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Sample records for 3 6 9

  1. 9 CFR 3.6 - Primary enclosures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Facilities and Operating Standards § 3.6 Primary enclosures. Primary enclosures for dogs and... they: (i) Have no sharp points or edges that could injure the dogs and cats; (ii) Protect the dogs...

  2. 9 CFR 3.6 - Primary enclosures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Facilities and Operating Standards § 3.6 Primary enclosures. Primary enclosures for dogs and... they: (i) Have no sharp points or edges that could injure the dogs and cats; (ii) Protect the dogs...

  3. 9 CFR 3.6 - Primary enclosures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Facilities and Operating Standards § 3.6 Primary enclosures. Primary enclosures for dogs and... they: (i) Have no sharp points or edges that could injure the dogs and cats; (ii) Protect the dogs...

  4. 9 CFR 3.6 - Primary enclosures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Facilities and Operating Standards § 3.6 Primary enclosures. Primary enclosures for dogs and... they: (i) Have no sharp points or edges that could injure the dogs and cats; (ii) Protect the dogs...

  5. 9 CFR 3.6 - Primary enclosures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Facilities and Operating Standards § 3.6 Primary enclosures. Primary enclosures for dogs and... they: (i) Have no sharp points or edges that could injure the dogs and cats; (ii) Protect the dogs...

  6. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  7. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  8. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  9. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  10. 40 CFR 721.9503 - Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)trimethoxy-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Silane, (3,3,4,4,5,5,6,6,7,7,8,8,9,9... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.9503 Silane, (3,3,4,4,5,5,6,6,7,7,8,8... subject to reporting. (1) The chemical substance identified as silane,...

  11. 3,3,6,6,9,9-Hexaethyl-1,2,4,5,7,8-hexaoxacyclononane at 296 K.

    PubMed

    Cerna, Jorge; Bernès, Sylvain; Cañizo, Adriana; Eyler, Nora

    2009-11-01

    The title molecule (diethyl ketone triperoxide, DEKTP), C(15)H(30)O(6), is a cyclic triperoxide closely related to triacetone triperoxide (TATP), one of the most unstable explosives known. However, the stability of DEKTP is ca 20-50 times greater than that of TATP. DEKTP crystallizes with two molecules in the asymmetric unit, with virtually identical geometry. The cyclononane core is stabilized in a twisted boat-chair conformation (approximate D(3) symmetry), very close to that previously described for TATP. The explanation for the safe thermal behaviour of DEKTP compared with TATP should thus not be sought in the molecular dimensions, but rather in the thermal decomposition kinetics. PMID:19893236

  12. Identification of (3S, 9R)- and (3S, 9S)-megastigma-6,7-dien-3,5,9-triol 9-O-beta-D-glucopyranosides as damascenone progenitors in the flowers of Rosa damascena Mill.

    PubMed

    Suzuki, Masayuki; Matsumoto, Shigetaka; Mizoguchi, Masaya; Hirata, Satoshi; Takagi, Kazuteru; Hashimoto, Ikue; Yamano, Yumiko; Ito, Masayoshi; Fleischmann, Peter; Winterhalter, Peter; Morita, Tetuichiro; Watanabe, Naoharu

    2002-12-01

    The progenitors of damascenone (1), the most intensive C13-norisoprenoid volatile aroma constituent of rose essential oil, were surveyed in the flowers of Rosa damascena Mill. Besides 9-O-beta-D-glucopyranosyl-3-hydroxy-7,8-didehydro-beta-ionol (4b), a stable progenitor already isolated from the residual water after steam distillation of flowers of R. damascena Mill., two labile progenitors were identified to be (3S, 9R)- and (3S, 9S)-megastigma-6,7-dien-3,5,9-triol 9-O-beta-D-glucopyranosides (2b) based on their synthesis and HPLC-MS analytical data. Compound 2b gave damascenone (1), 3-hydroxy-beta-damascone (3) and 4b upon heating under acidic conditions. PMID:12596869

  13. 3,3,6,6-Tetra-methyl-9-[6-(3,3,6,6-tetra-methyl-1,8-dioxo-2,3,4,5,6,7,8,9-octa-hydro-1H-xanthen-9-yl)pyridin-2-yl]-2,3,4,5,6,7,8,9-octa-hydro-1H-xanthene-1,8-dione.

    PubMed

    Abdelhamid, Antar A; Mohamed, Shaaban Kamel; Allahverdiyev, Mirze A; Gurbanov, Atash V; Ng, Seik Weng

    2011-04-01

    In the title mol-ecule, C(39)H(45)NO(6), the two tetra-methyl-octa-hydroxanthen-1,8-dione substituents are arranged approximately parallel to each other and approximately perpendicular to the plane of the pyridine ring. The six-membered xanthene rings adopt flattened boat conformations with the O and methine C atoms deviating from the plane of the other four atoms. PMID:21754076

  14. Bis(9-allyl-6-carb­oxy-9H-carbazole-3-carboxyl­ato-κ2 O 3,O 3′)diaqua­zinc

    PubMed Central

    Li, Dailin

    2012-01-01

    In the title compound, [Zn(C17H12NO4)2(H2O)2], the ZnII atom is located on a twofold rotation axis and is six-coordinated by four carboxyl­ate O atoms from two chelating 9-allyl-6-carb­oxy-9H-carbazole-3-carboxyl­ate ligands and two O atoms from two water mol­ecules. In the crystal, O—H⋯O hydrogen bonds link the mol­ecules into a layer structure parallel to (-101). PMID:23468689

  15. 2,6,9-Trisubstituted purines as CRK3 kinase inhibitors with antileishmanial activity in vitro.

    PubMed

    Řezníčková, Eva; Popa, Alexandr; Gucký, Tomáš; Zatloukal, Marek; Havlíček, Libor; Bazgier, Václav; Berka, Karel; Jorda, Radek; Popa, Igor; Nasereddin, Abdelmajeed; Jaffe, Charles L; Kryštof, Vladimír; Strnad, Miroslav

    2015-06-01

    Here we describe the leishmanicidal activities of a library of 2,6,9-trisubstituted purines that were screened for interaction with Cdc2-related protein kinase 3 (CRK3) and subsequently for activity against parasitic Leishmania species. The most active compound inhibited recombinant CRK3 with an IC50 value of 162 nM and was active against Leishmania major and Leishmania donovani at low micromolar concentrations in vitro. Its mode of binding to CRK3 was investigated by molecular docking using a homology model. PMID:25937014

  16. 2-Azido-1-(3,6-dichloro-9H-fluoren-1-yl)ethanone

    PubMed Central

    Fun, Hoong-Kun; Chia, Tze Shyang; Kayarmar, Reshma; Dinesha; Nagaraja, G. K.

    2011-01-01

    In the title compound, C15H9Cl2N3O, an intra­molecular C—H⋯O inter­action generates an S(7) ring motif. The cyclo­penta-1,3-diene ring forms dihedral angles of 1.93 (6) and 2.78 (6)° with its attached benzene rings. In the crystal, mol­ecules are linked by C—H⋯N and C—H⋯O hydrogen bonds, thereby forming layers lying parallel to the ac plane. The crystal also features a π–π inter­action with a centroid–centroid distance of 3.5612 (6) Å. PMID:22058777

  17. Acoustic features of infant vocalic utterances at 3, 6, and 9 months.

    PubMed

    Kent, R D; Murray, A D

    1982-08-01

    Recordings were obtained of the comfort-state vocalizations of infants at 3, 6, and 9 months of age during a session of play and vocal interaction with the infant's mother and the experimenter. Acoustic analysis, primarily spectrography, was used to determine utterance durations, formant frequencies of vocalic utterances, patterns of f0 frequency change during vocalizations, variations in source excitation of the vocal tract, and general properties of the utterances. Most utterances had durations of less than 400 ms although occasional sounds lasted 2 s or more. An increase in the ranges of both the F1 and F2 frequencies was observed across both periods of age increase, but the center of the F1-F2 plot for the group vowels appeared to change very little. Phonatory characteristics were at least generally compatible with published descriptions of infant cry. The f0 frequency averaged 445 Hz for 3-month-olds, 450 Hz for 6-month-olds, and 415 Hz for 9-month-olds. As has been previously reported for infant cry, the vocalizations frequently were associated with tremor (vibrato), harmonic doubling, abrupt f0 shift, vocal fry (or roll), and noise segments. Thus, from a strictly acoustic perspective, early cry and the later vocalizations of cooing and babbling appear to be vocal performances in continuity. Implications of the acoustic analyses are discussed for phonetic development and speech acquisition. PMID:7119278

  18. Copper Lanthanide Phosphonate Cages: Highly Symmetric {Cu3Ln9P6} and {Cu6Ln6P6} Clusters with C3v and D3h Symmetry.

    PubMed

    Moreno Pineda, Eufemio; Heesing, Christian; Tuna, Floriana; Zheng, Yan-Zhen; McInnes, Eric J L; Schnack, Jürgen; Winpenny, Richard E P

    2015-07-01

    Two families of copper lanthanide phosphonate clusters have been obtained through reaction of [Cu2(O2C(t)Bu)4(HO2C(t)Bu)2] and either Ln(NO3)3·nH2O or [Ln2(O2C(t)Bu)6(HO2C(t)Bu)6] and tert-butylphosphonic acid or an amino-functionalized phosphonic acid. The clusters, with general formula [Cu(MeCN)4][Cu3Ln93-OH)7(O3P(t)Bu)6(O2C(t)Bu)15] and [Cu6Ln63-OH)6(O3PC(NH2)Me2)6(O2C(t)Bu)12], were structurally characterized through single crystal X-ray diffraction and possess highly symmetric metal cores with approximately C3v and D3h point symmetry, respectively. We have investigated the possible application of the isotropic analogues in magnetic cooling, where we were able to observe that up to around 70% of the theoretical magnetic entropy change is obtained. Simulation of the magnetic data shows antiferromagnetic coupling between the spin centers, which explains the magnetic entropy value observed. PMID:26061255

  19. Bromination of pentacyclo(6. 3. 0. 0/sup 2,6/. 0/sup 3,10/. 0/sup 5,9/)undecane

    SciTech Connect

    Sorochinskii, A.E.; Aleksandrov, A.M.; Petrenko, A.E.; Kukhar', V.P.

    1988-03-20

    Previously described methods for the production of derivatives of pentacyclo(6.3.0.0/sup 2,6/.0/sup 3,10/.0/sup 5,9/)undecane (I) (symmetrical trishomocubane) are based on the isomerization of the carbon skeleton in substituted pentacyclo(5.4.0.0/sup 2,6/.0/sup 3,10/.0/sup 5,9/)undecanes by the action of electrophilic reagents. The authors studied the possibility of the direct introduction of a bromine atom into the framework of the hydrogen (I). It was found that trisubane (I), unlike adamantane, does not react with bromine even after prolonged boiling. However, if catalytic amounts of aluminum chloride or bromide are added to the reaction mixture at 20/degree/C, hydrogen bromide is released and 1-bromotrishomocubane (II) is formed. The structure of the bromide (II) was demonstrated.

  20. Process for manufacturing bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene

    SciTech Connect

    Rasmussen, Paul George; Lawton, Richard Graham

    2014-06-03

    A process to manufacture substituted tetracyano-hexaazatricyclics with the substitutions occurring at the 9 and 10 hydrogens. The process begins with 2,3-dichloro-5,6-dicyanopyrazine, which is reacted to form the desired tetracyano-hexaazatricyclic. Different process embodiments enable different reaction paths to the desired tetracyano-hexaazatricyclic. Different tetracyano-hexaazatricyclic embodiments include bis(2-methoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracene and bis(2-methoxyethoxyethyl)-2,3,6,7-tetracyano-1,4,5,8,9,10-hexazaanthracen- e.

  1. 47 CFR 15.251 - Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz. 15.251 Section 15.251 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission...

  2. 47 CFR 15.251 - Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz. 15.251 Section 15.251 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission...

  3. 47 CFR 15.251 - Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz. 15.251 Section 15.251 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission...

  4. 47 CFR 15.251 - Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz. 15.251 Section 15.251 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission...

  5. 47 CFR 15.251 - Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Operation within the bands 2.9-3.26 GHz, 3.267-3.332 GHz, 3.339-3.3458 GHz, and 3.358-3.6 GHz. 15.251 Section 15.251 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Intentional Radiators Radiated Emission...

  6. EQ3/6 software test and verification report 9/94

    SciTech Connect

    Kishi, T.

    1996-02-01

    This document is the Software Test and Verification Report (STVR) for the EQ3/6 suite of codes as stipulated in the Individual Software Plan for Initial Qualification of EQ3/6 (ISP-NF-07, Revision 1, 11/25/92). The software codes, EQPT, EQ3NR, EQ6, and the software library EQLIB constitute the EQ3/6 software package. This software test and verification project for EQ3/6 was started under the requirements of the LLNL Yucca Mountain Project Software Quality Assurance Plan (SQAP), Revision 0, December 14, 1989, but QP 3.2, Revision 2, June 21, 1994 is now the operative controlling procedure. This is a ``V and V`` report in the language of QP 3.2, Revision 2. Because the author of this report does not have a background in geochemistry, other technical sources were consulted in order to acquire some familiarity with geochemisty, the terminology minology involved, and to review comparable computational methods especially, geochemical aqueous speciation-solubility calculations. The software for the EQ3/6 package consists of approximately 47,000 lines of FORTRAN77 source code and nine on platforms ranging from workstations to supercomputers. The physical control of EQ3/6 software package and documentation is on a SUN SPARC station. Walkthroughs of each principal software packages, EQPT, EQ3NR, and EQ6 were conducted in order to understand the computational procedures involved, to determine any commonality in procedures, and then to establish a plan for the test and verification of EQ3/6. It became evident that all three phases depended upon solving an n x n matrix by the Newton-Raphson Method. Thus, a great deal of emphasis on the test and verification of this procedure was carried out on the first code in the software package EQPT.

  7. Luminescence properties of Ba3Si6O9N4:Eu2+ green-emitting phosphors for white LEDs

    NASA Astrophysics Data System (ADS)

    Yu, Lanlan; Hua, Youjie; Chen, Hong; Deng, Degang; Wang, Huanping; Ma, Hongping; Xu, Shiqing

    2014-03-01

    A green-emitting phosphor, Eu2+-activated Ba3Si6O9N4 phosphor, was synthesized by a conventional solid state reaction method. X-ray diffraction patterns showed that the synthesized phosphor sintered at 1300 °C for 6 h was a Ba3Si6O9N4 pure phase. It could be efficiently excited by UV-blue light (280-500 nm) and showed a single intense broad emission band (470-625 nm). Suitable excitation range makes it match well with the emission of near-UV or blue LEDs. Concentration quenching of the doped-Eu2+ ions occurred at x=0.15, and the critical distance is calculated to be about 1.807 nm by theory of energy transfer. The result indicates that Ba3Si6O9N4:Eu2+ is a promising green-emitting phosphor for white LEDs.

  8. An Interaction between RRP6 and SU(VAR)3-9 Targets RRP6 to Heterochromatin and Contributes to Heterochromatin Maintenance in Drosophila melanogaster.

    PubMed

    Eberle, Andrea B; Jordán-Pla, Antonio; Gañez-Zapater, Antoni; Hessle, Viktoria; Silberberg, Gilad; von Euler, Anne; Silverstein, Rebecca A; Visa, Neus

    2015-09-01

    RNA surveillance factors are involved in heterochromatin regulation in yeast and plants, but less is known about the possible roles of ribonucleases in the heterochromatin of animal cells. Here we show that RRP6, one of the catalytic subunits of the exosome, is necessary for silencing heterochromatic repeats in the genome of Drosophila melanogaster. We show that a fraction of RRP6 is associated with heterochromatin, and the analysis of the RRP6 interaction network revealed physical links between RRP6 and the heterochromatin factors HP1a, SU(VAR)3-9 and RPD3. Moreover, genome-wide studies of RRP6 occupancy in cells depleted of SU(VAR)3-9 demonstrated that SU(VAR)3-9 contributes to the tethering of RRP6 to a subset of heterochromatic loci. Depletion of the exosome ribonucleases RRP6 and DIS3 stabilizes heterochromatic transcripts derived from transposons and repetitive sequences, and renders the heterochromatin less compact, as shown by micrococcal nuclease and proximity-ligation assays. Such depletion also increases the amount of HP1a bound to heterochromatic transcripts. Taken together, our results suggest that SU(VAR)3-9 targets RRP6 to a subset of heterochromatic loci where RRP6 degrades chromatin-associated non-coding RNAs in a process that is necessary to maintain the packaging of the heterochromatin. PMID:26389589

  9. An Interaction between RRP6 and SU(VAR)3-9 Targets RRP6 to Heterochromatin and Contributes to Heterochromatin Maintenance in Drosophila melanogaster

    PubMed Central

    Eberle, Andrea B.; Jordán-Pla, Antonio; Gañez-Zapater, Antoni; Hessle, Viktoria; Silberberg, Gilad; von Euler, Anne; Silverstein, Rebecca A.; Visa, Neus

    2015-01-01

    RNA surveillance factors are involved in heterochromatin regulation in yeast and plants, but less is known about the possible roles of ribonucleases in the heterochromatin of animal cells. Here we show that RRP6, one of the catalytic subunits of the exosome, is necessary for silencing heterochromatic repeats in the genome of Drosophila melanogaster. We show that a fraction of RRP6 is associated with heterochromatin, and the analysis of the RRP6 interaction network revealed physical links between RRP6 and the heterochromatin factors HP1a, SU(VAR)3-9 and RPD3. Moreover, genome-wide studies of RRP6 occupancy in cells depleted of SU(VAR)3-9 demonstrated that SU(VAR)3-9 contributes to the tethering of RRP6 to a subset of heterochromatic loci. Depletion of the exosome ribonucleases RRP6 and DIS3 stabilizes heterochromatic transcripts derived from transposons and repetitive sequences, and renders the heterochromatin less compact, as shown by micrococcal nuclease and proximity-ligation assays. Such depletion also increases the amount of HP1a bound to heterochromatic transcripts. Taken together, our results suggest that SU(VAR)3-9 targets RRP6 to a subset of heterochromatic loci where RRP6 degrades chromatin-associated non-coding RNAs in a process that is necessary to maintain the packaging of the heterochromatin. PMID:26389589

  10. Protective efficacy of Anopheles minimus CYP6P7 and CYP6AA3 against cytotoxicity of pyrethroid insecticides in Spodoptera frugiperda (Sf9) insect cells.

    PubMed

    Duangkaew, P; Kaewpa, D; Rongnoparut, P

    2011-08-01

    Cytochrome P450 monooxygenases (P450s) are enzymes known to metabolize a wide variety of compounds including insecticides. Their overexpression leading to enhanced insecticide detoxification could result in insecticide resistance in insects. The increased mRNA expression of two P450 genes, CYP6P7 and CYP6AA3, has been previously observed in laboratory-selected deltamethrin-resistant Anopheles minimus, a major malaria vector in Southeast Asia, suggesting their role in detoxification of pyrethroids. In this study CYP6P7 and CYP6AA3 were expressed in insect Spodoptera frugiperda (Sf9) cells via baculovirusdirected expression system. Insecticide detoxification capabilities of Sf9 cells with and without expression of CYP6P7 or CYP6AA3 were evaluated using 3-(4,5-dimethyl-thiazol-2- yl)-2,5-diphenyltetrazolium bromide (MTT) assays. The results revealed that CYP6P7- or CYP6AA3-expressing cells showed significantly higher cytoprotective capability than parental Sf9 cells against cytotoxicity of pyrethroids including permethrin, cypermethrin and deltamethrin. Such cytoprotective effect was not observed for bioallethrin (pyrethroid), chlorpyrifos (organophosphate) and propoxur (carbamate). Moreover, expression of CYP6AA3, but not CYP6P7, could protect cells against λ-cyhalothrin cytotoxicity. In MTT assays upon co-incubation with piperonyl butoxide (P450 inhibitor), cytoprotective ability of CYP6P7 and CYP6AA3 against deltamethrin was diminished, implying that pyrethroid detoxification was due to activities of P450 enzymes. Insecticide detoxification capabilities of CYP6P7 and CYP6AA3 observed from MTT assays were correlated to their pyrethroid metabolizing activities observed from in vitro reconstitution enzymatic assays. Thus MTT assays using cells expressing P450 enzymes of interest could be primarily used to determine detoxification activities of enzymes against cytotoxic insecticides. PMID:22041748

  11. Theoretical vibrations of carbon chains C3, C4, C5, C6, C7, C8, and C9

    NASA Technical Reports Server (NTRS)

    Kurtz, Joe; Adamowicz, Ludwik

    1991-01-01

    The MBPT (2) procedure with the 6-31g (asterisk) basis set was used to study nearly linear carbon chains. The theoretical vibrational frequencies of the molecules C3 through C9 are presented and, for C3 through C6, compared to experimental stretching frequencies and their (C-13)/(C-12) isotopomers. Predictions for C7, C8, and C9 stretching frequencies are calculated by directly scaling the theoretical frequencies with factors derived from experimental-to-theoretical ratios known for the smaller molecules.

  12. Synthesis and photosensitivity characterizations of 9-(6-bromo-4-oxo-4H-chromen-3-yl)-3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-2H-xanthene-1,8-(5H,9H)-dione(BOCTTX)

    NASA Astrophysics Data System (ADS)

    Ibrahim, Magdy A.; Farag, A. A. M.; Roushdy, N.; El-Gohary, Nasser M.

    2016-02-01

    Condensation reaction of 6-bromochromone-3-carboxaldehyde (1) with dimedone afforded 9-(6-bromo-4-oxo-4H-chromen-3-yl)-3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-2H-xanthene-1,8-(5H,9H)-dione (3, BOCTTX). Structure of BOCTTX was deduced based on its correct elemental analysis and spectral data (IR, 1H NMR, 13C NMR and mass spectra). Thin films of BOCTTX were prepared in this study by using spin coating technique. X-ray diffraction, scanning electron microscope analysis were studied for study the crystal and morphology characterization of BOCTTX. The results indicate that BOCTTX has a polycrystalline nature with monoclinic structure. From differential scanning calorimetry, BOCTTX is found to be thermally stable up to 583 K and the chemical structure plays an important role in the thermal decomposition process. The optical absorption of the film was studied in the UV-Vis spectral range and the value of two allowed energy gaps of 2.2 and 3.3 eV. Current-voltage characteristics of BOCTTX based devices were studied in dark and under various illumination intensities in the range 20-100 mW/cm2. Electrical and photoelectrical parameters were studied as a function of light intensity. The obtained results exhibits photoconductivity cauterization and suggest that the diode can be used as a photodiode in optoelectronic sensor application.

  13. Hydrothermal synthesis and characterization of the first mixed alkali borate-nitrate K3Na[B6O9(OH)3]NO3

    NASA Astrophysics Data System (ADS)

    Ortner, Teresa S.; Wurst, Klaus; Perfler, Lukas; Tribus, Martina; Huppertz, Hubert

    2015-01-01

    The first mixed alkali borate-nitrate K3Na[B6O9(OH)3]NO3 was synthesized under hydrothermal conditions from Na2B4O7·10H2O and K2B4O7·4H2O using KNO3 as a nitrate source. The compound crystallizes in the space group Pnnm (no. 58) with the lattice parameters a=1320.8(3), b=910.7(2), and c=1232.5(3) pm (Z=4). Isolated Sechserrings formed by BO4 and BO3 groups are linked through hydrogen bridges to form a three-dimensional network.

  14. 6-(3,5-Dimeth-oxy-benzyl-amino)-9-(oxan-2-yl)-9H-purine.

    PubMed

    Starha, Pavel; Popa, Igor; Dvořák, Zdeněk; Trávníček, Zdeněk

    2013-04-01

    The mol-ecule of the title compound, C19H23N5O3, contains six-membered pyrimidine and five-membered imidazole rings merged into the essentially planar purine skeleton (r.m.s. deviation = 0.01 Å). In the crystal, pairs of N-H⋯N hydrogen bonds link mol-ecules into inversion dimers. The dimers are linked via C-H⋯O hydrogen bonds, forming double-stranded chains propagating along [001]. These chains are linked via C-H⋯π and parallel slipped π-π inter-actions [centroid-centroid distance = 3.467 (1) Å; slippage 0.519 Å], forming a three-dimensional network. PMID:23634074

  15. 6-(3,5-Dimeth­oxy­benzyl­amino)-9-(oxan-2-yl)-9H-purine

    PubMed Central

    Štarha, Pavel; Popa, Igor; Dvořák, Zdeněk; Trávníček, Zdeněk

    2013-01-01

    The mol­ecule of the title compound, C19H23N5O3, contains six-membered pyrimidine and five-membered imidazole rings merged into the essentially planar purine skeleton (r.m.s. deviation = 0.01 Å). In the crystal, pairs of N—H⋯N hydrogen bonds link mol­ecules into inversion dimers. The dimers are linked via C—H⋯O hydrogen bonds, forming double-stranded chains propagating along [001]. These chains are linked via C—H⋯π and parallel slipped π–π inter­actions [centroid–centroid distance = 3.467 (1) Å; slippage 0.519 Å], forming a three-dimensional network. PMID:23634074

  16. 3,3,6,6-Tetra­methyl-9-[6-(3,3,6,6-tetra­methyl-1,8-dioxo-2,3,4,5,6,7,8,9-octa­hydro-1H-xanthen-9-yl)pyridin-2-yl]-2,3,4,5,6,7,8,9-octa­hydro-1H-xanthene-1,8-dione

    PubMed Central

    Abdelhamid, Antar A.; Mohamed, Shaaban Kamel; Allahverdiyev, Mirze A.; Gurbanov, Atash V.; Ng, Seik Weng

    2011-01-01

    In the title mol­ecule, C39H45NO6, the two tetra­methyl­octa­hydroxanthen-1,8-dione substituents are arranged approximately parallel to each other and approximately perpendicular to the plane of the pyridine ring. The six-membered xanthene rings adopt flattened boat conformations with the O and methine C atoms deviating from the plane of the other four atoms. PMID:21754076

  17. Hematoxylin substitutes: fluorone black and methyl fluorone black (9-phenyl- and 9-methyl-2,3,7-trihydroxy-6-fluorone) as metachrome iron alum mordant dyes.

    PubMed

    Lillie, R D; Pizzolato, P; Donaldson, P T

    1975-03-01

    The phenyl and methyl trihydroxyfluorones, hitherto used histologically only in the rather difficult and unreliable Turchini technics for discriminating deoxyribonucleic from ribonucleic acid, find a new use as iron mordant metachrome dyes which act as nuclear stains. Nuclear staining is unaffected by acid extraction of nucleic acids, as with hematoxylin lakes. The two dyes, named by Liebermann and Lindenbaum 9-phenyl-2, 3, 7-trihydroxy-6-fluorone, have also acquired (illustrating with the phenyl homolog) longer chemical names of the form 2,6,7-trihydroxy-9-phenylisoxanthene-3-one (Eastman). Aldrich and Pfalz-Bauer adhere to the Liebermann-Lindenbaum nomenclature. The trivial name fluorone black is proposed for the phenyl homolog and methyl fluorone black for the methyl homolog. The iron lake of fluorone black appears to be a useful substitute for iron hematoxylin, methyl flurone black less useful. Neither dye has the diverse capability of hematoxylin. PMID:49945

  18. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H{sub 2} hydrogenation reaction network.

  19. Tricyclo­[6.2.1.02,7]undeca-4,9-diene-3,6-dione

    PubMed Central

    Wang, Chongchen

    2008-01-01

    The title compound, C11H10O2, crystallizes with two independent mol­ecules in the asymmetric unit. In one mol­ecule, the dihedral angle between the mean planes of the C—C=C—C group of the diene unit and essentially planar cyclo­hexene ring is 51.07 (9)°, while in the other mol­ecule it is 54.49 (12)°. In the crystal structure, weak inter­molecular C—H⋯O inter­actions link the mol­ecules into columns along the b axis. PMID:21201200

  20. trans-Dichloridobis{2-chloro-6-[(3-fluoro-benz-yl)amino]-9-isopropyl-9H-purine-κN (7)}platinum(II).

    PubMed

    Trávníček, Zdeněk; Starha, Pavel

    2013-06-01

    In the title compound, trans-[PtCl2(C15H15ClFN5)2], the Pt(II) atom, located on an inversion centre, is coordinated by the purine N atoms of the 2-chloro-6-[(3-fluoro-benz-yl)amino]-9-isopropyl-9H-purine ligands and two Cl atoms in a slightly distorted trans-square-planar coordination geometry [N-Pt-Cl angles = 89.91 (5) and 90.09 (5)°]. Weak intra-molecular N-H⋯Cl contacts occur. In the crystal, C-H⋯Cl and C-H⋯F contacts, as well as weak π-π stacking inter-actions [centroid-centroid distances = 3.5000 (11) and 3.6495 (12) Å] connect the mol-ecules into a three-dimensional architecture. PMID:23794993

  1. trans-Dichloridobis{2-chloro-6-[(3-fluoro­benz­yl)amino]-9-isopropyl-9H-purine-κN 7}platinum(II)

    PubMed Central

    Trávníček, Zdeněk; Štarha, Pavel

    2013-01-01

    In the title compound, trans-[PtCl2(C15H15ClFN5)2], the PtII atom, located on an inversion centre, is coordinated by the purine N atoms of the 2-chloro-6-[(3-fluoro­benz­yl)amino]-9-isopropyl-9H-purine ligands and two Cl atoms in a slightly distorted trans-square-planar coordination geometry [N—Pt—Cl angles = 89.91 (5) and 90.09 (5)°]. Weak intra­molecular N—H⋯Cl contacts occur. In the crystal, C—H⋯Cl and C—H⋯F contacts, as well as weak π–π stacking inter­actions [centroid–centroid distances = 3.5000 (11) and 3.6495 (12) Å] connect the mol­ecules into a three-dimensional architecture. PMID:23794993

  2. Modeling Rdamage-6 through -9

    SciTech Connect

    Kaul, Ann

    2012-06-13

    The RDamage series of ten experiments is part of a long-term collaboration with RFNC/VNIIEF in pulsed power technology. These experiments use a cylindrical configuration to study spallation damage, which allows for a natural recollection of the damaged material under proper driving conditions and post-shot collection of the damaged target material for subsequent metallographic analysis. Dynamic in-situ experimental velocimetry diagnostics are also employed. LANL is responsible for the design of the experimental load and velocimetry system. VNIIEF is responsible for the design and construction of the driving explosive magnetic generator. In the RDamage-0, -1 and -2 experiments, data was collected about failure initiation of a well-characterized material (aluminum) in a cylindrical geometry. The RDamage-3, -4 and -5 experiments produced data on the behavior of material recollected after damage from pressures in the damage initiation regime. Data on the behavior of material recollected after complete failure was collected in the RDamage-6, -7, -8 and -9 experiments. This presentation shows the recent LANL simulation results for RD-6 through -9.

  3. High-precision Photometric Redshifts from Spitzer/IRAC: Extreme [3.6] - [4.5] Colors Identify Galaxies in the Redshift Range z ˜ 6.6 - 6.9

    NASA Astrophysics Data System (ADS)

    Smit, Renske; Bouwens, Rychard J.; Franx, Marijn; Oesch, Pascal A.; Ashby, Matthew L. N.; Willner, S. P.; Labbé, Ivo; Holwerda, Benne; Fazio, Giovanni G.; Huang, J.-S.

    2015-03-01

    One of the most challenging aspects of studying galaxies in the z≳ 7 universe is the infrequent confirmation of their redshifts through spectroscopy, a phenomenon thought to occur from the increasing opacity of the intergalactic medium to Lyα photons at z\\gt 6.5. The resulting redshift uncertainties inhibit the efficient search for [C ii] in z˜ 7 galaxies with sub-millimeter instruments such as ALMA, given their limited scan speed for faint lines. One means by which to improve the precision of the inferred redshifts is to exploit the potential impact of strong nebular emission lines on the colors of z ˜ 4 - 8 galaxies as observed by Spitzer/IRAC. At z˜ 6.8, galaxies exhibit IRAC colors as blue as [3.6]-[4.5]˜ -1, likely due to the contribution of [O iii]+Hβ to the 3.6 μm flux combined with the absence of line contamination in the 4.5 μm band. In this paper we explore the use of extremely blue [3.6]-[4.5] colors to identify galaxies in the narrow redshift window z ˜ 6.6 - 6.9. When combined with an I-dropout criterion, we demonstrate that we can plausibly select a relatively clean sample of z˜ 6.8 galaxies. Through a systematic application of this selection technique to our catalogs from all five CANDELS fields, we identify 20 probable z ˜ 6.6 - 6.9 galaxies. We estimate that our criteria select the ˜50% strongest line emitters at z˜ 6.8 and from the IRAC colors we estimate a typical [O iii]+Hβ rest-frame equivalent width of 1085 Å for this sample. The small redshift uncertainties on our sample make it particularly well suited for follow-up studies with facilities such as ALMA.

  4. 3′,6′-Bis(diethyl­amino)-2-phenyl­spiro[isoindoline-1,9′-xanthen]-3-one

    PubMed Central

    Deng, Wu-Jian; Sun, Di; Su, Bing-Yuan; Wang, Shu-Ping; Zheng, Hong

    2009-01-01

    The title compound, C34H35O2N3, was synthesized by the reaction of 2-[3,6-bis­(diethyl­amino)-9H-xanthen-9-yl]benzoyl chloride with aniline. In the mol­ecular structure, the dihedral angles between the isoindoline and xanthene planes and between the isoindoline and benzene planes are 86.9 (3) and 47.0 (2)°, respectively. The mol­ecular packing in the crystal structure is stabilized by weak C—H⋯O hydrogen bonding. PMID:21582767

  5. 6H hexagonal structure of low loss Ba{sub 3}MTiWO{sub 9} (M = Mg, Zn) dielectrics

    SciTech Connect

    Khalyavin, D.D.

    2007-01-18

    The crystal structure of Ba{sub 3}MTiWO{sub 9} (M = Mg, Zn) oxides has been found to be 6H hexagonal, space group P6{sub 3}/mmc, parameters of unit cell: a = 5.7943(1) A, c = 14.1642(1) A and a = 5.7993(1) A, c = 14.1626(1) A for M = Mg and Zn, respectively. The tungsten and titanium atoms are randomly distributed in pairs of face-sharing octahedra separated by octahedral layers containing magnesium or zinc. It was revealed that the structures are well ordered which is believed to result in a low dielectric loss at a microwave frequency reported for these materials.

  6. Crystal structure and computational study of 3,4-dihy-droxy-3-hy-droxy-methyl-9-methyl-6-methyl-idene-3a,4,5,6,6a,9,9a,9b-octa-hydro-azuleno[4,5-b]furan-2,8(3H,7H)-dione.

    PubMed

    Çelik, Ísmail; Akkurt, Mehmet; Akşit, Hüseyin; Erenler, Ramazan; García-Granda, Santiago

    2015-12-01

    In the mol-ecule of title compound, C15H20O6, also known as cynarinin A, the cyclo-pentane ring having twist conformation and a γ-lactone ring assuming an envelope conformation are trans- and cis-fused, respectively, to a cyclo-heptane ring adopting a twist-chair conformation. In the crystal, O-H⋯O hydrogen bonds link neighbouring mol-ecules, forming a three-dimensional network. Theoretical calculations of the mol-ecular structure using the CNDO approximation and MOPAC PM3 geometry optimization are in satisfactory agreement with the results of the X-ray structure analysis. PMID:26870396

  7. Luminescence intensity enhancement of Eu2+ and Eu3+ by Tb3+ in LiLa9(SiO4)6O2

    NASA Astrophysics Data System (ADS)

    Xie, Mubiao; Zhu, Guoxian; Pan, Rongkai; Li, Dongyu; Hou, Dejian

    2016-06-01

    Novel yellow-emitting phosphors LiLa9(SiO4)6O2: 0.05Eu, xTb (x  =  0, 0.01, 0.03, 0.02, 0.04, 0.06, 0.08, 0.10) were prepared by a solid-state reaction in a CO-reducing atmosphere. The excitation and emission spectra, and the fluorescence decays were measured and discussed in detail. The fluorescence spectra results of sample LiLa9(SiO4)6O2: 0.05Eu reveal that still a small amount of Eu3+ ions are detected in the LiLa9(SiO4)6O2 host. The introduction of Tb3+ ions can enhance the emission intensity of LiLa9(SiO4)6O2: 0.05Eu under near-ultraviolet light excitation but they do not vary the emission color much. The results indicate that the yellow-emitting phosphors LiLa9(SiO4)6O2: Eu, Tb can be considered as potential phosphor-converted materials for n-UV white light-emitting diodes.

  8. Crystal structure and computational study of 3,4-dihy­droxy-3-hy­droxy­methyl-9-methyl-6-methyl­idene-3a,4,5,6,6a,9,9a,9b-octa­hydro­azuleno[4,5-b]furan-2,8(3H,7H)-dione

    PubMed Central

    Çelik, Ísmail; Akkurt, Mehmet; Akşit, Hüseyin; Erenler, Ramazan; García-Granda, Santiago

    2015-01-01

    In the mol­ecule of title compound, C15H20O6, also known as cynarinin A, the cyclo­pentane ring having twist conformation and a γ-lactone ring assuming an envelope conformation are trans- and cis-fused, respectively, to a cyclo­heptane ring adopting a twist-chair conformation. In the crystal, O—H⋯O hydrogen bonds link neighbouring mol­ecules, forming a three-dimensional network. Theoretical calculations of the mol­ecular structure using the CNDO approximation and MOPAC PM3 geometry optimization are in satisfactory agreement with the results of the X-ray structure analysis. PMID:26870396

  9. Hierarchical cobalt-formate framework series with (4{sup 12}⋅6{sup 3})(4{sup 9}⋅6{sup 6}){sub n} (n = 1–3) topologies exhibiting slow dielectric relaxation and weak ferromagnetism

    SciTech Connect

    Shang, Ran; Chen, Sa; Hu, Ke-Li; Jiang, Ze-Chun; Wang, Bing-Wu; Wang, Zhe-Ming E-mail: gaosong@pku.edu.cn; Gao, Song E-mail: gaosong@pku.edu.cn; Kurmoo, Mohamedally

    2014-12-01

    The employment of linear di-, tri-, and tetra-ammoniums has generated a hierarchy in the binodal (4{sup 12}⋅6{sup 3})(4{sup 9}⋅6{sup 6}){sub n} topologies with n = 1, 2, and 3, respectively, for the cobalt formate frameworks with increasing length of the cavities to match the ammoniums. This indicates the length-directing effect of the polyammoniums. The dynamic movements of polyammoniums between favored sites or orientations within the cavities lead to slow dielectric relaxations. All materials are spin-canted antiferromagnets in low temperatures and show reduced spontaneous magnetizations from di- and tri-, to tetra-ammoniums, because of the increased number of unique Co ions or the antiferromagnetically coupled sublattices.

