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Sample records for 3 6 12

  1. FUN3D Manual: 12.6

    NASA Technical Reports Server (NTRS)

    Biedron, Robert T.; Derlaga, Joseph M.; Gnoffo, Peter A.; Hammond, Dana P.; Jones, William T.; Kleb, William L.; Lee-Rausch, Elizabeth M.; Nielsen, Eric J.; Park, Michael A.; Rumsey, Christopher L.; Thomas, James L.; Wood, William A.

    2015-01-01

    This manual describes the installation and execution of FUN3D version 12.6, including optional dependent packages. FUN3D is a suite of computational fluid dynamics simulation and design tools that uses mixed-element unstructured grids in a large number of formats, including structured multiblock and overset grid systems. A discretely-exact adjoint solver enables efficient gradient-based design and grid adaptation to reduce estimated discretization error. FUN3D is available with and without a reacting, real-gas capability. This generic gas option is available only for those persons that qualify for its beta release status.

  2. 12 CFR 3.6 - Minimum capital ratios.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Minimum capital ratios. 3.6 Section 3.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MINIMUM CAPITAL RATIOS; ISSUANCE OF DIRECTIVES Minimum Capital Ratios § 3.6 Minimum capital ratios. (a) Risk-based capital ratio. All national banks must have and maintain the...

  3. 12 CFR 3.6 - Minimum capital ratios.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Minimum capital ratios. 3.6 Section 3.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MINIMUM CAPITAL RATIOS; ISSUANCE OF DIRECTIVES Minimum Capital Ratios § 3.6 Minimum capital ratios. (a) Risk-based capital ratio. All national banks must have and maintain the...

  4. 12 CFR 3.6 - Minimum capital ratios.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Minimum capital ratios. 3.6 Section 3.6 Banks... national banks must have and maintain the minimum risk-based capital ratio as set forth in appendix A (and, for certain banks, in appendix B). (b) Total assets leverage ratio. All national banks must have...

  5. La6Sb4O12S3

    NASA Astrophysics Data System (ADS)

    Villars, P.; Cenzual, K.; Daams, J.; Gladyshevskii, R.; Shcherban, O.; Dubenskyy, V.; Kuprysyuk, V.; Savysyuk, I.

    This document is part of Subvolume A9 `Structure Types. Part 9: Space Groups (148) R-3 - (141) I41' of Volume 43 `Crystal Structures of Inorganic Compounds' of Landolt-Börnstein - Group III `Condensed Matter'.

  6. Luminescence and color center distributions in K3YB6O12:Ce3+ phosphor

    NASA Astrophysics Data System (ADS)

    Yang, Li; Wan, Yingpeng; Weng, Honggen; Huang, Yanlin; Chen, Cuili; Seo, Hyo Jin

    2016-08-01

    Polycrystalline Ce3+-doped K3YB6O12 (1–14 mol%) phosphors were prepared by facile chemical sol–gel synthesis. The phase formation of the phosphors was confirmed by x-ray powder diffraction (XRD) analysis. The photoluminescence excitation spectra (PLE), emission spectra (PL) and the luminescence decay curves were tested. Under the near-UV light, the phosphors present the emission from blue color to yellowish green due to the allowed 4f –5d transitions of Ce3+ ions. The absolute quantum efficiency (QE) of K3YB6O12:Ce3+ can reach 53% under the excitation of near-UV light. The luminescence thermal quenching of the phosphor was investigated by the temperature-dependent spectra. The crystallographic site of Ce3+ ions in the lattice was identified and discussed on the basis of luminescence characteristics and structural data. There is only one isolated Ce3+ center occupying the Y(II) sites in the lightly doped samples presenting a typical doublet emission profile. While the Ce3+ multi-centers could be created with the enhancement of the doping levels, which could induce the distinct red-shift of the spectra due to the dipole–dipole interactions. The result in this work could be useful for the further investigation of other rare earth ions in this host.

  7. Luminescence and color center distributions in K3YB6O12:Ce3+ phosphor

    NASA Astrophysics Data System (ADS)

    Yang, Li; Wan, Yingpeng; Weng, Honggen; Huang, Yanlin; Chen, Cuili; Seo, Hyo Jin

    2016-08-01

    Polycrystalline Ce3+-doped K3YB6O12 (1-14 mol%) phosphors were prepared by facile chemical sol-gel synthesis. The phase formation of the phosphors was confirmed by x-ray powder diffraction (XRD) analysis. The photoluminescence excitation spectra (PLE), emission spectra (PL) and the luminescence decay curves were tested. Under the near-UV light, the phosphors present the emission from blue color to yellowish green due to the allowed 4f -5d transitions of Ce3+ ions. The absolute quantum efficiency (QE) of K3YB6O12:Ce3+ can reach 53% under the excitation of near-UV light. The luminescence thermal quenching of the phosphor was investigated by the temperature-dependent spectra. The crystallographic site of Ce3+ ions in the lattice was identified and discussed on the basis of luminescence characteristics and structural data. There is only one isolated Ce3+ center occupying the Y(II) sites in the lightly doped samples presenting a typical doublet emission profile. While the Ce3+ multi-centers could be created with the enhancement of the doping levels, which could induce the distinct red-shift of the spectra due to the dipole-dipole interactions. The result in this work could be useful for the further investigation of other rare earth ions in this host.

  8. 17 CFR 240.3a12-6 - Definition of “common trust fund” as used in section 3(a)(12) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Definition of âcommon trust... § 240.3a12-6 Definition of “common trust fund” as used in section 3(a)(12) of the Act. The term common trust fund as used in section 3(a)(12) of the Act (15 U.S.C. 78c(a)(12)) shall include a common...

  9. 3,6,9,12-Tetrasubstituted chrysenes: synthesis, photophysical properties, and application as blue fluorescent OLED.

    PubMed

    Wu, Tien-Lin; Chou, Ho-Hsiu; Huang, Pei-Yun; Cheng, Chien-Hong; Liu, Rai-Shung

    2014-01-01

    A short synthesis of unsubstituted chrysene is described to provide a cheap source of this compound. This chrysene was used to prepare 3,6,9,12-tetrabromochrysene, which was subsequently transformed into various 3,6,9,12-tetrasubstituted chrysenes bearing four aryl, alkynyl, or amino groups by means of the Suzuki, Sonogashira, or Buchwald-Hartwig coupling reaction, respectively. These substituents result in large bathochromic shifts in the chrysene absorption and emission spectra. These new chrysene derivatives show blue fluorescent emission (401-471 nm) with high quantum yields (0.44-0.87). DFT calculations on these chrysenes rationalize well the substituent effects on their HOMO and LUMO energy levels. One representative chrysene (6g) was used as a blue fluorescent emitter in an OLED device that showed an outstanding external quantum efficiency (η = 6.31%) with blue emission [CIE (x, y) = (0.13, 0.20)] and a low turn-on voltage (3.0 V).

  10. Lattice Effective Field Theory Calculations for A=3, 4, 6, 12 Nuclei

    SciTech Connect

    Epelbaum, Evgeny; Krebs, Hermann; Lee, Dean; Meissner, Ulf-G.

    2010-04-09

    We present lattice results for the ground state energies of tritium, helium-3, helium-4, lithium-6, and carbon-12 nuclei. Our analysis includes isospin breaking, Coulomb effects, and interactions up to next-to-next-to-leading order in chiral effective field theory.

  11. 1,3,4,6,7,9-Hexamethylbenzo[1,2-c:3,4-c':5,6-c'']trithiophene: a twisted heteroarene.

    PubMed

    Wu, Yao-Ting; Tai, Chia-Cheng; Lin, Wei-Chih; Baldridge, Kim K

    2009-07-01

    1,3,4,6,7,9-Hexamethylbenzo[1,2-c:3,4-c':5,6-c'']trithiophene (C-Me) was prepared by palladium-catalyzed methylations of the corresponding hexabromide C-Br. The twisted structure of C-Me has been confirmed by X-ray crystal analysis. The physical properties of twisted C-Me and planar benzo[1,2-c:3,4-c':5,6-c'']trithiophene (C-H) were studied and compared. Crystal structures are compared to computational structures determined using density functional theory, with both the M06-2X and B3PW91 functionals.

  12. The ν_{12}+ν_6-ν_6 and ν_{11}-ν_{12} Bands of ^{12}CH_3^{13}CH_3: a Frequency Analysis Including Data from the Four Lowest Vibrational States

    NASA Astrophysics Data System (ADS)

    Moazzen-Ahmadi, N.; Oliaee, J. Norooz; Horneman, V.-M.

    2013-06-01

    High-resolution infrared spectra of the ν_{12}+ν_6-ν_6 (around 820 cm^{-1}) and ν_{11}-ν_{12} (around 370 cm^{-1}) bands of ^{12}CH_3^{13}CH_3 are assigned. Frequencies from these bands together with data from the ν_{12} and ν_5 fundamentals and the torsional bands were analysed in a 4-state fit to determine the torsion mediated Coriolis and Fermi interactions. As compared to normal ethane this lower symmetry isotopologue shows more complicated vibrational couplings. The combined data set includes more than 6800 frequencies and was fitted to within experimental accuracy using a 77-parameter Hamiltonian. The first determination of molecular parameters for the ν_{11} state of ^{12}CH_3^{13}CH_3 has been made and using this Hamiltonian we have provided lower state energies and partition functions between 100 and 330 K in increment of 10 K for planetary data analysis. A comparison with a 4-state fit of similar data for ^{12}CH_3^{12}CH_3 will be made. N. Moazzen-Ahmadi, J. Norooz Oliaee, and V.-M. Horneman, JQSRT, submitted.

  13. J depenfence in {sup 12}C({sup 6}{rvec L}i, {sup 3}He)

    SciTech Connect

    Kemper, K.W.; Green, P.V.; Kerr, P.L.

    1993-04-01

    Vector analyzing powers (VAP) for the {sup 12}C({rvec {sup 6}Li},{sup 3}He) reaction have been measured at a {rvec {sup 6}Li} bombarding energy of 34 MeV. The VAP vary between {minus}0.2 and +0.2 for the strongly excited states in {sup 15}N at 5.27, 9.83, 10.69, 13.00, 13.17 and 15.41 MeV. FRDWBA calculations are able to reproduce the sign of the analyzing powers and they give a reasonable account of the shape of the VAP angular distribution. The present data limits the spin of the previously unassigned state at 13.17 MeV to be 3/2 or 7/2 if positive parity is assumed for the state. The present data set and calculations give clear evidence for a static spin orbit potential in the {sup 6}Li entrance channel.

  14. Structure and magnetism of S = 1/2 kagome antiferromagnets NiCu3(OH)6Cl2 and CoCu3(OH)6Cl2.

    PubMed

    Li, Yue-sheng; Zhang, Qing-ming

    2013-01-16

    We have successfully synthesized S = 1/2 kagome antiferromagnets MCu(3)(OH)(6)Cl(2) (M = Ni and Co) by a hydrothermal method with a rotating pressure vessel. Structural characterization shows that both compounds have similar crystal structure to ZnCu(3)(OH)(6)Cl(2) with R3m symmetry. As with ZnCu(3)(OH)(6)Cl(2), the compounds show no obvious hysteresis at 2 K. A spin-glass transition is found in both NiCu(3)(OH)(6)Cl(2) and CoCu(3)(OH)(6)Cl(2) at low temperatures (6.0 and 3.5 K respectively) by AC susceptibility measurements. This indicates no long-range magnetic order and a strong spin frustration. The substitution of Zn(2+) by magnetic ions Ni(2+) or Co(2+) effectively enhances the interlayer exchange coupling and changes the ground state of the kagome spin system.

  15. Structure and magnetism of S = 1/2 kagome antiferromagnets NiCu3(OH)6Cl2 and CoCu3(OH)6Cl2

    NASA Astrophysics Data System (ADS)

    Li, Yue-sheng; Zhang, Qing-ming

    2013-01-01

    We have successfully synthesized S = 1/2 kagome antiferromagnets MCu3(OH)6Cl2 (M = Ni and Co) by a hydrothermal method with a rotating pressure vessel. Structural characterization shows that both compounds have similar crystal structure to ZnCu3(OH)6Cl2 with R\\bar {3}m symmetry. As with ZnCu3(OH)6Cl2, the compounds show no obvious hysteresis at 2 K. A spin-glass transition is found in both NiCu3(OH)6Cl2 and CoCu3(OH)6Cl2 at low temperatures (6.0 and 3.5 K respectively) by AC susceptibility measurements. This indicates no long-range magnetic order and a strong spin frustration. The substitution of Zn2+ by magnetic ions Ni2+ or Co2+ effectively enhances the interlayer exchange coupling and changes the ground state of the kagome spin system.

  16. Volumetric Properties of the Mixture Dimethyl carbonate C3H6O3 + C6H12O3 2,4,6-Trimethyl-1,3,5-trioxane (VMSD1111, LB4518_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume C 'Binary Liquid Systems of Nonelectrolytes III' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Dimethyl carbonate C3H6O3 + C6H12O3 2,4,6-Trimethyl-1,3,5-trioxane (VMSD1111, LB4518_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  17. Volumetric Properties of the Mixture Dimethyl carbonate C3H6O3 + C6H12O3 2,4,6-Trimethyl-1,3,5-trioxane (VMSD1212, LB4519_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume C 'Binary Liquid Systems of Nonelectrolytes III' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Dimethyl carbonate C3H6O3 + C6H12O3 2,4,6-Trimethyl-1,3,5-trioxane (VMSD1212, LB4519_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  18. Volumetric Properties of the Mixture Dimethyl carbonate C3H6O3 + C6H12O3 2,4,6-Trimethyl-1,3,5-trioxane (VMSD1511, LB4517_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume C 'Binary Liquid Systems of Nonelectrolytes III' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Dimethyl carbonate C3H6O3 + C6H12O3 2,4,6-Trimethyl-1,3,5-trioxane (VMSD1511, LB4517_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  19. A New Niobium Cluster Oxychloride Built from Interconnected Nb 6Cl 12O 6 Units: Na 0.21Nb 6Cl 10.5O 3

    NASA Astrophysics Data System (ADS)

    Gulo, Fakhili; Perrin, Christiane

    2002-01-01

    The new Na0.21Nb6Cl10.5O3 oxychloride was synthesized by a solid state route, from NaCl, Nb2O5, NbCl5, and Nb, heated at 680°C for 2 weeks. The structure was determined by single-crystal X-ray diffraction. It crystallizes in the trigonal system (Roverline3c space group, a=11.5048(1) Å, c=44.9446(7) Å, V=5151.88(10) Å3, Z=12). The structure is built from [(Nb6Cli9Oi3) Oa3Cla3] units, which share their inner and apical oxygens forming pseudolayers with short Nb-Nb intercluster distances (3.399 Å). Along the c axis, these layers are interconnected by apical-apical chlorines. The sodium atoms are randomly distributed in the voids arranged between two adjacent layers, in a deformed chlorine prismatic coordination. The developed formula Na0.21 [(Nb6Cli9Oi-a3/2)Oa-i3/2Cla-a3/2] leads to a number of valence electrons per cluster close to 14. This oxychloride will be compared to CsNb6Cl12O2 which we have previously isolated and which was the first example of a Nb6 oxyhalide involving Oi-a, Oa-i interunit connections.

  20. Radar observations at 3.5 and 12.6 cm wavelength of asteroid 433 Eros

    NASA Technical Reports Server (NTRS)

    Jurgens, R. F.; Goldstein, R. M.

    1976-01-01

    A study of the asteroid 433 Eros using 3.5 and 12.6 cm radar waves indicates that the surface is very much rougher than any planetary or lunar surface observed by this method. A surface completely covered with sharp edges, pits, subsurface holes, or embedded chunks with scale sizes on the order of our wavelengths seems to be indicated. A model based on a rough rotating triaxial ellipsoid having radii in the rotation equator of 18.6 and 7.9 km agrees well with our data, although a strong wobble in the apparent center frequency of the spectra as rotation progresses indicates that one side may be more reflective than the other, or more likely, that the projected axis of rotation does not equally divide the projected area.

  1. Na3.6Al3.6Si12.4O32•14H2O

    NASA Astrophysics Data System (ADS)

    Villars, P.; Cenzual, K.; Daams, J.; Gladyshevskii, R.; Shcherban, O.; Dubenskyy, V.; Kuprysyuk, V.; Savysyuk, I.

    This document is part of Subvolume A9 `Structure Types. Part 9: Space Groups (148) R-3 - (141) I41' of Volume 43 `Crystal Structures of Inorganic Compounds' of Landolt-Börnstein - Group III `Condensed Matter'.

  2. 12 CFR 12.6 - Fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Fees. 12.6 Section 12.6 Banks and Banking... SECURITIES TRANSACTIONS § 12.6 Fees. A national bank may charge a reasonable fee for providing notification pursuant to § 12.5(b), (c), and (e). A national bank may not charge a fee for providing...

  3. Hydrothermal synthesis of Yb3+, Tm3+ co-doped Gd6MoO12 and its upconversion properties

    NASA Astrophysics Data System (ADS)

    Di, Qiu-Mei; Sun, Yu-Mei; Xu, Qi-Guang; Han, Liu; Xue, Bing; Sun, Jia-Yue

    2015-06-01

    Yb3+, Tm3+ co-doped Gd6MoO12 phosphors with different morphologies are prepared by the hydrothermal method. The dendrites present different morphologies (including hexagonal prisms, spindles, and spheres) after changing the pH value and edetate disodium (EDTA) usage. It is found that each of the two factors plays a crucial role in forming different morphologies. The up-conversion (UC) luminescence is studied. Under 980-nm semiconductor laser excitation, relatively strong blue emission and weak red emission are observed. Finally, the effect of pumping power on the UC luminescence properties and the level diagram mechanism of Gd6MoO12:Yb3+/Tm3+ phosphor are also discussed. Project supported by the National Natural Science Foundation of China (Grant No. 20976002), the Beijing Natural Science Foundation, China (Grant No. 2122012), the Key Projects for Science and Technology of Beijing Education Commission, China (Grant No. KZ201310011013), and the Education and Research Fund of Guangdong Province, China (Grant No. 2011B090400100).

  4. Europium gallium garnet (Eu3Ga5O12) and Eu3GaO6: Synthesis and material properties

    NASA Astrophysics Data System (ADS)

    Sawada, Kenji; Nakamura, Toshihiro; Adachi, Sadao

    2016-10-01

    Eu-Ga-O ternary compounds were synthesized from a mixture of cubic (c-) Eu2O3 and monoclinic Ga2O3 (β-Ga2O3) raw powders using the solid-state reaction method by calcination at Tc = 1200 °C. The structural and optical properties of the Eu-Ga-O ternary compounds were investigated using X-ray diffraction analysis, photoluminescence (PL) analysis, PL excitation (PLE) spectroscopy, and Raman scattering measurements. Stoichiometric compounds such as cubic Eu3Ga5O12 (EGG) and orthorhombic Eu3GaO6 were synthesized using molar ratios of x = 0.375 and 0.75 [x≡Eu2O3/(Eu2O3 + Ga2O3)], respectively, together with the end-point binary compounds β-Ga2O3 (x = 0) and monoclinic (m-) Eu2O3 (x = 1.0). The structural change from "cubic" to "monoclinic" in Eu2O3 is due to the structural phase transition occurring at Tc ≥ 1050 °C. In principle, the perovskite-type EuGaO3 and monoclinic Eu4Ga2O9 can also be synthesized at x = 0.5 and 0.667, respectively; however, such stoichiometric compounds could not be synthesized in this study. The PL and PLE properties of EGG and Eu3GaO6 were studied in detail. The temperature dependence of the PL spectra was observed through measurements carried out between T = 20 and 300 K and explained using a newly developed model. Raman scattering measurements were also performed on the Eu-Ga-O ternary systems over the entire composition range from x = 0 (β-Ga2O3) to 1.0 (m-Eu2O3).

  5. 3-[Chloro-(phen-yl)meth-yl]-6-methyl-1,2-benzoxazole.

    PubMed

    Kayalvizhi, M; Vasuki, G; Ramamurthi, K; Veerareddy, A; Laxminarasimha, G

    2011-11-01

    The title compound, C(15)H(12)ClNO, is a functionalized 1,2-benzoxazole with a chloro-(phen-yl)methyl substituent. The mol-ecule is V-shaped, the dihedral angle between the mean plane of the 1,2-benzoxazole system [maximum deviation = 0.023 (3) Å for the N atom] and the phenyl ring being 70.33 (14)°. There are no hydrogen-bonding inter-actions in the crystal structure, which is stabilized by van der Waals inter-actions only.

  6. 12 CFR 563d.3b-6 - Liability for certain statements by savings associations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... savings associations. This section replaces adherence to 17 CFR 240.3b-6 and applies as follows: (a) A... registration statement filed with the Office under the Act on Form 10 (17 CFR 249.210); in part I of a quarterly report filed with the Office on Form 10-Q (17 CFR 241.308a); in an annual report to...

  7. 12 CFR 563d.3b-6 - Liability for certain statements by savings associations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... savings associations. This section replaces adherence to 17 CFR 240.3b-6 and applies as follows: (a) A... registration statement filed with the Office under the Act on Form 10 (17 CFR 249.210); in part I of a quarterly report filed with the Office on Form 10-Q (17 CFR 241.308a); in an annual report to...

  8. 12 CFR 563d.3b-6 - Liability for certain statements by savings associations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... savings associations. This section replaces adherence to 17 CFR 240.3b-6 and applies as follows: (a) A... registration statement filed with the Office under the Act on Form 10 (17 CFR 249.210); in part I of a quarterly report filed with the Office on Form 10-Q (17 CFR 241.308a); in an annual report to...

  9. [μ-6,9-Bis(carboxylatomethyl)-3,12-bis(car­boxymethyl)-3,6,9,12-tetraaza­tetradecanedioato]bis­[aqua­cobalt(II)] tetra­hydrate

    PubMed Central

    Qian, Qi-feng; Wu, Jin-hui; Qian, Jin-liang

    2013-01-01

    The binuclear title complex, [Co2(C18H26N4O12)(H2O)2]·4H2O, lies about a centre of inversion, the CoII atom being coordinated in a distorted octa­hedral arrangement defined by one water mol­ecule and N2O3 donors derived from one end of a 6,9-bis(carboxylatomethyl)-3,12-bis(car­boxy­methyl)-3,6,9,12-tetraaza­tetradecanedioate (H2TTHA4−) tetra­anion. In the crystal, numerous O—H⋯O hydrogen bonds link the mol­ecules into a three-dimensional network. PMID:23424439

  10. [μ-6,9-Bis(carboxylatomethyl)-3,12-bis(car-boxymethyl)-3,6,9,12-tetraaza-tetradecanedioato]bis-[aqua-cobalt(II)] tetra-hydrate.

    PubMed

    Qian, Qi-Feng; Wu, Jin-Hui; Qian, Jin-Liang

    2013-02-01

    The binuclear title complex, [Co(2)(C(18)H(26)N(4)O(12))(H(2)O)(2)]·4H(2)O, lies about a centre of inversion, the Co(II) atom being coordinated in a distorted octa-hedral arrangement defined by one water mol-ecule and N(2)O(3) donors derived from one end of a 6,9-bis(carboxylatomethyl)-3,12-bis(car-boxy-methyl)-3,6,9,12-tetraaza-tetradecanedioate (H(2)TTHA(4-)) tetra-anion. In the crystal, numerous O-H⋯O hydrogen bonds link the mol-ecules into a three-dimensional network. PMID:23424439

  11. Analysis of the Infrared Spectra of the Fundamentals nu3 and nu6 of 12CD3I and 13CD3I

    PubMed

    Koivusaari

    1997-09-01

    The high-resolution infrared spectra of the lowest fundamental bands nu3 and nu6 of 12CD3I and 13CD3I have been measured using a Fourier transform spectrometer. The bands are analyzed on one hand by taking into account the Coriolis resonance nu3/nu6 and on the other hand without this Coriolis effect. The molecular constants obtained for the two vibration modes are introduced and a discussion of the influence of the Coriolis interaction to the parameter set is shortly outlined. Copyright 1997 Academic Press. Copyright 1997Academic Press

  12. [N6-dipeptide derivatives of the N12-ribosyl-indolo[2,3-a]carbazole].

    PubMed

    Goryunova, O V; Zakharchuk, G M; Zhukova, O S; Fetisova, L V; Kuzmina, N E

    2014-01-01

    N6-derivatives of N12-ribosyl-indolo[2,3-a]pirrolo[3,4-c]carbazole-5,7-dione are synthesized as potential antitumor agents, in which an atom of N6-pyrrole part of heterocycle is included into the dipeptide residual of the general formula >N6-(CH2)n-CO-Ala/βAla-OMe (n = 2 or 3). These compounds are derived by reacting of 13-methyl-12-(2,3,4-three-O-acetyl-β-D-ribopyranosyl)indolo[2,3-a]furano[3,4-c] carbazole-5,7-dione with dipeptides, having an unreplaced N-amino end-group, in DMF at 130°C, wherein the nitrogen atom of peptide amino group replaces oxygen O6 in furan ring of heterocycle and is embedded in imide nitrogen atom of pyrrole N6. The ability of the obtained compounds to inhibit growth of SKOV3 human ovarian carcinoma cells was studied, only derivative with radical >N6-(CH2)3-CO-L-Ala-OMe showed cytotoxic activity with an inhibitory concentration of IC50 = 8 μM. PMID:25898719

  13. Lasing in a Tm:Ho:Yb3Al5O12 crystal pumped into the 3H6 - 3F4 transition

    NASA Astrophysics Data System (ADS)

    Zavartsev, Yu D.; Zagumennyi, A. I.; Kalachev, Yu L.; Kutovoi, S. A.; Mikhailov, V. A.; Shcherbakov, I. A.

    2016-03-01

    A growth technology has been developed, and a Tm:Ho:Yb3Al5O12 laser crystal of high optical quality has been grown by Czochralski method. Its spectral and luminescent characteristics are studied. Lasing at a wavelength of 2100 nm is obtained under pumping into the absorption line on the 3H6 - 3F4 transition of the Tm3+ ion at a wavelength of 1678 nm. The slope and total (optical) efficiencies of the laser at an output power of up to 320 mW reach 41% and 30%, respectively.

  14. Bromine-rich Zinc Bromides: Zn6Br12(18-crown-6)2×(Br2)5, Zn4Br8(18-crown-6)2×(Br2)3, and Zn6Br12(18-crown-6)2×(Br2)2.

    PubMed

    Hausmann, David; Feldmann, Claus

    2016-06-20

    The bromine-rich zinc bromides Zn6Br12(18-crown-6)2×(Br2)5 (1), Zn4Br8(18-crown-6)2×(Br2)3 (2), and Zn6Br12(18-crown-6)2×(Br2)2 (3) are prepared by reaction of ZnBr2, 18-crown-6, and elemental bromine in the ionic liquid [MeBu3N][N(Tf)2] (N(Tf)2 = bis(trifluoromethylsulfonyl)amide). Zn6Br12(18-crown-6)2×(Br2)5 (1) is formed instantaneously by the reaction. Even at room temperature, compound 1 releases bromine, which was confirmed by thermogravimetry (TG) and mass spectrometry (MS). The release of Br2 can also be directly followed by the color and density of the title compounds. With controlled conditions (2 weeks, 25 °C, absence of excess Br2) Zn6Br12(18-crown-6)2×(Br2)5 (1) slowly releases bromine with conconcurrent generation of Zn4Br8(18-crown-6)2×(Br2)3 (2) (in ionic liquid) and Zn6Br12(18-crown-6)2×(Br2)2 (3) (in inert oil). All bromine-rich zinc bromides contain voluminous uncharged (e.g., Zn3Br6(18-crown-6), Zn2Br4(18-crown-6)) or ionic (e.g., [Zn2Br3(18-crown-6)](+), [(Zn2Br6)×(Br2)2](2-)) building units with dibromine molecules between the Zn oligomers and partially interconnecting the Zn-containing building units. Due to the structural similarity, the bromine release is possible via crystal-to-crystal transformation with retention of the crystal shape. PMID:27281122

  15. Bromine-rich Zinc Bromides: Zn6Br12(18-crown-6)2×(Br2)5, Zn4Br8(18-crown-6)2×(Br2)3, and Zn6Br12(18-crown-6)2×(Br2)2.

    PubMed

    Hausmann, David; Feldmann, Claus

    2016-06-20

    The bromine-rich zinc bromides Zn6Br12(18-crown-6)2×(Br2)5 (1), Zn4Br8(18-crown-6)2×(Br2)3 (2), and Zn6Br12(18-crown-6)2×(Br2)2 (3) are prepared by reaction of ZnBr2, 18-crown-6, and elemental bromine in the ionic liquid [MeBu3N][N(Tf)2] (N(Tf)2 = bis(trifluoromethylsulfonyl)amide). Zn6Br12(18-crown-6)2×(Br2)5 (1) is formed instantaneously by the reaction. Even at room temperature, compound 1 releases bromine, which was confirmed by thermogravimetry (TG) and mass spectrometry (MS). The release of Br2 can also be directly followed by the color and density of the title compounds. With controlled conditions (2 weeks, 25 °C, absence of excess Br2) Zn6Br12(18-crown-6)2×(Br2)5 (1) slowly releases bromine with conconcurrent generation of Zn4Br8(18-crown-6)2×(Br2)3 (2) (in ionic liquid) and Zn6Br12(18-crown-6)2×(Br2)2 (3) (in inert oil). All bromine-rich zinc bromides contain voluminous uncharged (e.g., Zn3Br6(18-crown-6), Zn2Br4(18-crown-6)) or ionic (e.g., [Zn2Br3(18-crown-6)](+), [(Zn2Br6)×(Br2)2](2-)) building units with dibromine molecules between the Zn oligomers and partially interconnecting the Zn-containing building units. Due to the structural similarity, the bromine release is possible via crystal-to-crystal transformation with retention of the crystal shape.

  16. Structural and light up-conversion luminescence properties of Er3+-Yb3+-W6+ substituted Bi4Ti3O12

    NASA Astrophysics Data System (ADS)

    Bokolia, Renuka; Rai, Vineet K.; Chauhan, Lalita; Sreenivas, K.

    2016-05-01

    The structural and light up-conversion (UC) luminescence properties of W6+ substituted Bi3.79Er0.03Yb0.18Ti3-xWxO12 (0 ≤ x ≤ 0.10) ceramics prepared by solid state reaction method have been investigated. X-ray diffraction (XRD) confirms the formation of single phase material with orthorhombic structure. A decrease in the lattice parameters and unit cell volume is observed with increasing W content. Strong UC luminescence at 527, 548 and 662 nm is seen under an excitation of 980 nm for an optimum W content (x = 0.06) and is attributed to the transitions 2H11/2 →4I15/2, 4S3/2 →4I15/2 and 4F9/2 →4I15/2 respectively. The improved UC luminescence is ascribed to the reduced defects such as oxygen vacancies and change in the crystal field around Er3+ ions due to B-site (Ti4+) substitution with W6+ ions. Enhanced UC emission is observed for an optimum content of w6+ in the prepared composition Bi3.79Er0.03Yb0.18Ti3-xWxO12 for x = 0.06.

  17. School-Based Interventions for Anxious Children: 3-, 6-, and 12-Month Follow-Ups

    ERIC Educational Resources Information Center

    Bernstein, Gail A.; Bernat, Debra H.; Victor, Andrea M.; Layne, Ann E.

    2008-01-01

    The study followed participants aged 7 to 11 years from a previous study that compared three school-based cognitive-behavioral therapy (CBT) interventions for anxious children to determine long-term post-treatment benefits. Results indicate school-based CBT decreases anxiety symptoms up to 12 months post-treatment.

  18. Conformational comparison of 1,2-dimethyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile free base and its hydrobromide monohydrate salt.

    PubMed

    Cody, V; Suwínska, K; Wojtczak, A

    1991-01-15

    C13H11N3O (I), Mr = 225.25, monoclinic, P21/c, a = 11.713 (4), b = 7.891 (3), c = 12.154 (4) A, beta = 92.27 (4) degrees, V = 1123 (1) A3, Z = 4, Dx = 1.333 Mg m-3, lambda (Mo K alpha) = 0.71073 A, mu = 0.082 mm-1, F(000) = 472, T = 293 K, R = 0.063 for 2579 reflections. 5-cyano-1,2-dimethyl-6-oxo-1,6-dihydro-3,4'-bipyridinium bromide monohydrate, C13H12N3O+.Br-.H2O (II), Mr = 324.18, orthorhombic, Pbca, a = 7.2893 (8), b = 18.955 (3), c = 19.814 (3) A, V = 2738 (1) A3, Z = 8, Dx = 1.573 Mg m-3, lambda (Mo K alpha) = 0.71073 A, mu = 2.972 mm-1, F(000) = 1312, T = 293 K, R = 0.086 for 2292 reflections. The twist angle around the bipyridine C(1)-C(1)' bond is 66.6 (2) and 44.1 (8) degrees for the free base (I) and its salt (II), respectively. The larger C(3)'-N(4)'-C(5)' pyridine ring angle [121.8 (5) degrees] in the salt structure compared with the corresponding value for the free base [116.1 (1) degrees] suggests that N(4)' is a protonation site. The water molecule in the salt structure (II) is disordered with occupancy refined to 0.6 and 0.4.

  19. Stereoselective synthesis of (all-Z)-hentriaconta-3,6,9,12,15,19,22,25,28-nonaene.

    PubMed

    Filippova, Liudmila; Aarum, Ida; Ringdal, Martine; Dahl, Martin Kirkhus; Hansen, Trond Vidar; Stenstrøm, Yngve

    2015-04-28

    Several microorganisms produce small quantities of polyunsaturated hydrocarbons and such natural products are of interest. Starting from the ethyl ester of eicosapentaenoic acid, the total synthesis of the natural product (all-Z)-hentriaconta-3,6,9,12,15,19,22,25,28-nonaene has been achieved in eight steps and 15% overall yield. The synthesis is based on a stereoselective Wittig reaction and confirms the all-Z-configuration of the nine double bonds in this highly unsaturated natural product.

  20. Single crystal growth and structural characterization of four complex uranium oxides: CaUO4, β-Ca3UO6, K4CaU3O12, and K4SrU3O12

    NASA Astrophysics Data System (ADS)

    Read, Cory M.; Bugaris, Daniel E.; zur Loye, Hans-Conrad

    2013-03-01

    Single crystals of complex uranium oxides, CaUO4, β-Ca3UO6, K4CaU3O12 and K4SrU3O12 were grown from carbonate melts. The crystal structures of the four uranates were determined by single crystal X-ray diffraction. CaUO4 crystallizes in the hexagonal space group R-3m, with lattice parameters a = 6.2570(7) Å and α = 36.04(2)°. The U6+ atom in CaUO4 is 8-coordinate and exhibits hexagonal bipyramidal geometry with six long and two short U-O bonds, typical of a uranyl species. β-Ca3UO6 forms in the monoclinic space group P21/n, with lattice parameters a = 5.728(1) Å, b = 5.956(1) Å, c = 8.298(2) Å, and β = 90.55(3)°, and adopts a distorted double perovskite structure. K4CaU3O12 and K4SrU3O12 crystallize in the cubic space group Im-3m with lattice parameters a = 8.483(1) Å and a = 8.582(1) Å, respectively. In all three perovskite-type oxides, the U(VI) cation is located in an octahedral coordination environment and exhibits typical uranyl geometry with four long and two short U-O bonds.

  1. New observation and combined analysis of the Cs{sub 2} 0{sub g}{sup −}, 0{sub u}{sup +}, and 1{sub g} states at the asymptotes 6S{sub 1/2} + 6P{sub 1/2} and 6S{sub 1/2} + 6P{sub 3/2}

    SciTech Connect

    Ma, Jie; Liu, Wenliang; Wu, Jizhou; Jia, Suotang; Yang, Jinxin; Dai, Xingcan; Sun, Weiguo; Ivanov, Valery S.; Skublov, Alexei S.; Sovkov, Vladimir B.

    2014-12-28

    We report on new observations of the photoassociation spectroscopy of ultracold cesium molecules using a highly sensitive detection technique and a combined analysis with all observed electronic states. The technique is achieved by directly modulating the frequency of the trapping lasers of a magneto-optical trap. New observations of the Cs{sub 2}0{sub g}{sup −}, 0{sub u}{sup +}, and 1{sub g} states at the asymptotes 6S{sub 1/2} + 6P{sub 1/2} and 6S{sub 1/2} + 6P{sub 3/2} are reported. The spectral range is extended to the red detuning of 112 cm{sup −1} below the 6S{sub 1/2} + 6P{sub 3/2} dissociation limit. Dozens of vibrational levels of the ultracold Cs{sub 2}0{sub g}{sup −}, 0{sub u}{sup +}, and 1{sub g} states are observed for the first time. The available experimental binding energies of these states are analyzed simultaneously in a framework of the generalized LeRoy–Bernstein theory and the almost degenerate perturbation theory by Marinescu and Dalgarno [Phys. Rev. A: At., Mol., Opt. Phys. 52, 311 (1995)]. The unique atomic-related parameter c{sub 3} governing the dispersion forces of all the molecular states is estimated as (10.29 ± 0.05) a.u.

  2. New example of spontaneous resolution among aryl glycerol ethers: 3-(2,6-dichlorophenoxy)propane-1,2-diol

    NASA Astrophysics Data System (ADS)

    Bredikhina, Zemfira A.; Kurenkov, Alexey V.; Zakharychev, Dmitry V.; Krivolapov, Dmitry B.; Bredikhin, Alexander A.

    2016-08-01

    Using a set of simple tests, based on the properties of ideal conglomerate phase diagrams, it has been suggested to the conglomerate-formative nature of 3-(2,6-dichlorophenoxy)-propane-1,2-diol 1. Additional arguments have been drawn during the study of a single crystal X-ray diffraction study of the compound. The crystal packing details have been evaluated and discussed. Racemic 1 have been resolved into individual (S)- and (R)-components by a preferential crystallization procedure.

  3. Synthesis of Substituted 2,3,5,6-tetraarylbenzo(1,2-b:5,4-b')difurans

    NASA Technical Reports Server (NTRS)

    Abdul-Aziz, Mahmoud; Auping, Judith V.; Meador, Michael A.

    1995-01-01

    A series of substituted 2,3,5,6-tetraarylbenzo(l,2-b:5,4-b')difurans 1 was synthesized. This synthesis is based upon the photocyclization of 2,5-dibenzoylresorcinol dibenzyl ethers to the corresponding tetrahydrobenzo(1,2-b:5,4-b')difurans. Treatment of the photoproducts with methanesulfonyl chloride in pyridine afforded 1 in overall yields ranging from 30-72%. A number of these compounds have high fluorescence quantum yields (of phi(sub f) = 0.76-0.90), and their fluorescence spectra exhibit large solvatochromic shifts. These compounds may be suitable for use as fluorescent probes.

  4. Hierarchical cobalt-formate framework series with (4{sup 12}⋅6{sup 3})(4{sup 9}⋅6{sup 6}){sub n} (n = 1–3) topologies exhibiting slow dielectric relaxation and weak ferromagnetism

    SciTech Connect

    Shang, Ran; Chen, Sa; Hu, Ke-Li; Jiang, Ze-Chun; Wang, Bing-Wu; Wang, Zhe-Ming E-mail: gaosong@pku.edu.cn; Gao, Song E-mail: gaosong@pku.edu.cn; Kurmoo, Mohamedally

    2014-12-01

    The employment of linear di-, tri-, and tetra-ammoniums has generated a hierarchy in the binodal (4{sup 12}⋅6{sup 3})(4{sup 9}⋅6{sup 6}){sub n} topologies with n = 1, 2, and 3, respectively, for the cobalt formate frameworks with increasing length of the cavities to match the ammoniums. This indicates the length-directing effect of the polyammoniums. The dynamic movements of polyammoniums between favored sites or orientations within the cavities lead to slow dielectric relaxations. All materials are spin-canted antiferromagnets in low temperatures and show reduced spontaneous magnetizations from di- and tri-, to tetra-ammoniums, because of the increased number of unique Co ions or the antiferromagnetically coupled sublattices.

  5. Antioxidant properties and PC12 cell protective effects of a novel curcumin analogue (2E,6E)-2,6-bis(3,5- dimethoxybenzylidene)cyclohexanone (MCH).

    PubMed

    Ao, Gui-Zhen; Chu, Xiao-Jing; Ji, Yuan-Yuan; Wang, Jian-Wen

    2014-03-05

    The antioxidative properties of a novel curcumin analogue (2E,6E)-2,6-bis(3,5-dimethoxybenzylidene)cyclohexanone (MCH) were assessed by several in vitro models, including superoxide anion, hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and PC12 cell protection from H2O2 damage. MCH displayed superior O2•- quenching abilities compared to curcumin and vitamin C. In vitro stability of MCH was also improved compared with curcumin. Exposure of PC12 cells to 150 µM H2O2 caused a decrease of antioxidant enzyme activities, glutathione (GSH) loss, an increase in malondialdehyde (MDA) level, and leakage of lactate dehydrogenase (LDH), cell apoptosis and reduction in cell viability. Pretreatment of the cells with MCH at 0.63-5.00 µM before H2O2 exposure significantly attenuated those changes in a dose-dependent manner. MCH enhanced cellular expression of transcription factor NF-E2-related factor 2 (Nrf2) at the transcriptional level. Moreover, MCH could mitigate intracellular accumulation of reactive oxygen species (ROS), the loss of mitochondrial membrane potential (MMP), and the increase of cleaved caspase-3 activity induced by H2O2. These results show that MCH protects PC12 cells from H2O2 injury by modulating endogenous antioxidant enzymes, scavenging ROS, activating the Nrf2 cytoprotective pathway and prevention of apoptosis.

