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Sample records for 3-month period results

  1. Video Evidence That London Infants Can Resettle Themselves Back to Sleep After Waking in the Night, as well as Sleep for Long Periods, by 3 Months of Age

    PubMed Central

    Hovish, Kimberly; Owen, Charlie

    2015-01-01

    ABSTRACT: Objective: Most infants become settled at night by 3 months of age, whereas infants not settled by 5 months are likely to have long-term sleep-waking problems. We assessed whether normal infant development in the first 3 months involves increasing sleep-period length or the ability to resettle autonomously after waking in the night. Methods: One hundred one infants were assessed at 5 weeks and 3 months of age using nighttime infrared video recordings and parental questionnaires. Results: The clearest development was in sleep length; 45% of infants slept continuously for ≥5 hours at night at 3 months compared with 10% at 5 weeks. In addition, around a quarter of infants woke and resettled themselves back to sleep in the night at each age. Autonomous resettling at 5 weeks predicted prolonged sleeping at 3 months suggesting it may be a developmental precursor. Infants reported by parents to sleep for a period of 5 hours or more included infants who resettled themselves and those with long sleeps. Three-month olds fed solely breast milk were as likely to self-resettle or have long sleep bouts as infants fed formula or mixed breast and formula milk. Conclusions: Infants are capable of resettling themselves back to sleep in the first 3 months of age; both autonomous resettling and prolonged sleeping are involved in “sleeping through the night” at an early age. Findings indicate the need for physiological studies of how arousal, waking, and resettling develop into sustained sleeping and of how environmental factors support these endogenous and behavioral processes. PMID:26035139

  2. Excess Body Mass Index Loss at 3 Months: A Predictive Factor of Long-Term Result after Sleeve Gastrectomy

    PubMed Central

    Philouze, Guillaume; Voitellier, Eglantine; Lacaze, Laurence; Huet, Emmanuel; Gancel, Antoine; Prévost, Gaëtan

    2017-01-01

    Introduction. Laparoscopic Sleeve Gastrectomy (SG) is considered as successful if the percentage of Excess Body Mass Index Loss (% EBMIL) remains constant over 50% with long-term follow-up. The aim of this study was to evaluate whether early % EBMIL was predictive of success after SG. Methods. This retrospective study included patients who had SG with two years of follow-up. Patients had follow-up appointments at 3 (M3), 6, 12, and 24 months (M24). Data as weight and Body Mass Index (BMI) were collected systematically. We estimated the % EBMIL necessary to establish a correlation between M3 and M24 compared to % EBMIL speeds and calculated a limit value of % EBMIL predictive of success. Results. Data at operative time, M3, and M24 were available for 128 patients. Pearson test showed a correlation between % EBMIL at M3 and that at M24 (r = 0.74; p < 0.0001). % EBMIL speed between surgery and M3 (p = 0.0011) was significant but not between M3 and M24. A linear regression analysis proved that % EBMIL over 20.1% at M3 (p < 0.0001) predicted a final % EBMIL over 50%. Conclusions. % EBMIL at M3 after SG is correlated with % EBMIL in the long term. % EBMIL speed was significant in the first 3 months. % EBMIL over 20.1% at M3 leads to the success of SG. PMID:28250984

  3. A randomized controlled trial of brain training with non-action video games in older adults: results of the 3-month follow-up.

    PubMed

    Ballesteros, Soledad; Mayas, Julia; Prieto, Antonio; Toril, Pilar; Pita, Carmen; Laura, Ponce de León; Reales, José M; Waterworth, John A

    2015-01-01

    This randomized controlled study (ClinicalTrials.gov NCT02007616) investigated the maintenance of training effects of 20 1-hr non-action video game training sessions with selected games from a commercial package on several age-declining cognitive functions and subjective wellbeing after a 3-month no-contact period. Two groups of cognitively normal older adults participated in both the post-training (posttest) and the present follow-up study, the experimental group who received training and the control group who attended several meetings with the research team during the study but did not receive training. Groups were similar at baseline on demographics, vocabulary, global cognition, and depression status. Significant improvements in the trained group, and no variation in the control group had been previously found at posttest, in processing speed, attention and visual recognition memory, as well as in two dimensions of subjective wellbeing. In the current study, improvement from baseline to 3 months follow-up was found only in wellbeing (Affection and Assertivity dimensions) in the trained group whereas there was no change in the control group. Previous significant improvements in processing speed, attention and spatial memory become non-significant after the 3-month interval. Training older adults with non-action video games enhanced aspects of cognition just after training but this effect disappeared after a 3-month no-contact follow-up period. Cognitive plasticity can be induced in older adults by training, but to maintain the benefits periodic boosting sessions would be necessary.

  4. A randomized controlled trial of brain training with non-action video games in older adults: results of the 3-month follow-up

    PubMed Central

    Ballesteros, Soledad; Mayas, Julia; Prieto, Antonio; Toril, Pilar; Pita, Carmen; Laura, Ponce de León; Reales, José M.; Waterworth, John A.

    2015-01-01

    This randomized controlled study (ClinicalTrials.gov NCT02007616) investigated the maintenance of training effects of 20 1-hr non-action video game training sessions with selected games from a commercial package on several age-declining cognitive functions and subjective wellbeing after a 3-month no-contact period. Two groups of cognitively normal older adults participated in both the post-training (posttest) and the present follow-up study, the experimental group who received training and the control group who attended several meetings with the research team during the study but did not receive training. Groups were similar at baseline on demographics, vocabulary, global cognition, and depression status. Significant improvements in the trained group, and no variation in the control group had been previously found at posttest, in processing speed, attention and visual recognition memory, as well as in two dimensions of subjective wellbeing. In the current study, improvement from baseline to 3 months follow-up was found only in wellbeing (Affection and Assertivity dimensions) in the trained group whereas there was no change in the control group. Previous significant improvements in processing speed, attention and spatial memory become non-significant after the 3-month interval. Training older adults with non-action video games enhanced aspects of cognition just after training but this effect disappeared after a 3-month no-contact follow-up period. Cognitive plasticity can be induced in older adults by training, but to maintain the benefits periodic boosting sessions would be necessary. PMID:25926790

  5. 3-Month Results from Denmark within the Globally Prospective and Observational Study to Evaluate Insulin Detemir Treatment in Type 1 and Type 2 Diabetes: The PREDICTIVE Study

    PubMed Central

    Hermansen, Kjeld; Lund, Per; Clemmensen, Kurt; Breum, Leif; Kleis Moller, Marianne; Mette Rosenfalck, Anne; Christiansen, Erik; on behalf of the Danish PREDICTIVE study group

    2007-01-01

    PREDICTIVE™ is a large, multi-national, open-label, prospective, observational study to assess the efficacy and safety of insulin detemir in clinical practice. We report 3-month follow-up data from 389 patients with type 1 (n = 312) and type 2 (n = 77) diabetes from Denmark. Insulin detemir improved glycemic control in type 1 patients, with decreases in mean HbA1c (-0.2%, p = 0.0026), fasting glucose (-1.7 mmol/l, p = 0.0033) and within-patient fasting glucose variability (-0.6 mmol/l, p = 0.0472). Non-significant reductions in glycemic parameters were observed in type 2 patients (-0.3% for HbA1c and -2.7 mmol/l for fasting glucose). There was a decrease in mean body weight in both type 1 and type 2 patients (-0.6 kg, p = 0.025 and -1.0 kg, p = 0.0361, respectively). Three patients (0.8%) reported 4 serious adverse drug reactions, including major hypoglycemia. The incidence of major hypoglycemic episodes was reduced from 3.9/patient-years at baseline to 0.4/patient-years at follow-up in type 1 patients (p < 0.0001), and from 1.0 to 0.0/patient-years in type 2 patients (p = 0.1250). In addition, the mean incidence of total and nocturnal hypoglycemic episodes was reduced in both type 1 (-37.4 and -17.7/patient-years, p < 0.0001 for both) and type 2 patients (-17.7 and -7.8/patient-years, p = 0.0012 and p = 0.0020, respectively). The observations from the Danish cohort of the PREDICTIVE study support the overall findings of PREDICTIVE, i.e. insulin detemir improves glycemic control, with a reduced risk of hypoglycemia and no weight gain. PMID:17823693

  6. Scheduling periodic jobs using imprecise results

    NASA Technical Reports Server (NTRS)

    Chung, Jen-Yao; Liu, Jane W. S.; Lin, Kwei-Jay

    1987-01-01

    One approach to avoid timing faults in hard, real-time systems is to make available intermediate, imprecise results produced by real-time processes. When a result of the desired quality cannot be produced in time, an imprecise result of acceptable quality produced before the deadline can be used. The problem of scheduling periodic jobs to meet deadlines on a system that provides the necessary programming language primitives and run-time support for processes to return imprecise results is discussed. Since the scheduler may choose to terminate a task before it is completed, causing it to produce an acceptable but imprecise result, the amount of processor time assigned to any task in a valid schedule can be less than the amount of time required to complete the task. A meaningful formulation of the scheduling problem must take into account the overall quality of the results. Depending on the different types of undesirable effects caused by errors, jobs are classified as type N or type C. For type N jobs, the effects of errors in results produced in different periods are not cumulative. A reasonable performance measure is the average error over all jobs. Three heuristic algorithms that lead to feasible schedules with small average errors are described. For type C jobs, the undesirable effects of errors produced in different periods are cumulative. Schedulability criteria of type C jobs are discussed.

  7. Infant Development: Birth to 3 Months

    MedlinePlus

    ... major infant development milestones from birth to 3 months — and know what to do when something's not ... A lot happens during your baby's first three months. Most babies reach certain milestones at similar ages, ...

  8. Independent Predictors of Recovery of Continence 3 Months After Robot-Assisted Laparoscopic Radical Prostatectomy

    PubMed Central

    Kim, Jung Jun; Ha, Yun-Sok; Kim, Jeong Hyun; Jeon, Seong Soo; Lee, Dong-Hyeon; Kim, Wun-Jae

    2012-01-01

    Abstract Purpose To investigate the factors that predict recovery of continence within 3 months after robot-assisted radical prostatectomy (RARP). Patients and Methods The charts of 452 patients who underwent RARP with a minimum follow-up period of 3 months were collected prospectively and reviewed retrospectively. Urinary continence was determined using the self-administered validated Expanded Prostate Cancer Index Composite questionnaire during the routine follow-up visits. Results The overall continence rate 3 months after RARP was 79.9%. In an univariate logistic regression test, age<70 years, higher preoperative Sexual Health Inventory for Men (SHIM) score, lower clinical T1 stage, lower biopsy and pathologic Gleason score, shorter operative time, lower estimated blood loss, smaller prostate volume (<40 cc) were associated with recovery of urinary continence within 3 months after RARP (P<0.05). In multivariate logistic regression analysis, younger age, higher SHIM score, lower clinical T1 stage, lower body mass index (BMI), and smaller prostate volume were independent factors that predicted return of continence within 3 months after RARP (P<0.05). Conclusions Younger age (<70 years), higher preoperative SHIM score, clinical T1 stage, lower BMI, and smaller prostate volume (<40 cc) independently predicted recovery of continence within 3 months after RARP. PMID:22651546

  9. Scheduling periodic jobs that allow imprecise results

    NASA Technical Reports Server (NTRS)

    Chung, Jen-Yao; Liu, Jane W. S.; Lin, Kwei-Jay

    1990-01-01

    The problem of scheduling periodic jobs in hard real-time systems that support imprecise computations is discussed. Two workload models of imprecise computations are presented. These models differ from traditional models in that a task may be terminated any time after it has produced an acceptable result. Each task is logically decomposed into a mandatory part followed by an optional part. In a feasible schedule, the mandatory part of every task is completed before the deadline of the task. The optional part refines the result produced by the mandatory part to reduce the error in the result. Applications are classified as type N and type C, according to undesirable effects of errors. The two workload models characterize the two types of applications. The optional parts of the tasks in an N job need not ever be completed. The resulting quality of each type-N job is measured in terms of the average error in the results over several consecutive periods. A class of preemptive, priority-driven algorithms that leads to feasible schedules with small average error is described and evaluated.

  10. 9 CFR 206.3 - Monthly report.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE SWINE CONTRACT LIBRARY § 206.3 Monthly report. (a) Do I need... swine processing plant that it operates or at which it has swine slaughtered that has the slaughtering... report, each packer must provide the following information: (1) Number of swine to be delivered...

  11. Prospective, longitudinal assessment of quality of life in children from diagnosis to 3 months off treatment for standard risk acute lymphoblastic leukemia: Results of Children's Oncology Group study AALL0331.

    PubMed

    Mitchell, Hannah-Rose; Lu, Xiaomin; Myers, Regina M; Sung, Lillian; Balsamo, Lyn M; Carroll, William L; Raetz, Elizabeth; Loh, Mignon L; Mattano, Leonard A; Winick, Naomi J; Devidas, Meenakshi; Hunger, Stephen P; Maloney, Kelly; Kadan-Lottick, Nina S

    2016-01-15

    Standard risk acute lymphoblastic leukemia (SR-ALL) has high cure rates, but requires 2-3 years of therapy. We aimed to (i) prospectively evaluate health-related quality of life (HRQOL) during and after SR-ALL therapy, and (ii) identify associated predictors. Parents of 160 SR-ALL patients enrolled on Children's Oncology Group (COG) therapeutic trial AALL0331 at 31 sites completed the Pediatric Quality of Life Inventory (PedsQL) 4.0 Generic Core Scales (physical, emotional and social functioning) and Family Assessment Device-General Functioning (FAD-GF) at 1, 6 and 12 months after diagnosis, and 3 months post-therapy. Mean PedsQL scores in physical, emotional and social functioning were impaired 1 month after diagnosis but steadily improved. Three months post-therapy, impaired physical and social functioning was observed in 27.8 and 25.8% of patients, respectively. In repeated-measures analysis, problematic family functioning predicted emotional (OR = 1.85, 95% CI 1.03-3.34) and social (OR = 1.99, 95% CI 1.21-3.27) impairment. Larger household size was associated with social impairment (OR = 1.21, 95% CI 1.02-1.45). Adverse neurological event(s) during therapy predicted post-therapy physical (OR = 5.17, 95% CI 1.61-16.63) and social (OR = 8.17, 95% CI 1.19-56.16) impairment. HRQOL 1 month after diagnosis was not predictive of HRQOL 3 months after therapy completion. In conclusion, children with SR-ALL experience considerable impairment in HRQOL at the end of induction, but rapidly improve. However, many still experience physical and social impairment 3 months post-therapy, suggesting a role for continued family and physical functioning support. Longer follow-up is needed to determine if post-therapy deficits change over time.

  12. Mother's stress, mood and emotional involvement with the infant: 3 months before and 3 months after childbirth.

    PubMed

    Figueiredo, Barbara; Costa, Raquel

    2009-06-01

    Adverse effects of maternal anxiety and depression are well documented, namely on the foetus/child behaviour and development, but not as much attention has been given to the mother's emotional involvement with the offspring. To study mother's prenatal and postpartum stress, mood and emotional involvement with the infant, the State-Trait Anxiety Inventory, the Edinburgh Postnatal Depression Scale and the Mother-to-Infant Bonding Scale were filled in and cortisol levels were measured, 3 months before and 3 months after childbirth, in a sample of 91 Portuguese women. From pregnancy to the postpartum period, mother's cortisol levels, anxiety and emotional involvement toward the child decrease. No significant change was observed regarding mother's depression. Mother's depression predicted a worse emotional involvement before childbirth, while mother's anxiety predicted a worse emotional involvement with the infant after childbirth. Additionally, pregnant women with a worse emotional involvement with the offspring are at risk of poorer emotional involvement with the infant and higher anxiety and depression at 3 months postpartum. It should be given more attention to mother's poor emotional involvement with the offspring during pregnancy, as it interferes with her emotional involvement with the infant and her psychological adjustment 3 months after childbirth.

  13. Fractured condyle in a 3-month-old infant.

    PubMed

    Cambell, R L; Moore, R F

    1975-07-01

    A 3-month-old infant sustained trauma to the mandibular symphysis resulting in radiographic evidence of a fracture of the right condylar head. This presented the diffculty of performing a clinical examination and total reliance on history of a trauma and subsequent swelling. Multiple radiographs of the condyles were used to establish the diagnosis and rule out a film artifact. No definitive treatment was required other than muscle exercises and parental instruction as to potential problems.

  14. Development of a novel 3-month drug releasing risperidone microspheres

    PubMed Central

    Yerragunta, Bhanusree; Jogala, Satheesh; Chinnala, Krishna Mohan; Aukunuru, Jithan

    2015-01-01

    Objective: The purpose of this study was to develop an ideal microsphere formulation of risperidone that would prolong the drug release for 3 months in vivo and avoid the need for co-administration of oral tablets. Materials and Methods: Polycaprolactones (PCL) were used as polymers to prepare microspheres. The research included screening and optimizing of suitable commercial polymers of variable molecular weights: PCL-14000, PCL-45000, PCL-80000 or the blends of these polymers to prepare microspheres with zero-order drug-releasing properties without the lag phase. In the present study, the sustained release risperidone microspheres were prepared by o/w emulsion solvent evaporation technique and the yield was determined. Microspheres were evaluated for their drug content and in vitro drug release. Microspheres prepared using a blend of PCL-45000 and PCL-80000 at a ratio of 1:1 resulted in the release of the drug in a time frame of 90 days, demonstrated zero-order drug release without lag time and burst release. This formulation was considered optimized formulation. Optimized formulation was characterized for solid state of the drug using differential scanning calorimetry, surface morphology using scanning electron microscopy and in vivo drug release in rats. Results: The surface of the optimized formulation was smooth, and the drug changed its physical form in the presence of blends of polymers and upon fabrication of microspheres. The optimized formulation also released the drug in vivo for a period of 90 days. Conclusions: From our study, it was concluded that these optimized microspheres showed great potential for a better depot preparation than the marketed Risperdal Consta™ and, therefore, could further improve patient compliance. PMID:25709335

  15. Feeding Your 1- to 3-Month-Old

    MedlinePlus

    ... 2-Year-Old Feeding Your 1- to 3-Month-Old KidsHealth > For Parents > Feeding Your 1- to 3-Month-Old A A A en español Alimentar a ... meses de edad During your baby's first 3 months, breast milk or formula will provide all the ...

  16. Feeding Your 1- to 3-Month-Old

    MedlinePlus

    ... 2-Year-Old Feeding Your 1- to 3-Month-Old KidsHealth > For Parents > Feeding Your 1- to 3-Month-Old Print A A A en español Alimentar ... meses de edad During your baby's first 3 months, breast milk or formula will provide all the ...

  17. Cardiometabolic Health in Submariners Returning from a 3-Month Patrol

    PubMed Central

    Gasier, Heath G.; Young, Colin R.; Gaffney-Stomberg, Erin; McAdams, Douglas C.; Lutz, Laura J.; McClung, James P.

    2016-01-01

    Confined space, limited exercise equipment, rotating shift work and reduced sleep may affect cardiometabolic health in submariners. To test this hypothesis, 53 male U.S. Submariners (20–39 years) were studied before and after a 3-month routine submarine patrol. Measures included anthropometrics, dietary and physical activity, biomarkers of cardiometabolic health, energy and appetite regulation, and inflammation. Before deployment, 62% of submariners had a body fat % (BF%) ≥ 25% (obesity), and of this group, 30% met the criteria for metabolic syndrome. In obese volunteers, insulin, the homeostatic model assessment of insulin resistance (HOMA-IR), leptin, the leptin/adiponectin ratio, and pro-inflammatory chemokines growth-related oncogene and macrophage-derived chemokine were significantly higher compared to non-obese submariners. Following the patrol, a significant mean reduction in body mass (5%) and fat-mass (11%) occurred in the obese group as a result of reduced energy intake (~2000 kJ) during the patrol; and, independent of group, modest improvements in serum lipids and a mean reduction in interferon γ-induced protein 10 and monocyte chemotactic protein 1 were observed. Since 43% of the submariners remained obese, and 18% continued to meet the criteria for metabolic syndrome following the patrol, the magnitude of weight loss was insufficient to completely abolish metabolic dysfunction. Submergence up to 3-months, however, does not appear to be the cause of obesity, which is similar to that of the general population. PMID:26867201

  18. Periodic nonlinearity resulting from ghost reflections in heterodyne interferometry

    NASA Astrophysics Data System (ADS)

    Wu, Chien-ming

    2003-01-01

    Periodic nonlinearity is a systematic error limiting the accuracy of displacement measurements at the nanometer level. It results from many causes such as frequency mixing, polarization mixing, polarization-frequency mixing, and ghost reflections. The purpose of this paper is to study the periodic nonlinearity resulting from ghost reflections, which has not been investigated before. A generalized scheme of interferometer, which is free of frequency and polarization mixings, is used in the study. This ensures that the residual periodic nonlinearity is from the ghost reflections only. In this paper, a general form of periodic nonlinearity and a model including two kinds of ghost reflections, one with the same frequency and the other with two frequencies, are presented. The model is verified by experimental results.

  19. Medical Care and Your 1- to 3-Month-Old

    MedlinePlus

    ... Old Medical Care and Your 1- to 3-Month-Old KidsHealth > For Parents > Medical Care and Your 1- to 3-Month-Old A A A What's in this article? ... When to Call the Doctor During these early months, you might have many questions about your baby's ...

  20. Learning, Play, and Your 1- to 3-Month-Old

    MedlinePlus

    ... Old Learning, Play, and Your 1- to 3-Month-Old KidsHealth > For Parents > Learning, Play, and Your 1- to 3-Month-Old A A A What's in this article? ... start responding even more to you during these months — and will even give you a smile! Babies ...

  1. Learning, Play, and Your 1- to 3-Month-Old

    MedlinePlus

    ... Old Learning, Play, and Your 1- to 3-Month-Old KidsHealth > For Parents > Learning, Play, and Your 1- to 3-Month-Old Print A A A What's in this ... start responding even more to you during these months — and will even give you a smile! Babies ...

  2. Medical Care and Your 1- to 3-Month-Old

    MedlinePlus

    ... Old Medical Care and Your 1- to 3-Month-Old KidsHealth > For Parents > Medical Care and Your 1- to 3-Month-Old Print A A A What's in this ... When to Call the Doctor During these early months, you might have many questions about your baby's ...

  3. Coping Card Usage can Further Reduce Suicide Reattempt in Suicide Attempter Case Management Within 3-Month Intervention.

    PubMed

    Wang, Ying-Chuan; Hsieh, Ling-Yu; Wang, Ming-Yu; Chou, Cheng-Hsiang; Huang, Min-Wei; Ko, Huei-Chen

    2016-02-01

    This randomized controlled trial was designed to evaluate the effectiveness of using crisis coping cards (n = 32) in the case management of suicide prevention compared with case management without the use of coping cards (n = 32) over a 3-month intervention period. The generalized estimating equation was used to examine the interaction effect between treatments and time on suicide risk, depression, anxiety, and hopelessness. Results indicated that subsequent suicidal behaviors, severity of suicide risk, depression, anxiety, and hopelessness were reduced more in the coping card intervention group compared to the case management only group. Moreover, for the survival curves of time to suicide reattempt, the coping card group showed a significantly longer time to reattempt than the case management only group at 2-month and 3-month intervention periods.

  4. Senses and Your 1- to 3-Month-Old

    MedlinePlus

    ... the Classroom What Other Parents Are Reading Your Child's Development (Birth to 3 Years) Feeding Your 1- to ... and Your 1- to 3-Month-Old Your Child’s Development: 1 Month Contact Us Print Resources Send to ...

  5. Scheduling real-time, periodic jobs using imprecise results

    NASA Technical Reports Server (NTRS)

    Liu, Jane W. S.; Lin, Kwei-Jay; Natarajan, Swaminathan

    1987-01-01

    A process is called a monotone process if the accuracy of its intermediate results is non-decreasing as more time is spent to obtain the result. The result produced by a monotone process upon its normal termination is the desired result; the error in this result is zero. External events such as timeouts or crashes may cause the process to terminate prematurely. If the intermediate result produced by the process upon its premature termination is saved and made available, the application may still find the result unusable and, hence, acceptable; such a result is said to be an imprecise one. The error in an imprecise result is nonzero. The problem of scheduling periodic jobs to meet deadlines on a system that provides the necessary programming language primitives and run-time support for processes to return imprecise results is discussed. This problem differs from the traditional scheduling problems since the scheduler may choose to terminate a task before it is completed, causing it to produce an acceptable but imprecise result. Consequently, the amounts of processor time assigned to tasks in a valid schedule can be less than the amounts of time required to complete the tasks. A meaningful formulation of this problem taking into account the quality of the overall result is discussed. Three algorithms for scheduling jobs for which the effects of errors in results produced in different periods are not cumulative are described, and their relative merits are evaluated.

  6. Paliperidone Palmitate Intramuscular 3-Monthly Formulation: A Review in Schizophrenia.

    PubMed

    Lamb, Yvette N; Keating, Gillian M

    2016-10-01

    A 3-monthly formulation of intramuscular paliperidone palmitate (3-monthly paliperidone palmitate) has recently been approved for the maintenance treatment of schizophrenia in adult patients in the EU (Trevicta(®)), following earlier approval in the USA (Invega Trinza(®)). This narrative review discusses the clinical use of 3-monthly paliperidone palmitate in the maintenance treatment of schizophrenia in adult patients and summarizes its pharmacological properties. The efficacy of the 3-monthly paliperidone palmitate formulation as a maintenance treatment for schizophrenia has been demonstrated in well designed, phase III trials. Three-monthly paliperidone palmitate was more effective than placebo in delaying time to relapse and reducing relapse rates, and was noninferior to 1-monthly paliperidone palmitate in the proportion of patients that remained relapse-free. The 3-monthly formulation was also more effective than placebo in controlling the symptoms of schizophrenia, whilst not differing significantly from the 1-monthly formulation in terms of symptomatic control. Three-monthly paliperidone palmitate was generally well tolerated in clinical trials, with a tolerability profile consistent with that of the 1-monthly formulation. In conclusion, 3-monthly paliperidone palmitate is a useful treatment option for adult patients with schizophrenia who are adequately treated with the 1-monthly formulation, particularly for those who would prefer, or may benefit from, longer dosing intervals.

  7. Renal nephroblastoma in a 3-month-old golden retriever.

    PubMed

    Montinaro, Vincenzo; Boston, Sarah E; Stevens, Brian

    2013-07-01

    Nephrectomy was performed in a 3-month-old intact female golden retriever dog for a renal nephroblastoma. The dog has remained disease-free for 19 months with nephrectomy alone. The adoption of human Wilms' tumor grading criteria may be useful in determining clinical stage, adjuvant treatment options, and prognosis in this rare disease.

  8. Emotional and Social Development: Birth to 3 Months

    MedlinePlus

    ... Share Emotional and Social Development: Birth to 3 Months Page Content Article Body By the second month, your baby will spend much of each day ... he can smile, too. Even during his first month, he’ll experiment with primitive grins and grimaces. ...

  9. Renal nephroblastoma in a 3-month-old golden retriever

    PubMed Central

    Montinaro, Vincenzo; Boston, Sarah E.; Stevens, Brian

    2013-01-01

    Nephrectomy was performed in a 3-month-old intact female golden retriever dog for a renal nephroblastoma. The dog has remained disease-free for 19 months with nephrectomy alone. The adoption of human Wilms’ tumor grading criteria may be useful in determining clinical stage, adjuvant treatment options, and prognosis in this rare disease. PMID:24155463

  10. Effectiveness of MR Angiography for the Primary Diagnosis of Acute Pulmonary Embolism: Clinical Outcomes at 3 Months and 1 Year

    PubMed Central

    Schiebler, Mark L.; Nagle, Scott K.; François, Christopher J.; Repplinger, Michael D.; Hamedani, Azita G.; Vigen, Karl K.; Yarlagadda, Rajkumar; Grist, Thomas M.; Reeder, Scott B.

    2014-01-01

    Purpose To determine the effectiveness of MR angiography for pulmonary embolism (MRA-PE) in symptomatic patients. Materials and Methods We retrospectively reviewed all patients whom were evaluated for possible pulmonary embolism (PE) using MRA-PE. A 3-month and 1-year from MRA-PE electronic medical record (EMR) review was performed. Evidence for venous thromboembolism (VTE) (or death from PE) within the year of follow-up was the outcome surrogate for this study. Results There were 190 MRA-PE exams performed with 97.4% (185/190) of diagnostic quality. There were 148 patients (120 F: 28 M) that had both a diagnostic MRA-PE exam and 1 complete year of EMR follow-up. There were 167 patients (137 F: 30 M) with 3 months or greater follow-up. We found 83% (139/167) and 81% (120/148) MRA-PE exams negative for PE at 3 months and 1 year, respectively. Positive exams for PE were seen in 14% (23/167). During the 1-year follow-up period, five patients (false negative) were diagnosed with DVT (5/148 = 3.4 %), and one of these patients also experienced a non–life-threatening PE. The negative predictive value (NPV) for MRA-PE was 97% (92–99; 95% CI) at 3 months and 96% (90–98; 95% CI) with 1 year of follow-up. Conclusion The NPV of MRA-PE, when used for the primary diagnosis of pulmonary embolism in symptomatic patients, were found to be similar to the published values for CTA-PE. In addition, the technical success rate and safety of MRA-PE were excellent. PMID:23553735

  11. Periodization

    PubMed Central

    Lorenz, Daniel S.; Reiman, Michael P.; Walker, John C.

    2010-01-01

    Background: Clinicians are constantly faced with the challenge of designing training programs for injured and noninjured athletes that maximize healing and optimize performance. Periodization is a concept of systematic progression—that is, resistance training programs that follow predictable patterns of change in training variables. The strength training literature is abundant with studies comparing periodization schemes on uninjured, trained, and untrained athletes. The rehabilitation literature, however, is scarce with information about how to optimally design resistance training programs based on periodization principles for injured athletes. The purpose of this review is to discuss relevant training variables and methods of periodization, as well as periodization program outcomes. A secondary purpose is to provide an anecdotal framework regarding implementation of periodization principles into rehabilitation programs. Evidence Acquisition: A Medline search from 1979 to 2009 was implemented with the keywords periodization, strength training, rehabilitation, endurance, power, hypertrophy, and resistance training with the Boolean term AND in all possible combinations in the English language. Each author also undertook independent hand searching of article references used in this review. Results: Based on the studies researched, periodized strength training regimens demonstrate improved outcomes as compared to nonperiodized programs. Conclusions: Despite the evidence in the strength training literature supporting periodization programs, there is a considerable lack of data in the rehabilitation literature about program design and successful implementation of periodization into rehabilitation programs. PMID:23015982

  12. Patient-reported outcomes 3 months after spine surgery: is it an accurate predictor of 12-month outcome in real-world registry platforms?

    PubMed

    Parker, Scott L; Asher, Anthony L; Godil, Saniya S; Devin, Clinton J; McGirt, Matthew J

    2015-12-01

    OBJECT The health care landscape is rapidly shifting to incentivize quality of care rather than quantity of care. Quality and outcomes registry platforms lie at the center of all emerging evidence-driven reform models and will be used to inform decision makers in health care delivery. Obtaining real-world registry outcomes data from patients 12 months after spine surgery remains a challenge. The authors set out to determine whether 3-month patient-reported outcomes accurately predict 12-month outcomes and, hence, whether 3-month measurement systems suffice to identify effective versus noneffective spine care. METHODS All patients undergoing lumbar spine surgery for degenerative disease at a single medical institution over a 2-year period were enrolled in a prospective longitudinal registry. Patient-reported outcome instruments (numeric rating scale [NRS], Oswestry Disability Index [ODI], 12-Item Short Form Health Survey [SF-12], EQ-5D, and the Zung Self-Rating Depression Scale) were recorded prospectively at baseline and at 3 months and 12 months after surgery. Linear regression was performed to determine the independent association of 3- and 12-month outcome. Receiver operating characteristic (ROC) curve analysis was performed to determine whether improvement in general health state (EQ-5D) and disability (ODI) at 3 months accurately predicted improvement and achievement of minimum clinical important difference (MCID) at 12 months. RESULTS A total of 593 patients undergoing elective lumbar surgery were included in the study. There was a significant correlation between 3-month and 12-month EQ-5D (r = 0.71; p < 0.0001) and ODI (r = 0.70; p < 0.0001); however, the authors observed a sizable discrepancy in achievement of a clinically significant improvement (MCID) threshold at 3 versus 12 months on an individual patient level. For postoperative disability (ODI), 11.5% of patients who achieved an MCID threshold at 3 months dropped below this threshold at 12 months; 10

  13. Rigorous KAM results around arbitrary periodic orbits for Hamiltonian systems

    NASA Astrophysics Data System (ADS)

    Kapela, Tomasz; Simó, Carles

    2017-03-01

    We set up a methodology for computer assisted proofs of the existence and the KAM stability of an arbitrary periodic orbit for Hamiltonian systems. We give two examples of application for systems with two and three degrees of freedom. The first example verifies the existence of tiny elliptic islands inside large chaotic domains for a quartic potential. In the 3-body problem we prove the KAM stability of the well-known figure eight orbit and two selected orbits of the so called family of rotating eights. Some additional theoretical and numerical information is also given for the dynamics of both examples.

  14. [Tuberculosis in infants less than 3 months of age].

    PubMed

    Del Rosal Rabes, Teresa; Baquero-Artigao, Fernando; Méndez-Echevarría, Ana María; Mellado Peña, María José

    2015-04-29

    A review was conducted on infants less than 3 months of age diagnosed with tuberculosis between 1978 and 2014. Eight patients were diagnosed (1.4% of paediatric tuberculosis cases): 3 confirmed congenital tuberculosis, 3 suspected (endometrial biopsy was not performed), and 2 postnatal tuberculosis. Tuberculin skin test was negative in two patients. Diagnostic performance of culture (7/7, 100%) and PCR (3/3, 100%) of gastric aspirates was higher than that of acid-fast bacilli smears (5/8, 62%) and IGRA test (1/3, 33%). Three patients developed miliary disease, and one died. In conclusion, tuberculosis in this age group is rare, severe, and difficult to diagnose. In cases lacking known postnatal contacts, maternal genital tuberculosis should be ruled out by endometrial biopsy.

  15. Identifying predictors of resilience at inpatient and 3-month post-spinal cord injury

    PubMed Central

    Warren, Ann Marie; Reynolds, Megan; Agtarap, Stephanie; Hamilton, Rita; Trost, Zina; Monden, Kimberly

    2016-01-01

    Objectives To identify (1) changes in psychosocial factors, (2) relationships between psychosocial factors, and (3) significant predictors of resilience in adults with spinal cord injury (SCI) during inpatient rehabilitation and at 3-month post-discharge. Design Cross sectional with convenience sample based on inclusion/exclusion criteria. Setting Inpatient rehabilitation hospital and community-based follow-up. Participants Individuals with a SCI. Interventions Not applicable. Outcome measures Demographic, resilience, self-efficacy for managing a chronic health issue, depression, social roles/activity limitations, and pain. Results The final sample consisted of 44 respondents (16 women and 28 men). Results of repeated measure analyses of variance indicated no significant changes in variables between inpatient and 3-month follow-up. Bivariate correlations revealed associations between resilience and self-efficacy at inpatient (r = 0.54, P < 0.001), and resilience and depression (r = −0.69, P < 0.001) and self-efficacy (r = 0.67, P < 0.001) at 3-month follow-up. Hierarchical regression analyses a significant model predicting resilience at inpatient stay (R = 0.61; adjusted R2 = 0.24, P = 0.023), and at 3-month follow-up (R = 0.83; adjusted R2 = 0.49, P = 0.022). Self-efficacy was the strongest predictor at inpatient stay (β = 0.46, P  =  0.006) and depression was strongest at 3-month follow-up (β = −0.80, P = 0.007). Conclusion Results suggest that although resilience appears to be stable from inpatient to 3-month follow-up, different factors are stronger predictors of resilience across time. Based on current results, an assessment of self-efficacy during inpatient rehabilitation and an identification of depression at 3-month follow-up may be important factors to help identify those at risk of health issues overtime. PMID:25297474

  16. Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy

    PubMed Central

    Koyama, Keitaro; Kurokawa, Mineo; Ohtomo, Kuni

    2014-01-01

    Objective. To elucidate the time course of tumor metabolism during the first 3 months after 90Y-ibritumomab tiuxetan radioimmunotherapy (RIT) in patients with refractory malignant lymphoma. Materials and Methods. Seven patients with recurrent follicular lymphoma underwent FDG-PET imaging before and after 1-, 4-, and 12-week RIT with 90Y-ibritumomab tiuxetan. Tumor metabolic activity on FDG-PET scans was assessed as the maximum standard uptake value (SUVmax). Results. Decrease in metabolism was detected 1 week after RIT. In the most decreased lesion, SUVmax decreased to 20% of the baseline value during the first week. Most lesions continued to decrease for up to 4 weeks. Some lesions showed increased metabolism from 4 to 12 weeks, while the level of FDG accumulations at 12 weeks was still lower than the baseline. Conclusions. Tumor response to RIT could be observed as early as 1 week after the administration of RIT. After tumor activity decreases, the metabolism may increase at least between 4 and 12 weeks. It suggests that the metabolic changes should be carefully evaluated during this period. PMID:25050390

  17. Pivotal Response Treatment Parent Training for Autism: Findings from a 3-Month Follow-Up Evaluation.

    PubMed

    Gengoux, Grace W; Berquist, Kari L; Salzman, Emma; Schapp, Salena; Phillips, Jennifer M; Frazier, Thomas W; Minjarez, Mendy B; Hardan, Antonio Y

    2015-09-01

    This study's objective was to assess maintenance of treatment effects 3 months after completion of a 12-week Pivotal Response Treatment (PRT) parent education group. Families who completed the active treatment (N = 23) were followed for an additional 12 weeks to measure changes in language and cognitive skills. Results indicated a significant improvement in frequency of functional utterances, with maintenance at 3-month follow-up [F(2, 21): 5.9, p = .009]. Children also made significant gains on the Vineland Communication Domain Standard Score [F(2, 12):11.74, p = .001] and the Mullen Scales of Early Learning Composite score [F(1, 20) = 5.43, p = .03]. These results suggest that a brief PRT parent group intervention can lead to improvements in language and cognitive functioning that are maintained 12 weeks post treatment.

  18. In Hospital and 3-Month Mortality and Functional Recovery Rate in Patients Treated for Hip Fracture by a Multidisciplinary Team

    PubMed Central

    Rostagno, Carlo; Buzzi, Roberto; Campanacci, Domenico; Boccacini, Alberto; Cartei, Alessandro; Virgili, Gianni; Belardinelli, Andrea; Matarrese, Daniela; Ungar, Andrea; Rafanelli, Martina; Gusinu, Roberto; Marchionni, Niccolò

    2016-01-01

    Objectives Medical comorbidities affect outcome in elderly patients with hip fracture. This study was designed to preliminarily evaluate the usefulness of a hip-fracture unit led by an internal medicine specialist. Methods In-hospital and 3-month outcomes in patients with hip fracture were prospectively evaluated in 121 consecutive patients assessed before and followed after surgery by a multidisciplinary team led by internal medicine specialist; 337 consecutive patients were recalled from ICD-9 discharge records and considered for comparison regarding in-hospital mortality. Results In the intervention period, patients treated within 48 hours were 54% vs. 26% in the historical cohort (P<0.0001). In-hospital mortality remained stable at about 2.3 per 1000 person-days. At 3 months, 10.3% of discharged patients had died, though less than 8% of patients developed postoperative complications (mainly pneumonia and respiratory failure). The presence of more than 2 major comorbidities and the loss of 3 or more BADL were independent predictors of death. 50/105 patients recovered previous functional capacity, but no independent predictor of functional recovery could be identified. Mean length of hospital stay significantly decreased in comparison to the historical cohort (13.6± 4.7 vs 17 ± 5 days, p = 0.0001). Combined end-point of mortality and length of hospitalization < 12 days was significantly lower in study period (27 vs 34%, p <0.0132). Conclusions Identification and stabilization of concomitant clinical problems by internal medicine specialists may safely decrease time to surgery in frail subjects with hip fracture. Moreover, integrated perioperative clinical management may shorten hospital stay with no apparent increase in in-hospital mortality and ultimately improve the outcome. These results are to be confirmed by a larger study presently ongoing at our institution. PMID:27389193

  19. The Relationship between Gentle Tactile Stimulation on the Fetus and Its Temperament 3 Months after Birth

    PubMed Central

    Wang, Zhe-Wei; Hua, Jing; Xu, Yu-Hong

    2015-01-01

    Objective. The aim of this study was to evaluate the effect of gentle tactile stimulation on the fetus in its temperament 3 months after birth. Method. A total of 302 mother-3-month-infant dyads enrolled the retrospective cohort study. 76 mothers had regular gentle tactile stimulation on the fetus in their pregnancy; 62 mothers had irregular tactile stimulation on the fetus, and the rest of 164 mothers who had no tactile stimulation served as nonexposure group. Temperament was assessed using the EITS (a nine-dimensional scale of temperament). Results. Significant difference in temperament type was found among infants in 3 groups at 3 months of age. In the regular practice group, the babies with easy type temperament accounted for 73.7%, which was higher than that in irregular practice group (53.2%, P = 0.012) and that in the control group (42.1%, P < 0.001). Compared to infants in no practice group, the infants who had received regular gentle tactile stimulation before birth were lower in negative mood (P = 0.047) while higher in adaptability (P < 0.001), approach (P = 0.001), and persistence (P = 0.001), respectively. Conclusion. Regular gentle tactile stimulation on fetus may promote the formation of easy type infant temperament. PMID:26180374

  20. Painful Memories: Reliability of Pain Intensity Recall at 3 Months in Senior Patients

    PubMed Central

    Lee, Jacques S.; Griffith, Lauren E.; Paquet, Jean; Chauny, Jean-Marc

    2017-01-01

    Background. Validity of pain recall is questioned in research. Objective. To evaluate the reliability of pain intensity recall for seniors in an emergency department (ED). Methods. This study was part of a prospective multicenter project for seniors (≥65 years old) treated in an ED for minor traumatic injury. Pain intensity (0–10 numerical rating scale) was evaluated at the initial ED visit, at one week (baseline), and 3 months. At three months, patients were asked to recall the pain intensity they had at baseline. Results. 482 patients were interviewed (mean age 76.6 years, SD ± 7.3) and 72.8% were female. Intraclass correlation coefficient between pain at baseline and its recall was 0.24 (95% CI: 0.14–0.33). Senior patients tended to overestimate their pain intensity by a mean of 1.2 (95% CI: 0.9–1.5) units. A stepwise multiple regression analysis showed that the variance of baseline pain recall at 3 months was explained by pain at ED visit (11%), pain at 3 months (7%), and pain at baseline (2%). Conclusion. The accuracy of pain intensity recall after three months is poor in seniors and seems to be influenced by the pain experienced at the time of injury. PMID:28260963

  1. Comparison of CAIRS and STATUS Information Storage and Retrieval Software over a 3-Month Period.

    ERIC Educational Resources Information Center

    Hoey, P. O'N.

    1982-01-01

    The Ministry of Agriculture, Fisheries and Food conducted an operational evaluation of the software packages CAIRS and STATUS, which were used to build databases and databanks. Setting up the trial, types of data involved (chemical products used as pesticides), searching and presentation of data, and the final choice are covered. (EJS)

  2. Septic Arthritis in Infants Younger Than 3 Months: A Retrospective Review.

    PubMed

    Bono, Kenneth T; Samora, Julie Balch; Klingele, Kevin E

    2015-09-01

    Septic arthritis in infants is rare and can be difficult to diagnose. This study reviewed a series of patients younger than 3 months to identify factors that may assist in early diagnosis and treatment. A query of records at a large Midwestern pediatric hospital (1994-2010) was performed to identify all patients younger than 3 months at the time of diagnosis. Analysis included birth history, joint involvement, physical examination findings, laboratory results, imaging results, method of treatment, and outcome. In 14 cases (11 boys, 3 girls; mean age at diagnosis, 42.2 days), complete records were available for review. Involved joints included the knee, hip, and shoulder. The most common findings on physical examination were decreased range of motion (100%), tenderness (100%), and swelling (71.4%). Mean temperature was 38.5°C. Mean white blood cell count was 18.5 K/µL, mean erythrocyte sedimentation rate was 48.9 mm/h, and mean C-reactive protein level was 6.1 mg/dL. More than half (57.1%) of joint aspirates grew positive cultures, and 41.7% of blood cultures had positive results. Causative organisms were group B streptococcus, methicillin-sensitive Staphylococcus aureus, Haemophilus influenzae, Streptococcus pneumoniae, Salmonella enterica, and Candida albicans. The most common physical examination findings in infants younger than 3 months with septic arthritis include tenderness, decreased range of motion, and swelling. White blood cell count, C-reactive protein level, and erythrocyte sedimentation rate are likely to be elevated, but these findings should be used in combination with findings on physical examination and radiographic studies to aid in diagnosis.

  3. Emergence of Functional Flexibility in Infant Vocalizations of the First 3 Months

    PubMed Central

    Jhang, Yuna; Oller, D. Kimbrough

    2017-01-01

    Functional flexibility, as manifest in the use of any word or sentence to express different affective valences on different occasions, is required in linguistic communication and can be said to be an infrastructural property of language. Early infant vocalizations (protophones), believed to be precursors to speech, occur in the first month and are functionally different from non-speech-like signals (e.g., cries and laughs). Oller et al. (2013) showed that infants by 3 months used three different protophone types with a full range of affect as manifest in facial expression, from positive to neutral to negative. These differences in affect were also shown to correspond to different illocutionary functions, unlike fixed signals, or vegetative sounds, which showed functional rigidity. The present study investigated whether infants show functional flexibility in protophones even earlier than the ages studied by Oller et al. (2013). Data were obtained from 6 infants across the first 3 months. Results showed that as early as the first month, infant protophones were already accompanied by variable facial affect valences and continued to be affectively flexible at the later ages. The present study thus documents the very early emergence of an infrastructural property of human communication. PMID:28392770

  4. Parental Relationship with Twins from Pregnancy to 3 Months: The Relation Among Parenting Stress, Infant Temperament, and Well-Being.

    PubMed

    Prino, Laura E; Rollè, Luca; Sechi, Cristina; Patteri, Luciana; Ambrosoli, Anna; Caldarera, Angela M; Gerino, Eva; Brustia, Piera

    2016-01-01

    Objective: The transition to parenthood, from pregnancy to postpartum period, is a critical process, particularly for couples expecting twins. There is very little literature regarding the links between anxiety, depression, dyadic adjustment, parental stress, and infant temperament spanning from pregnancy to postpartum. This study has two aims: first, to examine whether mothers' and fathers' anxiety, depression, and dyadic adjustment, assessed at the sixth month of pregnancy and 3 months postpartum, are associated with infants' negative affectivity (NA) and parenting stress; second, to examine whether there is any difference between fathers' and mothers' levels of parenting stress and perception of the twins' temperament, as well as to evaluate, separately for mothers and fathers, whether the levels of parenting stress and perception of child temperament differ for each twin. Method: The study participants were 58 parents (29 couples) and their healthy 58 twin babies (51.7% boys, 48.3% girls). Mothers' ages ranged from 30 to 44 years, (MAge = 36.3 years, SD = 3.2 years), and fathers' ages ranged from 32 to 52 years, (MAge = 38.2 years, SD = 4.4 years). The parents, during the pregnancy period and 3 months after delivery, filled out the Edinburgh Postnatal Depression Scale, the State-Trait Anxiety Inventory, and the Dyadic Adjustment Scale. Three months after delivery they also filled out the Parenting Stress Index-Short Form and the Infant Behavior Questionnaire Revised. Results: The analyses showed a significant correlation between parental anxiety/depression symptoms and infants' NA and parenting stress (in both mothers and fathers). Moreover, compared to fathers, mothers reported higher scores on specific dimensions of the infants' NA, [t(28) = -2.62 and p < 0.05; t(28) = 2.09 and p < 0.05], and parenting stress, [t(28) = 2.19 and p < 0.05; t(28) = 2.23 and p < 0.05], but only for Twin 2. Finally, the results showed that mothers' perceptions of child temperament

  5. Parental Relationship with Twins from Pregnancy to 3 Months: The Relation Among Parenting Stress, Infant Temperament, and Well-Being

    PubMed Central

    Prino, Laura E.; Rollè, Luca; Sechi, Cristina; Patteri, Luciana; Ambrosoli, Anna; Caldarera, Angela M.; Gerino, Eva; Brustia, Piera

    2016-01-01

    Objective: The transition to parenthood, from pregnancy to postpartum period, is a critical process, particularly for couples expecting twins. There is very little literature regarding the links between anxiety, depression, dyadic adjustment, parental stress, and infant temperament spanning from pregnancy to postpartum. This study has two aims: first, to examine whether mothers’ and fathers’ anxiety, depression, and dyadic adjustment, assessed at the sixth month of pregnancy and 3 months postpartum, are associated with infants’ negative affectivity (NA) and parenting stress; second, to examine whether there is any difference between fathers’ and mothers’ levels of parenting stress and perception of the twins’ temperament, as well as to evaluate, separately for mothers and fathers, whether the levels of parenting stress and perception of child temperament differ for each twin. Method: The study participants were 58 parents (29 couples) and their healthy 58 twin babies (51.7% boys, 48.3% girls). Mothers’ ages ranged from 30 to 44 years, (MAge = 36.3 years, SD = 3.2 years), and fathers’ ages ranged from 32 to 52 years, (MAge = 38.2 years, SD = 4.4 years). The parents, during the pregnancy period and 3 months after delivery, filled out the Edinburgh Postnatal Depression Scale, the State-Trait Anxiety Inventory, and the Dyadic Adjustment Scale. Three months after delivery they also filled out the Parenting Stress Index—Short Form and the Infant Behavior Questionnaire Revised. Results: The analyses showed a significant correlation between parental anxiety/depression symptoms and infants’ NA and parenting stress (in both mothers and fathers). Moreover, compared to fathers, mothers reported higher scores on specific dimensions of the infants’ NA, [t(28) = -2.62 and p < 0.05; t(28) = 2.09 and p < 0.05], and parenting stress, [t(28) = 2.19 and p < 0.05; t(28) = 2.23 and p < 0.05], but only for Twin 2. Finally, the results showed that mothers

  6. Cortisol reactivity, maternal sensitivity, and learning in 3-month-old infants.

    PubMed

    Thompson, Laura A; Trevathan, Wenda R

    2008-01-01

    This study investigated the effects of adrenocortical functioning on infant learning during an emotionally challenging event (brief separation from mother). We also explored possible relationships between maternal sensitivity and both infant and maternal cortisol reactivity during the learning/maternal separation episode. Sixty-three 3-month-olds and their mothers were videotaped for a 10 min normal interaction period, and mother-infant behavioral synchrony was measured using Isabella and Belsky's [Isabella, R. A., & Belsky, J. (1991). Interactional synchrony and the origins of infant-mother attachment: A replication study. Child Development, 62, 373-384] coding scheme. The percentage of synchronous behaviors served as a measure of maternal sensitivity. Learning and short-term memory involved relating the infant's mother's voice with a moving colored block in a preferential looking paradigm. Infants whose cortisol increased during the session showed no learning or memory, infants whose cortisol declined appeared to learn and remember the association, while infants whose cortisol did not change evidenced learning, but not memory for the voice/object correspondence. Sensitivity and cortisol reactivity were correlated for mothers, but not for infants. Infant and maternal cortisol values for the first sampling period were highly correlated, but their cortisol reactivity values were uncorrelated, supporting the notion that infants and mothers have coordinated adrenocortical functioning systems when physically together, but become uncoordinated during a separation/learning event.