  10. The Other-Race Effect in a Longitudinal Sample of 3-, 6- and 9-Month-Old Infants: Evidence of a Training Effect

    ERIC Educational Resources Information Center

    Spangler, Sibylle M.; Schwarzer, Gudrun; Freitag, Claudia; Vierhaus, Marc; Teubert, Manuel; Fassbender, Ina; Lohaus, Arnold; Kolling, Thorsten; Graf, Frauke; Goertz, Claudia; Knopf, Monika; Lamm, Bettina; Keller, Heidi

    2013-01-01

    We investigated the development of the other-race effect "ORE" in a longitudinal sample of 3-, 6-, and 9-month-old Caucasian infants. Previous research using cross-sectional samples has shown an unstable ORE at 3 months, an increase at 6 months and full development at 9 months. In Experiment 1, we tested whether 9-month-olds showed the…

  11. The ionothermal synthesis of metal organic frameworks, Ln(C 9O 6H 3)((CH 3NH) 2CO) 2, using deep eutectic solvents

    NASA Astrophysics Data System (ADS)

    Himeur, Farida; Stein, Irene; Wragg, David S.; Slawin, Alexandra M. Z.; Lightfoot, Philip; Morris, Russell E.

    2010-04-01

    Three new isostructural materials Ln(TMA)(DMU) 2 (Ln(C 9O 6H 3)((CH 3NH) 2CO) 2; Ln: La 1, Nd 2, Eu 3; TMA: trimesate, DMU: dimethylurea) have been synthesised ionothermally using a choline chloride/dimethylurea deep eutectic mixture as the solvent. Normally in ionothermal synthesis the urea portion of the deep eutectic solvent is unstable, breaking down to release ammonium cations that act as templates. In the case of 1- 3, however, the dimethylurea remains intact and is incorporated into the final structure.

  12. Crystal structure of (1S,3R,8R,9R)-2,2-di-chloro-3,7,7-tri-methyl-10-methylenetri-cyclo-[6.4.0.0(1,3)]dodecan-9-ol.

    PubMed

    Benzalim, Ahmed; Auhmani, Aziz; Bimoussa, Abdoullah; Ait Itto, My Youssef; Daran, Jean-Claude; Auhmani, Abdelwahed

    2016-08-01

    The title compound, C16H24Cl2O, was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di-chloro-3,7,7,10-tetra-methyl-9,10-ep-oxy-tri-cyclo-[6.4.0.0(1,3)]dodecane with a concentrated solution of hydro-bromic acid. It is built up from three fused rings: a cyclo-heptane ring, a cyclo-hexyl ring bearing alkene and hy-droxy substituents, and a cyclo-propane ring bearing two chlorine atoms. The asymmetric unit contains two mol-ecules linked by an O-H⋯O hydrogen bond. In the crystal, further O-H⋯O hydrogen bonds build up an R 4 (4)(8) cyclic tetra-mer. One of the mol-ecules presents disorder that affects the seven-membered ring. In both mol-ecules, the six-membered rings display a chair conformation, whereas the seven-membered rings display conformations inter-mediate between boat and twist-boat for the non-disordered mol-ecule and either a chair or boat and twist-boat for the disordered mol-ecule owing to the disorder. The absolute configuration for both mol-ecules is 1S,3R,8R,9R and was deduced from the chemical pathway and further confirmed by the X-ray structural analysis. PMID:27536404

  13. A simple and efficient approach to the synthesis of endo and exo bicyclo[6.1.0]nona-3,5-diene-9-carboxaldehyde.

    PubMed

    Ghandi, Mehdi; Mashayekhi, Gholamreza

    2007-01-01

    Monobromination of 1,5-cyclooctadiene, followed by cyclopropanation with ethyl diazoacetate, led to the formation of endo and exo ethyl 4,5-dibromobicyclo[6.1.0]nonane-9-carboxylates 3a and 3b. Bis-dehydrobromination of 3a and 3b using 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU) afforded the endo and exo ethyl bicyclo[6.1.0]nona-3,5-diene-9-carboxylates 4a and 4b. Reduction of these compounds to the corresponding alcohols 5a and 5b and subsequent oxidation with pyridinium chlorochromate (PCC) resulted in the formation of the target compounds endo and exo bicyclo[6.1.0]nona-3,5-diene-9-carboxaldehydes 6a and 6b. PMID:17978767

  14. Crystal structure of (+)-N-[(1R,5S,6S,9S)-5-hydroxy-methyl-3,3,9-trimethyl-8-oxo-2,4,7-trioxabi-cyclo-[4.3.0]nonan-9-yl]acetamide.

    PubMed

    Oishi, Takeshi; Tsuzaki, Shun; Sugai, Tomoya; Sato, Takaaki; Chida, Noritaka

    2016-05-01

    In the title compound, C12H19NO6, the six-membered 1,3-dioxane ring adopts a chair-like conformation. The seat of this chair, containing two O atoms, is essentially planar, with a maximum deviation of 0.0021 (12) Å. The five-membered oxolane ring cis-fused to the 1,3-dioxane ring adopts an envelope form. The bridgehead C atom at the flap, which is bonded to the tetra-substituted C atom of the oxolane ring, deviates from the mean plane of other ring atoms by 0.539 (4) Å. In the crystal, classical O-H⋯O and N-H⋯O hydrogen bonds link the mol-ecules into a sheet structure enclosing an R 4 (4)(24) graph-set motif. Weak inter-molecular C-H⋯O inter-actions support the sheet formation. PMID:27308035

  15. Bilateral key comparison CCM.P-K3.1 for absolute pressure measurements from 3 × 10-6 Pa to 9 × 10-4 Pa

    NASA Astrophysics Data System (ADS)

    Fedchak, J. A.; Bock, Th; Jousten, K.

    2014-01-01

    This report describes the bilateral key comparison CCM.P-K3.1 between the National Institute of Standards and Technology (NIST) and Physikalisch-Technische Bundesanstalt (PTB) for absolute pressure in the range from 3 × 10-6 Pa to 9 × 10-4 Pa. This comparison was a follow-up to the comparison CCM.P-K3. Two ionization gauges and two spinning rotor gauges (SRGs) were used as the transfer standards for the comparison. The SRGs were used to compare the standards at a pressure of 9 × 10-4 Pa and to normalize the ionization gauge readings. The two ionization gauges were used to compare the standards in the pressure range of from 3 × 10-6 Pa to 3 × 10-4 Pa. Both laboratories used dynamic expansion chambers as standards in the comparison. The two labs showed excellent agreement with each other and with the CCM.P-K3 key comparison reference value (KCRV) over the entire range. Main text. To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/. The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).

  16. Synthesis and structure elucidation of potential 6-oxygenated metabolites of (22R)-6alpha,9alpha-difluoro-11beta,21-dihydroxy-1 6alpha,17alpha-propyl methylenedioxypregn-4-ene-3,20-dione, and related glucocorticosteroids.

    PubMed

    Thalén, A; Wickström, L I

    2000-01-01

    (22R)-6alpha,9alpha-Difluoro-11beta,21-dihydroxy-16 alpha,17alpha-propylmethylenedioxypregn-4-ene-3,20-dione (rofleponide) is a synthetic glucocorticosteroid with high affinity for the rat thymus glucocorticoid receptor and a very high biotransformation rate demonstrated through incubation with a human liver S9 subcellular fraction. Because oxidation in the 6-position is an important metabolic pathway of glucocorticosteroids, the potential 6beta-hydroxy and 6-oxo metabolites of rofleponide were synthesized to be used as reference compounds. Three alternative routes were used to reach the 6-hydroxy compound: (a) a one-step procedure involving allylic oxidation of rofleponide by selenium dioxide, (b) selenium dioxide oxidation of the corresponding 1,4-diene followed by selective 1,2-hydrogenation using Wilkinson's catalyst, and (c) autoxidation of a 3-methoxypregna-3,5-diene derivative. All three routes proceeded stereospecifically. Routes (a) and (c) gave approximately the same overall yield of the 6beta-hydroxy epimer, whereas the overall yield from route (b) was much lower, primarily because of incomplete 1,2-hydrogenation. The 6-oxo compound was prepared through Pfitzner/Moffat oxidation of the 6-hydroxy compound. The stereochemistry of the 6-hydroxy substituent is discussed on the basis of 1H-NMR spectroscopy and supplementary 2D NOESY experiments. PMID:10624832

  17. Spectrometric measurements and DFT studies on new complex of copper (II) with 2-((E)-9-ethyl-3-(2-(6-(4-methylpyridin-2-yl)pyridin-3-yl)vinyl)-9H-carbazole.

    PubMed

    Zhang, Haoyang; Hu, Jie; Zhao, Jianying; Zhang, Yu

    2016-11-01

    The molecular structure of a new complex of copper (II) with (E)-9-ethyl-3-(2-(6-(4-methylpyridin-2-yl)pyridin-3-yl)vinyl)-9H-carbazole ([Cu2(emppc)2Cl2]Cl2) was optimized with B3LYP/LanL2DZ, PBE1PBE/LanL2DZ and M062X/LanL2DZ theoretical level. The ligand, (E)-9-ethyl-3-(2-(6-(4-methylpyridin-2-yl)pyridin-3-yl)vinyl)-9H-carbazole (emppc), binds to Cu(II) ions with a bi-dentate mode, two Cl(-) serve as bridging ligand, each Cu(II) ion has a highly distorted tetrahedron coordination geometry. With M062X/LanL2DZ theoretical level, the calculated interaction energies of Cu(II) with coordination atoms N are between 183.3-200.0kJmol(-1) for α spin and 319.4-324.9kJmol(-1) for β spin, and interaction energies of Cu(II) with coordination atoms Cl atom are 248.0-252.4kJmol(-1) for α spin and 332.6-333.6kJmol(-1) for β spin. The experimental Fourier transform infrared spectrum was assigned. The calculated IR based on B3LYP/LanL2DZ, PBE1PBE/LanL2DZ and M062X/LanL2DZ methods were performed and compared with experimental results. The UV-Vis experimental spectra of [Cu2(emppc)2Cl2]Cl2 was measured in methanol solution. The calculated electronic spectrum was performed with TD/M062X and PCM-TD/M062X methods with LanL2DZ basis set. The nature bond orbital analysis and temperature dependence of the thermodynamic properties were calculated with the same methods. PMID:27285472

  18. Traceable stopping cross sections of Al and Mo elemental targets for 0.9-3.6-MeV protons

    NASA Astrophysics Data System (ADS)

    Moro, M. V.; Silva, T. F.; Mangiarotti, A.; Guimarães-Filho, Z. O.; Rizzutto, M. A.; Added, N.; Tabacniks, M. H.

    2016-02-01

    Accurate knowledge about the energy loss of ions in matter is essential in many problems, ranging from fundamental to applied nuclear physics. Indeed, there is a recent and increasing demand for new data on stopping cross sections measured with high accuracy and with a rigorous budget of their uncertainty sources. In the present paper we describe an accurate and traceable approach to determine the stopping cross sections in pure elemental materials—aluminum and molybdenum—for protons in the energy range of 0.9-3.6 MeV by the transmission method. The main sources of uncertainties here considered are (i) (random) the uncertainty in the peak positions and in the Gaussian fits and (ii) (systematic) the presence of thickness nonuniformity (a special procedure has been developed to correct it as far as possible). The accuracy in the final stopping cross section is 0.63 % (0.32 % random and 0.54 % systematic) for Al and 1.5 % (0.44 % random and 1.4 % systematic) for Mo, both mainly limited by the quality and homogeneity of the foils. For Al, this high accuracy represents an improvement compared to previous publications and serves as a benchmark for our procedure. For Mo, even though the uncertainty is somewhat higher, our results will help in improving the few data currently available in the energy range here considered. The data were also compared to the most commonly employed theoretical models (srim 1985, srim 2013, pstar, and casp 5.2) and Monte Carlo codes (geant 3 and geant 4). The experimental results are electronically available as supplemental material.

  19. 22 CFR 9a.6 - Marking.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Marking. 9a.6 Section 9a.6 Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS APPLICABLE TO CERTAIN INTERNATIONAL ENERGY PROGRAMS; RELATED MATERIAL § 9a.6 Marking. (a) The provisions of 22 CFR 9.15 through 9.19 shall govern the marking of information or...

  20. [Study on the Preparation of Ba3Si6O9N4 : Eu(2+) Phosphor and the Characterization of Their Luminescence Properties].

    PubMed

    Pan, Hua-yan; Wang, Le; Luo, Dong; Li, Yang-hui; Zhang, Hong; Shen, Ye

    2016-03-01

    Ba3Si6O9N4 : Eu(2+) phosphors were synthesized by two-step synthesis processes based on high temperature solid phase using BaSiO3 as a precursor. The influence mechanism of the Eu(2+) doping concentration to the luminescence properties of Ba3Si6O9N4 : Eu(2+) phosphors were mainly investigated. This paper made a comparison between the luminescence properties of Ba3Si6ON4 : Eu(2+) phosphors prepared by two-step processes and solid- state reaction method. The results showed that the Ba3Si6O9N4 : Eu(3+) phosphors synthesized by two-step processes had higher purity and higher crystallinity. There exists concentration quenching in Ba3Si6O9N4 : Eu(2+) phosphors for both two-step processes and solid-state reaction when the doping concentration x is more than 9%. Both the concentration quenching mechanism of Ba3 Si 09 N4 : EuI+ phosphor prepared by solid-state reaction and two-step processes is electric dipole-dipole interaction. The emission peak of Ba3Si6O9N4 : Eu(2+) phosphors (peak 489 nm) prepared by two-step processes had a blue shift compared to the emission peak of Ba3Si6O9N4 : Eu2+ phosphors (peak 512nm) prepared by solid-state reaction. The emission peak of Ba3Si6O9N4 : Eu2+ phosphors prepared by two-step processes relatively close to the theoretical value (480 nm). The spectrum analysis result showed that the element component of Ba3Si6O3N4 : Eu2+ phosphors prepared by two-step processes was closer to the theoretical value, it means that the two-step processes can effectively reduce the lattice defects. The Ba3Si6O9N4 : Eu(2+) phosphors synthesized by two-step processes had better thermal stability, which demonstrates to be a highly promising phosphor for white-LED applications. PMID:27400500

  1. Laser spectroscopy of the [17.9]4 - X3Φ4 and [15.6]Ω - X3Φ4 transitions of iridium monochloride (IrCl)

    NASA Astrophysics Data System (ADS)

    Adam, A. G.; Foran, S.; Linton, C.

    2016-01-01

    Laser Induced Fluorescence (LIF) spectra of two electronic transitions, [17.9]4 - X3Φ4 and [15.6]Ω - X3Φ4, of IrCl have been obtained in a laser-ablation molecular beam source, at low resolution using a pulsed dye laser, and at high resolution using a single mode ring dye laser. The 193Ir35Cl-193Ir37Cl isotope shifts of the band heads in the low resolution spectra established the vibrational assignment of the 0-0, 1-0, 2-0 and 0-1 bands of the [17.9]4 - X3Φ4 transition and the 0-0 and 1-0 bands of the [15.6]Ω - X3Φ4 transition. High resolution spectra (linewidth ∼ 0.006 cm-1 FWHM) were obtained for the 0-0, 1-0 and 2-0 bands of the more intense [17.9]4 - X3Φ4 transition. Rotational structure in the three bands of both 193Ir35Cl and 191Ir35Cl isotopologues was resolved and analyzed. The higher J rotational lines are observed to split into closely spaced doublets resulting from quadrupole hyperfine structure caused by the I = 3/2 nuclear spin in 191Ir and 193Ir. Examination of the spectra shows that the doublet separation of ∼0.008 cm-1 is similar to that observed in IrF (Linton et al., 2011) indicating that the quadrupole parameters, eQq0, are similar in IrF and IrCl.

  2. New (RS)-benzoxazepin-purines with antitumour activity: The chiral switch from (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine.

    PubMed

    López-Cara, Luisa C; Conejo-García, Ana; Marchal, Juan A; Macchione, Giuseppe; Cruz-López, Olga; Boulaiz, Houria; García, María A; Rodríguez-Serrano, Fernando; Ramírez, Alberto; Cativiela, Carlos; Jiménez, Ana I; García-Ruiz, Juan M; Choquesillo-Lazarte, Duane; Aránega, Antonia; Campos, Joaquín M

    2011-01-01

    Completing an SAR study, a series of (RS)-6-substituted-7- or 9-(1,2,3,5-tetrahydro-4,1-benzoxazepine-3-yl)-7H or 9H-purines has been prepared under microwave-assisted conditions. Their antiproliferative activities on MCF-7 and MDA-MB-231 cancerous cell lines are presented, being the majority of the IC(50) values below 1μM. The most active compound (RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine (14) presents an IC(50) of 0.166μM against the human cancerous cell line MDA-MB-231. Compound 14 was the most selective against the human breast adenocarcinoma MCF-7 and MDA-MB-231 cancer cell lines (Therapeutic Indexes, TIs=5.1 and 11.0, respectively) in relation to the normal one MCF-10A. (RS)-14 was resolved into its enantiomers. Both enantiomers are equally potent, but more potent than the corresponding racemic mixture. (R)-14 induces apoptosis against MCF-7 up to 52.50% of cell population after 48h, being more potent than the clinical-used drug paclitaxel (43%). (RS)-14 induces no acute toxicity in mice after two weeks of treatment. PMID:21126804

  3. Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells.

    PubMed

    Dardalhon, Valerie; Anderson, Ana C; Karman, Jozsef; Apetoh, Lionel; Chandwaskar, Rucha; Lee, David H; Cornejo, Melanie; Nishi, Nozomu; Yamauchi, Akira; Quintana, Francisco J; Sobel, Raymond A; Hirashima, Mitsuomi; Kuchroo, Vijay K

    2010-08-01

    IFN-gamma plays a central role in antitumor immunity. T cell Ig and mucin domain (Tim-3) is expressed on IFN-gamma-producing Th1 cells; on interaction with its ligand, galectin-9, Th1 immunity is terminated. In this study, we show that transgenic overexpression of Tim-3 on T cells results in an increase in CD11b(+)Ly-6G(+) cells and inhibition of immune responses. Molecular characterization of CD11b(+)Ly-6G(+) cells reveals a phenotype consistent with granulocytic myeloid-derived suppressor cells. Accordingly, we find that modulation of the Tim-3/galectin-9 (Gal-9) pathway impacts on tumor growth. Similarly, overexpression of Tim-3 ligand, Gal-9, results in an increase in CD11b(+)Ly-6G(+) cells and inhibition of immune responses. Loss of Tim-3 restores normal levels of CD11b(+)Ly-6G(+) cells and normal immune responses in Gal-9 transgenic mice. Our data uncover a novel mechanism by which the Tim-3/Gal-9 pathway regulates immune responses and identifies this pathway as a therapeutic target in diseases where myeloid-derived suppressor cells are disadvantageous. PMID:20574007

  4. Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

    PubMed Central

    2015-01-01

    (−)-P7C3-S243 is a neuroprotective aminopropyl carbazole with improved druglike properties compared with previously reported compounds in the P7C3 class. It protects developing neurons in a mouse model of hippocampal neurogenesis and protects mature neurons within the substantia nigra in a mouse model of Parkinson’s disease. A short, enantioselective synthesis provides the neuroprotective agent in optically pure form. It is nontoxic, orally bioavailable, metabolically stable, and able to cross the blood–brain barrier. As such, it represents a valuable lead compound for the development of drugs to treat neurodegenerative diseases and traumatic brain injury. PMID:24697290

  5. Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells.

    PubMed

    Kaliman, P; Canicio, J; Shepherd, P R; Beeton, C A; Testar, X; Palacín, M; Zorzano, A

    1998-01-01

    Phosphatidylinositol 3 (PI 3)-kinases are potently inhibited by two structurally unrelated membrane-permeant reagents: wortmannin and LY294002. By using these two inhibitors we first suggested the involvement of a PI 3-kinase activity in muscle cell differentiation. However, several reports have described that these compounds are not as selective for PI 3-kinase activity as assumed. Here we show that LY294002 blocks the myogenic pathway elicited by insulin-like growth factors (IGFs), and we confirm the specific involvement of PI 3-kinase in IGF-induced myogenesis by overexpressing in L6E9 myoblasts a dominant negative p85 PI 3-kinase-regulatory subunit (L6E9-delta p85). IGF-I, des(1-3)IGF-I, or IGF-II induced L6E9 skeletal muscle cell differentiation as measured by myotube formation, myogenin gene expression, and GLUT4 glucose carrier induction. The addition of LY294002 to the differentiation medium totally inhibited these IGF-induced myogenic events without altering the expression of a non-muscle-specific protein, beta1-integrin. Independent clones of L6E9 myoblasts expressing a dominant negative mutant of the p85-regulatory subunit (delta p85) showed markedly impaired glucose transport activity and formation of p85/p110 complexes in response to insulin, consistent with the inhibition of PI 3-kinase activity. IGF-induced myogenic parameters in L6E9-delta p85 cells, ie. cell fusion and myogenin gene and GLUT4 expression, were severely impaired compared with parental cells or L6E9 cells expressing wild-type p85. In all, data presented here indicate that PI 3-kinase is essential for IGF-induced muscle differentiation and that the specific PI 3-kinase subclass involved in myogenesis is the heterodimeric p85-p110 enzyme. PMID:9440811

  6. Epigenetic response to environmental stress: Assembly of BRG1-G9a/GLP-DNMT3 repressive chromatin complex on Myh6 promoter in pathologically stressed hearts.

    PubMed

    Han, Pei; Li, Wei; Yang, Jin; Shang, Ching; Lin, Chiou-Hong; Cheng, Wei; Hang, Calvin T; Cheng, Hsiu-Ling; Chen, Chen-Hao; Wong, Johnson; Xiong, Yiqin; Zhao, Mingming; Drakos, Stavros G; Ghetti, Andrea; Li, Dean Y; Bernstein, Daniel; Chen, Huei-Sheng Vincent; Quertermous, Thomas; Chang, Ching-Pin

    2016-07-01

    Chromatin structure is determined by nucleosome positioning, histone modifications, and DNA methylation. How chromatin modifications are coordinately altered under pathological conditions remains elusive. Here we describe a stress-activated mechanism of concerted chromatin modification in the heart. In mice, pathological stress activates cardiomyocytes to express Brg1 (nucleosome-remodeling factor), G9a/Glp (histone methyltransferase), and Dnmt3 (DNA methyltransferase). Once activated, Brg1 recruits G9a and then Dnmt3 to sequentially assemble repressive chromatin-marked by H3K9 and CpG methylation-on a key molecular motor gene (Myh6), thereby silencing Myh6 and impairing cardiac contraction. Disruption of Brg1, G9a or Dnmt3 erases repressive chromatin marks and de-represses Myh6, reducing stress-induced cardiac dysfunction. In human hypertrophic hearts, BRG1-G9a/GLP-DNMT3 complex is also activated; its level correlates with H3K9/CpG methylation, Myh6 repression, and cardiomyopathy. Our studies demonstrate a new mechanism of chromatin assembly in stressed hearts and novel therapeutic targets for restoring Myh6 and ventricular function. The stress-induced Brg1-G9a-Dnmt3 interactions and sequence of repressive chromatin assembly on Myh6 illustrates a molecular mechanism by which the heart epigenetically responds to environmental signals. This article is part of a Special Issue entitled: Cardiomyocyte Biology: Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel. PMID:26952936

  7. Intramolecular d10-d10 interactions in a Ni6C(CO)9(AuPPh3)4 bimetallic nickel-gold carbide carbonyl cluster.

    PubMed

    Ciabatti, Iacopo; Femoni, Cristina; Iapalucci, Maria Carmela; Ienco, Andrea; Longoni, Giuliano; Manca, Gabriele; Zacchini, Stefano

    2013-09-16

    The Ni6C(CO)9(AuPPh3)4 bimetallic carbide carbonyl cluster was obtained from the reaction of [Ni9C(CO)17](2-) with Au(PPh3)Cl. It contains a rare carbon-centered (distorted) Ni6C octahedral core decorated by four Au(PPh3) fragments. These are μ3-bonded to four contiguous Ni3-triangular faces and display weak intramolecular Au···Au d(10)-d(10) interactions. The cluster has been characterized in the solid state on two different solvato crystals, i.e., Ni6C(CO)9(AuPPh3)4·THF and Ni6C(CO)9(AuPPh3)4·THF·0.5C6H14. The two solvates show some interesting differences concerning the weak Au···Au contacts. Density functional theory calculations have demonstrated that the presence of the two isomers is related to solid-state packing effects and not to the existence of two double minima in the potential energy surface. This, in turn, confirms that Au···Au d(10)-d(10) interactions are rather soft and thus influenced also by weak van der Waals forces because of the interaction of the cluster with the cocrystallized solvent molecules. PMID:24004143

  8. Variations of lipid profile in animals caused by adenosine analogs: N6 (amido-3-propyl) adenosine hydrochloride and (carboxamido-3-propylamino)-6-(triproprionyl) 2',3',5'beta (D-ribosyl)-9-purine.

    PubMed

    Laborit, G; Hasni, H; Baron, C; Pierrefiche, G; Laborit, H

    1992-03-01

    N6-substituted adenosine analogues are powerful inhibitors of lipolysis in the adipose tissues of animals and humans, because of their agonist effect on A1 purine receptors. Using a model of hypertriglyceridemia provoked by intravenous injection of Triton WR 1339, we observed that Agr 529 [N6(amido-3-propyl)adenosine hydrochloride] at 2 mg.kg-1 intravenous in rabbits, and intraperitoneally and orally in rats led to a return of the levels of circulating triglycerides to normal values. In addition, Agr 529 and its prodrug, Agr 540 [(carboxamido-3-propylamino)-6-(triproprionyl)2', 3',5'beta(D-ribosyl)-9-purine] administered to rats at 3 and 30 mg.kg-1, respectively, returned plasma triglyceride concentrations to normal levels. Intravenous administration of Agr 529 to normal rats led to decreased concentrations of plasma fatty acids, phospholipids, triglycerides and total cholesterol as a function of dose. The decrease began at 0.1 mg.kg-1 and was highly significant at 3 mg.kg-1. In the same conditions, the intraperitoneal administration of Agr 529 caused a dose-dependent hypolipemia. There was no apparent effect on cholesterol and on the triglycerides of high density lipoproteins. A kinetic study showed that the antilipemic effect of Agr 529 intravenously injected at 3 mg.kg-1 began 30 minutes after the injection with a maximum effect at 2 hours. The effect persisted up to 8 hours after injection. The present results show that the administration of Agr 529 and Agr 540 to normal animals causes hypolipemia (decrease in fatty acids, phospholipids, triglycerides and cholesterol) and restores induced hypertriglyceridemia. These effects may be attributed to an interaction of the molecules with A1 purinergic receptors of adipose tissue. PMID:1509199

  9. Effects of distortion of the intercluster motion in {sup 2}H, {sup 3}He, {sup 3}H, {sup 6}Li, and {sup 9}Be on Trojan horse applications

    SciTech Connect

    Pizzone, R. G.; Spitaleri, C.; La Cognata, M.; Lamia, L.; Romano, S.; Mukhamedzhanov, A. M.; Blokhintsev, L. D.; Bertulani, C. A.; Irgaziev, B. F.

    2009-08-15

    Deuteron induced quasifree scattering and reactions have been extensively investigated in the past few decades as well as {sup 6}Li, {sup 3}H, {sup 3}He, and {sup 9}Be induced reactions. This was done not only for the investigation of nuclear structure and reaction mechanisms but also for important astrophysical applications (Trojan horse method). In particular the widths of the spectator momentum distributions in several nuclei, which have been used as Trojan horses, have been obtained as a function of the transferred momentum. Applications of Trojan horse method will also be discussed because the momentum distribution of the spectator particle inside the nucleus is a important input for this method. This gives hints on distortion effects at low energies important for nuclear astrophysics.

  10. 22 CFR 9a.6 - Marking.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... PROGRAMS; RELATED MATERIAL § 9a.6 Marking. (a) The provisions of 22 CFR 9.15 through 9.19 shall govern the... following stamp shall be used as appropriate: (Top Secret, Secret or Confidential) Classified by:...

  11. Effect of cation substitution on structural transition: synthesis, characterization and theoretical studies of NaCa4B3O9, NaCaBO3, NaSrBO3 and Li4CaB2O6.

    PubMed

    Yang, Yun; Su, Xin; Pan, Shilie; Yang, Zhihua

    2015-10-21

    Single crystals of NaCa4B3O9, NaCaBO3, NaSrBO3 and Li4CaB2O6 have been successfully synthesized through conventional high-temperature solid-state reactions. They are structurally characterized by single crystal X-ray diffraction and exhibit three-dimensional crystal structures consisting of isolated planar BO3 as fundamental building blocks. Interestingly, for the centrosymmetric crystal structure of NaCaBO3 (Na3Ca3B3O9), as 2/3 of the Na(+) ions are substituted by Ca(2+) ions, NaCa4B3O9 is obtained and crystallizes in the noncentrosymmetric space group Ama2 (crystal class mm2). A second harmonic generation (SHG) test of the title compound by the Kurtz-Perry method shows that NaCa4B3O9 can be phase matchable with an effective SHG coefficient approximately one-half that of KH2PO4 (KDP). Studies of their optical properties as well as band structure calculations based on density functional theory methods have been also performed. NaCa4B3O9 possesses a moderate birefringence of about 0.05 at 1064 nm. To explain the difference in optical nonlinearity we compared the electronic structures of NaCa4B3O9, KCa4B3O9 and KSr4B3O9 crystals, in particular at the bottom of the conduction band (CB) and the top of the valence band (VB), since they are known to play a primary role in SHG. These electronic structures are responsible for the optical-nonlinearity of NaCa4B3O9, KCa4B3O9 and KSr4B3O9 crystals. PMID:26387438

  12. Fructose-1,6-bisphosphatase: Genetic and physical mapping to human chromosome 9q22.3 and evaluation in non-insulin-dependent diabetes mellitus

    SciTech Connect

    Rothschild, C.B.; Akots, G.; Roh, B.

    1995-09-01

    PCR primers specific to the human liver fructose-1,6-bisphosphatase (FBP) gene were designed and used to isolate a cosmid clone. Physical mapping of the FBP cosmid by FISH, and genetic mapping of an associated GA repeat polymorphism (PIC = 0.35), located the liver FBP gene to chromosome 9q22.3 with no recombination between FBP and the index markers D9S196 (Z{sub max} = 13.2), D9S280 (Z{sub max} = 11.7), D9S287 (Z{sub max} = 15.6), and D9S176 (Z{sub max} = 14.4). Amplification using FBP exon-specific primers with a YAC contig from this region of chromosome 9 further refined the placement of FBP genomic sequences to an approximately 1.7-cM region flanked by D9S280 and D9S287, near the gene for Fanconi anemia group C. Precise localization of the FBP gene enabled evaluation of FBP as a candidate gene for maturity-onset diabetes of the young (MODY) and non-insulin-dependent diabetes (NIDDM) in both Caucasian and African-American families, using the highly informative markers D9S287 and D9S176. Although FBP is a rate-limiting enzyme in gluconeogenesis, using both parametric and nonparametric analysis there was no evidence for linkage of FBP to diabetes in these families. 30 refs., 4 figs., 2 tabs.

  13. Mean Length of Utterance Levels in 6-month Intervals for Children 3 to 9 Years with and without Language Impairments

    PubMed Central

    Rice, Mabel L.; Smolik, Filip; Perpich, Denise; Thompson, Travis; Rytting, Nathan; Blossom, Megan

    2009-01-01

    Purpose The mean length of children’s utterances is a valuable estimate of their early language acquisition. The available normative data lacks documentation of language and nonverbal intelligence levels of the samples. This study reports age-referenced MLU data from children with specific language impairment and children without language impairments. Method 306 child participants were drawn from a data archive, ages 2;69;0 years, 170 with SLI and 136 control children. 1564 spontaneous language samples were collected, transcribed and analyzed for sample size and MLU in words and morphemes. Means, standard deviations, and effect sizes for group differences are reported for MLUs, along with concurrent language and nonverbal intelligence assessments, per 6-month intervals. Results The results document an age progression in MLU words and morphemes, and a persistent lower level of performance for children with SLI. Conclusions The results support the reliability and validity of MLU as an index of normative language acquisition and a marker of language impairment. The findings can be used for clinical benchmarking of deficits and language intervention outcomes, as well as comparisons across research samples. PMID:20360460

  14. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 1 2011-01-01 2011-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  15. 22 CFR 19.6-9 - Limitations.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Limitations. 19.6-9 Section 19.6-9 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR SPOUSES AND FORMER SPOUSES OF PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-9 Limitations. (a) Retirement benefits are...

  16. 22 CFR 19.6-9 - Limitations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Limitations. 19.6-9 Section 19.6-9 Foreign Relations DEPARTMENT OF STATE PERSONNEL BENEFITS FOR SPOUSES AND FORMER SPOUSES OF PARTICIPANTS IN THE FOREIGN SERVICE RETIREMENT AND DISABILITY SYSTEM § 19.6-9 Limitations. (a) Retirement benefits are...

  17. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.6 Communications. Except as otherwise indicated, communications relating to this part shall be addressed to the Freedom of Information Act and Privacy Act Officer, may be sent...

  18. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  19. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 1 2012-01-01 2012-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  20. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 1 2013-01-01 2013-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  1. 7 CFR 6.9 - Information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 1 2014-01-01 2014-01-01 false Information. 6.9 Section 6.9 Agriculture Office of the Secretary of Agriculture IMPORT QUOTAS AND FEES General Provisions § 6.9 Information. Persons desiring information from the Department of Agriculture regarding section 22 or section 8(a), or any action...

  2. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 1 2012-01-01 2012-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.6 Communications. Except as otherwise indicated, communications relating to this part shall be addressed to the Freedom of Information Act and Privacy Act Officer, may be sent...

  3. 10 CFR 9.6 - Communications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 10 Energy 1 2013-01-01 2013-01-01 false Communications. 9.6 Section 9.6 Energy NUCLEAR REGULATORY COMMISSION PUBLIC RECORDS § 9.6 Communications. Except as otherwise indicated, communications relating to this part shall be addressed to the Freedom of Information Act and Privacy Act Officer, may be sent...

  4. Tunable full-color emitting BaMg2Al6Si9O30:Eu2+, Tb3+, Mn2+ phosphors based on energy transfer.

    PubMed

    Lü, Wei; Hao, Zhendong; Zhang, Xia; Luo, Yongshi; Wang, Xiaojun; Zhang, Jiahua

    2011-08-15

    A series of single-phase full-color emitting BaMg(2)Al(6)Si(9)O(30):Eu(2+), Tb(3+), Mn(2+) phosphors has been synthesized by solid-state reaction. Energy transfer from Eu(2+) to Tb(3+) and Eu(2+) to Mn(2+) in BaMg(2)Al(6)Si(9)O(30) host matrix is studied by luminescence spectra and energy-transfer efficiency and lifetimes. The wavelength-tunable white light can be realized by coupling the emission bands centered at 450, 542, and 610 nm ascribed to the contribution from Eu(2+) and Tb(3+) and Mn(2+), respectively. By properly tuning the relative composition of Tb(3+)/Mn(2+), chromaticity coordinates of (0.31, 0.30), high color rendering index R(a) = 90, and correlated color temperature (CCT) = 5374 K can be achieved upon excitation of UV light. Thermal quenching properties reveal that BaMg(2)Al(6)Si(9)O(30): Eu(2+), Tb(3+), Mn(2+) exhibits excellent characteristics even better than that of YAG:Ce. Our results indicate our white BaMg(2)Al(6)Si(9)O(30):Eu(2+), Tb(3+), Mn(2+) can serve as a key material for phosphor-converted light-emitting diode and fluorescent lamps. PMID:21766885

  5. Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin.

    PubMed Central

    Kaliman, P; Viñals, F; Testar, X; Palacín, M; Zorzano, A

    1995-01-01

    In this study we have used wortmannin, a highly specific inhibitor of phosphatidylinositol (PI) 3-kinase, to assess the role of this enzyme on GLUT1 glucose carrier distribution and glucose transport activity in myoblasts from two skeletal-muscle cell lines, L6E9 and Sol8. As detected in L6E9 cells, myoblasts exhibited basal and insulin-stimulated PI 3-kinase activities. Incubation of intact myoblasts with wortmannin resulted in a marked inhibition of both basal and insulin-stimulated PI 3-kinase activities. L6E9 and Sol8 myoblasts showed basal and insulin-stimulated glucose transport activities, both of them inhibited by wortmannin in a dose-dependent manner (IC50 approximately 10-20 nM). Concomitantly, immunofluorescence analysis revealed that 1 h treatment with wortmannin led to a dramatic intracellular accumulation of GLUT1 carriers (the main glucose transporter expressed in L6E9 and Sol8 myoblasts) in both cell systems. The effect of wortmannin on GLUT1 cellular redistribution was independent of the presence of insulin. The cellular distribution of two structural plasma-membrane components such as beta 1-integrin or the alpha 1 subunit of the Na(+)-K(+)-ATPase were unaffected by wortmannin in both the absence and the presence of insulin. As a whole, our results indicate that PI 3-kinase is necessary to basal and insulin-stimulated glucose transport in L6E9 and Sol8 myoblasts. Moreover, immunofluorescence assays suggest that in both cellular models there is a constitutive GLUT 1 trafficking pathway (independent of insulin) that involves PI 3-kinase and which, when blocked, locks GLUT1 in a perinuclear compartment. Images Figure 1 Figure 3 Figure 4 Figure 5 Figure 6 PMID:8526858

  6. Sr{sub 9}Ni{sub 6.64}O{sub 21}: A new member (n = 2) of the perovskite-related A{sub 3n+3}A{sub n}{prime}B{sub 3+n}O{sub 9+6n} family

    SciTech Connect

    Campa, J.; Gutierrez-Puebla, E.; Monge, A.

    1996-10-01

    Crystals of a new phase Sr{sub 9}Ni{sub 6.64}O{sub 21} were grown. This compound in the n = 2 member of the A{sub 3n+3}A{sub n}{prime}B{sub n+3}O{sub 6n+9} series. The composition and the crystal structure have been established form X-ray single crystal diffraction data. The structure contains face-shared chains of NiO{sub 6} polyhedra parallel to the c axis and is related with hexagonal 2H polytype perovskite. Sr{sub 9}Ni{sub 6.64}O{sub 21} crystallizes in the space group R3c (No. 167) with a = 9.467(2) {angstrom}, c = 35.87(5) {angstrom}, V = 2784.(4) {angstrom}{sup 3}, and Z = 6. A comparison is made between the structure of the title compound and the other members of the series.

  7. Catalytic Cage Formation via Controlled Dimerization of Norbornadienes: An Entry to Functionalized HCTDs (Heptacyclo[6.6.0.0(2,6).0(3,13).0(4,11).0(5,9).0(10,14)]tetradecanes).

    PubMed

    Lim, Hee Nam; Dong, Guangbin

    2016-03-01

    A general and practical catalytic method has been developed for the rapid synthesis of HCTD (heptacyclo[6.6.0.0(2,6).0(3,13).0(4,11).0(5,9).0(10,14)]tetradecanes) and various new 7,12-disubstituted HCTDs from norbornadienes. Compared to the known approaches, this new protocol avoids stoichiometric metals, utilizes commercially available reagents as catalysts, and affords higher yields and significantly improved selectivity. In addition, quadracyclane was discovered for the first time to undergo a similar endo,cis,endo cycloaddition to give HCTD in a good yield. Derivatization of HCTDs led to efficient preparation of a range of novel homo- and heterobifunctional scaffolds that hold potentials for biological and material applications. PMID:26862783

  8. 17 CFR 240.3b-11 - Definitions relating to limited partnership roll-up transactions for purposes of sections 6(b)(9...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... limited partnership roll-up transactions for purposes of sections 6(b)(9), 14(h) and 15A(b)(12)-(13). 240... Securities Exchange Act of 1934 Definitions § 240.3b-11 Definitions relating to limited partnership roll-up... limited partnership roll-up transaction does not include a transaction involving only entities that...