  6. Magic wavelengths for the 7s1/26d3/2,5/2 transitions in Ra+

    NASA Astrophysics Data System (ADS)

    Wu, Xiao-Mei; Li, Cheng-Bin; Tang, Yong-Bo; Shi, Ting-Yun

    2016-09-01

    The dynamic polarizabilities of the 7s and 6d states of Ra+ are calculated using a relativistic core polarization potential method. The magic wavelengths of the 7s1/26d3/2,5/2 transitions are identified. Comparing to the common radio-frequency (RF) ion traps, using the laser field at the magic wavelength to trap the ion could suppress the frequency uncertainty caused by the micromotion of the ion, and would not affect the transition frequency measurements. The heating rates of the ion and the powers of the laser for the ion trapping are estimated, which would benefit the possible precision measurements based on all-optical trapped Ra+. Project supported by the National Basic Research Program of China (Grant No. 2012CB821305) and the National Natural Science Foundation of China (Grant Nos. 91336211 and 11504094).

  7. Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.

    PubMed

    Xie, Feng; Liu, Wei; Feng, Fen; Li, Xin; He, Lu; Lv, Deguan; Qin, Xuping; Li, Lifang; Li, Lanfang; Chen, Linxi

    2015-12-01

    Apelin is highly expressed in rat left ventricular hypertrophy Sprague Dawley rat models, and it plays a crucial role in the cardiovascular system. The aim this study was to clarify whether apelin-13 promotes hypertrophy in H9c2 rat cardiomyocytes and to investigate its underlying mechanism. The cardiomyocyte hypertrophy was observed by measuring the diameter, volume, and protein content of H9c2 cells. The activation of autophagy was evaluated by observing the morphology of autophagosomes by transmission electron microscopy, observing the subcellular localization of LC3 by light microscopy, and detecting the membrane-associated form of LC3 by western blot analysis. The phosphatidylinositol 3-kinase (PI3K) signaling pathway was identified and the proteins expression was detected using western blot analysis. The results revealed that apelin-13 increased the diameter, volume, and protein content of H9c2 cells and promoted the phosphorylation of PI3K, Akt, ERK1/2, and p70S6K. Apelin-13 activated the PI3K-Akt-ERK1/2-p70S6K pathway. PI3K inhibitor LY294002, Akt inhibitor 1701-1, ERK1/2 inhibitor PD98059 attenuated the increase of the cell diameter, volume, protein content induced by apelin-13. Apelin-13 increased the autophagosomes and up-regulated the expressions of beclin 1 and LC3-II/I both transiently and stably. The autophagy inhibitor 3MA ameliorated the increase of cell diameter, volume, and protein content that were induced by apelin-13. These results suggested that apelin-13 promotes H9c2 rat cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy. PMID:26607438

  8. X-ray Rietveld refinement of structure of Ba-deficient Ba3Si6O12N2:Eu phosphor

    NASA Astrophysics Data System (ADS)

    Moriga, Toshihiro; Fujigaki, Hiroshi; Ogita, Yuma; Muguruma, Issei; Bando, Fumika; Murai, Kei-Ichiro; Waterhouse, Geoffrey I. N.

    2015-03-01

    Green oxynitride phosphors Ba3Si6O12N2 were prepared with metallic ratio of Si/Ba = 3. It was found that the nonstoichiometric mixture at Si/Ba = 3 formed the Ba3Si6O12N2-type phase easier than the stoichiometric one at Si/Ba = 2 after it was fired at 1200°C for 5 h under a diluted hydrogen flow (5%H2-95%N2). The excess Si source led to a formation of SiO2 glass, which can act as a flux in case of formation of Ba3Si6O12N2.

  9. 5-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethyl-perhydro-3,12-ep-oxy-1,2-dioxepino[4,3-i]isochromen-10-yl]oxymeth-yl}benzene-1,3-diol.

    PubMed

    Gul, Waseem; Carvalho, Paulo; Galal, Ahmed; Avery, Mitchell A; El Sohly, Mahmoud A

    2009-01-01

    The title compound, C(22)H(30)O(7), is a fused five-ring system that is of inter-est for its anti-cancer and anti-malarial activity. The six-membered C(6) and C(5)O rings display chair conformations. The six-membered C(3)O(3) ring containing the ether and per-oxy functionalities has a distorted boat conformation, with a C-O-O-C torsion angle of 42.6 (1)° for the per-oxy group. The seven-membered C(6)O ring has a distorted boat-type conformation, while the seven-membered C(5)O(2) ring has a very distorted chair-type conformation. The structure contains inter-molecular O-H⋯O and O-H⋯(O,O) bonds that link the mol-ecules into sheets parallel to the (100) planes. PMID:21581957

  10. Niobium alcoholate clusters with an octahedral arrangement of metal atoms: [K(CH3OH)4]2 [Nb6(OCH3)18] and [Na([18]crown-6)(C2H5OH)2]2 [Nb6(OC2H5)12(NCS)6].

    PubMed

    Flemming, Anke; Köckerling, Martin

    2009-01-01

    Complete exchange: [M(6)X(12)] type cluster compounds with an octahedral M(6) metal atom arrangement, which is completely surrounded by alcoholato ligands, were unknown until now. The first representatives are prepared containing a [Nb(6)(OR)(12)](4+) unit (R = CH(3) or C(2)H(5)). They are accessible at elevated temperatures from strongly basic alcoholate solutions of [Nb(6)Cl(12)](2+)-containing precursors. C gray, H white, K turquoise, Nb blue, O red.

  11. Bioactive 7-Oxabicyclic[6.3.0]lactam and 12-Membered Macrolides from a Gorgonian-Derived Cladosporium sp. Fungus

    PubMed Central

    Cao, Fei; Yang, Qin; Shao, Chang-Lun; Kong, Chui-Jian; Zheng, Juan-Juan; Liu, Yun-Feng; Wang, Chang-Yun

    2015-01-01

    One new bicyclic lactam, cladosporilactam A (1), and six known 12-membered macrolides (2–7) were isolated from a gorgonian-derived Cladosporium sp. fungus collected from the South China Sea. Their complete structural assignments were elucidated by comprehensive spectroscopic investigation. Quantum chemistry calculations were used in support of the structural determination of 1. The absolute configuration of 1 was determined by calculation of its optical rotation. Cladosporilactam A (1) was the first example of 7-oxabicyclic[6.3.0]lactam obtained from a natural source. Compound 1 exhibited promising cytotoxic activity against cervical cancer HeLa cell line with an IC50 value of 0.76 μM. PMID:26198234

  12. Bioactive 7-Oxabicyclic[6.3.0]lactam and 12-Membered Macrolides from a Gorgonian-Derived Cladosporium sp. Fungus.

    PubMed

    Cao, Fei; Yang, Qin; Shao, Chang-Lun; Kong, Chui-Jian; Zheng, Juan-Juan; Liu, Yun-Feng; Wang, Chang-Yun

    2015-07-01

    One new bicyclic lactam, cladosporilactam A (1), and six known 12-membered macrolides (2-7) were isolated from a gorgonian-derived Cladosporium sp. fungus collected from the South China Sea. Their complete structural assignments were elucidated by comprehensive spectroscopic investigation. Quantum chemistry calculations were used in support of the structural determination of 1. The absolute configuration of 1 was determined by calculation of its optical rotation. Cladosporilactam A (1) was the first example of 7-oxabicyclic[6.3.0]lactam obtained from a natural source. Compound 1 exhibited promising cytotoxic activity against cervical cancer HeLa cell line with an IC50 value of 0.76 μM.

  13. Solid-state conversion of (94-x)(Na1/2Bi1/2)TiO3-6BaTiO3-x(K1/2Na1/2)NbO3 single crystals and their enhanced converse piezoelectric properties

    NASA Astrophysics Data System (ADS)

    Park, Ji-Hoon; Kang, Suk-Joong L.

    2016-01-01

    (94-x)(Na1/2Bi1/2)TiO3-6BaTiO3-x(K1/2Na1/2)NbO3 (NBT-6BT-xKNN) piezoelectric ceramics have notable potential for replacing lead containing piezoelectric ceramics in actuator applications due to their exceptionally large strain. However, a high electric field for producing a large strain and a large hysteresis are critical issues that should be resolved for practical actuator applications. In an attempt to address these issues and optimize the piezoelectric performance, we fabricated NBT-6BT-xKNN (x = 0 - 5) piezoelectric single crystals with a size of 8 x 8x 10 mm by the solid-state single crystal growth method and systematically measured their electrical properties. With increased addition of KNN to replace NBT, the ferroelectricity and piezoelectricity of the fabricated [001] NBT-6BT-xKNN single crystals decreased, but their unipolar strain and hysteresis were considerably improved. For NBT-6BT-5KNN single crystals, the largest maximum strain (Smax) was 0.57% at 6 kV/mm, showing a converse piezoelectric constant (Smax/Emax) of 950 pm/V, and their hysteresis in the unipolar S-E curve was 12% at 6kV/mm, which would be appropriate for some actuator applications. Our results demonstrate the applicability of the produced single crystals as lead-free piezoelectric actuator components.

  14. Multiphoton ionization studies of clusters of immiscible liquids. II. C6H6- (H2O)n, n=3-8 and (C6H6)2- (H2O)1,2

    NASA Astrophysics Data System (ADS)

    Garrett, Aaron W.; Zwier, Timothy S.

    1992-03-01

    Resonant two-photon ionization (R2PI) time-of-flight mass spectroscopy is used to record S0-S1 spectra of the neutral complexes C6H6-(H2O)n with n=3-8 and (C6H6)2-(H2O)1,2. Due to limitations imposed by the size of these clusters, a number of vibronic level arguments are used to constrain the gross features of the geometries of these clusters. Among the spectral clues provided by the data are the frequency shifts of the transitions, their van der Waals structure, the fragmentation of the photoionized clusters, and the complexation-induced origin intensity and 610 splitting. In the 1:3 cluster, simple arguments are made based on the known structures of the 1:1 and 1:2 clusters which lead to the conclusion that all three water molecules reside on the same side of the benzene ring. Three structures for the 1:3 cluster are proposed which are consistent with the available data. Of these, only one is also consistent with the remarkable similarity of the 1:4 and 1:5 spectra to those of the 1:3 cluster. This structure involves a cyclic water trimer in which one of the water molecules is near the sixfold axis in a π hydrogen-bonded configuration. This structure is then expanded in the 1:4 and 1:5 clusters to incorporate the fourth and fifth water molecules in cyclic structures which place the additional water molecules far from the benzene ring without disturbing the interaction of the other water molecules with the benzene ring. For 1:n clusters with n≥6, subtle and then significant changes are observed in the spectra which indicate changes in the way the water cluster interacts with the benzene ring. This development occurs at precisely the water cluster size which calculations predict that cagelike water cluster structures will begin to compete and eventually be favored over large cyclic structures. Finally, cursory scans of the 2:1 cluster show that this cluster also fragments efficiently upon photoionization by loss of a single water molecule and that it possesses a

  15. Mineralogical studies of the nitrate deposits of Chile: VII. Two new saline minerals with the composition K6(Na,K)4Na6Mg10 (XO4) 12(IO3)12.12H2O: fuenzalidaite (X = S) and carlosruizite (X = Se)

    USGS Publications Warehouse

    Konnert, J.A.; Evans, H.T.; McGee, J.J.; Ericksen, G.E.

    1994-01-01

    Two new isostructural saline minerals from the nitrate deposits of northern Chile have the composition K6(Na,K)4Na6Mg10(XO4)12(IO3)12.12H2O: fuenzalidaite (X = S) and carlosruizite (X = Se,S,Cr). -from Authors

  16. Electron-impact excitation of the Rb 7 2S1/2, 8 2S1/2, 5 2D3/2, and 6 2D3/2 states

    NASA Astrophysics Data System (ADS)

    Wei, Zuyi; Flynn, Connor; Redd, Aaron; Stumpf, Bernhard

    1993-03-01

    Electron-impact cross sections for excitation of the 7 2S1/2, 8 2S1/2, 5 2D3/2, and 6 2D3/2 states of rubidium have been measured from threshold to 1000 eV. The optical-excitation-function method has been employed in a crossed atom- and electron-beam apparatus. Relative, total (cascade including) experimental cross sections are made absolute by comparison with the known total cross section of the Rb D1 line. Total excitation cross sections are compared with theoretical calculations employing first Born approximation and theoretical branching ratios. Born cross sections for the 7 2S1/2 and 8 2S1/2 states are obtained from the literature, while Born cross sections for the 5 2D3/2, 6 2D3/2, and all cascading states are calculated in this paper. At high energies, the measured total 2D3/2 state cross sections show 1/E behavior and converge to first Born theory; for E>100 eV, experiment and theory agree within 6.7% for 5 2D3/2 and within 3.7% for 6 2D3/2. The total cross sections for the 2S1/2 states do not converge to Born theory even at 1000 eV, and it is shown that this cannot be attributed to cascading. At low energies, 2S1/2 and 2D3/2 state total excitation cross sections have similar shapes with sharply peaked maxima at about 0.9 eV above threshold. After cascading is corrected using first Born theory, estimated experimental cross sections for direct excitation of higher fine-structure states of rubidium are given.

  17. K{sub 3}YB{sub 6}O{sub 12}: A new nonlinear optical crystal with a short UV cutoff edge

    SciTech Connect

    Zhao, Sangen; Zhang, Guochun; Yao, Jiyong; Wu, Yicheng

    2012-11-15

    Graphical abstract: Display Omitted Highlights: ► A new non-centrosymmetric borate, K{sub 3}YB{sub 6}O{sub 12}, has been synthesized. ► A K{sub 3}YB{sub 6}O{sub 12} crystal with dimensions of ∼40 mm × 30 mm × 10 mm was successfully grown. ► K{sub 3}YB{sub 6}O{sub 12} exhibits a short UV cutoff edge at 195 nm. ► Powder SHG effect of K{sub 3}YB{sub 6}O{sub 12} is weaker than that of KH{sub 2}PO{sub 4} (KDP). -- Abstract: A new non-centrosymmetric borate, K{sub 3}YB{sub 6}O{sub 12}, has been synthesized by solid state reaction techniques, and a K{sub 3}YB{sub 6}O{sub 12} crystal with dimensions of ∼40 mm × 30 mm × 10 mm was successfully grown by the top-seeded solution growth method using a K{sub 2}O–B{sub 2}O{sub 3}–KBF{sub 4} flux. K{sub 3}YB{sub 6}O{sub 12} crystallizes in the trigonal space group R32 with cell parameters of a = 13.2202(19) Å, c = 30.281(6) Å, and Z = 15. In the structure of K{sub 3}YB{sub 6}O{sub 12}, B{sub 5}O{sub 10} groups are bridged by Y{sub 3}O{sub 12} chains and discrete YO{sub 6} octahedra via corner-sharing, constructing columns packed side by side in a hexagonal motif along the c-axis to form a three-dimensional framework. The three-dimensional framework affords one-dimensional tunnels of 8-membered rings along the b-axis which are occupied by K atoms. K{sub 3}YB{sub 6}O{sub 12} melts incongruently at 941 °C, and exhibits a short UV cutoff edge at 195 nm. The second harmonic generation effect of K{sub 3}YB{sub 6}O{sub 12} is weaker than that of KH{sub 2}PO{sub 4}.

  18. Dating of groundwater using anthropogenic gaseous tracers (SF6, SF5CF3, CFC-12, HC-1311): methodological aspects

    NASA Astrophysics Data System (ADS)

    Bartyzel, J.; Rosiek, J.; Śliwka, I.; Rozanski, K.

    2012-04-01

    Groundwater is an important source of potable water in many countries. Nowadays, this strategic resource is at risk due to anthropogenic pollutants of various nature entering shallow aquifers. Proper management of groundwater resources requires precise understanding of groundwater dynamics on time scales characteristic for the history of pollutant input to groundwater. Several anthropogenic trace substances present in the atmosphere, such as freons (CFC-11, CFC-12) and sulfur hexafluoride (SF6) play an increasingly important role as environmental tracers allowing a better insight into the dynamic of groundwater systems. The concentration of SF6 in the atmosphere is increasing steadily, with the growth rate in the order of 5% per year. Recently, a new trace gas (trifluoromethyl sulphur pentafluoride - SF5CF3) has been discovered in the atmosphere. The atmospheric concentrations of SF5CF3 reconstructed from archive air samples have been increasing during the late 1980s and 1990s with the growth of ca. 6 % per year, with the sings of leveling-off during the last decade. We present here a dedicated analytical system capable to determine environmental levels of several gaseous tracers (SF6, SF5CF3, CFC-12, HC-1311) in air and water, with the precision and accuracy sufficiently low do use them for groundwater dating. In addition, the system is capable to measure in the same water sample the concentrations of Ne and Ar. This allows corrections for excess air to be made and the calculations of recharge temperatures. The field sampling system is based on a dynamic head-space method. The analysed water is pumped continuously through the extraction system where the dynamic head-space is created. Approximately 100 liters of water has to be pumped through the system before the dynamic equilibrium is reached in the head-space volume. Then, gaseous sample is collected from the head-space volume (ca. 200 ml) and transferred to the laboratory. The mixing ratio measurements are

  19. Volumetric Properties of the Mixture Propenenitrile C3H3N + C6H12O2 Butyl ethanoate (VMSD1111, LB4253_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Propenenitrile C3H3N + C6H12O2 Butyl ethanoate (VMSD1111, LB4253_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  20. Volumetric Properties of the Mixture Propenenitrile C3H3N + C6H12O2 Butyl ethanoate (VMSD1412, LB4272_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Propenenitrile C3H3N + C6H12O2 Butyl ethanoate (VMSD1412, LB4272_V)' providing data by calculation of isentropic compressibility from low-pressure density and thermodynamic speed of sound data at variable mole fraction and constant temperature, in the single-phase region(s).

  1. Volumetric Properties of the Mixture Propenenitrile C3H3N + C6H12O2 Butyl ethanoate (VMSD1212, LB4260_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Propenenitrile C3H3N + C6H12O2 Butyl ethanoate (VMSD1212, LB4260_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  2. Volumetric Properties of the Mixture Propenenitrile C3H3N + C6H12O2 Butyl ethanoate (VMSD1511, LB4266_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Propenenitrile C3H3N + C6H12O2 Butyl ethanoate (VMSD1511, LB4266_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  3. Treatment of intracerebral hemorrhage in rats with 12 h, 3 days and 6 days of selective brain hypothermia.

    PubMed

    Fingas, Matthew; Penner, Mark; Silasi, Gergely; Colbourne, Frederick

    2009-09-01

    Intracerebral hemorrhage (ICH) is a devastating stroke with no proven treatment to reduce brain injury. In this study we modeled ICH by injecting 100 microL of autologous blood into the striatum of rats. We then tested whether hypothermia would reduce brain injury and improve recovery as has been repeatedly observed for ischemic and traumatic brain damage. Aside from reducing blood-brain barrier disruption, inflammation and edema, hypothermia has not consistently improved behavioral or histological outcome after ICH in animal studies. As this might relate to the choice of cooling method and the duration of hypothermia, we used a system that selectively cooled the injured hemisphere to approximately 32 degrees C (striatum) while the body remained normothermic. Cooling (vs. normothermia) started 1 h after ICH and lasted for 12 h, 3 days or 6 days followed by slow re-warming (approximately 1 degrees C/h). Functional impairment was evaluated from 2 to 3 weeks post-ICH at which time brain injury was determined. The ICH caused significant impairment on a neurological deficit scale and in tests of walking (horizontal ladder), skilled reaching (tray task) and spontaneous limb usage (cylinder test). Only the limb use asymmetry deficit was significantly mitigated by hypothermia, and then only by the longest treatment. Lesion volume, which averaged 16.9 mm3, was not affected. These results, in conjunction with earlier studies, suggest that prolonged mild hypothermia will not be a profound neuroprotectant for patients with striatal ICH, but it may nonetheless improve functional recovery in addition to its use for treating cerebral edema. PMID:19445934

  4. 46 CFR 12.01-6-12.01-7 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false 12.01-6-12.01-7 Section 12.01-6-12.01-7 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN REQUIREMENTS FOR RATING ENDORSEMENTS General §§ 12.01-6-12.01-7...

  5. Synthesis and structural characterisation of new ettringite and thaumasite type phases: Ca6[Ga(OH)6·12H2O]2(SO4)3·2H2O and Ca6[M(OH)6·12H2O]2(SO4)2(CO3)2, M = Mn, Sn

    NASA Astrophysics Data System (ADS)

    Norman, Rachel L.; Dann, Sandra E.; Hogg, Simon C.; Kirk, Caroline A.

    2013-11-01

    Investigations into the formation of new ettringite-type phases with a range of trivalent and tetravalent cations were carried out to further study the potential this structure type has to incorporate cations covering a range of ionic radii (0.53-0.69 Å). We report the synthesis and structural characterisation of a new ettringite-type phase, Ca6[Ga(OH)6·12H2O]2(SO4)3·2H2O, which was indexed in space group P31c with the unit cell parameters a = 11.202(2) Å, c = 21.797(3) Å and two new thaumasite-type phases Ca6[M(OH)6·12H2O]2(SO4)2(CO3)2, M = Mn, Sn which were indexed in space group P63 with the unit cell parameters a = 11.071(5) Å, c = 21.156(8) Å and a = 11.066(1) Å, c = 22.420(1) Å respectively. These new phases show the versatility of the ettringite family of structures to tolerate a large range of cation sizes on the octahedral M site and highlights the preference of tetravalent cations to crystallise with the thaumasite structure over the ettringite structure.

  6. Concentration-Dominated Temperature-Dependence of Upconversion Luminescence in Gd6WO12 Nanophosphor Co-Doped with Er3+ and Yb3+.

    PubMed

    Zhang, Yanqiu; Chen, Baojiu; Li, Xiangping; Sun, Jiashi; Zhang, Jinsu; Zheng, Hui; Wu, Zhongli; Zhong, Hua; Hua, Ruinian; Xia, Haiping

    2016-04-01

    Nanosized Gd6WO12 phosphors containing various Er3+ concentrations and fixed Yb3+ concentration were synthesized by a co-precipitation method. The crystal structure and microscopic morphology of the obtained nanophosphors were characterized by means of X-ray diffraction (XRD) and field emission scanning electron microscopy (FE-SEM). Two-photon processes for both the green and red upconversion (UC) emissions were confirmed by analyzing the dependence of UC intensities on 980 nm laser working current. UC emission intensity changing with temperature displays different trends for the samples with different Er3+ concentrations. The experimental results indicated that thermal quenching behavior of UC luminescence could not be simply explained by crossover mechanism. The enhancement for green UC emission in the sample with higher Er3+ concentration was discussed. Finally, the ErS+ concentration dependence of UC luminescence was experimentally observed, and its mechanisms were analyzed. PMID:27451662

  7. Preparation in Acidic and Alkaline Conditions and Characterization of α-Bi2Mo3O12 and γ-Bi2MoO6 Powders

    NASA Astrophysics Data System (ADS)

    Chen, Tao; Wang, Mao-Hua; Ma, Xiao-Yu

    2016-08-01

    α-Bi2Mo3O12 and γ-Bi2MoO6 powders have been successfully fabricated via a sol-gel method starting from bismuth nitrate and ammonium molybdate. The as-synthesized samples were characterized by x-ray powder diffraction analysis, thermogravimetry and differential thermogravimetry, scanning electron microscopy, and ultraviolet-visible (UV-Vis) absorption spectroscopy. The results indicated the formation of α-Bi2Mo3O12 and γ-Bi2MoO6 powders in acidic (pH 5) and alkaline (pH 9) conditions, respectively. α-Bi2Mo3O12 exhibited irregular shape, while γ-Bi2MoO6 showed approximately flake-like morphology. The bandgap of pure α-Bi2Mo3O12 and γ-Bi2MoO6 was estimated to be about 2.83 eV and 2.85 eV, respectively, according to UV-Vis studies. The slight shift of the absorption edge towards longer wavelength for α-Bi2Mo3O12 indicated a decrease of the optical bandgap. Photocatalytic experiments showed that γ-Bi2MoO6 exhibited higher photodegradation activity of methylene blue compared with α-Bi2Mo3O12.

  8. 40 CFR 721.7280 - 1,3-Propanediamine, N,N′-1,2-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl...-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl-4..., reaction products with N-butyl-2,2,6,6-tetramethyl-4-piperidinamine (PMN P-89-632) is subject to...

  9. 40 CFR 721.7280 - 1,3-Propanediamine, N,N′-1,2-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl...-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl-4..., reaction products with N-butyl-2,2,6,6-tetramethyl-4-piperidinamine (PMN P-89-632) is subject to...

  10. 40 CFR 721.7280 - 1,3-Propanediamine, N,N′-1,2-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl...-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl-4..., reaction products with N-butyl-2,2,6,6-tetramethyl-4-piperidinamine (PMN P-89-632) is subject to...

  11. 40 CFR 721.7280 - 1,3-Propanediamine, N,N′-1,2-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl...-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl-4..., reaction products with N-butyl-2,2,6,6-tetramethyl-4-piperidinamine (PMN P-89-632) is subject to...

  12. 40 CFR 721.7280 - 1,3-Propanediamine, N,N′-1,2-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...-ethanediylbis-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl...-, polymer with 2,4,6-trichloro-1,3,5-triazine, reaction products with N-butyl-2,2,6,6-tetramethyl-4..., reaction products with N-butyl-2,2,6,6-tetramethyl-4-piperidinamine (PMN P-89-632) is subject to...

  13. Salt-inclusion synthesis of two new polar solids, Ba6Mn4Si12O34Cl3 and Ba6Fe5Si11O34Cl3.

    PubMed

    Mo, Xunhua; Ferguson, Erin; Hwu, Shiou-Jyh

    2005-05-01

    A new family of salt-containing, mixed-metal silicates (CU-14), Ba6Mn4Si12O34Cl3 (1) and Ba6Fe5Si11O34Cl3 (2), was synthesized via the BaCl2 salt-inclusion reaction. These compounds crystallize in the noncentrosymmetric (NCS) space group Pmc2(1) (No. 26), adopting 1 of the 10 NCS polar, nonchiral crystal classes, mm2 (C2v). The cell dimensions are a = 6.821(1) A, b = 9.620(2) A, c = 13.172(3) A, and V = 864.4(3) A3 for 1 and a = 6.878(1) A, b = 9.664(2) A, c = 13.098(3) A, and V = 870.6(3) A3 for 2. The structures form a composite framework made of the (M(4+x)Si(12-x)O34)9- (M = Mn, x = 0; M = Fe, x = 1) covalent oxide and (Ba6Cl3)9+ ionic chloride sublattices. The covalent framework exhibits a pseudo-one-dimensional channel where the extended barium chloride lattice (Ba3Cl1.5)(infinity) resides, and it consists of fused eight-membered meta-silicate rings propagating along [100] via sharing two opposite [Si2O7]6- units to form an acentric lattice. Single-crystal structure studies also reveal the ClBa4 unit adopting an interesting seesaw configuration, in which the lone pair electrons of chlorine preferentially face the oxide anions of the transition metal silicate channel, thus forming the observed polar frameworks. Similar to the synthesis of organic-inorganic hybrid materials, the salt-inclusion method facilitates a promising approach for the directed synthesis of special framework solids, including NCS compounds, via composite lattices. PMID:15847417

  14. Reversible addition of water to the high-hydride-content cluster [Rh6(PiPr3)6H12][BArF4]2. Synthesis and Structure of [Rh6PiPr3)6H11(OH)][BArF4]2.

    PubMed

    Douglas, Thomas M; Brayshaw, Simon K; Raithby, Paul R; Weller, Andrew S

    2008-02-01

    The hydroxyhydrido salt [Rh(6)(P(i)Pr(3))(6)H(11)(OH)][BArF(4)](2) results from the addition of water to [Rh(6)(P(i)Pr(3))(6)H(12)][BArF(4)](2). This reaction is reversible, and the addition of dihydrogen to [Rh(6)(P(i)Pr(3))(6)H(11)(OH)][BArF(4)](2) results in the elimination of water and the regeneration of the hydride cluster. PMID:18181618

  15. Dating groundwater with trifluoromethyl sulfurpentafluoride (SF 5CF3), sulfur hexafluoride (SF6), CF 3Cl (CFC-13), and CF2Cl2 (CFC-12)

    USGS Publications Warehouse

    Busenberg, E.; Plummer, L.N.

    2008-01-01

    [1] A new groundwater dating procedure using the transient atmospheric signal of the environmental tracers SF5CF3, CFC-13, SF6, and CFC-12 was developed. The analytical procedure determines concentrations of the four tracers in air and water samples. SF 5CF3 and CFC-13 can be used to date groundwaters in some environments where the CFCs and SF6 have previously failed because these new tracers have increasing atmospheric input functions, no known terrigenic source, and are believed to be stable under reducing conditions. SF5CF3 has a dating range from 1970 to modern; the mixing ratio (mole fraction) in North American air has increased from the detection limit of 0.005 parts per trillion (ppt) to the 2006 mole fraction of about 0.16 ppt. No evidence was found for degradation of SF5CF3 in laboratory anaerobic systems. The solubility of SF5CF3 was measured in water from 1 to 35??C. Groundwater samples that contained large amounts of terrigenic SF6 did not contain terrigenic SF 5CF3. CFC-13 is a trace atmospheric gas with a dating range in groundwater of about 1965 to modem. CFC-13 has been used primarily in very low-temperature refrigeration; thus groundwater environments are less likely to be contaminated with nonatmospheric sources as compared to other widely used CFCs. Because of the low solubility of SF5CF3 and CFC-13 in water, an excess air correction must be applied to the apparent ages. The new dating procedure was tested in water samples from wells and springs from Maryland, Virginia, and West Virginia.

  16. Modified kagome physics in the natural spin-1/2 kagome lattice systems: kapellasite Cu3Zn(OH)6Cl2 and haydeeite Cu3Mg(OH)6Cl2.

    PubMed

    Janson, O; Richter, J; Rosner, H

    2008-09-01

    The recently discovered natural minerals Cu3Zn(OH)6Cl2 and Cu3Mg(OH)6Cl2 are spin 1/2 systems with an ideal kagome geometry. Based on electronic structure calculations, we develop a realistic model which includes couplings across the kagome hexagons beyond the original kagome model that are intrinsic in real kagome materials. Exact diagonalization studies for the derived model reveal a strong impact of these couplings on the magnetic ground state. Our predictions could be compared to and supplied with neutron scattering, thermodynamic data, and NMR data.

  17. Subchronic toxicity study of 3-monochloropropane-1,2-diol administered by drinking water to B6C3F1 mice.

    PubMed

    Cho, Wan-Seob; Han, Beom Seok; Lee, Hakyung; Kim, Cheulkyu; Nam, Ki Taek; Park, Kidae; Choi, Mina; Kim, Sung Jun; Kim, Seung Hee; Jeong, Jayoung; Jang, Dong Deuk

    2008-05-01

    3-Monochloropropane-1,2-diol (3-MCPD) is a food processing contaminant in a wide range of foods and ingredients and is a suspected cause of cancer. In this study, the 13-week toxicity of 3-MCPD was examined in B6C3F1 mice (10/sex/group) administered 3-MCPD doses of 0, 5, 25, 100, 200 and 400 ppm dissolved in their drinking water over a 13-week period. All the mice survived to the end of study. The mean body weight gains in the males and females given 400 ppm were significantly lower than those of the controls. The relative kidney weights of the males and females given 200 and 400 ppm were significantly higher than those of the controls without any corresponding histopathological changes. The sperm motility was lower in the 400 ppm group than the control, and there was a significant increase in the incidence of germinal epithelium degeneration in the 200 and 400 ppm groups. A delayed total estrus cycle length was observed in the 400 ppm group without any histopathological changes. Based on these results, the target organ was determined to be kidney, testis, and ovary. The no-observed-adverse-effect level (NOAEL) was found to be 100 ppm (18.05 mg/kg/day for males and 15.02 mg/kg/day for females).

  18. Development of HPLC Chiral Stationary Phases Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid and Their Applications.

    PubMed

    Hyun, Myung Ho

    2015-09-01

    Crown ether-based chiral stationary phases (CSPs) have been known to be useful for the resolution of racemic primary amino compounds. In particular, CSPs based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid have been reported to be useful for the resolution of secondary amino compounds as well as primary amino compounds. In this article, the process of developing various CSPs based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid to improve the chiral recognition efficiency and/or the stability of the CSPs and their applications to the resolution of various primary and nonprimary amino compounds are reviewed.

  19. Development of HPLC Chiral Stationary Phases Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid and Their Applications.

    PubMed

    Hyun, Myung Ho

    2015-09-01

    Crown ether-based chiral stationary phases (CSPs) have been known to be useful for the resolution of racemic primary amino compounds. In particular, CSPs based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid have been reported to be useful for the resolution of secondary amino compounds as well as primary amino compounds. In this article, the process of developing various CSPs based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid to improve the chiral recognition efficiency and/or the stability of the CSPs and their applications to the resolution of various primary and nonprimary amino compounds are reviewed. PMID:26237013

  20. Symmetry reduction due to gallium substitution in the garnet Li6.43(2)Ga0.52(3)La2.67(4)Zr2O12

    PubMed Central

    Robben, Lars; Merzlyakova, Elena; Heitjans, Paul; Gesing, Thorsten M.

    2016-01-01

    Single-crystal structure refinements on lithium lanthanum zirconate (LLZO; Li7La3Zr2O12) substituted with gallium were successfully carried out in the cubic symmetry space group I 3d. Gallium was found on two lithium sites as well as on the lanthanum position. Due to the structural distortion of the resulting Li6.43(2)Ga0.52(3)La2.67(4)Zr2O12 (Ga–LLZO) single crystals, a reduction of the LLZO cubic garnet symmetry from Ia d to I 3d was necessary, which could hardly be analysed from X-ray powder diffraction data. PMID:27006788

  1. (C5H6N)4[Be6(HPO3)8]·H2O: A low-density open-framework beryllium phosphite with multidirectional 12-ring channels

    NASA Astrophysics Data System (ADS)

    Wang, Guo-Ming; Li, Jin-Hua; Zhang, Xiao; Jiang, Wen-Wen; Bao, Zhen-Zhen; Zhao, Xiao-Meng; Wang, Ying-Xia; Lin, Jian-Hua

    2014-07-01

    Employing the common pyridine (=py) solvent as the source of structure-directing agents (SDAs), a novel three-dimensional open-framework beryllium phosphite (Hpy)4[Be6(HPO3)8]·H2O (1), has been solvothermally synthesized and structurally characterized by IR, elemental analysis, thermogravimetric analysis, powder and single-crystal X-ray diffractions. It crystallizes in the orthorhombic system, space group Pbca (No. 61), a = 20.0034(4) Å, b = 20.2188(4) Å, c = 20.9731(3) Å, V = 8482.5(3) Å3, and Z = 8. The alternating connection of BeO4 tetrahedra and HPO3 pseudopyramids give rise to a (3, 4)-connected network with multidirectional intersecting 12-ring channels. The compound possesses a low density and a new {4.8.10}{42.6.8.10.12}{42.6}3{42.8.102.12}{43.62.8} topology.

  2. Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling

    PubMed Central

    Qu, Zhaoxia

    2016-01-01

    The human oncogenic virus Kaposi's sarcoma herpesvirus (KSHV) is the most common cause of malignancies among AIDS patients. KSHV possesses over hundred genes, including 25 microRNAs (miRNAs). The roles of these miRNAs and many other viral genes in KSHV biology and pathogenesis remain largely unknown. Accordingly, the molecular mechanisms by which KSHV induces tumorigenesis are still poorly defined. Here, we identify KSHV miRNA K12-1 (miR-K12-1) as a novel viral oncogene by activating two important transcription factors, nuclear factor-κb (NF-κB) and signal transducer and activator of transcription 3 (STAT3). Interestingly, miR-K12-1 activates STAT3 indirectly through inducing NF-κB activation and NF-κB-dependent expression of the cytokine interleukin-6 (IL-6) by repressing the expression of the NF-κB inhibitor IκBα. Accordingly, expression of ectopic IκBα or knockdown of NF-κB RelA, IL-6 or STAT3 prevents expression of cell growth genes and suppresses the oncogenicities of both miR-K12-1 and KSHV. These data identify miR-K12-1/NF-κB/IL-6/STAT3 as a novel oncogenic signaling underlying KSHV tumorigenesis. These data also provide the first evidence showing that IL-6/STAT3 signaling acts as an essential mediator of NF-κB oncogenic actions. These findings significantly improve our understanding of KSHV pathogenesis and oncogenic interaction between NF-κB and STAT3. PMID:27166260

  3. 40 CFR 721.5400 - 3,6,9,12,15,18,21-Hepta-oxa-tetra-triaoctanoic acid, sodium salt.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...-triaoctanoic acid, sodium salt. 721.5400 Section 721.5400 Protection of Environment ENVIRONMENTAL PROTECTION... acid, sodium salt. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as 3,6,9,12,15,18,21-hep-ta-oxa-te-tra-tri-aocta-noic acid, sodium salt...

  4. The Role of Morphology and Short Vowelization in Reading Arabic among Normal and Dyslexic Readers in Grades 3, 6, 9, and 12

    ERIC Educational Resources Information Center

    Abu-Rabia, Salim

    2007-01-01

    This study was an investigation of several Arabic reading measures among dyslexics and normal Arabic readers across different ages (grades 3, 6, 9, and 12): the role of morphology, short vowelization (phonological and syntactic skills), spelling, reading isolated words, and reading comprehension. The results of the one-way ANOVAs indicated clear…

  5. Experimental measurement of the van der Waals binding energy of X-O{sub 2} clusters (X=Xe,CH{sub 3}I,C{sub 3}H{sub 6},C{sub 6}H{sub 12})

    SciTech Connect

    Vidma, Konstantin V.; Bogdanchikov, Georgii A.; Baklanov, Alexey V.; Chestakov, Dmitri A.; Parker, David H.

    2010-11-21

    Van der Waals binding energies for the X-O{sub 2} complexes (X=Xe,CH{sub 3}I,C{sub 3}H{sub 6},C{sub 6}H{sub 12}) are determined by analysis of experimental velocity map imaging data for O({sup 3}P{sub 2}) atoms arising from UV-photodissociation of the complex [A. V. Baklanov et al., J. Chem. Phys. 126, 124316 (2007)]. Several dissociation pathways have been observed, we focus on the channel corresponding to prompt dissociation of X-O{sub 2} into X+2O({sup 3}P) fragments, which is present for complexes of O{sub 2} with all partners X. Our method is based on analysis of the kinetic energy of all three photofragments, where the O atom kinetic energy was directly measured in the experiment and the kinetic energy of the X partner was calculated using momentum conservation, along with the measured angular anisotropy for O atom recoil. We exploit the fact that the clusters are all T-shaped or nearly T-shaped, which we also confirm by ab initio calculations, along with knowledge of the transition dipole governing radiative absorption by the complex. The effect of partitioning the kinetic energy between translation along the X-O{sub 2} and O-O coordinates on the angular anisotropy of the O atom recoil direction is discussed. Van der Waals binding energies of 110{+-}20 cm{sup -1}, 280{+-}20 cm{sup -1}, 135{+-}30 cm{sup -1}, and 585{+-}20 cm{sup -1} are determined for Xe-O{sub 2}, CH{sub 3}I-O{sub 2}, C{sub 3}H{sub 6}-O{sub 2}, and C{sub 6}H{sub 12}-O{sub 2} clusters, respectively.

  6. Thermally stable compositions including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt

    DOEpatents

    Hiskey, Michael A.; Huynh, My Hang

    2010-01-26

    An explosive formulation including 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt and a high temperature binder is disclosed together with a process of preparing 2,4,8,10-tetranitro-5H-pyrido[3',2':4,5][1,2,3]triazolo[1,2-a]benzotriazo- l-6-ium, inner salt.

  7. Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis.

    PubMed

    Lazic, Milos; Inzaugarat, Maria Eugenia; Povero, Davide; Zhao, Iris C; Chen, Mark; Nalbandian, Madlena; Miller, Yury I; Cherñavsky, Alejandra C; Feldstein, Ariel E; Sears, Dorothy D

    2014-01-01

    Obesity is associated with metabolic perturbations including liver and adipose tissue inflammation, insulin resistance, and type 2 diabetes. Omega-6 fatty acids (ω6) promote and omega-3 fatty acids (ω3) reduce inflammation as they can be metabolized to pro- and anti-inflammatory eicosanoids, respectively. 12/15-lipoxygenase (12/15-LO) enzymatically produces some of these metabolites and is induced by high fat (HF) diet. We investigated the effects of altering dietary ω63 ratio and 12/15-LO deficiency on HF diet-induced tissue inflammation and insulin resistance. We examined how these conditions affect circulating concentrations of oxidized metabolites of ω6 arachidonic and linoleic acids and innate and adaptive immune system activity in the liver. For 15 weeks, wild-type (WT) mice were fed either a soybean oil-enriched HF diet with high dietary ω63 ratio (11∶1, HFH), similar to Western-style diet, or a fat Kcal-matched, fish oil-enriched HF diet with a low dietary ω63 ratio of 2.7∶1 (HFL). Importantly, the total saturated, monounsaturated and polyunsaturated fat content was matched in the two HF diets, which is unlike most published fish oil studies in mice. Despite modestly increased food intake, WT mice fed HFL were protected from HFH-diet induced steatohepatitis, evidenced by decreased hepatic mRNA expression of pro-inflammatory genes and genes involved in lymphocyte homing, and reduced deposition of hepatic triglyceride. Furthermore, oxidized metabolites of ω6 arachidonic acid were decreased in the plasma of WT HFL compared to WT HFH-fed mice. 12/15-LO knockout (KO) mice were also protected from HFH-induced fatty liver and elevated mRNA markers of inflammation and lymphocyte homing. 12/15-LOKO mice were protected from HFH-induced insulin resistance but reducing dietary ω63 ratio in WT mice did not ameliorate insulin resistance or adipose tissue inflammation. In conclusion, lowering dietary ω63 ratio in HF diet significantly reduces

  8. Upper bounds on ɛ'/ ɛ parameters B 6 (1/2) and B 8 (3/2) from large N QCD and other news

    NASA Astrophysics Data System (ADS)

    Buras, Andrzej J.; Gérard, Jean-Marc

    2015-12-01

    We demonstrate that in the large N approach developed by the authors in collaboration with Bardeen, the parameters B 6 (1/2) and B 8 (3/2) parametrizing the K → ππ matrix elements < Q 6>0 and < Q 8>2 of the dominant QCD and electroweak operators receive both negative O(1/N) corrections such that B 6 (1/2) ≤ B 8 (3/2) < 1 in agreement with the recent lattice results of the RBC-UKQCD collaboration. We also point out that the pattern of the size of the hadronic matrix elements of all QCD and electroweak penguin operators Q i contributing to the K → ππ amplitudes A 0 and A 2, obtained by this lattice collaboration, provides further support to our large N approach. In particular, the lattice result for the matrix element < Q 8>0 implies for the corresponding parameter B 8 (1/2) = 1.0 ± 0.2 to be compared with large N value B 8 (1/2) = 1.1 ± 0.1. We discuss briefly the implications of these findings for the ratio ɛ' /ɛ. In fact, with the precise value for B 8 (3/2) from RBC-UKQCD collaboration, our upper bound on B 6 (1/2) implies ɛ' /ɛ in the SM roughly by a factor of two below its experimental value (16 .6± 2 .3) × 10-4. We also briefly comment on the parameter {widehat{B}}_K and the Δ I = 1 /2 rule.

