed to demonstrate the influence of the polyurethane hat. The interactions of the parylene membrane with fluid and the influences on vibrating performance are also investigated. Resonance measurement and sensitivity-frequency response analysis demonstrate the frequency bandwidth of the WIVH could be extended twice compared to that of the LLIVH. Moreover, the WIVH is proved to act as a typical pressure gradient hydrophone with an increment of 6 dB per octave in the linear region.

  19. Design of wide bandwidth pyramidal microwave absorbers using ferrite composites with broad magnetic loss spectra

    NASA Astrophysics Data System (ADS)

    Park, Myung-Jun; Kim, Sung-Soo

    2016-09-01

    Wide bandwidth microwave absorbers with a pyramidal shape and a significantly reduced thickness can be designed using high lossy ferrite materials with broad magnetic loss spectra. The microwave absorbing properties of pyramidal cone absorbers are analyzed using the transmission line approximation, which provides the reflection loss as a function of the material parameters and absorber geometry. Three types of ferrite materials (NiZn spinel ferrite, Co2Z hexaferrite, and RuCoM hexaferrite) are used as the absorbent fillers in a rubber matrix. Among these, Co2Z ferrite is the most suitable material for wide bandwidth pyramidal absorbers, due to its broad magnetic loss spectrum in the GHz frequency range. The optimal geometry of the pyramidal absorber is also determined using the transmission line theory. With the reduced total height of the pyramidal absorber (approximately 60 mm), a wide bandwidth (1.5-18 GHz with respect to the -20 dB reflection loss) can be realized. The proposed absorbers have a thickness advantage over the classical pyramidal ohmic absorbers; thus, they are suitable for small and semi-anechoic chambers.

  20. Design of wide bandwidth pyramidal microwave absorbers using ferrite composites with broad magnetic loss spectra

    NASA Astrophysics Data System (ADS)

    Park, Myung-Jun; Kim, Sung-Soo

    2016-07-01

    Wide bandwidth microwave absorbers with a pyramidal shape and a significantly reduced thickness can be designed using high lossy ferrite materials with broad magnetic loss spectra. The microwave absorbing properties of pyramidal cone absorbers are analyzed using the transmission line approximation, which provides the reflection loss as a function of the material parameters and absorber geometry. Three types of ferrite materials (NiZn spinel ferrite, Co2Z hexaferrite, and RuCoM hexaferrite) are used as the absorbent fillers in a rubber matrix. Among these, Co2Z ferrite is the most suitable material for wide bandwidth pyramidal absorbers, due to its broad magnetic loss spectrum in the GHz frequency range. The optimal geometry of the pyramidal absorber is also determined using the transmission line theory. With the reduced total height of the pyramidal absorber (approximately 60 mm), a wide bandwidth (1.5-18 GHz with respect to the -20 dB reflection loss) can be realized. The proposed absorbers have a thickness advantage over the classical pyramidal ohmic absorbers; thus, they are suitable for small and semi-anechoic chambers.

  1. Bandwidth Enhancement of Cylindrical Dielectric Resonator Antenna Using Thin Dielectric Layer Fed by Resonating Slot

    NASA Astrophysics Data System (ADS)

    Mishra, Nipun K.; Das, Soma; Vishwakarma, Dinesh K.

    2016-09-01

    In this paper Cylindrical Dielectric Resonator Antenna (CDRA) has been designed for X-band frequency range applications with slot feeding. Bandwidth of designed cylindrical dielectric resonator antenna has been enhanced by making the slot to be resonating and inserting very thin low permittivity dielectric layer between the slot and CDRA. Resonating slot excites the closely spaced HEM11δ and HEM21δ mode inside the antenna as well as provides the resonance at the upper side of desired X-band. Low profile low permittivity layer provides the excellent matching of these modes and shift the HEM21δ mode to higher frequency side at 11.25 GHz with better impedance matching. By combining all of three resonances, nearly 85 % increment in impedance Bandwidth has been obtained with reference to non resonating slot excited CDRA. Fractional impedance bandwidth for proposed design is 48 % and average Gain of 6 dB with more than 92 % radiation efficiency has been shown by the antenna throughout the desired band with broadside pattern.

  2. Role of Bandwidth in Computation of NDVI From Landsat TM and NOAA AVHRR Bands

    NASA Astrophysics Data System (ADS)

    Gupta, R. K.; Vijayan, D.; Prasad, T. S.; Tirumaladevi, N. Ch.

    The observations for wheat, onion, potato and chickpea over the Crop Growth Cycle (CGC) in 3 nm bandwidth were converted to AVHRR and TM bands in visible/red and near-IR spectral regions. Correlation between TM and AVHRR NDVI were very high for all these crops. The additional 0.725-0.76 μm bandwidth in AVHRR as compared to TM was causing reduction in NDVI values for AVHRR when crop NDVI value was more than 0.46

  3. 47 CFR 2.1049 - Measurements required: Occupied bandwidth.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Measurements required: Occupied bandwidth. 2.1049 Section 2.1049 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY ALLOCATIONS... Certification § 2.1049 Measurements required: Occupied bandwidth. The occupied bandwidth, that is the...

  4. Reno-protection of G004, a novel anti-diabetic sulfonylurea in db/db mice.

    PubMed

    Tong, Xiaohui; Ma, Haijian; Amadi, Sarah Wambui; Ma, Lingman; Wu, Guanzhong

    2015-08-01

    1-[4-[2-(4-Bromobenzene-sulfonamino)ethyl]phenylsulfonyl]-3-(trans-4-methylcyclohexyl) urea (G004, CAS865483-06-3) is a synthetic sulfonylurea, incorporating the hypoglycemic active structure of glimepiride (CAS 93479-97-1) and anti-TXA2 receptor (TP) active structure of BM-531(CAS 284464-46-6). In this study, we evaluated the effect of G004 on hyperglycemia and dyslipidemia as well as diabetic nephropathy (DN) in db/db mice by gavage over 90 consecutive days of treatment. The fasting blood glucose (FBG), glucose, and insulin tolerance as well as dyslipidemia were effectively ameliorated in db/db mice treated with G004. Interestingly, renal histological results of db/db mice revealed that G004 markedly reversed the expansion of mesangial extracellular matrix (ECM), the early hallmark of DN. Indeed, G004 treatment downregulated the renal expressions of type 4 collagen (Col IV) and transforming growth factor-β1 (TGF-β1) in db/db mice. In addition, imbalance in expressions of matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor-1 (TIMP-1) in db/db mice kidneys was observed. However, G004 increased and decreased the expressions of MMP-9 and TIMP-1, respectively. It is well known that TGF-β pathway signaling plays an essential role in hyperglycemia-induced cell protein synthesis. On the other hand, MMP/TIMP system is responsible for the breakdown and turnover of ECM. Thus, we speculate that G004 possibly attenuated ECM accumulation via remodeling the synthesis and degradation of ECM component Col IV through modulation in TGF-β1 and MMP-9/TIMP-1 expressions in kidneys of db/db mice. Results from this study provide a strong rationale for G004 to be an efficient glucose-controlling agent with significant reno-protective properties. PMID:25943026

  5. Generation of large-bandwidth x-ray free-electron-laser pulses

    NASA Astrophysics Data System (ADS)

    Saa Hernandez, Angela; Prat, Eduard; Bettoni, Simona; Beutner, Bolko; Reiche, Sven

    2016-09-01

    X-ray free-electron lasers (XFELs) are modern research tools in disciplines such as biology, material science, chemistry, and physics. Besides the standard operation that aims at minimizing the bandwidth of the produced XFEL radiation, there is a strong scientific demand to produce large-bandwidth XFEL pulses for several applications such as nanocrystallography, stimulated Raman spectroscopy, and multiwavelength anomalous diffraction. We present a self-consistent method that maximizes the XFEL pulse bandwidth by systematically maximizing the energy chirp of the electron beam at the undulator entrance. This is achieved by optimizing the compression scheme and the electron distribution at the source in an iterative back-and-forward tracking. Start-to-end numerical simulations show that a relative bandwidth of 3.25% full-width can be achieved for the hard x-ray pulses in the SwissFEL case.

  6. Spiral amplifiers in a-Al2O3:Er on a silicon chip with 20 dB internal net gain

    NASA Astrophysics Data System (ADS)

    Vázquez-Córdova, S. A.; Bernhardi, E. H.; Wörhoff, Ke.; Herek, J. L.; García-Blanco, S. M.; Pollnau, M.

    2015-02-01

    Spiral-waveguide amplifiers in erbium-doped amorphous aluminum oxide are fabricated by RF reactive co-sputtering of 1-μm-thick layers onto a thermally-oxidized silicon wafer and chlorine-based reactive ion etching. The samples are overgrown by a SiO2 cladding. Spirals with several lengths ranging from 13 cm to 42 cm and four different erbium concentrations between 0.5-3.0×1020 cm-3 are experimentally characterized. A maximum internal net gain of 20 dB in the small-signal-gain regime is measured at the peak emission wavelength of 1532 nm for two sample configurations with waveguide lengths of 13 cm and 24 cm and erbium concentrations of 2×1020 cm-3 and 1×1020 cm-3, respectively. The obtained gain improves previous results by van den Hoven et al. in this host material by a factor of 9. Gain saturation as a result of increasing signal power is investigated. Positive net gain is measured in the saturated-gain regime up to ~100 μW of signal power, but extension to the mW regime seems feasible. The experimental results are compared to a rate-equation model that takes into account migration-accelerated energy-transfer upconversion (ETU) and a fast quenching process affecting a fraction of the erbium ions. Without these two detrimental processes, several tens of dB/cm of internal net gain per unit length would be achievable. Whereas ETU limits the gain per unit length to 8 dB/cm, the fast quenching process further reduces it to 2 dB/cm. The fast quenching process strongly deteriorates the amplifier performance of the Al2O3:Er3+ waveguide amplifiers. This effect is accentuated for concentrations higher than 2×1020 cm-3.

  7. Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice.

    PubMed

    Winzell, Maria Sörhede; Wulff, Erik Max; Olsen, Grith Skytte; Sauerberg, Per; Gotfredsen, Carsten F; Ahrén, Bo

    2010-01-25

    The peroxisome proliferator-activated receptors (PPARs) are transcription factors belonging to the nuclear receptor superfamily. Several reports have shown that PPARdelta is involved in lipid metabolism, increasing fat oxidation and depleting lipid accumulation. Whether PPARdelta is involved in the regulation of glucose metabolism is not completely understood. In this study, we examined effects of long-term PPARdelta activation on glycemic control, islet function and insulin sensitivity in diabetic db/db mice. Male db/db mice were administered orally once daily with a selective and partial PPARdelta agonist (NNC 61-5920, 30 mg/kg) for eight weeks; control mice received vehicle. Fasting and non-fasting plasma glucose were reduced, reflected in reduced hemoglobinA(1c) (3.6+/-1.6% vs. 5.4+/-1.8 in db/db controls, P<0.05) and furthermore, the AUC(glucose) after oral glucose (3g/kg) was reduced by 67% (P<0.05) after long-term PPARdelta activation. Following intravenous glucose (1g/kg), glucose tolerance was improved after PPARdelta activation (K(G) 1.3+/-0.6 vs. -0.05+/-0.7 %/min, P=0.048). Insulin sensitivity, measured as the glucose clearance after intravenous injection of glucose (1g/kg) and insulin (0.75 or 1.0 U/kg), during inhibition of endogenous insulin secretion by diazoxide (25mg/kg), was improved (K(G) 2.9+/-0.6 vs. 1.3+/-0.3 %/min in controls, P<0.05) despite lower insulin levels. Furthermore, islets isolated from PPARdelta agonist treated mice demonstrated improved glucose responsiveness as well as improved cellular topography. In conclusion, PPARdelta agonism alleviates insulin resistance and improves islet function and topography, resulting in improved glycemia in diabetic db/db mice. This suggests that activation of PPARdelta improves glucose metabolism and may therefore potentially be target for treatment of type 2 diabetes.

  8. 47 CFR 101.109 - Bandwidth.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., consistent with efficient use of the spectrum and good engineering practice, except that Type B, damped-wave... communications. Frequency band (MHz) Maximum authorized bandwidth 928 to 929 25 kHz 1,5,6 932 to 932.5, 941 to 941.5 12.5 kHz 1,5,6 932.5 to 935, 941.5 to 944 200 kHz 1 952 to 960 200 KHz 1,5,6 1,850 to 1,990...

  9. Confocal microscopy via multimode fibers: fluorescence bandwidth

    NASA Astrophysics Data System (ADS)

    Loterie, Damien; Psaltis, Demetri; Moser, Christophe

    2016-03-01

    We recently described a method for confocal reflection imaging through fibers, as a way to increase contrast when imaging unstained biological specimens. Using a transmission matrix, focused spots can be created at the distal end of a fiber. The backscattered field coming back from the sample can be filtered using optical correlation to obtain spatial selectivity in the detection. In this proceedings article, we briefly review the working principle of this method, and we discuss how the scheme could be adapted to confocal fluorescence imaging. In particular, we show simulations of the achievable detection bandwidth when using step-index multimode fibers as imaging devices.

  10. Variable bandwidth broadcasting protocol for video-on-demand

    NASA Astrophysics Data System (ADS)

    Paris, Jehan-Francois; Long, Darrell D. E.

    2003-01-01

    We present the first broadcasting protocol that can alter the number of channels allocated to a given video without inconveniencing the viewer and without causing any temporary bandwidth surge. Our variable bandwidth broadcasting (VBB) protocol assigns to each video a minimum number of channels whose bandwidths are all equal to the video consumption rate. Additional channels can be assigned to the video at any time to reduce the customer waiting time or retaken to free server bandwidth. The cost of this additional flexibility is quite reasonable as the bandwidth requirements of our VBB fall between those of the fast broadcasting protocol and the new pagoda broadcasting protocol.

  11. An exponential time 2-approximation algorithm for bandwidth

    SciTech Connect

    Kasiviswanathan, Shiva; Furer, Martin; Gaspers, Serge

    2009-01-01

    The bandwidth of a graph G on n vertices is the minimum b such that the vertices of G can be labeled from 1 to n such that the labels of every pair of adjacent vertices differ by at most b. In this paper, we present a 2-approximation algorithm for the Bandwidth problem that takes worst-case {Omicron}(1.9797{sup n}) = {Omicron}(3{sup 0.6217n}) time and uses polynomial space. This improves both the previous best 2- and 3-approximation algorithms of Cygan et al. which have an {Omicron}*(3{sup n}) and {Omicron}*(2{sup n}) worst-case time bounds, respectively. Our algorithm is based on constructing bucket decompositions of the input graph. A bucket decomposition partitions the vertex set of a graph into ordered sets (called buckets) of (almost) equal sizes such that all edges are either incident on vertices in the same bucket or on vertices in two consecutive buckets. The idea is to find the smallest bucket size for which there exists a bucket decomposition. The algorithm uses a simple divide-and-conquer strategy along with dynamic programming to achieve this improved time bound.

  12. Tunable pulsed narrow bandwidth light source

    DOEpatents

    Powers, Peter E.; Kulp, Thomas J.

    2002-01-01

    A tunable pulsed narrow bandwidth light source and a method of operating a light source are provided. The light source includes a pump laser, first and second non-linear optical crystals, a tunable filter, and light pulse directing optics. The method includes the steps of operating the pump laser to generate a pulsed pump beam characterized by a nanosecond pulse duration and arranging the light pulse directing optics so as to (i) split the pulsed pump beam into primary and secondary pump beams; (ii) direct the primary pump beam through an input face of the first non-linear optical crystal such that a primary output beam exits from an output face of the first non-linear optical crystal; (iii) direct the primary output beam through the tunable filter to generate a sculpted seed beam; and direct the sculpted seed beam and the secondary pump beam through an input face of the second non-linear optical crystal such that a secondary output beam characterized by at least one spectral bandwidth on the order of about 0.1 cm.sup.-1 and below exits from an output face of the second non-linear optical crystal.

  13. Coherence bandwidth loss in transionospheric radio propagation

    NASA Technical Reports Server (NTRS)

    Rino, C. L.; Gonzalez, V. H.; Hessing, A. R.

    1980-01-01

    In this report a theoretical model is developed that predicts the single-point, two-frequency coherence function for transionospheric radio waves. The theoretical model is compared to measured complex frequency correlation coefficients using data from the seven equispaced, phase-coherent UHF signals transmitted by the Wideband satellite. The theory and data are in excellent agreement. The theory is critically dependent upon the power-law index, and the frequency coherence data clearly favor the comparatively small spectral indices that have been consistently measured from the wideband satellite phase data. A model for estimating the pulse delay jitter induced by the coherence bandwidth loss is also developed and compared with the actual delay jitter observed on synthesized pulses obtained from the Wideband UFH comb. The results are in good agreement with the theory. The results presented in this report, which are based on an asymptotic theory, are compared with the more commonly used quadratic theory. The model developed and validated in this report can be used to predict the effects of coherence bandwidth loss in disturbed nuclear environments. Simple formulas for the resultant pulse delay jitter are derived that can be used in predictive codes.

  14. Spin-torque diode with tunable sensitivity and bandwidth by out-of-plane magnetic field

    NASA Astrophysics Data System (ADS)

    Li, X.; Zheng, C.; Zhou, Y.; Kubota, H.; Yuasa, S.; Pong, Philip W. T.

    2016-06-01

    Spin-torque diodes based on nanosized magnetic tunnel junctions are novel microwave detectors with high sensitivity and wide frequency bandwidth. While previous reports mainly focus on improving the sensitivity, the approaches to extend the bandwidth are limited. This work experimentally demonstrates that through optimizing the orientation of the external magnetic field, wide bandwidth can be achieved while maintaining high sensitivity. The mechanism of the frequency- and sensitivity-tuning is investigated through analyzing the dependence of resonant frequency and DC voltage on the magnitude and the tilt angle of hard-plane magnetic field. The frequency dependence is qualitatively explicated by Kittel's ferromagnetic resonance model. The asymmetric resonant frequency at positive and negative magnetic field is verified by the numerical simulation considering the in-plane anisotropy. The DC voltage dependence is interpreted through evaluating the misalignment angle between the magnetization of the free layer and the reference layer. The tunability of the detector performance by the magnetic field angle is evaluated through characterizing the sensitivity and bandwidth under 3D magnetic field. The frequency bandwidth up to 9.8 GHz or maximum sensitivity up to 154 mV/mW (after impedance mismatch correction) can be achieved by tuning the angle of the applied magnetic field. The results show that the bandwidth and sensitivity can be controlled and adjusted through optimizing the orientation of the magnetic field for various applications and requirements.

  15. Dietary Black Raspberry Seed Oil Ameliorates Inflammatory Activities in db/db Mice.

    PubMed

    Lee, Hee Jae; Jung, Hana; Cho, Hyunnho; Lee, Kiuk; Kwak, Ho-Kyung; Hwang, Keum Taek

    2016-06-01

    The objective of this study was to evaluate the status of the markers related to inflammation in db/db mice fed black raspberry seed (BRS) oil, which is rich in α-linolenic acid. Mice were divided into four groups: (1) C57BL/6 mice fed 16 % calories from soybean oil (normal CON); (2) C57BL/KsJ-db/db mice fed 16 % calories from soybean oil (CON); (3) C57BL/KsJ-db/db mice fed 8 % calories from soybean and 8 % calories from BRS oil (BRS 50 %); and (4) C57BL/KsJ-db/db mice fed 16 % calories from BRS oil (BRS 100 %). After 10 weeks, n-6/n-3 fatty acid ratios were significantly (P < 0.05) lower in the livers and epididymal adipose tissues of the BRS 50 % and BRS 100 % mice than in the CON. Serum TNFα and IL-6 were significantly (P < 0.05) lower in the BRS 50 % and BRS 100 % than in the CON. Serum IL-10 was significantly (P < 0.05) higher in the BRS 100 % than the CON. In the liver and epididymal adipose tissue, mRNA levels of pro-inflammatory markers in the BRS 50 % and BRS 100 % were lower than in the CON. Anti-inflammatory markers were higher in the epididymal adipose tissues of the BRS 50 % and BRS 100 % than in the CON. In the epididymal adipose tissue, macrophage infiltration markers (F4/80 and CD68) and leptin mRNA were significantly (P < 0.05) lower in the BRS 50 % and BRS 100 % than in the CON. Results of this study suggest that BRS oil may have anti-inflammatory effects in obese diabetic mice by ameliorating inflammatory responses. PMID:27165261

  16. High power fiber MOPA based QCW laser delivering pulses with arbitrary duration on demand at high modulation bandwidth.

    PubMed

    Petkovšek, Rok; Novak, Vid; Agrež, Vid

    2015-12-28

    We report on a concept of a fiber MOPA based quasi-CW laser working at high modulation bandwidths up to 40 MHz capable of producing arbitrary pulse durations at arbitrary repetition rates. An output power of over 100 W was achieved and an on-off contrast of 25 dB. The laser features a dual-channel (dual-wavelength) seed source, a double stage YDF amplifier and a volume-Bragg-grating-based signal de-multiplexer. Minimization of transients was conducted through experiment and model analysis. PMID:26831982

  17. Neurobehavioral deficits in db/db diabetic mice

    PubMed Central

    Sharma, Ajaykumar N.; Elased, Khalid M.; Garrett, Teresa L.; Lucot, James B.

    2011-01-01

    Recent clinical studies indicate neurobehavioral disturbances in type-2 diabetics. However, there is paucity of preclinical research to support this concept. The validity of db/db mouse as an animal model to study type-2 diabetes and related complications is known. The present study was designed to investigate comprehensively the db/db mouse behavior as preclinical evidence of type-2 diabetes related major neurobehavioral complications. We tested juvenile (5–6 weeks) and adult (10–11 weeks) db/db mice for behavioral depression in forced swim test (FST), psychosis-like symptoms using pre-pulse inhibition (PPI) test, anxiety behavior employing elevated plus maze (EPM) test, locomotor behavior and thigmotaxis using open field test and working memory deficits in Y-maze test. Both juvenile and adult group db/db mice displayed behavioral despair with increased immobility time in FST. There was an age-dependent progression of psychosis-like symptoms with disrupted PPI in adult db/db mice. In the EPM test, db/db mice were less anxious as observed by increased percent open arms time and entries. They were also hypolocomotive as evident by a decrease in their basic and fine movements. There was no impairment of working memory in the Y-maze test in db/db mice. This is the first report of depression, psychosis-like symptoms and anxiolytic behavior of db/db mouse strain. It is tempting to speculate that this mouse strain can serve as useful preclinical model to study type-2 diabetes related neurobehavioral complications. PMID:20637218

  18. Tb/s physical random bit generation with bandwidth-enhanced chaos in three-cascaded semiconductor lasers.

    PubMed

    Sakuraba, Ryohsuke; Iwakawa, Kento; Kanno, Kazutaka; Uchida, Atsushi

    2015-01-26

    We experimentally demonstrate fast physical random bit generation from bandwidth-enhanced chaos by using three-cascaded semiconductor lasers. The bandwidth-enhanced chaos is obtained with the standard bandwidth of 35.2 GHz, the effective bandwidth of 26.0 GHz and the flatness of 5.6 dB, whose waveform is used for random bit generation. Two schemes of single-bit and multi-bit extraction methods for random bit generation are carried out to evaluate the entropy rate and the maximum random bit generation rate. For single-bit generation, the generation rate at 20 Gb/s is obtained for physical random bit sequences. For multi-bit generation, the maximum generation rate at 1.2 Tb/s ( = 100 GS/s × 6 bits × 2 data) is equivalently achieved for physical random bit sequences whose randomness is verified by using both NIST Special Publication 800-22 and TestU01.

  19. PEP Deployment and Bandwidth Management Issues

    NASA Astrophysics Data System (ADS)

    Younghusband, Charles; Slade, Peter; Weaver, Jeff

    This paper will discuss current deployment scenarios for Performance Enhancement Proxies (PEP) technologies in broadband satellite access systems from the perspective of one PEP technology provider. Recent improvements such as DVB-S2 can provide substantial gains at the link layer. In order to achieve further efficiency gains, the satellite industry is now forced to look elsewhere - namely other layers in the data communications network stack. Satellite terminal manufacturers are now moving beyond basic TCP acceleration techniques to more comprehensive optimization techniques that incorporate advances in data compression and flexibility for more deployment scenarios. Some of the advances for PEP technology are in part due to CPU and memory technology advances, resulting in increasingly affordable access to computing power, allowing PEP manufacturers deliver substantial performance and bandwidth savings gains.

  20. High bandwidth magnetically isolated signal transmission circuit

    NASA Technical Reports Server (NTRS)

    Repp, John Donald (Inventor)

    2005-01-01

    Many current electronic systems incorporate expensive or sensitive electrical components. Because electrical energy is often generated or transmitted at high voltages, the power supplies to these electronic systems must be carefully designed. Power supply design must ensure that the electrical system being supplied with power is not exposed to excessive voltages or currents. In order to isolate power supplies from electrical equipment, many methods have been employed. These methods typically involve control systems or signal transfer methods. However, these methods are not always suitable because of their drawbacks. The present invention relates to transmitting information across an interface. More specifically, the present invention provides an apparatus for transmitting both AC and DC information across a high bandwidth magnetic interface with low distortion.

  1. A high-bandwidth spintronic position sensor.

    PubMed

    Tuma, Tomas; Pantazi, Angeliki; Sahoo, Deepak R; Eib, Philipp; Salis, Gian; Pozidis, Haris; Sebastian, Abu

    2014-09-19

    Position sensing with resolution down to the scale of a single atom is of key importance in nanoscale science and engineering. However, only optical-sensing methods are currently capable of non-contact sensing at such resolution over a high bandwidth. Here, we report a new non-contact, non-optical position-sensing concept based on detecting changes in a high-gradient magnetic field of a microscale magnetic dipole by means of spintronic sensors. Experimental measurements show a sensitivity of up to 40 Ω/μm, a linear range greater than 10 μm and a noise floor of 0.5 pm/√[Hz]. Also shown is the use of the sensor for position measurements for closed-loop control of a high-speed atomic force microscope with a frame rate of more than 1 frame/s.

  2. Optimal filter bandwidth for pulse oximetry

    NASA Astrophysics Data System (ADS)

    Stuban, Norbert; Niwayama, Masatsugu

    2012-10-01

    Pulse oximeters contain one or more signal filtering stages between the photodiode and microcontroller. These filters are responsible for removing the noise while retaining the useful frequency components of the signal, thus improving the signal-to-noise ratio. The corner frequencies of these filters affect not only the noise level, but also the shape of the pulse signal. Narrow filter bandwidth effectively suppresses the noise; however, at the same time, it distorts the useful signal components by decreasing the harmonic content. In this paper, we investigated the influence of the filter bandwidth on the accuracy of pulse oximeters. We used a pulse oximeter tester device to produce stable, repetitive pulse waves with digitally adjustable R ratio and heart rate. We built a pulse oximeter and attached it to the tester device. The pulse oximeter digitized the current of its photodiode directly, without any analog signal conditioning. We varied the corner frequency of the low-pass filter in the pulse oximeter in the range of 0.66-15 Hz by software. For the tester device, the R ratio was set to R = 1.00, and the R ratio deviation measured by the pulse oximeter was monitored as a function of the corner frequency of the low-pass filter. The results revealed that lowering the corner frequency of the low-pass filter did not decrease the accuracy of the oxygen level measurements. The lowest possible value of the corner frequency of the low-pass filter is the fundamental frequency of the pulse signal. We concluded that the harmonics of the pulse signal do not contribute to the accuracy of pulse oximetry. The results achieved by the pulse oximeter tester were verified by human experiments, performed on five healthy subjects. The results of the human measurements confirmed that filtering out the harmonics of the pulse signal does not degrade the accuracy of pulse oximetry.

  3. Novel high-bandwidth bimorph deformable mirrors

    NASA Astrophysics Data System (ADS)

    Griffith, Michael S.; Laycock, Leslie C.; Archer, Nick J.

    2004-12-01

    Adaptive Optics (AO) is a critical underpinning technology for future laser delivery (including free-space optical communications), target illumination and imaging systems. It measures and compensates for optical distortion caused by transmission through the atmosphere, resulting in the ability to deploy smaller lasers and identify targets at greater ranges. One of the key components in an AO system is the wavefront modifier, which acts on the incoming or outgoing beam to counter the effects of the atmosphere. BAE SYSTEMS Advanced Technology Centre is developing multi-element bimorph deformable mirrors for such an applications. Our initial designs were based on a standard construction and exhibited a resonant frequency of 1kHz with a maximum stroke of +/-20μm for an active aperture of 50mm. These devices were limited by the necessity to have a 'dead space' between the inner active area and the mirror boundary; this ensured that both the requirements for the stroke and the fixed boundary conditions could be met simultaneously. However, there was a significant penalty to pay in terms of bandwidth, which is inversely proportional to the square of the full mirror diameter. In a series of iteration steps, we have created novel mounting arrangements that reduce dead space and thus provide the optimum trade-off between bandwidth and stroke. These schemes include supporting the mirror from underneath, rather than at its edge. As a result, models of 60mm active diameter mirrors predict a resonance in excess of 5kHz, combined with a maximum stroke greater than +/-40μm. This paper will discuss a number of different mirror designs and present experimental results for recently assembled devices.

  4. Optimal filter bandwidth for pulse oximetry.

    PubMed

    Stuban, Norbert; Niwayama, Masatsugu

    2012-10-01

    Pulse oximeters contain one or more signal filtering stages between the photodiode and microcontroller. These filters are responsible for removing the noise while retaining the useful frequency components of the signal, thus improving the signal-to-noise ratio. The corner frequencies of these filters affect not only the noise level, but also the shape of the pulse signal. Narrow filter bandwidth effectively suppresses the noise; however, at the same time, it distorts the useful signal components by decreasing the harmonic content. In this paper, we investigated the influence of the filter bandwidth on the accuracy of pulse oximeters. We used a pulse oximeter tester device to produce stable, repetitive pulse waves with digitally adjustable R ratio and heart rate. We built a pulse oximeter and attached it to the tester device. The pulse oximeter digitized the current of its photodiode directly, without any analog signal conditioning. We varied the corner frequency of the low-pass filter in the pulse oximeter in the range of 0.66-15 Hz by software. For the tester device, the R ratio was set to R = 1.00, and the R ratio deviation measured by the pulse oximeter was monitored as a function of the corner frequency of the low-pass filter. The results revealed that lowering the corner frequency of the low-pass filter did not decrease the accuracy of the oxygen level measurements. The lowest possible value of the corner frequency of the low-pass filter is the fundamental frequency of the pulse signal. We concluded that the harmonics of the pulse signal do not contribute to the accuracy of pulse oximetry. The results achieved by the pulse oximeter tester were verified by human experiments, performed on five healthy subjects. The results of the human measurements confirmed that filtering out the harmonics of the pulse signal does not degrade the accuracy of pulse oximetry.

  5. The Effect of Pulse Shaping QPSK on Bandwidth Efficiency

    NASA Technical Reports Server (NTRS)

    Purba, Josua Bisuk Mubyarto; Horan, Shelia

    1997-01-01

    This research investigates the effect of pulse shaping QPSK on bandwidth efficiency over a non-linear channel. This investigation will include software simulations and the hardware implementation. Three kinds of filters: the 5th order Butterworth filter, the 3rd order Bessel filter and the Square Root Raised Cosine filter with a roll off factor (alpha) of 0.25,0.5 and 1, have been investigated as pulse shaping filters. Two different high power amplifiers, one a Traveling Wave Tube Amplifier (TWTA) and the other a Solid State Power Amplifier (SSPA) have been investigated in the hardware implementation. A significant improvement in the bandwidth utilization (rho) for the filtered data compared to unfiltered data through the non-linear channel is shown in the results. This method promises strong performance gains in a bandlimited channel when compared to unfiltered systems. This work was conducted at NMSU in the Center for Space Telemetering, and Telecommunications Systems in the Klipsch School of Electrical and Computer Engineering Department and is supported by a grant from the National Aeronautics and Space Administration (NASA) NAG5-1491.

  6. Size-Controllable Synthesis of Fe3O4 Nanospheres for Electromagnetic Wave Absorber

    NASA Astrophysics Data System (ADS)

    Wang, Yanping; Sun, Danping; Liu, Gongzong; Wang, Yujiao; Jiang, Wei

    2015-07-01

    We present a hydrothermal method to control the size of Fe3O4 nanospheres by adjusting the concentration of FeCl3·6H2O in ethylene glycol/diethylene glycol binary solvent mixtures. The electromagnetic wave absorption properties of Fe3O4 nanospheres of different diameters have been investigated using a vector network analyzer. The reflection loss of Fe3O4 nanospheres/paraffin wax composite can reach as high as -30.00 dB at 17.50 GHz and -37.95 dB at 7.67 GHz for Fe3O4 nanospheres with diameter of about 120 nm and 170 nm, respectively. The absorption bandwidth with reflection loss below -10 dB is up to 7.01 GHz when the Fe3O4 diameter is about 220 nm. In contrast, the bandwidth decreased to 4.28 GHz when the size shrank to 70 nm. Therefore, our method can be utilized to precisely control the size of Fe3O4 nanospheres in order to manipulate their electromagnetic wave absorption properties.

  7. Frequency Bandwidth Optimization of Left-Handed Metamaterial

    NASA Technical Reports Server (NTRS)

    Chevalier, Christine T.; Wilson, Jeffrey D.

    2004-01-01

    Recently, left-handed metamaterials (LHM s) have been demonstrated with an effective negative index of refraction and with antiparallel group and phase velocities for microwave radiation over a narrow frequency bandwidth. In order to take advantage of these characteristics for practical applications, it will be beneficial to develop LHM s with increased frequency bandwidth response and lower losses. In this paper a commercial three-dimensional electromagnetic simulation code is used to explore the effects of geometry parameter variations on the frequency bandwidth of a LHM at microwave frequencies. Utilizing an optimizing routine in the code, a geometry was generated with a bandwidth more than twice as large as the original geometry.

  8. PIC Simulation of Laser Plasma Interactions with Temporal Bandwidths

    NASA Astrophysics Data System (ADS)

    Tsung, Frank; Weaver, J.; Lehmberg, R.

    2015-11-01

    We are performing particle-in-cell simulations using the code OSIRIS to study the effects of laser plasma interactions in the presence of temperal bandwidths under conditions relevant to current and future shock ignition experiments on the NIKE laser. Our simulations show that, for sufficiently large bandwidth, the saturation level, and the distribution of hot electrons, can be effected by the addition of temporal bandwidths (which can be accomplished in experiments using smoothing techniques such as SSD or ISI). We will show that temporal bandwidth along play an important role in the control of LPI's in these lasers and discuss future directions. This work is conducted under the auspices of NRL.

  9. Bandwidth enhancement of a dual band planar monopole antenna using meandered microstrip feeding.

    PubMed

    Ahsan, M R; Islam, M T; Habib Ullah, M; Misran, N

    2014-01-01

    A meandered-microstrip fed circular shaped monopole antenna loaded with vertical slots on a high dielectric material substrate (ε r = 15) is proposed in this paper. The performance criteria of the proposed antenna have been experimentally verified by fabricating a printed prototype. The experimental results show that the proposed antenna has achieved wider bandwidth with satisfactory gain by introducing meandered-microstrip feeding in assistant of partial ground plane. It is observed that, the -10 dB impedance bandwidth of the proposed antenna at lower band is 44.4% (600 MHz-1 GHz) and at upper band is 28% (2.25 GHz-2.95 GHz). The measured maximum gains of -1.18 dBi and 4.87 dBi with maximum radiation efficiencies have been observed at lower band and upper band, respectively. The antenna configuration and parametric study have been carried out with the help of commercially available computer-aided EM simulator, and a good accordance is perceived in between the simulated and measured results. The analysis of performance criteria and almost consistent radiation pattern make the proposed antenna a suitable candidate for UHF RFID, WiMAX, and WLAN applications. PMID:24723832

  10. Bandwidth enhancement of a dual band planar monopole antenna using meandered microstrip feeding.

    PubMed

    Ahsan, M R; Islam, M T; Habib Ullah, M; Misran, N

    2014-01-01

    A meandered-microstrip fed circular shaped monopole antenna loaded with vertical slots on a high dielectric material substrate (ε r = 15) is proposed in this paper. The performance criteria of the proposed antenna have been experimentally verified by fabricating a printed prototype. The experimental results show that the proposed antenna has achieved wider bandwidth with satisfactory gain by introducing meandered-microstrip feeding in assistant of partial ground plane. It is observed that, the -10 dB impedance bandwidth of the proposed antenna at lower band is 44.4% (600 MHz-1 GHz) and at upper band is 28% (2.25 GHz-2.95 GHz). The measured maximum gains of -1.18 dBi and 4.87 dBi with maximum radiation efficiencies have been observed at lower band and upper band, respectively. The antenna configuration and parametric study have been carried out with the help of commercially available computer-aided EM simulator, and a good accordance is perceived in between the simulated and measured results. The analysis of performance criteria and almost consistent radiation pattern make the proposed antenna a suitable candidate for UHF RFID, WiMAX, and WLAN applications.

  11. Anti-hyperlipidemic effect of soybean extract fermented by Bacillus subtilis MORI in db/db mice

    PubMed Central

    Nam, YoonYi; Jung, Harry; Karuppasamy, Sankarapandian; Lee, Jae-Yeon; Kang, Kyung-Don; Hwang, Kyo-Yeol; Seong, Su-Il

    2012-01-01

    The purpose of this study was to investigate the anti-hyperlipidemic effect of soy bean extract solution fermented by Bacillus subtilis MORI (BTD-1E) in obese db/db mice. Eight-week-old male db/db mice were administered 33.3 mg/kg BTD-1E solution orally once a day for four weeks. The BTD-1E group showed significantly lower body weight compared with the db control group (P<0.05). The BTD-1E group showed significantly lower serum total cholesterol and LDL cholesterol levels compared with the db control group, respectively (P<0.05, P<0.01). The BTD-1E group showed significantly decreased liver weight relative to final body weight compared with the db control group (P<0.01). After four weeks of BTD-1E administration, lipid droplets in the liver were apparently decreased in the BTD-1E group compared to the db control group. In summary, our results suggest that BTD-1E has an anti-hyperlipidemic effect in the obese mouse model. PMID:22787486

  12. Development of high frequency and wide bandwidth Johnson noise thermometry

    SciTech Connect

    Crossno, Jesse; Liu, Xiaomeng; Kim, Philip; Ohki, Thomas A.; Fong, Kin Chung

    2015-01-12

    We develop a high frequency, wide bandwidth radiometer operating at room temperature, which augments the traditional technique of Johnson noise thermometry for nanoscale thermal transport studies. Employing low noise amplifiers and an analog multiplier operating at 2 GHz, auto- and cross-correlated Johnson noise measurements are performed in the temperature range of 3 to 300 K, achieving a sensitivity of 5.5 mK (110 ppm) in 1 s of integration time. This setup allows us to measure the thermal conductance of a boron nitride encapsulated monolayer graphene device over a wide temperature range. Our data show a high power law (T ∼ 4) deviation from the Wiedemann-Franz law above T ∼ 100 K.

  13. Efficient use of bandwidth for underwater acoustic communication.

    PubMed

    Song, H C; Hodgkiss, W S

    2013-08-01

    In a recent shallow water experiment, acoustic communication transmissions were carried out over the 10 to 32 kHz band in ~100 m deep water over a 3 km range. A natural question is how best to utilize that bandwidth. In one multiband approach discussed previously, the band was divided into four smaller subbands that were processed independently using time reversal decision-feedback equalizers (TR-DFEs). This letter presents a complementary wideband approach using data from the same experiment achieving a data rate of up to 60 kbits/s with 32 quadrature amplitude modulation. These results suggest that a wideband approach can be beneficial in terms of spectral efficiency with modest computational complexity using a TR-DFE.

  14. Bandwidth control in a hybrid fiber acousto-optic filter.

    PubMed

    Jung, Y; Lee, S B; Lee, Jhang W; Oh, K

    2005-01-01

    We report a bandwidth variation technique in an acousto-optic filter. Utilizing the adiabatic conversion in both optical and acoustic modes, we obtain a novel hybrid waveguide composed of serial concatenation of single-mode fiber (SMF) and two-mode hollow optical fiber (HOF). On the basis of dissimilarity in the phase-matching conditions and beat-length dispersion in SMF and HOF, the FWHM of the resonant bands is varied from 3.8 to 190 nm near the 1.5-microm region in a single device. Furthermore, we theoretically analyze the acousto-optic coupling among the guided modes in HOF, which shows good agreement with experimental observations. PMID:15648646

  15. 47 CFR 101.809 - Bandwidth and emission limitations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false Bandwidth and emission limitations. 101.809 Section 101.809 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.809 Bandwidth and...

  16. 47 CFR 101.809 - Bandwidth and emission limitations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false Bandwidth and emission limitations. 101.809 Section 101.809 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.809 Bandwidth and...

  17. 47 CFR 101.809 - Bandwidth and emission limitations.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bandwidth and emission limitations. 101.809 Section 101.809 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.809 Bandwidth and...

  18. 47 CFR 101.809 - Bandwidth and emission limitations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bandwidth and emission limitations. 101.809 Section 101.809 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.809 Bandwidth and...

  19. 47 CFR 101.809 - Bandwidth and emission limitations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false Bandwidth and emission limitations. 101.809 Section 101.809 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES Local Television Transmission Service § 101.809 Bandwidth and...