  9. The Role of Morphology and Short Vowelization in Reading Arabic among Normal and Dyslexic Readers in Grades 3, 6, 9, and 12

    ERIC Educational Resources Information Center

    Abu-Rabia, Salim

    2007-01-01

    This study was an investigation of several Arabic reading measures among dyslexics and normal Arabic readers across different ages (grades 3, 6, 9, and 12): the role of morphology, short vowelization (phonological and syntactic skills), spelling, reading isolated words, and reading comprehension. The results of the one-way ANOVAs indicated clear…

  10. Disruption of GLUT1 glucose carrier trafficking in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin.

    PubMed

    Kaliman, P; Viñals, F; Testar, X; Palacín, M; Zorzano, A

    1995-12-01

    In this study we have used wortmannin, a highly specific inhibitor of phosphatidylinositol (PI) 3-kinase, to assess the role of this enzyme on GLUT1 glucose carrier distribution and glucose transport activity in myoblasts from two skeletal-muscle cell lines, L6E9 and Sol8. As detected in L6E9 cells, myoblasts exhibited basal and insulin-stimulated PI 3-kinase activities. Incubation of intact myoblasts with wortmannin resulted in a marked inhibition of both basal and insulin-stimulated PI 3-kinase activities. L6E9 and Sol8 myoblasts showed basal and insulin-stimulated glucose transport activities, both of them inhibited by wortmannin in a dose-dependent manner (IC50 approximately 10-20 nM). Concomitantly, immunofluorescence analysis revealed that 1 h treatment with wortmannin led to a dramatic intracellular accumulation of GLUT1 carriers (the main glucose transporter expressed in L6E9 and Sol8 myoblasts) in both cell systems. The effect of wortmannin on GLUT1 cellular redistribution was independent of the presence of insulin. The cellular distribution of two structural plasma-membrane components such as beta 1-integrin or the alpha 1 subunit of the Na(+)-K(+)-ATPase were unaffected by wortmannin in both the absence and the presence of insulin. As a whole, our results indicate that PI 3-kinase is necessary to basal and insulin-stimulated glucose transport in L6E9 and Sol8 myoblasts. Moreover, immunofluorescence assays suggest that in both cellular models there is a constitutive GLUT 1 trafficking pathway (independent of insulin) that involves PI 3-kinase and which, when blocked, locks GLUT1 in a perinuclear compartment. PMID:8526858

  11. Cs3Zn6B9O21: a chemically benign member of the KBBF family exhibiting the largest second harmonic generation response.

    PubMed

    Yu, Hongwei; Wu, Hongping; Pan, Shilie; Yang, Zhihua; Hou, Xueling; Su, Xin; Jing, Qun; Poeppelmeier, Kenneth R; Rondinelli, James M

    2014-01-29

    Nonlinear optical (NLO) crystals are essential materials for generation of coherent UV light in solid state lasers. KBBF is the only material that can achieve coherent light below 200 nm by direct second harmonic generation (SHG). However, its strong layer habits and the high toxicity of the beryllium oxide powders required for synthesis limit its application. By substituting Be with Zn and connecting adjacent [Zn2BO3O2]∞ layers by B3O6 groups, a new UV nonlinear optical material, Cs3Zn6B9O21, was synthesized. It overcomes the processing limitations of KBBF and exhibits the largest SHG response in the KBBF family. PMID:24393068

  12. Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins.

    PubMed

    Girennavar, B; Jayaprakasha, G K; Patil, B S

    2007-10-01

    The cytochrome P450 enzyme family is the most abundant and responsible for the metabolism of more than 60% of currently marketed drugs and is considered central in many clinically important drug interactions. Seven different grapefruit and pummelo juices as well as 5 furocoumarins isolated from grapefruit juice were evaluated at different concentration on cytochrome P450 3A4 (CYP3A4), cytochrome P450 2C9 (CYP2C9), and cytochrome P450 2D6 (CYP2D6) isoenzyme activity. Grapefruit and pummelo juices were found to be potent inhibitors of cytochrome CYP3A4 and CYP2C9 isoenzymes at 25% concentration, while CYP2D6 is inhibited significantly low at all the tested concentration of juices (P < 0.05). Among the 5 furocoumarins tested, the inhibitory potency was in the order of paradisin A > dihydroxybergamottin > bergamottin > bergaptol > geranylcoumarin at 0.1 microM to 0.1 mM concentrations. The IC(50) value was lowest for paradisin A for CYP3A4 with 0.11 microM followed by DHB for CYP2C9 with 1.58 microM. PMID:17995595

  13. Hydrothermal synthesis and characterization of the first mixed alkali borate-nitrate K{sub 3}Na[B{sub 6}O{sub 9}(OH){sub 3}]NO{sub 3}

    SciTech Connect

    Ortner, Teresa S.; Wurst, Klaus; Perfler, Lukas; Tribus, Martina; Huppertz, Hubert

    2015-01-15

    The first mixed alkali borate-nitrate K{sub 3}Na[B{sub 6}O{sub 9}(OH){sub 3}]NO{sub 3} was synthesized under hydrothermal conditions from Na{sub 2}B{sub 4}O{sub 7}·10H{sub 2}O and K{sub 2}B{sub 4}O{sub 7}·4H{sub 2}O using KNO{sub 3} as a nitrate source. The compound crystallizes in the space group Pnnm (no. 58) with the lattice parameters a=1320.8(3), b=910.7(2), and c=1232.5(3) pm (Z=4). Isolated Sechserrings formed by BO{sub 4} and BO{sub 3} groups are linked through hydrogen bridges to form a three-dimensional network. - Graphical abstract: The first mixed alkali borate-nitrate K{sub 3}Na[B{sub 6}O{sub 9}(OH){sub 3}]NO{sub 3} was synthesized under hydrothermal conditions from Na{sub 2}B{sub 4}O{sub 7}·10H{sub 2}O and K{sub 2}B{sub 4}O{sub 7}·4H{sub 2}O using KNO{sub 3} as a nitrate source. - Highlights: • The first mixed alkali borate-nitrate K{sub 3}Na[B{sub 6}O{sub 9}(OH){sub 3}]NO{sub 3} is reported. • Hydrothermal conditions (240 °C, 3d) were used for the synthesis of K{sub 3}Na[B{sub 6}O{sub 9}(OH){sub 3}]NO{sub 3}. • Borate Sechserrings are interconnected through hydrogen-bonding.

  14. 6 CFR 1001.9 - Business information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Business information. 1001.9 Section 1001.9... THE FREEDOM OF INFORMATION ACT § 1001.9 Business information. (a) Designation of confidential business information. In the event a FOIA request is made for confidential business information previously submitted...

  15. 22 CFR 9a.6 - Marking.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... PROGRAMS; RELATED MATERIAL § 9a.6 Marking. (a) The provisions of 22 CFR 9.15 through 9.19 shall govern the... following stamp shall be used as appropriate: (Top Secret, Secret or Confidential) Classified by: Under Executive Order 11932 Exempt from General Declassification Schedule of E.O. 11652 Exemption Category...

  16. 22 CFR 9a.6 - Marking.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... PROGRAMS; RELATED MATERIAL § 9a.6 Marking. (a) The provisions of 22 CFR 9.15 through 9.19 shall govern the... following stamp shall be used as appropriate: (Top Secret, Secret or Confidential) Classified by: Under Executive Order 11932 Exempt from General Declassification Schedule of E.O. 11652 Exemption Category...

  17. 22 CFR 9a.6 - Marking.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... PROGRAMS; RELATED MATERIAL § 9a.6 Marking. (a) The provisions of 22 CFR 9.15 through 9.19 shall govern the... following stamp shall be used as appropriate: (Top Secret, Secret or Confidential) Classified by: Under Executive Order 11932 Exempt from General Declassification Schedule of E.O. 11652 Exemption Category...

  18. 6 CFR 21.9 - Compliance information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Compliance information. 21.9 Section 21.9... OF RACE, COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM THE DEPARTMENT OF HOMELAND SECURITY § 21.9 Compliance information. (a) Cooperation and...

  19. 6 CFR 21.9 - Compliance information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Compliance information. 21.9 Section 21.9... OF RACE, COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM THE DEPARTMENT OF HOMELAND SECURITY § 21.9 Compliance information. (a) Cooperation and...

  20. 6 CFR 21.9 - Compliance information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Compliance information. 21.9 Section 21.9... OF RACE, COLOR, OR NATIONAL ORIGIN IN PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE FROM THE DEPARTMENT OF HOMELAND SECURITY § 21.9 Compliance information. (a) Cooperation and...

  1. 31 CFR 9.6 - Confidential information.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... information obtained from a person and privileged, within the meaning of 5 U.S.C. 552 and 31 CFR part 1, will... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Confidential information. 9.6 Section... ON THE NATIONAL SECURITY § 9.6 Confidential information. Information submitted in confidence...

  2. The thermodynamic properties of 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. [Tetrahydropyrene and hexahydropyrene

    SciTech Connect

    Chirico, R.D.; Knipmeyer, S.E.; Nguyen, A.; Smith, N.K.; Steele, W.V.

    1992-12-01

    Measurements leading to the calculation of the ideal-gas thermodynamic properties are reported for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene. Experimental methods included combustion calorimetry, adiabatic heat-capacity calorimetry, vibrating-tube densitometry, comparative ebulliometry, inclined-piston gauge manometry, and differential-scanning calorimetry (d.s.c.). Critical properties were estimated for both materials based on the measurement results. Entropies, enthalpies, and Gibbs energies of formation were derived for the ideal gases for selected temperatures between 380 K and 700 K. The property-measurement results reported here for 4,5,9,10-tetrahydropyrene and 1,2,3,6,7,8-hexahydropyrene are the first for these important intermediates in the pyrene/H[sub 2] hydrogenation reaction network.

  3. High efficiency antireflection coating in MWIR region (3.6-4.9 μm) simultaneously effective for Germanium and Silicon optics

    NASA Astrophysics Data System (ADS)

    Bhatt, Meenakshi; Nautiyal, B. B.; Bandyopadhyay, P. K.

    2010-01-01

    Antireflection coatings have critical importance in thermal imaging system working in MWIR region (3-5 μm) since optics of high refractive index materials are used. Germanium (Ge) and Silicon (Si) optics are used extensively in the MWIR thermal systems. In this paper a study has been carried out on the design and fabrication of multi-substrate antireflection coating effective for Germanium and Silicon optics in MWIR (3.6-4.9 μm) region. The wave band 3.6-4.9 μm is chosen for the reported work because detector system used in MWIR region has a band selection filter effective in the same wavelength region and atmospheric transmission window in MWIR region is effective in 3-5 μm spectral band. Comprehensive search method was used to design the multilayer stack on the substrate. The coating materials used in the design were Germanium (Ge), Hafnium oxide (HfO 2) and Y-Ba-Fluoride (IR-F625). The fabrication of coating was made in a coating plant fitted with Cryo pump system and residual gas analyzer (RGA). The evaporation was carried out at high vacuum (2-6 × 10 -6 mbar) with the help of electron beam gun system and layer thicknesses were measured with crystal monitor. The result achieved for the antireflection coating was 98.5% average transmission in 3.6-4.9 μm band for Germanium and Silicon optics. This work will be helpful in reducing the plant operation time, material and power consumption, as two different kinds of optics are simultaneously coated in a single coating cycle.

  4. 9 CFR 91.6 - Goats.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... exported if it is a scrapie-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Goats. 91.6 Section 91.6 Animals...

  5. 9 CFR 91.6 - Goats.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... exported if it is a scrapie-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Goats. 91.6 Section 91.6 Animals...

  6. 9 CFR 91.6 - Goats.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... exported if it is a scrapie-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Goats. 91.6 Section 91.6 Animals...

  7. Transcriptional Regulation of CYP3A4/2B6/2C9 Mediated via Nuclear Receptor PXR by Helicid and Its Metabolites

    PubMed Central

    Chen, Qun; Xie, Hai-tang; Li, Yan; Wang, Guo; Xu, Zhe; Pu, Zhi-chen; Hu, Hua

    2015-01-01

    Objective. This study aims at establishing and validating an in vitro system to screen drug inducers of CYPs mediated via hPXR, as well as studying transcriptional regulation of CYPs mediated via hPXR by helicid and its two metabolites. Methods. Cloning the nuclear receptor hPXR and the promoters of CYP3A4, CYP2B6, CYP2C9, and inserting the trans-element to the upstream of firefly luciferase reporter gene of the pGL4.17 vectors, then cotransfecting the report vectors and hPXR expression plasmid to HepG2 cell line. After 24 hours, the transfected cells were treated with helicid (0.004, 0.04, and 0.4 μmol/L) and its metabolite I and metabolite II (0.0004, 0.004, and 0.04 μmol/L) for 48 h, while rifampin (10 μmol/L) was included as the positive control and 0.1% DMSO as the negative control group. Cells were lysized and luciferase activity was determined using a dual luciferase reporter assay kit. Results. Helicid and its metabolites did not significantly increase promoter activities of CYP3A4, CYP2B6, and CYP2C9 in HepG2 cells transfected with PXR expression plasmid (P > 0.05). Conclusion. PXR-expressed CYP3A4, CYP2B6, and CYP2C9 dual luciferase reporter gene platforms were successfully established, and helicid and its metabolites I, II do not significantly induce the transcription of CYP3A4, CYP2B6, and CYP2C9. PMID:25977700

  8. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  9. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  10. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  11. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9- bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9- bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  12. 40 CFR 721.9850 - 2,4,8,10-Tetraoxa-3,9-diphosphaspiro[5.5]undecane, 3,9-bis[2,4,6-tris(1,1-dimethylethyl)phenoxy]-.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false 2,4,8,10-Tetraoxa-3,9-diphosphaspiro undecane, 3,9-bis -. 721.9850 Section 721.9850 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances...

  13. Na3.88Mo15Se19: a novel ternary reduced molybdenum selenide containing Mo6 and Mo9 clusters

    PubMed Central

    Salloum, Diala; Gougeon, Patrick; Gall, Philippe

    2013-01-01

    The structure of tetrasodium penta­deca­molybdenum nona­deca­selenide, Na3.88Mo15Se19, is isotypic with the In3+xMo15Se19 compounds [Grüttner et al. (1979 ▶). Acta Cryst. B35, 285–292]. It is characterized by two cluster units, Mo6Sei 8Sea 6 and Mo9Sei 11Sea 6 (where i represents inner and a apical atoms), that are present in a 1:1 ratio. The cluster units are centered at Wyckoff positions 2b and 2c and have point-group symmetry -3 and -6, respectively. The clusters are inter­connected through additional Mo—Se bonds. In the title compound, the Na+ cations replace the trivalent as well as the monovalent indium atoms present in In3.9Mo15Se19. One Mo, one Se and one Na atom are situated on mirror planes, and two other Se atoms and one Na atom [occupancy 0.628 (14)] are situated on threefold rotation axes. The crystal studied was twinned by merohedry with refined components of 0.4216 (12) and 0.5784 (12). PMID:24098158

  14. 9 CFR 3.9 - Feeding.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.9 Feeding. (a) Dogs and cats must be fed at least once each day... condition. (b) Food receptacles must be used for dogs and cats, must be readily accessible to all dogs...

  15. 9 CFR 3.9 - Feeding.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.9 Feeding. (a) Dogs and cats must be fed at least once each day... condition. (b) Food receptacles must be used for dogs and cats, must be readily accessible to all dogs...

  16. 9 CFR 3.9 - Feeding.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.9 Feeding. (a) Dogs and cats must be fed at least once each day... condition. (b) Food receptacles must be used for dogs and cats, must be readily accessible to all dogs...

  17. 9 CFR 3.9 - Feeding.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.9 Feeding. (a) Dogs and cats must be fed at least once each day... condition. (b) Food receptacles must be used for dogs and cats, must be readily accessible to all dogs...

  18. 9 CFR 3.9 - Feeding.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.9 Feeding. (a) Dogs and cats must be fed at least once each day... condition. (b) Food receptacles must be used for dogs and cats, must be readily accessible to all dogs...

  19. Excellent stability of plasma-sprayed bioactive Ca 3ZrSi 2O 9 ceramic coating on Ti-6Al-4V

    NASA Astrophysics Data System (ADS)

    Liang, Ying; Xie, Youtao; Ji, Heng; Huang, Liping; Zheng, Xuebin

    2010-05-01

    In this work, novel zirconium incorporated Ca-Si based ceramic powder Ca 3ZrSi 2O 9 was synthesized. The aim of this study was to fabricate Ca 3ZrSi 2O 9 coating onto Ti-6Al-4V substrate using atmospheric plasma-spraying technology and to evaluate its potential applications in the fields of orthopedics and dentistry. The phase composition, surface morphologies of the coating were examined by XRD and SEM, which revealed that the Ca 3ZrSi 2O 9 coating was composed of grains around 100 nm and amorphous phases. The bonding strength between the coating and the substrate was 28 ± 4 MPa, which is higher than that of traditional HA coating. The dissolution rate of the coating was assessed by monitoring the ions release and mass loss after immersion in the Tris-HCl buffer solution. The in vitro bioactivity of the coating was determined by observing the formation of apatite on its surface in simulated body fluids. It was found that the Ca 3ZrSi 2O 9 coating possessed both excellent chemical stability and good apatite-formation ability, suggesting its potential use as bone implants.

  20. 9 CFR 149.6 - Slaughter facilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Slaughter facilities. 149.6 Section 149.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE LIVESTOCK IMPROVEMENT VOLUNTARY TRICHINAE CERTIFICATION PROGRAM § 149.6 Slaughter facilities. Only slaughter facilities that are under...

  1. 9 CFR 101.6 - Cell cultures.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Cell cultures. 101.6 Section 101.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS DEFINITIONS § 101.6 Cell cultures....

  2. 9 CFR 101.6 - Cell cultures.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Cell cultures. 101.6 Section 101.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS DEFINITIONS § 101.6 Cell cultures....

  3. 9 CFR 101.6 - Cell cultures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Cell cultures. 101.6 Section 101.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS DEFINITIONS § 101.6 Cell cultures....

  4. 9 CFR 149.6 - Slaughter facilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Slaughter facilities. 149.6 Section 149.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... period. 6 More information regarding sampling sizes may be obtained by writing to USDA, APHIS,...

  5. 9 CFR 149.6 - Slaughter facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Slaughter facilities. 149.6 Section 149.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... period. 6 More information regarding sampling sizes may be obtained by writing to USDA, APHIS,...

  6. 9 CFR 392.6 - Public display.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Public display. 392.6 Section 392.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.6 Public display. (a)...

  7. 9 CFR 392.6 - Public display.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Public display. 392.6 Section 392.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.6 Public display. (a)...

  8. 9 CFR 116.6 - Animal records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Animal records. 116.6 Section 116.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.6 Animal...

  9. 9 CFR 116.6 - Animal records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Animal records. 116.6 Section 116.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.6 Animal...

  10. 9 CFR 116.6 - Animal records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Animal records. 116.6 Section 116.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.6 Animal...

  11. 9 CFR 116.6 - Animal records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Animal records. 116.6 Section 116.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.6 Animal...

  12. 9 CFR 116.6 - Animal records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Animal records. 116.6 Section 116.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.6 Animal...

  13. 9 CFR 392.6 - Public display.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Public display. 392.6 Section 392.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.6 Public display. (a)...

  14. The short-circuit test results of 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer

    NASA Astrophysics Data System (ADS)

    Tomioka, A.; Otonari, T.; Ogata, T.; Iwakuma, M.; Okamoto, H.; Hayashi, H.; Iijima, Y.; Saito, T.; Gosho, Y.; Tanabe, K.; Izumi, T.; Shiohara, Y.

    2011-11-01

    We are developing an elemental technology for 66 kV/6.9 kV 20 MVA-class power transformer with YBCO conductors. The protection of short-circuit technology is one of the elemental technologies for HTS transformer. Since short-circuit current is much higher than critical current of YBCO tape, there is a possibility that superconducting characteristics may be damaged during short-circuit period. We made a conductor to compose the YBCO tape with copper tape. We manufactured 6.9 kV/2.3 kV 400 kVA-class YBCO model transformer using this conductor and performed short-circuit current test. The short-circuit current of primary winding was 346 A which was about six times larger than the rated current. The I-V characteristics of the winding did not change before and after the test. We may consider this conductor withstands short-circuit current.

  15. (3Z,6Z,9Z,12Z,15Z) -pentacosapentaene and (Z) -11-hexadecenyl acetate: sex attractant blend for Dioryctria amatella (Lepidoptera: Pyralidae).

    PubMed

    Miller, Daniel R; Millar, Jocelyn G; Mangini, Alex; Crowe, Christopher M; Grant, Gary G

    2010-08-01

    In 2006-2008, we tested (3Z,6Z,9Z,12Z,15Z)-pentacosapentaene (pentaene) with the pheromone components (Z)-11-hexadecenyl acetate (Z11-16:Ac) and (Z)-9-tetradecenyl acetate (Z9-14:Ac), as sex attractants for four sympatric species of coneworms, Dioryctria Zeller (Lepidoptera: Pyralidae) in slash (Pinus elliottii Engelm.) and loblolly pine (Pinus taeda L.) seed orchards in Georgia and Louisiana, respectively. The addition ofpentaene increased catches of male southern pine coneworm, Dioryctria amatella (Hulst), in wing traps baited with Z11-16:Ac, whereas catches of Dioryctria disclusa Heinrich in traps baited with Z9-14:Ac were unaffected by the addition of pentaene. The effect of pentaene on male Dioryctria merkeli Mutuura & Munroe was inconsistent. In 2006, pentaene seemed to inhibit attraction of D. merkeli to traps baited with Z9-14:Ac, whereas in a subsequent trial in 2008, moths were equally attracted to Z9-14:Ac with or without the pentaene. We caught too few Dioryctria clarioralis (Walker) in any experiment for meaningful analyses. Our field results with pentaene and the unresolved complexity of the taxonomy, ecology, and management of southern coneworms support the need for a comprehensive examination of the chemical ecology of Dioryctria spp. PMID:20857730

  16. Design, synthesis, and biological evaluation of 1,9-diheteroarylnona-1,3,6,8-tetraen-5-ones as a new class of anti-prostate cancer agents.

    PubMed

    Zhang, Xiaojie; Wang, Rubing; Perez, German Ruiz; Chen, Guanglin; Zhang, Qiang; Zheng, Shilong; Wang, Guangdi; Chen, Qiao-Hong

    2016-10-01

    In search of more effective chemotherapeutics for the treatment of castration-resistant prostate cancer and inspired by curcumin analogues, twenty five (1E,3E,6E,8E)-1,9-diarylnona-1,3,6,8-tetraen-5-ones bearing two identical terminal heteroaromatic rings have been successfully synthesized through Wittig reaction followed by Horner-Wadsworth-Emmons reaction. Twenty-three of them are new compounds. The WST-1 cell proliferation assay was employed to assess their anti-proliferative effects toward both androgen-sensitive and androgen-insensitive human prostate cancer cell lines. Eighteen out of twenty-five synthesized compounds possess significantly improved potency as compared with curcumin. The optimal compound, 78, is 14- to 23-fold more potent than curcumin in inhibiting prostate cancer cell proliferation. It can be concluded from our data that 1,9-diarylnona-1,3,6,8-tetraen-5-one can serve as a new potential scaffold for the development of anti-prostate cancer agents and that pyridine-4-yls and quinolin-4-yl act as optimal heteroaromatic rings for the enhanced potency of this scaffold. Two of the most potent compounds, 68 and 75, effectively suppress PC-3 cell proliferation by activating cell apoptosis and by arresting cell cycle in the G0/G1 phase. PMID:27543391

  17. Molecular magnetism of M6 hexagon ring in D(3d) symmetric [(MCl)6(XW9O33)2](12-) (M = Cu(II) and Mn(II), X = Sb(III) and As(III)).

    PubMed

    Yamase, Toshihiro; Ishikawa, Hirofumi; Abe, Hiroko; Fukaya, Keisuke; Nojiri, Hiroyuki; Takeuchi, Hideo

    2012-04-16

    Ferromagnetic [n-BuNH(3)](12)[(CuCl)(6)(SbW(9)O(33))(2)]·6H(2)O (1) and antiferromagnetic [n-BuNH(3)](12)[(MnCl)(6)(AsW(9)O(33))(2)]·6H(2)O (4) have been synthesized and structurally and magnetically characterized. Two complexes are structural analogues of [n-BuNH(3)](12)[(CuCl)(6)(AsW(9)O(33))(2)]·6H(2)O (2) and [n-BuNH(3)](12)[(MnCl)(6)(SbW(9)O(33))(2)]·6H(2)O (3) with their ferromagnetic interactions, first reported by us in 2006. (1) When variable temperature (T) direct current (dc) magnetic susceptibility (χ(M)) data are analyzed with the isotropic exchange Hamiltonian for the magnetic exchange interactions, χ(M)T vs T curves fitted by a full matrix diagonalization (for 1) and by the Kambe vector coupling method/Van Vleck's approximation (for 4) yield J = +29.5 and -0.09 cm(-1) and g = 2.3 and 1.9, respectively. These J values were significantly distinguished from +61.0 and +0.14 cm(-1) for 2 and 3, respectively. The magnetization under the pulsed field (up to 10(3) T/s) at 0.5 K exhibits hysteresis loops in the adiabatic process, and the differential magnetization (dM/dB) plots against the pulsed field display peaks characteristic of resonant quantum tunneling of magnetization (QTM) at Zeeman crossed fields, indicating single-molecule magnets for 1-3. High-frequency ESR (HFESR) spectroscopy on polycrystalline samples provides g(∥) = 2.30, g(⊥) = 2.19, and D = -0.147 cm(-1) for 1 (S = 3 ground state), g(∥) = 2.29, g(⊥) = 2.20, and D = -0.145 cm(-1) for 2 (S = 3), and g(∥) = 2.03 and D = -0.007 cm(-1) for 3 (S = 15). An attempt to rationalize the magnetostructural correlation among 1-4, the structurally and magnetically modified D(3d)-symmetric M (=Cu(II) and Mn(II))(6) hexagons sandwiched by two diamagnetic α-B-[XW(9)O(33)](9-) (X = Sb(III) and As(III)) ligands through M-(μ(3)-O)-W linkages, is made. The strongest ferromagnetic coupling for the Cu(6) hexagon of 2, the structure of which approximately provides the Cu(6)(μ(3)-O)(12

  18. Conformational analysis of four spiro6cyclohexane-1,3prime;-indolin9-2prime;-one derivatives

    NASA Astrophysics Data System (ADS)

    Halász, Judit; Podányi, Benjamin; Sánta-Csutor, Andrea; Böcskei, Zsolt; Simon, Kálmán; Hanusz, Miklós; Hermecz, István

    2003-06-01

    SR 121463 is a potent and selective, orally active vasopressin V 2 receptor antagonist. During the synthesis of SR 121463, the formation of the stereochemistry of the cyclohexyl moiety is one of the most important steps. Conformational analysis (via NMR studies and, for cis- 3, also via X-ray structure determination) of the isomers obtained in this step is reported.

  19. 22 CFR 9.6 - Derivative classification.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... CFR 2001.22. (c) Department of State Classification Guide. The Department of State Classification... Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.6 Derivative...'s classified Web site....

  20. 22 CFR 9.6 - Derivative classification.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... CFR 2001.22. (c) Department of State Classification Guide. The Department of State Classification... Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.6 Derivative...'s classified Web site....

  1. Synthesis and Thermodynamic Stability of Ba2B‧B″O6 and Ba3B*B″2O9 Perovskites Using the Molten Salt Method

    NASA Astrophysics Data System (ADS)

    Meng, Wei; Virkar, Anil V.

    1999-12-01

    A number of mixed perovskites of the types Ba2B‧B″O6 (BaB‧1/2B″1/2O3) and Ba3B*B″2O9 (BaB*1/3B″2/3O3) where B‧=Gd, La, Nd, Sm, or Y; B″=Nb and B*=Ca were synthesized by a conventional calcination process, as well as by the molten salt method. The former consists of calcining appropriate mixtures of oxide or carbonate precursors in air at elevated temperatures (∼1250°C). The latter method consists of adding appropriate mixtures of oxide or carbonate precursors to a molten salt bath at relatively low temperatures (on the order of 300 to 500°C) so that the requisite compound is formed by dissolution-reprecipitation. X-ray diffraction confirmed the formation of a single-phase perovskite in each case with calcination at 1250°C. In a molten salt bath, however, all except Ba2LaNbO6 and Ba2NdNbO6 formed the perovskite structure. On the contrary, powders of Ba2LaNbO6 and Ba2NdNbO6 formed by a high-temperature calcination process readily decomposed when introduced into the molten salt bath. The formation of the requisite perovskite at a temperature as low as 350°C in a molten salt suggests that: (a) The perovskite is stable at 350°C. (b) The molten salt exhibits sufficient precursor solubility for the dissolution-reprecipitation process to occur in a reasonable time. Similarly, the decomposition of Ba2LaNbO6 and Ba2NdNbO6 in a molten salt bath shows that these materials are thermodynamically unstable at the temperature of the molten salt bath.

  2. SARS-CoV ORF-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome

    PubMed Central

    Shi, Chong-Shan; Qi, Hai-Yan; Boularan, Cedric; Huang, Ning-Na; Abu-Asab, Mones; Shelhamer, James H.; Kehrl, John H.

    2014-01-01

    Coronaviruses (CoV) have recently emerged as potentially serious pathogens that can cause significant human morbidity and death. The severe acute respiratory syndrome (SARS)-CoV was identified as the etiologic agent of the 2002-3 international SARS outbreak. Yet how SARS evades innate immune responses to cause human disease remains poorly understood. Here, we show that a protein encoded by SARS-CoV designated as open reading frame-9b (ORF-9b) localizes to mitochondria and causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin-like protein (DRP1), a host protein involved in mitochondrial fission. Also, acting on mitochondria ORF-9b targets the mitochondrial-associated adaptor molecule MAVS signalosome by usurping poly(C)-binding protein 2 (PCBP2) and the HECT domain E3 ligase AIP4 to trigger the degradation of MAVS, TRAF3, and TRAF6. This severely limits host cell interferon responses. Reducing either PCBP2 or AIP4 expression substantially reversed the ORF-9b mediated reduction of MAVS and the suppression of anti-viral transcriptional responses. Finally, transient ORF-9b expression led to a strong induction of autophagy in cells. The induction of autophagy depended upon ATG5, a critical autophagy regulator, but the inhibition of MAVS signaling did not. These results indicate that SARS-CoV ORF-9b manipulates host cell mitochondria and mitochondrial function to help evade host innate immunity. This study has uncovered an important clue to the pathogenesis of SARS-CoV infection and illustrates the havoc that a small open reading frame can cause in cells. PMID:25135833

  3. Crystal structure of 9-(3-bromo-5-chloro-2-hydroxy­phen­yl)-10-(2-hy­droxy­eth­yl)-3,3,6,6-tetra­methyl-3,4,6,7,9,10-hexa­hydro­acridine-1,8(2H,5H)-dione

    PubMed Central

    Abdelhamid, Antar A.; Mohamed, Shaaban K.; Simpson, Jim

    2014-01-01

    The title compound C25H29BrClNO4, comprises a 3,3,6,6-tetra­methyl­tetra­hydro­acridine-1,8-dione ring system that carries a hy­droxy­ethyl substituent on the acridine N atom and a 3-bromo-5-chloro-2-hy­droxy­phenyl ring on the central methine C atom of the di­hydro­pyridine ring. The benzene ring is inclined to the acridine ring system at an angle of 89.84 (6)° and this conformation is stabilized by an intra­molecular O—H⋯O hydrogen bond between the hy­droxy substituent on the benzene ring and one of the carbonyl groups of the acridinedione unit. In the crystal, O—H⋯O, C—H⋯O and C—H⋯Br hydrogen bonds combine to stack mol­ecules in inter­connected columns propagating along the a-axis direction. PMID:25249850

  4. Analysis of the ν 8+ ν 9Band of HNO 3, Line Positions and Intensities, and Resonances Involving the v6= v7= 1 Dark State

    NASA Astrophysics Data System (ADS)

    Perrin, A.; Flaud, J.-M.; Keller, F.; Goldman, A.; Blatherwick, R. D.; Murcray, F. J.; Rinsland, C. P.

    1999-03-01

    Using a high-resolution (R= 0.0025 cm-1) Fourier transform spectrum of nitric acid recorded at room temperature in the 1100-1240 cm-1region, it has been possible to perform a more extended analysis of the ν8+ ν9band of HNO3centered at 1205.7075 cm-1. As in a recent analysis of this band [W. F. Wang, P. P. Ong, T. L. Tan, E. C. Looi, and H. H. Teo,J. Mol. Spectrosc.183, 407-413 (1997)], the Hamiltonian used for the line positions calculation takes into account, for the upper state, the ΔK= ±2 anharmonic resonance linking the rotational levels of thev8=v9= 1 "bright" vibrational state and those of the "dark"v6=v7= 1 vibrational state. More than 4800 lines were assigned in the ν8+ ν9band, which involve significantly higher rotational quantum numbers than in previous works. On the other hand, and surprisingly as compared to previous studies, the ν8+ ν9band appears to be a hybrid band. In fact, nonnegligibleB-type transitions could be clearly identified among the much strongerA-type lines. Accordingly, a set of individual line intensities were measured for lines of both types and were introduced in a least-squares fit to get theA- andB-type components of the transition moment operator. Finally, a synthetic spectrum of the 8.3-μm region of HNO3has been generated, using for the line positions and line intensities the Hamiltonian constants and the expansion of the transition moment operator which were determined in this work. In this way, theB-type and theA-type components of the ν8+ ν9band appear to contribute for about {1}/{4} and {3}/{4}, respectively, to the total band intensity.

  5. 9 CFR 83.6 - Testing requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Testing requirements. 83.6 Section 83.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS VIRAL HEMORRHAGIC...

  6. 9 CFR 83.6 - Testing requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Testing requirements. 83.6 Section 83.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS VIRAL HEMORRHAGIC...

  7. 9 CFR 83.6 - Testing requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Testing requirements. 83.6 Section 83.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS VIRAL HEMORRHAGIC...

  8. 9 CFR 392.6 - Public display.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Public display. 392.6 Section 392.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND... be available for public inspection in the FSIS docket room and will be posted on the FSIS Web site...

  9. 9 CFR 392.6 - Public display.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Public display. 392.6 Section 392.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND... be available for public inspection in the FSIS docket room and will be posted on the FSIS Web site...

  10. 9 CFR 102.6 - Conditional licenses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Conditional licenses. 102.6 Section 102.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR...

  11. 9 CFR 102.6 - Conditional licenses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Conditional licenses. 102.6 Section 102.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR...

  12. 9 CFR 102.6 - Conditional licenses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Conditional licenses. 102.6 Section 102.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR...

  13. 9 CFR 101.6 - Cell cultures.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Cell cultures. 101.6 Section 101.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES... more subcultures from the tissue of origin. (c) Subculture. Each flask to flask transfer or...

  14. 9 CFR 101.6 - Cell cultures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Cell cultures. 101.6 Section 101.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES... more subcultures from the tissue of origin. (c) Subculture. Each flask to flask transfer or...

  15. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND... and duplication. See 7 CFR 1.17. Fees to be charged are in 7 CFR part 1, subpart A, appendix A....

  16. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND... and duplication. See 7 CFR 1.17. Fees to be charged are in 7 CFR part 1, subpart A, appendix A....

  17. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND... and duplication. See 7 CFR 1.17. Fees to be charged are in 7 CFR part 1, subpart A, appendix A....

  18. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND... and duplication. See 7 CFR 1.17. Fees to be charged are in 7 CFR part 1, subpart A, appendix A....

  19. 9 CFR 390.6 - Fee schedule.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Fee schedule. 390.6 Section 390.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND... and duplication. See 7 CFR 1.17. Fees to be charged are in 7 CFR part 1, subpart A, appendix A....

  20. 9 CFR 102.6 - Conditional licenses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Conditional licenses. 102.6 Section 102.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR...

  1. 9 CFR 102.6 - Conditional licenses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Conditional licenses. 102.6 Section 102.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS LICENSES FOR...

  2. Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD

    Integrated Risk Information System (IRIS)

    Hexachlorodibenzo - p - dioxin ( HxCDD ) , mixture of 1,2,3,6,7,8 - HxCDD and 1,2,3,7,8,9 - HxCDD ; CASRN 57653 - 85 - 7 and 19408 - 74 - 3 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in

  3. Theoretical investigation of a novel high density cage compound 4,8,11,14,15-pentanitro-2,6,9,13-tetraoxa-4,8,11,14,15-pentaazaheptacyclo[5.5.1.1(3,11).1(5,9)] pentadecane.

    PubMed

    Lin, He; Zhu, Shun-guan; Zhang, Lin; Peng, Xin-hua; Chen, Peng-yuan; Li, Hong-zhen

    2013-03-01

    A novel polynitro cage compound 4,8,11,14,15-pentanitro-2,6,9,13-tetraoxa-4,8,11,14,15-pentaazaheptacyclo [5.5.1.1(3,11).1(5,9)]pentadecane(PNTOPAHP) has been designed and investigated at the DFT-B3LYP/6-31(d) level. Properties, such as electronic structure, IR spectrum, heat of formation, thermodynamic properties and crystal structure have been predicted. This compound is most likely to crystallize in C2/c space group, and the corresponding cell parameters are Z = 8, a = 29.78 Å, b = 6.42 Å, c = 32.69 Å, α = 90.00°, β = 151.05°, γ = 90.00° and ρ = 1.94 g/cm(3). In addition, the detonation velocity and pressure have also been calculated by the empirical Kamlet-Jacobs equation. As a result, the detonation velocity and pressure of this compound are 9.82 km/s, 44.67 GPa, respectively, a little higher than those of 4,10-dinitro-2,6,8,12-tetraoxa-4,10-diazaisowurtzitane(TEX, 9.28 km/s, 40.72 GPa). This compound has a comparable chemical stability to TEX, based on the N-NO(2) trigger bond length analysis. The bond dissociation energy ranges from 153.09 kJ mol(-1) to 186.04 kJ mol(-1), which indicates that this compound meets the thermal stability requirement as an exploitable HEDM. PMID:23111684

  4. 6 alpha-Fluoro- and 6 alpha,9 alpha-difluoro-11 beta,21-dihydroxy-16 alpha,17 alpha-propylmethylenedioxypregn-4-ene-3,20-dione: synthesis and evaluation of activity and kinetics of their C-22 epimers.