  9. Ru sub 3 (CO) sub 12 and Mo(CO) sub 6 adsorbed on Ru(001) and Au/Ru: An infrared reflection-absorption study

    SciTech Connect

    Malik, I.J.; Hrbek, J.

    1990-01-01

    We obtained IRAS and TDS data for Ru{sub 3}(CO){sub 12}/Ru(001) and Mo(CO){sub 6}/Au/Ru systems for metal carbonyl coverages between submonolayer and approximately 20 monolayers. We characterized the C-O stretching mode of both systems (4 cm{sup {minus}1} FWHM) and a deformation mode of Mo(CO){sub 6} at 608 cm{sup {minus}1} (1 cm{sup {minus}1} FWHM). Both IRAS and TDS data suggest adsorption and desorption of metal carbonyls as molecular species with a preferential orientation in the overlayers. The IR intensity of the C-O stretch per a C-O bond projected onto the surface normal is approximately twice (five times) larger for Ru{sub 3}(CO){sub 12} (Mo(CO){sub 6}) at submonolayer coverages than for CO/Ru(001) at {theta}{sub CO}=0.68. 31 refs., 4 figs.

  10. Transfer between the cesium 62P1/2 and 62P3/2 levels induced by collisions with H2, HD, D2, CH4, C2H6, CF4, and C2F6

    NASA Astrophysics Data System (ADS)

    Pitz, Greg A.; Fox, Charles D.; Perram, Glen P.

    2011-09-01

    The cross sections of spin-orbit energy exchange between the cesium 62P1/2↔62P3/2 states induced by collisions with N2, H2, HD, D2, CH4, C2H6, CF4, and C2F6 were obtained for pressures less than 100 Torr at room temperature by means of steady-state laser-induced fluorescence techniques. The spin-orbit energy exchange rate with N2, H2, HD, D2, CH4, C2H6, CF4, and C2F6, have been measured as σ21(62P3/2→62P1/2)= 16.3, 34.1, 30.0, 22.7, 21.4, 65.6, 64.8, and 137 Å2 and σ12(62P1/2→62P3/2)= 1.8, 4.4, 4.1, 3.0, 2.9, 13.3, 9.7, and 16.3 Å2, respectively. Correlations of the spin-orbit transfer probabilities with rotational-energy defect and vibrational-energy defect have been shown.

  11. Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice.

    PubMed

    Gi, Min; Fujioka, Masaki; Yamano, Shotaro; Shimomura, Eri; Ishii, Naomi; Kakehashi, Anna; Takeshita, Masanori; Wanibuchi, Hideki

    2015-05-01

    1,2-Dichloropropane (1,2-DCP) has recently been reclassified from not classifiable as to its carcinogenicity to humans (Group 3) to carcinogenic to humans (Group 1) by the International Agency for Research on Cancer. This was based on the findings of epidemiological studies in Japan that occupational exposure to paint stripers containing 1,2-DCP was associated with increased cholangiocarcinomas. It is known that 1,2-DCP is negative for cholangiocarcinogenicity in rats and mice. However, its toxicity and carcinogenicity has not been examined in hamsters and little is known about the regulation of its metabolism in hamsters. The purpose of this study was to determine the hepatobiliary toxicity of 1,2-DCP in hamsters and to characterize and compare the altered patterns of hepatic xenometabolic enzymes in hamsters and mice. Male Syrian hamsters and male B6C3F1 mice were treated with various doses of 1,2-DCP for 4 h or 3 days or 4 weeks. These experiments demonstrated that a high dose of 1,2-DCP induced centrilobular hepatocellular necrosis in hamsters. CYP2E1 is possibly the key enzyme responsible for bioactivation and the consequent hepatocytotoxicity of 1,2-DCP, and GSH conjugation catalyzed by GST-T1 may exert a cytoprotective role in hamsters and mice. Notably, the expression pattern of GST-T1 in bile duct epithelial cells differed between hamsters and mice: GST-T1 was expressed in bile duct epithelial cells of mice but not hamsters. This indicates that responses to 1,2-DCP in the bile duct of hamsters might differ from that of mice, and suggests that long-term studies are necessary to clarify the chalangiocarcinogenicity of 1,2-DCP in hamsters, though no biliary toxicity was observed in the present short-term experiments.

  12. Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice.

    PubMed

    Gi, Min; Fujioka, Masaki; Yamano, Shotaro; Shimomura, Eri; Ishii, Naomi; Kakehashi, Anna; Takeshita, Masanori; Wanibuchi, Hideki

    2015-05-01

    1,2-Dichloropropane (1,2-DCP) has recently been reclassified from not classifiable as to its carcinogenicity to humans (Group 3) to carcinogenic to humans (Group 1) by the International Agency for Research on Cancer. This was based on the findings of epidemiological studies in Japan that occupational exposure to paint stripers containing 1,2-DCP was associated with increased cholangiocarcinomas. It is known that 1,2-DCP is negative for cholangiocarcinogenicity in rats and mice. However, its toxicity and carcinogenicity has not been examined in hamsters and little is known about the regulation of its metabolism in hamsters. The purpose of this study was to determine the hepatobiliary toxicity of 1,2-DCP in hamsters and to characterize and compare the altered patterns of hepatic xenometabolic enzymes in hamsters and mice. Male Syrian hamsters and male B6C3F1 mice were treated with various doses of 1,2-DCP for 4 h or 3 days or 4 weeks. These experiments demonstrated that a high dose of 1,2-DCP induced centrilobular hepatocellular necrosis in hamsters. CYP2E1 is possibly the key enzyme responsible for bioactivation and the consequent hepatocytotoxicity of 1,2-DCP, and GSH conjugation catalyzed by GST-T1 may exert a cytoprotective role in hamsters and mice. Notably, the expression pattern of GST-T1 in bile duct epithelial cells differed between hamsters and mice: GST-T1 was expressed in bile duct epithelial cells of mice but not hamsters. This indicates that responses to 1,2-DCP in the bile duct of hamsters might differ from that of mice, and suggests that long-term studies are necessary to clarify the chalangiocarcinogenicity of 1,2-DCP in hamsters, though no biliary toxicity was observed in the present short-term experiments. PMID:25711234

  13. Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice

    PubMed Central

    Gi, Min; Fujioka, Masaki; Yamano, Shotaro; Shimomura, Eri; Ishii, Naomi; Kakehashi, Anna; Takeshita, Masanori; Wanibuchi, Hideki

    2015-01-01

    1,2-Dichloropropane (1,2-DCP) has recently been reclassified from not classifiable as to its carcinogenicity to humans (Group 3) to carcinogenic to humans (Group 1) by the International Agency for Research on Cancer. This was based on the findings of epidemiological studies in Japan that occupational exposure to paint stripers containing 1,2-DCP was associated with increased cholangiocarcinomas. It is known that 1,2-DCP is negative for cholangiocarcinogenicity in rats and mice. However, its toxicity and carcinogenicity has not been examined in hamsters and little is known about the regulation of its metabolism in hamsters. The purpose of this study was to determine the hepatobiliary toxicity of 1,2-DCP in hamsters and to characterize and compare the altered patterns of hepatic xenometabolic enzymes in hamsters and mice. Male Syrian hamsters and male B6C3F1 mice were treated with various doses of 1,2-DCP for 4 h or 3 days or 4 weeks. These experiments demonstrated that a high dose of 1,2-DCP induced centrilobular hepatocellular necrosis in hamsters. CYP2E1 is possibly the key enzyme responsible for bioactivation and the consequent hepatocytotoxicity of 1,2-DCP, and GSH conjugation catalyzed by GST-T1 may exert a cytoprotective role in hamsters and mice. Notably, the expression pattern of GST-T1 in bile duct epithelial cells differed between hamsters and mice: GST-T1 was expressed in bile duct epithelial cells of mice but not hamsters. This indicates that responses to 1,2-DCP in the bile duct of hamsters might differ from that of mice, and suggests that long-term studies are necessary to clarify the chalangiocarcinogenicity of 1,2-DCP in hamsters, though no biliary toxicity was observed in the present short-term experiments. PMID:25711234

  14. High-Temperature Thermoelectric Properties of the Solid–Solution Zintl Phase Eu11Cd6Sb12–xAsx (x < 3)

    SciTech Connect

    Kazem, Nasrin; Xie, Weiwei; Ohno, Saneyuki; Zevalkink, Alexandra; Miller, Gordon J; Snyder, G Jeffrey; Kauzlarich, Susan M

    2014-02-11

    Zintl phases are compounds that have shown promise for thermoelectric applications. The title solid–solution Zintl compounds were prepared from the elements as single crystals using a tin flux for compositions x = 0, 1, 2, and 3. Eu11Cd6Sb12–xAsx (x < 3) crystallize isostructurally in the centrosymmetric monoclinic space group C2/m (no. 12, Z = 2) as the Sr11Cd6Sb12 structure type (Pearson symbol mC58). Efforts to make the As compositions for x exceeding ~3 resulted in structures other than the Sr11Cd6Sb12 structure type. Single-crystal X-ray diffraction indicates that As does not randomly substitute for Sb in the structure but is site specific for each composition. The amount of As determined by structural refinement was verified by electron microprobe analysis. Electronic structures and energies calculated for various model structures of Eu11Cd6Sb10As2 (x = 2) indicated that the preferred As substitution pattern involves a mixture of three of the six pnicogen sites in the asymmetric unit. In addition, As substitution at the Pn4 site opens an energy gap at the Fermi level, whereas substitution at the other five pnicogen sites remains semimetallic with a pseudo gap. Thermoelectric properties of these compounds were measured on hot-pressed, fully densified pellets. Samples show exceptionally low lattice thermal conductivities from room temperature to 775 K: 0.78–0.49 W/mK for x = 0; 0.72–0.53 W/mK for x = 1; and 0.70–0.56 W/mK for x = 2. Eu11Cd6Sb12 shows a high p-type Seebeck coefficient (from +118 to 153 μ V/K) but also high electrical resistivity (6.8 to 12.8 mΩ·cm). The value of zT reaches 0.23 at 774 K. The properties of Eu11Cd6Sb12–xAsx are interpreted in discussion with the As site substitution.

  15. The ν4, ν9, ν10 and ν6+ν11 bands of 13CH3-12CH3 between 1245 and 1550 cm-1

    NASA Astrophysics Data System (ADS)

    Brown, Linda R.; di Lauro, C.; Lattanzi, F.; Mantz, A. W.; Smith, M. H.

    2013-10-01

    To support atmospheric studies of the Jovian planets, the infrared spectrum of 13CH3-12CH3 was measured between 1245 and 1550 cm-1. Using a 99% 13C-enriched ethane sample, spectra were recorded at 0.0022 cm-1 resolution with the 125 HR Bruker FTIR configured to a temperature-controlled absorption cell of 0.204 m path length cooled to 130.3 K. From these, we obtained the first analysis of isotopic ethane for the three fundamentals (v4, v9 and v10) and one combination band (v6+v11). The spectrum itself is very complex; while torsional splitting produces two components (as in normal ethane), there are additional small splittings in both v9 and v10 wherever the normally infrared inactive v10 levels are perturbed by interaction with nearby states of v9. The spectrum was assigned and analyzed by adopting an appropriate Hamiltonian model; vibration-rotation-torsion parameters of these four bands were determined by the least squares process to model 1348 observed line positions with an RMS deviation of 3.24×10-3 cm-1. The values of rotational and torsional parameters of the vibrational ground state were also improved or determined using the new cold spectrum. The parallel band v4 has very perturbed intensity patterns (e. g. with the R-transitions markedly stronger than the P-transitions) due to its Coriolis coupling with v9, and future analysis of the intensities is needed to obtain reliable predictions of this spectrum. For the interim, an empirical linelist is being formed by combining measured positions and intensities at 130 K with lower state energies from known quantum assignments so that lines of this molecule can be identified in planetary spectra. Part of the research described in this paper was performed at the Jet Propulsion Laboratory, California Institute of Technology, Connecticut College, and NASA Langley under contract with the National Aeronautics and Space Administration.

  16. 12 CFR 3.12-3.19 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false 3.12-3.19 Section 3.12-3.19 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY CAPITAL ADEQUACY STANDARDS Capital Ratio Requirements and Buffers §§ 3.12-3.19...

  17. 12 CFR 337.6 - Brokered deposits.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... part, the capital measure terms are defined in the following regulations: FDIC—12 CFR part 325, subpart B; Board of Governors of the Federal Reserve System—12 CFR part 208; Office of the Comptroller of the Currency—12 CFR part 6; Office of Thrift Supervision—12 CFR part 565. (ii) If the...

  18. 12 CFR 337.6 - Brokered deposits.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... part, the capital measure terms are defined in the following regulations: FDIC—12 CFR part 325, subpart B; Board of Governors of the Federal Reserve System—12 CFR part 208; Office of the Comptroller of the Currency—12 CFR part 6; Office of Thrift Supervision—12 CFR part 565. (ii) If the...

  19. 12 CFR 337.6 - Brokered deposits.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... part, the capital measure terms are defined in the following regulations: FDIC—12 CFR part 325, subpart B; Board of Governors of the Federal Reserve System—12 CFR part 208; Office of the Comptroller of the Currency—12 CFR part 6; Office of Thrift Supervision—12 CFR part 565. (ii) If the...

  20. 12 CFR 337.6 - Brokered deposits.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... part, the capital measure terms are defined in the following regulations: FDIC—12 CFR part 325, subpart B; Board of Governors of the Federal Reserve System—12 CFR part 208; Office of the Comptroller of the Currency—12 CFR part 6; Office of Thrift Supervision—12 CFR part 565. (ii) If the...

  1. 12 CFR 26.6 - General exemption.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...; or (4) Is deemed to be in “troubled condition” as defined in 12 CFR 5.51(c)(6). (c) Duration. Unless... 12 Banks and Banking 1 2011-01-01 2011-01-01 false General exemption. 26.6 Section 26.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS §...

  2. Rabbit Achilles tendon full transection model - wound healing, adhesion formation and biomechanics at 3, 6 and 12 weeks post-surgery.

    PubMed

    Meier Bürgisser, Gabriella; Calcagni, Maurizio; Bachmann, Elias; Fessel, Gion; Snedeker, Jess G; Giovanoli, Pietro; Buschmann, Johanna

    2016-01-01

    After tendon rupture repair, two main problems may occur: re-rupture and adhesion formation. Suitable non-murine animal models are needed to study the healing tendon in terms of biomechanical properties and extent of adhesion formation. In this study 24 New Zealand White rabbits received a full transection of the Achilles tendon 2 cm above the calcaneus, sutured with a 4-strand Becker suture. Post-surgical analysis was performed at 3, 6 and 12 weeks. In the 6-week group, animals received a cast either in a 180 deg stretched position during 6 weeks (adhesion provoking immobilization), or were re-casted with a 150 deg position after 3 weeks (adhesion inhibiting immobilization), while in the other groups (3 and 12 weeks) a 180 deg position cast was applied for 3 weeks. Adhesion extent was analyzed by histology and ultrasound. Histopathological scoring was performed according to a method by Stoll et al. (2011), and the main biomechanical properties were assessed. Histopathological scores increased as a function of time, but did not reach values of healthy tendons after 12 weeks (only around 15 out of 20 points). Adhesion provoking immobilization led to an adhesion extent of 82.7±9.7%, while adhesion inhibiting immobilization led to 31.9±9.8% after 6 weeks. Biomechanical properties increased over time, however, they did not reach full strength nor elastic modulus at 12 weeks post-operation. Furthermore, the rabbit Achilles tendon model can be modulated in terms of adhesion formation to the surrounding tissue. It clearly shows the different healing stages in terms of histopathology and offers a suitable model regarding biomechanics because it exhibits similar biomechanics as the human flexor tendons of the hand. PMID:27635037

  3. Rabbit Achilles tendon full transection model – wound healing, adhesion formation and biomechanics at 3, 6 and 12 weeks post-surgery

    PubMed Central

    Meier Bürgisser, Gabriella; Calcagni, Maurizio; Bachmann, Elias; Fessel, Gion; Snedeker, Jess G.; Giovanoli, Pietro

    2016-01-01

    ABSTRACT After tendon rupture repair, two main problems may occur: re-rupture and adhesion formation. Suitable non-murine animal models are needed to study the healing tendon in terms of biomechanical properties and extent of adhesion formation. In this study 24 New Zealand White rabbits received a full transection of the Achilles tendon 2 cm above the calcaneus, sutured with a 4-strand Becker suture. Post-surgical analysis was performed at 3, 6 and 12 weeks. In the 6-week group, animals received a cast either in a 180 deg stretched position during 6 weeks (adhesion provoking immobilization), or were re-casted with a 150 deg position after 3 weeks (adhesion inhibiting immobilization), while in the other groups (3 and 12 weeks) a 180 deg position cast was applied for 3 weeks. Adhesion extent was analyzed by histology and ultrasound. Histopathological scoring was performed according to a method by Stoll et al. (2011), and the main biomechanical properties were assessed. Histopathological scores increased as a function of time, but did not reach values of healthy tendons after 12 weeks (only around 15 out of 20 points). Adhesion provoking immobilization led to an adhesion extent of 82.7±9.7%, while adhesion inhibiting immobilization led to 31.9±9.8% after 6 weeks. Biomechanical properties increased over time, however, they did not reach full strength nor elastic modulus at 12 weeks post-operation. Furthermore, the rabbit Achilles tendon model can be modulated in terms of adhesion formation to the surrounding tissue. It clearly shows the different healing stages in terms of histopathology and offers a suitable model regarding biomechanics because it exhibits similar biomechanics as the human flexor tendons of the hand. PMID:27635037

  4. A Historical Evaluation of the U12t Tunnel, Nevada Test Site, Nye County, Nevada, Volume 3 of 6

    SciTech Connect

    Harold Drollinger; Robert C. Jones; and Thomas F. Bullard; Desert Research Institute, Laurence J. Ashbaugh, Southern Nevada Courier Service and Wayne R. Griffin, Stoller-Navarro Joint Venture

    2009-02-01

    This report presents a historical evaluation of the U12t Tunnel on the Nevada Test Site in southern Nevada. The work was conducted by the Desert Research Institute at the request of the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office and the U.S. Department of Defense, Defense Threat Reduction Agency (DTRA). The U12t Tunnel is one of a series of tunnels used for underground nuclear weapons effects tests on the east side of Rainier and Aqueduct Mesas. Six nuclear weapons effects tests, Mint Leaf, Diamond Sculls, Husky Pup, Midas Myth/Milagro, Mighty Oak, and Mission Ghost, and one high explosive test, SPLAT, were conducted within the U12t Tunnel from 1970 to 1987. All six of the nuclear weapons effects tests and the high explosive test were sponsored by DTRA. Two conventional weapons experiments, Dipole Knight and Divine Eagle, were conducted in the tunnel portal area in 1997 and 1998. These experiments were sponsored by the Defense Special Weapons Agency. The U12t Tunnel complex is composed of the Portal and Mesa Areas and includes an underground tunnel with a main access drift and nine primary drifts, a substantial tailings pile fronting the tunnel portal, a series of discharge ponds downslope of the tailings pile, and two instrumentation trailer parks and 16 drill holes on top of Aqueduct Mesa. A total of 89 cultural features were recorded: 54 at the portal and 35 on the mesa. In the Portal Area, cultural features are mostly concrete pads and building foundations; other features include the portal, rail lines, the camel back, ventilation and cooling system components, communication equipment, and electrical equipment. On the mesa are drill holes, a few concrete pads, a loading ramp, and electrical equipment.

  5. 12 CFR 703.6 - Credit analysis.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Credit analysis. 703.6 Section 703.6 Banks and... ACTIVITIES § 703.6 Credit analysis. A Federal credit union must conduct and document a credit analysis on an... Federal Deposit Insurance Corporation. A Federal credit union must update this analysis at least...

  6. 12 CFR 703.6 - Credit analysis.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Credit analysis. 703.6 Section 703.6 Banks and... ACTIVITIES § 703.6 Credit analysis. A Federal credit union must conduct and document a credit analysis on an... Federal Deposit Insurance Corporation. A Federal credit union must update this analysis at least...

  7. Polarization degrees of 3p 2P3/2-3s 2S1/2 transition in O5+(1s 23p) produced in collisions of O6+ with He and H2

    NASA Astrophysics Data System (ADS)

    Zhao, Y. Q.; Liu, L.; Xue, P.; Wang, J. G.; Janev, R. K.

    2010-09-01

    Electron capture processes in collisions of O6+ with ground state He and H2 are investigated using the two-centre atomic orbital close-coupling method. Total and state-selective one-electron capture cross sections are obtained for collision energies between 0.5 and 300 keV/u. The comparison with the available experimental state-selective capture data in the overlapping energy range (0.5-100 keV/u for O6++He and 0.5-8 keV/u for O6++H2) shows a good overall agreement. The polarization degrees of 3p 2P3/2-3s 2S1/2 radiation from O5+(3p 2P3/2) produced in O6++He and O6++H2 collisions are calculated from the magnetic substate-selective cross sections with inclusion of cascade contributions from higher n = 4 and n = 5 states. Good agreement is obtained with the experimental data available in the energy range 3-8 keV/u. Below ~10 keV/u, the polarization degrees of O5+(3p 2P3/2) in both collision systems exhibit an oscillatory structure and above this energy they steadily increase with the increase of collision energy, reaching the values of about 0.37 at 300 keV/u. The energy behaviour of the polarization degree of O5+(3p 2P3/2) in the O6++He collision system is determined almost exclusively by the direct electron capture to 3p0 and 3p1 states of O5+, while in the case of the O6++H2 collision system in the energy region below ~40 keV/u it is strongly affected by the cascade contributions from the 4l states, which are the dominant capture states in this system.

  8. 12 CFR 212.6 - General exemption.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... to be in “troubled condition” as defined in 12 CFR 225.71. (c) Duration. Unless a shorter expiration... 12 Banks and Banking 2 2010-01-01 2010-01-01 false General exemption. 212.6 Section 212.6 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM...

  9. 12 CFR 348.6 - General exemption.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... section are set forth in 12 CFR 303.249. ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false General exemption. 348.6 Section 348.6 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL...

  10. 12 CFR 212.6 - General exemption.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... to be in “troubled condition” as defined in 12 CFR 225.71. (c) Duration. Unless a shorter expiration... 12 Banks and Banking 2 2011-01-01 2011-01-01 false General exemption. 212.6 Section 212.6 Banks and Banking FEDERAL RESERVE SYSTEM BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM...

  11. Cs7Sm11[TeO3]12Cl16 and Rb7Nd11[TeO3]12Br16, the new tellurite halides of the tetragonal Rb6LiNd11[SeO3]12Cl16 structure type

    NASA Astrophysics Data System (ADS)

    Charkin, Dmitri O.; Black, Cameron; Downie, Lewis J.; Sklovsky, Dmitry E.; Berdonosov, Peter S.; Olenev, Andrei V.; Zhou, Wuzong; Lightfoot, Philip; Dolgikh, Valery A.

    2015-12-01

    Two new rare-earth - alkali - tellurium oxide halides were synthesized by a salt flux technique and characterized by single-crystal X-ray diffraction. The structures of the new compounds Cs7Sm11[TeO3]12Cl16 (I) and Rb7Nd11[TeO3]12Br16 (II) (both tetragonal, space group I4/mcm) correspond to the sequence of [MLn11(TeO3)12] and [M6X16] layers and bear very strong similarities to those of known selenite analogs. We discuss the trends in similarities and differences in compositions and structural details between the Se and Te compounds; more members of the family are predicted.

  12. Superfund record of decision (EPA Region 6): Longhorn Army Ammunition Plant, Burning Ground Number 3, Karnack, TX, May 12, 1995

    SciTech Connect

    1996-03-01

    This decision document presents the selected Early Interim Remedial Action for the Burning Ground No. 3 site (the site), Longhorn Army Ammunition Plant, in Karnack, Texas. The major components of the selected remedy include: extraction and Treatment of contaminated shallow groundwater using Organic Air Stripping and Off-gas Treatment and Metals precipitation, and Excavation and Treatment of Source Material using Low Temperature Thermal Desorption and Catalytic Oxidation for off-gas.

  13. Aktashite Cu6Hg3As4S12 from the Aktash deposit, Altai, Russia: Refinement and crystal chemical analysis of the structure

    NASA Astrophysics Data System (ADS)

    Vasil'Ev, V. I.; Pervukhina, N. V.; Borisov, S. V.; Magarill, S. A.; Naumov, D. Yu.; Kurat'eva, N. V.

    2010-12-01

    The composition and structure of aktashite from the Aktash deposit, Gorny Altai, Russia, have been studied by electron microprobe and X-ray structural analysis. On the basis of close compositions and crystal structures, the identity of aktashite from the Gal-Khaya and Aktash deposits has been demonstrated. Crystals of aktashite are of trigonal symmetry; the unit-cell dimensions are: a = 13.7500(4), c = 9.3600(3) Å, V = 532.54(8) Å3, space group R3, Z = 3 for the composition of Cu6Hg3As4S12, R = 0.043. The structure of aktashite as a framework of vertex-shared HgS4- and CuS4- tetrahedrons of the same orientation is intimately related to the sphalerite-type structure. The earlier identified uncommon cluster group [As4] has been verified and its parameters have been refined. It is shown that the structure may be represented as construction blocks (As4S12)12- packed according to the law of the distorted cubic I-cell.

  14. Low-level laser (light) therapy increases mitochondrial membrane potential and ATP synthesis in C2C12 myotubes with a peak response at 3-6 h.

    PubMed

    Ferraresi, Cleber; Kaippert, Beatriz; Avci, Pinar; Huang, Ying-Ying; de Sousa, Marcelo V P; Bagnato, Vanderlei S; Parizotto, Nivaldo A; Hamblin, Michael R

    2015-01-01

    Low-level laser (light) therapy has been used before exercise to increase muscle performance in both experimental animals and in humans. However, uncertainty exists concerning the optimum time to apply the light before exercise. The mechanism of action is thought to be stimulation of mitochondrial respiration in muscles, and to increase adenosine triphosphate (ATP) needed to perform exercise. The goal of this study was to investigate the time course of the increases in mitochondrial membrane potential (MMP) and ATP in myotubes formed from C2C12 mouse muscle cells and exposed to light-emitting diode therapy (LEDT). LEDT employed a cluster of LEDs with 20 red (630 ± 10 nm, 25 mW) and 20 near-infrared (850 ± 10 nm, 50 mW) delivering 28 mW cm(2) for 90 s (2.5 J cm(2)) with analysis at 5 min, 3 h, 6 h and 24 h post-LEDT. LEDT-6 h had the highest MMP, followed by LEDT-3 h, LEDT-24 h, LEDT-5 min and Control with significant differences. The same order (6 h > 3 h > 24 h > 5 min > Control) was found for ATP with significant differences. A good correlation was found (r = 0.89) between MMP and ATP. These data suggest an optimum time window of 3-6 h for LEDT stimulate muscle cells.

  15. High level accumulation of gamma linolenic acid (C18:3Δ6.9,12 cis) in transgenic safflower (Carthamus tinctorius) seeds.

    PubMed

    Nykiforuk, Cory L; Shewmaker, Christine; Harry, Indra; Yurchenko, Olga P; Zhang, Mei; Reed, Catherine; Oinam, Gunamani S; Zaplachinski, Steve; Fidantsef, Ana; Boothe, Joseph G; Moloney, Maurice M

    2012-04-01

    Gamma linolenic acid (GLA; C18:3Δ6,9,12 cis), also known as γ-Linolenic acid, is an important essential fatty acid precursor for the synthesis of very long chain polyunsaturated fatty acids and important pathways involved in human health. GLA is synthesized from linoleic acid (LA; C18:2Δ9,12 cis) by endoplasmic reticulum associated Δ6-desaturase activity. Currently sources of GLA are limited to a small number of plant species with poor agronomic properties, and therefore an economical and abundant commercial source of GLA in an existing crop is highly desirable. To this end, the seed oil of a high LA cultivated species of safflower (Carthamus tinctorius) was modified by transformation with Δ6-desaturase from Saprolegnia diclina resulting in levels exceeding 70% (v/v) of GLA. Levels around 50% (v/v) of GLA in seed oil was achieved when Δ12-/Δ6-desaturases from Mortierella alpina was over-expressed in safflower cultivars with either a high LA or high oleic (OA; C18:1Δ9 cis) background. The differences in the overall levels of GLA suggest the accumulation of the novel fatty acid was not limited by a lack of incorporation into the triacylgylcerol backbone (>66% GLA achieved), or correlated with gene dosage (GLA levels independent of gene copy number), but rather reflected the differences in Δ6-desaturase activity from the two sources. To date, these represent the highest accumulation levels of a newly introduced fatty acid in a transgenic crop. Events from these studies have been propagated and recently received FDA approval for commercialization as Sonova™400.

  16. 40 CFR 721.9790 - Benzenesulfonic acid, 2,2′-(1,2-ethenediyl)bis[5-[[4-[bis(2-hydroxypropyl) amino]- 6-[(3...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6-......

  17. 40 CFR 721.9790 - Benzenesulfonic acid, 2,2′-(1,2-ethenediyl)bis[5-[[4-[bis(2-hydroxypropyl) amino]- 6-[(3...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6-......

  18. 40 CFR 721.9790 - Benzenesulfonic acid, 2,2′-(1,2-ethenediyl)bis[5-[[4-[bis(2-hydroxypropyl) amino]- 6-[(3...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6-......

  19. 40 CFR 721.9790 - Benzenesulfonic acid, 2,2′-(1,2-ethenediyl)bis[5-[[4-[bis(2-hydroxypropyl) amino]- 6-[(3...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6-......

  20. 40 CFR 721.9790 - Benzenesulfonic acid, 2,2′-(1,2-ethenediyl)bis[5-[[4-[bis(2-hydroxypropyl) amino]- 6-[(3...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6- -1,3,5-triazin-2-yl]amino]-2-sulfophenyl]ethenyl...); Benzenesulfonic acid, 5- -6- -1,3,5-triazin-2-yl]amino]-2- -6-......

  1. 12 CFR 703.6 - Credit analysis.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Credit analysis. 703.6 Section 703.6 Banks and... ACTIVITIES § 703.6 Credit analysis. A Federal credit union must conduct and document a credit analysis on an... Federal Deposit Insurance Corporation. A Federal credit union must update this analysis at least...

  2. 12 CFR 703.6 - Credit analysis.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Credit analysis. 703.6 Section 703.6 Banks and... ACTIVITIES § 703.6 Credit analysis. A Federal credit union must conduct and document a credit analysis on an... Federal Deposit Insurance Corporation. A Federal credit union must update this analysis at least...

  3. 12 CFR 703.6 - Credit analysis.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Credit analysis. 703.6 Section 703.6 Banks and... ACTIVITIES § 703.6 Credit analysis. A Federal credit union must conduct and document a credit analysis on an... Federal Deposit Insurance Corporation. A Federal credit union must update this analysis at least...

  4. 12 CFR 1264.6 - Appeals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Appeals. 1264.6 Section 1264.6 Banks and... § 1264.6 Appeals. (a) General. Within 90 calendar days of the date of a Bank's decision to deny an application for certification as a housing associate, the applicant may submit a written appeal to FHFA...

  5. 12 CFR 1264.6 - Appeals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Appeals. 1264.6 Section 1264.6 Banks and... § 1264.6 Appeals. (a) General. Within 90 calendar days of the date of a Bank's decision to deny an application for certification as a housing associate, the applicant may submit a written appeal to FHFA...

  6. 12 CFR 1272.6 - FHFA consent.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false FHFA consent. 1272.6 Section 1272.6 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS NEW BUSINESS ACTIVITIES § 1272.6 FHFA consent. The FHFA may at any time provide consent for a Bank to undertake a particular new...

  7. 12 CFR 918.6 - Disclosure.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Disclosure. 918.6 Section 918.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD GOVERNANCE AND MANAGEMENT OF THE FEDERAL HOME LOAN BANKS BANK DIRECTOR COMPENSATION AND EXPENSES § 918.6 Disclosure. Each Bank shall, in its annual report: (a) State...

  8. 12 CFR 348.6 - General exemption.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false General exemption. 348.6 Section 348.6 Banks... MANAGEMENT OFFICIAL INTERLOCKS § 348.6 General exemption. (a) Exemption. The FDIC may by agency order exempt... of competition if the depository organization seeking to add a management official: (1)...

  9. 12 CFR 711.6 - General exemption.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false General exemption. 711.6 Section 711.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS MANAGEMENT... or substantial lessening of competition if the depository organization seeking to add a...

  10. 12 CFR 26.6 - General exemption.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false General exemption. 26.6 Section 26.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS § 26.6... of competition if the depository organization seeking to add a management official: (1)...

  11. 12 CFR 352.6 - Employment.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CFR parts 1614 and 1630, shall apply to employment in the FDIC. ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Employment. 352.6 Section 352.6 Banks and... NONDISCRIMINATION ON THE BASIS OF DISABILITY § 352.6 Employment. No qualified individual with a disability shall,...

  12. 12 CFR 952.6 - Reporting.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Reporting. 952.6 Section 952.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS COMMUNITY INVESTMENT CASH ADVANCE PROGRAMS § 952.6 Reporting. (a) By July 1, 1999, each Bank shall provide to...

  13. 12 CFR 926.6 - Appeals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Appeals. 926.6 Section 926.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK MEMBERS AND HOUSING ASSOCIATES FEDERAL HOME LOAN BANK HOUSING ASSOCIATES § 926.6 Appeals. (a) General. Within 90 calendar days of the date of a Bank's...

  14. 12 CFR 583.6 - Company.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Company. 583.6 Section 583.6 Banks and Banking... AND LOAN HOLDING COMPANIES § 583.6 Company. The term company means any corporation, partnership, trust, joint-stock company, or similar organization, but does not include: (a) The Federal Deposit...

  15. 12 CFR 711.6 - General exemption.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false General exemption. 711.6 Section 711.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS MANAGEMENT... interlock would not result in a monopoly or substantial lessening of competition, and would not...

  16. 12 CFR 1.6 - Convertible securities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Convertible securities. 1.6 Section 1.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY INVESTMENT SECURITIES § 1.6 Convertible securities. A national bank may not purchase securities convertible into stock at the option...

  17. 12 CFR 32.6 - Nonconforming loans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Nonconforming loans. 32.6 Section 32.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY LENDING LIMITS § 32.6... inconsistent with safe and sound banking practices. (c) A bank must bring a loan that is nonconforming as...

  18. 12 CFR 1.6 - Convertible securities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Convertible securities. 1.6 Section 1.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY INVESTMENT SECURITIES § 1.6 Convertible securities. A national bank may not purchase securities convertible into stock at the option...

  19. 12 CFR 1102.6 - Waiver extension.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Waiver extension. 1102.6 Section 1102.6 Banks and Banking FEDERAL FINANCIAL INSTITUTIONS EXAMINATION COUNCIL APPRAISER REGULATION Temporary Waiver Requests § 1102.6 Waiver extension. The ASC may initiate an extension of temporary waiver relief and...

  20. 12 CFR 552.6 - Shareholders.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations under the Securities and Exchange Act of 1934 (17 CFR 240.14a-7) as may be duly requested in... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Shareholders. 552.6 Section 552.6 Banks and..., ORGANIZATION, AND CONVERSION § 552.6 Shareholders. (a) Shareholder meetings. An annual meeting of...

  1. 12 CFR 1.6 - Convertible securities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Convertible securities. 1.6 Section 1.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY INVESTMENT SECURITIES § 1.6 Convertible securities. A national bank may not purchase securities convertible into stock at the option...

  2. Genetic structures of the genes encoding 2,3-dihydroxybiphenyl 1,2-dioxygenase and 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid hydrolase from biphenyl- and 4-chlorobiphenyl-degrading Psudomonas sp. strain DJ-12

    SciTech Connect

    Kim, Eunheui; Kim, Chi-Kyung; Kim, Youngsoo

    1996-01-01

    Polychlorinated biphenyls (PCBs) are recognized as a groups of the most persistent pollutants. Many bacterial strains are recognized as PCB and biphenyl degraders, and after further degradation their catabolites are ultimate utilized as carbon and energy sources. Pseudomonas sp. is a natural isolate which can grow in biphenyl or 4-chlorobiphenyl as the sole carbon and energy source. In this study, nucleotide sequences of the pcbC and pcbD genes of Pseudomonas sp. strain D-J-12 were analyzed. 29 refs., 3 figs., 1 tab.

  3. Crystal structure of 2-aza­niumyl-3-bromo-6-oxo-5,6-di­hydro­pyrido[1,2-a]quinoxalin-11-ium dibromide

    PubMed Central

    Faizi, Md. Serajul Haque; Sharkina, Natalia O.; Iskenderov, Turganbay S.

    2015-01-01

    The title salt, C12H10BrN3O2+·2Br−, was synthesized from the reaction of N 1,N 4-bis­(pyridin-2-yl­methyl­idene)benzene-1,4-di­amine and bromine in a methanol solution. All non-H atoms of the 2-aza­niumyl-3-bromo-6-oxo-5,6-di­hydro­pyrido[1,2-a]quinoxalin-11-ium cation are nearly coplanar, the maximum deviation being 0.114 (4) Å. In the crystal, the cations and anions are linked through N—H⋯Br hydrogen bonds and weak C—H⋯Br inter­actions, forming a three-dimensional supra­molecular architecture. A short Br⋯Br contact [3.3088 (9) Å] is observed in the crystal. PMID:25705482

  4. 12 CFR 5.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... OCC's risk-based capital standards set forth in appendix A to 12 CFR part 3 as reported in the bank's...: (1) Is well capitalized as defined in 12 CFR 6.4(b)(1); (2) Has a composite rating of 1 or 2 under... 12 CFR part 6, subpart B) or, if subject to any such order, agreement, or directive, is informed...

  5. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1111, LB4822_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1111, LB4822_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  6. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1212, LB4827_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1212, LB4827_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  7. Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1511, LB4832_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume A 'Binary Liquid Systems of Nonelectrolytes I' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture Cyclohexanone C6H10O + C9H12 1,3,5-Trimethylbenzene (VMSD1511, LB4832_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  8. Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1511, LB5121_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1511, LB5121_V)' providing data from direct measurement of low-pressure thermodynamic speed of sound at variable mole fraction and constant temperature, in the single-phase region(s).

  9. Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1111, LB5124_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1111, LB5124_V)' providing data from direct low-pressure measurement of mass density at variable mole fraction and constant temperature, in the single-phase region(s).

  10. Heat of Mixing and Solution of 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (HMSD1111, LB4308_H)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Heat of Mixing and Solution of 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (HMSD1111, LB4308_H)' providing data from direct low-pressure calorimetric measurement of molar excess enthalpy at variable mole fraction and constant temperature.

  11. Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1212, LB5126_V)

    NASA Astrophysics Data System (ADS)

    Cibulka, I.; Fontaine, J.-C.; Sosnkowska-Kehiaian, K.; Kehiaian, H. V.

    This document is part of Subvolume B 'Binary Liquid Systems of Nonelectrolytes II' of Volume 26 'Heats of Mixing, Vapor-Liquid Equilibrium, and Volumetric Properties of Mixtures and Solutions' of Landolt-Börnstein Group IV 'Physical Chemistry'. It contains the Chapter 'Volumetric Properties of the Mixture 1,3-Dioxane C4H8O2 + C6H12 Cyclohexane (VMSD1212, LB5126_V)' providing data by calculation of molar excess volume from low-pressure density measurements at variable mole fraction and constant temperature.

  12. Crystal structure of 2-(4-meth-oxy-phen-yl)-6-nitro-imidazo[1,2-a]pyridine-3-carbaldehyde.

    PubMed

    Koudad, Mohamed; Elaatiaoui, Abdelmalik; Benchat, Noureddine; Saadi, Mohamed; El Ammari, Lahcen

    2015-12-01

    In the title compound, C15H11N3O4, the imidazo[1,2-a] pyridine ring system is almost planar [r.m.s. deviation = 0.028 (2) Å]. Its mean plane makes dihedral angles of 33.92 (7) and 34.56 (6)° with the meth-oxy-phenyl ring and the nitro group, respectively. The cohesion of the crystal structure is ensured by C-H⋯N and C-H⋯O hydrogen bonds, forming layers almost parallel to the ac plane. PMID:26870561

  13. Unexpected ring-closure products derived from 3-(2-allylanilino)-3-phenylacrylate esters: crystal and molecular structures of 3-acetyl-8-allyl-6-methyl-2-phenylquinolin-4-yl acetate and (2RS)-2,8-dimethyl-4-phenyl-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinolin-6-one.