  7. Feasibility of sequential adjuvant chemotherapy with a 3-month oxaliplatin-based regimen followed by 3 months of capecitabine in patients with stage III and high-risk stage II colorectal cancer: JSWOG-C2 study

    PubMed Central

    Tsuruta, Atsushi; Yamashita, Kazuki; Tanioka, Hiroaki; Tsuji, Akihito; Inukai, Michio; Yamakawa, Toshiki; Yamatsuji, Tomoki; Yoshimitsu, Masanori; Toyota, Kazuhiro; Yamano, Taketoshi; Nagasaka, Takeshi; Okajima, Masazumi

    2016-01-01

    Background Six months of oxaliplatin-based chemotherapy is the standard adjuvant chemotherapy for completely resected stage III colorectal cancer (CRC). Also, patients with stage II CRC who are considered to be at high risk of disease recurrence often receive the same adjuvant chemotherapy treatment. We prospectively investigated the extent and degree of neuropathy suffered by stage III and high-risk stage II resectable CRC patients who underwent sequential approach involving 3 months of an oxaliplatin-based regimen followed by 3 months of capecitabine. Patients and methods Patients with completely resected stage III and high-risk stage II CRC aged ≥20 years were eligible. Patients were treated with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) or capecitabine and oxaliplatin (CAPOX) for 3 months followed by capecitabine (2,500 mg/m2 on days 1–14 every 3 weeks) for 3 months. Primary end points were frequency and the grade of oxaliplatin-induced neurotoxicity as evaluated using the physician-based Common Terminology Criteria for Adverse Events version 4.0 (CTCAE) grading and the patient-based scale, self-reported Patient Neurotoxicity Questionnaire. Results Ninety-one patients were enrolled and 86 patients assessed. Eighty-four percent of patients completed the planned oxaliplatin-based therapy for 3 months, and 63% of patients completed all treatments for the full 6 months. Overall incidences of grade 3 or 4 peripheral sensory or motor neuropathy according to the CTCAE were 3.5% and 1.2%, respectively. Regarding the peripheral sensory neuropathy, the proportion of Patient Neurotoxicity Questionnaire (grade C–E) and CTCAE (grade 2–4) at months 1.5/3/6 were 11.3/22.1/29.4% and 5.3/4.4/11.3%, respectively (Spearman correlation coefficient: 0.47). Conclusion A sequential approach to adjuvant chemotherapy with 3 months of an oxaliplatin-based regimen followed by 3 months of capecitabine was tolerated by patients and associated with a low incidence of

  8. Plasma Neutrophil Gelatinase-Associated Lipocalin as a Marker for Prediction of 3-Month Graft Survival after Kidney Transplantation

    PubMed Central

    Jafari, A.; Khatami, M. R.; Dashti-Khavidaki, S.; Lessan-Pezeshki, M.; Abdollahi, A.

    2017-01-01

    Background: Ischemic injury during organ transplantation increases the risk of acute and chronic rejections by promoting alloimmune responses. Measurement of neutrophil gelatinase-associated lipocalin (NGAL) immediately after kidney transplantation may be promising for early detection of ischemic injuries to allograft. Objective: This study assessed possible predictive values of plasma NGAL levels during first hours after kidney transplantation for graft loss within the first 3 months after transplantation. Methods: 45 kidney transplant recipients were classified into those without graft loss or with graft loss during 3 months after transplantation. Plasma NGAL levels were measured before and at 2, 6, 12, 24 and 96 hours after transplantation. Serum creatinine concentration was assessed daily during hospitalization and at 1, 2, and 3 months post-transplantation. Results: Serum creatinine and plasma NGAL levels were consistently higher in patients with graft loss compared with those without graft loss. At 2, 24, and 96 hours after transplantation, plasma NGAL concentration was significantly higher in patients who developed allograft loss within 3 months post-transplantation. The cutoff point of plasma NGAL at 2, 24, and 96 hours after transplantation for prediction of graft loss was 304.5 ng/mL (sensitivity of 71.4%, and specificity of 73.7%), 207.8 ng/mL(sensitivity of 85.7%, and specificity of 60.5%), and 184 ng/mL (sensitivity of 85.7%, and specificity of 71.1%), respectively. Conclusion: Plasma NGAL levels at 2, 24, and 96 hours after transplantation can predict 3-month graft loss with fair sensitivity and specificity. PMID:28299024

  9. Jointly structuring triadic spaces of meaning and action: book sharing from 3 months on

    PubMed Central

    Rossmanith, Nicole; Costall, Alan; Reichelt, Andreas F.; López, Beatriz; Reddy, Vasudevi

    2014-01-01

    This study explores the emergence of triadic interactions through the example of book sharing. As part of a naturalistic study, 10 infants were visited in their homes from 3–12 months. We report that (1) book sharing as a form of infant-caregiver-object interaction occurred from as early as 3 months. Using qualitative video analysis at a micro-level adapting methodologies from conversation and interaction analysis, we demonstrate that caregivers and infants practiced book sharing in a highly co-ordinated way, with caregivers carving out interaction units and shaping actions into action arcs and infants actively participating and co-ordinating their attention between mother and object from the beginning. We also (2) sketch a developmental trajectory of book sharing over the first year and show that the quality and dynamics of book sharing interactions underwent considerable change as the ecological situation was transformed in parallel with the infants' development of attention and motor skills. Social book sharing interactions reached an early peak at 6 months with the infants becoming more active in the coordination of attention between caregiver and book. From 7 to 9 months, the infants shifted their interest largely to solitary object exploration, in parallel with newly emerging postural and object manipulation skills, disrupting the social coordination and the cultural frame of book sharing. In the period from 9 to 12 months, social book interactions resurfaced, as infants began to effectively integrate manual object actions within the socially shared activity. In conclusion, to fully understand the development and qualities of triadic cultural activities such as book sharing, we need to look especially at the hitherto overlooked early period from 4 to 6 months, and investigate how shared spaces of meaning and action are structured together in and through interaction, creating the substrate for continuing cooperation and cultural learning. PMID:25540629

  10. Ultra-Short-Period Planets in K2: New Results From SuPerPiG

    NASA Astrophysics Data System (ADS)

    Adams, Elisabeth; Jackson, Brian; Endl, Michael

    2016-10-01

    Ultra-short-period planets, with orbital periods of less than 1 day, are a challenge to theories of planet formation. The SuPerPiG collaboration (Short-Period Planet Group) reports on 19 candidates identified in Campaigns 0-5 of the K2 mission. Planet candidates range in size from 0.7-16 Earth radii and in orbital period from 4.2 to 23.5 hours. One candidate (EPIC 203533312, Kp=12.5) is among the shortest-period planet candidates discovered to date (P=4.2 hours), and, if confirmed as a planet, must have a density of at least rho=8.9 g/cm^3 in order to not be tidally disrupted. Five candidates have nominal radius values in the sub-Jovian desert (R_P=3-11 R_E and P<=1.5 days) where theoretical models do not favor their long-term stability; the only confirmed planet in this range is thought to be disintegrating (EPIC 201637175). Based on an assessment of our survey's completeness, we estimate an occurrence rate for ultra-short-period planets among K2 target stars that is about half that estimated from the Kepler sample, raising questions as to whether K2 systems are intrinsically different from Kepler systems, possibly as a result of their different galactic location.

  11. Influence of 3 months endurance training on red cell deformability in non insulin dependent type 2 diabetes mellitus patients.

    PubMed

    Ahmad, B; Opitz, D; Bloch, W; Brixius, K

    2013-08-01

    The main purpose of the study was to examine if 3 months of bicycle endurance training alters the red cell deformability in non insulin dependent type 2 diabetes mellitus men.The red cell deformability was measured with the Laser assisted optical rotational cell analyzer. The maximal elongation index and the semimaximal shear stress were measured with the Lineweaver Burke model.At the beginning and the end of the intervention the patients passed a bicycle ergometry test. As a reference group, 13 males without diabetes passed the same testing procedure. Blood samplings were taken before testing, immediately after physical exhaustion and after a 30 min recovery phase.After the training period diabetic patients could significantly reduce BMI, fasting glucose and HbA1c. The reference group had significantly higher elongation indices than the diabetes patients independent from training status. After the training period the basal values of the maximal elongation index did not change significantly. However, maximal elongation indices were significantly reduced after physical examination and in resting time.The semimaximal shear stress of diabetes patients did not alter during the training period. In comparison to the reference group semimaximal shear stress was significantly reduced at all measurement times.This pilot study proves that the maximal elongation index is significantly decreased in diabetes mellitus patients. After 3 months endurance training the red cells become more rigid while the semimaximal shear stress remains constant. Further interventions are required to analyze the exact cause of the presented findings.

  12. Inadequacy of 3-month Oswestry Disability Index outcome for assessing individual longer-term patient experience after lumbar spine surgery.

    PubMed

    Asher, Anthony L; Chotai, Silky; Devin, Clinton J; Speroff, Theodore; Harrell, Frank E; Nian, Hui; Dittus, Robert S; Mummaneni, Praveen V; Knightly, John J; Glassman, Steven D; Bydon, Mohamad; Archer, Kristin R; Foley, Kevin T; McGirt, Matthew J

    2016-08-01

    OBJECTIVE Prospective longitudinal outcomes registries are at the center of evidence-driven health care reform. Obtaining real-world outcomes data at 12 months can be costly and challenging. In the present study, the authors analyzed whether 3-month outcome measurements sufficiently represent 12-month outcomes for patients with degenerative lumbar disease undergoing surgery. METHODS Data from 3073 patients undergoing elective spine surgery for degenerative lumbar disease were entered into a prospective multicenter registry (N(2)QOD). Baseline, 3-month, and 12-month follow-up Oswestry Disability Index (ODI) scores were recorded. The absolute differences between actual 12- and 3-month ODI scores was evaluated. Additionally, the authors analyzed the absolute difference between actual 12-month ODI scores and a model-predicted 12-month ODI score (the model used patients' baseline characteristics and actual 3-month scores). The minimal clinically important difference (MCID) for ODI of 12.8 points and the substantial clinical benefit (SCB) for ODI of 18.8 points were used based on the previously published values. The concordance rate of achieving MCID and SCB for ODI at 3-and 12-months was computed. RESULTS The 3-month ODI scores differed from 12-month scores by an absolute difference of 11.9 ± 10.8, and predictive modeling estimations of 12-month ODI scores differed from actual 12-month scores by a mean (± SD) of 10.7 ± 9.0 points (p = 0.001). Sixty-four percent of patients (n = 1982) achieved an MCID for ODI at 3 months in comparison with 67% of patients (n = 2088) by 12 months; 51% (n = 1731) and 61% (n = 1860) of patients achieved SCB for ODI at 3 months and 12 months, respectively. Almost 20% of patients had ODI scores that varied at least 20 points (the point span of an ODI functional category) between actual 3- and 12-month values. In the aggregate analysis of achieving MCID, 77% of patients were concordant and 23% were discordant in achieving or not achieving

  13. Plasticity of visual attention in Isha yoga meditation practitioners before and after a 3-month retreat.

    PubMed

    Braboszcz, Claire; Cahn, B Rael; Balakrishnan, Bhavani; Maturi, Raj K; Grandchamp, Romain; Delorme, Arnaud

    2013-01-01

    Meditation has lately received considerable interest from cognitive neuroscience. Studies suggest that daily meditation leads to long lasting attentional and neuronal plasticity. We present changes related to the attentional systems before and after a 3 month intensive meditation retreat. We used three behavioral psychophysical tests - a Stroop task, an attentional blink task, and a global-local letter task-to assess the effect of Isha yoga meditation on attentional resource allocation. 82 Isha yoga practitioners were tested at the beginning and at the end of the retreat. Our results showed an increase in correct responses specific to incongruent stimuli in the Stroop task. Congruently, a positive correlation between previous meditation experience and accuracy to incongruent Stroop stimuli was also observed at baseline. We also observed a reduction of the attentional blink. Unexpectedly, a negative correlation between previous meditation experience and attentional blink performance at baseline was observed. Regarding spatial attention orientation as assessed using the global-local letter task, participants showed a bias toward local processing. Only slight differences in performance were found pre- vs. post- meditation retreat. Biasing toward the local stimuli in the global-local task and negative correlation of previous meditation experience with attentional blink performance is consistent with Isha practices being focused-attention practices. Given the relatively small effect sizes and the absence of a control group, our results do not allow clear support nor rejection of the hypothesis of meditation-driven neuronal plasticity in the attentional system for Isha yoga practice.

  14. Prescription patterns of analgesics in the last 3 months of life: a retrospective analysis of 10202 lung cancer patients

    PubMed Central

    Gao, W; Gulliford, M; Higginson, I J

    2011-01-01

    Background: To describe the prescription patterns of analgesics during the last 3 months of life in lung cancer and to determine the associated factors. Methods: Data on lung cancer patients (N=10 202) who died during 2000–2008 were extracted from the General Practice Research Database (GPRD). This database records prescriptions of patients received from UK general practices (GP), but not those from non-GP routes. Prescription prevalences were estimated. The associated factors were investigated using log-binomial regression. Results: The overall prescription prevalences were 50.4% (95% confidence interval (CI): 49.4–51.4%) for level 1 (e.g., paracetamol), 34.1% (95% CI: 33.2–35.0%) for level 2 (weak opioids), and 55.5 % (95% CI: 54.5–56.4%) for level 3 analgesics (strong opioids). Prescription prevalence of analgesics of all levels showed an increasing trend over the period 2000–2008 (annual increases range: 1.1–1.5%) but a decreasing trend with age (average decrease per group range: −5.8 to −1.8%). Patients in the older age groups were less likely to be prescribed level 3 analgesics than those in the younger age groups (PR‘90+' vs ‘<50'=0.55 (95% CI: 0.45–0.67); PR‘80−89' vs ‘<50'=0.73 (95% CI: 0.66–0.79); PR‘70−79' vs ‘<50'=0.84 (95% CI: 0.77–0.90)). Conclusion: Analgesics have been increasingly prescribed in lung cancer. However, analgesics, especially at level 3, were relatively under-prescribed to people older than 70 years, warranting further investigation. PMID:21540860

  15. In the first 3 months after stroke is progressive resistance training safe and does it improve activity? A systematic review.

    PubMed

    Salter, Karen; Musovic, Amie; F Taylor, Nicholas

    2016-10-01

    BACKGROUND Progressive resistance training (PRT) can improve strength and function in people with chronic stroke, but less is known about whether this intervention is safe and beneficial during the first 3 months following stroke. OBJECTIVE To systematically review the evidence about the safety and effectiveness of PRT to improve activity in people within the first 3 months after stroke. METHODS After database searching and selection of studies a risk of bias assessment was conducted. Data for the primary outcome of safety was synthesised descriptively and meta-analyses for other outcomes were conducted using a random effects model. RESULTS The quality of the 5 included studies ranged from good to excellent (mean 24.2, range 20-28). For the trials investigating adverse events, none reported any significant increase in events after PRT. There was high level evidence that PRT had little or no effect on strength (SMD (standardized mean difference) 0.17, 95% CI -0.16 to 0.50, I(2) = 0%). There were no significant benefit for upper limb function (SMD 0.11, 95% CI -0.41 to 0.63, I(2) = 0%) and mobility (SMD 0.11, 95% CI -0.21 to 0.43, I(2) = 27%) after PRT compared with controls. CONCLUSIONS There was no evidence reported that PRT is unsafe in people within the first 3 months after stroke, although there was a lack of reporting about adverse events. The lack of demonstration of effect in improving muscle strength and activity suggests there is insufficient evidence to recommend the prescription of PRT for people within the first 3 months after stroke.

  16. Results of Laboratory and Industrial Tests of Periodic-Type Gas Generators

    NASA Astrophysics Data System (ADS)

    Karp, I. N.; P‧yanykh, K. E.; Antoshchuk, T. A.; Lysenko, A. A.

    2015-05-01

    Results of laboratory and industrial tests of periodic-type gas generators burning various solid biofuels have been presented. The tests were carried out with the aim of obtaining producer gas which could totally or partly replace natural gas in power equipment burning gaseous fuel. The energy and environmental characteristics of a boiler unit burning a mixture of producer gas and natural gas have been assessed.

  17. Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months.

    PubMed

    Arts, Josje H E; Muijser, Hans; Duistermaat, Evert; Junker, Karin; Kuper, C Frieke

    2007-10-01

    persistent and toxicological effects differed from those seen with SAS both with regard to the type and severity as well as in the time-response profile. In quartz-exposed animals silicon in the tracheobronchial lymph nodes was below the detection limit but silicon was found in the lungs at comparable levels 0-, 1- and 3-months post-exposure. One-day post-exposure to quartz, elevations in biomarkers of cytotoxicity in BALf, increases in lung and tracheobronchial lymph node weight and histopathological lung changes were minimal. These effects were present at 1-month post-exposure and progressively more severe at 3-months post-exposure. Overall, the results of the current study are similar to those of other published studies that had a 90-day exposure period and both types of studies indicate that the lack of lung clearance is a key factor in the development of silicosis.

  18. Periodic inspection on crop sprayers: results according to age of sprayers.

    PubMed

    Antuniassi, Ulisses R; Gandolfo, Marco A

    2005-01-01

    The objectives of the IPP Project--Periodic Inspection on Crop Sprayers--are to develop methods for sprayer certification, analyze quality on spray operation, propose an inspection system for crop sprayers in Brazil, improve environmental quality on spray operation, and reduce costs on chemical control for plant protection systems. Periodic inspections on crop sprayers are performed in several countries and are compulsory in most of them, and it is becoming an important tool for improvement and optimization of use of chemicals. The IPP Project in Brazil is funded by FAPESP--Fundação de Amparo à Pesquisa do Estado de São Paulo. The results so far showed that all the sprayers presented failures. However, most of them could be approved with minor services. As an example, 56.6% of the sprayers with more than 2 years of use presented leaks, 47% of them had damaged hoses and 80.5% presented bad tips (nozzles). These results indicate the need for better procedures of use and maintenance of sprayers, justifying the periodic inspection system.

  19. Mental Rotation of Dynamic, Three-Dimensional Stimuli by 3-Month-Old Infants

    ERIC Educational Resources Information Center

    Moore, David S.; Johnson, Scott P.

    2011-01-01

    Mental rotation involves transforming a mental image of an object so as to accurately predict how the object would look if it were rotated in space. This study examined mental rotation in male and female 3-month-olds, using the stimuli and paradigm developed by Moore and Johnson (2008). Infants were habituated to a video of a three-dimensional…

  20. Stability and Changes in Sleep Regulation: A Longitudinal Study from 3 Months to 3 Years

    ERIC Educational Resources Information Center

    Scher, Anat; Epstein, Rachel; Tirosh, Emmanuel

    2004-01-01

    The goal of the study was to examine the developmental course of sleep consolidation from infancy to preschool. The sleep of 50 healthy infants aged 3 months was recorded, at home, with actigraphs (computerised activity monitors). Follow-up recordings were carried out at 6, 9, 12, 20, and 42 months (due to attrition and occasional technical…

  1. The Face Perception System becomes Species-Specific at 3 Months: An Eye-Tracking Study

    ERIC Educational Resources Information Center

    Di Giorgio, Elisa; Meary, David; Pascalis, Olivier; Simion, Francesca

    2013-01-01

    The current study aimed at investigating own- vs. other-species preferences in 3-month-old infants. The infants' eye movements were recorded during a visual preference paradigm to assess whether they show a preference for own-species faces when contrasted with other-species faces. Human and monkey faces, equated for all low-level perceptual…

  2. Positive, but Not Negative, Facial Expressions Facilitate 3-Month-Olds' Recognition of an Individual Face

    ERIC Educational Resources Information Center

    Brenna, Viola; Proietti, Valentina; Montirosso, Rosario; Turati, Chiara

    2013-01-01

    The current study examined whether and how the presence of a positive or a negative emotional expression may affect the face recognition process at 3 months of age. Using a familiarization procedure, Experiment 1 demonstrated that positive (i.e., happiness), but not negative (i.e., fear and anger) facial expressions facilitate infants' ability to…

  3. A Smile Enhances 3-Month-Olds' Recognition of an Individual Face

    ERIC Educational Resources Information Center

    Turati, Chiara; Montirosso, Rosario; Brenna, Viola; Ferrara, Veronica; Borgatti, Renato

    2011-01-01

    Recent studies demonstrated that in adults and children recognition of face identity and facial expression mutually interact (Bate, Haslam, & Hodgson, 2009; Spangler, Schwarzer, Korell, & Maier-Karius, 2010). Here, using a familiarization paradigm, we explored the relation between these processes in early infancy, investigating whether 3-month-old…

  4. Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays

    PubMed Central

    Amin, Hayder; Maccione, Alessandro; Marinaro, Federica; Zordan, Stefano; Nieus, Thierry; Berdondini, Luca

    2016-01-01

    The recent availability of human induced pluripotent stem cells (hiPSCs) holds great promise as a novel source of human-derived neurons for cell and tissue therapies as well as for in vitro drug screenings that might replace the use of animal models. However, there is still a considerable lack of knowledge on the functional properties of hiPSC-derived neuronal networks, thus limiting their application. Here, upon optimization of cell culture protocols, we demonstrate that both spontaneous and evoked electrical spiking activities of these networks can be characterized on-chip by taking advantage of the resolution provided by CMOS multielectrode arrays (CMOS-MEAs). These devices feature a large and closely-spaced array of 4096 simultaneously recording electrodes and multi-site on-chip electrical stimulation. Our results show that networks of human-derived neurons can respond to electrical stimulation with a physiological repertoire of spike waveforms after 3 months of cell culture, a period of time during which the network undergoes the expression of developing patterns of spontaneous spiking activity. To achieve this, we have investigated the impact on the network formation and on the emerging network-wide functional properties induced by different biochemical substrates, i.e., poly-dl-ornithine (PDLO), poly-l-ornithine (PLO), and polyethylenimine (PEI), that were used as adhesion promoters for the cell culture. Interestingly, we found that neuronal networks grown on PDLO coated substrates show significantly higher spontaneous firing activity, reliable responses to low-frequency electrical stimuli, and an appropriate level of PSD-95 that may denote a physiological neuronal maturation profile and synapse stabilization. However, our results also suggest that even 3-month culture might not be sufficient for human-derived neuronal network maturation. Taken together, our results highlight the tight relationship existing between substrate coatings and emerging network

  5. Electrical Responses and Spontaneous Activity of Human iPS-Derived Neuronal Networks Characterized for 3-month Culture with 4096-Electrode Arrays.

    PubMed

    Amin, Hayder; Maccione, Alessandro; Marinaro, Federica; Zordan, Stefano; Nieus, Thierry; Berdondini, Luca

    2016-01-01

    The recent availability of human induced pluripotent stem cells (hiPSCs) holds great promise as a novel source of human-derived neurons for cell and tissue therapies as well as for in vitro drug screenings that might replace the use of animal models. However, there is still a considerable lack of knowledge on the functional properties of hiPSC-derived neuronal networks, thus limiting their application. Here, upon optimization of cell culture protocols, we demonstrate that both spontaneous and evoked electrical spiking activities of these networks can be characterized on-chip by taking advantage of the resolution provided by CMOS multielectrode arrays (CMOS-MEAs). These devices feature a large and closely-spaced array of 4096 simultaneously recording electrodes and multi-site on-chip electrical stimulation. Our results show that networks of human-derived neurons can respond to electrical stimulation with a physiological repertoire of spike waveforms after 3 months of cell culture, a period of time during which the network undergoes the expression of developing patterns of spontaneous spiking activity. To achieve this, we have investigated the impact on the network formation and on the emerging network-wide functional properties induced by different biochemical substrates, i.e., poly-dl-ornithine (PDLO), poly-l-ornithine (PLO), and polyethylenimine (PEI), that were used as adhesion promoters for the cell culture. Interestingly, we found that neuronal networks grown on PDLO coated substrates show significantly higher spontaneous firing activity, reliable responses to low-frequency electrical stimuli, and an appropriate level of PSD-95 that may denote a physiological neuronal maturation profile and synapse stabilization. However, our results also suggest that even 3-month culture might not be sufficient for human-derived neuronal network maturation. Taken together, our results highlight the tight relationship existing between substrate coatings and emerging network

  6. Temporal Trends of Suicide Mortality in Mainland China: Results from the Age-Period-Cohort Framework

    PubMed Central

    Wang, Zhenkun; Wang, Jinyao; Bao, Junzhe; Gao, Xudong; Yu, Chuanhua; Xiang, Huiyun

    2016-01-01

    The aim of this study is to explore the long-term trends of suicide mortality in China. We implemented the age-period-cohort (APC) framework, using data from the Global Burden of Disease Study 2013. Our results showed that the net drift of suicide mortality was −4.727% (95% CI: −4.821% to −4.634%) per year for men and −6.633% (95% CI: −6.751% to −6.515%) per year for women, and the local drift values were below 0 in all age groups (p < 0.01 for all) for both sexes during the period of 1994–2013. Longitudinal age curves indicated that, in the same birth cohort, suicide death risk increased rapidly to peak at the life stage of 20–24 years old and 15–24 years old for men and women, respectively, and then showed a decelerated decline, followed by a rise thereafter after 54 years old for men and a slight one after 69 years old for women. The estimated period and cohort RRs were found to show similar monotonic downward patterns (significantly with p < 0.01 for all) for both sexes, with more quickly decreasing for women than for men during the whole period. The decreasing trend of suicide was likely to be related to the economic rapid growth, improvements in health care, enhancement on the level of education, and increasing awareness of suicide among the public in China. In addition, fast urbanization and the effective control of pesticides and rodenticides might be the special reasons behind these trends we observed in this study. PMID:27527195

  7. The BREASTrial Stage II: ADM Breast Reconstruction Outcomes from Definitive Reconstruction to 3 Months Postoperative

    PubMed Central

    Mendenhall, Shaun D.; Anderson, Layla A.; Ying, Jian; Boucher, Kenneth M.; Neumayer, Leigh A.

    2017-01-01

    Background: The Breast Reconstruction Evaluation of Acellular Dermal Matrix as a Sling Trial is a prospective randomized trial comparing outcomes of tissue expander breast reconstruction using either AlloDerm or DermaMatrix. The trial was divided into 3 outcome stages; this study reports stage II outcomes, which are those from the time of definitive reconstruction to 3 months postoperative. Methods: A randomized trial was conducted to compare complication rates between AlloDerm and DermaMatrix groups. The impact of matrix type, age, obesity, radiation therapy, chemotherapy, and reconstruction type on complications was analyzed with regression models. Results: Of the 128 patients (199 breasts) who were randomly assigned into the trial, 111 patients (173 breasts) were available for analysis in stage II. There was no difference in overall rates of complications (15.4% vs 18.3%, P = 0.8) or implant loss (2.2% vs 3.7%, P = 0.5) between the AlloDerm and DermaMatrix groups, respectively. Obesity was the only significant predictor of complications on regression analysis (odds ratio, 4.31, P = 0.007). Matrix type, age, radiation therapy, chemotherapy, or reconstruction type had no impact on the incidence/severity of complications. Conclusions: Acellular dermal matrix (ADM) will likely continue to have a role in breast reconstructive surgery; however, caution should be taken when using ADM because of relatively high complication rates, especially in obese patients. The particular ADM product should be selected based on individual surgeon preference, experience, and success rates. These data and forthcoming long-term outcomes from the Breast Reconstruction Evaluation of Acellular Dermal Matrix as a Sling Trial will enable surgeons to carefully weigh the risks and benefits of ADM use in breast reconstruction. PMID:28203509

  8. Assesment of perinatal mortality in two different periods: results of a single center

    PubMed Central

    Duran, Serdar Sadık; Kavuncuoğlu, Sultan; Sarı, Ferhat; Aldemir, Esin Yıldız; Kavçık, Nazlı; Demir, Ferhat

    2016-01-01

    Aim: This study aimed to investigate the perinatal mortality rate with 37 864 deliveries which occured in two different periods in a single center, to compare the components of perinatal mortality and affecting factors with the results of the study related with perinatal mortality which we conducted in 1999 and to emphasize the precautions directed to reduce mortality rates. Material and Methods: All live births and stillbirths which occurred in Bakırköy Obstetrics and Pediatrics Training and Research Hospital between January 2007 and December 2007 were evaluated. The results were compared with the results of the study conducted in 1999. Newborns with a weight above five hundred grams and a gestational age above 22 weeks were enrolled in the study. The stillbirth rate, early neonatal mortality rate, late neonatal mortality rate, perinatal mortality rate and corrected perinatal mortality rate were calculated. Modified Wigglesworth Classification was used for evaluating the perinatal mortality and the subjects were examined in 7 groups. The characteristics belonging to the years of 2007 and 1999 were examined, the differences were recorded and the results were discussed. When the two periods were compared, it was observed that the perinatal mortality rate increased from 23.5‰ to 26‰. Result: When the causes were investigated, it was observed that the stillbirth rate was increased in 2007 (84%) and especially congenital anomalies had an important role in this increment. The early neonatal mortality rate declined from 0.8% in 1999 to 0.4% in 2007. It was found that especially the premature mortality rate (Group 3) and the mortality rate related with perinatal asphyxia (Group 4) were significantly decreased. Conclusion: The decrease in early neonatal mortality rate could be best explained by productive operation of the new neonatal intensive care unit which had been established after 2002. PMID:27738396

  9. 42 CFR 412.76 - Recovery of excess transition period payment amounts resulting from unlawful claims.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 2 2010-10-01 2010-10-01 false Recovery of excess transition period payment... INPATIENT HOSPITAL SERVICES Determination of Transition Period Payment Rates for the Prospective Payment System for Inpatient Operating Costs § 412.76 Recovery of excess transition period payment...

  10. Schistosoma mansoni Infection 3 Months after Praziquantel Therapy Among Farmers in Qalyub, Egypt

    DTIC Science & Technology

    1993-05-01

    REPORT TYPE AND DATES COVERED 1993 I - 4.-11I-C- A/" SUBDIIILE 5. FUNDING NUMBERS Schistosoma mansoni Infection 3 Months after Praziquantel Therapy PE...region of the Nile Delta. Treatment with praziquantel at the recommended dose 40 mg/kg body weight in a single oral dose was taken by 668 (87%) of...to evaluate optimal dosage of praziquantel and sequential treatment schedules to achieve effective control of transmission are indicated. 14. SUBJECT

  11. Bipolar radiofrequency ablation of benign thyroid nodules using a multiple overlapping shot technique in a 3-month follow-up.

    PubMed

    Kohlhase, Konstantin David; Korkusuz, Yücel; Gröner, Daniel; Erbelding, Christian; Happel, Christian; Luboldt, Wolfgang; Grünwald, Frank

    2016-08-01

    Purpose The aim of this study was to evaluate the decrease of benign thyroid nodules after bipolar radiofrequency ablation (RFA) in a 3-month follow-up using a multiple overlapping shot technique ('MOST'). Methods A total of 18 patients with 20 symptomatic benign thyroid nodules (17 cold nodules, 3 hyperfunctioning nodules) were treated in one single session by bipolar RFA. Bipolar ablation was performed using MOST. The nodule volumes were measured prior to ablation and 3 months after the procedure using ultrasound. The population consisted of either solid (>80% solid tissue within the volume of interest), complex, or cystic nodules (<20% solid tissue within the volume of interest). Results Bipolar RFA resulted in a highly significant (p < 0.0001) decrease of nodule volume (ΔV), median 5.3 mL (range 0.13-43.1 mL), corresponding to a relative reduction in mean of 56 ± 17.9%. Median initial volume was 8 mL (range 0.48-62 mL); 3 months after ablation a median volume of 2.3 mL (range 0.3-32 mL) was measured. Nodule growth ≥50% occurred in 70% (14 nodules). At the follow-up no complications such as infections, persisting pain, nerve injuries or immunogen stimulation occurred. Patients with cold nodules (15) remained euthyroid, with hyperfunctioning nodules either euthyroid (2) or latent hypofunctional (1). Conclusion The use of bipolar RFA is an effective, safe and suitable thermoablative technique to treat benign thyroid nodules. Combined with the multiple overlapping shot technique it allows sufficient ablation.

  12. Evaporation over land surfaces - First results from HAPEX-MOBILHY Special Observing Period

    NASA Technical Reports Server (NTRS)

    Andre, Jean-Claude; Goutorbe, Jean-Paul; Bessemoulin, Pierre; Perrier, Alain; Becker, Francois

    1988-01-01

    Preliminary results are presented from the May 7-July 15, 1986 Special Observing Period (SOP) of the HAPEX-MOBILHY program, which examines the hydrological budget and evaporation flux at the scale of a 10,000 sq km GCM grid square to determine soil moisture, surface-energy budgets, and surface hydrology. The SOP used two highly instrumented remote sensing aircraft to obtain detailed measurements of atmospheric fluxes and surface properties. It is noted that the measurements are reliable at spatially local and short time scales, as well as on the monthly time scale. The data base obtained may be used in parametrization schemes against which land-surface water budgets can be tested.

  13. Patch-test results in children and adolescents: systematic review of a 15-year period*

    PubMed Central

    Rodrigues, Dulcilea Ferraz; Goulart, Eugênio Marcos Andrade

    2016-01-01

    The number of studies on patch-test results in children and adolescents has gradually increased in recent years, thus stimulating reviews. This paper is a systematic review of a 15-year period devoted to studying the issue. Variations pertaining to the number and age groups of tested children and/or adolescents, the number of subjects with atopy/atopic dermatitis history, the quantity, type and concentrations of the tested substances, the test technique and type of data regarding clinical relevance, must all be considered in evaluating these studies, as they make it harder to formulate conclusions. The most common allergens in children were nickel, thimerosal, cobalt, fragrance, lanolin and neomycin. In adolescents, they were nickel, thimerosal, cobalt, fragrance, potassium dichromate, and Myroxylon pereirae. Knowledge of this matter aids health professionals in planning preventive programs aimed at improving children's quality of life and ensuring that their future prospects are not undermined. PMID:26982781

  14. Observed coparenting and triadic dynamics in African American fragile families at 3 months' postpartum.

    PubMed

    McHale, James P; Coates, Erica E

    2014-01-01

    This report examines coparenting and triadic interactions in 19 unmarried, first-time African American families as fathers, mothers, and 3-month-old infants navigated the Lausanne Trilogue Play (LTP; E. Fivaz-Depeursinge & A. Corboz-Warnery, ). Parents in 10 of the 19 families reported coresidence at the time of the 3-month assessment, and the other 9 sets of coparents lived apart. All participating families had taken part in a prenatal intervention emphasizing the importance of father engagement in children's lives, and in all families, parents reported episodic to regular father contact with the children at 3 months. Analyses of LTP sessions revealed that 9 of the 19 families exhibited high levels of coparenting solidarity-cooperation and family warmth accompanied by low levels of coparenting competition and disengagement. Among the remaining 10 families, competitiveness (verbal sparring, interference) and/or disengagement (repeated, episodic absenting by one or both parents from the ongoing interaction) signaled strain and challenges to solidarity. Differences between the higher and lower solidarity groups were found in father-reported relationship rapport. However, coresidentiality versus noncoresidentiality of the parents did not distinguish high- from low-solidarity groups. A case analysis of one family's triadic session is presented to elucidate the rich potential for clinical intervention in triadic work with fragile family systems. Implications of the study and its findings for theory, research, and clinical work with unmarried fathers and families, along with limits of the study design and generalizability of findings, are discussed.

  15. Postnatal depression among Sudanese women: prevalence and validation of the Edinburgh Postnatal Depression Scale at 3 months postpartum

    PubMed Central

    Khalifa, Dina Sami; Glavin, Kari; Bjertness, Espen; Lien, Lars

    2015-01-01

    Purpose Postnatal depression (PND) rates in low-resource countries have reached levels between 4.9% and 59%. Maternal mental health has not been researched in Sudan, and there are no existing statistics on prevalence or significant risk factors for PND. Consequently, no screening test has been validated to screen for PND at the primary health care level. This study investigates the 3 months prevalence of PND and validates the Edinburgh Postnatal Depression Scale (EPDS) against the Mini-International Neuropsychiatric Interview (MINI). Methodology Pregnant Sudanese women in the second and third trimesters were recruited to the study during routine antenatal care visits in two major maternity hospitals in Khartoum state. They were screened for PND at 3 months postpartum using the EPDS. Test positive women were matched with test negative women according to nearest date of birth. A clinical psychologist verified their depression status using the MINI. Results The follow-up rate was 79%. At a cutoff point of ≥12, the 3 months prevalence of PND was 9.2%. The sensitivity and specificity of the EPDS were 89% and 82%, respectively. The EPDS and MINI showed a strong positive relationship (odds ratio =36). The positive predictive value and negative predictive value, using this study’s prevalence, were 33% and 98.7%, respectively. The receiver operator characteristic analysis showed an area under the curve of 0.89. The cut-off point ≥12 was the most acceptable point as it had the lowest number needed to diagnose (1.4) and a false-positive rate of 18%. Conclusion The EPDS is a valid tool for screening for PND on a Sudanese population. It was accepted, easily administered, and understood by postnatal women. Health care personnel, especially village midwives, should be trained on screening and referral of depressed women for clinical evaluation and management. Due to limited resources available in Sudan, shorter screening tests need to be validated in the future. PMID

  16. Critical appraisal of 3-monthly paliperidone depot injections in the treatment of schizophrenia

    PubMed Central

    Carpiniello, Bernardo; Pinna, Federica

    2016-01-01

    Aims Three-monthly injections of paliperidone palmitate (PP-3M) represent a new and recently introduced long-acting antipsychotic therapeutic option. This review focuses on available data relating to the efficacy and safety of PP-3M and its position in the current therapeutic scenario. Method An analysis of PubMed, Scopus, and ISI Web of Knowledge databases was conducted, and all available papers on PP-3M, including poster presentations, were selected and considered for the purpose of the present review. Findings: to date, three full papers have been published, the first, a Phase 1 randomized, open label study investigating the pharmacokinetics, safety, and tolerability of the drug; the second, a Phase 3 double blind study vs placebo focusing on efficacy and tolerability; and the last relating to the practical use of PP-3M. The five posters identified describe data reported in the above-cited papers. Overall, the pharmacokinetic findings obtained in these studies highlight the feasibility of administering PP-3M on a 3-monthly basis, subsequent to the administration of four 1-monthly injections of PP at doses 3.5 times higher than the stabilized dose of 1-monthly injections of PP (ie, 175, 300, 450, and 525 mgs). The published studies highlight a significantly longer time to relapse compared to placebo, and significantly better results compared to placebo for all secondary end-points (Positive and Negative Syndrome Scale, Clinical Global Impression-Severity Scale, Personal and Social Performance Scale scores), in addition to reasonably good safety and tolerability profiles. Conclusion PP-3M emerges as a potential candidate for use as a first-line long-acting agent in the maintenance treatment of patients with schizophrenia. Further studies should however be conducted to confirm this expectation. In view of its efficacy, tolerability, and safety, together with the longer timespan between injections, PP-3M currently represents one of the best available options, and

  17. A Low Baseline Glomerular Filtration Rate Predicts Poor Clinical Outcome at 3 Months after Acute Ischemic Stroke

    PubMed Central

    Kim, Hyung Jik; Kim, Jwa-Kyung; Oh, Mi Sun; Kim, Sung Gyun; Yu, Kyung-Ho

    2015-01-01

    Background and Purpose Chronic kidney disease (CKD) is an established risk factor for numerous cardiovascular diseases including stroke. The relationship between the baseline estimated glomerular filtration rate (eGFR) and clinical 3-month outcomes in patients with acute ischemic stroke were evaluated in this study. Methods This was a prospective cohort study involving a hospital-based stroke registry; 1373 patients with acute ischemic stroke were enrolled. Patients were divided into the following four groups according their eGFR (calculated using the CKD Epidemiology Collaboration equations): ≥60, 45-59, 30-44, and <30 mL/min/1.73 m2. The primary endpoint of poor functional outcome was defined as 3-month death or dependency (modified Rankin Scale score ≥3); secondary endpoints were neurological deterioration (increase in National Institutes of Health Stroke Severity score of ≥4 at discharge compared to baseline) during hospitalization and in-hospital mortality. Results The overall eGFR was 84.5±20.8 mL/min/1.73 m2 (mean±SD). The distribution of baseline renal impairment was as follows: 1,218, 82, 40, and 33 patients had eGFRs of ≥60, 45-59, 30-44, and <30 mL/min/1.73 m2, respectively. At 3 months after the stroke, 476 (34.7%) patients exhibited poor functional outcome. Furthermore, a poor functional outcome occurred more frequently with increasingly advanced stages of CKD (rates of 31.9%, 53.7%, 55.0%, and 63.6% for CKD stages 1/2, 3a, 3b, and 4/5, respectively; p<0.001). Multivariate analysis revealed that a baseline eGFR of <30 mL/min/1.73m2 increased the risk of a poor functional outcome by 2.37-fold (p=0.047). In addition, baseline renal dysfunction was closely associated with neurological deterioration during hospitalization and with in-hospital mortality. Conclusions A low baseline eGFR was strongly predictive of both poor functional outcome at 3 months after ischemic stroke and neurological deterioration/mortality during hospitalization. PMID

  18. Periodic Lateralized Epileptiform Discharges can Survive Anesthesia and Result in Asymmetric Drug-induced Burst Suppression

    PubMed Central

    Mader, Edward C.; Cannizzaro, Louis A.; Williams, Frank J.; Lalan, Saurabh; Olejniczak, Piotr W.

    2017-01-01

    Drug-induced burst suppression (DIBS) is bihemispheric and bisymmetric in adults and older children. However, asymmetric DIBS may occur if a pathological process is affecting one hemisphere only or both hemispheres disproportionately. The usual suspect is a destructive lesion; an irritative or epileptogenic lesion is usually not invoked to explain DIBS asymmetry. We report the case of a 66-year-old woman with new-onset seizures who was found to have a hemorrhagic cavernoma and periodic lateralized epileptiform discharges (PLEDs) in the right temporal region. After levetiracetam and before anesthetic antiepileptic drugs (AEDs) were administered, the electroencephalogram (EEG) showed continuous PLEDs over the right hemisphere with maximum voltage in the posterior temporal region. Focal electrographic seizures also occurred occasionally in the same location. Propofol resulted in bihemispheric, but not in bisymmetric, DIBS. Remnants or fragments of PLEDs that survived anesthesia increased the amplitude and complexity of the bursts in the right hemisphere leading to asymmetric DIBS. Phenytoin, lacosamide, ketamine, midazolam, and topiramate were administered at various times in the course of EEG monitoring, resulting in suppression of seizures but not of PLEDs. Ketamine and midazolam reduced the rate, amplitude, and complexity of PLEDs but only after producing substantial attenuation of all burst components. When all anesthetics were discontinued, the EEG reverted to the original preanesthesia pattern with continuous non-fragmented PLEDs. The fact that PLEDs can survive anesthesia and affect DIBS symmetry is a testament to the robustness of the neurodynamic processes underlying PLEDs. PMID:28286626

  19. Latitudinal variation of perturbation electric fields during magnetically disturbed periods - 1986 Sundial observations and model results

    NASA Technical Reports Server (NTRS)

    Fejer, B. G.; Spiro, R. W.; Wolf, R. A.; Foster, J. C.

    1990-01-01

    F-region incoherent scatter radar drift observations from Millstone Hill and Jicamarca, h-prime F observations from Huancayo, and high latitude ground-magnetometer measurements taken during the Sundial 1986 campaign are used to study the relationship between plasmaspheric electric field perturbations and high latitude currents during disturbed periods. The observations are in good agreement with numerical results from a Rice Covection Model run that involved a sharp increase in the polar cap potential drop followed by a subsequent decrease. The zonal disturbance electric field pattern is latitude independent, and the corresponding amplitudes change approximately as L exp n (where n is about 1.5). The meridional electric field patterns and amplitudes have larger latitudinal variations. The mid-, low, and equatorial electric fields from the Rice Convection Model are in good agreement with previous results from the semianalytic, Senior-Blanc (1987) model. Also discussed are three physical mechanisms (over-shielding, fossil winds, and magnetic reconfiguration) that contribute to the long lasting (1-2 h) equatorial zonal electric field perturbations associated with a sudden northward turning of the IMF. It is predicted that the penetration of high latitude electric fields to low latitudes should, in general, be closely related to the rate of motion of the shielding layer and the equatorward edge of the diffuse aurora.

  20. The origins of word learning: Brain responses of 3-month-olds indicate their rapid association of objects and words.

    PubMed

    Friedrich, Manuela; Friederici, Angela D

    2017-03-01

    The present study explored the origins of word learning in early infancy. Using event-related potentials (ERP) we monitored the brain activity of 3-month-old infants when they were repeatedly exposed to several initially novel words paired consistently with each the same initially novel objects or inconsistently with different objects. Our results provide strong evidence that these young infants extract statistic regularities in the distribution of the co-occurrences of objects and words extremely quickly. The data suggest that this ability is based on the rapid formation of associations between the neural representations of objects and words, but that the new associations are not retained in long-term memory until the next day. The type of brain response moreover indicates that, unlike in older infants, in 3-month-olds a semantic processing stage is not involved. Their ability to combine words with meaningful information is caused by a primary learning mechanism that enables the formation of proto-words and acts as a precursor for the acquisition of genuine words.

  1. Posttraumatic reactions among injured children and their caregivers 3 months after the terrorist attack in Beslan.

    PubMed

    Scrimin, Sara; Axia, Giovanna; Capello, Fabia; Moscardino, Ughetta; Steinberg, Alan M; Pynoos, Robert S

    2006-03-30

    This report describes symptoms of posttraumatic stress disorder (PTSD) among a group of Beslan's children (N=22) and their primary caregivers (N=20) 3 months after the children had been taken hostage in their school by a group of terrorists. Attention and memory were also measured. Children and their caretakers showed high levels of ongoing PTSD symptoms. Children also showed difficulties in sustaining attention and in short-term memory (digit span). These scores strongly indicate the need for appropriate interventions and ongoing monitoring of course of recovery.

  2. Solitary Myofibroma of the Bladder Trigone in a 3-Month-Old Patient: First Case Report

    PubMed Central

    Pensabene, Marco; Siracusa, Fortunato; Rodolico, Vito; Li Voti, Giuseppe; Zambaiti, Elisa; Cimador, Marcello

    2016-01-01

    Visceral solitary myofibromas are uncommon in childhood. We report a case of a solitary asymptomatic visceral myofibroma of the bladder trigone occurring in a 3-month-old boy. Once malignancies were ruled out by cystoscopy, radical excision was performed in order to avoid any potential impairment of bladder dynamic. Postoperative course was uneventful and patient was discharged on day 3 after surgery. After 36 months of follow-up, the patient is toilet-trained and remains well; bladder function is normal. PMID:27242942

  3. Osteofibrous dysplasia-like adamantinoma in a 3-month-old male infant: a case report.

    PubMed

    Buldu, Halil; Centel, Tuncay; Kırımlıoğlu, Hale; Dirik, Yalın

    2015-01-01

    We report a case of a very rarely seen osteofibrous dysplasia-like adamantinoma (OFDLA) of the lower leg in a 3-month-old male infant, making it the youngest case in the literature. OFDLA is typically regarded as a benign lesion; however, due to its convertibility into classical adamantinoma, it is recommended to evaluate it as a pre-malignant lesion. After OFDLA diagnosis with biopsy, our case underwent surgical resection and reconstruction with a large allograft. Patient experienced good outcomes and did not experience any local relapse in the 3-year follow-up.