    PubMed

    Thalén, B A; Axelsson, B I; Andersson, P H; Brattsand, R L; Nylander, B; Wickström, L I

    1998-01-01

    It is generally accepted that the anti-inflammatory effect of glucocorticosteroids cannot be separated from their adverse effects at the receptor level. However, modification of the pharmacokinetics through structural alterations could provide steroids with a better therapeutic index than those currently used. Thus, new 16 alpha,17 alpha-acetals between butyraldehyde and 6 alpha-fluoro- or 6 alpha,9 alpha-difluoro-16 alpha-hydroxycortisol were synthesized and studied. Acetalization of the corresponding 16 alpha,17 alpha-diols or transacetalization of their 16 alpha,17 alpha-acetonides in dioxane produced mixtures of C-22 epimers, which were resolved by preparative chromatography. Alternatively, an efficient method was used to produce the 22R-epimer stereoselectively through performing the acetalization and transacetalization in a hydrocarbon with an inert material present. The C-22 configuration of (22R)-6 alpha,9 alpha-difluoro-11 beta,21-dihydroxy-16 alpha,17 alpha-propylmethylenedioxypregn-4-ene-3,20-dione was unambiguously established by single crystal X-ray diffraction. The present compounds, especially the 22R-epimer just mentioned, bind to the rat thymus glucocorticoid receptor with high potency. The C-22 epimers of the 6 alpha,9 alpha-difluoro derivatives showed a 10-fold higher biotransformation rate than the budesonide 22R-epimer when incubated with human liver S9 subcellular fraction. The high receptor affinity in combination with the high biotransformation rate indicates that (22R)-6 alpha,9 alpha-difluoro-11 beta,21-dihydroxy-16 alpha,17 alpha-propylmethylenedioxypregn-4-ene-3,20-dione may be an improved 16 alpha,17 alpha-acetal glucocorticosteroid for therapy of inflammatory diseases, in which the mucous membranes are involved, such as those in the intestinal tract as well in the respiratory tract. PMID:9437793

  5. Crystal structure of 10-benzyl-9-(3,4-di­meth­oxy­phen­yl)-3,3,6,6-tetra­methyl-3,4,6,7,9,10-hexa­hydro­acridine-1,8(2H,5H)-dione

    PubMed Central

    Sureshbabu, N.; Sughanya, V.

    2015-01-01

    In the acridinedione moiety of the title compound, C32H37NO4, the central di­hydro­pyridine ring adopts a flattened-boat conformation, with the N atom and the methine C atom displaced from the mean plane of the other four atoms by 0.0513 (14) and 0.1828 (18) Å, respectively. The two cyclo­hexenone rings adopt envelope conformations, with the tetra­subsituted C atoms as the flap atoms. The 3,4-di­meth­oxy­­benzene and benzyl rings are almost normal to the di­hydro­pyridine mean plane, with dihedral angles of 89.47 (9) and 82.90 (11)°, respectively. In the crystal, mol­ecules are linked via a pair of C—H⋯O hydrogen bonds, forming inversion dimers, which are, in turn, linked by C—H⋯O hydrogen bonds, forming slabs lying parallel to (001). PMID:26396906

  6. Pharmacogenetics in American Indian Populations: Analysis of CYP2D6, CYP3A4, CYP3A5, and CYP2C9 in the Confederated Salish and Kootenai Tribes

    PubMed Central

    Fohner, Alison; Muzquiz, LeeAnna I.; Austin, Melissa A.; Gaedigk, Andrea; Gordon, Adam; Thornton, Timothy; Rieder, Mark J.; Pershouse, Mark A.; Putnam, Elizabeth A.; Howlett, Kevin; Beatty, Patrick; Thummel, Kenneth E.; Woodahl, Erica L.

    2014-01-01

    Objectives Cytochrome P450 enzymes play a dominant role in drug elimination and variation in these genes is a major source of interindividual differences in drug response. Little is known, however, about pharmacogenetic variation in American Indian and Alaska Native (AI/AN) populations. We have developed a partnership with the Confederated Salish and Kootenai Tribes (CSKT) in northwestern Montana to address this knowledge gap. Methods We resequenced CYP2D6 in 187 CSKT subjects and CYP3A4, CYP3A5, and CYP2C9 in 94 CSKT subjects. Results We identified 67 variants in CYP2D6, 15 in CYP3A4, 10 in CYP3A5, and 41 in CYP2C9. The most common CYP2D6 alleles were CYP2D6*4 and *41 (20.86 and 11.23%, respectively). CYP2D6*3, *5, *6, *9, *10, *17, *28, *33, *35, *49, *1xN, *2xN, and *4xN frequencies were less than 2%. CYP3A5*3, CYP3A4*1G, and *1B were detected with frequencies of 92.47, 26.81, and 2.20%, respectively. Allelic variation in CYP2C9 was low: CYP2C9*2 (5.17%) and *3 (2.69%). In general, allele frequencies in CYP2D6, CYP2C9 and CYP3A5 were similar to those observed in European Americans. There was, however, a marked divergence in CYP3A4 for the CYP3A4*1G allele. We also observed low levels of linkage between CYP3A4*1G and CYP3A5*1 in the CSKT. The combination of nonfunctional CYP3A5*3 and putative reduced function CYP3A4*1G alleles may predict diminished clearance of CYP3A substrates. Conclusions These results highlight the importance of conducting pharmacogenomic research in AI/AN populations and demonstrate that extrapolation from other populations is not appropriate. This information could help to optimize drug therapy for the CSKT population. PMID:23778323

  7. Synthesis and structural study of 4-(2-chlorophenyl)-2-ethoxy-5,6,7,8,9,10-hexahydrocycloocta[B]pyridine-3-carbonitrile

    NASA Astrophysics Data System (ADS)

    Fathima, K. Saiadali; Vasumathi, M.; Anitha, K.

    2016-05-01

    The novel organic material C20H21ClN2O was synthesized by One-Pot synthesis method and the single crystals were grown by slow evaporation solution growth technique. The crystal structure was elucidated by subjecting the grown crystals to the single crystal x-ray diffraction analysis and was refined by full matrix least-squares method to R=0.039 for 2746 reflections. Crystal system of the grown crystal was found to be monoclinic with the space group P21/a and a=9.196(4) Å, b=13.449(4) Å, c=14.818(4) Å, β= 101.542(3)°, V=1795.6(11) Å3 and Z=4. In this crystal structure, cyclooctanone prefers to reside in a chair-boat conformation. The structure is stabilized by attractive molecular force such as CH/π interaction called hydrophobic interaction.

  8. Vibrational spectroscopy of the borate mineral tunellite SrB6O9(OH)2·3(H2O) - Implications for the molecular structure

    NASA Astrophysics Data System (ADS)

    Frost, Ray L.; López, Andrés; Scholz, Ricardo; Xi, Yunfei

    2014-02-01

    Tunellite is a strontium borate mineral with formula: SrB6O9(OH)2·3(H2O) and occurs as colorless crystals in the monoclinic pyramidal crystal system. An intense Raman band at 994 cm-1 was assigned to the BO stretching vibration of the B2O3 units. Raman bands at 1043, 1063, 1082 and 1113 cm-1 are attributed to the in-plane bending vibrations of trigonal boron. Sharp Raman bands observed at 464, 480, 523, 568 and 639 cm-1 are simply defined as trigonal and tetrahedral borate bending modes. The Raman spectrum clearly shows intense Raman bands at 3567 and 3614 cm-1, attributed to OH units. The molecular structure of a natural tunellite has been assessed by using vibrational spectroscopy.

  9. Graphitic carbon nitride C{sub 6}N{sub 9}H{sub 3}.HCl: Characterisation by UV and near-IR FT Raman spectroscopy

    SciTech Connect

    McMillan, Paul F.; Lees, Victoria; Quirico, Eric; Sella, Andrea; Reynard, Bruno; Simon, Patrick; Bailey, Edward; Deifallah, Malek; Cora, Furio

    2009-10-15

    The graphitic layered compound C{sub 6}N{sub 9}H{sub 3}.HCl was prepared by reaction between melamine and cyanuric chloride under high pressure-high temperature conditions in a piston cylinder apparatus and characterised using SEM, powder X-ray diffraction, UV Raman and near-IR Fourier transform Raman spectroscopy with near-IR excitation. Theoretical calculations using density functional methods permitted evaluation of the mode of attachment of H atoms to nitrogen sites in the structure and a better understanding of the X-ray diffraction pattern. Broadening in the UV and near-IR FT Raman spectra indicate possible disordering of the void sites within the graphitic layers or it could be due to electron-phonon coupling effects. - Graphical abstract: The graphitic layered compound C{sub 6}N{sub 9}H{sub 3}.HCl was prepared by reaction between melamine and cyanuric chloride under high pressure-high temperature conditions in a piston cylinder apparatus and characterised using SEM, powder X-ray diffraction, UV Raman and near-IR Fourier transform Raman spectroscopy using near-IR excitation. Theoretical calculations using density functional methods permitted evaluation of the mode of attachment of H atoms to nitrogen sites around the C{sub 12}N{sub 12} voids within the layered structure and also led to better understanding of the X-ray diffraction pattern. Sharp peaks in the UV Raman spectra are due to C{sub 3}N{sub 3} triazine ring units in the structure, that may be enhanced by resonance Raman effects. Broadening in the UV and near-IR FT Raman spectra indicate possible disordering within the graphitic layers or electron-phonon coupling effects.

  10. Human fructose-1,6-bisphosphatase gene (FBP1): Exon-intron organization, localization to chromosome bands 9q22.2-q22.3, and mutation screening in subjects with fructose-1,6-bisphosphatase deficiency

    SciTech Connect

    El-Maghrabi, M.R.; Jiang, W.

    1995-06-10

    Fructose-1,6-bisphosphatase (EC 3.1.3.11) is a key regulatory enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose-1,6-bisphosphate to generate fructose-6-phosphate and inorganic phosphate. Deficiency of fructose-1,6-bisphosphatase is associated with fasting hypoglycemia and metabolic acidosis because of impaired gluconeogenesis. We have cloned and characterized the human liver fructose-1,6-bisphosphatase gene (FBP1). FBP1, localized to chromosome bands 9q22.2-q22.3 by fluorescence in situ hybridization, consists of seven exons that span > 31 kb, and the six introns are in the same position as in the rat gene. FBP1 was screened for mutations in two subjects with fructose-1,6-bisphosphatase deficiency. Four nucleotide substitutions were identified, two of which were silent mutations in the codons for Ala-216 (GCT {yields} GCC) and Gly-319 (GGG {yields} GGA). The other substitutions were in intron 3, a C {yields} T substitution 7 nucleotides downstream from the splice donor site, and in the promoter region, an A {yields} T substitution 188 nucleotides upstream from the start of transcription. These nucleotide substitutions were also found in normal unaffected subjects and thus are not the cause of fructose-1,6-bisphosphatase deficiency in the two subjects studied. The molecular basis of hepatic fructose-1,6-bisphosphatase deficiency in these subjects remains undetermined but could result from unidentified mutations in the promoter that decrease expression or from mutations in another gene that indirectly lead to decreased fructose-1,6-bisphosphatase activity. 18 refs., 3 figs., 3 tabs.

  11. DNA Sequence Modulates Geometrical Isomerism of the trans-8,9-Dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy Aflatoxin B1 Adduct

    PubMed Central

    2016-01-01

    Aflatoxin B1 (AFB1), a mycotoxin produced by Aspergillus flavus, is oxidized by cytochrome P450 enzymes to aflatoxin B1-8,9-epoxide, which alkylates DNA at N7-dG. Under basic conditions, this N7-dG adduct rearranges to yield the trans-8,9-dihydro-8-(2,6-diamino-4-oxo-3,4-dihydropyrimid-5-yl-formamido)-9-hydroxy aflatoxin B1 (AFB1–FAPY) adduct. The AFB1–FAPY adduct exhibits geometrical isomerism involving the formamide moiety. NMR analyses of duplex oligodeoxynucleotides containing the 5′-XA-3′, 5′-XC-3′, 5′-XT-3′, and 5′-XY-3′ sequences (X = AFB1–FAPY; Y = 7-deaza-dG) demonstrate that the equilibrium between E and Z isomers is controlled by major groove hydrogen bonding interactions. Structural analysis of the adduct in the 5′-XA-3′ sequence indicates the preference of the E isomer of the formamide group, attributed to formation of a hydrogen bond between the formyl oxygen and the N6 exocyclic amino group of the 3′-neighbor adenine. While the 5′-XA-3′ sequence exhibits the E isomer, the 5′-XC-3′ sequence exhibits a 7:3 E:Z ratio at equilibrium at 283 K. The E isomer is favored by a hydrogen bond between the formyl oxygen and the N4-dC exocyclic amino group of the 3′-neighbor cytosine. The 5′-XT-3′ and 5′-XY-3′ sequences cannot form such a hydrogen bond between the formyl oxygen and the 3′-neighbor T or Y, respectively, and in these sequence contexts the Z isomer is favored. Additional equilibria between α and β anomers and the potential to exhibit atropisomers about the C5–N5 bond do not depend upon sequence. In each of the four DNA sequences, the AFB1–FAPY adduct maintains the β deoxyribose configuration. Each of these four sequences feature the atropisomer of the AFB1 moiety that is intercalated above the 5′-face of the damaged guanine. This enforces the Ra axial conformation for the C5–N5 bond. PMID:25587868

  12. Science for Grades 6-9.

    ERIC Educational Resources Information Center

    Nederland Independent School District, TX.

    GRADES OR AGES: Grades 6-9. SUBJECT MATTER: General science, life science, earth science, and physical science. ORGANIZATION AND PHYSICAL APPEARANCE: The guide is divided into separate sections for each grade. Each section is further subdivided into units. The major portion of each unit is laid out in four columns; column headings are concepts,…

  13. 22 CFR 9.6 - Derivative classification.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.6 Derivative... CFR 2001.22. (c) Department of State Classification Guide. The Department of State Classification... generating in new form information that is already classified and the marking of the new material...

  14. 22 CFR 9.6 - Derivative classification.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.6 Derivative... CFR 2001.22. (c) Department of State Classification Guide. The Department of State Classification... generating in new form information that is already classified and the marking of the new material...

  15. 22 CFR 9.6 - Derivative classification.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Foreign Relations DEPARTMENT OF STATE GENERAL SECURITY INFORMATION REGULATIONS § 9.6 Derivative... CFR 2001.22. (c) Department of State Classification Guide. The Department of State Classification... generating in new form information that is already classified and the marking of the new material...

  16. In vitro activities of 3-hydroxy-1,5,6-trimethoxy-2-methyl-9,10-anthraquinone against non-small cell lung carcinoma.

    PubMed

    Feng, Shi-Xiu; Guan, Qiunong; Chen, Tao; Du, Caigan

    2012-07-01

    Medicinal herbs are the preferred candidates for drug discovery against human diseases including cancer. The roots of Prismatomeris connata have been used in traditional herbal medicine to treat many health problems, particularly pneumoconiosis. This study was to test the anti-tumor activity of 3-hydroxy-1,5,6-trimethoxy-2-methyl-9,10-anthraquinone (PCON6), a major anthraquinone derivative from C. connata, against lung cancer. Cell viability in cultures was assessed by MTT assay. Cell death or apoptosis was determined with annexin-V and 7-aminoactinomycin D staining. Cell cycle was analyzed by both propidium iodide DNA staining and BrdU incorporation assay. Here we showed that in a panel of fifteen different tumor cells lines, a group of four non-small cell lung carcinoma (NSCLC) cell lines exhibited a relatively higher sensitivity to PCON6 growth inhibition than the rest of most non-lung cancer cell lines (p = 0.0461). Further studies demonstrated that the suppression of NSCLC H520 cell growth by PCON6 was associated with its induction of apoptosis at 20 μM (p = 0.0008), and of cell accumulation at S phase cell cycle (p < 0.05) that was further supported by a decrease in cdc2 protein expression. This preliminary study suggests that natural compound PCON6 has relatively selective cytotoxicity against NSCLC growth and represent a concept of developing a novel drug therapy specific for NSCLC based on the roots of C. connata or PCON6. PMID:22864748

  17. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation.

    PubMed

    Zhao, Xue-Qiang; Zhu, Le-Le; Chang, Qing; Jiang, Changying; You, Yun; Luo, Tianming; Jia, Xin-Ming; Lin, Xin

    2014-10-24

    Previous studies indicate that both Dectin-3 (also called MCL or Clec4d) and Mincle (also called Clec4e), two C-type lectin receptors, can recognize trehalose 6,6'-dimycolate (TDM), a cell wall component from mycobacteria, and induce potent innate immune responses. Interestingly, stimulation of Dectin-3 by TDM can also induce Mincle expression, which may enhance the host innate immune system to sense Mycobacterium infection. However, the mechanism by which Dectin-3 induces Mincle expression is not fully defined. Here, we show that TDM-induced Mincle expression is dependent on Dectin-3-mediated NF-κB, but not nuclear factor of activated T-cells (NFAT), activation, and Dectin-3 induces NF-κB activation through the CARD9-BCL10-MALT1 complex. We found that bone marrow-derived macrophages from Dectin-3-deficient mice were severely defective in the induction of Mincle expression in response to TDM stimulation. This defect is correlated with the failure of TDM-induced NF-κB activation in Dectin-3-deficient bone marrow-derived macrophages. Consistently, inhibition of NF-κB, but not NFAT, impaired TDM-induced Mincle expression, whereas NF-κB, but not NFAT, binds to the Mincle promoter. Dectin-3-mediated NF-κB activation is dependent on the CARD9-Bcl10-MALT1 complex. Finally, mice deficient for Dectin-3 or CARD9 produced much less proinflammatory cytokines and keyhole limpet hemocyanin (KLH)-specific antibodies after immunization with an adjuvant containing TDM. Overall, this study provides the mechanism by which Dectin-3 induces Mincle expression in response to Mycobacterium infection, which will have significant impact to improve adjuvant and design vaccine for antimicrobial infection. PMID:25202022

  18. Study on luminescent properties of Eu3+ doped Gd2WO6, Gd2W2O9 and Gd2(WO4)3 nanophosphors prepared by co-precipitation.

    PubMed

    Meng, Qingyu; Hua, Ruinian; Chen, Baojiu; Tian, Yue; Lu, Shuchen; Sun, Linan

    2011-01-01

    Eu3+ doped Gd2WO6, Gd2W2O9 and Gd2(WO4)3 nanophosphors with different concentrations have been prepared by co-precipitation. XRD (X-ray diffraction) and SEM (scanning electron microscopy) were used to investigate the structure and morphology. The emission spectra, excitation spectra and fluorescence decay curves were measured, and partial J-O parameters and quantum efficiencies of Eu3+ 5D0 energy level were calculated. Furthermore, concentration quenching curves of Eu3+ in different hosts were drawn. The photoluminescent properties of Eu3+ doped Gd2WO6, Gd2W2O9 and Gd2(WO4)3 nanophosphors have been studied. The results indicate that Eu3+ 5D0-7F2 red luminescence can be effectively excited by 395 nm and 465 nm in Gd2WO6 and Gd2W2O9 hosts, similar to the familiar Gd2(WO4)3:Eu. Especially Gd2W2O9:Eu has strong red emission and high quenching concentration, so it has potential applications for trichromatic white LED as red fluorescent materials. PMID:21446424

  19. RDamage 6, 7, 8 & 9 Cassettes

    SciTech Connect

    Griego, Jeffrey R; Kaul, Ann

    2012-06-08

    The RDamage series of ten experiments is part of a long-term collaboration with RFNC/VNIIEF in pulsed power technology. These experiments use a cylindrical configuration to study spallation damage, which allows for a natural recollection of the damaged material under proper driving conditions and post-shot collection of the damaged target material for subsequent metallographic analysis. Dynamic insitu experimental velocimetry diagnostics are also employed. LANL is responsible for the design of the experimental load and velocimetry system. VNIIEF is responsible for the design and construction of the driving explosive magnetic generator. In the RDamage-0, -1 and -2 experiments, data was collected about failure initiation of a well-characterized material (aluminum) in a cylindrical geometry. The RDamage-3, -4 and -5 experiments produced data on the behavior of material recollected after damage from pressures in the damage initiation regime. Data on the behavior of material recollected after complete failure was collected in the RDamage-6, -7, -8 and -9 experiments. This presentation shows the evolution of the load assembly through the experimental series.

  20. LD50 value, phototoxicity and convulsion induction test of the new quinolone antibacterial agent (S)-10-[(S)-(8-amino-6-azaspiro[3,4]octan-6-yl)]-9-fluoro-2, 3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxyl ic acid hemihydrate in laboratory animals.

    PubMed

    Shimoda, K; Akahane, K; Nomura, M; Kato, M

    1996-06-01

    (S)-10-[(S)-(8-Amino-6-azaspiro[3,4]octan-6-yl)]-9-fluoro-2, 3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxyli c acid hemihydrate (CAS 151390-79-3, DV-7751a) a new quinolone antibacterial agent, was examined for LD50 value, phototoxicity and convulsion inducing potential in laboratory animals. A single oral administration of DV-7751a induced soft stool in rats at 1000 and 2000 mg/ kg and in monkeys at 250 mg/kg and vomiting in monkeys at 500 mg/kg or more. A single intravenous administration caused a decrease in locomotor activity, respiratory depression, convulsion, pulmonary edema and death in rats and mice. The LD50 values with oral administration were more than 2000 mg/ kg for rats and mice and more than 250 mg/kg for monkeys, and those with intravenous administration were 164.3 mg/kg for rats of both sexes at an injection rate of 2 ml/min, 118.8 mg/kg for male rats and 104 to 125 mg/kg for female rats at 0.5 ml/min, and 184.7 mg/kg for male mice and 187.4 mg/kg for female mice. DV-7751a showed very weak phototoxicity in mice after single oral administration of 600 mg/kg, followed by UVA irradiation, but no convulsion after oral administration of 200 or 1000 mg/kg in combination with 4-biphenylacetic acid at 400 mg/kg. PMID:8767355

  1. Thermal studies of Se{sub 85-x}Te{sub 15}In{sub x} (x = 3,6,9,12) glasses

    SciTech Connect

    Sushama, D.; George, Achamma; Asokan, S.

    2011-10-20

    Bulk glasses of compositions Se{sub 85-x}Te{sub 15}In{sub x} (x = 3,6,9,12) are prepared by melt quenching technique and Differential scanning calorimetry (DSC) is employed to study the thermal stability, crystallization mechanism as well as specific heat of these glasses. It is found that the addition of indium increases the glass transition temperature. From the heating rate dependence of the glass transition temperature the activation energy of glass transition is determined using Kissinger's equation for non-isothermal crystallization of materials. An attempt has been made to explain the variation in the value of T{sub c}, T{sub p} and {Delta}C{sub p} for the composition Se{sub 73}Te{sub 15}In{sub 12} using rigidity percolation threshold (RPT). From the values of (T{sub c}-T{sub g}) the stable glass system is determined.

  2. Graphitic carbon nitride C 6N 9H 3·HCl: Characterisation by UV and near-IR FT Raman spectroscopy

    NASA Astrophysics Data System (ADS)

    McMillan, Paul F.; Lees, Victoria; Quirico, Eric; Montagnac, Gilles; Sella, Andrea; Reynard, Bruno; Simon, Patrick; Bailey, Edward; Deifallah, Malek; Corà, Furio

    2009-10-01

    The graphitic layered compound C 6N 9H 3·HCl was prepared by reaction between melamine and cyanuric chloride under high pressure-high temperature conditions in a piston cylinder apparatus and characterised using SEM, powder X-ray diffraction, UV Raman and near-IR Fourier transform Raman spectroscopy with near-IR excitation. Theoretical calculations using density functional methods permitted evaluation of the mode of attachment of H atoms to nitrogen sites in the structure and a better understanding of the X-ray diffraction pattern. Broadening in the UV and near-IR FT Raman spectra indicate possible disordering of the void sites within the graphitic layers or it could be due to electron-phonon coupling effects.

  3. Anisotropy of inter-band transitions and band structure of Cs3Zn6B9O21 nonlinear optical crystals

    NASA Astrophysics Data System (ADS)

    Bovgyra, O. V.; Kurlak, V. Y.; Chrunik, M.; Majchrowski, A.; Jaroszewicz, L. R.; Ozga, K.

    2016-06-01

    Polarized optical functions near the fundamental absorption edge of novel Cs3Zn6B9O21 nonlinear optical crystals possessing a wide UV transparency down to 190 nm were investigated. The anisotropy of optical functions is not well studied yet which restrains the further strategy of the formation on its base of solid state compounds with desirable properties. The studies were performed using a band structure calculations as well as the experimental measurements of fundamental polarized UV absorption edge and X-ray photoelectron spectra of the studied crystals. The experimental data were used for evaluation of scissor factors of the band structure. The results of the calculations were compared with the XPS and polarized absorption optical spectra of the investigated crystals. The introduction of the scissor factor was performed in order to obtain a sufficient agreement with experiment. The observed anisotropy of absorption may be explained by the anisotropy of carrier effective masses.

  4. Gapless quantum spin liquid ground state in the spin-1 antiferromagnet 6HB-Ba3NiSb2O9

    NASA Astrophysics Data System (ADS)

    Quilliam, J. A.; Bert, F.; Manseau, A.; Darie, C.; Guillot-Deudon, C.; Payen, C.; Baines, C.; Amato, A.; Mendels, P.

    2016-06-01

    We present an in-depth study of the magnetic properties of the spin-1 antiferromagnet 6HB-Ba3NiSb2O9 . μ SR measurements demonstrate that this material shows no static magnetism down to temperatures as low as 20 mK, making it a likely candidate for a quantum spin liquid state. 121Sb NMR shift measurements show that the local, intrinsic susceptibility levels off at temperatures below ˜60 K. The NMR spin-lattice relaxation rate 1 /T1 is essentially constant in temperature and the muon relaxation rate exhibits a low-temperature relaxation plateau, all indications of gapless spin excitations. Our local probe measurements are discussed in the context of several theories proposed for this material.

  5. Cytotoxicity on Allium cepa of the two main sulcotrione photoproducts, xanthene-1,9-dione-3,4-dihydro-6-methylsulphonyl and 2-chloro-4-mesylbenzoic acid.

    PubMed

    Goujon, Eric; Richard, Claire; Goupil, Pascale; Ledoigt, Gérard

    2015-10-01

    The cytotoxic effects of 2-chloro-4-mesylbenzoic acid (CMBA) and xanthene-1,9-dione-3,4-dihydro-6-methylsulphonyl (XDD), the two main photoproducts of sulcotrione, were investigated on Allium root meristematic cells at different concentrations. Degradation of sulcotrione was correlated to mitotic index decrease, together with increasing anomaly and c-mitosis frequencies. Mitotic index significantly decreased with increasing XDD and CMBA concentrations. Cell frequency with abnormal chromosomes increased with CMBA or XDD application rates. In contrast, CMBA induced a low micronucleus rate even for high concentrations while XDD increased the micronucleus ratio. C-mitoses, chromosomal aberrations due to an inactivation of the spindle, were enhanced by CMBA treatments but not by XDD. The photochemical degradation process of the pesticide can change the risk for the environment. PMID:26453228

  6. 1,8-dihydroxy-3-acetyl-6-methyl-9,10 anthraquinone exhibits a potent radiosensitizing effect with induced oncosis in human nasopharyngeal carcinoma cells.

    PubMed

    Hou, Huaxin; Li, Danrong; Jiang, Wei; Liang, Yan; Chen, Donglian; Mo, Yuanyuan

    2014-08-01

    1,8‑dihydroxy‑3‑acetyl‑6‑methyl‑9,10 anthraquinone (DAMA) was synthesized from emodin. In the present study, the activity and the oncosis‑like mechanism of DAMA‑enhanced nasopharyngeal carcinoma (NPC) cell sensitivity to ionizing radiation was examined. The results demonstrated that DAMA has a 1.46‑fold radiosensitisation activity for nasopharyngeal carcinoma CNE 1 cells with a non‑cytotoxic concentration of 10 µg/ml DAMA combined with 2 Gy. Following treatment of DAMA combined with radiation, CNE‑1 cells revealed severe cytoplasmic swelling and vacuolization, swollen mitochondria and dilation of the nuclei without chromatin condensation, yielding a typical morphology of oncosis. Oncosis‑related gene expression of ATP synthase F0 subunit 6, chromatin modifying protein 6 and cyclophilin D mRNA increased significantly in the 8 Gy radiation group and the 2 Gy radiation combined with DAMA group. A significant decrease of ATP synthase protein 8 mRNA was observed and the levels of intracellular ATP were also reduced. In addition, the levels of intracellular Ca2+ were increased. In conclusion, DAMA is a potent radiation sensitizer in nasopharyngeal carcinoma cells and mediates its radiosensitisation via oncosis. PMID:24912934

  7. Participation of the Cl−/HCO3− Exchangers SLC26A3 and SLC26A6, the Cl− Channel CFTR, and the Regulatory Factor SLC9A3R1 in Mouse Sperm Capacitation1

    PubMed Central

    Chávez, Julio C.; Hernández-González, Enrique O.; Wertheimer, Eva; Visconti, Pablo E.; Darszon, Alberto; Treviño, Claudia L.

    2011-01-01

    ABSTRACT Sperm capacitation is required for fertilization and involves several ion permeability changes. Although Cl− and HCO3− are essential for capacitation, the molecular entities responsible for their transport are not fully known. During mouse sperm capacitation, the intracellular concentration of Cl− ([Cl−]i) increases and membrane potential (Em) hyperpolarizes. As in noncapacitated sperm, the Cl− equilibrium potential appears to be close to the cell resting Em, opening of Cl− channels could not support the [Cl−]i increase observed during capacitation. Alternatively, the [Cl−]i increase might be mediated by anion exchangers. Among them, SLC26A3 and SLC26A6 are good candidates, since, in several cell types, they increase [Cl−]i and interact with cystic fibrosis transmembrane conductance regulator (CFTR), a Cl− channel present in mouse and human sperm. This interaction is known to be mediated and probably regulated by the Na+/H+ regulatory factor-1 (official symbol, SLC9A3R1). Our RT-PCR, immunocytochemistry, Western blot, and immunoprecipitation data indicate that SLC26A3, SLC26A6, and SLC9A3R1 are expressed in mouse sperm, localize to the midpiece, and interact between each other and with CFTR. Moreover, we present evidence indicating that CFTR and SLC26A3 are involved in the [Cl−]i increase induced by db-cAMP in noncapacitated sperm. Furthermore, we found that inhibitors of SLC26A3 (Tenidap and 5099) interfere with the Em changes that accompany capacitation. Together, these findings indicate that a CFTR/SLC26A3 functional interaction is important for mouse sperm capacitation. PMID:21976599

  8. The Microstructure Evolution and Processing Map of Ni-18.3Cr-6.4Co-5.9W-4Mo Superalloy During Hot Deformation

    NASA Astrophysics Data System (ADS)

    Qin, Shengxue; Liu, Jie; Zhang, Hongbin; Zhang, Kaifeng

    2016-06-01

    The processing map and microstructure evolution of Ni-18.3Cr-6.4Co-5.9W-4Mo superalloy were investigated in the temperature range of 1010-1160 °C and strain rate range of 0.001-1 s-1 by means of hot compression tests. According to the processing map, the optimum processing parameters were located in the temperature range of 1100-1160 °C and strain rate range of 0.01-0.3 s-1. The carbides in the alloy contributed to form a fine grain microstructure. In addition, four different instability criteria of Prasad, Gegel, Malas, and Murty were used to predict the unstable domains in the processing map. Meanwhile, the microstructure observations revealed that the unstable domain predicted by Murty's instability criterion was very effective at high strain rate, which was the best choice for the studied alloy. Furthermore, the electron backscattered diffraction technique was used to detect the Σ3 boundaries and the adiabatic shear bands in the alloy. The results revealed that the fractions of Σ3 boundaries in the alloy deformed at 1100 °C/0.01 s-1 and 1160 °C/0.1 s-1 reached about 25 and 27%, respectively. Meanwhile, the fraction of low-angle grain boundaries and dislocation density were relatively high in the adiabatic shear band.

  9. Crystal structure of (9S,10S)-10-eth­oxy-9-hy­droxy-6,6,9-trimethyl-3-pentyl-7,8,9,10-tetra­hydro-6H-benzo[c]chromen-1-yl 4-methyl­benzene­sulfonate

    PubMed Central

    Gul, Waseem; Galal, Ahmed; ElSohly, Mahmoud A.; Carvalho, Paulo

    2015-01-01

    In the structure of the title compound, C30H40O6S, the cyclo­hexene and heterocyclic rings are linked by a double bond. The cyclo­hexene ring has a half-chair conformation (the methyl­ene group adjacent to the hy­droxy substituent lies above the remaining atoms) and the hy­droxy and eth­oxy groups have equatorial and bis­ectional dispositions, respectively. The heterocyclic ring has an envelope conformation (with the CMe2 C atom being the flap). The dihedral angle between the aromatic rings is 53.88 (10)°. A long intra­molecular C—H⋯S inter­action is noted. In the mol­ecular packing, hy­droxy-O—H⋯O(sulfonate) hydrogen bonds lead to a helical chain along [010]. Connections between chains are of the type methyl-C—H⋯O(sulfonate) and lead to supra­molecular layers that lie parallel to (001). The studied crystal was an inversion twin. PMID:26870509

  10. NTP Carcinogenesis Bioassay of Propyl Gallate (CAS No. 121-79-9) in F344/N Rats and B6C3F1 Mice (Feed Study).

    PubMed

    1982-12-01

    Bioassay Program is only 0.86%. The absence of this tumor in the high-dose female rat group reduces the likelihood that this tumor is related to propyl gallate administration. Increased incidences of hepatic cytoplasmic vacuolization and suppurative inflammation of the prostate were observed in dosed male rats. These findings were considered to be related to administration of propyl gallate. Tumors (mostly benign) of the preputial gland, islet-cell tumors of the pancreas, and pheochromocytomas of the adrenal gland were observed with significantly (P<0.05) higher incidences in the low- dose male rats, but there was little evidence of an effect in the high-dose group. The incidences of male rats with tumors of the preputial gland were 1/50 (2%) for controls, 8/50 (16%) for the low-dose, and 0/50 (0%) for the high-dose group. Islet-cell tumors of the pancreas occurred in 2/50 (4%) control males, 9/50 (18%) low-dose males, and 4/50 (8%) for high-dose males. Pheochromocytomas of the adrenal gland were observed in 4/50 (8%) control males, 13/48 (25%) low-dose males, and 8/50 (16%) high-dose males. Negative trends (P<0.05) were observed for leukemia in male rats (16/50, 7/50, 6/50) and for fibroadenomas of the mammary gland in female rats (11/50, 2/50, 5/50). In male mice, malignant lymphoma was observed with a significantly (P3/49, 6%; high-dose, 8/50, 16%), and the incidence in the high-dose group was significantly (P9.4%) for the laboratory that conducted this bioassay. Adenomas of the liver in female mice occurred with a statistically significant (P

  11. 9-(3,4-Dimeth­oxy­phen­yl)-3,3,6,6-tetra­methyl-4,5,6,9-tetra­hydro-3H-xanthene-1,8(2H,7H)-dione

    PubMed Central

    Mehdi, Sayed Hasan; Sulaiman, Othman; Ghalib, Raza Murad; Yeap, Chin Sing; Fun, Hoong-Kun

    2011-01-01

    The asymmetric unit of the title xanthene compound, C25H30O5, contains two mol­ecules in which the pyran ring and the dimeth­oxy­phenyl ring are nearly perpendicular to one another [dihedral angles = 86.81 (8) and 84.45 (9)°]. One of the meth­oxy groups in one mol­ecule is twisted away from the phenyl ring [C—O—C—C torsion angle = −103.40 (16)°]. The pyran ring adopts a boat conformation whereas the two fused cyclo­hexane rings adopt envelope conformations in both mol­ecules. In the crystal, mol­ecules are linked into a three-dimensional network by C—H⋯O hydrogen bonds. PMID:21837111

  12. 36 CFR 6.9 - Permits.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...), the Endangered Species Act (16 U.S.C. 1531-1543), and E.O. 11988, Floodplain Management (3 CFR, 1978 Comp., p. 117), and E.O. 11990, Wetland Protection (3 CFR, 1978 Comp., 121). (c) The Regional Director... groundwater, surface water, explosive gas and other pertinent natural resource monitoring; (6) Rights...

  13. Theoretical study of 3,3‧ substitution of 9,9,9‧,9‧-tetramethyl-fluorene-dimers

    NASA Astrophysics Data System (ADS)

    Barboza, Cristina A.; Arratia-Pérez, Ramiro; Carey, Desmond MacLeod

    2012-06-01

    The effect of the 3,3' substitution in 9,9,9',9'-tetramethyl-fluorene-dimers with electron donor and withdrawing groups was analyzed. Ground state potential energy surfaces were obtained at DFT level using B3LYP/6-31+G(d,p). All studied dimers are nonplanar at their electronic ground states. The electronic transitions were investigated through the time-dependent-DFT method at their optimized ground states. The chemical potential (μ) as well as the HOMO and LUMO eigenvalues were plotted against the Hammet parameters, showing a good linear correlation, giving us insights about the modulation of the electronic properties, e.g. HOMO-LUMO gap, by means of the functionalization of fluorene dimers at strategical positions.

  14. Vibrational spectroscopic study of the copper silicate mineral ajoite (K,Na)Cu7AlSi9O24(OH)6·3H2O

    NASA Astrophysics Data System (ADS)

    Frost, Ray L.; Xi, Yunfei

    2012-06-01

    Ajoite (K,Na)Cu7AlSi9O24(OH)6·3H2O is a mineral named after the Ajo district of Arizona. Raman and infrared spectroscopy were used to characterise the molecular structure of ajoite. The structure of the mineral shows disorder which is reflected in the difficulty of obtaining quality Raman spectra. The Raman spectrum is characterised by a broad spectral profile with a band at 1048 cm-1 assigned to the ν1 (A1g) symmetric stretching vibration. Strong bands at 962, 1015 and 1139 cm-1 are assigned to the ν3 SiO4 antisymmetric stretching vibrations. Multiple ν4 SiO4 vibrational modes indicate strong distortion of the SiO4 tetrahedra. Multiple AlO and CuO stretching bands are observed. Raman spectroscopy and confirmed by infrared spectroscopy clearly shows that hydroxyl units are involved in the ajoite structure. Based upon the infrared spectra, water is involved in the ajoite structure, probably as zeolitic water.

  15. 9-(Thio­phen-2-yl)-8,9-dihydro-3H-pyrazolo­[4,3-f]quinolin-7(6H)-one ethanol monosolvate

    PubMed Central

    Peng, Juhua; Jia, Runhong

    2012-01-01

    In the title compound, C14H11N3OS·C2H5OH, the dihedral angle between the pyridine N—Cfused—Cfused—C(thio­phene) plane and the plane of the thio­phene ring is 81.9 (3)°, indicating that they are close to perpendicular. The dihedral angle between this pyridine plane and the benzene ring is 1.3 (3)°. The thio­phene ring is disordered over two coplanar orientations with an occupancy ratio of 0.692 (7):0.308 (7), while the ethanol solvent mol­ecule is also disordered over two sets of site in a 0.66 (4):0.34 (4) ratio. In the crystal, chains are formed along the b axis by N—H⋯O and O—H⋯N inter­actions with adjacent chains being connected through C—H⋯N and C—H⋯S inter­actions. PMID:22969512

  16. NTP Toxicology and Carcinogenesis Studies of C.I. Basic Red 9 Monohydrochloride (Pararosaniline) (CAS No. 569-61-9) In F344/N Rats and B6C3F1 Mice (Feed Studies).