    PubMed

    Luque, Adriana L; Sanabria, Carlos M; Palma, Alirio; Cobo, Justo; Glidewell, Christopher

    2016-08-01

    The reactions of two 3-(2-allylanilino)-3-phenylacrylate esters with acetic anhydride and with strong acids has revealed a richly diverse reactivity providing a number of unexpected products. Thus, acetylation of ethyl 3-(2-allylanilino)-3-phenylacrylate, (Ia), or ethyl 3-(2-allyl-4-methylanilino)-3-phenylacrylate, (Ib), with acetic anhydride yields not only the expected acetylated esters, (II), as the major products but also the unexpected polysubstituted quinolines 3-acetyl-8-allyl-2-phenylquinolin-4-yl acetate, (IIIa), and 3-acetyl-8-allyl-6-methyl-2-phenylquinolin-4-yl acetate, (IIIb), as minor products. Subsequent reaction of the major product ethyl 2-[(2-allyl-4-methylanilino)(phenyl)methylidene]-3-oxobutanoate, (IIb), with concentrated sulfuric acid did not provide the expected 3-acetylquinoline derivative, but instead two unexpected products, namely ethyl 4-ethyl-2-phenyl-1,4-dihydroquinoline-3-carboxylate, (IV), and ethyl 3-acetyl-4-ethyl-2-phenyl-3,4-dihydroquinoline-3-carboxylate, (V), in yields of 39 and 22%, respectively. The reaction of (Ib) with Eaton's reagent gave both the quinoline (Z)-6-methyl-2-phenyl-8-(prop-1-en-1-yl)quinolin-4(1H)-one, (VI), and the unexpected tricyclic product (2RS)-2,8-dimethyl-4-phenyl-1,2-dihydro-6H-pyrrolo[3,2,1-ij]quinolin-6-one, (VII), in yields of 71 and 12%, respectively. The products (II)-(VII) have all been fully characterized spectroscopically and the crystal structures of two of the unexpected products, i.e. (IIIb) (C23H21NO3) and (VII) (C19H17NO), are reported here. The formation of compounds (IV), (V) and (VII) all require an isomerization of the initial allyl substituent, with migration of the C=C double bond from the terminal site to the internal site. In (IIIb), the two acetyl substituents are oriented such that the intramolecular distance between the two carbonyl O atoms is only 3.243 (2) Å, and in (VII), the five-membered ring adopts a twisted half-chair conformation. The molecules of compound (IIIb

  14. Crystal growth and characterization of a novel inorganic-organic hybrid NLO crystal: (NH4)[Cd(NCS)3]·C12H24O6

    NASA Astrophysics Data System (ADS)

    Ramesh, V.; Rajarajan, K.

    2013-10-01

    It is reported here, for the first time, that high-quality bulk size (18 × 5 × 4 mm3) single crystals of a new nonlinear optical crystal, [(NH4)[Cd(NCS)3]·C12H24O6] [Ammonium (18-crown-6-ether) Cadmium(II) tri-thiocyanate; ACCTC], have been grown from aqueous solution via slow evaporation technique. Solubility of ACCTC has been determined for various temperatures. The grown crystals were characterized by single crystal X-ray diffraction, FT-IR, FT-Raman, and UV-Vis-NIR studies. ACCTC crystallizes in orthorhombic system with cell parameters a = 14.7568 Ǻ, b = 15.4378 Ǻ, and c = 10.6383 Ǻ with space group Cmc21. The optical second-harmonic generation effect has been measured by using the Kurtz powder technique and is found to be 2 times higher than that of KDP (KH2PO4). The sample possesses wide optical transparency range from 200 to 2,500 nm. The TG-DSC thermal analysis revealed that the sample is thermally stable up to 237.92 °C, which is comparatively far better than the thermal stability of [(18C6)Li][Cd(SCN)3]; CLTC (170 °C).

  15. 12 CFR 952.6 - Reporting.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Reporting. 952.6 Section 952.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS COMMUNITY... reports concerning its CICA programs as the Finance Board may request from time to time....

  16. 12 CFR 952.6 - Reporting.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Reporting. 952.6 Section 952.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS COMMUNITY... reports concerning its CICA programs as the Finance Board may request from time to time....

  17. 12 CFR 952.6 - Reporting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Reporting. 952.6 Section 952.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS COMMUNITY... reports concerning its CICA programs as the Finance Board may request from time to time....

  18. 12 CFR 563f.6 - General exemption.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false General exemption. 563f.6 Section 563f.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS... organization seeking to add a management official: (1) Primarily serves low- and moderate-income areas; (2)...

  19. 45 CFR 12a.6 - Suitability criteria.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... ASSIST THE HOMELESS § 12a.6 Suitability criteria. (a) All properties, buildings and land will be... substances such as radon, periodic flooding, sinkholes or earth slides. (6) Inaccessible. A property that is... (including property on small off-shore islands) or is land locked (e.g., can be reached only by...

  20. 45 CFR 12a.6 - Suitability criteria.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... ASSIST THE HOMELESS § 12a.6 Suitability criteria. (a) All properties, buildings and land will be... substances such as radon, periodic flooding, sinkholes or earth slides. (6) Inaccessible. A property that is... (including property on small off-shore islands) or is land locked (e.g., can be reached only by...

  1. 12 CFR 563f.6 - General exemption.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false General exemption. 563f.6 Section 563f.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS... lessening of competition and would not present safety and soundness concerns. A depository organization...

  2. 12 CFR 3.12 - Procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... circumstances affecting the bank's capital adequacy or its ability to reach the required minimum capital ratios... COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MINIMUM CAPITAL RATIOS; ISSUANCE OF DIRECTIVES Establishment of Minimum Capital Ratios for an Individual Bank § 3.12 Procedures. (a) Notice. When the...

  3. A magnetization study of RCo 12B 6 intermetallics

    NASA Astrophysics Data System (ADS)

    Mittag, M.; Rosenberg, M.; Buschow, K. H. J.

    1989-11-01

    The magnetic properties of polycrystalline intermetallics RCo 12B 6 with R = Y, La, Ce, Pr, Nd, Sm, Gd, Tb, Dy, Ho, Er and Tm have been studied in the temperature range 3-300 K and in fields up to 2 T. All compounds order magnetically between Tc=134.3 K for CeCo 12B 6 and Tc=162 K for GdCo 12B 6. YCo 12B 6 has an average Co moment of 0.42μ B. Since the Co moment is constant for all samples the R moments can be easily obtained and they are in good agreement with free R 3+ ion values. Ce is quadripositive in CeCo 12B 6 and therefore nonmagnetic. All light rare-earth compounds are ferromagnetic, while all heavy rare-earth compounds are ferrimagnetic with compensation points between Tcomp=11.6 K ( TmCo12B6) and Tcomp=82.8 K ( TbCo12B6). In the paramagnetic state an effective magnetic moment of 1.94μ B per Co atom has been found. The mean-field approximation yields a 3d-3d exchange integral of {J CoCo}/{k B}=110 K . The 3d-4f exchange integral is much smaller and equal to about {J RCo}/{k B}=6 K .

  4. In vitro induction of O6-methylguanine-DNA methyltransferase in C3H/10T1/2 cells by X-rays is inhibited by nitrogen.

    PubMed

    von Hofe, E; Kennedy, A R

    1988-04-01

    Ionizing radiation is one of the most potent inducers of O6-methylguanine-DNA methyltransferase (MT) in rat liver in vivo. In this study we show that MT is readily induced in C3H/10T1/2 cells in culture, which provides a system more amenable to determining the molecular events involved in the induction of this repair enzyme. Maximal induction (2- to 3-fold) was observed in logarithmically growing cells 48 h after a dose of 200 rad, similar to the optimal induction time seen in rat liver in vivo. The absolute level of MT observed in C3H/10T1/2 cells which had been at confluence for 24 h was less than in cells in log growth but was still inducible by X-rays, exhibiting an approximately 2-fold increase over unirradiated cells similar to MT induction in logarithmically growing cells. Irradiating cells under anaerobic conditions (saturated N2) abolished MT induction by 100 rad. Cells irradiated with 200 rad under anaerobic conditions exhibited approximately 70% inhibition of induction compared with aerobically irradiated cells. The possibility that MT may be partially inactivated by interaction with radicals produced by ionizing radiation is discussed.

  5. ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications.

    PubMed

    Chibon, Frédéric; Mariani, Odette; Derré, Josette; Mairal, Aline; Coindre, Jean-Michel; Guillou, Louis; Sastre, Xavier; Pédeutour, Florence; Aurias, Alain

    2004-05-01

    Malignant fibrous histiocytomas (MFHs) are aggressive tumors without any definable line of differentiation. We recently demonstrated that about 20% of them are characterized by high-level amplifications of the 12q14-q15 chromosome region, associated with either 1p32 or 6q23 band amplification. This genetic finding, very similar to that in well-differentiated liposarcomas, strongly suggests that these tumors actually correspond to undifferentiated liposarcomas. It also suggests that the lack of differentiation could be the consequence of amplification of target genes localized in the 1p32 or 6q23 bands. We report here the characterization by array CGH of the 6q23 minimal region of amplification. Our findings demonstrate that amplification and overexpression of ASK1 (MAP3K5), a gene localized in the 6q23 band and encoding a mitogen-activated protein kinase kinase kinase of the JNK-MAPK signaling pathway, could inhibit the adipocytic differentiation process of the tumor cells. Treatment of a cell line with specific inhibitors of ASK1 protein resulted in the bypass of the differentiation block and induction of a strong adipocytic differentiation. These observations indicate that ASK1 is a target for new therapeutic management of these aggressive tumors. PMID:15034865

  6. Growth, spectral, optical, thermal, surface analysis and third order nonlinear optical properties of an organic single crystal: 1-(2-Methyl-6-nitro-4-phenyl-3-quinolyl) ethanone

    NASA Astrophysics Data System (ADS)

    Nirosha, M.; Kalainathan, S.; Sarveswari, S.; Vijayakumar, V.; Srikanth, A.

    2015-02-01

    Single crystal of 1-(2-Methyl-6-nitro-4-phenyl-3-quinolyl) ethanone was grown using slow evaporation solution growth technique. Single crystal X-ray diffraction study reveals the lattice parameters of the grown crystal. The modes of vibration of different molecular groups present in 2M6NQE were identified by FTIR spectral analysis. Its optical behavior was examined through UV-vis-NIR absorption and PL emission spectrum. They signify that the crystal has transparency in the region between 383 and 1100 nm. The PL spectrum of the title compound shows green emission in the crystal. From the thermal analysis, 2M6NQE has found to be thermally stable up to 263 °C, and the melting point of the material is 170 °C. The estimations of third order non-linear optical properties like non-linear absorption coefficient (β), non-linear refractive index (n2) and susceptibility [χ(3)] were calculated using Z-scan technique. It has observed that, crystal exhibits reverse saturation absorption and self-defocusing performance. Etching study was carried out for the grown crystal using different solvents.

  7. 12 CFR 265.6 - Functions delegated to General Counsel.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...) of Regulation K (12 CFR 211.24(a)(6)) shall publish notice of the application or notice in a... business, as provided in § 211.24(b)(2) of Regulation K (12 CFR 211.24(b)(2)). (3) With the concurrence of... Rules of Procedure (12 CFR part 262), in connection with any application or notice filed with the...

  8. 12 CFR 265.6 - Functions delegated to General Counsel.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...) of Regulation K (12 CFR 211.24(a)(6)) shall publish notice of the application or notice in a... business, as provided in § 211.24(b)(2) of Regulation K (12 CFR 211.24(b)(2)). (3) With the concurrence of... Rules of Procedure (12 CFR part 262), in connection with any application or notice filed with the...

  9. 12 CFR 265.6 - Functions delegated to General Counsel.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...) of Regulation K (12 CFR 211.24(a)(6)) shall publish notice of the application or notice in a... business, as provided in § 211.24(b)(2) of Regulation K (12 CFR 211.24(b)(2)). (3) With the concurrence of... Rules of Procedure (12 CFR part 262), in connection with any application or notice filed with the...

  10. 12 CFR 225.6 - Penalties for violations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Hearings (12 CFR part 263, subpart C). For any willful violation of the Bank Control Act or any regulation... 12 Banks and Banking 3 2014-01-01 2014-01-01 false Penalties for violations. 225.6 Section 225.6... (CONTINUED) BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations General...

  11. 12 CFR 225.6 - Penalties for violations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... be made in accordance with subpart C of the Board's Rules of Practice for Hearings (12 CFR part 263... 12 Banks and Banking 3 2012-01-01 2012-01-01 false Penalties for violations. 225.6 Section 225.6... BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations General Provisions §...

  12. 12 CFR 225.6 - Penalties for violations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... be made in accordance with subpart C of the Board's Rules of Practice for Hearings (12 CFR part 263... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Penalties for violations. 225.6 Section 225.6... BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations General Provisions §...

  13. 12 CFR 225.6 - Penalties for violations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Hearings (12 CFR part 263, subpart C). For any willful violation of the Bank Control Act or any regulation... 12 Banks and Banking 3 2013-01-01 2013-01-01 false Penalties for violations. 225.6 Section 225.6... (CONTINUED) BANK HOLDING COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations General...

  14. 12 CFR 46.6 - Stress test methodologies and practices.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... institution under 12 CFR part 3 or part 167, as applicable, and any other capital ratios specified by the OCC... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Stress test methodologies and practices. 46.6 Section 46.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY ANNUAL STRESS...

  15. 12 CFR 46.6 - Stress test methodologies and practices.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... institution under 12 CFR part 3 or part 167, as applicable, and any other capital ratios specified by the OCC... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Stress test methodologies and practices. 46.6 Section 46.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY ANNUAL STRESS...

  16. Theoretical investigations of a high density cage compound 10-(1-nitro-1, 2, 3, 4-tetraazol-5-yl)) methyl-2, 4, 6, 8, 12-hexanitrohexaazaisowurtzitane.

    PubMed

    Zhang, Jian-ying; Du, Hong-chen; Wang, Fang; Gong, Xue-dong; Huang, Yin-sheng

    2012-01-01

    A new polynitro cage compound with the framework of HNIW and a tetrazole unit, i.e., 10-(1-nitro-1, 2, 3, 4-tetraazol-5-yl)) methyl-2, 4, 6, 8, 12-hexanitrohexaazaisowurtzitane (NTz-HNIW) has been proposed and studied by density functional theory (DFT) and molecular mechanics methods. Properties such as IR spectrum, heat of formation, thermodynamic properties, and crystal structure were predicted. The compound belongs to the Pbca space group, with the lattice parameters a = 15.07 Å, b = 12.56 Å, c = 18.34 Å, Z = 8, and ρ = 1.990 g·cm(-3). The stability of the compound was evaluated by the bond dissociation energies and results showed that the first step of pyrolysis is the rupture of the N-NO(2) bond in the side chain. The detonation properties were estimated by the Kamlet-Jacobs equations based on the calculated crystal density and heat of formation, and the results were 9.240 km·s(-1) for detonation velocity and 40.136 GPa for detonation pressure. The designed compound has high thermal stability and good detonation properties and is probably a promising high energy density compound (HEDC).

  17. 7 CFR 12.6 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12... converted wetland by a landlord's tenant or sharecropper is required under the terms and conditions of the... wetland was commenced before December 23, 1985, for the purposes of § 12.5(b)(3); (vii) Whether...

  18. 7 CFR 12.6 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12... converted wetland by a landlord's tenant or sharecropper is required under the terms and conditions of the... wetland was commenced before December 23, 1985, for the purposes of § 12.5(b)(3); (vii) Whether...

  19. 7 CFR 12.6 - Administration.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12... converted wetland by a landlord's tenant or sharecropper is required under the terms and conditions of the... wetland was commenced before December 23, 1985, for the purposes of § 12.5(b)(3); (vii) Whether...

  20. 7 CFR 12.6 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12... converted wetland by a landlord's tenant or sharecropper is required under the terms and conditions of the... wetland was commenced before December 23, 1985, for the purposes of § 12.5(b)(3); (vii) Whether...

  1. 7 CFR 12.6 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12... converted wetland by a landlord's tenant or sharecropper is required under the terms and conditions of the... wetland was commenced before December 23, 1985, for the purposes of § 12.5(b)(3); (vii) Whether...

  2. Davinciite, Na12K3Ca6Fe{3/2+}Zr3(Si26O73OH)Cl2, a New K,Na-Ordered mineral of the eudialyte group from the Khibiny Alkaline Pluton, Kola Peninsula, Russia

    NASA Astrophysics Data System (ADS)

    Khomyakov, A. P.; Nechelyustov, G. N.; Rastsvetaeva, R. K.; Rozenberg, K. A.

    2013-12-01

    This paper presents a description of a new zirconosilicate of the eudialyte group, which was named davinciite in honor of Leonardo da Vinci (1452-1519), a famous Italian scientist, painter, sculptor and architect. The new mineral has been found in hyperagpaitic pegmatite at the Rasvumchorr Mountain, Khibiny Pluton, Kola Peninsula, as relict inclusions, up to 1-2 mm in size in a rastsvetaevite matrix. It is associated with nepheline, sodalite, potassium feldspar, delhayelite, aegirine, shcherbakovite, villiaumite, nitrite, nacaphite, rasvumite, and djerfisherite. Davinciite is dark lavender and transparent, with a vitreous luster and white streak. The new mineral is brittle, with conchoidal fracture; the Mohs' hardness is 5. No indications of cleavage or parting were observed. The measured density is 2.82(2) g/cm3 (volumetric method); the calculated density is 2.848 g/cm3. Davinciite is optically uniaxial, positive; ω = 1.603(2), ɛ = 1.605(2). It is nonpleochroic and nonfluorescent in UV light. The new mineral slowly breaks down and gelates in 50% HCl and HNO3. It is trigonal, space group R3m. The unit-cell dimensions are a = 14.2956(2), c = 30.0228(5) Å, V=5313.6(2) Å3. The strongest reflections in the X-ray powder diffraction pattern [ d, Å ( I, %) ( hkl)] are as follows: 2.981(100)(315), 2.860(96)(404), 4.309(66)(205), 3.207(63)(208), 6.415(54)(104), 3.162(43)(217). The chemical composition (electron microprobe, H2O calculated from X-ray diffraction data) is as follows, wt %: 12.69 Na2O, 3.53 K2O, 11.02 CaO, 0.98 SrO, 0.15 BaO, 5.33 FeO, 0.37 MnO, 0.07 Al2O3, 51.20 SiO2, 0.39 TiO2, 11.33 ZrO2, 0.21HfO2, 0.09 Nb2O5, 1.89 Cl, 0.93H2O, -O = Cl2 0.43; total is 99.75. The empirical formula calculated on the basis of Si + Al + Zr + Hf + Ti + Nb = 29 ( Z = 3) is (Na1l.75Sr0.29Ba0.03)Σ12.07(K2.28Na0.72)Σ3Ca5.99(Fe2.26Mn0.16)Σ2.42(Zr2.80Ti0.15Hf0.03Nb0.02) Σ3(Si1.96Al0.04)Σ2[Si3O9]2 [Si9O27]2[(OH)1.42O0.58]Σ2[Cl1.62(H2O)0.38]Σ2 · 0.48H2O. The simplified

  3. Overview of 12-cm-Diameter, Argon Gas-Puff Experiments and Analyses with >200-ns Implosion Times at 3- to 6-MA Peak Currents

    SciTech Connect

    Commisso, R. J.; Apruzese, J. P.; Davis, J.; Murphy, D. P.; Thornhill, J. W.; Velikovich, A. L.; Weber, B. V.; Jackson, S. L.; Mosher, D.; Young, F. C.; Coverdale, C. A.; Jones, B.

    2009-01-21

    This paper reviews the motivation for, results from, and analyses of 12-cm-diameter argon gas-puff experiments carried out over the last four years on three generators at 3.2- to 6.5-MA peak currents, all with implosion times {>=}200 ns. Using the argon K-shell yield as a metric of implosion quality, high-quality implosions are obtained for an appropriate initial radial mass distribution, i.e., a distribution that is peaked on axis. Higher compressed densities and smaller final radii are observed compared to shell-like initial mass distributions. Theory and data suggest that these distributions mitigate the magnetic Rayleigh-Taylor instability. An energy analysis shows that (1) significant electrical energy is directly coupled to the pinch during the K-shell radiation pulse and (2) conversion of radially-directed kinetic energy into thermal energy is not the dominant mechanism responsible for the pinch K-shell radiation.

  4. A child with mild X-linked intellectual disability and a microduplication at Xp22.12 including RPS6KA3.

    PubMed

    Tejada, María-Isabel; Martínez-Bouzas, Cristina; García-Ribes, Ainhoa; Larrucea, Susana; Acquadro, Francesco; Cigudosa, Juan-C; Belet, Stefanie; Froyen, Guy; López-Aríztegui, Maria-Asun

    2011-10-01

    Multiplex ligation-dependent probe amplification (MLPA) and array- comparative genomic hybridization analysis have been proven to be useful in the identification of submicroscopic copy-number imbalances in families with nonsyndromic X-linked intellectual disability (NS-XLID). Here we report the first description of a child with mild intellectual disability and a submicroscopic duplication at Xp22.12 identified by MLPA with a P106 MRX kit (MRC-Holland, Amsterdam, Netherlands) and further confirmed and characterized with a custom 244-k oligo-array, fluorescence in situ hybridization, quantitative polymerase chain reaction (qPCR), and immunoblotting. This 1.05-megabase duplication encompasses 7 genes, RPS6KA3 being the only of these genes known to be related to ID. The proband was an 8-year-old boy referred to the genetics unit for psychomotor retardation and learning disabilities. Both maternal brothers also showed learning difficulties and delayed language during childhood in a similar way to the proband. These boys also carried the duplication, as did the healthy mother and grandmother of the proband. The same duplication was also observed in the 5-year-old younger brother who presented with features of developmental delay and learning disabilities during the previous year. Increased RPS6KA3/RSK2 levels were demonstrated in the proband by qPCR and immunoblotting. To our knowledge, this is the first family identified with a submicroscopic duplication including the entire RPS6KA3/RSK2 gene, and our findings suggest that an increased dose of this gene is responsible for a mild form of NS-XLID.

  5. 12 CFR 359.6 - Filing instructions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... requirements, consult 12 CFR 303.244. In the event that the consent of the institution's primary federal... PARACHUTE AND INDEMNIFICATION PAYMENTS § 359.6 Filing instructions. Requests to make excess nondiscriminatory severance plan payments pursuant to § 359.1(f)(2)(v) and golden parachute payments permitted...

  6. 12 CFR 359.6 - Filing instructions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... requirements, consult 12 CFR 303.244. In the event that the consent of the institution's primary federal... PARACHUTE AND INDEMNIFICATION PAYMENTS § 359.6 Filing instructions. Requests to make excess nondiscriminatory severance plan payments pursuant to § 359.1(f)(2)(v) and golden parachute payments permitted...

  7. 12 CFR 359.6 - Filing instructions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... requirements, consult 12 CFR 303.244. In the event that the consent of the institution's primary federal... PARACHUTE AND INDEMNIFICATION PAYMENTS § 359.6 Filing instructions. Requests to make excess nondiscriminatory severance plan payments pursuant to § 359.1(f)(2)(v) and golden parachute payments permitted...

  8. 12 CFR 359.6 - Filing instructions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... requirements, consult 12 CFR 303.244. In the event that the consent of the institution's primary federal... PARACHUTE AND INDEMNIFICATION PAYMENTS § 359.6 Filing instructions. Requests to make excess nondiscriminatory severance plan payments pursuant to § 359.1(f)(2)(v) and golden parachute payments permitted...

  9. 12 CFR 359.6 - Filing instructions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... requirements, consult 12 CFR 303.244. In the event that the consent of the institution's primary federal... PARACHUTE AND INDEMNIFICATION PAYMENTS § 359.6 Filing instructions. Requests to make excess nondiscriminatory severance plan payments pursuant to § 359.1(f)(2)(v) and golden parachute payments permitted...

  10. The Amidohydrolases IAR3 and ILL6 Contribute to Jasmonoyl-Isoleucine Hormone Turnover and Generate 12-Hydroxyjasmonic Acid Upon Wounding in Arabidopsis Leaves*

    PubMed Central

    Widemann, Emilie; Miesch, Laurence; Lugan, Raphaël; Holder, Emilie; Heinrich, Clément; Aubert, Yann; Miesch, Michel; Pinot, Franck; Heitz, Thierry

    2013-01-01

    Jasmonates (JAs) are a class of signaling compounds that mediate complex developmental and adaptative responses in plants. JAs derive from jasmonic acid (JA) through various enzymatic modifications, including conjugation to amino acids or oxidation, yielding an array of derivatives. The main hormonal signal, jasmonoyl-l-isoleucine (JA-Ile), has been found recently to undergo catabolic inactivation by cytochrome P450-mediated oxidation. We characterize here two amidohydrolases, IAR3 and ILL6, that define a second pathway for JA-Ile turnover during the wound response in Arabidopsis leaves. Biochemical and genetic evidence indicates that these two enzymes cleave the JA-Ile signal, but act also on the 12OH-JA-Ile conjugate. We also show that unexpectedly, the abundant accumulation of tuberonic acid (12OH-JA) after wounding originates partly through a sequential pathway involving (i) conjugation of JA to Ile, (ii) oxidation of the JA-Ile conjugate, and (iii) cleavage under the action of the amidohydrolases. The coordinated actions of oxidative and hydrolytic branches in the jasmonate pathway highlight novel mechanisms of JA-Ile hormone turnover and redefine the dynamic metabolic grid of jasmonate conversion in the wound response. PMID:24052260

  11. Structural Basis for Substrate Specificity in Phosphate Binding (beta/alpha)8-Barrels: D-Allulose 6-Phosphate 3-Epimerase from Escherichia coli K-12

    SciTech Connect

    Chan,K.; Fedorov, A.; Almo, S.; Gerlt, J.

    2008-01-01

    Enzymes that share the ({beta}/{alpha})8-barrel fold catalyze a diverse range of reactions. Many utilize phosphorylated substrates and share a conserved C-terminal ({beta}/a)2-quarter barrel subdomain that provides a binding motif for the dianionic phosphate group. We recently reported functional and structural studies of d-ribulose 5-phosphate 3-epimerase (RPE) from Streptococcus pyogenes that catalyzes the equilibration of the pentulose 5-phosphates d-ribulose 5-phosphate and d-xylulose 5-phosphate in the pentose phosphate pathway [J. Akana, A. A. Fedorov, E. Fedorov, W. R. P. Novack, P. C. Babbitt, S. C. Almo, and J. A. Gerlt (2006) Biochemistry 45, 2493-2503]. We now report functional and structural studies of d-allulose 6-phosphate 3-epimerase (ALSE) from Escherichia coli K-12 that catalyzes the equilibration of the hexulose 6-phosphates d-allulose 6-phosphate and d-fructose 6-phosphate in a catabolic pathway for d-allose. ALSE and RPE prefer their physiological substrates but are promiscuous for each other's substrate. The active sites (RPE complexed with d-xylitol 5-phosphate and ALSE complexed with d-glucitol 6-phosphate) are superimposable (as expected from their 39% sequence identity), with the exception of the phosphate binding motif. The loop following the eighth {beta}-strand in ALSE is one residue longer than the homologous loop in RPE, so the binding site for the hexulose 6-phosphate substrate/product in ALSE is elongated relative to that for the pentulose 5-phosphate substrate/product in RPE. We constructed three single-residue deletion mutants of the loop in ALSE, ?T196, ?S197 and ?G198, to investigate the structural bases for the differing substrate specificities; for each, the promiscuity is altered so that d-ribulose 5-phosphate is the preferred substrate. The changes in kcat/Km are dominated by changes in kcat, suggesting that substrate discrimination results from differential transition state stabilization. In both ALSE and RPE, the phosphate

  12. Rational design, synthesis, anti-HIV-1 RT and antimicrobial activity of novel 3-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-1-(piperazin-1-yl)propan-1-one derivatives.

    PubMed

    Chander, Subhash; Wang, Ping; Ashok, Penta; Yang, Liu-Meng; Zheng, Yong-Tang; Murugesan, Sankaranarayanan

    2016-08-01

    In the present study, fifteen novel 3-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-1-(piperazin-1-yl)propan-1-one (6a-o) derivatives were designed as inhibitor of HIV-1 RT using ligand based drug design approach and in-silico evaluated for drug-likeness properties. Designed compounds were synthesized, characterized and in-vitro evaluated for RT inhibitory activity against wild HIV-1 RT strain. Among the tested compounds, four compounds (6a, 6b, 6j and 6o) exhibited significant inhibition of HIV-1 RT (IC50⩽10μg/ml). All synthesized compounds were also evaluated for anti-HIV-1 activity as well as cytotoxicity on T lymphocytes, in which compounds 6b and 6l exhibited significant anti-HIV activity (EC50 values 4.72 and 5.45μg/ml respectively) with good safety index. Four compounds (6a, 6b, 6j and 6o) found significantly active against HIV-1 RT in the in-vitro assay were in-silico evaluated against two mutant RT strains as well as one wild strain. Further, titled compounds were evaluated for in-vitro antibacterial (Escherichia coli, Pseudomonas putida, Staphylococcus aureus and Bacillus cereus) and antifungal (Candida albicans and Aspergillus niger) activities.

  13. Adipic acid–2,4-diamino-6-(4-meth­oxy­phen­yl)-1,3,5-triazine (1/2)

    PubMed Central

    Thanigaimani, Kaliyaperumal; Razak, Ibrahim Abdul; Arshad, Suhana; Jagatheesan, Rathinavel; Santhanaraj, Kulandaisamy Joseph

    2012-01-01

    The asymmetric unit of the title compound, 2C10H11N5O·C6H10O4, consists of a 2,4-diamino-6-(4-meth­oxy­phen­yl)-1,3,5-triazine mol­ecule and one-half mol­ecule of adipic acid which lies about an inversion center. The triazine ring makes a dihedral angle of 12.89 (4)° with the adjacent benzene ring. In the crystal, the components are linked by N—H⋯O and O—H⋯N hydrogen bonds, thus generating a centrosymmetric 2 + 1 unit of triazine and adipic acid mol­ecules with R 2 2(8) motifs. The triazine mol­ecules are connected to each other by N—H⋯N hydrogen bonds, forming an R 2 2(8) motif and a supra­molecular ribbon along the c axis. The 2 + 1 units and the supra­molecular ribbons are further inter­linked by weak N—H⋯O, C—H⋯O and C—H⋯π inter­actions, resulting in a three-dimensional network. PMID:23125724

  14. Crystal structure of 2-amino-1,3-di­bromo-6-oxo-5,6-di­hydro­pyrido[1,2-a]quinoxalin-11-ium bromide monohydrate

    PubMed Central

    Faizi, Md. Serajul Haque; Parashchenko, Yuliia

    2015-01-01

    In the title hydrated salt, C12H8Br2N3O+·Br−·H2O, which was synthesized by the reaction of the pyridine derivative Schiff base N 1,N 4-bis­(pyridine-2-yl­methyl­ene)benzene-1,4-di­amine with bromine, the asymmetric unit contains a 2-amino-1,3-di­bromo-6-oxo-5,6-di­hydro­pyrido[1,2-a]quinoxalin-11-ium cation, with a protonated pyridine moiety, a bromide anion and a water mol­ecule of solvation. The cation is non-planar with the di­bromo-substituted benzene ring, forming dihedral angles of 24.3 (4) and 11.5 (4)° with the fused pyridine and pyrazine ring moieties, respectively. In the crystal, the cations are linked through a centrosymmetric hydrogen-bonded cyclic R 4 2(8) Br2(H2O)2 unit by N—H⋯Br, N—H⋯O and O—H⋯Br hydrogen bonds, forming one-dimensional ribbons extending along b, with the planes of the cations lying parallel to (100). PMID:26594504

  15. 12. Historic American Buildings Survey, Stanley Jones, Photographer July 6, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Historic American Buildings Survey, Stanley Jones, Photographer July 6, 1936, copied from portrait, PORTRAIT OF WILLIAM HENRY 3RD, OWNER OF HENRY GUN FACTORY. - Henry Gun Factory, Belfast, Northampton County, PA

  16. 12 CFR 261b.6 - Public announcement of meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Public announcement of meetings. 261b.6 Section 261b.6 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM RULES REGARDING PUBLIC OBSERVATION OF MEETINGS § 261b.6 Public announcement of meetings....

  17. 12 CFR 27.6 - Substitute monitoring program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Substitute monitoring program. 27.6 Section 27.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FAIR HOUSING HOME LOAN DATA SYSTEM § 27.6 Substitute monitoring program. The recordkeeping provisions of § 27.3 constitute...

  18. 12 CFR 230.6 - Periodic statement disclosures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Periodic statement disclosures. 230.6 Section 230.6 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM TRUTH IN SAVINGS (REGULATION DD) § 230.6 Periodic statement disclosures. (a) General rule. If...

  19. 12 CFR 269.6 - Unfair labor practices.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... discourage membership in any labor organization by discrimination in regard to hire or tenure of employment... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Unfair labor practices. 269.6 Section 269.6... POLICY ON LABOR RELATIONS FOR THE FEDERAL RESERVE BANKS § 269.6 Unfair labor practices. (a) It shall...

  20. Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine

    SciTech Connect

    Kim, Sungkyoon; Kim, David; Pollack, Gary M.; Collins, Leonard B.; Rusyn, Ivan

    2009-07-01

    Trichloroethylene (TCE) is a well-known carcinogen in rodents and concerns exist regarding its potential carcinogenicity in humans. Oxidative metabolites of TCE, such as dichloroacetic acid (DCA) and trichloroacetic acid (TCA), are thought to be hepatotoxic and carcinogenic in mice. The reactive products of glutathione conjugation, such as S-(1,2-dichlorovinyl)-L-cysteine (DCVC), and S-(1,2-dichlorovinyl) glutathione (DCVG), are associated with renal toxicity in rats. Recently, we developed a new analytical method for simultaneous assessment of these TCE metabolites in small-volume biological samples. Since important gaps remain in our understanding of the pharmacokinetics of TCE and its metabolites, we studied a time-course of DCA, TCA, DCVG and DCVG formation and elimination after a single oral dose of 2100 mg/kg TCE in male B6C3F1 mice. Based on systemic concentration-time data, we constructed multi-compartment models to explore the kinetic properties of the formation and disposition of TCE metabolites, as well as the source of DCA formation. We conclude that TCE-oxide is the most likely source of DCA. According to the best-fit model, bioavailability of oral TCE was {approx} 74%, and the half-life and clearance of each metabolite in the mouse were as follows: DCA: 0.6 h, 0.081 ml/h; TCA: 12 h, 3.80 ml/h; DCVG: 1.4 h, 16.8 ml/h; DCVC: 1.2 h, 176 ml/h. In B6C3F1 mice, oxidative metabolites are formed in much greater quantities ({approx} 3600 fold difference) than glutathione-conjugative metabolites. In addition, DCA is produced to a very limited extent relative to TCA, while most of DCVG is converted into DCVC. These pharmacokinetic studies provide insight into the kinetic properties of four key biomarkers of TCE toxicity in the mouse, representing novel information that can be used in risk assessment.

  1. The use of urea dilution for estimation of carcass composition of Holstein steers at 3, 6, 9, and 12 months of age.

    PubMed

    Velazco, J; Morrill, J L; Kropf, D H; Brandt, R T; Harmon, D L; Preston, R L; Clarenburg, R

    1997-01-01

    Every 3 mo for a 2-yr period, two weaned Holstein steer calves (94.5 kg) were randomly assigned to each of four slaughter age groups (3, 6, 9, and 12 mo). Urea dilution was performed before slaughter, and urea space (US) was calculated as total volume and as a percentage of body weight (BW) and empty body weight (EBW). The relationships between US (kg, % EBW and % BW), BW, and EBW and carcass soft tissue composition (protein, fat, moisture, and ash) were studied. One- and two-pool models were fitted using the urea dilution data and the coefficients of those equations (zero time, A + B), and the intercepts of compartments A and B were used to estimate body volume. Body weight and EBW effectively predicted the amount of water, fat, and protein in the carcass soft tissue. Equations expressed in kilograms were more accurate than those expressed as percentages. Urea space overestimated body water, probably because of the fast rate of urea disappearance in plasma. Correlation coefficients between US and carcass soft tissue water (kg) based on the pooled data ranged from .74 at 6 min to .48 at 42 min after infusion. The biexponential models coefficients explained more of the variation of carcass soft tissue composition than US; correlation coefficients using volume B and the soft tissue composition (in kg) with pooled data were .78 (water), .68 (fat), .69 (ash), and .76 (protein). The relationships between A and soft tissue composition were weaker (water .59, fat .51, ash .58 and protein .59). The highest correlation coefficients were obtained when A + B was used for water, fat, ash, and protein (.83, .70, .74 and .81, respectively). Equations combining BW, EBW, and two-model coefficients (A, B, A + B) explained much of the variation of soft tissue composition. No significant benefit was found in using the urea space at various times after infusion over BW or EBW alone to estimate carcass soft tissue composition in Holstein steers.

  2. Absolute frequencies of the {sup 6,7}Li 2S {sup 2}S{sub 1/2}{yields}3S {sup 2}S{sub 1/2} transitions

    SciTech Connect

    Lien, Yu-Hung; Lo, Kuan-Ju; Chen, Jun-Ren; Liu, Yi-Wei; Chen, Hsuan-Chen; Tian, Jyun-Yu; Shy, Jow-Tsong

    2011-10-15

    The measurement of the absolute frequencies of the 2S{yields}3S of atomic lithium is reported. To reduce systematic effects, we employed a frequency-comb-stabilized excitation laser, a weakly collimated atomic beam, and the cascading 2P{yields}2S 670 nm fluorescence as the signal. The transition frequencies, including two isotopes ({sup 6,7}Li), were measured to an accuracy of < 330 kHz. In comparison with the previous GSI Group experiment, the frequency of the 2S{sub 1/2}{yields}3S{sub 1/2} transition of {sup 7}Li is 815 618 181.45(9) MHz, which is improved by a factor of 2. The resultant hyperfine constants of the 3S state and the deduced difference of the nuclear charge radii {delta} from the isotope shift are in good agreement with previous results. Since a more straightforward methodology is adopted, our measurement is less model dependent and serves as an independent investigation of the reported transitions.

  3. Near-UV and blue wavelength excitable Mg{sub 0.6}Ca{sub 2.16}Mo{sub 0.2}W{sub 0.8}O{sub 6}: Eu{sub 0.12}{sup 3+}/Na{sub 0.12}{sup +} high efficiency red phosphors

    SciTech Connect

    Khanna, A.; Dutta, P.S.

    2015-05-15

    Red phosphors with narrow emission around 615 nm (with FWHM~5–10 nm) having chemical compositions of A{sub 0.6}Ca{sub 2.16}Mo{sub 0.2}W{sub 0.8}O{sub 6}: Eu{sub 0.12}{sup 3+}/Na{sub 0.12}{sup +} (A=Mg, Sr) have been found to exhibit the highest luminescence amongst the molybdate–tungstate family when excited by sources in the 380–420 nm wavelength range. Thus they are most suitable for enhancing color rendering index and lowering color temperature in phosphor converted white LEDs (pc-WLEDs) with near-UV/blue LED excitation sources. The excitation band edge in the near UV/blue wavelength in the reported phosphor has been attributed to the coordination environment of the transition metal ion (Mo{sup 6+}, W{sup 6+}) and host crystal structure. Furthermore the quantum efficiency of the phosphors has been enhanced by adjusting activator concentration, suitable compositional alloying using substitutional alkaline earth metal cations and charge compensation mechanisms. - Graphical abstract: The charge transfer excitation of orthorhombic Mg{sub 0.6}Ca{sub 2.16}Mo{sub 0.2}W{sub 0.8}O{sub 6}: Eu{sub 0.12}{sup 3+}/Na{sub 0.12}{sup +} is significantly higher than tetragonal CaMoO{sub 4}: Eu{sup 3+} phosphors making Mg{sub 0.6}Ca{sub 2.16}Mo{sub 0.2}W{sub 0.8}O{sub 6}: Eu{sub 0.12}{sup 3+}/Na{sub 0.12}{sup +} prime candidates for fabrication of warm white phosphor-converted LEDs. - Highlights: • LED excitable Mg{sub 0.6}Ca{sub 2.16}Mo{sub 0.2}W{sub 0.8}O{sub 6}: Eu{sub 0.12}{sup 3+}/Na{sub 0.12}{sup +} phosphors were synthesized. • These phosphors are 10 times more intense than CaMoO{sub 4}: Eu{sup 3+} red phosphors. • Their intensity and efficiency were enhanced by materials optimization techniques. • Such techniques include compositional alloying, charge compensation, etc.

  4. Crystal structure of dimethyl 3,4,5,6-tetra-phenyl-cyclo-hexa-3,5-diene-1,2-di-carboxyl-ate.

    PubMed

    Greenberg, Fred H; Nazarenko, Alexander Y

    2016-07-01

    In the title compound, C34H28O4, the cyclo-hexa-diene ring has a screw-boat conformation with a torsion angle between the double bonds being on average ca 15° [15.2 (3) and -15.3 (3) in the two independent mol-ecules]. All four phenyl rings in both mol-ecules are arranged in a propeller-like conformation. The two mol-ecules exhibit S,R- and R,S- chirality, respectively, and are connected via C-H⋯O inter-molecular inter-actions. In turn, these weakly bound dimers form the mol-ecular crystal. PMID:27555937

  5. (E)-Methyl 2-[(2S,3S,12bR)-3-ethyl-8-meth­oxy-1,2,3,4,6,7,12,12b-octa­hydro­indolo[2,3-a]quinolizin-2-yl]-3-methoxy­acrylate ethanol solvate

    PubMed Central

    Carvalho, Paulo; Furr III, Edward B.; McCurdy, Christopher

    2009-01-01

    In the title compound, C23H30N2O4·C2H6O, the indole derivative has four fused rings, forming an indolo[2-3a]quinolizine system, in which one six-membered ring is directly connected to the indole unit and has a distorted chair conformation. The fourth ring is also a six-membered ring, depicting a regular chair conformation. In the crystal, the mol­ecules are linked by N—H⋯O and O—H⋯N inter­actions, forming a C(7) chain. PMID:21583280

  6. Dynamic compression of dense oxide (Gd3Ga5O12) from 0.4 to 2.6 TPa: Universal Hugoniot of fluid metals

    PubMed Central

    Ozaki, N.; Nellis, W. J.; Mashimo, T.; Ramzan, M.; Ahuja, R.; Kaewmaraya, T.; Kimura, T.; Knudson, M.; Miyanishi, K.; Sakawa, Y.; Sano, T.; Kodama, R.