  20. Optimal Bandwidth Selection in Observed-Score Kernel Equating

    ERIC Educational Resources Information Center

    Häggström, Jenny; Wiberg, Marie

    2014-01-01

    The selection of bandwidth in kernel equating is important because it has a direct impact on the equated test scores. The aim of this article is to examine the use of double smoothing when selecting bandwidths in kernel equating and to compare double smoothing with the commonly used penalty method. This comparison was made using both an equivalent…

  1. 47 CFR 2.1049 - Measurements required: Occupied bandwidth.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... established at the frequency of maximum response of the audio modulating circuit. (2) Single sideband....1049 Section 2.1049 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY ALLOCATIONS... Certification § 2.1049 Measurements required: Occupied bandwidth. The occupied bandwidth, that is the...

  2. The effect of bandwidth on telerobot system performance

    NASA Technical Reports Server (NTRS)

    Uebel, Mark; Ali, Michael S.; Minis, Ioannis

    1991-01-01

    The purpose of the experiment was to determine the effect that various slave-joint bandwidths have on telerobot system performance. The telerobot system consisted of a slave arm controlled by a master. The slave incorporated an impedance loop to provide local compliance in addition to the compliance provided by the operator via force feedback. Three joint bandwidths, 0.5, 1.0, and 2.0 Hz, were used. The performance measures were the task completion time and the sums of the squared forces and moments exerted on the environment. The task consisted of peg-in-hole insertion and removal. The results of the experiment indicate a significant performance decrease at 0.5-Hz bandwidth relative to the 1- and 2-Hz bandwidths. There was no significant change in performance between the 1- and 2-Hz bandwidths.

  3. The effect of stimulus bandwidth on binaural loudness summation.

    PubMed

    Shao, Zhiyue; Mo, Fangshuo; Mao, Dongxing

    2015-09-01

    Binaural loudness summation is an important property of the human auditory system. This paper presents an experimental investigation of how binaural loudness summation varies with stimulus bandwidth. Loudness matches were obtained between dichotic stimuli, with interaural level differences (ILDs) of 2-12 dB, and diotic stimuli. The stimuli were noise bands with seven center frequencies and four bandwidths. Results showed that the loudness of dichotic stimuli increased nonlinearly with ILD, the increase being slightly less with broader bandwidths. There was a bandwidth-dependent difference between the listening tests results and the predictions of Moore and Glasberg's [(2007) J. Acoust. Soc. Am. 121, 1604-1612] loudness model. The size of the difference was, however, small. A characteristic function was derived describing how overall loudness depends on stimulus bandwidth and ILD. PMID:26428788

  4. Analysis of blocking rate and bandwidth usage of mobile IPTV services in wireless cellular networks.

    PubMed

    Li, Mingfu

    2014-01-01

    Mobile IPTV services over wireless cellular networks become more and more popular, owing to the significant growth in access bandwidth of wireless cellular networks such as 3G/4G and WiMAX. However, the spectrum resources of wireless cellular networks is rare. How to enhance the spectral efficiency of mobile networks becomes an important issue. Unicast, broadcast, and multicast are the most important transport schemes for offering mobile IPTV services over wireless cellular networks. Therefore, bandwidth usages and blocking rates of unicast, broadcast, and multicast IPTV services were analyzed and compared in this paper. Simulations were also conducted to validate the analytical results. Numerical results demonstrate that the presented analysis is correct, and multicast scheme achieves the best bandwidth usage and blocking rate performance, relative to the other two schemes. PMID:25379521

  5. Optimizing the bandwidth and noise performance of distributed multi-pump Raman amplifiers

    NASA Astrophysics Data System (ADS)

    Liu, Xueming; Li, Yanhe

    2004-02-01

    Based on hybrid genetic algorithm (HGA), the signal bandwidth of the distributed multi-pump Raman amplifiers is optimized, and the corresponding noise figure is obtained. The results show that: (1) the optimal signal bandwidth Δ λ decreases with the increase of the span length L, e.g., Δ λ is 79.6 nm for L=50 km and 41.5 nm for L=100 km under our simulated conditions; (2) the relationship between Δ λ and L is approximately linear; (3) the equivalent noise figure can be negative and increases with the extension of L; (4) there are one or several global maximum signal bandwidth on the determinate conditions; (5) to realize the fixed Δ λ, several candidates can be obtained by means of HGA, as has important applications on the design of distributed multi-pump Raman amplifiers in practice.

  6. Analysis of Blocking Rate and Bandwidth Usage of Mobile IPTV Services in Wireless Cellular Networks

    PubMed Central

    Li, Mingfu

    2014-01-01

    Mobile IPTV services over wireless cellular networks become more and more popular, owing to the significant growth in access bandwidth of wireless cellular networks such as 3G/4G and WiMAX. However, the spectrum resources of wireless cellular networks is rare. How to enhance the spectral efficiency of mobile networks becomes an important issue. Unicast, broadcast, and multicast are the most important transport schemes for offering mobile IPTV services over wireless cellular networks. Therefore, bandwidth usages and blocking rates of unicast, broadcast, and multicast IPTV services were analyzed and compared in this paper. Simulations were also conducted to validate the analytical results. Numerical results demonstrate that the presented analysis is correct, and multicast scheme achieves the best bandwidth usage and blocking rate performance, relative to the other two schemes. PMID:25379521

  7. Analysis of blocking rate and bandwidth usage of mobile IPTV services in wireless cellular networks.

    PubMed

    Li, Mingfu

    2014-01-01

    Mobile IPTV services over wireless cellular networks become more and more popular, owing to the significant growth in access bandwidth of wireless cellular networks such as 3G/4G and WiMAX. However, the spectrum resources of wireless cellular networks is rare. How to enhance the spectral efficiency of mobile networks becomes an important issue. Unicast, broadcast, and multicast are the most important transport schemes for offering mobile IPTV services over wireless cellular networks. Therefore, bandwidth usages and blocking rates of unicast, broadcast, and multicast IPTV services were analyzed and compared in this paper. Simulations were also conducted to validate the analytical results. Numerical results demonstrate that the presented analysis is correct, and multicast scheme achieves the best bandwidth usage and blocking rate performance, relative to the other two schemes.

  8. Optical Sideband Generation: a Longitudinal Electron Beam Diagnostic Beyond the Laser Bandwidth Resolution Limit

    SciTech Connect

    Lawrence Berkeley National Laboratory; Tilborg, J. van; Matlis, N. H.; Plateau, G. R.; Leemans, W. P.

    2010-06-01

    Electro-optic sampling (EOS) is widely used as a technique to measure THz-domain electric field pulses such asthe self-fields of femtosecond electron beams. We present an EOS-based approach for single-shot spectral measurement that excels in simplicity (compatible with fiber integration) and bandwidth coverage (overcomes the laser bandwidth limitation), allowing few-fs electron beams or single-cycle THz pulses to be characterized with conventional picosecond probes. It is shown that the EOS-induced optical sidebands on the narrow-bandwidth optical probe are spectrally-shifted replicas of the THz pulse. An experimental demonstration on a 0-3 THz source is presented.

  9. First real-time experimental demonstrations of 11.25Gb/s optical OFDMA PONs with adaptive dynamic bandwidth allocation.

    PubMed

    Jin, X Q; Hugues-Salas, E; Giddings, R P; Wei, J L; Groenewald, J; Tang, J M

    2011-10-10

    End-to-end real-time experimental demonstrations are reported, for the first time, of aggregated 11.25Gb/s over 26.4km standard SMF, optical orthogonal frequency division multiple access (OOFDMA) PONs with adaptive dynamic bandwidth allocation (DBA). The demonstrated intensity-modulation and direct-detection (IMDD) OOFDMA PON system consists of two optical network units (ONUs), each of which employs a DFB-based directly modulated laser (DML) or a VCSEL-based DML for modulating upstream signals. Extensive experimental explorations of dynamic OOFDMA PON system properties are undertaken utilizing identified optimum DML operating conditions. It is shown that, for simultaneously achieving acceptable BERs for all upstream signals, the OOFDMA PON system has a >3dB dynamic ONU launch power variation range, and the BER performance of the system is insusceptible to any upstream symbol offsets slightly smaller than the adopted cyclic prefix. In addition, experimental results also indicate that, in addition to maximizing the aggregated system transmission capacity, adaptive DBA can also effectively reduce imperfections in transmission channel properties without affecting signal bit rates offered to individual ONUs. PMID:21997063

  10. High Current Responsivity and Wide Modulation Bandwidth Terahertz Detector Using High-Electron-Mobility Transistor for Wireless Communication

    NASA Astrophysics Data System (ADS)

    Suzuki, S.; Nukariya, T.; Ueda, Y.; Otsuka, T.; Asada, M.

    2016-07-01

    A high-current-responsivity terahertz (THz) detector was fabricated using a broadband bow-tie antenna and an InAlAs/InGaAs high-electron-mobility transistor (HEMT) with a short gate length. High-current responsivity can be achieved by using a short gate length; the resulting high transconductance exhibited ballistic transport in the channel. We fabricated the HEMT detector with a 50-nm-long channel; the transconductance was 1.2 S/mm and the subthreshold slope was 120 mV/dec, yielding a high-current responsivity (˜5 A/W) and a cutoff frequency of 460 GHz. We also measured the modulation bandwidth of the THz detector using a heterodyne mixing technique with a uni-traveling carrier photodiode (UTC-PD) for providing the radio frequency (RF) and a frequency multiplier as a local oscillator. The intensity of the intermediate signal (IF) was measured by changing the frequency of the UTC-PD; very high bandwidths of up to 26 GHz were obtained. The experimental results agree well with electromagnetic simulations, which indicate that the bandwidth is determined by the external circuit. The conversion gain from RF to IF was -2 dB in the heterodyne mixing by using the HEMT detector.

  11. Power and Efficiency Optimized in Traveling-Wave Tubes Over a Broad Frequency Bandwidth

    NASA Technical Reports Server (NTRS)

    Wilson, Jeffrey D.

    2001-01-01

    A traveling-wave tube (TWT) is an electron beam device that is used to amplify electromagnetic communication waves at radio and microwave frequencies. TWT's are critical components in deep space probes, communication satellites, and high-power radar systems. Power conversion efficiency is of paramount importance for TWT's employed in deep space probes and communication satellites. A previous effort was very successful in increasing efficiency and power at a single frequency (ref. 1). Such an algorithm is sufficient for narrow bandwidth designs, but for optimal designs in applications that require high radiofrequency power over a wide bandwidth, such as high-density communications or high-resolution radar, the variation of the circuit response with respect to frequency must be considered. This work at the NASA Glenn Research Center is the first to develop techniques for optimizing TWT efficiency and output power over a broad frequency bandwidth (ref. 2). The techniques are based on simulated annealing, which has the advantage over conventional optimization techniques in that it enables the best possible solution to be obtained (ref. 3). Two new broadband simulated annealing algorithms were developed that optimize (1) minimum saturated power efficiency over a frequency bandwidth and (2) simultaneous bandwidth and minimum power efficiency over the frequency band with constant input power. The algorithms were incorporated into the NASA coupled-cavity TWT computer model (ref. 4) and used to design optimal phase velocity tapers using the 59- to 64-GHz Hughes 961HA coupled-cavity TWT as a baseline model. In comparison to the baseline design, the computational results of the first broad-band design algorithm show an improvement of 73.9 percent in minimum saturated efficiency (see the top graph). The second broadband design algorithm (see the bottom graph) improves minimum radiofrequency efficiency with constant input power drive by a factor of 2.7 at the high band edge (64

  12. Microstrip resonators and filters using high-T sub c superconducting thin films on LaAlO sub 3

    SciTech Connect

    Takemoto, J.I.; Jackson, C.M.; Hu, R.; Burch, J.F.; Daly, K.P.; Simon, R.W. )

    1991-03-01

    This paper reports on very low microwave losses in YBa {sub 2}Cu{sub 3}O{sub 7} linear resonators, ring resonators, and bandpass filters. We deposited the 1-2-3 on LaAlO{sub 3} substrates, patterned microwave circuits, and overcoated with a passivating LaAlO{sub 3} layer. HTS linear microstrip resonators demonstrated Q's greater than 1200 at 10 GHz, corresponding to surface resistances less than 300 {mu}{omega}. Identical silver resonators showed Q's of 60 and surface resistance of 15 m{omega}. The high frequency transition temperature for these HTS films was greater than 83 K. The authors measured Q's of 240 in ring resonators at 15 GHz. Finally, the authors designed, fabricated, and tested a 2-pole, Chebyshev narrow-bandwidth bandpass filter. The HTS filter was designed to be a 1 percent bandwidth with 0.1 dB ripple. Insertion loss was 2 dB at 4 K, rising to 3 dB at 77 K. The authors observed temperature dependence in the filter center frequency, which we attribute to kinetic inductance effects. The authors' HTS filters outperform similar cryogenic silver filters, indicating that practical levels of HTS performance have been achieved.

  13. Ultra-broad bandwidth parametric amplification at degeneracy.

    PubMed

    Limpert, J; Aguergaray, C; Montant, S; Manek-Hönninger, I; Petit, S; Descamps, D; Cormier, E; Salin, F

    2005-09-19

    We report on a novel approach of ultra-broad bandwidth parametric amplification around degeneracy. A bandwidth of up to 400 nm centered around 800 nm is amplified in a BBO crystal by using chirped pump pulses with a bandwitdth as broad as 10 nm. A supercontinuum signal is generated in a microstructured fiber, having to first order a quadratic chirp, which is necessary to ensure temporal overlap of the interacting waves over this broad bandwidth. Furthermore, we discuss the potential of this approach for an octave-spanning parametric amplification.

  14. Anti-diabetic effect of amorphastilbol through PPARα/γ dual activation in db/db mice.

    PubMed

    Lee, Woojung; Ham, Jungyeob; Kwon, Hak Cheol; Kim, Yong Kee; Kim, Su-Nam

    2013-03-01

    Peroxisome proliferator-activated receptors (PPARs) have been considered as desirable targets for metabolic syndrome treatments, even though their specific agonists have several side effects, including body weight gain, edema, and tissue failure. The effects of amorphastilbol (APH) on glucose- and lipid metabolism were investigated with in vitro 3T3-L1 adipocyte systems and in vivo db/db mice model. APH selectively stimulates the transcriptional activities of both PPARα and PPARγ, which are able to enhance fatty acid oxidation and glucose utilization. Furthermore, APH improves glucose and lipid impairment in db/db mice. More importantly, there are no significant side effects, such as weight gain or hepatomegaly, in APH-treated animals, implying that APH do not adversely affect liver or lipid metabolism. All our data suggest that APH can be used as potential therapeutic agents against type 2 diabetes and related metabolic disorders, including obesity, by enhancing glucose and lipid metabolism. PMID:23376064

  15. Note: Expanding the bandwidth of the ultra-low current amplifier using an artificial negative capacitor

    NASA Astrophysics Data System (ADS)

    Xie, Kai; Liu, Yan; Li, XiaoPing; Guo, Lixin; Zhang, Hanlu

    2016-04-01

    The bandwidth and low noise characteristics are often contradictory in ultra-low current amplifier, because an inevitable parasitic capacitance is paralleled with the high value feedback resistor. In order to expand the amplifier's bandwidth, a novel approach was proposed by introducing an artificial negative capacitor to cancel the parasitic capacitance. The theory of the negative capacitance and the performance of the improved amplifier circuit with the negative capacitor are presented in this manuscript. The test was conducted by modifying an ultra-low current amplifier with a trans-impedance gain of 50 GΩ. The results show that the maximum bandwidth was expanded from 18.7 Hz to 3.3 kHz with more than 150 times of increase when the parasitic capacitance (˜0.17 pF) was cancelled. Meanwhile, the rise time decreased from 18.7 ms to 0.26 ms with no overshot. Any desired bandwidth or rise time within these ranges can be obtained by adjusting the ratio of cancellation of the parasitic and negative capacitance. This approach is especially suitable for the demand of rapid response to weak current, such as transient ion-beam detector, mass spectrometry analysis, and fast scanning microscope.

  16. Note: Expanding the bandwidth of the ultra-low current amplifier using an artificial negative capacitor.

    PubMed

    Xie, Kai; Liu, Yan; Li, XiaoPing; Guo, Lixin; Zhang, Hanlu

    2016-04-01

    The bandwidth and low noise characteristics are often contradictory in ultra-low current amplifier, because an inevitable parasitic capacitance is paralleled with the high value feedback resistor. In order to expand the amplifier's bandwidth, a novel approach was proposed by introducing an artificial negative capacitor to cancel the parasitic capacitance. The theory of the negative capacitance and the performance of the improved amplifier circuit with the negative capacitor are presented in this manuscript. The test was conducted by modifying an ultra-low current amplifier with a trans-impedance gain of 50 GΩ. The results show that the maximum bandwidth was expanded from 18.7 Hz to 3.3 kHz with more than 150 times of increase when the parasitic capacitance (∼0.17 pF) was cancelled. Meanwhile, the rise time decreased from 18.7 ms to 0.26 ms with no overshot. Any desired bandwidth or rise time within these ranges can be obtained by adjusting the ratio of cancellation of the parasitic and negative capacitance. This approach is especially suitable for the demand of rapid response to weak current, such as transient ion-beam detector, mass spectrometry analysis, and fast scanning microscope. PMID:27131718

  17. 47 CFR 74.736 - Emissions and bandwidth.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ..., AUXILIARY, SPECIAL BROADCAST AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.736 Emissions and bandwidth. (a) The license of a low power TV, TV translator, or...

  18. Effect of bandwidth and numerical aperture in optical scatterometry

    NASA Astrophysics Data System (ADS)

    Germer, Thomas A.; Patrick, Heather J.

    2010-03-01

    We consider the effects of finite spectral bandwidth and numerical aperture in scatterometry measurements and discuss efficient integration methods based upon Gaussian quadrature in one dimension (for spectral bandwidth averaging) and two dimensions inside a circle (for numerical aperture averaging). Provided the wavelength is not near a Wood's anomaly for the grating, we find that the resulting methods converge very quickly to a level suitable for most measurement applications. In the vicinity of a Wood's anomaly, however, the methods provide rather poor behavior. We also describe a method that can be used to extract the effective spectral bandwidth and numerical aperture for a scatterometry tool. We find that accounting for spectral bandwidth and numerical aperture is necessary to obtain satisfactory results in scatterometry.

  19. Eye-Movement Tracker Would Reduce Video Bandwidth

    NASA Technical Reports Server (NTRS)

    Ruoff, C. F.

    1985-01-01

    Bandwidth required to transmit closed circuit television image reduced by transmitting small portion at high resolution and remainder at low resolution. High-resolution portion centered in viewer's gaze so entire image seems to be of high resolution.

  20. 47 CFR 74.736 - Emissions and bandwidth.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ..., AUXILIARY, SPECIAL BROADCAST AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.736 Emissions and bandwidth. (a) The license of a low power TV, TV translator, or...

  1. 47 CFR 74.736 - Emissions and bandwidth.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ..., AUXILIARY, SPECIAL BROADCAST AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.736 Emissions and bandwidth. (a) The license of a low power TV, TV translator, or...

  2. 47 CFR 74.736 - Emissions and bandwidth.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ..., AUXILIARY, SPECIAL BROADCAST AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.736 Emissions and bandwidth. (a) The license of a low power TV, TV translator, or...

  3. 47 CFR 74.736 - Emissions and bandwidth.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ..., AUXILIARY, SPECIAL BROADCAST AND OTHER PROGRAM DISTRIBUTIONAL SERVICES Low Power TV, TV Translator, and TV Booster Stations § 74.736 Emissions and bandwidth. (a) The license of a low power TV, TV translator, or...

  4. Napter Was Just the Start of the Bandwidth Invasion.

    ERIC Educational Resources Information Center

    Carlson, Scott

    2001-01-01

    Colleges are finding that, regardless of the court rulings against Napster, file-sharing services remain popular with students and problematic to campus networks because of the demand placed on bandwidth by music and video files. (EV)

  5. Equivalent statistical bandwidths of conventional low-pass filters

    NASA Technical Reports Server (NTRS)

    Stanley, W. D.; Peterson, S. J.

    1979-01-01

    Values of the equivalent statistical bandwidths of Butterworth up to ten poles and Chebyshev up to eight poles low-pass filters for six different passband ripple levels have been computed and tabulated along with the corresponding noise bandwidths. The results obtained can be used for estimating the mean-square error resulting from power spectrum measurements employed in the sensitivity analysis of microwave radiometer systems.

  6. Laser frequency bandwidth narrowing by photorefractive two-beam coupling.

    PubMed

    Chomsky, D; Sternklar, S; Zigler, A; Jackel, S

    1992-04-01

    We present a theoretical analysis and experimental demonstration of a new method for spectral narrowing of laser radiation. The bandwidth narrowing is experienced by a laser beam subjected to a photorefractive two-beam coupling process. Contrary to the conventional method of frequency filtering by a Fabry-Perot étalon, this technique has no intrinsic finesse limitation on its resolution. A factor of 2 in frequency bandwidth narrowing is achieved with an argon-ion laser.

  7. Bandwidth extension for IR detectors through spatial-frequency shifting.

    PubMed

    Lettington, A H; Hong, Q H; Tzimopoulou, S

    1996-09-10

    We describe a new scheme for extending the bandwidth of IR detectors by the employment of a reticle that shifts the higher spatial-frequency content of the scene onto the lower-frequency region. Then all the spatial-frequency information can pass through the bandwidth of the detector system, so that a high-resolution image may be reconstructed from a series of pictures obtained with the reticle in a number of predetermined positions. PMID:21127517

  8. Fuzzy-based adaptive bandwidth control for loss guarantees.

    PubMed

    Siripongwutikorn, Peerapon; Banerjee, Sujata; Tipper, David

    2005-09-01

    This paper presents the use of adaptive bandwidth control (ABC) for a quantitative packet loss rate guarantee to aggregate traffic in packet switched networks. ABC starts with some initial amount of bandwidth allocated to a queue and adjusts it over time based on online measurements of system states to ensure that the allocated bandwidth is just enough to attain the specified loss requirement. Consequently, no a priori detailed traffic information is required, making ABC more suitable for efficient aggregate quality of service (QoS) provisioning. We propose an ABC algorithm called augmented Fuzzy (A-Fuzzy) control, whereby fuzzy logic control is used to keep an average queue length at an appropriate target value, and the measured packet loss rate is used to augment the standard control to achieve better performance. An extensive simulation study based on both theoretical traffic models and real traffic traces under a wide range of system configurations demonstrates that the A-Fuzzy control itself is highly robust, yields high bandwidth utilization, and is indeed a viable alternative and improvement to static bandwidth allocation (SBA) and existing adaptive bandwidth allocation schemes. Additionally, we develop a simple and efficient measurement-based admission control procedure which limits the amount of input traffic in order to maintain the performance of the A-Fuzzy control at an acceptable level.

  9. An Ultra-Low Bandwidth Video Transmission System

    NASA Astrophysics Data System (ADS)

    Percival, J. W.; White, R. L.

    We have developed a Progressive Video Transmission system that is suitable for use over ultra-low bandwidth connections, which we define as phone-grade connections of 28,800 bits per second (bps) or less. Our system is not designed for person-to-person videoconferencing. Rather, it is designed as a video frame browser for observatory video systems whose signals typically represent guide cameras, wavefront sensors, slit-viewing cameras, and so on. We have found that videoconferencing products are not suitable for ultra-low bandwidth connections or for video frames containing possibly significant scientific content because they often sacrifice image quality to maintain frame rate, require bandwidths of 100 kbps or more, and consume all available bandwidth between the client and server. Our system allows the user to control image quality, resolution and bandwidth on the fly, and uses a variety of compression techniques to achieve compression factors of about 5 with little apparent degradation of the images. The transmission is progressive, with the quality of each frame improving during its transmission. It supports multiple remote users, allowing each to work at their own baud and frame rates. A Tk-based GUI allows the user to control image quality and frame rate, select image size, set maximum bandwidth, save frames to disk, and change channels remotely. This system is in use at the WIYN Observatory.

  10. Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice

    PubMed Central

    2013-01-01

    Background The anti-diabetic drug metformin has been demonstrated to exert a protective effect against vascular complications in diabetes independent of its glucose lowering action. Since the endothelial glycocalyx has been indicated to have important vasculoprotective properties and to be vulnerable to degradation by hyperglycemic conditions, we evaluated in the current study the effect of short-term metformin treatment on whole-body glycocalyx barrier properties in a mouse model of non-insulin dependent diabetes mellitus (db/db mouse). Methods Glycocalyx barrier properties were measured in an acute experiment in three groups of mice: 1) db/db mice without treatment serving as controls, 2) db/db mice which received metformin for two weeks in the drinking water serving as experimental group, and 3) C57Bl/6 mice serving as reference group. Animals were put under anesthesia (ketamine, medetomidine, and atropine) and carotid artery blood pressure was continuously monitored. To probe the glycocalyx a mixture of the tracers FITC-labeled 70 kDa dextrans (Dex70) or fluorescein-labeled red blood cells (RBCs) versus Texas Red-labeled 40 kDa dextrans (Dex40) was infused and blood samples subsequently collected for 30 min to determine the initial vascular distribution volume and clearance of these tracers. Urine was collected and dry-to-wet weight of heart and kidney were determined after the experiment. Group differences were tested using unpaired t-tests. Results Metformin treatment did not affect body weight, fasting blood glucose and arterial blood pressure. Compared to C57Bl/6 mice, db/db mice showed a diminished initial exclusion and increased vascular clearance of Dex70 versus Dex40 (P < 0.05), and both were improved by the metformin treatment (P < 0.05). While urine production was higher in the db/db mice compared to C57Bl/6 (P < 0.05), heart and kidney of the metformin treated animals showed comparable dry-to-wet weights compared to the C57Bl/6 mice

  11. Scaling Mesa Indium Phosphide DHBTs to Record Bandwidths

    NASA Astrophysics Data System (ADS)

    Lobisser, Evan

    Indium phosphide heterojunction bipolar transistors are able to achieve higher bandwidths at a given feature size than transistors in the Silicon material system for a given feature size. Indium phosphide bipolar transistors demonstrate higher breakdown voltages at a given bandwidth than both Si bipolars and field effect transistors in the InP material system. The high bandwidth of InP HBTs results from both intrinsic material parameters and bandgap engineering through epitaxial growth. The electron mobility in the InGaAs base and saturation velocity in the InP collector are both approximately three times higher than their counterparts in the SiGe material system. Resistance of the base can be made very low due to the large offset in the valence band between the InP emitter and the InGaAs base, which allows the base to be doped on the order of 1020 cm-3 with negligible reduction in emitter injection efficiency. This thesis deals with type-I, NPN dual-heterojunction bipolar transistors. The emitters are InP, and the base is InGaAs. There is a thin (˜ 10 nm) n-type InGaAs "setback" region, followed by a chirped superlattice InGaAs/InAlAs grade to the InP collector. The setback, grade, and collector are all lightly doped n-type. The emitter and collector are contacted through thin (˜ 5 nm) heavily doped n-type InGaAs layers to reduce contact resistivity. The primary focus of this work is increasing the bandwidth of InP HBTs through the proportional scaling of the device dimensions, both layer thicknesses and junction areas, as well as the reduction of the contact resistivities associated with the transistor. Essentially, all RC time constants and transit times must be reduced by a factor of two to double a transistor's bandwidth. Chapter 2 describes in detail the scaling laws and design principles for high frequency bipolar transistor design. A low-stress, blanket sputter deposited composite emitter metal process was developed. Refractory metal base contacts were

  12. Manipulating the ferromagnetism in narrow-bandwidth Pr{sub 1-x}Ca{sub x}MnO{sub 3} (0 ≤ x ≤ 0.6) by means of the Mn-Ru t{sub 2g} ferromagnetic super-exchanges

    SciTech Connect

    Wang, Y. L.; Liu, M. F.; Xie, Y. L.; Yan, Z. B.; Dong, S.; Liu, J.-M.

    2015-09-28

    The concurrent ferromagnetic and metal-insulator transitions via the double-exchange route and electronic phase separation scenario represent the core ingredients of the physics of manganites. In this work, a Ca{sup 2+} and Ru{sup 4+} co-substitution of Pr{sup 3+} and Mn{sup 3+} in narrow-bandwidth and insulating PrMnO{sub 3}, namely, Pr{sub 1-x}Ca{sub x}Mn{sub 1-x}Ru{sub x}O{sub 3} (PCMRO, x ≤ 0.6), is carried out in order to investigate an alternative approach to effectively manipulate the ferromagnetism of PrMnO{sub 3}-based manganites. It is revealed that PCMRO over the whole substitution range is homogeneous solid solution with increased lattice distortion. The preference of Ru{sup 4+} valence state and the absence of Mn{sup 4+} valence state disable the Mn{sup 3+}-Mn{sup 4+} e{sub g}-orbital double-exchange, and the random occupation of Ru{sup 4+} in the lattice excludes the charge ordering and electronic phase separation. While all these consequences should favor antiferromagnetic insulating states, nevertheless, a high-temperature ferromagnetic transition is triggered by the co-substitution and the magnetization can reach up to ∼1.0 μ{sub B}/f.u. at x ∼ 0.2–0.3, much bigger than the moment (<0.1 μ{sub B}/f.u.) of Pr{sub 1−x}Ca{sub x}MnO{sub 3} in the weak ferromagnetic insulator state. It is suggested that this strong ferromagnetism is substantially ascribed to the Mn{sup 3+}-Ru{sup 4+} t{sub 2g}-orbital ferromagnetic super-exchange, and a simple geometric network illustration of the magnetism and electrical transport is presented.

  13. Effects of bandwidth, compression speed, and gain at high frequencies on preferences for amplified music.

    PubMed

    Moore, Brian C J

    2012-09-01

    This article reviews a series of studies on the factors influencing sound quality preferences, mostly for jazz and classical music stimuli. The data were obtained using ratings of individual stimuli or using the method of paired comparisons. For normal-hearing participants, the highest ratings of sound quality were obtained when the reproduction bandwidth was wide (55 to 16000 Hz) and ripples in the frequency response were small (less than ± 5 dB). For hearing-impaired participants listening via a simulated five-channel compression hearing aid with gains set using the CAM2 fitting method, preferences for upper cutoff frequency varied across participants: Some preferred a 7.5- or 10-kHz upper cutoff frequency over a 5-kHz cutoff frequency, and some showed the opposite preference. Preferences for a higher upper cutoff frequency were associated with a shallow high-frequency slope of the audiogram. A subsequent study comparing the CAM2 and NAL-NL2 fitting methods, with gains slightly reduced for participants who were not experienced hearing aid users, showed a consistent preference for CAM2. Since the two methods differ mainly in the gain applied for frequencies above 4 kHz (CAM2 recommending higher gain than NAL-NL2), these results suggest that extending the upper cutoff frequency is beneficial. A system for reducing "overshoot" effects produced by compression gave small but significant benefits for sound quality of a percussion instrument (xylophone). For a high-input level (80 dB SPL), slow compression was preferred over fast compression. PMID:23172008

  14. Effects of Bandwidth, Compression Speed, and Gain at High Frequencies on Preferences for Amplified Music

    PubMed Central

    2012-01-01

    This article reviews a series of studies on the factors influencing sound quality preferences, mostly for jazz and classical music stimuli. The data were obtained using ratings of individual stimuli or using the method of paired comparisons. For normal-hearing participants, the highest ratings of sound quality were obtained when the reproduction bandwidth was wide (55 to 16000 Hz) and ripples in the frequency response were small (less than ± 5 dB). For hearing-impaired participants listening via a simulated five-channel compression hearing aid with gains set using the CAM2 fitting method, preferences for upper cutoff frequency varied across participants: Some preferred a 7.5- or 10-kHz upper cutoff frequency over a 5-kHz cutoff frequency, and some showed the opposite preference. Preferences for a higher upper cutoff frequency were associated with a shallow high-frequency slope of the audiogram. A subsequent study comparing the CAM2 and NAL-NL2 fitting methods, with gains slightly reduced for participants who were not experienced hearing aid users, showed a consistent preference for CAM2. Since the two methods differ mainly in the gain applied for frequencies above 4 kHz (CAM2 recommending higher gain than NAL-NL2), these results suggest that extending the upper cutoff frequency is beneficial. A system for reducing “overshoot” effects produced by compression gave small but significant benefits for sound quality of a percussion instrument (xylophone). For a high-input level (80 dB SPL), slow compression was preferred over fast compression. PMID:23172008

  15. γ-Fe2O3-MWNT/poly(p-phenylenebenzobisoxazole) composites with excellent microwave absorption performance and thermal stability.

    PubMed

    Chen, Yi; Liu, Xiaoyun; Mao, Xiaoyang; Zhuang, Qixin; Xie, Zhong; Han, Zhewen

    2014-06-21

    Ferromagnetic γ-Fe2O3 nanoparticles were successfully loaded into multi-walled carbon nanotubes (MWNTs) as probed by transmission electron microscopy. Upon incorporation of the γ-Fe2O3-MWNTs into poly(p-phenylenebenzobisoxazole) (PBO), a conjugated polymer with high mechanical strength and outstanding thermal and oxidative stability, microwave absorbing materials were obtained. Attributed to the special structure of the γ-Fe2O3-MWNTs, synergistic effects on dielectric loss and magnetic loss, and a better matched characteristic impedance of the composites were achieved. The optimal minimum reflection loss reached -32.7 dB at 12.09 GHz on a composite containing 12 wt% γ-Fe2O3-MWNTs with a thickness of 2.7 mm, and the corresponding bandwidth below -5 dB was 6.2 GHz. This demonstrated its potential applications as a low-density microwave absorbing material operating under extreme environments. PMID:24806979

  16. Mycophenolate Mofetil Ameliorates Diabetic Nephropathy in db/db Mice

    PubMed Central

    Seo, Jung-Woo; Kim, Yang Gyun; Lee, Sang Ho; Lee, Arah; Kim, Dong-Jin; Jeong, Kyung-Hwan; Lee, Kyung Hye; Hwang, Seung Joon; Woo, Jong Shin; Lim, Sung Jig; Kim, Weon; Moon, Ju-Young

    2015-01-01

    Chronic low-grade inflammation is an important factor in the pathogenesis of diabetic complication. Mycophenolate mofetil (MMF) has an anti-inflammatory effect, inhibiting lymphocyte proliferation. Previous studies showed attenuation of diabetic nephropathy with MMF, but the underlying mechanisms were unclear. This study aimed to identify the effect of MMF on diabetic nephropathy and investigate its action mechanisms in type 2 diabetic mice model. Eight-week-old db/db and control mice (db/m mice) received vehicle or MMF at a dose of 30 mg/kg/day for 12 weeks. MMF-treated diabetic mice showed decreased albuminuria, attenuated mesangial expansion, and profibrotic mRNA expressions despite the high glucose level. The number of infiltrated CD4+ and CD8+ T cells in the kidney was significantly decreased in MMF-treated db/db mice and it resulted in attenuating elevated intrarenal TNF-α and IL-17. The renal chemokines expression and macrophages infiltration were also attenuated by MMF treatment. The decreased expression of glomerular nephrin and WT1 was recovered with MMF treatment. MMF prevented the progression of diabetic nephropathy in db/db mice independent of glycemic control. These results suggest that the effects of MMF in diabetic nephropathy are mediated by CD4+ T cell regulation and related cytokines. PMID:26345532

  17. Electro-optic bandwidth manipulation of quantum light (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Karpinski, Michal; Jachura, Michal; Wright, Laura J.; Smith, Brian J.

    2016-04-01

    means of a highly dispersive chirped fiber Bragg grating. We verify the non-classicality of spectrally shifted single photons by measuring high-visibility Hong-Ou-Mandel interference using a reference single photon pulse. Spectral compression is based on the time lens principle, which requires locking optical pulses to approximately quadratic region of sinusoidal phase modulation. We utilize both 10 GHz and 40 GHz RF driving frequencies. Bandwidth compression is achieved by chirping the single photon pulse using an appropriate length of single-mode fibre and subsequently subjecting it to the action of the time lens. We verify spectral compression directly using the aforementioned spectrally-resolved heralded single photon counting method. We achieve 3-fold spectral compression of 2 nm bandwidth single photon pulses using 40 GHZ modulation frequency, and 6-fold spectral compression of 0.9 nm bandwidth single photon pulses using 10 GHz modulation frequency. Overall transmission of our set-up exceeding 30% enables practical usability of our spectral compression method which we demonstrate experimentally by showing an increased photon flux through a narrowband filter. Our results present an important contribution towards implementing quantum information processing in the spectral-temporal degree of freedom of a photon. In the context of quantum networks they present an enabling tool towards efficient photonic interfacing of different quantum information processing platforms.

  18. Anti-diabetic effect of amorphastilbol through PPARα/γ dual activation in db/db mice

    SciTech Connect

    Lee, Woojung; Ham, Jungyeob; Kwon, Hak Cheol; Kim, Yong Kee; Kim, Su-Nam

    2013-03-01

    Highlights: ► Amorphastilbol stimulates the transcriptional activities of both PPARα and PPARγ. ► Amorphastilbol improves glucose and lipid impairment in db/db mice. ► There are no side effects, such as hepatomegaly, in amorphastilbol-treated mice. ► Amorphastilbol can be used as a potential therapeutic agent against T2DM. - Abstract: Peroxisome proliferator-activated receptors (PPARs) have been considered as desirable targets for metabolic syndrome treatments, even though their specific agonists have several side effects, including body weight gain, edema, and tissue failure. The effects of amorphastilbol (APH) on glucose- and lipid metabolism were investigated with in vitro 3T3-L1 adipocyte systems and in vivo db/db mice model. APH selectively stimulates the transcriptional activities of both PPARα and PPARγ, which are able to enhance fatty acid oxidation and glucose utilization. Furthermore, APH improves glucose and lipid impairment in db/db mice. More importantly, there are no significant side effects, such as weight gain or hepatomegaly, in APH-treated animals, implying that APH do not adversely affect liver or lipid metabolism. All our data suggest that APH can be used as potential therapeutic agents against type 2 diabetes and related metabolic disorders, including obesity, by enhancing glucose and lipid metabolism.

  19. MicroRNA-29b Inhibits Diabetic Nephropathy in db/db Mice

    PubMed Central

    Chen, Hai-Yong; Zhong, Xiang; Huang, Xiao R; Meng, Xiao-Ming; You, Yongke; Chung, Arthur CK; Lan, Hui Y

    2014-01-01

    Inflammation and its consequent fibrosis are two main features of diabetic nephropathy (DN), but target therapy on these processes for DN remains yet ineffective. We report here that miR-29b is a novel therapeutic agent capable of inhibiting progressive renal inflammation and fibrosis in type 2 diabetes in db/db mice. Under diabetic conditions, miR-29b was largely downregulated in response to advanced glycation end (AGE) product, which was associated with upregulation of collagen matrix in mesangial cells via the transforming growth factor-β (TGF-β)/Smad3-dependent mechanism. These pathological changes were reversed by overexpressing miR-29b, but enhanced by knocking-down miR-29b. Similarly, loss of renal miR-29b was associated with progressive diabetic kidney injury, including microalbuminuria, renal fibrosis, and inflammation. Restored renal miR-29b by the ultrasound-based gene therapy was capable of attenuating diabetic kidney disease. Further studies revealed that inhibition of Sp1 expression, TGF-β/Smad3-dependent renal fibrosis, NF-κB–driven renal inflammation, and T-bet/Th1-mediated immune response may be mechanisms associated with miR-29b treatment in db/db mice. In conclusion, miR-29b may play a protective role in diabetic kidney disease and may have therapeutic potential for diabetic kidney complication. PMID:24445937

  20. High bandwidth piezoresistive force probes with integrated thermal actuation

    PubMed Central

    Doll, Joseph C.; Pruitt, Beth L.

    2012-01-01

    We present high-speed force probes with on-chip actuation and sensing for the measurement of pN-scale forces at the microsecond time scale. We achieve a high resonant frequency in water (1–100 kHz) with requisite low spring constants (0.3–40 pN/nm) and low integrated force noise (1–100 pN) by targeting probe dimensions on the order of 300 nm thick, 1–2 μm wide and 30–200 μm long. Forces are measured using silicon piezoresistors while the probes are actuated thermally with an aluminum unimorph and silicon heater. The piezoresistive sensors are designed using open source numerical optimization code that incorporates constraints on operating temperature. Parylene passivation enables operation in ionic media and we demonstrate simultaneous actuation and sensing. The improved design and fabrication techniques that we describe enable a 10–20 fold improvement in force resolution or measurement bandwidth over prior piezoresistive cantilevers of comparable thickness. PMID:23175616

  1. Effective bandwidth guaranteed routing schemes for MPLS traffic engineering

    NASA Astrophysics Data System (ADS)

    Wang, Bin; Jain, Nidhi

    2001-07-01

    In this work, we present online algorithms for dynamic routing bandwidth guaranteed label switched paths (LSPs) where LSP set-up requests (in terms of a pair of ingress and egress routers as well as its bandwidth requirement) arrive one by one and there is no a priori knowledge regarding future LSP set-up requests. In addition, we consider rerouting of LSPs in this work. Rerouting of LSPs has not been well studied in previous work on LSP routing. The need of LSP rerouting arises in a number of ways: occurrence of faults (link and/or node failures), re-optimization of existing LSPs' routes to accommodate traffic fluctuation, requests with higher priorities, and so on. We formulate the bandwidth guaranteed LSP routing with rerouting capability as a multi-commodity flow problem. The solution to this problem is used as the benchmark for comparing other computationally less costly algorithms studied in this paper. Furthermore, to more efficiently utilize the network resources, we propose online routing algorithms which route bandwidth demands over multiple paths at the ingress router to satisfy the customer requests while providing better service survivability. Traffic splitting and distribution over the multiple paths are carefully handled using table-based hashing schemes while the order of packets within a flow is preserved. Preliminary simulations are conducted to show the performance of different design choices and the effectiveness of the rerouting and multi-path routing algorithms in terms of LSP set-up request rejection probability and bandwidth blocking probability.