    PubMed

    1986-01-01

    C.I. Basic Red 9 monohydrochloride is a triphenylmethane dye used for coloring textiles, leather, and paper and as a biological stain. Toxicology and carcinogenesis studies were conducted by administering the test chemical in feed to groups of 50 male and 50 female F344/N rats and B6C3F1 mice for 103 weeks at concentrations of 0, 1,000, or 2,000 ppm for male rats and 0, 500, or 1,000 ppm for female rats and mice of each sex. The average daily doses of C.I. Basic Red 9 monohydrochloride were estimated to be 49 and 103 mg/kg for male rats, 28 and 59 for female rats, 196 and 379 mg/kg for male mice, and 149 and 407 mg/kg for female mice. Two lots of the test chemical were used in the 2-year studies with purities of 93% (water content approximately 9%) and 99%. In rats, the thyroid gland and pituitary gland were identified as target sites in the 13-week studies. Therefore, 10 additional rats of each sex were added to the control and high dose groups in the 2-year studies to examine the effects on these organs after 1 year of exposure. In the 1-year studies in rats, final mean body weights were slightly decreased in both sexes. The thyroid gland weight to body ratio of dosed males was 1.7 times that of the controls, and the concentration of serum thyroxin in male and female rats was significantly lower than that of the controls at week 52. Compound-related histopathologic effects included thyroid gland cysts in both sexes (1/10; 1/10) and thyroid gland follicular cell hyperplasia (1/10), adenomas (1/10), and carcinomas (1/10) and fatty metamorphosis of the liver (4/10, two of these with focal necrosis) in males; no effect was seen in the controls. The doses selected for the 2-year studies were based on the results of the 13-week studies. The absence of toxicologic signs, histopathologic changes, significant body weight depressions, or mortality after 13 weeks of exposure to C.I. Basic Red 9 monohydrochloride suggested that these concentrations would not shorten survival

  17. Reactions of HC triple bond CCMe sub 2 NHCOR alkynes with M sub 3 (CO) sub 12 carbonyls (M = Ru, R = C sub 6 H sub 9 , Ph; M = Os, R = C sub 6 H sub 9 ). Synthesis and crystal structure of Ru sub 4 (CO) sub 11 (HC triple bond CCMe sub 2 NHCOC sub 6 H sub 9 ), a butterfly cluster showing an interaction between a wingtip metal and the amide CO

    SciTech Connect

    Predieri, G.; Tiripicchio, A.; Camellini, M.T.; Costa, M. ); Sappa, E. )

    1990-06-01

    The alkynes HC{triple bond}CCMe{sub 2}NHCOR react with M{sub 3}(CO){sub 12} (M = Ru or Os) giving, upon oxidative addition, the expected hydrides ({mu}-H)M{sub 3}(CO){sub 9}({mu}{sub 3}-{eta}{sup 2}-C{triple bond}CCMe{sub 2}NHCOR) and the unprecedented butterfly clusters M{sub 4}(CO){sub 11}({mu}{sub 4}-{eta}{sup 2}-HC{triple bond}CCME{sub 2}NHCOR). These complexes have been characterized by spectroscopic studies; the structure of the ruthenium butterfly cluster with R = C{sub 6}H{sub 9} has been determined by X-ray diffraction methods. Crystals, containing CHCl{sub 3} as solvation molecules, are triclinic with Z = 2 in a unit cell of dimensions a = 13.521 (6), b = 14.617 (6), c = 9.049 (5) {angstrom}, {alpha} = 79.28 (2), {beta} = 108.79 (2), {gamma} = 111.85 (2){degree}.

  18. Multimeas Version 3.9

    2005-09-02

    The software lets the user do the following: 1. Identify instruments connected through GPIB. 2. Identify which instruments should be used for control. 3. Identify which instruments should sample data. a. Specify name of data. b. Specify instrument. c. Specify instrument-specific measurement. d. Specify scaling factors from pre-ampliflers etc. 4. Identify entities/data columns that should be calculated from data or other data columns and specify these calculations 5. Create a list of measurements to run,more » a. Define file names. b. Define measurement variables (temperature, current, magnetic field, etc.) c. Define measurement limits and ramps or "manual control". d. Define changed condition for each run (new current, etc.) 6. Run, pause, siop, go to next file, create new runs, etc., during measurement. 7. Plot any columns of data. 8. Plot pulse shapes, pulse cycles, FFT, power spectrum etc. 9. Apply real-time filters and damping on data/calculated columns.« less

  19. Thermodynamic properties of underdoped YBa2Cu3O6+x cuprates for doping values x ∈ (0 . 5 , 0 . 9)

    NASA Astrophysics Data System (ADS)

    Salas, P.; Solis, M. A.; Fortes, M.

    We extend the Boson-Fermion superconductivity model to include layered systems, such as underdoped cuprate superconductors YBa2Cu3O6+x, with x ∈ (0 . 5 , 0 . 9) ranging from underdoped to optimally doped. We model cuprates as a boson-fermion quantum gas mixture immersed in a layered structure, generated via a Dirac comb potential applied in one direction while the particles move freely in the other two directions. The optimum parameters of the system, which are the impenetrability of the planes and the paired fermion fraction, are obtained by minimizing the Helmholtz free energy and setting the experimental critical temperature Tc. Using this optimized scheme, we are able to predict the following thermodynamic properties of cuprates as a function of temperature: the entropy; the Helmholtz free energy; the electronic specific heat and the total specific heat for different doping values. Furthermore, we determinate the behavior of the jump height in the electronic specific heat, the normal electronic specific heat coefficient γ (Tc) , the quadratic α and cubic β terms of the specific heat for low temperatures, the ground state energy and the mass anisotropy as a function of doping. Comparison to experimental values reported is analyzed. We aknowledge the support from Grants UNAM-DGAPA-PAPIIT IN-111613 and CONACYT 221030, Mexico.

  20. Cyclic fatty esters: synthesis, characterization, and lipolysis of isomeric triglycerides of 9-(6-propyl-3-cyclohexenyl)-(Z)8-nonenoic acid.

    PubMed

    Awl, R A; Frankel, E N; Brooks, D D; Weisleder, D

    1986-08-01

    Triglycerides of a model cyclic fatty acid (CFA) 9-(6-propyl-3-cyclohexenyl)-(Z)8-nonenoic acid (Ia) were synthesized for biological and toxicity evaluations. The monoacid triglyceride II (CyCyCy) was interesterified with triolein (OOO) to obtain mixtures of diacid triglycerides: III (OOCy), IV (OCyO), V (OCyCy), and VI (CyOCy). The interesterification mixtures were separated by preparative HPLC into two 'critical pairs' of isomeric triglycerides. Triglycerides III-VI were synthesized and a 13C-NMR method was developed to estimate 'critical pairs'. CFA-triglycerides were characterized by IR, NMR, HPLC and capillary GLC, and their relative rates of hydrolysis by lipase were compared. Although tricyclin (II) was completely resistant to lipolysis, triglycerides III and VI hydrolyzed significantly slower than triolein, and the 'critical pairs' hydrolyzed as readily as triolein. Therefore, partial CFA-triglycerides formed in heat-abused fats can undergo lipolysis and likely be absorbed like normal dietary fats. PMID:3757149

  1. Structure Revision of (22E)-Ergosta-7,22-diene-3β,5α,6β,9α,14α- pentol from the Spores of the Medicinal Mushroom Ganoderma lucidum.

    PubMed

    Yaoita, Yasunori; Machida, Koichi

    2016-02-01

    Careful reexamination of the published ¹H and ¹³C NMR spectral data of (22E)-ergosta-7,22-diene-3β,5α,6β,9α,14α-pentol (1), isolated from the spores of the medicinal mushroom Ganoderma lucidum, indicates that, in reality, the compound is (22E)-ergosta-7,22-diene-3β,5α,6β,9α,14β-pentol (5). PMID:27032196

  2. 40 CFR 721.10078 - Butanamide, 2-[(2-methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxo-, 4-[(17-substituted-3,6,9...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Butanamide, 2- -N-(2-methoxyphenyl)-3-oxo-, 4- phenyl derivs., hydrochlorides (generic). 721.10078 Section 721.10078 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses...

  3. 40 CFR 721.10078 - Butanamide, 2-[(2-methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxo-, 4-[(17-substituted-3,6,9...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Butanamide, 2- -N-(2-methoxyphenyl)-3-oxo-, 4- phenyl derivs., hydrochlorides (generic). 721.10078 Section 721.10078 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses...

  4. 40 CFR 721.10078 - Butanamide, 2-[(2-methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxo-, 4-[(17-substituted-3,6,9...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Butanamide, 2- -N-(2-methoxyphenyl)-3-oxo-, 4- phenyl derivs., hydrochlorides (generic). 721.10078 Section 721.10078 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses...

  5. 40 CFR 721.10078 - Butanamide, 2-[(2-methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxo-, 4-[(17-substituted-3,6,9...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 31 2011-07-01 2011-07-01 false Butanamide, 2- -N-(2-methoxyphenyl)-3-oxo-, 4- phenyl derivs., hydrochlorides (generic). 721.10078 Section 721.10078 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses...

  6. 40 CFR 721.10078 - Butanamide, 2-[(2-methoxy-4-nitrophenyl)azo]-N-(2-methoxyphenyl)-3-oxo-, 4-[(17-substituted-3,6,9...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Butanamide, 2- -N-(2-methoxyphenyl)-3-oxo-, 4- phenyl derivs., hydrochlorides (generic). 721.10078 Section 721.10078 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses...

  7. Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity.

    PubMed

    Carta, Davide; Bortolozzi, Roberta; Hamel, Ernest; Basso, Giuseppe; Moro, Stefano; Viola, Giampietro; Ferlin, Maria Grazia

    2015-10-22

    A series of chemically modified 7-phenylpyrrolo[3,2-f]quinolinones was synthesized and evaluated as anticancer agents. Among them, the most cytotoxic (subnanomolar GI50 values) amidic derivative 5f was shown to act as an inhibitor of tubulin polymerization (IC50, 0.99 μM) by binding to the colchicine site with high affinity. Moreover, 5f induced cell cycle arrest in the G2/M phase of the cell cycle in a concentration dependent manner, followed by caspase-dependent apoptotic cell death. Compound 5f also showed lower toxicity in nontumoral cells, suggesting selectivity toward cancer cells. Additional experiments revealed that 5f inhibited the enzymatic activity of multiple kinases, including AURKA, FLT3, GSK3A, MAP3K, MEK, RSK2, RSK4, PLK4, ULK1, and JAK1. Computational studies showed that 5f can be properly accommodated in the colchicine binding site of tubulin as well as in the ATP binding clefts of all examined kinases. Our data indicate that the excellent antiproliferative profile of 5f may be derived from its interactions with multiple cellular targets. PMID:26418966

  8. Coupled Nd-142, Nd-143 and Hf-176 Isotopic Data from 3.6-3.9 Ga Rocks: New Constraints on the Timing of Early Terrestrial Chemical Reservoirs

    NASA Technical Reports Server (NTRS)

    Bennett, Vickie C.; Brandon, alan D.; Hiess, Joe; Nutman, Allen P.

    2007-01-01

    Increasingly precise data from a range of isotopic decay schemes, including now extinct parent isotopes, from samples of the Earth, Mars, Moon and meteorites are rapidly revising our views of early planetary differentiation. Recognising Nd-142 isotopic variations in terrestrial rocks (which can only arise from events occurring during the lifetime of now extinct Sm-146 [t(sub 1/2)=103 myr]) has been an on-going quest starting with Harper and Jacobsen. The significance of Nd-142 variations is that they unequivocally reflect early silicate differentiation processes operating in the first 500 myr of Earth history, the key time period between accretion and the beginning of the rock record. The recent establishment of the existence of Nd-142 variations in ancient Earth materials has opened a new range of questions including, how widespread is the evidence of early differentiation, how do Nd-142 compositions vary with time, rock type and geographic setting, and, combined with other types of isotopic and geochemical data, what can Nd-142 isotopic variations reveal about the timing and mechanisms of early terrestrial differentiation? To explore these questions we are determining high precision Nd-142, Nd-143 and Hf-176 isotopic compositions from the oldest well preserved (3.63- 3.87 Ga), rock suites from the extensive early Archean terranes of southwest Greenland and western Australia.

  9. Crystal structure, NMR study, dielectric relaxation and AC conductivity of a new compound [Cd3(SCN)2Br6(C2H9N2)2]n

    NASA Astrophysics Data System (ADS)

    Saidi, K.; Kamoun, S.; Ayedi, H. Ferid; Arous, M.

    2013-11-01

    The crystal structure, the 13C NMR spectroscopy and the complex impedance have been carried out on [Cd3(SCN)2Br6(C2H9N2)2]n. Crystal structure shows a 2D polymeric network built up of two crystallographically independent cadmium atoms with two different octahedral coordinations. This compound exhibits a phase transition at (T=355±2 K) which has been characterized by differential scanning calorimetry (DSC), X-rays powder diffraction, AC conductivity and dielectric measurements. Examination of 13C CP/MAS line shapes shows indirect spin-spin coupling (14N and 13C) with a dipolar coupling constant of 1339 Hz. The AC conductivity of this compound has been carried out in the temperature range 325-376 K and the frequency range from 10-2 Hz to 10 MHz. The impedance data were well fitted to two equivalent electrical circuits. The results of the modulus study reveal the presence of two distinct relaxation processes. One, at low frequency side, is thermally activated due to the ionic conduction of the crystal and the other, at higher frequency side, gradually disappears when temperature reaches 355 K which is attributed to the localized dipoles in the crystal. Moreover, the temperature dependence of DC-conductivity in both phases follows the Arrhenius law and the frequency dependence of σ(ω,T) follows Jonscher's universal law. The near values of activation energies obtained from the conductivity data and impedance confirm that the transport is through the ion hopping mechanism.

  10. (NH{sub 3}CH{sub 2}CH{sub 2}NH{sub 3})B{sub 6}O{sub 9}(OH){sub 2}: Synthesis and crystal structure of a novel layered borate templated by ethylenediamine

    SciTech Connect

    Li Min; Chang Jiazhong; Wang Zhenling; Shi Hengzhen . E-mail: hzshi@zknu.edu.cn

    2006-11-15

    A novel intercalated borate compound (NH{sub 3}CH{sub 2}CH{sub 2}NH{sub 3})B{sub 6}O{sub 9}(OH){sub 2}, has been solvothermally synthesized, and structurally characterized by single crystal X-ray diffraction. Compound crystallizes in the monoclinic, space group P2(1)/c, a=8.6200(17)A, b=15.656(3)A, c=8.8386(18)A, {beta}=93.32(3){sup o}, V=1190.8(4)A{sup 3}, Z=4. Its oxoborate structure is built up from 1-D polyborate chains with 3, 11-membered boron rings bonded diamine molecules through electrostatic attraction and hydrogen bond interactions to construct 2-D layered compound. Other characterizations by IR, element analysis, thermal analysis and specific surface area are also discussed.

  11. Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols.

    PubMed

    Iyer, Malliga R; Rothman, Richard B; Dersch, Christina M; Jacobson, Arthur E; Rice, Kenner C

    2015-03-01

    Racemic N-substituted -1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols containing cis-4a-aralkyl groups were explored as probes for opioid receptors. Specifically cis-4a-phenylpropyl, -phenylbutyl, and-phenylpentyl groups coupled with widely varied substituents on the nitrogen atom were synthesized and their pharmacological profiles at opioid receptors examined. The study yielded compounds with good affinity and moderate to potent antagonist activity at the μ- and δ-opioid receptors, and agonist activity at the κ-opioid receptor. An N-allyl substituent in the C4a phenylpropyl series induced 6-fold higher affinity at δ-than μ-receptors, while an N-CPM substituent in the C4a (CH2)3Ph series led to a compound with high δ-affinity and potent δ-antagonist activity. PMID:25599950

  12. NTP Carcinogenesis Bioassay of Diallyl Phthalate (CAS No. 131-17-9) in B6C3F1 Mice (Gavage Study).

    PubMed

    1983-04-01

    , hyperplasia, and inflammatory lesions of the forestomach were observed in diallyl phthalate-dosed mice of both sexes in a dose-related manner. Papillomas of the forestomach were observed in 0%, 2%, and 4% of the control, low-dose, and high-dose mice of both sexes. The recent historical incidence of this tumor in gavage control mice from both the performing laboratory and other laboratories within the Bioassay Program was less than 1%. Forestomach hyperplasia was diagnosed in 0%, 15%, and 18%, and in 8%, 2%, and 29% of the control, low-dose, and high-dose male and female mice, respectively; chronic inflammation of the forestomach was diagnosed in 0%, 9%, and 16% and in 4%, 2%, and 18% of the control, low-dose, and high-dose male and female mice, respectively. Because of the numerical elevation of the forestomach papillomas in the high-dose mice of both sexes, the concomitant observation of dose related forestomach hyperplasia, and the rarity of this tumor in corn oil (gavage) control B6C3F1 mice, the development of squamous cell papillomas of the forestomach may have been related to diallyl phthalate administration. Under the conditions of this bioassay, the development of chronic inflammation and hyperplasia of the forestomach in both male and female B6C3F1 mice was considered to be related to the administration of diallyl phthalate. The development of squamous cell papillomas of the forestomach may also have been related to chemical administration, but the available data are insufficient to indicate a clear cause and effect relationship. An increase in the incidence of male mice with lymphomas was observed, but this increase was considered only to be equivocally related to diallyl phthalate administration. The results of this bioassay, therefore, do not indicate that diallyl phthalate is carcinogenic in B6C3F1 mice, although a maximum tolerated dose may not have been achieved. A carcinogenicity study by the National Toxicology Program of diallyl phthalate in male and female

  13. Analysis of 133 meioses places the genes for nevoid basal cell carcinoma (gorlin) syndrome and fanconi anemia group C in a 2.6-cM interval and contributes to the fine map of 9q22.3

    SciTech Connect

    Farndon, P.A.; Hardy, C.; Kilpatrick, M.W.

    1994-09-15

    Four disease genes (NBCCS, ESS1, XPAC, FACC) map to 9q22.3-q31. A fine map of this region was produced by linkage and haplotype analysis using 12 DNA markers. The gene for nevoid basal cell carcinoma syndrome (NBCCS, Gorlin) has an important role in congenital malformations and carcinogenesis. Phase-known recombinants in a study of 133 meioses place NBCCS between (D9S12/D9S151) and D9S176. Haplotype analysis in a two-generation family suggests that NBCCS lies in a smaller interval of 2.6 cM centromeric to D9S287. These flanking markers will be useful clinically for gene tracking. Recombinants also map FACC (Fanconi anemia, group C) to the same region, between (D9S12/D9S151) and D9S287. The recombination rate between (D9S12/D9S151) and D9S53 in males is 8.3% and 13.2% in females, giving a sex-specific male:female ratio of 1:1.6 and a sex-averaged map distance of 10.4 cM. No double recombinants were detected, in agreement with the apparently complete level of interference predicted from the male chiasmata map. 19 refs., 2 figs., 1 tab.

  14. Improved measurement of the hyperfine structure of the laser cooling level 4f^{12}(^3H_6)5d_{5/2}6s^2 (J=9/2) in {}^{169}_{ 69}{{Tm}}

    NASA Astrophysics Data System (ADS)

    Fedorov, S. A.; Vishnyakova, G. A.; Kalganova, E. S.; Sukachev, D. D.; Golovizin, A. A.; Tregubov, D. O.; Khabarova, K. Yu.; Akimov, A. V.; Kolachevsky, N. N.; Sorokin, V. N.

    2015-12-01

    We report on an improved measurement of the hyperfine constant of the 4f^{12}(^3 H_6)5d_{5/2}6s^2 (J=9/2) excited state of {}^{169}_{ 69}{{Tm}} which is involved in the second-stage laser cooling of Tm. To measure the absolute value of the hyperfine splitting interval, we used Doppler-free frequency modulation saturated absorption spectroscopy of Tm atoms in a vapor cell. The sign of the hyperfine constant was determined independently by spectroscopy of laser-cooled Tm atoms. The hyperfine constant of the level was determined to be A_J=-422.112(32) {MHz} from the energy difference between the two hyperfine sublevels, -2110.56(16) {MHz}. In relation to the saturated absorption measurement, we quantitatively treat contributions of various mechanisms to the line broadening and shift. We consider power broadening in the case when Zeeman sublevels of atomic levels are taken into account. We also discuss the line broadening due to frequency modulation and relative intensities of transitions in saturated absorption experiments.

  15. Two fatty acid desaturases, STEAROYL-ACYL CARRIER PROTEIN Δ9-DESATURASE6 and FATTY ACID DESATURASE3, are involved in drought and hypoxia stress signaling in Arabidopsis crown galls.

    PubMed

    Klinkenberg, Joern; Faist, Hanna; Saupe, Stefanie; Lambertz, Sophie; Krischke, Markus; Stingl, Nadja; Fekete, Agnes; Mueller, Martin J; Feussner, Ivo; Hedrich, Rainer; Deeken, Rosalia

    2014-02-01

    Agrobacterium tumefaciens-derived crown galls of Arabidopsis (Arabidopsis thaliana) contain elevated levels of unsaturated fatty acids and strongly express two fatty acid desaturase genes, ω3 FATTY ACID DESATURASE3 (FAD3) and STEAROYL-ACYL CARRIER PROTEIN Δ9-DESATURASE6 (SAD6). The fad3-2 mutant with impaired α-linolenic acid synthesis developed significantly smaller crown galls under normal, but not under high, relative humidity. This strongly suggests that FAD3 plays a role in increasing drought stress tolerance of crown galls. SAD6 is a member of the SAD family of as yet unknown function. Expression of the SAD6 gene is limited to hypoxia, a physiological condition found in crown galls. As no sad6 mutant exists and to link the function of SAD6 with fatty acid desaturation in crown galls, the lipid pattern was analyzed of plants with constitutive SAD6 overexpression (SAD6-OE). SAD6-OE plants contained lower stearic acid and higher oleic acid levels, which upon reduction of SAD6 overexpression by RNA interference (SAD6-OE-RNAi) regained wild-type-like levels. The development of crown galls was not affected either in SAD6-OE or SAD6-OE-RNAi or by RNA interference in crown galls. Since biochemical analysis of SAD6 in yeast (Saccharomyces cerevisiae) and Escherichia coli failed, SAD6 was ectopically expressed in the background of the well-known suppressor of salicylic acid-insensitive2 (ssi2-2) mutant to confirm the desaturase function of SAD6. All known ssi2-2 phenotypes were rescued, including the high stearic acid level. Thus, our findings suggest that SAD6 functions as a Δ9-desaturase, and together with FAD3 it increases the levels of unsaturated fatty acids in crown galls under hypoxia and drought stress conditions. PMID:24368335

  16. Corner sharing tetrahedral network in Co(3)(HAT)[N(CN)(2)](6)(OH(2))(2) (HAT = 1,4,5,8,9,12-hexaazatriphenylene).

    PubMed

    Marshall, Shireen R; Rheingold, Arnold L; Dawe, Louise N; Shum, William W; Kitamura, Chitoshi; Miller, Joel S

    2002-07-15

    We report a trinuclear Co(II) complex containing bridging dicyanamides and a tris-chelated HAT, which possesses approximately 37% void space. The magnetic exchange pathways appear in the structure as a corner sharing tetrahedral network. The compound crystallizes in the monoclinic space group P2(1)/c [a = 13.655(3) A, b = 15.189(3) A, c = 22.367(4) A, beta = 114.100(2) degrees, V = 4234.5(14) A(3), Z = 4, R(F(o)) = 0.0823]. The magnetic data were fit to an S = 3/2 model for systems dominated by zero-field splitting effects with g = 2.01 and D = 38.9 cm(-1). PMID:12099860

  17. 9 CFR 91.6 - Goats.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... exported if it is a scrapie-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54... IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS INSPECTION AND HANDLING OF LIVESTOCK...

  18. 9 CFR 91.6 - Goats.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... exported if it is a scrapie-positive animal or an exposed animal, as defined in 9 CFR parts 54 and 79, or if it has ever been in an infected flock, source flock, or trace flock, as defined in 9 CFR parts 54... IMPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS INSPECTION AND HANDLING OF LIVESTOCK...

  19. Comparison of the metabolism of [1,2,6,7-3H(N)]cholesteryl oleate, cholesteryl [9,10-3H]oleate, and cholesteryl [1-14C]oleate labeled lipoproteins in the rat.

    PubMed

    Terpstra, A H

    1994-04-01

    The intravascular metabolism of sterol labeled [1,2,6,7-3H(N)]cholesteryl oleate and acyl labeled cholesteryl [9,10-3H]oleate and cholesteryl [1-14C]oleate was compared in the rat, an animal species without plasma cholesteryl ester transfer activity (CETA). In a first series of studies, the metabolism of sterol labeled [1,2,6,7-3H(N)]cholesteryl oleate and acyl labeled cholesteryl [1-14C]oleate was compared, and the two tracers had identical plasma clearance rates when incorporated into human low density lipoproteins (LDL). The 3H sterol labeled cholesteryl ester (CE), however, had a plasma clearance rate lower than the 14C acyl labeled CE when incorporated into rat alpha- and beta-migrating LDL and human or rat high density lipoproteins (HDL). Unesterified 3H cholesterol reappeared in the plasma whereas the 14C radioactivity in the plasma remained associated with the CE. In a second set of studies, LDL and HDL were radiolabeled with cholesteryl [9,10-3H]oleate and cholesteryl [1-14C]oleate. Large amounts of 3H radioactivity that were dialyzable and not associated with the lipoprotein CE reappeared in the plasma during the kinetic studies. The two tracers had identical plasma disappearance rates when the plasma samples were dialyzed. The results of these studies indicate that the nature of the tracer used to trace lipoprotein CE can affect the estimated kinetic parameters of plasma CE. PMID:8060380

  20. Neutron powder diffraction study of Ba3ZnRu2-xIrxO9 (x = 0, 1, 2) with 6H-type perovskite structure

    NASA Astrophysics Data System (ADS)

    Beran, P.; Ivanov, S. A.; Nordblad, P.; Middey, S.; Nag, A.; Sarma, D. D.; Ray, S.; Mathieu, R.

    2015-12-01

    The triple perovskites Ba3ZnRu2-xIrxO9 with x = 0, 1, and 2 are insulating compounds in which Ru(Ir) cations form a dimer state. Polycrystalline samples of these materials were studied using neutron powder diffraction (NPD) at 10 and 295 K. No structural transition nor evidence of long range magnetic order was observed within the investigated temperature range. The results from structural refinements of the NPD data and its polyhedral analysis are presented, and discussed as a function of Ru/Ir content.

  1. 9-Amino­acridinium bis­(pyridine-2,6-dicarboxyl­ato-κ3 O 2,N,O 6)ferrate(III) tetra­hydrate

    PubMed Central

    Mirzaei, Masoud; Eshtiagh-Hosseini, Hossein; Eydizadeh, Ehsan; Yousefi, Zakieh; Molčanov, Krešimir

    2012-01-01

    The asymmetric unit of the title compound, (C13H11N2)[Fe(C7H3NO4)2]·4H2O, contains a 9-amino­acridinium cation, one anionic complex and four uncoordinated water mol­ecules. In the anionic complex, the FeIII ion is six-coordinated by two almost perpendicular [dihedral angle = 88.78 (7)°] pyridine-2,6-dicarboxyl­ate ligands in a distorted octa­hedral geometry. In the crystal, anions are connected into chains along [10-1] by weak C—H⋯O inter­actions, which create ten-membered hydrogen-bonded R 2 2(10) rings. These chains are linked by three-membered water clusters. The final three-dimensional network is constructed by numerous inter­molecular O—H⋯O and N—H⋯O inter­actions. PMID:22719319

  2. The effects of H2S on the activities of CYP2B6, CYP2D6, CYP3A4, CYP2C19 and CYP2C9 in vivo in rat.

    PubMed

    Wang, Xianqin; Han, Anyue; Wen, Congcong; Chen, Mengchun; Chen, Xinxin; Yang, Xuezhi; Ma, Jianshe; Lin, Guanyang

    2013-01-01

    Hydrogen sulfide (H2S) is a colorless, flammable, extremely hazardous gas with a "rotten egg" smell. The human body produces small amounts of H2S and uses it as a signaling molecule. The cocktail method was used to evaluate the influence of H2S on the activities of CYP450 in rats, which were reflected by the changes of pharmacokinetic parameters of five specific probe drugs: bupropion, metroprolol, midazolam, omeprazole and tolbutamide, respectively. The rats were randomly divided into two groups, control group and H2S group. The H2S group rats were given 5 mg/kg NaHS by oral administration once a day for seven days. The mixture of five probes was given to rats through oral administration and the blood samples were obtained at a series of time-points through the caudal vein. The concentrations of probe drugs in rat plasma were measured by LC-MS. In comparing the H2S group with the control group, there was a statistically pharmacokinetics difference for midazolam and tolbutamide; the area under the plasma concentration-time curve (AUC) was decreased for midazolam (p < 0.05) and increased for tolbutamide (p < 0.05); while there was no statistical pharmacokinetics difference for bupropion, metroprolol and omeprazole. H2S could not influence the activities of CYP2B6, CYP2D6 and CYP2C19 in rats, while H2S could induce the activity of CYP3A4 and inhibit the activity of CYP2C9 in rats. PMID:24336065

  3. The Effects of H2S on the Activities of CYP2B6, CYP2D6, CYP3A4, CYP2C19 and CYP2C9 in Vivo in Rat

    PubMed Central

    Wang, Xianqin; Han, Anyue; Wen, Congcong; Chen, Mengchun; Chen, Xinxin; Yang, Xuezhi; Ma, Jianshe; Lin, Guanyang

    2013-01-01

    Hydrogen sulfide (H2S) is a colorless, flammable, extremely hazardous gas with a “rotten egg” smell. The human body produces small amounts of H2S and uses it as a signaling molecule. The cocktail method was used to evaluate the influence of H2S on the activities of CYP450 in rats, which were reflected by the changes of pharmacokinetic parameters of five specific probe drugs: bupropion, metroprolol, midazolam, omeprazole and tolbutamide, respectively. The rats were randomly divided into two groups, control group and H2S group. The H2S group rats were given 5 mg/kg NaHS by oral administration once a day for seven days. The mixture of five probes was given to rats through oral administration and the blood samples were obtained at a series of time-points through the caudal vein. The concentrations of probe drugs in rat plasma were measured by LC-MS. In comparing the H2S group with the control group, there was a statistically pharmacokinetics difference for midazolam and tolbutamide; the area under the plasma concentration-time curve (AUC) was decreased for midazolam (p < 0.05) and increased for tolbutamide (p < 0.05); while there was no statistical pharmacokinetics difference for bupropion, metroprolol and omeprazole. H2S could not influence the activities of CYP2B6, CYP2D6 and CYP2C19 in rats, while H2S could induce the activity of CYP3A4 and inhibit the activity of CYP2C9 in rats. PMID:24336065

  4. C,O-dialkylation of Meldrum's acid: synthesis and reactivity of 1,3,7,7-tetramethyl-4H,10H-6,8,9-trioxa-2-thiabenz[f]azulen-5-one.

    PubMed

    Snyder, Chad A; Selegue, John P; Dosunmu, Eniolami; Tice, Nathan C; Parkin, Sean

    2003-09-19

    Reaction of Meldrum's acid with 3,4-bis(chloromethyl)-2,5-dimethylthiophene (1) or 3,4-bis(bromomethyl)-2,5-dimethylthiophene (2) produces the kinetically favored C,O-dialkylation product, 1,3,7,7-tetramethyl-4H,10H-6,8,9-trioxa-2-thiabenz[f]azulen-5-one (4). Recrystallization of 4 from refluxing methanol results in the methanolysis product 5-(4-methoxymethyl-2,5-dimethylthiophen-3-ylmethyl)-2,2-dimethyl[1,3]dioxane-4,6-dione (5). Attempts to isomerize 4 to the thermodynamically favored C,C-dialkylation product, 1,3-dimethyl-5,6-dihydro-4H-cyclopenta[c]thiophene(2-spiro-5)2,2-dimethyl-4,6-dione (8), result in the formation of 1,3-dimethyl-7,8-dihydro-4H-thieno[3,4-c]oxepin-6-one (6). The transformation occurs via a retro-Diels-Alder elimination of acetone followed by hydrolysis and decarboxylation of the resulting ketene. The ketene is trapped by tert-butyl alcohol, furnishing 1,3-dimethyl-6-oxo-7,8-dihydro-4H,6H-thieno[3,4-c]oxepine-7-carboxylic acid tert-butyl ester (7). All compounds are characterized spectroscopically as well as by X-ray crystallography of products 4-7. PMID:12968900

  5. 31 CFR 6.9 - Net worth exhibit.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Net worth exhibit. 6.9 Section 6.9... EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 6.9 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  6. 31 CFR 6.9 - Net worth exhibit.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Net worth exhibit. 6.9 Section 6.9... EQUAL ACCESS TO JUSTICE ACT Information Required From Applicants § 6.9 Net worth exhibit. (a) Each... application a detailed exhibit showing the net worth of the applicant and any affiliates (as defined in §...

  7. 15 CFR 9.6 - Termination of participation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Termination of participation. 9.6 Section 9.6 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY LABELING PROGRAM FOR HOUSEHOLD APPLIANCES AND EQUIPMENT TO EFFECT ENERGY CONSERVATION § 9.6 Termination...

  8. 47 CFR 6.9 - Information pass through.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Information pass through. 6.9 Section 6.9... Entities Do? § 6.9 Information pass through. Telecommunications equipment and customer premises equipment..., formats or other information necessary to provide telecommunications in an accessible format, if...

  9. 15 CFR 9.6 - Termination of participation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 15 Commerce and Foreign Trade 1 2012-01-01 2012-01-01 false Termination of participation. 9.6 Section 9.6 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY LABELING PROGRAM FOR HOUSEHOLD APPLIANCES AND EQUIPMENT TO EFFECT ENERGY CONSERVATION § 9.6 Termination of participation. (a) The Department of...

  10. 37 CFR 202.6-202.9 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false 202.6-202.9 Section 202.6-202.9 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES PREREGISTRATION AND REGISTRATION OF CLAIMS TO COPYRIGHT §§ 202.6-202.9...

  11. 37 CFR 202.6-202.9 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2012-07-01 2012-07-01 false 202.6-202.9 Section 202.6-202.9 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES PREREGISTRATION AND REGISTRATION OF CLAIMS TO COPYRIGHT §§ 202.6-202.9...

  12. 37 CFR 202.6-202.9 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2014-07-01 2014-07-01 false 202.6-202.9 Section 202.6-202.9 Patents, Trademarks, and Copyrights U.S. COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES PREREGISTRATION AND REGISTRATION OF CLAIMS TO COPYRIGHT §§ 202.6-202.9...

  13. 37 CFR 202.6-202.9 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false 202.6-202.9 Section 202.6-202.9 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES PREREGISTRATION AND REGISTRATION OF CLAIMS TO COPYRIGHT §§ 202.6-202.9...

  14. 37 CFR 202.6-202.9 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2013-07-01 2013-07-01 false 202.6-202.9 Section 202.6-202.9 Patents, Trademarks, and Copyrights COPYRIGHT OFFICE, LIBRARY OF CONGRESS COPYRIGHT OFFICE AND PROCEDURES PREREGISTRATION AND REGISTRATION OF CLAIMS TO COPYRIGHT §§ 202.6-202.9...

  15. Study of the formation of the apatite-type phases La9.33+x(SiO4)6O2+3x/2 synthesized from a lanthanum oxycarbonate La2O2CO3

    NASA Astrophysics Data System (ADS)

    Pons, A.; Jouin, J.; Béchade, E.; Julien, I.; Masson, O.; Geffroy, P. M.; Mayet, R.; Thomas, P.; Fukuda, K.; Kagomiya, I.

    2014-12-01

    Lanthanum silicated apatites with nominal composition La9.33+x(SiO4)6O2+3x/2 (-0.2 < x < 0.27) have been successfully synthesized by solid state reaction using a new reagent La2O2CO3 and amorphous SiO2 precursors. The formation mechanism of La2O2CO3 reagent, which cannot be purchased, has been followed by in-situ temperature depend XRD of La2O3 under CO2 atmosphere. The stability of this reagent during the synthesis step allowed to limit the formation of secondary phase La2Si2O7 and made the weighting of the reagent easier. High purity powders could be synthesized at the temperature of 1400 °C. Dense pellets (more than 98.5%) were obtained by isostatic pressing of powders calcined at 1200 °C and then sintered at 1550 °C. Traces of La2SiO5 secondary phase present in synthesized powder disappeared after densification and pure oxyapatite materials were obtained for all the compositions. Electrical measurements confirmed that conductivity behaviors of the sintered pellets were dependent to the oxygen over-stoichiometry. Indeed, a relatively high conductivity of 1 × 10-2 S cm-1 was exhibited at 800 °C for the nominal composition La9.60(SiO4)6O2.405 with low activation energy around 0.79 eV. The ionic conductivity properties were comparable with that of the earlier obtained materials.

  16. Foxp3⁺ regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice.

    PubMed

    Blankenhaus, Birte; Reitz, Martina; Brenz, Yannick; Eschbach, Marie-Luise; Hartmann, Wiebke; Haben, Irma; Sparwasser, Tim; Huehn, Jochen; Kühl, Anja; Feyerabend, Thorsten B; Rodewald, Hans-Reimer; Breloer, Minka

    2014-02-01

    Accumulating evidence suggests that IL-9-mediated immunity plays a fundamental role in control of intestinal nematode infection. Here we report a different impact of Foxp3⁺ regulatory T cells (Treg) in nematode-induced evasion of IL-9-mediated immunity in BALB/c and C57BL/6 mice. Infection with Strongyloides ratti induced Treg expansion with similar kinetics and phenotype in both strains. Strikingly, Treg depletion reduced parasite burden selectively in BALB/c but not in C57BL/6 mice. Treg function was apparent in both strains as Treg depletion increased nematode-specific humoral and cellular Th2 response in BALB/c and C57BL/6 mice to the same extent. Improved resistance in Treg-depleted BALB/c mice was accompanied by increased production of IL-9 and accelerated degranulation of mast cells. In contrast, IL-9 production was not significantly elevated and kinetics of mast cell degranulation were unaffected by Treg depletion in C57BL/6 mice. By in vivo neutralization, we demonstrate that increased IL-9 production during the first days of infection caused accelerated mast cell degranulation and rapid expulsion of S. ratti adults from the small intestine of Treg-depleted BALB/c mice. In genetically mast cell-deficient (Cpa3-Cre) BALB/c mice, Treg depletion still resulted in increased IL-9 production but resistance to S. ratti infection was lost, suggesting that IL-9-driven mast cell activation mediated accelerated expulsion of S. ratti in Treg-depleted BALB/c mice. This IL-9-driven mast cell degranulation is a central mechanism of S. ratti expulsion in both, BALB/c and C57BL/6 mice, because IL-9 injection reduced and IL-9 neutralization increased parasite burden in the presence of Treg in both strains. Therefore our results suggest that Foxp3⁺ Treg suppress sufficient IL-9 production for subsequent mast cell degranulation during S. ratti infection in a non-redundant manner in BALB/c mice, whereas additional regulatory pathways are functional in Treg-depleted C57BL/6

  17. 3D characterization by tomography of beta Al9Fe2Si2 phase precipitation in a Al6.5Si1Fe alloy

    NASA Astrophysics Data System (ADS)

    Ferdian, D.; Salvo, L.; Lacaze, J.; Tenailleau, C.; Duployer, B.; Malard, B.