    2016-01-01

    Materials at high pressures and temperatures are of great current interest for warm dense matter physics, planetary sciences, and inertial fusion energy research. Shock-compression equation-of-state data and optical reflectivities of the fluid dense oxide, Gd3Ga5O12 (GGG), were measured at extremely high pressures up to 2.6 TPa (26 Mbar) generated by high-power laser irradiation and magnetically-driven hypervelocity impacts. Above 0.75 TPa, the GGG Hugoniot data approach/reach a universal linear line of fluid metals, and the optical reflectivity most likely reaches a constant value indicating that GGG undergoes a crossover from fluid semiconductor to poor metal with minimum metallic conductivity (MMC). These results suggest that most fluid compounds, e.g., strong planetary oxides, reach a common state on the universal Hugoniot of fluid metals (UHFM) with MMC at sufficiently extreme pressures and temperatures. The systematic behaviors of warm dense fluid would be useful benchmarks for developing theoretical equation-of-state and transport models in the warm dense matter regime in determining computational predictions. PMID:27193942

  7. Metabolism of triethylenetetramine and 1,12-diamino-3,6,9-triazadodecane by the spermidine/spermine-N(1)-acetyltransferase and thialysine acetyltransferase.

    PubMed

    Hyvönen, Mervi T; Weisell, Janne; Khomutov, Alex R; Alhonen, Leena; Vepsäläinen, Jouko; Keinänen, Tuomo A

    2013-01-01

    Triethylenetetramine (TETA; Syprine; Merck Rahway, NJ), a drug for Wilson's disease, is a copper chelator and a charge-deficient analog of polyamine spermidine. We recently showed that TETA is metabolized in vitro by polyamine catabolic enzyme spermidine/spermine-N(1)-acetyltransferase (SSAT1) and by thialysine acetyltransferase (SSAT2) to its monoacetylated derivative (MAT). The acetylation of TETA is increased in SSAT1-overexpressing mice compared with wild-type mice. However, SSAT1-deficient mice metabolize TETA at the same rate as the wild-type mice, indicating the existence of another N-acetylase respons 2ible for its metabolism in mice. Here, we show that siRNA-mediated knockdown of SSAT2 in HEPG2 cells and in primary hepatocytes from the SSAT1-deficient or wild-type mice reduced the metabolism of TETA to MAT. By contrast, 1,12-diamino-3,6,9-triazadodecane(SpmTrien), a charge-deficient spermine analog, was an extremely poor substrate of human recombinant SSAT2 and was metabolized by SSAT1 in HEPG2 cells and in wild-type primary hepatocytes. Thus, despite the similar structures of TETA and SpmTrien, SSAT2 is the main acetylator of TETA, whereas SpmTrien is primarily acetylated by SSAT1.

  8. Dating of young groundwater using four anthropogenic trace gases (SF6, SF5CF3, CFC-12 and Halon-1301): methodology and first results.

    PubMed

    Bartyzel, Jakub; Rozanski, Kazimierz

    2016-01-01

    A dedicated, GC-based analytical system is presented which allows detection of four anthropogenic trace gases (SF6, SF5CF3, CFC-12 and Halon-1301) in a single water sample, with detection limits and measurement uncertainties sufficiently low to employ them as quantitative indicators of groundwater age. The gases dissolved in water are extracted in the field using the method based on a dynamic head-space concept. In the laboratory, the investigated gases are cryogenically enriched, separated and measured using an electron capture detector. Reproducibility of the analyses is in the order of 2-5 %. The investigated tracers were measured in several production wells located in the recharge area of an intensively exploited aquifer in southern Poland. While the piston-flow ages of groundwater in the investigated wells revealed internal consistency, they appeared to be generally smaller than the ages derived from time series of tritium content in those wells, interpreted by lumped-parameter models. This difference stems mainly from significantly longer travel times of tritium through the unsaturated zone, when compared to the gaseous tracers being used. The results of this study highlight the benefits of using multiple tracing in quantifying timescales of groundwater flow in shallow aquifer systems. PMID:26863003

  9. Dynamic compression of dense oxide (Gd3Ga5O12) from 0.4 to 2.6 TPa: Universal Hugoniot of fluid metals.

    PubMed

    Ozaki, N; Nellis, W J; Mashimo, T; Ramzan, M; Ahuja, R; Kaewmaraya, T; Kimura, T; Knudson, M; Miyanishi, K; Sakawa, Y; Sano, T; Kodama, R

    2016-01-01

    Materials at high pressures and temperatures are of great current interest for warm dense matter physics, planetary sciences, and inertial fusion energy research. Shock-compression equation-of-state data and optical reflectivities of the fluid dense oxide, Gd3Ga5O12 (GGG), were measured at extremely high pressures up to 2.6 TPa (26 Mbar) generated by high-power laser irradiation and magnetically-driven hypervelocity impacts. Above 0.75 TPa, the GGG Hugoniot data approach/reach a universal linear line of fluid metals, and the optical reflectivity most likely reaches a constant value indicating that GGG undergoes a crossover from fluid semiconductor to poor metal with minimum metallic conductivity (MMC). These results suggest that most fluid compounds, e.g., strong planetary oxides, reach a common state on the universal Hugoniot of fluid metals (UHFM) with MMC at sufficiently extreme pressures and temperatures. The systematic behaviors of warm dense fluid would be useful benchmarks for developing theoretical equation-of-state and transport models in the warm dense matter regime in determining computational predictions. PMID:27193942

  10. Dynamic compression of dense oxide (Gd3Ga5O12) from 0.4 to 2.6 TPa: Universal Hugoniot of fluid metals

    NASA Astrophysics Data System (ADS)

    Ozaki, N.; Nellis, W. J.; Mashimo, T.; Ramzan, M.; Ahuja, R.; Kaewmaraya, T.; Kimura, T.; Knudson, M.; Miyanishi, K.; Sakawa, Y.; Sano, T.; Kodama, R.

    2016-05-01

    Materials at high pressures and temperatures are of great current interest for warm dense matter physics, planetary sciences, and inertial fusion energy research. Shock-compression equation-of-state data and optical reflectivities of the fluid dense oxide, Gd3Ga5O12 (GGG), were measured at extremely high pressures up to 2.6 TPa (26 Mbar) generated by high-power laser irradiation and magnetically-driven hypervelocity impacts. Above 0.75 TPa, the GGG Hugoniot data approach/reach a universal linear line of fluid metals, and the optical reflectivity most likely reaches a constant value indicating that GGG undergoes a crossover from fluid semiconductor to poor metal with minimum metallic conductivity (MMC). These results suggest that most fluid compounds, e.g., strong planetary oxides, reach a common state on the universal Hugoniot of fluid metals (UHFM) with MMC at sufficiently extreme pressures and temperatures. The systematic behaviors of warm dense fluid would be useful benchmarks for developing theoretical equation-of-state and transport models in the warm dense matter regime in determining computational predictions.

  11. Dynamic compression of dense oxide (Gd3Ga5O12) from 0.4 to 2.6 TPa: Universal Hugoniot of fluid metals

    DOE PAGES

    Ozaki, N.; Nellis, W. J.; Mashimo, T.; Ramzan, M.; Ahuja, R.; Kaewmaraya, T.; Kimura, T.; Knudson, M.; Miyanishi, K.; Sakawa, Y.; et al

    2016-05-19

    Materials at high pressures and temperatures are of great current interest for warm dense matter physics, planetary sciences, and inertial fusion energy research. Shock-compression equation-of-state data and optical reflectivities of the fluid dense oxide, Gd3Ga5O12 (GGG), were measured at extremely high pressures up to 2.6 TPa (26 Mbar) generated by high-power laser irradiation and magnetically-driven hypervelocity impacts. Above 0.75 TPa, the GGG Hugoniot data approach/reach a universal linear line of fluid metals, and the optical reflectivity most likely reaches a constant value indicating that GGG undergoes a crossover from fluid semiconductor to poor metal with minimum metallic conductivity (MMC). Thesemore » results suggest that most fluid compounds, e.g., strong planetary oxides, reach a common state on the universal Hugoniot of fluid metals (UHFM) with MMC at sufficiently extreme pressures and temperatures. Lastly, the systematic behaviors of warm dense fluid would be useful benchmarks for developing theoretical equation-of-state and transport models in the warm dense matter regime in determining computational predictions.« less

  12. Dating of young groundwater using four anthropogenic trace gases (SF6, SF5CF3, CFC-12 and Halon-1301): methodology and first results.

    PubMed

    Bartyzel, Jakub; Rozanski, Kazimierz

    2016-01-01

    A dedicated, GC-based analytical system is presented which allows detection of four anthropogenic trace gases (SF6, SF5CF3, CFC-12 and Halon-1301) in a single water sample, with detection limits and measurement uncertainties sufficiently low to employ them as quantitative indicators of groundwater age. The gases dissolved in water are extracted in the field using the method based on a dynamic head-space concept. In the laboratory, the investigated gases are cryogenically enriched, separated and measured using an electron capture detector. Reproducibility of the analyses is in the order of 2-5 %. The investigated tracers were measured in several production wells located in the recharge area of an intensively exploited aquifer in southern Poland. While the piston-flow ages of groundwater in the investigated wells revealed internal consistency, they appeared to be generally smaller than the ages derived from time series of tritium content in those wells, interpreted by lumped-parameter models. This difference stems mainly from significantly longer travel times of tritium through the unsaturated zone, when compared to the gaseous tracers being used. The results of this study highlight the benefits of using multiple tracing in quantifying timescales of groundwater flow in shallow aquifer systems.

  13. Extracellular toxicity of 6-hydroxydopamine on PC12 cells.

    PubMed

    Blum, D; Torch, S; Nissou, M F; Benabid, A L; Verna, J M

    2000-04-14

    6-hydroxydopamine (6-OHDA) is usually thought to cross cell membrane through dopamine uptake transporters, to inhibit mitochondrial respiration and to generate intracellular reactive oxygen species. In this study, we show that the anti-oxidants catalase, glutathione and N-acetyl-cysteine are able to reverse the toxic effects of 6-OHDA. These two latter compounds considerably slow down 6-OHDA oxidation in a cell free system suggesting a direct chemical interaction with the neurotoxin. Moreover, desipramine does not protect PC12 cells and 6-OHDA is also strongly toxic towards non-catecholaminergic C6 and NIH3T3 cells. These results thus suggest that 6-OHDA toxicity on PC12 cells mainly involves an extracellular process. PMID:10754220

  14. Using a Checking Account. Grades 6-12.

    ERIC Educational Resources Information Center

    Trey, Frances

    Instructions and exercises on the use of checking accounts are provided for students in grades 6-12. The following topics are included: (1) reasons for opening a checking account; (2) how to open a checking account; (3) how to fill out deposit slips; (4) the elements of a check and how to write a check correctly; (5) checking account rules; (6)…

  15. Very high frequency electron paramagnetic resonance of 2,2,6,6-tetramethyl-1-piperidinyloxy in 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine liposomes: partitioning and molecular dynamics.

    PubMed Central

    Smirnov, A I; Smirnova, T I; Morse, P D

    1995-01-01

    Partitioning and molecular dynamics of 2,2,6,6,-tetramethylpiperedine-1-oxyl (TEMPO) nitroxide radicals in large unilamellar liposomes (LUV) composed from 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine were investigated by using very high frequency electron paramagnetic resonance (EPR) spectroscopy. Experiments carried out at a microwave frequency of 94.3 GHz completely resolved the TEMPO EPR spectrum in the aqueous and hydrocarbon phases. An accurate computer simulation method combined with Levenberg-Marquardt optimization was used to analyze the TEMPO EPR spectra in both phases. Spectral parameters extracted from the simulations gave the actual partitioning of the TEMPO probe between the LUV hydrocarbon and aqueous phases and allowed analysis of picosecond rotational dynamics of the probe in the LUV hydrocarbon phase. In very high frequency EPR experiments, phase transitions in the LUV-TEMPO system were observed as sharp changes in both partitioning and rotational correlation times of the TEMPO probe. The phase transition temperatures (40.5 +/- 0.2 and 32.7 +/- 0.5 degrees C) are in agreement with previously reported differential scanning microcalorimetry data. Spectral line widths were analyzed by using existing theoretical expressions for motionally narrowed nitroxide spectra. It was found that the motion of the small, nearly spherical, TEMPO probe can be well described by anisotropic Brownian diffusion in isotropic media and is not restricted by the much larger hydrocarbon chains existing in ripple structure (P beta') or fluid bilayer structure (L alpha) phases. PMID:7647239

  16. Dating of young groundwater using tritium and gaseous tracers (SF6, SF5CF3, CFC-12, H-1301): case study from southern Poland

    NASA Astrophysics Data System (ADS)

    Rozanski, Kazimierz; Bartyzel, Jakub; Dulinski, Marek; Kuc, Tadeusz; Sliwka, Ireneusz; Mochalski, Pawel; Kania, Jaroslaw; Witczak, Stanislaw

    2013-04-01

    was employed. Apart of well-established tracers such as SF6 and CFC-12, also other trace gases present in the atmosphere (SF5CF3 and H-1301) were tested as age indicators of young groundwater. Time series of tracer concentrations in the sampled boreholes were interpreted with the aid of lumped-parameter models. In parallel, the arrival times of tracers to the selected wells were calculated with the aid of 3D flow and transport model available for the studied groundwater system and compared with the RTD functions obtained from lumped-parameter modeling. Acknowledgements. Partial financial support of this work through GENESIS project (http:/www.thegenesisproject.eu) funded by the European Commission 7FP contract 226536 and through the funds from the Polish Ministry of Science and High Education (projects Nr. N N525 362637 and 11.11.220.01) is kindly acknowledged.

  17. 12 CFR 568.3 - Security program.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Security program. 568.3 Section 568.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITY PROCEDURES § 568.3 Security program. (a) Contents of security program. The security program shall: (1) Establish procedures...

  18. 12 CFR 568.3 - Security program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Security program. 568.3 Section 568.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITY PROCEDURES § 568.3 Security program. (a) Contents of security program. The security program shall: (1) Establish procedures...

  19. 12 CFR 583.3 - Bank.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Bank. 583.3 Section 583.3 Banks and Banking... AND LOAN HOLDING COMPANIES § 583.3 Bank. The term bank means any national bank, state bank, state-chartered savings bank, cooperative bank, or industrial bank, the deposits of which are insured by...

  20. 12 CFR 583.3 - Bank.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Bank. 583.3 Section 583.3 Banks and Banking... AND LOAN HOLDING COMPANIES § 583.3 Bank. The term bank means any national bank, state bank, state-chartered savings bank, cooperative bank, or industrial bank, the deposits of which are insured by...

  1. 12 CFR 583.3 - Bank.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Bank. 583.3 Section 583.3 Banks and Banking... AND LOAN HOLDING COMPANIES § 583.3 Bank. The term bank means any national bank, state bank, state-chartered savings bank, cooperative bank, or industrial bank, the deposits of which are insured by...

  2. 12 CFR 711.3 - Prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Prohibitions. 711.3 Section 711.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS MANAGEMENT OFFICIAL INTERLOCKS § 711.3 Prohibitions. (a) Community. A management official of a depository organization may...

  3. 12 CFR 533.3 - CRA communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true CRA communications. 533.3 Section 533.3 Banks...-RELATED AGREEMENTS § 533.3 CRA communications. (a) Definition of CRA communication. A CRA communication is... any CRA affiliate. (b) Discussions or contacts that are not CRA communications—(1) Timing of...

  4. 12 CFR 533.3 - CRA communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true CRA communications. 533.3 Section 533.3 Banks...-RELATED AGREEMENTS § 533.3 CRA communications. (a) Definition of CRA communication. A CRA communication is... any CRA affiliate. (b) Discussions or contacts that are not CRA communications—(1) Timing of...

  5. 12 CFR 533.3 - CRA communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false CRA communications. 533.3 Section 533.3 Banks...-RELATED AGREEMENTS § 533.3 CRA communications. (a) Definition of CRA communication. A CRA communication is... any CRA affiliate. (b) Discussions or contacts that are not CRA communications—(1) Timing of...

  6. Synthesis of Indeno[1',2':4,5]imidazo[1,2-a]pyridin-11-ones and Chromeno[4',3':4,5]imidazo[1,2-a]pyridin-6-ones through Palladium-Catalyzed Cascade Reactions of 2-(2-Bromophenyl)imidazo[1,2-a]pyridines.

    PubMed

    Zhang, Ju; Zhang, Xinying; Fan, Xuesen

    2016-04-15

    A novel and efficient synthesis of 11H-indeno[1',2':4,5]imidazo[1,2-a]pyridin-11-one, a hybrid structure of indenone with imidazo[1,2-a]pyridine, from the reaction of 2-(2-bromophenyl)imidazo[1,2-a]pyridine with carbon monoxide through palladium-catalyzed CO insertion and C-H bond activation, has been developed. Intriguingly, under similar conditions but in the presence of Cu(OAc)2, the reaction selectively afforded 6H-chromeno[4',3':4,5]imidazo[1,2-a]pyridin-6-one, a hybrid structure of chromenone with imidazo[1,2-a]pyridine, via a more sophisticated cascade process including acetoxylation, deacetylation, CO insertion, and C-H bond activation. PMID:26980482

  7. 12 CFR 269.6 - Unfair labor practices.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Unfair labor practices. 269.6 Section 269.6 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM POLICY ON LABOR RELATIONS FOR THE FEDERAL RESERVE BANKS § 269.6 Unfair labor practices. (a) It shall be an unfair labor practice for a Bank to:...

  8. Improved measurement of the hyperfine structure of the laser cooling level 4f^{12}(^3H_6)5d_{5/2}6s^2 (J=9/2) in {}^{169}_{ 69}{{Tm}}

    NASA Astrophysics Data System (ADS)

    Fedorov, S. A.; Vishnyakova, G. A.; Kalganova, E. S.; Sukachev, D. D.; Golovizin, A. A.; Tregubov, D. O.; Khabarova, K. Yu.; Akimov, A. V.; Kolachevsky, N. N.; Sorokin, V. N.

    2015-12-01

    We report on an improved measurement of the hyperfine constant of the 4f^{12}(^3 H_6)5d_{5/2}6s^2 (J=9/2) excited state of {}^{169}_{ 69}{{Tm}} which is involved in the second-stage laser cooling of Tm. To measure the absolute value of the hyperfine splitting interval, we used Doppler-free frequency modulation saturated absorption spectroscopy of Tm atoms in a vapor cell. The sign of the hyperfine constant was determined independently by spectroscopy of laser-cooled Tm atoms. The hyperfine constant of the level was determined to be A_J=-422.112(32) {MHz} from the energy difference between the two hyperfine sublevels, -2110.56(16) {MHz}. In relation to the saturated absorption measurement, we quantitatively treat contributions of various mechanisms to the line broadening and shift. We consider power broadening in the case when Zeeman sublevels of atomic levels are taken into account. We also discuss the line broadening due to frequency modulation and relative intensities of transitions in saturated absorption experiments.

  9. 12-Acetyl-6-hy-droxy-3,3,9,9-tetra-methyl-furo[3,4-b]pyrano[3,2-h]xanthene-7,11(3H,9H)-dione.

    PubMed

    Ee, Gwendoline Cheng Lian; Teo, Siow Hwa; Kwong, Huey Chong; Mohamed Tahir, Mohamed Ibrahim; Silong, Sidik

    2010-01-01

    The title compound, Artonol B, C(24)H(20)O(7), isolated from the stem bark of Artocarpus kemando, consists of four six-membered rings and one five-membered ring. The tricyclic xanthone ring system is almost planar [maximum deviation 0.115 (5) Å], whereas the pyran-oid ring is in a distorted boat conformation·The furan ring is almost coplanar with the fused aromatic ring, making a dihedral angle of 3.76 (9)°. The phenol ring serves as a intra-molecular hydrogen-bond donor to the adjacent carbonyl group and also acts as an inter-molecular hydrogen-bond acceptor for the methyl groups of adjacent mol-ecules, forming a three-dimensional network in the crystal.

  10. Hepatobiliary disposition of 3alpha,6alpha,7alpha,12alpha-tetrahydroxy-cholanoyl taurine: a substrate for multiple canalicular transporters.

    PubMed

    Megaraj, Vandana; Iida, Takashi; Jungsuwadee, Paiboon; Hofmann, Alan F; Vore, Mary

    2010-10-01

    Tetrahydroxy bile acids become major biliary bile acids in Bsep(-/-) mice and Fxr(-/-) mice fed cholic acid; we characterized disposition of these novel bile acids that also occur in patients with cholestasis. We investigated mouse Mrp2 (mMrp2) and P-glycoprotein [(P-gp) mMdr1a]-mediated transport of a tetrahydroxy bile acid, 6α-OH-taurocholic acid (6α-OH-TC), and its biliary excretion in wild-type and Mrp2(-/-) mice in the presence or absence of N-(4-[2-(1,2,3,4-tetrahydro-6,7-dimethoxy-2-isoquinolinyl)ethyl]-phenyl)-9,10-dihydro-5-methoxy-9-oxo-4-acridine carboxamide (GF120918), a P-gp and breast cancer resistance protein inhibitor. 6α-OH-TC was rapidly excreted into bile of wild-type mice (78% recovery); coinfusion of GF120918 had no significant effect. In Mrp2(-/-) mice, biliary excretion was decreased (52% recovery) and coinfusion of GF120918 further decreased these values (34% recovery). In wild-type, but not Mrp2(-/-), mice, 6α-OH-TC increased bile flow 2.5-fold. Membrane vesicle transport studies of 6α-OH-TC (0.05-0.75 mM) yielded saturation kinetics with a higher apparent affinity for mMrp2 (K(m) = 0.13 mM) than for mMdr1a (K(m) = 0.33 mM); mBsep transported 6α-OH-TC with positive cooperativity (Hill slope = 2.1). Human multidrug resistance-associated protein (MRP) 2 and P-gp also transported 6α-OH-TC but with positive cooperativity (Hill slope = 3.6 and 1.6, respectively). After intraileal administration, the time course of 6α-OH-TC biliary recovery was similar to that of coinfused taurocholate, implying that 6α-OH-TC can undergo enterohepatic cycling. Thus, Mrp2 plays a key role in 6α-OH-TC biliary excretion, whereas P-glycoprotein plays a secondary role; Bsep likely mediates excretion of 6α-OH-TC in the absence of Mrp2 and P-gp. In Bsep(-/-) mice, efficient synthesis of tetrahydroxy bile acids that are Mrp2 and P-gp substrates can explain the noncholestatic phenotype.

  11. DFT studies on a high-energy density cage compound 1, 3, 5, 7, 9, 11-hexo(N(CH3)NO2)-2, 4, 6, 8, 10, 12-hexaazatetracyclo[5, 5, 0, 0, 0] dodecane

    NASA Astrophysics Data System (ADS)

    Li, Xiao-Hong; Yong, Yong-Liang; Zhang, Xian-Zhou

    2014-04-01

    The infrared and Raman spectra, heat of formation (HOF) and thermodynamic properties were investigated by B3LYP/6-31G** method for a new designed polynitro cage compound 1,3,5,7,9,11-hexo(N(CH3)NO2)-2,4,6,8,10,12-hexaazatetracyclo[5,5,0,0,0]dodecane. The detonation velocity (D) and pressure (P) were predicted by the Kamlet-Jacobs equations based on the theoretical density and condensed HOF. The bond dissociation energies and bond orders for the weakest bonds were analysed to investigate the thermal stability of the title compound. The computational result shows that the detonation velocity and pressure of the title compound are superior to those of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), but inferior to those of 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclooctane (HMX) and hexanitrohexaazaisowurtzitane (HNIW). And the analysis of thermal stability shows that the first step of pyrolysis is the rupture of the N7-NO2 bond. The crystal structure obtained by molecular mechanics belongs to the P21 space group, with the lattice parameters Z = 2, a = 11.8246 Å, b = 10.4632 Å, c = 15.9713 Å, ρ = 1.98 g cm-3.

  12. (2-Amino-7-methyl-4-oxidopteridine-6-carboxyl­ato-κ3 O 4,N 5,O 6)aqua­(ethane-1,2-diamine-κ2 N,N′)nickel(II) dihydrate

    PubMed Central

    Baisya, Siddhartha S.; Roy, Parag S.

    2013-01-01

    The NiII atom in the title complex, [Ni(C8H5N5O3)(C2H8N2)(H2O)]·2H2O, is six-coordinated in a distorted octa­hedral geometry by a tridentate 2-amino-7-methyl-4-oxidopteridine-6-carboxyl­ate (pterin) ligand, a bidentate ancillary ethane-1,2-diamine (en) ligand and a water mol­ecule. The pterin ligand forms two chelate rings. The en and pterin ligands are arranged nearly orthogonally [dihedral angle between the mean plane of the en mol­ecule and the pterin ring = 77.1 (1)°]. N—H⋯O, O—H⋯N and O—H⋯O hydrogen bonds link the complex mol­ecules and lattice water mol­ecules into a three-dimensional network. π–π inter­actions are observed between the pyrazine and pyrimidine rings [centroid–centroid distance = 3.437 (2) Å]. PMID:23424441

  13. Three different 2,3-dihydroxybiphenyl-1,2-dioxygenase genes in the gram-positive polychlorobiphenyl-degrading bacterium Rhodococcus globerulus P6.

    PubMed Central

    Asturias, J A; Timmis, K N

    1993-01-01

    Rhodococcus globerulus P6 (previously designated Acinetobacter sp. strain P6, Arthrobacter sp. strain M5, and Corynebacterium sp. strain MB1) is able to degrade a wide range of polychlorinated biphenyl (PCB) congeners. The genetic and biochemical analyses of the PCB catabolic pathway reported here have revealed the existence of a PCB gene cluster--bphBC1D--and two further bphC genes--bphC2 and bphC3--that encode three narrow-substrate-specificity enzymes (2,3-dihydroxybiphenyl dioxygenases) that meta cleave the first aromatic ring. None of the bphC genes show by hybridization homology to each other or to bphC genes in other bacteria, and the three bphC gene products have different kinetic parameters and sensitivities to inactivation by 3-chlorocatechol. This suggests that there exists a wide diversity in PCB meta cleavage enzymes. Images PMID:8335622

  14. Modules of rupture and oxidation resistance of S12.55Al0.6O0.72N3.52 sialon

    NASA Technical Reports Server (NTRS)

    Arias, A.

    1979-01-01

    A Sialon of formula Si2.55Al0.6O0.72N3.52 was made from ball-milled alpha-Si3N4, AIN, and SiO2 by sintering the powder compacts at 1760 C for 4 hours in stagnant nitrogen. This Sialon had an average modulus of rupture ranging from 404 megapascals (58.6 ksi) at room temperature to 254 megapascals (36.8 ksi) at 1400 C. Oxidation tests at 1400 C in air showed it to have a parabolic oxidation rate constant less than or equal to 2.8x10 to the -10th power sq g/cm4 hr, which is smaller than that of any other Si3N4-base ceramic reported in the literature.

  15. Liquid chromatographic resolution of 1-aryl-1,2,3,4-tetrahydroisoquinolines on a chiral stationary phase based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid.

    PubMed

    Lee, Areum; Choi, Hee Jung; Jin, Kab Bong; Hyun, Myung Ho

    2011-07-01

    A liquid chromatographic chiral stationary phase (CSP) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid was applied for the first time to the resolution of biologically important 1-aryl-1,2,3,4-tetrahydroisoquinolines. The unusual resolution of cyclic secondary amino compounds on a chiral crown ether-based CSP was quite successful with the use of a mixture of methanol-acetonitrile-triethylamine at a ratio of 30/70/0.5 (v/v/v) as a mobile phase. From the chromatographic behaviours for the resolution of seven 1-aryl-1,2,3,4-tetrahydroisoquinolines, the steric bulkiness of the 1-phenyl ring at the chiral center of analytes was concluded to play an important role in the chiral recognition.

  16. Three new alkaline beryllium borates LiBeBO3, Li6Be3B4O12, and Li8Be5B6O18 in the ternary phase diagrams Li2O-BeO-B2O3.

    PubMed

    Wang, Shichao; Ye, Ning; Zou, Guohong

    2014-03-01

    The phase diagram in the Li2O-BeO-B2O3 system has been systematically investigated by the methods of visual polythermal analysis, spontaneous crystallization, and X-ray diffraction. Three new alkaline beryllium borates, namely, LiBeBO3, Li6Be3B4O12, and Li8Be5B6O18, were synthesized with molten fluxes based on Li2O-B2O3 solvent in this system. All of the materials are centrosymmetric. The similarity of the fundamental building block of the title compounds has been compared. Thermal analysis and powder XRD studies were applied to determine phase relation and their incongruent melting behavior. The UV-vis diffuse reflectance spectroscopy demonstrated that the UV cutoff edges of the aforementioned materials are all below 200 nm. PMID:24527663

  17. Three new alkaline beryllium borates LiBeBO3, Li6Be3B4O12, and Li8Be5B6O18 in the ternary phase diagrams Li2O-BeO-B2O3.

    PubMed

    Wang, Shichao; Ye, Ning; Zou, Guohong

    2014-03-01

    The phase diagram in the Li2O-BeO-B2O3 system has been systematically investigated by the methods of visual polythermal analysis, spontaneous crystallization, and X-ray diffraction. Three new alkaline beryllium borates, namely, LiBeBO3, Li6Be3B4O12, and Li8Be5B6O18, were synthesized with molten fluxes based on Li2O-B2O3 solvent in this system. All of the materials are centrosymmetric. The similarity of the fundamental building block of the title compounds has been compared. Thermal analysis and powder XRD studies were applied to determine phase relation and their incongruent melting behavior. The UV-vis diffuse reflectance spectroscopy demonstrated that the UV cutoff edges of the aforementioned materials are all below 200 nm.

  18. Preparation of Two New Diasteromeric Chiral Stationary Phases Based on (+)-(18-Crown-6)-2,3,11,12-tetracarboxylic Acid and (R)- or (S)-1-(1-Naphthyl)ethylamine and Chiral Tethering Group Effect on the Chiral Recognition.

    PubMed

    Agneeswari, Rajalingam; Sung, Ji Yeong; Jo, Eun Sol; Jeon, Hee Young; Tamilavan, Vellaiappillai; Hyun, Myung Ho

    2016-01-01

    Two new diastereomeric chiral stationary phases (CSPs) based on (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid as a chiral tethering group and a Π-basic chiral unit such as (R)-1-(1-naphthyl)ethylamine (CSP 1) or (S)-1-(1-naphthyl)ethylamine (CSP 2) were prepared. The two CSPs were applied to the enantiomeric separation of N-(3,5-dinitrobenzoyl)-1-phenylalkylamines and N-(3,5-dinitrobenzoyl)-α-amino acid derivatives using 20% isopropyl alcohol in hexane as a normal mobile phase. To elucidate the effect of the two chiral units on the chiral recognition, the chiral recognition abilities of the two CSPs were compared with each other and with that of a CSP (CSP 3) based on (R)-1-(1-naphthyl)ethylamine. From the chromatographic chiral recognition results, (R)-1-(1-naphthyl)ethylamine and (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid constituting CSP 1 were concluded to show a cooperative ("matched") effect on the chiral recognition while (S)-1-(1-naphthyl)ethylamine and (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid constituting CSP 2 were concluded to show an uncooperative ("mismatched") effect on the chiral recognition. From these results, it was concluded that (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid can be successfully used as a chiral tethering group for the preparation of new CSPs. PMID:27529205

  19. Nanoscale hemispheres in novel mixed-valent uranyl chromate(V,VI), (C3NH10)10[(UO2)13(Cr12(5+)O42)(Cr(6+)O4)6(H2O)6](H2O)6.

    PubMed

    Siidra, Oleg I; Nazarchuk, Evgeny V; Petrunin, Anatoly A; Kayukov, Roman A; Krivovichev, Sergey V

    2012-09-01

    The structure of a novel mixed-valent chromium uranyl compound, (C(3)NH(10))(10)[(UO(2))(13)(Cr(12)(5+)O(42))(Cr(6+)O(4))(6)(H(2)O)(6)](H(2)O)(6) (1), obtained by the combination of a hydrothermal method and evaporation from aqueous solutions with isopropylammonium, contains uranyl chromate hemispheres with lateral dimensions of 18.9 × 18.5 Å(2) and a height of about 8 Å. The hemispheres are centered by a UO(8) hexagonal bipyramid surrounded by six dimers of Cr(5+)O(5) square pyramids, UO(7) pentagonal bipyramids, and Cr(6+)O(4) tetrahedra. The hemispheres are linked into two-dimensional layers so that two adjacent hemispheres are oriented in opposite directions relative to the plane of the layer. From a topological point of view, the hemispheres have the formula U(21)Cr(23) and can be considered as derivatives of nanospherical cluster U(26)Cr(36) composed of three-, four-, and five-membered rings.

  20. (R)-3,4,5-Tride-oxy-5,6-didehydro-1,2-O-(2,2,2-trichloro-ethyl-idene)-α-d-gluco-furan-ose-6,3-carbolactone: a new derivative of α-chloralose.

    PubMed

    Aburto-Luna, Violeta; Meza-León, Rosa-Luisa; Bernès, Sylvain

    2008-01-01

    THE TITLE COMPOUND [SYSTEMATIC NAME: (R)-2-trichloro-methyl-3a,3b,7a,8a-tetra-hydro-5H-pyrano[2',3':4,5]furano[2,3-d][1,3]dioxol-5-one], C(9)H(7)Cl(3)O(5), a triyclic system that contains a central α-d-furan-ose ring cis-fused with a dioxolane ring as well as a δ-lactone ring, exhibits a twisted conformation. The CCl(3) group has an axial orientation. The furan-ose ring approximates an envelope conformation due to the α,β-unsaturated lactone functionality. The asymmetric unit contains two independent mol-ecules with almost identical geometries. PMID:21201764

  1. 40 CFR 721.10079 - Quino[2,3-b]acridine-7, 14-dione, 5,12-dihydro-2,9-dimethyl-, 4-[(17-substituted-3,6,9,12,15...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    .... Requirements as specified in § 721.63 (a)(1), (a)(2)(i), (a)(3), (b) (concentration set at 1 percent), and (c...), (w)(1), and (x)(1). (iii) Release to water. Requirements as specified in § 721.90 (a)(4), (b)(4), and (c)(4) (N=10). (b) Specific requirements. The provisions of subpart A of this part apply to...

  2. Efficient Synthesis of the 2-amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxy-pyrido[1,2-c]pyrimidine-1,3-dione core ring system

    PubMed Central

    Rosen, Jonathan D.; German, Nadezhda; Kerns, Robert J.

    2008-01-01

    An optimized total synthesis of the 2-amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxy-pyrido[1,2-c]pyrimidine-1,3-dione core structure of a new fluoroquinolone-like class of antibacterial agents is described. This synthesis is highlighted by a nearly quantitative ring-closing reaction to form the pyrido[1,2-c]pyrimidine core. This bicyclic ring system serves as a scaffold for a family of biologically active compounds. PMID:20160840

  3. 12 CFR 3.300 - Transitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2017 20 Calendar year 2018 and thereafter 0 (e) Prompt corrective action. For purposes of 12 CFR part 6... Provisions § 3.300 Transitions. (a) Capital conservation and countercyclical capital buffer. (1) From January... notwithstanding the amount of its capital conservation buffer or any applicable countercyclical capital...

  4. Influence of Au nanoparticles on the photoluminescent and electrical properties of Bi{sub 3.6}Eu{sub 0.4}Ti{sub 3}O{sub 12} ferroelectric thin films

    SciTech Connect

    Su, Li; Qin, Ni E-mail: stsbdh@mail.sysu.edu.cn; Xie, Wei; Fu, Jianhui; Bao, Dinghua E-mail: stsbdh@mail.sysu.edu.cn

    2014-07-21

    Au-doped Bi{sub 3.6}Eu{sub 0.4}Ti{sub 3}O{sub 12} (BET) thin films were prepared on fused silica and Pt/Ti/SiO{sub 2}/Si substrates by a chemical solution deposition method. The existence of Au nanoparticles (NPs) has been confirmed by X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscope analysis. Enhanced photoluminescence (PL) of Eu{sup 3+} ions was obtained in a wide range of Au doping level. Role of the Au NPs in the PL enhancement was investigated by means of optical absorption, excitation, and emission spectra, as well as decay lifetime measurements. The results indicated that the intra-4f transition of Eu{sup 3+} ions can be intensively activated by the coupling of the charge transfer band of BET with the {sup 5}D{sub 0} state of Eu{sup 3+} ions. The influence of Au NPs on the PL properties of Eu{sup 3+} ions in the present thin films was attributed to the band bending at Au/BET interface and the localized surface plasma resonance absorption of Au NPs in the visible light region. The dielectric and ferroelectric properties of Au-doped BET thin films were investigated as well.

  5. Marine Bromophenol Derivative 3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol Protects Hepatocytes from Lipid-Induced Cell Damage and Insulin Resistance via PTP1B Inhibition

    PubMed Central

    Luo, Jiao; Wu, Ning; Jiang, Bo; Wang, Lijun; Wang, Shuaiyu; Li, Xiangqian; Wang, Baocheng; Wang, Changhui; Shi, Dayong

    2015-01-01

    3,4-Dibromo-5-(2-bromo-3,4-dihydroxy-6-isopropoxymethyl benzyl)benzene-1,2-diol (HPN) is a bromophenol derivative from the marine red alga Rhodomela confervoides. We have previously found that HPN exerted an anti-hyperglycemic property in db/db mouse model. In the present study, we found that HPN could protect HepG2 cells against palmitate (PA)-induced cell death. Data also showed that HPN inhibited cell death mainly by blocking the cell apoptosis. Further studies demonstrated that HPN (especially at 1.0 μM) significantly restored insulin-stimulated tyrosine phosphorylation of IR and IRS1/2, and inhibited the PTP1B expression level in HepG2 cells. Furthermore, the expression of Akt was activated by HPN, and glucose uptake was significantly increased in PA-treated HepG2 cells. Our results suggest that HPN could protect hepatocytes from lipid-induced cell damage and insulin resistance via PTP1B inhibition. Thus, HPN can be considered to have potential for the development of anti-diabetic agent that could protect both hepatic cell mass and function. PMID:26193288

  6. Hydrothermal synthesis and characterization of a new organically templated three-dimensional open-framework gallium phosphate-phosphite (C 6N 2H 18) 2(C 6N 2H 17)Ga 15(OH) 8(PO 4) 2(HPO 4) 12(HPO 3) 6·2H 2O

    NASA Astrophysics Data System (ADS)

    Zhou, Guangpeng; Yang, Yulin; Fan, Ruiqing; Liu, Xinrong; Hong, Hengwu; Wang, Fuping

    2010-07-01

    Using H 3PO 3 as a phosphorus source and oxalic acid as a reducing agent, the first three-dimensional open-framework gallium phosphate-phosphite formula as (C 6N 2H 18) 2(C 6N 2H 17)Ga 15(OH) 8(PO 4) 2(HPO 4) 12(HPO 3) 6·2H 2O ( 1), has been hydrothermally synthesized in the presence of N,N,N',N'-tetramethylenediamine (TMEDA) as a structure-directing agent. Compound 1 crystallizes in trigonal system with space group P - 3, a = b = 19.046(3) Å, c = 8.3306(17) Å, γ = 120°, V = 2617.1(7) Å 3, and Z = 1. Its 3-D network is based on alternated Ga-centered (GaO 4 tetrahedra, GaO 5 trigonal bipyramids, and GaO 6 octahedra) and P-centered (PO 43-, HPO 42-, and HPO 32-) units. Protonated organic amines and water molecules are located in the 12-membered ring channels.

  7. Biological activity and physicochemical parameters of marine halogenated natural products 2,3,3',4,4',5,5'-heptachloro-1'-methyl-1,2'-bipyrrole and 2,4,6-tribromoanisole.

    PubMed

    Vetter, W; Hahn, M E; Tomy, G; Ruppe, S; Vatter, S; Chahbane, N; Lenoir, D; Schramm, K-W; Scherer, G

    2005-01-01

    Physicochemical parameters (vapor pressure, water solubility, Henry's law constant) and biological activities of two halogenated natural products frequently detected in marine samples and food were determined. Synthetic 2,3,3',4,4',5,5'-heptachloro-1'-methyl-1,2'-bipyrrole (Q1) and 2,4,6-tribromoanisole (TBA) were available in pure form. The physicochemical parameters were in the range of anthropogenic chlorinated compounds of concern. The aqueous solubilities at 25 degrees C (S(w,25)) of Q1 and TBA were 4.6 microg/L and 12,200 microg/L, respectively, whereas subcooled liquid vapor pressures were 0.00168 Pa (Q1) and 0.06562 Pa (TBA) as measured by the gas chromatographic-retention time technique. Q1 was negative by established test systems for the determination of ethoxyresorufin-O-deethylase (EROD) induction and by sulforhodamine B assay. EROD induction potency was at least 10(-7) times lower than that of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). At a relatively high concentration (20 microM), Q1 inhibited specific binding of 2 nM [(3)H]TCDD to the in vitro-expressed human aryl hydrocarbon receptor (AHR) by 18%; lower concentrations showed no effect. Molecular modeling showed that Q1 is nonplanar, consistent with its relatively modest affinity as an AHR ligand. When tested for cell-growth inhibitory/cytocidal activity in human tumor cells, Q1 was only marginally, if at all, active with an IC(50) value >50 microM compared with five to ten times lower IC(50) values for potent cytotoxins tested in the test system used. Furthermore, standard pesticide tests on insecticidal, herbicidal, and fungicidal activity did not provide any significant activity at highest concentrations. For TBA, the results in all tests were comparable with Q1. The SRB assay was also applied to the halogenated natural product 4,6-dibromo-2-(2',4'-dibromo)phenoxyanisole, but no toxic response was found. Although it was apparent that Q1 and TBA had been proven to have relatively low biological

  8. 44 CFR 12.6 - Establishment of advisory committees.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Establishment of advisory committees. 12.6 Section 12.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.6 Establishment of advisory committees....

  9. 44 CFR 12.6 - Establishment of advisory committees.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Establishment of advisory committees. 12.6 Section 12.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.6 Establishment of advisory committees....

  10. 44 CFR 12.6 - Establishment of advisory committees.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Establishment of advisory committees. 12.6 Section 12.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.6 Establishment of advisory committees....