  2. In Vivo 17β-Estradiol Treatment Contributes to Podocyte Actin Stabilization in Female db/db Mice

    PubMed Central

    Fornoni, Alessia; Pereira-Simon, Simone; Wu, Fayi; Burnstein, Kerry L.; Xia, Xiaomei; Conti, Francesco; Lenzi, Andrea; Elliot, Sharon

    2012-01-01

    We recently showed that 17β-estradiol (E2) treatment ameliorated type 2 diabetic glomerulosclerosis in mice in part by protecting podocyte structure and function. Progressive podocyte damage is characterized by foot process effacement, vacuolization, detachment of podocytes from the glomerular basement membrane, and apoptosis. In addition, podocytes are highly dependent on the preservation of their actin cytoskeleton to ensure proper function and survival. Because E2 administration prevented podocyte damage in our study on diabetic db/db mice and has been shown to regulate both actin cytoskeleton and apoptosis in other cell types and tissues, we investigated whether actin remodeling and apoptosis were prevented in podocytes isolated from E2-treated diabetic db/db mice. We performed G-actin/F-actin assays, Western analysis for Hsp25 expression, Ras-related C3 botulinum toxin substrate 1 (Rac1) activity, and apoptosis assays on previously characterized podocytes isolated from both in vivo-treated placebo and E2 female db/db mice. We found that in vivo E2 protects against a phenotype change in the cultured podocytes characterized by a percent increase of F-actin vs. G-actin, suppression of Hsp25 expression and transcriptional activation, increase of Rac1 activity, and decreased apoptotic intermediates. We conclude from these studies that E2 treatment protects against podocyte damage and may prevent/reduce diabetes-induced kidney disease. PMID:23070549

  3. Adaptive Broadcasting Mechanism for Bandwidth Allocation in Mobile Services

    PubMed Central

    Horng, Gwo-Jiun; Wang, Chi-Hsuan; Chou, Chih-Lun

    2014-01-01

    This paper proposes a tree-based adaptive broadcasting (TAB) algorithm for data dissemination to improve data access efficiency. The proposed TAB algorithm first constructs a broadcast tree to determine the broadcast frequency of each data and splits the broadcast tree into some broadcast wood to generate the broadcast program. In addition, this paper develops an analytical model to derive the mean access latency of the generated broadcast program. In light of the derived results, both the index channel's bandwidth and the data channel's bandwidth can be optimally allocated to maximize bandwidth utilization. This paper presents experiments to help evaluate the effectiveness of the proposed strategy. From the experimental results, it can be seen that the proposed mechanism is feasible in practice. PMID:25057509

  4. Gain/bandwidth predictions for travelling-wave gyrotron

    NASA Astrophysics Data System (ADS)

    Sangster, A. J.

    1980-10-01

    Small signal gain computations based on a Pierce description of the traveling-wave gyrotron have been performed for cases involving beam voltages in the range 70-300 kV. Interactions at both the first and the second harmonics of the cyclotron resonance frequency have been considered in order to identify a range of operating parameters for the gyro-traveling-wave amplifier configuration which will potentially produce gain and bandwidth figures of significance to radar and communication systems operating at millimeter-wave frequencies. It is shown that when operated fundamentally and well away from cutoff, the gyro-traveling-wave amplifier can be magnetically tuned over a wide frequency range, with instantaneous bandwidths in the range 4-8% depending on the beam voltage; at voltages in excess of 200 kV, instantaneous bandwidths approaching 10% can be achieved.

  5. Delivery of very high bandwidth with ATM switches and SONET

    SciTech Connect

    Gossage, S.A.

    1993-08-01

    To deliver high bandwidth, a ubiquitous inter-/intra-building cable plant consisting of single mode and multimode fiber as well as twisted pair copper is required. The selection of the ``glue`` to transport and interconnect distributed LANs with central facility resources over a pervasive cable plant is the focus of this paper. A description of the traditional problems that must be overcome to provide very high bandwidth beyond the narrow confines of a computer center is given. The applicability of Asynchronous Transfer Mode (ATM) switching (interconnection) and Synchronous Optical NETwork (SONET) (transport) for high bandwidth delivery is described using the environment and requirements of Sandia National Laboratories. Other methods for distributing high data rates are compared and contrasted. Sandia is implementing a standards based foundation utilizing a pervasive single mode fiber cable plant, SONET transport, and ATM switching to meet the goals of gigabit networking.

  6. Adaptive broadcasting mechanism for bandwidth allocation in mobile services.

    PubMed

    Horng, Gwo-Jiun; Wang, Chi-Hsuan; Chou, Chih-Lun

    2014-01-01

    This paper proposes a tree-based adaptive broadcasting (TAB) algorithm for data dissemination to improve data access efficiency. The proposed TAB algorithm first constructs a broadcast tree to determine the broadcast frequency of each data and splits the broadcast tree into some broadcast wood to generate the broadcast program. In addition, this paper develops an analytical model to derive the mean access latency of the generated broadcast program. In light of the derived results, both the index channel's bandwidth and the data channel's bandwidth can be optimally allocated to maximize bandwidth utilization. This paper presents experiments to help evaluate the effectiveness of the proposed strategy. From the experimental results, it can be seen that the proposed mechanism is feasible in practice.

  7. Correlation and image compression for limited-bandwidth CCD.

    SciTech Connect

    Thompson, Douglas G.

    2005-07-01

    As radars move to Unmanned Aerial Vehicles with limited-bandwidth data downlinks, the amount of data stored and transmitted with each image becomes more significant. This document gives the results of a study to determine the effect of lossy compression in the image magnitude and phase on Coherent Change Detection (CCD). We examine 44 lossy compression types, plus lossless zlib compression, and test each compression method with over 600 CCD image pairs. We also derive theoretical predictions for the correlation for most of these compression schemes, which compare favorably with the experimental results. We recommend image transmission formats for limited-bandwidth programs having various requirements for CCD, including programs which cannot allow performance degradation and those which have stricter bandwidth requirements at the expense of CCD performance.

  8. Maximum bandwidth snapshot channeled imaging polarimeter with polarization gratings

    NASA Astrophysics Data System (ADS)

    LaCasse, Charles F.; Redman, Brian J.; Kudenov, Michael W.; Craven, Julia M.

    2016-05-01

    Compact snapshot imaging polarimeters have been demonstrated in literature to provide Stokes parameter estimations for spatially varying scenes using polarization gratings. However, the demonstrated system does not employ aggressive modulation frequencies to take full advantage of the bandwidth available to the focal plane array. A snapshot imaging Stokes polarimeter is described and demonstrated through results. The simulation studies the challenges of using a maximum bandwidth configuration for a snapshot polarization grating based polarimeter, such as the fringe contrast attenuation that results from higher modulation frequencies. Similar simulation results are generated and compared for a microgrid polarimeter. Microgrid polarimeters are instruments where pixelated polarizers are superimposed onto a focal plan array, and this is another type of spatially modulated polarimeter, and the most common design uses a 2x2 super pixel of polarizers which maximally uses the available bandwidth of the focal plane array.

  9. A new bandwidth compression system of picture signals - The TAT

    NASA Astrophysics Data System (ADS)

    Tanimoto, M.; Chiba, N.; Yasui, H.; Murakami, M.

    A new bandwidth compression system of picture signals called the Time-Axis Transform (TAT) system is presented. It can be applied to the various fields of transmission and recording of picture signals such as the satellite broadcast of high-definition televison. The TAT compresses the bandwidth by reducing the number of transmitted pixels. The transmitted pixels consist of two kinds of pixels: the basic pixels and the additional pixels. The location of the former is fixed and that of the latter varies from picture to picture to minimize the interpolation error in the reconstructed picture. It compresses the bandwidth of the picture signal to one half or less, keeping high picture quality. Both the average power and the peak value of the distortion due to the interpolation error of the deleted pixels are greatly improved.

  10. 'Water window' sources: Selection based on the interplay of spectral properties and multilayer reflection bandwidth

    SciTech Connect

    Li, Bowen; Dunne, Padraig; O'Sullivan, Gerry; Higashiguchi, Takeshi; Otsuka, Takamitsu; Jiang, Weihua; Endo, Akira

    2013-01-28

    Development of laser-produced plasma 'water window' sources poses a major challenge in x-ray research and most effort has focused on line sources for use with zone plate optics. Here, a comparison of carbon and nitrogen line emission with that from both 3d - 4f and 4d - 4f unresolved transition arrays shows that, at power densities available from 'table-top' solid-state lasers, 3d - 4f emission from zirconium plasmas is most intense, and calculations show that in an imaging system based on multilayer mirrors, for reflectance bandwidths >1% has superior performance than either line or broader-band sources. For bandwidths <1%, line sources are preferable.

  11. 47 CFR 74.462 - Authorized bandwidth and emissions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Authorized bandwidth(kHz) Maximum frequency deviation 1 (kHz) Type of emission 2 MHz: 25.87 to 26.0326.07 to....8625 25-50 10 450.900, 450.950 455.900, 455.950 50-100 35 1 Applies where F1A, F1B, F1D, F1E, F2A, F2B... aircraft, or to use a bandwidth in excess of 30 kHz and maximum deviation exceeding 5 kHz 4 For...

  12. Large bandwidth mode order converter by differential waveguides.

    PubMed

    Oner, B B; Üstün, K; Kurt, H; Okyay, A K; Turhan-Sayan, G

    2015-02-01

    In this article, we propose a large bandwidth mode-order converter design by dielectric waveguides with equal lengths but different cross-sectional areas. The efficient conversion between even and odd modes is verified by inducing required phase difference between the equal length waveguides of different widths. Y-junctions are composed of both tapered mode splitter and combiner to connect mono-mode waveguide to multi-mode waveguide. The converted mode profiles at the output port show that the device operates successfully at designed wavelengths with wide bandwidth. This study provides a novel technique to implement compact mode order converters and direction selective/sensitive photonic structures.

  13. A meta-substrate to enhance the bandwidth of metamaterials.

    PubMed

    Chen, Hongsheng; Wang, Zuojia; Zhang, Runren; Wang, Huaping; Lin, Shisheng; Yu, Faxin; Moser, Herbert O

    2014-06-12

    We propose the concept of a meta-substrate to broaden the bandwidth of left-handed metamaterials. The meta-substrate, which behaves like an inhomogeneous magnetic substrate, is composed of another kind of magnetic metamaterials like metallic closed rings. When conventional metamaterial rings are printed on this kind of meta-substrate in a proper way, the interaction of the metamaterials units can be greatly enhanced, yielding an increased bandwidth of negative permeability. An equivalent circuit analytical model is used to quantitatively characterize this phenomenon. Both numerical and experimental demonstrations are carried out, showing good agreement with theoretical predictions.

  14. Programmable bandwidth management in software-defined EPON architecture

    NASA Astrophysics Data System (ADS)

    Li, Chengjun; Guo, Wei; Wang, Wei; Hu, Weisheng; Xia, Ming

    2016-07-01

    This paper proposes a software-defined EPON architecture which replaces the hardware-implemented DBA module with reprogrammable DBA module. The DBA module allows pluggable bandwidth allocation algorithms among multiple ONUs adaptive to traffic profiles and network states. We also introduce a bandwidth management scheme executed at the controller to manage the customized DBA algorithms for all date queues of ONUs. Our performance investigation verifies the effectiveness of this new EPON architecture, and numerical results show that software-defined EPONs can achieve less traffic delay and provide better support to service differentiation in comparison with traditional EPONs.

  15. Search-Free Codebook Mapping for Artificial Bandwidth Extension

    NASA Astrophysics Data System (ADS)

    Park, Heewan; Yoon, Byungsik; Kang, Sangwon; Spanias, Andreas

    A new codebook mapping algorithm for artificial bandwidth extension (ABE) is introduced in this paper. We design a wideband line spectrum pair (LSP) codebook which is coupled with the same index as the LSP codebook of a narrowband speech codec. The received narrowband LSP codebook indices are used to directly induce wideband LSP codewords. Thus, the proposed scheme eliminates codebook search processing to estimate the wideband spectrum envelope. We apply the proposed scheme to bandwidth extension in adaptive multi-rate (AMR) compressed domain. Its performance is assessed via the perceptual evaluation of speech quality (PESQ), informal listening tests, and weighted million operations per second (WMOPS) calculations.

  16. TDX: A high-bandwidth crossbar-switched communication paradigm

    SciTech Connect

    Pierce, P.E.; Eilers, D.L.; Schreiber, A.L.

    1994-08-01

    Digital signal processing systems under development today require scalable and reconfigurable high bandwidth communication resources between processing elements. Shared memory architectures require the ability to transfer data from one processor node to another, as well as maintaining data coherency such as provided by the Scalable Coherent Interface (SCI). Signal processing systems that must move large amounts of data between processor nodes, are best served by a communication system that allows reconfigurable streams of data to flow at deterministic rates with minimal overhead. A Time Domain Crossbar (TDX) communication system providing scalable, programmable, high-bandwidth, streaming communication has been developed and is described in this paper.

  17. A meta-substrate to enhance the bandwidth of metamaterials

    PubMed Central

    Chen, Hongsheng; Wang, Zuojia; Zhang, Runren; Wang, Huaping; Lin, Shisheng; Yu, Faxin; Moser, Herbert O.

    2014-01-01

    We propose the concept of a meta-substrate to broaden the bandwidth of left-handed metamaterials. The meta-substrate, which behaves like an inhomogeneous magnetic substrate, is composed of another kind of magnetic metamaterials like metallic closed rings. When conventional metamaterial rings are printed on this kind of meta-substrate in a proper way, the interaction of the metamaterials units can be greatly enhanced, yielding an increased bandwidth of negative permeability. An equivalent circuit analytical model is used to quantitatively characterize this phenomenon. Both numerical and experimental demonstrations are carried out, showing good agreement with theoretical predictions. PMID:24919678

  18. A hardware preprocessor for use in speech recognition: Speech Input Device SID3

    NASA Astrophysics Data System (ADS)

    Renger, R. E.; Manning, D. R.

    1983-05-01

    A device which reduces the amount of data sent to the computer for speech recognition, by extracting from the speech signal the information that conveys the meaning of the speech, all other data being discarded is presented. The design includes signal to noise ratios as low as 10 dB, public telephone frequency bandwidth and unconstrained speech. It produces continuously at its output 64 bits of digital information, which represents the way 16 speech parameters vary. The parameters cover speech quality, voice pitch, resonant frequency, level of resonance and unvoiced spectrum color. The receiving computer must have supporting software containing recognition algorithms adapted to SID3 parameters.

  19. PASSBY(with FitToDB)

    2002-08-28

    The PASSBY program is used to operate the Sensor for Measurement and analysis of radiation transients (SMART). The unit records triggers an "Event" upon detecting an increase in count rate recorded with a sodium iodide gamma-ray spectrometer. Background radiation levels are monitored continuously and background spectra are updated at 60 second intervals if no radiation sources are present other than those in the natural background. the system accepts input from an optional neutron counter. Inmore » addition to spectral information, the location, determined with an internal GPS and the compass bearing are reported via either an RF modem or a serial cable. The gamma-ray spectra are analyzed to determine which isotopes are present and confidence levels are assigned. The analysis is performed using the FitToDB algorithm, is described as follows. The automatic identification algorithm FitToDB algorithm enables the automatic identification of gamma-ry emitting isotopes in shielded sources. FitToDB can identify combinations of up to ten isotopes, each of which may be viewed through different shielding materials. The algorithm runs rapidly (within about 3 seconds on a 100 MHz Pentium-class processor), and can be compiled to run both DOS and Windows operating systems. Computational speed and system interoperability issues are addressed by the approach of interpolating spectra from an existing database of computed templates rather than performing detector response functions calculations within the algorithm.« less

  20. Excellent electromagnetic absorption properties of poly(3,4-ethylenedioxythiophene)-reduced graphene oxide-Co3O4 composites prepared by a hydrothermal method.

    PubMed

    Liu, Pan-Bo; Huang, Ying; Sun, Xu

    2013-12-11

    The ternary composites of poly(3,4-ethylenedioxythiophene)-reduced graphene oxide-Co3O4 (PEDOT-RGO-Co3O4) were synthesized and the electromagnetic absorption property of the composites was investigated. The structure of the composites was characterized with Fourier-transform infrared spectra, X-ray diffraction, Raman spectroscopy, X-ray photoelectron spectroscopy, and transmission electron microscope. The electromagnetic parameters indicate the enhanced electromagnetic absorption property of the composites was attributed to the better impedance matching. On the basis of the above characterization, an electromagnetic complementary theory was proposed to explain the impedance matching. It can be found that the maximum reflection loss of PEDOT-RGO-Co3O4 can reach -51.1 dB at 10.7 GHz, and the bandwidth exceeding -10 dB is 3.1 GHz with absorber thickness of 2.0 mm. Therefore, the PEDOT-RGO-Co3O4 composites, with such excellent electromagnetic absorption properties and wide absorption bandwidth, can be used as a new kind of candidate for microwave absorbing materials. PMID:24218981

  1. C-band superconductor/semiconductor hybrid field-effect transistor amplifier on a LaAlO3 substrate

    NASA Technical Reports Server (NTRS)

    Nahra, J. J.; Bhasin, K. B.; Toncich, S. S.; Subramanyam, G.; Kapoor, V. J.

    1992-01-01

    A single-stage C-band superconductor/semiconductor hybrid field-effect transistor amplifier was designed, fabricated, and tested at 77 K. The large area (1 inch x 0.5 inches) high temperature superconducting Tl-Ba-Ca-Cu-O (TBCCO) thin film was rf magnetron sputtered onto a LaAlO3 substrate. The film had a transition temperature of about 92 K after it was patterned and etched. The amplifier showed a gain of 6 dB and a 3 dB bandwidth of 100 MHz centered at 7.9 GHz. An identical gold amplifier circuit was tested at 77 K, and these results are compared with those from the hybrid amplifier.

  2. 47 CFR 2.1049 - Measurements required: Occupied bandwidth.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... exceed the modulation reference level by the number of decibels determined using the appropriate formula... as follows. For single sideband and independent sideband transmitters, the input level of the... level 16 dB greater than that necessary to produce 50 percent modulation. The input level shall...

  3. A Higher Bandwidth Servo Design for Magnetic Disk Drives: A Head-positioning Control System with Strain Feedback Control

    NASA Astrophysics Data System (ADS)

    Nakagawa, Shinsuke; Yamaguchi, Takashi

    In magnetic disk drives, mechanical resonance modes prevent a higher bandwidth servo being used for head positioning control. To overcome this limitation and realize more precise head positioning, a strain feedback controller which is added to a conventional head-position feedback loop was developed. The controller of a strain-feedback control system was designed so that the gain and the phase delay of the sensitivity function of the strain-feedback control system were both reduced below the frequency of a primary mechanical resonance. The controller achieves gain suppression by about 10dB at a primary mechanical resonance and phase delay of about zero degrees. It was found that the head-position control system (i.e., the strain feedback plus the conventional head-position feedback loop) increases the servo bandwidth by 17% and improves the positioning accuracy by 18%. It was also confirmed that unlike conventional servo system, the new servo design does not suffer degradation of servo characteristics at high temperature.

  4. Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates diabetes-induced renal damage through the advanced glycation end product-related pathway in db/db mice.

    PubMed

    Park, Chan Hum; Yokozawa, Takako; Noh, Jeong Sook

    2014-08-01

    This study was conducted to examine whether oligonol, a low-molecular-weight polyphenol derived from lychee fruit, has an ameliorative effect on diabetes-induced alterations, such as advanced glycation end product (AGE) formation or apoptosis in the kidneys of db/db mice with type 2 diabetes. Oligonol [10 or 20 mg/(kg body weight · d), orally] was administered every day for 8 wk to prediabetic db/db mice, and its effect was compared with vehicle-treated db/db and normal control mice (m/m). The administration of oligonol decreased the elevated renal glucose concentrations and reactive oxygen species in db/db mice (P < 0.05). The increased serum urea nitrogen and creatinine concentrations, which reflect renal dysfunction in db/db mice, were substantially lowered by oligonol. Oligonol reduced renal protein expression of NAD(P)H oxidase subunits (p22 phagocytic oxidase and NAD(P)H oxidase-4), AGEs (except for pentosidine), and c-Jun N-terminal kinase B-targeting proinflammatory tumor necrosis factor-α (P < 0.05). Oligonol improved the expressions of antiapoptotic [B-cell lymphoma protein 2 (Bcl-2) and survivin] and proapoptotic [Bcl-2-associated X protein, cytochrome c, and caspase-3] proteins in the kidneys of db/db mice (P < 0.05). In conclusion, these results provide important evidence that oligonol exhibits a pleiotropic effect on AGE formation and apoptosis-related variables, representing renoprotective effects against the development of diabetic complications in db/db mice with type 2 diabetes.

  5. Beneficial effect of the soluble guanylyl cyclase stimulator BAY 41-2272 on impaired penile erection in db/db-/- type II diabetic and obese mice.

    PubMed

    Nunes, Kenia Pedrosa; Teixeira, Cleber E; Priviero, Fernanda B M; Toque, Haroldo A; Webb, R Clinton

    2015-05-01

    Type 2 diabetes mellitus (DM2) and obesity are major risk factors for erectile dysfunction (ED). In diabetes, increased oxidative stress leads to decreased nitric oxide (NO) bioavailability, and diabetic patients appear to be less responsive to conventional therapy with phosphodiesterase type 5 inhibitors. We investigated whether the soluble guanylyl cyclase stimulator BAY 41-2272 (5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridine-3-yl]pyrimidin-4ylamine) is effective in improving impaired corpus cavernosum (CC) relaxation in obese DM2 mice by reducing oxidative stress. Adult db/db(-/-) mice or their lean db(/+) littermates were used to assess vascular function, cGMP levels, antioxidant status, NADPH oxidase expression, and superoxide formation in the absence or presence of BAY 41-2272. Results showed that BAY 41-2272 (10(-8) to 10(-5) M) potently relaxed CC from db(/+) or db/db(-/-) mice in a similar manner. BAY 41-2272 significantly enhanced both endothelium-dependent and nitrergic relaxation induced by electrical field stimulation (EFS), and improved the impaired relaxation to acetylcholine and EFS in the diabetic animals in a concentration-dependent manner (10(-8) to 10(-7) M). BAY 41-2272 increased cGMP levels and potentiated relaxation responses to exogenous NO in CC. Total antioxidant status was reduced in plasma and urine whereas expression of vascular NADPH oxidase subunits (gp91phox, p22phox, and p47phox) was increased in the CC of db/db(-/-) mice, suggesting a state of oxidative stress. These effects were prevented by BAY 41-2272 in a concentration-dependent manner. These results suggest that BAY 41-2272 improves CC relaxation in db/db(-/-) mice by increasing cGMP and augmenting antioxidant status, making this drug is a potential novel candidate to treat ED.

  6. 47 CFR 74.1236 - Emission and bandwidth.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Emission and bandwidth. 74.1236 Section 74.1236 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) BROADCAST RADIO SERVICES EXPERIMENTAL RADIO, AUXILIARY, SPECIAL BROADCAST AND OTHER PROGRAM DISTRIBUTIONAL SERVICES FM Broadcast Translator Stations...

  7. 47 CFR 101.515 - Emissions and bandwidth.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false Emissions and bandwidth. 101.515 Section 101.515 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.515 Emissions...

  8. 47 CFR 101.515 - Emissions and bandwidth.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Emissions and bandwidth. 101.515 Section 101.515 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES FIXED MICROWAVE SERVICES 24 GHz Service and Digital Electronic Message Service § 101.515 Emissions...

  9. Limits in motor control bandwidth during stick balancing.

    PubMed

    Reeves, N Peter; Pathak, Pramod; Popovich, John M; Vijayanagar, Vilok

    2013-05-01

    Why can we balance a yardstick but not a pencil on the tip of our finger? As with other physical systems, human motor control has constraints, referred to as bandwidth, which restricts the range of frequency over which the system can operate within some tolerated level of error. To investigate control bandwidth, the natural frequency of a stick used during a stick-balancing task was modified by adjusting the height of a mass attached to the stick. The ability to successfully balance the stick with the mass positioned at four different heights was determined. In addition, electromyographic signals from forearm and trunk muscles were recorded during the trials. We hypothesized that 1) the probability of successfully balancing would decrease as mass height decreased; and 2) the level of muscle activation in both agonist and antagonist would increase as the natural frequency of the stick increased. Results showed that as the mass height decreased the probability of successfully balancing the stick decreased. Changes in the probability of success with respect to mass height showed a threshold effect, suggesting that limits in human control bandwidth were approached at the lowest mass height. Also, the level of muscle activation in both the agonist and antagonist of the forearm and trunk increased linearly as the natural frequency of the stick increased. These changes in muscle activation suggest that the central nervous system adapts muscle activation to task dynamics, possibly to improve control bandwidth.

  10. Numerical Models of Broad Bandwidth Nanosecond Optical Parametric Oscillators

    SciTech Connect

    Bowers, M.S.; Gehr, R.J.; Smith, A.V.

    1998-10-14

    We describe results from three new methods of numerically modeling broad-bandwidth, nanosecond OPO's in the plane-wave approximate ion. They account for differences in group velocities among the three mixing waves, and also include a qutt~ttun noise model.

  11. 47 CFR 2.1049 - Measurements required: Occupied bandwidth.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Measurements required: Occupied bandwidth. 2.1049 Section 2.1049 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL FREQUENCY ALLOCATIONS AND RADIO TREATY MATTERS; GENERAL RULES AND REGULATIONS Equipment Authorization Procedures Certification § 2.1049 Measurements required:...

  12. Bandwidth utilization maximization of scientific RF communication systems

    SciTech Connect

    Rey, D.; Ryan, W.; Ross, M.

    1997-01-01

    A method for more efficiently utilizing the frequency bandwidth allocated for data transmission is presented. Current space and range communication systems use modulation and coding schemes that transmit 0.5 to 1.0 bits per second per Hertz of radio frequency bandwidth. The goal in this LDRD project is to increase the bandwidth utilization by employing advanced digital communications techniques. This is done with little or no increase in the transmit power which is usually very limited on airborne systems. Teaming with New Mexico State University, an implementation of trellis coded modulation (TCM), a coding and modulation scheme pioneered by Ungerboeck, was developed for this application and simulated on a computer. TCM provides a means for reliably transmitting data while simultaneously increasing bandwidth efficiency. The penalty is increased receiver complexity. In particular, the trellis decoder requires high-speed, application-specific digital signal processing (DSP) chips. A system solution based on the QualComm Viterbi decoder and the Graychip DSP receiver chips is presented.

  13. 47 CFR 74.535 - Emission and bandwidth.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... bandwidth: As specified by the following equation but in no event less than 50 decibels: A = 35 + 0.8(G − 50) + 10 Log10 B. (Attenuation greater than 80 decibels is not required.) Where: A = Attenuation (in decibels) below the mean output power level. G = Percent removed from the carrier frequency. B =...

  14. Terahertz bandwidth RF spectrum analysis of femtosecond pulses using a chalcogenide chip.

    PubMed

    Pelusi, M D; Vo, T D; Luan, F; Madden, S J; Choi, D-Y; Bulla, D A P; Luther-Davies, B; Eggleton, B J

    2009-05-25

    We report the first demonstration of the use of an RF spectrum analyser with multi-terahertz bandwidth to measure the properties of femtosecond optical pulses. A low distortion and broad measurement bandwidth of 2.78 THz (nearly two orders of magnitude greater than conventional opto-electronic analyzers) was achieved by using a 6 cm long As(2)S(3) chalcogenide waveguide designed for high Kerr nonlinearity and near zero dispersion. Measurements of pulses as short as 260 fs produced from a soliton-effect compressor reveal features not evident from the pulse's optical spectrum. We also applied an inverse Fourier transform numerically to the captured data to re-construct a time-domain waveform that resembled pulse measurement obtained from intensity autocorrelation. PMID:19466183

  15. Invariant bandwidth of erbium in ZnO-PbO-tellurite glasses: Local probe/model

    SciTech Connect

    Ramamoorthy, Raj Kumar; Bhatnagar, Anil K.

    2014-04-24

    A series of [(70TeO{sub 2}−(30−x)ZnO−xPbO){sub 0.99}−(Er{sub 2}O{sub 3}){sub 0.01}; where x = 5, 10, 15 and 20] tellurite glasses, were prepared using the melt quenching technique. Crucial emission bandwidth of erbium at 1.5 μm has been derived and found to be the same for all the glasses, irrespective of PbO content. This identical bandwidth in all tellurite glasses is attributed to the presence of erbium in tellurium rich disordered environments. This result has been complemented through XANES spectra and the obtained invariant first shell of 6.5 oxygen atoms, confirm the unchanged environment in these glasses for all PbO content.

  16. Rapamycin Increases Mortality in db/db Mice, a Mouse Model of Type 2 Diabetes.

    PubMed

    Sataranatarajan, Kavithalakshmi; Ikeno, Yuji; Bokov, Alex; Feliers, Denis; Yalamanchili, Himabindu; Lee, Hak Joo; Mariappan, Meenalakshmi M; Tabatabai-Mir, Hooman; Diaz, Vivian; Prasad, Sanjay; Javors, Martin A; Ghosh Choudhury, Goutam; Hubbard, Gene B; Barnes, Jeffrey L; Richardson, Arlan; Kasinath, Balakuntalam S

    2016-07-01

    We examined the effect of rapamycin on the life span of a mouse model of type 2 diabetes, db/db mice. At 4 months of age, male and female C57BLKSJ-lepr (db/db) mice (db/db) were placed on either a control diet, lacking rapamycin or a diet containing rapamycin and maintained on these diets over their life span. Rapamycin was found to reduce the life span of the db/db mice. The median survival of male db/db mice fed the control and rapamycin diets was 349 and 302 days, respectively, and the median survival of female db/db mice fed the control and rapamycin diets was 487 and 411 days, respectively. Adjusting for gender differences, rapamycin increased the mortality risk 1.7-fold in both male and female db/db mice. End-of-life pathological data showed that suppurative inflammation was the main cause of death in the db/db mice, which is enhanced slightly by rapamycin treatment.

  17. A system-level bandwidth design method for wormhole network-on-chip

    NASA Astrophysics Data System (ADS)

    Wang, Jian; Li, Yubai; Liao, Changjun

    2016-11-01

    To improve the Network-on-Chip (NoC) performance, we propose a system-level bandwidth design method customising the bandwidths of the NoC links. In details, we first built a mathematical model to catch the relationship between the NoC commutation latency and the NoC link bandwidth, and then develop a bandwidth allocation algorithm to automatically optimise the bandwidth for each NoC link. The experimental results show that our bandwidth-customising method improves the NoC performance compared to the traditional uniform bandwidth allocation method. Besides, it can also make our NoC to achieve the same communication performance level as the uniform bandwidth NoC but using fewer bandwidth resources, which is beneficial to save the NoC area and power.

  18. Investigation of the effects of bandwidth and time delay on helicopter roll-axis handling qualities

    NASA Technical Reports Server (NTRS)

    Pausder, Heinz-Juergen; Blanken, Chris L.

    1993-01-01

    Several years of cooperative research conducted under the U.S./German Memorandum of Understanding (MOU) in helicopter flight control has recently resulted in a successful handling qualities study. The focus of this cooperative research has been the effects on handling qualities due to time delays in combination with a high bandwidth vehicle. The jointly performed study included the use of U.S. ground-based simulation and German in-flight simulation facilities. The NASA-Ames Vertical Motion Simulator (VMS) was used to develop a high bandwidth slalom tracking task which took into consideration the constraints of the facilities. The VMS was also used to define a range of the test parameters and to perform initial handling qualities evaluations. The flight tests were conducted using DLR's variable-stability BO 105 S3 Advanced Technology Testing Helicopter System (ATTHeS). Configurations included a rate command and an attitude command response system with added time delays up to 160 milliseconds over the baseline and bandwidth values between 1.5 and 4.5 rad/sec. Sixty-six evaluations were performed in about 25 hours of flight time during ten days of testing. The results indicate a need to more tightly constrain the allowable roll axis phase delay for the Level 1 and Level 2 requirements in the U.S. Army's specification for helicopter handling qualities, ADS-33C.

  19. Pulse Shaped 8-PSK Bandwidth Efficiency and Spectral Spike Elimination

    NASA Technical Reports Server (NTRS)

    Tao, Jian-Ping

    1998-01-01

    The most bandwidth-efficient communication methods are imperative to cope with the congested frequency bands. Pulse shaping methods have excellent effects on narrowing bandwidth and increasing band utilization. The position of the baseband filters for the pulse shaping is crucial. Post-modulation pulse shaping (a low pass filter is located after the modulator) can change signals from constant envelope to non-constant envelope, and non-constant envelope signals through non-linear device (a SSPA or TWT) can further spread the power spectra. Pre-modulation pulse shaping (a filter is located before the modulator) will have constant envelope. These two pulse shaping methods have different effects on narrowing the bandwidth and producing bit errors. This report studied the effect of various pre-modulation pulse shaping filters with respect to bandwidth, spectral spikes and bit error rate. A pre-modulation pulse shaped 8-ary Phase Shift Keying (8PSK) modulation was used throughout the simulations. In addition to traditional pulse shaping filters, such as Bessel, Butterworth and Square Root Raised Cosine (SRRC), other kinds of filters or pulse waveforms were also studied in the pre-modulation pulse shaping method. Simulations were conducted by using the Signal Processing Worksystem (SPW) software package on HP workstations which simulated the power spectral density of pulse shaped 8-PSK signals, end to end system performance and bit error rates (BERS) as a function of Eb/No using pulse shaping in an AWGN channel. These results are compared with the post-modulation pulse shaped 8-PSK results. The simulations indicate traditional pulse shaping filters used in pre-modulation pulse shaping may produce narrower bandwidth, but with worse BER than those in post-modulation pulse shaping. Theory and simulations show pre- modulation pulse shaping could also produce discrete line power spectra (spikes) at regular frequency intervals. These spikes may cause interference with adjacent

  20. New fabrication techniques for ring-array transducers for real-time 3D intravascular ultrasound.

    PubMed

    Light, Edward D; Lieu, Victor; Smith, Stephen W

    2009-10-01

    We have previously described miniature 2D array transducers integrated into a Cook Medical, Inc. vena cava filter deployment device. While functional, the fabrication technique was very labor intensive and did not lend itself well to efficient fabrication of large numbers of devices. We developed two new fabrication methods that we believe can be used to efficiently manufacture these types of devices in greater than prototype numbers. One transducer consisted of 55 elements operating near 5 MHz. The interelement spacing is 0.20 mm. It was constructed on a flat piece of copper-clad polyimide and then wrapped around an 11 French catheter of a Cook Medical, Inc. inferior vena cava (IVC) filter deployment device. We used a braided wiring technology from Tyco Electronics Corp. to connect the elements to our real-time 3D ultrasound scanner. Typical measured transducer element bandwidth was 20% centered at 4.7 MHz and the 50 Omega round trip insertion loss was --82 dB. The mean of the nearest neighbor cross talk was -37.0 dB. The second method consisted of a 46-cm long single layer flex circuit from MicroConnex that terminates in an interconnect that plugs directly into our system cable. This transducer had 70 elements at 0.157 mm interelement spacing operating at 4.8 MHz. Typical measured transducer element bandwidth was 29% and the 50 Omega round trip insertion loss was -83 dB. The mean of the nearest neighbor cross talk was -33.0 dB. PMID:20458877

  1. Optical interconnect technologies for high-bandwidth ICT systems

    NASA Astrophysics Data System (ADS)

    Chujo, Norio; Takai, Toshiaki; Mizushima, Akiko; Arimoto, Hideo; Matsuoka, Yasunobu; Yamashita, Hiroki; Matsushima, Naoki

    2016-03-01

    The bandwidth of information and communication technology (ICT) systems is increasing and is predicted to reach more than 10 Tb/s. However, an electrical interconnect cannot achieve such bandwidth because of its density limits. To solve this problem, we propose two types of high-density optical fiber wiring for backplanes and circuit boards such as interface boards and switch boards. One type uses routed ribbon fiber in a circuit board because it has the ability to be formed into complex shapes to avoid interfering with the LSI and electrical components on the board. The backplane is required to exhibit high density and flexibility, so the second type uses loose fiber. We developed a 9.6-Tb/s optical interconnect demonstration system using embedded optical modules, optical backplane, and optical connector in a network apparatus chassis. We achieved 25-Gb/s transmission between FPGAs via the optical backplane.

  2. Anamorphic transformation and its application to time-bandwidth compression.

    PubMed

    Asghari, Mohammad H; Jalali, Bahram

    2013-09-20

    A general method for compressing the modulation time-bandwidth product of analog signals is introduced. As one of its applications, this physics-based signal grooming, performed in the analog domain, allows a conventional digitizer to sample and digitize the analog signal with variable resolution. The net result is that frequency components that were beyond the digitizer bandwidth can now be captured and, at the same time, the total digital data size is reduced. This compression is lossless and is achieved through a feature selective reshaping of the signal's complex field, performed in the analog domain prior to sampling. Our method is inspired by operation of Fovea centralis in the human eye and by anamorphic transformation in visual arts. The proposed transform can also be performed in the digital domain as a data compression algorithm to alleviate the storage and transmission bottlenecks associated with "big data."

  3. Long-pulse-width narrow-bandwidth solid state laser

    DOEpatents

    Dane, C.B.; Hackel, L.A.

    1997-11-18

    A long pulse laser system emits 500-1000 ns quasi-rectangular pulses at 527 nm with near diffraction-limited divergence and near transform-limited bandwidth. The system consists of one or more flashlamp-pumped Nd:glass zig-zag amplifiers, a very low threshold stimulated-Brillouin-scattering (SBS) phase conjugator system, and a free-running single frequency Nd:YLF master oscillator. Completely passive polarization switching provides eight amplifier gain passes. Multiple frequency output can be generated by using SBS cells having different pressures of a gaseous SBS medium or different SBS materials. This long pulse, low divergence, narrow-bandwidth, multi-frequency output laser system is ideally suited for use as an illuminator for long range speckle imaging applications. Because of its high average power and high beam quality, this system has application in any process which would benefit from a long pulse format, including material processing and medical applications. 5 figs.

  4. Long-pulse-width narrow-bandwidth solid state laser

    DOEpatents

    Dane, C. Brent; Hackel, Lloyd A.

    1997-01-01

    A long pulse laser system emits 500-1000 ns quasi-rectangular pulses at 527 nm with near diffraction-limited divergence and near transform-limited bandwidth. The system consists of one or more flashlamp-pumped Nd:glass zig-zag amplifiers, a very low threshold stimulated-Brillouin-scattering (SBS) phase conjugator system, and a free-running single frequency Nd:YLF master oscillator. Completely passive polarization switching provides eight amplifier gain passes. Multiple frequency output can be generated by using SBS cells having different pressures of a gaseous SBS medium or different SBS materials. This long pulse, low divergence, narrow-bandwidth, multi-frequency output laser system is ideally suited for use as an illuminator for long range speckle imaging applications. Because of its high average power and high beam quality, this system has application in any process which would benefit from a long pulse format, including material processing and medical applications.

  5. Exploiting material softening in hard PZTs for resonant bandwidth enhancement

    NASA Astrophysics Data System (ADS)

    Leadenham, S.; Moura, A.; Erturk, A.

    2016-04-01

    Intentionally designed nonlinearities have been employed by several research groups to enhance the frequency bandwidth of vibration energy harvesters. Another type of nonlinear resonance behavior emerges from the piezoelectric constitutive behavior for high excitation levels and is manifested in the form of softening stiffness. This material nonlinearity does not result in the jump phenomenon in soft piezoelectric ceramics, e.g. PZT-5A and PZT-5H, due to their large internal dissipation. This paper explores the potential for wideband energy harvesting using a hard (relatively high quality factor) PZT-8 bimorph by exploiting its material softening. A wide range of base excitation experiments conducted for a set of resistive electrical loads confirms the frequency bandwidth enhancement.

  6. Bandwidth-sharing in LHCONE, an analysis of the problem

    NASA Astrophysics Data System (ADS)

    Wildish, T.

    2015-12-01

    The LHC experiments have traditionally regarded the network as an unreliable resource, one which was expected to be a major source of errors and inefficiency at the time their original computing models were derived. Now, however, the network is seen as much more capable and reliable. Data are routinely transferred with high efficiency and low latency to wherever computing or storage resources are available to use or manage them. Although there was sufficient network bandwidth for the experiments’ needs during Run-1, they cannot rely on ever-increasing bandwidth as a solution to their data-transfer needs in the future. Sooner or later they need to consider the network as a finite resource that they interact with to manage their traffic, in much the same way as they manage their use of disk and CPU resources. There are several possible ways for the experiments to integrate management of the network in their software stacks, such as the use of virtual circuits with hard bandwidth guarantees or soft real-time flow-control, with somewhat less firm guarantees. Abstractly, these can all be considered as the users (the experiments, or groups of users within the experiment) expressing a request for a given bandwidth between two points for a given duration of time. The network fabric then grants some allocation to each user, dependent on the sum of all requests and the sum of available resources, and attempts to ensure the requirements are met (either deterministically or statistically). An unresolved question at this time is how to convert the users’ requests into an allocation. Simply put, how do we decide what fraction of a network's bandwidth to allocate to each user when the sum of requests exceeds the available bandwidth? The usual problems of any resourcescheduling system arise here, namely how to ensure the resource is used efficiently and fairly, while still satisfying the needs of the users. Simply fixing quotas on network paths for each user is likely to lead

  7. Optical lightpipe as a high-bandwidth fusion diagnostic

    NASA Astrophysics Data System (ADS)

    Moran, M. J.; Lerche, R. A.; Mant, G.; Glebov, V. Yu.; Sangster, T. C.; Mack, J. M.