    2016-03-01

    The microstructure evolution of beta phase during solidification of a synthetic Al6.5Si1Fe (wt.%) alloy has been investigated by in-situ synchrotron micro-tomography and post-mortem tomography. In-situ solidification was observed at a constant cooling rate of 10°C min-1, from above the alloy's liquidus with the melt at 618°C down to 575°C which is just above the (Al)-Si-beta invariant eutectic reaction. Primary (Al) dendrites nucleated at 608°C, followed by the formation of beta-Al9Fe2Si2 phase starting at 593°C. After a rapid growth stage until 587°C as thin plates, beta phase continued to grow at a paced rate. Thickening of the plates was also evaluated and it was observed that the decrease in the lateral growth rate of the plates did not lead to an increase of their thickening rate. It was noted that the interconnectivity between beta precipitates increased as the solidification progressed. While nucleation of beta phase has previously been reported to occur on the alumina scale formed at the outer surface of the material, it is shown from post mortem tomography that bulk nucleation can occur as well.

  18. 9 CFR 351.6 - Official number.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Procedure for Obtaining Service: Administration of Program § 351.6 Official number. The Administrator will assign a certified technical animal fat... to identify all certified technical animal fat prepared or stored by the plant....

  19. 9 CFR 351.6 - Official number.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Procedure for Obtaining Service: Administration of Program § 351.6 Official number. The Administrator will assign a certified technical animal fat... to identify all certified technical animal fat prepared or stored by the plant....

  20. 9 CFR 351.6 - Official number.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Procedure for Obtaining Service: Administration of Program § 351.6 Official number. The Administrator will assign a certified technical animal fat... to identify all certified technical animal fat prepared or stored by the plant....

  1. 9 CFR 351.6 - Official number.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Procedure for Obtaining Service: Administration of Program § 351.6 Official number. The Administrator will assign a certified technical animal fat... to identify all certified technical animal fat prepared or stored by the plant....

  2. 9 CFR 351.6 - Official number.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... CERTIFICATION CERTIFICATION OF TECHNICAL ANIMAL FATS FOR EXPORT Procedure for Obtaining Service: Administration of Program § 351.6 Official number. The Administrator will assign a certified technical animal fat... to identify all certified technical animal fat prepared or stored by the plant....

  3. 36 CFR 6.9 - Permits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... waste treatment plant or septic system, domestic sewage, petroleum, including used crankcase oil from a...), the Endangered Species Act (16 U.S.C. 1531-1543), and E.O. 11988, Floodplain Management (3 CFR, 1978 Comp., p. 117), and E.O. 11990, Wetland Protection (3 CFR, 1978 Comp., 121). (c) The Regional...

  4. MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: a novel dual-acting mu- and kappa-opioid agonist with potent antinociceptive and weak rewarding effects in mice.

    PubMed

    Matsumoto, Kenjiro; Takayama, Hiromitsu; Narita, Minoru; Nakamura, Atsushi; Suzuki, Masami; Suzuki, Tsutomu; Murayama, Toshihiko; Wongseripipatana, Sumphan; Misawa, Kaori; Kitajima, Mariko; Tashima, Kimihito; Horie, Syunji

    2008-08-01

    Mitragynine is a major indole alkaloid isolated from the Thai medicinal plant Mitragyna speciosa that has opium-like properties, although its chemical structure is quite different from that of morphine. We attempted to develop novel analgesics derived from mitragynine, and thus synthesized the ethylene glycol-bridged and C10-fluorinated derivative of mitragynine, MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate]. We hypothesized that a dual-acting mu- and kappa-opioid agonist could produce potent antinociceptive effects with fewer rewarding effects compared with mu agonists. In this study, MGM-9 exhibited high affinity for mu- and kappa-opioid receptors with Ki values of 7.3 and 18 nM, respectively. MGM-9 showed a potent opioid agonistic effect, and its effects were meditated by mu- and kappa-opioid receptor mechanisms in in vitro assays. Subcutaneous and oral administration of MGM-9 produced potent antinociceptive effects in mouse tail-flick, hot-plate, and writhing tests. When administered orally, the antinociceptive effect of MGM-9 was seven to 22 times more potent than that of morphine. The antinociceptive effects of MGM-9 were mediated by both mu- and kappa-opioid receptors. Subcutaneous administration of MGM-9 twice daily for 5 days led to antinociceptive tolerance. In the gastrointestinal transit study, MGM-9 inhibited gastrointestinal transit, but its effect was weaker than that of morphine at equi-antinociceptive doses. Furthermore, MGM-9 induced less hyperlocomotion and fewer rewarding effects than morphine. The rewarding effect of MGM-9 was blocked by a mu antagonist and enhanced by a kappa antagonist. Taken together, the results suggest that MGM-9 is a promising novel analgesic that has a stronger antinociceptive effect and weaker adverse effects than morphine. PMID:18550129

  5. 29 CFR 9.3 - Coverage.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 1 2014-07-01 2013-07-01 true Coverage. 9.3 Section 9.3 Labor Office of the Secretary of Labor NONDISPLACEMENT OF QUALIFIED WORKERS UNDER SERVICE CONTRACTS General § 9.3 Coverage. This part applies to all service contracts and their solicitations, except those excluded by § 9.4 of this...

  6. 29 CFR 9.3 - Coverage.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 1 2013-07-01 2013-07-01 false Coverage. 9.3 Section 9.3 Labor Office of the Secretary of Labor NONDISPLACEMENT OF QUALIFIED WORKERS UNDER SERVICE CONTRACTS General § 9.3 Coverage. This part applies to all service contracts and their solicitations, except those excluded by § 9.4 of this...

  7. 9 CFR 83.6 - Testing requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... document a 2-year history of negative testing for VHS virus, can conduct testing at a sampling level to... virus can conduct testing at a sampling level to provide a 95 percent confidence level of detecting a 10... least 3 months between tests. (iii) Such facilities must be on a secure water source, and document...

  8. 9 CFR 83.6 - Testing requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... document a 2-year history of negative testing for VHS virus, can conduct testing at a sampling level to... virus can conduct testing at a sampling level to provide a 95 percent confidence level of detecting a 10... least 3 months between tests. (iii) Such facilities must be on a secure water source, and document...

  9. Pro-apoptotic effect of new quinolone 7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate on cervical cancer cell line HeLa alone/with UVA irradiation.

    PubMed

    Jantová, Soňa; Mrvová, Nataša; Hudec, Roman; Sedlák, Ján; Pánik, Miroslav; Milata, Viktor

    2016-06-01

    7- ethyl 9-ethyl-6-oxo-6,9-dihydro[1,2,5]selenadiazolo [3,4-h]quinoline-7-carboxylate (E2h) is a new synthetically prepared quinolone derivative, which in our primary study showed cytotoxic effects towards tumor cells. The aim of the present study was to examine the antiproliferative and apoptosis inducing activities of E2h towards human cervical cancer cell line HeLa with/without the presence of UVA irradiation. Further, the molecular mechanism involved in E2h-induced apoptosis in HeLa cells was investigated. Our results showed that both non-photoactivated and photoactivated E2h caused morphological changes and inhibited the cell growth of HeLa cells in a time- and dose-dependent manner. Irradiation increased the sensitivity of HeLa cells to E2h. Quinolone induced S and G2/M arrest and apoptosis in HeLa cells, as characterized by DNA fragmentation and flow cytometry. In addition, E2h elevated the level of reactive oxygen species and activated caspases 3. In conclusions, E2h alone/in combination with UVA irradiation induced apoptosis in HeLa cells through the ROS-mitochondrial/caspase 3-dependent pathway. PMID:26916084

  10. Study of magnetic transition and magnetic entropy changes of Pr0.6Sr0.4MnO3 and Pr0.6Sr0.4Mn0.9Fe0.1O3 compounds

    NASA Astrophysics Data System (ADS)

    Nasri, Abir.; Hlil, E. K.; Lehlooh, A.-F.; Ellouze, M.; Elhalouani, F.

    2016-04-01

    In the present work, we analyze the magnetic transition and magnetic entropy change \\vertΔ SM\\vert of Pr0.6Sr0.4Mn1- x Fe x O3 samples. Using Arrott plots, we report that the phase transition for Pr0.6Sr0.4MnO3 sample is of second order, while the Pr0.6Sr0.4Mn0.9Fe0.1O3 sample exhibits a first-order magnetic phase transition. From the magnetization measurements at temperature close to the Curie temperature, the magnetic entropy change, \\vertΔ SM\\vert and the Relative Cooling Power (RCP) have been estimated. The maximum of magnetic entropy change \\vertΔ S_M^{max}\\vert reaches, under an applied magnetic field of 5T, 3.58 and 3.66J/kg K for Pr0.6Sr0.4MnO3 and Pr0.6Sr0.4Mn0.9Fe0.1O3, respectively. The RCP values have been estimated to 159.37 and 223.52J/kg. For both samples, the \\vertΔ SM\\vert values evaluated using the Maxwell theory were found in accordance with those calculated by the Landau theory.

  11. Crystal structure of rac-(3aR,4S,5aR,6S,9R,10aS,10bR)-3a,5a,9-tri­methyl­tetra­deca­hydro-6,9-ep­oxy­cyclo­hepta­[e]inden-4-ol monohydrate

    PubMed Central

    Schäfer, Andreas; Golz, Christopher; Preut, Hans; Strohmann, Carsten; Hiersemann, Martin

    2015-01-01

    The title hydrate, C17H28O2·H2O, was synthesized in order to determine the relative configuration of the tetra­cyclic framework. The fused 5,6,7-tricarbocyclic core exhibits an entire cis-annulation, featuring a 1,4-cis-relation of the angular methyl groups in the six-membered ring. The oxa bridge of the ep­oxy­cyclo­heptane moiety is oriented towards the concave face of the boat-shaped mol­ecule, whereas the angular methyl groups are directed towards the convex face. The asymmetric unit of the crystal contains two nearly identical formula units, which are related via a pseudo-centre of symmetry. The structure could be solved in the space groups I-4 and I41/a. The refinement in the acentric space group, however, gave significantly better results and these are used in this paper. O—H⋯O hydrogen bonds are observed between the organic mol­ecules, between the organic mol­ecules and the water mol­ecules, and between the water mol­ecules, forming a chain along the c-axis direction. PMID:26396907

  12. Crystal structure of (1S,3R,8R,9R)-2,2-di­chloro-3,7,7-tri­methyl-10-methylenetri­cyclo­[6.4.0.01,3]dodecan-9-ol

    PubMed Central

    Benzalim, Ahmed; Auhmani, Aziz; Bimoussa, Abdoullah; Ait Itto, My Youssef; Daran, Jean-Claude; Auhmani, Abdelwahed

    2016-01-01

    The title compound, C16H24Cl2O, was synthesized by treating (1S,3R,8S,9R,10S)-2,2-di­chloro-3,7,7,10-tetra­methyl-9,10-ep­oxy­tri­cyclo­[6.4.0.01,3]dodecane with a concentrated solution of hydro­bromic acid. It is built up from three fused rings: a cyclo­heptane ring, a cyclo­hexyl ring bearing alkene and hy­droxy substituents, and a cyclo­propane ring bearing two chlorine atoms. The asymmetric unit contains two mol­ecules linked by an O—H⋯O hydrogen bond. In the crystal, further O—H⋯O hydrogen bonds build up an R 4 4(8) cyclic tetra­mer. One of the mol­ecules presents disorder that affects the seven-membered ring. In both mol­ecules, the six-membered rings display a chair conformation, whereas the seven-membered rings display conformations inter­mediate between boat and twist-boat for the non-disordered mol­ecule and either a chair or boat and twist-boat for the disordered mol­ecule owing to the disorder. The absolute configuration for both mol­ecules is 1S,3R,8R,9R and was deduced from the chemical pathway and further confirmed by the X-ray structural analysis. PMID:27536404

  13. Synthesis and characterization of quaternary chalcogenides InSn{sub 2}Bi{sub 3}Se{sub 8} and In{sub 0.2}Sn{sub 6}Bi{sub 1.8}Se{sub 9}

    SciTech Connect

    Wang Mingfang; Jang, S.-M.; Huang, J.-C.

    2009-06-15

    Quaternary chalcogenides InSn{sub 2}Bi{sub 3}Se{sub 8} and In{sub 0.2}Sn{sub 6}Bi{sub 1.8}Se{sub 9} were synthesized on direct combination of their elements in stoichiometric ratios at T>800 deg. C under vacuum. Their structures were determined with X-ray diffraction of single crystals. InSn{sub 2}Bi{sub 3}Se{sub 8} crystallizes in monoclinic space group C2/m (No. 12) with a=13.557(3) A, b=4.1299(8) A, c=15.252(3) A, beta=115.73(3){sup o}, V=769.3(3) A{sup 3}, Z=2, and R{sub 1}/wR{sub 2}/GOF=0.0206/0.0497/1.092; In{sub 0.2}Sn{sub 6}Bi{sub 1.8}Se{sub 9} crystallizes in orthorhombic space group Cmc2{sub 1} (No. 36) with a=4.1810(8) A, b=13.799(3) A, c=31.953(6) A, V=1843.4(6) A{sup 3}, Z=4, and R{sub 1}/wR{sub 2}/GOF=0.0966/0.2327/1.12. InSn{sub 2}Bi{sub 3}Se{sub 8} and In{sub 0.2}Sn{sub 6}Bi{sub 1.8}Se{sub 9} are isostructural with CuBi{sub 5}S{sub 8} and Bi{sub 2}Pb{sub 6}S{sub 9} phases, respectively. The structures of InSn{sub 2}Bi{sub 3}Se{sub 8} and In{sub 0.2}Sn{sub 6}Bi{sub 1.8}Se{sub 9} feature a three-dimensional framework containing slabs of NaCl-(311) type with varied thicknesses. Calculations of the electronic structure and measurements of electrical conductivity indicate that these materials are semiconductors with narrow band gaps. Both compounds show n-type semiconducting properties with Seebeck coefficients -270 and -230 muV/K at 300 K for InSn{sub 2}Bi{sub 3}Se{sub 8} and In{sub 0.2}Sn{sub 6}Bi{sub 1.8}Se{sub 9}, respectively. - Graphical abstract: Quaternary selenides InSn{sub 2}Bi{sub 3}Se{sub 8} and In{sub 0.2}Sn{sub 6}Bi{sub 1.8}Se{sub 9} feature three-dimensional frameworks containing NaCl-(311) type slabs with varied thicknesses. Measurements of the electrical conductivity indicate that these materials are n-type semiconductors.

  14. 5-(4-Chloro­phen­yl)-1-methyl-3-phenyl-3,6,8,9-tetra­hydro­pyrazolo­[3,4-b]thio­pyrano[4,3-d]pyridine

    PubMed Central

    Jia, Runhong; Peng, Juhua

    2011-01-01

    The title compound, C22H18ClN3S, was synthesized by the reaction of 4-chloro­benzaldehyde, tetra­hydro­thio­pyran-4-one and 3-methyl-1-phenyl-1H-pyrazol-5-amine in acetic acid without a catalyst. The pyridine and pyrazole rings are almost coplanar, the dihedral angle between their mean planes being 2.50 (1)°. The thio­pyran ring exhibits an envelope conformation. The crystal packing is stabilized by inter­molecular C—H⋯Cl hydrogen bonds and by C—H⋯π and π–π inter­actions [centroid–centroid distances of 3.825 (2) Å between pyridine rings and 3.557 (2) Å between pyrazole and pyridine rings. PMID:22059005

  15. Self-doping processes between planes and chains in the metal-to-superconductor transition of YBa2Cu3O6.9

    PubMed Central

    Magnuson, M.; Schmitt, T.; Strocov, V. N.; Schlappa, J.; Kalabukhov, A. S.; Duda, L.-C.

    2014-01-01

    The interplay between the quasi 1-dimensional CuO-chains and the 2-dimensional CuO2 planes of YBa2Cu3O6+x (YBCO) has been in focus for a long time. Although the CuO-chains are known to be important as charge reservoirs that enable superconductivity for a range of oxygen doping levels in YBCO, the understanding of the dynamics of its temperature-driven metal-superconductor transition (MST) remains a challenge. We present a combined study using x-ray absorption spectroscopy and resonant inelastic x-ray scattering (RIXS) revealing how a reconstruction of the apical O(4)-derived interplanar orbitals during the MST of optimally doped YBCO leads to substantial hole-transfer from the chains into the planes, i.e. self-doping. Our ionic model calculations show that localized divalent charge-transfer configurations are expected to be abundant in the chains of YBCO. While these indeed appear in the RIXS spectra from YBCO in the normal, metallic, state, they are largely suppressed in the superconducting state and, instead, signatures of Cu trivalent charge-transfer configurations in the planes become enhanced. In the quest for understanding the fundamental mechanism for high-Tc-superconductivity (HTSC) in perovskite cuprate materials, the observation of such an interplanar self-doping process in YBCO opens a unique novel channel for studying the dynamics of HTSC. PMID:25388860

  16. Self-doping processes between planes and chains in the metal-to-superconductor transition of YBa2Cu3O6.9.

    PubMed

    Magnuson, M; Schmitt, T; Strocov, V N; Schlappa, J; Kalabukhov, A S; Duda, L-C

    2014-01-01

    The interplay between the quasi 1-dimensional CuO-chains and the 2-dimensional CuO2 planes of YBa(2)Cu(3)O(6+x) (YBCO) has been in focus for a long time. Although the CuO-chains are known to be important as charge reservoirs that enable superconductivity for a range of oxygen doping levels in YBCO, the understanding of the dynamics of its temperature-driven metal-superconductor transition (MST) remains a challenge. We present a combined study using x-ray absorption spectroscopy and resonant inelastic x-ray scattering (RIXS) revealing how a reconstruction of the apical O(4)-derived interplanar orbitals during the MST of optimally doped YBCO leads to substantial hole-transfer from the chains into the planes, i.e. self-doping. Our ionic model calculations show that localized divalent charge-transfer configurations are expected to be abundant in the chains of YBCO. While these indeed appear in the RIXS spectra from YBCO in the normal, metallic, state, they are largely suppressed in the superconducting state and, instead, signatures of Cu trivalent charge-transfer configurations in the planes become enhanced. In the quest for understanding the fundamental mechanism for high-Tc-superconductivity (HTSC) in perovskite cuprate materials, the observation of such an interplanar self-doping process in YBCO opens a unique novel channel for studying the dynamics of HTSC. PMID:25388860

  17. 32 CFR 9.6 - Conduct of the trial.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 1 2011-07-01 2011-07-01 false Conduct of the trial. 9.6 Section 9.6 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS PROCEDURES FOR TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.6 Conduct of the trial. (a) Pretrial...

  18. 40 CFR 721.2465 - Xanthylium, 9-(2-(ethoxycarbonyl)phenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, ethyl sulfate.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.2465 Xanthylium, 9-(2... new uses subject to reporting. (1) The chemical substance identified as xanthylium,...

  19. 40 CFR 721.2465 - Xanthylium, 9-(2-(ethoxycarbonyl)phenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, ethyl sulfate.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.2465 Xanthylium, 9-(2... new uses subject to reporting. (1) The chemical substance identified as xanthylium,...

  20. 40 CFR 721.2465 - Xanthylium, 9-(2-(ethoxycarbonyl)phenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, ethyl sulfate.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.2465 Xanthylium, 9-(2... new uses subject to reporting. (1) The chemical substance identified as xanthylium,...

  1. 40 CFR 721.2465 - Xanthylium, 9-(2-(ethoxycarbonyl)phenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, ethyl sulfate.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.2465 Xanthylium, 9-(2... new uses subject to reporting. (1) The chemical substance identified as xanthylium,...

  2. 40 CFR 721.2465 - Xanthylium, 9-(2-(ethoxycarbonyl)phenyl)-3,6-bis(ethylamino)-2,7-dimethyl-, ethyl sulfate.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT SIGNIFICANT NEW USES OF CHEMICAL SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.2465 Xanthylium, 9-(2... new uses subject to reporting. (1) The chemical substance identified as xanthylium,...

  3. Power scaling of laser diode pumped Pr3+:LiYF4 cw lasers: efficient laser operation at 522.6 nm, 545.9 nm, 607.2 nm, and 639.5 nm.

    PubMed

    Gün, Teoman; Metz, Philip; Huber, Günter

    2011-03-15

    We report efficient cw laser operation of laser diode pumped Pr(3+)-doped LiYF4 crystals in the visible spectral region. Using two InGaN laser diodes emitting at λ(P)=443.9 nm with maximum output power of 1 W each and a 2.9-mm-long crystal with a doping concentration of 0.5%, output powers of 938 mW, 418 mW, 384 mW, and 773 mW were achieved for the laser wavelengths 639.5 nm, 607.2 nm, 545.9 nm, and 522.6 nm, respectively. The maximum absorbed pump powers were approximately 1.5 W, resulting in slope efficiencies of 63.6%, 32.0%, 52.1%, and 61.5%, as well as electro-optical efficiencies of 9.4%, 4.2%, 3.8%, and 7.7%, respectively. Within these experiments, laser diode-pumped laser action at 545.9 nm was demonstrated for what is believed to be the first time. PMID:21403756

  4. PbZr0.4Ti0.6O3 and Ba0.9Sr0.1TiO3 reflectors derived from chemical solutions containing polymers.

    PubMed

    Hu, G J; Shang, J L; Sun, Y; Zhang, T; Wu, J; Xie, J

    2008-09-15

    Ba(0.9)Sr(0.1)TiO3 (BST)-based and PbZr(0.4)Ti(0.6)O(3)-based quasi-periodic multilayers consisting of dense and porous ferroelectric layers have been fabricated by solgel technique using chemical solutions containing polyethylene glycol (PEG) or polyvinylpyrrolidone k30 (PVP). All multilayers exhibit good performance as dielectric mirrors. For each multilayer, the maximum peak reflectivity is over 90% and the photonic stopband width is no less than 30 nm at room temperature. The reflection-band position can be easily tuned by varying the thickness of the bilayer. With the same processing conditions and number of periods, the Bragg reflection performance is almost the same for quasi-periodic PZT multilayers derived from two precursors containing different polymers. The BST multilayers deposited by using a PVP-containing precursor are superior in optical properties, including peak reflectivities and stop-band width, to those deposited by using the PEG-containing solution. PMID:18794931

  5. 29 CFR 9.3 - Coverage.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 1 2012-07-01 2012-07-01 false Coverage. 9.3 Section 9.3 Labor Office of the Secretary of Labor NONDISPLACEMENT OF QUALIFIED WORKERS UNDER SERVICE CONTRACTS (effective date pending) General § 9.3 Coverage. This part applies to all service contracts and their solicitations, except...

  6. 44 CFR 9.3 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Authority. 9.3 Section 9.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for...

  7. 44 CFR 9.3 - Authority.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Authority. 9.3 Section 9.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for...

  8. 44 CFR 9.3 - Authority.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Authority. 9.3 Section 9.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for...

  9. 44 CFR 9.3 - Authority.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Authority. 9.3 Section 9.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for...

  10. 44 CFR 9.3 - Authority.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Authority. 9.3 Section 9.3 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.3 Authority. The authority for...

  11. 17 CFR 9.3 - Provisions referenced.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Provisions referenced. 9.3 Section 9.3 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES RELATING TO REVIEW OF EXCHANGE DISCIPLINARY, ACCESS DENIAL OR OTHER ADVERSE ACTIONS General Provisions § 9.3 Provisions referenced. Except as otherwise provided...

  12. Survey and Interpretation Geophysical of Magnetic Isochrones 4n.2 a 2A.3 (7.9 3.6 Ma) in the Central Part of the Rivera Plate

    NASA Astrophysics Data System (ADS)

    Perez, D. A.; Mortera-Gutierrez, C. A.; Bandy, W. L.; Valle, S.

    2013-05-01

    This study shows the results of six campaigns marine geophysics BABRIP06 in 2006, MAMRIV07 in 2007, MAMRIV08 in 2008, GUAYRIV10 in 2010, BATIBAJA11 in 2011 and MAMRIV12 in 2012, in the abyssal plain in the East Pacific Rise (EPR), on board the UNAM vessel, B/O El Puma. The oceanographic campaigns single beam bathymetric data collected and marine magnetic data. The results allow analyze and study the magnetic texture in the central north of the Rivera plate associated with geological structures and behavior of the seafloor to the isochronous 5A. The systematic survey of the magnetic data provided high resolution on the guidelines of the magnetic anomalies associated with cortical spreading between 7.9 and 3.6 Ma, generated by the northern segment of the East Pacific Rise (EPR), between the Rivera and Tamayo Oceanic Transformants. Multibeam bathymetry data and the acoustic reflectivity of the six campaigns are correlated with the geometry of the magnetic anomalies and seismic reflection profiles to understand the processes that formed the highlight recreational ocean in this area. The main results in this study is the identification of continuous magnetic isochrones 4n.2 to 2A.3, magnetic anomalies associated with seamounts, the geometry of the isochrones associated with a propagator and magnetic anomaly identification of isochronous 3n.3 had not been demonstrated by other oceanographic surveys. Possibly oceanic spreading rate was slower during these epochs and the identification of a cross anomaly was due to a fracture zone that generated the propagator.

  13. Crystal structure of (+)-N-[(1R,5S,6S,9S)-5-hydroxy­methyl-3,3,9-trimethyl-8-oxo-2,4,7-trioxabi­cyclo­[4.3.0]nonan-9-yl]acetamide

    PubMed Central

    Oishi, Takeshi; Tsuzaki, Shun; Sugai, Tomoya; Sato, Takaaki; Chida, Noritaka

    2016-01-01

    In the title compound, C12H19NO6, the six-membered 1,3-dioxane ring adopts a chair-like conformation. The seat of this chair, containing two O atoms, is essentially planar, with a maximum deviation of 0.0021 (12) Å. The five-membered oxolane ring cis-fused to the 1,3-dioxane ring adopts an envelope form. The bridgehead C atom at the flap, which is bonded to the tetra­substituted C atom of the oxolane ring, deviates from the mean plane of other ring atoms by 0.539 (4) Å. In the crystal, classical O—H⋯O and N—H⋯O hydrogen bonds link the mol­ecules into a sheet structure enclosing an R 4 4(24) graph-set motif. Weak inter­molecular C—H⋯O inter­actions support the sheet formation. PMID:27308035

  14. Reactions of the iridathiabenzene complex Cp{sup *}Ir(2,5-dimethylthiophene) with Co{sub 2}(CO){sub 8}, Co{sub 4}(CO){sub 12}, and ({eta}{sup 6}-C{sub 6}H{sub 3}Me{sub 3})Co{sub 4}(CO){sub 9}

    SciTech Connect

    Chen, J.; Young, V.G. Jr.; Angelici, R.J. |

    1996-03-05

    With the goal of preparing an {eta}{sup 6}-iridathiabenzene complex of Co{sub 4}(CO){sub 12}, the ring-opened iridathiabenzene complex Cp{sup *}Ir(C,S-2,5-Me{sub 2}T) (1), where 2,5-Me{sub 2}T is 2,5-dimethylthiophene, was reacted with Co{sub 4}(CO){sub 12}, Co{sub 2}(CO){sub 8}, and ({eta}{sup 6}-C{sub 6}H{sub 3}Me{sub 3})Co{sub 4}(CO){sub 9}. Only in the reaction of ({eta}{sup 6}-C{sub 6}H{sub 3}Me{sub 3})Co{sub 4}(CO){sub 9} under mild conditions (35-40{degree}C) was the {eta}{sup 6}-iridathiabenzene cluster [{eta}{sup 6}-Cp{sup *}Ir(C,S-2,5-Me{sub 2}T)]Co{sub 4}(CO){sub 9} (7) obtained. At higher temperatures, the reaction yielded Cp{sup *}Ir({eta}{sup 4}-2,5-Me{sub 2}T.Co{sub 4}(CO){sub 11}) (6), in which the 2,5-Me{sub 2}T ligand is coordinated through its diene to the Ir and through its sulfur to a Co of the cluster. Reactions of Co{sub 4}(CO){sub 12} and Co{sub 2}(CO){sub 8} with 1 yielded Cp{sup *}Ir({eta}{sup 4}-2,5-Me{sub 2}T.Co{sub 4})(CO){sub 11} (2), an isomer of 6, which converts to the desulfurized linear tetranuclear cluster [Cp{sup *}Ir(C(Me)=CHCH=C(Me))({mu}-CO){sub 2}Co]{sub 2} (3); this species contains bridging iridacyclopentadiene units. Cluster 3 has a structure with a Co{sub 2}({mu}-Co){sub 2} core and Cp{sup *}Ir(C(Me)=CHCH=C(Me))(CO) (4) end groups. In fact, 3 can be prepared form Co{sub 2}(CO){sub 8} and 4. Molecular structures of 2-4 are reported, together with a discussion of pathways that lead to their formation. 30 refs., 3 figs., 7 tabs.

  15. 6 CFR 9.51 - Semi-annual compilation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Semi-annual compilation. 9.51 Section 9.51 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Agency Reports § 9.51 Semi-annual compilation. (a) The head of each agency shall collect and compile...

  16. 6 CFR Appendix A to Part 9 - Certification Regarding Lobbying

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Certification Regarding Lobbying A Appendix A to Part 9 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Pt. 9, App. A Appendix A to Part 9—Certification Regarding Lobbying Certification for...

  17. 6 CFR 9.52 - Inspector General report.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Inspector General report. 9.52 Section 9.52 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Agency Reports § 9.52 Inspector General report. (a) The Inspector General, or other official as specified in paragraph (b) of this section, of...

  18. 6 CFR 9.11 - Agency and legislative liaison.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 6 Domestic Security 1 2014-01-01 2014-01-01 false Agency and legislative liaison. 9.11 Section 9.11 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Activities by Own Employees § 9.11 Agency and legislative liaison. (a) The prohibition on the...

  19. 6 CFR 9.11 - Agency and legislative liaison.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 6 Domestic Security 1 2011-01-01 2011-01-01 false Agency and legislative liaison. 9.11 Section 9.11 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Activities by Own Employees § 9.11 Agency and legislative liaison. (a) The prohibition on the...

  20. 6 CFR 9.11 - Agency and legislative liaison.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 6 Domestic Security 1 2012-01-01 2012-01-01 false Agency and legislative liaison. 9.11 Section 9.11 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Activities by Own Employees § 9.11 Agency and legislative liaison. (a) The prohibition on the...

  1. 6 CFR 9.11 - Agency and legislative liaison.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Agency and legislative liaison. 9.11 Section 9.11 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Activities by Own Employees § 9.11 Agency and legislative liaison. (a) The prohibition on the...

  2. 6 CFR 9.11 - Agency and legislative liaison.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 6 Domestic Security 1 2013-01-01 2013-01-01 false Agency and legislative liaison. 9.11 Section 9.11 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Activities by Own Employees § 9.11 Agency and legislative liaison. (a) The prohibition on the...

  3. 15 CFR 9.6 - Termination of participation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 15 Commerce and Foreign Trade 1 2014-01-01 2014-01-01 false Termination of participation. 9.6 Section 9.6 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY....C. 558. (b) A manufacturer may at any time terminate his participation and responsibilities...

  4. 15 CFR 9.6 - Termination of participation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 15 Commerce and Foreign Trade 1 2011-01-01 2011-01-01 false Termination of participation. 9.6 Section 9.6 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY....C. 558. (b) A manufacturer may at any time terminate his participation and responsibilities...

  5. 15 CFR 9.6 - Termination of participation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 15 Commerce and Foreign Trade 1 2013-01-01 2013-01-01 false Termination of participation. 9.6 Section 9.6 Commerce and Foreign Trade Office of the Secretary of Commerce PROCEDURES FOR A VOLUNTARY....C. 558. (b) A manufacturer may at any time terminate his participation and responsibilities...

  6. 36 CFR 9.3 - Access permits.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... units of the National Park System in Alaska, regulations at 43 CFR part 36 govern access to claims, and... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Access permits. 9.3 Section 9... MANAGEMENT Mining and Mining Claims § 9.3 Access permits. (a) All special use or other permits dealing...

  7. 36 CFR 9.3 - Access permits.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... units of the National Park System in Alaska, regulations at 43 CFR part 36 govern access to claims, and... 36 Parks, Forests, and Public Property 1 2011-07-01 2011-07-01 false Access permits. 9.3 Section 9... MANAGEMENT Mining and Mining Claims § 9.3 Access permits. (a) All special use or other permits dealing...

  8. 9 CFR 3.18 - Terminal facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Animal Welfare regulations (9 CFR parts 1, 2, and 3) must not commingle shipments of dogs or cats with... the Animal Welfare regulations (9 CFR parts 1, 2, and 3), outside any primary enclosure containing a... chapter. (e) Shelter. Any person subject to the Animal Welfare regulations (9 CFR parts 1, 2, and...

  9. 9 CFR 3.18 - Terminal facilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Animal Welfare regulations (9 CFR parts 1, 2, and 3) must not commingle shipments of dogs or cats with... the Animal Welfare regulations (9 CFR parts 1, 2, and 3), outside any primary enclosure containing a... chapter. (e) Shelter. Any person subject to the Animal Welfare regulations (9 CFR parts 1, 2, and...

  10. 9 CFR 3.18 - Terminal facilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Animal Welfare regulations (9 CFR parts 1, 2, and 3) must not commingle shipments of dogs or cats with... the Animal Welfare regulations (9 CFR parts 1, 2, and 3), outside any primary enclosure containing a... chapter. (e) Shelter. Any person subject to the Animal Welfare regulations (9 CFR parts 1, 2, and...

  11. 9 CFR 3.18 - Terminal facilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Animal Welfare regulations (9 CFR parts 1, 2, and 3) must not commingle shipments of dogs or cats with... the Animal Welfare regulations (9 CFR parts 1, 2, and 3), outside any primary enclosure containing a... chapter. (e) Shelter. Any person subject to the Animal Welfare regulations (9 CFR parts 1, 2, and...

  12. 9 CFR 3.18 - Terminal facilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Animal Welfare regulations (9 CFR parts 1, 2, and 3) must not commingle shipments of dogs or cats with... the Animal Welfare regulations (9 CFR parts 1, 2, and 3), outside any primary enclosure containing a... chapter. (e) Shelter. Any person subject to the Animal Welfare regulations (9 CFR parts 1, 2, and...

  13. 48 CFR 9.206-3 - Competition.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 48 Federal Acquisition Regulations System 1 2013-10-01 2013-10-01 false Competition. 9.206-3... CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.206-3 Competition. (a) Presolicitation. If a... solicitation to ascertain whether the number of sources is adequate for competition. (See 9.204(a) for...

  14. 48 CFR 9.206-3 - Competition.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 48 Federal Acquisition Regulations System 1 2014-10-01 2014-10-01 false Competition. 9.206-3... CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.206-3 Competition. (a) Presolicitation. If a... solicitation to ascertain whether the number of sources is adequate for competition. (See 9.204(a) for...

  15. 48 CFR 9.206-3 - Competition.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Competition. 9.206-3... CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.206-3 Competition. (a) Presolicitation. If a... solicitation to ascertain whether the number of sources is adequate for competition. (See 9.204(a) for...

  16. 48 CFR 9.206-3 - Competition.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 48 Federal Acquisition Regulations System 1 2011-10-01 2011-10-01 false Competition. 9.206-3... CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.206-3 Competition. (a) Presolicitation. If a... solicitation to ascertain whether the number of sources is adequate for competition. (See 9.204(a) for...

  17. 48 CFR 9.206-3 - Competition.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 48 Federal Acquisition Regulations System 1 2012-10-01 2012-10-01 false Competition. 9.206-3... CONTRACTOR QUALIFICATIONS Qualifications Requirements 9.206-3 Competition. (a) Presolicitation. If a... solicitation to ascertain whether the number of sources is adequate for competition. (See 9.204(a) for...

  18. Competition between singlet fission and charge separation in solution-processed blend films of 6,13-bis(triisopropylsilylethynyl)pentacene with sterically-encumbered perylene-3,4:9,10-bis(dicarboximide)s.

    PubMed

    Ramanan, Charusheela; Smeigh, Amanda L; Anthony, John E; Marks, Tobin J; Wasielewski, Michael R

    2012-01-11

    The photophysics and morphology of thin films of N,N-bis(2,6-diisopropylphenyl)perylene-3,4:9,10-bis(dicarboximide) (1) and the 1,7-diphenyl (2) and 1,7-bis(3,5-di-tert-butylphenyl) (3) derivatives blended with 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-Pn) were studied for their potential use as photoactive layers in organic photovoltaic (OPV) devices. Increasing the steric bulk of the 1,7-substituents of the perylene-3,4:9,10-bis(dicarboximide) (PDI) impedes aggregation in the solid state. Film characterization data using both atomic force microscopy and X-ray diffraction showed that decreasing the PDI aggregation by increasing the steric bulk in the order 1 < 2 < 3 correlates with a decrease in the density/size of crystalline TIPS-Pn domains. Transient absorption spectroscopy was performed on ~100 nm solution-processed TIPS-Pn:PDI blend films to characterize the charge separation dynamics. These results showed that selective excitation of the TIPS-Pn results in competition between ultrafast singlet fission ((1*)TIPS-Pn + TIPS-Pn → 2 (3*)TIPS-Pn) and charge transfer from (1*)TIPS-Pn to PDIs 1-3. As the blend films become more homogeneous across the series TIPS-Pn:PDI 1 → 2 → 3, charge separation becomes competitive with singlet fission. Ultrafast charge separation forms the geminate radical ion pair state (1)(TIPS-Pn(+•)-PDI(-•)) that undergoes radical pair intersystem crossing to form (3)(TIPS-Pn(+•)-PDI(-•)), which then undergoes charge recombination to yield either (3*)PDI or (3*)TIPS-Pn. Energy transfer from (3*)PDI to TIPS-Pn also yields (3*)TIPS-Pn. These results show that multiple pathways produce the (3*)TIPS-Pn state, so that OPV design strategies based on this system must utilize this triplet state for charge separation. PMID:22111926

  19. (E)-1-(Anthracen-9-yl)-3-(2-chloro-6-fluoro­phen­yl)prop-2-en-1-one: crystal structure and Hirshfeld surface analysis

    PubMed Central

    Abdullah, Amzar Ahlami; Hassan, Nur Hafiq Hanif; Arshad, Suhana; Khalib, Nuridayanti Che; Razak, Ibrahim Abdul

    2016-01-01

    In the title compound, C23H14ClFO, the enone moiety adopts an E conformation. The dihedral angle between the benzene and anthracene ring is 63.42 (8)° and an intra­molecular C—H⋯F hydrogen bond generates an S(6) ring motif. In the crystal, mol­ecules are arranged into centrosymmetric dimers via pairs of C—H⋯F hydrogen bonds. The crystal structure also features C—H⋯π and π–π inter­actions. Hirshfeld surface analysis was used to confirm the existence of inter­molecular inter­actions. PMID:27308010

  20. 9 CFR 3.85 - Employees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Primates 2 Animal Health and Husbandry Standards § 3.85 Employees. Every person subject to the Animal Welfare regulations (9 CFR parts 1, 2, and 3) maintaining nonhuman primates must have enough employees to... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Employees. 3.85 Section 3.85...

  1. In vitro effects of vitamins C and E, n-3 and n-6 PUFA and n-9 MUFA on placental cell function and redox status in type 1 diabetic pregnant women.