  4. STS-40 orbital acceleration research experiment flight results during a typical sleep period

    NASA Technical Reports Server (NTRS)

    Blanchard, R. C.; Nicholson, J. Y.; Ritter, J. R.

    1992-01-01

    The Orbital Acceleration Research Experiment (OARE), an electrostatic accelerometer package with complete on-orbit calibration capabilities, was flown for the first time aboard the Space Shuttle on STS-40. This is also the first time an accelerometer package with nano-g sensitivity and a calibration facility has flown aboard the Space Shuttle. The instrument is designed to measure and record the Space Shuttle aerodynamic acceleration environment from the free molecule flow regime through the rarified flow transition into the hypersonic continuum regime. Because of its sensitivity, the OARE instrument defects aerodynamic behavior of the Space Shuttle while in low-earth orbit. A 2-hour orbital time period on day seven of the mission, when the crew was asleep and other spacecraft activities were at a minimum, was examined. During the flight, a 'trimmed-mean' filter was used to produce high quality, low frequency data which was successfully stored aboard the Space Shuttle in the OARE data storage system. Initial review of the data indicated that, although the expected precision was achieved, some equipment problems occurred resulting in uncertain accuracy. An acceleration model which includes aerodynamic, gravity-gradient, and rotational effects was constructed and compared with flight data. Examination of the model with the flight data shows the instrument to be sensitive to all major expected low frequency acceleration phenomena; however, some erratic instrument bias behavior persists in two axes. In these axes, the OARE data can be made to match a comprehensive atmospheric-aerodynamic model by making bias adjustments and slight linear corrections for drift. The other axis does not exhibit these difficulties and gives good agreement with the acceleration model.

  5. Recent improvement in lung cancer screening: a comparison of the results carried out in two different time periods.

    PubMed

    Kitajima, Takuji; Nishii, Kenji; Ueoka, Hiroshi; Shibayama, Takuo; Gemba, Kenichi; Kodani, Tsuyoshi; Kiura, Katsuyuki; Tabata, Masahiro; Hotta, Katsuyuki; Tanimoto, Mitsune; Sobue, Tomotaka

    2006-06-01

    To evaluate recent improvements in lung cancer screening, we compared the results of recently conducted lung cancer screening with those of a previous screening. This study compared the survival of lung cancer patients detected by lung cancer screening conducted between 1976 and 1984 (early period) with that conducted between 1989 and 1997 (late period). Two hundred seventy-six patients with lung cancer were detected in the early period and 541 patients with lung cancer were detected in the late period. The median survival time (late : 49.8 vs. early : 27.8 months) and the 5-year survival rate (late : 47.8 vs. early : 34.8%) of the patients with lung cancer detected in the late period were significantly better than those in the early period (p = 0.0054). Among patients undergoing resection, the proportion of pathological stage I patients in the late period was significantly higher than that in the early period (late : 60.8 vs. early : 54.9%, p = 0.005). Multivariate analysis showed that the screening time period was a significant prognostic factor (hazard ratio = 0.685, 95% confidence interval : 0.563-0.832, p = 0.0002). These results were consistent with the findings of case-control studies of lung cancer screening programs in the late period recently conducted in Japan, which also showed a greater efficacy for screening than for previous case-control studies in the early period.

  6. Neutrophil-To-Lymphocyte Ratio Predicts 3-Month Outcome of Acute Ischemic Stroke.

    PubMed

    Qun, Sen; Tang, Yan; Sun, Jing; Liu, Zhaoxia; Wu, Juncang; Zhang, Ji; Guo, Jidong; Xu, Zhiqiang; Zhang, Dan; Chen, Zhengxu; Hu, Fuyong; Xu, Xingshun; Ge, Wei

    2017-04-01

    Increasing evidences have demonstrated that inflammation is involved in the mechanisms of acute ischemic stroke (AIS). As an important and easy-to-measure inflammatory marker, neutrophil-to-lymphocyte ratio (NLR) shows a high association with mortality in patients with stroke in recent studies. In this study, we evaluated the prognostic role of NLR in patients with AIS. One hundred forty-three patients with AIS were enrolled. Clinical data were collected and the NLR was calculated from the admission blood work. The patients were followed up for 3 months after stroke onset. The occurrence of death and the major disability at 3 months after onset were end points in this study. Modified Rankin Scale score ≥3 was considered as poor outcome. In this study, 75 patients (52%) had poor outcome. We used binary logistic regression model to evaluate risk factor for poor outcome of AIS and found that the NLR was independently associated with the poor outcome of 3 months (P < 0.001). The optimal cutoff value for NLR as a predictor for 3-month outcome was 2.995. Therefore, in our study, high NLRs inversely predicted 3-month outcome in patients with AIS.

  7. Severe Kawasaki disease in a 3-month-old patient: a case report

    PubMed Central

    2013-01-01

    Background Kawasaki disease is a multi-system vasculitis which usually occurs in children under 5 years of age. In infants under three months of age, it is very rare and usually associated with a high incidence of incomplete or atypical forms, often unresponsive to treatment. This condition increases the risk of cardiovascular complications such as coronary artery aneurysms. Case presentation We describe a 3-month-old infant who developed early and severe aneurysms in three coronary arteries despite a timely administration of intravenous immunoglobulins, followed by three days of intravenous methylprednisolone. Conclusion This case report underlines that the development of coronary artery aneurysm correlates with a delayed diagnosis and treatment, incomplete or atypical forms of the disease, and additionally the severity of clinical presentation, especially in cases of very young infants below 3 months of age. Our case is notable because of the very young age of the patient, the severity of clinical presentation with an early development of coronary artery aneurysms and the unresponsiveness to the therapy. PMID:24294914

  8. Complete sternal cleft — A rare congenital malformation and its repair in a 3-month-old boy: A case report

    PubMed Central

    Kothari, Paras; Gupta, Abhaya; Patil, Prashant S.; Kekre, Geeta; Kamble, Ravi; Dikshit, Kiran Vishesh

    2016-01-01

    Complete midline sternal cleft is a rare congenital anomaly resulting from failed midline ventral fusion of the sternal bars. Very few cases of complete sternal cleft have been described in literature. We present a case of complete sternal cleft in a 3-month-old child. The patient underwent primary closure of the defect using stainless steel wires. PMID:27046980

  9. Cross-Race Preferences for Same-Race Faces Extend beyond the African versus Caucasian Contrast in 3-Month-Old Infants

    ERIC Educational Resources Information Center

    Kelly, David J.; Liu, Shaoying; Ge, Liezhong; Quinn, Paul C.; Slater, Alan M.; Lee, Kang; Liu, Qinyao; Pascalis, Olivier

    2007-01-01

    A visual preference procedure was used to examine preferences among faces of different ethnicities (African, Asian, Caucasian, and Middle Eastern) in Chinese 3-month-old infants exposed only to Chinese faces. The infants demonstrated a preference for faces from their own ethnic group. Alongside previous results showing that Caucasian infants…

  10. Quasi-periodic Pulsations in Solar and Stellar Flares: An Overview of Recent Results (Invited Review)

    NASA Astrophysics Data System (ADS)

    Van Doorsselaere, Tom; Kupriyanova, Elena G.; Yuan, Ding

    2016-11-01

    Quasi-periodic pulsations (or QPPs) are periodic intensity variations in the flare emission that occur across all wavelength bands. In this article, we review the observational and modelling achievements since the previous review on this topic by Nakariakov and Melnikov ( Space Sci. Rev. 149, 119, 2009). In recent years, it has become clear that QPPs are an inherent feature of solar flares because almost all flares exhibit QPPs. Moreover, it is now firmly established that QPPs often show multiple periods. We also review possible mechanisms for generating QPPs. Up to now, it has not been possible to conclusively identify the triggering mechanism or cause of QPPs. The lack of this identification currently hampers possible seismological inferences of flare plasma parameters. QPPs in stellar flares have been detected for a long time, and the high-quality data of the Kepler mission allows studying the QPP more systematically. However, it has not been conclusively shown whether the timescales of stellar QPPs are different or the same as those in solar flares.

  11. Intestinal calcium-binding protein 3 months after massive small bowel resection in the piglet.

    PubMed

    Margolis, A; Ricour, C; Harouchi, A; Guyot, M; Laouari, D; Balsan, S

    1977-12-01

    Changes in intestinal calcium-binding protein and calcium binding activity were studied at resection and 3 months after 90% small bowel resection in piglets and one adult pig. A calcium-binding protein (MW congruent to 11.000) with calcium-dependent eletrophoretic mobility was partially purified from mucosal extract of proximal jejunum, mid-gut, and ileum. The concentration of calcium-binding protein and the calcium-binding activity of the intact animals were found highest in the proximal jejunal segment, lowest in the ileal segment. After resection in the four surviving animals out of nine, a significant increase in calcium-binding activity was observed in the proximal jejunum and in the distal ileal segment. The change in calcium-binding activity was much more marked in the ileum than the jejunum. These data demonstrate that pig intestinal mucosa possesses an adaptive capacity to increase the synthesis of calcium-binding protein after massive small bowel resection.

  12. Holoprosencephaly and diabetes insipidus in a 3-month-old infant.

    PubMed

    Kourti, Maria; Pavlou, Evaggelos; Rousso, Israel; Economou, Ippolyti; Athanassiadou, Fani

    2008-01-01

    Holoprosencephaly is a developmental defect caused by incomplete cleavage of the embryonic forebrain structures during early embryogenesis. We describe a 3-month-old boy with median cleft palate, surgically reconstructed cleft lip, hypotelorism with a flat nose, cryptorchidism, clubfoot, and microcephaly. During the laboratory investigation, his blood sodium level was 154 mmol/L and urine specific gravity was 1.007. Serum osmolarity was 317 mOsm/kg and urine osmolarity was 268 mOsm/kg. Given these findings and the clinical response to vasopressin, diagnosis of central diabetes insipidus was made. Magnetic resonance imaging revealed semilobar holoprosencephaly. The patient responded very well to vasopressin treatment with restoration of serum electrolytes, which remained within normal limits on follow-up. In case of midline facial defects accompanied by hypotelorism with or without developmental delay, the brain should be imaged to confirm its morphology and investigations should be directed by a high index of suspicion of associated endocrinologic dysfunctions.

  13. Pharmacokinetics and Safety of Caspofungin in Neonates and Infants Less than 3 Months of Age▿

    PubMed Central

    Sáez-Llorens, Xavier; Macias, Mercedes; Maiya, Padmanabha; Pineros, Juan; Jafri, Hasan S.; Chatterjee, Archana; Ruiz, Gloria; Raghavan, Janaki; Bradshaw, Susan K.; Kartsonis, Nicholas A.; Sun, Peng; Strohmaier, Kim M.; Fallon, Marissa; Bi, Sheng; Stone, Julie A.; Chow, Joseph W.

    2009-01-01

    Candida infections represent a major threat in neonatal intensive care units. This is the first prospective study to obtain caspofungin plasma levels and safety data for neonates and very young infants. Patients of <3 months of age receiving intravenous amphotericin B for documented or highly suspected candidiasis were enrolled in a single-dose (n = 6) or subsequent multiple-dose (n = 12) panel; all received caspofungin at 25 mg/m2 once daily as a 1-hour infusion. Caspofungin plasma levels were measured by high-performance liquid chromatography and compared to historical data from adults. Patient chronological ages ranged from 1 to 11 weeks, and weights ranged from 0.68 to 3.8 kg. Gestational ages ranged from 24 to 41 weeks. Geometric mean (GM) peak (C1 h) and trough (C24 h) caspofungin levels were 8.2 and 1.8 μg/ml, respectively, on day 1, and 11.1 and 2.4 μg/ml, respectively, on day 4. GM ratios for C1 h and C24 h for neonates/infants relative to adults receiving caspofungin at 50 mg/day were 1.07 and 1.36, respectively, on day 1, and 1.18 and 1.21, respectively, on day 4. Clinical and laboratory adverse events occurred in 17 (94%) and 8 (44%) patients, respectively. Five patients (28%) had serious adverse events, none of which were considered drug related. Caspofungin at 25 mg/m2 once daily was well tolerated in this group of neonates/infants of <3 months of age and appears to provide relatively similar plasma exposure to that obtained in adults receiving 50 mg/day. However, the small number of patients studied precludes any definitive recommendations about caspofungin dosing for this group comprising a broad range of ages and weights. PMID:19075070

  14. A 3-month intervention of Dance Dance Revolution improves interference control in elderly females: a preliminary investigation.

    PubMed

    Chuang, Lan-Ya; Hung, Hsiao-Yun; Huang, Chung-Ju; Chang, Yu-Kai; Hung, Tsung-Min

    2015-04-01

    Exercise regimens suitable to the elderly remain under investigated; therefore, this study examined the effects of Dance Dance Revolution (DDR) on cognitive control in elderly females. Twenty-six healthy elderly females leading a sedentary lifestyle were assigned to a DDR, brisk walking, or control group. Participants in the DDR and brisk walking groups engaged in moderate physical exercise three times per week for 3 months, whereas the control group maintained a sedentary lifestyle. Each participant performed a flanker task before and after the intervention. The results revealed that both DDR and brisk walking shortened reaction time, N2 latency, and P3 latency relative to those of the control group. These findings suggest that DDR intervention is as effective as that of brisk walking in improving inhibitory control for elderly people. Therefore, DDR can be used as a viable alternative exercise to enhance cognitive function for the elderly and motivate individuals who are less willing to be active.

  15. Clinical efficacy of an optimized stannous fluoride dentifrice, Part 5: A 3-month study of extrinsic tooth staining, northeast USA.

    PubMed

    Bosma, M L; Besho, R W; Walley, D; Mankodi, S; Petrone, M E; Chaknis, P; DeVizio, W; Volpe, A R; Proskin, H M

    1997-01-01

    The objective of this 3-month, double-blind clinical study was to investigate the level of tooth staining associated with the use of Colgate Optimized Stannous Fluoride (COSF) dentifrice compared to the tooth staining associated with two commercially available dentifrices. The results of this clinical study support the conclusion that the intensity and extent of extrinsic tooth stain associated with the use of the COSF dentifrice are significantly lower than that associated with Crest Gum Care Toothpaste. Further, this study provided no indication that the use of the COSF dentifrice is associated with a greater level of stain than that associated with the use of Crest Regular Toothpaste, a standard 0.243% sodium fluoride/silica dentifrice.

  16. Experimental results of antigliadin antibodies detection using long period fiber grating

    NASA Astrophysics Data System (ADS)

    Corres, J. M.; Matias, I. R.; Goicoechea, J.; Arregui, F. J.; Viegas, D.; Araújo, F. M.; Santos, J. L.

    2008-04-01

    In this work a new nano-biofilm is proposed for the detection of celiac disease (CD). A long-period fiber grating (LPFG) is used as a transducer and the surface of the fiber is coated with a precursor layer of SiO2-nanospheres using the electrostatic self-assembly technique (ESA). This layer has been designed in order to create a substrate of high porosity where the gliadins could be deposited. Under the presence of specific antibodies antigliadin antibodies (AGA) the refractive index of the overlay changes giving a detectable shift in the resonance wavelength of the LPFG. Concentrations as low as 5 ppm were detected.

  17. Comparative in vitro release and clinical pharmacokinetics of leuprolide from Luphere 3M Depot, a 3-month release formulation of leuprolide acetate.

    PubMed

    Park, Sunghoon; Kim, Dong-Hwan; Kim, Yoon; Park, Jeong Hwa; Lee, MinSeok; Song, Im-Sook; Shim, Chang-Koo

    2017-03-01

    A 3-month depot formulation of leuprolide acetate (Luphere 3M Depot) with a mean microsphere diameter of 22.3 μm was prepared aseptically by spray-drying glacial acetic acid solution of the drug and polylactic acid, and lyophilization in a d-mannitol solution. The encapsulation efficiency and loading content of the drug in the Luphere 3M Depot were 94.7% and 9.92% (w/w), respectively. The in vitro release of leuprolide from the depot was substantially delayed and the release profile was similar to that of Lucrin Depot (Abbott Korea, Korea). The safety and pharmacokinetics of leuprolide were investigated over a period of 42 days in 20 prostate cancer patients following a subcutaneous injection of Luphere 3M or Lucrin Depot suspensions (leuprolide acetate dose of 11.25 mg) in a multi-center, randomized, single dose, parallel study. Both formulations were well tolerated by the patients and no serious adverse effects were observed during and after the study. No significant differences were observed in the maximum serum concentration (Cmax) and area under the curve (AUClast) of leuprolide between the two formulations. The results suggest comparable safety and efficacy profiles of Luphere 3M Depot and Lucrin Depot in clinical situations.

  18. Enhanced cued fear memory following post-training whole body irradiation of 3-month-old mice.

    PubMed

    Olsen, Reid H J; Weber, Sydney J; Akinyeke, Tunde; Raber, Jacob

    2017-02-15

    Typically, in studies designed to assess effects of irradiation on cognitive performance the animals are trained and tested for cognitive function following irradiation. Little is known about post-training effects of irradiation on cognitive performance. In the current study, 3-month-old male mice were irradiated with X-rays 24h following training in a fear conditioning paradigm and cognitively tested starting two weeks later. Average motion during the extinction trials, measures of anxiety in the elevated zero maze, and body weight changes over the course of the study were assessed as well. Exposure to whole body irradiation 24h following training in a fear conditioning resulted in greater freezing levels 2 weeks after training. In addition, motion during both contextual and cued extinction trials was lower in irradiated than sham-irradiated mice. In mice trained for cued fear conditioning, activity levels in the elevated zero maze 12days after sham-irradiation or irradiation were also lower in irradiated than sham-irradiated mice. Finally, the trajectory of body weight changes was affected by irradiation, with lower body weights in irradiated than sham-irradiated mice, with the most profound effect 7days after training. These effects were associated with reduced c-Myc protein levels in the amygdala of the irradiated mice. These data indicate that whole body X ray irradiation of mice at 3 months of age causes persistent alterations in the fear response and activity levels in a novel environment, while the effects on body weight seem more transient.

  19. Early Prediction of 3-month Survival of Patients in Refractory Cardiogenic Shock and Cardiac Arrest on Extracorporeal Life Support

    PubMed Central

    Delmas, Clément; Conil, Jean-Marie; Sztajnic, Simon; Georges, Bernard; Biendel, Caroline; Dambrin, Camille; Galinier, Michel; Minville, Vincent; Fourcade, Olivier; Silva, Stein; Marcheix, Bertrand

    2017-01-01

    Background: Extracorporeal life support (ECLS) holds the promise of significant improvement of the survival of patient in refractory cardiogenic shock (CS) or cardiac arrest (CA). Nevertheless, it remains to be shown to which extent these highly invasive supportive techniques could improve long-term patient's outcome. Methods: The outcomes of 82 adult ECLS patients at our institution between January 2012 and December 2013 were retrospectively analyzed. Results: Patients were essentially men (64.7%) and are 54 years old. Preexisting ischemic (53.7%) and dilated cardiomyopathy (14.6%) were frequent. ECLS indications were shared equally between CA and CS. ECLS-specific adverse effects as hemorrhage (30%) and infection (50%) were frequent. ECLS was effective for 43 patients (54%) with recovery for 35 (43%), 5 (6%) heart transplant, and 3 (4%) left ventricular assist device support. Mortality rate at 30 days was 59.8%, but long-term and 3-month survival rates were similar of 31.7%. Initial plasma lactate levels >5.3 mmol/L and glomerular filtration rate <43 ml/min/1.73 m2 were significantly associated with 3-month mortality (risk ratio [RR] 2.58 [1.21–5.48]; P = 0.014; RR 2.10 [1.1–4]; P = 0.024, respectively). Long-term follow-up had shown patients paucisymptomatic (64% New York Heart Association 1–2) and autonomic (activities of daily living [ADL] score 6 ± 1.5). Conclusion: In case of refractory CA or CS, lactates and renal function at ECLS initiation could serve as outcome predictor for risk stratification and ECLS indication.

  20. STS-40 orbital acceleration research experiment flight results during a typical sleep period

    NASA Technical Reports Server (NTRS)

    Blanchard, Robert C.; Nicholson, John Y.; Ritter, James R.

    1992-01-01

    The Orbital Acceleration Research Experiment (OARE), an electrostatic accelerometer package with complete on-orbit calibration capabilities was flown aboard Shuttle on STS-40. The instrument is designed to measure and record the Shuttle aerodynamic acceleration environment from the free molecule flow regime through the rarefied flow transition into the hypersonic continuum regime. Because of its sensitivity, the OARE instrument detects aerodynamic behavior of the Shuttle while in low-earth orbit. A 2-h orbital time period on day seven of the mission, when the crew was asleep and other spacecraft activities were at a minimum, was examined. Examination of the model with the flight data shows the instrument to be sensitive to all major expected low-frequency acceleration phenomena; however, some erratic instrument bias behavior persists in two axes. In these axes, the OARE data can be made to match a comprehensive atmospheric-aerodynamic model by making bias adjustments and slight liner corrections for drift.

  1. Acute and 3-month effects of microcrystalline hydroxyapatite, calcium citrate and calcium carbonate on serum calcium and markers of bone turnover: a randomised controlled trial in postmenopausal women.

    PubMed

    Bristow, Sarah M; Gamble, Greg D; Stewart, Angela; Horne, Lauren; House, Meaghan E; Aati, Opetaia; Mihov, Borislav; Horne, Anne M; Reid, Ian R

    2014-11-28

    Ca supplements are used for bone health; however, they have been associated with increased cardiovascular risk, which may relate to their acute effects on serum Ca concentrations. Microcrystalline hydroxyapatite (MCH) could affect serum Ca concentrations less than conventional Ca supplements, but its effects on bone turnover are unclear. In the present study, we compared the acute and 3-month effects of MCH with conventional Ca supplements on concentrations of serum Ca, phosphate, parathyroid hormone and bone turnover markers. We randomised 100 women (mean age 71 years) to 1 g/d of Ca as citrate or carbonate (citrate-carbonate), one of two MCH preparations, or a placebo. Blood was sampled for 8 h after the first dose, and after 3 months of daily supplementation. To determine whether the acute effects changed over time, eight participants assigned to the citrate dose repeated 8 h of blood sampling at 3 months. There were no differences between the citrate and carbonate groups, or between the two MCH groups, so their results were pooled. The citrate-carbonate dose increased ionised and total Ca concentrations for up to 8 h, and this was not diminished after 3 months. MCH increased ionised Ca concentrations less than the citrate-carbonate dose; however, it raised the concentrations of phosphate and the Ca-phosphate product. The citrate-carbonate and MCH doses produced comparable decreases in bone resorption (measured as serum C-telopeptide (CTX)) over 8 h and bone turnover (CTX and procollagen type-I N-terminal propeptide) at 3 months. These findings suggest that Ca preparations, in general, produce repeated sustained increases in serum Ca concentrations after ingestion of each dose and that Ca supplements with smaller effects on serum Ca concentrations may have equivalent efficacy in suppressing bone turnover.

  2. Intra-Arterial Chemotherapy as Primary Therapy for Retinoblastoma in Infants Less than 3 Months of Age: A Series of 10 Case-Studies

    PubMed Central

    Xia, Jiejun; Liu, Zhenyin; Jiang, Hua; Shen, Gang; Li, Haibo; Jiang, Yizhou; Zhang, Jing

    2016-01-01

    Purpose Retinoblastoma is the most common primary malignant intra-ocular tumor in children. Although intra-arterial chemotherapy (IAC) by selectively infusing chemotherapy through the ophthalmic artery has become an essential technique in the treatment of advanced intra-ocular retinoblastoma in children, the outcome of IAC as primary therapy for infants less than 3 months of age remains unknown. In this retrospective study, we reviewed the outcome of IAC as primary therapy for retinoblastoma in infants less than 3 months of age. Methods We retrospectively reviewed ten retinoblastoma patients attending our center from January 2009 to September 2015 and beginning primary IAC before the age of 3 months. The patient characteristics, overall outcomes and therapy-related complications were assessed. Results The mean patient age at the first IAC treatment was 10.4 weeks (range 4.9–12.9 weeks). These eyes were classified according to the International Classification of Retinoblastoma (ICRB) as group A (n = 0), B (n = 2), C (n = 0), D (n = 9), or E (n = 2). A total of 28 catheterizations were performed, and the procedure was stopped in one patient because of internal carotid artery spasm. Each eye received a mean of 2.6 cycles of IAC (range 2–4 cycles). After IAC with a mean follow-up of 28.3 months (range 9–65 months), tumor regression was observed in 12 of 13 eyes. One eye was enucleated due to tumor progression. All patients are alive and no patient has developed metastatic disease or other malignancies. Conclusions Our experience suggests IAC as primary therapy is a feasible and promising treatment for retinoblastoma in infants less than 3 months of age. PMID:27504917

  3. Contingency Learning and Reactivity in Preterm and Full-Term Infants at 3 Months

    PubMed Central

    Haley, David W.; Grunau, Ruth E.; Oberlander, Tim F.; Weinberg, Joanne

    2010-01-01

    Learning difficulties in preterm infants are thought to reflect impairment in arousal regulation. We examined relationships among gestational age, learning speed, and behavioral and physiological reactivity in 55 preterm and 49 full-term infants during baseline, contingency, and nonreinforcement phases of a conjugate mobile paradigm at 3 months corrected age. For all infants, negative affect, looking duration, and heart rate levels increased during contingency and nonreinforcement phases, whereas respiratory sinus arrhythmia (RSA, an index of parasympathetic activity) decreased and cortisol did not change. Learners showed greater RSA suppression and less negative affect than nonlearners. This pattern was particularly evident in the preterm group. Overall, preterm infants showed less learning, spent less time looking at the mobile, and had lower cortisol levels than full-term infants. Preterm infants also showed greater heart rate responses to contingency and dampened heart rate responses to nonreinforcement compared to full-term infants. Findings underscore differences in basal and reactivity measures in preterm compared to full-term infants and suggest that the capacity to regulate parasympathetic activity during a challenge enhances learning in preterm infants. PMID:20717491

  4. Ecthyma gangrenosum in a 3-month-old, previously healthy infant

    PubMed Central

    Zhang, Xiao-ting; Jin, Wan-wan; Ma, Xin-hua; Yu, Hai-feng; Tang, Xu-hua

    2017-01-01

    Abstract Rationale: Ecthyma gangrenosum (EG) is an aggressive cutaneous disease caused by local or systemic infection with Pseudomonas aeruginosa. EG is characterized by cutaneous manifestations ranging from nodule and papule, to necrotic ulceration with surrounding erythema, especially with black eschar or central crust. EG presents with characteristic skin lesions which is important to establish diagnosis of sepsis caused by P aeruginosa, a serious condition that can be treated efficiently if diagnosed early. Patient concerns: A 3-month-old female infant was presented with characteristic skin lesions of EG and developed sepsis 3 days later. Diagnoses: Ecthyma gangrenosum and sepsis caused by Pseudomonas aeruginosa. Interventions: Meropenem was used in combination with ceftazidime at first and excision of necrotic skin lesions was performed later. Outcomes: Cure. Lessons: Early recognition of EG plays an important role in providing appropriate empiric antibiotic treatment at early stage of sepsis, and improves the prognosis. Surgical excision may be helpful if no improvement was achieved via antibiotic treatment. PMID:28272221

  5. Results of magnetic measurements of ELF fields in Tomsk for the period 2013-2014

    NASA Astrophysics Data System (ADS)

    Kolmakov, A. A.; Kolesnik, S. A.; Nedosekov, D. A.

    2015-11-01

    The paper describes a method of magnetic measurements of natural electromagnetic fields ELF range. The results of the analysis of the frequency characteristics of fashion Schumann resonances in a suburban area in the seasonally-daily cycle of observations.

  6. [Influenza surveillance in five consecutive seasons during post pandemic period: results from National Influenza Center, Turkey].

    PubMed

    Altaş, Ayşe Başak; Bayrakdar, Fatma; Korukluoğlu, Gülay

    2016-07-01

    Influenza surveillance provides data about the characteristics of influenza activity, types, sub-types and antigenic properties of the influenza viruses in circulation in a region. Surveillance also provides for the preparation against potential influenza pandemics with the identification of the genetic properties of viruses and the mutant strains that could pose a threat. In this study, data in the scope of national influenza surveillance carried out by National Influenza Center, Turkey for five consecutive influenza seasons between 2010-2015, following the A(H1N1)pdm09 virus pandemic, have been presented and evaluated. A total of 15.149 respiratory samples, including 8.894 sentinel and 6.255 non-sentinel specimens, during 2010-2015 influenza seasons, within the periods between September and May, were evaluated in our center. All samples were tested using real-time reverse transcriptase PCR (rRT-PCR) for the presence of influenza virus types and subtypes. Within the sentinel influenza surveillance, the samples that were detected negative for influenza viruses, have also been tested for the other respiratory viruses (respiratory syncytial virus, rhinoviruses, paramyxoviruses, coronaviruses) using the same technique. Further analysis, including virus isolation by cell culture inoculation and antigenic characterization by hemagglutination inhibiton test were performed for the samples found positive for influenza A and B viruses. Selected representative virus isolates have been sent to WHO reference laboratory for the sequence analysis. In the study, influenza virus positivity rates detected for all of the samples (sentinel+non-sentinel) were as follows; 34% (779/2316) in 2010-11 season; 25% (388/1554) in 2011-12; 20% (696/3541) in 2012-13; 23% (615/2678) in 2013-14; and 26% (1332/5060) in 2014-15. When all the samples were considered for influenza A and B viruses, the positivity rates for the seasons of 2010-11; 2011-12; 2012-13; 2013-14; 2014-15 were determined as

  7. Amphetamines and cannabinoids testing in hair: Evaluation of results from a two-year period.

    PubMed

    Burgueño, María José; Alonso, Amaya; Sánchez, Sergio

    2016-08-01

    This paper presents an overview of a set of amphetamines and cannabinoids tests performed on head hair samples from the Medico-Legal sector at the Madrid Department of the Spanish National Institute of Toxicology and Forensic Sciences during the years 2013 and 2014. The hair samples were tested for five stimulant phenylalkylamine derivatives -amphetamine (AP), methamphetamine (MA), 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxy-amphetamine (MDA), and 3,4-methylenedioxy-N-ethylamphetamine (MDEA)- and/or two cannabinoids-Δ(9)-tetrahydrocannabinol (THC) and cannabinol (CBN)- by gas chromatography equipped with mass spectrometry detection in selected-ion monitoring mode, applying a method accredited to ISO/IEC 17025 standards. The test results were interpreted according to the confirmation cut-offs proposed by the Society of Hair Testing (SoHT) to identify chronic drug use. The ratios of positive results were studied in relation to gender, age, hair colour, dyeing and length of the tested samples to assess the independence from these variables or the association with them. Low, medium and high ranges of concentration were also estimated for each drug. 21.94% of the 2954 hair samples tested for phenylalkylamine derivatives were positive for one or more substances. 16.38% of the samples were positive for AP, 12.09% for MDMA and only 0.44% for MA. 6.60% of the tested samples were positive for AP/MDMA combination. A total of 3178 samples were tested for cannabinoids, resulting in 53.40% positive for THC and CBN. Simultaneous tests for phenylalkylamine derivatives and cannabinoids were performed in 2931 of the samples; 14.94% of them were positive for THC, CBN, and one or more amphetamines. According to the results from the statistical analysis, the use of THC and MDMA vary with age and gender among the Medico-Legal sector in an extended area of Spain, while the use of AP appears to be independent of these variables. On the other hand, the results of THC in

  8. [Cost of illness in Parkinson disease. A retrospective 3-month analysis of direct costs].

    PubMed

    Dodel, R C; Singer, M; Köhne-Volland, R; Selzer, R; Scholz, W; Rathay, B; Oertel, W H

    1997-12-01

    Parkinson's disease (PD) causes significant expense for the national health care system due to its chronic progressive course, the duration of the disease, the high prevalence and the devastating prognosis. In Germany more than DM 320 million are spent for drugs to alleviate parkinsonian symptoms. The aim of this study was to calculate the economic burden of PD by assessing direct medical costs. Forty patients suffering from idiopathic PD were interviewed at an office of neurological specialists and at an outpatient movement disorder clinic about their use of health care resources 3 months prior to the study. The total annual costs reported were DM 14,500, consisting of DM 6500 for drug therapy and DM 8000 for other medical services, including hospital inpatient care (DM 5600), outpatient care (DM 700), medical sundries (DM 1100) and physiotherapy (DM 600). The costs were positively correlated to the extent of the disease (Hoehn and Yahr stage; HY) and the occurrence of motor fluctuations/dyskinesias. We found that both drug-therapy expenses and total medical costs doubled from HYI to HYIV. The rarely employed s.c. therapy with apomorphine additionally increased the costs of drug therapy in HYV. The occurrence of fluctuations/ dyskinesias also increased medical expenses by approximately a factor of two. Indirect burden due to increased days off of work, unemployment and earlier retirement are also significant in Parkinson's disease. This study includes that a treatment which could prevent or retard disease progression as well as a treatment that delays or reduces motor complications would not only ameliorate the situation of patients suffering from PD, but would also lead to significant reductions in cost for the national health care system.

  9. Differential changes in self-reported aspects of interoceptive awareness through 3 months of contemplative training

    PubMed Central

    Bornemann, Boris; Herbert, Beate M.; Mehling, Wolf E.; Singer, Tania

    2015-01-01

    Interoceptive body awareness (IA) is crucial for psychological well-being and plays an important role in many contemplative traditions. However, until recently, standardized self-report measures of IA were scarce, not comprehensive, and the effects of interoceptive training on such measures were largely unknown. The Multidimensional Assessment of Interoceptive Awareness (MAIA) questionnaire measures IA with eight different scales. In the current study, we investigated whether and how these different aspects of IA are influenced by a 3-months contemplative intervention in the context of the ReSource project, in which 148 subjects engaged in daily practices of “Body Scan” and “Breath Meditation.” We developed a German version of the MAIA and tested it in a large and diverse sample (n = 1,076). Internal consistencies were similar to the English version (0.56–0.89), retest reliability was high (rs: 0.66–0.79), and the MAIA showed good convergent and discriminant validity. Importantly, interoceptive training improved five out of eight aspects of IA, compared to a retest control group. Participants with low IA scores at baseline showed the biggest changes. Whereas practice duration only weakly predicted individual differences in change, self-reported liking of the practices and degree of integration into daily life predicted changes on most scales. Interestingly, the magnitude of observed changes varied across scales. The strongest changes were observed for the regulatory aspects of IA, that is, how the body is used for self-regulation in daily life. No significant changes were observed for the Noticing aspect (becoming aware of bodily changes), which is the aspect that is predominantly assessed in other IA measures. This differential pattern underscores the importance to assess IA multi-dimensionally, particularly when interested in enhancement of IA through contemplative practice or other mind–body interventions. PMID:25610410

  10. Prevalence and risk factors of posttraumatic stress disorder among teachers 3 months after the Lushan earthquake

    PubMed Central

    Zhang, Jun; Zhang, Ye; Du, Changhui; Zhu, Shenyue; Huang, Yalin; Tian, Yulian; Chen, Decao; Li, Haimin; Gong, Yao; Zhang, Mengmeng; Gu, Bo

    2016-01-01

    Abstract Teachers and students often suffer from the same disaster. The prevalence of PTSD in students has been given great attention. However, in acting as mentors to students and their families, teachers are more likely to have vicarious and indirect exposure via hearing stories of their aftermath and witnessing the consequences of traumatic events. There are limited data pertaining to the prevalence of PTSD and its risk factors among teachers. A total of 316 teachers from 21 primary and secondary schools in Baoxing County were administered a project-developed questionnaire which included the items regarding demographic characteristics, earthquake-related experiences, somatic discomforts, emotional reactions, support status, and everyday functioning 2 weeks after the Lushan earthquake, and they finished a 1-to-1 telephone interview for addressing the PTSD criteria of the Mini International Neuropsychiatric Interview (MINI) 3 months after the earthquake. The prevalence of PTSD was 24.4% among teachers. Somatic discomforts (odds ratio [OR] 1.89, 95% confidence interval [CI] 1.06–3.37) were positive risk factors of PTSD. Perceived social support (OR 0.30, 95% CI 0.14–0.62) and being able to calm down (OR 0.25, 95% CI 0.09–0.75) in teaching were negative risk factors. PTSD is commonly seen among teachers after an earthquake, and risk factors of PTSD were identified. These findings may help those providing psychological health programs to find the teachers who are at high risk of PTSD in schools after an earthquake in China. PMID:27442675

  11. Design and Experimental Results for the S825 Airfoil; Period of Performance: 1998-1999

    SciTech Connect

    Somers, D. M.

    2005-01-01

    A 17%-thick, natural-laminar-flow airfoil, the S825, for the 75% blade radial station of 20- to 40-meter, variable-speed and variable-pitch (toward feather), horizontal-axis wind turbines has been designed and analyzed theoretically and verified experimentally in the NASA Langley Low-Turbulence Pressure Tunnel. The two primary objectives of high maximum lift, relatively insensitive to roughness and low-profile drag have been achieved. The airfoil exhibits a rapid, trailing-edge stall, which does not meet the design goal of a docile stall. The constraints on the pitching moment and the airfoil thickness have been satisfied. Comparisons of the theoretical and experimental results generally show good agreement.

  12. Long-term quasi-periodicity of 4U 1636-536 resulting from accretion disc instability

    NASA Astrophysics Data System (ADS)

    Wisniewicz, Mateusz; Zdziarski, Andrzej; Janiuk, Agnieszka; Rosinska, Dorota; Slowikowska, Agnieszka

    2016-07-01

    We present the results of a study of the low-mass X-ray binary 4U 1636-536. We have performed temporal analysis of all available RXTE/ASM, RXTE/PCA, Swift/BAT and MAXI data. We have confirmed the previously discovered quasi-periodicity of ˜45 d present during ˜2004, however we found it continued to 2006. At other epochs, the quasi-periodicity is only transient, and the quasi-period, if present, drifts. We have then applied a time-dependent accretion disc model to the interval with the significant X-ray quasi-periodicity. For our best model, the period and the amplitude of the theoretical light curve agree well with that observed. The modelled quasi-periodicity is due to the hydrogen thermal-ionization instability occurring in outer regions of the accretion disc. The model parameters are the average mass accretion rate (estimated from the light curves), and the accretion disc viscosity parameters, α_{cold} and α_{hot}, for the hot and cold phases, respectively. Our best model gives relatively low values of α_{cold} and α_{hot}.

  13. Simulation results of few-mode signal propagation over graded multimode optical fibers with periodical slowly varying core diameter

    NASA Astrophysics Data System (ADS)

    Bourdine, Anton V.

    2008-12-01

    Simulation results of few-mode signal propagation over silica graded multimode optical fibers with periodical slowly varying core diameter, excited by laser source, are represented. Weakly-guiding irregular multimode fibers with axialsymmetric graded index profile under central defect, local fluctuations and single outer cladding are considered. It is supposed, the core diameter varies slowly along fiber length according to sine function. The period of sine function is more then 106 times greater then fiber core diameter. Solution is based on proposed time domain model of piece-wise regular multimode fiber link under few-mode signal propagation under laser source exciting. Model takes into account differential mode delay, higher-order mode chromatic dispersion, mode mixing and power diffusion. Some results of pulse dynamics calculation during propagation over described fiber with periodical slowly varying core diameter are represented.

  14. The OmegaWhite Survey for short period variable stars - II. An overview of results from the first four years

    NASA Astrophysics Data System (ADS)

    Toma, R.; Ramsay, G.; Macfarlane, S.; Groot, P. J.; Woudt, P. A.; Dhillon, V.; Jeffery, C. S.; Marsh, T.; Nelemans, G.; Steeghs, D.

    2016-11-01

    OmegaWhite is a wide-field, high cadence, synoptic survey targeting fields in the southern Galactic plane, with the aim of discovering short period variable stars. Our strategy is to take a series of 39 s exposures in the g band of a 1 deg2 of sky lasting 2 h using the OmegaCAM wide field imager on the VLT Survey Telescope (VST). We give an overview of the initial 4 yr of data which covers 134 deg2 and includes 12.3 million light curves. As the fields overlap with the VLT Survey Telescope Hα Photometric Survey of the Galactic plane and Bulge (VPHAS+), we currently have ugriHα photometry for ˜1/3 of our fields. We find that a significant fraction of the light curves have been affected by the diffraction spikes of bright stars sweeping across stars within a few dozen of pixels over the two hour observing time interval due to the alt-az nature of the VST. We select candidate variable stars using a variety of variability statistics, followed by a manual verification stage. We present samples of several classes of short period variables, including: an ultra compact binary, a DQ white dwarf, a compact object with evidence of a 100 min rotation period, three CVs, one eclipsing binary with an 85 min period, a symbiotic binary which shows evidence of a 31 min photometric period, and a large sample of candidate δ Sct type stars including one with a 9.3 min period. Our overall goal is to cover 400 deg2, and this study indicates we will find many more interesting short period variable stars as a result.

  15. Higher Retail Prices of Sugar-Sweetened Beverages 3 Months After Implementation of an Excise Tax in Berkeley, California

    PubMed Central

    Rojas, Nadia; Grummon, Anna H.; Madsen, Kristine A.

    2015-01-01

    Objectives. We assessed the short-term ability to increase retail prices of the first US 1-cent-per-ounce excise tax on the distribution of sugar-sweetened beverages (SSBs), which was implemented in March 2015 by Berkeley, California. Methods. In 2014 and 2015, we examined pre- to posttax price changes of SSBs and non-SSBs in a variety of retailers in Berkeley and in the comparison cities Oakland and San Francisco, California. We examined price changes by beverage, brand, size, and retailer type. Results. For smaller beverages (≤ 33.8 oz), price increases (cents/oz) in Berkeley relative to those in comparison cities were 0.69 (95% confidence interval [CI] = 0.36, 1.03) for soda, 0.47 (95% CI = 0.08, 0.87) for fruit-flavored beverages, and 0.47 (95% CI = 0.25, 0.69) for SSBs overall. For 2-liter bottles and multipacks of soda, relative price increases were 0.46 (95% CI = 0.03, 0.89) and 0.49 (95% CI = 0.21, 0.77). We observed no relative price increases for nontaxed beverages overall. Conclusions. Approximately 3 months after the tax was implemented, SSB retail prices increased more in Berkeley than in nearby cities, marking a step in the causal pathway between the tax and reduced SSB consumption. PMID:26444622

  16. Auditory evoked arousal responses of 3-month-old infants exposed to methamphetamine in utero: a nap study

    PubMed Central

    Galland, Barbara C; Mitchell, Ed A; Thompson, John MD; Wouldes, Trecia

    2017-01-01

    Aim To investigate whether or not infants exposed to methamphetamine prenatally have impaired arousal responses from sleep. Methods The polygraphic nap studies involved 42 infants aged 3 months exposed to methamphetamine in utero and a comparison group of 57 infants. A proportion of mothers in both groups smoked cigarettes and/or marijuana and drank alcohol during pregnancy. White noise from 50 to 100 decibels (dB) was administered at 10 dB intervals twice within non-rapid eye movement (NREM) and rapid eye movement (REM) sleep states and arousal thresholds measured. Results Combining groups, 306 tests were completed (128 and 178 within REM and NREM sleep, respectively) and infants were more likely to wake at lower thresholds in REM than NREM sleep (hazard ratio 5.58; 95% CI, 3.78–8.23 p < 0.0001). No significant differences in arousal threshold were found between methamphetamine and comparison groups, before or after controlling for other substance use (NREM sleep; 0.98, 95% CI, 0.60–1.59 and REM sleep; 1.03, 95% CI, 0.56–1.89). Conclusions These findings suggest that arousal responses of methamphetamine-exposed infants remain intact, providing no support for the hypothesis that prenatal exposure could increase their vulnerability to sudden infant death syndrome (SIDS) through arousal deficits. PMID:23253105

  17. Ultra-short-period Planets in K2 SuPerPiG Results for Campaigns 0-5

    NASA Astrophysics Data System (ADS)

    Adams, Elisabeth R.; Jackson, Brian; Endl, Michael

    2016-08-01

    We analyzed data from Campaigns 0-5 of the K2 mission and report 19 ultra-short-period candidate planets with orbital periods of less than one day (nine of which have not been previously reported). Planet candidates range in size from 0.7 to 16 Earth radii and in orbital period from 4.2 to 23.5 hr. One candidate (EPIC 203533312, Kp = 12.5) is among the shortest-period planet candidates discovered to date (P=4.2 hr), and, if confirmed as a planet, must have a density of at least ρ =8.9 {{g}} {{cm}}-3 to not be tidally disrupted. Five candidates have nominal radius values in the sub-Jovian desert ({R}P=3{--}11 {R}\\oplus and P≤slant 1.5 days) where theoretical models do not favor their long-term stability; the only confirmed planet in this range is thought to be disintegrating (EPIC 201637175). In addition to the planet candidates, we report on four objects that may not be planetary, including one with intermittent transits (EPIC 211152484) and three initially promising candidates that are likely false positives based on characteristics of their light curves and on radial velocity follow-up. A list of 91 suspected eclipsing binaries identified at various stages in our vetting process is also provided. Based on an assessment of our survey's completeness, we estimate an occurrence rate for ultra-short-period planets among K2 target stars that is about half that estimated from the Kepler sample, raising questions as to whether K2 systems are intrinsically different from Kepler systems, possibly as a result of their different galactic location.

  18. Recognition of Faces and Greebles in 3-Month-Old Infants: Influence of Temperament and Cognitive Abilities

    ERIC Educational Resources Information Center

    Spangler, Sibylle M.; Freitag, Claudia; Schwarzer, Gudrun; Vierhaus, Marc; Teubert, Manuel; Lamm, Bettina; Kolling, Thorsten; Graf, Frauke; Goertz, Claudia; Fassbender, Ina; Lohaus, Arnold; Knopf, Monika; Keller, Heidi

    2011-01-01

    The aim of the present study was to investigate whether temperament and cognitive abilities are related to recognition performance of Caucasian and African faces and of a nonfacial stimulus class, Greebles. Seventy Caucasian infants were tested at 3 months with a habituation/dishabituation paradigm and their temperament and cognitive abilities…

  19. Prediction of glycated hemoglobin levels at 3 months after metabolic surgery based on the 7-day plasma metabolic profile.

    PubMed

    Kwon, Hyuk Nam; Lee, Yeon Ji; Kang, Ju-Hee; Choi, Ji-Ho; An, Yong Jin; Kang, Sunmi; Lee, Dae Hyun; Suh, Young Ju; Heo, Yoonseok; Park, Sunghyouk

    2014-01-01

    Metabolic surgery has been shown to provide better glycemic control for type 2 diabetes than conventional therapies. Still, the outcomes of the surgery are variable, and prognostic markers reflecting the metabolic changes by the surgery are yet to be established. NMR-based plasma metabolomics followed by multivariate regression was used to test the correlation between the metabolomic profile at 7-days after surgery and glycated hemoglobin (HbA1c) levels at 3-months (and up to 12 months with less patients), and to identify the relevant markers. Metabolomic profiles at 7-days could differentiate the patients according to the HbA1c improvement status at 3-months. The HbA1c values were predicted based on the metabolomics profile with partial least square regression, and found to be correlated with the observed values. Metabolite analysis suggested that 3-Hydroxybutyrate (3-HB) and glucose contributes to this prediction, and the [3-HB]/[glucose] exhibited a modest to good correlation with the HbA1c level at 3-months. The prediction of 3-month HbA1c using 7-day metabolomic profile and the suggested new criterion [3-HB]/[glucose] could augment current prognostic modalities and help clinicians decide if drug therapy is necessary.

  20. Externally Contingent and Unstable Self-Worth as Predictors of Depression in College Women: A 3-Month Study

    ERIC Educational Resources Information Center

    Lopez, Frederick G.; Thorne, Brittany; Schoenecker, Sydney; Siffert, Kevin; Chaliman, Rebecca; Castleberry, Erica

    2014-01-01

    Undergraduate women completed measures of externally contingent self-worth, self-esteem instability, and depression at the beginning (Time 1) and again 3 months later near the end (Time 2) of an academic semester. Findings indicated that when Time 1 depression scores were controlled for, each Time 1 facet of self-esteem made significant…

  1. Holistic Face Processing in Newborns, 3-Month-Old Infants, and Adults: Evidence from the Composite Face Effect

    ERIC Educational Resources Information Center

    Turati, Chiara; Di Giorgio, Elisa; Bardi, Lara; Simion, Francesca

    2010-01-01

    Holistic face processing was investigated in newborns, 3-month-old infants, and adults through a modified version of the composite face paradigm and the recording of eye movements. After familiarization to the top portion of a face, participants (N = 70) were shown 2 aligned or misaligned faces, 1 of which comprised the familiar top part. In the…

  2. Lown-Ganong-Levine syndrome in a 3-month-old infant with isolated left ventricular noncompaction.

    PubMed

    Shabanian, Reza; Kiani, Abdolrazagh; Rad, Elaheh Malakan; Eslamiyeh, Hosein

    2010-02-01

    This report describes a 3-month-old boy with isolated left ventricular noncompaction admitted to a medical facility due to heart failure and dysrhythmia. His electrocardiogram showed a short PR interval and a normal QRS complex after abortion of supraventricular tachycardia in favor of Lown-Ganong-Levine syndrome or enhanced atrioventricular nodal conduction.