    2006-10-01

    A recent series of experiments at the University of Rochester Laboratory for Laser Energetics OMEGA facility studied the feasibility of using radiation-to-light converters and high-bandwidth optical signal transmission to remote recording devices as an alternate nuclear diagnostic method. A prototype system included a radiation-to-light converter, a multiple-section lightpipe consisting of stainless steel tubes with polished interiors and turning mirrors, and a streak camera or photomultiplier/digitizer combination for signal recording. Several different radiation-to-light converters (scintillators, glasses, plastics, and pressurized CO2) performed well and produced predictable optical emissions. The lightpipe transmitted high-bandwidth optical signals to the recording stations. Data were recorded with the streak camera, the photomultiplier/digitizer, and with both recorders simultaneously.

  8. The Optical Lightpipe as a High-Bandwidth Fusion Diagnostic

    SciTech Connect

    Moran, M J; Lerche, R A; Mant, G; Glebov, V Y; Sangster, T C; Mack, J M

    2006-07-21

    A recent series of experiments at the University of Rochester Laboratory for Laser Energetics OMEGA facility studied the feasibility of using radiation-to-light converters and high bandwidth optical signal transmission to remote recording devices as an alternate nuclear diagnostic method. A prototype system included a radiation-to-light converter, a multiple-section light pipe consisting of stainless steel tubes with polished interiors and turning mirrors, and a streak camera or photomultiplier/digitizer combination for signal recording. Several different radiation-to-light converters (scintillators, glasses, plastics, and pressurized CO{sub 2}) performed well and produced predictable optical emissions. The lightpipe transmitted high-bandwidth optical signals to the recording stations. Data were recorded with the streak camera, the photomultiplier/digitizer, and with both recorders simultaneously.

  9. Anamorphic transformation and its application to time-bandwidth compression.

    PubMed

    Asghari, Mohammad H; Jalali, Bahram

    2013-09-20

    A general method for compressing the modulation time-bandwidth product of analog signals is introduced. As one of its applications, this physics-based signal grooming, performed in the analog domain, allows a conventional digitizer to sample and digitize the analog signal with variable resolution. The net result is that frequency components that were beyond the digitizer bandwidth can now be captured and, at the same time, the total digital data size is reduced. This compression is lossless and is achieved through a feature selective reshaping of the signal's complex field, performed in the analog domain prior to sampling. Our method is inspired by operation of Fovea centralis in the human eye and by anamorphic transformation in visual arts. The proposed transform can also be performed in the digital domain as a data compression algorithm to alleviate the storage and transmission bottlenecks associated with "big data." PMID:24085172

  10. Bandwidth Study of the Microwave Reflectors with Rectangular Corrugations

    NASA Astrophysics Data System (ADS)

    Zhang, Liang; He, Wenlong; Donaldson, Craig R.; Cross, Adrian W.

    2016-09-01

    The mode-selective microwave reflector with periodic rectangular corrugations in the inner surface of a circular metallic waveguide is studied in this paper. The relations between the bandwidth and reflection coefficient for different numbers of corrugation sections were studied through a global optimization method. Two types of reflectors were investigated. One does not consider the phase response and the other does. Both types of broadband reflectors operating at W-band were machined and measured to verify the numerical simulations.

  11. Bandwidth improvement for germanium photodetector using wire bonding technology.

    PubMed

    Chen, Guanyu; Yu, Yu; Deng, Shupeng; Liu, Lei; Zhang, Xinliang

    2015-10-01

    We demonstrate an ultrahigh speed germanium photodetector by introducing gold wires into the discrete ground electrodes with standard wire bonding technology. To engineer the parasitic parameter, the physical dimension of the gold wire used for wire bonding is specially designed with an inductance of about 450 pH. Simulation and experimental results show that the bandwidth of the photodetector can be effectively extended from less than 30 GHz to over 60 GHz.

  12. Phantom evaluation of stacked-type dual-frequency 1-3 composite transducers: A feasibility study on intracavitary acoustic angiography.

    PubMed

    Kim, Jinwook; Li, Sibo; Kasoji, Sandeep; Dayton, Paul A; Jiang, Xiaoning

    2015-12-01

    In this paper, we present phantom evaluation results of a stacked-type dual-frequency 1-3 piezoelectric composite transducer as a feasibility study for intracavitary acoustic angiography. Our previous design (6.5/30 MHz PMN-PT single crystal transducer) for intravascular contrast ultrasound imaging exhibited a contrast-to-tissue ratio (CTR) of 12 dB with a penetration depth of 2.5 mm. For improved penetration depth (>3 mm) and comparable contrast-to-tissue ratio (>12 dB), we evaluated a lower frequency 2/14 MHz PZT 1-3 composite transducer. Superharmonic imaging performance of this transducer and a detailed characterization of key parameters for acoustic angiography are presented. The 2/14 MHz arrangement demonstrated a -6 dB fractional bandwidth of 56.5% for the transmitter and 41.8% for the receiver, and produced sufficient peak-negative pressures (>1.5 MPa) at 2 MHz to induce a strong nonlinear harmonic response from microbubble contrast agents. In an in-vitro contrast ultrasound study using a tissue mimicking phantom and 200 μm cellulose microvessels, higher harmonic microbubble responses, from the 5th through the 7th harmonics, were detected with a signal-to-noise ratio of 16 dB. The microvessels were resolved in a two-dimensional image with a -6dB axial resolution of 615 μm (5.5 times the wavelength of 14 MHz waves) and a contrast-to-tissue ratio of 16 dB. This feasibility study, including detailed explanation of phantom evaluation and characterization procedures for key parameters, will be useful for the development of future dual-frequency array transducers for intracavitary acoustic angiography. PMID:26112426

  13. Phantom evaluation of stacked-type dual-frequency 1-3 composite transducers: A feasibility study on intracavitary acoustic angiography.

    PubMed

    Kim, Jinwook; Li, Sibo; Kasoji, Sandeep; Dayton, Paul A; Jiang, Xiaoning

    2015-12-01

    In this paper, we present phantom evaluation results of a stacked-type dual-frequency 1-3 piezoelectric composite transducer as a feasibility study for intracavitary acoustic angiography. Our previous design (6.5/30 MHz PMN-PT single crystal transducer) for intravascular contrast ultrasound imaging exhibited a contrast-to-tissue ratio (CTR) of 12 dB with a penetration depth of 2.5 mm. For improved penetration depth (>3 mm) and comparable contrast-to-tissue ratio (>12 dB), we evaluated a lower frequency 2/14 MHz PZT 1-3 composite transducer. Superharmonic imaging performance of this transducer and a detailed characterization of key parameters for acoustic angiography are presented. The 2/14 MHz arrangement demonstrated a -6 dB fractional bandwidth of 56.5% for the transmitter and 41.8% for the receiver, and produced sufficient peak-negative pressures (>1.5 MPa) at 2 MHz to induce a strong nonlinear harmonic response from microbubble contrast agents. In an in-vitro contrast ultrasound study using a tissue mimicking phantom and 200 μm cellulose microvessels, higher harmonic microbubble responses, from the 5th through the 7th harmonics, were detected with a signal-to-noise ratio of 16 dB. The microvessels were resolved in a two-dimensional image with a -6dB axial resolution of 615 μm (5.5 times the wavelength of 14 MHz waves) and a contrast-to-tissue ratio of 16 dB. This feasibility study, including detailed explanation of phantom evaluation and characterization procedures for key parameters, will be useful for the development of future dual-frequency array transducers for intracavitary acoustic angiography.

  14. Managing high-bandwidth real-time data storage

    SciTech Connect

    Bigelow, David D.; Brandt, Scott A; Bent, John M; Chen, Hsing-Bung

    2009-09-23

    There exist certain systems which generate real-time data at high bandwidth, but do not necessarily require the long-term retention of that data in normal conditions. In some cases, the data may not actually be useful, and in others, there may be too much data to permanently retain in long-term storage whether it is useful or not. However, certain portions of the data may be identified as being vitally important from time to time, and must therefore be retained for further analysis or permanent storage without interrupting the ongoing collection of new data. We have developed a system, Mahanaxar, intended to address this problem. It provides quality of service guarantees for incoming real-time data streams and simultaneous access to already-recorded data on a best-effort basis utilizing any spare bandwidth. It has built in mechanisms for reliability and indexing, can scale upwards to meet increasing bandwidth requirements, and handles both small and large data elements equally well. We will show that a prototype version of this system provides better performance than a flat file (traditional filesystem) based version, particularly with regard to quality of service guarantees and hard real-time requirements.

  15. Ultra-high bandwidth quantum secured data transmission

    PubMed Central

    Dynes, James F.; Tam, Winci W-S.; Plews, Alan; Fröhlich, Bernd; Sharpe, Andrew W.; Lucamarini, Marco; Yuan, Zhiliang; Radig, Christian; Straw, Andrew; Edwards, Tim; Shields, Andrew J.

    2016-01-01

    Quantum key distribution (QKD) provides an attractive means for securing communications in optical fibre networks. However, deployment of the technology has been hampered by the frequent need for dedicated dark fibres to segregate the very weak quantum signals from conventional traffic. Up until now the coexistence of QKD with data has been limited to bandwidths that are orders of magnitude below those commonly employed in fibre optic communication networks. Using an optimised wavelength divisional multiplexing scheme, we transport QKD and the prevalent 100 Gb/s data format in the forward direction over the same fibre for the first time. We show a full quantum encryption system operating with a bandwidth of 200 Gb/s over a 100 km fibre. Exploring the ultimate limits of the technology by experimental measurements of the Raman noise, we demonstrate it is feasible to combine QKD with 10 Tb/s of data over a 50 km link. These results suggest it will be possible to integrate QKD and other quantum photonic technologies into high bandwidth data communication infrastructures, thereby allowing their widespread deployment. PMID:27734921

  16. Adaptive bandwidth measurements of importance functions for speech intelligibility prediction

    PubMed Central

    Whitmal, Nathaniel A.; DeRoy, Kristina

    2011-01-01

    The Articulation Index (AI) and Speech Intelligibility Index (SII) predict intelligibility scores from measurements of speech and hearing parameters. One component in the prediction is the “importance function,” a weighting function that characterizes contributions of particular spectral regions of speech to speech intelligibility. Previous work with SII predictions for hearing-impaired subjects suggests that prediction accuracy might improve if importance functions for individual subjects were available. Unfortunately, previous importance function measurements have required extensive intelligibility testing with groups of subjects, using speech processed by various fixed-bandwidth low-pass and high-pass filters. A more efficient approach appropriate to individual subjects is desired. The purpose of this study was to evaluate the feasibility of measuring importance functions for individual subjects with adaptive-bandwidth filters. In two experiments, ten subjects with normal-hearing listened to vowel-consonant-vowel (VCV) nonsense words processed by low-pass and high-pass filters whose bandwidths were varied adaptively to produce specified performance levels in accordance with the transformed up-down rules of Levitt [(1971). J. Acoust. Soc. Am. 49, 467–477]. Local linear psychometric functions were fit to resulting data and used to generate an importance function for VCV words. Results indicate that the adaptive method is reliable and efficient, and produces importance function data consistent with that of the corresponding AI/SII importance function. PMID:22225057

  17. iGrid2002 Demonstration: Bandwidth from the Low Lands

    SciTech Connect

    Cottrell, Les

    2002-11-01

    We report on a demonstration of several complementary high performance end-to-end active network throughput measurement tools. These include: the PingWorld Java applet that displays the Round Trip Time (RTT) and losses to sites around the world from the user's host; the multi-path analysis tool that visualizes common paths from traceroutes to selected hosts; the IEPM high-performance BandWidth monitoring toolkit which gives achievable throughput for several types of TCP data transfer applications; and the Available Bandwidth Estimation (ABWE) tool that reports in real time the available bandwidth to several paths within the range from Mbits/s to Gbit/s. We also demonstrated sending high-speed data from 4 hosts at iGrid2002 to over 30 hosts in 10 countries to simulate a high energy physics experiment distributing data to collaborators. The demonstration utilized the high-speed, long latency, trans-Atlantic network set up for iGrid2002 in Amsterdam during September 2002.

  18. Ultra-high bandwidth quantum secured data transmission

    NASA Astrophysics Data System (ADS)

    Dynes, James F.; Tam, Winci W.-S.; Plews, Alan; Fröhlich, Bernd; Sharpe, Andrew W.; Lucamarini, Marco; Yuan, Zhiliang; Radig, Christian; Straw, Andrew; Edwards, Tim; Shields, Andrew J.

    2016-10-01

    Quantum key distribution (QKD) provides an attractive means for securing communications in optical fibre networks. However, deployment of the technology has been hampered by the frequent need for dedicated dark fibres to segregate the very weak quantum signals from conventional traffic. Up until now the coexistence of QKD with data has been limited to bandwidths that are orders of magnitude below those commonly employed in fibre optic communication networks. Using an optimised wavelength divisional multiplexing scheme, we transport QKD and the prevalent 100 Gb/s data format in the forward direction over the same fibre for the first time. We show a full quantum encryption system operating with a bandwidth of 200 Gb/s over a 100 km fibre. Exploring the ultimate limits of the technology by experimental measurements of the Raman noise, we demonstrate it is feasible to combine QKD with 10 Tb/s of data over a 50 km link. These results suggest it will be possible to integrate QKD and other quantum photonic technologies into high bandwidth data communication infrastructures, thereby allowing their widespread deployment.

  19. Method and apparatus for telemetry adaptive bandwidth compression

    NASA Astrophysics Data System (ADS)

    Graham, Olin L.

    1987-07-01

    Methods and apparatus are provided for automatic and/or manual adaptive bandwidth compression of telemetry. An adaptive sampler samples a video signal from a scanning sensor and generates a sequence of sampled fields. Each field and range rate information from the sensor are hence sequentially transmitted to and stored in a multiple and adaptive field storage means. The field storage means then, in response to an automatic or manual control signal, transfers the stored sampled field signals to a video monitor in a form for sequential or simultaneous display of a desired number of stored signal fields. The sampling ratio of the adaptive sample, the relative proportion of available communication bandwidth allocated respectively to transmitted data and video information, and the number of fields simultaneously displayed are manually or automatically selectively adjustable in functional relationship to each other and detected range rate. In one embodiment, when relatively little or no scene motion is detected, the control signal maximizes sampling ratio and causes simultaneous display of all stored fields, thus maximizing resolution and bandwidth available for data transmission. When increased scene motion is detected, the control signal is adjusted accordingly to cause display of fewer fields. If greater resolution is desired, the control signal is adjusted to increase the sampling ratio.

  20. The effect of hearing aid bandwidth on speech recognition performance of listeners using a cochlear implant and contralateral hearing aid (bimodal hearing)

    PubMed Central

    Neuman, Arlene C.; Svirsky, Mario A.

    2013-01-01

    Objectives The purpose of this study was to determine how the bandwidth of the hearing aid (HA) fitting affects bimodal speech recognition of listeners with a cochlear implant (CI) in one ear and severe-to-profound hearing loss in the unimplanted ear (but with residual hearing sufficient for wideband amplification using NAL-RP prescriptive guidelines; unaided thresholds no poorer than 95 dB HL through 2000 Hz). Design Recognition of sentence material in quiet and in noise was measured with the CI alone and with CI plus HA as the amplification provided by the hearing aid in the high and mid-frequency regions was systematically reduced from the wideband condition (NAL-RP prescription). Modified bandwidths included upper frequency cutoffs of 2,000, 1,000 or 500 Hz. Results On average, significant bimodal benefit was obtained when the hearing aid provided amplification at all frequencies with aidable residual hearing. Limiting the hearing aid bandwidth to only low frequency amplification (below 1000 Hz) did not yield significant improvements in performance over listening with the CI alone. Conclusion These data suggest the importance of providing amplification across as wide a frequency region as permitted by audiometric thresholds in the hearing aid used by bimodal users. PMID:23632973

  1. High-Density, High-Bandwidth, Multilevel Holographic Memory

    NASA Technical Reports Server (NTRS)

    Chao, Tien-Hsin

    2008-01-01

    A proposed holographic memory system would be capable of storing data at unprecedentedly high density, and its data transfer performance in both reading and writing would be characterized by exceptionally high bandwidth. The capabilities of the proposed system would greatly exceed even those of a state-of-the art memory system, based on binary holograms (in which each pixel value represents 0 or 1), that can hold .1 terabyte of data and can support a reading or writing rate as high as 1 Gb/s. The storage capacity of the state-of-theart system cannot be increased without also increasing the volume and mass of the system. However, in principle, the storage capacity could be increased greatly, without significantly increasing the volume and mass, if multilevel holograms were used instead of binary holograms. For example, a 3-bit (8-level) hologram could store 8 terabytes, or an 8-bit (256-level) hologram could store 256 terabytes, in a system having little or no more size and mass than does the state-of-the-art 1-terabyte binary holographic memory. The proposed system would utilize multilevel holograms. The system would include lasers, imaging lenses and other beam-forming optics, a block photorefractive crystal wherein the holograms would be formed, and two multilevel spatial light modulators in the form of commercially available deformable-mirror-device spatial light modulators (DMDSLMs) made for use in high speed input conversion of data up to 12 bits. For readout, the system would also include two arrays of complementary metal oxide/semiconductor (CMOS) photodetectors matching the spatial light modulators. The system would further include a reference-beam sterring device (equivalent of a scanning mirror), containing no sliding parts, that could be either a liquid-crystal phased-array device or a microscopic mirror actuated by a high-speed microelectromechanical system. Time-multiplexing and the multilevel nature of the DMDSLM would be exploited to enable writing

  2. Astragaloside IV ameliorates renal injury in db/db mice

    PubMed Central

    Sun, Huili; Wang, Wenjing; Han, Pengxun; Shao, Mumin; Song, Gaofeng; Du, Heng; Yi, Tiegang; Li, Shunmin

    2016-01-01

    Diabetic nephropathy is a lethal complication of diabetes mellitus and a major type of chronic kidney disease. Dysregulation of the Akt pathway and its downstream cascades, including mTOR, NFκB, and Erk1/2, play a critical role in the development of diabetic nephropathy. Astragaloside IV is a major component of Huangqi and exerts renal protection in a mouse model of type 1 diabetes. The current study was undertaken to investigate the protective effects of diet supplementation of AS-IV on renal injury in db/db mice, a type 2 diabetic mouse model. Results showed that administration of AS-IV reduced albuminuria, ameliorated changes in the glomerular and tubular pathology, and decreased urinary NAG, NGAL, and TGF-β1 in db/db mice. AS-IV also attenuated the diabetes-related activation of Akt/mTOR, NFκB, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. Collectively, these findings showed AS-IV to be beneficial to type 2 diabetic nephropathy, which might be associated with the inhibition of Akt/mTOR, NFκB and Erk1/2 signaling pathways. PMID:27585918

  3. Astragaloside IV ameliorates renal injury in db/db mice

    NASA Astrophysics Data System (ADS)

    Sun, Huili; Wang, Wenjing; Han, Pengxun; Shao, Mumin; Song, Gaofeng; Du, Heng; Yi, Tiegang; Li, Shunmin

    2016-09-01

    Diabetic nephropathy is a lethal complication of diabetes mellitus and a major type of chronic kidney disease. Dysregulation of the Akt pathway and its downstream cascades, including mTOR, NFκB, and Erk1/2, play a critical role in the development of diabetic nephropathy. Astragaloside IV is a major component of Huangqi and exerts renal protection in a mouse model of type 1 diabetes. The current study was undertaken to investigate the protective effects of diet supplementation of AS-IV on renal injury in db/db mice, a type 2 diabetic mouse model. Results showed that administration of AS-IV reduced albuminuria, ameliorated changes in the glomerular and tubular pathology, and decreased urinary NAG, NGAL, and TGF-β1 in db/db mice. AS-IV also attenuated the diabetes-related activation of Akt/mTOR, NFκB, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. Collectively, these findings showed AS-IV to be beneficial to type 2 diabetic nephropathy, which might be associated with the inhibition of Akt/mTOR, NFκB and Erk1/2 signaling pathways.

  4. Astragaloside IV ameliorates renal injury in db/db mice.

    PubMed

    Sun, Huili; Wang, Wenjing; Han, Pengxun; Shao, Mumin; Song, Gaofeng; Du, Heng; Yi, Tiegang; Li, Shunmin

    2016-01-01

    Diabetic nephropathy is a lethal complication of diabetes mellitus and a major type of chronic kidney disease. Dysregulation of the Akt pathway and its downstream cascades, including mTOR, NFκB, and Erk1/2, play a critical role in the development of diabetic nephropathy. Astragaloside IV is a major component of Huangqi and exerts renal protection in a mouse model of type 1 diabetes. The current study was undertaken to investigate the protective effects of diet supplementation of AS-IV on renal injury in db/db mice, a type 2 diabetic mouse model. Results showed that administration of AS-IV reduced albuminuria, ameliorated changes in the glomerular and tubular pathology, and decreased urinary NAG, NGAL, and TGF-β1 in db/db mice. AS-IV also attenuated the diabetes-related activation of Akt/mTOR, NFκB, and Erk1/2 signaling pathways without causing any detectable hepatotoxicity. Collectively, these findings showed AS-IV to be beneficial to type 2 diabetic nephropathy, which might be associated with the inhibition of Akt/mTOR, NFκB and Erk1/2 signaling pathways. PMID:27585918

  5. Highly Scaled InP/InGaAs DHBTs Beyond 1 THz Bandwidth

    NASA Astrophysics Data System (ADS)

    Rode, Johann Christian

    This work examines the efforts pursued to extend the bandwidth of InP-based DHBTs above 1 THz. Aggressive lithographic and epitaxial scaling of key device dimensions and simultaneous reduction of contact resistivities have enabled increased RF bandwidths by reduction of device RC and transit delays. A fabrication process for forming base electrodes and base/collector mesas of highly scaled transistors has been developed that exploits superior resolution (10nm) and alignment (<30nm) of electron beam lithography. Ultra-low resistance, thermally stable base contacts are critical for extended fmax bandwidth: a novel dual-deposition base metalization technique is presented that removes contaminating lithographic processes from the formation of the base contact, thereby enabling low resistivity contacts (4 Ω-microm2) to ultra-thin base layers (20 nm). The composite base metal stack exploits an ultra-thin layer of platinum that controllably reacts with base, yielding low contact resistivity, as well as a thick refractory diffusion barrier which permits stable operation at high current densities and elevated temperatures. Reduction in emitter-base surface leakage and subsequent increase of current gain was achieved by passivating emitter-base semiconductor surfaces with conformally grown ALD Al2O3. RF bandwidth limiting parasitics associated to the perimeter of highly scaled transistors have been identified and significantly reduced, among which are high sheet resistance of base electrodes, excess undercut of emitter stripes and improperly scaled base posts. At 100nm collector thickness, the breakdown voltage of the transistor BVCEO has been increased to more than 4.1V by passivating base/collector surfaces. With the technology improvements discussed, transistors with ftau of 480 GHz and fmax in excess of 1 THz have been demonstrated at 200nm emitter width and 80nm single-sided base contact width. Transistors at the same emitter width, but 30nm base contact width exhibit

  6. 3D Hot Test Simulations of a 220 GHz Folded Waveguide Traveling Wave Tube Using a CFDTD PIC Method

    NASA Astrophysics Data System (ADS)

    Lin, Ming-Chieh; Song, Heather

    2015-11-01

    Millimeter or sub-THz wave sources centered at 220 GHz is of interest due to the potential for its commercial and military applications including high resolution radar, remote sensing, and high-data-rate communications. It has been demonstrated via 3D cold test finite element method (FEM) simulations that a folded waveguide traveling wave tube (FWTWT) can be designed and optimized at this frequency range with a small signal gain of 18 dB over a comparatively broad (-3 dB) bandwidth of ~ 10%. On the other hand, 3D hot test simulations of a V-band ladder TWT have been successfully demonstrated using a conformal finite-difference time-domain (CFDTD) particle-in-cell (PIC) method for center frequency of 50 GHz. In the present work, the 220 GHz FWTWT designs have been reviewed and studied. 3D Cold test simulations using both the CFDTD and FEM methods have been carried out and compared with each other as basis for 3D hot test CFDTD PIC simulations. The preliminary simulation result shows that the gain-bandwidth features at 220 GHz are achievable while carefully avoiding beam interceptions. Our study shows that the interaction characteristics are very sensitive to the operating beam parameters. Detail simulation results and discussions will be presented.

  7. Plasma zinc status and membrane lipid composition in genetically diabetic mice (db/db)

    SciTech Connect

    Burke, J.P.; Fenton, M.R.

    1986-03-05

    Sex and age matched diabetic C57BL/Ks-db+/db+ mice (db/db) were sacrificed at eight weeks of age. Plasma samples were collected and zinc levels determined. Livers were excised and mitochondrial and microsomal membranes prepared. Aliquots of membrane fractions were subjected to lipid extraction and cholesterol (Cl), phospholipid (PL) and fatty acid analysis (FA) performed. Plasma zinc levels in db/db mice were elevated 25% compared to m/m controls (148.8+/-8.1 ..mu..g/dl vs. 118.9+/-14.9 ..mu..g/dl). Cholesterol and PL levels remained unchanged in both mitochondrial and microsomal membranes. Analysis of PL composition from db/db mitochondria by two dimensional thin layer chromatography revealed no change in the percentage of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) but a 40% decrease in cardiolipin. Slight increases were observed in the percentage of phosphatidylserine and phosphatidylinositol (PS+PI) in microsomes isolated from db/db mice. Fatty acid analysis of microsomal PC and PE showed a decrease of 28% in the 18:1/18:0 ratio as well as a 21% decrease in the ratio of 20:4/18:2 in db/db animals. Analysis of succinate dehydrogenase (mitochondrial) and glucose-6-phosphatase (microsomal) revealed significant decreases in activity in livers of db/db mice. The altered zinc metabolism as well as the changes in membrane lipid composition suggest that this may be a model to study the role of zinc in membrane structure.

  8. Oral green tea catechins transiently lower plasma glucose concentrations in female db/db mice.

    PubMed

    Wein, Silvia; Schrader, Eva; Rimbach, Gerald; Wolffram, Siegfried

    2013-04-01

    Polyphenols, including green tea catechins, are secondary plant compounds often discussed in the context of health-promoting potential. Evidence for such effects is mainly derived from epidemiological and cell culture studies. The aim of the present study was to investigate antidiabetic, antiadipogenic, and anti-inflammatory effects at nonpharmacological doses in an obese diabetic mouse model that exerts early relevant clinical signs of non-insulin-dependent diabetes mellitus. Female db/db mice received a flavonoid-poor diet either without additive, with rosiglitazone (RSG, 0.02 g/kg diet), or with green tea extract (low-dose green tea extract [LGTE] and high-dose green tea extract [HGTE], 0.1 and 1 g/kg diet). Food and water were freely available. The body weight was monitored weekly. Blood was sampled (12-h fasted) from the tail vein on day 28 and analyzed for glucose, cholesterol, triacylglycerol, nonesterified fatty acids, insulin, adiponectin, and soluble intercellular adhesion molecule-1 (sICAM-1). Blood glucose was also analyzed on day 14. Furthermore, sICAM-1 release was investigated in tumor necrosis factor alpha-stimulated EAhy926 cells. After 14 days, fasting glycemia was improved by RSG or HGTE supplementation compared to controls. However, at the end of the study (day 28), only RSG exhibited glucose-lowering effects and induced plasma adiponectin concentrations, paralleled by higher body weight gain and reduced periuterine fat pads compared to controls. However, only GTE treatment reduced sICAM-1 release in vitro and in vivo. Nonpharmacological HGTE supplementation in db/db mice caused (1) no adiponectin-inducing or antiadipogenic effects, (2) reduced sICAM-1 release, thereby potentially exerting anti-inflammatory effects in the progressive diabetic state, and (3) a transient improvement in glycemia.

  9. Oral green tea catechins transiently lower plasma glucose concentrations in female db/db mice.

    PubMed

    Wein, Silvia; Schrader, Eva; Rimbach, Gerald; Wolffram, Siegfried

    2013-04-01

    Polyphenols, including green tea catechins, are secondary plant compounds often discussed in the context of health-promoting potential. Evidence for such effects is mainly derived from epidemiological and cell culture studies. The aim of the present study was to investigate antidiabetic, antiadipogenic, and anti-inflammatory effects at nonpharmacological doses in an obese diabetic mouse model that exerts early relevant clinical signs of non-insulin-dependent diabetes mellitus. Female db/db mice received a flavonoid-poor diet either without additive, with rosiglitazone (RSG, 0.02 g/kg diet), or with green tea extract (low-dose green tea extract [LGTE] and high-dose green tea extract [HGTE], 0.1 and 1 g/kg diet). Food and water were freely available. The body weight was monitored weekly. Blood was sampled (12-h fasted) from the tail vein on day 28 and analyzed for glucose, cholesterol, triacylglycerol, nonesterified fatty acids, insulin, adiponectin, and soluble intercellular adhesion molecule-1 (sICAM-1). Blood glucose was also analyzed on day 14. Furthermore, sICAM-1 release was investigated in tumor necrosis factor alpha-stimulated EAhy926 cells. After 14 days, fasting glycemia was improved by RSG or HGTE supplementation compared to controls. However, at the end of the study (day 28), only RSG exhibited glucose-lowering effects and induced plasma adiponectin concentrations, paralleled by higher body weight gain and reduced periuterine fat pads compared to controls. However, only GTE treatment reduced sICAM-1 release in vitro and in vivo. Nonpharmacological HGTE supplementation in db/db mice caused (1) no adiponectin-inducing or antiadipogenic effects, (2) reduced sICAM-1 release, thereby potentially exerting anti-inflammatory effects in the progressive diabetic state, and (3) a transient improvement in glycemia. PMID:23514230

  10. Broad-bandwidth Metamaterial Antireflection Coatings for Sub-Millimeter Astronomy and CMB Foreground Removal

    NASA Astrophysics Data System (ADS)

    McMahon, Jeff

    Sub-millimeter observations are crucial for answering questions about star and galaxy formation; understanding galactic dust foregrounds; and for removing these foregrounds to detect the faint signature of inflationary gravitational waves in the polarization of the Cosmic Microwave Background (CMB). Achieving these goals requires improved, broad-band antireflection coated lenses and half-wave plates (HWPs). These optical elements will significantly boost the sensitivity and capability of future sub-millimeter and CMB missions. We propose to develop wide-bandwidth metamaterial antireflection coatings for silicon lenses and sapphire HWPs with 3:1 ratio bandwidth that are scalable across the sub-millimeter band from 300 GHz to 3 THz. This is an extension of our successful work on saw cut metamaterial AR coatings for silicon optics at millimeter wave lengths. These, and the proposed coatings consist of arrays of sub-wavelength scale features cut into optical surfaces that behave like simple dielectrics. We have demonstrated saw cut 3:1 bandwidth coatings on silicon lenses, but these coatings are limited to the millimeter wave band by the limitations of dicing saw machining. The crucial advance needed to extend these broad band coatings throughout the sub-millimeter band is the development of laser cut graded index metamaterial coatings. The proposed work includes developing the capability to fabricate these coatings, optimizing the design of these metamaterials, fabricating and testing prototype lenses and HWPs, and working with the PIPER collaboration to achieve a sub-orbital demonstration of this technology. The proposed work will develop potentially revolutionary new high performance coatings for the sub-millimeter bands, and cary this technology to TRL 7 paving the way for its use in space. We anticipate that there will be a wide range of applications for these coatings on future NASA balloons and satellites.

  11. Improving the modulation bandwidth of LED by CdSe/ZnS quantum dots for visible light communication.

    PubMed

    Xiao, Xiangtian; Tang, Haodong; Zhang, Tianqi; Chen, Wei; Chen, Wanli; Wu, Dan; Wang, Rui; Wang, Kai

    2016-09-19

    Visible light communication (VLC) is an advanced and high-efficiency wireless communication technology. As one of the most important light sources in VLC, conventional white light emitting diode (WLED) based on Y3Al5O12:Ce3+ (YAG:Ce) phosphor limits the system transmitting rate severely due to its narrow modulation bandwidth. Considering the short fluorescent lifetime of quantum dots (QDs), QD-LEDs with wide modulation bandwidths were designed here to improve the transmitting rate of VLC. CdSe/ZnS core/shell QDs and related luminescent microspheres (LMS) were implemented as light conversion materials for the QD-LEDs. Compared with conventional phosphor WLED, the proposed QD-LED and QD-WLED reached maximum improvement on modulation bandwidth at 74.19% and 67.75% respectively. Furthermore, mathematical modeling of smearing was analyzed to establish the relationship between fluorescent lifetime and modulation bandwidth. Our findings will provide an effective solution of white LEDs for high speed VLC. PMID:27661896

  12. Improving the modulation bandwidth of LED by CdSe/ZnS quantum dots for visible light communication.

    PubMed

    Xiao, Xiangtian; Tang, Haodong; Zhang, Tianqi; Chen, Wei; Chen, Wanli; Wu, Dan; Wang, Rui; Wang, Kai

    2016-09-19

    Visible light communication (VLC) is an advanced and high-efficiency wireless communication technology. As one of the most important light sources in VLC, conventional white light emitting diode (WLED) based on Y3Al5O12:Ce3+ (YAG:Ce) phosphor limits the system transmitting rate severely due to its narrow modulation bandwidth. Considering the short fluorescent lifetime of quantum dots (QDs), QD-LEDs with wide modulation bandwidths were designed here to improve the transmitting rate of VLC. CdSe/ZnS core/shell QDs and related luminescent microspheres (LMS) were implemented as light conversion materials for the QD-LEDs. Compared with conventional phosphor WLED, the proposed QD-LED and QD-WLED reached maximum improvement on modulation bandwidth at 74.19% and 67.75% respectively. Furthermore, mathematical modeling of smearing was analyzed to establish the relationship between fluorescent lifetime and modulation bandwidth. Our findings will provide an effective solution of white LEDs for high speed VLC.

  13. Simple microscope using a compound refractive lens and a wide-bandwidth thermal neutron beam

    SciTech Connect

    Cremer, J. T.; Park, H.; Piestrup, M. A.; Gary, C. K.; Pantell, R. H.; Flocchini, R. G.; Egbert, H. P.; Kloh, M. D.; Walker, R. B.

    2007-04-02

    The results of imaging experiments using biconcave, spherical compound refractive lenses (CRLs) and a wide-bandwidth thermal neutron beam are presented. Two CRLs were used, consisting of 155 beryllium and 120 copper lenses. The experiments were performed using a thermal neutron beam line at McClellan Nuclear Radiation Center reactor. The authors obtained micrographs of cadmium slits with up to 5x magnification and 0.3 mm resolution. The CRL resolution was superior to a pinhole camera with the same aperture diameter. The modulation transfer function (MTF) of the CRL was calculated and compared with the measured MTF at five spatial frequencies, showing good agreement.

  14. A High-Frequency Annular-Array Transducer Using an Interdigital Bonded 1-3 Composite

    PubMed Central

    Chabok, Hamid Reza; Cannata, Jonathan M.; Kim, Hyung Ham; Williams, Jay A.; Park, Jinhyoung; Shung, K. Kirk

    2011-01-01

    This paper reports the design, fabrication, and characterization of a 1–3 composite annular-array transducer. An interdigital bonded (IB) 1–3 composite was prepared using two IB operations on a fine-grain piezoelectric ceramic. The final composite had 19-μm-wide posts separated by 6-μm-wide polymer kerfs. A novel method to remove metal electrodes from polymer portions of the 1–3 composite was established to eliminate the need for patterning and aligning the electrode on the composite to the electrodes on a flexible circuit. Unloaded epoxy was used for both the matching and backing layers and a flexible circuit was used for interconnect. A prototype array was successfully fabricated and tested. The results were in reasonable agreement with those predicted by a circuit-analogous model. The average center frequency estimated from the measured pulse-echo responses of array elements was 33.5 MHz and the −6-dB fractional bandwidth was 57%. The average insertion loss recorded was 14.3 dB, and the maximum crosstalk between the nearest-neighbor elements was less than −37 dB. Images of a wire phantom and excised porcine eye were obtained to show the capabilities of the array for high-frequency ultrasound imaging. PMID:21244988

  15. Low Bandwidth Vocoding using EM Sensor and Acoustic Signal Processing

    SciTech Connect

    Ng, L C; Holzrichter, J F; Larson, P E

    2001-10-25

    Low-power EM radar-like sensors have made it possible to measure properties of the human speech production system in real-time, without acoustic interference [1]. By combining these data with the corresponding acoustic signal, we've demonstrated an almost 10-fold bandwidth reduction in speech compression, compared to a standard 2.4 kbps LPC10 protocol used in the STU-III (Secure Terminal Unit, third generation) telephone. This paper describes a potential EM sensor/acoustic based vocoder implementation.

  16. Measurement of formant frequencies and bandwidths in singing.

    PubMed

    Schutte, H K; Miller, D G; Svec, J G

    1995-09-01

    That singers under certain circumstances adjust the articulation of the vocal tract (formant tuning) to enhance acoustic output is both apparent from measurements and understood in theory. The precise effect of a formant on an approaching (retreating) harmonic as the latter varies in frequency during actual singing, however, is difficult to isolate. In this study variations in amplitude of radiated sound components as well as supraglottal and subglottal (esophageal) pressures accompanying the vibrato-related sweep of voice harmonics were used as a basis for estimating the effective center frequencies and bandwidths of the first and second formants. PMID:8541972

  17. Flexible All-Digital Receiver for Bandwidth Efficient Modulations

    NASA Technical Reports Server (NTRS)

    Gray, Andrew; Srinivasan, Meera; Simon, Marvin; Yan, Tsun-Yee

    2000-01-01

    An all-digital high data rate parallel receiver architecture developed jointly by Goddard Space Flight Center and the Jet Propulsion Laboratory is presented. This receiver utilizes only a small number of high speed components along with a majority of lower speed components operating in a parallel frequency domain structure implementable in CMOS, and can currently process up to 600 Mbps with standard QPSK modulation. Performance results for this receiver for bandwidth efficient QPSK modulation schemes such as square-root raised cosine pulse shaped QPSK and Feher's patented QPSK are presented, demonstrating the flexibility of the receiver architecture.

  18. Optimizing bandwidth utilization in packet based telemetry systems

    SciTech Connect

    Kalibjian, J.R.

    1995-10-17

    A consistent theme in spacecraft telemetry system design is the desire to obtain maximum bandwidth utilization given a fixed transmission capability (usually due to cost/weight criteria). Extensions to basic packetization telemetry architectures are discussed which can facilitate a reduction in the amount of actual data telemetered, without loss of data quality. Central to the extensions are the establishment of an ``intelligent`` telemetry process, which can evaluate pending data to be telemetered, and act to compress, discard, or re-formulate data before actual transmission to ground stations.

  19. Systems for measuring response statistics of gigahertz bandwidth photomultipliers

    NASA Technical Reports Server (NTRS)

    Abshire, J. B.; Rowe, H. E.

    1977-01-01

    New systems have been developed for measuring the average impulse response, the pulse-height spectrum, the transit-time statistics as a function of signal level, and the dark-count spectrum of gigahertz bandwidth photomultipliers. Measurements showed that the 0.53 microns pulse used as an optical test source had a 30 picoseconds and less than 70 ps pulse width. Calibration data showed the system resolution to be less than 20 ps for root mean square transit-time measurements. Test data for a static crossed-field photomultiplier showed 2-photoelectron resolution and less than 30-ps time jitter over the 1- to 100-photoelectron range.

  20. The human as a detector of changes in variance and bandwidth

    NASA Technical Reports Server (NTRS)

    Curry, R. E.; Govindaraj, T.

    1977-01-01

    The detection of changes in random process variance and bandwidth was studied. Psychophysical thresholds for these two parameters were determined using an adaptive staircase technique for second order random processes at two nominal periods (1 and 3 seconds) and damping ratios (0.2 and 0.707). Thresholds for bandwidth changes were approximately 9% of nominal except for the (3sec,0.2) process which yielded thresholds of 12%. Variance thresholds averaged 17% of nominal except for the (3sec,0.2) process in which they were 32%. Detection times for suprathreshold changes in the parameters may be roughly described by the changes in RMS velocity of the process. A more complex model is presented which consists of a Kalman filter designed for the nominal process using velocity as the input, and a modified Wald sequential test for changes in the variance of the residual. The model predictions agree moderately well with the experimental data. Models using heuristics, e.g. level crossing counters, were also examined and are found to be descriptive but do not afford the unification of the Kalman filter/sequential test model used for changes in mean.

  1. Improving microwave antenna gain and bandwidth with phase compensation metasurface

    SciTech Connect

    Chen, Ke; Yang, Zhongjie; Feng, Yijun Zhu, Bo; Zhao, Junming; Jiang, Tian

    2015-06-15

    Metasurface, as a planar version of artificial metamaterial, provide an effective way to manipulate electromagnetic wave propagation. Here, we present a transparent metasurface for compensating the out-of-phase radiation from a microstrip patch antenna to improve its radiation gain and bandwidth. Based on the equivalence principle of Huygens’ surface, we propose metasurface composed of both inductive and capacitive resonant elements which could produce high transmission with variable phase characteristics. Such metasurface mounted on a patch antenna can transform the spherical-like phase profile generated from the patch into an in-phase planar one. A prototype antenna has been fabricated and validated the squeezed radiation pattern with suppressed sidelobes as well as enhanced impedance bandwidth due to strong near-field coupling. As operating at around 5.7 GHz, the proposed antenna may have potential application in wireless communication systems especially for point-to-point data transmission. It is believed that the design methodology could also be scaled to other frequency bands such as millimeter or terahertz wave.

  2. Modulation bandwidth of spin torque oscillators under current modulation

    SciTech Connect

    Quinsat, M.; Garcia-Sanchez, F.; Jenkins, A. S.; Buda-Prejbeanu, L. D.; Dieny, B.; Ebels, U.; Tiberkevich, V. S.; Slavin, A. N.; Zeltser, A.; Katine, J. A.; Cyrille, M.-C.