  11. 44 CFR 12.6 - Establishment of advisory committees.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Establishment of advisory committees. 12.6 Section 12.6 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.6 Establishment of advisory committees....

  12. 12 CFR 6.2 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the acquiring insured depository institution or company has sole discretionary authority to exercise... Bank Holding Company Act (12 U.S.C. 1841), and the term controlled shall be construed consistently with the term control. (2) Exclusion for fiduciary ownership. No insured depository institution or...

  13. A 28-day oral gavage toxicity study of 3-monochloropropane-1,2-diol (3-MCPD) in CB6F1-non-Tg rasH2 mice.

    PubMed

    Lee, Byoung-Seok; Park, Sang-Jin; Kim, Yong-Bum; Han, Ji-Seok; Jeong, Eun-Ju; Moon, Kyoung-Sik; Son, Hwa-Young

    2015-12-01

    3-Monochloro-1,2-propanediol (3-MCPD) is a well-known contaminant of foods containing hydrolyzed vegetable protein. However, limited toxicity data are available for the risk assessment of 3-MCPD and its carcinogenic potential is controversial. To evaluate the potential toxicity and determine the dose levels for a 26-week carcinogenicity test using Tg rasH2 mice, 3-MCPD was administered once daily by oral gavage at doses of 0, 25, 50, and 100 mg/kg body weight (b.w.)/day for 28 days to male and female CB6F1-non-Tg rasH2 mice (N = 5 males and females per dose). The standard toxicological evaluations were conducted during the in-life and post-mortem phase. In the 100 mg/kg b.w./day group, 3 males and 1 female died during the study and showed clinical signs such as thin appearance and subdued behavior accompanied by significant decreases in mean b.w. Microscopy revealed tubular basophilia in the kidneys, exfoliated degenerative germ cells in the lumen of the seminiferous tubule of the testes, vacuolation in the brain, axonal degeneration of the sciatic nerve, and cardiomyopathy in the 100, ≥25, ≥50, 100, and 100 mg/kg b.w./day groups, respectively. In conclusion, 3-MCPD's target organs were the kidneys, testes, brain, sciatic nerve, and heart. The "no-observed-adverse-effect level" (NOAEL) of 3-MCPD was ≤25 and 25 mg/kg b.w./day in males and females, respectively. PMID:26434797

  14. Infrared Spectroscopy of C_6D_6-Rg_n(n=1,2)

    NASA Astrophysics Data System (ADS)

    George, Jobin; Yousefi, Mahdi; Rezaei, Mojtaba; McKellar, Bob; Moazzen-Ahmadi, Nasser

    2014-06-01

    Benzene-noble gas complexes were one of the earliest topics of interest in spectroscopic investigation of van der Waals (vdW) complexes. Smalley et al. observed C_6H_6-(He)1,2 vdW complexes in the late 1970s by means of electronic spectroscopy. A recent study on the same species was done by M. Hayashi et al. Here, we present the infrared observation of C_6D_6-Rg_n (n=1,2) with the rare gas being He, Ne, or Ar, in the regions of νb{12} fundamental band of C_6D_6 (˜2289 wn) and the νb{2} + νb{13} combination band (˜2275 wn) which are coupled by a Fermi resonance. The spectra were observed at a resolution of 60 MHz using a tunable optical parametric oscillator to probe a pulsed supersonic-jet expansion from a slit nozzle. In the case of C_6D_6-Rg dimers, the spectra were assigned to a symmetric top with C6v symmetry with the rare gas atom being located on the C6 symmetry axis. To observe C_6D_6-Rg_2 trimers, the nozzle was cooled using a closed-cycle methanol refrigerator and the spectra were simulated with a rotational temperature of 1.3K. The spectra of the C_6D_6-Rg_2 trimers were in agreement with a D6h symmetry structure, where the rare gas atoms are positioned above and below the C_6D_6 plane. Data analysis and observation are presently ongoing. S. M. Beck, M. G. Liverman, D. L. Monts and R. E. Smalley, J. Chem. Phys. 70, 232 (1979). M. Hayashi, Y. Ohshima, Chem. Phys. 419, 131 (2013).

  15. [5-(2-Fur­yl)-6-nitro-1,2,3,5,6,7-hexa­hydro­imidazo[1,2-a]pyridin-8-yl](phen­yl)methanone

    PubMed Central

    Yaqub, Muhammad; Shafiq, Zahid; Qureshi, Ashfaq M.; Najam-ul-Haq, Muhammad

    2009-01-01

    In the title compound, C18H17N3O4, the furyl and phenyl rings are inclined at almost right angles [85.77 (7) and 63.25 (7)°, respectively] to the central imidazo[1,2-a]pyridinyl unit. The structure displays both inter- and intra­molecular N—H⋯O hydrogen bonding. PMID:21577676

  16. 4',4',6',6'-Tetra-chloro-2-(6-methyl-pyridin-2-yl)-1H,2H-spiro-[naphtho-[1,2-e][1,3,2]oxaza-phosphinine-3,2'-[1,3,5,2,4,6]tri-aza-triphosphinine].

    PubMed

    Işıklan, Muhammet; Sonkaya, Omer; Hökelek, Tuncer

    2013-06-01

    The title compound, C17H14Cl4N5OP3, is a spiro-phosphazene derivative with bulky naphthalene and pyridine rings. The phosphazene and the six-membered N/O rings are in flattened-boat and twisted-boat conformations, respectively. The naphthalene ring system and the pyridine ring are oriented at a dihedral angle of 18.06 (8)°. In the crystal, weak π-π stacking between the pyridine rings and between the pyridine rings and the naphthalene ring system [centroid-centroid distances = 3.594 (2) and 3.961 (2) Å, respectively] occur. Weak C-H⋯π inter-actions are also observed. These interactions link the molecules into a three-dimensional supramolecular network. PMID:23795044

  17. Combined molecular docking, molecular dynamics simulation and quantitative structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives as potent anti-HIV drugs

    NASA Astrophysics Data System (ADS)

    Deng, Fangfang; Xie, Meihong; Zhang, Xiaoyun; Li, Peizhen; Tian, Yueli; Zhai, Honglin; Li, Yang

    2014-06-01

    3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine is an antiretroviral agent, which can act against human immunodeficiency virus (HIV) infection, but the mechanism of action of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives remained ambiguous. In this study, multiple linear regression (MLR) was applied to establish a quite reliable model with the squared correlation coefficient (R2) of 0.8079. We also used chemical information descriptors based on the simplified molecular input line entry system (SMILES) to get a better model with R2 of 0.9086 for the training set, and R2 of 0.8031 for the test set. Molecular docking was utilized to provide more useful information between pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives and HIV-1 protease, such as active site, binding mode and important residues. Molecular dynamics simulation was employed to further validate the docking results. This work may lead to a better understanding of the mechanism of action and aid to design novel and more potent anti-HIV drugs.

  18. 12 CFR 367.6 - Causes for exclusion.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Causes for exclusion. 367.6 Section 367.6 Banks... SUSPENSION AND EXCLUSION OF CONTRACTOR AND TERMINATION OF CONTRACTS § 367.6 Causes for exclusion. The FDIC... failed to disclose, pursuant to 12 CFR 366.6, a material fact to the FDIC; (f) The contractor has...

  19. 12 CFR 367.6 - Causes for exclusion.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Causes for exclusion. 367.6 Section 367.6 Banks... SUSPENSION AND EXCLUSION OF CONTRACTOR AND TERMINATION OF CONTRACTS § 367.6 Causes for exclusion. The FDIC... failed to disclose, pursuant to 12 CFR 366.6, a material fact to the FDIC; (f) The contractor has...

  20. 12 CFR 367.6 - Causes for exclusion.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Causes for exclusion. 367.6 Section 367.6 Banks... SUSPENSION AND EXCLUSION OF CONTRACTOR AND TERMINATION OF CONTRACTS § 367.6 Causes for exclusion. The FDIC... failed to disclose, pursuant to 12 CFR 366.6, a material fact to the FDIC; (f) The contractor has...

  1. 12 CFR 367.6 - Causes for exclusion.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Causes for exclusion. 367.6 Section 367.6 Banks... SUSPENSION AND EXCLUSION OF CONTRACTOR AND TERMINATION OF CONTRACTS § 367.6 Causes for exclusion. The FDIC... failed to disclose, pursuant to 12 CFR 366.6, a material fact to the FDIC; (f) The contractor has...

  2. High-Temperature Thermoelectric Properties of the Solid-Solution Zintl Phase Eu11Cd6Sb12-xAsx (x < 3)

    SciTech Connect

    Kazem, Nasrin; Xie, Weiwei; Ohno, Saneyuki; Zevalkink, Alexandra; Miller, Gordon J.; Snyder, G. Jeffrey; Kauzlarich, Susan M.

    2014-02-20

    Zintl phases are compounds that have shown promise for thermoelectric applications. The title solid–solution Zintl compounds were prepared from the elements as single crystals using a tin flux for compositions x = 0, 1, 2, and 3. Eu11Cd6Sb12–xAsx (x < 3) crystallize isostructurally in the centrosymmetric monoclinic space group C2/m (no. 12, Z = 2) as the Sr11Cd6Sb12 structure type (Pearson symbol mC58). Efforts to make the As compositions for x exceeding ~3 resulted in structures other than the Sr11Cd6Sb12 structure type. Single-crystal X-ray diffraction indicates that As does not randomly substitute for Sb in the structure but is site specific for each composition. The amount of As determined by structural refinement was verified by electron microprobe analysis. Electronic structures and energies calculated for various model structures of Eu11Cd6Sb10As2 (x = 2) indicated that the preferred As substitution pattern involves a mixture of three of the six pnicogen sites in the asymmetric unit. In addition, As substitution at the Pn4 site opens an energy gap at the Fermi level, whereas substitution at the other five pnicogen sites remains semimetallic with a pseudo gap. Thermoelectric properties of these compounds were measured on hot-pressed, fully densified pellets. Samples show exceptionally low lattice thermal conductivities from room temperature to 775 K: 0.78–0.49 W/mK for x = 0; 0.72–0.53 W/mK for x = 1; and 0.70–0.56 W/mK for x = 2. Eu11Cd6Sb12 shows a high p-type Seebeck coefficient (from +118 to 153 μ V/K) but also high electrical resistivity (6.8 to 12.8 mΩ·cm). The value of zT reaches 0.23 at 774 K. The properties of Eu11Cd6Sb12–xAsx are interpreted in discussion with the As site substitution.

  3. Thermodynamic and Neutron Scattering Study of the Spin-1/2 Kagome Antiferromagnet ZnCu3(OH)6Cl2: A Quantum Spin Liquid System

    NASA Astrophysics Data System (ADS)

    Han, Tianheng

    New physics, such as a quantum spin liquid, can emerge in systems where quantum fluctuations are enhanced due to reduced dimensionality and strong frustration . The realization of a quantum spin liquid in two-dimensions would represent a new state of matter. It is believed that spin liquid physics plays a role in the phenomenon of high-Tc superconductivity, and the topological properties of the spin liquid state may have applications in the field of quantum information. The Zn-paratacamite family, ZnxCu4-- x(OH)6Cl2 for x > 0.33, is an ideal system to look for such an exotic state in the form of antiferromagnetic Cu 2 + kagome planes. The x = 1 end member, named herbertsmithite, has shown promising spin liquid properties from prior studies on powder samples. Here we show a new synthesis by which high-quality centimeter-sized single crystals of Znparatacamite have been produced for the first time. Neutron and synchrotron xray diffraction experiments indicate no structural transition down to T = 2 K. The magnetic susceptibility both perpendicular and parallel to the kagome plane has been measured for the x = 1 sample. A small, temperature-dependent anisotropy has been observed, where chi z / chip > 1 at high temperatures and chiz / chip < 1 at low temperatures. Fits of the high-temperature data to a Curie-Weiss model also reveal anisotropies for thetacw's and g-factors. By comparing with theoretical calculations, the presence of a small easy-axis exchange anisotropy can be deduced as a primary perturbation to the dominant Heisenberg nearest neighbor interaction. These results have great bearing on the interpretation of theoretical calculations based on the kagome Heisenberg antiferromagnet model to the experiments on ZnCu3(OH) 6Cl2. Specific heat measurements down to dilution temperatures and under strong applied magnetic fields show a superlinear temperature dependence with a finite linear term. Most importantly, we present neutron scattering measurements of the

  4. 3-Methyl-1,2,3,4,5,6,1′,2′,3′,4′-deca­hydro­spiro­[benz[f]isoquinoline-1,2′-naphthalen]-1′-one

    PubMed Central

    Siaka, Sohro; Soldatenkov, Anatoly T.; Malkova, Anastasia V.; Sorokina, Elena A.; Khrustalev, Victor N.

    2012-01-01

    The title compound, C23H23NO, is the product of a tandem transformation of the double Mannich base bis­(1-oxo-1,2,3,4-tertrahydro-2-naphtho­ylmeth­yl)amine hydro­chloride in HBr solution upon heating. The tetra­hydro­pyridine ring has a non-symmetrical half-chair conformation, whereas the cyclo­hexa­diene and cyclo­hexene rings adopt non-symmetrical half-boat conformations. The dihedral angle between the planes of the terminal benzene rings is 62.85 (6)°. The N atom has a trigonal–pyramidal geometry [sum of the bond angles = 332.4 (3)°]. In the crystal, mol­ecules form [001] chains via weak non-classical C—H⋯N hydrogen bonds. The chains are stacked along the b axis. PMID:23284532

  5. Discovery of 1-{4-[3-fluoro-4-((3s,6r)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone (GNE-3500): a potent, selective, and orally bioavailable retinoic acid receptor-related orphan receptor C (RORc or RORγ) inverse agonist.

    PubMed

    Fauber, Benjamin P; René, Olivier; Deng, Yuzhong; DeVoss, Jason; Eidenschenk, Céline; Everett, Christine; Ganguli, Arunima; Gobbi, Alberto; Hawkins, Julie; Johnson, Adam R; La, Hank; Lesch, Justin; Lockey, Peter; Norman, Maxine; Ouyang, Wenjun; Summerhill, Susan; Wong, Harvey

    2015-07-01

    Retinoic acid receptor-related orphan receptor C (RORc, RORγ, or NR1F3) is a nuclear receptor that plays a major role in the production of interleukin (IL)-17. Considerable efforts have been directed toward the discovery of selective RORc inverse agonists as potential treatments of inflammatory diseases such as psoriasis and rheumatoid arthritis. Using the previously reported tertiary sulfonamide 1 as a starting point, we engineered structural modifications that significantly improved human and rat metabolic stabilities while maintaining a potent and highly selective RORc inverse agonist profile. The most advanced δ-sultam compound, GNE-3500 (27, 1-{4-[3-fluoro-4-((3S,6R)-3-methyl-1,1-dioxo-6-phenyl-[1,2]thiazinan-2-ylmethyl)-phenyl]-piperazin-1-yl}-ethanone), possessed favorable RORc cellular potency with 75-fold selectivity for RORc over other ROR family members and >200-fold selectivity over 25 additional nuclear receptors in a cell assay panel. The favorable potency, selectivity, in vitro ADME properties, in vivo PK, and dose-dependent inhibition of IL-17 in a PK/PD model support the evaluation of 27 in preclinical studies. PMID:26061388

  6. Folding model calculations for 6He+12C elastic scattering

    NASA Astrophysics Data System (ADS)

    Awad, A. Ibraheem

    2016-03-01

    In the framework of the double folding model, we used the α+2n and di-triton configurations for the nuclear matter density of the 6He nucleus to generate the real part of the optical potential for the system 6He+12C. As an alternative, we also use the high energy approximation to generate the optical potential for the same system. The derived potentials are employed to analyze the elastic scattering differential cross section at energies of 38.3, 41.6 and 82.3 MeV/u. For the imaginary part of the potential we adopt the squared Woods-Saxon form. The obtained results are compared with the corresponding measured data as well as with available results in the literature. The calculated total reaction cross sections are investigated and compared with the optical limit Glauber model description.

  7. Heterometallic aggregates of copper(I) with metalloligand Sn(edt)2 (edt = ethane-1,2-dithiolate): syntheses and structures of [Sn(edt)2Cl(mu-I)(mu3-I)(CuPPh3)3], [Sn(edt)2(mu-Br)2(mu3-Br)2(CuPPh3)4], and [{Sn(edt)2}3(mu-OH)3Cu5(PPh3)8][PF6]2.

    PubMed

    Han, Yan-Gong; Xu, Chao; Duan, Taike; Wu, Fang-Hui; Zhang, Qian-Feng; Leung, Wa-Hung

    2009-09-21

    The treatment of a slurry of an equimolar mixture of [Sn(edt)(2)] (edt = ethane-1,2- dithiolate) and [Et(4)N]Cl.xH(2)O with CuI in the presence of PPh(3) gave a tetranuclear compound, [Sn(edt)(2)Cl(mu-I)(mu(3)-I)(CuPPh(3))(3)] (1), which consists of a rectangular-pyramidal [Sn(edt)(2)Cl](-) moiety ligated by three [Cu(PPh(3))](+) fragments via the sulfur atoms of the edt(2-) ligands. The treatment of a slurry of [Sn(edt)(2)] and excess [Et(4)N]Br with [Cu(MeCN)(4)][PF(6)] in the presence of PPh(3) afforded a pentanuclear compound, [Sn(edt)(2)(mu-Br)(2)(mu(3)-Br)(2)(CuPPh(3))(4)] (2), which comprises two [(CuPPh(3))(2)(mu-Br)](+) fragments symmetrically ligating an octahedral trans-[Sn(edt)(2)Br(2)](2-) moiety via the sulfur and bromide atoms. Reaction of [Sn(edt)(2)] with [Cu(MeCN)(4)][PF(6)] and PPh(3) in a mixed MeCN/CH(2)Cl(2) solution yielded a novel octanuclear compound, [{Sn(edt)(2)}(3)(mu-OH)(3)Cu(5)(PPh(3))(8)][PF(6)](2) (3), which may be described as a triangular [{Sn(edt)(2)}(3)(mu-OH)(3)](3-) core chelated by three [Cu(PPh(3))(2)](+) species and capped by two [Cu(PPh(3))](+) species. The luminescent properties of compounds 1, 2, and 3 were investigated in a CH(2)Cl(2) solution at room temperature. Upon excitation at lambda > 360 nm, these compounds are luminescent in CH(2)Cl(2) solution with emissions having maxima at 422, 515, and 494 nm, respectively. PMID:19746999

  8. Enhancement of α5-Containing Gamma-Aminobutyric Acid TypeAReceptors by the Nonimmobilizer 1,2-Dichlorohexafluorocyclobutane (F6) is Abolished by the β3(N265M) Mutation

    PubMed Central

    Burkat, Paul M.; Lor, Chong; Perouansky, Misha; Pearce, Robert A.

    2014-01-01

    Background Modulation of γ-aminobutyric acid type A receptors (GABAARs) by general anesthetics may contribute to their ability to produce amnesia. Receptors containing α5 subunits, which mediate tonic and slow synaptic inhibition, are co-localized with β3 and γ2 subunits in dendritic layers of the hippocampus and are sensitive to low (amnestic) concentrations of anesthetics. Since α5 and β3 subunits influence performance in hippocampus-dependent learning tasks in the presence and absence of general anesthetics, and the experimental inhaled drug 1,2-dichlorohexafluorocyclobutane (F6) impairs hippocampus-dependent learning, we hypothesized that F6 would modulate receptors that incorporate α5 and β3 subunits. We hypothesized further that the β3(N265M) mutation, which controls receptor modulation by general anesthetics, would similarly influence modulation by F6. Methods Using whole-cell electrophysiological recording techniques, we tested the effects of F6 at concentrations ranging from 4 μM to 16 μM on receptors expressed in human embryonic kidney293 cells. We measured drug modulation of wild type α5β3 and α5β3γ2L GABAARs, and receptors harboring the β3(N265M) mutation. We also tested the effects of F6 on α1β2γ2L receptors, which were reported previously to be insensitive to this drug when expressed in Xenopus oocytes. Results F6 enhanced the responses of wild type α5β3γ2L but not α1β2γ2L receptors to low concentrations of GABA in a concentration-dependent manner. Receptors that incorporated the mutant β3(N265M) subunit were insensitive to F6. When applied together with a high concentration of GABA, F6 blocked currents through α5β3 but not α5β3γ2L receptors. F6 did not alter deactivation of α5β3γ2L receptors after brief, high concentration pulses of GABA. Conclusions The nonimmobilizer F6 modulates GABAARs in a manner that depends on subunit composition and on mode of receptor activation by GABA, supporting a possible role for α5

  9. Crystal structure of 6,7-dihy­droxy-6,7-di­hydro-3H-imidazo[1,2-a]purin-9(5H)-one

    PubMed Central

    Guo, Wei; Li, Cheng-Xun; Lv, Jie; Wang, Jing

    2016-01-01

    The title purine derivative, C7H7N5O3, is an adduct of guanine with glyoxal. In the mol­ecule, the di­hydro­imidazole ring adopts a twisted conformation on the C—C bond, and the two hydroxyl groups lie on opposite sides of the mean plane of the ring. In the crystal, the mol­ecules are linked by N—H⋯O, O—H⋯N and N—H⋯N hydrogen bonds forming a three-dimensional framework. The crystal packing is reinforced by C—H⋯O hydrogen bonds and by offset π–π stacking of the purine ring systems of inversion related mol­ecules [inter­centroid distance = 3.4839 (12) Å]. PMID:27536400

  10. 6. VIEW OF THREE BEARS LAKE, SHOWING WASHED UP 12' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW OF THREE BEARS LAKE, SHOWING WASHED UP 12' x 12' DAM SUPPORT TIMBERS, LOOKING NORTHEAST FROM SOUTH SIDE OF LAKE - Three Bears Lake & Dams, North of Marias Pass, East Glacier Park, Glacier County, MT

  11. Spectroscopic characterization and molecular structure of 3,14-dimethyl-2,6,13,17-tetraazapentacyclo[16.4.0.1(2,17).1(6,13).0(7,12)]tetracosane.

    PubMed

    Moon, Dohyun; Hong, Yong Pyo; Choi, Jong Ha

    2016-09-01

    Constrained cyclam derivatives have been found to exhibit anti-HIV effects. The strength of binding to the CXCR4 receptor correlates with anti-HIV activity. The conformation of the macrocyclic compound is very important for co-receptor recognition. Therefore, knowledge of the conformation and crystal packing of macrocycles has become important in developing new highly effective anti-HIV drugs. Structural modifications of N-functionalized polyaza macrocyclic compounds have been achieved using various methods. A new synthesis affording single crystals of the title tetraazapentacyclo[16.4.0.1(2,17).1(6,13).0(7,12)]tetracosane macrocycle, C22H40N4, is reported. Formaldehyde reacts readily at room temperature with the tetraazatricyclo[16.4.0.0(2,17)]docosane precursor to yield a macropolycycle containing two five-membered rings. Characterization by elemental, spectroscopic and single-crystal X-ray diffraction analyses shows that the asymmetric unit contains half of a centrosymmetric molecule. The molecular structure shows a trans conformation for the two methylene bridges owing to molecular symmetry. The crystal structure is stabilized by intramolecular C-H...N hydrogen bonds. NMR and IR spectroscopic properties support the methylene-bridged macrocyclic structure. PMID:27585935

  12. Corner sharing tetrahedral network in Co(3)(HAT)[N(CN)(2)](6)(OH(2))(2) (HAT = 1,4,5,8,9,12-hexaazatriphenylene).

    PubMed

    Marshall, Shireen R; Rheingold, Arnold L; Dawe, Louise N; Shum, William W; Kitamura, Chitoshi; Miller, Joel S

    2002-07-15

    We report a trinuclear Co(II) complex containing bridging dicyanamides and a tris-chelated HAT, which possesses approximately 37% void space. The magnetic exchange pathways appear in the structure as a corner sharing tetrahedral network. The compound crystallizes in the monoclinic space group P2(1)/c [a = 13.655(3) A, b = 15.189(3) A, c = 22.367(4) A, beta = 114.100(2) degrees, V = 4234.5(14) A(3), Z = 4, R(F(o)) = 0.0823]. The magnetic data were fit to an S = 3/2 model for systems dominated by zero-field splitting effects with g = 2.01 and D = 38.9 cm(-1). PMID:12099860

  13. Poly[[aqua­(μ5-3,4,5,6-tetra­carb­oxy­cyclo­hexane-1,2-dicarboxyl­ato)strontium] monohydrate

    PubMed Central

    Cheng, Pei-Chi; Zhan, Jun-Xiang; Wu, Cheng-You; Lin, Chia-Her

    2011-01-01

    In the title compound, {[Sr(C12H10O12)(H2O)]·H2O}n, the SrII ion is coordinated by six O atoms of five symmetry-related 3,4,5,6-tetra­carb­oxy­cyclo­hexane-1,2-dicarboxyl­ate ligands and one water mol­ecule in a slightly distorted monocapped trigonal–prismatic environment. The ligands bridge the SrII ions, forming a two-dimensional structure. In the crystal, O—H⋯O hydrogen bonds further connect the structure into a three-dimensional network. The H atoms of two of the carboxyl groups were refined as half-occupancy. PMID:22199657

  14. 12 CFR 208.6 - Establishment and maintenance of branches.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the Board's Regulation K (12 CFR part 211). (3) Public notice of branch applications. (i) Location of... application in accordance with the Board's Rules of Procedure, located at 12 CFR 262.3, and must comply with... of the Rules of Procedure (12 CFR 262.3). (ii) Contents of notice. The newspaper notice referred...

  15. 12 CFR 208.6 - Establishment and maintenance of branches.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the Board's Regulation K (12 CFR part 211). (3) Public notice of branch applications. (i) Location of... application in accordance with the Board's Rules of Procedure, located at 12 CFR 262.3, and must comply with... of the Rules of Procedure (12 CFR 262.3). (ii) Contents of notice. The newspaper notice referred...

  16. 12 CFR 705.6 - Community needs plan.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Community needs plan. 705.6 Section 705.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS COMMUNITY DEVELOPMENT REVOLVING LOAN PROGRAM FOR CREDIT UNIONS § 705.6 Community needs plan. (a) The credit...

  17. 12 CFR 704.6 - Credit risk management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Credit risk management. 704.6 Section 704.6... CREDIT UNIONS § 704.6 Credit risk management. (a) Policies. A corporate credit union must operate according to a credit risk management policy that is commensurate with the investment risks and...

  18. 12 CFR 704.6 - Credit risk management.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Credit risk management. 704.6 Section 704.6... CREDIT UNIONS § 704.6 Credit risk management. (a) Policies. A corporate credit union must operate according to a credit risk management policy that is commensurate with the investment risks and...

  19. 12 CFR 543.6 - Completion of organization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... prescribed by the Office. (2) Organization meeting. Promptly upon receipt of a charter, the temporary... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Completion of organization. 543.6 Section 543.6... ASSOCIATIONS-INCORPORATION, ORGANIZATION, AND CONVERSION Organization § 543.6 Completion of organization....

  20. 12 CFR 508.6 - Initiation of hearing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Initiation of hearing. 508.6 Section 508.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.6 Initiation of hearing. (a) Within 10 days of the...

  1. 12 CFR 707.6 - Periodic statement disclosures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Periodic statement disclosures. 707.6 Section 707.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS TRUTH IN SAVINGS § 707.6 Periodic statement disclosures. (a) Rule when statement and crediting periods...

  2. 12 CFR 722.6 - Professional association membership; competency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Professional association membership; competency. 722.6 Section 722.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS APPRAISALS § 722.6 Professional association membership; competency. (a) Membership...

  3. 12 CFR 722.6 - Professional association membership; competency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 6 2011-01-01 2011-01-01 false Professional association membership; competency. 722.6 Section 722.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS APPRAISALS § 722.6 Professional association membership; competency. (a) Membership...

  4. 12 CFR 705.6 - Community needs plan.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Community needs plan. 705.6 Section 705.6 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS COMMUNITY DEVELOPMENT REVOLVING LOAN PROGRAM FOR CREDIT UNIONS § 705.6 Community needs plan. (a) The credit...

  5. 12 CFR 552.6-1 - Board of directors.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 6 2013-01-01 2012-01-01 true Board of directors. 552.6-1 Section 552.6-1...-INCORPORATION, ORGANIZATION, AND CONVERSION § 552.6-1 Board of directors. (a) General powers and duties. The business and affairs of the association shall be under the direction of its board of directors. The...

  6. 12 CFR 552.6-1 - Board of directors.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 6 2014-01-01 2012-01-01 true Board of directors. 552.6-1 Section 552.6-1...-INCORPORATION, ORGANIZATION, AND CONVERSION § 552.6-1 Board of directors. (a) General powers and duties. The business and affairs of the association shall be under the direction of its board of directors. The...

  7. 6 CFR 13.12 - Notice of hearing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Notice of hearing. 13.12 Section 13.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.12 Notice of hearing. (a) When the ALJ receives the Complaint and answer, the ALJ will promptly serve...

  8. 6 CFR 13.12 - Notice of hearing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Notice of hearing. 13.12 Section 13.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY PROGRAM FRAUD CIVIL REMEDIES § 13.12 Notice of hearing. (a) When the ALJ receives the Complaint and answer, the ALJ will promptly serve...

  9. 6 CFR 7.12 - Violations of classified information requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Violations of classified information requirements. 7.12 Section 7.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION Administration § 7.12 Violations of classified...

  10. 6 CFR 7.12 - Violations of classified information requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Violations of classified information requirements. 7.12 Section 7.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION Administration § 7.12 Violations of classified...

  11. 6 CFR 7.12 - Violations of classified information requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Violations of classified information requirements. 7.12 Section 7.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLASSIFIED NATIONAL SECURITY INFORMATION Administration § 7.12 Violations of classified...

  12. 6 CFR 5.12 - Other rights and services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Other rights and services. 5.12 Section 5.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY DISCLOSURE OF RECORDS AND INFORMATION Freedom of Information Act § 5.12 Other rights and services. Nothing in this subpart shall...

  13. 12 CFR 367.6 - Causes for exclusion.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... between competitors, allocation of customers between competitors, and bid rigging, or conspiracy to do the... failed to disclose, pursuant to 12 CFR 366.6, a material fact to the FDIC; (f) The contractor has failed... under 12 CFR 366.6; (g) The contractor has miscertified its status as a minority and/or woman...

  14. A model of human sleep-related growth hormone secretion in dogs: effects of 3, 6, and 12 hours of forced wakefulness on plasma growth hormone, cortisol, and sleep stages.

    PubMed

    Takahashi, Y; Ebihara, S; Nakamura, Y; Takahashi, K

    1981-07-01

    Twenty-four canine GH (cGH) and cortisol secretion patterns associated with sleep stages were studied in 10 male adult dogs. Plasma samples were obtained at 30- or 15-min intervals via an indwelling catheter. Under baseline conditions, all dogs showed irregular polyphasic sleep, and the episodic cGH secretion had no apparent relationship with sleep or the light-dark cycle. Five dogs were subjected to regular sleep-wake cycles; 3, 6, and 12 h of forced wakefulness (FW) were repeated at 3-, 6-, and 12-h intervals (recovery sleep periods), respectively. Peak cGH secretion (mean +/- SD, 6.4 ng/ml +/- 2.4) occurred soon after recovery sleep onset in 25 of 40 total recovery periods. The incidence of sleep-onset cGH peaks and cGH secretion during the first hour of recovery sleep significantly increased with the length of the preceding FW, but were not affected by the time of day. Delta wave sleep increased during this hour, suggesting a possible correlation with the sleep-onset cGH peak. During the first 3 h of recovery after 6 and 12 h of FW, cGH secretion was significantly enhanced, but cortisol was not. Considering the characteristics of human sleep-related GH secretion, we suggest that this peak cGH secretion represents a model of human GH secretion. Possibly, a close association of cGH secretion with sleep is concealed under the baseline condition and uncovered by inducing longer sleep-wake cycles in dogs. No circadian cortisol variation was detected under the baseline or the experimental conditions. PMID:7238408

  15. The genes for the {alpha}-type HC3 (PMSA2) and {beta}-type HC5 (PMSB1) subunits of human proteasomes map to chromosomes 6q27 and 7p12-p13 by fluorescence in situ hybridization

    SciTech Connect

    Okumura, Katsuzumi; Nogami, Masahiro; Taguchi, Hiroshi

    1995-05-20

    The authors have determined the locations of the genes for the two subunits, HC3 and HC5, by fluorescence in situ hybridization (FISH). Chromosome spreads were obtained from phytohemagglutinin-stimulated blood lymphocytes of a healthy donor after thymidine synchronization and bromodeoxyuridine incorporation by the method of Takahashi et al. Genomic DNA fragments of HC3 (4.3 kb, including exons 3, 4, and 5) and HC5 (7.5 kb including exons 1 and 2) (11) were labeled with biotin-16-dUTP by nick-translation. In situ hybridization was performed according to Lichter et al. in the presence of COT-1 DNA as a competitor. Hybridized probe was detected with FITC-conjugated avidin without further signal amplification. Comparison of the fluorescence signals and the banding patterns of the chromosomes indicated that the HC3 and HC5 genes were located on chromosome band 6q27 and 7p12-p13, respectively.

  16. The Mars 6 Landing, 12th March 1974

    NASA Astrophysics Data System (ADS)

    Harvey, B.

    The Soviet Union sent five landers to Mars: 2MV3 in 1962; Mars 2 and 3 in 1971 and Mars 6 and 7 in 1973. Influenced by astrobiologist Gavril Tikhov, early Soviet designers believed that it would be possible to reach the surface of Mars using large parachutes. When the atmosphere was found to be much thinner than anticipated, the landers were redesigned to incorporate rockets. The Mars 2 and 3 missions were impeded by a poor level of navigational knowledge, making it difficult to achieve precise entry trajectories for the subsequent touchdowns. Despite that, Mars 3 achieved the first soft landing on Mars in 1971 and a brief surface transmission. Two years later, the Soviet Union achieved the first temperature and pressure profile of the atmosphere of Mars down to the surface when Mars 6 landed in the Mare Erythraeum on 12th March 1974. Because of internal debates within the Soviet space programme and the nature of news management at the time, the achievement of Mars 6 has been obscured.

  17. 50 CFR 12.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 50 Wildlife and Fisheries 1 2010-10-01 2010-10-01 false Definitions. 12.3 Section 12.3 Wildlife... FORFEITURE PROCEDURES General Provisions § 12.3 Definitions. (a) As used in this part: (1) Attorney General... price at which the seized property or similar property is freely offered for sale at the time and...

  18. 7 CFR 12.3 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Applicability. 12.3 Section 12.3 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.3... actions and determinations regarding wetlands and converted wetlands. Actions taken and...

  19. 7 CFR 12.3 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Applicability. 12.3 Section 12.3 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.3..., 1990, for certain actions and determinations regarding wetlands and converted wetlands. Actions...

  20. 7 CFR 12.3 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Applicability. 12.3 Section 12.3 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.3..., 1990, for certain actions and determinations regarding wetlands and converted wetlands. Actions...

  1. 7 CFR 12.3 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Applicability. 12.3 Section 12.3 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.3..., 1990, for certain actions and determinations regarding wetlands and converted wetlands. Actions...

  2. 7 CFR 12.3 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Applicability. 12.3 Section 12.3 Agriculture Office of the Secretary of Agriculture HIGHLY ERODIBLE LAND AND WETLAND CONSERVATION General Provisions § 12.3... actions and determinations regarding wetlands and converted wetlands. Actions taken and...

  3. 44 CFR 12.3 - Policy.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Policy. 12.3 Section 12.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.3 Policy. In determining whether an advisory committee should be...

  4. 44 CFR 12.3 - Policy.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Policy. 12.3 Section 12.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.3 Policy. In determining whether an advisory committee should be...

  5. 44 CFR 12.3 - Policy.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Policy. 12.3 Section 12.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.3 Policy. In determining whether an advisory committee should be...

  6. 44 CFR 12.3 - Policy.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Policy. 12.3 Section 12.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL ADVISORY COMMITTEES § 12.3 Policy. In determining whether an advisory committee should be...

  7. 45 CFR 12.3 - General policies.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.3 General policies. (a) It is the policy of the Department to foster and assure maximum utilization of surplus real property for public health purposes, including... 45 Public Welfare 1 2013-10-01 2013-10-01 false General policies. 12.3 Section 12.3 Public...

  8. FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.

    PubMed

    Galfré, Elena; Pitt, Samantha J; Venturi, Elisa; Sitsapesan, Mano; Zaccai, Nathan R; Tsaneva-Atanasova, Krasimira; O'Neill, Stephen; Sitsapesan, Rebecca

    2012-01-01

    Changes in FKBP12.6 binding to cardiac ryanodine receptors (RyR2) are implicated in mediating disturbances in Ca(2+)-homeostasis in heart failure but there is controversy over the functional effects of FKBP12.6 on RyR2 channel gating. We have therefore investigated the effects of FKBP12.6 and another structurally similar molecule, FKBP12, which is far more abundant in heart, on the gating of single sheep RyR2 channels incorporated into planar phospholipid bilayers and on spontaneous waves of Ca(2+)-induced Ca(2+)-release in rat isolated permeabilised cardiac cells. We demonstrate that FKBP12 is a high affinity activator of RyR2, sensitising the channel to cytosolic Ca(2+), whereas FKBP12.6 has very low efficacy, but can antagonise the effects of FKBP12. Mathematical modelling of the data shows the importance of the relative concentrations of FKBP12 and FKBP12.6 in determining RyR2 activity. Consistent with the single-channel results, physiological concentrations of FKBP12 (3 µM) increased Ca(2+)-wave frequency and decreased the SR Ca(2+)-content in cardiac cells. FKBP12.6, itself, had no effect on wave frequency but antagonised the effects of FKBP12.We provide a biophysical analysis of the mechanisms by which FK-binding proteins can regulate RyR2 single-channel gating. Our data indicate that FKBP12, in addition to FKBP12.6, may be important in regulating RyR2 function in the heart. In heart failure, it is possible that an alteration in the dual regulation of RyR2 by FKBP12 and FKBP12.6 may occur. This could contribute towards a higher RyR2 open probability, 'leaky' RyR2 channels and Ca(2+)-dependent arrhythmias. PMID:22363773

  9. (CN{sub 3}H{sub 6}){sub 2} {center_dot} Zn(HPO{sub 3}){sub 2}: A Three-Dimensional Framework Zincophosphite Containing Polyhedral 12-Rings

    SciTech Connect

    HARRISON,WILLIAM T.A.; PHILLIPS,MARK L.F.; NENOFF,TINA M.

    2000-10-24

    The solution-mediated synthesis and single crystal structure of (CN{sub 3}H{sub 6}){sub 2} {center_dot} Zn(HPO{sub 3}){sub 2} are reported. This phase is built up from a three-dimensional framework of vertex-linked ZnO{sub 4} and HPO{sub 3} building units encapsulating the extra-framework guanidinium cations. The structure is stabilized by template-to-framework hydrogen bonding. The inorganic framework shows a surprising similarity to those of some known zinc phosphates. Crystal data: (CN{sub 3}H{sub 6}){sub 2} {center_dot} Zn(HPO{sub 3}){sub 2}, AI,= 345.50, orthorhombic, space group Fdd2 (No. 43), a = 15.2109 (6) {angstrom}, b = 11.7281 (5) {angstrom}, c = 14.1821 (6) {angstrom}, V = 2530.0 (4){angstrom}{sup 3}, Z = 8, T = 298 (2)K, R(F) = 0.020, wR(F) = 0.025.

  10. Isotope shifts of the 6d{sup 2} D{sub 3/2}-7 p{sup 2} P{sub 1/2} transition in trapped short-lived {sup 209-214}Ra{sup +}

    SciTech Connect

    Giri, G. S.; Versolato, O. O.; Berg, J. E. van den; Boell, O.; Dammalapati, U.; Hoek, D. J. van der; Jungmann, K.; Kruithof, W. L.; Mueller, S.; Nunez Portela, M.; Onderwater, C. J. G.; Santra, B.; Timmermans, R. G. E.; Wansbeek, L. W.; Willmann, L.; Wilschut, H. W.

    2011-08-15

    Laser spectroscopy of short-lived radium isotopes in a linear Paul trap has been performed. The isotope shifts of the 6d{sup 2} D{sub 3/2} -7 p{sup 2} P{sub 1/2} transition in {sup 209-214}Ra{sup +}, which are sensitive to the short-range part of the atomic wave functions, were measured. The results are essential experimental input for improving the precision of atomic structure calculations. This is indispensable for parity violation in Ra{sup +} aiming at the determination of the weak mixing angle.

  11. 12 CFR 932.6 - Operations risk capital requirement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Operations risk capital requirement. 932.6 Section 932.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.6 Operations risk capital...

  12. 12 CFR 931.6 - Transfer of capital stock.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Transfer of capital stock. 931.6 Section 931.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL STOCK § 931.6 Transfer of capital stock. A Bank in its capital...

  13. 12 CFR 925.6 - General eligibility requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false General eligibility requirements. 925.6 Section 925.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK MEMBERS AND HOUSING ASSOCIATES MEMBERS OF THE BANKS Eligibility Requirements § 925.6 General eligibility requirements....

  14. 12 CFR 980.6 - Finance Board consent.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Finance Board consent. 980.6 Section 980.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD NEW FEDERAL HOME LOAN BANK ACTIVITIES NEW BUSINESS ACTIVITIES § 980.6 Finance Board consent. The Finance Board may at any time provide consent for a Bank...

  15. 12 CFR 1209.6 - Temporary cease and desist orders.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Temporary cease and desist orders. 1209.6 Section 1209.6 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS RULES OF... Soundness Act § 1209.6 Temporary cease and desist orders. (a) Temporary cease and desist orders—(1)...

  16. 12 CFR 980.6 - Finance Board consent.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Finance Board consent. 980.6 Section 980.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD NEW FEDERAL HOME LOAN BANK ACTIVITIES NEW BUSINESS ACTIVITIES § 980.6 Finance Board consent. The Finance Board may at any time provide consent for a Bank...