  3. A 3-Month Jump-Landing Training Program: A Feasibility Study Using the RE-AIM Framework

    PubMed Central

    Aerts, Inne; Cumps, Elke; Verhagen, Evert; Mathieu, Niels; Van Schuerbeeck, Sander; Meeusen, Romain

    2013-01-01

    Context: Evaluating the translatability and feasibility of an intervention program has become as important as determining the effectiveness of the intervention. Objective: To evaluate the applicability of a 3-month jump-landing training program in basketball players, using the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework. Design: Randomized controlled trial. Setting: National and regional basketball teams. Patients or Other Participants: Twenty-four teams of the second highest national division and regional basketball divisions in Flanders, Belgium, were randomly assigned (1:1) to a control group and intervention group. A total of 243 athletes (control group = 129, intervention group = 114), ages 15 to 41 years, volunteered. Intervention(s): All exercises in the intervention program followed a progressive development, emphasizing lower extremity alignment during jump-landing activities. Main Outcome Measure(s): The results of the process evaluation of the intervention program were based on the 5 dimensions of the RE-AIM framework. The injury incidence density, hazard ratios, and 95% confidence intervals were determined. Results: The participation rate of the total sample was 100% (reach). The hazard ratio was different between the intervention group and the control group (0.40 [95% confidence interval = 0.16, 0.99]; effectiveness). Of the 12 teams in the intervention group, 8 teams (66.7%) agreed to participate in the study (adoption). Eight of the participating coaches (66.7%) felt positively about the intervention program and stated that they had implemented the training sessions of the program as intended (implementation). All coaches except 1 (87.5%) intended to continue the intervention program the next season (maintenance). Conclusions: Compliance of the coaches in this coach-supervised jump-landing training program was high. In addition, the program was effective in preventing lower extremity injuries. PMID:23675788

  4. Infant Temperament and Parent Stress in 3 month old Infants following Surgery for Complex Congenital Heart Disease

    PubMed Central

    Torowicz, Deborah; Irving, Sharon Y; Hanlon, Alexandra L.; Sumpter, Danica Fulbright; Medoff-Cooper, Barbara

    2010-01-01

    Objective This study aimed to identify and compare differences in temperament and maternal stress between infants with complex congenital heart disease (CHD) and healthy controls at 3 months of age. Methods Study sample was drawn from an existing longitudinal study examining growth in infants with CHD as compared to healthy controls. Infant temperament and parental stress were measured in 129 mother-infant dyads. Inclusion criteria for infants with CHD were ≥ 36 weeks post-menstrual age, ≥ 2500 grams at birth, surgery in first 6 weeks of life, and no major congenital anomalies or genetic syndromes. The Early Infancy Temperament Questionnaire and Parent Stress Index were the assessment tools used. Results Infants with single ventricle (SV) physiology were more negative in mood (F=7.14, p<0.001) and less distractible (F=5.00, p<0.008) than the biventricular physiology (BV) or control (C) infant groups. The demands of care for infants with CHD was a source of stress as compared to control infants (p<.05). Five of six subscales of the Child Domain were significant sources of stress in the SV group compared to BV and Control groups. Negative mood and difficulty to soothe were predictors for Child Domain and Total Life Stress in SV infants. Conclusion The demands of parenting an irritable infant with SV physiology puts these mothers at risk for high levels of stress. Results suggest the need for pre-discharge anticipatory guidance for parents to better understand and respond to the behavioral style of their infants, in particular, infants with SV physiology. PMID:20375737

  5. Mother-preterm infant interactions at 3 months of corrected age: influence of maternal depression, anxiety and neonatal birth weight

    PubMed Central

    Neri, Erica; Agostini, Francesca; Salvatori, Paola; Biasini, Augusto; Monti, Fiorella

    2015-01-01

    Maternal depression and anxiety represent risk factors for the quality of early mother-preterm infant interactions, especially in the case of preterm birth. Despite the presence of many studies on this topic, the comorbidity of depressive and anxious symptoms has not been sufficiently investigated, as well as their relationship with the severity of prematurity and the quality of early interactions. The Aim of this study was to evaluate the quality of early mother-infant interactions and the prevalence of maternal depression and anxiety comparing dyads of extremely low birth weight (ELBW) and very low birth weight (VLBW) preterm infants with full-term ones. Seventy seven preterm infants (32 ELBW; 45 VLBW) and 120 full term (FT) infants and their mothers were recruited. At 3 months of corrected age, 5 min of mother-infant interactions were recorded and later coded through the Global Ratings Scales. Mothers completed the Edinburgh Postnatal Depression Scale and Penn State Worry Questionnaire. Infant levels of development were assessed through the Griffiths Mental Development Scales. A relation emerged among the severity of prematurity, depression, anxiety, and the quality of interactions. When compared with the FT group, the ELBW interactions were characterized by high maternal intrusiveness and low remoteness, while the VLBW dyads showed high levels of maternal sensitivity and infant communication. Depression was related to maternal remoteness and negative affective state, anxiety to low sensitivity, while infant interactive behaviors were impaired only in case of comorbidity. ELBW’s mothers showed the highest prevalence of depressive and anxious symptoms; moreover, only in FT dyads, low maternal sensitivity, negative affective state and minor infant communication were associated to the presence of anxious symptoms. The results confirmed the impact of prematurity on mother–infant interactions and on maternal affective state. Early diagnosis can help to plan

  6. How a hat may affect 3-month-olds' recognition of a face: an eye-tracking study.

    PubMed

    Bulf, Hermann; Valenza, Eloisa; Turati, Chiara

    2013-01-01

    Recent studies have shown that infants' face recognition rests on a robust face representation that is resilient to a variety of facial transformations such as rotations in depth, motion, occlusion or deprivation of inner/outer features. Here, we investigated whether 3-month-old infants' ability to represent the invariant aspects of a face is affected by the presence of an external add-on element, i.e. a hat. Using a visual habituation task, three experiments were carried out in which face recognition was investigated by manipulating the presence/absence of a hat during face encoding (i.e. habituation phase) and face recognition (i.e. test phase). An eye-tracker system was used to record the time infants spent looking at face-relevant information compared to the hat. The results showed that infants' face recognition was not affected by the presence of the external element when the type of the hat did not vary between the habituation and test phases, and when both the novel and the familiar face wore the same hat during the test phase (Experiment 1). Infants' ability to recognize the invariant aspects of a face was preserved also when the hat was absent in the habituation phase and the same hat was shown only during the test phase (Experiment 2). Conversely, when the novel face identity competed with a novel hat, the hat triggered the infants' attention, interfering with the recognition process and preventing the infants' preference for the novel face during the test phase (Experiment 3). Findings from the current study shed light on how faces and objects are processed when they are simultaneously presented in the same visual scene, contributing to an understanding of how infants respond to the multiple and composite information available in their surrounding environment.

  7. The Explorer XVI Micrometeoroid Satellite Description and Preliminary Results for the Period December 16, 1962 Through January 13, 1963

    NASA Technical Reports Server (NTRS)

    Hastings, E. C., Jr.

    1963-01-01

    Explorer XVI (1962 Beta Chi l) data that have been analyzed for the period between December 16, 1962 (launch date), and January 13, 1963, indicate that the orbit achieved was close to the predicted orbit. Ten punctures of annealed 0.001-inch-thick beryllium-copper have been used to determine a puncture rate of 0.035 per square foot per day in this material. One puncture of a 0.002-inch-thick sample has also occurred in this period. A tentative evaluation of the puncture rate for the 0.001-inch beryllium-copper in terms of the rate for an equivalent thickness of aluminum has been attempted, and the result has been compared with two different puncture rate estimates. The three micrometeoroid impact detecting systems are operating. Counting rates for the high- and low-sensitivity systems were close to anticipated values near the end of one week. Two of the 0.001-inch-steel-covered grid detectors have been punctured, but none of the 0.003- or 0.006-inch-steel-covered grid detectors have indicated punctures. One of the cadmium sulfide cells indicates three punctures of the 0.00025-inch Mylar cover. None of the 0.002- or 0.003-inch-copper-wire cards have indicated a break in the period covered. Telemetry temperatures were initially higher than expected although they remained well within operating limits. Sensor temperatures have remained within the expected bounds.

  8. Breastfeeding Self-Efficacy Scale: Validation of the Italian Version and Correlation With Breast-feeding at 3 Months.

    PubMed

    Petrozzi, Angela; Gagliardi, Luigi

    2016-01-01

    Psychological factors can influence breast-feeding. We translated into Italian and validated the Breastfeeding Self-Efficacy Scale Short Form (BSES-SF) and investigated its predictive ability and its relation with postpartum depression symptoms.BSES-SF and Edinburgh Postnatal Depression Scale (EPDS) were administered 2 to 3 days after delivery to 122 mothers. Breast-feeding was assessed at 3 months.The BSES-SF displayed good validity (receiver operating characteristic area = 0.69) for predicting full breast-feeding at 3 months. In multivariate analysis, the probability of full breast-feeding increased 2.4% for 1-point increase of BSES-SF. The BSES-SF and EPDS scores were inversely correlated. BSES-SF is a useful tool to identify the risk of early breast-feeding attrition.

  9. 3-Month experience in presbyopic correction with bi-aspheric multifocal central presbyLASIK treatments for hyperopia and myopia with or without astigmatism

    PubMed Central

    Luger, Michiel H.A.; Ewering, Tobias; Arba-Mosquera, Samuel

    2012-01-01

    Purpose To analyze simultaneous vision (distance and near) 3-month after bi-aspheric multifocal central presbyLASIK treatments for hyperopia and myopia with or without astigmatism. Methods Retrospective study analyzing patients that had been treated for correcting distance ametropiae and alleviating presbyopic symptoms simultaneously. All patients had been treated in Presby Aspheric mode using FemtoLASIK. No eye had previous corneal refractive surgery. Preoperative corneal curvature ranged between 40 D and 48 D, with pachymetry thicker than 500 μm. Preoperative best distance corrected visual acuity (CDVA) was 0.1 LogMAR or better, with best corrected near vision (CNVA) of 0.2 LogRAD or better. Results 66 patients treated using PresbyMAX software (SCHWIND eye-tech-solutions GmbH and Co. KG, Kleinostheim, Germany) were reviewed. For 24 patients, 3-month follow-up was completed. At 3 months, 71% of patients achieved UDVA 0.1 LogMAR or better, 79% patients obtained UNVA 0.1 LogRAD or better, and 83% of eyes were within 0.75 diopters (D) of defocus. Postoperative mean spherical equivalent refraction was −0.15 ± 0.50 D. Stability was achieved from the 6-week follow-up. 92% of patients achieved UDVA 0.2 LogMAR or better and UNVA 0.2 LogRAD or better. No statistical differences between myopes/hyperopes or between males/females were found. Conclusions Patient selection and expectation management are essential to achieve patient satisfaction. Even though optically the results are quite predictable, some patients find it difficult to adapt to the compromise between far and near vision, and others are dissatisfied by the minor loss of distance VA.

  10. The effect of a 3-month moderate-intensity physical activity program on body composition in overweight and obese African American college females

    PubMed Central

    Casazza, K.; Durant, N. H.

    2014-01-01

    Summary This study evaluated body composition outcomes following a 3-month exercise program for overweight/obese Black women. BMI decreased over the 3-month study despite an observed increase in body fat. Enhancements in bone marrow density and muscle density were also observed. Results show promising yet hypothesis-generating findings to explore in future research. Introduction Few studies have evaluated the relationship between aerobic physical activity (PA) and body composition among young adult overweight/obese African American (AA) women. Purpose The current study evaluated the effect of a 3-month moderate-intensity aerobic physical activity intervention for overweight and obese young adult women on bone, lean, and fat mass. Methods Participants (n=15) were a randomly selected subset of AA female college students (M age=21.7 years; M BMI= 33.3) enrolled in a larger PA promotion pilot study (n=31). Study protocol required participants to engage in four 30–60-min moderate-intensity aerobic PA sessions each week. Whole body composition was measured by dual-energy X-ray absorptiometry (DXA), and peripheral quantitative computed tomography (pQCT) was used to assess additional quantitative and qualitative assessment of the radius. Results BMI decreased over the duration of the study (P=.034), reflected by a marginal decrease in body weight (P=.057). However, unexpectedly, increases in adipose tissue measures were observed, including total body fat (P=.041), percent body fat (P=.044), trunk fat (P=.031), and percent trunk fat (P=.041). No changes in DXA-measured bone outcomes were observed (i.e., bone mineral density, P=.069; bone mineral content, P=.211). Results from the pQCT assessment showed that bone marrow density increased (P=.011), but cortical density remained stable (P=.211). A marginally significant increase in muscle density (P=.053) and no changes in muscle area (P=.776) were observed. Conclusions A 3-month moderate-intensity PA program was associated

  11. Pivotal Response Treatment Parent Training for Autism: Findings from a 3-Month Follow-Up Evaluation

    ERIC Educational Resources Information Center

    Gengoux, Grace W.; Berquist, Kari L.; Salzman, Emma; Schapp, Salena; Phillips, Jennifer M.; Frazier, Thomas W.; Minjarez, Mendy B.; Hardan, Antonio Y.

    2015-01-01

    This study's objective was to assess maintenance of treatment effects 3 months after completion of a 12-week Pivotal Response Treatment (PRT) parent education group. Families who completed the active treatment (N = 23) were followed for an additional 12 weeks to measure changes in language and cognitive skills. Results indicated a significant…

  12. Visual stimulation enhances auditory processing in 3-month-old infants and adults.

    PubMed

    Hyde, Daniel C; Jones, Blake L; Porter, Chris L; Flom, Ross

    2010-03-01

    Behavioral work demonstrates human infants are sensitive to a host of intersensory properties and this sensitivity promotes early learning and memory. However, little is known regarding the neural basis of this ability in infants. Using event-related potentials (ERPs) with infants and adults, we show that during passive viewing auditory evoked brain responses are increased with the presence of simultaneous visual stimulation. Results converge with previous adult neuroimaging studies, single-cell recordings in nonhuman animals, and behavioral studies with human infants to provide evidence for an elevated status of multisensory stimulation in infancy. Furthermore, these results may provide a neural marker of multisensory audio-visual processing in infants that can be used to test developmental theories of how information is integrated across the senses to form a unitary perception of the world.

  13. Results of dose sensors measurements in the middle-Earth orbit for the period of 2009-2015

    NASA Astrophysics Data System (ADS)

    Protopopov, Grigory; Shatov, Pavel; Tasenko, Sergey; Lyakhov, Igor; Makarova, Nina; Balashov, Sergey; Sitnikova, Ninel

    2016-07-01

    The measurements results of space radiation exposure on electronic components carried out by dose sensors are presented in the paper. Dose sensors operate on metal-nitride-oxide-semiconductor dosimetry pricniple. The flight data have been receiving for more than 6 years. The measurements results are compared with others flight data on different orbits. The analysis of the received data from 2009 to 2015 allows us to find out the periods with sharp increase of dose rate and to define values of such increases. We had analyzed space radiation characteristics data from other monitoring systems (such as GOES, Electro-L) in dates of dose rate sharp increase. Results of the analysis of dose rate increase, which had been fixed by TID sensors in 2015, will be presented in full paper. We had calculated average dose rates for different space models in the middle-Earth orbit (AE8, AE9 and others) and determined the most relevant models to the experimental data (with account for relaxation effect of dose sensor outputs). The comparison results for different models will be presented in the full paper. We had used different approaches for simulating of dose sensors shielding geometry, such as semi-sphere, semi-infinite plate, sector analysis, with taking account of different shielding elements. The analysis results of shielding configuration influence on calculated values of dose rate will be presented in the full paper.

  14. Robot-Assisted Rehabilitation of Ankle Plantar Flexors Spasticity: A 3-Month Study with Proprioceptive Neuromuscular Facilitation.

    PubMed

    Zhou, Zhihao; Sun, Yao; Wang, Ninghua; Gao, Fan; Wei, Kunlin; Wang, Qining

    2016-01-01

    In this paper, we aim to investigate the effect of proprioceptive neuromuscular facilitation (PNF)-based rehabilitation for ankle plantar flexors spasticity by using a Robotic Ankle-foot Rehabilitation System (RARS). A modified robot-assisted system was proposed, and seven poststroke patients with hemiplegic spastic ankles participated in a 3-month robotic PNF training. Their impaired sides were used as the experimental group, while their unimpaired sides as the control group. A robotic intervention for the experimental group started from a 2-min passive stretching to warming-up or relaxing the soleus and gastrocnemius muscles and also ended with the same one. Then a PNF training session including 30 trials was activated between them. The rehabilitation trainings were carried out three times a week as an addition to their regular rehabilitation exercise. Passive range of motion, resistance torque, and stiffness were measured in both ankles before and after the interventions. The changes in Achilles tendon length, walking speed, and lower limb function were also evaluated by the same physician or physiotherapist for each participant. Biomechanical measurements before interventions showed significant difference between the experimental group and the control group due to ankle spasticity. For the control group, there was no significant difference in the 3 months with no robotic intervention. But for the experimental group, passive dorsiflexion range of motion increased (p < 0.01), resistance torque under different dorsiflexion angle levels (0°, 10°, and 20°) decreased (p < 0.05, p < 0.001, and p < 0.001, respectively), and quasi-static stiffness under different dorsiflexion angle levels (0°, 10°, and 20°) also decreased (p < 0.01, p < 0.001, and p < 0.001, respectively). Achilles's tendon length shortened (p < 0.01), while its thickness showed no significant change (p > 0.05). The robotic rehabilitation also improved the

  15. Robot-Assisted Rehabilitation of Ankle Plantar Flexors Spasticity: A 3-Month Study with Proprioceptive Neuromuscular Facilitation

    PubMed Central

    Zhou, Zhihao; Sun, Yao; Wang, Ninghua; Gao, Fan; Wei, Kunlin; Wang, Qining

    2016-01-01

    In this paper, we aim to investigate the effect of proprioceptive neuromuscular facilitation (PNF)-based rehabilitation for ankle plantar flexors spasticity by using a Robotic Ankle–foot Rehabilitation System (RARS). A modified robot-assisted system was proposed, and seven poststroke patients with hemiplegic spastic ankles participated in a 3-month robotic PNF training. Their impaired sides were used as the experimental group, while their unimpaired sides as the control group. A robotic intervention for the experimental group started from a 2-min passive stretching to warming-up or relaxing the soleus and gastrocnemius muscles and also ended with the same one. Then a PNF training session including 30 trials was activated between them. The rehabilitation trainings were carried out three times a week as an addition to their regular rehabilitation exercise. Passive range of motion, resistance torque, and stiffness were measured in both ankles before and after the interventions. The changes in Achilles tendon length, walking speed, and lower limb function were also evaluated by the same physician or physiotherapist for each participant. Biomechanical measurements before interventions showed significant difference between the experimental group and the control group due to ankle spasticity. For the control group, there was no significant difference in the 3 months with no robotic intervention. But for the experimental group, passive dorsiflexion range of motion increased (p < 0.01), resistance torque under different dorsiflexion angle levels (0°, 10°, and 20°) decreased (p < 0.05, p < 0.001, and p < 0.001, respectively), and quasi-static stiffness under different dorsiflexion angle levels (0°, 10°, and 20°) also decreased (p < 0.01, p < 0.001, and p < 0.001, respectively). Achilles’s tendon length shortened (p < 0.01), while its thickness showed no significant change (p > 0.05). The robotic rehabilitation also improved the

  16. Low-dose modified-release prednisone in axial spondyloarthritis: 3-month efficacy and tolerability

    PubMed Central

    Bandinelli, Francesca; Scazzariello, Francesco; Pimenta da Fonseca, Emanuela; Barreto Santiago, Mittermayer; Marcassa, Claudio; Nacci, Francesca; Matucci Cerinic, Marco

    2016-01-01

    Background Oral glucocorticoids (GCs) have been shown to be effective in reducing the inflammatory symptoms of rheumatoid arthritis, but their use is not supported by evidence in spondyloarthritis (SpA). Modified-release (MR) oral prednisone taken at bedtime has been shown to be more effective than immediate-release prednisone taken in the morning. The efficacy of low-dose MR prednisolone in patients with SpA is unknown. Patients and methods This single-center cohort study retrospectively assessed the effectiveness and safety of 12-week low-dose MR prednisone (5 mg daily, bedtime administration) in GC-naïve adult patients with symptomatic axial SpA. A 50% improvement of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) or a final BASDAI score of <4 according to disease activity at baseline was chosen as the primary outcome parameter after MR prednisone. Results Fifty-seven patients were evaluated; of them, 41 had an active disease (BASDAI score of ≥4) at baseline. MR prednisone significantly reduced BASDAI (from 5.5±2.6 to 3.0±2.8, P<0.001) as well as inflammatory symptoms, pain, fatigue and morning stiffness. The overall response rate after MR prednisone was 52.6% (53.7% in patients with active SpA and 50.0% in patients with low-active disease; nonsignificant). At multivariable analysis, none of the considered clinical findings independently predicted the response to MR prednisone in subjects with active SpA. Overall, seven patients (11.8%) had nonserious adverse drug reactions after MR prednisone. Conclusion In patients with symptomatic SpA and naïve to GCs, low-dose MR prednisone reduced the symptoms and clinical indexes of disease activity and showed a positive safety profile. PMID:27881910

  17. UV/Visible Aerosol Extinction Measurements performed by GOMOS onboard ENVISAT: results for the period August 2002 to March 2005.

    NASA Astrophysics Data System (ADS)

    Vanhellemont, F.; Fussen, D.; Dodion, J.; Bingen, C.; Mateshvili, N.; Gomos Team

    Launched in March 2002 the GOMOS Global Ozone Monitoring by Occultation of Stars instrument onboard the European Envisat satellite has already provided a wealth of information on the geographical and temporal distribution of several atmospheric species Vertical profiles for these species are numerically retrieved from measurements of starlight that is transmitted through the atmosphere at different tangent altitudes The actual spectrum at each tangent altitude is measured within the UV Visible wavelength range Typically within the useful range from 248 nm to 690 nm gas concentration profiles for O 3 NO 2 H 2 O neutral air and aerosol extinction profiles can be retrieved Although stars are relatively weak light sources the advantage of the star occultation lies in the fact that useful stars are available at all times during orbit As a consequence GOMOS has measured more than 300 000 occultations in the considered period from August 2002 to March 2005 In this work we present results for the aerosol extinction retrievals Using selection criteria for different occultation properties such as the star magnitude and the illumination conditions a subset of reliable occultations were picked Subsequently a spatial and temporal binning was performed and data were averaged The resulting climatology provides a good view on the spatial distribution and temporal evolution of aerosols in the stratosphere Special attention is given to the presence of PSCs in the Antarctic polar vortex and equatorial cirrus clouds First results on particle sizes

  18. Periodontal health status in patients treated with the Invisalign® system and fixed orthodontic appliances: A 3 months clinical and microbiological evaluation

    PubMed Central

    Levrini, Luca; Mangano, Alessandro; Montanari, Paola; Margherini, Silvia; Caprioglio, Alberto; Abbate, Gian Marco

    2015-01-01

    Objective: The aim of this prospective study was to compare the periodontal health and the microbiological changes via real-time polymerase chain reaction (PCR) in patients treated with fixed orthodontic appliances and Invisalign® system (Align Technology, Santa Clara, California). Materials and Methods: Seventy-seven patients were enrolled in this study and divided into three groups (Invisalign® group, fixed orthodontic appliances group and control group). Plaque index, probing depth, bleeding on probing were assessed. Total biofilm mass and periodontal pathogens were analyzed and detected via real-time PCR. All these data were analyzed at the T0 (beginning of the treatment) T1 (1-month) and T2 (3 months); and statistically compared using the Mann–Whitney test for independent groups. Results: After 1-month and after 3 months of treatment there was only one sample with periodontopathic anaerobes found in patient treated using fixed orthodontic appliances. The Invisalign® group showed better results in terms of periodontal health and total biofilm mass compared to the fixed orthodontic appliance group. A statistical significant difference (P < 0.05) at the T2 in the total biofilm mass was found between the two groups. Conclusion: Patients undergoing orthodontic treatment with the Invisalign® System show a superior periodontal health in the short-term when compared to patients in treatment with fixed orthodontic appliances. Invisalign® should be considered as a first treatment option in patients with risk of developing periodontal disease. PMID:26430371

  19. Searches for periodic gravitational waves from unknown isolated sources and Scorpius X-1: Results from the second LIGO science run

    NASA Astrophysics Data System (ADS)

    Abbott, B.; Abbott, R.; Adhikari, R.; Agresti, J.; Ajith, P.; Allen, B.; Amin, R.; Anderson, S. B.; Anderson, W. G.; Arain, M.; Araya, M.; Armandula, H.; Ashley, M.; Aston, S.; Aufmuth, P.; Aulbert, C.; Babak, S.; Ballmer, S.; Bantilan, H.; Barish, B. C.; Barker, C.; Barker, D.; Barr, B.; Barriga, P.; Barton, M. A.; Bayer, K.; Belczynski, K.; Berukoff, S. J.; Betzwieser, J.; Beyersdorf, P. T.; Bhawal, B.; Bilenko, I. A.; Billingsley, G.; Biswas, R.; Black, E.; Blackburn, K.; Blackburn, L.; Blair, B.; Bland, B.; Bogenstahl, J.; Bogue, L.; Bork, R.; Boschi, V.; Bose, S.; Brady, P. R.; Braginsky, V. B.; Brau, J. E.; Brinkmann, M.; Brooks, A.; Brown, D. A.; Bullington, A.; Bunkowski, A.; Buonanno, A.; Burmeister, O.; Busby, D.; Butler, W. E.; Byer, R. L.; Cadonati, L.; Cagnoli, G.; Camp, J. B.; Cannizzo, J.; Cannon, K.; Cantley, C. A.; Cao, J.; Cardenas, L.; Carter, K.; Casey, M. M.; Castaldi, G.; Cepeda, C.; Chalkey, E.; Charlton, P.; Chatterji, S.; Chelkowski, S.; Chen, Y.; Chiadini, F.; Chin, D.; Chin, E.; Chow, J.; Christensen, N.; Clark, J.; Cochrane, . P.; Cokelaer, T.; Colacino, C. N.; Coldwell, R.; Coles, M.; Conte, R.; Cook, D.; Corbitt, T.; Coward, D.; Coyne, D.; Creighton, J. D. E.; Creighton, T. D.; Croce, R. P.; Crooks, D. R. M.; Cruise, A. M.; Csatorday, P.; Cumming, A.; Cutler, C.; Dalrymple, J.; D'Ambrosio, E.; Danzmann, K.; Davies, G.; Daw, E.; Debra, D.; Degallaix, J.; Degree, M.; Delker, T.; Demma, T.; Dergachev, V.; Desai, S.; Desalvo, R.; Dhurandhar, S.; Díaz, M.; Dickson, J.; di Credico, A.; Diederichs, G.; Dietz, A.; Ding, H.; Doomes, E. E.; Drever, R. W. P.; Dumas, J.-C.; Dupuis, R. J.; Dwyer, J. G.; Ehrens, P.; Espinoza, E.; Etzel, T.; Evans, M.; Evans, T.; Fairhurst, S.; Fan, Y.; Fazi, D.; Fejer, M. M.; Finn, L. S.; Fiumara, V.; Fotopoulos, N.; Franzen, A.; Franzen, K. Y.; Freise, A.; Frey, R.; Fricke, T.; Fritschel, P.; Frolov, V. V.; Fyffe, M.; Galdi, V.; Ganezer, K. S.; Garofoli, J.; Gholami, I.; Giaime, J. A.; Giampanis, S.; Giardina, K. D.; Goda, K.; Goetz, E.; Goggin, L. M.; González, G.; Gossler, S.; Grant, A.; Gras, S.; Gray, C.; Gray, M.; Greenhalgh, J.; Gretarsson, A. M.; Grosso, R.; Grote, H.; Grunewald, S.; Guenther, M.; Gustafson, R.; Hage, B.; Hammer, D.; Hanna, C.; Hanson, J.; Harms, J.; Harry, G.; Harstad, E.; Hayler, T.; Heefner, J.; Heinzel, G.; Heng, I. S.; Heptonstall, A.; Heurs, M.; Hewitson, M.; Hild, S.; Hirose, E.; Hoak, D.; Hosken, D.; Hough, J.; Howell, E.; Hoyland, D.; Huttner, S. H.; Ingram, D.; Innerhofer, E.; Ito, M.; Itoh, Y.; Ivanov, A.; Jackrel, D.; Jennrich, O.; Johnson, B.; Johnson, W. W.; Johnston, W. R.; Jones, D. I.; Jones, G.; Jones, R.; Ju, L.; Kalmus, P.; Kalogera, V.; Kasprzyk, D.; Katsavounidis, E.; Kawabe, K.; Kawamura, S.; Kawazoe, F.; Kells, W.; Keppel, D. G.; Khalili, F. Ya.; Killow, C. J.; Kim, C.; King, P.; Kissell, J. S.; Klimenko, S.; Kokeyama, K.; Kondrashov, V.; Kopparapu, R. K.; Kozak, D.; Krishnan, B.; Kwee, P.; Lam, P. K.; Landry, M.; Lantz, B.; Lazzarini, A.; Lee, B.; Lei, M.; Leiner, J.; Leonhardt, V.; Leonor, I.; Libbrecht, K.; Libson, A.; Lindquist, P.; Lockerbie, N. A.; Logan, J.; Longo, M.; Lormand, M.; Lubiński, M.; Lück, H.; Machenschalk, B.; Macinnis, M.; Mageswaran, M.; Mailand, K.; Malec, M.; Mandic, V.; Marano, S.; Márka, S.; Markowitz, J.; Maros, E.; Martin, I.; Marx, J. N.; Mason, K.; Matone, L.; Matta, V.; Mavalvala, N.; McCarthy, R.; McClelland, D. E.; McGuire, S. C.; McHugh, M.; McKenzie, K.; McNabb, J. W. C.; McWilliams, S.; Meier, T.; Melissinos, A.; Mendell, G.; Mercer, R. A.; Meshkov, S.; Messaritaki, E.; Messenger, C. J.; Meyers, D.; Mikhailov, E.; Mitra, S.; Mitrofanov, V. P.; Mitselmakher, G.; Mittleman, R.; Miyakawa, O.; Mohanty, S.; Moreno, G.; Mossavi, K.; Mowlowry, C.; Moylan, A.; Mudge, D.; Mueller, G.; Mukherjee, S.; Müller-Ebhardt, H.; Munch, J.; Murray, P.; Myers, E.; Myers, J.; Nagano, S.; Nash, T.; Newton, G.; Nishizawa, A.; Nocera, F.; Numata, K.; Nutzman, P.; O'Reilly, B.; O'Shaughnessy, R.; Ottaway, D. J.; Overmier, H.; Owen, B. J.; Pan, Y.; Papa, M. A.; Parameshwaraiah, V.; Parameswariah, C.; Patel, P.; Pedraza, M.; Penn, S.; Pierro, V.; Pinto, I. M.; Pitkin, M.; Pletsch, H.; Plissi, M. V.; Postiglione, F.; Prix, R.; Quetschke, V.; Raab, F.; Rabeling, D.; Radkins, H.; Rahkola, R.; Rainer, N.; Rakhmanov, M.; Ramsunder, M.; Rawlins, K.; Ray-Majumder, S.; Re, V.; Regimbau, T.; Rehbein, H.; Reid, S.; Reitze, D. H.; Ribichini, L.; Richman, S.; Riesen, R.; Riles, K.; Rivera, B.; Robertson, N. A.; Robinson, C.; Robison, E. L.; Roddy, S.; Rodriguez, A.; Rogan, A. M.; Rollins, J.; Romano, J. D.; Romie, J.; Rong, H.; Route, R.; Rowan, S.; Rüdiger, A.; Ruet, L.; Russell, P.; Ryan, K.; Sakata, S.; Samidi, M.; Sancho de La Jordana, L.; Sandberg, V.; Sanders, G. H.; Sannibale, V.; Saraf, S.; Sarin, P.; Sathyaprakash, B.; Sato, S.; Saulson, P. R.; Savage, R.; Savov, P.; Sazonov, A.; Schediwy, S.; Schilling, R.; Schnabel, R.; Schofield, R.; Schutz, B. F.; Schwinberg, P.; Scott, S. M.; Searle, A. C.; Sears, B.; Seifert, F.; Sellers, D.; Sengupta, A. S.; Shawhan, P.; Shoemaker, D. H.; Sibley, A.; Sidles, J. A.; Siemens, X.; Sigg, D.; Sinha, S.; Sintes, A. M.; Slagmolen, B. J. J.; Slutsky, J.; Smith, J. R.; Smith, M. R.; Somiya, K.; Strain, K. A.; Strand, N. E.; Strom, D. M.; Stuver, A.; Summerscales, T. Z.; Sun, K.-X.; Sung, M.; Sutton, P. J.; Sylvestre, J.; Takahashi, H.; Takamori, A.; Tanner, D. B.; Tarallo, M.; Taylor, R.; Taylor, R.; Thacker, J.; Thorne, K. A.; Thorne, K. S.; Thüring, A.; Tinto, M.; Tokmakov, K. V.; Torres, C.; Torrie, C.; Traylor, G.; Trias, M.; Tyler, W.; Ugolini, D.; Ungarelli, C.; Urbanek, K.; Vahlbruch, H.; Vallisneri, M.; van den Broeck, C.; van Putten, M.; Varvella, M.; Vass, S.; Vecchio, A.; Veitch, J.; Veitch, P.; Villar, A.; Vorvick, C.; Vyachanin, S. P.; Waldman, S. J.; Wallace, L.; Ward, H.; Ward, R.; Watts, K.; Webber, D.; Weidner, A.; Weinert, M.; Weinstein, A.; Weiss, R.; Wen, L.; Wen, S.; Wette, K.; Whelan, J. T.; Whitbeck, D.. M.; Whitcomb, S. E.; Whiting, B. F.; Wiley, S.; Wilkinson, C.; Willems, P. A.; Williams, L.; Willke, B.; Wilmut, I.; Winkler, W.; Wipf, C. C.; Wise, S.; Wiseman, A. G.; Woan, G.; Woods, D.; Wooley, R.; Worden, J.; Wu, W.; Yakushin, I.; Yamamoto, H.; Yan, Z.; Yoshida, S.; Yunes, N.; Zaleski, K. D.; Zanolin, M.; Zhang, J.; Zhang, L.; Zhao, C.; Zotov, N.; Zucker, M.; Zur Mühlen, H.; Zweizig, J.

    2007-10-01

    We carry out two searches for periodic gravitational waves using the most sensitive few hours of data from the second LIGO science run. Both searches exploit fully coherent matched filtering and cover wide areas of parameter space, an innovation over previous analyses which requires considerable algorithm development and computational power. The first search is targeted at isolated, previously unknown neutron stars, covers the entire sky in the frequency band 160 728.8 Hz, and assumes a frequency derivative of less than 4×10-10Hz/s. The second search targets the accreting neutron star in the low-mass x-ray binary Scorpius X-1 and covers the frequency bands 464 484 Hz and 604 624 Hz as well as the two relevant binary orbit parameters. Because of the high computational cost of these searches we limit the analyses to the most sensitive 10 hours and 6 hours of data, respectively. Given the limited sensitivity and duration of the analyzed data set, we do not attempt deep follow-up studies. Rather we concentrate on demonstrating the data analysis method on a real data set and present our results as upper limits over large volumes of the parameter space. In order to achieve this, we look for coincidences in parameter space between the Livingston and Hanford 4-km interferometers. For isolated neutron stars our 95% confidence level upper limits on the gravitational wave strain amplitude range from 6.6×10-23 to 1×10-21 across the frequency band; for Scorpius X-1 they range from 1.7×10-22 to 1.3×10-21 across the two 20-Hz frequency bands. The upper limits presented in this paper are the first broadband wide parameter space upper limits on periodic gravitational waves from coherent search techniques. The methods developed here lay the foundations for upcoming hierarchical searches of more sensitive data which may detect astrophysical signals.

  20. New constraints on the variation of the geomagnetic field during the late Neolithic period: Archaeointensity results from Sichuan, southwestern China

    NASA Astrophysics Data System (ADS)

    Cai, Shuhui; Chen, Wei; Tauxe, Lisa; Deng, Chenglong; Qin, Huafeng; Pan, Yongxin; Yi, Liang; Zhu, Rixiang

    2015-04-01

    We have carried out an archaeomagnetic study on a late Neolithic locality (Liujiazhai) in Sichuan, southwestern China. We pull together various dating techniques, including radiocarbon analysis, optically stimulated luminescence dating, stratigraphic information as well as archaeological and archaeomagnetic estimations, to constrain the age of the studied samples. Rock magnetic results indicate thermally stable fine-grained magnetite or titanomagnetite as the dominant magnetic carriers. More than half of the specimens (141/246) in the paleointensity experiment pass the selection criteria and are considered to record robust intensity values. The virtual axial dipole moments range from approximately (2.8 to 7.8) × 1022 Am2 with an average of 5.9 × 1022 Am2, indicating that the geomagnetic intensity around 3000 before the Common Era (B.C.E.) is overall lower than the present field intensity (9.8 × 1022 Am2) of this area. The new results from Liujiazhai are generally consistent with the published data of similar age but deviate from the only available model of CALS10k.1b at certain time periods, making them important for future improvements of the model. Those data are significant for constraining the variation of geomagnetic field intensity between ~3100 and 2600 B.C.E. and improving the regional model of eastern Asia.

  1. Prenatal exposure to polychlorinated biphenyls and their hydroxylated metabolites is associated with neurological functioning in 3-month-old infants.

    PubMed

    Berghuis, Sietske A; Soechitram, Shalini D; Sauer, Pieter J J; Bos, Arend F

    2014-12-01

    Polychlorinated biphenyls (PCBs) are environmental chemicals which are potentially toxic to the developing brain. Their hydroxylated metabolites (OH-PCBs) are suggested to be even more toxic. Knowledge about the health effects of prenatal OH-PCB exposure is limited. We aimed to determine whether prenatal background exposure to PCBs and OH-PCBs is associated with neurological functioning in 3-month-old boys and girls. In a Dutch observational cohort study, we measured 10 PCBs and 6 OH-PCBs in maternal blood samples of 98 pregnant women. We assessed their infants neurologically with Touwen examination at 3 months and calculated an Optimality Score (OS, range 0-53, low-high optimality). We calculated correlation coefficients between compound levels and OS. Subsequently, we tested whether levels were associated with specific clusters and whether levels differed between infants with "normal" (dysfunction on ≤1 cluster) and "non-optimal" development (dysfunction on ≥2 clusters). The mean OS was 48 (range 44-52). Higher exposure to PCB-146 correlated significantly with higher OS (r = 0.209; p = 0.039). In boys, higher exposure to 4-OH-PCB-107 correlated with lower OS (r = -0.305; p = 0.030). Higher exposure to 9 PCBs and the sum of all PCBs was associated with better visuomotor and/or better sensorimotor function. Infants classified as "non-optimal" (n = 36) had significantly lower prenatal exposure to 6 PCBs and the sum of all PCBs (p < 0.05) compared with infants classified as "normal" (n = 62). In conclusion, higher prenatal exposure to Dutch background PCB levels is associated with better neurological functioning in 3-month-old infants. Prenatal exposure to 4-OH-PCB-107 is associated with less optimal neurological functioning in boys.

  2. Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE registry

    PubMed Central

    2013-01-01

    Background Patients with chronic obstructive pulmonary disease (COPD) have a modified clinical presentation of venous thromboembolism (VTE) but also a worse prognosis than non-COPD patients with VTE. As it may induce therapeutic modifications, we evaluated the influence of the initial VTE presentation on the 3-month outcomes in COPD patients. Methods COPD patients included in the on-going world-wide RIETE Registry were studied. The rate of pulmonary embolism (PE), major bleeding and death during the first 3 months in COPD patients were compared according to their initial clinical presentation (acute PE or deep vein thrombosis (DVT)). Results Of the 4036 COPD patients included, 2452 (61%; 95% CI: 59.2-62.3) initially presented with PE. PE as the first VTE recurrence occurred in 116 patients, major bleeding in 101 patients and mortality in 443 patients (Fatal PE: first cause of death). Multivariate analysis confirmed that presenting with PE was associated with higher risk of VTE recurrence as PE (OR, 2.04; 95% CI: 1.11-3.72) and higher risk of fatal PE (OR, 7.77; 95% CI: 2.92-15.7). Conclusions COPD patients presenting with PE have an increased risk for PE recurrences and fatal PE compared with those presenting with DVT alone. More efficient therapy is needed in this subtype of patients. PMID:23865769

  3. New EMA report on paliperidone 3-month injections: taking clinical and policy decisions without an adequate evidence base.

    PubMed

    Ostuzzi, G; Papola, D; Gastaldon, C; Barbui, C

    2016-12-22

    Three-month long-acting paliperidone is a new, recently marketed, formulation of paliperidone, characterised by the longest available dosing interval among long-acting antipsychotics. The clinical profile of 3-month long-acting paliperidone was recently summarised by the European Medicines Agency (EMA) in a public assessment report, released in April 2016. In this commentary, the main strengths and limitations of the EMA assessment report were appraised and discussed, in order to highlight possible implications for clinical practice, future research and regulatory practices for drug approval.

  4. Traumatic dissecting aneurysm at the vertebrobasilar junction in a 3-month-old infant: evaluation and treatment strategies. Case report.

    PubMed

    Wang, Huan; Orbach, Darren B

    2008-05-01

    Intracranial aneurysms in young infants are extremely rare, with few published reports on the etiology, evaluation, treatment strategies, and follow-up of this condition in this population. The authors report the case of a traumatic dissecting aneurysm at the vertebrobasilar junction (VBJ) in a 3-month-old infant caused by nonaccidental trauma. Therapeutic occlusion of the VBJ was contemplated, but coil embolization of the main aneurysm sac proved feasible, and anticoagulation and antiplatelet agents were initiated. The patient made a full neurological recovery, and follow-up studies demonstrated stable aneurysm occlusion. Management and follow-up strategies for this challenging condition are discussed.

  5. Microbiological and biochemical effectiveness of an antiseptic gel on the bacterial contamination of the inner space of dental implants: a 3-month human longitudinal study.

    PubMed

    D'Ercole, S; Tetè, S; Catamo, G; Sammartino, G; Femminella, B; Tripodi, D; Spoto, G; Paolantonio, M

    2009-01-01

    Microbial penetration inside the implants internal cavity produces a bacterial reservoir that is associated with an area of inflamed connective tissue facing the fixture-abutment junction. The aim of this clinical trial is to evaluate the effectiveness of a 1 percent chlorhexidine gel on the internal bacterial contamination of implants with screw-retained abutments and on the level of AST secreted in peri-implant crevicular fluid. Twenty-five patients (aged 29 to 58 years) each received one implant. Three months after the end of the restorative treatment, and immediately after a clinical and radiographic examination and the abutment removal, microbiological samples were obtained from the internal part of each fixture and biochemical samples were collected by peri-implant sulci. The patients were then divided into two groups: the control (CG; n=10) and test (TG; n=15) groups. The CG had the abutment screwed into place and the crown cemented without any further intervention. In contrast, before the abutment placement and screw tightening, the TG had the internal part of the fixture filled with a 1 percent chlorhexidine gel. Three months later, the same clinical, microbiological and biochemical procedures were repeated in both groups. Total bacterial count, specific pathogens and AST activity were detected. The clinical parameters remained stable throughout the study. From baseline to the 3-month examination, the total bacterial counts underwent a significant reduction only in the TG. In contrast, the AST activity showed a significant increase in the CG. The administration of a 1% chlorhexidine gel appears to be an effective method for the reduction of bacterial colonization of the implant cavity and for safeguarding the health status of peri-implant tissue over a 3-month administration period.

  6. [Tenth anniversary of smallpox eradication: Results of epidemiological and virological surveillance and studies in the post-eradication period].

    PubMed

    Marennikova, S S

    1989-06-01

    In accordance with recommendations of the Global Commission on the certification of smallpox eradication for the 10-year period after the eradication of this infection, all suspected cases of smallpox have been thoroughly checked up, and in none of them the diagnosis of smallpox has been confirmed. The study of monkeypox in humans has revealed that this zoonosis is spread over a wider area than supposed earlier and covers 7 countries of Equatorial Africa, occurring most frequently in Zaire. In about 70% of cases of monkeypox in human the disease is contracted from animals serving as natural virus carriers and in about one-third of such cases, from humans having monkeypox. The infectivity of humans with monkeypox for persons having close contacts with them is somewhat lower (12.3%) than in smallpox when this characteristic varies from 37% to 88%. Monkeypox in humans may take an asymptomatic course. Some species of tropical squirrels serve as natural virus carriers. These investigations have also resulted in essential corrections being made in understanding the ecology of cowpox virus, another orthopoxvirus pathogenic for man. At least 5 species of rodents have proved to be of interest as natural carriers of cowpox virus.

  7. Comparison of SAFER behavior assessment results in shelter dogs at intake and after a 3-day acclimation period.

    PubMed

    Bennett, Sara L; Weng, Hsin-Yi; Walker, Sheryl L; Placer, Margaret; Litster, Annette

    2015-01-01

    In this study, it was hypothesized that different results would be obtained by canine behavior assessments performed within 24 hr of shelter intake (Day 0) and after a 3-day acclimation period (Day 3). Safety Assessment for Evaluating Rehoming assessments were performed on 33 dogs at 2 municipal shelters. Agreements between Day 0 and Day 3 varied among subtests, and no consistent temporal patterns were observed. Weighted kappa statistics for each subtest ranged from .28 to .78, and percentage discordance was 0% to 18%. In a 2nd analysis, subtests skipped due to serious aggression were replaced with scores corresponding to serious aggression, and missing values for the Food subtest were replaced with scores for no aggression if the dog did not eat. For subtests skipped due to severe aggression, more than 50% of the dogs had scores indicating low aggression on the other assessment. Eight of 16 dogs who did not eat on Day 0 ate on Day 3; 2 showed aggression. Until the ideal time to test can be identified, it should be based on the individual dog's welfare status, and testing of dogs showing severe stress should be avoided.

  8. Effect of marginal maternal zinc intake on zinc absorption and growth of 3-month-old infant rhesus monkeys

    SciTech Connect

    Loennerdal, B.K.; Keen, C.L.; Bell, J.G.; Golub, M.S.; Hendrickx, A.G.; Gershwin, M.E. )

    1990-09-01

    One compensatory mechanism for marginal zinc intake may be through an enhanced absorption of zinc. Such a compensatory mechanism could be of value to the neonate, as poor zinc nutriture during early life has severe consequences on growth and development. We studied the uptake of zinc by 3-month-old infant rhesus monkeys born to dams fed control diets 100 micrograms of zinc per gram of diet or zinc-restricted diets (4 micrograms of zinc per gram of diet). Zinc uptake/retention was studied by feeding 3-month-old infant monkeys that had fasted an infant formula containing zinc 65 by gavage. Whole body radioactivity was counted immediately after intubation and on days 10 and 17 after intubation. Regardless of dietary group, 65-zinc retention was high, ranging from 33% to 71% of the dose fed to the monkeys. There were no significant differences between the two dietary groups in the percentage of zinc retention at days 10 and 17. Independent of the dietary group, there was no correlation between plasma zinc and zinc absorption. A positive correlation was found between weight gain and zinc retention in the marginal zinc infants, while a negative correlation between weight gain and zinc retention was observed in the control infants. These observations suggest that the mechanisms underlying growth may be different in infants born to dams fed control vs marginal zinc diets.

  9. 42 CFR 476.96 - Review period and reopening of initial denial determinations and changes as a result of DRG...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS UTILIZATION AND QUALITY CONTROL REVIEW Review Responsibilities of Utilization and Quality Control Quality Improvement Organizations (QIOs) Qio Review Functions § 476.96 Review period and reopening...

  10. Elementary school children's responses 3 months after the September 11 terrorist attacks: a study in Washington, DC.

    PubMed

    Phillips, Deborah; Prince, Shantay; Schiebelhut, Laura

    2004-10-01

    This study examined the responses of elementary school children in Washington, DC, to the September 11 terrorist attacks. Parents (primarily mothers) of children in kindergarten through Grade 6 and children in Grades 4 to 6, including 47 matched parent-child pairs, completed questionnaires regarding exposure, stress reactions, and constructive actions taken 3 months after the attacks. Parent reports and, to an even greater extent, children's self-reports revealed high levels of negative reactions to the attacks on behalf of the children. These reactions were best understood in the context of their exposure to the attacks, primarily through television news, and the reactions of and coping assistance provided by their parents. Implications for school personnel, health care professionals, and intervention efforts are discussed.

  11. Idiopathic bilateral chronic subdural hematoma with left internal carotid artery infarct in a 3 months infant: A rare case report

    PubMed Central

    Kumar, Mahesh; Yadav, Krishan; Verma, Saurabh Kumar; Maheshwari, Vikas

    2016-01-01

    Spontaneous chronic subdural hematoma (CSH) in infants is extremely rare. A very limited number of cases are known and reported in literature. The clinical presentation can be myriad varying from asymptomatic cases to gross neurological deficits. We report a case of a 3-month-old child who presented to us with repeated episodes of focal seizures of the left upper and lower limb of 1 month duration. Subsequent imaging revealed bilateral CSH (right > left) with left internal carotid artery infarct and midline shift to left by 8 mm. The child improved following burr hole evacuation of the right-sided CSH. The management of such case and a brief review of literature are discussed. PMID:28217168

  12. Changes in blood pressure, heart rate, and blood profile in mares during the last 3 months of gestation and the peripartum period.