    2014-10-13

    For practical applications of spin torque nano-oscillators (STNO), one of the most critical characteristics is the speed at which an STNO responds to variations of external control parameters, such as current or/and field. Theory predicts that this speed is limited by the amplitude relaxation rate Γ{sub p} that determines the timescale over which the amplitude fluctuations are damped out. In this study, this limit is verified experimentally by analyzing the amplitude and frequency noise spectra of the output voltage signal when modulating an STNO by a microwave current. In particular, it is shown that due to the non-isochronous nature of the STNO the amplitude relaxation rate Γ{sub p} determines not only the bandwidth of an amplitude modulation, but also the bandwidth of a frequency modulation. The presented experimental technique will be important for the optimisation of the STNO characteristics for applications in telecommunications or/and data storage and is applicable even in the case when the STNO output signal is only several times higher than noise.

  3. A wide bandwidth electrostatic field sensor for lightning research

    NASA Technical Reports Server (NTRS)

    Zaepfel, Klaus P.

    1989-01-01

    Data obtained from UHF radar observation of direct-lightning strikes to the NASA F-106B aircraft have indicated that most of the 690 strikes acquired during direct-strike lightning tests were triggered by the aircraft. As an aid in understanding the triggered lightning process, a wide bandwidth electric field measuring system was designed for the F-106B by implementing a clamped-detection signal processing concept originated at the Air Force Cambridge Research Lab in 1953. The detection scheme combines the signals from complementary stator pairs clamped to zero bolts at the exact moment when each stator pair is maximally shielded by the rotor, a process that restores the dc level lost by the charge amplifier. The system was implemented with four shutter-type field mills located at strategic points on the aircraft. The bandwidth of the system was determined in the laboratory to be from dc to over 100 Hz, whereas past designs had upper limits of 10 to 100 Hz. To obtain the undisturbed electric field vector and total aircraft charge, the airborne field mill system is calibrated by using techniques involving results from ground and flight calibrations of the F-106B, laboratory tests of a metallized model, and a finite difference time-domain electromagnetic computer code.

  4. Flexible power and bandwidth allocation in mobile satellites

    NASA Astrophysics Data System (ADS)

    Keyes, L. A.

    The introduction of L-band mobile communication services by spot beam satellites creates a payload design challenge due to uncertainty in the location and size of the new market to be served. A combination of payload technologies that allow a flexible allocation of power and bandwidth to any portion of the coverage area is described. Power flexibility is achieved by a novel combination of a low-level beam-forming network and a matrix power module which ensures equal sharing of power among individual amplifiers. This eliminates the loss of efficiency and increased mass when an amplifier associated with a beam must be over-designed to meet uncertainties in power distribution between beams. Flexibility in allocation of bandwidth to beams is achieved by intermediate frequency subdivision of the L-band service categories defined by ITU. These spectral subdivisions are assigned to beams by an IF interconnect matrix having beam ports and filter ports as inputs and outputs, respectively. Two such filter switch matrices are required, one for the inbound L-band to feeder link transponder, and one for the outbound feeder link to L-band transponder.

  5. Multi-Modulator for Bandwidth-Efficient Communication

    NASA Technical Reports Server (NTRS)

    Gray, Andrew; Lee, Dennis; Lay, Norman; Cheetham, Craig; Fong, Wai; Yeh, Pen-Shu; King, Robin; Ghuman, Parminder; Hoy, Scott; Fisher, Dave

    2009-01-01

    A modulator circuit board has recently been developed to be used in conjunction with a vector modulator to generate any of a large number of modulations for bandwidth-efficient radio transmission of digital data signals at rates than can exceed 100 Mb/s. The modulations include quadrature phaseshift keying (QPSK), offset quadrature phase-shift keying (OQPSK), Gaussian minimum-shift keying (GMSK), and octonary phase-shift keying (8PSK) with square-root raised-cosine pulse shaping. The figure is a greatly simplified block diagram showing the relationship between the modulator board and the rest of the transmitter. The role of the modulator board is to encode the incoming data stream and to shape the resulting pulses, which are fed as inputs to the vector modulator. The combination of encoding and pulse shaping in a given application is chosen to maximize the bandwidth efficiency. The modulator board includes gallium arsenide serial-to-parallel converters at its input end. A complementary metal oxide/semiconductor (CMOS) field-programmable gate array (FPGA) performs the coding and modulation computations and utilizes parallel processing in doing so. The results of the parallel computation are combined and converted to pulse waveforms by use of gallium arsenide parallel-to-serial converters integrated with digital-to-analog converters. Without changing the hardware, one can configure the modulator to produce any of the designed combinations of coding and modulation by loading the appropriate bit configuration file into the FPGA.

  6. Unmanned Aircraft System Control and ATC Communications Bandwidth Requirements

    NASA Technical Reports Server (NTRS)

    Henriksen, Steve

    2008-01-01

    There are significant activities taking place to establish the procedures and requirements for safe and routine operation of unmanned aircraft systems (UAS) in the National Airspace System (NAS). Among the barriers to overcome in achieving this goal is the lack of sufficient frequency spectrum necessary for the UAS control and air traffic control (ATC) communications links. This shortcoming is compounded by the fact that the UAS control communications links will likely be required to operate in protected frequency spectrum, just as ATC communications links are, because they relate to "safety and regularity of flight." To support future International Telecommunications Union (ITU) World Radio Conference (WRC) agenda items concerning new frequency allocations for UAS communications links, and to augment the Future Communications Study (FCS) Technology Evaluation Group efforts, NASA Glenn Research Center has sponsored a task to estimate the UAS control and ATC communications bandwidth requirements for safe, reliable, and routine operation of UAS in the NAS. This report describes the process and results of that task. The study focused on long-term bandwidth requirements for UAS approximately through 2030.

  7. Ionospheric Coherence Bandwidth Measurements in the Lower VHF Frequency Range

    NASA Astrophysics Data System (ADS)

    Suszcynsky, D. M.; Light, M. E.; Pigue, M. J.

    2015-12-01

    The United States Department of Energy's Radio Frequency Propagation (RFProp) experiment consists of a satellite-based radio receiver suite to study various aspects of trans-ionospheric signal propagation and detection in four frequency bands, 2 - 55 MHz, 125 - 175 MHz, 365 - 415 MHz and 820 - 1100 MHz. In this paper, we present simultaneous ionospheric coherence bandwidth and S4 scintillation index measurements in the 32 - 44 MHz frequency range collected during the ESCINT equatorial scintillation experiment. 40-MHz continuous wave (CW) and 32 - 44 MHz swept frequency signals were transmitted simultaneously to the RFProp receiver suite from the Reagan Test Site at Kwajalein Atoll in the Marshall Islands (8.7° N, 167.7° E) in three separate campaigns during the 2014 and 2015 equinoxes. Results show coherence bandwidths as small as ~ 1 kHz for strong scintillation (S4 > 0.7) and indicate a high degree of ionospheric variability and irregularity on 10-m spatial scales. Spread-Doppler clutter effects arising from preferential ray paths to the satellite due to refraction off of isolated density irregularities are also observed and are dominant at low elevation angles. The results are compared to previous measurements and available scaling laws.

  8. Specification for wide channel bandwidth one-inch video tape

    NASA Technical Reports Server (NTRS)

    Perry, Jimmy L.

    1988-01-01

    Standards and controls are established for the procurement of wide channel bandwidth one inch video magnetic recording tapes for Very Long Base Interferometer (VLBI) system applications. The Magnetic Tape Certification Facility (MTCF) currently maintains three specifications for the Quality Products List (QPL) and acceptance testing of magnetic tapes. NASA-TM-79724 is used for the QPL and acceptance testing of new analog tapes; NASA-TM-80599 is used for QPL and acceptance testing of new digital tapes; and NASA-TM-100702 is used for the QPL and acceptance testing of new IBM/IBM compatible 3480 magnetic tape cartridges. This specification will be used for the QPL and acceptance testing of new wide channel bandwidth one inch video magnetic recording tapes. The one inch video tapes used by the Jet Propulsion Lab., the Deep Space Network and the Haystack Observatory will be covered by this specification. These NASA stations will use the video tapes for their VLBI system applications. The VLBI system is used for the tracking of quasars and the support of interplanetary exploration.

  9. X-ray FEL with a meV bandwidth

    NASA Astrophysics Data System (ADS)

    Saldin, E. L.; Schneidmiller, E. A.; Shvyd'ko, Yu. V.; Yurkov, M. V.

    2001-12-01

    A new design for a single pass X-ray Self-Amplified Spontaneous Emission (SASE) FEL was proposed by Feldhaus et al. (Opt. Commun. 140 (1997) 341) and named "two-stage SASE FEL". The scheme consists of two undulators and an X-ray monochromator located between them. For the Angström wavelength range the monochromator can be realized using Bragg reflections from crystals. We propose a scheme of monochromator with a bandwidth of 20 meV for the 14.4 keV X-ray SASE FEL being developed in the framework of the TESLA linear collider project. The spectral bandwidth of the radiation from the two-stage SASE FEL (20 meV) is determined by the finite duration of the electron pulse. The shot-to-shot fluctuations of energy spectral density are dramatically reduced in comparison with the 100% fluctuations in a SASE FEL. The peak and average brilliance are three orders of magnitude higher than the values which could be reached by a conventional X-ray SASE FEL.

  10. Programmable noise bandwidth reduction by means of digital averaging

    NASA Technical Reports Server (NTRS)

    Poklemba, John J. (Inventor)

    1993-01-01

    Predetection noise bandwidth reduction is effected by a pre-averager capable of digitally averaging the samples of an input data signal over two or more symbols, the averaging interval being defined by the input sampling rate divided by the output sampling rate. As the averaged sample is clocked to a suitable detector at a much slower rate than the input signal sampling rate the noise bandwidth at the input to the detector is reduced, the input to the detector having an improved signal to noise ratio as a result of the averaging process, and the rate at which such subsequent processing must operate is correspondingly reduced. The pre-averager forms a data filter having an output sampling rate of one sample per symbol of received data. More specifically, selected ones of a plurality of samples accumulated over two or more symbol intervals are output in response to clock signals at a rate of one sample per symbol interval. The pre-averager includes circuitry for weighting digitized signal samples using stored finite impulse response (FIR) filter coefficients. A method according to the present invention is also disclosed.

  11. Progressive raster imagery beyond a means to overcome limited bandwidth

    NASA Astrophysics Data System (ADS)

    Rosenbaum, René; Schumann, Heidrun

    2009-02-01

    Progressive refinement is a well-established approach to overcome bandwidth limitations in mobile environments. One outstanding benefit compared to relates approaches is the provision of meaningful content previews during data transfer or processing. Although highly relevant and useful, however, related literature only addresses the support of this functionality by certain communication stages or proposes systems for specific use cases. No publication is concerned with an abstraction or formalization of progression or takes advantage of its beneficial properties in other application fields. In this publication we want to give a general view to progression, its key concepts, attributes, and common data processing pipeline. Thereby, we abstract from specifics and usage scenarios in order to simplify the development of new algorithms and schemes and to derive guidelines for its general application. To show that progression is also able to solve problems beyond limited bandwidth, this contribution is also concerned with the introduction of new application areas. The novel idea of content-oriented refinement allows emphasizing important image regions by an animated tour-through-the-data. It will also be shown that progressive representations are a very effective means for device adaptation. Both applications are motivated, discussed, and illustrated by different examples.

  12. Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse, a type 2 diabetes model.

    PubMed

    Shi, Tie-Jun Sten; Zhang, Ming-Dong; Zeberg, Hugo; Nilsson, Johanna; Grünler, Jacob; Liu, Su-Xing; Xiang, Qiong; Persson, Jonas; Fried, Kaj J; Catrina, Sergiu Bogdan; Watanabe, Masahiko; Arhem, Peter; Brismar, Kerstin; Hökfelt, Tomas G M

    2013-01-01

    Diabetic peripheral neuropathy (DPN) is the most common complication in both type 1 and type 2 diabetes. Here we studied some phenotypic features of a well-established animal model of type 2 diabetes, the leptin receptor-deficient db(-)/db(-) mouse, and also the effect of long-term (6 mo) treatment with coenzyme Q10 (CoQ10), an endogenous antioxidant. Diabetic mice at 8 mo of age exhibited loss of sensation, hypoalgesia (an increase in mechanical threshold), and decreases in mechanical hyperalgesia, cold allodynia, and sciatic nerve conduction velocity. All these changes were virtually completely absent after the 6-mo, daily CoQ10 treatment in db(-)/db(-) mice when started at 7 wk of age. There was a 33% neuronal loss in the lumbar 5 dorsal root ganglia (DRGs) of the db(-)/db(-) mouse versus controls at 8 mo of age, which was significantly attenuated by CoQ10. There was no difference in neuron number in 5/6-wk-old mice between diabetic and control mice. We observed a strong down-regulation of phospholipase C (PLC) β3 in the DRGs of diabetic mice at 8 mo of age, a key molecule in pain signaling, and this effect was also blocked by the 6-mo CoQ10 treatment. Many of the phenotypic, neurochemical regulations encountered in lumbar DRGs in standard models of peripheral nerve injury were not observed in diabetic mice at 8 mo of age. These results suggest that reactive oxygen species and reduced PLCβ3 expression may contribute to the sensory deficits in the late-stage diabetic db(-)/db(-) mouse, and that early long-term administration of the antioxidant CoQ10 may represent a promising therapeutic strategy for type 2 diabetes neuropathy. PMID:23267110

  13. Release of ToxCastDB and ExpoCastDB databases

    EPA Science Inventory

    EPA has released two databases - the Toxicity Forecaster database (ToxCastDB) and a database of chemical exposure studies (ExpoCastDB) - that scientists and the public can use to access chemical toxicity and exposure data. ToxCastDB users can search and download data from over 50...

  14. EzCatDB: the enzyme reaction database, 2015 update.

    PubMed

    Nagano, Nozomi; Nakayama, Naoko; Ikeda, Kazuyoshi; Fukuie, Masaru; Yokota, Kiyonobu; Doi, Takuo; Kato, Tsuyoshi; Tomii, Kentaro

    2015-01-01

    The EzCatDB database (http://ezcatdb.cbrc.jp/EzCatDB/) has emphasized manual classification of enzyme reactions from the viewpoints of enzyme active-site structures and their catalytic mechanisms based on literature information, amino acid sequences of enzymes (UniProtKB) and the corresponding tertiary structures from the Protein Data Bank (PDB). Reaction types such as hydrolysis, transfer, addition, elimination, isomerization, hydride transfer and electron transfer have been included in the reaction classification, RLCP. This database includes information related to ligand molecules on the enzyme structures in the PDB data, classified in terms of cofactors, substrates, products and intermediates, which are also necessary to elucidate the catalytic mechanisms. Recently, the database system was updated. The 3D structures of active sites for each PDB entry can be viewed using Jmol or Rasmol software. Moreover, sequence search systems of two types were developed for the EzCatDB database: EzCat-BLAST and EzCat-FORTE. EzCat-BLAST is suitable for quick searches, adopting the BLAST algorithm, whereas EzCat-FORTE is more suitable for detecting remote homologues, adopting the algorithm for FORTE protein structure prediction software. Another system, EzMetAct, is also available to searching for major active-site structures in EzCatDB, for which PDB-formatted queries can be searched.

  15. EzCatDB: the enzyme reaction database, 2015 update.

    PubMed

    Nagano, Nozomi; Nakayama, Naoko; Ikeda, Kazuyoshi; Fukuie, Masaru; Yokota, Kiyonobu; Doi, Takuo; Kato, Tsuyoshi; Tomii, Kentaro

    2015-01-01

    The EzCatDB database (http://ezcatdb.cbrc.jp/EzCatDB/) has emphasized manual classification of enzyme reactions from the viewpoints of enzyme active-site structures and their catalytic mechanisms based on literature information, amino acid sequences of enzymes (UniProtKB) and the corresponding tertiary structures from the Protein Data Bank (PDB). Reaction types such as hydrolysis, transfer, addition, elimination, isomerization, hydride transfer and electron transfer have been included in the reaction classification, RLCP. This database includes information related to ligand molecules on the enzyme structures in the PDB data, classified in terms of cofactors, substrates, products and intermediates, which are also necessary to elucidate the catalytic mechanisms. Recently, the database system was updated. The 3D structures of active sites for each PDB entry can be viewed using Jmol or Rasmol software. Moreover, sequence search systems of two types were developed for the EzCatDB database: EzCat-BLAST and EzCat-FORTE. EzCat-BLAST is suitable for quick searches, adopting the BLAST algorithm, whereas EzCat-FORTE is more suitable for detecting remote homologues, adopting the algorithm for FORTE protein structure prediction software. Another system, EzMetAct, is also available to searching for major active-site structures in EzCatDB, for which PDB-formatted queries can be searched. PMID:25324316

  16. Nonlinear frequency compression: Influence of start frequency and input bandwidth on consonant and vowel recognition.

    PubMed

    Alexander, Joshua M

    2016-02-01

    By varying parameters that control nonlinear frequency compression (NFC), this study examined how different ways of compressing inaudible mid- and/or high-frequency information at lower frequencies influences perception of consonants and vowels. Twenty-eight listeners with mild to moderately severe hearing loss identified consonants and vowels from nonsense syllables in noise following amplification via a hearing aid simulator. Low-pass filtering and the selection of NFC parameters fixed the output bandwidth at a frequency representing a moderately severe (3.3 kHz, group MS) or a mild-to-moderate (5.0 kHz, group MM) high-frequency loss. For each group (n = 14), effects of six combinations of NFC start frequency (SF) and input bandwidth [by varying the compression ratio (CR)] were examined. For both groups, the 1.6 kHz SF significantly reduced vowel and consonant recognition, especially as CR increased; whereas, recognition was generally unaffected if SF increased at the expense of a higher CR. Vowel recognition detriments for group MS were moderately correlated with the size of the second formant frequency shift following NFC. For both groups, significant improvement (33%-50%) with NFC was confined to final /s/ and /z/ and to some VCV tokens, perhaps because of listeners' limited exposure to each setting. No set of parameters simultaneously maximized recognition across all tokens. PMID:26936574

  17. A gain and bandwidth enhanced transimpedance preamplifier for Fourier-transform ion cyclotron resonance mass spectrometry

    PubMed Central

    Lin, Tzu-Yung; Green, Roger J.; O'Connor, Peter B.

    2011-01-01

    The nature of the ion signal from a 12-T Fourier-transform ion cyclotron resonance mass spectrometer and the electronic noise were studied to further understand the electronic detection limit. At minimal cost, a new transimpedance preamplifier was designed, computer simulated, built, and tested. The preamplifier design pushes the electronic signal-to-noise performance at room temperature to the limit, because of its enhanced tolerance of the capacitance of the detection device, lower intrinsic noise, and larger flat mid-band gain (input current noise spectral density of around 1 pA/\\documentclass[12pt]{minimal}\\begin{document}$\\sqrt{\\mbox{Hz}}$\\end{document}Hz when the transimpedance is about 85 dBΩ). The designed preamplifier has a bandwidth of ∼3 kHz to 10 MHz, which corresponds to the mass-to-charge ratio, m/z, of approximately 18 to 61 k at 12 T. The transimpedance and the bandwidth can be easily adjusted by changing the value of passive components. The feedback limitation of the circuit is discussed. With the maximum possible transimpedance of 5.3 MΩ when using an 0402 surface mount resistor, the preamplifier was estimated to be able to detect ∼110 charges in a single scan. PMID:22225232

  18. Doubling of sensitivity and bandwidth in phonon-cooled hot-electron bolometer mixers

    NASA Astrophysics Data System (ADS)

    Baselmans, Jochem J. A.; Hajenius, Merlijn; Gao, Jianrong; Korte, Piet d.; Klapwijk, Teun M.; Voronov, Boris; Gol'tsman, Gregory

    2004-10-01

    NbN hot electron bolometer (HEB) mixers are at this moment the best heterodyne detectors for frequencies above 1 THz. However, the fabrication procedure of these devices is such that the quality of the interface between the NbN superconducting film and the contact structure is not under good control. This results in a contact resistance between the NbN bolometer and the contact pad. We compare identical bolometers, with different NbN - contact pad interfaces, coupled with a spiral antenna. We find that cleaning the NbN interface and adding a thin additional superconductor prior to the gold contact deposition improves the noise temperature and the bandwidth of the HEB mixers with more than a factor of 2. We obtain a DSB noise temperature of 950 K at 2.5 THz and a Gain bandwidth of 5-6 GHz. For use in real receiver systems we design small volume (0.15x1 micron) HEB mixers with a twin slot antenna. We find that these mixers combine good sensitivity (900 K at 1.6 THz) with low LO power requirement, which is 160 - 240 nW at the Si lens of the mixer. This value is larger than expected from the isothermal technique and the known losses in the lens by a factor of 3-3.5.

  19. A gain and bandwidth enhanced transimpedance preamplifier for Fourier-transform ion cyclotron resonance mass spectrometry

    SciTech Connect

    Lin, Tzu-Yung; Green, Roger J.; O'Connor, Peter B.

    2011-12-15

    The nature of the ion signal from a 12-T Fourier-transform ion cyclotron resonance mass spectrometer and the electronic noise were studied to further understand the electronic detection limit. At minimal cost, a new transimpedance preamplifier was designed, computer simulated, built, and tested. The preamplifier design pushes the electronic signal-to-noise performance at room temperature to the limit, because of its enhanced tolerance of the capacitance of the detection device, lower intrinsic noise, and larger flat mid-band gain (input current noise spectral density of around 1 pA/{radical}(Hz) when the transimpedance is about 85 dB{Omega}). The designed preamplifier has a bandwidth of {approx}3 kHz to 10 MHz, which corresponds to the mass-to-charge ratio, m/z, of approximately 18 to 61 k at 12 T. The transimpedance and the bandwidth can be easily adjusted by changing the value of passive components. The feedback limitation of the circuit is discussed. With the maximum possible transimpedance of 5.3 M{Omega} when using an 0402 surface mount resistor, the preamplifier was estimated to be able to detect {approx}110 charges in a single scan.

  20. Excellent electromagnetic wave absorption property of quaternary composites consisting of reduced graphene oxide, polyaniline and FeNi3@SiO2 nanoparticles

    NASA Astrophysics Data System (ADS)

    Ding, Xiao; Huang, Ying; Wang, Jianguo; Wu, Haiwei; Liu, Panbo

    2015-12-01

    The electromagnetic wave absorption properties of the quaternary composites consisting of reduced graphene oxide (rGO), polyaniline (PANI), FeNi3@SiO2 (FeNi3 nanocrystals encapsulated in SiO2) nanoparticles had never been reported. In this case, we prepared FeNi3@SiO2@rGO-PANI quaternary composites and TEM results shows spherical nanoparticles are well distributed on the surface of rGO-PANI nanosheets. The investigation of the electromagnetic wave absorbability reveals that the quaternary composites exhibit wide absorption bandwidth and enhanced electromagnetic wave absorption properties. The absorption bandwidth with reflection loss less than -10 dB (90% attenuation) is up to 6.64 GHz (10.08-10.80 GHz, 12.08-18.0 GHz), and the maximum reflection loss reaches about -40.18 dB at 14.0 GHz with the thickness of 2.4 mm. It is believed that the FeNi3@SiO2@rGO-PANI composites can serve as excellent electromagnetic wave absorbent and can be widely used in practice.

  1. Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys.

    PubMed

    Thuita, John K; Wolf, Kristina K; Murilla, Grace A; Bridges, Arlene S; Boykin, David W; Mutuku, James N; Liu, Qiang; Jones, Susan K; Gem, Charles O; Ching, Shelley; Tidwell, Richard R; Wang, Michael Z; Paine, Mary F; Brun, Reto

    2015-02-01

    Human African trypanosomiasis (HAT, sleeping sickness) ranks among the most neglected tropical diseases based on limited availability of drugs that are safe and efficacious, particularly against the second stage (central nervous system [CNS]) of infection. In response to this largely unmet need for new treatments, the Consortium for Parasitic Drug Development developed novel parenteral diamidines and corresponding oral prodrugs that have shown cure of a murine model of second stage HAT. As a rationale for selection of one of these compounds for further development, the pharmacokinetics and efficacy of intramuscular (IM) active diamidine 2,5-bis(5-amidino-2-pyridyl)furan (DB829; CPD-0802) and oral prodrug2,5-bis[5-(N-methoxyamidino)-2-pyridyl]furan (DB868) were compared in the vervet monkey model of second stage HAT. Treatment was initiated 28 days post-infection of monkeys with T. b. rhodesiense KETRI 2537. Results showed that IM DB829 at 5 mg/kg/day for 5 consecutive days, 5 mg/kg/day every other day for 5 doses, or 2.5 mg/kg/day for 5 consecutive days cured all monkeys (5/5). Oral DB868 was less successful, with no cures (0/2) at 3 mg/kg/day for 10 days and cure rates of 1/4 at 10 mg/kg/day for 10 days and 20 mg/kg/day for 10 days; in total, only 2/10 monkeys were cured with DB868 dose regimens. The geometric mean plasma Cmax of IM DB829 at 5 mg/kg following the last of 5 doses was 25-fold greater than that after 10 daily oral doses of DB868 at 20 mg/kg. These data suggest that the active diamidine DB829, administered IM, should be considered for further development as a potential new treatment for second stage HAT.

  2. Evaluation of 7-O-galloyl-D-sedoheptulose, isolated from Corni Fructus, in the adipose tissue of type 2 diabetic db/db mice.

    PubMed

    Park, Chan Hum; Tanaka, Takashi; Yokozawa, Takako

    2013-09-01

    The aim of the present study was to evaluate the beneficial effects of 7-O-galloyl-D-sedoheptulose (GS), isolated from Corni Fructus, using type 2 diabetic mice. GS was orally administered to db/db mice at doses of 20 and 100 mg/kg body weight per day for 6 weeks, and the effects of GS on biochemical factors in serum and adipose tissue were investigated. To define the underlying mechanism of these effects, protein expressions related to lipid metabolism, inflammation, fibrosis, and apoptosis, were measured. The results showed that levels of glucose, leptin, insulin, C-peptide, resistin, tumor necrosis factor-α, interleukin-6, triglycerides, total cholesterol, non-esterified fatty acids, high-density lipoprotein cholesterol, very low-density lipoprotein cholesterol/low-density lipoprotein cholesterol, reactive oxygen species (ROS), and thiobarbituric acid-reactive substance (TBARS) in serum were down-regulated, while adiponectin was augmented by GS treatment. In addition, the elevated lipid, ROS, and TBARS contents in adipose tissue as well as serum levels in db/db mice were significantly decreased by the oral administration of GS. From protein analysis, the decreased expressions of peroxisome proliferator activated receptor (PPAR)α, PPARγ, and B-cell lymphoma 2 were up-regulated in the adipose tissue of db/db mice. The administration of GS significantly decreased sterol regulatory element binding protein-1, nuclear factor-kappa ?>Bp65, cyclooxygenase-2, inducible nitric oxide synthase, monocyte chemotactic protein-1, intracellular adhesion molecule-1, phosphor c-Jun N-terminal kinase, activator protein-1, transforming growth factor-β1, Bax, cytochrome c, and caspase-3 expressions. These results suggest that GS acts as a regulator of oxidative stress, inflammation, fibrosis, and apoptosis in the adipose tissue of db/db mice.

  3. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice.

    PubMed

    Nagashima, Takeyuki; Shigematsu, Nobuharu; Maruki, Riyo; Urano, Yasuharu; Tanaka, Hirotsugu; Shimaya, Akiyoshi; Shimokawa, Teruhiko; Shibasaki, Masayuki

    2010-11-01

    Excessive hepatic glucose production through the gluconeogenesis pathway is partially responsible for the elevated glucose levels observed in patients with type 2 diabetes mellitus (T2DM). The forkhead transcription factor forkhead box O1 (Foxo1) plays a crucial role in mediating the effect of insulin on hepatic gluconeogenesis. Here, using a db/db mouse model, we demonstrate the effectiveness of Foxo1 inhibitor, an orally active small-molecule compound, as a therapeutic drug for treating T2DM. Using mass spectrometric affinity screening, we discovered a series of compounds that bind to Foxo1, identifying among them the compound, 5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (AS1842856), which potently inhibits human Foxo1 transactivation and reduces glucose production through the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. Oral administration of AS1842856 to diabetic db/db mice led to a drastic decrease in fasting plasma glucose level via the inhibition of hepatic gluconeogenic genes, whereas administration to normal mice had no effect on the fasting plasma glucose level. Treatment with AS1842856 also suppressed an increase in plasma glucose level caused by pyruvate injection in both normal and db/db mice. Taken together, these findings indicate that the Foxo1 inhibitor represents a new class of drugs for use in treating T2DM. PMID:20736318

  4. A broadband DC to 20 GHz 3-bit MEMS digital attenuator

    NASA Astrophysics Data System (ADS)

    Sun, Junfeng; Zhu, Jian; Jiang, Lili; Yu, Yuanwei; Li, Zhiqun

    2016-05-01

    A 3-bit microelectromechanical system (MEMS) digital attenuator is designed with 0–20 GHz bandwidth. The attenuation ranges from 0 to 35 dB with 5 dB step. The attenuator, with the coplanar waveguide (CPW), is implemented by surface sacrificial layer technology. The DC-contact MEMS switches with three contact dimples are symmetrically placed around the T type resistor network, making the switches minimum in number and the structure compact. Through the lumped parameter method, the attenuator has good terminal matches in different attenuation states. The test results show that eight different attenuation states are realized within 0–20 GHz. The attenuation deviation is less than  ±5%, the insertion loss is less than 1.7 dB and the voltage standing wave rations is less than 1.4 under most of the attenuation states. With the MEMS switches and CPW being adopted, the attenuator has the advantages of higher linearity, lower insertion loss and power consumption. The chip size is about 3.2 mm2 including the pad. This work was supported by the International Science & Technology Cooperation Program of China (2013DFB10300).

  5. A broadband DC to 20 GHz 3-bit MEMS digital attenuator

    NASA Astrophysics Data System (ADS)

    Sun, Junfeng; Zhu, Jian; Jiang, Lili; Yu, Yuanwei; Li, Zhiqun

    2016-05-01

    A 3-bit microelectromechanical system (MEMS) digital attenuator is designed with 0-20 GHz bandwidth. The attenuation ranges from 0 to 35 dB with 5 dB step. The attenuator, with the coplanar waveguide (CPW), is implemented by surface sacrificial layer technology. The DC-contact MEMS switches with three contact dimples are symmetrically placed around the T type resistor network, making the switches minimum in number and the structure compact. Through the lumped parameter method, the attenuator has good terminal matches in different attenuation states. The test results show that eight different attenuation states are realized within 0-20 GHz. The attenuation deviation is less than  ±5%, the insertion loss is less than 1.7 dB and the voltage standing wave rations is less than 1.4 under most of the attenuation states. With the MEMS switches and CPW being adopted, the attenuator has the advantages of higher linearity, lower insertion loss and power consumption. The chip size is about 3.2 mm2 including the pad. This work was supported by the International Science & Technology Cooperation Program of China (2013DFB10300).

  6. High Bandwidth Electro-optic Scanner for Optical Data Storage

    NASA Astrophysics Data System (ADS)

    Zhai, Jinhui; Huang, Yuhong; Schroeck, Steve; Messner, W.; Stancil, Daniel D.; Schlesinger, T. E.

    2000-02-01

    Beam deflectors can be used as fine tracking actuators to improve track access time and data rate in future high performance optical disk drives. In this paper we report on the use of an electro-optic (EO) scanner for optical data storage. Track following has been accomplished using this EO actuator with a servo bandwidth of 200 kHz, and single-stage high-speed track switching/following has been demonstrated in a new optical head tracking system with reduced offset. A fine tracking experiment has also been demonstrated using an EO actuator with a voice coil motor (VCM) actuator to extend the fine tracking range. A new compensator design method, the PQ method, has been used for this scanner/VCM compound actuator system. Significant improvements in track switching/following speed are demonstrated with the scanner/VCM compound actuator as compared to tracking with the VCM actuator alone.

  7. Fudge: a high-bandwidth fusion diagnostic of the NIF

    SciTech Connect

    Moran, M. J., LLNL

    1998-06-02

    Diagnostics for the National Ignition Facility (NIF)/Inertial Confinement Fusion (ICF) program must include good characterization of the fusion source. Ideally, diagnostics would measure the spatially-resolved history of the fusion reaction rate and temperature. Existing diagnostics can satisfy this goal only partially. One class of new techniques that could play a major role in high-yield diagnostics is measurements based on fusion {gamma} rays. The Fusion Diagnostic Gamma Experiment (FUDGE) can be used to perform energy-resolved measurements of (D,T) fusion reaction rates This diagnostic is based on the 16 7-MeV {gamma} rays that are produced by (D,T) fusion. The {gamma} rays are free of spectral dispersion and can be detected with a high bandwidth Cherenkov detector. A simple magnetic monochromator selects signals from the 16 7-MeV {gamma} rays and reduces background signals from non-fusion {gamma} rays.

  8. Auction-based bandwidth allocation in the Internet

    NASA Astrophysics Data System (ADS)

    Wei, Jiaolong; Zhang, Chi

    2002-07-01

    It has been widely accepted that auctioning which is the pricing approach with minimal information requirement is a proper tool to manage scare network resources. Previous works focus on Vickrey auction which is incentive compatible in classic auction theory. In the beginning of this paper, the faults of the most representative auction-based mechanisms are discussed. And then a new method called uniform-price auction (UPA), which has the simplest auction rule is proposed and it's incentive compatibility in the network environment is also proved. Finally, the basic mode is extended to support applications which require minimum bandwidth guarantees for a given time period by introducing derivative market, and a market mechanism for network resource allocation which is predictable, riskless, and simple for end-users is completed.

  9. High-bandwidth continuous-flow arc furnace

    DOEpatents

    Hardt, David E.; Lee, Steven G.

    1996-01-01

    A high-bandwidth continuous-flow arc furnace for stream welding applications includes a metal mass contained in a crucible having an orifice. A power source charges an electrode for generating an arc between the electrode and the mass. The arc heats the metal mass to a molten state. A pressurized gas source propels the molten metal mass through the crucible orifice in a continuous stream. As the metal is ejected, a metal feeder replenishes the molten metal bath. A control system regulates the electrode current, shielding gas pressure, and metal source to provide a continuous flow of molten metal at the crucible orifice. Independent control over the electrode current and shield gas pressure decouples the metal flow temperature and the molten metal flow rate, improving control over resultant weld characteristics.

  10. High-bandwidth continuous-flow arc furnace

    DOEpatents

    Hardt, D.E.; Lee, S.G.

    1996-08-06

    A high-bandwidth continuous-flow arc furnace for stream welding applications includes a metal mass contained in a crucible having an orifice. A power source charges an electrode for generating an arc between the electrode and the mass. The arc heats the metal mass to a molten state. A pressurized gas source propels the molten metal mass through the crucible orifice in a continuous stream. As the metal is ejected, a metal feeder replenishes the molten metal bath. A control system regulates the electrode current, shielding gas pressure, and metal source to provide a continuous flow of molten metal at the crucible orifice. Independent control over the electrode current and shield gas pressure decouples the metal flow temperature and the molten metal flow rate, improving control over resultant weld characteristics. 4 figs.

  11. An improved harmony search algorithm with dynamically varying bandwidth

    NASA Astrophysics Data System (ADS)

    Kalivarapu, J.; Jain, S.; Bag, S.

    2016-07-01

    The present work demonstrates a new variant of the harmony search (HS) algorithm where bandwidth (BW) is one of the deciding factors for the time complexity and the performance of the algorithm. The BW needs to have both explorative and exploitative characteristics. The ideology is to use a large BW to search in the full domain and to adjust the BW dynamically closer to the optimal solution. After trying a series of approaches, a methodology inspired by the functioning of a low-pass filter showed satisfactory results. This approach was implemented in the self-adaptive improved harmony search (SIHS) algorithm and tested on several benchmark functions. Compared to the existing HS algorithm and its variants, SIHS showed better performance on most of the test functions. Thereafter, the algorithm was applied to geometric parameter optimization of a friction stir welding tool.

  12. High Bandwidth Short Stroke Rotary Fast Tool Servo

    SciTech Connect

    Montesanti, R C; Trumper, D L

    2003-08-22

    This paper presents the design and performance of a new rotary fast tool servo (FTS) capable of developing the 40 g's tool tip acceleration required to follow a 5 micron PV sinusoidal surface at 2 kHz with a planned accuracy of 50 nm, and having a full stroke of 50 micron PV at lower frequencies. Tests with de-rated power supplies have demonstrated a closed-loop unity-gain bandwidth of 2 kHz with 20 g's tool acceleration, and we expect to achieve 40 g's with supplies providing {+-} 16 Amp to the Lorentz force actuator. The use of a fast tool servo with a diamond turning machine for producing non-axisymmetric or textured surfaces on a workpiece is well known. Our new rotary FTS was designed to specifically accommodate fabricating prescription textured surfaces on 5 mm diameter spherical target components for High Energy Density Physics experiments on the National Ignition Facility Laser (NIF).

  13. A neural amplifier with high programmable gain and tunable bandwidth.

    PubMed

    Perlin, Gayatri E; Sodagar, Amir M; Wise, Kensall D

    2008-01-01

    A neural recording amplifier having programmable gain and bandwidth is presented. The gain can be digitally programmed using 6 bits from 100x to 1100x in steps of 100x. The low-frequency cutoff can be varied from less than 10Hz to above 100Hz to accept or reject field potentials while the high-frequency cutoff is fixed at 9kHz. The input referred noise of this amplifier is 4.8microV(rms) and it consumes 50microW operating from +/-1.5V. Implemented in a 0.5microm technology, the amplifier occupies an area of 0.098mm(2). This amplifier has been successfully demonstrated in-vivo and compared to a commercial amplifier.

  14. Wide-Bandwidth Capture of Wire-Scanner Signals

    SciTech Connect

    Gruchalla, Michael E.; Gilpatrick, John D.; Sedillo, James Daniel; Martinez, Derwin

    2012-05-16

    Integrated charge collected on the sense wires of wire-scanner systems utilized to determine beam profile is generally the parameter of interest. The LANSCE application requires capturing the charge information macropulse-by-macropulse with macropulse lengths as long as 700 {micro}s at a maximum macropulse rate of 120 Hz. Also, for the LANSCE application, it is required that the integration be performed in a manner that does not require integrator reset between macropulses. Due to the long macropulse which must be accommodated and the 8.33 ms minimum pulse period, a simple R-C integrator cannot be utilized since there is insufficient time between macropulses to allow the integrator to adequately recover. The application of wide analog bandwidth to provide accurate pulse-by-pulse capture of the wire signals with digital integration of the wire signals to determine captured charge at each macropulse in applications with comparatively long macropulses and high pulse repetition rates is presented.

  15. Broadening the interface bandwidth in simulation based training

    NASA Technical Reports Server (NTRS)

    Somers, Larry E.

    1989-01-01

    Currently most computer based simulations rely exclusively on computer generated graphics to create the simulation. When training is involved, the method almost exclusively used to display information to the learner is text displayed on the cathode ray tube. MICROEXPERT Systems is concentrating on broadening the communications bandwidth between the computer and user by employing a novel approach to video image storage combined with sound and voice output. An expert system is used to combine and control the presentation of analog video, sound, and voice output with computer based graphics and text. Researchers are currently involved in the development of several graphics based user interfaces for NASA, the U.S. Army, and the U.S. Navy. Here, the focus is on the human factors considerations, software modules, and hardware components being used to develop these interfaces.

  16. Transformation optics for antennas: why limit the bandwidth with metamaterials?

    PubMed

    Quevedo-Teruel, Oscar; Tang, Wenxuan; Mitchell-Thomas, Rhiannon C; Dyke, Amy; Dyke, Hazel; Zhang, Lianhong; Haq, Sajad; Hao, Yang

    2013-01-01

    In the last decade, a technique termed transformation optics has been developed for the design of novel electromagnetic devices. This method defines the exact modification of magnetic and dielectric constants required, so that the electromagnetic behaviour remains invariant after a transformation to a new coordinate system. Despite the apparently infinite possibilities that this mathematical tool introduces, one restriction has repeatedly recurred since its conception: limited frequency bands of operation. Here we circumvent this problem with the proposal of a full dielectric implementation of a transformed planar hyperbolic lens which retains the same focusing properties of an original curved lens. The redesigned lens demonstrates operation with high directivity and low side lobe levels for an ultra-wide band of frequencies, spanning over three octaves. The methodology proposed in this paper can be applied to revolutionise the design of many electromagnetic devices overcoming bandwidth limitations.

  17. High Bandwidth Optical Links for Micro-Satellite Support

    NASA Technical Reports Server (NTRS)

    Chao, Tien-Hsin (Inventor); Wilson, Keith E. (Inventor); Coste, Keith (Inventor)

    2016-01-01

    A method, systems, apparatus and device enable high bandwidth satellite communications. An onboard tracking detector, installed in a low-earth orbit satellite, detects a position of an incoming optical beam received/transmitted from a first ground station of one or more ground stations. Tracker electronics determine orientation information of the incoming optical beam based on the position. Control electronics receive the orientation information from the tracker electronics, and control a waveguide drive electronics. The waveguide drive electronics control a voltage that is provided to an electro-optic waveguide beam steering device. The electro-optic waveguide beam steering device steers an outgoing optical beam to one of the one or more ground stations based on the voltage.