    PubMed

    Mezouar, Djamila; Merzouk, Hafida; Merzouk, Amel Saidi; Merzouk, Sid Ahmed; Belarbi, Boumediene; Narce, Michel

    2016-06-01

    The aim of this investigation was to determine the in vitro effects of vitamin C and E, n-3 and n-6 PUFA and n-9 MUFA on placental cell proliferation and function in type 1 diabetes. Placenta tissues were collected from 30 control healthy and 30 type 1 diabetic women at delivery. Placental cells were isolated and were cultured in RPMI medium supplemented with vitamin C (50 μM), vitamin E (50 μM), n-3 PUFA (100 μM), n-6 PUFA (100 μM) or n-9 MUFA (100 μM). Cell proliferation, cell glucose uptake and intracellular oxidative status were investigated. Our results showed that basal placental cell proliferation, glucose uptake, malondialdehyde (MDA) and carbonyl proteins were higher while intracellular reduced glutathione (GSH) levels and catalase activities were lower in placentas from diabetic women as compared to controls. Vitamins C and E induced a modulation of placental cell proliferation and glucose consumption without affecting intracellular redox status in both diabetic and control groups. N-3 and n-6 PUFA diminished placental cell proliferation and enhanced intracellular oxidative stress while n-9 MUFA had no effects in the two groups. Co-administration of n-3 or n-6 PUFA and vitamin C or E were capable of reversing back the PUFA-decreased cell proliferation and normalizing placental cell function and redox status especially in diabetes. In conclusion, PUFA and antioxidant vitamin combinations may be beneficial in improving placenta function and in reducing placental oxidative stress in type 1 diabetic pregnancy. PMID:27238721

  2. Discipline-Based Art Education and Cultural Diversity. Seminar Proceedings of a National Invitational Seminar (3rd, Austin Texas, August 6-9, 1992).

    ERIC Educational Resources Information Center

    Getty Center for Education in the Arts, Los Angeles, CA.

    This publication contains proceedings of a seminar structured around five basic themes: (1) cultural diversity in education; (2) discipline based art education (DBAE) and cultural diversity; (3) how cultural diversity has affected practices in art history, aesthetics, criticism, and art making; (4) experiences in other disciplines which effect…

  3. 9 CFR 78.6 - Steers and spayed heifers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Steers and spayed heifers. 78.6 Section 78.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... Restrictions on Interstate Movement of Cattle Because of Brucellosis § 78.6 Steers and spayed heifers....

  4. 9 CFR 78.6 - Steers and spayed heifers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Steers and spayed heifers. 78.6 Section 78.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... Restrictions on Interstate Movement of Cattle Because of Brucellosis § 78.6 Steers and spayed heifers....

  5. 9 CFR 114.6 - Mixing biological products.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Mixing biological products. 114.6 Section 114.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... BIOLOGICAL PRODUCTS § 114.6 Mixing biological products. Each biological product, when in liquid form,...

  6. 9 CFR 114.6 - Mixing biological products.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Mixing biological products. 114.6 Section 114.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... BIOLOGICAL PRODUCTS § 114.6 Mixing biological products. Each biological product, when in liquid form,...

  7. 9 CFR 114.6 - Mixing biological products.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Mixing biological products. 114.6 Section 114.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... BIOLOGICAL PRODUCTS § 114.6 Mixing biological products. Each biological product, when in liquid form,...

  8. 9 CFR 114.6 - Mixing biological products.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Mixing biological products. 114.6 Section 114.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... BIOLOGICAL PRODUCTS § 114.6 Mixing biological products. Each biological product, when in liquid form,...

  9. 9 CFR 114.6 - Mixing biological products.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Mixing biological products. 114.6 Section 114.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... BIOLOGICAL PRODUCTS § 114.6 Mixing biological products. Each biological product, when in liquid form,...

  10. 9 CFR 55.6 - Mortgage against animals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Mortgage against animals. 55.6 Section 55.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... DISEASE Chronic Wasting Disease Indemnification Program § 55.6 Mortgage against animals. When cervids...

  11. 9 CFR 55.6 - Mortgage against animals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Mortgage against animals. 55.6 Section 55.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... DISEASE Chronic Wasting Disease Indemnification Program § 55.6 Mortgage against animals. When cervids...

  12. 9 CFR 55.6 - Mortgage against animals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Mortgage against animals. 55.6 Section 55.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... DISEASE Chronic Wasting Disease Indemnification Program § 55.6 Mortgage against animals. When cervids...

  13. 9 CFR 55.6 - Mortgage against animals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Mortgage against animals. 55.6 Section 55.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... DISEASE Chronic Wasting Disease Indemnification Program § 55.6 Mortgage against animals. When cervids...

  14. 9 CFR 55.6 - Mortgage against animals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Mortgage against animals. 55.6 Section 55.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... DISEASE Chronic Wasting Disease Indemnification Program § 55.6 Mortgage against animals. When cervids...

  15. 9 CFR 112.6 - Packaging biological products.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Packaging biological products. 112.6 Section 112.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PACKAGING AND LABELING § 112.6 Packaging biological products....

  16. GEO-CAPE application, demonstrated for CO by the IIP Tropospheric Infrared Mapping Spectrometers (TIMS), and scaled to an expanded application that adds the 9.6, 3.3 and 3.6 um bands for multi-layer tropospheric ozone and for HCHO

    NASA Astrophysics Data System (ADS)

    Kumer, J. B.; Roche, A. E.; Rairden, R. L.; Jamieson, T. H.; Mergenthaler, J. L.; Chatfield, R. B.

    2008-12-01

    The NASA Earth Science Technology Office (ESTO) Instrument Incubator Program (IIP) Tropospheric Infrared Mapping Spectrometers (TIMS) have been developed to demonstrate measurement capability, when deployed in space, for multi-layer retrieval of CO from spectral measurements acquired in the solar reflective (SR) region ~ 4281 to 4301 cm-1 and in the thermal InfraRed (TIR) region ~ 2110 to 2165 cm 1. As presented at this meeting in our poster "...multi-layer CO retrieval from atmospheric data..." very encouraging retrieval for CO, H2O, CH4 and albedo were obtained in an operational mode of ground based atmospheric observations that simulated space based operations in an application that would meet Decadal Survey GEO- CAPE air quality observation requirements for coverage, footprint size and refresh time. In this presentation we'll describe the details of how the ground based operations map to the space based operations. We will discuss concept details including [a] the approach for instrument cooling, [b] the scanning mirror and telescope system that would provide input to the TIMS in a way that meets the GEO-CAPE measurement requirements, [c] telemetry requirements, and [d] the scaling of retrieval precision from the ground based actuals to the space based operations. For example, the ground based actual TIMS column precisions for retrieval from the SR data scale to space deployed TIMS column retrieval precisions for CO(=8.6%), H2O(=3.7%), CH4(=0.9%) and for albedo(=0.2%) on the GEO-CAPE minimum footprint. We'll also present the actuals, and the scaling to the GEO-CAPE case, for multi-layer CO and H2O retrieval from the combined SR and TIR data sets. The required aperture is quite small, 7.5 cm. We will also present a straight forward approach to expand the GEO-CAPE TIMS concept to additional spectral regions near 3.3, 3.6 and 9.6 um that will provide for multi-layer retrieval of tropospheric ozone, and for HCHO column. The approach adds relatively small mass, but

  17. 5,8-Bis[bis-(pyridin-2-yl)amino]-1,3,4,6,7,9,9b-hepta-aza-phenalen-2(1H)-one dimethyl sulfoxide monosolvate dihydrate.

    PubMed

    Schwarzer, Anke; Kroke, Edwin

    2014-04-01

    In the asymmetric unit of the title compound, C26H17N13O·C2H6OS·2H2O, there is one independent hepta-zine-based main mol-ecule, one dimethyl sulfoxide mol-ecule and two water mol-ecules as solvents. The tri-s-triazine unit is substituted with two dipyridyl amine moieties and a carbonylic O atom. As indicated by the bond lengths in this acid unit of the hepta-zine derivative [C=O = 1.213 (2) Å, while the adjacent C-N(H) bond = 1.405 (2) Å] it is best described by the keto form. The cyameluric nucleus is close to planar (r.m.s. deviation = 0.061 Å) and the pyridine rings are inclined to its mean plane by dihedral angles varying from 47.47 (5) to 70.22 (5)°. The host and guest mol-ecules are connected via N-H⋯O, O-H⋯O and O-H⋯N hydrogen bonds, forming a four-membered inversion dimer-like arrangement enclosing an R 4 (4)(24) ring motif. These arrangements stack along [1-10] with a weak π-π inter-action [inter-centroid distance = 3.8721 (12) Å] involving adjacent pyridine rings. There are also C-H⋯N and C-H⋯O hydrogen bonds and C-H⋯π inter-actions present within the host mol-ecule and linking inversion-related mol-ecules, forming a three-dimensional structure. PMID:24826156

  18. Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism.

    PubMed

    Annese, V; Herrero, María-Trinidad; Di Pentima, M; Gomez, A; Lombardi, L; Ros, C M; De Pablos, V; Fernandez-Villalba, E; De Stefano, Maria Egle

    2015-03-01

    Inflammation is a predominant aspect of neurodegenerative diseases, manifested by glia activation and expression of pro-inflammatory mediators. Studies on animal models of Parkinson's disease (PD) suggest that sustained neuroinflammation exacerbates degeneration of the dopaminergic (DA) nigro-striatal pathway. Therefore, insights into the inflammatory mechanisms of PD may help the development of novel therapeutic strategies against this disease. As extracellular matrix metalloproteinases (MMPs) could be major players in the progression of Parkinsonism, we investigated, in the substantia nigra and striatum of mice acutely injected with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), changes in mRNA expression, protein levels, and cell localization of MMP-9. This protease is mainly neuronal, but early after MPTP injection its mRNA and protein levels, as well as the number of MMP-9-expressing microglia and astrocytes, increase concomitantly to a prominent inflammation. Neuroinflammation and MMP-9(+) glia begin to decline within 2 weeks, although protein levels remain higher than control, in association with a partial recovery of DA nigro-striatal circuit. Comparable quantitative studies on MMP-9 knock-out mice, show a significant decrease in both glia activation and loss of DA neurons and fibers, with respect to wild-type. Moreover, in a parallel study on chronically MPTP-injected macaques, we observed that perpetuation of inflammation and high levels of MMP-9 are associated to DA neuron loss. Our data suggest that MMP-9 released by injured neurons favors glia activation; glial cells in turn reinforce their reactive state via autocrine MMP-9 release, contributing to nigro-striatal pathway degeneration. Specific modulation of MMP-9 activity may, therefore, be a strategy to ameliorate harmful inflammatory outcomes in Parkinsonism. PMID:24558048

  19. Photochemistry of 1 and 2-(2-methylphenyl)-1,6-heptadiene. [4a-methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene

    SciTech Connect

    Barrows, R.D.; Hornback, J.M.

    1982-01-01

    In an attempt to synthesize partially saturated phenanthrene derivatives by an intramolecular Diels-Alder reaction between a photochemically produced o-xylylene (diene) and a tethered dienophile, it was found that 1 and 2 underwent a photochemically allowed (2 + 2) cycloaddition. Irradiation of 1 gave 6-(2-methylphenyl)bicyclo(3.2.0)heptane in 86% yield. Upon irradiation of 2, a benzvalene rearrangement of 2 first took place, producing the meta isomer 2-(3-methylphenyl)-1,6-heptadiene, followed by a (2 + 2) photocycloaddition giving 1-(3-methylphenyl)bicyclo(3.2.0)heptane in 15% yield. Direct irradiation of 2-(3-methylphenyl)-1,6-heptadiene gave the same bicyclo derivative as 2 in 34% yield. Examination of the fluorescence spectra of 1 and 2 in comparison with 1-(2-methylphenyl)propene and 2-(2-methylphenyl)-1-butene, respectively, has shown that 1 may be biased toward (2 + 2) cycloaddition where 2 is not biased toward (2 + 2) photocycloization. Attempts to produce 4a-methyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene by an intramolecular Diels-Alder reaction of the o-xylylene produced by irradiation of 3 will also be described.

  20. The 3-D surface deformation, coseismic fault slip and after-slip of the 2010 Mw6.9 Yushu earthquake, Tibet, China

    NASA Astrophysics Data System (ADS)

    Zhang, Guohong; Shan, Xinjian; Feng, Guangcai

    2016-07-01

    Using SAR interferometry on C band Envisat descending track and L band ALOS ascending track SAR images, respectively, we firstly obtain two coseismic deformation fields and one postseismic deformation of the 2010 Yushu earthquake, Tibet, China. In the meanwhile, we also obtain the azimuthal coseismic deformation of the Yushu event by Multi Aperture Interferometry (MAI) technique. With the 3 components of one-dimensional coseismic InSAR measurements, we resolve the complete 3-dimensional deformation of the 2010 Yushu event, which shows conformity and complexity to left lateral slip mechanism. The horizontal deformation is basically consistent with a sinistral slip event; whereas the vertical displacement does show certain level of complexity, which we argue is indicative of local fault geometry variation. Based on the InSAR data and elastic dislocation assumption, we invert for coseismic fault slip and early after-slip of the Yushu event. Our inversion results show major coseismic left lateral strike slip with only minor thrust component. The after-slip model fills most of the slip gaps left by the coseismic fault slip and finds a complementary slip distribution to the coseismic fault slip, which is a good indicator that future earthquake potential on the Yushu segment has been significantly reduced.

  1. 9 CFR 3.85 - Employees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Welfare regulations (9 CFR parts 1, 2, and 3) maintaining nonhuman primates must have enough employees to... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Employees. 3.85 Section 3.85 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...

  2. 9 CFR 3.91 - Terminal facilities.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Animal Welfare regulations (9 CFR parts l, 2, and 3) must not commingle shipments of nonhuman primates... CFR parts 1, 2, and 3), outside any primary enclosure containing a nonhuman primate at a point not... subject to the Animal Welfare regulations (9 CFR parts l, 2, and 3) holding a nonhuman primate in...

  3. 9 CFR 3.91 - Terminal facilities.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Animal Welfare regulations (9 CFR parts l, 2, and 3) must not commingle shipments of nonhuman primates... CFR parts 1, 2, and 3), outside any primary enclosure containing a nonhuman primate at a point not... subject to the Animal Welfare regulations (9 CFR parts l, 2, and 3) holding a nonhuman primate in...

  4. 9 CFR 3.91 - Terminal facilities.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Animal Welfare regulations (9 CFR parts l, 2, and 3) must not commingle shipments of nonhuman primates... CFR parts 1, 2, and 3), outside any primary enclosure containing a nonhuman primate at a point not... subject to the Animal Welfare regulations (9 CFR parts l, 2, and 3) holding a nonhuman primate in...

  5. 9 CFR 3.91 - Terminal facilities.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Animal Welfare regulations (9 CFR parts l, 2, and 3) must not commingle shipments of nonhuman primates... CFR parts 1, 2, and 3), outside any primary enclosure containing a nonhuman primate at a point not... subject to the Animal Welfare regulations (9 CFR parts l, 2, and 3) holding a nonhuman primate in...

  6. 9 CFR 3.91 - Terminal facilities.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Animal Welfare regulations (9 CFR parts l, 2, and 3) must not commingle shipments of nonhuman primates... CFR parts 1, 2, and 3), outside any primary enclosure containing a nonhuman primate at a point not... subject to the Animal Welfare regulations (9 CFR parts l, 2, and 3) holding a nonhuman primate in...

  7. 28 CFR 9.6 - Special rules for specific petitioners.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... MITIGATION OF CIVIL AND CRIMINAL FORFEITURES § 9.6 Special rules for specific petitioners. (a) General... long-term basis with the right to sublease shall not be entitled to remission or mitigation of...

  8. 6. DETAIL VIEW OF 210' 9' LIFT SPAN TOWER SHEAVES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. DETAIL VIEW OF 210' 9' LIFT SPAN TOWER SHEAVES AND BEARINGS WITH HOUSING AND SHEAVE HOODS REMOVED - Central Railroad of New Jersey, Newark Bay Lift Bridge, Spanning Newark Bay, Newark, Essex County, NJ

  9. 6. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic American Buildings Survey Alexander Piaget, Photographer, April 9, 1934 DETAIL OF ROTUNDA - LOOKING NORTH - Old St. Louis Courthouse, Fourth to Broadway, Market to Chestnut Streets, Saint Louis, Independent City, MO

  10. Crystal structure of 10a-hy­droxy-9-(3-nitro­phen­yl)-3,6-diphenyl-3,4,5,6,7,8a,9,10a-octa­hydro-1H-xanthene-1,8(2H)-dione

    PubMed Central

    Zhang, Xin-Yuan; Hu, Bing-Xiang; Zhou, Ze-Yu; Zhou, Lei; Wang, Fang-Ming

    2015-01-01

    In the octa­hydroxanthenedione unit of the title compound, C31H27NO6, the central di­hydro­pyran ring shows an envelope conformation, while the bilateral cyclo­hexene and cyclo­hexane rings adopt a half-boat conformation and a chair conformation, respectively. The nitro­benzene ring is twisted with respect to the two benzene rings, making dihedral angles of 63.1 (1) and 63.0 (1)°. In the crystal, O—H⋯O hydrogen bonds link the mol­ecules into supra­molecular chains propagating along the a-axis direction. PMID:26870416

  11. 9 CFR 78.6 - Steers and spayed heifers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Restrictions on Interstate Movement of Cattle Because of Brucellosis § 78.6 Steers and spayed heifers. Steers and spayed heifers may be moved interstate in accordance with 9 CFR part 86 and without further... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Steers and spayed heifers....

  12. 6. Historic view, Pier 9, 10, 11. Aerial Views to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Historic view, Pier 9, 10, 11. Aerial Views to east, 1943. Photographic copy of photo. Boston National Historical Park Archives, Charlestown Navy Yard. - Charlestown Navy Yard, Pier 9, Between Piers 8 & 10, along Mystic River on Charlestown Waterfront at eastern edge of Navy Yard, Boston, Suffolk County, MA

  13. 6 CFR 9.41 - Secretary of Defense.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Congress immediately after making such a determination. (b) The Department of Defense may issue... 6 Domestic Security 1 2014-01-01 2014-01-01 false Secretary of Defense. 9.41 Section 9.41 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Exemptions §...

  14. 6 CFR 9.41 - Secretary of Defense.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Congress immediately after making such a determination. (b) The Department of Defense may issue... 6 Domestic Security 1 2012-01-01 2012-01-01 false Secretary of Defense. 9.41 Section 9.41 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Exemptions §...

  15. 6 CFR 9.41 - Secretary of Defense.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Congress immediately after making such a determination. (b) The Department of Defense may issue... 6 Domestic Security 1 2011-01-01 2011-01-01 false Secretary of Defense. 9.41 Section 9.41 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Exemptions §...

  16. 6 CFR 9.41 - Secretary of Defense.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Congress immediately after making such a determination. (b) The Department of Defense may issue... 6 Domestic Security 1 2010-01-01 2010-01-01 false Secretary of Defense. 9.41 Section 9.41 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Exemptions §...

  17. 6 CFR 9.41 - Secretary of Defense.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Congress immediately after making such a determination. (b) The Department of Defense may issue... 6 Domestic Security 1 2013-01-01 2013-01-01 false Secretary of Defense. 9.41 Section 9.41 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY RESTRICTIONS UPON LOBBYING Exemptions §...

  18. Genome-wide association study identifies susceptibility loci in IL6, RPS9/LILRB3, and an intergenic locus on chromosome 21q22 in Takayasu’s arteritis

    PubMed Central

    Renauer, Paul; Saruhan-Direskeneli, Guher; Coit, Patrick; Adler, Adam; Aksu, Kenan; Keser, Gokhan; Alibaz-Oner, Fatma; Aydin, Sibel Z.; Kamali, Sevil; Inanc, Murat; Carette, Simon; Cuthbertson, David; Hoffman, Gary S.; Akar, Servet; Onen, Fatos; Akkoc, Nurullah; Khalidi, Nader A.; Koening, Curry; Karadag, Omer; Kiraz, Sedat; Langford, Carol A.; Maksimowicz-McKinnon, Kathleen; McAlear, Carol A.; Ozbalkan, Zeynep; Ates, Askin; Karaaslan, Yasar; Duzgun, Nursen; Monach, Paul A.; Ozer, Huseyin TE; Erken, Eren; Ozturk, Mehmet A.; Yazici, Ayten; Cefle, Ayse; Onat, A. Mesut; Kisacik, Bunyamin; Pagnoux, Christian; Kasifoglu, Timucin; Seyahi, Emire; Fresko, Izzet; Seo, Philip; Sreih, Antoine; Warrington, Kenneth J.; Ytterberg, Steven R.; Cobankara, Veli; Cunninghame-Graham, Deborah S.; Vyse, Timothy J.; Pamuk, Omer N.; Tunc, Ercan; Dalkilic, Ediz; Bicakcigil, Muge; Yentur, Sibel P.; Wren, Jonathan D.; Merkel, Peter A.; Direskeneli, Haner; Sawalha, Amr H.

    2015-01-01

    Objective Takayasu’s arteritis is a rare large vessel vasculitis with incompletely understood etiology. We performed the first unbiased genome-wide association study (GWAS) in Takayasu’s arteritis. Methods Two independent Takayasu’s arteritis cohorts from Turkey and North America were included in our study. The Turkish cohort consisted of 559 patients and 489 controls, and the North American cohort consisted of 134 European-derived patients and 1,047 controls. Genotyping was performed using the Omni1-Quad and Omni2.5 genotyping arrays. Genotyping data were subjected to rigorous quality control measures and subsequently analyzed to discover genetic susceptibility loci for Takayasu’s arteritis. Results We identified genetic susceptibility loci for Takayasu’s arteritis with a genome-wide level of significance in IL6 (rs2069837, OR= 2.07, P= 6.70×10−9), RPS9/LILRB3 (rs11666543, OR= 1.65, P= 2.34×10−8), and an intergenic locus on chromosome 21q22 (rs2836878, OR= 1.79, P= 3.62×10−10). The genetic susceptibility locus in RPS9/LILRB3 is located within the leukocyte receptor complex (LRC) gene cluster on chromosome 19q13.4, and the disease risk variant in this locus correlates with reduced expression of multiple genes including the inhibitory leukocyte immunoglobulin-like receptor gene LILRB3 (P= 2.29×10−8). In addition, we identified candidate susceptibility genes with suggestive levels of association (P <1×10−5) including PCSK5, LILRA3, PPM1G/NRBP1, and PTK2B in Takayasu’s arteritis. Conclusion This study identified novel genetic susceptibility loci for Takayasu’s arteritis and uncovered potentially important aspects in the pathophysiology of this form of vasculitis. PMID:25604533

  19. 40 CFR 721.10271 - 3′H-Cyclopropa[1,9][5,6]fullerene-C60-Ih-3′-butanoic acid, 3′-phenyl-, methyl ester.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 32 2013-07-01 2013-07-01 false 3â²H-Cyclopropa fullerene-C60-Ih-3â²... SUBSTANCES Significant New Uses for Specific Chemical Substances § 721.10271 3′H-Cyclopropa fullerene-C60-Ih... to reporting. (1) The chemical substance identified as 3′H-Cyclopropa...

  20. Comparative effects of n-3, n-6 and n-9 unsaturated fatty acid-rich diet consumption on lupus nephritis, autoantibody production and CD4+ T cell-related gene responses in the autoimmune NZBWF1 mouse.

    PubMed

    Pestka, James J; Vines, Laura L; Bates, Melissa A; He, Kaiyu; Langohr, Ingeborg

    2014-01-01

    Mortality from systemic lupus erythematosus (SLE), a prototypical autoimmune disease, correlates with the onset and severity of kidney glomerulonephritis. There are both preclinical and clinical evidence that SLE patients may benefit from consumption of n-3 polyunsaturated fatty acids (PUFA) found in fish oil, but the mechanisms remain unclear. Here we employed the NZBWF1 SLE mouse model to compare the effects of dietary lipids on the onset and severity of autoimmune glomerulonephritis after consuming: 1) n-3 PUFA-rich diet containing docosahexaenoic acid-enriched fish oil (DFO), 2) n-6 PUFA-rich Western-type diet containing corn oil (CRN) or 3) n-9 monounsaturated fatty acid (MUFA)-rich Mediterranean-type diet containing high oleic safflower oil (HOS). Elevated plasma autoantibodies, proteinuria and glomerulonephritis were evident in mice fed either the n-6 PUFA or n-9 MUFA diets, however, all three endpoints were markedly attenuated in mice that consumed the n-3 PUFA diet until 34 wk of age. A focused PCR array was used to relate these findings to the expression of 84 genes associated with CD4+ T cell function in the spleen and kidney both prior to and after the onset of the autoimmune nephritis. n-3 PUFA suppression of autoimmunity in NZBWF1 mice was found to co-occur with a generalized downregulation of CD4+ T cell-related genes in kidney and/or spleen at wk 34. These genes were associated with the inflammatory response, antigen presentation, T cell activation, B cell activation/differentiation and leukocyte recruitment. Quantitative RT-PCR of representative affected genes confirmed that n-3 PUFA consumption was associated with reduced expression of CD80, CTLA-4, IL-10, IL-18, CCL-5, CXCR3, IL-6, TNF-α and osteopontin mRNAs in kidney and/or spleens as compared to mice fed n-6 PUFA or n-9 MUFA diets. Remarkably, many of the genes identified in this study are currently under consideration as biomarkers and/or biotherapeutic targets for SLE and other autoimmune

  1. Photoimaging of the multiple filamentation of femtosecond laser pulses in poly(methyl methacrylate) doped with 2,2-difluoro-4-(9-anthracyl)-6-methyl-1,3,2-dioxaborine

    SciTech Connect

    Kulchin, Yu N; Vitrik, O B; Chekhlenok, A A; Zhizhchenko, A Yu; Proschenko, D Yu; Mirochnik, A G; Lyu Guohui

    2013-12-31

    We have studied the filamentation of femtosecond laser pulses (λ = 800 nm, ∼42 fs pulse duration) in poly(methyl methacrylate) doped with 2,2-difluoro-4-(9-anthracyl)-6-methyl-1,3,2- dioxaborine and the associated photomodification of the material. The results demonstrate that multiple filamentation occurs at pulse energies above 5 μJ. At a pulse energy of 1.5 mJ, it is accompanied by supercontinuum generation. The average filament length in PMMA is 9 mm and the filament diameter is ∼10 μm. An incident power density of ∼10{sup 12} W cm{sup -2} ensures inscription of the filament pattern owing to two-photon photochemical processes. Preliminary exposure to continuous light at λ = 400 nm enables an ordered filament pattern to be written. (interaction of laser radiation with matter)

  2. 18 CFR 9.3 - Transfer.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false Transfer. 9.3 Section 9.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT TRANSFER OF LICENSE OR LEASE OF PROJECT...

  3. 18 CFR 9.3 - Transfer.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false Transfer. 9.3 Section 9.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT TRANSFER OF LICENSE OR LEASE OF PROJECT...

  4. 18 CFR 9.3 - Transfer.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Transfer. 9.3 Section 9.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT TRANSFER OF LICENSE OR LEASE OF PROJECT...

  5. 18 CFR 9.3 - Transfer.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false Transfer. 9.3 Section 9.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT TRANSFER OF LICENSE OR LEASE OF PROJECT...

  6. 18 CFR 9.3 - Transfer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Transfer. 9.3 Section 9.3 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION, DEPARTMENT OF ENERGY REGULATIONS UNDER THE FEDERAL POWER ACT TRANSFER OF LICENSE OR LEASE OF PROJECT...

  7. 9 CFR 309.6 - Epithelioma of the eye.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Epithelioma of the eye. 309.6 Section... CERTIFICATION ANTE-MORTEM INSPECTION § 309.6 Epithelioma of the eye. Any animal found on ante-mortem inspection to be affected with epithelioma of the eye and the orbital region in which the eye has been...

  8. 9 CFR 309.6 - Epithelioma of the eye.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Epithelioma of the eye. 309.6 Section... CERTIFICATION ANTE-MORTEM INSPECTION § 309.6 Epithelioma of the eye. Any animal found on ante-mortem inspection to be affected with epithelioma of the eye and the orbital region in which the eye has been...

  9. 9 CFR 309.6 - Epithelioma of the eye.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Epithelioma of the eye. 309.6 Section... CERTIFICATION ANTE-MORTEM INSPECTION § 309.6 Epithelioma of the eye. Any animal found on ante-mortem inspection to be affected with epithelioma of the eye and the orbital region in which the eye has been...

  10. 9 CFR 309.6 - Epithelioma of the eye.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Epithelioma of the eye. 309.6 Section... CERTIFICATION ANTE-MORTEM INSPECTION § 309.6 Epithelioma of the eye. Any animal found on ante-mortem inspection to be affected with epithelioma of the eye and the orbital region in which the eye has been...

  11. 9 CFR 309.6 - Epithelioma of the eye.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Epithelioma of the eye. 309.6 Section... CERTIFICATION ANTE-MORTEM INSPECTION § 309.6 Epithelioma of the eye. Any animal found on ante-mortem inspection to be affected with epithelioma of the eye and the orbital region in which the eye has been...

  12. 9 CFR 355.6 - Review of applications.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Review of applications. 355.6 Section 355.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION CERTIFIED PRODUCTS FOR...

  13. 9 CFR 417.6 - Inadequate HACCP Systems.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Inadequate HACCP Systems. 417.6 Section 417.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE REGULATORY REQUIREMENTS UNDER THE FEDERAL MEAT INSPECTION ACT AND THE POULTRY PRODUCTS INSPECTION ACT...

  14. 9 CFR 417.6 - Inadequate HACCP Systems.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Inadequate HACCP Systems. 417.6 Section 417.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE REGULATORY REQUIREMENTS UNDER THE FEDERAL MEAT INSPECTION ACT AND THE POULTRY PRODUCTS INSPECTION ACT...

  15. 9 CFR 104.6 - Products for transit shipment only.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Products for transit shipment only. 104.6 Section 104.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS...

  16. 9 CFR 112.6 - Packaging biological products.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Packaging biological products. 112.6... § 112.6 Packaging biological products. (a) Each multiple-dose final container of a biological product... equipment. (e) Final containers of biological product prepared at a licensed establishment, or imported,...

  17. 9 CFR 112.6 - Packaging biological products.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Packaging biological products. 112.6... § 112.6 Packaging biological products. (a) Each multiple-dose final container of a biological product... equipment. (e) Final containers of biological product prepared at a licensed establishment, or imported,...

  18. 9 CFR 112.6 - Packaging biological products.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Packaging biological products. 112.6... § 112.6 Packaging biological products. (a) Each multiple-dose final container of a biological product... equipment. (e) Final containers of biological product prepared at a licensed establishment, or imported,...

  19. 9 CFR 112.6 - Packaging biological products.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Packaging biological products. 112.6... § 112.6 Packaging biological products. (a) Each multiple-dose final container of a biological product... equipment. (e) Final containers of biological product prepared at a licensed establishment, or imported,...

  20. 9 CFR 311.6 - Diamond-skin disease.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Diamond-skin disease. 311.6 Section... CERTIFICATION DISPOSAL OF DISEASED OR OTHERWISE ADULTERATED CARCASSES AND PARTS § 311.6 Diamond-skin disease. Carcasses of hogs affected with diamond-skin disease when localized and not associated with systemic...

  1. 9 CFR 311.6 - Diamond-skin disease.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Diamond-skin disease. 311.6 Section... CERTIFICATION DISPOSAL OF DISEASED OR OTHERWISE ADULTERATED CARCASSES AND PARTS § 311.6 Diamond-skin disease. Carcasses of hogs affected with diamond-skin disease when localized and not associated with systemic...

  2. 9 CFR 311.6 - Diamond-skin disease.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Diamond-skin disease. 311.6 Section... CERTIFICATION DISPOSAL OF DISEASED OR OTHERWISE ADULTERATED CARCASSES AND PARTS § 311.6 Diamond-skin disease. Carcasses of hogs affected with diamond-skin disease when localized and not associated with systemic...

  3. 9 CFR 311.6 - Diamond-skin disease.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Diamond-skin disease. 311.6 Section... CERTIFICATION DISPOSAL OF DISEASED OR OTHERWISE ADULTERATED CARCASSES AND PARTS § 311.6 Diamond-skin disease. Carcasses of hogs affected with diamond-skin disease when localized and not associated with systemic...

  4. 9 CFR 311.6 - Diamond-skin disease.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Diamond-skin disease. 311.6 Section... CERTIFICATION DISPOSAL OF DISEASED OR OTHERWISE ADULTERATED CARCASSES AND PARTS § 311.6 Diamond-skin disease. Carcasses of hogs affected with diamond-skin disease when localized and not associated with systemic...

  5. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Annual license fees. 2.6 Section 2.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... submitted to the appropriate Animal Care regional office, and, in the case of license renewals, all...

  6. 9 CFR 145.6 - Specific provisions for participating hatcheries.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Specific provisions for participating hatcheries. 145.6 Section 145.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... in § 145.10. (f) If a person is responsibly connected with more than one hatchery, all of...

  7. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Annual license fees. 2.6 Section 2.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... submitted to the appropriate Animal Care regional office, and, in the case of license renewals, all...

  8. 9 CFR 145.6 - Specific provisions for participating hatcheries.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Specific provisions for participating hatcheries. 145.6 Section 145.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... in § 145.10. (f) If a person is responsibly connected with more than one hatchery, all of...

  9. 9 CFR 56.6 - Presentation of claims for indemnity.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Presentation of claims for indemnity. 56.6 Section 56.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES CONTROL OF...

  10. 9 CFR 54.6 - Amount of indemnity payments.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Amount of indemnity payments. 54.6 Section 54.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES CONTROL OF SCRAPIE...

  11. 9 CFR 52.6 - Claims not allowed.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Claims not allowed. 52.6 Section 52.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES SWINE DESTROYED BECAUSE OF...

  12. 9 CFR 56.6 - Presentation of claims for indemnity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Presentation of claims for indemnity. 56.6 Section 56.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE COOPERATIVE CONTROL AND ERADICATION OF LIVESTOCK OR POULTRY DISEASES CONTROL OF...

  13. 9 CFR 166.6 - Swine feeding area standards.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Swine feeding area standards. 166.6... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.6 Swine feeding area standards. Untreated garbage shall not be allowed into swine feeding areas. Any equipment or...

  14. 9 CFR 166.6 - Swine feeding area standards.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Swine feeding area standards. 166.6... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.6 Swine feeding area standards. Untreated garbage shall not be allowed into swine feeding areas. Any equipment or...

  15. 9 CFR 166.6 - Swine feeding area standards.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Swine feeding area standards. 166.6... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.6 Swine feeding area standards. Untreated garbage shall not be allowed into swine feeding areas. Any equipment or...

  16. 9 CFR 166.6 - Swine feeding area standards.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Swine feeding area standards. 166.6... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.6 Swine feeding area standards. Untreated garbage shall not be allowed into swine feeding areas. Any equipment or...

  17. 9 CFR 166.6 - Swine feeding area standards.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Swine feeding area standards. 166.6... AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.6 Swine feeding area standards. Untreated garbage shall not be allowed into swine feeding areas. Any equipment or...

  18. 9 CFR 381.6 - Establishments requiring inspection.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Establishments requiring inspection. 381.6 Section 381.6 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... to section 5(c) of the Act as one producing adulterated poultry products which would clearly...

  19. 9 CFR 104.6 - Products for transit shipment only.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Products for transit shipment only. 104.6 Section 104.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS...

  20. 9 CFR 104.6 - Products for transit shipment only.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Products for transit shipment only. 104.6 Section 104.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS...

  1. 9 CFR 104.6 - Products for transit shipment only.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Products for transit shipment only. 104.6 Section 104.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS...

  2. 9 CFR 117.6 - Removal of animals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Removal of animals. 117.6 Section 117.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS ANIMALS AT LICENSED...

  3. 9 CFR 117.6 - Removal of animals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Removal of animals. 117.6 Section 117.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS ANIMALS AT LICENSED...

  4. 9 CFR 117.6 - Removal of animals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Removal of animals. 117.6 Section 117.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS ANIMALS AT LICENSED...

  5. 9 CFR 53.6 - Disinfection of animals.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Disinfection of animals. 53.6 Section 53.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... of animals. Animals of species not susceptible to the disease for which a quarantine has...

  6. 9 CFR 53.6 - Disinfection of animals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Disinfection of animals. 53.6 Section 53.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... of animals. Animals of species not susceptible to the disease for which a quarantine has...

  7. 9 CFR 53.6 - Disinfection of animals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Disinfection of animals. 53.6 Section 53.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... of animals. Animals of species not susceptible to the disease for which a quarantine has...

  8. 9 CFR 53.6 - Disinfection of animals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Disinfection of animals. 53.6 Section 53.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... of animals. Animals of species not susceptible to the disease for which a quarantine has...

  9. 9 CFR 53.6 - Disinfection of animals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Disinfection of animals. 53.6 Section 53.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF... of animals. Animals of species not susceptible to the disease for which a quarantine has...

  10. 9 CFR 117.6 - Removal of animals.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Removal of animals. 117.6 Section 117.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS ANIMALS AT LICENSED...

  11. 9 CFR 117.6 - Removal of animals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Removal of animals. 117.6 Section 117.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS ANIMALS AT LICENSED...

  12. 9 CFR 104.6 - Products for transit shipment only.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Products for transit shipment only. 104.6 Section 104.6 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS PERMITS...

  13. Singlet-triplet energy splitting between 1D and 3D (1s2 2s nd), n = 3, 4, 5, and 6, Rydberg states of the beryllium atom (9Be) calculated with all-electron explicitly correlated Gaussian functions

    NASA Astrophysics Data System (ADS)

    Sharkey, Keeper L.; Bubin, Sergiy; Adamowicz, Ludwik

    2014-11-01

    Accurate variational nonrelativistic quantum-mechanical calculations are performed for the five lowest 1D and four lowest 3D states of the 9Be isotope of the beryllium atom. All-electron explicitly correlated Gaussian (ECG) functions are used in the calculations and their nonlinear parameters are optimized with the aid of the analytical energy gradient determined with respect to these parameters. The effect of the finite nuclear mass is directly included in the Hamiltonian used in the calculations. The singlet-triplet energy gaps between the corresponding 1D and 3D states, are reported.

  14. Pressure-induced isomerization of a heterometallic rhodium-gold cluster compound: (Rh sub 2 (. mu. -Cl) sub 2 (CNC sub 8 H sub 9 ) sub 4 (. mu. -AuPPh sub 3 )) sub 2 (PF sub 6 ) sub 2

    SciTech Connect

    Bray, K.L.; Drickamer, H.G.; Shapley, J.R. ); Mingos, D.M.P.; Watson, M.J. )

    1991-02-20

    Mingos et al. have prepared two isomers of the cluster compound (Rh{sub 2}(mu-Cl{sub 2})(CNC{sub 8}H{sub 9}){sub 4}(mu-AuPPh{sub 3})){sub 2}(PF{sub 6}){sub 2} and have characterized these isomers using single crystal x-ray techniques. The volumes per cluster cation were found to be very similar for both isomers, 1,430 and 1,413 angstroms, and the Rh-Rh bond lengths were found to be 3.262 and 3.008 angstroms for the same isomer. The cluster skeletal geometries were found to differ only at an interior link, and applied pressure appeared to induce a conformational transition around this bond.