    PubMed

    Nagel, Christina; Trenk, Lisa; Aurich, Jörg; Wulf, Manuela; Aurich, Christine

    2016-10-15

    In this study, peripartum changes in complete blood count, plasma electrolyte concentrations, blood pressure, heart rate, and heart rate variability (HRV) were determined in pregnant Warmblood mares (n = 10). Blood was collected from Days 245 to 330 of gestation (phase A), 2Days 3 to 1 before foaling (phase B), repeatedly within 12 hours after foaling (phase C), and on Days 1 to 3 postpartum (phase D). On the same days as blood collection, blood pressure and cardiac beat-to-beat intervals were measured and time domain HRV variables were calculated. Blood pressure decreased during the past 3 months of gestation, reached a nadir at foaling and increased rapidly thereafter (P < 0.001). Heart rate increased in phase A, reached a maximum in phase B, and decreased directly after foaling (P < 0.001) while HRV increased transiently after foaling (P < 0.001). The number of polymorphonuclear granulocytes was higher during phases B, C, and D than that during phase A (P < 0.001) and total leukocyte numbers peaked in phase C (P < 0.001). Erythrocyte counts and hematocrit increased immediately after foaling with a rapid decrease thereafter (P < 0.001), while plasma total protein was highest 1 hour after foaling (P < 0.001). Sodium and chloride concentrations increased from phases A to C and decreased in phase D (P < 0.001). Calcium concentrations were lowest immediately after foaling. In conclusion, changes in cardiovascular function and a transient hemoconcentration occur in peripartum mares. These changes may favor adequate uterine perfusion.

  13. Infants with complex congenital heart diseases show poor short-term memory in the mobile paradigm at 3 months of age.

    PubMed

    Chen, Chao-Ying; Harrison, Tondi; Heathcock, Jill

    2015-08-01

    The purpose of this study was to examine learning, short-term memory and general development including cognitive, motor, and language domains in infants with Complex Congenital Heart Defects (CCDH). Ten infants with CCHD (4 males, 6 females) and 14 infants with typical development (TD) were examined at 3 months of age. The mobile paradigm, where an infant's leg is tethered to an overhead mobile, was used to evaluate learning and short-term memory. The Bayley Scales of Infant Development 3rd edition (Bayley-III) was used to evaluate general development in cognitive, motor, and language domains. Infants with CCHD and infants with TD both showed learning with significant increase in kicking rate (p<0.001) across periods of the mobile paradigm, but only infants with TD demonstrated short-term memory (p=0.017) in the mobile paradigm. There were no differences on cognitive, motor, and language development between infants with CCHD and infants with TD on the Bayley-III. Early assessment is necessary to guide targeted treatment in infants with CCHD. One-time assessment may fail to detect potential cognitive impairments during early infancy in infants with CCHD. Supportive intervention programs for infants with CCHD that focuses on enhancing short-term memory are recommended.

  14. The impact of psychiatric disorders with cardiac syndrome X on quality of life: 3 months prospective study

    PubMed Central

    Altintas, Ebru; Yigit, Fatma; Taskintuna, Nilgun

    2014-01-01

    The aim of the study is to investigate the impact of psychiatric disorders with cardiac syndrome X (CSX) on the patients’ quality of life, as well as the efficacy of psychiatric support. Fifty-six CSX and fifty-three Coronary Heart Disease patients were included in the study after coronary angiography. Patients were evaluated right after the angiography and 3 months thereafter. The socio-demographic characteristics, comorbid disorders, Beck Anxiety (BAI), Depression (BDI) Inventory, and Health Related Quality of Life (SF-36) were compared between groups. The most common mental disorders was depression which account for 41%, the next were anxiety disorders (64%, n = 36) and somatoform (24%, n = 14). Initially, BAI, BDI in the CSX group were significantly higher when compared to the control group. There was significant difference in all subgroups of SF-36 at the end of the second evaluation versus the first evaluation in the CSX patients. The present study revealed that patients with CSX have higher prevalence of psychiatric comorbidities and lower quality of life. Psychiatric approaches are benefit for CSX patients to improvement their quality of life. PMID:25419392

  15. 42 CFR 476.96 - Review period and reopening of initial denial determinations and changes as a result of DRG...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... determinations and changes as a result of DRG validations. 476.96 Section 476.96 Public Health CENTERS FOR... initial denial determinations and changes as a result of DRG validations. (a) General timeframe. A QIO or... initial denial determination or a change as a result of a DRG validation. (b) Extended timeframes. (1)...

  16. A new result on the existence of periodic solutions for Liénard equations with a singularity of repulsive type.

    PubMed

    Lu, Shiping

    2017-01-01

    In this paper, the problem of the existence of a periodic solution is studied for the second order differential equation with a singularity of repulsive type [Formula: see text] where [Formula: see text] is singular at [Formula: see text], φ and h are T-periodic functions. By using the continuation theorem of Manásevich and Mawhin, a new result on the existence of positive periodic solution is obtained. It is interesting that the sign of the function [Formula: see text] is allowed to change for [Formula: see text].

  17. The HyMeX Special Observation Period in Central Italy: Precipitation Measurements, Retrieval Techniques and Preliminary Results

    NASA Technical Reports Server (NTRS)

    Gatlin, Patrick; Wingo, Matt; Petersen, Walt; Marzano, Frank Silvio; Baldini, Luca; Picciotti, Errico; Colantonio, Matteo; Barbieri, Stefano; Di Fabio, Saverio; Montopoli, Mario; Roberto, Nicoletta; Adirosi, Elisa; Gorgucci, Eugenio; Anagnostou, Emmanoil N..; Ferretti, Rossella

    2013-01-01

    The Mediterranean area concentrates the major natural risks related to the water cycle, including heavy precipitation and flash-flooding during the fall season. The capability to predict such high-impact events remains weak because of the contribution of very fine-scale processes and their non-linear interactions with the larger scale processes. These societal and science issues motivate the HyMeX (Hydrological cycle in the Mediterranean Experiment, http://www.hymex.orgl) experimental programme. HyMeX aims at a better quantification and understanding of the water cycle in the Mediterranean with emphasis on intense events. The observation strategy of HyMEX is organized in a long-term (4 years) Enhanced Observation Periods (EOP) and short-term (2 months) Special Observation Periods (SOP). HyMEX has identified 3 main Mediterranean target areas: North-West (NW), Adriatic (A) and South-East (SE). Within each target area several hydrometeorological sites for heavy rainfall and flash flooding have been set up. The hydrometeorological sire in Central Italy (CI) is interested by both western and eastern fronts coming from the Atlantic Ocean and Siberia, respectively. Orographic precipitations play an important role due to the central Apennine range, which reaches nearly 3000 m (Gran Sasso peak). Moreover, convective systems commonly develop in CI during late summer and beginning of autumn, often causing localized hailstorms with cluster organized cells. Western fronts may heavily hit the Tiber basin crossing large urban areas (Rome), whereas eastern fronts can cause flash floods along the Adriatic coastline. Two major basins are involved within Cl region: Tiber basin (1000 km long) and its tributary Aniene and the Aterno-Pescara basin (300 km long). The first HyMeX SOP1.1 was carried out from Sept. till Nov. 2012 in the NW target area The Italian SOP1.1 was coordinated by the Centre of Excellence CETEMPS, University of L'Aquila, a city located in the CI heart. The CI area

  18. Efficacy and Safety of Paliperidone Palmitate 3-Month Formulation for Patients with Schizophrenia: A Randomized, Multicenter, Double-Blind, Noninferiority Study

    PubMed Central

    Xu, Haiyan; Gopal, Srihari; Nuamah, Isaac; Ravenstijn, Paulien; Janik, Adam; Schotte, Alain; Hough, David; Fleischhacker, Wolfgang W.

    2016-01-01

    Background: This double-blind, parallel-group, multicenter, phase-3 study was designed to test the noninferiority of paliperidone palmitate 3-month formulation (PP3M) to the currently marketed 1-month formulation (PP1M) in patients (age 18–70 years) with schizophrenia, previously stabilized on PP1M. Methods: After screening (≤3 weeks) and a 17-week, flexible-dosed, open-label phase (PP1M: day 1 [150mg eq. deltoid], day 8 [100mg eq. deltoid.], weeks 5, 9, and 13 [50, 75, 100, or 150mg eq., deltoid/gluteal]), clinically stable patients were randomized (1:1) to PP3M (fixed-dose, 175, 263, 350, or 525mg eq. deltoid/gluteal) or PP1M (fixed-dose, 50, 75, 100, or 150mg eq. deltoid/gluteal) for a 48-week double-blind phase. Results: Overall, 1016/1429 open-label patients entered the double-blind phase (PP3M: n=504; PP1M: n=512) and 842 completed it (including patients with relapse). PP3M was noninferior to PP1M: relapse rates were similar in both groups (PP3M: n=37, 8%; PP1M: n=45, 9%; difference in relapse-free rate: 1.2% [95% CI:-2.7%; 5.1%]) based on Kaplan-Meier estimates (primary efficacy). Secondary endpoint results (changes from double-blind baseline in positive and negative symptom score total and subscale scores, Clinical Global Impression-Severity, and Personal and Social Performance scores) were consistent with primary endpoint results. No clinically relevant differences were observed in pharmacokinetic exposures between PP3M and PP1M. Both groups had similar tolerability profiles; increased weight was the most common treatment-emergent adverse event (double-blind phase; 21% each). No new safety signals were detected. Conclusion: Taken together, PP3M with its 3-month dosing interval is a unique option for relapse prevention in schizophrenia. PMID:26902950

  19. Results.

    ERIC Educational Resources Information Center

    Zemsky, Robert; Shaman, Susan; Shapiro, Daniel B.

    2001-01-01

    Describes the Collegiate Results Instrument (CRI), which measures a range of collegiate outcomes for alumni 6 years after graduation. The CRI was designed to target alumni from institutions across market segments and assess their values, abilities, work skills, occupations, and pursuit of lifelong learning. (EV)

  20. Periodic ordering of clusters and stripes in a two-dimensional lattice model. II. Results of Monte Carlo simulation

    NASA Astrophysics Data System (ADS)

    Almarza, N. G.; PÈ©kalski, J.; Ciach, A.

    2014-04-01

    The triangular lattice model with nearest-neighbor attraction and third-neighbor repulsion, introduced by Pȩkalski, Ciach, and Almarza [J. Chem. Phys. 140, 114701 (2014)] is studied by Monte Carlo simulation. Introduction of appropriate order parameters allowed us to construct a phase diagram, where different phases with patterns made of clusters, bubbles or stripes are thermodynamically stable. We observe, in particular, two distinct lamellar phases—the less ordered one with global orientational order and the more ordered one with both orientational and translational order. Our results concern spontaneous pattern formation on solid surfaces, fluid interfaces or membranes that is driven by competing interactions between adsorbing particles or molecules.

  1. Investigating Long-Range Dependence in American Treasury Bills Variations and Volatilities during Stable and Unstable Periods

    NASA Astrophysics Data System (ADS)

    Lahmiri, Salim

    2016-05-01

    Detrended fluctuation analysis (DFA) is used to examine long-range dependence in variations and volatilities of American treasury bills (TB) during periods of low and high movements in TB rates. Volatility series are estimated by generalized autoregressive conditional heteroskedasticity (GARCH) model under Gaussian, Student, and the generalized error distribution (GED) assumptions. The DFA-based Hurst exponents from 3-month, 6-month, and 1-year TB data indicates that in general the dynamics of the TB variations process is characterized by persistence during stable time period (before 2008 international financial crisis) and anti-persistence during unstable time period (post-2008 international financial crisis). For volatility series, it is found that; for stable period; 3-month volatility process is more likely random, 6-month volatility process is anti-persistent, and 1-year volatility process is persistent. For unstable period, estimation results show that the generating process is persistent for all maturities and for all distributional assumptions.

  2. Safety of purified decolorized (low anthraquinone) whole leaf Aloe vera (L) Burm. f. juice in a 3-month drinking water toxicity study in F344 rats.

    PubMed

    Shao, A; Broadmeadow, A; Goddard, G; Bejar, E; Frankos, V

    2013-07-01

    Decolorized (purified, low anthraquinone) whole leaf Aloe vera (L.) Burm. f. juice was administered at concentrations of 0%, 0.5%, 1% and 2% in the drinking water of F344Du rats for 3 months without any adverse effect. The no-observed-adverse-effect level (NOAEL) in this study was considered to be >2%w/v (>1845 mg/kg bodyweight/day for males and >2920 mg/kg bodyweight for females). The test material contained total anthraquinones at <0.1 parts per million. In the present study there was a complete absence of any histological alteration in samples from the cecum, colon (proximal, mid and distal regions). Similar concentrations of non-decolorized (unpurified, high anthraquinone) Aloe vera extracts tested in other studies have resulted in an increased incidence and severity of diarrhea and colon adenomas and carcinomas. The results of this study supports the assertion that the high levels of anthraquinone present in orally administered, non-purified whole leaf Aloe vera extract may be responsible for the adverse effects observed on the colon.

  3. Part 4. Effects of subchronic diesel engine emissions exposure on plasma markers in rodents: report on 1- and 3-month exposures in the ACES bioassay.

    PubMed

    Conklin, Daniel J; Kong, Maiying

    2012-09-01

    Although epidemiologic and experimental studies suggest that exposure to diesel exhaust (DE*) emissions causes adverse cardiovascular effects, neither the specific components of DE nor the mechanisms by which DE exposure could induce cardiovascular dysfunction and exacerbate cardiovascular disease (CVD) are known. Moreover, because the advance of new technologies has resulted in cleaner fuels and decreased engine emissions, there is even more uncertainty about the relationship between DE exposure and cardiovascular health effects. To address this ever-changing baseline of engine emissions, we tested for exposure-, sex- and duration-dependent alterations in plasma markers following subchronic exposure of mice and rats to DE emissions from a 2007-compliant diesel engine. Many plasma markers--several recognized as known human CVD risk factors--were measured in the plasma of rodents exposed to 1 or 3 months of air (the control) or DE emissions. Few changes in plasma markers resulted from exposure to DE, although significant exposure-level-dependent increases in total cholesterol and high-density lipoprotein (HDL) cholesterol were observed in male rats after 1 month of DE exposure, an effect that was neither sustained nor observed in any other group. These data indicate that DE emissions from a 2007-compliant diesel engine as tested in this study had little adverse effect on CVD markers in rodents.

  4. Factors associated with morbidity, mortality, and growth of dairy heifer calves up to 3 months of age.

    PubMed

    Windeyer, M C; Leslie, K E; Godden, S M; Hodgins, D C; Lissemore, K D; LeBlanc, S J

    2014-02-01

    Calfhood disease is an important problem on many dairy operations that can have substantial effects on heifer survival and productivity, and has economic and welfare impacts. Neonatal calf diarrhea (NCD) and bovine respiratory disease (BRD) are the most common causes of morbidity and mortality in young dairy cattle. The objective of this observational study was to investigate factors associated with the risks of morbidity and mortality, and with growth, in commercial dairy heifers calves. A total of 2874 heifer calves from 19 commercial dairy farms in Minnesota and Ontario were enrolled at 1-7 days of age and followed for approximately 3 months. Using cut-points of serum total protein of 5.2 and 5.7 g/dl, the incidences of failure of transfer of passive immunity (FTPI) were 11 and 32%, respectively. A cut-point of 5.7 g/dl was the most predictive of BRD before 5 weeks of age (sensitivity=40%, specificity=69%). The positive predictive value was poor (PPV=18%), but the negative predictive value was good (NPV=87%). A cut-point of 5.2g/dl was most predictive of death before 5 weeks of age (sensitivity=27%, specificity=89%, PPV=5%, NPV=98%). Serum total protein during the first week of life was a poor predictor of NCD. Over 23% of calves were treated for diarrhea. Risk factors were weight at enrollment, other diseases before 2 weeks of age, and an interaction between season of birth and herd-level incidence of NCD. Almost 22% of calves were treated at least once for BRD. Factors associated with an increased risk of BRD included herd-level incidence of BRD, season of birth, navel dipping, other diseases before 2 weeks of age, failure of transfer of passive immunity, and manual control of temperature in pre-weaning housing. Administration of supplemental antibody products at birth was associated with a reduced incidence of BRD. Overall mortality was 3.5%. Risk of mortality was increased by treatment for BRD and other diseases. The mean average weight gain was 0.95 kg

  5. Implementation of basic quality control tests for malaria medicines in Amazon Basin countries: results for the 2005–2010 period

    PubMed Central

    2012-01-01

    Background Ensuring the quality of malaria medicines is crucial in working toward malaria control and eventual elimination. Unlike other validated tests that can assess all critical quality attributes, which is the standard for determining the quality of medicines, basic tests are significantly less expensive, faster, and require less skilled labour; yet, these tests provide reproducible data and information on several critical quality attributes, such as identity, purity, content, and disintegration. Visual and physical inspection also provides valuable information about the manufacturing and the labelling of medicines, and in many cases this inspection is sufficient to detect counterfeit medicines. The Promoting the Quality of Medicines (PQM) programme has provided technical assistance to Amazon Malaria Initiative (AMI) countries to implement the use of basic tests as a key screening mechanism to assess the quality of malaria medicines available to patients in decentralized regions. Methods Trained personnel from the National Malaria Control Programmes (NMCPs), often in collaboration with country’s Official Medicine Control Laboratory (OMCL), developed country- specific protocols that encompassed sampling methods, sample analysis, and data reporting. Sampling sites were selected based on malaria burden, accessibility, and geographical location. Convenience sampling was performed and countries were recommended to store the sampled medicines under conditions that did not compromise their quality. Basic analytical tests, such as disintegration and thin layer chromatography (TLC), were performed utilizing a portable mini-laboratory. Results Results were originally presented at regional meetings in a non-standardized format that lacked relevant medicines information. However, since 2008 information has been submitted utilizing a template specifically developed by PQM for that purpose. From 2005 to 2010, the quality of 1,663 malaria medicines from seven AMI countries

  6. Incidence of Mastitis in the Neonatal Period in a Traditional Breastfeeding Society: Results of a Cohort Study

    PubMed Central

    Scott, Jane A.; Lee, Andy H.; Binns, Colin W.

    2015-01-01

    Abstract Background: Mastitis is a painful problem experienced by breastfeeding women, especially in the first few weeks postpartum. There have been limited studies of the incidence of mastitis from traditionally breastfeeding societies in South Asia. This study investigated the incidence, determinants, and management of mastitis in the first month postpartum, as well as its association with breastfeeding outcomes at 4 and 6 months postpartum, in western Nepal. Subjects and Methods: Subjects were a subsample of 338 mothers participating in a larger prospective cohort study conducted in 2014 in western Nepal. Mothers were interviewed during the first month postpartum and again at 4 and 6 months to obtain information on breastfeeding practices. The association of mastitis and determinant variables was investigated using multivariable logistic regression, and the association with breastfeeding duration was examined using Kaplan–Meier estimation. Results: The incidence of mastitis was 8.0% (95% confidence interval, 5.1%, 10.8%) in the first month postpartum. Prelacteal feeding (adjusted odds ratio = 2.76; 95% confidence interval, 1.03, 7.40) and cesarean section (adjusted odds ratio = 3.52; 95% confidence interval, 1.09, 11.42) were associated with a higher likelihood of mastitis. Kaplan–Meier estimation showed no significant difference in the duration of exclusive breastfeeding among the mothers who experienced an episode of mastitis and those who did not. Conclusions: Roughly one in 10 (8.0%) women experienced mastitis in the first month postpartum, and there appeared to be little effect of mastitis on breastfeeding outcomes. Traditional breastfeeding practices should be encouraged, and the management of mastitis should be included as a part of lactation promotion. PMID:26488802

  7. Oxalosis in primary hyperoxaluria in infancy : Report of a case in a 3-month-old baby. Follow-up for 3 years and review of literature.

    PubMed

    Orazi, Cinzia; Picca, Stefano; Schingo, Paolo M S; Fassari, Fausto M; Canepa, Giuseppe

    2009-04-01

    Primary hyperoxaluria (PH1) is a rare inborn autosomal recessive metabolic disorder due to the deficiency of hepatic alanine-glyoxylate-aminotransferase. This deficiency results in excessive synthesis and urinary excretion of oxalate, inducing renal stone formation and deposition of calcium oxalate in the kidney, bone, myocardium, and vessels (systemic oxalosis, SO) in the most severely affected individuals. We report renal and skeletal changes in a 3-month-old girl with PH1 and SO. Intense cortico-medullary hyperechogenicity and increased homogeneous radiopacity of normal-sized kidneys suggested the diagnosis of SO. Skeletal survey showed osteopenia and characteristic symmetrical metaphyseal transverse bands in long bones, progressively becoming more dense and migrating towards the diaphysis. Multiple pathological and slowly healing fractures of the limbs occurred at the dense band level. A radiopaque rim was then observed in flat bones, epiphyseal nuclei, and vertebral bodies. Inflammatory granulomatous reaction, induced by the presence of oxalate crystals in the marrow spaces, coexisted with progressively evident radiological signs of secondary hyperparathyroidism, with partially overlapping features. The patient was treated by peritoneal dialysis and hemodialysis until combined liver-kidney transplantation. There are no previous reports of infants treated with hemodialysis for more than 2 years.

  8. 20 CFR 404.1908 - Crediting foreign periods of coverage.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... assigned, or the reporting period ends. Example: Country XYZ, which has an annual reporting period... remaining fraction of 3 months, of coverage in a reporting period certified to SSA by the other country's agency. A reporting period used by a foreign country may be one calendar year or some other period...

  9. Groundwater-quality data in 12 GAMA study units: Results from the 2006–10 initial sampling period and the 2008–13 trend sampling period, California GAMA Priority Basin Project

    USGS Publications Warehouse

    Mathany, Timothy M.

    2017-03-09

    constituents (volatile organic compounds, pesticides, and pesticide degradates), constituents of special interest (perchlorate and 1,2,3-trichloropropane), and natural inorganic constituents (nutrients, major and minor ions, and trace elements). Isotopic tracers (tritium, carbon-14, and stable isotopes of hydrogen and oxygen in water) also were measured to help identify processes affecting groundwater quality and the sources and ages of the sampled groundwater. More than 200 constituents and water-quality indicators were measured during the trend sampling period.Quality-control samples (blanks, replicates, matrix-spikes, and surrogate compounds) were collected at about one-third of the trend sites, and the results for these samples were used to evaluate the quality of the data for the groundwater samples. On the basis of detections in laboratory and field blank samples collected by GAMA-PBP study units, including the 12 study units presented here, reporting levels for some groundwater results were adjusted in this report. Differences between replicate samples were mostly within acceptable ranges, indicating low variability in analytical results. Matrix-spike recoveries were largely within the acceptable range (70 to 130 percent).This study did not attempt to evaluate the quality of water delivered to consumers. After withdrawal, groundwater used for drinking water typically is treated, disinfected, and blended with other waters to achieve acceptable water quality. The comparison benchmarks used in this report apply to treated water that is served to the consumer, not to untreated groundwater. To provide some context for the results, however, concentrations of constituents measured in these groundwater samples were compared with benchmarks established by the U.S. Environmental Protection Agency and the State of California. Comparisons between data collected for this study and benchmarks for drinking water are for illustrative purposes only and are not indicative of compliance

  10. 46 CFR 169.226 - Periodic inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... periodic inspection within 3 months before or after the second or third anniversary of the date of your vessel's Certificate of Inspection. This periodic inspection will take the place of an annual inspection... a time and place which he or she approves. No written application is required. (c) The scope of...

  11. [Effect of 3-month exercise training on daily energy expenditure in formerly obese women with reduced and stable weight].

    PubMed

    Buemann, B; Astrup, A V

    1993-06-14

    Predisposition to obesity has been suggested to be related to a low energy expenditure (EE). This condition could be counteracted by physical exercise. In the present study we wanted to elucidate if aerob training could increase sedentary 24-hour energy expenditure in formerly obese subjects. Seven reduced-obese premenopausal women were studied in a respiration chamber before and after a three month period of aerobic training. No significant effects of training were seen on daytime, sleeping or total 24-hour EE. However, the change in daytime EE was positively correlated to the change in VO2max. Sleeping and 24-hour respiratory quotients were slightly increased after the training period. In order to reveal a possible role of the sympathetic nervous system in the observed effect of training, additional experiments were performed with beta blockade. However, no interactions between training and beta blockade were found.

  12. Diet and gender are important factors modulating low frequency EEG activity during processing of language sounds in 3 month old infants

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Little is known about how early postnatal diet affects brain processes related to cognitive function in healthy infants. To address this question we examined EEG activity recorded from 3 month old infants [breastfed (BF: n = 104, 55 males), milk-based formula fed (MF: n = 114, 57 males) or soy for...

  13. [Dental pain in the previous 3 months in adolescents and Family Health Strategy: the comparison between two areas with different to oralhealth care approaches].

    PubMed

    Carvalho, Jefferson Calixto; Rebelo, Maria Augusta Bessa; Vettore, Mario Vianna

    2011-10-01

    This study sought to compare the prevalence and intensity of dental pain in the last 3 months in adolescents living in two areas within the scope of Family Health Strategy with different to oralhealth care approaches. A cross-sectional study was conducted with 300 adolescents selected from public schools in the city of Manaus, Brazil. Adolescents living in an area with an Oral Health Team in which of health promotion is predominant (Group I, N = 150) were compared with those living in an area in which only dental treatment is offered (Group II, N = 150). Demographic and socio-economic characteristics, oral health-related behavior and use of dental services were gathered. Prevalence and intensity of dental pain in the last 3 months was assessed using a tested and validated Likert scale. The mean age of the participants was 12.9 ± 0.8 years, of which 46.7% were male. The prevalence of dental pain in the last 3 months was 33.7%, and did not differ between Groups I and II (P > 0.05). Medium to high intensity dental pain in the last 3 months was associated with Group II (OR: 2.11 [CI95 %=1.17-3.81]), after adjustment for covariates. Adolescents living in the area where only dental treatment is offered were more prone to severe dental pain compared to those living in the area where health programs are predominant.

  14. Fractional Erbium laser in the treatment of photoaging: randomized comparative, clinical and histopathological study of ablative (2940nm) vs. non-ablative (1540nm) methods after 3 months*

    PubMed Central

    Borges, Juliano; Cuzzi, Tullia; Mandarim-de-Lacerda, Carlos Alberto; Manela-Azulay, Mônica

    2014-01-01

    BACKGROUND Fractional non-ablative lasers keep the epidermis intact, while fractional ablative lasers remove it, making them theoretically more effective. OBJECTIVES To evaluate the clinical and histological alterations induced by fractional photothermolysis for treating photoaging, comparing the possible equivalence of multiple sessions of 1540nm Erbium, to one session of 2940nm Erbium. METHODS Eighteen patients (mean age 55.9) completed the treatment with three sessions of 1540nm fractional Erbium laser on one side of the face (50 mJ/mB, 15ms, 2 passes), and one session of 2940nm on the other side (5mJ/mB, 0.25ms, 2 passes). Biopsies were performed before and 3 months after treatment. Clinical, histological and morphometric evaluations were carried out. RESULTS All patients presented clinical improvement with no statistically significant difference (p> 0.05) between the treated sides. Histopathology revealed a new organization of collagen and elastic fibers, accompanied by edema, which was more evident with the 2940nm laser. This finding was confirmed by morphometry, which showed a decrease in collagen density for both treatments, with a statistical significance for the 2940nm laser (p > 0.001). CONCLUSIONS Three 1540nm sessions were clinically equivalent to one 2940nm session. The edema probably contributed to the positive results after three months, togheter with the new collagen and elastic fibers organization. The greater edema after the 2940nm session indicates that dermal remodeling takes longer than with 1540nm. It is possible that this histological superiority relates to a more prolonged effect, but a cohort longer than three months is needed to confirm that supposition. PMID:24770501

  15. The Impact of Patient Education on Anthropometric, Lipidemic, and Glycemic Parameters Among Patients With Poorly Controlled Type II Diabetes Mellitus: A 3-Month Prospective Single-Center Turkish Study.

    PubMed

    Cander, Soner; Gul, Ozen Oz; Gul, Cuma B; Keles, Saadet B; Yavas, Sibel; Ersoy, Canan

    2014-12-01

    This study evaluated the impact of patient education on adherence to a diabetes care plan (e.g., anthropometric, lipidemic, and glycemic parameters) among adults with type II diabetes mellitus without adequate glycemic control. A total of 61 ambulatory adults with type II diabetes mellitus (mean age: 53.6 ± 8.2 years, 70.5% female) were evaluated for anthropometrics, duration of diabetes mellitus, type of anti-diabetic treatment, blood biochemistry, and glycemic parameters in this 3-month prospective observational single-center study. During the course of the study, participants demonstrated a significant decrease in body weight and fat percentage and HbA1c (p < .001 for each). None of the factors evaluated was a significant determinant for glycemic parameters. These findings revealed that adults with type II diabetes mellitus who received education on adherence to routine self-monitoring of blood glucose, standard diabetic diet, and an exercise program delivered by certified diabetes educators had better glycemic control and significant decrease in body weight and fat percentage over a 3-month monitoring period.

  16. Usability, Participant Acceptance, and Safety of a Prefilled Insulin Injection Device in a 3-Month Observational Survey in Everyday Clinical Practice in Australia

    PubMed Central

    Carter, John; Beilin, Jonathan; Morton, Adam; De Luise, Mario

    2009-01-01

    Background SoloSTAR® (SOL; sanofi-aventis, Paris, France) is a prefilled insulin pen device for the injection of insulin glargine and insulin glulisine. This is the first Australian survey to determine its usability, participant acceptance, and safety in clinical practice. Methods A 3-month, nonrandomized, noncomparative, observational survey in Australia was conducted in individuals with diabetes. Participants were given SOL pens containing glargine, the instruction leaflet, and a toll-free helpline number. Training was offered to all participants. Safety data, including product technical complaints (PTCs), were gathered from ongoing feedback given by the participant or health care professional (HCP) and by independent interviews conducted 6–10 weeks after study start. Results Some 2674 people consented to take part across 93 sites (150 HCPs), and 2029 participated in interviews. Of these, 52.6% had type 1 diabetes, 16.3% had manual dexterity problems, and 15.5% had poor eyesight not corrected by glasses. At the time of interview, 96.8% of participants were still using SOL. None of the eight PTCs reported were due to technical defects; most were related to handling errors. Some 62 participants reported 77 adverse events; none were related to a PTC. The vast majority of participants (95.4%) were “very satisfied” or “satisfied” with using SOL, and 89.7% of the participants had no questions or concerns using SOL on a daily basis. Similar positive findings were reported by participants with manual or dexterity impairments. Conclusions In this survey of everyday clinical practice, SOL had a good safety profile and was very well accepted by participants. PMID:20144398

  17. Predictions of mortality from pleural mesothelioma in Italy: a model based on asbestos consumption figures supports results from age-period-cohort models.

    PubMed

    Marinaccio, Alessandro; Montanaro, Fabio; Mastrantonio, Marina; Uccelli, Raffaella; Altavista, Pierluigi; Nesti, Massimo; Costantini, Adele Seniori; Gorini, Giuseppe

    2005-05-20

    Italy was the second main asbestos producer in Europe, after the Soviet Union, until the end of the 1980s, and raw asbestos was imported on a large scale until 1992. The Italian pattern of asbestos consumption lags on average about 10 years behind the United States, Australia, the United Kingdom and the Nordic countries. Measures to reduce exposure were introduced in the mid-1970s in some workplaces. In 1986, limitations were imposed on the use of crocidolite and in 1992 asbestos was definitively banned. We have used primary pleural cancer mortality figures (1970-1999) to predict mortality from mesothelioma among Italian men in the next 30 years by age-cohort-period models and by a model based on asbestos consumption figures. The pleural cancer/mesothelioma ratio and mesothelioma misdiagnosis in the past were taken into account in the analysis. Estimated risks of birth cohorts born after 1945 decrease less quickly in Italy than in other Western countries. The findings predict a peak with about 800 mesothelioma annual deaths in the period 2012-2024. Results estimated using age-period-cohort models were similar to those obtained from the asbestos consumption model.

  18. A model study of the pollution effects of the first 3 months of the Holuhraun volcanic fissure: comparison with observations and air pollution effects

    NASA Astrophysics Data System (ADS)

    Steensen, Birthe Marie; Schulz, Michael; Theys, Nicolas; Fagerli, Hilde

    2016-08-01

    Norway, a region with frequent precipitation during westerly winds. Over a 3-month average (during SON 2014) over Europe, SO2 and PM2.5 surface concentrations, due to the volcanic emissions, increased by only ten and 6 % respectively. Although the percent increase of PM2.5 concentration is highest over Scandinavia and Scotland, an increase in PM exceedance days is found over Ireland and the already polluted Benelux region (up to 3 additional days), where any small increase in particulate matter concentration leads to an increase in exceedance days.

  19. Mother-infant interaction during the first 3 months: the emergence of culture-specific contingency patterns.

    PubMed

    Kärtner, Joscha; Keller, Heidi; Yovsi, Relindis D

    2010-01-01

    This study analyzed German and Nso mothers' auditory, proximal, and visual contingent responses to their infants' nondistress vocalizations in postnatal Weeks 4, 6, 8, 10, and 12. Visual contingency scores increased whereas proximal contingency scores decreased over time for the independent (German urban middle-class, N = 20) but not the interdependent sociocultural context (rural Nso farmers, N = 24). It seems, therefore, that culture-specific differences in the modal patterns of contingent responsiveness emerge during the 2nd and 3rd months of life. This differential development was interpreted as the result of the interplay between maturational processes associated with the 2-month shift that are selectively integrated and reinforced in culture-specific mother-infant interaction.

  20. Quasi-Periodic Oscillations and Frequencies in AN Accretion Disk and Comparison with the Numerical Results from Non-Rotating Black Hole Computed by the Grh Code

    NASA Astrophysics Data System (ADS)

    Donmez, Orhan

    The shocked wave created on the accretion disk after different physical phenomena (accretion flows with pressure gradients, star-disk interaction etc.) may be responsible observed Quasi Periodic Oscillations (QPOs) in X-ray binaries. We present the set of characteristics frequencies associated with accretion disk around the rotating and non-rotating black holes for one particle case. These persistent frequencies are results of the rotating pattern in an accretion disk. We compare the frequency's from two different numerical results for fluid flow around the non-rotating black hole with one particle case. The numerical results are taken from Refs. 1 and 2 using fully general relativistic hydrodynamical code with non-selfgravitating disk. While the first numerical result has a relativistic tori around the black hole, the second one includes one-armed spiral shock wave produced from star-disk interaction. Some physical modes presented in the QPOs can be excited in numerical simulation of relativistic tori and spiral waves on the accretion disk. The results of these different dynamical structures on the accretion disk responsible for QPOs are discussed in detail.

  1. A Web-Based Intervention for Users of Amphetamine-Type Stimulants: 3-Month Outcomes of a Randomized Controlled Trial

    PubMed Central

    McKetin, Rebecca; Kay-Lambkin, Frances; Carron-Arthur, Bradley; Bennett, Anthony; Bennett, Kylie; Christensen, Helen; Griffiths, Kathleen M

    2014-01-01

    Background Among illicit drugs, the prevalence of amphetamine-type stimulant (ATS) use is second only to cannabis. Currently, there are no approved pharmacotherapies for ATS problems, but some face-to-face psychotherapies are effective. Web-based interventions have proven to be effective for some substance use problems, but none has specifically targeted ATS users. Objective The objective of the study was to evaluate the effectiveness of a Web-based intervention for ATS problems on a free-to-access site compared with a waitlist control group. Methods We used a randomized controlled trial design. The primary outcome measure was self-reported ATS use in the past three months assessed using the Alcohol, Smoking, Substance Involvement Screening Test (ASSIST). Other measures included quality of life (EUROHIS score), psychological distress (K-10 score), days out of role, poly-drug use, general help-seeking intentions, actual help-seeking, and “readiness to change”. The intervention consisted of three fully automated, self-guided modules based on cognitive behavioral therapy and motivation enhancement. The analysis was an intention-to-treat analysis using generalized estimating equation models, with a group by time interaction as the critical assessment. Results We randomized 160 people (intervention n=81, control n=79). At three months, 35/81 (43%) intervention and 45/79 (57%) control participants provided follow-up data. In the intervention group, 51/81 (63%) completed at least one module. The only significant group by time interaction was for days out of role. The pre/post change effect sizes showed small changes (range d=0.14 to 0.40) favoring the intervention group for poly-drug use, distress, actual help-seeking, and days out of role. In contrast, the control group was favored by reductions in ATS use, improvements in quality of life, and increases in help-seeking intentions (range d=0.09 to 0.16). Conclusions This Web-based intervention for ATS use produced few

  2. Minimum Acceptable Diet at 9 Months but Not Exclusive Breastfeeding at 3 Months or Timely Complementary Feeding Initiation Is Predictive of Infant Growth in Rural Bangladesh

    PubMed Central

    Owais, Aatekah; Schwartz, Benjamin; Kleinbaum, David G.; Suchdev, Parminder S.; Faruque, A. S. G.; Das, Sumon K.; Stein, Aryeh D.

    2016-01-01

    The association between suboptimal infant feeding practices and growth faltering is well-established. However, most of this evidence comes from cross-sectional studies. To prospectively assess the association between suboptimal infant feeding practices and growth faltering, we interviewed pregnant women at 28–32 weeks’ gestation and followed-up their offspring at postnatal months 3, 9, 16 and 24 months in rural Bangladesh. Using maternal recall over the past 24 hours, exclusive breastfeeding (EBF) status at 3 months, age at complementary feeding (CF) initiation, and receipt of minimum acceptable diet (MAD; as defined by WHO) at 9 months were assessed. Infant length and weight measurements were used to produce length-for-age (LAZ) and weight-for-length (WLZ) z-scores at each follow-up. Generalized estimating equations were used to estimate associations of LAZ and WLZ with infant feeding practices. All models were adjusted for baseline SES, infant sex, maternal height, age, literacy and parity. Follow-up was completed by 2189, 2074, 1969 and 1885 mother-child dyads at 3, 9, 16 and 24 months, respectively. Stunting prevalence increased from 28% to 57% between infant age 3 and 24 months. EBF at 3 months and age at CF initiation were not associated with linear infant growth, but receipt of MAD at 9 months was. By age 24 months, infants receiving MAD had attained a higher LAZ compared to infants who did not receive MAD (adjusted β = 0.25, 95% CI: 0.13–0.37). Although prevalence of stunting was already high at age 3 months, ensuring infants receive a diverse, high quality diet from 6 months onwards may reduce rates of stunting in the second year of life. PMID:27776161

  3. Pulmonary haemosiderosis in a 13-year-old girl with coeliac disease after 3 months on a gluten-free diet: case report and review of the literature.

    PubMed

    Najada, A S; Dahabreh, M M

    2010-01-01

    A 13-year-old girl with controlled coeliac disease who had been on a gluten-free diet for the past 3 months was admitted with respiratory distress and hypoxia for the past week. Chest radiograph and CT scan showed bilateral widespread alveolar shadowing suggestive of a hypersensitive pneumonitis. There was a dramatic radiological and clinical response to oral corticosteroids. Bronchial lavage was suggestive of recurrent aspiration and histology of a transbronchial biopsy showed pulmonary haemosiderosis. We conclude that pulmonary haemosiderosis may occur in children with coeliac disease who are on a gluten-free diet.

  4. Clinical features and natural course of acromegaly in patients with discordance in the nadir GH level on the oral glucose test and the IGF-1 value at 3 months after adenomectomy.

    PubMed

    Kinoshita, Yasuyuki; Tominaga, Atsushi; Usui, Satoshi; Arita, Kazunori; Sakoguchi, Tetsuhiko; Sugiyama, Kazuhiko; Kurisu, Kaoru

    2016-04-01

    Discordant GH and IGF-1 levels after adenomectomy are well recognized in acromegalics. The aim of this study was to evaluate the clinical features and natural course of postoperative acromegaly associated with discordant GH and IGF-1 levels over a postoperative period. A total of 69 acromegalics underwent surgery with at least 1 year of follow-up and received 75-g oral glucose tolerance tests (OGTTs) at 3 months postoperatively. The patients were categorized into four groups according to the postoperative nadir GH levels and IGF-1 levels: controlled group (normal GH and normal IGF-1), high-IGF-1 group (normal GH and high IGF-1), high-GH group (high GH and normal IGF-1), and uncontrolled group (high GH and high IGF-1). The incidence of discordant GH and IGF-1 levels was 27.5%: high-IGF-1 group = 10.1% (n = 7) and high-GH group = 17.4% (n = 12). All patients in the high-IGF-1 group exhibited a decline in the IGF-1 level after surgery, with normalization observed in 71.4% of the patients without additional treatment (median 23 months). These subjects had preoperatively high IGF-1 levels despite not demonstrating higher GH levels than the patients in the controlled group. On the other hand, four patients in the high-GH group exhibited an elevated nadir GH level higher than 1.0 μg/L on repeated OGTTs after 3 months, and one patient experienced a recurrence of acromegaly. Patients in the high-IGF-1 group require no additional treatments, and their IGF-1 levels are likely to normalize within a few years. However, patients in the high-GH group should be carefully followed due to the possibility of recurrence.

  5. An experimental investigation of gapwise periodicity and unsteady aerodynamic response in an oscillating cascade. 1: Experimental and theoretical results. [turbine blades

    NASA Technical Reports Server (NTRS)

    Carta, F. O.

    1982-01-01

    Tests were conducted on a linear cascade of airfoils oscillating in pitch to measure the unsteady pressure response on selected blades along the leading edge plane of the cascade, over the chord of the center blade, and on the sidewall in the plane of the leading edge. The pressure data were reduced to Fourier coefficient form for direct comparison, and were also processed to yield integrated loads and, particularly, the aerodynamic damping coefficient. Results from the unsteady Verdon/Caspar theory for cascaded blades with nonzero thickness and camber were compared with the experimental measurements. The three primary results are: (1) from the leading edge plane blade data, the cascade was judged to be periodic in unsteady flow over the range of parameters tested; (2) the interblade phase angle was found to be the single most important parameter affecting the stability of the oscillating cascade blades; and (3) the real blade theory and the experiment were in excellent agreement for the several cases chosen for comparison.

  6. Blood Pressure and Metabolic Changes After 3-Month CPAP Therapy in a Very Elderly Obese with Severe Obstructive Sleep Apnea: A Case Report and Review of the Literature.

    PubMed

    Spannella, Francesco; Giulietti, Federico; Di Pentima, Chiara; Lombardi, Francesca Elena; Borioni, Elisabetta; Sarzani, Riccardo

    2017-03-21

    Age is one of the main risk factor for the presence of obstructive sleep apnea (OSA). This syndrome is associated with hypertension, cardiovascular disease, cognitive impairment and metabolic abnormalities, such as type 2 diabetes. Continuous positive airway pressure (CPAP) represents the gold standard therapy, but its benefit is still to be determined in very elderly. We report the blood pressure and metabolic changes in a very elderly obese with severe OSA after 3-month CPAP therapy. We have evaluated a very elderly obese male affected by severe symptomatic OSA, poor controlled nocturnal hypertension and insulin resistance. After 3-month CPAP therapy, without any changes in drug therapy, we observed a normalization of circadian blood pressure (BP) pattern, an improved insulin sensitivity, together with a reduced resting energy expenditure, despite no significant change in weight. This case report shows the benefits of OSA treatment with CPAP, not only on BP profile, but also on metabolic parameters in a very elderly, a particular type of patient in which scientific evidence is still scant. Further studies are needed to better investigate the relationship between OSA, CPAP therapy and energy expenditure not only in adults but also in elderly patients.

  7. Repeated, Intermittent Social Defeat across the Entire Juvenile Period Resulted in Behavioral, Physiological, Hormonal, Immunological, and Neurochemical Alterations in Young Adult Male Golden Hamsters.

    PubMed

    Yu, Wei-Chun; Liu, Ching-Yi; Lai, Wen-Sung

    2016-01-01

    The developing brain is vulnerable to social defeat during the juvenile period. As complements of human studies, animal models of social defeat provide a straightforward approach to investigating the functional and neurobiological consequences of social defeats. Taking advantage of agonist behavior and social defeat in male golden hamster, a set of 6 experiments was conducted to investigate the consequences at multiple levels in young adulthood resulting from repeated, intermittent social defeats or "social threats" across the entire juvenile period. Male hamsters at postnatal day 28 (P28) were randomly assigned to either the social defeat, "social threat", or arena control group, and they correspondingly received a series of nine social interaction trials (i.e., either social defeat, "social threat", or arena control conditions) from P33 to P66. At the behavioral level (Experiment 1), we found that repeated social defeats (but not "social threats") significantly impacted locomotor activity in the familiar context and social interaction in the familiar/unfamiliar social contexts. At the physiological and hormonal levels (Experiments 2 and 3), repeated social defeat significantly enhanced the cortisol and norepinephrine concentrations in blood. Enlargement of the spleen was also found in the social defeat and "social threat" groups. At the immunological level (Experiment 4), the social defeat group showed lower levels of pro-inflammatory cytokines in the hypothalamus and hippocampus but higher concentration of IL-6 in the striatum compared to the other two groups. At the neurochemical level (Experiment 5), the socially defeated hamsters mainly displayed reductions of dopamine, dopamine metabolites, and 5-HT levels in the striatum and decreased level of 5-HT in the hippocampus. In Experiment 6, an increase in the spine density of hippocampal CA1 pyramidal neurons was specifically observed in the "social threat" group. Collectively, our findings indicate that repeated

  8. Repeated, Intermittent Social Defeat across the Entire Juvenile Period Resulted in Behavioral, Physiological, Hormonal, Immunological, and Neurochemical Alterations in Young Adult Male Golden Hamsters

    PubMed Central

    Yu, Wei-Chun; Liu, Ching-Yi; Lai, Wen-Sung

    2016-01-01

    The developing brain is vulnerable to social defeat during the juvenile period. As complements of human studies, animal models of social defeat provide a straightforward approach to investigating the functional and neurobiological consequences of social defeats. Taking advantage of agonist behavior and social defeat in male golden hamster, a set of 6 experiments was conducted to investigate the consequences at multiple levels in young adulthood resulting from repeated, intermittent social defeats or “social threats” across the entire juvenile period. Male hamsters at postnatal day 28 (P28) were randomly assigned to either the social defeat, “social threat”, or arena control group, and they correspondingly received a series of nine social interaction trials (i.e., either social defeat, “social threat”, or arena control conditions) from P33 to P66. At the behavioral level (Experiment 1), we found that repeated social defeats (but not “social threats”) significantly impacted locomotor activity in the familiar context and social interaction in the familiar/unfamiliar social contexts. At the physiological and hormonal levels (Experiments 2 and 3), repeated social defeat significantly enhanced the cortisol and norepinephrine concentrations in blood. Enlargement of the spleen was also found in the social defeat and “social threat” groups. At the immunological level (Experiment 4), the social defeat group showed lower levels of pro-inflammatory cytokines in the hypothalamus and hippocampus but higher concentration of IL-6 in the striatum compared to the other two groups. At the neurochemical level (Experiment 5), the socially defeated hamsters mainly displayed reductions of dopamine, dopamine metabolites, and 5-HT levels in the striatum and decreased level of 5-HT in the hippocampus. In Experiment 6, an increase in the spine density of hippocampal CA1 pyramidal neurons was specifically observed in the “social threat” group. Collectively, our

  9. Measurement of the solar neutrino capture rate with gallium metal. III. Results for the 2002-2007 data-taking period

    NASA Astrophysics Data System (ADS)

    Abdurashitov, J. N.; Gavrin, V. N.; Gorbachev, V. V.; Gurkina, P. P.; Ibragimova, T. V.; Kalikhov, A. V.; Khairnasov, N. G.; Knodel, T. V.; Mirmov, I. N.; Shikhin, A. A.; Veretenkin, E. P.; Yants, V. E.; Zatsepin, G. T.; Bowles, T. J.; Elliott, S. R.; Teasdale, W. A.; Nico, J. S.; Cleveland, B. T.; Wilkerson, J. F.

    2009-07-01

    The Russian-American experiment SAGE began to measure the solar neutrino capture rate with a target of gallium metal in December 1989. Measurements have continued with only a few brief interruptions since that time. In this article we present the experimental improvements in SAGE since its last published data summary in December 2001. Assuming the solar neutrino production rate was constant during the period of data collection, combined analysis of 168 extractions through December 2007 gives a capture rate of solar neutrinos with energy more than 233 keV of 65.4-3.0+3.1 (stat) -2.8+2.6 (syst) SNU. The weighted average of the results of all three Ga solar neutrino experiments, SAGE, Gallex, and GNO, is now 66.1±3.1 SNU, where statistical and systematic uncertainties have been combined in quadrature. During the recent period of data collection a new test of SAGE was made with a reactor-produced Ar37 neutrino source. The ratio of observed to calculated rates in this experiment, combined with the measured rates in the three prior Cr51 neutrino-source experiments with Ga, is 0.87±0.05. A probable explanation for this low result is that the cross section for neutrino capture by the two lowest-lying excited states in Ge71 has been overestimated. If we assume these cross sections are zero, then the standard solar model including neutrino oscillations predicts a total capture rate in Ga in the range of 63 SNU to 66 SNU with an uncertainty of about 4%, in good agreement with experiment. We derive the current value of the neutrino flux produced in the Sun by the proton-proton fusion reaction to be ϕpp⊙=(6.0±0.8)×1010/(cm2s), which agrees well with the pp flux predicted by the standard solar model. Finally, we make several tests and show that the data are consistent with the assumption that the solar neutrino production rate is constant in time.