  18. Transformation optics for antennas: why limit the bandwidth with metamaterials?

    PubMed Central

    Quevedo-Teruel, Oscar; Tang, Wenxuan; Mitchell-Thomas, Rhiannon C.; Dyke, Amy; Dyke, Hazel; Zhang, Lianhong; Haq, Sajad; Hao, Yang

    2013-01-01

    In the last decade, a technique termed transformation optics has been developed for the design of novel electromagnetic devices. This method defines the exact modification of magnetic and dielectric constants required, so that the electromagnetic behaviour remains invariant after a transformation to a new coordinate system. Despite the apparently infinite possibilities that this mathematical tool introduces, one restriction has repeatedly recurred since its conception: limited frequency bands of operation. Here we circumvent this problem with the proposal of a full dielectric implementation of a transformed planar hyperbolic lens which retains the same focusing properties of an original curved lens. The redesigned lens demonstrates operation with high directivity and low side lobe levels for an ultra-wide band of frequencies, spanning over three octaves. The methodology proposed in this paper can be applied to revolutionise the design of many electromagnetic devices overcoming bandwidth limitations. PMID:23712699

  19. Transformation optics for antennas: why limit the bandwidth with metamaterials?

    NASA Astrophysics Data System (ADS)

    Quevedo-Teruel, Oscar; Tang, Wenxuan; Mitchell-Thomas, Rhiannon C.; Dyke, Amy; Dyke, Hazel; Zhang, Lianhong; Haq, Sajad; Hao, Yang

    2013-05-01

    In the last decade, a technique termed transformation optics has been developed for the design of novel electromagnetic devices. This method defines the exact modification of magnetic and dielectric constants required, so that the electromagnetic behaviour remains invariant after a transformation to a new coordinate system. Despite the apparently infinite possibilities that this mathematical tool introduces, one restriction has repeatedly recurred since its conception: limited frequency bands of operation. Here we circumvent this problem with the proposal of a full dielectric implementation of a transformed planar hyperbolic lens which retains the same focusing properties of an original curved lens. The redesigned lens demonstrates operation with high directivity and low side lobe levels for an ultra-wide band of frequencies, spanning over three octaves. The methodology proposed in this paper can be applied to revolutionise the design of many electromagnetic devices overcoming bandwidth limitations.

  20. Description of a New 400 MHZ Bandwidth Chirp Transform Spectrometer

    NASA Astrophysics Data System (ADS)

    Paganini, Lucas; Hartogh, Paul

    A new chirp transform spectrometer (CTS) with a bandwidth of 400 MHz and a spectral resolution of 100 kHz has been developed. The CTS is deviced using a digital chirp generator and a preprocessing unit based on a Complementary Metal Oxide Semiconductor (CMOS) and an Application-Specific Integrated Circuit (ASIC). A build in PC 104 computer handles the process control and the external communication via Ethernet and a Transistor-Transistor Logic (TTL) interface. The CTS has been applied to atmospheric science, i.e., a 25-K noise temperature, 22-GHz water vapor, and a 142-GHz ozone system. Astronomical observations have been performed using the Heinrich Hertz submillimeter telescope. In this paper, we describe the function of the CTS and provide information about its functional performance.

  1. High bandwidth synaptic communication and frequency tracking in human neocortex.

    PubMed

    Testa-Silva, Guilherme; Verhoog, Matthijs B; Linaro, Daniele; de Kock, Christiaan P J; Baayen, Johannes C; Meredith, Rhiannon M; De Zeeuw, Chris I; Giugliano, Michele; Mansvelder, Huibert D

    2014-11-01

    Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than rodent synapses. To test this, we recorded from connected pairs of pyramidal neurons in acute brain slices of adult human and mouse temporal cortex and probed the dynamical properties of use-dependent plasticity. We found that human synaptic connections were purely depressing and that they recovered three to four times more swiftly from depression than synapses in rodent neocortex. Thereby, during realistic spike trains, the temporal resolution of synaptic information exchange in human synapses substantially surpasses that in mice. Using information theory, we calculate that information transfer between human pyramidal neurons exceeds that of mouse pyramidal neurons by four to nine times, well into the beta and gamma frequency range. In addition, we found that human principal cells tracked fine temporal features, conveyed in received synaptic inputs, at a wider bandwidth than for rodents. Action potential firing probability was reliably phase-locked to input transients up to 1,000 cycles/s because of a steep onset of action potentials in human pyramidal neurons during spike trains, unlike in rodent neurons. Our data show that, in contrast to the widely held views of limited information transfer in rodent depressing synapses, fast recovering synapses of human neurons can actually transfer substantial amounts of information during spike trains. In addition, human pyramidal neurons are equipped to encode high synaptic information content. Thus, adult human cortical microcircuits relay information at a wider bandwidth than rodent microcircuits.

  2. Adaptive data filtering of inertial sensors with variable bandwidth.

    PubMed

    Alam, Mushfiqul; Rohac, Jan

    2015-02-02

    MEMS (micro-electro-mechanical system)-based inertial sensors, i.e., accelerometers and angular rate sensors, are commonly used as a cost-effective solution for the purposes of navigation in a broad spectrum of terrestrial and aerospace applications. These tri-axial inertial sensors form an inertial measurement unit (IMU), which is a core unit of navigation systems. Even if MEMS sensors have an advantage in their size, cost, weight and power consumption, they suffer from bias instability, noisy output and insufficient resolution. Furthermore, the sensor's behavior can be significantly affected by strong vibration when it operates in harsh environments. All of these constitute conditions require treatment through data processing. As long as the navigation solution is primarily based on using only inertial data, this paper proposes a novel concept in adaptive data pre-processing by using a variable bandwidth filtering. This approach utilizes sinusoidal estimation to continuously adapt the filtering bandwidth of the accelerometer's data in order to reduce the effects of vibration and sensor noise before attitude estimation is processed. Low frequency vibration generally limits the conditions under which the accelerometers can be used to aid the attitude estimation process, which is primarily based on angular rate data and, thus, decreases its accuracy. In contrast, the proposed pre-processing technique enables using accelerometers as an aiding source by effective data smoothing, even when they are affected by low frequency vibration. Verification of the proposed concept is performed on simulation and real-flight data obtained on an ultra-light aircraft. The results of both types of experiments confirm the suitability of the concept for inertial data pre-processing.

  3. AmoebaDB and MicrosporidiaDB: functional genomic resources for Amoebozoa and Microsporidia species

    PubMed Central

    Aurrecoechea, Cristina; Barreto, Ana; Brestelli, John; Brunk, Brian P.; Caler, Elisabet V.; Fischer, Steve; Gajria, Bindu; Gao, Xin; Gingle, Alan; Grant, Greg; Harb, Omar S.; Heiges, Mark; Iodice, John; Kissinger, Jessica C.; Kraemer, Eileen T.; Li, Wei; Nayak, Vishal; Pennington, Cary; Pinney, Deborah F.; Pitts, Brian; Roos, David S.; Srinivasamoorthy, Ganesh; Stoeckert, Christian J.; Treatman, Charles; Wang, Haiming

    2011-01-01

    AmoebaDB (http://AmoebaDB.org) and MicrosporidiaDB (http://MicrosporidiaDB.org) are new functional genomic databases serving the amoebozoa and microsporidia research communities, respectively. AmoebaDB contains the genomes of three Entamoeba species (E. dispar, E. invadens and E. histolityca) and microarray expression data for E. histolytica. MicrosporidiaDB contains the genomes of Encephalitozoon cuniculi, E. intestinalis and E. bieneusi. The databases belong to the National Institute of Allergy and Infectious Diseases (NIAID) funded EuPathDB (http://EuPathDB.org) Bioinformatics Resource Center family of integrated databases and assume the same architectural and graphical design as other EuPathDB resources such as PlasmoDB and TriTrypDB. Importantly they utilize the graphical strategy builder that affords a database user the ability to ask complex multi-data-type questions with relative ease and versatility. Genomic scale data can be queried based on BLAST searches, annotation keywords and gene ID searches, GO terms, sequence motifs, protein characteristics, phylogenetic relationships and functional data such as transcript (microarray and EST evidence) and protein expression data. Search strategies can be saved within a user’s profile for future retrieval and may also be shared with other researchers using a unique strategy web address. PMID:20974635

  4. High-efficiency and wideband interlayer grating couplers in multilayer Si/SiO2/SiN platform for 3D integration of optical functionalities.

    PubMed

    Sodagar, Majid; Pourabolghasem, Reza; Eftekhar, Ali A; Adibi, Ali

    2014-07-14

    We have designed interlayer grating couplers with single/double metallic reflectors for Si/SiO(2)/SiN multilayer material platform. Out-of-plane diffractive grating couplers separated by 1.6 μm thick buffer SiO(2) layer are vertically stacked against each other in Si and SiN layers. Geometrical optimization using genetic algorithm coupled with electromagnetic simulations using two-dimensional (2D) finite element method (FEM) results in coupler designs with high peak coupling efficiency of up to 89% for double- mirror and 64% for single-mirror structures at telecom wavelength. Also, 3-dB bandwidths of 40 nm and 50 nm are theoretically predicted for the two designs, respectively. We have fabricated the grating coupler structure with single mirror. Measured values for insertion loss and 3-dB bandwidth in the fabricated single-mirror coupler confirms the theoretical results. This opens up the possibility of low-loss 3D dense integration of optical functionalities in hybrid material platforms.

  5. Large-Aperture Wide-Bandwidth Anti-Reflection-Coated Silicon Lenses for Millimeter Wavelengths

    NASA Technical Reports Server (NTRS)

    Datta, R.; Munson, C. D.; Niemack, M. D.; McMahon, J. J.; Britton, J.; Wollack, E. J.; Beall, J.; Devlin, M. J.; Fowler, J.; Gallardo, P.; Hubmayr, J.; Irwin, K.; Newburgh, L.; Nibarger, J. P.; Page, L.; Quijada, M. A.; Schmitt, B. L.; Staggs, S. T.; Thornton, R.; Zhang, L.

    2013-01-01

    The increasing scale of cryogenic detector arrays for sub-millimeter and millimeter wavelength astrophysics has led to the need for large aperture, high index of refraction, low loss, cryogenic refracting optics. Silicon with n = 3.4, low loss, and relatively high thermal conductivity is a nearly optimal material for these purposes, but requires an antireflection (AR) coating with broad bandwidth, low loss, low reflectance, and a matched coffecient of thermal expansion. We present an AR coating for curved silicon optics comprised of subwavelength features cut into the lens surface with a custom three axis silicon dicing saw. These features constitute a metamaterial that behaves as a simple dielectric coating. We have fabricated and coated silicon lenses as large as 33.4 cm in diameter with coatings optimized for use between 125-165 GHz. Our design reduces average reflections to a few tenths of a percent for angles of incidence up to 30 deg. with low cross-polarization. We describe the design, tolerance, manufacture, and measurements of these coatings and present measurements of the optical properties of silicon at millimeter wavelengths at cryogenic and room temperatures. This coating and lens fabrication approach is applicable from centimeter to sub-millimeter wavelengths and can be used to fabricate coatings with greater than octave bandwidth.

  6. Large-aperture Wide-bandwidth Antireflection-coated Silicon Lenses for Millimeter Wavelengths

    NASA Technical Reports Server (NTRS)

    Datta, R.; Munson, C. D.; Niemack, M. D.; McMahon, J. J.; Britton, J.; Wollack, Edward J.; Beall, J.; Devlin, M. J.; Fowler, J.; Gallardo, P.; Hubmayr, J.; Irwin, K.; Newburgh, L.; Nibarger, J. P.; Page, L.; Quijada, Manuel A.; Schmitt, B. L.; Staggs, S. T.; Thornton, R.; Zhang, L.

    2013-01-01

    The increasing scale of cryogenic detector arrays for submillimeter and millimeter wavelength astrophysics has led to the need for large aperture, high index of refraction, low loss, cryogenic refracting optics. Silicon with n 3.4, low loss, and high thermal conductivity is a nearly optimal material for these purposes but requires an antireflection (AR) coating with broad bandwidth, low loss, low reflectance, and a matched coefficient of thermal expansion. We present an AR coating for curved silicon optics comprised of subwavelength features cut into the lens surface with a custom three-axis silicon dicing saw. These features constitute a metamaterial that behaves as a simple dielectric coating.We have fabricated silicon lenses as large as 33.4 cm in diameter with micromachined layers optimized for use between 125 and 165 GHz. Our design reduces average reflections to a few tenths of a percent for angles of incidence up to 30deg with low cross polarization.We describe the design, tolerance, manufacture, and measurements of these coatings and present measurements of the optical properties of silicon at millimeter wavelengths at cryogenic and room temperatures. This coating and lens fabrication approach is applicable from centimeter to submillimeter wavelengths and can be used to fabricate coatings with greater than octave bandwidth.

  7. Auditory masking in three pinnipeds: Aerial critical ratios and direct critical bandwidth measurements

    NASA Astrophysics Data System (ADS)

    Southall, Brandon L.; Schusterman, Ronald J.; Kastak, David

    2003-09-01

    This study expands the limited understanding of pinniped aerial auditory masking and includes measurements at some of the relatively low frequencies predominant in many pinniped vocalizations. Behavioral techniques were used to obtain aerial critical ratios (CRs) within a hemianechoic chamber for a northern elephant seal (Mirounga angustirostris), a harbor seal (Phoca vitulina), and a California sea lion (Zalophus californianus). Simultaneous, octave-band noise maskers centered at seven test frequencies (0.2-8.0 kHz) were used to determine aerial CRs. Narrower and variable bandwidth masking noise was also used in order to obtain direct critical bandwidths (CBWs). The aerial CRs are very similar in magnitude and in frequency-specific differences (increasing gradually with test frequency) to underwater CRs for these subjects, demonstrating that pinniped cochlear processes are similar both in air and water. While, like most mammals, these pinniped subjects apparently lack specialization for enhanced detection of specific frequencies over masking noise, they consistently detect signals across a wide range of frequencies at relatively low signal-to-noise ratios. Direct CBWs are 3.2 to 14.2 times wider than estimated based on aerial CRs. The combined masking data are significant in terms of assessing aerial anthropogenic noise impacts, effective aerial communicative ranges, and amphibious aspects of pinniped cochlear mechanics.

  8. Investigation of the effects of bandwidth and time delay on helicopter roll-axis handling qualities

    NASA Technical Reports Server (NTRS)

    Blanken, Chris L.; Pausder, Heinz-Jurgen

    1994-01-01

    Several years of cooperative research conducted under the U.S./German Memorandum of Understanding (MOU) in helicopter aeromechanics have recently resulted in a successful handling qualities study. The focus of this cooperative research has been the effect of time delays in a high bandwidth vehicle on handling qualities. The jointly performed study included the use of U.S. ground-based simulation and German in-flight simulation facilities. The NASA-Ames Vertical Motion Simulator (VMS) was used to develop a high bandwidth slalom tracking task which took into consideration the constraints of the facilities. The VMS was used to define a range of the test parameters and to perform initial handling qualities evaluations. The flight tests were conducted using DLR's variable-stability BO 105 S3 Advanced Technology Testing Helicopter System (ATTHeS). Configurations included a rate command and an attitude command response system with added time delays of up to 160 milliseconds over the baseline and band width values between 1.5 and 4.5 rad/sec. Sixty-six evaluations were performed in about 25 hours of flight time during ten days of testing. The results indicate a need to more tightly constrain the allowable roll axis phase delay for the Level 1 and Level 2 requirements in the U.S. Army's specification for helicopter handling qualities Aeronautical Design Standard (ADS)-33C.

  9. A new low voltage level-shifted FVF current mirror with enhanced bandwidth and output resistance

    NASA Astrophysics Data System (ADS)

    Aggarwal, Bhawna; Gupta, Maneesha; Gupta, Anil Kumar; Sangal, Ankur

    2016-10-01

    This paper proposes a new high-performance level-shifted flipped voltage follower (LSFVF) based low-voltage current mirror (CM). The proposed CM utilises the low-supply voltage and low-input resistance characteristics of a flipped voltage follower (FVF) CM. In the proposed CM, level-shifting configuration is used to obtain a wide operating current range and resistive compensation technique is employed to increase the operating bandwidth. The peaking in frequency response is reduced by using an additional large MOSFET. Moreover, a very high output resistance (in GΩ range) along with low-current transfer error is achieved through super-cascode configuration for a wide current range (0-440 µA). Small signal analysis is carried out to show the improvements achieved at each step. The proposed CM is simulated by Mentor Graphics Eldospice in TSMC 0.18 µm CMOS, BSIM3 and Level 53 technology. In the proposed CM, a bandwidth of 6.1799 GHz, 1% settling time of 0.719 ns, input and output resistances of 21.43 Ω and 1.14 GΩ, respectively, are obtained with a single supply voltage of 1 V. The layout of the proposed CM has been designed and post-layout simulation results have been shown. The post-layout simulation results for Monte Carlo and temperature analysis have also been included to show the reliability of the CM against the variations in process parameters and temperature changes.

  10. NaoXinTong Inhibits the Development of Diabetic Retinopathy in db/db Mice

    PubMed Central

    Liu, Mengyang; Pan, Quan; Chen, Yuanli; Yang, Xiaoxiao; Zhao, Buchang; Jia, Lifu; Zhu, Yan; Han, Jihong; Li, Xiaoju; Duan, Yajun

    2015-01-01

    Buchang NaoXinTong capsule (NXT) is a Chinese Materia Medica standardized product extracted from 16 Chinese traditional medical herbs and widely used for treatment of patients with cerebrovascular and cardiovascular diseases in China. Formation of microaneurysms plays an important role in the development of diabetic retinopathy. In this study, we investigated if  NXT can protect diabetic mice against the development of diabetic retinopathy. The db/db mice (~6 weeks old), a diabetic animal model, were divided into two groups and fed normal chow or plus NXT for 14 weeks. During the treatment, fasting blood glucose levels were monthly determined. After treatment, retinas were collected to determine retinal thickness, accumulation of carbohydrate macromolecules, and caspase-3 (CAS-3) expression. Our results demonstrate that administration of NXT decreased fasting blood glucose levels. Associated with the decreased glucose levels, NXT blocked the diabetes-induced shrink of multiple layers, such as photoreceptor layer and outer nuclear/plexiform layers, in the retina. NXT also inhibited the diabetes-induced expression of CAS-3 protein and mRNA, MMP-2/9 and TNFα mRNA, accumulation of carbohydrate macromolecules, and formation of acellular capillaries in the retina. Taken together, our study shows that NXT can inhibit the development of diabetic retinopathy and suggests a new potential application of NXT in clinic. PMID:25821481

  11. Netest: A Tool to Measure the Maximum Burst Size, Available Bandwidth and Achievable Throughput

    SciTech Connect

    Jin, Guojun; Tierney, Brian

    2003-01-31

    Distinguishing available bandwidth and achievable throughput is essential for improving network applications' performance. Achievable throughput is the throughput considering a number of factors such as network protocol, host speed, network path, and TCP buffer space, where as available bandwidth only considers the network path. Without understanding this difference, trying to improve network applications' performance is like ''blind men feeling the elephant'' [4]. In this paper, we define and distinguish bandwidth and throughput, and debate which part of each is achievable and which is available. Also, we introduce and discuss a new concept - Maximum Burst Size that is crucial to the network performance and bandwidth sharing. A tool, netest, is introduced to help users to determine the available bandwidth, and provides information to achieve better throughput with fairness of sharing the available bandwidth, thus reducing misuse of the network.

  12. A variable bandwidth assignment scheme for the Land Mobile Satellite experiment

    NASA Technical Reports Server (NTRS)

    Yan, T.-Y.; Li, V. O. K.

    1985-01-01

    The Mobile Satellite Experiment is a proposed experimental satellite-based communications network which provides data and voice communications to mobile terminals dispersed in geographically dispersed areas. In this paper, an analytical model is developed to calculate the performance of a Variable Bandwidth Assignment (VBA) Scheme. Under this scheme, the satellite channel bandwidth is dynamically reassigned so that a message may be transmitted in the shortest possible time. To transmit a long message, message channels will be reconfigured to have more bandwidth such that the transmission time is reduced, while to transmit a short message, the channel bandwidth will be shrunk such that the released bandwidth can be used to serve other messages. The model is illustrated with numerical examples. It is shown that a VBA scheme can achieve considerable improvement in transmission delays over a Fixed Bandwidth Assignment Scheme.

  13. Three-dimensional (3D) α-Fe2O3/polypyrrole (PPy) nanocomposite for effective electromagnetic absorption

    NASA Astrophysics Data System (ADS)

    Jiang, Wanchun; Sun, Mengxiao; Zhang, Kun; Wu, Fan; Xie, Aming; Wang, Mingyang

    2016-06-01

    The lightweight and 3-dimensional reticulated α-Fe2O3/PPy hybrids were successfully fabricated via a facile one-pot polyreaction. The measured complex permittivity and microwave attenuation performance suggest that the dielectric properties of PPy can be regulated by the mass ratio of added α-Fe2O3. The two dielectric resonance peaks of complex permittivity can be ascribed to the interface capacitor-like structure. An equivalent circuit model was established to explain the nonlinear resonance behavior of the α-Fe2O3/PPy wax composites. The addition of α-Fe2O3 properly tuned the dielectric constant to endow the composites with highly efficient microwave absorption. The minimum reflection loss of α-Fe2O3/PPy wax composites were enhanced to nearly -29dB with an effective bandwidth (RL≤ - 10dB) up to 5.0GHz. The numerical method was proposed to calculate the optimum thickness for minimum RL at expected frequency by detailed investigation on the transmission formula. Moreover, the required thickness for optimum absorption efficiency at expected frequency can be obtained directly.

  14. Microwave dielectric properties of Ba(Zn1/3Ta2 / 3)O3 for application in high power waveguide window

    NASA Astrophysics Data System (ADS)

    Sindam, Bashaiah; Raju, K. C. James

    2016-04-01

    Higher dielectric constant, low dielectric loss and good transmission characteristics have been the goal for developing the ceramic waveguide window for high power window applications. The choice of materials having high k with low dielectric loss and reduced window size is key parameters to achieve maximum microwave transmission without unleashing microwave dissipation. The microwave dielectric properties of synthesized Ba(Zn1/3Ta2 / 3)O3 (BZT) ceramics have been studied for high power window applications. The structural studies are correlated with microwave dielectric properties of BZT. The maximum values of dielectric constant ɛr = 30, Q × f0 = 102 THz and near zero temperature coefficient of resonance frequency were obtained for BZT ceramics sintered at the temperature of 1550 °C for 4 h. The measured results are used to design a tapered transition from air filled waveguide to narrow (reduced width and height) dielectric filled waveguide using Heckens linear taper at a specific frequency. The simulation result shows that the lower reflection loss is obtained for the tapered transition of the narrow BZT window as compared to the standard waveguide BZT window. The return loss of -34 dB is obtained for S-band waveguide window with a bandwidth of 675 MHz. The return loss observed in the narrow BZT window is -46 dB with a bandwidth of 570 MHz at a center frequency of 3.63 GHz. Most of the disadvantages in conventional windows will be rectified using the design of the taper transion employing narrow waveguide window in high power applications. Contribution to the Topical Issue "Materials for Dielectric Applications", edited by Maciej Jaroszewski and Sabu Thomas.

  15. The Kepler DB, a Database Management System for Arrays, Sparse Arrays and Binary Data

    NASA Technical Reports Server (NTRS)

    McCauliff, Sean; Cote, Miles T.; Girouard, Forrest R.; Middour, Christopher; Klaus, Todd C.; Wohler, Bill

    2010-01-01

    The Kepler Science Operations Center stores pixel values on approximately six million pixels collected every 30-minutes, as well as data products that are generated as a result of running the Kepler science processing pipeline. The Kepler Database (Kepler DB) management system was created to act as the repository of this information. After one year of ight usage, Kepler DB is managing 3 TiB of data and is expected to grow to over 10 TiB over the course of the mission. Kepler DB is a non-relational, transactional database where data are represented as one dimensional arrays, sparse arrays or binary large objects. We will discuss Kepler DB's APIs, implementation, usage and deployment at the Kepler Science Operations Center.

  16. Increasing the bandwidth of resonant gravitational antennas: the case of explorer.

    PubMed

    Astone, P; Babusci, D; Bassan, M; Carelli, P; Cavallari, G; Coccia, E; Cosmelli, C; D'Antonio, S; Fafone, V; Fauth, A C; Federici, G; Giordano, G; Marini, A; Minenkov, Y; Modena, I; Modestino, G; Moleti, A; Pallottino, G V; Pizzella, G; Quintieri, L; Rocchi, A; Ronga, F; Terenzi, R; Torrioli, G; Visco, M

    2003-09-12

    Resonant gravitational wave detectors with an observation bandwidth of tens of hertz are a reality: the antenna Explorer, operated at CERN by the ROG Collaboration, has been upgraded with a new readout. In this new configuration, it exhibits an unprecedented useful bandwidth: in over 55 Hz about its center operating frequency of 919 Hz the spectral sensitivity is better than 10(-20) Hz(-1/2). We describe the detector and its sensitivity and discuss the foreseeable upgrades to even larger bandwidths.

  17. Validity of leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis

    PubMed Central

    Huang, Le; You, Yong-ke; Zhu, Tracy Y; Zheng, Li-zhen; Huang, Xiao-ru; Chen, Hai-yong; Yao, Dong; Lan, Hui-yao; Qin, Ling

    2016-01-01

    This study aimed to evaluate the validation of the leptin receptor-deficient mice model for secondary osteoporosis associated with type 2 diabetes mellitus (T2DM) at bone micro-architectural level. Thirty three 36-week old male mice were divided into four groups: normal control (db/m) (n = 7), leptin receptor-deficient T2DM (db/db) (n = 8), human C-reactive protein (CRP) transgenic normal control (crp/db/m) (n = 7), and human CRP transgenic T2DM (crp/db/db) (n = 11). Lumber vertebrae (L5) and bilateral lower limbs were scanned by micro-CT to analyze trabecular and cortical bone quality. Right femora were used for three-point bending to analyze the mechanical properties. Trabecular bone quality at L5 was better in db/db or crp/db/db group in terms of bone mineral density (BMD), bone volume fraction, connectivity density, trabecular number and separation (all p < 0.05). However the indices measured at proximal tibia showed comparable trabecular BMD and microarchitecture among the four groups. Femur length in crp/db/db group was significantly shorter than db/m group (p < 0.05) and cortices were thinner in db/db and crp/db/db groups (p > 0.05). Maximum loading and energy yield in mechanical test were similar among groups while the elastic modulus in db/db and crp/db/db significantly lower than db/m. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with T2DM. PMID:27283954

  18. Validity of leptin receptor-deficiency (db/db) type 2 diabetes mellitus mice as a model of secondary osteoporosis

    NASA Astrophysics Data System (ADS)

    Huang, Le; You, Yong-Ke; Zhu, Tracy Y.; Zheng, Li-Zhen; Huang, Xiao-Ru; Chen, Hai-Yong; Yao, Dong; Lan, Hui-Yao; Qin, Ling

    2016-06-01

    This study aimed to evaluate the validation of the leptin receptor-deficient mice model for secondary osteoporosis associated with type 2 diabetes mellitus (T2DM) at bone micro-architectural level. Thirty three 36-week old male mice were divided into four groups: normal control (db/m) (n = 7), leptin receptor-deficient T2DM (db/db) (n = 8), human C-reactive protein (CRP) transgenic normal control (crp/db/m) (n = 7), and human CRP transgenic T2DM (crp/db/db) (n = 11). Lumber vertebrae (L5) and bilateral lower limbs were scanned by micro-CT to analyze trabecular and cortical bone quality. Right femora were used for three-point bending to analyze the mechanical properties. Trabecular bone quality at L5 was better in db/db or crp/db/db group in terms of bone mineral density (BMD), bone volume fraction, connectivity density, trabecular number and separation (all p < 0.05). However the indices measured at proximal tibia showed comparable trabecular BMD and microarchitecture among the four groups. Femur length in crp/db/db group was significantly shorter than db/m group (p < 0.05) and cortices were thinner in db/db and crp/db/db groups (p > 0.05). Maximum loading and energy yield in mechanical test were similar among groups while the elastic modulus in db/db and crp/db/db significantly lower than db/m. The leptin-receptor mice is not a proper model for secondary osteoporosis associated with T2DM.

  19. Minimum cost maximum flow algorithm for upstream bandwidth allocation in OFDMA passive optical networks

    NASA Astrophysics Data System (ADS)

    Wu, Yating; Kuang, Bin; Wang, Tao; Zhang, Qianwu; Wang, Min

    2015-12-01

    This paper presents a minimum cost maximum flow (MCMF) based upstream bandwidth allocation algorithm, which supports differentiated QoS for orthogonal frequency division multiple access passive optical networks (OFDMA-PONs). We define a utility function as the metric to characterize the satisfaction degree of an ONU on the obtained bandwidth. The bandwidth allocation problem is then formulated as maximizing the sum of the weighted total utility functions of all ONUs. By constructing a flow network graph, we obtain the optimized bandwidth allocation using the MCMF algorithm. Simulation results show that the proposed scheme improves the performance in terms of mean packet delay, packet loss ratio and throughput.

  20. The transmission of symmetric 40 Gb/s TWDM-based NG-PON2 utilizing delay interferometer (DI) for RSOA bandwidth enhancement

    NASA Astrophysics Data System (ADS)

    Bindhaiq, Salem; Zulkifli, Nadiatulhuda; Supa'at, AbuSahmah M.

    2016-07-01

    Time and wavelength-division multiplexed passive optical network (TWDM-PON) has been finally selected as the pragmatic solution for the next-generation passive optical network stage 2 (NG-PON2). In this paper, we propose a symmetric 40 Gb/s TWDM-PON system with low cost reflective semiconductor optical amplifier (RSOA) for both downstream and upstream directions. A single bi-pass delay interferometer (DI), deployed in the optical line terminal (OLT), is used to enhance the poor performance of the RSOA with respect to the low bandwidth induced by laser chirp. With the help of the 40 GHz free spectrum range (FSR) DI, we show a successful transmission of the proposed work through simulation study where an aggregate capacity of 40 Gb/s is transported over 40 km transmission distance with 32 splits. The TWDM-PON system at BER of 10-6 has shown a minimum receiver sensitivity of -22.78 dBm and -22.71 dBm for both downstream and upstream, respectively with maximum power penalty of 2 dB for downstream channel and 2.39 dB for upstream channel.

  1. Chlorogenic Acid Improves Late Diabetes through Adiponectin Receptor Signaling Pathways in db/db Mice

    PubMed Central

    Jin, Shasha; Chang, Cuiqing; Zhang, Lantao; Liu, Yang; Huang, Xianren; Chen, Zhimin

    2015-01-01

    The aim of this study was to examine the effects of chlorogenic acid (CGA) on glucose and lipid metabolism in late diabetic db/db mice, as well as on adiponectin receptors and their signaling molecules, to provide evidence for CGA in the prevention of type 2 diabetes. We randomly divided 16 female db/db mice into db/db-CGA and db/db-control (CON) groups equally; db/m mice were used as control mice. The mice in both the db/db-CGA and db/m-CGA groups were administered 80 mg/kg/d CGA by lavage for 12 weeks, whereas the mice in both CON groups were given equal volumes of phosphate-buffered saline (PBS) by lavage. At the end of the intervention, we assessed body fat and the parameters of glucose and lipid metabolism in the plasma, liver and skeletal muscle tissues as well as the levels of aldose reductase (AR) and transforming growth factor-β1 (TGF-β1) in the kidneys and measured adiponectin receptors and the protein expression of their signaling molecules in liver and muscle tissues. After 12 weeks of intervention, compared with the db/db-CON group, the percentage of body fat, fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c) in the db/db-CGA group were all significantly decreased; TGF-β1 protein expression and AR activity in the kidney were both decreased; and the adiponectin level in visceral adipose was increased. The protein expression of adiponectin receptors (ADPNRs), the phosphorylation of AMP-activated protein kinase (AMPK) in the liver and muscle, and the mRNA and protein levels of peroxisome proliferator-activated receptor alpha (PPAR-α) in the liver were all significantly greater. CGA could lower the levels of fasting plasma glucose and HbA1c during late diabetes and improve kidney fibrosis to some extent through the modulation of adiponectin receptor signaling pathways in db/db mice. PMID:25849026

  2. MiR-138 promotes smooth muscle cells proliferation and migration in db/db mice through down-regulation of SIRT1

    SciTech Connect

    Xu, Juan; Li, Li; Yun, Hui-fang; Han, Ye-shan

    2015-08-07

    Background: Diabetic vascular smooth muscle cells (VSMCs) exhibit significantly increased rates of proliferation and migration, which was the most common pathological change in atherosclerosis. In addition, the study about the role for miRNAs in the regulation of VSMC proliferation is just beginning to emerge and additional miRNAs involved in VSMC proliferation modulation should be identified. Methods: The expression of miR-138 and SIRT1 were examined in SMCs separated from db/db mice and in SMC lines C-12511 exposed to high glucose with qRT-PCR and western blot. The regulation of miR-138 on the expression of SMCs was detected with luciferase report assay. VSMCs proliferation and migration assays were performed to examine the effect of miR-138 inhibitor on VSMCs proliferation and migration. Results: We discovered that higher mRNA level of miR-138 and reduced expression of SIRT1 were observed in SMCs separated from db/db mice and in SMC lines C-12511. Moreover, luciferase report assay showed that the activity of SIRT1 3′-UTR was highly increased by miR-138 inhibitor and reduced by miR-138 mimic. In addition, we examined that the up-regulation of NF-κB induced by high glucose in SMCs was reversed by resveratrol and miR-138 inhibitor. MTT and migration assays showed that miR-138 inhibitor attenuated the proliferation and migration of smooth muscle cells. Conclusion: In this study, we revealed that miR-138 might promote proliferation and migration of SMC in db/db mice through suppressing the expression of SIRT1. - Highlights: • Higher mRNA level of miR-138 was observed in SMCs from db/db mice. • The mRNA and protein level of SIRT1 in SMCs from db/db mice were greatly reduced. • miR-138 could regulate the expression of SIRT1 in SMCs. • SIRT1 overexpression reversed the up-regulation of acetylized p65 and NF-κB induced by high glucose. • MiR-138 inhibitor reversed VSMCs proliferation and migration induced by high glucose.

  3. Exendin-4 improves resistance to Listeria monocytogenes infection in diabetic db/db mice

    PubMed Central

    Liu, Hsien Yueh; Chung, Chih-Yao; Yang, Wen-Chin; Liang, Chih-Lung; Wang, Chi-Young; Chang, Chih-Yu

    2012-01-01

    The incidence of diabetes mellitus is increasing among companion animals. This disease has similar characteristics in both humans and animals. Diabetes is frequently identified as an independent risk factor for infections associated with increased mortality. In the present study, homozygous diabetic (db/db) mice were infected with Listeria (L.) monocytogenes and then treated with the anti-diabetic drug exendin-4, a glucagon-like peptide 1 analogue. In aged db/db mice, decreased CD11b+ macrophage populations with higher lipid content and lower phagocytic activity were observed. Exendin-4 lowered high lipid levels and enhanced phagocytosis in macrophages from db/db mice infected with L. monocytogenes. Exendin-4 also ameliorated obesity and hyperglycemia, and improved ex vivo bacteria clearance by macrophages in the animals. Liver histology examined during L. monocytogenes infection indicated that abscess formation was much milder in exendin-4-treated db/db mice than in the control animals. Moreover, mechanistic studies demonstrated that expression of ATP binding cassette transporter 1, a sterol transporter, was higher in macrophages isolated from the exendin-4-treated db/db mice. Overall, our results suggest that exendin-4 decreases the risk of infection in diabetic animals by modifying the interaction between intracellular lipids and phagocytic macrophages. PMID:23000581

  4. Bandwidth enhancement of electromagnetic coupled nonuniform H-shaped microstrip patch antenna for higher band of Wi-MAX applications

    NASA Astrophysics Data System (ADS)

    Bhardwaj, Dheeraj; Gulati, Gitansh; Saraswat, Srishti; Sharma, Komal

    2016-03-01

    The bandwidth enhancement of a stacked non-uniform electromagnetically coupled H-shaped Microstrip Antenna (SNHMA) with tapered edges is analyzed and simulated using the IE3D simulator. The proposed antenna prototype is drafted on FR-4 material and stacked further with an air discontinuity of 0.3 mm to the next layer. The various parameters optimized to achieve the best performance from the modified SNHMA primarily include a)length b)width of the patch c)air gap thickness. The redesigned antenna serves at two distinct frequencies with an elevated bandwidth of 30.85 % at the central frequency 5.762 GHz, approximately four times the bandwidth of the standard patch having the same dimensions. The simulated radiation patterns (E-plane and H-plane) are exhibited within the range of frequencies where the broadband response is observed. The specifications of the proposed structure make it promising for the higher band of Wi-MAX applications.

  5. Anti-Diabetic Effect of Aster sphathulifolius in C57BL/KsJ-db/db Mice.

    PubMed

    Yin, Xingfu; Huang, Yuhua; Jung, Da-Woon; Chung, Hee Chul; Choung, Se Young; Shim, Jae-Hoon; Kang, Il-Jun

    2015-09-01

    In this study, we investigated the anti-diabetic effect of Aster sphathulifolius (AS) extract in C57BL/KsJ-db/db mice. The db/db mice were orally administered with AS 50% ethanol extract at concentrations of 50, 100, and 200 mg/kg/day (db/db-AS50, db/db-AS100, and db/db-AS200, respectively) for 10 weeks. Food and water intake, fasting blood glucose concentrations, blood glycosylated hemoglobin levels, and plasma insulin levels were significantly lower in the db/db-AS200 group than in the vehicle-treated db/db group; whereas glucose tolerance was significantly improved in the db/db-AS200 group. Moreover, AS dose dependently increased both insulin receptor substrate 1 and glucose transporter type 4 expression in skeletal muscle, significantly increased glucokinase expression, and decreased glucose 6-phosphatase and phosphoenolpyruvate carboxykinase expressions in the liver. The expressions of transcription factors, such as sterol-regulatory element-binding protein, peroxisome proliferator-activated receptor γ, and adipocyte protein 2, were upregulated in adipose tissue. Furthermore, immunohistochemical analysis showed that AS upregulated insulin production by increasing pancreatic β-cell mass. In summary, AS extract normalized hyperglycemia by multiple mechanisms: inhibition of glyconeogenesis, acceleration of glucose metabolism and lipid metabolism, and increase of glucose uptake. Using in vivo assays, this study has shown the potential of AS as a medicinal food and suggests the efficacy of AS for the use of prevention of diabetes.

  6. Model Based Bandwidth Scavenging for Device Coexistence in Wireless LANs

    NASA Astrophysics Data System (ADS)

    Plummer, Anthony; Taghizadeh, Mahmoud; Biswas, Subir

    Dynamic Spectrum Access in a Wireless LAN can enable a set of secondary users' devices to access unused spectrum, or whitespace, which is found between the transmissions of a set of primary users' devices. The primary design objectives for an efficient secondary user access strategy are to be able to "scavenge" spatio-temporally fragmented bandwidth while limiting the amount of interference caused to the primary users. In this paper, we propose a secondary user access strategy which is based on measurement and modeling of the whitespace as perceived by the secondary users in a WLAN. A secondary user continually monitors and models its surrounding whitespace, and then attempts to access the available spectrum so that the effective secondary throughput is maximized while the resulting interference to the primary users is limited to a pre-defined bound. We first develop analytical expressions for the secondary throughput and primary interference, and then perform ns2 based simulation experiments to validate the effectiveness of the proposed access strategy, and evaluate its performance numerically using the developed expressions.

  7. Gain-Bandwidth Product Optimization of Heterostructure Avalanche Photodiodes

    NASA Astrophysics Data System (ADS)

    Kwon, Oh-Hyun; Hayat, Majeed M.; Campbell, Joe C.; Saleh, Bahaa E. A.; Teich, Malvin C.

    2005-05-01

    A generalized history-dependent recurrence theory for the time-response analysis is derived for avalanche photodiodes with multilayer, heterojunction multiplication regions. The heterojunction multiplication region considered consists of two layers: a high-bandgap Al_0.6 Ga_0.4 As energy-buildup layer, which serves to heat up the primary electrons, and a GaAs layer, which serves as the primary avalanching layer. The model is used to optimize the gain-bandwidth product (GBP) by appropriate selection of the width of the energy-buildup layer for a given width of the avalanching layer. The enhanced GBP is a direct consequence of the heating of primary electrons in the energy-buildup layer, which results in a reduced first dead space for the carriers that are injected into the avalanche-active GaAs layer. This effect is akin to the initial-energy effect previously shown to enhance the excess-noise factor characteristics in thin avalanche photodiodes (APDs). Calculations show that the GBP optimization is insensitive to the operational gain and the optimized APD also minimizes the excess-noise factor.

  8. Social value of high bandwidth networks: creative performance and education.

    PubMed

    Mansell, Robin; Foresta, Don

    2016-03-01

    This paper considers limitations of existing network technologies for distributed theatrical performance in the creative arts and for symmetrical real-time interaction in online learning environments. It examines the experience of a multidisciplinary research consortium that aimed to introduce a solution to latency and other network problems experienced by users in these sectors. The solution builds on the Multicast protocol, Access Grid, an environment supported by very high bandwidth networks. The solution is intended to offer high-quality image and sound, interaction with other network platforms, maximum user control of multipoint transmissions, and open programming tools that are flexible and modifiable for specific uses. A case study is presented drawing upon an extended period of participant observation by the authors. This provides a basis for an examination of the challenges of promoting technological innovation in a multidisciplinary project. We highlight the kinds of technical advances and cultural and organizational changes that would be required to meet demanding quality standards, the way a research consortium planned to engage in experimentation and learning, and factors making it difficult to achieve an open platform that is responsive to the needs of users in the creative arts and education sectors.