  17. 12 CFR 1511.6 - Authority of Federal Reserve Banks.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Authority of Federal Reserve Banks. 1511.6 Section 1511.6 Banks and Banking DEPARTMENT OF THE TREASURY RESOLUTION FUNDING CORPORATION BOOK-ENTRY PROCEDURE § 1511.6 Authority of Federal Reserve Banks. (a) Each Federal Reserve Bank is hereby authorized...

  18. 12 CFR 1511.6 - Authority of Federal Reserve Banks.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Authority of Federal Reserve Banks. 1511.6 Section 1511.6 Banks and Banking DEPARTMENT OF THE TREASURY RESOLUTION FUNDING CORPORATION BOOK-ENTRY PROCEDURE § 1511.6 Authority of Federal Reserve Banks. (a) Each Federal Reserve Bank is hereby authorized...

  19. 12 CFR 1278.6 - Ratification by Bank members.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Ratification by Bank members. 1278.6 Section 1278.6 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS VOLUNTARY MERGERS OF FEDERAL HOME LOAN BANKS § 1278.6 Ratification by Bank members. (a) Requirements for member vote. No...

  20. 12 CFR 1278.6 - Ratification by Bank Members.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Ratification by Bank Members. 1278.6 Section 1278.6 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS VOLUNTARY MERGERS OF FEDERAL HOME LOAN BANKS § 1278.6 Ratification by Bank Members. (a) Requirements for member vote. No...

  1. 12 CFR 1278.6 - Ratification by Bank Members.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Ratification by Bank Members. 1278.6 Section 1278.6 Banks and Banking FEDERAL HOUSING FINANCE AGENCY FEDERAL HOME LOAN BANKS VOLUNTARY MERGERS OF FEDERAL HOME LOAN BANKS § 1278.6 Ratification by Bank Members. (a) Requirements for member vote. No...

  2. 12 CFR 931.6 - Transfer of capital stock.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Transfer of capital stock. 931.6 Section 931.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL STOCK § 931.6 Transfer of capital stock. A Bank in its capital...

  3. 12 CFR 932.6 - Operations risk capital requirement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Operations risk capital requirement. 932.6 Section 932.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.6 Operations risk capital...

  4. 12 CFR 330.6 - Single ownership accounts.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Single ownership accounts. 330.6 Section 330.6... DEPOSIT INSURANCE COVERAGE § 330.6 Single ownership accounts. (a) Individual accounts. Funds owned by a natural person and deposited in one or more deposit accounts in his or her own name shall be...

  5. 12 CFR 931.6 - Transfer of capital stock.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Transfer of capital stock. 931.6 Section 931.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL STOCK § 931.6 Transfer of capital stock. A Bank in its capital...

  6. 12 CFR 931.6 - Transfer of capital stock.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Transfer of capital stock. 931.6 Section 931.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL STOCK § 931.6 Transfer of capital stock. A Bank in its capital...

  7. 12 CFR 704.6 - Credit risk management.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Credit risk management. 704.6 Section 704.6... CREDIT UNIONS § 704.6 Credit risk management. (a) Policies. A corporate credit union must operate according to a credit risk management policy that is commensurate with the investment risks and...

  8. 12 CFR 932.6 - Operations risk capital requirement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Operations risk capital requirement. 932.6 Section 932.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL REQUIREMENTS § 932.6 Operations risk capital...

  9. 12 CFR 931.6 - Transfer of capital stock.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Transfer of capital stock. 931.6 Section 931.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK RISK MANAGEMENT AND CAPITAL STANDARDS FEDERAL HOME LOAN BANK CAPITAL STOCK § 931.6 Transfer of capital stock. A Bank in its capital...

  10. 12 CFR 704.6 - Credit risk management.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Credit risk management. 704.6 Section 704.6... CREDIT UNIONS § 704.6 Credit risk management. (a) Policies. A corporate credit union must operate according to a credit risk management policy that is commensurate with the investment risks and...

  11. 12 CFR 704.6 - Credit risk management.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 7 2013-01-01 2013-01-01 false Credit risk management. 704.6 Section 704.6... CREDIT UNIONS § 704.6 Credit risk management. (a) Policies. A corporate credit union must operate according to a credit risk management policy that is commensurate with the investment risks and...

  12. 12 CFR 6.5 - Capital restoration plans.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Capital restoration plans. 6.5 Section 6.5... Capital Categories § 6.5 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A bank shall file a written capital restoration plan with the OCC within 45 days of the date that the...

  13. 12 CFR 6.5 - Capital restoration plans.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Capital restoration plans. 6.5 Section 6.5... Capital Categories § 6.5 Capital restoration plans. (a) Schedule for filing plan—(1) In general. A bank shall file a written capital restoration plan with the OCC within 45 days of the date that the...

  14. 12 CFR 1010.6 - One hundred lot exemption.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false One hundred lot exemption. 1010.6 Section 1010.6 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION LAND REGISTRATION (REGULATION J) General Requirements § 1010.6 One hundred lot exemption. The sale of lots in a subdivision is exempt from...

  15. 12 CFR 1010.6 - One hundred lot exemption.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false One hundred lot exemption. 1010.6 Section 1010.6 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION LAND REGISTRATION (REGULATION J) General Requirements § 1010.6 One hundred lot exemption. The sale of lots in a subdivision is exempt from...

  16. 12 CFR 1010.6 - One hundred lot exemption.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false One hundred lot exemption. 1010.6 Section 1010.6 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION LAND REGISTRATION (REGULATION J) General Requirements § 1010.6 One hundred lot exemption. The sale of lots in a subdivision is exempt from...

  17. 12 CFR 108.6 - Initiation of hearing.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Initiation of hearing. 108.6 Section 108.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 108.6 Initiation of hearing. (a) Within 10 days of the...

  18. 12 CFR 108.6 - Initiation of hearing.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Initiation of hearing. 108.6 Section 108.6 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 108.6 Initiation of hearing. (a) Within 10 days of the...

  19. 12 CFR 508.6 - Initiation of hearing.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Initiation of hearing. 508.6 Section 508.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.6 Initiation of hearing. (a) Within 10 days of the...

  20. 12 CFR 508.6 - Initiation of hearing.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Initiation of hearing. 508.6 Section 508.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY REMOVALS, SUSPENSIONS, AND PROHIBITIONS WHERE A CRIME IS CHARGED OR PROVEN § 508.6 Initiation of hearing. (a) Within 10 days of the...

  1. 12 CFR 791.6 - Subject matter of a meeting.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... NATIONAL CREDIT UNION ADMINISTRATION RULES OF NCUA BOARD PROCEDURE; PROMULGATION OF NCUA RULES AND REGULATIONS; PUBLIC OBSERVATION OF NCUA BOARD MEETINGS Rules of NCUA Board Procedure § 791.6 Subject matter of... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Subject matter of a meeting. 791.6 Section...

  2. 12 CFR 1006.6 - Exemption from requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Exemption from requirements. 1006.6 Section 1006.6 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION FAIR DEBT COLLECTION PRACTICES ACT (REGULATION F) Procedures for State Application for Exemption From the Provisions of the Act § 1006.6 Exemption from requirements. If the...

  3. 12 CFR 310.6 - Special procedures: Medical records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Special procedures: Medical records. 310.6 Section 310.6 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION PROCEDURE AND RULES OF PRACTICE PRIVACY ACT REGULATIONS § 310.6 Special procedures: Medical records. Medical records shall be disclosed on request to the individuals to whom...

  4. 12 CFR 956.6 - Use of hedging instruments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Use of hedging instruments. 956.6 Section 956.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS FEDERAL HOME LOAN BANK INVESTMENTS § 956.6 Use of hedging instruments. (a) Applicability of...

  5. 12 CFR 956.6 - Use of hedging instruments.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Use of hedging instruments. 956.6 Section 956.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS FEDERAL HOME LOAN BANK INVESTMENTS § 956.6 Use of hedging instruments. (a) Applicability of...

  6. 12 CFR 1412.6 - Permissible indemnification payments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Permissible indemnification payments. 1412.6 Section 1412.6 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 1412.6 Permissible indemnification payments. (a) A System institution may make or...

  7. 12 CFR 1412.6 - Permissible indemnification payments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Permissible indemnification payments. 1412.6 Section 1412.6 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 1412.6 Permissible indemnification payments. (a) A System institution may make or...

  8. 12 CFR 1412.6 - Permissible indemnification payments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Permissible indemnification payments. 1412.6 Section 1412.6 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 1412.6 Permissible indemnification payments. (a) A System institution may make or...

  9. 12 CFR 1412.6 - Permissible indemnification payments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Permissible indemnification payments. 1412.6 Section 1412.6 Banks and Banking FARM CREDIT SYSTEM INSURANCE CORPORATION GOLDEN PARACHUTE AND INDEMNIFICATION PAYMENTS § 1412.6 Permissible indemnification payments. (a) A System institution may make or...

  10. 12 CFR 323.6 - Professional association membership; competency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Professional association membership; competency. 323.6 Section 323.6 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY APPRAISALS § 323.6 Professional association membership; competency. (a)...

  11. 12 CFR 564.6 - Professional association membership; competency.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Professional association membership; competency. 564.6 Section 564.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPRAISALS § 564.6 Professional association membership; competency. (a) Membership in appraisal...

  12. 12 CFR 564.6 - Professional association membership; competency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Professional association membership; competency. 564.6 Section 564.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY APPRAISALS § 564.6 Professional association membership; competency. (a) Membership in appraisal...

  13. 12 CFR 323.6 - Professional association membership; competency.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Professional association membership; competency. 323.6 Section 323.6 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY APPRAISALS § 323.6 Professional association membership; competency. (a)...

  14. 12 CFR 908.6 - Civil money penalties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Civil money penalties. 908.6 Section 908.6... Proceedings § 908.6 Civil money penalties. (a) Notice of assessment—(1) Grounds. The Finance Board may issue and serve a notice of assessment of a civil money penalty on any Bank or any executive officer...

  15. 12 CFR 908.6 - Civil money penalties.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Civil money penalties. 908.6 Section 908.6... Proceedings § 908.6 Civil money penalties. (a) Notice of assessment—(1) Grounds. The Finance Board may issue and serve a notice of assessment of a civil money penalty on any Bank or any executive officer...

  16. 12 CFR 944.6 - Bank community support programs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Bank community support programs. 944.6 Section 944.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK MISSION COMMUNITY SUPPORT REQUIREMENTS § 944.6 Bank community support programs. (a) Requirement. Consistent with the safe and...

  17. 12 CFR 1408.6 - Demand for payment.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Claims Collection Act of 1966, as amended, under the joint regulations (4 CFR parts 101-105), or under... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Demand for payment. 1408.6 Section 1408.6 Banks... Administrative Collection of Claims § 1408.6 Demand for payment. (a) A total of three progressively...

  18. 12 CFR 552.6-1 - Board of directors.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Board of directors. 552.6-1 Section 552.6-1...-INCORPORATION, ORGANIZATION, AND CONVERSION § 552.6-1 Board of directors. (a) General powers and duties. The business and affairs of the association shall be under the direction of its board of directors. The...

  19. 12 CFR 552.6-1 - Board of directors.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Board of directors. 552.6-1 Section 552.6-1...-INCORPORATION, ORGANIZATION, AND CONVERSION § 552.6-1 Board of directors. (a) General powers and duties. The business and affairs of the association shall be under the direction of its board of directors. The...

  20. Calcioferrite with composition (Ca3.94Sr0.06)Mg1.01(Fe2.93Al1.07)(PO4)6(OH)4·12H2O

    PubMed Central

    Lafuente, Barbara; Downs, Robert T.; Yang, Hexiong; Jenkins, Robert A.

    2014-01-01

    Calcioferrite, ideally Ca4MgFe3+ 4(PO4)6(OH)4·12H2O (tetra­calcium magnesium tetrairon(III) hexakis-phosphate tetra­hydroxide dodeca­hydrate), is a member of the calcioferrite group of hydrated calcium phosphate minerals with the general formula Ca4 AB 4(PO4)6(OH)4·12H2O, where A = Mg, Fe2+, Mn2+ and B = Al, Fe3+. Calcioferrite and the other three known members of the group, montgomeryite (A = Mg, B = Al), kingsmountite (A = Fe2+, B = Al), and zodacite (A = Mn2+, B = Fe3+), usually occur as very small crystals, making their structure refinements by conventional single-crystal X-ray diffraction challenging. This study presents the first structure determination of calcioferrite with composition (Ca3.94Sr0.06)Mg1.01(Fe2.93Al1.07)(PO4)6(OH)4·12H2O based on single-crystal X-ray diffraction data collected from a natural sample from the Moculta quarry in Angaston, Australia. Calcioferrite is isostructural with montgomeryite, the only member of the group with a reported structure. The calcioferrite structure is characterized by (Fe/Al)O6 octa­hedra (site symmetries 2 and -1) sharing corners (OH) to form chains running parallel to [101]. These chains are linked together by PO4 tetra­hedra (site symmetries 2 and 1), forming [(Fe/Al)3(PO4)3(OH)2] layers stacking along [010], which are connected by (Ca/Sr)2+ cations (site symmetry 2) and Mg2+ cations (site symmetry 2; half-occupation). Hydrogen-bonding inter­actions involving the water mol­ecules (one of which is equally disordered over two positions) and OH function are also present between these layers. The relatively weaker bonds between the layers account for the cleavage of the mineral parallel to (010). PMID:24764934

  1. Recovery 3 and 12 months after hysterectomy

    PubMed Central

    Theunissen, Maurice; Peters, Madelon L.; Schepers, Jan; Maas, Jacques W.M.; Tournois, Fleur; van Suijlekom, Hans A.; Gramke, Hans-Fritz; Marcus, Marco A.E.

    2016-01-01

    Abstract Chronic postsurgical pain (CPSP) is 1 important aspect of surgical recovery. To improve perioperative care and postoperative recovery knowledge on predictors of impaired recovery is essential. The aim of this study is to assess predictors and epidemiological data of CPSP, physical functioning (SF-36PF, 0–100), and global surgical recovery (global surgical recovery index, 0–100%) 3 and 12 months after hysterectomy for benign indication. A prospective multicenter cohort study was performed. Sociodemographic, somatic, and psychosocial data were assessed in the week before surgery, postoperatively up to day 4, and at 3- and 12-month follow-up. Generalized linear model (CPSP) and linear-mixed model analyses (SF-36PF and global surgical recovery index) were used. Baseline data of 468 patients were collected, 412 (88%) patients provided data for 3-month evaluation and 376 (80%) patients for 12-month evaluation. After 3 and 12 months, prevalence of CPSP (numeric rating scale ≥ 4, scale 0–10) was 10.2% and 9.0%, respectively, SF-36PF means (SD) were 83.5 (20.0) and 85.9 (20.2), global surgical recovery index 88.1% (15.6) and 93.3% (13.4). Neuropathic pain was reported by 20 (5.0%) patients at 3 months and 14 (3.9%) patients at 12 months. Preoperative pain, surgery-related worries, acute postsurgical pain on day 4, and surgery-related infection were significant predictors of CPSP. Baseline level, participating center, general psychological robustness, indication, acute postsurgical pain, and surgery-related infection were significant predictors of SF-36PF. Predictors of global surgical recovery were baseline expectations, surgery-related worries, American Society of Anesthesiologists classification, type of anesthesia, acute postsurgical pain, and surgery-related infection. Several predictors were identified for CPSP, physical functioning, and global surgical recovery. Some of the identified factors are modifiable and optimization of patients’ preoperative

  2. Line Positions and Intensities for the ν12 Band of 13C12CH_6

    NASA Astrophysics Data System (ADS)

    Devi, V. Malathy; Benner, D. Chris; Sung, Keeyoon; Crawford, Timothy J.; Mantz, Arlan; Smith, Mary Ann H.

    2014-06-01

    High-resolution, high signal-to-noise spectra of mono-substituted 13C-ethane (13C12CH_6) in the 12.2 μm region were recorded with a Bruker IFS 125HR Fourier transform spectrometer. The spectra were obtained for four sample pressures at three different temperatures between 130 and 208 K using a 99% 13C-enriched ethane sample contained in a 20.38-cm long coolable absorption cell. A multispectrum nonlinear least squares fitting technique was used to fit the same intervals in the four spectra simultaneously to determine line positions and intensities. Similar to our previous analyses of 12C_2H_6 spectra in this same region, constraints were applied to accurately fit each pair of doublet components arising from torsional Coriolis interaction of the excited ν12 = 1 state with the nearby torsional ν_6 = 3 state. Line intensities corresponding to each spectrum temperature (130 K, 178 K and 208 K) are reported for 1660 ν12 absorption lines for which the assignments are known, and integrated intensities are estimated as the summation of the measured values. The measured line positions and intensities (re-scaled to 296 K) are compared with values in recent editions of spectroscopic databases. K. Sung, A. W. Mantz, L. R. Brown, et al., J. Mol. Spectrosc., 162 (2010) 124-134. D. C. Benner, C. P. Rinsland, V. Malathy Devi, M. A. H. Smith and D. Atkins, JQSRT, 53 (1995) 705-721. V. Malathy Devi, C. P. Rinsland, D. Chris Benner, et al., JQSRT, 111 (2010) 1234-1251 V. Malathy Devi, D. Chris Benner, C. P. Rinsland, et al., JQSRT, 111 (2010) 2481-2504. Research described in this paper was performed at Connecticut College, the College of William and Mary, NASA Langley Research Center and the Jet Propulsion Laboratory, California Institute of Technology, under contracts and cooperative agreements with the National Aeronautics and Space Administration.

  3. 12 CFR 225.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regarding Delegation of Authority (12 CFR part 265) and the Board's Rules of Procedure (12 CFR part 262). (b... COMPANIES AND CHANGE IN BANK CONTROL (REGULATION Y) Regulations General Provisions § 225.3...

  4. Electronic Transitions of Jet-cooled SiC2, Si2Cn (n=1-3), Si3Cn (n = 1,2), and SiC6H4 between 250 and 710 nm

    NASA Astrophysics Data System (ADS)

    Steglich, M.; Maier, J. P.

    2015-03-01

    Electronic transitions of the title molecules were measured between 250 and 710 nm using a mass-resolved 1 + 1’ resonant two-photon ionization technique at a resolution of 0.1 nm. Calculations at the B3LYP/aug-cc-pVQZ level of theory support the analyses. Because of their spectral properties, SiC2, linear Si2C2, Si3C, and SiC6H4 are interesting target species for astronomical searches in the visible spectral region. Of special relevance is the Si-C2-Si chain, which features a prominent band at 516.4 nm of a strong transition (f = 0.25). This band and one from SiC6H4 at 445.3 nm were also investigated at higher resolution (0.002 nm).

  5. 6. VIEW OF INSCRIPTION 'APRIL 12, 1919, H. L. MALO,' ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW OF INSCRIPTION 'APRIL 12, 1919, H. L. MALO,' IN CONCRETE ABUTMENT ON THE SOUTH SIDE OF THE MAIN CANAL HEADGATE - Woodville Canal Company, West side of Snake River (River Mile 796), Woodville, Bingham County, ID

  6. 12. Level 6 gringing pans, pump above dorr thickener. View ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Level 6 gringing pans, pump above dorr thickener. View to west. - Kennecott Copper Corporation, Concentration Mill, On Copper River & Northwestern Railroad, Kennicott, Valdez-Cordova Census Area, AK

  7. 45 CFR 12.6 - Notice of available property.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... SURPLUS REAL PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.6 Notice of available property. Reasonable publicity... an opportunity to make an application therefor. However, publicity need not be given to...

  8. 45 CFR 12.6 - Notice of available property.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... SURPLUS REAL PROPERTY FOR PUBLIC HEALTH PURPOSES § 12.6 Notice of available property. Reasonable publicity... an opportunity to make an application therefor. However, publicity need not be given to...

  9. 6. General view from roof of Building 12 of interior ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. General view from roof of Building 12 of interior of complex. Building 13/14 stretches from left. View looking SE. - John & James Dobson Carpet Mill (West Parcel), 4041-4055 Ridge Avenue, Philadelphia, Philadelphia County, PA

  10. Safety for Your Child: 6 to 12 Months

    MedlinePlus

    ... Share Safety for Your Child: 6 to 12 Months Page Content Article Body ​ Did you know that ... may climb before walking, or walk with support months before you expect. Your child will grasp at ...

  11. 38 CFR 12.6 - Cases of living veterans.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... OF VETERAN'S PERSONAL FUNDS AND EFFECTS Disposition of Veteran's Personal Funds and Effects on Facility Upon Death, Or Discharge, Or Unauthorized Absence, and of Funds and Effects Found on Facility § 12.6 Cases of living veterans. (a) Except as provided in § 12.8, effects of veterans absent...

  12. 6 CFR 11.12 - Suspending or terminating collection activity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Suspending or terminating collection activity. 11.12 Section 11.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLAIMS... activity, or discharge indebtedness, in accordance with 31 CFR part 903. The Chief Financial Officer...

  13. 6 CFR 11.12 - Suspending or terminating collection activity.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Suspending or terminating collection activity. 11.12 Section 11.12 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY CLAIMS... activity, or discharge indebtedness, in accordance with 31 CFR part 903. The Chief Financial Officer...

  14. 12 CFR 270.3 - Governing principles.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Governing principles. 270.3 Section 270.3 Banks... Governing principles. As required by section 12A of the Federal Reserve Act, the time, character, and volume of all purchases and sales of obligations in the open market by Federal Reserve banks are...

  15. 12 CFR 270.3 - Governing principles.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Governing principles. 270.3 Section 270.3 Banks... Governing principles. As required by section 12A of the Federal Reserve Act, the time, character, and volume of all purchases and sales of obligations in the open market by Federal Reserve banks are...

  16. 1,2,3,4,6-penta-O-galloyl-β-D-glucose protects PC12 Cells from MPP(+)-mediated cell death by inducing heme oxygenase-1 in an ERK- and Akt-dependent manner.

    PubMed

    Chen, Hong; Li, Hongge; Cao, Fei; Zhen, Lan; Bai, Jing; Yuan, Shijin; Mei, Yuanwu

    2012-10-01

    This study examined the ability of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (β-PGG) to induce the expression of heme oxygenase-1 (HO-1) in the PC12 cells and its regulation in the PC12 cells. One week before treatment with the drug, nerve growth factor (NGF) was added to the cultures at a final concentration of 50 ng/mL to induce neuronal differentiation. After drug treatment, HO-1 gene transcription was analyzed by reverse transcription polymerase chain reaction (RT-PCR). Expression of HO-1 and NF-E2-related factor2 (Nrf2) and activation of extracellular signal-regulated kinase (ERK) and Akt were detected by Western blotting. The viability of the PC12 cells treated with different medicines was examined by MTT assay. The oxidative stress in the PC12 cells was evaluated qualitatively and quantitatively by DCFH-DA. The results showed that β-PGG up-regulated HO-1 expression and this increased expression provided neuroprotection against MPP(+)-induced oxidative injury. Moreover, β-PGG induced Nrf2 nuclear translocation, which was found to be upstream of β-PGG-induced HO-1 expression, and the activation of ERK and Akt, a pathway that is involved in β-PGG-induced Nrf2 nuclear translocation, HO-1 expression and neuroprotection. In conclusion, β-PGG up-regulates HO-1 expression by stimulating Nrf2 nuclear translocation in an ERK- and Akt-dependent manner, and HO-1 expression by β-PGG may provide the PC12 cells with an acquired antioxidant defense capacity to survive the oxidative stress.

  17. 12 CFR 975.6 - Pricing of services.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Pricing of services. 975.6 Section 975.6 Banks and Banking FEDERAL HOUSING FINANCE BOARD MISCELLANEOUS FEDERAL HOME LOAN BANK OPERATIONS AND...) General. Banks shall charge for services authorized in this part in a manner consistent with...

  18. 12 CFR 403.6 - Systematic review for declassification.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Systematic review for declassification. 403.6..., AND SAFEGUARDING OF NATIONAL SECURITY INFORMATION § 403.6 Systematic review for declassification... permanent retention will be subject to systematic declassification review by the Archivist in...

  19. 12 CFR 336.6 - Verfication of compliance.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Verfication of compliance. 336.6 Section 336.6 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY FDIC EMPLOYEES Minimum Standards of Fitness for Employment With the Federal Deposit...

  20. 12 CFR 336.6 - Verfication of compliance.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Verfication of compliance. 336.6 Section 336.6 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY FDIC EMPLOYEES Minimum Standards of Fitness for Employment With the Federal Deposit...

  1. 12 CFR 310.6 - Special procedures: Medical records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Special procedures: Medical records. 310.6... PRIVACY ACT REGULATIONS § 310.6 Special procedures: Medical records. Medical records shall be disclosed on... transmission of the medical information directly to the requesting individual could have an adverse effect...

  2. 12 CFR 310.6 - Special procedures: Medical records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Special procedures: Medical records. 310.6... PRIVACY ACT REGULATIONS § 310.6 Special procedures: Medical records. Medical records shall be disclosed on... transmission of the medical information directly to the requesting individual could have an adverse effect...

  3. 12 CFR 713.6 - What is the permissible deductible?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false What is the permissible deductible? 713.6... FIDELITY BOND AND INSURANCE COVERAGE FOR FEDERAL CREDIT UNIONS § 713.6 What is the permissible deductible? (a)(1) The maximum amount of allowable deductible is computed based on a federal credit union's...

  4. Solution combustion synthesis and enhanced electrochemical performance Li{sub 1.2}Ni{sub 0.2}Mn{sub 0.6}O{sub 2} nanoparticles by controlling NO{sub 3}{sup –}/CH{sub 3}COO{sup –} ratio of the precursors

    SciTech Connect

    Zhang, Qingtang; Mei, Juntao; Xie, Xiaolong; Wang, Xiaomei; Zhang, Junyan

    2015-10-15

    Highlights: • The size of Li{sub 1.2}Ni{sub 0.2}Mn{sub 0.6}O{sub 2} nanoparticles can be controlled by NO{sub 3}{sup −}/CH{sub 3}COO{sup −} ratio. • 35 nm Li{sub 1.2}Ni{sub 0.2}Mn{sub 0.6}O{sub 2} nanoparticles can be obtained with 3:1 NO{sub 3}{sup –}/CH{sub 3}COO{sup –} ratio. • 35 nm Li{sub 1.2}Ni{sub 0.2}Mn{sub 0.6}O{sub 2} nanoparticles shows excellent electrochemical performance. - Abstract: Lithium-rich layer oxide Li{sub 1.2}Ni{sub 0.2}Mn{sub 0.6}O{sub 2} nanoparticles were fabricated through solution combustion synthesis by controlling NO{sub 3}{sup –}/CH{sub 3}COO{sup –} ratio of the precursors. The relationships between the NO{sub 3}{sup –}/CH{sub 3}COO{sup –} ratio and structure as well as electrochemical performance of Li{sub 1.2}Ni{sub 0.2}Mn{sub 0.6}O{sub 2} nanoparticles are investigated. XRD reveals that Li{sub 1.2}Ni{sub 0.2}Mn{sub 0.6}O{sub 2} nanoparticles obtained with a suitable NO{sub 3}{sup –}/CH{sub 3}COO{sup –} ratio of 3:1 (LLO-3N1A) is composed of the smallest nanocrystallite of 18 nm. SEM reflects that the average primary particles of LLO-3N1A are the smallest with a size of 35 nm. Those unique characteristic guarantee the excellent electrochemical performance of LLO-3N1A. LLO-3N1A exhibits a specific capacity of 252.3 mA h g{sup −1} at 0.1 C. In addition, LLO-3N1A also shows best rate capability among the four prepared Li{sub 1.2}Ni{sub 0.2}Mn{sub 0.6}O{sub 2} samples.

  5. Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.

    PubMed

    Ruggeri, Roger B; Buckbinder, Leonard; Bagley, Scott W; Carpino, Philip A; Conn, Edward L; Dowling, Matthew S; Fernando, Dilinie P; Jiao, Wenhua; Kung, Daniel W; Orr, Suvi T M; Qi, Yingmei; Rocke, Benjamin N; Smith, Aaron; Warmus, Joseph S; Zhang, Yan; Bowles, Daniel; Widlicka, Daniel W; Eng, Heather; Ryder, Tim; Sharma, Raman; Wolford, Angela; Okerberg, Carlin; Walters, Karen; Maurer, Tristan S; Zhang, Yanwei; Bonin, Paul D; Spath, Samantha N; Xing, Gang; Hepworth, David; Ahn, Kay; Kalgutkar, Amit S

    2015-11-12

    Myeloperoxidase (MPO) is a heme peroxidase that catalyzes the production of hypochlorous acid. Clinical evidence suggests a causal role for MPO in various autoimmune and inflammatory disorders including vasculitis and cardiovascular and Parkinson's diseases, implying that MPO inhibitors may represent a therapeutic treatment option. Herein, we present the design, synthesis, and preclinical evaluation of N1-substituted-6-arylthiouracils as potent and selective inhibitors of MPO. Inhibition proceeded in a time-dependent manner by a covalent, irreversible mechanism, which was dependent upon MPO catalysis, consistent with mechanism-based inactivation. N1-Substituted-6-arylthiouracils exhibited low partition ratios and high selectivity for MPO over thyroid peroxidase and cytochrome P450 isoforms. N1-Substituted-6-arylthiouracils also demonstrated inhibition of MPO activity in lipopolysaccharide-stimulated human whole blood. Robust inhibition of plasma MPO activity was demonstrated with the lead compound 2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999, 8) upon oral administration to lipopolysaccharide-treated cynomolgus monkeys. On the basis of its pharmacological and pharmacokinetic profile, PF-06282999 has been advanced to first-in-human pharmacokinetic and safety studies. PMID:26509551

  6. New lithium copper borates with BO3 triangles: Li6CuB4O10, Li3CuB3O7, Li8Cu7B14O32, and Li2Cu9B12O28.

    PubMed

    Kuratieva, N V; Bànki, M; Tsirlin, A A; Eckert, J; Ehrenberg, H; Mikhailova, D

    2013-12-16

    Crystal structures of three new lithium copper borates, Li3CuB3O7, Li8Cu7B14O32, and Li2Cu9B12O28, and a new Li6CuB4O10 polymorph were solved by single-crystal X-ray diffraction. In all of the structures, the boron cations form BO3 triangles, which are connected with each other and with copper polyhedra only via corners in Li6CuB4O10 and Li3CuB3O7 and via both corners and edges in Li8Cu7B14O32 and Li2Cu9B12O28. The Li3CuB3O7 and Li8Cu7B14O32 compounds were synthesized as pure samples with only trace amounts of impurities; hence, their magnetic properties could be investigated and analyzed in terms of underlying magnetic couplings. Other compositions always represented multiphase mixtures. Li3CuB3O7 features infinite Cu,O chains formed by Cu2O6 units consisting of edge-shared CuO4 squares. Together with two apical oxygen atoms with long interatomic Cu-O distances of 2.7-2.8 Å, the Cu2O6 units form chains extended along the a axis. These pseudochains are responsible for strong anisotropic thermal expansion behavior. The temperature dependence of the magnetization between 4 and 380 K for Li3CuB3O7 could be fit well by a spin-dimer model. The magnetic susceptibility of Li8Cu7B14O32 showed a more complex temperature dependence, with two different Curie-Weiss regimes in the temperature range of 2-380 K. PMID:24266792

  7. 45 CFR 12.3 - General policies.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false General policies. 12.3 Section 12.3 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION DISPOSAL AND UTILIZATION OF SURPLUS REAL... because of race, color, sex, handicap, or national origin in the use of the property....

  8. 45 CFR 12.3 - General policies.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 45 Public Welfare 1 2012-10-01 2012-10-01 false General policies. 12.3 Section 12.3 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION DISPOSAL AND UTILIZATION OF SURPLUS REAL... because of race, color, sex, handicap, or national origin in the use of the property....

  9. 12 CFR 270.3 - Governing principles.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 4 2013-01-01 2013-01-01 false Governing principles. 270.3 Section 270.3 Banks... Governing principles. As required by section 12A of the Federal Reserve Act, the time, character, and volume of all purchases and sales of obligations in the open market by Federal Reserve banks are...

  10. 12 CFR 270.3 - Governing principles.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 4 2012-01-01 2012-01-01 false Governing principles. 270.3 Section 270.3 Banks... Governing principles. As required by section 12A of the Federal Reserve Act, the time, character, and volume of all purchases and sales of obligations in the open market by Federal Reserve banks are...

  11. 12 CFR 270.3 - Governing principles.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 4 2014-01-01 2014-01-01 false Governing principles. 270.3 Section 270.3 Banks... Governing principles. As required by section 12A of the Federal Reserve Act, the time, character, and volume of all purchases and sales of obligations in the open market by Federal Reserve banks are...

  12. 12 CFR 1770.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Definitions. 1770.3 Section 1770.3 Banks and... Charter Act and the Federal Home Loan Mortgage Corporation Act, which are codified at 12 U.S.C. 1716.... Compensation includes all direct and indirect payments of benefits, both cash and non-cash, granted to or...

  13. 18 CFR 12.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Definitions. 12.3 Section 12.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT WORKS...

  14. 18 CFR 12.3 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Definitions. 12.3 Section 12.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT WORKS...

  15. 18 CFR 12.3 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Definitions. 12.3 Section 12.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT WORKS...

  16. 18 CFR 12.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Definitions. 12.3 Section 12.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT WORKS...

  17. 18 CFR 12.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Definitions. 12.3 Section 12.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT SAFETY OF WATER POWER PROJECTS AND PROJECT WORKS...

  18. {(3aR,5S,6R,6aR)-5-[(R)-1,2-Di-hydroxy-eth-yl]-2,2-di-methyl-tetra-hydro-furo[2,3-d][1,3]dioxol-6-yl}methyl methane-sulfonate.

    PubMed

    Rjabovs, Vitālijs; Mishnev, Anatoly; Kiselovs, Glebs; Turks, Māris

    2014-05-01

    In the title compound, C11H20O8S, the furan-ose ring has a pseudorotation phase angle equal to 31.3° and assumes a (3) T 4 conformation, with deviations of 0.297 (4) and -0.152 (4) Å for the corresponding C atoms. The dioxolane ring adopts an envelope conformation. One of the O atoms is at the flap and deviates from the least-squares plane formed by the other four ring atoms by 0.405 (2) Å. The dihedral angle between the planar fragments of the rings is 63.53 (8)°. In the crystal, mol-ecules are associated into sheets perpendiculer to the b axis by means of O-H⋯O hydrogen bonds. A few weak C-H⋯O inter-actions are also observed.

  19. 2-(4-Methyl-pyridin-2-yl)-4',4',6',6'-tetra-kis-(pyrrolidin-1-yl)-1H,2H-spiro-[naphtho-[1,2-e][1,3,2]oxaza-phosphinine-3,2'-[1,3,5,2,4,6]tri-aza-triphosphinine].

    PubMed

    Işıklan, Muhammet; Sonkaya, Omer; Hökelek, Tuncer

    2013-06-01

    In the title spiro-phosphazene derivative, C33H46N9OP3, the phosphazene and six-membered N/O rings are in flattened chair and twisted-boat conformations, respectively. The naphthalene ring system and the pyridine ring are oriented at a dihedral angle of 41.82 (4)°. In the crystal, weak C-H⋯O hydrogen bonds link the mol-ecules related by translation along the a axis into chains. C-H⋯π inter-actions aggregate these chains into layers parallel to the ab plane. PMID:23795145

  20. Crystal structure of (E)-2-[(2-bromopyridin-3-yl)methyl-idene]-6-meth-oxy-3,4-di-hydro-naphthalen-1(2H)-one and 3-[(E)-(6-meth-oxy-1-oxo-1,2,3,4-tetra-hydro-naphthalen-2-ylidene)meth-yl]pyridin-2(1H)-one.

    PubMed

    Zingales, Sarah K; Moore, Morgan E; Goetz, Andrew D; Padgett, Clifford W

    2016-07-01

    The title compounds C17H14BrNO2, (I), and C17H15NO3, (II), were obtained from the reaction of 6-meth-oxy-3,4-di-hydro-2H-naphthalen-1-one and 2-bromo-nicotinaldehyde in ethanol. Compound (I) was the expected product and compound (II) was the oxidation product from air exposure. In the crystal structure of compound (I), there are no short contacts or hydrogen bonds. The structure does display π-π inter-actions between adjacent benzene rings and adjacent pyridyl rings. Compound (II) contains two independent mol-ecules, A and B, in the asymmetric unit; both are non-planar, the dihedral angles between the meth-oxy-benzene and 1H-pyridin-2-one mean planes being 35.07 (9)° in A and 35.28 (9)°in B. In each mol-ecule, the 1H-pyridin-2-one unit participates in inter-molecular N-H⋯O hydrogen bonding to another mol-ecule of the same type (A to A or B to B). The structure also displays π-π inter-actions between the pyridyl and the benzene rings of non-equivalent mol-ecules (viz., A to B and B to A). PMID:27555939

  1. Magnetic properties, microstructure and corrosion behavior of (Pr,nd)12.6Fe81.3B6.1-type sintered magnets doped with (Pr,nd)30Fe62Ga8

    NASA Astrophysics Data System (ADS)

    Ni, Junjie; Zhang, Zhenyu; Liu, Ying; Jia, Zhengfeng; Huang, Baoxu; Yin, Yibin

    2016-10-01

    NdFeB sintered magnets with (Pr,Nd)30Fe62Ga8 were prepared by a binary powder blending method and their magnetic properties, microstructure and corrosion behavior were investigated. Addition of 3 wt% (Pr,Nd)30Fe62Ga8 was found to be the most effective for improving (BH)max and iHc of the magnets. The increase in both magnetic parameters was related to the alteration in microstructure. However, in other samples the occurrence of micropore and the aggregation of intergranular phases harmed the magnetic properties. Such disadvantageous microstructure features also caused higher corrosion current density, thus decreasing the corrosion resistance of the sample with higher additive content. In addition, the Ga-containing intergranular phases that are more stable than the (Pr,Nd)-rich phase formed in the additive doped magnets, leading to better corrosion resistance of the 3 wt% additives doped sample in comparison with the contrastive sample.

  2. Structure and superconducting properties of ((Ln(1-x)Ln*(x) 1/2 (Ba(1-y)Sr(y) 1/3 Ce 1/6)8Cu6O(z)

    NASA Technical Reports Server (NTRS)

    Yamauchi, H.; Wada, T.; Ichinose, A.; Taegashi, Y.; Kaneko, T.; Ikegawa, S.; Tanaka, S.

    1991-01-01

    A variety of new oxide superconductors were prepared. The crystallographic structures of the oxides were all tetragonal and of the (Ln(+),Ce)4(Ln(+),Ba)4Cu6Oz (Ln(+) = Nd, Sm or Eu) type which had been previously discovered by Akimitsu et al. As the Sr content, y, increased when Ln = Ln(excited state) = Nd, the oxygen content, z, monotonically increased and the superconducting transition temperature, T sub c, varied exhibiting a maximum. When z was controlled directly by means of high oxygen pressure sintering techniques, T sub c was changed accordingly. T sub c's of samples with different combinations of Ln and Ln(excited state) and different values of x and y were found to depend on the magnitude of the bond valence sum for a Cu atom located in the bottom plane of the Cu-O5 pyramid. Transport and magnetization measurements were carried out to investigate the magnetic field dependence of superconducting properties and to determine the phenomenological parameters. The Hall coefficients were positive below room temperature and varied yielding a maximum with respect to temperature.

  3. Structure and superconducting properties of ((Ln(1-x)Ln*(x) 1/2 (Ba(1-y)Sr(y) 1/3 Ce 1/6) 8Cu6O(z)

    NASA Technical Reports Server (NTRS)

    Yamauchi, H.; Wada, T.; Ichinose, A.; Taegashi, Y.; Kaneko, T.; Ikegawa, S.; Tanaka, Shoji

    1990-01-01

    A variety of new oxide superconductors were prepared. The crystallographic structures of the oxides were all tetragonal and of the (Ln(+), Ce)4(Ln(+),Ba)4Cu6Oz (Ln(+) = Nd, Sm or Eu) type which had been previously discovered by Akimitsu et al. As the Sr content, y, increased when Ln = Ln(excited state) = Nd, the oxygen content, z, monotonically increased and the superconducting transition temperature, T(sub c), varied exhibiting a maximum. When z was controlled directly by means of high oxygen pressure sintering techniques, T(sub c) was changed accordingly. T(sub c's) of samples with different combinations of Ln and Ln(excited state) and different values of x and y were found to depend on the magnitude of the bond valence sum for a Cu atom located in the bottom plane of the Cu-O5 pyramid. Transport and magnetization measurements were carried out to investigate the magnetic field dependence of superconducting properties and to determine the phenomenological parameters. The Hall coefficients were positive below room temperature and varied yielding a maximum with respect to temperature.

  4. Structural investigations of a series of 1,6-aryl-7-hydroxy-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-ones with potential antinociceptive activity

    NASA Astrophysics Data System (ADS)

    Wysocki, Waldemar; Karczmarzyk, Zbigniew; Rządkowska, Marzena; Szacoń, Elżbieta; Matosiuk, Dariusz; Urbańczyk-Lipkowska, Zofia; Kalicki, Przemysław

    2015-08-01

    The structural investigations of a series of new bioactive imidazo[1,2-a]pyrimidines 1-6 were undertaken using IR, 1H and 13C NMR spectroscopic analysis, X-ray crystal structure determinations and theoretical calculations. The compounds 1-6 were obtained by condensation of the respective 1-aryl-4,5-dihydro-1H-imidazol-2-amine hydrobromide and diethyl phenylmalonate in presence of sodium methoxide in methanol and for these compounds the equilibrium between possible O10-enol/O11-keto (a), O11-enol/O10-keto (b) and O10,O11-diketo (c) tautomeric forms were investigated in the gaseous phase, solution and crystalline state. Spectroscopic studies 1H, 13C NMR and IR allowed for the identification of the compounds 1-6 but they did not indicate explicitly their tautomeric forms present in solution and in the solid state. The X-ray analysis showed that the molecules of all investigated compounds exist as the O10-enol/O11-keto (a) tautomeric form in the crystalline state. The hydroxyl and carbonyl groups characteristic for existing tautomeric form are involved in a strong intra- and/or intermolecular Osbnd H⋯O and Osbnd H⋯N hydrogen bonds. The theoretical calculations at DFT/B3LYP/6-311++G(d,p) level showed that two tautomeric forms (a) and (c) can coexist both in gas phase and the solution with the population of them being in the relation (a) > (or ≫) (c). The comparison of the experimentally recorded IR, 1H and 13C spectra with the corresponding spectra theoretically calculated for all possible tautomeric forms of 1-6 shows that the correlation of experimental and theoretical spectra can be used to a limited extent for the identification of tautomeric forms.