  10. Measurement of the solar neutrino capture rate with gallium metal. III. Results for the 2002-2007 data-taking period

    SciTech Connect

    Abdurashitov, J. N.; Gavrin, V. N.; Gorbachev, V. V.; Gurkina, P. P.; Ibragimova, T. V.; Kalikhov, A. V.; Khairnasov, N. G.; Knodel, T. V.; Mirmov, I. N.; Shikhin, A. A.; Veretenkin, E. P.; Yants, V. E.; Zatsepin, G. T.; Bowles, T. J.; Elliott, S. R.; Teasdale, W. A.; Nico, J. S.; Cleveland, B. T.; Wilkerson, J. F.

    2009-07-15

    The Russian-American experiment SAGE began to measure the solar neutrino capture rate with a target of gallium metal in December 1989. Measurements have continued with only a few brief interruptions since that time. In this article we present the experimental improvements in SAGE since its last published data summary in December 2001. Assuming the solar neutrino production rate was constant during the period of data collection, combined analysis of 168 extractions through December 2007 gives a capture rate of solar neutrinos with energy more than 233 keV of 65.4{sub -3.0}{sup +3.1} (stat) {sub -2.8}{sup +2.6} (syst) SNU. The weighted average of the results of all three Ga solar neutrino experiments, SAGE, Gallex, and GNO, is now 66.1{+-}3.1 SNU, where statistical and systematic uncertainties have been combined in quadrature. During the recent period of data collection a new test of SAGE was made with a reactor-produced {sup 37}Ar neutrino source. The ratio of observed to calculated rates in this experiment, combined with the measured rates in the three prior {sup 51}Cr neutrino-source experiments with Ga, is 0.87{+-}0.05. A probable explanation for this low result is that the cross section for neutrino capture by the two lowest-lying excited states in {sup 71}Ge has been overestimated. If we assume these cross sections are zero, then the standard solar model including neutrino oscillations predicts a total capture rate in Ga in the range of 63 SNU to 66 SNU with an uncertainty of about 4%, in good agreement with experiment. We derive the current value of the neutrino flux produced in the Sun by the proton-proton fusion reaction to be {phi}{sub pp}{sup {center_dot}}=(6.0{+-}0.8)x10{sup 10}/(cm{sup 2} s), which agrees well with the pp flux predicted by the standard solar model. Finally, we make several tests and show that the data are consistent with the assumption that the solar neutrino production rate is constant in time.

  11. Implementation of an Aerosol-Cloud Microphysics-Radiation Coupling into the NASA Unified WRF: Simulation Results for the 6-7 August 2006 AMMA Special Observing Period

    NASA Technical Reports Server (NTRS)

    Shi, J. J.; Matsui, T.; Tao, W.-K.; Tan, Q.; Peters-Lidard, C.; Chin, M.; Pickering, K.; Guy, N.; Lang, S.; Kemp, E. M.

    2014-01-01

    Aerosols affect the Earth's radiation balance directly and cloud microphysical processes indirectly via the activation of cloud condensation and ice nuclei. These two effects have often been considered separately and independently, hence the need to assess their combined impact given the differing nature of their effects on convective clouds. To study both effects, an aerosol-microphysics-radiation coupling, including Goddard microphysics and radiation schemes, was implemented into the NASA Unified Weather Research and Forecasting model (NU-WRF). Fully coupled NU-WRF simulations were conducted for a mesoscale convective system (MCS) that passed through the Niamey, Niger area on 6-7 August 2006 during an African Monsoon Multidisciplinary Analysis (AMMA) special observing period. The results suggest that rainfall is reduced when aerosol indirect effects are included, regardless of the aerosol direct effect. Daily mean radiation heating profiles in the area traversed by the MCS showed the aerosol (mainly mineral dust) direct effect had the largest impact near cloud tops just above 200 hectopascals where short-wave heating increased by about 0.8 Kelvin per day; the weakest long-wave cooling was at around 250 hectopascals. It was also found that more condensation and ice nuclei as a result of higher aerosol/dust concentrations led to increased amounts of all cloud hydrometeors because of the microphysical indirect effect, and the radiation direct effect acts to reduce precipitating cloud particles (rain, snow and graupel) in the middle and lower cloud layers while increasing the non-precipitating particles (ice) in the cirrus anvil. However, when the aerosol direct effect was activated, regardless of the indirect effect, the onset of MCS precipitation was delayed about 2 hours, in conjunction with the delay in the activation of cloud condensation and ice nuclei. Overall, for this particular environment, model set-up and physics configuration, the effect of aerosol

  12. CONSTRAINTS ON LONG-PERIOD PLANETS FROM AN L'- AND M-BAND SURVEY OF NEARBY SUN-LIKE STARS: MODELING RESULTS

    SciTech Connect

    Heinze, A. N.; Hinz, Philip M.; Kenworthy, Matthew; Sivanandam, Suresh; Miller, Douglas; Meyer, Michael E-mail: phinz@as.arizona.ed E-mail: suresh@as.arizona.ed E-mail: mmeyer@phys.ethz.c

    2010-05-10

    We have carried out an L'- and M-band adaptive optics (AO) extrasolar planet imaging survey of 54 nearby, Sun-like stars using the Clio camera at the MMT. Our survey concentrates more strongly than all others to date on very nearby F, G, and K stars, in that we have prioritized proximity higher than youth. Our survey is also the first to include extensive observations in the M band, which supplemented the primary L' observations. These longer-wavelength bands are most useful for very nearby systems in which low-temperature planets with red IR colors (i.e., H - L', H - M) could be detected. The survey detected no planets, but set interesting limits on planets and brown dwarfs in the star systems we investigated. We have interpreted our null result by means of extensive Monte Carlo simulations and constrained the distributions of extrasolar planets in mass M and semimajor axis a. If planets are distributed according to a power law with dN {proportional_to} M {sup {alpha}} a {sup {beta}} dMda, normalized to be consistent with radial velocity (RV) statistics, we find that a distribution with {alpha} = -1.1 and {beta} = -0.46, truncated at 110 AU, is ruled out at the 90% confidence level. These particular values of {alpha} and {beta} are significant because they represent the most planet-rich case consistent with current statistics from RV observations. With 90% confidence no more than 8.1% of stars like those in our survey have systems with three widely spaced, massive planets like the A star HR 8799. Our observations show that giant planets in long-period orbits around Sun-like stars are rare, confirming the results of shorter-wavelength surveys and increasing the robustness of the conclusion.

  13. Changes in Maternal Plasma Adiponectin from Late Pregnancy to the Postpartum Period According to the Mode of Delivery: Results from a Prospective Cohort in Rio de Janeiro, Brazil

    PubMed Central

    Rebelo, Fernanda; Franco-Sena, Ana Beatriz; Struchiner, Claudio Jose; Kac, Gilberto

    2016-01-01

    Introduction Maternal plasma adiponectin is inversely related to insulin resistance, atherosclerosis and child health. However, little is known about its concentrations in the perinatal period, especially according to mode of delivery. Our aim is to evaluate the association between mode of delivery and changes in maternal plasma adiponectin from 3rd trimester of pregnancy to 30–45 days postpartum. Methods A cohort was recruited in Rio de Janeiro, Brazil, with four waves of follow-up: 5-13th, 22-26th, 30-36th gestational weeks and 30–45 days postpartum. Eligible subjects should be between 20–40 years of age, be free of chronic and infectious diseases and presenting with a singleton pregnancy. The mode of delivery was classified as vaginal (VD) or cesarean (CS). Plasma adiponectin concentration (μg/mL) was measured using commercial ELISA kits. Statistical analyses included the Wilcoxon rank-sum test and the multiple linear mixed effects model. Results A total of 159 participated in the study. Median adiponectin concentrations were higher for the VD group (n = 99; 8.25, IQR: 5.85–11.90) than for the CS group (n = 60; 7.34, IQR: 4.36–9.76; p = 0.040) in the postpartum samples but were not different between the two groups in the 3rd trimester. Women who underwent CS had a lower rate of increase in adiponectin concentration from the 3rd trimester to 30–45 days postpartum compared to those who underwent VD (β = -.15, 95% CI: -.28-.02, p = 0.030). Conclusion The CS procedure was associated with lower maternal circulating concentrations of adiponectin at 30–45 days postpartum, compared to the VD. PMID:27391647

  14. Debridement with prosthesis retention and antibiotherapy vs. two-stage revision for periprosthetic knee infection within 3 months after arthroplasty: a case-control study.

    PubMed

    Lizaur-Utrilla, A; Gonzalez-Parreño, S; Gil-Guillen, V; Lopez-Prats, F A

    2015-09-01

    Sixty-four patients with periprosthetic infection within 3 months of index arthroplasty, of whom 39 underwent debridement with prosthesis retention and antibiotherapy (DPRA), and 25 underwent two-stage revision (2SR), were compared regarding control of infection and functional outcomes by use of Knee Society scores. Failure was defined as the need for subsequent surgery to control infection. The failure rate after DPRA was 61.5%, and that after 2SR was 12.0% (p 0.001). The failure risk was not significantly associated with the duration of symptoms (≤4 weeks). The only predictor of failure was isolation of Staphylococcus aureus or Staphylococcus epidermidis. Treatment with 2SR required fewer surgical operations, a shorter duration of hospitalization, and a shorter duration of treatment. All patients who required a second debridement ultimately underwent prosthesis removal. The functional outcome was significantly better for 2SR at the last follow-up.

  15. Bilateral Leg Replantation in a 3-Month-Old Baby After a Knee Level Crush Amputation-A 2-Year Follow-up.

    PubMed

    Bulic, Kresimir; Antabak, Anko; Dujmovic, Anto; Kisic, Hrvoje; Lorencin, Mia

    2017-03-01

    We present a case of a successful bilateral leg replantation in a 3-month-old baby after a knee-level crush amputation with the loss of both knee joints. The legs were replanted after 4 hours of warm and an additional 2.5 and 3.5 hours of cold ischemia time. Both legs show motor and sensory reinnervation, without additional procedures performed on the right leg, and after a nerve reconstruction with cadaveric allografts on the left leg. Both replanted legs exhibit excellent bony and soft tissue growth. Two years after the injury, the patient is progressing well with rehabilitation, with favourable odds of having knee reconstructions performed at a later age. This is the youngest patient reported to have had successful replantation of both legs.

  16. Dosing and Switching Strategies for Paliperidone Palmitate 3-Month Formulation in Patients with Schizophrenia Based on Population Pharmacokinetic Modeling and Simulation, and Clinical Trial Data.

    PubMed

    Magnusson, Mats O; Samtani, Mahesh N; Plan, Elodie L; Jonsson, E Niclas; Rossenu, Stefaan; Vermeulen, An; Russu, Alberto

    2017-04-01

    Paliperidone palmitate 3-month formulation (PP3M), a long-acting injectable atypical antipsychotic, was recently approved in the US and Europe for the treatment of schizophrenia in adult patients who have already been treated with paliperidone palmitate 1-month formulation (PP1M) for ≥4 months. This article reviews the pharmacokinetic rationale for the approved dosing regimens for PP3M, dosing windows, management of missed doses and treatment discontinuation, switching to other formulations, and dosing in special populations. Approved PP3M dosing regimens are based on the comparisons of simulations with predefined dosing regimens using paliperidone palmitate and oral paliperidone extended release (ER) population pharmacokinetic models (one-compartment model with two saturable absorption processes for PP3M; one-compartment model with parallel zero- and first-order absorption for PP1M; two-compartment model with sequential zero- and first-order absorption for ER) versus clinical trial data. Covariates were obtained by resampling subject covariates from the pharmacokinetics database for PP1M and PP3M. Simulation scenarios with varying doses and covariate values were generated. The population median and 90% prediction interval of the simulated concentration-time profiles were plotted for simulation outcomes evaluation. Simulations described in this paper provide (a) simulated plasma exposures for switching from PP1M to PP3M, (b) support for a once-every-3-months injection cycle, (c) information on dosing windows and managing missed doses of PP3M, (d) important guidance on PP3M dosing in special patient populations, and (e) key PP3M pharmacokinetic exposure metrics based on the population pharmacokinetic PP3M model. Population pharmacokinetics provided practical guidance to establish dosing regimens for PP3M.

  17. 46 CFR 189.27-5 - Periodic inspection.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... periodic inspection within 3 months before or after the second or third anniversary of the date of your vessel's Certificate of Inspection. This periodic inspection will take the place of an annual inspection. (b) You must contact the cognizant OCMI to schedule an inspection at a time and place which he or...

  18. New results to discuss possibility of irrigation in Bat (Wadi Sharsah, northwestern Oman) before Hafit period (ca. 3100-2700 BCE)

    NASA Astrophysics Data System (ADS)

    Fouache, Eric; Desruelles, Stéphane; Eddargach, Wassel; Cammas, Cecilia; Wattez, Julia; Martin, Chloé; Tengberg, Margareta; Beuzen-Waller, Tara; Cable, Charlotte; Thornton, Christopher

    2014-05-01

    Registered as a World Heritage Site by UNESCO in 1989, the extensive archaeological site of Bat is situated within the Wadi Sharsah and around the modern village and palm grove of Bat, 24 km from the modern city of Ibri in northwestern Oman. The archaeological remains from the Bronze Age excavated by the Bat Archaeological Project are located in two mains areas. The northern area consists of a chain of low limestone hills cut by wadi tributaries leading to the main Wadi Sharsah. It is characterised by an exceptionnally high density of graves from two successive Bronze Age periods : Hafit (ca. 3100-2700 BCE) and Umm an-Nar (ca. 2700-2000 BCE). South of the Bat cemetery, in the flat part of the valley, there are several large circular structures (known historically as « towers ») and remains from both Hafit and Umm an-Nar periods, as well as later periods. Geomorphological mapping of the floodplain, associated with archaeological survey, have identified walls suggesting that during the Umm an-Nar period there was a system of irrigation which controlled flood water. Sedimentological, malacological, C14 dating and micromorphological studies of a 10 m long and 2.5 m high section located 143 m northeast of the Tower 1146 on the left bank of a small tributary of the Wadi Sharsah provide strong argument for the presence of an irrigation system that began before the Hafit period. New C14 datings confirm this hypothesis. Botanical macro-remains collected during the excavation of early Bronze Age structures at Bat further indicate the presence of date palm gardens since the 3rd millenium BCE allowing the cultivation of several crop species, in particular cereals. Most generally the global palaeoenvironmental reconstruction from our data supports a model of a general trend of aridification from Bronze Age to iron Age. Key words : Bronze Age, Holocene, Geomoephology, Micromorphology, Irrigation, Oman.

  19. Part 3. Assessment of genotoxicity and oxidative stress after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: report on 1- and 3-month exposures in the ACES bioassay.

    PubMed

    Hallberg, L M; Ward, J B; Hernandez, C; Ameredes, B T; Wickliffe, J K

    2012-09-01

    -exposed animals. Results from the comet assay showed no significant differences in rats between the control and exposed groups (P = 0.53, low exposure; P = 0.92, medium exposure; P = 0.77, high exposure) after 1 month of DE exposure. There were no differences between sexes in the responses of rats to these exposures. Likewise, there were no significant differences found after 3 months of exposure. Similarly, no significant differences were found between the mice exposed for 1 and 3 months to DE, nor were any differences found between sexes. Measurements of 8-OHdG in both mice and rats showed no significant difference among DE exposure groups (P = 0.46, mice; P = 0.86, rats). In mice, measured 8-OHdG was lower in the 3-month group than the 1-month group. In rats, the inverse was true. In mice, no significant differences in the levels of lipid peroxidation, as measured by TBARS, were found between the controls and DE exposure groups (P = 0.92), nor were there any differences between sexes. In rats, comparisons between the control and low-exposure groups approached significance, but no significant differences were found between the other DE exposure groups. Additionally, in rats, there were no significant differences between the 1- and 3-month DE exposure groups.

  20. [Cessation of fluoridation of drinking water; results of caries research in Tiel and Culemborg in the period of 1968-1988].

    PubMed

    Kalsbeek, H; Kwant, G W; Groeneveld, A; Backer Dirks, O; van Eck, A A; Theuns, H M

    1992-01-01

    In December 1973 water fluoridation was discontinued in Tiel, the Netherlands. Six years later an epidemiological study was started, with the aim to investigate the consequences. In the period from 1979 to 1988 a yearly caries investigation was carried out in 15 year old children born and living in Tiel and children living in the control town of Culemborg, where the drinking water had never been fluoridated. The 15 year old children in 1979-1980 in Tiel had a 18% higher caries experience than the same age group in 1968-1969, to whom fluoridated water had been available from birth onward. In the same period a 28% decrease of the caries was found in Culemborg. In 1979-1980 the DMFS-index in Tiel was still 36% lower than in Culemborg. Between 1979-1980 and 1987-1988 the caries experience decreased in both towns.

  1. Periodic parallel array of nanopillars and nanoholes resulting from colloidal stripes patterned by geometrically confined evaporative self-assembly for unique anisotropic wetting.

    PubMed

    Li, Xiangmeng; Wang, Chunhui; Shao, Jinyou; Ding, Yucheng; Tian, Hongmiao; Li, Xiangming; Wang, Li

    2014-11-26

    In this paper we present an economical process to create anisotropic microtextures based on periodic parallel stripes of monolayer silica nanoparticles (NPs) patterned by geometrically confined evaporative self-assembly (GCESA). In the GCESA process, a straight meniscus of a colloidal dispersion is initially formed in an opened enclosure, which is composed of two parallel plates bounded by a U-shaped spacer sidewall on three sides with an evaporating outlet on the fourth side. Lateral evaporation of the colloidal dispersion leads to periodic "stick-slip" receding of the meniscus (evaporative front), as triggered by the "coffee-ring" effect, promoting the assembly of silica NPs into periodic parallel stripes. The morphology of stripes can be well controlled by tailoring process variables such as substrate wettability, NP concentration, temperature, and gap height, etc. Furthermore, arrayed patterns of nanopillars or nanoholes are generated on a silicon wafer using the as-prepared colloidal stripes as an etching mask or template. Such arrayed patterns can reveal unique anisotropic wetting properties, which have a large contact angle hysteresis viewing from both the parallel and perpendicular directions in addition to a large wetting anisotropy.

  2. Irregular Periods

    MedlinePlus

    ... number of days after the last one. The Menstrual Cycle Most girls get their first period between the ... to skip periods or to have an irregular menstrual cycle. Illness, rapid weight change, or stress can also ...

  3. Organic micro-pollutants in a karst system during low and high flow periods, results of a two-year study

    NASA Astrophysics Data System (ADS)

    Reh, Roland; Licha, Tobias; Geyer, Tobias; Nödler, Karsten; Sauter, Martin

    2013-04-01

    and desethylatrazine, indicates limited aquifer connections and demonstrates a residence time of several years for vertical transport into the deep aquifer. Phenazone originates also from a disused waste disposal and is showing a persistency for more than three decades under the observed redox conditions. References Nödler K, Licha T, Bester K, Sauter M. Development of a multi-residue analytical method, based on liquid chromatography-tandem mass spectrometry, for the simultaneous determination of 46 micro-contaminants in aqueous samples. Journal of Chromatography A 2010;1217(42), 6511-6521. Reh R, Licha T, Geyer T, Nödler, K.,Sauter M. Occurrence and spatial distribution of organic micro-pollutants in a complex hydrogeological karst system during low flow and high flow periods, results of a two-year study. Science of The Total Environment 2013, 443,438-445, 10.1016/j.scitotenv.2012.11.005.

  4. Prevalence and risk factors of posttraumatic stress disorder among teachers 3 months after the Lushan earthquake: A cross-sectional study.

    PubMed

    Zhang, Jun; Zhang, Ye; Du, Changhui; Zhu, Shenyue; Huang, Yalin; Tian, Yulian; Chen, Decao; Li, Haimin; Gong, Yao; Zhang, Mengmeng; Gu, Bo

    2016-07-01

    Teachers and students often suffer from the same disaster. The prevalence of PTSD in students has been given great attention. However, in acting as mentors to students and their families, teachers are more likely to have vicarious and indirect exposure via hearing stories of their aftermath and witnessing the consequences of traumatic events. There are limited data pertaining to the prevalence of PTSD and its risk factors among teachers. A total of 316 teachers from 21 primary and secondary schools in Baoxing County were administered a project-developed questionnaire which included the items regarding demographic characteristics, earthquake-related experiences, somatic discomforts, emotional reactions, support status, and everyday functioning 2 weeks after the Lushan earthquake, and they finished a 1-to-1 telephone interview for addressing the PTSD criteria of the Mini International Neuropsychiatric Interview (MINI) 3 months after the earthquake. The prevalence of PTSD was 24.4% among teachers. Somatic discomforts (odds ratio [OR] 1.89, 95% confidence interval [CI] 1.06-3.37) were positive risk factors of PTSD. Perceived social support (OR 0.30, 95% CI 0.14-0.62) and being able to calm down (OR 0.25, 95% CI 0.09-0.75) in teaching were negative risk factors. PTSD is commonly seen among teachers after an earthquake, and risk factors of PTSD were identified. These findings may help those providing psychological health programs to find the teachers who are at high risk of PTSD in schools after an earthquake in China.

  5. Effects of functional movement strength training on strength, muscle size, kinematics, and motor function in cerebral palsy: a 3-month follow-up.

    PubMed

    Lee, Jung Ah; You, Joshua H; Kim, Dong A; Lee, Min Jin; Hwang, Pil Woo; Lee, Nam Gi; Park, Jeong Joon; Lee, Dong Ryul; Kim, Hyun-Kyung

    2013-01-01

    We investigated the long-term effects of comprehensive hand repetitive intensive strengthening training (CHRIST) on strength, morphological muscle size, kinematics, and associated motor functional changes in children with cerebral palsy (CP). Ten children (5 boys, 5 girls; age range, 6-11 years, mean age, 8.6 years) participated in the study. The children were classified according to the Manual Ability Classification System: 5 were Level II, 2 were Level III, and 3 were Level IV. Quantitative biomechanical measurements were performed to determine muscle strength, muscle size, kinematics (normalized jerk score), and motor function using a dynamometer, ultrasound, Vicon motion analysis, and standardized clinical tests (Quality of Upper Extremity Skills Test, Jebsen-Taylor Hand Function Test, Functional Independence Measure, and Pediatric Motor Activity Log), respectively. Muscle strength, muscle size, kinematics, and motor function significantly improved after a 10-week intervention (3 times a week), and the long-term effects remained even at the 3-month follow-up. In conclusion, this is the first study highlighting the long-term efficacy of upper extremity strength training using the novel CHRIST system in children with CP, which will potentially open up new horizons for effective management in pediatric neurorehabilitation.

  6. Masses of long-period comets derived from non-gravitational effects - analysis of the computed results and the consistency and reliability of the non-gravitational parameters

    NASA Astrophysics Data System (ADS)

    Sosa, Andrea; Fernández, Julio A.

    2011-09-01

    We estimate masses for a selected sample of long-period comets (LPCs) (with orbital periods P > 1000 yr and perihelion distances q < 2 au), with good photometric visual light curves and known non-gravitational parameters. We follow a procedure similar to that developed by Szutowicz et al. to estimate the masses of comets C/1995 O1 (Hale-Bopp) and C/1996 B2 (Hyakutake). The method also requires the knowledge of the water production rates Q, for which we find a new correlation between Q and the visual total heliocentric magnitude mh of LPCs, which can be expressed as log10Q= 30.53 - 0.234mh. The computed masses are in the range [0.5, 10]× 1012 kg. From these masses, and by assuming a cometary bulk density ρ of 0.4 g cm-3, we estimate the effective nuclear radii RN for the studied LPCs to be in the range [0.7, 1.8] km. From the computed values of RN, we find that the active surface areas are (in most cases) greater than the geometric ones (fractions f ranging from 0.8 to 2.4). We argue that this could be understood as a state of hyperactivity, which can be explained if a significant fraction of the sublimated water molecules come from the sublimation of icy grains in the coma. Hyperactivity would make LPC nuclei smaller (i.e. less massive) than expected from their coma brightness. Other effects, like extremely low densities or overestimated non-gravitational parameters, might also contribute to the rather high computed value of f. For comet C/1995 O1 (Hale-Bopp), we find a seeming inconsistency between some size estimates and some computed non-gravitational parameters. We analyse some alternatives to this apparent paradox. We also compute absolute total magnitudes and photometric indices for the studied sample of LPCs and find a new correlation between masses and absolute total visual magnitudes H. By assuming ρ= 0.4 g cm-3, we can convert masses to diameters D, leading to a relation log10D(km) = 1.5 - 0.13H.

  7. Laser-induced interstitial thermotherapy (LITT) for treatment of uterine leiomyomas: 750 myomas were treated by LITT and the results over a five-year period are analyzed

    NASA Astrophysics Data System (ADS)

    Chapman, Roxana

    1997-05-01

    Approximately 750 leiomyomas of 250 symptomatic patients were treated by LITT over a five-year period. Only 12% were lost to follow-up. Most were treated by a combination of the KTP/YAG laser, rarely by one or the other alone, and a few with the diode laser. The fiber optic was inserted 2 cm apart and, depending on the size of the tumor, 480 - 20,000 Joules were required. Most were treated laparoscopically but very large myomas were treated percutaneously under ultrasound control. Symptoms were nearly always relieved and the six failures were found to be due to unrecognized adenomyosis and other associated pathology. Half the patients complaining of infertility became pregnant and, in those whose only pathology had been leiomyomas it approached 90%. Vaginal delivery was not found to be contraindicated. Finally, oestrogen receptors and epidermal growth factor were found to be destroyed. It is concluded that LITT enables leiomyomas of all sizes and locations to be treated by a minimally invasive method with preservation of the uterus.

  8. Part 2. Assessment of genotoxicity after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: report on 1- and 3-month exposures in the ACES bioassay.

    PubMed

    Bemis, Jeffrey C; Torous, Dorothea K; Dertinger, Stephen D

    2012-09-01

    genotoxicity. Statistical approaches employed analysis of variance (ANOVA) to compare effects of sex, exposure condition, and duration, as well as their interactions. This initial assessment of MN was performed on both mouse and rat blood samples from the 1-month and 3-month exposures. The data from mice demonstrate the well established, sex-based difference in MN-RET and MN-NCE frequencies regularly observed in this species, with females exhibiting slightly lower frequencies. There were no sex-based differences observed in rats. An examination of the mean frequencies across the exposure groups and durations of exposure did not show an appreciable induction of MN at the 1- or 3-month exposures in either species. Further statistical analyses did not reveal any significant exposure-related effects. An examination of the potential genotoxic effects of DE is clearly valuable as part of a large-scale chronic-exposure bioassay. The data and observations from the 1-and 3-month exposure studies will eventually be combined with the results from the 1- and 2-year exposure studies to provide a comprehensive examination of chronic exposure to DE in a rodent model. This examination of chromosome damage serves an important role in the context of the entire ACES bioassay, which was designed to assess the safety of diesel combustion engines.

  9. Evolution of periodicity in periodical cicadas.

    PubMed

    Ito, Hiromu; Kakishima, Satoshi; Uehara, Takashi; Morita, Satoru; Koyama, Takuya; Sota, Teiji; Cooley, John R; Yoshimura, Jin

    2015-09-14

    Periodical cicadas (Magicicada spp.) in the USA are famous for their unique prime-numbered life cycles of 13 and 17 years and their nearly perfectly synchronized mass emergences. Because almost all known species of cicada are non-periodical, periodicity is assumed to be a derived state. A leading hypothesis for the evolution of periodicity in Magicicada implicates the decline in average temperature during glacial periods. During the evolution of periodicity, the determinant of maturation in ancestral cicadas is hypothesized to have switched from size dependence to time (period) dependence. The selection for the prime-numbered cycles should have taken place only after the fixation of periodicity. Here, we build an individual-based model of cicadas under conditions of climatic cooling to explore the fixation of periodicity. In our model, under cold environments, extremely long juvenile stages lead to extremely low adult densities, limiting mating opportunities and favouring the evolution of synchronized emergence. Our results indicate that these changes, which were triggered by glacial cooling, could have led to the fixation of periodicity in the non-periodical ancestors.

  10. Evolution of periodicity in periodical cicadas

    PubMed Central

    Ito, Hiromu; Kakishima, Satoshi; Uehara, Takashi; Morita, Satoru; Koyama, Takuya; Sota, Teiji; Cooley, John R.; Yoshimura, Jin

    2015-01-01

    Periodical cicadas (Magicicada spp.) in the USA are famous for their unique prime-numbered life cycles of 13 and 17 years and their nearly perfectly synchronized mass emergences. Because almost all known species of cicada are non-periodical, periodicity is assumed to be a derived state. A leading hypothesis for the evolution of periodicity in Magicicada implicates the decline in average temperature during glacial periods. During the evolution of periodicity, the determinant of maturation in ancestral cicadas is hypothesized to have switched from size dependence to time (period) dependence. The selection for the prime-numbered cycles should have taken place only after the fixation of periodicity. Here, we build an individual-based model of cicadas under conditions of climatic cooling to explore the fixation of periodicity. In our model, under cold environments, extremely long juvenile stages lead to extremely low adult densities, limiting mating opportunities and favouring the evolution of synchronized emergence. Our results indicate that these changes, which were triggered by glacial cooling, could have led to the fixation of periodicity in the non-periodical ancestors. PMID:26365061

  11. Utilization of Research Results in the Building Industry. A State of the Art Survey. Final Report for Period October 1972-June 1974.

    ERIC Educational Resources Information Center

    Wilson, Duncan M.

    A problem in the building industry is the lack of coordination of research efforts and the time lag between the completion of research and the incorporation of the results in practice. A partial solution is attempted in this survey of current and past research dealing with innovation and other problems in the building industry and related…

  12. Period Pain

    MedlinePlus

    ... You may also have other symptoms, such as lower back pain, nausea, diarrhea, and headaches. Period pain is not ... Taking a hot bath Doing relaxation techniques, including yoga and meditation You might also try taking over- ...

  13. Periodized wavelets

    SciTech Connect

    Schlossnagle, G.; Restrepo, J.M.; Leaf, G.K.

    1993-12-01

    The properties of periodized Daubechies wavelets on [0,1] are detailed and contrasted against their counterparts which form a basis for L{sup 2}(R). Numerical examples illustrate the analytical estimates for convergence and demonstrate by comparison with Fourier spectral methods the superiority of wavelet projection methods for approximations. The analytical solution to inner products of periodized wavelets and their derivatives, which are known as connection coefficients, is presented, and several tabulated values are included.

  14. Prenatal and early postnatal intoxication by inorganic mercury resulting from the maternal use of mercury containing soap.

    PubMed

    Lauwerys, R; Bonnier, C; Evrard, P; Gennart, J P; Bernard, A

    1987-05-01

    A case of slight renal tubular dysfunction associated with cataract and anaemia was diagnosed in a 3-month-old black boy in whom high levels of mercury were found in blood and urine. Several arguments suggest that the renal, ocular and haematological defects may have resulted from exposure to mercury during foetal life and the 1-month lactation period due to the extensive use of inorganic mercury containing cosmetics by the mother.

  15. How do long-term development and periodical changes of river-floodplain systems affect the fate of contaminants? Results from European rivers.

    PubMed

    Lair, G J; Zehetner, F; Fiebig, M; Gerzabek, M H; van Gestel, C A M; Hein, T; Hohensinner, S; Hsu, P; Jones, K C; Jordan, G; Koelmans, A A; Poot, A; Slijkerman, D M E; Totsche, K U; Bondar-Kunze, E; Barth, J A C

    2009-12-01

    In many densely populated areas, riverine floodplains have been strongly impacted and degraded by river channelization and flood protection dikes. Floodplains act as buffers for flood water and as filters for nutrients and pollutants carried with river water and sediment from upstream source areas. Based on results of the EU-funded "AquaTerra" project (2004-2009), we analyze changes in the dynamics of European river-floodplain systems over different temporal scales and assess their effects on contaminant behaviour and ecosystem functioning. We find that human-induced changes in the hydrologic regime of rivers have direct and severe consequences on nutrient cycling and contaminant retention in adjacent floodplains. We point out the complex interactions of contaminants with nutrient availability and other physico-chemical characteristics (pH, organic matter) in determining ecotoxicity and habitat quality, and draw conclusions for improved floodplain management.

  16. Results of a search for daily and annual variations of the 214Po half-life at the two year observation period

    NASA Astrophysics Data System (ADS)

    Alexeyev, E. N.; Gavrilyuk, Yu. M.; Gangapshev, A. M.; Kazalov, V. V.; Kuzminov, V. V.; Panasenko, S. I.; Ratkevich, S. S.

    2016-11-01

    The brief description of installation TAU-2 intended for long-term monitoring of the half-life value τ( T 1/2) of the 214Po is presented. The methods of measurement and processing of collected data are reported. The results of analysis of time series values of τ with different time step are presented. Total measurement time was equal to 590 days. Averaged value of the 214Po half-life was obtained τ = 163.46 ± 0.04 μs. The annual variation with an amplitude A = (8.9 ± 2.3) × 10-4, solar-daily variation with an amplitude A So = (7.5 ± 1.2) × 10-4, lunar-daily variation with an amplitude A L = (6.9 ± 2.0) × 10-4 sidereal-daily variation with an amplitude A S = (7.2 ± 1.2) × 10-4 were found in a series of τ values. The maximal values of amplitude are observed at the moments when the projections of the installation Earth location velocity vectors toward the source of possible variation achieve its maximal magnitudes.

  17. Financial Results during Periods of Inflation.

    ERIC Educational Resources Information Center

    Thompson, James W.; Anderson, Richard E.

    1983-01-01

    The effects of inflation on the operations of 10 northeastern colleges and universities and the effect of using current cost accounting are considered. The focus is on adjustments to assets in the plant fund by restating the surplus and deficit calculations of four state and six private institutions. The 10 institutions had plant assets with an…

  18. Periodic Polymers

    NASA Astrophysics Data System (ADS)

    Thomas, Edwin

    2013-03-01

    Periodic polymers can be made by self assembly, directed self assembly and by photolithography. Such materials provide a versatile platform for 1, 2 and 3D periodic nano-micro scale composites with either dielectric or impedance contrast or both, and these can serve for example, as photonic and or phononic crystals for electromagnetic and elastic waves as well as mechanical frames/trusses. Compared to electromagnetic waves, elastic waves are both less complex (longitudinal modes in fluids) and more complex (longitudinal, transverse in-plane and transverse out-of-plane modes in solids). Engineering of the dispersion relation between wave frequency w and wave vector, k enables the opening of band gaps in the density of modes and detailed shaping of w(k). Band gaps can be opened by Bragg scattering, anti-crossing of bands and discrete shape resonances. Current interest is in our group focuses using design - modeling, fabrication and measurement of polymer-based periodic materials for applications as tunable optics and control of phonon flow. Several examples will be described including the design of structures for multispectral band gaps for elastic waves to alter the phonon density of states, the creation of block polymer and bicontinuous metal-carbon nanoframes for structures that are robust against ballistic projectiles and quasi-crystalline solid/fluid structures that can steer shock waves.

  19. Complementary Effects of Genetic Variations in LEPR on Body Composition and Soluble Leptin Receptor Concentration after 3-Month Lifestyle Intervention in Prepubertal Obese Children

    PubMed Central

    Gajewska, Joanna; Kuryłowicz, Alina; Mierzejewska, Ewa; Ambroszkiewicz, Jadwiga; Chełchowska, Magdalena; Weker, Halina; Puzianowska-Kuźnicka, Monika

    2016-01-01

    In obese individuals, weight loss might be affected by variants of the adipokine-encoding genes. We verified whether selected functional single nucleotide polymorphisms in LEP, LEPR and ADIPOQ are associated with changes in serum levels of the respective adipokines and weight loss in 100 prepubertal obese (SDS-BMI > 2) Caucasian children undergoing lifestyle intervention. Frequencies of the -2548G > A LEP, Q223R LEPR, K656N LEPR, -11377C > G and -11426A > G ADIPOQ polymorphisms were analyzed by restriction fragment length polymorphism. Serum adipokine and soluble leptin receptor (sOB-R) concentrations were measured using the ELISA method. Among the analyzed polymorphisms, only LEPR polymorphisms were associated with changes of SDS-BMI or sOB-R concentrations in children after therapy. Carriers of the wild-type K665N and at least one minor Q223R allele had the greatest likelihood of losing weight (OR = 5.09, p = 0.006), an increase in sOB-R (ptrend = 0.022) and decrease in SDS-BMI correlated with the decrease of fat mass (p < 0.001). In contrast, carrying of the wild-type Q223R and at least one minor K665N allele were associated with a decrease in sOB-R concentrations and a decrease in SDS-BMI correlated with a decrease in fat-free mass (p = 0.002). We suggest that the combination of different LEPR variants, not a single variant, might determine predisposition to weight loss in the prepubertal period. PMID:27240401

  20. Irregular Periods

    MedlinePlus

    ... may develop problems as a result of a hormone imbalance. For example, disorders of the thyroid gland can cause menstrual irregularities if the levels of thyroid hormone in the blood become too low or too ...

  1. Serotonin Transporter Gene ("SLC6A4") Methylation Associates with Neonatal Intensive Care Unit Stay and 3-month-old Temperament in Preterm Infants

    ERIC Educational Resources Information Center

    Montirosso, Rosario; Provenzi, Livio; Fumagalli, Monica; Sirgiovanni, Ida; Giorda, Roberto; Pozzoli, Uberto; Beri, Silvana; Menozzi, Giorgia; Tronick, Ed; Morandi, Francesco; Mosca, Fabio; Borgatti, Renato

    2016-01-01

    Preterm birth and Neonatal Intensive Care Unit (NICU) stay are early adverse stressful experiences, which may result in an altered temperamental profile. The serotonin transporter gene ("SLC6A4"), which has been linked to infant temperament, is susceptible to epigenetic regulation associated with early stressful experience. This study…

  2. Gene Therapy Rescues Cone Structure and Function in the 3-Month-Old rd12 Mouse: A Model for Midcourse RPE65 Leber Congenital Amaurosis

    PubMed Central

    Li, Xia; Li, Wensheng; Dai, Xufeng; Kong, Fansheng; Zheng, Qinxiang; Zhou, Xiangtian; Lü, Fan; Chang, Bo; Rohrer, Bärbel; Hauswirth, William. W.; Qu, Jia; Pang, Ji-jing

    2011-01-01

    Purpose. RPE65 function is necessary in the retinal pigment epithelium (RPE) to generate chromophore for all opsins. Its absence results in vision loss and rapid cone degeneration. Recent Leber congenital amaurosis type 2 (LCA with RPE65 mutations) phase I clinical trials demonstrated restoration of vision on RPE65 gene transfer into RPE cells overlying cones. In the rd12 mouse, a naturally occurring model of RPE65-LCA early cone degeneration was observed; however, some peripheral M-cones remained. A prior study showed that AAV-mediated RPE65 expression can prevent early cone degeneration. The present study was conducted to test whether the remaining cones in older rd12 mice can be rescued. Methods. Subretinal treatment with the scAAV5-smCBA-hRPE65 vector was initiated at postnatal day (P)14 and P90. After 2 months, electroretinograms were recorded, and cone morphology was analyzed by using cone-specific peanut agglutinin and cone opsin–specific antibodies. Results. Cone degeneration started centrally and spread ventrally, with cells losing cone-opsin staining before that for the PNA-lectin–positive cone sheath. Gene therapy starting at P14 resulted in almost wild-type M- and S-cone function and morphology. Delaying gene-replacement rescued the remaining M-cones, and most important, more M-cone opsin–positive cells were identified than were present at the onset of gene therapy, suggesting that opsin expression could be reinitiated in cells with cone sheaths. Conclusions. The results support and extend those of the previous study that gene therapy can stop early cone degeneration, and, more important, they provide proof that delayed treatment can restore the function and morphology of the remaining cones. These results have important implications for the ongoing LCA2 clinical trials. PMID:21169527

  3. Radiosynoviorthesis in hemophilic joints with yttrium-90 citrate and rhenium-186 sulfide and long term results.

    PubMed

    Teyssler, Petr; Taborska, Katerina; Kolostova, Katarina; Bobek, Vladimir

    2013-01-01

    Repeated bleeding in the joint cavities is the most annoying symptom and often has disabling effects in patients with hemophilia (PWH). Our aim was to study the effect of radiosynovectomy (RSO) with beta particle-emitting radiocolloids in the treatment of hemorhagic arthropathy. We have treated 22 joints from 18 patients with hemophilia A, from April 2008 to February 2012, 5 knees, 11 elbows and 6 ankles. Joints were divided into two Groups, those treated with yttrium-90-citrate ((90)Y-C) (5 knees, 2 of them twice)-Group I and those with rhenium-186-sulfide ((186)Re-S) (11 elbows, 1 of them treated twice and 6 ankles)-Group II. A total of 25 treatments. Follow-up period was 3 months, 1 year and 3 years. Results showed a favourable subjective and a better objective result in all 5 joints of Group I and in 15/17 joints of Group II, respectively. Follow-up after 3 months showed significant improvement in Hemophilia Join Health Score (HJHS) after 20 treatments and steady score after 5 treatments. After 1 year, 19 treated joints had improved for the first time, 3 remained steady and 3 were not examined. After 3 years, 9 treated joints were HJHS steady, while 16 were not examined. One year after treatment, 13/14 joints of patients, aged 6-23 years showed better HJHS score, while 9/11 joints of patients aged 26-51 years, showed better HJHS. Synovial membrane thickness as measured by MRI in 8 joints, before and 3 months after treatment was not related to prognosis. In conclusion, in a small group of hemophilic patients with hemorrhagic arthropathy treated with (90)Y-C and with (186)Re-S, our study showed good results irrespective of age in 22/25 treatments after 3 months or 1 year. The thickness of synovial membrane in the 8 joints studied was not related to prognosis.

  4. Setting the Periodic Table.

    ERIC Educational Resources Information Center

    Saturnelli, Annette

    1985-01-01

    Examines problems resulting from different forms of the periodic table, indicating that New York State schools use a form reflecting the International Union of Pure and Applied Chemistry's 1984 recommendations. Other formats used and reasons for standardization are discussed. (DH)

  5. Parent Spirituality, Grief, and Mental Health at 1 and 3 Months After Their Infant's/Child's Death in an Intensive Care Unit

    PubMed Central

    Hawthorne, Dawn M.; Youngblut, JoAnne M.; Brooten, Dorothy

    2016-01-01

    Problem The death of an infant/child is one of the most devastating experiences for parents and immediately throws them into crisis. Research on the use of spiritual/religious coping strategies is limited, especially with Black and Hispanic parents after a neonatal (NICU) or pediatric intensive care unit (PICU) death. Purpose The purpose of this longitudinal study was to test the relationships between spiritual/religious coping strategies and grief, mental health (depression and post-traumatic stress disorder) and personal growth for mothers and fathers at 1 (T1) and 3 (T2) months after the infant's/child's death in the NICU/ PICU, with and without control for race/ethnicity and religion. Results Bereaved parents' greater use of spiritual activities was associated with lower symptoms of grief, mental health (depression and post-traumatic stress), but not post-traumatic stress in fathers. Use of religious activities was significantly related to greater personal growth for mothers, but not fathers. Conclusion Spiritual strategies and activities helped parents cope with their grief and helped bereaved mothers maintain their mental health and experience personal growth. PMID:26320884

  6. Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series

    PubMed Central

    2011-01-01

    Background Serotonin reuptake inhibitors (SRIs) currently represent the cornerstone of obsessive-compulsive disorder (OCD) pharmacotherapy. However, OCD is characterized by high rates of partial and/or absent response to standard, recommended treatments, often prompting pharmacological and non-pharmacological augmentation or switching of strategies. Agomelatine, a novel melatonin agonist and selective serotonin antagonist (MASSA) antidepressant approved for major depressive disorder (MDD) has recently been additionally proposed as a treatment for anxiety disorders such as social anxiety disorder (SAD) and panic disorder (PD), but not yet OCD. Nonetheless, agomelatine may have a role in the management of OCD, essentially due to its anxiolytic 5-hydroxytryptamine (HT)2C blockade action, while melatonin (MT)1 and MT2 modulation might contribute to circadian rhythm restoration if impaired. Methods This case series reports the outcome of six patients with or without comorbid mood and/or other anxiety disorders who were treated with SRIs at adequate doses for at least 8 weeks, showing partial or no response. Patients were then switched to agomelatine 50 mg/day, and followed up for 12 weeks. Results Three out of six patients, in particular those with relevant circadian rhythm subjective impairment, showed a Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score reduction of ≥35%. No relevant side effects were observed, but initial, transient, self-remitting dizziness in one patient and weight gain in another were seen. Conclusions Although clinical confounding factors (subthreshold bipolarity and eventually the presence of impaired circadian rhythms) and methodological boundaries (lack of control and neurophysiological recording, tiny sample size and short follow-up) limit the validity of this preliminary observation, it does indicate agomelatine may have a role in some SRI-refractory OCD cases, thus prompting the validity of investigation by further controlled studies

  7. Home care by general practitioners for cancer patients in the last 3 months of life: An epidemiological study of quality and associated factors

    PubMed Central

    Pivodic, Lara; Harding, Richard; Calanzani, Natalia; McCrone, Paul; Hall, Sue; Deliens, Luc; Higginson, Irene J; Gomes, Barbara

    2016-01-01

    Background: Stronger generalist end-of-life care at home for people with cancer is called for but the quality of end-of-life care delivered by general practitioners has been questioned. Aim: To determine the degree of and factors associated with bereaved relatives’ satisfaction with home end-of-life care delivered by general practitioners to cancer patients. Design: Population-based mortality followback survey. Setting/participants: Bereaved relatives of people who died of cancer in London, United Kingdom (identified from death registrations in 2009–2010), were invited to complete a postal questionnaire surveying the deceased’s final 3 months of life. Results: Questionnaires were completed for 596 decedents of whom 548 spent at least 1 day at home in the last 3 months of life. Of the respondents, 55% (95% confidence interval: 51%–59%) reported excellent/very good home care by general practitioners, compared with 78% (95% confidence interval: 74%–82%) for specialist palliative care providers and 68% (95% confidence interval: 64%–73%) for district/community/private nurses. The odds of high satisfaction (excellent/very good) with end-of-life care by general practitioners doubled if general practitioners made three or more compared with one or no home visits in the patient’s last 3 months of life (adjusted odds ratio: 2.54 (95% confidence interval: 1.52–4.24)) and halved if the patient died at hospital rather than at home (adjusted odds ratio: 0.55 (95% confidence interval: 0.31–0.998)). Conclusion: There is considerable room for improvement in the satisfaction with home care provided by general practitioners to terminally ill cancer patients. Ensuring an adequate offer of home visits by general practitioners may help to achieve this goal. PMID:26036688

  8. Breastfeeding Status at Age 3 Months Is Associated with Adiposity and Cardiometabolic Markers at Age 4 Years in Mexican Children123

    PubMed Central

    Ramirez-Silva, Ivonne; Rivera, Juan A; Trejo-Valdivia, Belem; Martorell, Reynaldo; Stein, Aryeh D; Romieu, Isabelle; Barraza-Villarreal, Albino; Ramakrishnan, Usha

    2015-01-01

    Background: The effect of breastfeeding (BF) on cardiometabolic risk factors is not well characterized. Objective: The objective was to assess the association of BF status at 3 mo and duration with adiposity and cardiometabolic markers at 4 y. Methods: We studied 727 children with prospectively collected BF information and anthropometric measurements at 4 y, of whom 524 provided a nonfasting blood sample. BF status at 3 mo was classified as exclusive or predominant (EBF-PreBF), partial (PaBF), or nonbreastfeeding (NBF). Total duration of any BF was classified as <3 mo, 3– 6 mo, >6 to 12 mo, and >12 mo. We modeled associations of BF with body mass index (BMI; in kg/m2), serum total cholesterol and low-density lipoprotein (LDL) cholesterol, triglycerides (TGs), and insulin at 4 y. Results: Children who were NBF or PaBF at 3 mo had higher BMI [0.46 (95% CI: 0.16, 0.76) and 0.31 (95% CI: 0.07, 0.54), respectively] than the EBF-PreBF group (P < 0.01). NBF children had higher total cholesterol (8.02 mg/dL; 95% CI: 1.39, 14.64; P = 0.02) than children who were EBF-PreBF. LDL cholesterol (5.04 mg/dL; 95% CI: −0.72, 10.81) and TGs (12% change; 95% CI: −0.01, 0.24) showed similar patterns. An inverse association between EBF-PreBF and insulin, mediated through abdominal circumference, was documented (P < 0.05). Children breastfed <3 mo had higher BMI (0.44; 95% CI: 0.11, 0.77) at 4 y than children breastfed for >12 mo. Conclusion: EBF and PreBF at 3 mo were associated with lower adiposity and serum total cholesterol in children at 4 y. In addition, BF >12 mo was associated with lower adiposity. These data confirm the importance of exclusive BF and prolonged BF for later cardiometabolic health. PMID:25926414

  9. Genealogy of periodic trajectories

    SciTech Connect

    de Adguiar, M.A.M.; Maldta, C.P.; de Passos, E.J.V.