  9. One "shape" fits all: the orientation bandwidth of contour integration.

    PubMed

    Hansen, Bruce C; May, Keith A; Hess, Robert F

    2014-11-18

    The ability of human participants to integrate fragmented stimulus elements into perceived coherent contours (amidst a field of distracter elements) has been intensively studied across a large number of contour element parameters, ranging from luminance contrast and chromaticity to motion and stereo. The evidence suggests that contour integration performance depends on the low-level Fourier properties of the stimuli. Thus, to understand contour integration, it would be advantageous to understand the properties of the low-level filters that the visual system uses to process contour stimuli. We addressed this issue by examining the role of stimulus element orientation bandwidth in contour integration, a previously unexplored area. We carried out three psychophysical experiments, and then simulated all of the experiments using a recently developed two-stage filter-overlap model whereby the contour grouping occurs by virtue of the overlap between the filter responses to different elements. The first stage of the model responds to the elements, while the second stage integrates the responses along the contour. We found that the first stage had to be fairly broadly tuned for orientation to account for our results. The model showed a very good fit to a large data set with relatively few free parameters, suggesting that this class of model may have an important role to play in helping us to better understand the mechanisms of contour integration.

  10. QoS routing via multiple paths using bandwidth reservation

    SciTech Connect

    Rao, N.S.V.; Batsell, S.G.

    1997-11-01

    The authors address the problem of computing a multipath, consisting of possibly overlapping paths, to transmit data from the source node s to the destination node d over a computer network while ensuring deterministic bounds on end-to-end delay or delivery rate. They consider two generic routing problems within the framework wherein bandwidth can be reserved, and guaranteed, once reserved, on various links of the communication network. The first problem requires that a message of finite length be transmitted from s to d within {tau} units of time. The second problem requires that a sequential message of r units be transmitted at a rate of {eta} such that maximum time difference between two units that are received out of order is no more than q. They propose a polynomial-time algorithm to the first problem based on an adaptation of the classical Ford-Fulkerson`s method. They present simulation results to illustrate the applicability of the proposed algorithm. They show the second problem to be NP-complete and propose a polynomial-time approximate solution.

  11. QoS routing via multiple paths using bandwidth reservation

    SciTech Connect

    Rao, N.S.V.; Batsell, S.G.

    1998-01-01

    The authors address the problem of computing a multipath, consisting of possibly overlapping paths, to transmit data from the source node s to the destination node d over a computer network while ensuring deterministic bounds on end-to-end delay or delivery rate.They consider two generic routing problems within the framework wherein bandwidth can be reserved, and guaranteed, once reserved, on various links of the communication network. The first problem requires that a message of finite length be transmitted from s to d within {tau} units of time. The second problem requires that a sequential message of r units be transmitted at a rate of {eta} such that maximum time difference between two units that are received out of order is no more than q. They propose a polynomial-time algorithm to the first problem based on an adaptation of the classical Ford-Fulkerson`s method. They present simulation results to illustrate the applicability of the proposed algorithm. They show the second problem to be NP-complete, and propose a polynomial-time approximately solution.

  12. High-bandwidth protein analysis using solid-state nanopores.

    PubMed

    Larkin, Joseph; Henley, Robert Y; Muthukumar, Murugappan; Rosenstein, Jacob K; Wanunu, Meni

    2014-02-01

    High-bandwidth measurements of the ion current through hafnium oxide and silicon nitride nanopores allow the analysis of sub-30 kD protein molecules with unprecedented time resolution and detection efficiency. Measured capture rates suggest that at moderate transmembrane bias values, a substantial fraction of protein translocation events are detected. Our dwell-time resolution of 2.5 μs enables translocation time distributions to be fit to a first-passage time distribution derived from a 1D diffusion-drift model. The fits yield drift velocities that scale linearly with voltage, consistent with an electrophoretic process. Further, protein diffusion constants (D) are lower than the bulk diffusion constants (D0) by a factor of ~50, and are voltage-independent in the regime tested. We reason that deviations of D from D0 are a result of confinement-driven pore/protein interactions, previously observed in porous systems. A straightforward Kramers model for this inhibited diffusion points to 9- to 12-kJ/mol interactions of the proteins with the nanopore. Reduction of μ and D are found to be material-dependent. Comparison of current-blockage levels of each protein yields volumetric information for the two proteins that is in good agreement with dynamic light scattering measurements. Finally, detection of a protein-protein complex is achieved.

  13. X-ray FEL with a meV bandwidth

    NASA Astrophysics Data System (ADS)

    Saldin, E. L.; Schneidmiller, E. A.; Shvyd'ko, Yu. V.; Yurkov, M. V.

    2001-08-01

    A new design for a single pass X-ray Self-Amplified Spontaneous Emission (SASE) FEL was proposed in [1] and named two-stage SASE FEL. The scheme consists of two undulators and an X-ray monochromator located between them. For the Angström wavelength range the monochromator could be realized using Bragg reflections from crystals. Proposed scheme of monochromator is illustrated for the 14.4 keV X-ray SASE FEL being developed in the framework of the TESLA linear collider project. The spectral bandwidth of the radiation from the two-stage SASE FEL (20 meV) is defined by the finite duration of the electron pulse. The shot-to-shot fluctuations of energy spectral density are dramatically reduced in comparison with the 100% fluctuations in a SASE FEL. The peak and average brilliance are by three orders of magnitude higher than the values which could be reached by a conventional X-ray SASE FEL.

  14. Review of single transient oscillographic recorders with gigahertz bandwidth

    SciTech Connect

    Campbell, D.E.

    1982-10-20

    In laser driven inertial confinement fusion research, at Livermore, we are diagnosing many phenomena that occur in a time frame that exceeds the capabilities of even the most advanced, present day oscillographic recording instruments. Many of the by-products of the interaction between the laser beam and fuel pellet are monitored to determine the specifics of the fusion process. By the use of appropriate detectors, we convert the information contained in the radiated by-products to electrical signals which are recorded on high bandwidth oscillographic recorders. Our present range of recording capabilities for one x-ray diagnostic measurement in use at Livermore is shown. A commonly used configuration consists of an XRD-31 x-ray detector connected to a direct access Tektronix R7912 transient digitizer using 1/2 in. diameter air dielectric coaxial cable. This configuration gives a system fwhm of approximately 335 ps. Our premier configuration, on the other hand, consists of an improved response detector and a French Thomson-CSF TSN-660 oscilloscope with a shorter length of coaxial cable (typically 20 feet). The system fwhm in this case is less than 120 ps which is our fastest oscillographic recording system at the present time.

  15. Social value of high bandwidth networks: creative performance and education.

    PubMed

    Mansell, Robin; Foresta, Don

    2016-03-01

    This paper considers limitations of existing network technologies for distributed theatrical performance in the creative arts and for symmetrical real-time interaction in online learning environments. It examines the experience of a multidisciplinary research consortium that aimed to introduce a solution to latency and other network problems experienced by users in these sectors. The solution builds on the Multicast protocol, Access Grid, an environment supported by very high bandwidth networks. The solution is intended to offer high-quality image and sound, interaction with other network platforms, maximum user control of multipoint transmissions, and open programming tools that are flexible and modifiable for specific uses. A case study is presented drawing upon an extended period of participant observation by the authors. This provides a basis for an examination of the challenges of promoting technological innovation in a multidisciplinary project. We highlight the kinds of technical advances and cultural and organizational changes that would be required to meet demanding quality standards, the way a research consortium planned to engage in experimentation and learning, and factors making it difficult to achieve an open platform that is responsive to the needs of users in the creative arts and education sectors. PMID:26809576

  16. The Development and Optimisation of High Bandwidth Bimorph Deformable Mirrors

    NASA Astrophysics Data System (ADS)

    Rowe, D.; Laycock, L.; Griffith, M.; Archer, N.

    Our first mirror designs were based on a standard bimorph construction and exhibited a resonant frequency of 1 kHz with a maximum stroke of ±5 μm. These devices were limited by the requirement to have a "dead space" between the inner active area and the mirror boundary. This was necessary to ensure that the requirements for both the stroke and the static boundary conditions at the edge of the mirror could be met simultaneously, but there was a significant penalty to pay in terms of bandwidth, which is inversely proportional to the square of the full mirror diameter. In a series of design iteration steps, we have created mounting arrangements that seek not only to reduce dead space, but also to improve ruggedness and temperature stability through the use of a repeatable and reliable assembly procedure. As a result, the most recently modeled mirrors display a resonance in excess of 5 kHz, combined with a maximum stroke in excess of ±10 μm. This has been achieved by virtually eliminating the "dead space" around the mirror. By careful thermal matching of the mirror and piezoelectric substrates, operation over a wide temperature range is possible. This paper will discuss the outcomes from the design study and present our initial experimental results for the most recently assembled mirror.

  17. Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice.

    PubMed

    Sun, Jing; Wang, Yongsen; Fu, Xueqi; Chen, Yingli; Wang, Deli; Li, Wannan; Xing, Shu; Li, Guodong

    2015-01-01

    Protein tyrosine phosphatase 1B (PTP1B) is an established therapeutic target for type 2 diabetes mellitus (T2DM) and obesity. The aim of this study was to investigate the inhibitory activity of Magnolia officinalis extract (ME) on PTP1B and its anti-T2DM effects. Inhibition assays and inhibition kinetics of ME were performed in vitro. 3T3-L1 adipocytes and C2C12 myotubes were stimulated with ME to explore its bioavailability in cell level. The in vivo studies were performed on db/db mice to probe its anti-T2DM effects. In the present study, ME inhibited PTP1B in a reversible competitive manner and displayed good selectivity against PTPs in vitro. Furthermore, ME enhanced tyrosine phosphorylation levels of cellular proteins, especially the insulin-induced tyrosine phosphorylations of insulin receptor β-subunit (IRβ) and ERK1/2 in a dose-dependent manner in stimulated 3T3-L1 adipocytes and C2C12 myotubes. Meanwhile, ME enhanced insulin-stimulated GLUT4 translocation. More importantly, there was a significant decrease in fasting plasma glucose level of db/db diabetic mice treated orally with 0.5 g/kg ME for 4 weeks. These findings indicated that improvement of insulin sensitivity and hypoglycemic effects of ME may be attributed to the inhibition of PTP1B. Thereby, we pioneered the inhibitory potential of ME targeted on PTP1B as anti-T2DM drug discovery. PMID:26064877

  18. The Gypsy Database (GyDB) of mobile genetic elements: release 2.0.

    PubMed

    Llorens, Carlos; Futami, Ricardo; Covelli, Laura; Domínguez-Escribá, Laura; Viu, Jose M; Tamarit, Daniel; Aguilar-Rodríguez, Jose; Vicente-Ripolles, Miguel; Fuster, Gonzalo; Bernet, Guillermo P; Maumus, Florian; Munoz-Pomer, Alfonso; Sempere, Jose M; Latorre, Amparo; Moya, Andres

    2011-01-01

    This article introduces the second release of the Gypsy Database of Mobile Genetic Elements (GyDB 2.0): a research project devoted to the evolutionary dynamics of viruses and transposable elements based on their phylogenetic classification (per lineage and protein domain). The Gypsy Database (GyDB) is a long-term project that is continuously progressing, and that owing to the high molecular diversity of mobile elements requires to be completed in several stages. GyDB 2.0 has been powered with a wiki to allow other researchers participate in the project. The current database stage and scope are long terminal repeats (LTR) retroelements and relatives. GyDB 2.0 is an update based on the analysis of Ty3/Gypsy, Retroviridae, Ty1/Copia and Bel/Pao LTR retroelements and the Caulimoviridae pararetroviruses of plants. Among other features, in terms of the aforementioned topics, this update adds: (i) a variety of descriptions and reviews distributed in multiple web pages; (ii) protein-based phylogenies, where phylogenetic levels are assigned to distinct classified elements; (iii) a collection of multiple alignments, lineage-specific hidden Markov models and consensus sequences, called GyDB collection; (iv) updated RefSeq databases and BLAST and HMM servers to facilitate sequence characterization of new LTR retroelement and caulimovirus queries; and (v) a bibliographic server. GyDB 2.0 is available at http://gydb.org.

  19. The Gypsy Database (GyDB) of mobile genetic elements: release 2.0.

    PubMed

    Llorens, Carlos; Futami, Ricardo; Covelli, Laura; Domínguez-Escribá, Laura; Viu, Jose M; Tamarit, Daniel; Aguilar-Rodríguez, Jose; Vicente-Ripolles, Miguel; Fuster, Gonzalo; Bernet, Guillermo P; Maumus, Florian; Munoz-Pomer, Alfonso; Sempere, Jose M; Latorre, Amparo; Moya, Andres

    2011-01-01

    This article introduces the second release of the Gypsy Database of Mobile Genetic Elements (GyDB 2.0): a research project devoted to the evolutionary dynamics of viruses and transposable elements based on their phylogenetic classification (per lineage and protein domain). The Gypsy Database (GyDB) is a long-term project that is continuously progressing, and that owing to the high molecular diversity of mobile elements requires to be completed in several stages. GyDB 2.0 has been powered with a wiki to allow other researchers participate in the project. The current database stage and scope are long terminal repeats (LTR) retroelements and relatives. GyDB 2.0 is an update based on the analysis of Ty3/Gypsy, Retroviridae, Ty1/Copia and Bel/Pao LTR retroelements and the Caulimoviridae pararetroviruses of plants. Among other features, in terms of the aforementioned topics, this update adds: (i) a variety of descriptions and reviews distributed in multiple web pages; (ii) protein-based phylogenies, where phylogenetic levels are assigned to distinct classified elements; (iii) a collection of multiple alignments, lineage-specific hidden Markov models and consensus sequences, called GyDB collection; (iv) updated RefSeq databases and BLAST and HMM servers to facilitate sequence characterization of new LTR retroelement and caulimovirus queries; and (v) a bibliographic server. GyDB 2.0 is available at http://gydb.org. PMID:21036865

  20. Facile synthesis of BaTiO3 nanotubes and their microwave absorption properties.

    PubMed

    Zhu, Yao-Feng; Zhang, Li; Natsuki, Toshiaki; Fu, Ya-Qin; Ni, Qing-Qing

    2012-04-01

    Uniform BaTiO(3) nanotubes were synthesized via a simple wet chemical route at low temperature (50 °C). The as-synthesized BaTiO(3) nanotubes were characterized using powder X-ray diffraction, field-emission scanning electron microscopy, transmission electron microscopy, Raman spectroscopy, and X-ray photoelectron spectroscopy. The results show that the BaTiO(3) nanotubes formed a cubic phase with an average diameter of ~10 nm and wall thickness of 3 nm at room temperature. The composition of the mixed solvent (ethanol and deionized water) was a key factor in the formation of these nanotubes; we discuss possible synthetic mechanisms. The microwave absorption properties of the BaTiO(3) nanotubes were studied at microwave frequencies between 0.5 and 15 GHz. The minimum reflection loss of the BaTiO(3) nanotubes/paraffin wax composite (BaTiO(3) nanotubes weight fraction = 70%) reached 21.8 dB (~99.99% absorption) at 15 GHz, and the frequency bandwidth less than -10 dB is from 13.3 to 15 GHz. The excellent absorption property of BaTiO(3) nanotubes at high frequency indicates that these nanotubes could be promising microwave-absorbing materials. PMID:22409350

  1. Comparative study of bandwidths in copper delafossites from x-ray emission spectroscopy

    NASA Astrophysics Data System (ADS)

    Shin, D.; Foord, J. S.; Payne, D. J.; Arnold, T.; Aston, D. J.; Egdell, R. G.; Godinho, K. G.; Scanlon, D. O.; Morgan, B. J.; Watson, G. W.; Mugnier, E.; Yaicle, C.; Rougier, A.; Colakerol, L.; Glans, P. A.; Piper, L. F. J.; Smith, K. E.

    2009-12-01

    The widths of the valence bands in the copper (I) delafossites CuGaO2 , CuInO2 , and CuScO2 have been measured by OK -shell x-ray emission spectroscopy and are compared with previous experimental work on CuAlO2 and CuCrO2 . In agreement with recent density-functional theory calculations it is found that the bandwidth decreases in the series CuAlO2>CuGaO2>CuInO2>CuScO2 . It is shown that states at the top of the valence band are of dominant Cu3dz2 atomic character but with significant mixing with O2p states.

  2. A hybrid OFDM-TDM architecture with decentralized dynamic bandwidth allocation for PONs.

    PubMed

    Cevik, Taner

    2013-01-01

    One of the major challenges of passive optical networks is to achieve a fair arbitration mechanism that will prevent possible collisions from occurring at the upstream channel when multiple users attempt to access the common fiber at the same time. Therefore, in this study we mainly focus on fair bandwidth allocation among users, and present a hybrid Orthogonal Frequency Division Multiplexed/Time Division Multiplexed architecture with a dynamic bandwidth allocation scheme that provides satisfying service qualities to the users depending on their varying bandwidth requirements. Unnecessary delays in centralized schemes occurring during bandwidth assignment stage are eliminated by utilizing a decentralized approach. Instead of sending bandwidth demands to the optical line terminal (OLT) which is the only competent authority, each optical network unit (ONU) runs the same bandwidth demand determination algorithm. ONUs inform each other via signaling channel about the status of their queues. This information is fed to the bandwidth determination algorithm which is run by each ONU in a distributed manner. Furthermore, Light Load Penalty, which is a phenomenon in optical communications, is mitigated by limiting the amount of bandwidth that an ONU can demand.

  3. Bandwidth Management in Universities in Zimbabwe: Towards a Responsible User Base through Effective Policy Implementation

    ERIC Educational Resources Information Center

    Chitanana, Lockias

    2012-01-01

    This research was undertaken to investigate the issue of how to maximise or make efficient use of bandwidth. In particular, the research sought to find out about what universities in Zimbabwe are doing to manage their bandwidth. It was, therefore, appropriate to survey a sample of five universities and to catalogue their experiences. Results show…

  4. Closed form expressions for computing the occupied bandwidth of PCM/PSK/PM signals

    NASA Technical Reports Server (NTRS)

    Nguyen, Tien M.

    1991-01-01

    This paper presents a computational technique to determine the occupied bandwidth for a class of PCM/PSK/PM signals. The signals considered here employ either a squarewave of sinewave subcarrier. Closed form expressions for the occupied bandwidth as a function of the subcarrier frequency-to-bit-rate ratio with modulation index as a parameter are derived using linear-fitting techniques.

  5. A Survey of Bandwidth Utilization: Case Study of Federal University of Technology Minna

    NASA Astrophysics Data System (ADS)

    Haq, A.; Bello Salau, H.; Aibinu, A. M.; Onwuka, E. N.

    2013-12-01

    The effective utilization of the limited scarce bandwidth resources allocated by a spectrum regulator usually the Nigerian Communications Commissions (NCC) in Nigeria universities is paramount in maximizing the usage of the expensive scarce bandwidth resources. A significant bandwidth allocation is needed in order to meet up with the challenges of the day and the task of networking, communicating and reaching the word in our universities. Therefore, bandwidth management becomes necessary and essential. This paper contributes in that direction by surveying the bandwidth utilization at Federal University of Technology Minna campus with the hope of proffering a general solution that can be adopted in Nigerian universities for effective bandwidth management. Also, factors that hindered the development of most Nigeria universities are also examined. The federal university of technology minna which is structured like all other universities in the country in terms of the bandwidth requirement was choosing as a case study for this research work. Furthermore, some policies which can be adopted in order to effectively manage the scarce bandwidth resources in Nigerian universities are also proposed.

  6. A Hybrid OFDM-TDM Architecture with Decentralized Dynamic Bandwidth Allocation for PONs

    PubMed Central

    Cevik, Taner

    2013-01-01

    One of the major challenges of passive optical networks is to achieve a fair arbitration mechanism that will prevent possible collisions from occurring at the upstream channel when multiple users attempt to access the common fiber at the same time. Therefore, in this study we mainly focus on fair bandwidth allocation among users, and present a hybrid Orthogonal Frequency Division Multiplexed/Time Division Multiplexed architecture with a dynamic bandwidth allocation scheme that provides satisfying service qualities to the users depending on their varying bandwidth requirements. Unnecessary delays in centralized schemes occurring during bandwidth assignment stage are eliminated by utilizing a decentralized approach. Instead of sending bandwidth demands to the optical line terminal (OLT) which is the only competent authority, each optical network unit (ONU) runs the same bandwidth demand determination algorithm. ONUs inform each other via signaling channel about the status of their queues. This information is fed to the bandwidth determination algorithm which is run by each ONU in a distributed manner. Furthermore, Light Load Penalty, which is a phenomenon in optical communications, is mitigated by limiting the amount of bandwidth that an ONU can demand. PMID:24194684

  7. Bandwidth-length trade-off figures of merit for electro-optic traveling wave modulators.

    PubMed

    Ibarra Fuste, Jose A; Santos Blanco, Maria C

    2013-05-01

    Closed-form expressions explicitly relating modulation bandwidth and active length in electro-optic traveling wave modulators are presented which fully account for skin-effect electrode loss and optical-electrical wave velocities mismatch. Four operative margins have been identified where the bandwidth-length trade-off figure of merit takes simple forms.

  8. Effects of large laser bandwidth on stimulated Raman scattering instability in underdense plasma

    SciTech Connect

    Zhao, Yao; Yu, Lu-Le; Zheng, Jun; Weng, Su-Ming; Ren, Chuang; Liu, Chuan-Sheng; Sheng, Zheng-Ming E-mail: zhengming.sheng@strath.ac.uk

    2015-05-15

    The effects of laser bandwidth on stimulated Raman scattering (SRS) instability in underdense plasma are studied by particle-in-cell simulations. In the simulations, sinusoidal frequency modulation of the incident laser pulse is used. By changing the size of bandwidth, it is shown that the linear growth of SRS can be suppressed considerably, provided the laser bandwidth is much larger than the SRS linear growth rate. Simulations also show that by choosing the proper frequency modulation parameters or decreasing the linear growth rate of SRS, the inhibitory effects become more obvious. The plasma electron temperature tends to weaken the bandwidth effects especially when it is over a keV level. The laser bandwidth can only increase the time duration for linear growth but cannot diminish the instability completely.

  9. Enhanced spectral efficiency using bandwidth switchable SAW filtering for mobile satellite communications systems

    NASA Technical Reports Server (NTRS)

    Peach, Robert; Malarky, Alastair

    1990-01-01

    Currently proposed mobile satellite communications systems require a high degree of flexibility in assignment of spectral capacity to different geographic locations. Conventionally this results in poor spectral efficiency which may be overcome by the use of bandwidth switchable filtering. Surface acoustic wave (SAW) technology makes it possible to provide banks of filters whose responses may be contiguously combined to form variable bandwidth filters with constant amplitude and phase responses across the entire band. The high selectivity possible with SAW filters, combined with the variable bandwidth capability, makes it possible to achieve spectral efficiencies over the allocated bandwidths of greater than 90 percent, while retaining full system flexibility. Bandwidth switchable SAW filtering (BSSF) achieves these gains with a negligible increase in hardware complexity.

  10. Effect of bandwidth knowledge of results on the learning of a grip force control task.

    PubMed

    Ugrinowitsch, Herbert; Ugrinowitsch, Alessandra Aguilar Coca; Benda, Rodolfo Novellino; Tertuliano, Ivan Wallan

    2010-12-01

    An experiment was conducted to investigate the persistence of the effect of "bandwidth knowledge of results (KR)" manipulated during the learning phase of performing a manual force-control task. The experiment consisted of two phases, an acquisition phase with the goal of maintaining 60% maximum force in 30 trials, and a second phase with the objective of maintaining 40% of maximum force in 20 further trials. There were four bandwidths of KR: when performance error exceeded 5, 10, or 15% of the target, and a control group (0% bandwidth). Analysis showed that 5, 10, and 15% bandwidth led to better performance than 0% bandwidth KR at the beginning of the second phase and persisted during the extended trials.

  11. 1.25-3.125 Gb/s per user PON with RSOA as phase modulator for statistical wavelength ONU

    NASA Astrophysics Data System (ADS)

    Chu, Guang Yong; Polo, Victor; Lerín, Adolfo; Tabares, Jeison; Cano, Iván N.; Prat, Josep

    2015-12-01

    We report a new scheme to support, cost efficiently, ultra-dense wavelength division multiplexing (UDWDM) for optical access networks. As validating experiment, we apply phase modulation of a reflective semiconductor optical amplifier (RSOA) at the ONU with a single DFB, and simplified coherent receiver at OLT for upstream. We extend the limited 3-dB modulation bandwidth of available uncooled To-can packaged RSOA (~400 MHz) and operate it at 3.125 Gb/s with the optimal performance for phase modulation using small and large signal measurement characteristics. The optimal condition is selected at input power of 0 dBm, with 70 mA bias condition. The sensitivities at 3.125 Gb/s (at BER=10-3) for heterodyne and intradyne detection reach -34.3 dBm and -38.8 dBm, respectively.

  12. Measuring complex pulses with time-bandwidth products exceeding 65,000 using multiple-delay crossed-beam spectral interferometry

    NASA Astrophysics Data System (ADS)

    Cohen, Jacob; Bowlan, Pamela; Chauhan, Vikrant; Vaughan, Peter; Trebino, Rick

    2011-03-01

    We measure the complete electric field of extremely complex ultrafast waveforms using the simple linear-optical, interferometric pulse-measurement technique, MUD TADPOLE. In its scanning variation, we measured waveforms with time-bandwidth products exceeding 65,000 with ~40 fs temporal resolution over a temporal range of ~3.5ns. In the single-shot variation we measured complex waveforms time-bandwidth products exceeding 65,000. The approach is general and could allow the measurement of arbitrary optical waveforms.

  13. Fixed tile rate codec for bandwidth saving in video processors

    NASA Astrophysics Data System (ADS)

    Lachine, Vladimir; Dinh, Chon-Tam Le; Le, Dinh Kha; Wong, Jeffrey

    2014-02-01

    The paper presents an image compression circuit for bandwidth saving in video display processors. This is intra frame tile based compression algorithm offering visually lossless quality for compression rates between 1.5 and 2.5. RGB and YCbCr (4:4:4, 4:2:2 and 4:2:0) video formats are supported for 8/10 bits video signals. The Band Width Compressor (BWC) consists of Lossless Compressor (LC) and Quantization Compressor (QC) that generate output bit streams for tiles of pixels. Size of output bit stream generated for a tile by the LC may be less or greater than a required size of output memory block. The QC generates bit stream that always fits output memory block of the required size. The output bit stream generated by the LC is transmitted if its size is less than the required size of the output memory block. Otherwise, the output bit stream generated by the QC is transmitted. The LC works on pixel basis. A difference between original and predicted pixel's values for each pixel of a tile is encoded as prefix and suffix. The prefix is encoded by means of variable length code, and suffix is encoded as is. The QC divides a tile of pixels on a set of blocks and quantizes pixels of each block independently of the other blocks. The number of quantization bits for all pixels of a block depends on standard deviation calculated over the block. A difference between pixel's value and average value over the block is quantized and transmitted.

  14. Broad-Bandwidth FPGA-Based Digital Polyphase Spectrometer

    NASA Technical Reports Server (NTRS)

    Jamot, Robert F.; Monroe, Ryan M.

    2012-01-01

    With present concern for ecological sustainability ever increasing, it is desirable to model the composition of Earth s upper atmosphere accurately with regards to certain helpful and harmful chemicals, such as greenhouse gases and ozone. The microwave limb sounder (MLS) is an instrument designed to map the global day-to-day concentrations of key atmospheric constituents continuously. One important component in MLS is the spectrometer, which processes the raw data provided by the receivers into frequency-domain information that cannot only be transmitted more efficiently, but also processed directly once received. The present-generation spectrometer is fully analog. The goal is to include a fully digital spectrometer in the next-generation sensor. In a digital spectrometer, incoming analog data must be converted into a digital format, processed through a Fourier transform, and finally accumulated to reduce the impact of input noise. While the final design will be placed on an application specific integrated circuit (ASIC), the building of these chips is prohibitively expensive. To that end, this design was constructed on a field-programmable gate array (FPGA). A family of state-of-the-art digital Fourier transform spectrometers has been developed, with a combination of high bandwidth and fine resolution. Analog signals consisting of radiation emitted by constituents in planetary atmospheres or galactic sources are downconverted and subsequently digitized by a pair of interleaved analog-to-digital converters (ADCs). This 6-Gsps (gigasample per second) digital representation of the analog signal is then processed through an FPGA-based streaming fast Fourier transform (FFT). Digital spectrometers have many advantages over previously used analog spectrometers, especially in terms of accuracy and resolution, both of which are particularly important for the type of scientific questions to be addressed with next-generation radiometers.

  15. Enhanced Dielectric Properties and High-Temperature Microwave Absorption Performance of Zn-Doped Al2O3 Ceramic

    NASA Astrophysics Data System (ADS)

    Wang, Yuan; Luo, Fa; Wei, Ping; Zhou, Wancheng; Zhu, Dongmei

    2015-07-01

    To improve the dielectric and microwave absorption properties of Al2O3 ceramic, Zn-doped Al2O3 ceramic was prepared by conventional ceramic processing. X-ray diffraction analysis confirmed that Zn atoms successfully entered the Al2O3 ceramic lattice and occupied Al sites. The complex permittivity increased with increasing Zn concentration, which is mainly attributed to the increase in charged vacancy defects and densification of the Al2O3 ceramic. In addition, the temperature-dependent complex permittivity of 3% Zn-doped Al2O3 ceramic was determined in the temperature range from 298 K to 873 K. Both the real and imaginary parts of the complex permittivity increased monotonically with increasing temperature, which can be ascribed to the shortened relaxation time and increasing electrical conductivity. The increased complex permittivity leads to a great improvement in microwave absorption. In particular, when the temperature is up to 873 K, the 3% Zn-doped Al2O3 ceramic exhibited the best absorption performance with a maximum peak (-12.1 dB) and broad effective absorption bandwidth (reflection loss less than -10 dB from 9.3 GHz to 12.3 GHz). These results reveal that Zn-doped Al2O3 ceramic is a promising candidate for use as a kind of high-temperature microwave absorption material.

  16. 2 µm ultrafast fiber laser modelocked by mechanically exfoliated Sb2Te3

    NASA Astrophysics Data System (ADS)

    Tarka, Jan; Boguslawski, Jakub; Zybala, Rafał; Kowalczyk, Maciej; Sobon, Grzegorz; Sotor, Jaroslaw

    2016-03-01

    We demonstrate the usage of a saturable absorber material - antimony telluride (Sb2Te3) for efficient mode-locking of a Thulium-doped fiber laser. The Sb2Te3 layers were obtained by mechanical exfoliation and transferred onto the fiber ferrule. The all-fiber laser was capable of generating optical solitons with the full width at half-maximum of 4.5 nm centered at 1945 nm, with 39.5 MHz repetition rate and more than 60 dB signal to noise ratio. The pulse energy of the generated 890 fs pulses was at the level of 30 pJ. Our experiment showed that Sb2Te3 saturable absorbers are suitable for the operation in 2 μm bandwidth.

  17. Dietary Wolfberry Ameliorates Retinal Structure Abnormalities in db/db Mice at the Early Stage of Diabetes

    PubMed Central

    Tang, Ling; Zhang, Yunong; Jiang, Yu; Willard, Lloyd; Ortiz, Edlin; Wark, Logan; Medeiros, Denis; Lin, Dingbo

    2011-01-01

    Hyperglycemia-linked oxidative stress and/or consequent endoplasmic reticulum stress are the causative factors of pathogenesis of diabetic retinopathy. Dietary bioactive components which mitigate oxidative stress may serve as potential chemopreventative agents to prevent or slow down the disease progression. Wolfberry is a traditional Asian fruit consumed for years to prevent aging eye diseases in Asian countries. Here we report that dietary wolfberry ameliorated mouse retinal abnormality at the early stage of type 2 diabetes in db/db mice. Male mice at 6 weeks of age were fed the control diet with or without 1 % (kCal) wolfberry for 8 weeks. Dietary wolfberry restored the thickness of the whole retina, in particular the inner nuclear layer and photoreceptor layer, and the integrity of retinal pigment epithelia (RPE), and the ganglion cell number in db/db mice. Western blotting of whole retinal cell lysates revealed that addition of wolfberry lowered expression of endoplasmic reticulum (ER) stress biomarkers BiP, PERK, ATF6, and caspase-12; and restored AMPK, thioredoxin, Mn SOD, and FOXO3α activities. To determine if our observations were due to the high contents of zeaxanthin and lutein in wolfberry additional studies using these carotenoids were conducted. Using the human adult diploid RPE cell line ARPE-19 we demonstrated that both zeaxanthin and lutein could mimic wolfberry preventive effect on activation of AMPK, thioredoxin, Mn SOD, FOXO3α activities, normalize cellular reactive oxygen species, and attenuate ER stress in ARPE-19 cells exposed to a high glucose challenge. The zeaxanthin preventive effect was abolished by siRNA knockdown of AMPKα. These results suggested that AMPK activation appeared to play a key role in upregulated expression of thioredoxin and Mn SOD, and mitigation of cellular oxidative stress and/or ER stress by wolfberry and zeaxanthin and/or lutein. Taken together, dietary wolfberry on retinal protection in diabetic mice is, at least

  18. SOLV-DB: Solvents Data

    DOE Data Explorer

    SOLV-DB provides a specialized mix of information on commercially available solvents. The development of the database was funded under the Strategic Environmental Research and Development Program (SERDP) with funds from EPA and DOE's Office of Industrial Technologies in EE. The information includes: • Health and safety considerations involved in choosing and using solvents • Chemical and physical data affecting the suitability of a particular solvent for a wide range of potential applications • Regulatory responsibilities, including exposure and effluent limits, hazard classification status with respect to several key statutes, and selected reporting requirements • Environmental fate data, to indicate whether a solvent is likely to break down or persist in air or water, and what types of waste treatment techniques may apply to it • CAS numbers (from Chemical Abstracts Service) and Sax Numbers (from Sax, et.al., Dangerous Properties of Industrial Materials) Supplier Information See help information at http://solvdb.ncms.org/welcome.htm (Specialized Interface)

  19. Accelerating Scientific Analysis with SciDB

    NASA Astrophysics Data System (ADS)

    Gerhardt, L.; Faham, C. H.; Yao, Y.

    2015-12-01

    SciDB is an open-source analytical database for scalable complex analytics on very large array or multi-structured data from a variety of sources, programmable from Python and R. It runs on HPC, commodity hardware grids, or in a cloud and can manage and analyze terabytes of array-structured data and do complex analytics in-database. We present an overall description of the SciDB framework and describe its implementation at NERSC at Lawrence Berkeley National Laboratory. A case study using SciDB to analyze data from the LUX dark matter detector is described and future plans for a large SciDB array at NERSC are described.

  20. Gastric carcinogenesis by N-Methyl-N-nitrosourea is enhanced in db/db diabetic mice.

    PubMed

    Yoshizawa, Nao; Yamaguchi, Hirokazu; Yamamoto, Masami; Shimizu, Nobuyuki; Furihata, Chie; Tatematsu, Masae; Seto, Yasuyuki; Kaminishi, Michio

    2009-07-01

    In 2005, a Japanese epidemiological study showed that increase in plasma glucose levels is a risk factor for gastric cancer. However, no animal model has hitherto shown any association between diabetes mellitus and neoplasia in the stomach. Diabetic (db/db) mice have obese and diabetic phenotypes, including hyperglycemia, because of disruption of the leptin receptor. In the present study, effects of hyperglycemia and/or hyperinsulinemia on the development of proliferative lesions were therefore examined in db/db mice given N-methyl-N-nitrosourea (MNU). A total of 120 mice were assigned to four groups: Group A, 40 db/db mice with MNU; Group B, 40 + /db mice with MNU; Group C, 30 misty (wild-type) mice with MNU; Group D, 10 db/db mice without MNU. MNU was given at 60 ppm in drinking water for 20 weeks. Subgroups of animals were sacrificed at weeks 21 and 30 and blood samples were collected to measure glucose, insulin, leptin, and adiponectin concentrations. The removed stomachs were fixed in formalin, and embedded in paraffin for histological examination and immunohistochemistry. At week 30 in Groups A, B, C and D, hyperplasia was observed in 100, 79, 57, and 0%, and dysplasia in 91, 43, 71, and 0%, respectively. Adenocarcinomas and pepsinogen-altered pyloric glands (PAPG), putative preneoplastic lesions, were observed only in Group A, at an incidence of 45%. The serum levels of insulin and leptin were also elevated in Group A. Gastric carcinogenesis by MNU was enhanced in db/db mice, possibly in association with hyperinsulinemia and hyperleptinemia. PMID:19432903

  1. Shengmai San Ameliorates Myocardial Dysfunction and Fibrosis in Diabetic db/db Mice

    PubMed Central

    Cao, Tong-Tong; Tian, Jing; Chen, Hui-hua; Lu, Rong

    2016-01-01

    In this study, we mainly investigated the effects of Shengmai San (SMS) on diabetic cardiomyopathy (DCM) in db/db mice. The db/db mice were randomly divided into model group and SMS group, while C57BLKS/J inbred mice were used as controls. After 24-week treatment, blood glucose, body weight, and heart weight were determined. Hemodynamic changes in the left ventricle were measured using catheterization. The myocardial structure and subcellular structural changes were observed by HE staining and electron microscopy; the myocardium collagen content was quantified by Masson staining. To further explore the protective mechanism of SMS, we analyzed the expression profiles of fibrotic related proteins. Compared to nondiabetic mice, db/db mice exhibited enhanced diastolic myocardial dysfunction and adverse structural remodeling. Higher expression of profibrotic proteins and lower levels of extracellular matrix degradation were also observed. After SMS oral administration for 24 weeks, cardiac dysfunction, hypertrophy, and fibrosis in diabetic mice were greatly improved. Moreover, increased profibrotic protein expression was strongly reversed by SMS treatment in db/db mice. The results demonstrate that SMS exerts a cardioprotective effect against DCM by attenuating myocardial hypertrophy and fibrosis via a TGF-β dependent pathway. PMID:27200101

  2. Shengmai San Ameliorates Myocardial Dysfunction and Fibrosis in Diabetic db/db Mice.

    PubMed

    Zhao, Juan; Cao, Tong-Tong; Tian, Jing; Chen, Hui-Hua; Zhang, Chen; Wei, Hong-Chang; Guo, Wei; Lu, Rong

    2016-01-01

    In this study, we mainly investigated the effects of Shengmai San (SMS) on diabetic cardiomyopathy (DCM) in db/db mice. The db/db mice were randomly divided into model group and SMS group, while C57BLKS/J inbred mice were used as controls. After 24-week treatment, blood glucose, body weight, and heart weight were determined. Hemodynamic changes in the left ventricle were measured using catheterization. The myocardial structure and subcellular structural changes were observed by HE staining and electron microscopy; the myocardium collagen content was quantified by Masson staining. To further explore the protective mechanism of SMS, we analyzed the expression profiles of fibrotic related proteins. Compared to nondiabetic mice, db/db mice exhibited enhanced diastolic myocardial dysfunction and adverse structural remodeling. Higher expression of profibrotic proteins and lower levels of extracellular matrix degradation were also observed. After SMS oral administration for 24 weeks, cardiac dysfunction, hypertrophy, and fibrosis in diabetic mice were greatly improved. Moreover, increased profibrotic protein expression was strongly reversed by SMS treatment in db/db mice. The results demonstrate that SMS exerts a cardioprotective effect against DCM by attenuating myocardial hypertrophy and fibrosis via a TGF-β dependent pathway. PMID:27200101

  3. Stem Cell Replacement Improves Expression of SMP30 in db/db Mice

    PubMed Central

    Li, Ming; Guo, Kequan; Taketani, Shigeru; Adachi, Yasushi; Ikehara, Susumu

    2015-01-01

    We have previously reported that replacing bone marrow stem cells may improve hyperglycemia and oxidative stress in db/db mice, a type 2 diabetic mouse model. Senescence marker protein 30 (SMP30) is an antioxidant protein that decreases with aging. However, it has not been clear whether SMP30 decreases in the livers of obese mice, and whether stem cell replacement would improve SMP30 expression in the liver. Bone marrow stem cells of db/db mice were replaced with the bone marrow stem cells of C57BL/6 mice. Plasma cytokine and insulin levels were measured, and glycogen content, expression of SMP30, and fibrosis in the liver were assessed. Our results showed that stem cell replacement increased the expression of SMP30 in the liver, resulting from decreased plasma inflammation cytokines and hyperinsulinemia in db/db mice. This is the first report that stem cell replacement increased the expression of SMP30 in the liver, and may help prevent fibrosis in the liver of db/db mice. PMID:26694363

  4. Bandwidth Study on Energy Use and Potential Energy Saving Opportunities in U.S. Chemical Manufacturing

    SciTech Connect

    Sabine Brueske, Caroline Kramer, Aaron Fisher

    2015-06-01

    Energy bandwidth studies of U.S. manufacturing sectors can serve as foundational references in framing the range (or bandwidth) of potential energy savings opportunities. This bandwidth study examines energy consumption and potential energy savings opportunities in U.S. chemical manufacturing. The study relies on multiple sources to estimate the energy used in the production of 74 individual chemicals, representing 57% of sector-wide energy consumption. Energy savings opportunities for individual chemicals and for 15 subsectors of chemicals manufacturing are based on technologies currently in use or under development; these potential savings are then extrapolated to estimate sector-wide energy savings opportunity.

  5. Bandwidth Study on Energy Use and Potential Energy Savings Opportunities in U.S. Petroleum Refining

    SciTech Connect

    Sabine Brueske, Caroline Kramer, Aaron Fisher

    2015-06-01

    Energy bandwidth studies of U.S. manufacturing sectors can serve as foundational references in framing the range (or bandwidth) of potential energy savings opportunities. This bandwidth study examines energy consumption and potential energy savings opportunities in U.S. petroleum refining. The study relies on multiple sources to estimate the energy used in nine individual process areas, representing 68% of sector-wide energy consumption. Energy savings opportunities for individual processes are based on technologies currently in use or under development; these potential savings are then extrapolated to estimate sector-wide energy savings opportunity.