  15. Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity

    PubMed Central

    Al-Majedy, Yasameen K.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar

    2016-01-01

    The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity. PMID:27563671

  16. First Ground-Based Infrared Solar Absorption Measurements of Free Tropospheric Methanol (CH3OH): Multidecade Infrared Time Series from Kitt Peak (31.9 deg N 111.6 deg W): Trend, Seasonal Cycle, and Comparison with Previous Measurements

    NASA Technical Reports Server (NTRS)

    Rinsland, Curtis P.; Mahieu, Emmanuel; Chiou, Linda; Herbin, Herve

    2009-01-01

    Atmospheric CH3OH (methanol) free tropospheric (2.09-14-km altitude) time series spanning 22 years has been analyzed on the basis of high-spectral resolution infrared solar absorption spectra of the strong vs band recorded from the U.S. National Solar Observatory on Kitt Peak (latitude 31.9degN, 111.6degW, 2.09-km altitude) with a 1-m Fourier transform spectrometer (FTS). The measurements span October 1981 to December 2003 and are the first long time series of CH3OH measurements obtained from the ground. The results were analyzed with SFIT2 version 3.93 and show a factor of three variations with season, a maximum at the beginning of July, a winter minimum, and no statistically significant long-term trend over the measurement time span.

  17. First Ground-Based Infrared Solar Absorption Measurements of Free Tropospheric Methanol (CH3OH): Multidecade Infrared Time Series from Kitt Peak (31.9 deg N 111.6 deg W): Trend, Seasonal Cycle, and Comparison with Previous Measurements

    NASA Technical Reports Server (NTRS)

    Rinsland, Curtis P.; Mahieu, Emmanuel; Chiou, Linda; Herbin, Herve

    2009-01-01

    Atmospheric CH3OH (methanol) free tropospheric (2.09-14-km altitude) time series spanning 22 years has been analyzed on the basis of high-spectral resolution infrared solar absorption spectra of the strong n8 band recorded from the U.S. National Solar Observatory on Kitt Peak (latitude 31.9degN, 111.6degW, 2.09-km altitude) with a 1-m Fourier transform spectrometer (FTS). The measurements span October 1981 to December 2003 and are the first long time series of CH3OH measurements obtained from the ground. The results were analyzed with SFIT2 version 3.93 and show a factor of three variations with season, a maximum at the beginning of July, a winter minimum, and no statistically significant long-term trend over the measurement time span.

  18. Efficient Catalyst One-Pot Synthesis of 7-(Aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione Derivatives Complemented by Antibacterial Activity.

    PubMed

    Al-Majedy, Yasameen K; Al-Amiery, Ahmed A; Kadhum, Abdul Amir H; Mohamad, Abu Bakar

    2016-01-01

    The problem of bacteria resistance to many known agents has inspired scientists and researchers to discover novel efficient antibacterial drugs. Three rapid, clean, and highly efficient methods were developed for one-pot synthesis of 7-(aryl)-10,10-dimethyl-10,11-dihydrochromeno[4,3-b]chromene-6,8(7H,9H)-dione derivatives. Three components are condensed in the synthesis, 4-hydroxycoumarin, 5,5-dimethyl-1,3-cyclohexanedione, and aromatic aldehydes, using tetrabutylammonium bromide (TBAB), diammonium hydrogen phosphate (DAHP), or ferric chloride (FeCl3), respectively. Each method has different reaction mechanisms according to the catalyst. The present methods have advantages, including one-pot synthesis, excellent yields, short reaction times, and easy isolation of product. All catalysts utilized in our study could be reused several times without losing their catalytic efficiency. All synthesized compounds were fully characterized and evaluated for their antibacterial activity. PMID:27563671

  19. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Initiallicense fee Annual orchanged class of license fee $0 $500 $30 $40 500 2,000 60 70 2,000 10,000 120 130 10... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Annual license fees. 2.6 Section 2.6... WELFARE REGULATIONS Licensing § 2.6 Annual license fees. (a) For an initial license, the applicant...

  20. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Initiallicense fee Annual orchanged class of license fee $0 $500 $30 $40 500 2,000 60 70 2,000 10,000 120 130 10... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Annual license fees. 2.6 Section 2.6... WELFARE REGULATIONS Licensing § 2.6 Annual license fees. (a) For an initial license, the applicant...

  1. 9 CFR 2.6 - Annual license fees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Initiallicense fee Annual orchanged class of license fee $0 $500 $30 $40 500 2,000 60 70 2,000 10,000 120 130 10... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Annual license fees. 2.6 Section 2.6... WELFARE REGULATIONS Licensing § 2.6 Annual license fees. (a) For an initial license, the applicant...

  2. 9-Benzyl-3-bromo-9H-carbazole

    PubMed Central

    Huang, Peng-Mian; Wang, Xiao-Chun

    2009-01-01

    The title compound, C19H14BrN, was synthesized by the N-alkyl­ation of (chloro­meth­yl)benzene with 3-bromo-9H-carbazole. The carbazole ring system is essentially planar (r.m.s. deviation = 0.013 Å) and forms a dihedral angle of 87.1 (2)° with the phenyl ring. PMID:21583473

  3. Translational, vibrational, rotational enhancements and alignments of reactions H + ClF (v = 0-5, j = 0,3,6,9) → HCl + F and HF + Cl, at Erel = 0.5-20 kcal/mol

    NASA Astrophysics Data System (ADS)

    Victor Wei-Keh, Chao(Wu

    2013-10-01

    Quasi-classical trajectory calculations of the title reactions H + ClF (v = 0-5, j = 0,3,6,9) → HCl + F and H + ClF (v = 0-5, j = 0,3,6,9) → HF + Cl at Erel = 0.5 kcal/mol-20 kcal/mol on ground potential energy surface DHTSN of 1 2A' [M. P. Deskevich, M. Y. Hayes, K. Takahashi, R. T. Skodje and D. J. Nesbitt, J. Chem. Phys. 124, 224303 (2006)] are performed. Potential energy surfaces derived from DHTSN for the title reactions are obtained, and compared with that of DHTSN for the reaction F + HCl → HF + Cl. Both potential energy surfaces have an early barrier pattern. Integral cross sections and alignments of product molecules HCl and HF dependent on the internal energy states v and j of reactant molecule ClF are obtained and compared. Translational, vibrational, and rotational energy specific translational enhancements of the reactant molecule ClF of the title reactions are found. Reaction mechanisms of the title reactions according to the respective potential energy contours are further found and explained. Reasons of simultaneous translational and vibrational enhancements are clarified.

  4. Final report on the safety assessment of octoxynol-1, octoxynol-3, octoxynol-5, octoxynol-6, octoxynol-7, octoxynol-8, octoxynol-9, octoxynol-10, octoxynol-11, octoxynol-12, octoxynol-13, octoxynol-16, octoxynol-20, octoxynol-25, octoxynol-30, octoxynol-33, octoxynol-40, octoxynol-70, octoxynol-9 carboxylic acid, octoxynol-20 carboxylic acid, potassium octoxynol-12 phosphate, sodium octoxynol-2 ethane sulfonate, sodium octoxynol-2 sulfate, sodium octoxynol-6 sulfate, and sodium octoxynol-9 sulfate.

    PubMed

    Johnson, Wilbur

    2004-01-01

    autoimmune response in mice. In the Ames test, Octoxynol-1 was not mutagenic with and without metabolic activation nor was Octoxynol-9 clastogenic. Results for Octoxynol-9 were negative in the following assays: unscheduled DNA synthesis, hypoxanthine guanine phosphoribosyl transferase mutation assay, malignant transformation assay, DNA alkaline unwinding test, and mouse lymphoma thymidine kinase locus forward mutation assay. Ethoxylated alkylphenols are generally considered to be estrogenic in that they mimic the effects of estradiol. Dermal exposure at three dose levels of rats to Octoxynol-9 failed to induce any malformations by category (external, visceral, or skeletal) or by individual anatomical location that were different from controls at statistically significant level. An increased incidence of a vestigial thoracic rib was observed in all dose groups. Octoxynol-9 also did not induce developmental toxicity (number of viable litters, liveborn per litter, percentage survival, birth weight per pup, and weight gain per pup) in female specific pathogen-free CD-1 mice dosed daily by gavage on gestation days 6 through 13. No reproductive toxicity was seen in male albino rats which received 5% Octoxynol-40 in the diet daily for 3 months; however, in an in vitro test, Octoxynol-9 (0.24 mg/ml) totally immobilized all human spermatozoa within 20 s. Women who used Nonoxynol-9 or Octoxynol-9 as spermicides, but who did become pregnant, did not have an increase in the overall risk of fetal malformations. In a human skin irritation study, formulations containing 2.0% Octoxynol-9 were classified as moderately irritating and minimally irritating, respectively, in a 24-h single-insult, occlusive patch test. Octoxynol-9 (1.0%) was classified as a nonirritant in a clinical study of nine subjects patch tested for 4 consecutive days. The skin sensitization potential of Octoxynols-1, -3, -5, -9, and -13 was evaluated using 50 subjects. Octoxynol-1 induced sensitization in two subjects; all

  5. THE INFRARED SPECTRA OF POLYCYCLIC AROMATIC HYDROCARBONS WITH EXCESS PERIPHERAL H ATOMS (H {sub n} -PAHs) AND THEIR RELATION TO THE 3.4 AND 6.9 {mu}m PAH EMISSION FEATURES

    SciTech Connect

    Sandford, Scott A.; Bernstein, Max P.; Materese, Christopher K.

    2013-03-01

    Polycyclic aromatic hydrocarbons (PAHs) are likely responsible for the family of infrared emission features seen in a wide variety of astrophysical environments. A potentially important subclass of these materials are PAHs whose edges contain excess H atoms (H {sub n} -PAHs). This type of compound may be present in space, but it has been difficult to assess this possibility because of a lack of suitable laboratory spectra to assist with analysis of astronomical data. We present 4000-500 cm{sup -1} (2.5-20 {mu}m) infrared spectra of 23 H {sub n} -PAHs and related molecules isolated in argon matrices under conditions suitable for interpretation of astronomical data. Spectra of molecules with mixed aromatic and aliphatic domains show characteristics that distinguish them from fully aromatic PAH equivalents. Two major changes occur as PAHs become more hydrogenated: (1) aromatic C-H stretching bands near 3.3 {mu}m weaken and are replaced with stronger aliphatic bands near 3.4 {mu}m, and (2) aromatic C-H out-of-plane bending mode bands in the 11-15 {mu}m region shift and weaken concurrent with growth of a strong aliphatic -CH{sub 2}- deformation mode near 6.9 {mu}m. Implications for interpreting astronomical spectra are discussed with emphasis on the 3.4 and 6.9 {mu}m features. Laboratory data is compared with emission spectra from IRAS 21282+5050, an object with normal PAH emission features, and IRAS 22272+5435 and IRAS 0496+3429, two protoplanetary nebulae with abnormally large 3.4 {mu}m features. We show that 'normal' PAH emission objects contain relatively few H {sub n} -PAHs in their emitter populations, but less evolved protoplanetary nebulae may contain significant abundances of these molecules.

  6. The Infrared Spectra of Polycyclic Aromatic Hydrocarbons with Excess Peripheral H Atoms (Hn-PAHs) and their Relation to the 3.4 and 6.9 µm PAH Emission Features

    PubMed Central

    Sandford, Scott A.; Bernstein, Max P.; Materese, Christopher K.

    2015-01-01

    Polycyclic aromatic hydrocarbons (PAHs) are likely responsible for the family of infrared emission features seen in a wide variety of astrophysical environments. A potentially important subclass of these materials are PAHs whose edges contain excess H atoms (Hn-PAHs). This type of compound may be present in space, but it has been difficult to assess this possibility because of a lack of suitable laboratory spectra to assist with analysis of astronomical data. We present 4000-500 cm−1 (2.5–20 µm) infrared spectra of 23 Hn-PAHs and related molecules isolated in argon matrices under conditions suitable for interpretation of astronomical data. Spectra of molecules with mixed aromatic and aliphatic domains show characteristics that distinguish them from fully aromatic PAH equivalents. Two major changes occur as PAHs become more hydrogenated: (1) aromatic C-H stretching bands near 3.3 µm weaken and are replaced with stronger aliphatic bands near 3.4 µm, and (2) aromatic C-H out-of-plane bending mode bands in the 11–15 µm region shift and weaken concurrent with growth of a strong aliphatic -CH2-deformation mode near 6.9 µm. Implications for interpreting astronomical spectra are discussed with emphasis on the 3.4 and 6.9 µm features. Laboratory data is compared with emission spectra from IRAS 21282+5050, an object with normal PAH emission features, and IRAS 22272+5435 and IRAS 0496+3429, two protoplanetary nebulae with abnormally large 3.4 µm features. We show that ‘normal’ PAH emission objects contain relatively few Hn-PAHs in their emitter populations, but less evolved protoplanetary nebulae may contain significant abundances of these molecules. PMID:26435553

  7. Crystal structure of (1R,3S,8R,11R)-11-acetyl-3,7,7-trimethyl-10-oxatri­cyclo­[6.4.0.01,3]dodecan-9-one

    PubMed Central

    Bismoussa, Abdoullah; Ait Itto, My Youssef; Daran, Jean-Claude; Auhmani, Abdelwahed; Auhmani, Aziz

    2015-01-01

    The title compound, C16H24O3, is built up from three fused rings, a six-membered, a seven-membered and a three-membered ring. The absolute configuration of the title compound was determined as (1R,3S,8R,11R) based on the synthetic pathway. The six-membered ring has an half-chair conformation whereas the seven-membered ring displays a boat conformation. In the cyrstal, C—H⋯O hydrogen bonds build up a two-dimensional network parallel to (0 0 1). The crystal studied was an inversion twin with a minor twin component of 34%. PMID:26870471

  8. Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides

    SciTech Connect

    Singh, Satyender; Kumar, Vivek; Vashisht, Kapil; Singh, Priyanka; Banerjee, Basu Dev; Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen; Jain, Sudhir Kumar; Rai, Arvind

    2011-11-15

    Organophosphate pesticides (OPs) are primarily metabolized by several xenobiotic metabolizing enzymes (XMEs). Very few studies have explored genetic polymorphisms of XMEs and their association with DNA damage in pesticide-exposed workers. The present study was designed to determine the role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to OPs. We examined 284 subjects including 150 workers occupationally exposed to OPs and 134 normal healthy controls. The DNA damage was evaluated using the alkaline comet assay and genotyping was done using PCR-RFLP. The results revealed that the PONase activity toward paraoxonase and AChE activity was found significantly lowered in workers as compared to control subjects (p < 0.001). Workers showed significantly higher DNA damage compared to control subjects (14.37 {+-} 2.15 vs. 6.24 {+-} 1.37 tail% DNA, p < 0.001). Further, the workers with CYP2D6*3 PM and PON1 (QQ and MM) genotypes were found to have significantly higher DNA damage when compared to other genotypes (p < 0.05). In addition, significant increase in DNA damage was also observed in workers with concomitant presence of certain CYP2D6 and PON1 (Q192R and L55M) genotypes which need further extensive studies. In conclusion, the results indicate that the PON1 and CYP2D6 genotypes can modulate DNA damage elicited by some OPs possibly through gene-environment interactions. -- Highlights: Black-Right-Pointing-Pointer Role of CYP1A1, CYP3A5, CYP2C, CYP2D6 and PON1 genotypes on DNA damage. Black-Right-Pointing-Pointer Workers exposed to some OPs demonstrated increased DNA damage. Black-Right-Pointing-Pointer CYP2D6 *3 PM and PON1 (Q192R and L55M) genotypes are associated with DNA damage. Black-Right-Pointing-Pointer Concomitant presence of certain CYP2D6 and PON1 genotypes can increase DNA damage.

  9. 9 CFR 3.92 - Handling.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... regulations (9 CFR parts 1, 2, and 3) who moves (including loading and unloading) nonhuman primates within, to...: (1) Shelter from sunlight and extreme heat. Sufficient shade must be provided to protect the...

  10. 9 CFR 3.92 - Handling.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... regulations (9 CFR parts 1, 2, and 3) who moves (including loading and unloading) nonhuman primates within, to...: (1) Shelter from sunlight and extreme heat. Sufficient shade must be provided to protect the...

  11. 9 CFR 3.92 - Handling.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... regulations (9 CFR parts 1, 2, and 3) who moves (including loading and unloading) nonhuman primates within, to...: (1) Shelter from sunlight and extreme heat. Sufficient shade must be provided to protect the...

  12. New polymorphs of Ru{sup III}P{sub 3}O{sub 9}: Cyclo-hexaphosphate Ru{sub 2}P{sub 6}O{sub 18} and metaphosphate Ru(PO{sub 3}){sub 3} with a novel structure

    SciTech Connect

    Fukuoka, Hiroshi; Imoto, Hideo; Saito, Taro

    1995-10-01

    Two new polymorphs of ruthenium phosphate with RuP{sub 3}O{sub 9} composition were prepared and their crystal structures were determined by single-crystal X-ray diffraction. They are cyclo-hexaphosphate Ru{sub 2}P{sub 6}O{sub 18} and metaphosphate Ru(PO{sub 3}){sub 3}. Ru{sub 2}P{sub 6}O{sub 18} crystallizes in the monoclinic space group P2{sub 1}/c with a = 6.292(2) {angstrom}, b = 15.276(2) {angstrom}, c = 8.365(2) {angstrom}, {beta} = 106.54(2){degrees}, contains cyclo-hexaphosphate rings stacking obliquely along the [100] direction and is isotypic with B-form cyclo-phosphates. Ru(PO{sub 3}){sub 3} has a novel structure and crystallizes in the triclinic space group P1 with a = 6.957(1) {angstrom}, b = 10.324(2) {angstrom},c = 5.030(1) {angstrom}, {alpha} = 92.45(2){degrees}, {beta} = 92.31(2){degrees}, {gamma} = 98.61(1){degrees}, V = 356.5(1) {angstrom}{sup 3}, [PO{sub 3}{sup -}]{sub {infinity}} chains is different from that in the C-form Ru(PO{sub 3}){sub 3}. While the chains in the C-form consisting of PO{sub 3}-O-PO{sub 3} units are condensed in nearly staggered configurations, the units in the new phosphate are eclipsed.

  13. 9 CFR 201.3 - Authority.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Authority. 201.3 Section 201.3 Animals and Animal Products GRAIN INSPECTION, PACKERS AND STOCKYARDS ADMINISTRATION (PACKERS AND STOCKYARDS....3 Authority. The Administrator shall perform such duties as the Secretary may require in...

  14. 9 CFR 3.106 - Water quality.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Water quality. 3.106 Section 3.106... Mammals Animal Health and Husbandry Standards § 3.106 Water quality. (a) General. The primary enclosure shall not contain water which would be detrimental to the health of the marine mammal contained...

  15. 9 CFR 3.106 - Water quality.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Water quality. 3.106 Section 3.106... Mammals Animal Health and Husbandry Standards § 3.106 Water quality. (a) General. The primary enclosure shall not contain water which would be detrimental to the health of the marine mammal contained...

  16. 9 CFR 3.106 - Water quality.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Water quality. 3.106 Section 3.106... Mammals Animal Health and Husbandry Standards § 3.106 Water quality. (a) General. The primary enclosure shall not contain water which would be detrimental to the health of the marine mammal contained...

  17. 9 CFR 3.106 - Water quality.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Water quality. 3.106 Section 3.106... Mammals Animal Health and Husbandry Standards § 3.106 Water quality. (a) General. The primary enclosure shall not contain water which would be detrimental to the health of the marine mammal contained...

  18. 9 CFR 3.106 - Water quality.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Water quality. 3.106 Section 3.106... Mammals Animal Health and Husbandry Standards § 3.106 Water quality. (a) General. The primary enclosure shall not contain water which would be detrimental to the health of the marine mammal contained...

  19. 9 CFR 3.50 - Facilities, general.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Facilities, general. 3.50 Section 3.50 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Facilities and Operating Standards § 3.50 Facilities, general. (a) Structural strength. Indoor and...

  20. 9 CFR 3.50 - Facilities, general.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Facilities, general. 3.50 Section 3.50 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Facilities and Operating Standards § 3.50 Facilities, general. (a) Structural strength. Indoor and...

  1. 9 CFR 3.50 - Facilities, general.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Facilities, general. 3.50 Section 3.50 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Facilities and Operating Standards § 3.50 Facilities, general. (a) Structural strength. Indoor and...

  2. 9 CFR 3.50 - Facilities, general.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Facilities, general. 3.50 Section 3.50 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Facilities and Operating Standards § 3.50 Facilities, general. (a) Structural strength. Indoor and...

  3. 9 CFR 3.128 - Space requirements.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Space requirements. 3.128 Section 3... Mammals Facilities and Operating Standards § 3.128 Space requirements. Enclosures shall be constructed and maintained so as to provide sufficient space to allow each animal to make normal postural and...

  4. 9 CFR 3.133 - Separation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Separation. 3.133 Section 3.133 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.133 Separation. Animals housed in the same...

  5. 9 CFR 3.133 - Separation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Separation. 3.133 Section 3.133 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.133 Separation. Animals housed in the same...

  6. 9 CFR 3.133 - Separation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Separation. 3.133 Section 3.133 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.133 Separation. Animals housed in the same...

  7. 9 CFR 3.133 - Separation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Separation. 3.133 Section 3.133 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.133 Separation. Animals housed in the same...

  8. 9 CFR 3.133 - Separation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Separation. 3.133 Section 3.133 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.133 Separation. Animals housed in the same...

  9. 9 CFR 116.3 - Label records.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    .... Each label shall be identified as to: (1) Name and product code number as it appears on the product... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Label records. 116.3 Section 116.3..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.3 Label...

  10. 9 CFR 116.3 - Label records.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    .... Each label shall be identified as to: (1) Name and product code number as it appears on the product... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Label records. 116.3 Section 116.3..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.3 Label...

  11. 9 CFR 116.3 - Label records.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    .... Each label shall be identified as to: (1) Name and product code number as it appears on the product... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Label records. 116.3 Section 116.3..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.3 Label...

  12. 9 CFR 116.3 - Label records.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    .... Each label shall be identified as to: (1) Name and product code number as it appears on the product... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Label records. 116.3 Section 116.3..., SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.3 Label...

  13. 9 CFR 3.82 - Feeding.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Feeding. 3.82 Section 3.82 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE... Animal Health and Husbandry Standards § 3.82 Feeding. (a) The diet for nonhuman primates must...

  14. 9 CFR 3.51 - Facilities, indoor.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Facilities, indoor. 3.51 Section 3.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Facilities and Operating Standards § 3.51 Facilities, indoor. (a) Heating. Indoor housing facilities...

  15. 9 CFR 392.3 - Required information.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Required information. 392.3 Section 392.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.3...

  16. 9 CFR 392.3 - Required information.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 2 2011-01-01 2011-01-01 false Required information. 392.3 Section 392.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.3...

  17. 9 CFR 392.3 - Required information.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Required information. 392.3 Section 392.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.3...

  18. 9 CFR 392.3 - Required information.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false Required information. 392.3 Section 392.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.3...

  19. 9 CFR 3.83 - Watering.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Watering. 3.83 Section 3.83 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Primates 2 Animal Health and Husbandry Standards § 3.83 Watering. Potable water must be provided...

  20. 9 CFR 3.32 - Employees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Employees. 3.32 Section 3.32 Animals... Pigs and Hamsters Animal Health and Husbandry Standards § 3.32 Employees. A sufficient number of employees shall be utilized to maintain the prescribed level of husbandry practices set forth in...

  1. 9 CFR 3.110 - Veterinary care.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Veterinary care. 3.110 Section 3.110 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.110 Veterinary care. (a) Newly acquired marine...

  2. 9 CFR 3.110 - Veterinary care.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Veterinary care. 3.110 Section 3.110 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.110 Veterinary care. (a) Newly acquired marine...

  3. 9 CFR 3.110 - Veterinary care.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Veterinary care. 3.110 Section 3.110 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.110 Veterinary care. (a) Newly acquired marine...

  4. 9 CFR 3.110 - Veterinary care.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Veterinary care. 3.110 Section 3.110 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.110 Veterinary care. (a) Newly acquired marine...

  5. 9 CFR 3.110 - Veterinary care.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Veterinary care. 3.110 Section 3.110 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL... Mammals Animal Health and Husbandry Standards § 3.110 Veterinary care. (a) Newly acquired marine...

  6. 9 CFR 145.3 - Participation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.3... 9-2 (formerly NPIP Form 3B) or through other appropriate means each breeding flock before the birds... designation; (3) Type: Primary or Multiplier; (4) Breed, variety, strain, or trade name of stock; (5)...

  7. 9 CFR 145.3 - Participation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.3... 9-2 (formerly NPIP Form 3B) or through other appropriate means each breeding flock before the birds... designation; (3) Type: Primary or Multiplier; (4) Breed, variety, strain, or trade name of stock; (5)...

  8. 9 CFR 145.3 - Participation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR BREEDING POULTRY General Provisions § 145.3... 9-2 (formerly NPIP Form 3B) or through other appropriate means each breeding flock before the birds... designation; (3) Type: Primary or Multiplier; (4) Breed, variety, strain, or trade name of stock; (5)...

  9. 9 CFR 3.128 - Space requirements.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Space requirements. 3.128 Section 3... Mammals Facilities and Operating Standards § 3.128 Space requirements. Enclosures shall be constructed and maintained so as to provide sufficient space to allow each animal to make normal postural and...

  10. 9 CFR 3.128 - Space requirements.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Space requirements. 3.128 Section 3... Mammals Facilities and Operating Standards § 3.128 Space requirements. Enclosures shall be constructed and maintained so as to provide sufficient space to allow each animal to make normal postural and...

  11. 9 CFR 3.128 - Space requirements.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Space requirements. 3.128 Section 3... Mammals Facilities and Operating Standards § 3.128 Space requirements. Enclosures shall be constructed and maintained so as to provide sufficient space to allow each animal to make normal postural and...

  12. 9 CFR 116.3 - Label records.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Label records. 116.3 Section 116.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE VIRUSES, SERUMS, TOXINS, AND ANALOGOUS PRODUCTS; ORGANISMS AND VECTORS RECORDS AND REPORTS § 116.3 Label records. (a) Each licensee and permittee...

  13. 9 CFR 392.3 - Required information.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Required information. 392.3 Section 392.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE FOOD SAFETY AND INSPECTION SERVICE ADMINISTRATIVE PROVISIONS PETITIONS FOR RULEMAKING § 392.3...

  14. 9 CFR 3.128 - Space requirements.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Space requirements. 3.128 Section 3... Mammals Facilities and Operating Standards § 3.128 Space requirements. Enclosures shall be constructed and maintained so as to provide sufficient space to allow each animal to make normal postural and...

  15. Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides.

    PubMed

    Singh, Satyender; Kumar, Vivek; Vashisht, Kapil; Singh, Priyanka; Banerjee, Basu Dev; Rautela, Rajender Singh; Grover, Shyam Sunder; Rawat, Devendra Singh; Pasha, Syed Tazeen; Jain, Sudhir Kumar; Rai, Arvind

    2011-11-15

    Organophosphate pesticides (OPs) are primarily metabolized by several xenobiotic metabolizing enzymes (XMEs). Very few studies have explored genetic polymorphisms of XMEs and their association with DNA damage in pesticide-exposed workers. The present study was designed to determine the role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to OPs. We examined 284 subjects including 150 workers occupationally exposed to OPs and 134 normal healthy controls. The DNA damage was evaluated using the alkaline comet assay and genotyping was done using PCR-RFLP. The results revealed that the PONase activity toward paraoxonase and AChE activity was found significantly lowered in workers as compared to control subjects (p<0.001). Workers showed significantly higher DNA damage compared to control subjects (14.37±2.15 vs. 6.24±1.37 tail% DNA, p<0.001). Further, the workers with CYP2D6*3PM and PON1 (QQ and MM) genotypes were found to have significantly higher DNA damage when compared to other genotypes (p<0.05). In addition, significant increase in DNA damage was also observed in workers with concomitant presence of certain CYP2D6 and PON1 (Q192R and L55M) genotypes which need further extensive studies. In conclusion, the results indicate that the PON1 and CYP2D6 genotypes can modulate DNA damage elicited by some OPs possibly through gene-environment interactions. PMID:21907728

  16. A boundary-representation method for designing whole-body radiation dosimetry models: pregnant females at the ends of three gestational periods—RPI-P3, -P6 and -P9

    NASA Astrophysics Data System (ADS)

    Xu, X. George; Taranenko, Valery; Zhang, Juying; Shi, Chengyu

    2007-12-01

    Fetuses are extremely radiosensitive and the protection of pregnant females against ionizing radiation is of particular interest in many health and medical physics applications. Existing models of pregnant females relied on simplified anatomical shapes or partial-body images of low resolutions. This paper reviews two general types of solid geometry modeling: constructive solid geometry (CSG) and boundary representation (BREP). It presents in detail a project to adopt the BREP modeling approach to systematically design whole-body radiation dosimetry models: a pregnant female and her fetus at the ends of three gestational periods of 3, 6 and 9 months. Based on previously published CT images of a 7-month pregnant female, the VIP-Man model and mesh organ models, this new set of pregnant female models was constructed using 3D surface modeling technologies instead of voxels. The organ masses were adjusted to agree with the reference data provided by the International Commission on Radiological Protection (ICRP) and previously published papers within 0.5%. The models were then voxelized for the purpose of performing dose calculations in identically implemented EGS4 and MCNPX Monte Carlo codes. The agreements of the fetal doses obtained from these two codes for this set of models were found to be within 2% for the majority of the external photon irradiation geometries of AP, PA, LAT, ROT and ISO at various energies. It is concluded that the so-called RPI-P3, RPI-P6 and RPI-P9 models have been reliably defined for Monte Carlo calculations. The paper also discusses the needs for future research and the possibility for the BREP method to become a major tool in the anatomical modeling for radiation dosimetry.

  17. 32 CFR 9.6 - Conduct of the trial.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.6... shall exercise these powers on behalf of the Commission at the Presiding Officer's own initiative, or at... Presiding Officer may decide to close all or part of a proceeding on the Presiding Officer's own...

  18. 32 CFR 9.6 - Conduct of the trial.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... TRIALS BY MILITARY COMMISSIONS OF CERTAIN NON-UNITED STATES CITIZENS IN THE WAR AGAINST TERRORISM § 9.6... shall exercise these powers on behalf of the Commission at the Presiding Officer's own initiative, or at... Presiding Officer may decide to close all or part of a proceeding on the Presiding Officer's own...

  19. Sea Turtles: An Auditorium Program, Grades 6-9.

    ERIC Educational Resources Information Center

    National Aquarium in Baltimore, MD. Dept. of Education.

    The National Aquarium in Baltimore's sea turtle auditorium program introduces students in grades 6-9 to the seven (or eight, depending on which expert is consulted) species of sea turtles alive today. The program, which includes slides, films, artifacts, and discussion, focuses on sea turtle biology and conservation. This booklet covers most of…

  20. 44 CFR 9.6 - Decision-making process.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.6 Decision-making process. (a) Purpose. The purpose of this section is to set out the floodplain management and wetlands... the decision-making process was initially designed to address the floodplain Order's requirements,...

  1. 44 CFR 9.6 - Decision-making process.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.6 Decision-making process. (a) Purpose. The purpose of this section is to set out the floodplain management and wetlands... the decision-making process was initially designed to address the floodplain Order's requirements,...

  2. 44 CFR 9.6 - Decision-making process.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.6 Decision-making process. (a) Purpose. The purpose of this section is to set out the floodplain management and wetlands... the decision-making process was initially designed to address the floodplain Order's requirements,...

  3. 44 CFR 9.6 - Decision-making process.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.6 Decision-making process. (a) Purpose. The purpose of this section is to set out the floodplain management and wetlands... the decision-making process was initially designed to address the floodplain Order's requirements,...

  4. 44 CFR 9.6 - Decision-making process.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... HOMELAND SECURITY GENERAL FLOODPLAIN MANAGEMENT AND PROTECTION OF WETLANDS § 9.6 Decision-making process. (a) Purpose. The purpose of this section is to set out the floodplain management and wetlands... the decision-making process was initially designed to address the floodplain Order's requirements,...

  5. Synthesis of 6-Methyl-9-n-propyldibenzothiophene-4-ol

    SciTech Connect

    Eisenbraun, E.J.

    1991-07-25

    The material covered in this report is divided into two parts: further cyclization experiments on 1,4-diethyl-2-[(2'- methoxyphenyl)thio]benzene and its sulfone both by chemical and photochemical means, and progress toward synthesis of modified target molecule, 9-isopropyl-4-methoxy-6-methyldibenzo-thiophene. 8 refs, figs.

  6. 6-(4-Methyl­phen­yl)-2,10-dioxo-3,9-dioxa-6-aza-1(1,1′)-ferrocenacyclo­deca­phane

    PubMed Central

    Leng, Xin; Yang, Bingqin; Cui, Lin; Liu, Bo

    2010-01-01

    In the title compound, [Fe(C23H23NO4)], the two cyclo­penta­dienyl (Cp) rings are nearly parallel, with a dihedral angle of 2.1 (1)°. The distance between the centroids of the Cp rings is 3.277 (8) Å. The relative orientation of the two Cp rings is characterized by a torsion angle of −64.3 (3)° defined by the two centroids and two substituted atoms. PMID:21589228

  7. 3. This series of photographs (3 through 9) illustrates the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. This series of photographs (3 through 9) illustrates the operation of the swing bridge. In #3 the bridge is in its closed position. #3 4,5,&6 the boat whistles and requests passage. the bridge is closed to traffice. The bridge operator, stationed in the center of the tenders house at the center of the truss releases the pneumatic jack. The rollers beneath the deck. swing upward and the electric-powered turntable swings the bobtail drawn in the direction of the oncoming vessel. In #7 a tugboat enters the channel. In #8 a much-lightened ore carrier which has delivered its cargo to the steel mills upriver(note the high water mark), makes its way down-river towards Lake Erie. Such boats are too large to turn around on the narrow Cuyahoga, so they go out backwards, pulled by a tug. in #9 the the ore-carrier clears the channel. In #10 As soon as the boat clears the bridge, the bridge tender begins to close it. The bridge is opened in the direction of an oncoming vessel so that it can be closed even as the boat is leaving the channel; thus surface traffic on Center Street suffers the least possible interruption. - Center Street Swing Bridge, Southwest of Public Square, Cleveland, Cuyahoga County, OH

  8. 9 CFR 82.3 - Quarantined areas.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Quarantined areas. 82.3 Section 82.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS EXOTIC NEWCASTLE DIS- EASE...

  9. 9 CFR 82.3 - Quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Quarantined areas. 82.3 Section 82.3 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE INTERSTATE TRANSPORTATION OF ANIMALS (INCLUDING POULTRY) AND ANIMAL PRODUCTS EXOTIC NEWCASTLE DIS- EASE...

  10. 9 CFR 3.129 - Feeding.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Feeding. 3.129 Section 3.129 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Warmblooded Animals Other Than Dogs, Cats,...

  11. 47 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.3... VoIP service. An interconnected Voice over Internet protocol (VoIP) service is a service that: (1... location; (3) Requires Internet protocol-compatible customer premises equipment (CPE); and (4)...

  12. 47 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.3... VoIP service. An interconnected Voice over Internet protocol (VoIP) service is a service that: (1... location; (3) Requires Internet protocol-compatible customer premises equipment (CPE); and (4)...

  13. 47 CFR 9.3 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... FEDERAL COMMUNICATIONS COMMISSION GENERAL INTERCONNECTED VOICE OVER INTERNET PROTOCOL SERVICES § 9.3... VoIP service. An interconnected Voice over Internet protocol (VoIP) service is a service that: (1... location; (3) Requires Internet protocol-compatible customer premises equipment (CPE); and (4)...

  14. 9 CFR 300.3 - FSIS organization.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 2 2014-01-01 2014-01-01 false FSIS organization. 300.3 Section 300.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION AGENCY MISSION AND...

  15. 9 CFR 300.3 - FSIS organization.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false FSIS organization. 300.3 Section 300.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY ORGANIZATION AND TERMINOLOGY; MANDATORY MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION AGENCY MISSION AND...

  16. 9 CFR 3.32 - Employees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Employees. 3.32 Section 3.32 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of...

  17. 9 CFR 3.83 - Watering.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Watering. 3.83 Section 3.83 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of...

  18. 9 CFR 3.132 - Employees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Employees. 3.132 Section 3.132 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Warmblooded Animals Other Than Dogs, Cats,...

  19. 9 CFR 3.126 - Facilities, indoor.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Facilities, indoor. 3.126 Section 3.126 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... ambient temperature shall not be allowed to fall below nor rise above temperatures compatible with...

  20. 9 CFR 3.55 - Watering.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Watering. 3.55 Section 3.55 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of...

  1. 9 CFR 3.55 - Watering.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Watering. 3.55 Section 3.55 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of...

  2. 9 CFR 3.57 - Employees.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Employees. 3.57 Section 3.57 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of...

  3. 9 CFR 3.59 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false 3.59 Section 3.59 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of Rabbits Animal Health and...

  4. 9 CFR 3.59 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false 3.59 Section 3.59 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of Rabbits Animal Health and...

  5. 9 CFR 3.57 - Employees.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Employees. 3.57 Section 3.57 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of...

  6. 9 CFR 3.55 - Watering.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Watering. 3.55 Section 3.55 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of...

  7. 9 CFR 3.57 - Employees.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Employees. 3.57 Section 3.57 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of...

  8. 9 CFR 3.55 - Watering.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Watering. 3.55 Section 3.55 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of...

  9. 9 CFR 3.57 - Employees.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Employees. 3.57 Section 3.57 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of...

  10. 9 CFR 3.59 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false 3.59 Section 3.59 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of Rabbits Animal Health and...

  11. 9 CFR 3.59 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false 3.59 Section 3.59 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of Rabbits Animal Health and...

  12. 9 CFR 3.125 - Facilities, general.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Facilities, general. 3.125 Section 3.125 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation...

  13. 9 CFR 3.125 - Facilities, general.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Facilities, general. 3.125 Section 3.125 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation...

  14. 9 CFR 3.125 - Facilities, general.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Facilities, general. 3.125 Section 3.125 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation...

  15. 9 CFR 3.51 - Facilities, indoor.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Facilities, indoor. 3.51 Section 3.51 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment and Transportation of Rabbits Facilities and Operating Standards §...

  16. 9 CFR 3.102 - Facilities, indoor.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Facilities, indoor. 3.102 Section 3.102 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Marine Mammals Facilities and...

  17. 9 CFR 3.26 - Facilities, indoor.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Facilities, indoor. 3.26 Section 3.26 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Guinea Pigs and Hamsters Facilities...

  18. 9 CFR 381.3 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 2 2013-01-01 2013-01-01 false Administration. 381.3 Section 381.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... the event of a public health emergency or to permit experimentation so that new procedures,...

  19. 9 CFR 381.3 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Administration. 381.3 Section 381.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... the event of a public health emergency or to permit experimentation so that new procedures,...

  20. 9 CFR 381.3 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Administration. 381.3 Section 381.3 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE AGENCY... the event of a public health emergency or to permit experimentation so that new procedures,...