  5. LIMS Version 6 Level 3 Dataset

    NASA Technical Reports Server (NTRS)

    Remsberg, Ellis E.; Lingenfelser, Gretchen

    2010-01-01

    This report describes the Limb Infrared Monitor of the Stratosphere (LIMS) Version 6 (V6) Level 3 data products and the assumptions used for their generation. A sequential estimation algorithm was used to obtain daily, zonal Fourier coefficients of the several parameters of the LIMS dataset for 216 days of 1978-79. The coefficients are available at up to 28 pressure levels and at every two degrees of latitude from 64 S to 84 N and at the synoptic time of 12 UT. Example plots were prepared and archived from the data at 10 hPa of January 1, 1979, to illustrate the overall coherence of the features obtained with the LIMS-retrieved parameters.

  6. Spectral and quantum chemical studies on 1,3-bis(N(1)-4-amino-6-methoxypyrimidinebenzenesulfonamide-2,2,4,4-ethane-1,2-dithiol)-2,4-dichlorocyclodiphosph(V)azane and its erbium complex.

    PubMed

    Al-Mogren, Muneerah M; Alaghaz, Abdel-Nasser M A; El-Gogary, Tarek M

    2014-01-24

    Novel 1,3-bis(N(1)-4-amino-6-methoxypyrimidine-benzenesulfonamide-2,2,4,4-ethane-1,2-dithiol)-2,4-dichlorocyclodiphosph(V)azane (L), was prepared and their coordinating behavior towards the lanthanide ion Er(III) was studied. The structures of the isolated products are proposed based on elemental analyses, IR, UV-VIS., (1)H NMR, (13)C NMR, (31)P NMR, SEM, XRD, mass spectra, effective magnetic susceptibility measurements and thermogravimetric analysis (TGA). Computational studies have been carried out at the DFT-B3LYP/6-31G(d) level of theory on the structural and spectroscopic properties of L and its binuclear Er(III) complex. Different tautomers of the ligand were optimized at the ab initio DFT level. Keto-form structure is about 17.7 kcal/mol more stable than the enol form (taking zpe correction into account). Simulated IR frequencies were scaled and compared with that experimentally measured. TD-DFT method was used to compute the UV-VIS spectra which compared by the measured electronic spectra.

  7. Light induced elimination of mono- and polychlorinated phenols from aqueous solutions by PW{sub 12}O{sub 40}{sup 3{minus}}. The case of 2,4,6-trichlorophenol

    SciTech Connect

    Androulaki, E.; Hiskia, A.; Dimotikali, D.; Minero, C.; Calza, P.; Pelizzetti, E.; Papaconstantinou, E.

    2000-05-15

    Light induced catalytic decomposition of several moni-, di, and trichlorophenols and phenol in the presence of PW{sub 12}O{sub 40}{sup 3{minus}} in aqueous solutions (pH 1) leads to mineralization of substrates. The method is an example of Advanced Oxidation Processes (AOP) that cause mineralization of organic pollutants through the generation of very active, mainly OH, radicals. Generally, chlorination of phenolic ring enhances the decomposition, whereas the effect of chlorine substituents in the ortho position is less pronounced. However, the rates of decomposition of chlorinated phenols are very much the same. Dioxygen's main function seems to be the regeneration of the catalyst, with limited participation in the initial stages of the photoreactions. A detailed study of 2,4,6-trichlorophenol (2,3,6-TCP) photodecomposition showed that key reactions involved were hydroxylation, substitution of chlorine by OH radicals mainly in the ortho and para positions, and breaking of the aromatic ring. Ring-opened products detected were maleic, oxalic, acetic, and formic acids. Acetic acid has been so far a common intermediate in the photodecomposition of aromatic compounds with this method. The ultimate products were CO{sub 2}, H{sub 2}O, and Cl{sup {minus}}.

  8. 12 CFR 229.3 - Administrative enforcement.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Administrative enforcement. 229.3 Section 229.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) General § 229.3 Administrative enforcement....

  9. 12 CFR 3.21 - Minority interest.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Minority interest. 3.21 Section 3.21 Banks and... Capital § 3.21 Minority interest. (a) Applicability. For purposes of § 3.20, a national bank or Federal savings association is subject to the minority interest limitations in this section if: (1) A...

  10. 12 CFR 226.3 - Exempt transactions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Exempt transactions. 226.3 Section 226.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM TRUTH IN LENDING (REGULATION Z) General § 226.3 Exempt transactions. This regulation does not apply to...

  11. 12 CFR 229.3 - Administrative enforcement.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 3 2013-01-01 2013-01-01 false Administrative enforcement. 229.3 Section 229.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM (CONTINUED) AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) General § 229.3...

  12. 12 CFR 229.3 - Administrative enforcement.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 3 2014-01-01 2014-01-01 false Administrative enforcement. 229.3 Section 229.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM (CONTINUED) AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) General § 229.3...

  13. 12 CFR 229.3 - Administrative enforcement.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 3 2011-01-01 2011-01-01 false Administrative enforcement. 229.3 Section 229.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) General § 229.3 Administrative enforcement....

  14. 12 CFR 229.3 - Administrative enforcement.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 3 2012-01-01 2012-01-01 false Administrative enforcement. 229.3 Section 229.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM AVAILABILITY OF FUNDS AND COLLECTION OF CHECKS (REGULATION CC) General § 229.3 Administrative enforcement....

  15. 12 CFR 226.3 - Exempt transactions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Exempt transactions. 226.3 Section 226.3 Banks and Banking FEDERAL RESERVE SYSTEM (CONTINUED) BOARD OF GOVERNORS OF THE FEDERAL RESERVE SYSTEM TRUTH IN LENDING (REGULATION Z) General § 226.3 Exempt transactions. This regulation does not apply to...

  16. 12 CFR 16.6 - Sales of nonconvertible debt.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the bank's or its bank holding company's Forms 10-K, 10-Q (or 10-KSB, 10-QSB), and 8-K (17 CFR part... information specified in Commission Rule 12g3-2(b) (17 CFR 240.12g3-2(b)) and provides purchasers the information specified in Commission Rule 144A(d)(4)(i) (17 CFR 230.144A(d)(4)(i)). A federal branch or...

  17. 12 CFR 16.6 - Sales of nonconvertible debt.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the bank's or its bank holding company's Forms 10-K, 10-Q (or 10-KSB, 10-QSB), and 8-K (17 CFR part... information specified in Commission Rule 12g3-2(b) (17 CFR 240.12g3-2(b)) and provides purchasers the information specified in Commission Rule 144A(d)(4)(i) (17 CFR 230.144A(d)(4)(i)). A federal branch or...

  18. 12 CFR 16.6 - Sales of nonconvertible debt.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... bank holding company's Forms 10-K, 10-Q (or 10-KSB, 10-QSB), and 8-K (17 CFR part 249) filed under the... Commission Rule 12g3-2(b) (17 CFR 240.12g3-2(b)) and provides purchasers the information specified in Commission Rule 144A(d)(4)(i) (17 CFR 230.144A(d)(4)(i)). A federal branch or agency that provides the...

  19. 12 CFR 16.6 - Sales of nonconvertible debt.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... information specified in Commission Rule 12g3-2(b) (17 CFR 240.12g3-2(b)) and provides purchasers the information specified in Commission Rule 144A(d)(4)(i) (17 CFR 230.144A(d)(4)(i)). A federal branch or agency... subsidiary of a bank holding company that has securities registered under the Exchange Act; (2) The debt...

  20. A critical review of both the synthesis approach and the receptor profile of the 8-chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide and analogue derivatives.

    PubMed

    Lazzari, Paolo; Distinto, Rita; Manca, Ilaria; Baillie, Gemma; Murineddu, Gabriele; Pira, Marilena; Falzoi, Matteo; Sani, Monica; Morales, Paula; Ross, Ruth; Zanda, Matteo; Jagerovic, Nadine; Pinna, Gérard Aimè

    2016-10-01

    8-Chloro-1-(2',4'-dichlorophenyl)-N-piperidin-1-yl-1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole-3-carboxamide 9a was discovered as potent and selective CB1 antagonist by part of our group few years ago. In particular it was reported to have an affinity towards the CB1 cannabinoid receptor (CB1R), expressed as Ki, of 0.00035 nM. Nevertheless significantly divergent data were reported for the same compound from other laboratories. To unequivocally define the receptor profile of 9a, we have critically reviewed both its synthesis approach and binding data. Here we report that, in contrast to our previously reported data, 9a showed a Ki value for CB1R in the order of nanomolar rather than of fentomolar range. The new determined receptor profile of 9a was also ascertained for analogue derivatives 9b-i, as well as for 12. Moreover, the structural features of the synthesized compounds necessary for CB1R were investigated. Amongst the novel series, effects on CB1R intrinsic activity was highlighted due to the substituents at the position 3 of the pyrazole ring of the 1,4,5,6-tetrahydrobenzo[6,7]cyclohepta[1,2-c]pyrazole scaffold. Although the cannabinoid receptor profile of 9a was reviewed in this work, the relevance of this compound in CB1R antagonist based drug discovery is confirmed.

  1. 12 CFR 262.3 - Applications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... (12 CFR part 208) in the case of applications specified in § 262.3(b)(1)(i)(A), and for at least... General Counsel, acting pursuant to delegated authority (12 CFR 265.2(b)(7)), shall determine whether or... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at...

  2. 12 CFR 262.3 - Applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... (12 CFR part 208) in the case of applications specified in § 262.3(b)(1)(i)(A), and for at least... General Counsel, acting pursuant to delegated authority (12 CFR 265.2(b)(7)), shall determine whether or... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at...

  3. 12 CFR 262.3 - Applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... (12 CFR part 208) in the case of applications specified in § 262.3(b)(1)(i)(A), and for at least... General Counsel, acting pursuant to delegated authority (12 CFR 265.2(b)(7)), shall determine whether or... of CFR Sections Affected, which appears in the Finding Aids section of the printed volume and at...

  4. 1,2-Dibromo-3-chloropropane (DBCP)

    Integrated Risk Information System (IRIS)

    1,2 - Dibromo - 3 - chloropropane ( DBCP ) ; CASRN 96 - 12 - 8 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessm

  5. Synthesis of paucimannose N-glycans by Caenorhabditis elegans requires prior actions of UDP-N-acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2-N-acetylglucosaminyltransferase I, alpha3,6-mannosidase II and a specific membrane-bound beta-N-acetylglucosaminidase.

    PubMed Central

    Zhang, Wenli; Cao, Pinjiang; Chen, Shihao; Spence, Andrew M; Zhu, Shaoxian; Staudacher, Erika; Schachter, Harry

    2003-01-01

    We have previously reported three Caenorhabditis elegans genes ( gly-12, gly-13 and gly-14 ) encoding UDP- N -acetyl-D-glucosamine:alpha-3-D-mannoside beta1,2- N -acetylglucosaminyltransferase I (GnT I), an enzyme essential for hybrid and complex N-glycan synthesis. GLY-13 was shown to be the major GnT I in worms and to be the only GnT I cloned to date which can act on [Manalpha1,6(Manalpha1,3)Manalpha1,6](Manalpha1,3)Manbeta1, 4GlcNAcbeta1,4GlcNAc-R, but not on Manalpha1,6(Manalpha1,3)Manbeta1- O -R substrates. We now report the kinetic constants, bivalent-metal-ion requirements, and optimal pH, temperature and Mn(2+) concentration for this unusual enzyme. C. elegans glycoproteins are rich in oligomannose (Man(6-9)GlcNAc(2)) and 'paucimannose' Man(3-5)GlcNAc(2)(+/-Fuc) N-glycans, but contain only small amounts of complex and hybrid N-glycans. We show that the synthesis of paucimannose Man(3)GlcNAc(2) requires the prior actions of GnT I, alpha3,6-mannosidase II and a membrane-bound beta- N -acetylglucosaminidase similar to an enzyme previously reported in insects. The beta- N -acetylglucosaminidase removes terminal N -acetyl-D-glucosamine from the GlcNAcbeta1, 2Manalpha1,3Manbeta- arm of Manalpha1,6(GlcNAcbeta1,2Manalpha1,3) Manbeta1,4GlcNAcbeta1,4GlcNAc-R to produce paucimannose Man(3)GlcNAc(2) N-glycan. N -acetyl-D-glucosamine removal was inhibited by two N -acetylglucosaminidase inhibitors. Terminal GlcNAc was not released from [Manalpha1,6(Manalpha1,3)Manalpha 1,6] (GlcNAcbeta1,2Manalpha1,3)Manbeta1,4GlcNAcbeta1,4GlcNAc-R nor from the GlcNAcbeta1,2Manalpha1,6Manbeta- arm. These findings indicate that GLY-13 plays an important role in the synthesis of N-glycans by C. elegans and that therefore the worm should prove to be a suitable model for the study of the role of GnT I in nematode development. PMID:12603202

  6. Family Characteristics of 6- to 12-Year-Olds.

    ERIC Educational Resources Information Center

    Education Statistics Quarterly, 2000

    2000-01-01

    Contains 1972 to 1997 data on family characteristics such as parents' educational attainment and family income. The educational attainment of parents of children aged 6 to 12 increased substantially between 1972 and 1997, as did the employment rate of mothers. (SLD)

  7. 12 CFR 987.6 - Authority of Federal Reserve Banks.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CONSOLIDATED OBLIGATIONS § 987.6 Authority of Federal Reserve Banks. (a) Each Federal Reserve Bank is hereby... obligations in accounts established for such purposes; to make payments of principal, interest and redemption... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Authority of Federal Reserve Banks....

  8. Parallel Curriculum Units for Science, Grades 6-12

    ERIC Educational Resources Information Center

    Leppien, Jann H.; Purcell, Jeanne H.

    2011-01-01

    Based on the best-selling book "The Parallel Curriculum", this professional development resource gives multifaceted examples of rigorous learning opportunities for science students in Grades 6-12. The four sample units revolve around genetics, the convergence of science and society, the integration of language arts and biology, and the periodic…

  9. Home Economics/Health Grades 6-12. Program Evaluation.

    ERIC Educational Resources Information Center

    Des Moines Public Schools, IA. Teaching and Learning Div.

    Home economics programs are offered to students in grades 6-12 in the Des Moines INdependent Community School District (Iowa). Programs at the middle school level are exploratory, leading to occupational training in family and consumer science, child care, food service, and textile and fashion arts at the high school level. Health education…

  10. 12. VIEW OF PUMPS NO. 6, 8, AND 7 (L ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF PUMPS NO. 6, 8, AND 7 (L TO R) WITH THEIR CANVAS COVERS, LOOKING NORTHEAST. NOTE CONCRETE CONSTRUCTION. THE FOUR LIGHT WINDOWS AND THE STEEL EAM FOR THE 10-TON HAND OPERATED TRAVELING CRANE. - Wyoming Valley Flood Control System, Woodward Pumping Station, East of Toby Creek crossing by Erie-Lackawanna Railroad, Edwardsville, Luzerne County, PA

  11. 5-Amino-5'-bromo-6-(4-methyl-benzo-yl)-8-nitro-2,3-di-hydro-1H-spiro-[imidazo[1,2-a]pyridine-7,3'-indolin]-2'-one including an unknown solvate.

    PubMed

    Nagalakshmi, R A; Suresh, J; Sivakumar, S; Kumar, R Ranjith; Lakshman, P L Nilantha

    2014-07-01

    In the title compound, C22H18BrN5O4, the central six-membered ring, derived from 1,4-di-hydro-pyridine, adopts a distorted boat conformation with a puckering amplitude of 0.197 (3) Å, the imidazole ring adopts a twisted conformation with a puckering amplitude of 0.113 (3) Å, and the oxindole moiety is planar with an r.m.s. deviation of 0.0125 Å. Two intra-molecular N-H⋯O hydrogen bonds are formed, each closing an S(6) loop. In the crystal, strong N-H⋯O hydrogen bonds lead to the formation of zigzag chains along the c axis. These are consolidated in the three-dimensional crystal packing by weak N-H⋯O hydrogen bonding, as well as by C-H⋯O, C-H⋯Br and C-H⋯π inter-actions. A small region of electron density well removed from the main mol-ecule was removed with the SQUEEZE procedure in PLATON [Spek (2009 ▶). Acta Cryst. D65, 148-155] following unsuccessful attempts to model it as a plausible solvent mol-ecule. The unit-cell characteristics do not take into account this feature of the structure. PMID:25161594

  12. The effects of azole-based heme oxygenase inhibitors on rat cytochromes P450 2E1 and 3A1/2 and human cytochromes P450 3A4 and 2D6.

    PubMed

    Hum, Maaike; McLaughlin, Brian E; Roman, Gheorghe; Vlahakis, Jason Z; Szarek, Walter A; Nakatsu, Kanji

    2010-09-01

    Heme oxygenases (HOs) catalyze the degradation of heme to biliverdin, carbon monoxide (CO), and free iron. The two major isoforms, HO-1 (inducible) and HO-2 (constitutive), are involved in a variety of physiological functions, including inflammation, apoptosis, neuromodulation, and vascular regulation. Major tools used in exploring these actions have been metalloporphyrin analogs of heme that inhibit the HOs. However, these tools are limited by their lack of selectivity; they affect other heme-dependent enzymes, such as cytochromes P450 (P450s), soluble guanylyl cyclase (sGC), and nitric-oxide synthase (NOS). Our laboratory has successfully synthesized a number of nonporphyrin azole-based HO inhibitors (QC-xx) that had little or no effect on sGC and NOS activity. However, their effects on various P450 isoforms have yet to be fully elucidated. To determine the effects of the QC-xx inhibitors on P450 enzyme activity, microsomal preparations of two rat P450 isoforms (2E1 and 3A1/3A2) and two human P450 supersome isoforms (3A4 and 2D6) were incubated with varying concentrations of HO inhibitor, and the activity was determined by spectrophotometric or fluorometric analysis. Results indicated that some QC compounds demonstrated little to no inhibition of the P450s, whereas others did inhibit these P450 isoforms. Four structural regions of QC-xx were analyzed, leading to the identification of structures that confer a decreased effect on both rat and human P450 isoforms studied while maintaining an inhibitory effect on the HOs.

  13. 12 CFR 13.3 - Business conduct.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Business conduct. 13.3 Section 13.3 Banks and....3 Business conduct. A bank that is a government securities broker or dealer shall observe high standards of commercial honor and just and equitable principles of trade in the conduct of its business as...

  14. 12 CFR 368.3 - Business conduct.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Business conduct. 368.3 Section 368.3 Banks and... SECURITIES SALES PRACTICES § 368.3 Business conduct. A bank that is a government securities broker or dealer... conduct of its business as a government securities broker or dealer....

  15. 12 CFR 583.3 - Bank.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Bank. 583.3 Section 583.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY DEFINITIONS FOR REGULATIONS AFFECTING SAVINGS AND LOAN HOLDING COMPANIES § 583.3 Bank. The term bank means any national bank, state bank,...

  16. 12 CFR 917.3 - Risk management.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Risk management. 917.3 Section 917.3 Banks and... RESPONSIBILITIES OF BANK BOARDS OF DIRECTORS AND SENIOR MANAGEMENT § 917.3 Risk management. (a) Risk management... all times a risk management policy that addresses the Bank's exposure to credit risk, market...

  17. 12 CFR 3.10 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Applicability. 3.10 Section 3.10 Banks and... DIRECTIVES Establishment of Minimum Capital Ratios for an Individual Bank § 3.10 Applicability. The OCC may require higher minimum capital ratios for an individual bank in view of its circumstances. For...

  18. 12 CFR 1203.3 - Eligible parties.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Eligible parties. 1203.3 Section 1203.3 Banks... General Provisions § 1203.3 Eligible parties. (a) To be eligible for an award of fees and other expenses.... The applicant must also be a party to the adversary adjudication for which it seeks an award. (b)...

  19. 12 CFR 912.3 - Open meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Open meetings. 912.3 Section 912.3 Banks and... INFORMATION REGARDING MEETINGS OF THE BOARD OF DIRECTORS OF THE FEDERAL HOUSING FINANCE BOARD § 912.3 Open... be open to public observation. (b) Unless otherwise specified in the public notice, open meetings...

  20. 12 CFR 977.3 - Trustee powers.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Trustee powers. 977.3 Section 977.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD MISCELLANEOUS FEDERAL HOME LOAN BANK OPERATIONS AND AUTHORITIES MISCELLANEOUS BANK AUTHORITIES § 977.3 Trustee powers. A Bank may act, and make reasonable charges for doing...

  1. 12 CFR 326.3 - Security program.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Security program. 326.3 Section 326.3 Banks and... SECURITY DEVICES AND PROCEDURES AND BANK SECRECY ACT 1 COMPLIANCE Minimum Security Procedures § 326.3 Security program. (a) Contents of security program. The security program shall: (1) Establish...

  2. 12 CFR 326.3 - Security program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Security program. 326.3 Section 326.3 Banks and... SECURITY DEVICES AND PROCEDURES AND BANK SECRECY ACT 1 COMPLIANCE Minimum Security Procedures § 326.3 Security program. (a) Contents of security program. The security program shall: (1) Establish...

  3. 12 CFR 326.3 - Security program.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false Security program. 326.3 Section 326.3 Banks and... SECURITY DEVICES AND PROCEDURES AND BANK SECRECY ACT 1 COMPLIANCE Minimum Security Procedures § 326.3 Security program. (a) Contents of security program. The security program shall: (1) Establish...

  4. 12 CFR 568.3 - Security program.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Security program. 568.3 Section 568.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SECURITY PROCEDURES § 568.3 Security program. (a) Contents of security program. The security program shall: (1) Establish procedures...

  5. 12 CFR 391.3 - Security program.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Security program. 391.3 Section 391.3 Banks and... OF THRIFT SUPERVISION REGULATIONS Security Procedures § 391.3 Security program. (a) Contents of security program. The security program shall: (1) Establish procedures for opening and closing for...

  6. 12 CFR 391.3 - Security program.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Security program. 391.3 Section 391.3 Banks and... OF THRIFT SUPERVISION REGULATIONS Security Procedures § 391.3 Security program. (a) Contents of security program. The security program shall: (1) Establish procedures for opening and closing for...

  7. 12 CFR 391.3 - Security program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false Security program. 391.3 Section 391.3 Banks and... OF THRIFT SUPERVISION REGULATIONS Security Procedures § 391.3 Security program. (a) Contents of security program. The security program shall: (1) Establish procedures for opening and closing for...

  8. 12 CFR 168.3 - Security program.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Security program. 168.3 Section 168.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY SECURITY PROCEDURES § 168.3 Security program. (a) Contents of security program. The security program shall: (1) Establish procedures...

  9. 12 CFR 326.3 - Security program.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Security program. 326.3 Section 326.3 Banks and... SECURITY DEVICES AND PROCEDURES AND BANK SECRECY ACT 1 COMPLIANCE Minimum Security Procedures § 326.3 Security program. (a) Contents of security program. The security program shall: (1) Establish...

  10. 12 CFR 311.3 - Meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Meetings. 311.3 Section 311.3 Banks and Banking... OF MEETINGS OF THE CORPORATION'S BOARD OF DIRECTORS § 311.3 Meetings. (a) Open meetings. Except as provided in paragraph (b) of this section, every portion of every meeting of the Corporation's Board...

  11. 12 CFR 13.3 - Business conduct.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 1 2011-01-01 2011-01-01 false Business conduct. 13.3 Section 13.3 Banks and....3 Business conduct. A bank that is a government securities broker or dealer shall observe high standards of commercial honor and just and equitable principles of trade in the conduct of its business as...

  12. 12 CFR 13.3 - Business conduct.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Business conduct. 13.3 Section 13.3 Banks and....3 Business conduct. A bank that is a government securities broker or dealer shall observe high standards of commercial honor and just and equitable principles of trade in the conduct of its business as...

  13. 12 CFR 13.3 - Business conduct.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Business conduct. 13.3 Section 13.3 Banks and....3 Business conduct. A bank that is a government securities broker or dealer shall observe high standards of commercial honor and just and equitable principles of trade in the conduct of its business as...

  14. 12 CFR 368.3 - Business conduct.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Business conduct. 368.3 Section 368.3 Banks and... SECURITIES SALES PRACTICES § 368.3 Business conduct. A bank that is a government securities broker or dealer... conduct of its business as a government securities broker or dealer....

  15. 12 CFR 13.3 - Business conduct.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Business conduct. 13.3 Section 13.3 Banks and....3 Business conduct. A bank that is a government securities broker or dealer shall observe high standards of commercial honor and just and equitable principles of trade in the conduct of its business as...

  16. 12 CFR 917.3 - Risk management.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Risk management. 917.3 Section 917.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD GOVERNANCE AND MANAGEMENT OF THE FEDERAL HOME LOAN BANKS POWERS AND RESPONSIBILITIES OF BANK BOARDS OF DIRECTORS AND SENIOR MANAGEMENT § 917.3 Risk management. (a) Risk...

  17. 12 CFR 917.3 - Risk management.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Risk management. 917.3 Section 917.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD GOVERNANCE AND MANAGEMENT OF THE FEDERAL HOME LOAN BANKS POWERS AND RESPONSIBILITIES OF BANK BOARDS OF DIRECTORS AND SENIOR MANAGEMENT § 917.3 Risk management. (a) Risk...

  18. 12 CFR 35.3 - CRA communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false CRA communications. 35.3 Section 35.3 Banks and... AGREEMENTS § 35.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the...) Discussions or contacts that are not CRA communications—(1) Timing of contacts with a Federal banking...

  19. 12 CFR 23.3 - Lease requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Lease requirements. 23.3 Section 23.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY LEASING General Provisions § 23.3 Lease... connection with leasing that property, and may engage in activities incidental thereto, if the...

  20. 12 CFR 1207.3 - Limitations.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 9 2013-01-01 2013-01-01 false Limitations. 1207.3 Section 1207.3 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS MINORITY AND WOMEN INCLUSION General § 1207.3 Limitations. (a) Except as expressly provided herein for enforcement by FHFA, the regulations...

  1. 12 CFR 1207.3 - Limitations.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 9 2012-01-01 2012-01-01 false Limitations. 1207.3 Section 1207.3 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS MINORITY AND WOMEN INCLUSION General § 1207.3 Limitations. (a) Except as expressly provided herein for enforcement by FHFA, the regulations...

  2. 12 CFR 1207.3 - Limitations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Limitations. 1207.3 Section 1207.3 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS MINORITY AND WOMEN INCLUSION General § 1207.3 Limitations. (a) Except as expressly provided herein for enforcement by FHFA, the regulations...

  3. 12 CFR 48.3 - Prohibited transactions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Prohibited transactions. 48.3 Section 48.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RETAIL FOREIGN EXCHANGE TRANSACTIONS § 48.3 Prohibited transactions. (a) Fraudulent conduct prohibited. No national bank or its...

  4. 12 CFR 48.3 - Prohibited transactions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Prohibited transactions. 48.3 Section 48.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RETAIL FOREIGN EXCHANGE TRANSACTIONS § 48.3 Prohibited transactions. (a) Fraudulent conduct prohibited. No national bank or its...

  5. 12 CFR 48.3 - Prohibited transactions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Prohibited transactions. 48.3 Section 48.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY RETAIL FOREIGN EXCHANGE TRANSACTIONS § 48.3 Prohibited transactions. (a) Fraudulent conduct prohibited. No national bank or its...

  6. 12 CFR 917.3 - Risk management.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Risk management. 917.3 Section 917.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD GOVERNANCE AND MANAGEMENT OF THE FEDERAL HOME LOAN BANKS POWERS AND RESPONSIBILITIES OF BANK BOARDS OF DIRECTORS AND SENIOR MANAGEMENT § 917.3 Risk management. (a) Risk...

  7. 12 CFR 563f.3 - Prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Prohibitions. 563f.3 Section 563f.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS § 563f.3 Prohibitions. (a) Community. A management official of a depository organization may not serve at the same...

  8. 12 CFR 348.3 - Prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Prohibitions. 348.3 Section 348.3 Banks and Banking FEDERAL DEPOSIT INSURANCE CORPORATION REGULATIONS AND STATEMENTS OF GENERAL POLICY MANAGEMENT OFFICIAL INTERLOCKS § 348.3 Prohibitions. (a) Community. A management official of a depository...

  9. 12 CFR 26.3 - Prohibitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 1 2010-01-01 2010-01-01 false Prohibitions. 26.3 Section 26.3 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY MANAGEMENT OFFICIAL INTERLOCKS § 26.3 Prohibitions. (a) Community. A management official of a depository organization may not serve at the same...

  10. 12 CFR 917.3 - Risk management.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Risk management. 917.3 Section 917.3 Banks and... RESPONSIBILITIES OF BANK BOARDS OF DIRECTORS AND SENIOR MANAGEMENT § 917.3 Risk management. (a) Risk management... all times a risk management policy that addresses the Bank's exposure to credit risk, market...

  11. 12 CFR 1233.3 - Reporting.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 10 2014-01-01 2014-01-01 false Reporting. 1233.3 Section 1233.3 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ENTITY REGULATIONS REPORTING OF FRAUDULENT FINANCIAL INSTRUMENTS § 1233.3 Reporting. (a) Timeframe for reporting. (1) A regulated entity shall submit to the Director a timely written report upon discovery by...

  12. 12 CFR 1010.3 - General applicability.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false General applicability. 1010.3 Section 1010.3 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION LAND REGISTRATION (REGULATION J) General Requirements § 1010.3 General applicability. Except in the case of an exempt transaction, a developer may...

  13. 12 CFR 1010.3 - General applicability.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false General applicability. 1010.3 Section 1010.3 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION LAND REGISTRATION (REGULATION J) General Requirements § 1010.3 General applicability. Except in the case of an exempt transaction, a developer may...

  14. 12 CFR 1010.3 - General applicability.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false General applicability. 1010.3 Section 1010.3 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION LAND REGISTRATION (REGULATION J) General Requirements § 1010.3 General applicability. Except in the case of an exempt transaction, a developer may...

  15. 12 CFR 1006.3 - Supporting documents.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 8 2014-01-01 2014-01-01 false Supporting documents. 1006.3 Section 1006.3 Banks and Banking BUREAU OF CONSUMER FINANCIAL PROTECTION FAIR DEBT COLLECTION PRACTICES ACT (REGULATION F) Procedures for State Application for Exemption From the Provisions of the Act § 1006.3 Supporting documents. The application shall be...

  16. 12 CFR 583.3 - Bank.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Bank. 583.3 Section 583.3 Banks and Banking... AND LOAN HOLDING COMPANIES § 583.3 Bank. The term bank means any national bank, state bank, state-chartered savings bank, cooperative bank, or industrial bank, the deposits of which are insured by...

  17. 12 CFR 952.3 - Purpose.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Purpose. 952.3 Section 952.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD FEDERAL HOME LOAN BANK ASSETS AND OFF-BALANCE SHEET ITEMS COMMUNITY INVESTMENT CASH ADVANCE PROGRAMS § 952.3 Purpose. The purpose of this part is to identify targeted...

  18. 12 CFR 1207.3 - Limitations.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Limitations. 1207.3 Section 1207.3 Banks and Banking FEDERAL HOUSING FINANCE AGENCY ORGANIZATION AND OPERATIONS MINORITY AND WOMEN INCLUSION (Eff. Jan. 27, 2011) General § 1207.3 Limitations. (a) Except as expressly provided herein for enforcement...

  19. 12 CFR 977.3 - Trustee powers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 8 2013-01-01 2013-01-01 false Trustee powers. 977.3 Section 977.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD MISCELLANEOUS FEDERAL HOME LOAN BANK OPERATIONS AND AUTHORITIES MISCELLANEOUS BANK AUTHORITIES § 977.3 Trustee powers. A Bank may act, and make reasonable charges for doing...

  20. 12 CFR 977.3 - Trustee powers.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 7 2011-01-01 2011-01-01 false Trustee powers. 977.3 Section 977.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD MISCELLANEOUS FEDERAL HOME LOAN BANK OPERATIONS AND AUTHORITIES MISCELLANEOUS BANK AUTHORITIES § 977.3 Trustee powers. A Bank may act, and make reasonable charges for doing...

  1. 12 CFR 977.3 - Trustee powers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 8 2012-01-01 2012-01-01 false Trustee powers. 977.3 Section 977.3 Banks and Banking FEDERAL HOUSING FINANCE BOARD MISCELLANEOUS FEDERAL HOME LOAN BANK OPERATIONS AND AUTHORITIES MISCELLANEOUS BANK AUTHORITIES § 977.3 Trustee powers. A Bank may act, and make reasonable charges for doing...

  2. 12 CFR 207.3 - CRA communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 2 2013-01-01 2013-01-01 false CRA communications. 207.3 Section 207.3 Banks... REPORTING OF CRA-RELATED AGREEMENTS (REGULATION G) § 207.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or...

  3. 12 CFR 207.3 - CRA communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 2 2011-01-01 2011-01-01 false CRA communications. 207.3 Section 207.3 Banks... REPORTING OF CRA-RELATED AGREEMENTS (REGULATION G) § 207.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or...

  4. 12 CFR 346.3 - CRA communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false CRA communications. 346.3 Section 346.3 Banks... DISCLOSURE AND REPORTING OF CRA-RELATED AGREEMENTS § 346.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or...

  5. 12 CFR 346.3 - CRA communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false CRA communications. 346.3 Section 346.3 Banks... DISCLOSURE AND REPORTING OF CRA-RELATED AGREEMENTS § 346.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or...

  6. 12 CFR 207.3 - CRA communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 2 2010-01-01 2010-01-01 false CRA communications. 207.3 Section 207.3 Banks... REPORTING OF CRA-RELATED AGREEMENTS (REGULATION G) § 207.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or...

  7. 12 CFR 133.3 - CRA communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false CRA communications. 133.3 Section 133.3 Banks...-RELATED AGREEMENTS § 133.3 CRA communications. (a) Definition of CRA communication. A CRA communication is... any CRA affiliate. (b) Discussions or contacts that are not CRA communications—(1) Timing of...

  8. 12 CFR 533.3 - CRA communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false CRA communications. 533.3 Section 533.3 Banks...-RELATED AGREEMENTS § 533.3 CRA communications. (a) Definition of CRA communication. A CRA communication is... any CRA affiliate. (b) Discussions or contacts that are not CRA communications—(1) Timing of...

  9. 12 CFR 35.3 - CRA communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false CRA communications. 35.3 Section 35.3 Banks and... AGREEMENTS § 35.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the...) Discussions or contacts that are not CRA communications—(1) Timing of contacts with a Federal banking...

  10. 12 CFR 346.3 - CRA communications.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 4 2011-01-01 2011-01-01 false CRA communications. 346.3 Section 346.3 Banks... DISCLOSURE AND REPORTING OF CRA-RELATED AGREEMENTS § 346.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or...

  11. 12 CFR 207.3 - CRA communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 2 2012-01-01 2012-01-01 false CRA communications. 207.3 Section 207.3 Banks... REPORTING OF CRA-RELATED AGREEMENTS (REGULATION G) § 207.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or...

  12. 12 CFR 133.3 - CRA communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false CRA communications. 133.3 Section 133.3 Banks...-RELATED AGREEMENTS § 133.3 CRA communications. (a) Definition of CRA communication. A CRA communication is... any CRA affiliate. (b) Discussions or contacts that are not CRA communications—(1) Timing of...

  13. 12 CFR 35.3 - CRA communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false CRA communications. 35.3 Section 35.3 Banks and... AGREEMENTS § 35.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the...) Discussions or contacts that are not CRA communications—(1) Timing of contacts with a Federal banking...

  14. 12 CFR 346.3 - CRA communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 5 2014-01-01 2014-01-01 false CRA communications. 346.3 Section 346.3 Banks... DISCLOSURE AND REPORTING OF CRA-RELATED AGREEMENTS § 346.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or...

  15. 12 CFR 207.3 - CRA communications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 2 2014-01-01 2014-01-01 false CRA communications. 207.3 Section 207.3 Banks... REPORTING OF CRA-RELATED AGREEMENTS (REGULATION G) § 207.3 CRA communications. (a) Definition of CRA communication. A CRA communication is any of the following— (1) Any written or oral comment or...

  16. 12 CFR 703.3 - Investment policies.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 7 2014-01-01 2014-01-01 false Investment policies. 703.3 Section 703.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INVESTMENT AND DEPOSIT ACTIVITIES § 703.3 Investment policies. A Federal credit union's board of directors must...

  17. 12 CFR 703.3 - Investment policies.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 7 2012-01-01 2012-01-01 false Investment policies. 703.3 Section 703.3 Banks and Banking NATIONAL CREDIT UNION ADMINISTRATION REGULATIONS AFFECTING CREDIT UNIONS INVESTMENT AND DEPOSIT ACTIVITIES § 703.3 Investment policies. A Federal credit union's board of directors must...

  18. 12 CFR 590.3 - Operation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 12 Banks and Banking 5 2011-01-01 2011-01-01 false Operation. 590.3 Section 590.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY PREEMPTION OF STATE USURY LAWS § 590.3 Operation. (a) The provisions of the constitution or law of any state expressly limiting the rate or...

  19. Synthesis and structural characterization of Al{sub 7}C{sub 3}N{sub 3}-homeotypic aluminum silicon oxycarbonitride, (Al{sub 7-x}Si{sub x})(O{sub y}C{sub z}N{sub 6-y-z}) (x{approx}1.2, y{approx}1.0 and z{approx}3.5)

    SciTech Connect

    Urushihara, Daisuke; Kaga, Motoaki; Asaka, Toru; Nakano, Hiromi; Fukuda, Koichiro

    2011-08-15

    A new aluminum silicon oxycarbonitride, (Al{sub 5.8}Si{sub 1.2})(O{sub 1.0}C{sub 3.5}N{sub 1.5}), has been synthesized and characterized by X-ray powder diffraction (XRPD), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX) and electron energy loss spectroscopy (EELS). The title compound is hexagonal with space group P6{sub 3}/mmc and unit-cell dimensions a=0.322508(4) nm, c=3.17193(4) nm and V=0.285717(6) nm{sup 3}. The atom ratios of Al:Si and those of O:C:N were, respectively, determined by EDX and EELS. The initial structural model was successfully derived from the XRPD data by the direct methods and further refined by the Rietveld method. The crystal is most probably composed of four types of domains with nearly the same fraction, each of which is isotypic to Al{sub 7}C{sub 3}N{sub 3} with space group P6{sub 3}mc. The existence of another new oxycarbonitride (Al{sub 6.6}Si{sub 1.4})(O{sub 0.7}C{sub 4.3}N{sub 2.0}), which must be homeotypic to Al{sub 8}C{sub 3}N{sub 4}, has been also demonstrated by XRPD and TEM. - Graphical abstract: A new oxycarbonitride discovered in the Al-Si-O-C-N system, (Al{sub 7-x}Si{sub x})(O{sub y}C{sub z}N{sub 6-y-z}) (x{approx}1.2, y{approx}1.0 and z{approx}3.5). The crystal is composed of four types of domains (I, II, III and IV), and hence the structure is represented by a split-atom model. Individual crystal structures can be regarded as layered structures, which consist of A-type [(Al, Si){sub 4}(O, C, N){sub 4}] unit layers and B-type [(Al, Si)(O, C, N){sub 2}] single layers. Highlights: > (Al{sub 5.8}Si{sub 1.2})(O{sub 1.0}C{sub 3.5}N{sub 1.5}) as a new aluminum silicon oxycarbonitride. > Crystal structure is determined and represented by a split-atom model. > Existence of another new oxycarbonitride (Al{sub 6.6}Si{sub 1.4})(O{sub 0.7}C{sub 4.3}N{sub 2.0}) is demonstrated. > Both new materials are formed by oxidation and nitridation of (Al, Si){sub 6}(O, C){sub 5}.

  20. Different acid-base behaviour of a pyrazole and an isoxazole with organic acids: crystal and molecular structures of the salt 3-(4-fluorophenyl)-1H-pyrazolium 2,4,6-trinitrophenolate and of the cocrystal 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide-3,5-dinitrobenzoic acid (1/1).

    PubMed

    Girisha, Marisiddaiah; Yathirajan, Hemmige S; Jasinski, Jerry P; Glidewell, Christopher

    2016-08-01

    Pyrazole and isoxazole rings differ only in the notional replacement of a potential hydrogen-bond-donor NH unit in pyrazole by a potential hydrogen-bond-acceptor O atom in isoxazole. It is thus of interest to compare the hydrogen-bonding characteristics of these rings. (4-Fluorophenyl)pyrazole undergoes protonation in the presence of 2,4,6-trinitrophenol to yield the salt 3-(4-fluorophenyl)-1H-pyrazolium 2,4,6-trinitrophenolate, C9H8FN2(+)·C6H2N3O7(-), (I), whereas there is no proton transfer between 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide and 3,5-dinitrobenzoic acid, whose reaction gives the 1:1 cocrystal, C11H13N3O3S·C7H4N2O6, (II). The bond lengths in salt (I) provide evidence for aromatic-type delocalization in the pyrazolium ring and for extensive delocalization of the negative charge into the ring of the trinitrophenolate anion. The O atoms of one of the nitro groups in the trinitrophenolate anion are disordered over two sets of atomic sites having occupancies of 0.571 (6) and 0.429 (6), but all of the other substituents on the carbocyclic rings are fully ordered. The ions in salt (I) are linked by an extensive series of N-H...O hydrogen bonds to form a three-dimensional framework structure, and in cocrystal (II), the molecular components are linked by a combination of O-H...N and N-H...O hydrogen bonds to form complex bilayers. Comparisons are made with some related compounds. PMID:27487335