    1986-05-20

    The periodic solutions of non-integrable classical Hamiltonian systems with two degrees of freedom are numerically investigated. Curves of periodic families are given in plots of energy vs. period. Results are presented for this Hamiltonian: H = 1/2(p/sub x//sup 2/ + p/sub y//sup 2/) + 1/2 x/sup 2/ + 3/2 y/sup 2/ - x/sup 2/y + 1/12 x/sup 4/. Properties of the families of curves are pointed out. (LEW)

  10. Reference ranges for cortisol and α-amylase in mother and newborn saliva samples at different perinatal and postnatal periods.

    PubMed

    García-Blanco, Ana; Vento, Máximo; Diago, Vicente; Cháfer-Pericás, Consuelo

    2016-06-01

    This paper describes a reliable analytical method based on Ultra High-Performance Liquid Chromatography coupled to tandem mass spectrometry to determine cortisol in saliva samples from healthy mothers (n=87) and newborns (n=65) at different time points: (i) 38 weeks of gestation, (ii) in the immediate postnatal period (48h) after a term delivery and, (iii) 3 months after delivery. The procedure is characterized by a simple sample treatment employing a sample volume of 25μL. In addition to this, salivary α-amylase was determined using a commercial kit. We have proposed potential reference ranges in saliva for cortisol (0.7-35nmolL(-1)) and α-amylase (2-500UmL(-1)) in mothers, and for cortisol (0.1-56nmolL(-1)) and α-amylase (0.1-500UmL(-1)) in newborn infants. In addition, statistical differences between the two sensitive population groups (mothers and newborns) at the perinatal and postnatal periods were studied. A lower concentration for maternal cortisol was found at 38 weeks of gestation than at 48h (p=0.048) or 3 months after delivery (p=0.021). Similar results were found for the α-amylase determinations. Hence, higher concentrations than could be expected from a chronic stress marker were found at 3 months after delivery than at 38 weeks of gestation (p<0.001) or 48h after delivery (p<0.001). We conclude that this analytical method could be applied to further clinical research on perinatal and postnatal stress, such as threatened preterm labor and/or parenting stress, respectively.

  11. 9 CFR 206.3 - Monthly report.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... will be available on the Internet on the GIPSA Web site (http://www.usda.gov/gipsa/) and at USDA GIPSA... GIPSA through the Internet on the GIPSA Web site (http://www.usda.gov/gipsa/) or at USDA GIPSA, Suite... business day of each month. The monthly reports will be available on the Internet on the GIPSA Web...

  12. 9 CFR 206.3 - Monthly report.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... capacity, alone or in combination with other plants, specified in the definition of packer. (b) When is the... slaughtering capacity, alone or in combination with other plants specified in the definition of packer in § 206... reported on Form P&SP-341, which will be available on the Internet on the GIPSA Web site...

  13. 9 CFR 206.3 - Monthly report.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... capacity, alone or in combination with other plants, specified in the definition of packer. (b) When is the... slaughtering capacity, alone or in combination with other plants specified in the definition of packer in § 206... reported on Form P&SP-341, which will be available on the Internet on the GIPSA Web site...

  14. 9 CFR 206.3 - Monthly report.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... capacity, alone or in combination with other plants, specified in the definition of packer. (b) When is the... slaughtering capacity, alone or in combination with other plants specified in the definition of packer in § 206... reported on Form P&SP-341, which will be available on the Internet on the GIPSA Web site...

  15. A BCR-ABL1 cutoff of 1.5% at 3 months, determined by the GeneXpert system, predicts an optimal response in patients with chronic myeloid leukemia

    PubMed Central

    García-Gutiérrez, Valentín; Gómez-Casares, María T.; Puerta, José M.; Alonso-Domínguez, Juan M.; Osorio, Santiago; Hernández-Boluda, Juan C.; Collado, Rosa; Ramírez, María J.; Ibáñez, Fátima; Martín, María L.; Rodríguez-Gambarte, Juan D.; Martínez-Laperche, Carolina; Gómez, Montse; Fiallo, Dolly V.; Redondo, Sara; Rodríguez, Alicia; Ruiz-Nuño, Concepción; Steegmann, Juan L.

    2017-01-01

    In chronic myeloid leukemia (CML) patients, 3-month BCR-ABL1 levels have consistently been correlated with further outcomes. Monitoring molecular responses in CML using the GeneXpert (Cepheid) platform has shown an optimal correlation with standardized RQ-PCR (IS) when measuring BCR-ABL1 levels lower than 10%, as it is not accurate for values over 10%. The aim of the present study was to determine the predictive molecular value at three months on different outcome variables using the Xpert BCR-ABL1 MonitorTM assay (Xpert BCR-ABL1). We monitored 125 newly diagnosed consecutive CML patients in the chronic phase (CML-CP) using an automated method: Xpert BCR-ABL1. Only 5% of patients did not achieve an optimal response at 3 months, and the 10% BCR-ABL1 cutoff defined by RQ-PCR (IS) methods was unable to identify significant differences in the probabilities of achieving a complete cytogenetic response (CCyR) (50% vs. 87%, p = 0.1) or a major molecular response (MMR) (60% vs. 80%, p = 0.29) by 12 months. In contrast, a cutoff of 1.5% more accurately identified differences in the probabilities of achieving CCyR (98% vs. 54%, p<0.001) and MMR (88% vs. 56%, p<0.001) by 12 months, as well as probabilities of treatment changes (p = 0.005). Therefore, when using the Xpert BCR-ABL1 assay, a cutoff of 1.5% at 3 months could with high probability identify patients able to achieve an optimal response at 12 months. PMID:28278193

  16. A BCR-ABL1 cutoff of 1.5% at 3 months, determined by the GeneXpert system, predicts an optimal response in patients with chronic myeloid leukemia.

    PubMed

    García-Gutiérrez, Valentín; Gómez-Casares, María T; Puerta, José M; Alonso-Domínguez, Juan M; Osorio, Santiago; Hernández-Boluda, Juan C; Collado, Rosa; Ramírez, María J; Ibáñez, Fátima; Martín, María L; Rodríguez-Gambarte, Juan D; Martínez-Laperche, Carolina; Gómez, Montse; Fiallo, Dolly V; Redondo, Sara; Rodríguez, Alicia; Ruiz-Nuño, Concepción; Steegmann, Juan L; Jiménez-Velasco, Antonio

    2017-01-01

    In chronic myeloid leukemia (CML) patients, 3-month BCR-ABL1 levels have consistently been correlated with further outcomes. Monitoring molecular responses in CML using the GeneXpert (Cepheid) platform has shown an optimal correlation with standardized RQ-PCR (IS) when measuring BCR-ABL1 levels lower than 10%, as it is not accurate for values over 10%. The aim of the present study was to determine the predictive molecular value at three months on different outcome variables using the Xpert BCR-ABL1 MonitorTM assay (Xpert BCR-ABL1). We monitored 125 newly diagnosed consecutive CML patients in the chronic phase (CML-CP) using an automated method: Xpert BCR-ABL1. Only 5% of patients did not achieve an optimal response at 3 months, and the 10% BCR-ABL1 cutoff defined by RQ-PCR (IS) methods was unable to identify significant differences in the probabilities of achieving a complete cytogenetic response (CCyR) (50% vs. 87%, p = 0.1) or a major molecular response (MMR) (60% vs. 80%, p = 0.29) by 12 months. In contrast, a cutoff of 1.5% more accurately identified differences in the probabilities of achieving CCyR (98% vs. 54%, p<0.001) and MMR (88% vs. 56%, p<0.001) by 12 months, as well as probabilities of treatment changes (p = 0.005). Therefore, when using the Xpert BCR-ABL1 assay, a cutoff of 1.5% at 3 months could with high probability identify patients able to achieve an optimal response at 12 months.

  17. A 3-Month Randomized Controlled Pilot Trial of a Patient-Centered, Computer-Based Self-Monitoring System for the Care of Type 2 Diabetes Mellitus and Hypertension.

    PubMed

    Or, Calvin; Tao, Da

    2016-04-01

    This study was performed to evaluate the effects of a patient-centered, tablet computer-based self-monitoring system for chronic disease care. A 3-month randomized controlled pilot trial was conducted to compare the use of a computer-based self-monitoring system in disease self-care (intervention group; n = 33) with a conventional self-monitoring method (control group; n = 30) in patients with type 2 diabetes mellitus and/or hypertension. The system was equipped with a 2-in-1 blood glucose and blood pressure monitor, a reminder feature, and video-based educational materials for the care of the two chronic diseases. The control patients were given only the 2-in-1 monitor for self-monitoring. The outcomes reported here included the glycated hemoglobin (HbA1c) level, fasting blood glucose level, systolic blood pressure, diastolic blood pressure, chronic disease knowledge, and frequency of self-monitoring. The data were collected at baseline and at 1-, 2-, and 3-month follow-up visits. The patients in the intervention group had a significant decrease in mean systolic blood pressure from baseline to 1 month (p < 0.001) and from baseline to 3 months (p = 0.043) compared with the control group. Significant improvements in the mean diastolic blood pressure were seen in the intervention group compared with the control group after 1 month (p < 0.001) and after 2 months (p = 0.028), but the change was not significant after 3 months. No significant differences were observed between the groups in the fasting blood glucose level, the HbA1c level, or chronic disease knowledge. The frequency of self-monitoring of blood glucose level and blood pressure was similar in both groups. The performances of the tablet computer-assisted and conventional disease self-monitoring appear to be useful to support/maintain blood pressure and diabetes control. The beneficial effects of the use of electronic self-care resources and support provided via mobile technologies require further

  18. Calculation of the first static hyperpolarizability tensor of three-dimensional periodic compounds with a local basis set: A comparison of LDA, PBE, PBE0, B3LYP, and HF results

    NASA Astrophysics Data System (ADS)

    Orlando, Roberto; Lacivita, Valentina; Bast, Radovan; Ruud, Kenneth

    2010-06-01

    The computational scheme for the evaluation of the second-order electric susceptibility tensor in periodic systems, recently implemented in the CRYSTAL code within the coupled perturbed Hartree-Fock (HF) scheme, has been extended to local-density, gradient-corrected, and hybrid density functionals (coupled-perturbed Kohn-Sham) and applied to a set of cubic and hexagonal semiconductors. The method is based on the use of local basis sets and analytical calculation of derivatives. The high-frequency dielectric tensor (ɛ∞) and second-harmonic generation susceptibility (d) have been calculated with hybrid functionals (PBE0 and B3LYP) and the HF approximation. Results are compared with the values of ɛ∞ and d obtained from previous plane-wave local density approximation or generalized gradient approximation calculations and from experiment. The agreement is in general good, although comparison with experiment is affected by a certain degree of uncertainty implicit in the experimental techniques.

  19. [A case of metachronous invasive ductal carcinoma concomitant with intraductal papillary-mucinous neoplasm (IPMN) of the pancreas, which could not be detected in contrast-enhanced CT scan performed 3 months ago].

    PubMed

    Hasebe, Osamu; Ochi, Yasuhide; Hara, Etsuo; Suzawa, Kenichi; Seki, Ayako; Nagaya, Tadanobu; Tatai, Toshiharu; Jimbo, Yoko; Hosaka, Noriko

    2011-09-01

    A 61-year-old man had been followed up in another hospital under diagnosis of branch duct type IPMN for 4 years. Contrast-enhanced CT scan for regular check performed 3 months ago revealed no increase of IPMN and no pancreatic tumor. However, he complained of back pain after that, MRI was performed. It revealed a solid tumor in size of 25mm diameter at the head of pancreas. The tumor was apparent from IPMN in several imaging modalities. Pancreatoduodenectomy was performed under diagnosis of invasive ductal carcinoma concomitant with IPMN. Post-operative pathological findings revealed IPMN was adenoma with mild atypia, and solid tumor was diagnosed invasive ductal carcinoma with solitary minute liver metastasis.

  20. Long-lasting changes in morphine-induced locomotor sensitization and tolerance in Long-Evans mother rats as a result of periodic postpartum separation from the litter: a novel model of increased vulnerability to drug abuse?

    PubMed

    Kalinichev, Mikhail; Easterling, Keith W; Holtzman, Stephen G

    2003-02-01

    Daily postpartum separations from the litter produce enduring changes in anxiety and sensitivity to the antinociceptive effects of morphine in Long-Evans dams. We tested whether postpartum experience alters sensitivity to the effects of morphine on locomotor activity. Dams were tested 4-6 weeks after their pups were weaned, and had one of the following backgrounds: daily separation from the litter on postpartum days 2-14 for either 3 h (prolonged separation-LS) or 15 min (brief separation-BS), or no separation (nonhandled control-NH). After 2 consecutive days (B1-2) of baseline activity measurements, subjects were tested daily after s.c. injections of either morphine (10 mg/kg) or saline for 7 days and again on day 10. Beginning 5 days later, saline and 1.0-10 mg/kg of morphine were tested in all dams. On B1, LS and BS dams habituated slower than NH controls, yielding higher horizontal counts. LS dams failed to habituate across baseline days and were more active than other dams on B2. Sensitization, a progressive increase in horizontal activity, was more rapid and robust in LS and BS dams compared to NH animals. LS was the only group that developed tolerance to morphine-induced decreases in vertical activity. In LS dams with the history of morphine treatment, injection of saline resulted in higher horizontal activity and center time compared to saline-treated counterparts, indicative of conditioning. Among animals with a history of saline treatment, LS dams were more sensitive to morphine challenges than BS and NH dams. As a result of the robust and long-lasting increases in the ability of morphine to induce behavioral sensitization in litter-separated dams, periodic postpartum separation may represent a new animal model of increased vulnerability to substance abuse.

  1. Trends in paediatric rheumatology referral times and disease activity indices over a ten-year period among children and young people with Juvenile Idiopathic Arthritis: results from the childhood arthritis prospective Study

    PubMed Central

    McErlane, Flora; Foster, Helen E.; Carrasco, Roberto; Baildam, Eileen M.; Chieng, S. E. Alice; Davidson, Joyce E.; Ioannou, Yiannis; Wedderburn, Lucy R.; Thomson, Wendy

    2016-01-01

    Objectives. The medical management of JIA has advanced significantly over the past 10 years. It is not known whether these changes have impacted on outcomes. The aim of this analysis was to identify and describe trends in referral times, treatment times and 1-year outcomes over a 10-year period among children with JIA enrolled in the Childhood Arthritis Prospective Study. Methods. The Childhood Arthritis Prospective Study is a prospective inception cohort of children with new-onset inflammatory arthritis. Analysis included all children recruited in 2001–11 with at least 1 year of follow-up, divided into four groups by year of diagnosis. Median referral time, baseline disease pattern (oligoarticular, polyarticular or systemic onset) and time to first definitive treatment were compared between groups. Where possible, clinical juvenile arthritis disease activity score (cJADAS) cut-offs were applied at 1 year. Results. One thousand and sixty-six children were included in the analysis. The median time from symptom onset and referral to first paediatric rheumatology appointment (22.7–24.7 and 3.4–4.7 weeks, respectively) did not vary significantly (∼20% seen within 10 weeks of onset and ∼50% within 4 weeks of referral). For oligoarticular and polyarticular disease, 33.8–47 and 25.4–34.9%, respectively, achieved inactive disease by 1 year, with ∼30% in high disease activity at 1 year. A positive trend towards earlier definitive treatment reached significance in oligoarticular and polyarticular pattern disease. Conclusion. Children with new-onset JIA have a persistent delay in access to paediatric rheumatology care, with one-third in high disease activity at 1 year and no significant improvement over the past 10 years. Contributing factors may include service pressures and poor awareness. Further research is necessary to gain a better understanding and improve important clinical outcomes. PMID:27016664

  2. Deep-Sea Octopus (Graneledone boreopacifica) Conducts the Longest-Known Egg-Brooding Period of Any Animal

    PubMed Central

    Robison, Bruce; Seibel, Brad; Drazen, Jeffrey

    2014-01-01

    Octopuses typically have a single reproductive period and then they die (semelparity). Once a clutch of fertilized eggs has been produced, the female protects and tends them until they hatch. In most shallow-water species this period of parental care can last from 1 to 3 months, but very little is known about the brooding of deep-living species. In the cold, dark waters of the deep ocean, metabolic processes are often slower than their counterparts at shallower depths. Extrapolations from data on shallow-water octopus species suggest that lower temperatures would prolong embryonic development periods. Likewise, laboratory studies have linked lower temperatures to longer brooding periods in cephalopods, but direct evidence has not been available. We found an opportunity to directly measure the brooding period of the deep-sea octopus Graneledone boreopacifica, in its natural habitat. At 53 months, it is by far the longest egg-brooding period ever reported for any animal species. These surprising results emphasize the selective value of prolonged embryonic development in order to produce competitive hatchlings. They also extend the known boundaries of physiological adaptations for life in the deep sea. PMID:25075745

  3. Deep-sea octopus (Graneledone boreopacifica) conducts the longest-known egg-brooding period of any animal.

    PubMed

    Robison, Bruce; Seibel, Brad; Drazen, Jeffrey

    2014-01-01

    Octopuses typically have a single reproductive period and then they die (semelparity). Once a clutch of fertilized eggs has been produced, the female protects and tends them until they hatch. In most shallow-water species this period of parental care can last from 1 to 3 months, but very little is known about the brooding of deep-living species. In the cold, dark waters of the deep ocean, metabolic processes are often slower than their counterparts at shallower depths. Extrapolations from data on shallow-water octopus species suggest that lower temperatures would prolong embryonic development periods. Likewise, laboratory studies have linked lower temperatures to longer brooding periods in cephalopods, but direct evidence has not been available. We found an opportunity to directly measure the brooding period of the deep-sea octopus Graneledone boreopacifica, in its natural habitat. At 53 months, it is by far the longest egg-brooding period ever reported for any animal species. These surprising results emphasize the selective value of prolonged embryonic development in order to produce competitive hatchlings. They also extend the known boundaries of physiological adaptations for life in the deep sea.

  4. Periodically poled silicon

    NASA Astrophysics Data System (ADS)

    Hon, Nick K.; Tsia, Kevin K.; Solli, Daniel R.; Khurgin, Jacob B.; Jalali, Bahram

    2010-02-01

    Bulk centrosymmetric silicon lacks second-order optical nonlinearity χ(2) - a foundational component of nonlinear optics. Here, we propose a new class of photonic device which enables χ(2) as well as quasi-phase matching based on periodic stress fields in silicon - periodically-poled silicon (PePSi). This concept adds the periodic poling capability to silicon photonics, and allows the excellent crystal quality and advanced manufacturing capabilities of silicon to be harnessed for devices based on χ(2)) effects. The concept can also be simply achieved by having periodic arrangement of stressed thin films along a silicon waveguide. As an example of the utility, we present simulations showing that mid-wave infrared radiation can be efficiently generated through difference frequency generation from near-infrared with a conversion efficiency of 50% based on χ(2) values measurements for strained silicon reported in the literature [Jacobson et al. Nature 441, 199 (2006)]. The use of PePSi for frequency conversion can also be extended to terahertz generation. With integrated piezoelectric material, dynamically control of χ(2)nonlinearity in PePSi waveguide may also be achieved. The successful realization of PePSi based devices depends on the strength of the stress induced χ(2) in silicon. Presently, there exists a significant discrepancy in the literature between the theoretical and experimentally measured values. We present a simple theoretical model that produces result consistent with prior theoretical works and use this model to identify possible reasons for this discrepancy.

  5. Oscillations following periodic reinforcement.

    PubMed

    Monteiro, Tiago; Machado, Armando

    2009-06-01

    Three experiments examined behavior in extinction following periodic reinforcement. During the first phase of Experiment 1, four groups of pigeons were exposed to fixed interval (FI 16s or FI 48s) or variable interval (VI 16s or VI 48s) reinforcement schedules. Next, during the second phase, each session started with reinforcement trials and ended with an extinction segment. Experiment 2 was similar except that the extinction segment was considerably longer. Experiment 3 replaced the FI schedules with a peak procedure, with FI trials interspersed with non-food peak interval (PI) trials that were four times longer. One group of pigeons was exposed to FI 20s PI 80s trials, and another to FI 40s PI 160s trials. Results showed that, during the extinction segment, most pigeons trained with FI schedules, but not with VI schedules, displayed pause-peck oscillations with a period close to, but slightly greater than the FI parameter. These oscillations did not start immediately after the onset of extinction. Comparing the oscillations from Experiments 1 and 2 suggested that the alternation of reconditioning and re-extinction increases the reliability and earlier onset of the oscillations. In Experiment 3 the pigeons exhibited well-defined pause-peck cycles since the onset of extinction. These cycles had periods close to twice the value of the FI and lasted for long intervals of time. We discuss some hypotheses concerning the processes underlying behavioral oscillations following periodic reinforcement.

  6. Astrophysical implications of periodicity

    NASA Technical Reports Server (NTRS)

    Muller, Richard A.

    1988-01-01

    Two remarkable discoveries of the last decade have profound implications for astrophysics and for geophysics. These are the discovery by Alvarez et al., that certain mass extinctions are caused by the impact on the earth of a large asteroid or comet, and the discovery by Raup and Sepkoski that such extinctions are periodic, with a cycle time of 26 to 30 million years. The validity of both of these discoveries is assumed and the implications are examined. Most of the phenomena described depend not on periodicity, but just on the weaker assumption that the impacts on the earth take place primarily in showers. Proposed explanations for the periodicity include galactic oscillations, the Planet X model, and the possibility of Nemesis, a solar companion star. These hypotheses are critically examined. Results of the search for the solar companion are reported. The Deccan flood basalts of India have been proposed as the impact site for the Cretaceous impact, but this hypotheisis is in contradiction with the conclusion of Courtillot et al., that the magma flow began during a period of normal magnetic field. A possible resolution of this contradiction is proposed.

  7. Combination of White Blood Cell Count at Presentation With Molecular Response at 3 Months Better Predicts Deep Molecular Responses to Imatinib in Newly Diagnosed Chronic-Phase Chronic Myeloid Leukemia Patients.

    PubMed

    Qin, Ya-Zhen; Jiang, Qian; Jiang, Hao; Lai, Yue-Yun; Zhu, Hong-Hu; Liu, Yan-Rong; Jiang, Bin; Huang, Xiao-Jun

    2016-01-01

    The aim of this study was to evaluate the impact of white blood cell (WBC) counts at presentation on the achievement of deep molecular response.A total of 362 newly diagnosed chronic-phase chronic myeloid leukemia patients (CML-CP) receiving 400 mg/day imatinib were serially monitored for a median of 36 months (range 6-115).Patients showing an optimal response at 3, 6, and 12 months as defined by the 2013 European LeukemiaNet recommendations had significantly lower WBC counts at presentation than those showing nonoptimal responses (all P < 0.0001). Among the cutoff values with a similar Youden index, 150 × 10E9/L (abbreviated WBC > 150) was selected to identify the greatest amount of patients with the potential to achieve a sustained molecular response of 4.5 (MR4.5). Regardless of whether the Sokal risk score was included, the BCR-ABL value at 3 months, WBC counts at presentation, hemoglobin levels, and sex were the common independent predictors for an MR4.5, with the former 2 presenting the highest hazard risk. Low Sokal risk scores did not independently predict the achievement of an MR4.5. Patients with concurrent WBC > 150 and BCR-ABL(IS) ≤ 10% had a similar incidence of 4-year MR4.5 compared with patients with concurrent WBC ≤ 150 and BCR-ABL(IS) > 10% and concurrent WBC > 150 and BCR-ABL(IS) > 10% (13.5% vs 13.2% vs 8.8%, P = 0.47), and all of these values were significantly lower than the values for patients with concurrent WBC ≤ 150 and BCR-ABL(IS) ≤ 10% (55.0%, all P < 0.0001). Patients with concurrent WBC ≤ 150 and BCR-ABL(IS) ≤ 10% had better 4-year event-free survival rates, progression-free survival rates, and overall survival rates compared with patients with WBC > 150 or BCR-ABL(IS) > 10%. The combination of WBC count at presentation and BCR-ABL(IS) at 3 months provides improved predictions of deep molecular response in imatinib-treated CML-CP patients. Therefore, the WBC count at presentation might be used to

  8. Hypokalemic periodic paralysis

    MedlinePlus

    Periodic paralysis - hypokalemic; Familial hypokalemic periodic paralysis; HOKPP; HypoKPP; HypoPP ... is not inherited. Unlike other forms of periodic paralysis, people with hypoPP have normal thyroid function. But ...

  9. Hyperkalemic periodic paralysis

    MedlinePlus

    Periodic paralysis - hyperkalemic; Familial hyperkalemic periodic paralysis; HyperKPP; HyperPP; Gamstorp disease ... factors include having other family members with periodic paralysis. It affects men more often than women.

  10. Cells anticipate periodic events

    NASA Astrophysics Data System (ADS)

    Nakagaki, Toshiyuki

    2009-03-01

    We show that an amoeboid organism can anticipate the timing of periodic events. The plasmodium of the true slime mold Physarum polycephalum moves rapidly under favourable conditions, but stops moving when transferred to less-favourable conditions. Plasmodia exposed to unfavourable conditions, presented in three consecutive pulses at constant intervals, reduced their locomotive speed in response to each episode. When subsequently subjected to favourable conditions, the plasmodia spontaneously reduced their locomotive speed at the time point when the next unfavourable episode would have occurred. This implied anticipation of impending environmental change. After this behaviour had been evoked several times, the locomotion of the plasmodia returned to normal; however, the anticipatory response could subsequently be induced by a single unfavourable pulse, implying recall of the memorized periodicity. We explored the mechanisms underlying these behaviours from a dynamical systems perspective. Our results hint at the cellular origins of primitive intelligence and imply that simple dynamics might be sufficient to explain its emergence.

  11. Vaginal bleeding between periods

    MedlinePlus

    ... periods; Intermenstrual bleeding; Spotting; Metrorrhagia Images Female reproductive anatomy Bleeding between periods Uterus References Bulun SE. The physiology and pathology of the female reproductive axis. In: ...

  12. Behavioral changes in autistic individuals as a result of wearing ambient transitional prism lenses.

    PubMed

    Kaplan, M; Edelson, S M; Seip, J A

    1998-01-01

    A double-blind crossover design was used to assess the efficacy of wearing ambient lenses to reduce the behavioral symptoms of autism. Eighteen autistic individuals, ranging in age from 7 to 18 years, participated in the study. Behavior, attention, and orientation were evaluated at 1 1/2 months, 2 months, 3 months, and 4 months. Compared to the placebo condition, the results showed a decrease in behavior problems at the 1 1/2 and 2 month assessment periods and a slight loss of these benefits at the 3 and 4 month assessment periods. These findings support the prediction that ambient lenses, worn without engaging in visual-motor exercises, have positive effects on autistic individuals.

  13. Effect of lavender scent inhalation on prevention of stress, anxiety and depression in the postpartum period

    PubMed Central

    Kianpour, Maryam; Mansouri, Akram; Mehrabi, Tayebeh; Asghari, Gholamreza

    2016-01-01

    Background: Stress, anxiety, and postpartum depression are the most common problems among women in their childbearing age. Research has shown that aromatherapy administered during labor reduces anxiety in mothers. With regard to the specific biological conditions in postpartum period and the subsequent drop in hormone levels, this study investigated the effect of lavender on prevention of stress, anxiety, and postpartum depression in women. Materials and Methods: In a clinical trial, 140 women admitted to the obstetric and gynecological unit were randomly divided into aromatherapy and non-aromatherapy groups immediately after delivery. Intervention with aromatherapy consisted of inhaling three drops of lavender essential oil every 8 h with for 4 weeks. The control group received routine care after discharge and was followed up by telephone only. After 2 weeks, 1 and 3 months of delivery, women were assessed by the 21-item Depression, Anxiety, and Stress Scale and the Edinburgh stress, anxiety, and depression scale in the two groups. Data analysis was performed by Mann-Whitney, analysis of variance (ANOVA), and post hoc tests. Level of significance was set as 0.05 for all tests. Results: The results showed that the mean stress, anxiety, and depression at time point of 2 weeks (P = 0.012, P < 0.0001, and P = 0.003, respectively) and stress, anxiety, and depression scores at time points of 1 month (P < 0.0001) and 3 months after delivery (P < 0.0001) were significantly lower in the study group compared with the control group. Conclusions: Inhaling the scent of lavender for 4 weeks can prevent stress, anxiety, and depression after childbirth. PMID:27095995

  14. Evidence of past climate change in the Little Ice Age and of the Pacific Decadal Oscillation periodicity in Africa: comparison between two neighbor stalagmites from Namibia and Botswana (preliminary results)

    NASA Astrophysics Data System (ADS)

    Voarintsoa, N. G.; Railsback, L. B.; Liang, F.; Brook, G. A.; Cheng, H.; Edwards, R.

    2013-12-01

    Stalagmites are potential sources of paleoenvironmental records because their characteristics respond to climate change. In this preliminary study we compare isotopic values resolvable at annual to bi-annual scale from two stalagmites from caves in Proterozoic dolomitic marbles, as a proxy for the past climate variability in Southern Africa. Stalagmite DP1 is from Dante Cave in the Otjozondjupa region of Namibia, and Stalagmite BC97-14 is from Bone Cave, in the Koanaka Hills of Northwest Botswana, ~125km west of the Okavango Delta. Dante and Bone Cave receive respectively ~532 and ~475mm annual rainfall with an annual average temperature of 21.0°C and 22.6°C. Both caves are in semi-arid areas with highly seasonal rainfall. Vegetation is distinctive for each location: deciduous woodland savanna with a relatively high diversity of scattered tall trees on the hill in which Dante is located and a sparser tree cover on the hillsite of Bone Cave area. The data from the two stalagmites are very different, reflecting the distinctive hydrological and vegetation settings of the caves where they formed. δ18O in BC97-14 is highly variable, ranging from -11.6 to -5.8 ‰, while δ13C is nearly constant (-10.5 to -8.5 ‰). In contrast, δ13C and δ18O are covariant in DP1, with much higher δ13C values (-10.8 to -5.1‰) and much lower δ18O (-11.7 to -6.5 ‰) compared to that of Bone Cave. The distance from the water vapor source (Indian Ocean) might explain the generally lower δ18O values from the Namibian stalagmite compared to that of Botswana; while the difference in vegetation cover reflects the difference between δ13C for the two areas. Regardless of this isotopic difference, the stalagmite data for Bone Cave show a marked 15- to 22-year periodicity that is much more subdued in the Namibia speleothem. This cycle matches with the 17- or 18-year periodicity in the Botswana historical rainfall record. The periodicity is very well pronounced between AD 1825 to 1925

  15. The postanesthetic period. Complications.

    PubMed

    Malamed, S F

    1987-01-01

    Postanesthetic complications can occur even in the best of circumstances. Proper preparation of the staff, aggressive monitoring of the recovering patient, and early recognition and management of the complications are essential if the outcome is to be successful. In reviewing postanesthetic complications, two factors are present in the overwhelming majority of situations--hypoxia and hypercarbia--often the direct result of inadequate monitoring during the postanesthetic period. The anesthetic procedure is not over once the anesthetic agents are discontinued. The skillful anesthetist is aware of the possibilities of postoperative complications and prevents problems by employing enhanced monitoring techniques during the recovery phase.

  16. Experimental scoliosis in the course of unilateral surface electrostimulation of the paravertebral muscles in rabbits: effects according to stimulation period.

    PubMed

    Kowalski, I M; Szarek, J; Zarzycki, D; Rymarczyk, A

    2001-12-01

    Scoliosis among children and adolescents is a persistent problem. Worldwide, it afflicts between 0.3 to 15.3% of the population. One of the treatment methods of this disorder is to administer lateral electrical surface stimulation (LESS) for 9 h/day; unfortunately, however, this results in side-effects. Improvements are therefore sought. The main aim of the study was to investigate the effects of the duration of LESS on scoliosis progression and to evaluate, qualitatively, any associated macroscopic effect on other internal organs. The length of the LESS period was based on the results of previous clinical trials in children. The experiment was performed on 13 developing rabbits (aged 3.5 months), divided into three groups: group 1, rabbits subsequently treated for 9 h/day (n=5); group 2, animals treated for 2 h/day (n=5); group 3, control rabbits without electrostimulation (n=3). Stimulation was carried out using an electric stimulator SCOL-2 according to the method modified by Kowalski. The animals were killed after 3 months and examined macroscopically, and their adrenal glands were dissected and weighed. The X-rays of the spine of the animals were taken to analyse spinal deformity. Macroscopic lesions in rabbits from groups 2 and 3 (control) were mostly absent. While there was considerable deviation in group 1, all the stress features were apparent. The enlargement of the adrenal glands observed in group 2 was significantly less marked than in group 1. The degree of scoliotic deformity (according to the Cobb method) ranged from 21 degrees to 410 degrees (mean, 31.2 degrees) and from 23 degrees to 330 degrees (mean, 30 degrees) in groups 1 and 2, respectively. LESS resulted in spinal deformity to a similar degree in the rabbits treated for either 9 or 2 h/day over a 3-month period. Short LESS therapy (2 h/day) significantly reduced detrimental effects associated with the treatment on internal organs of laboratory animals.

  17. Assessment of spatiotemporal variability of drought in Weihe River over the period 1960-2010

    NASA Astrophysics Data System (ADS)

    Chang, Jianxia; Li, YunYun; Ren, Yi; Chen, Yutong

    2015-04-01

    The SPI is a valuable tool for quantifying the impacts of drought and comparing the intensity of drought across time and space. In this paper, we examine the spatial and temporal characteristics of droughts in WRB which are showing decreasing trends (becoming drier) over the twentieth century through the SPI series computed on 3-month, 6-month and 12-month time scales. According to the results, moderate drought were the major drought in the WRB, and the main drought periods were detected in1991-2000, while the extremely dry year was 1995 and 1997 at most of the stations. The annual minimum SPI values for the 3-month and 6-month time scale most frequently occured during July and October. The trend of SPI-3 showed that the risk of spring and fall drought increased gradually, which will impact on agriculture and water supply. Spatial, the areas with lower mean precipitation values had the largest decrease in SPI, especially in the Northern area. The decreasing trend was detected in the whole basin for SPI-12 and SPI-6. According to the SPI-3, all of the region had a decreasing trend in summer and fall, while winter showed little variation with most of the region had a decreasing trend. Summer showed the most increase throughout the east, with some areas of decrease confined mostly in the north and northwest area. So, there is strong relation between the rainfall distribution and drought potential zones in the basin. The meteorological drought conditions change continuously with seasons depending upon precipitation amount and its spatial distribution.

  18. Period meter for reactors

    DOEpatents

    Rusch, Gordon K.

    1976-01-06

    An improved log N amplifier type nuclear reactor period meter with reduced probability for noise-induced scrams is provided. With the reactor at low power levels a sampling circuit is provided to determine the reactor period by measuring the finite change in the amplitude of the log N amplifier output signal for a predetermined time period, while at high power levels, differentiation of the log N amplifier output signal provides an additional measure of the reactor period.

  19. The Periodic Pyramid

    ERIC Educational Resources Information Center

    Hennigan, Jennifer N.; Grubbs, W. Tandy

    2013-01-01

    The chemical elements present in the modern periodic table are arranged in terms of atomic numbers and chemical periodicity. Periodicity arises from quantum mechanical limitations on how many electrons can occupy various shells and subshells of an atom. The shell model of the atom predicts that a maximum of 2, 8, 18, and 32 electrons can occupy…

  20. Community College Periodicals.

    ERIC Educational Resources Information Center

    Pederson, Eldor O.

    Drawing from an examination of community college periodicals, their availability and characteristics, the academic affiliations of contributing authors, and the topics of their articles, this paper discusses the minor role which community college periodicals appear to play. A list of 35 periodicals dealing primary with community college education…

  1. Effect on treadmill exercise capacity, myocardial ischemia, and left ventricular function as a result of repeated whole-body periodic acceleration with heparin pretreatment in patients with angina pectoris and mild left ventricular dysfunction.

    PubMed

    Miyamoto, Shoichi; Fujita, Masatoshi; Inoko, Moriaki; Oba, Muneo; Hosokawa, Ryohei; Haruna, Tetsuya; Izumi, Toshiaki; Saji, Yoshiaki; Nakane, Eisaku; Abe, Tomomi; Ueyama, Koji; Nohara, Ryuji

    2011-01-15

    Whole-body periodic acceleration (WBPA) has been developed as a passive exercise device capable of improving endothelial function by applying pulsatile shear stress to vascular endothelium. We hypothesized that treatment with WBPA improves exercise capacity, myocardial ischemia, and left ventricular (LV) function because of increased coronary and peripheral vasodilatory reserves in patients with angina. Twenty-six patients with angina who were not indicated for percutaneous coronary intervention and/or coronary artery bypass grafting were randomly assigned to remain sedentary (sedentary group) or undergo 20 sessions of WBPA with the motion platform for 4 weeks (WBPA group) in addition to conventional medical treatment. WBPA was applied at 2 to 3 Hz and approximately ±2.2 m/s² for 45 minutes. We repeated the symptom-limited treadmill exercise test and adenosine sestamibi myocardial scintigraphy. In the WBPA group, the exercise time until 0.1-mV ST-segment depression increased by 53% (p <0.01) and the double product at 0.1-mV ST-segment depression by 23% (p <0.001). Severity score of myocardial scintigraphy during adenosine infusion decreased from 20 ± 10 to 14 ± 8 (p <0.001) and severity score at rest also decreased from 13 ± 10 to 8 ± 10 (p <0.01). On scintigraphic images at rest, LV end-diastolic volume index decreased by 18% (p <0.01) with an augmentation of LV ejection fraction from 50 ± 16% to 55 ± 16% (p <0.01). In contrast, all studied parameters remained unchanged in the sedentary group. In conclusion, treatment with WBPA for patients with angina ameliorates exercise capacity, myocardial ischemia, and LV function.

  2. Forward Period Analysis Method of the Periodic Hamiltonian System

    PubMed Central

    Wang, Pengfei

    2016-01-01

    Using the forward period analysis (FPA), we obtain the period of a Morse oscillator and mathematical pendulum system, with the accuracy of 100 significant digits. From these results, the long-term [0, 1060] (time unit) solutions, ranging from the Planck time to the age of the universe, are computed reliably and quickly with a parallel multiple-precision Taylor series (PMT) scheme. The application of FPA to periodic systems can greatly reduce the computation time of long-term reliable simulations. This scheme provides an efficient way to generate reference solutions, against which long-term simulations using other schemes can be tested. PMID:27727295

  3. Tissue integration of one-stage ITI implants: 3-year results of a longitudinal study with Hollow-Cylinder and Hollow-Screw implants.

    PubMed

    Buser, D; Weber, H P; Bragger, U; Balsiger, C

    1991-01-01

    This study examined the tissue integration of one-stage, nonsubmerged ITI implants over a period of 3 years. Fifty-four implants were placed in 38 partially edentulous patients. Following healing (at least 3 months), all 54 implants were free of peri-implant infections and revealed no detectable mobility. Radiographs showed no signs of peri-implant radiolucencies, and the implants were in favorable positions for prosthetic restoration. Following incorporation of fixed partial dentures, patients were enrolled in a hygiene recall program with 3-month intervals and were examined once a year. Based on predefined criteria, each implant was classified as successful or failing. After the 3-year observation period, 51 of 53 implants (96.2%) were considered successfully integrated. (One patient with one implant dropped out of the study.) Two implants exhibited recurrent peri-implant infections and were classified as late failures. These results indicate that one-stage ITI implants can achieve successful tissue integration on a predictable basis and that it can be maintained over a period of at least 3 years.

  4. Inter-comparison of radon detectors for one to four week measurement periods.

    PubMed

    Gunning, G A; Murray, M; Long, S C; Foley, M J; Finch, E C

    2016-03-01

    Seven different types of radon detectors (Atmos 12 dpx, RAD7, RStone, Sun Nuclear 1028, Ramon 2.2, Canary and CR-39) were compared for exposure periods of 1, 2, 3 and 4 weeks. The comparison was conducted under two conditions: (a) in a purpose-built radon chamber with an average radon concentration of 2560 Bq m(-3) (b) in a home environment with a radon concentration of 57 Bq m(-3), in both cases measured by the reference detector (Atmos 12 dpx) with a  ±10% uncertainty range. In (a) 5 out of 8 detectors recorded radon concentrations within the Atmos uncertainty range and all detectors recorded within  ±15%; in (b) 3 out of 9 detectors recorded within the Atmos uncertainty range and 6 out of 9 measured within  ±20%, for a 4 week measurement. The results from this study show that radon surveys can be conducted for shorter periods than the recommended 3 months where a rapid indication is needed of whether the radon concentration is above the reference level, such as when assessing the concentration during and after remediation work.

  5. Group B streptococcal meningitis in children beyond the neonatal period in sub-Himalayan India

    PubMed Central

    Chauhan, Divya; Mokta, Kiran; Kanga, Anil; Grover, Neelam; Singh, Digvijay; Bhagra, Suruchi

    2015-01-01

    Objectives: To evaluate clinicolaboratory profile and the outcomes in children (1 to 59 months) diagnosed with Group B streptococcus (GBS) meningitis over a period of 1 year. Materials and Methods: Cerebrospinal fluid (CSF) samples of 250 pediatric patients (1 to 59 months) admitted with suspected acute bacterial meningitis(ABM)were subjected to cell count, biochemical profile, culture, latex particle agglutination (LPA) and polymerase chain reaction (PCR). They were also evaluated for complications and were followed-up till 6 months after discharge. Results: Forty patients (25 boys and 15 girls), 16% of total suspected cases of ABM were diagnosed with GBS by LPA method and 30 (75%) out of these were above 3 months of age. The median duration of hospital stay was 7 days (range 1 to 72 days). State of coma was observed in two (5%) and one (2.5%) died, while 20 (50%) patients recovered completely. Conclusion: GBS should be considered as an important cause of ABM in Indian children beyond the neonatal period and further studies are warranted to determine the actual problem of the disease in our country. PMID:25745315

  6. Periodic and Quasi-Periodic Orbitsfor the Standard Map

    NASA Astrophysics Data System (ADS)

    Berretti, Alberto; Gentile, Guido

    We consider both periodic and quasi-periodic solutions for the standard map, and we study the corresponding conjugating functions, i.e. the functions conjugating the motions to trivial rotations. We compare the invariant curves with rotation numbers ω satisfying the Bryuno condition and the sequences of periodic orbits with rotation numbers given by their convergents ωN = pN/qN. We prove the following results for N--> ∞: (1) for rotation numbers ωNN we study the radius of convergence of the conjugating functions and we find lower bounds on them, which tend to a limit which is a lower bound on the corresponding quantity for ω (2) the periodic orbits consist of points which are more and more close to the invariant curve with rotation number ω (3) such orbits lie on analytical curves which tend uniformly to the invariant curve.

  7. Periodic chiral structures

    NASA Technical Reports Server (NTRS)

    Jaggard, Dwight L.; Engheta, Nader; Pelet, Philippe; Liu, John C.; Kowarz, Marek W.; Kim, Yunjin

    1989-01-01

    The electromagnetic properties of a structure that is both chiral and periodic are investigated using coupled-mode equations. The periodicity is described by a sinusoidal perturbation of the permittivity, permeability, and chiral admittance. The coupled-mode equations are derived from physical considerations and used to examine bandgap structure and reflected and transmitted fields. Chirality is observed predominantly in transmission, whereas periodicity is present in both reflection and transmission.

  8. The dependence of honey-bee behaviour on weather — Shown by the results of weighing bee-hives in the period of 1969 to 1978 in the region of the Beekeepers Association of Hannover

    NASA Astrophysics Data System (ADS)

    Gerlach, Jutta

    1985-03-01

    This paper presents the results of an investigation of honey bee behaviour and their dependence on weather conditions. The main interest of the data evaluation was the rentability of beekeeping, especially the amount of honey produced, meteorological parameters were used to analyse the measurements. So-called “hive scale” measurements, a method used to judge the annual development of honey bees, were carried out in the region of the “Landesverband Hannoverscher Imker e. V.” by 30 to 35 observers from 1969 to 1978 under the direction of Wagener. Number of flight and forage days were collected in addition to climatic data and evaluated.

  9. Periodic Solutions of Spatially Periodic Hamiltonian Systems

    DTIC Science & Technology

    1989-07-10

    Theorem 0.2 generalizes Theorem 1.5 of Rabinowitz in [201. 3 Equation (0.1), under spatially periodic assumptions has been studied by several au...n x n symmetric matrix, H satisfying (HO), (H1) and (H2), and f = (0, fq) satisfying (fM), (fl) and (f2), Rabinowitz in [201 showed the existence of... Rabinowitz [17]. We consider a functional I : E x M ) R of class C’, where E is a Hilbert space and M is a compact manifold. Assuming that I satisfies a

  10. The Living Periodic Table

    ERIC Educational Resources Information Center

    Nahlik, Mary Schrodt

    2005-01-01

    To help make the abstract world of chemistry more concrete eighth-grade students, the author has them create a living periodic table that can be displayed in the classroom or hallway. This display includes information about the elements arranged in the traditional periodic table format, but also includes visual real-world representations of the…

  11. Multidimensional period doubling structures.

    PubMed

    Lee, Jeong Yup; Flom, Dvir; Ben-Abraham, Shelomo I

    2016-05-01

    This paper develops the formalism necessary to generalize the period doubling sequence to arbitrary dimension by straightforward extension of the substitution and recursion rules. It is shown that the period doubling structures of arbitrary dimension are pure point diffractive. The symmetries of the structures are pointed out.

  12. Latent Period of Relaxation.

    PubMed

    Kobayashi, M; Irisawa, H

    1961-10-27

    The latent period of relaxation of molluscan myocardium due to anodal current is much longer than that of contraction. Although the rate and the grade of relaxation are intimately related to both the stimulus condition and the muscle tension, the latent period of relaxation remains constant, except when the temperature of the bathing fluid is changed.

  13. Bragg interactions in periodic media

    NASA Technical Reports Server (NTRS)

    Jaggard, D. L.

    1976-01-01

    The interaction of electromagnetic waves of wavelength lambda with periodic structures of spatial period lambda are studied. The emphasis of the work is on Bragg interactions where lambda approximately equal to 2 lambda/N and the Bragg order N takes on the values 1, 2,.... An extended coupled waves (ECW) theory is developed for the case N greater or equal to 2 and the results of the theory are found to compare favorably with the exact results of Floquet theory. Numerous numerical results are displayed as Brillouin diagrams for the first few Bragg orders. Moreover, explicit expressions for coupling coefficients, bandgap shifts and bandgap widths are derived for singly periodic media. Particular note is taken of phase speeding effects.

  14. Periodically poled silicon

    NASA Astrophysics Data System (ADS)

    Hon, Nick K.; Tsia, Kevin K.; Solli, Daniel R.; Jalali, Bahram

    2009-03-01

    We propose a new class of photonic devices based on periodic stress fields in silicon that enable second-order nonlinearity as well as quasi-phase matching. Periodically poled silicon (PePSi) adds the periodic poling capability to silicon photonics and allows the excellent crystal quality and advanced manufacturing capabilities of silicon to be harnessed for devices based on second-order nonlinear effects. As an example of the utility of the PePSi technology, we present simulations showing that midwave infrared radiation can be efficiently generated through difference frequency generation from near-infrared with a conversion efficiency of 50%.

  15. Global blackout following the K/T Chicxulub impact: Results of impact and atmospheric modeling

    NASA Technical Reports Server (NTRS)

    Pope, K. O.; Ocampo, A. C.; Baines, K. H.; Ivanov, B. A.

    1993-01-01

    Several recent studies have suggested that shock decomposition of anhydrite (CaSO4) target rocks during the K/T Chicxulub impact would have ejected tremendous amounts of sulfur gas into the stratosphere. One of the many potential biospheric effects of this sulfur gas is the generation of a sulfuric acid (H2SO4) aerosol layer capable of causing darkness and severe disruption of photosynthesis for periods of years. In this paper we report the preliminary results of our modeling of shock pressures within the anhydrites and of light attenuation by the H2SO4 aerosol cloud. These models indicate that earlier studies over-estimated the amount of sulfur gas produced, but that more than enough was produced to extend global blackout conditions 4-6 times longer than the approximately 3 month predictions for silicate dust alone.

  16. The Periodic Table CD.

    ERIC Educational Resources Information Center

    Banks, Alton J.; Holmes, Jon L.

    1995-01-01

    Describes the characteristics of the digitized version of The Periodic Table Videodisc. Provides details about the organization of information and access to the data via Macintosh and Windows computers. (DDR)

  17. Fast excitation variable period wiggler

    SciTech Connect

    van Steenbergen, A.; Gallardo, J.; Romano, T.; Woodle, M.

    1991-01-01

    The design of an easily stackable, variable period length, fast excitation driven wiggler, making use of geometrically alternating substacks of Vanadium Permandur ferromagnetic laminations, interspaced with conductive, non magnetic, laminations which act as eddy current induced field reflectors,'' is discussed and experimental results obtained with short wiggler models are presented.

  18. Fast excitation variable period wiggler

    SciTech Connect

    van Steenbergen, A.; Gallardo, J.; Romano, T.; Woodle, M.

    1991-12-31

    The design of an easily stackable, variable period length, fast excitation driven wiggler, making use of geometrically alternating substacks of Vanadium Permandur ferromagnetic laminations, interspaced with conductive, non magnetic, laminations which act as eddy current induced ``field reflectors,`` is discussed and experimental results obtained with short wiggler models are presented.