  6. Increased spectral bandwidths in nonlinear conversion processes by use of multicrystal designs.

    PubMed

    Brown, M

    1998-10-15

    The fourth-harmonic generation of broadband 243-nm radiation is reported. The broadband radiation is achieved by implementation of a multicrystal design to overcome spectral bandwidth limitations, and a plane-wave analysis is developed that shows increased spectral bandwidths for these designs. The fourth harmonic of a Cr:LiSAF laser operating at 972 nm is generated in beta-barium borate (BBO). The results demonstrate a spectral bandwidth at 243 nm more than five times broader than that which is expected from a single BBO crystal of equivalent length.

  7. Improving precision in resonance ionization mass spectrometry : influence of laser bandwidth in uranium isotope ratio measurements.

    SciTech Connect

    Isselhardt, B. H.; Savina, M. R.; Knight, K. B.; Pellin, M. J.; Hutcheon, I. D.; Prussin, S. G.

    2011-03-01

    The use of broad bandwidth lasers with automated feedback control of wavelength was applied to the measurement of {sup 235}U/{sup 238}U ratios by resonance ionization mass spectrometry (RIMS) to decrease laser-induced isotopic fractionation. By broadening the bandwidth of the first laser in a three-color, three-photon ionization process from a bandwidth of 1.8 GHz to about 10 GHz, the variation in sequential relative isotope abundance measurements decreased from 10% to less than 0.5%. This procedure was demonstrated for the direct interrogation of uranium oxide targets with essentially no sample preparation.

  8. High bandwidth based on a tapped delay line equalization in visible light communications

    NASA Astrophysics Data System (ADS)

    Zhang, Minglun; Guo, Xujing; Zhu, Hetian; Wang, Chao; Bai, Xiaonan; Zhai, Xiangwen

    2015-08-01

    In the visible light communication, the white LED bandwidth severely limits the transmission rate of information. This paper presents an analog pre-equalization technology to compensate for the bandwidth of white LED. The technology not only can debug according to the actual channel changing, but also avoid the high costs of using FPGA technology. The pre-equalization technology is implemented by an analog circuit of tapped-delay-line, in the circuit we select an appropriate delay line and a digital to analog converter. In our LED visible light communication system, we can achieve a bandwidth of 150MHz which was proved theoretically in the paper.

  9. Anti-diabetic and hypolipidemic effects of Sargassum yezoense in db/db mice

    SciTech Connect

    Kim, Su-Nam; Lee, Woojung; Bae, Gyu-Un; Kim, Yong Kee

    2012-08-10

    Highlights: Black-Right-Pointing-Pointer Sargassum yezoense (SY) treatment improved glucose and lipid impairment in vivo. Black-Right-Pointing-Pointer This pharmacological action is associated with PPAR{alpha}/{gamma} dual activation. Black-Right-Pointing-Pointer It decreases the expression of G6Pase for gluconeogenesis in liver. Black-Right-Pointing-Pointer It increases the expression of UCP3 for lipid metabolism in adipose tissue. Black-Right-Pointing-Pointer There are no significant side effects such as body weight gain and hepatomegaly. -- Abstract: Peroxisome proliferator-activated receptors (PPARs) have been considered to be desirable targets for metabolic syndrome, even though their specific agonists have several side effects including body weight gain, edema and tissue failure. Previously, we have reported in vitro effects of Sargassum yezoense (SY) and its ingredients, sargaquinoic acid (SQA) and sargahydroquinoic acid (SHQA), on PPAR{alpha}/{gamma} dual transcriptional activation. In this study, we describe in vivo pharmacological property of SY on metabolic disorders. SY treatment significantly improved glucose and lipid impairment in db/db mice model. More importantly, there are no significant side effects such as body weight gain and hepatomegaly in SY-treated animals, indicating little side effects of SY in liver and lipid metabolism. In addition, SY led to a decrease in the expression of G6Pase for gluconeogenesis in liver responsible for lowering blood glucose level and an increase in the expression of UCP3 in adipose tissue for the reduction of total and LDL-cholesterol level. Altogether, our data suggest that SY would be a potential therapeutic agent against type 2 diabetes and related metabolic disorders by ameliorating the glucose and lipid metabolism.

  10. 2D array transducers for real-time 3D ultrasound guidance of interventional devices

    NASA Astrophysics Data System (ADS)

    Light, Edward D.; Smith, Stephen W.

    2009-02-01

    We describe catheter ring arrays for real-time 3D ultrasound guidance of devices such as vascular grafts, heart valves and vena cava filters. We have constructed several prototypes operating at 5 MHz and consisting of 54 elements using the W.L. Gore & Associates, Inc. micro-miniature ribbon cables. We have recently constructed a new transducer using a braided wiring technology from Precision Interconnect. This transducer consists of 54 elements at 4.8 MHz with pitch of 0.20 mm and typical -6 dB bandwidth of 22%. In all cases, the transducer and wiring assembly were integrated with an 11 French catheter of a Cook Medical deployment device for vena cava filters. Preliminary in vivo and in vitro testing is ongoing including simultaneous 3D ultrasound and x-ray fluoroscopy.

  11. Demonstration of a 3-bit optical digital-to-analog converter based on silicon microring resonators.

    PubMed

    Yang, Lin; Ding, Jianfeng; Chen, Qiaoshan; Zhou, Ping; Zhang, Fanfan; Zhang, Lei

    2014-10-01

    We propose an N-bit optical digital-to-analog converter based on silicon microring resonators (MRRs), which can transform an N-bit electrical digital signal to an optical analog signal. A 3-bit optical digital-to-analog convertor is fabricated as proof of concept through a CMOS-compatible process on a silicon-on-insulator platform. The silicon MRRs are modulated through the electric-field-induced carrier injection in forward biased PN junctions embedded in the ring waveguides. The electro-optical 3-dB bandwidths of the silicon MRRs are approximately 800 MHz. The device works well at a speed of 500  MSample/s under driving voltage swings of 0.75 V.

  12. Overexpression of angiopoietin-1 increases CD133+/c-kit+ cells and reduces myocardial apoptosis in db/db mouse infarcted hearts.

    PubMed

    Zeng, Heng; Li, Lanfang; Chen, Jian-Xiong

    2012-01-01

    Hematopoietic progenitor CD133(+)/c-kit(+) cells have been shown to be involved in myocardial healing following myocardial infarction (MI). Previously we demonstrated that angiopoietin-1(Ang-1) is beneficial in the repair of diabetic infarcted hearts. We now investigate whether Ang-1 affects CD133(+)/c-kit(+) cell recruitment to the infarcted myocardium thereby mediating cardiac repair in type II (db/db) diabetic mice. db/db mice were administered either adenovirus Ang-1 (Ad-Ang-1) or Ad-β-gal systemically immediately after ligation of the left anterior descending coronary artery (LAD). Overexpression of Ang-1 resulted in a significant increase in CXCR-4/SDF-1α expression and promoted CD133(+)/c-kit(+), CD133(+)/CXCR-4(+) and CD133(+)/SDF-1α(+) cell recruitment into ischemic hearts. Overexpression of Ang-1 led to significant increases in number of CD31(+) and smooth muscle-like cells and VEGF expression in bone marrow (BM). This was accompanied by significant decreases in cardiac apoptosis and fibrosis and an increase in myocardial capillary density. Ang-1 also upregulated Jagged-1, Notch3 and apelin expression followed by increases in arteriole formation in the infarcted myocardium. Furthermore, overexpression of Ang-1 resulted in a significant improvement of cardiac functional recovery after 14 days of ischemia. Our data strongly suggest that Ang-1 attenuates cardiac apoptosis and promotes cardiac repair by a mechanism involving in promoting CD133(+)/c-kit(+) cells and angiogenesis in diabetic db/db mouse infarcted hearts. PMID:22558265

  13. Microwave absorption property of aligned MWCNT/Fe3O4

    NASA Astrophysics Data System (ADS)

    Hekmatara, H.; Seifi, M.; Forooraghi, K.

    2013-11-01

    This study investigated the microwave absorption properties of magnetic modified multiwall carbon nanotubes (MWCNTs) with different alignments to the electric field (E vector) of the incident electromagnetic (EM) waves. MWCNTs were decorated with Fe3O4 nanoparticles using the wet chemical method and the resulting MWCNT/Fe3O4 was then used as a filler in a MWCNT/Fe3O4/epoxy resin composite at different weight-to-epoxy-resin ratios (2%, 5%, and 8%) with good uniformity and alignment. For each filler concentration, three samples were produced with different alignments of carbon nanotubes using the solution-casting method. For sample one, the nanotube axis (k) was parallel to the E vector of the EM wave, for sample two, k was perpendicular to E, and the third sample contained randomly oriented nanotubes. Magnetic MWCNTs were exposed to a 0.4 T magnetic field in the desired direction to achieve the desired alignment of carbon nanotubes in epoxy resin. Microwave absorption characterization of the considered ranging band (X-band) at all concentrations where the alignment of MWCNT/Fe3O4 was parallel to the incident E vector showed increased absorption. Samples with a perpendicular alignment of MWCNT/Fe3O4 to incident E had the lowest absorption. Samples containing 2 wt% and 8 wt% MWCNT/Fe3O4 aligned parallel to E and had reflection losses exceeding 14.4 dB and 23.6 dB, respectively, over a 10-11 GHz range. The 5 wt% parallel aligned MWCNT/Fe3O4 showed an absorbing peak of 27 dB and a bandwidth broadened to 1.2 GHz.

  14. Spectra power and bandwidth of fiber Bragg grating under influence of gradient strain

    NASA Astrophysics Data System (ADS)

    Liu, Qinpeng; Qiao, Xueguang; Jia, Zhen'an; Fu, Haiwei

    2016-09-01

    The reflective spectrum power and the bandwidth of the fiber Bragg grating (FBG) under gradient strain are researched and experimentally demonstrated. The gradient strain is applied on the FBG, which can induce FBG bandwidth broadening, resulting in the variation of reflective power. Based on the coupled-mode theory and transfer matrix method, the segmental linear relationship between the gradient strain, the reflective power, and the bandwidth is simulated and analyzed, and the influence of the FBG length on the reflective spectrum is analyzed. In the experiment, the strict gradient stain device is designed; the experimental results indicate that the reflective optic power and the bandwidth of the FBG under gradient stain are concerned with the length of the FBG. Experimental results are well consistent with the theoretical analysis, which have important guiding significance in the FBG dynamic sensing.

  15. Linearly chirped microwave waveform generation with large time-bandwidth product by optically injected semiconductor laser.

    PubMed

    Zhou, Pei; Zhang, Fangzheng; Guo, Qingshui; Pan, Shilong

    2016-08-01

    A scheme for photonic generation of linearly chirped microwave waveforms (LCMWs) with a large time-bandwidth product (TBWP) is proposed and demonstrated based on an optically injected semiconductor laser. In the proposed system, the optically injected semiconductor laser is operated in period-one (P1) oscillation state. After optical-to-electrical conversion, a microwave signal can be generated with its frequency determined by the injection strength. By properly controlling the injection strength, an LCMW with a large TBWP can be generated. The proposed system has a simple and compact structure. Besides, the center frequency, bandwidth, as well as the temporal duration of the generated LCMWs can be easily adjusted. An experiment is carried out. LCMWs with TBWPs as large as 1.2x105 (bandwidth 12 GHz; temporal duration 10 μs) are successfully generated. The flexibility for tuning the center frequency, bandwidth and temporal duration is also demonstrated. PMID:27505809

  16. Analysis of blocking probability for OFDM-based variable bandwidth optical network

    NASA Astrophysics Data System (ADS)

    Gong, Lei; Zhang, Jie; Zhao, Yongli; Lin, Xuefeng; Wu, Yuyao; Gu, Wanyi

    2011-12-01

    Orthogonal Frequency Division Multiplexing (OFDM) has recently been proposed as a modulation technique. For optical networks, because of its good spectral efficiency, flexibility, and tolerance to impairments, optical OFDM is much more flexible compared to traditional WDM systems, enabling elastic bandwidth transmissions, and optical networking is the future trend of development. In OFDM-based optical network the research of blocking rate has very important significance for network assessment. Current research for WDM network is basically based on a fixed bandwidth, in order to accommodate the future business and the fast-changing development of optical network, our study is based on variable bandwidth OFDM-based optical networks. We apply the mathematical analysis and theoretical derivation, based on the existing theory and algorithms, research blocking probability of the variable bandwidth of optical network, and then we will build a model for blocking probability.

  17. Chirp measurement of large-bandwidth femtosecond optical pulses using two-photon absorption

    NASA Astrophysics Data System (ADS)

    Albrecht, T. F.; Seibert, K.; Kurz, H.

    1991-08-01

    We describe a novel method for accurate chirp measurement of broadband femtosecond pulses over their entire bandwidth based on two-photon absorption. These chirp measurements are applied for the optimization of a fiber-grating-prism pulse compressor.

  18. Very broad gain bandwidth parametric amplification in nonlinear crystals at critical wavelength degeneracy.

    PubMed

    Dabu, R

    2010-05-24

    Gain spectra were calculated at critical wavelength degeneracy (CWD) in a collinear phase-matching geometry optical parametric amplification (OPA) process. The frequency bandwidth available through CWD-OPA is broader compared to the gain bandwidth obtained by the non-collinear OPA geometry. A solution for very broad bandwidth chirped pulse amplification based on partially deuterated DKDP (P-DKDP) crystals, pumped by pulsed green lasers, is proposed. 1.38x10(14) Hz frequency bandwidth and peak intensity gain G approximately 62 were calculated in a 5-mm long 58% deuterated DKDP crystal, pumped by 527-nm wavelength at 64-GW/cm2 intensity. Parametric amplification at CWD in few-mm thin P-DKDP crystals, pumped by picosecond pulses of nearly 100-GW/cm2 intensity, possesses a true potential for generating high energy laser pulses compressible to one-cycle duration.

  19. Expanding the Bandwidth of Slow and Fast Pulse Propagation in Coupled Micro-resonators

    NASA Technical Reports Server (NTRS)

    Smith, David D.; Chang, Hongrok

    2007-01-01

    Coupled resonators exhibit coherence effects which can be exploited for the delay or advancement of pulses with minimal distortion. The bandwidth and normalized pulse delay are simultaneously enhanced by proper choice of the inter-resonator couplings.

  20. Stimulated Brillouin scattering gain bandwidth reduction and applications in microwave photonics and optical signal processing

    NASA Astrophysics Data System (ADS)

    Preussler, Stefan; Schneider, Thomas

    2016-03-01

    Stimulated Brillouin scattering (SBS) is one of the most dominant nonlinear effects in standard single-mode fibers and its unique spectral characteristics, especially the narrow bandwidth, enable many different applications. Most of the applications would benefit from a narrower bandwidth. Different methods for the bandwidth reduction of SBS in optical fibers are presented and discussed. A bandwidth reduction down to 17% of the natural gain can be achieved by the superposition of the gain with two losses or the utilization of a multistage system. Furthermore, applications in the field of microwave photonics and optical signal processing like high-resolution spectroscopy of communication signals, the storage of optical data packets as well as the processing of frequency combs including generation of millimeter waves and ideal sinc-shaped Nyquist pulses are presented.

  1. Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism

    PubMed Central

    Kim, Kyung Eun; Jung, Youngae; Min, Soonki; Nam, Miso; Heo, Rok Won; Jeon, Byeong Tak; Song, Dae Hyun; Yi, Chin-ok; Jeong, Eun Ae; Kim, Hwajin; Kim, Jeonghyun; Jeong, Seon-Yong; Kwak, Woori; Ryu, Do Hyun; Horvath, Tamas L.; Roh, Gu Seob; Hwang, Geum-Sook

    2016-01-01

    Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of liver disease and its prevalence is a serious and growing clinical problem. Caloric restriction (CR) is commonly recommended for improvement of obesity-related diseases such as NAFLD. However, the effects of CR on hepatic metabolism remain unknown. We investigated the effects of CR on metabolic dysfunction in the liver of obese diabetic db/db mice. We found that CR of db/db mice reverted insulin resistance, hepatic steatosis, body weight and adiposity to those of db/m mice. 1H-NMR- and UPLC-QTOF-MS-based metabolite profiling data showed significant metabolic alterations related to lipogenesis, ketogenesis, and inflammation in db/db mice. Moreover, western blot analysis showed that lipogenesis pathway enzymes in the liver of db/db mice were reduced by CR. In addition, CR reversed ketogenesis pathway enzymes and the enhanced autophagy, mitochondrial biogenesis, collagen deposition and endoplasmic reticulum stress in db/db mice. In particular, hepatic inflammation-related proteins including lipocalin-2 in db/db mice were attenuated by CR. Hepatic metabolomic studies yielded multiple pathological mechanisms of NAFLD. Also, these findings showed that CR has a therapeutic effect by attenuating the deleterious effects of obesity and diabetes-induced multiple complications. PMID:27439777

  2. Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism.

    PubMed

    Kim, Kyung Eun; Jung, Youngae; Min, Soonki; Nam, Miso; Heo, Rok Won; Jeon, Byeong Tak; Song, Dae Hyun; Yi, Chin-Ok; Jeong, Eun Ae; Kim, Hwajin; Kim, Jeonghyun; Jeong, Seon-Yong; Kwak, Woori; Ryu, Do Hyun; Horvath, Tamas L; Roh, Gu Seob; Hwang, Geum-Sook

    2016-01-01

    Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of liver disease and its prevalence is a serious and growing clinical problem. Caloric restriction (CR) is commonly recommended for improvement of obesity-related diseases such as NAFLD. However, the effects of CR on hepatic metabolism remain unknown. We investigated the effects of CR on metabolic dysfunction in the liver of obese diabetic db/db mice. We found that CR of db/db mice reverted insulin resistance, hepatic steatosis, body weight and adiposity to those of db/m mice. (1)H-NMR- and UPLC-QTOF-MS-based metabolite profiling data showed significant metabolic alterations related to lipogenesis, ketogenesis, and inflammation in db/db mice. Moreover, western blot analysis showed that lipogenesis pathway enzymes in the liver of db/db mice were reduced by CR. In addition, CR reversed ketogenesis pathway enzymes and the enhanced autophagy, mitochondrial biogenesis, collagen deposition and endoplasmic reticulum stress in db/db mice. In particular, hepatic inflammation-related proteins including lipocalin-2 in db/db mice were attenuated by CR. Hepatic metabolomic studies yielded multiple pathological mechanisms of NAFLD. Also, these findings showed that CR has a therapeutic effect by attenuating the deleterious effects of obesity and diabetes-induced multiple complications. PMID:27439777

  3. High-order random Raman lasing in a PM fiber with ultimate efficiency and narrow bandwidth.

    PubMed

    Babin, Sergey A; Zlobina, Ekaterina A; Kablukov, Sergey I; Podivilov, Evgeniy V

    2016-01-01

    Random Raman lasers attract now a great deal of attention as they operate in non-active turbid or transparent scattering media. In the last case, single mode fibers with feedback via Rayleigh backscattering generate a high-quality unidirectional laser beam. However, such fiber lasers have rather poor spectral and polarization properties, worsening with increasing power and Stokes order. Here we demonstrate a linearly-polarized cascaded random Raman lasing in a polarization-maintaining fiber. The quantum efficiency of converting the pump (1.05 μm) into the output radiation is almost independent of the Stokes order, amounting to 79%, 83%, and 77% for the 1(st) (1.11 μm), 2(nd) (1.17 μm) and 3(rd) (1.23 μm) order, respectively, at the polarization extinction ratio >22 dB for all orders. The laser bandwidth grows with increasing order, but it is almost independent of power in the 1-10 W range, amounting to ~1, ~2 and ~3 nm for orders 1-3, respectively. So, the random Raman laser exhibits no degradation of output characteristics with increasing Stokes order. A theory adequately describing the unique laser features has been developed. Thus, a full picture of the cascaded random Raman lasing in fibers is shown. PMID:26940082

  4. GeSn-on-Si normal incidence photodetectors with bandwidths more than 40 GHz.

    PubMed

    Oehme, Michael; Kostecki, Konrad; Ye, Kaiheng; Bechler, Stefan; Ulbricht, Kai; Schmid, Marc; Kaschel, Mathias; Gollhofer, Martin; Körner, Roman; Zhang, Wogong; Kasper, Erich; Schulze, Jörg

    2014-01-13

    GeSn (Sn content up to 4.2%) photodiodes with vertical pin structures were grown on thin Ge virtual substrates on Si by a low temperature (160 °C) molecular beam epitaxy. Vertical detectors were fabricated by a double mesa process with mesa radii between 5 µm and 80 µm. The nominal intrinsic absorber contains carrier densities from below 1 · 10(16) cm(-3) to 1 · 10(17) cm(-3) for Ge reference detectors and GeSn detectors with 4.2% Sn, respectively. The photodetectors were investigated with electrical and optoelectrical methods from direct current up to high frequencies (40 GHz). For a laser wavelength of 1550 nm an increasing of the optical responsivities (84 mA/W -218 mA/W) for vertical incidence detectors with thin (300 nm) absorbers as function of the Sn content were found. Most important from an application perspective all detectors had bandwidth above 40 GHz at enough reverse voltage which increased from zero to -5 V within the given Sn range. Increasing carrier densities (up to 1 · 10(17) cm(-3)) with Sn contents caused the depletion of the nominal intrinsic absorber at increasing reverse voltages.

  5. High-order random Raman lasing in a PM fiber with ultimate efficiency and narrow bandwidth

    PubMed Central

    Babin, Sergey A.; Zlobina, Ekaterina A.; Kablukov, Sergey I.; Podivilov, Evgeniy V.

    2016-01-01

    Random Raman lasers attract now a great deal of attention as they operate in non-active turbid or transparent scattering media. In the last case, single mode fibers with feedback via Rayleigh backscattering generate a high-quality unidirectional laser beam. However, such fiber lasers have rather poor spectral and polarization properties, worsening with increasing power and Stokes order. Here we demonstrate a linearly-polarized cascaded random Raman lasing in a polarization-maintaining fiber. The quantum efficiency of converting the pump (1.05 μm) into the output radiation is almost independent of the Stokes order, amounting to 79%, 83%, and 77% for the 1st (1.11 μm), 2nd (1.17 μm) and 3rd (1.23 μm) order, respectively, at the polarization extinction ratio >22 dB for all orders. The laser bandwidth grows with increasing order, but it is almost independent of power in the 1–10 W range, amounting to ~1, ~2 and ~3 nm for orders 1–3, respectively. So, the random Raman laser exhibits no degradation of output characteristics with increasing Stokes order. A theory adequately describing the unique laser features has been developed. Thus, a full picture of the cascaded random Raman lasing in fibers is shown. PMID:26940082

  6. Tuning gain and bandwidth of traveling wave tubes using metamaterial beam-wave interaction structures

    SciTech Connect

    Lipton, Robert Polizzi, Anthony

    2014-10-14

    We employ metamaterial beam-wave interaction structures for tuning the gain and bandwidth of short traveling wave tubes. The interaction structures are made from metal rings of uniform cross section, which are periodically deployed along the length of the traveling wave tube. The aspect ratio of the ring cross sections is adjusted to control both gain and bandwidth. The frequency of operation is controlled by the filling fraction of the ring cross section with respect to the size of the period cell.

  7. Bandwidth optimization of a Carbon Nanotubes mode-locked Erbium-doped fiber laser

    NASA Astrophysics Data System (ADS)

    Rosa, H. G.; De Souza, E. A.

    2012-03-01

    We present a new method to fabricate thin films using single-walled Carbon Nanotubes (SWCNT) and a urethane-based transparent polymer. We construct an Erbium-doped fiber laser to test our films as saturable absorbers to work as passive mode-locker. As results, pulse-trains were achieved and we carried on an optimization study involving total cavity dispersion, absorption strength of thin films incorporating SWCNT and laser bandwidth to produce broad bandwidths in passive mode-locking regime.

  8. DSS-28: a novel wide bandwidth radio telescope devoted to educational outreach

    NASA Astrophysics Data System (ADS)

    Jones, Glenn; Weinreb, Sander; Mani, Hamdi; Smith, Stephen; Teitelbaum, Lawrence; Hofstadter, Mark; Kuiper, Thomas B. H.; Imbriale, William A.; Dorcey, Ryan; Leflang, John

    2010-07-01

    We have recently equipped the 34-meter DSS-28 radio telescope at the Goldstone Deep Space Communications Complex with a novel wide bandwidth radiometer and digital signal processor as part of the Goldstone Apple Valley Radio Telescope (GAVRT) educational outreach program operated by the Jet Propulsion Laboratory and the Lewis Center for Educational Research. The system employs a cryogenically cooled wide bandwidth quad-ridge feed and InP low noise amplifiers to achieve excellent noise performance from 2.7 to 14 GHz; a fractional bandwidth better than 4:1. Four independently tunable dual-polarization receivers each down-convert a 2 GHz block to baseband, providing access to 8 GHz of instantaneous bandwidth. A flexible FPGA-based signal processor has been constructed using CASPER FPGA hardware and tools to take advantage of this enormous bandwidth. This system demonstrates many of the enabling wide bandwidth technologies that will be crucial to maximizing the utility of future large centimeter-wavelength arrays, in particular the Square Kilometer Array. The GAVRT program has previously used narrow bandwidth total power radiometers to study flux variability of quasars and the outer planets. The versatility of DSS-28 will enable other projects including spectroscopy and SETI. Finally, the wide instantaneous bandwidth available makes this system uniquely suited for studying transient radio pulses. A configuration of the digital signal processor has been developed which provides the capability of recording a burst of raw baseband voltage data triggered by a real-time incoherent dedispersion system which is very sensitive to pulses from a known source, such as the Crab Nebula pulsar.

  9. Accounting for filter bandwidth improves the quantitative accuracy of bioluminescence tomography.

    PubMed

    Taylor, Shelley L; Mason, Suzannah K G; Glinton, Sophie L; Cobbold, Mark; Dehghani, Hamid

    2015-09-01

    Bioluminescence imaging is a noninvasive technique whereby surface weighted images of luminescent probes within animals are used to characterize cell count and function. Traditionally, data are collected over the entire emission spectrum of the source using no filters and are used to evaluate cell count/function over the entire spectrum. Alternatively, multispectral data over several wavelengths can be incorporated to perform tomographic reconstruction of source location and intensity. However, bandpass filters used for multispectral data acquisition have a specific bandwidth, which is ignored in the reconstruction. In this work, ignoring the bandwidth is shown to introduce a dependence of the recovered source intensity on the bandwidth of the filters. A method of accounting for the bandwidth of filters used during multispectral data acquisition is presented and its efficacy in increasing the quantitative accuracy of bioluminescence tomography is demonstrated through simulation and experiment. It is demonstrated that while using filters with a large bandwidth can dramatically decrease the data acquisition time, if not accounted for, errors of up to 200% in quantitative accuracy are introduced in two-dimensional planar imaging, even after normalization. For tomographic imaging, the use of this method to account for filter bandwidth dramatically improves the quantitative accuracy. PMID:26325264

  10. Bandwidth of non-contact vital sign detection with a noise suppression phase locked loop

    NASA Astrophysics Data System (ADS)

    Xia, Zongyang; Zhang, Ying

    2016-04-01

    In a dual-carrier vital sign detection system, we have designed a noise suppression scheme that uses phase locked loop (PLL) to automatically suppress the noise induced by range correlation and transmission paths. The system uses two microwave carriers at 5.6 and 5.68 GHz generated by two phase locked signal generators to extract the noise and vital sign respectively. The feedback microwave signals are mixed with local 5.68-GHz signal to transfer to the vial sign signal and low frequency intermediate frequency (IF) signal. When the IF signal corresponding to 5.68 GHz microwave signal is locked to a highly stable low noise reference, the noises of IF signal and vital sign signal are suppressed as their corresponding microwave signals are highly correlated. In this system, the noise suppression performance is related to the bandwidth of the PLL, which needs to be carefully designed. Through the theoretical analysis, initial bandwidth is chosen to be 200 Hz. Then the charge pump current is changed to adjust the bandwidth and the corresponding noise suppression performance is evaluated using experiments. The results show the system with a charge pump current 0.625 mA, which corresponds to about 50 Hz bandwidth, exhibits a better noise performance. In addition, at different bandwidth, the vital sign detection system is compared with a design scheme with unlocked PLL and demonstrates superior performance at all bandwidths.

  11. Accounting for filter bandwidth improves the quantitative accuracy of bioluminescence tomography

    NASA Astrophysics Data System (ADS)

    Taylor, Shelley L.; Mason, Suzannah K. G.; Glinton, Sophie L.; Cobbold, Mark; Dehghani, Hamid

    2015-09-01

    Bioluminescence imaging is a noninvasive technique whereby surface weighted images of luminescent probes within animals are used to characterize cell count and function. Traditionally, data are collected over the entire emission spectrum of the source using no filters and are used to evaluate cell count/function over the entire spectrum. Alternatively, multispectral data over several wavelengths can be incorporated to perform tomographic reconstruction of source location and intensity. However, bandpass filters used for multispectral data acquisition have a specific bandwidth, which is ignored in the reconstruction. In this work, ignoring the bandwidth is shown to introduce a dependence of the recovered source intensity on the bandwidth of the filters. A method of accounting for the bandwidth of filters used during multispectral data acquisition is presented and its efficacy in increasing the quantitative accuracy of bioluminescence tomography is demonstrated through simulation and experiment. It is demonstrated that while using filters with a large bandwidth can dramatically decrease the data acquisition time, if not accounted for, errors of up to 200% in quantitative accuracy are introduced in two-dimensional planar imaging, even after normalization. For tomographic imaging, the use of this method to account for filter bandwidth dramatically improves the quantitative accuracy.

  12. Wide bandwidth chaotic signal generation in a monolithically integrated semiconductor laser via optical injection

    NASA Astrophysics Data System (ADS)

    Yin, Xue-Mei; Zhong, Zhu-Qiang; Zhao, Ling-Juan; Lu, Dan; Qiu, Hai-Ying; Xia, Guang-Qiong; Wu, Zheng-Mao

    2015-11-01

    Wide bandwidth chaotic signal generation in a three-section monolithically integrated semiconductor laser (MISL) under external optical injection is investigated experimentally. Through evaluating the effective bandwidth of chaotic signals, the influences of the optical injection on the bandwidth of chaotic signal from the MISL are analyzed. The experimental results indicate that, for the currents of the DFB section (IDFB) and the phase section (IP) are fixed at 70.00 mA and 34.00 mA, respectively, the effective bandwidth of chaos signal generated by the solitary MISL reaches its maximum value of 14.36 GHz when the current of the amplification section (IA) takes 23.22 mA. After an external optical injection is introduced into the MISL, the effective bandwidth of the generated chaotic signal can be beyond 2.5 times of the maximum value. Furthermore, the effects of the injection strength and the frequency detuning on the effective bandwidth of the generated chaotic signal are also discussed.

  13. An improved scheduled traffic model utilizing bandwidth splitting in elastic optical networks

    NASA Astrophysics Data System (ADS)

    Vyas, Upama; Prakash, Shashi

    2016-07-01

    The surge of traffic in today's networks gave birth to elastic optical networking paradigm. In this paper, first we propose to use the scheduled traffic model (STM) in elastic optical networks (EONs) to ensure guaranteed availability of resources to demands which enter into the network with a predetermined start and end times. In optical networks, such demands are referred to as scheduled lightpath demands (SLDs). To increase the amount of bandwidth accepted in network, next we introduce a time aware routing and spectrum assignment (TA-RSA) approach. We observed that provisioning of bulky SLDs has become more challenging in EONs due to enforcement of RSA constraints. To address this challenge, we improve the proposed STM and designed three heuristics for its implementation in EONs. In this work, we collectively refer to these heuristics as bandwidth segmented RSA (BSRSA). The improved STM (iSTM) allows splitting of SLDs in bandwidth dimension by utilizing the knowledge of attributes viz. demand holding time, overlapping in time and bandwidth requested by SLDs. Our numerical results show that BSRSA consistently outperformed over TA-RSA under all distinctive experimental cases that we considered and achieved fairness in serving heterogeneous bandwidth SLDs. The impact of splitting on the number and capacity of transponders at nodes is also gauged. It is observed that ingenious splitting of demands increases the number of resources (on links and nodes) used, and their utilization, leading to an increase in bandwidth accepted in the network.

  14. Optimum ArFi laser bandwidth for 10nm node logic imaging performance

    NASA Astrophysics Data System (ADS)

    Alagna, Paolo; Zurita, Omar; Timoshkov, Vadim; Wong, Patrick; Rechtsteiner, Gregory; Baselmans, Jan; Mailfert, Julien

    2015-03-01

    Lithography process window (PW) and CD uniformity (CDU) requirements are being challenged with scaling across all device types. Aggressive PW and yield specifications put tight requirements on scanner performance, especially on focus budgets resulting in complicated systems for focus control. In this study, an imec N10 Logic-type test vehicle was used to investigate the E95 bandwidth impact on six different Metal 1 Logic features. The imaging metrics that track the impact of light source E95 bandwidth on performance of hot spots are: process window (PW), line width roughness (LWR), and local critical dimension uniformity (LCDU). In the first section of this study, the impact of increasing E95 bandwidth was investigated to observe the lithographic process control response of the specified logic features. In the second section, a preliminary assessment of the impact of lower E95 bandwidth was performed. The impact of lower E95 bandwidth on local intensity variability was monitored through the CDU of line end features and the LWR power spectral density (PSD) of line/space patterns. The investigation found that the imec N10 test vehicle (with OPC optimized for standard E95 bandwidth of300fm) features exposed at 200fm showed pattern specific responses, suggesting areas of potential interest for further investigation.

  15. On Bandwidth Characteristics of Tuning Fork Micro-Gyroscope with Mechanically Coupled Sense Mode

    PubMed Central

    Ni, Yunfang; Li, Hongsheng; Huang, Libin; Ding, Xukai; Wang, Haipeng

    2014-01-01

    The bandwidth characteristics of a tuning fork micro-gyroscope with mechanically coupled sense mode were investigated in this paper to provide some references for mechanical bandwidth design. The concept of sense mode mechanical coupling is introduced first. Theoretical frequency response analyses were then carried out on the mechanical part of the gyroscope. Equations representing the relationships between the differential output signal and the frequency of the input angular rate were deduced in full frequency range and further simplified in low frequency range. Based on these equations, bandwidth characteristics under ideal and non-ideal conditions are discussed. Analytical results show that under ideal conditions, the bandwidth characteristics of a tuning fork micro-gyroscope are similar to those of a single mass micro-gyroscope, but under non-ideal conditions, especially when sense mass and/or stiffness are asymmetric, the bandwidth characteristics would be quite different because the in-phase mode would participate in the anti-phase vibration response. Experimental verifications were carried out on two micro-gyroscope prototypes designed in our laboratory. The deduced equations and analytical results can be used in guiding the mechanical bandwidth design of tuning fork micro-gyroscopes with mechanically coupled sense mode. PMID:25051030

  16. On bandwidth characteristics of tuning fork micro-gyroscope with mechanically coupled sense mode.

    PubMed

    Ni, Yunfang; Li, Hongsheng; Huang, Libin; Ding, Xukai; Wang, Haipeng

    2014-07-21

    The bandwidth characteristics of a tuning fork micro-gyroscope with mechanically coupled sense mode were investigated in this paper to provide some references for mechanical bandwidth design. The concept of sense mode mechanical coupling is introduced first. Theoretical frequency response analyses were then carried out on the mechanical part of the gyroscope. Equations representing the relationships between the differential output signal and the frequency of the input angular rate were deduced in full frequency range and further simplified in low frequency range. Based on these equations, bandwidth characteristics under ideal and non-ideal conditions are discussed. Analytical results show that under ideal conditions, the bandwidth characteristics of a tuning fork micro-gyroscope are similar to those of a single mass micro-gyroscope, but under non-ideal conditions, especially when sense mass and/or stiffness are asymmetric, the bandwidth characteristics would be quite different because the in-phase mode would participate in the anti-phase vibration response. Experimental verifications were carried out on two micro-gyroscope prototypes designed in our laboratory. The deduced equations and analytical results can be used in guiding the mechanical bandwidth design of tuning fork micro-gyroscopes with mechanically coupled sense mode.

  17. Serialized quantum error correction protocol for high-bandwidth quantum repeaters

    NASA Astrophysics Data System (ADS)

    Glaudell, A. N.; Waks, E.; Taylor, J. M.

    2016-09-01

    Advances in single-photon creation, transmission, and detection suggest that sending quantum information over optical fibers may have losses low enough to be correctable using a quantum error correcting code (QECC). Such error-corrected communication is equivalent to a novel quantum repeater scheme, but crucial questions regarding implementation and system requirements remain open. Here we show that long-range entangled bit generation with rates approaching 108 entangled bits per second may be possible using a completely serialized protocol, in which photons are generated, entangled, and error corrected via sequential, one-way interactions with as few matter qubits as possible. Provided loss and error rates of the required elements are below the threshold for quantum error correction, this scheme demonstrates improved performance over transmission of single photons. We find improvement in entangled bit rates at large distances using this serial protocol and various QECCs. In particular, at a total distance of 500 km with fiber loss rates of 0.3 dB km‑1, logical gate failure probabilities of 10‑5, photon creation and measurement error rates of 10‑5, and a gate speed of 80 ps, we find the maximum single repeater chain entangled bit rates of 51 Hz at a 20 m node spacing and 190 000 Hz at a 43 m node spacing for the {[[3,1,2

  18. Serialized quantum error correction protocol for high-bandwidth quantum repeaters

    NASA Astrophysics Data System (ADS)

    Glaudell, A. N.; Waks, E.; Taylor, J. M.

    2016-09-01

    Advances in single-photon creation, transmission, and detection suggest that sending quantum information over optical fibers may have losses low enough to be correctable using a quantum error correcting code (QECC). Such error-corrected communication is equivalent to a novel quantum repeater scheme, but crucial questions regarding implementation and system requirements remain open. Here we show that long-range entangled bit generation with rates approaching 108 entangled bits per second may be possible using a completely serialized protocol, in which photons are generated, entangled, and error corrected via sequential, one-way interactions with as few matter qubits as possible. Provided loss and error rates of the required elements are below the threshold for quantum error correction, this scheme demonstrates improved performance over transmission of single photons. We find improvement in entangled bit rates at large distances using this serial protocol and various QECCs. In particular, at a total distance of 500 km with fiber loss rates of 0.3 dB km-1, logical gate failure probabilities of 10-5, photon creation and measurement error rates of 10-5, and a gate speed of 80 ps, we find the maximum single repeater chain entangled bit rates of 51 Hz at a 20 m node spacing and 190 000 Hz at a 43 m node spacing for the {[[3,1,2

  19. dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes

    PubMed Central

    Singh Nanda, Jagpreet; Kumar, Rahul; Raghava, Gajendra P. S.

    2016-01-01

    We have developed a database called dbEM (database of Epigenetic Modifiers) to maintain the genomic information of about 167 epigenetic modifiers/proteins, which are considered as potential cancer targets. In dbEM, modifiers are classified on functional basis and comprise of 48 histone methyl transferases, 33 chromatin remodelers and 31 histone demethylases. dbEM maintains the genomic information like mutations, copy number variation and gene expression in thousands of tumor samples, cancer cell lines and healthy samples. This information is obtained from public resources viz. COSMIC, CCLE and 1000-genome project. Gene essentiality data retrieved from COLT database further highlights the importance of various epigenetic proteins for cancer survival. We have also reported the sequence profiles, tertiary structures and post-translational modifications of these epigenetic proteins in cancer. It also contains information of 54 drug molecules against different epigenetic proteins. A wide range of tools have been integrated in dbEM e.g. Search, BLAST, Alignment and Profile based prediction. In our analysis, we found that epigenetic proteins DNMT3A, HDAC2, KDM6A, and TET2 are highly mutated in variety of cancers. We are confident that dbEM will be very useful in cancer research particularly in the field of epigenetic proteins based cancer therapeutics. This database is available for public at URL: http://crdd.osdd.net/raghava/dbem. PMID:26777304

  20. PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine

    PubMed Central

    Lee, Ji-Hyun; Park, Kyoung Mii; Han, Dong-Jin; Bang, Nam Young; Kim, Do-Hee; Na, Hyeongjin; Lim, Semi; Kim, Tae Bum; Kim, Dae Gyu; Kim, Hyun-Jung; Chung, Yeonseok; Sung, Sang Hyun; Surh, Young-Joon; Kim, Sunghoon; Han, Byung Woo

    2015-01-01

    Despite the growing attention given to Traditional Medicine (TM) worldwide, there is no well-known, publicly available, integrated bio-pharmacological Traditional Korean Medicine (TKM) database for researchers in drug discovery. In this study, we have constructed PharmDB-K, which offers comprehensive information relating to TKM-associated drugs (compound), disease indication, and protein relationships. To explore the underlying molecular interaction of TKM, we integrated fourteen different databases, six Pharmacopoeias, and literature, and established a massive bio-pharmacological network for TKM and experimentally validated some cases predicted from the PharmDB-K analyses. Currently, PharmDB-K contains information about 262 TKMs, 7,815 drugs, 3,721 diseases, 32,373 proteins, and 1,887 side effects. One of the unique sets of information in PharmDB-K includes 400 indicator compounds used for standardization of herbal medicine. Furthermore, we are operating PharmDB-K via phExplorer (a network visualization software) and BioMart (a data federation framework) for convenient search and analysis of the TKM network. Database URL: http://pharmdb-k.org, http://biomart.i-pharm.org. PMID:26555441