  19. Cochlear neuropathy in the rat exposed for a long period to moderate-intensity noises.

    PubMed

    Gannouni, Noura; Lenoir, Marc; Ben Rhouma, Khemais; El May, Michèle; Tebourbi, Olfa; Puel, Jean Luc; Mhamdi, Abada

    2015-06-01

    Damaging effects on the cochlea of high-intensity acoustic overexposures have been extensively documented, but only few works have focused on the danger of moderate noise levels. Using scanning and transmission electron microscopy, we explored the noise-induced neuroepithelial changes that occur in the cochlea of rats subjected to moderate intensities, 70 and 85 dB SPL, for an extended period of time (6 hr/day over 3 months). Although the full quota of outer and inner sensory hair cells remained present, we detected discrete abnormalities, likely resulting from metabolic impairment, in both types of hair cell within the basal region of the cochlea. In contrast, important noise-dependent losses of spiral ganglion neurons had occurred. In addition, we found cytoplasmic accumulations of lipofuscin-like aggregates in most of the surviving cochlear neurons. These results strongly suggest that noise levels comparable to those of certain working environments, with sufficient exposure duration, pose a severe risk to the cochlea. Moreover, our data support the notion that long-duration exposure to moderate noise is a causative factor of presbycusis.

  20. Microbial biofilm proliferation within sealer-root dentin interfaces is affected by sealer type and aging period

    PubMed Central

    Roth, Karina A; Friedman, Shimon; Lévesque, Céline M; Basrani, Bettina R; Finer, Yoav

    2012-01-01

    Background Root canal fillings are intended to prevent microbial proliferation over time in the canal after treatment. Objective To assess biofilm proliferation within the sealer-dentin interfaces of two methacrylate resin-based systems, self-etch (SE) and total-etch (TE), and an epoxy resin-based sealer (EP), aged for up to 6 months. Methods Standardized specimens (n=45) comprising the coronal 5 mm of human roots were filled with the test materials and gutta-percha. Specimens were either not pre-incubated (control; n=9), or incubated in sterile saline for 1 week, 1 month, 3 months or 6 months (n=3/group). Monospecies biofilms of Enterococcus faecalis were grown on the specimens for 7 days in a chemostat-based biofilm fermentor mimicking pathogenic oral conditions. The extent of E. faecalis proliferation within the sealer-dentin interface for each material and incubation period group was assessed using fluorescence microscopy of dihydroethidium-stained specimens. Results TE had less biofilm proliferation than both EP and SE (p<0.01). Deeper biofilm proliferation was detected in SE and EP specimens aged for 1 and 3 months than those aged for 1 week or 6 months (p<0.05). Maximum depth of biofilm penetration was recorded for SE at 1 month (p<0.05). Conclusion Within the test model used, the self-etch and epoxy resin-based sealers were more susceptible to interfacial biofilm proliferation than the total-etch restorative material. This susceptibility diminished after aging the materials’ interfaces for 6 months. PMID:22892745

  1. Stability of underwater periodic locomotion

    NASA Astrophysics Data System (ADS)

    Jing, Fangxu; Kanso, Eva

    2013-07-01

    Most aquatic vertebrates swim by lateral flapping of their bodies and caudal fins. While much effort has been devoted to understanding the flapping kinematics and its influence on the swimming efficiency, little is known about the stability (or lack of) of periodic swimming. It is believed that stability limits maneuverability and body designs/flapping motions that are adapted for stable swimming are not suitable for high maneuverability and vice versa. In this paper, we consider a simplified model of a planar elliptic body undergoing prescribed periodic heaving and pitching in potential flow. We show that periodic locomotion can be achieved due to the resulting hydrodynamic forces, and its value depends on several parameters including the aspect ratio of the body, the amplitudes and phases of the prescribed flapping.We obtain closedform solutions for the locomotion and efficiency for small flapping amplitudes, and numerical results for finite flapping amplitudes. This efficiency analysis results in optimal parameter values that are in agreement with values reported for some carangiform fish. We then study the stability of the (finite amplitude flapping) periodic locomotion using Floquet theory. We find that stability depends nonlinearly on all parameters. Interesting trends of switching between stable and unstable motions emerge and evolve as we continuously vary the parameter values. This suggests that, for live organisms that control their flapping motion, maneuverability and stability need not be thought of as disjoint properties, rather the organism may manipulate its motion in favor of one or the other depending on the task at hand.

  2. Hyperthyroid hypokalemic periodic paralysis

    PubMed Central

    Neki, N.S.

    2016-01-01

    Hyperthyroid periodic paralysis (HPP) is a rare life threatening complication of hyperthyroidism commonly occurring in young Asian males but sporadically found in other races. It is characterised by hypokalemia and acute onset paraparesis with prevalence of one in one hundred thousand (1 in 100000). The symptoms resolve promptly with potassium supplementation. Nonselective beta blockers like propranol can also be used to ameliorate and prevent subsequent paralytic attack. We report a case of 22 year old male presenting with hyperthyroid periodic paralysis (HPP) having very low serum potassium level. PMID:27648066

  3. Effects of mobile phone WeChat services improve adherence to corticosteroid nasal spray treatment for chronic rhinosinusitis after functional endoscopic sinus surgery: a 3-month follow-up study.

    PubMed

    Feng, Shaoyan; Liang, Zibin; Zhang, Rongkai; Liao, Wei; Chen, Yuan; Fan, Yunping; Li, Huabin

    2017-03-01

    The objective of the study is to investigate the impact of receiving daily WeChat services on one's cell phone on adherence to corticosteroid nasal spray treatment in chronic rhinosinusitis (CRS) patients after functional endoscopic sinus surgery (FESS). This study was a two-arm, randomized, follow-up investigation. Patients with chronic rhinosinusitis with/without nasal polyps following bilateral FESS were randomised to receive, or to not receive, daily WeChat service on their cell phone to take corticosteroid nasal spray treatment. A prescription of budesonide aqueous nasal spray 128 µg bid was given to all the subjects. Then they returned to the clinic after 30, 60, 90 days. The primary study outcome was adherence to nasal spray treatment, whereas secondary outcomes were change in endoscopic findings and SinoNasal Outcome Test-20 (SNOT-20). On the whole, there was a significant inter-group difference in the change of adherence rate (F = 90.88, p = 0.000). The WeChat group had much higher adherence rate than the control group during the follow-up. In terms of postoperative endoscopic scores and SNOT-20, except granulation score, no significant differences were observed between the two randomization groups. WeChat services are already after a short period of observation associated with improved adherence to corticosteroid nasal spray treatment in CRS patients after FESS.

  4. A Modern Periodic Table.

    ERIC Educational Resources Information Center

    Herrenden-Harker, B. D.

    1997-01-01

    Presents a modern Periodic Table based on the electron distribution in the outermost shell and the order of filling of the sublevels within the shells. Enables a student to read off directly the electronic configuration of the element and the order in which filling occurs. (JRH)

  5. Periodic Table of Students.

    ERIC Educational Resources Information Center

    Johnson, Mike

    1998-01-01

    Presents an exercise in which an eighth-grade science teacher decorated the classroom with a periodic table of students. Student photographs were arranged according to similarities into vertical columns. Students were each assigned an atomic number according to their placement in the table. The table is then used to teach students about…

  6. Periodically structured plasmonic waveguides

    NASA Astrophysics Data System (ADS)

    Saj, W. M.; Foteinopoulou, S.; Kafesaki, M.; Soukoulis, C. M.; Economou, E. N.

    2008-04-01

    We study surface plasmon polariton (SPP) guiding structures, which are a modification of the Metal-Insulator-Metal (MIM) waveguide. The designs are constructed by introducing a periodic modulation in a MIM waveguide, with a glass core and silver claddings. This periodic modulation is created either by causing periodic indentations in the silver slabs encompassing the glass core, or by increasing the glass spacer material in certain periodic locations. Our objective is to achieve long range sub-wavelength waveguiding with vast dispersion engineering capabilities. We employ the Finite Difference Time Domain Method (FDTD) with the Auxiliary Differential Equation method (ADE) for the calculation of the dispersion relation of the guided modes, as well as the real time propagation suggests that the guiding mechnism in the examined structures is based on the electromagnetic (EM) couping between the slit plasmon modes. These - depending on the design - exist in the grooves between the silver plates or in the larger areas of the glass core spacer. Put it different, the guiding mechanism in the examined SPP waveguide designs is analogous to the EM energy transfer along metallic nanoparticle chains.

  7. Getting Your Period

    MedlinePlus

    ... for a woman to have a baby. During sexual intercourse, the egg can get fertilized by a male’s sperm and then attach to the lining of the uterus ( endometrium ) and grow into a baby. ( Read more about reproduction. ) Does your period come each month? top Menstrual ...

  8. Effect of chronic pallidal deep brain stimulation on off period dystonia and sensory symptoms in advanced Parkinson's disease

    PubMed Central

    Loher, T; Burgunder, J; Weber, S; Sommerhalder, R; Krauss, J

    2002-01-01

    Objective: To investigate the efficacy of chronic pallidal deep brain stimulation (DBS) on off period dystonia, cramps, and sensory symptoms in advanced Parkinson's disease (PD). Methods: 16 patients (6 women, 10 men; mean age at surgery 65 years) suffering from advanced PD were followed up prospectively for one year after implantation of a monopolar electrode in the posteroventral lateral globus pallidus internus. Unilateral DBS was performed in 9 patients. 10 patients had bilateral procedures (contemporaneous bilateral surgery in 7 and staged bilateral surgery in 3 instances). The decision whether to perform unilateral or bilateral surgery depended on the clinical presentation of the patient. Patients were formally assessed preoperatively, at 3–5 days, 3 months, and 12 months after surgery. Results: In patients who underwent unilateral surgery, pain was present in 7 (78%), off dystonia in 5 (56%), cramps in 6 (67%), and dysaesthesia in 4 (44%). In patients who underwent bilateral surgery, pain was present in 7 (70%), off dystonia in 6 (60%), cramps in 7 (70%), and dysaesthesia in 4 (40%). With unilateral DBS, contralateral off period dystonia was improved by 100% at 1 year postoperatively, pain by 74%, cramps by 88%, and dysaesthesia by 100%. There was less pronounced amelioration of ipsilateral off period dystonia and sensory symptoms. With bilateral DBS, total scores for dystonia were improved by 86%, for pain by 90%, for cramps by 90%, and for dysaesthesia by 88%. The benefit appeared early at the first evaluation 3–5 days after surgery and was stable throughout the follow up period. Conclusions: Pallidal DBS yields major improvement of off period dystonia, cramps, and sensory symptoms in patients with advanced PD. PMID:12235307

  9. Periodic minimal surfaces

    NASA Astrophysics Data System (ADS)

    Mackay, Alan L.

    1985-04-01

    A minimal surface is one for which, like a soap film with the same pressure on each side, the mean curvature is zero and, thus, is one where the two principal curvatures are equal and opposite at every point. For every closed circuit in the surface, the area is a minimum. Schwarz1 and Neovius2 showed that elements of such surfaces could be put together to give surfaces periodic in three dimensions. These periodic minimal surfaces are geometrical invariants, as are the regular polyhedra, but the former are curved. Minimal surfaces are appropriate for the description of various structures where internal surfaces are prominent and seek to adopt a minimum area or a zero mean curvature subject to their topology; thus they merit more complete numerical characterization. There seem to be at least 18 such surfaces3, with various symmetries and topologies, related to the crystallographic space groups. Recently, glyceryl mono-oleate (GMO) was shown by Longley and McIntosh4 to take the shape of the F-surface. The structure postulated is shown here to be in good agreement with an analysis of the fundamental geometry of periodic minimal surfaces.

  10. Long period coupling terms for Lagrange's equations

    NASA Technical Reports Server (NTRS)

    1976-01-01

    A generalization of that portion of the work of Berger, which deals with the long period coupling effect of certain pairs of zonal harmonics. Long period terms arising from the short short period coupling of zonal harmonics are derived for Lagrange's equations. The formulation is general so that the results are valid for any pairs of zonal harmonics. Formulas are given to generate the various functions and integrals needed for the results given. Checks have been made against the work of Kozai.

  11. Results of neurolysis in established upper limb Volkmann's ischemic contracture

    PubMed Central

    Meena, Dinesh K; Thalanki, Srikiran; Patni, Poornima; Meena, Ram Khiladi; Bairawa, Dinesh; Bhatia, Chirag

    2016-01-01

    Background: Treatment of established cases of Volkmann's ischemic contracture (VIC) of upper limb is very tedious. Since the period of Volkmann, various experimental works are being performed for its treatment, but none are effective. Disabilities from nerve palsy and hand muscle paralysis are more problematic than any other deformity in VIC. To solve these problems, we conducted a study to see the result of neurolysis of median and ulnar nerve and their subcutaneous placement in established cases of VIC. Materials and Methods: Twelve cases of established VIC operated between July 2007 and August 2010 with complete records and followup were included in the study. VIC of lower limb and contracture of nonischemic etiology were excluded from the study. Their evaluation was done by the British Medical Research Council grading system for sensory and motor recovery. Followup was done for an average period of 24.3 months (range 15-30 months) (the average age was 8.3 years). Results: To study the results, we divided the cases into two series. One group consisted of cases which were operated within 6 months from onset of VIC. The second group consisted of cases which were operated after 6 months from onset of VIC. Our results revealed that there was no statistically significant difference between the two groups operated, though both had significant improvement in motor and sensory recovery in both median and ulnar nerve distribution. Conclusions: Neurolysis of the nerves definitely improved the outcome for motor and sensory components of median and ulnar nerves but the timing of the surgery did not play a role in the outcome contrary to the clinical assumption. This study can serve as a template and further such studies could help us find the answer to a long standing issue. PMID:27904214

  12. Protocol for an investigator-blinded, randomised, 3-month, parallel-group study to compare the efficacy of intraoperative tendon sheath irrigation only with both intraoperative and postoperative irrigation in the treatment of purulent flexor tenosynovitis

    PubMed Central

    Jokihaara, Jarkko; Kaivorinne, Antti; Havulinna, Jouni; Göransson, Harry

    2015-01-01

    Introduction The management of purulent flexor tenosynovitis of the hand consists of surgical debridement followed by antibiotic treatment. Usually, the debridement is carried out by irrigating the tendon sheath in a proximal to distal direction facilitated by two small incisions. It is unclear whether intraoperative irrigation by itself is adequate for healing or if it should be combined with postoperative irrigation in the ward. The hypothesis of this prospective randomised trial is that intraoperative catheter irrigation alone is as effective as a combination of intraoperative and postoperative intermittent catheter irrigation in the treatment of purulent flexor tenosynovitis. Methods and analysis In this investigator-blinded, prospective randomised trial, 48 patients suffering from purulent flexor tenosynovitis are randomised in two groups. Intraoperative catheter irrigation of the flexor tendon sheath and antibiotic treatment is identical in both groups, whereas only the patients in one group are subjected to intermittent postoperative catheter irrigation three times a day for 3 days. The primary outcome measure is total active range of movement of the affected finger after 3 months of surgery. The secondary outcome is the need for reoperation. Ethics and dissemination The research ethics committee of Pirkanmaa Hospital District has approved the study protocol. The protocol has been registered with ClinicalTrials.gov registry (#NCT02320929). All participants will give written informed consent. The study results will elucidate the role of postoperative irrigation, which can be criticised as being labour consuming and unpleasant to the patient. The results of the study will be disseminated as a published article in a peer-reviewed journal. Trial registration number: NCT02320929; pre-results. PMID:26671952

  13. Controls on geyser periodicity.

    PubMed

    Ingebritsen, S E; Rojstaczer, S A

    1993-11-05

    Geyser eruption frequency is not constant over time and has been shown to vary with small (periodicity. Much of the responsiveness to remote seismicity and other small strains in the Earth can be explained in terms of variations in permeability and lateral recharge rates.

  14. Controls on geyser periodicity

    USGS Publications Warehouse

    Ingebritsen, S.E.; Rojstaczer, S.A.

    1993-01-01

    Geyser eruption frequency is not constant over time and has been shown to vary with small (???10-6) strains induced by seismic events, atmospheric loading, and Earth tides. The geyser system is approximated as a permeable conduit of intensely fractured rock surrounded by a less permeable rock matrix. Numerical simulation of this conceptual model yields a set of parameters that controls geyser existence and periodicity. Much of the responsiveness to remote seismicity and other small strains in the Earth can be explained in terms of variations in permeability and lateral recharge rates.

  15. Maternal Dietary Restriction During the Periconceptional Period in Normal-Weight or Obese Ewes Results in Adrenocortical Hypertrophy, an Up-Regulation of the JAK/STAT and Down-Regulation of the IGF1R Signaling Pathways in the Adrenal of the Postnatal Lamb

    PubMed Central

    Zhang, Song; Morrison, Janna L.; Gill, Amreet; Rattanatray, Leewen; MacLaughlin, Severence M.; Kleemann, David; Walker, Simon K.

    2013-01-01

    Maternal dietary restriction during the periconceptional period results in an increase in adrenal growth and in the cortisol stress response in the offspring. The intraadrenal mechanisms that result in the programming of these changes are not clear. Activation of the IGF and the signal transducer and activator of transcription (STAT)/suppressors of cytokine signaling (SOCS) pathways regulate adrenal growth. We have used an embryo transfer model in sheep to investigate the impact of exposure to either dietary restriction in normal or obese mothers or to maternal obesity during the periconceptional period on adrenal growth and function in the offspring. We assessed the adrenal abundance of key signaling molecules in the IGF-I and Janus kinase/STAT/SOCS pathways including IGF-I receptor, IGF-II receptor, Akt, mammalian target of rapamycin, ribosomal protein S6, eukaryotic translation initiation factor 4E-binding protein 1, eukaryotic translation initiation factor 4E, STAT1, STAT3, STAT5, SOCS1, and SOCS3 in female and male postnatal lambs. Maternal dietary restriction in the periconceptional period resulted in the hypertrophy of the adrenocortical cells in the zona fasciculata-reticularis and an up-regulation in STAT1, phospho-STAT1, and phospho-STAT3 (Ser727) abundance and a down-regulation in IGF-I receptor, Akt, and phospho-Akt abundance in the adrenal cortex of the postnatal lamb. These studies highlight that weight loss around the time of conception, independent of the starting maternal body weight, results in the activation of the adrenal Janus kinase/STAT pathway and adrenocortical hypertrophy. Thus, signals of adversity around the time of conception have a long-term impact on the mechanisms that regulate adrenocortical growth. PMID:24108072

  16. Multifunctional periodic cellular metals.

    PubMed

    Wadley, Haydn N G

    2006-01-15

    Periodic cellular metals with honeycomb and corrugated topologies are widely used for the cores of light weight sandwich panel structures. Honeycombs have closed cell pores and are well suited for thermal protection while also providing efficient load support. Corrugated core structures provide less efficient and highly anisotropic load support, but enable cross flow heat exchange opportunities because their pores are continuous in one direction. Recent advances in topology design and fabrication have led to the emergence of lattice truss structures with open cell structures. These three classes of periodic cellular metals can now be fabricated from a wide variety of structural alloys. Many topologies are found to provide adequate stiffness and strength for structural load support when configured as the cores of sandwich panels. Sandwich panels with core relative densities of 2-10% and cell sizes in the millimetre range are being assessed for use as multifunctional structures. The open, three-dimensional interconnected pore networks of lattice truss topologies provide opportunities for simultaneously supporting high stresses while also enabling cross flow heat exchange. These highly compressible structures also provide opportunities for the mitigation of high intensity dynamic loads created by impacts and shock waves in air or water. By filling the voids with polymers and hard ceramics, these structures have also been found to offer significant resistance to penetration by projectiles.

  17. Periodic truss structures

    NASA Astrophysics Data System (ADS)

    Zok, Frank W.; Latture, Ryan M.; Begley, Matthew R.

    2016-11-01

    Despite the recognition of the enormous potential of periodic trusses for use in a broad range of technologies, there are no widely-accepted descriptors of their structure. The terminology has been based loosely either on geometry of polyhedra or of point lattices: neither of which, on its own, has an appropriate structure to fully define periodic trusses. The present article lays out a system for classification of truss structure types. The system employs concepts from crystallography and geometry to describe nodal locations and connectivity of struts. Through a series of illustrative examples of progressively increasing complexity, a rational taxonomy of truss structure is developed. Its conceptual evolution begins with elementary cubic trusses, increasing in complexity with non-cubic and compound trusses as well as supertrusses, and, finally, with complex trusses. The conventions and terminology adopted to define truss structure yield concise yet unambiguous descriptions of structure types and of specific (finite) trusses. The utility of the taxonomy is demonstrated by bringing into alignment a disparate set of ad hoc and incomplete truss designations previously employed in a broad range of science and engineering fields. Additionally, the merits of a particular compound truss (comprising two interpenetrating elementary trusses) is shown to be superior to the octet truss for applications requiring high stiffness and elastic isotropy. By systematically stepping through and analyzing the finite number of structure types identified through the present classification system, optimal structures for prescribed mechanical and functional requirements are expected to be ascertained in an expeditious manner.

  18. A 3-Month, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Ability of an Extra-Strength Marine Protein Supplement to Promote Hair Growth and Decrease Shedding in Women with Self-Perceived Thinning Hair

    PubMed Central

    Ablon, Glynis

    2015-01-01

    An oral marine protein supplement (MPS) is designed to promote hair growth in women with temporary thinning hair (Viviscal Extra Strength; Lifes2good, Inc., Chicago, IL). This double-blind, placebo-controlled study assessed the ability of MPS to promote terminal hair growth in adult women with self-perceived thinning hair associated with poor diet, stress, hormonal influences, or abnormal menstrual cycles. Adult women with thinning hair were randomized to receive MPS (N = 30) or placebo (N = 30) twice daily for 90 days. Digital images were obtained from a 4 cm2 area scalp target area. Each subject's hair was washed and shed hairs were collected and counted. After 90 days, these measures were repeated and subjects completed Quality of Life and Self-Assessment Questionnaires. MPS-treated subjects achieved a significant increase in the number of terminal hairs within the target area (P < 0.0001) which was significantly greater than placebo (P < 0.0001). MPS use also resulted in significantly less hair shedding (P = 0.002) and higher total Self-Assessment (P = 0.006) and Quality of Life Questionnaires scores (P = 0.035). There were no reported adverse events. MPS promotes hair growth and decreases hair loss in women suffering from temporary thinning hair. This trial is registered with ClinicalTrials.gov Identifier: NCT02297360. PMID:25883641

  19. Seismic isolation of two dimensional periodic foundations

    SciTech Connect

    Yan, Y.; Mo, Y. L.; Laskar, A.; Cheng, Z.; Shi, Z.; Menq, F.; Tang, Y.

    2014-07-28

    Phononic crystal is now used to control acoustic waves. When the crystal goes to a larger scale, it is called periodic structure. The band gaps of the periodic structure can be reduced to range from 0.5 Hz to 50 Hz. Therefore, the periodic structure has potential applications in seismic wave reflection. In civil engineering, the periodic structure can be served as the foundation of upper structure. This type of foundation consisting of periodic structure is called periodic foundation. When the frequency of seismic waves falls into the band gaps of the periodic foundation, the seismic wave can be blocked. Field experiments of a scaled two dimensional (2D) periodic foundation with an upper structure were conducted to verify the band gap effects. Test results showed the 2D periodic foundation can effectively reduce the response of the upper structure for excitations with frequencies within the frequency band gaps. When the experimental and the finite element analysis results are compared, they agree well with each other, indicating that 2D periodic foundation is a feasible way of reducing seismic vibrations.

  20. LOG PERIODIC DIPOLE ARRAY WITH PARASITIC ELEMENTS

    DTIC Science & Technology

    The design and measured characteristics of dipole and monopole versions of a log periodic array with parasitic elements are discussed. In a dipole...for the elements to obtain log periodic performance of the anntenna. This design with parasitic elements lends itself to a monopole version of the...antenna which has a simplified feeding configuration. The result is a log periodic antenna design that can be used from high frequencies through microwave frequencies.

  1. Model Valid Prediction Period

    NASA Astrophysics Data System (ADS)

    Chu, P. C.

    2002-12-01

    A new concept, valid prediction period (VPP), is presented here to evaluate model predictability. VPP is defined as the time period when the prediction error first exceeds a pre-determined criterion (i.e., the tolerance level). It depends not only on the instantaneous error growth, but also on the noise level, the initial error, and tolerance level. The model predictability skill is then represented by a single scalar, VPP. The longer the VPP, the higher the model predictability skill is. A theoretical framework on the base of the backward Fokker-Planck equation is developed to determine the probability density function (pdf) of VPP. Verification of a Gulf of Mexico nowcast/forecast model is used as an example to demonstrate the usefulness of VPP. Power law scaling is found in the mean square error of displacement between drifting buoy and model trajectories (both at 50 m depth). The pdf of VPP is asymmetric with a long and broad tail on the higher value side, which suggests long-term predictability. The calculations demonstrate that the long-term (extreme long such as 50-60 day) predictability is not an "outlier" and shares the same statistical properties as the short-term predictions. References Chu P. C., L. M. Ivanov, and C.W. Fan, Backward Fokker-Plank equation for determining model predictability with unknown initial error distribution. J. Geophys. Res., in press, 2002. Chu P.C., L.M.Ivanov, T.M. Margolina, and O.V.Melnichenko, 2002b: On probabilistic stability of an atmospheric model to various amplitude perturbations. J. Atmos. Sci., in press Chu P.C., L.M. Ivanov, L. Kantha, O.V. Melnichenko and Y.A. Poberezhny, 2002c: The long-term correlations and power decay law in model prediction skill. Geophys. Res. Let., in press.

  2. Incidence of double ovulation during the early postpartum period in lactating dairy cows.

    PubMed

    Kusaka, Hiromi; Miura, Hiroshi; Kikuchi, Motohiro; Sakaguchi, Minoru

    2017-03-15

    In lactating cattle, the incidence of twin calving has many negative impacts on production and reproduction in dairy farming. In almost all cases, natural twinning in dairy cattle is the result of double ovulation. It has been suggested that the milk production level of cows influences the number of ovulatory follicles. The objective of the present study was to investigate the incidence of double ovulations during the early postpartum period in relation to the productive and reproductive performance of dairy cows. The ovaries of 43 Holstein cows (26 primiparous and 17 multiparous) were ultrasonographically scanned throughout the three postpartum ovulation sequences. The incidence of double ovulation in the unilateral ovaries was 66.7%, with a higher incidence in the right ovary than in the left, whereas that in bilateral ovaries was 33.3%. When double ovulations were counted dividing into each side ovary in which ovulations occurred, the total frequency of ovulations deviated from a 1:1 ratio (60.3% in the right side and 39.7% in the left side, P < 0.05). In multiparous cows, double ovulation occurred more frequently than in primiparous cows (58.8% vs. 11.5% per cow and 30.0% vs. 3.8% per ovulation, respectively P < 0.01). The double ovulators experienced more anovulatory repeated waves of follicles before their first ovulations than the single ovulators, which resulted in an extension of the period from parturition to third ovulation (81.5 days vs. 64.2 days, P < 0.05). In the multiparous cows, the double ovulators exhibited higher peak milk yield (P < 0.01) with lower milk lactose concentration (P < 0.05), indicating the prevalence of a more severe negative energy balance during the postpartum 3-month compared to the multiparous single ovulators. Our results showed that, regardless of their parity, double ovulation had no impact on the reproductive performance of the cows. Two multiparous cows that experienced double ovulation during the early

  3. Matter-wave exact periodic solutions in optical lattices with periodic potential

    NASA Astrophysics Data System (ADS)

    Liu, Changfu; Zhu, Aijun

    2013-10-01

    Some special matter-wave periodic solutions for the Gross-Pitaevskii equation with periodic potential in the multidimensional optical lattices, are obtained through restricting parameters and some balance conditions between the optical potentials and interaction energies. The results show that the same type of periodic solutions in the same dimension possesses the same norm but different phases and they are all bounded. Especially, the numerics shows that two class (2+1)-dimensional periodic solutions are stable.

  4. [Childhood periodic syndromes].

    PubMed

    Cuvellier, J-C; Lépine, A

    2010-01-01

    This review focuses on the so-called "periodic syndromes of childhood that are precursors to migraine", as included in the Second Edition of the International Classification of Headache Disorders. Three periodic syndromes of childhood are included in the Second Edition of the International Classification of Headache Disorders: abdominal migraine, cyclic vomiting syndrome and benign paroxysmal vertigo, and a fourth, benign paroxysmal torticollis is presented in the Appendix. The key clinical features of this group of disorders are the episodic pattern and intervals of complete health. Episodes of benign paroxysmal torticollis begin between 2 and 8 months of age. Attacks are characterized by an abnormal inclination and/or rotation of the head to one side, due to cervical dystonia. They usually resolve by 5 years. Benign paroxysmal vertigo presents as sudden attacks of vertigo, accompanied by inability to stand without support, and lasting seconds to minutes. Age at onset is between 2 and 4 years, and the symptoms disappear by the age of 5. Cyclic vomiting syndrome is characterized in young infants and children by repeated stereotyped episodes of pernicious vomiting, at times to the point of dehydration, and impacting quality of life. Mean age of onset is 5 years. Abdominal migraine remains a controversial issue and presents in childhood with repeated stereotyped episodes of unexplained abdominal pain, nausea and vomiting occurring in the absence of headache. Mean age of onset is 7 years. Both cyclic vomiting syndrome and abdominal migraine are noted for the absence of pathognomonic clinical features but also for the large number of other conditions to be considered in their differential diagnoses. Diagnostic criteria, such as those of the Second Edition of the International Classification of Headache Disorders and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, have made diagnostic approach and management easier. Their diagnosis

  5. Bilingual Children with Primary Language Impairment: 3 Months after Treatment

    ERIC Educational Resources Information Center

    Pham, Giang; Ebert, Kerry Danahy; Kohnert, Kathryn

    2015-01-01

    Background: Evidence on the treatment effectiveness for bilingual children with primary language impairment (PLI) is needed to advance both theory and clinical practice. Of key interest is whether treatment effects are maintained following the completion of short-term intense treatments. Aims: To investigate change in select language and cognitive…

  6. Senses and Your 1- to 3-Month-Old

    MedlinePlus

    ... baby's toes or fingers. Introduce different textures and temperatures: the softness of a feather, the hardness of ... questions: Does the baby startle at an unexpected sound? Does the baby respond to the sound of ...

  7. Selecting Full-Text Undergraduate Periodicals Databases.

    ERIC Educational Resources Information Center

    Still, Julie M.; Kassabian, Vibiana

    1999-01-01

    Examines how libraries and librarians can compare full-text general periodical indices, using ProQuest Direct, Periodical Abstracts (via Ovid), and EBSCOhost as examples. Explores breadth and depth of coverage; manipulation of results (email/download/print); ease of use (searching); and indexing quirks. (AEF)

  8. NONPARAMETRIC BAYESIAN ESTIMATION OF PERIODIC LIGHT CURVES

    SciTech Connect

    Wang Yuyang; Khardon, Roni; Protopapas, Pavlos

    2012-09-01

    Many astronomical phenomena exhibit patterns that have periodic behavior. An important step when analyzing data from such processes is the problem of identifying the period: estimating the period of a periodic function based on noisy observations made at irregularly spaced time points. This problem is still a difficult challenge despite extensive study in different disciplines. This paper makes several contributions toward solving this problem. First, we present a nonparametric Bayesian model for period finding, based on Gaussian Processes (GPs), that does not make assumptions on the shape of the periodic function. As our experiments demonstrate, the new model leads to significantly better results in period estimation especially when the light curve does not exhibit sinusoidal shape. Second, we develop a new algorithm for parameter optimization for GP which is useful when the likelihood function is very sensitive to the parameters with numerous local minima, as in the case of period estimation. The algorithm combines gradient optimization with grid search and incorporates several mechanisms to overcome the high computational complexity of GP. Third, we develop a novel approach for using domain knowledge, in the form of a probabilistic generative model, and incorporate it into the period estimation algorithm. Experimental results validate our approach showing significant improvement over existing methods.

  9. The Stability of Maternal Interpretation of Infant's Facial Expressions during Pre- and Postnatal Period and Its Relation to Prenatal Attachment.

    ERIC Educational Resources Information Center

    Siddiqui, Anver; Eisemann, Martin; Hagglof, Bruno

    2000-01-01

    Projective methods were used to explore maternal perception and interpretation of infant's emotional expressions during the third trimester of pregnancy and 3 months postpartum. Results revealed that mothers interpreted infant emotions overwhelmingly in positive terms at both times; findings suggest consistency in maternal interpretation across…

  10. Oats in the diet of children with celiac disease: preliminary results of a double-blind, randomized, placebo-controlled multicenter Italian study.

    PubMed

    Gatti, Simona; Caporelli, Nicole; Galeazzi, Tiziana; Francavilla, Ruggiero; Barbato, Maria; Roggero, Paola; Malamisura, Basilio; Iacono, Giuseppe; Budelli, Andrea; Gesuita, Rosaria; Catassi, Carlo; Lionetti, Elena

    2013-11-20

    A gluten-free diet (GFD) is currently the only available treatment for patients with celiac disease (CD). Several clinical trials have demonstrated that most celiac patients can tolerate a medium-high quantity of oats without any negative clinical effects; however, the inclusion of oats in GFD is still a matter of debate. In this study, Italian children with CD were enrolled in a 15-month, randomized, double-blind, placebo-controlled multicenter trial. Participants were randomized in two groups following either A-B treatment (6 months of diet "A", 3 months of standard GFD, 6 months of diet "B"), or B-A treatment (6 months of diet "B", 3 months of standard GFD, 6 months of diet "A"). A and B diets included gluten-free (GF) products (flour, pasta, biscuits, cakes and crisp toasts) with either purified oats or placebo. Clinical data (Gastrointestinal Symptoms Rate Scale [GSRS] score) and intestinal permeability tests (IPT), were measured through the study period. Although the study is still blinded, no significant differences were found in GSRS score or the urinary lactulose/mannitol (L/M) ratio between the two groups after 6 months of treatment. These preliminary results suggest that the addition of non-contaminated oats from selected varieties in the treatment of children with CD does not determine changes in intestinal permeability and gastrointestinal symptoms.

  11. Tissue integration of one-stage implants: three-year results of a prospective longitudinal study with hollow cylinder and hollow screw implants.

    PubMed

    Buser, D; Weber, H P; Brägger, U; Balsiger, C

    1994-10-01

    Tissue integration of one-stage, nonsubmerged ITI implants over a 5-year period is documented. Fifty-four implants were placed in 38 partially edentulous patients. No implants had detectable mobility after a healing phase of at least 3 months, and there were no clinical signs of peri-implant infection. Radiographs revealed no peri-implant radiolucencies and all implants were in favorable positions for fixed prosthetic restorations. Following completion of the prosthetic treatment, all patients were placed in 3-month oral hygiene recall programs. Annual dental examinations included evaluation of each implant according to fixed criteria. Three years after implant placement, 51 of 53 implants (96.2%) were evaluated as successful (one patient was lost to the study). Acute peri-implant infections were associated with two implants; both were classified as late failures. The results demonstrated that one-stage transgingivally healing ITI implants integrate dependably in the tissue and that successful tissue integration can be maintained for at least 3 years.

  12. Treatment of bronchial asthma with low-level laser in attack-free period at children

    NASA Astrophysics Data System (ADS)

    Ailioaie, C.; Ailioaie, Laura

    2000-06-01

    Bronchial asthma is a common disease in both the pediatric and adult populations, characterized by wide variations over short periods of time in resistance to airflow in intrapulmonary airways. A primary goal in the use of low- level laser therapy (LLLT) was the safe, effective and rapid palliation of symptoms owing to tracheal or bronchial obstruction. We have investigated the effects of LLLT comparatively with other modality trials in children's asthma. In the study were included 98 patients aged 10-18 years diagnosed with moderate or severe asthma, in attack- free period. The patients were divided into 3 groups. Group 1 received only laser therapy using extra meridian acupuncture points and scanning technique. Group 2 was treated only with inhaled Serevent 2 X 25 micrometers , two times daily, 3 months. Group 3 was tread with Theophylline retard in dosage of 15-mg/kg/12 h, 3 months. At the end of treatment we remarked a noticeable improvement of the clinical, functional and immunological characteristics at 83 percent of patients in group 1, comparatively with only 70 percent (group 2) and 53 percent (group 3). The LLLT had a very good action on bronchial patency , displayed an immunocorrecting action and is recommended in attack-free periods at children.

  13. [Hearing screening of newborns. Preliminary results].

    PubMed

    Courtmans, I; Mancilla, V; Ligny, C; Belhadi, B; Damis, E; Mahillon, P

    2005-02-01

    Since 1976, an hearing screening is organized at the Clinic Edith Cavell. The testing was based on a behavioral technique of Veit-Bizaguet and, since 2001, the otoacoustic emissions are realised. The National Institutes of Health (1993) recommends universal newborn hearing screening of all newborns before 3 months of age and identification and treatment before 6 months of age. Indeed, detection of hearing loss and early intervention allow a better access to the language and consequently an easier schooling and social integration. This article shows the results of the screening from february at the end of December 2002. These data are compared with those of the literature.

  14. Ocular changes resulting from therapy with amiodarone.

    PubMed Central

    Ingram, D V; Jaggarao, N S; Chamberlain, D A

    1982-01-01

    Amiodarone, a powerful antiarrhythmic agent recently made available in Britain, is known to cause corneal changes, but the clinical implications of this unwanted effect are still controversial. We have made serial observations on 105 patients treated with the drug for periods ranging from 3 months to over 7 years. Corneal abnormalities were detected by slit-lamp examination in 103 patients (98%). These always progressed over several months but subsequently showed a stable pattern which changed only with alteration of dose. The abnormalities regressed and disappeared within 7 months in the 16 patients whose treatment was discontinued for reasons unconnected with ocular changes. No macular changes or permanent sequelae occurred. Ocular symptoms were unusual: 6 patients had reactions in the skin of the eyelids, and 6 others had minor symptoms related to the corneal changes. We do not believe that ophthalmological surveillance is mandatory in asymptomatic patients on long-term amiodarone therapy. Images PMID:7115651

  15. Nonlinear growth of periodic patterns.

    PubMed

    Villain-Guillot, Simon; Josserand, Christophe

    2002-09-01

    We study the growth of a periodic pattern in one dimension for a model of spinodal decomposition, the Cahn-Hilliard equation. We particularly focus on the intermediate region, where the nonlinearity cannot be neglected anymore, and before the coalescence dominates. The dynamics is captured through the standard technique of a solubility condition performed over a particular family of quasistatic solutions. The main result is that the dynamics along this particular class of solutions can be expressed in terms of a simple ordinary differential equation. The density profile of the stationary regime found at the end of the nonlinear growth is also well characterized. Numerical simulations correspond satisfactorily to the analytical results through three different methods and asymptotic dynamics are well recovered, even far from the region where the approximations hold.

  16. Rotational period of GQ Lupi

    NASA Astrophysics Data System (ADS)

    Broeg, C.; Schmidt, T. O. B.; Guenther, E.; Gaedke, A.; Bedalov, A.; Neuhäuser, R.; Walter, F. M.

    2007-06-01

    Aims: We wanted to determine the rotation parameters of GQ Lup A, thereby constraining the evolutionary history of the GQ Lup system. Methods: We have undertaken a photometric monitoring campaign on GQ Lup A consisting of two epochs spaced one year apart. We also searched the photometric archives to enlarge the data set. Results: We were able to determine the photometric period (8.45±0.2 days) in both epochs in several photometric bands. This periodicity could also be found in some of the archival data. The combined false-alarm probability is 0.015. The variation is most likely caused by hot spots on the surface of GQ Lup A. This, combined with high-resolution spectra (v sin i) allows calculation of GQ Lup A's inclination (i=27±5°). Radial velocity data also contains this period but is inconclusive. Nevertheless, the RV data supports the interpretation that hot spots cause the photometric variation. We use the known K-band variability, amplitude, and phase of GQ Lup A together with a new image of GQ Lup A+b, taken quasi-simultaneously with our monitoring of the star, to confirm the magnitude and, hence, luminosity of the companion. Based on observations obtained on Cerro Paranal, Chile, in ESO program 075.C-0710(C) and on La Silla, Chile, in ESO programs 074.C-0034(A),075.C-0710(E), 075.C-0710(F), 075.C-0202(A), 076.C-0010(A) as well as with ANDICAM of the SMARTS consortium. Photometry data of epochs I and II are only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/468/1039

  17. The redoubtable ecological periodic table

    EPA Science Inventory

    Ecological periodic tables are repositories of reliable information on quantitative, predictably recurring (periodic) habitat–community patterns and their uncertainty, scaling and transferability. Their reliability derives from their grounding in sound ecological principle...

  18. Doubly Resonant Optical Periodic Structure

    PubMed Central

    Alagappan, G.; Png, C. E.

    2016-01-01

    Periodic structures are well known in various branches of physics for their ability to provide a stopband. In this article, using optical periodic structures we showed that, when a second periodicity – very closed to the original periodicity is introduced, large number of states appears in the stopband corresponding to the first periodicity. In the limit where the two periods matches, we have a continuum of states, and the original stopband completely disappears. This intriguing phenomena is uncovered by noticing that, regardless of the proximities of the two periodicities, there is an array of spatial points where the dielectric functions corresponding to the two periodicities interfere destructively. These spatial points mimic photonic atoms by satisfying the standards equations of quantum harmonic oscillators, and exhibit lossless, atom-like dispersions. PMID:26853945

  19. Doubly Resonant Optical Periodic Structure.

    PubMed

    Alagappan, G; Png, C E

    2016-02-08

    Periodic structures are well known in various branches of physics for their ability to provide a stopband. In this article, using optical periodic structures we showed that, when a second periodicity--very closed to the original periodicity is introduced, large number of states appears in the stopband corresponding to the first periodicity. In the limit where the two periods matches, we have a continuum of states, and the original stopband completely disappears. This intriguing phenomena is uncovered by noticing that, regardless of the proximities of the two periodicities, there is an array of spatial points where the dielectric functions corresponding to the two periodicities interfere destructively. These spatial points mimic photonic atoms by satisfying the standards equations of quantum harmonic oscillators, and exhibit lossless, atom-like dispersions.

  20. 76 FR 297 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... 39 CFR Part 3050 Periodic Reporting AGENCY: Postal Regulatory Commission. ACTION: Notice of proposed... a proposed change in certain analytical methods used in periodic reporting. This action responds to... proceeding to consider changes in the analytical methods approved for use in periodic reporting.\\1\\...

  1. 75 FR 1301 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-11

    ... 39 CFR Part 3050 Periodic Reporting AGENCY: Postal Regulatory Commission. ACTION: Proposed rule... rulemaking proceeding to consider changes in the analytical methods approved for use in periodic reporting.\\1... Docket No. RM2009-10, Order on Analytical Principles Used in Periodic Reporting (Proposals Three...

  2. Assessment of Precipitation and Drought Variability in Weihe River of China Over the Period 1960-2010

    NASA Astrophysics Data System (ADS)

    Chang, J.; Wang, Y.

    2015-12-01

    The amount and distribution of precipitation play crucial roles in the occurrence of drought in the Weihe River Basin (WRB) of China. Using the precipitation data (1960-2010) of 21 meteorological stations, the spatial and temporal characteristics of droughts were examined by using theory of runs and the Standardized Precipitation Index on 3-month, 6-month and 12-month time scales. The results showed that the main drought type was moderate drought, and drought occurred frequently on July and October. During the last 50 years, the drought intensity and frequency were the biggest in 1991-2000. According to the SPI-3, the risk of spring and fall drought increased gradually, which could impact on agriculture and water supply. The trend of SPI values over the time period was calculated and analyzed, showing of increasing dryness throughout the basin, and the north and northwest zones of WRB were most likely to suffer from drought. Also, compared with the east, the drought severity and drought duration in the northwest was more serious. It was also observed that there was strong relation between precipitation distribution and drought zones in the basin, and the drought conditions changed continuously with seasons depending upon precipitation amount and its spatial distribution.

  3. Numerical Continuation of Hamiltonian Relative Periodic Orbits

    NASA Astrophysics Data System (ADS)

    Wulff, Claudia; Schebesch, Andreas

    2008-08-01

    The bifurcation theory and numerics of periodic orbits of general dynamical systems is well developed, and in recent years, there has been rapid progress in the development of a bifurcation theory for dynamical systems with structure, such as symmetry or symplecticity. But as yet, there are few results on the numerical computation of those bifurcations. The methods we present in this paper are a first step toward a systematic numerical analysis of generic bifurcations of Hamiltonian symmetric periodic orbits and relative periodic orbits (RPOs). First, we show how to numerically exploit spatio-temporal symmetries of Hamiltonian periodic orbits. Then we describe a general method for the numerical computation of RPOs persisting from periodic orbits in a symmetry breaking bifurcation. Finally, we present an algorithm for the numerical continuation of non-degenerate Hamiltonian relative periodic orbits with regular drift-momentum pair. Our path following algorithm is based on a multiple shooting algorithm for the numerical computation of periodic orbits via an adaptive Poincaré section and a tangential continuation method with implicit reparametrization. We apply our methods to continue the famous figure eight choreography of the three-body system. We find a relative period doubling bifurcation of the planar rotating eight family and compute the rotating choreographies bifurcating from it.

  4. Periodic Wake Effects on Turbulent Juncture Flows

    NASA Astrophysics Data System (ADS)

    Sabatino, Daniel; Smith, Charles

    2000-11-01

    The horseshoe vortex (HV) that develops in juncture geometries with a turbulent approach flow has been shown to exhibit a periodic behavior that correlates with the bursting frequency of the impinging turbulent boundary layer. To examine the additional complication of impinging blade wakes on such juncture flows, as encountered in turbomachinery environments, periodic wakes were systematically introduced upstream of a simple turbulent endwall juncture flow. The influence of the wakes was examined via a study of the instantaneous endwall surface heat transfer behavior, established using an experimental liquid crystal technique in a water channel. Although it is possible to eliminate the periodic HV behavior using periodic wakes of high frequency (relative to the HV frequency) or strong turbulence intensity, the periodic character of the undisturbed HV remains evident at or below moderate wake frequency and turbulence levels. A parametric assessment of the results suggests that the periodic wake effects encountered for a real gas turbine cascade would not eliminate the HV periodicity. The significance of this residual HV periodicity on the endwall surface heat transfer will be discussed.

  5. Percutaneous endoscopic lumbar discectomy: Results of first 100 cases

    PubMed Central

    Mahesha, Kanthila

    2017-01-01

    Background: Lumbar disc herniation is a major cause of back pain and sciatica. The surgical management of lumbar disc prolapse has evolved from exploratory laminectomy to percutaneous endoscopic discectomy. Percutaneous endoscopic discectomy is the least invasive procedure for lumbar disc prolapse. The aim of this study was to analyze the clinical outcome, quality of life, neurologic function, and complications. Materials and Methods: One hundred patients with lumbar disc prolapse who were treated with percutaneous endoscopic discectomy from May 2012 to January 2014 were included in this retrospective study. Clinical followup was done at 1 month, 3 months, 6 months, 1 year, and at yearly interval thereafter. The outcome was assessed using modified Macnab's criteria, visual analog scale, and Oswestry Disability Index. Results: The mean followup period was 2 years (range 18 months - 3 years). Transforaminal approach was used in 84 patients, interlaminar approach in seven patients, and combined approach in nine patients. An excellent outcome was noted in ninety patients, good outcome in six patients, fair result in two patients, and poor result in two patients. Minor complications were seen in three patients, and two patients had recurrent disc prolapse. Mean hospital stay was 1.6 days. Conclusions: Percutaneous endoscopic lumbar discectomy is a safe and effective procedure in lumbar disc prolapse. It has the advantage that it can be performed on a day care basis under local anesthesia with shorter length of hospitalization and early return to work thus improving the quality of life earlier. The low complication rate makes it the future of disc surgery. Transforaminal approach alone is sufficient in majority of cases, although 16% of cases required either percutaneous interlaminar approach or combined approach. The procedure definitely has a learning curve, but it is acceptable with adequate preparations. PMID:28216749

  6. A periodic table for cancer.

    PubMed

    Epstein, Richard J

    2015-01-01

    Cancers exhibit differences in metastatic behavior and drug sensitivity that correlate with certain tumor-specific variables such as differentiation grade, growth rate/extent and molecular regulatory aberrations. In practice, patient management is based on the past results of clinical trials adjusted for these biomarkers. Here, it is proposed that treatment strategies could be fine-tuned upfront simply by quantifying tumorigenic spatial (cell growth) and temporal (genetic stability) control losses, as predicted by genetic defects of cell-cycle-regulatory gatekeeper and genome-stabilizing caretaker tumor suppressor genes, respectively. These differential quantifications of tumor dysfunction may in turn be used to create a tumor-specific 'periodic table' that guides rational formulation of survival-enhancing anticancer treatment strategies.

  7. Periodic power spectrum with applications in detection of latent periodicities in DNA sequences.

    PubMed

    Yin, Changchuan; Wang, Jiasong

    2016-11-01

    Periodic elements play important roles in genomic structures and functions, yet some complex periodic elements in genomes are difficult to detect by conventional methods such as digital signal processing and statistical analysis. We propose a periodic power spectrum (PPS) method for analyzing periodicities of DNA sequences. The PPS method employs periodic nucleotide distributions of DNA sequences and directly calculates power spectra at specific periodicities. The magnitude of a PPS reflects the strength of a signal on periodic positions. In comparison with Fourier transform, the PPS method avoids spectral leakage, and reduces background noise that appears high in Fourier power spectrum. Thus, the PPS method can effectively capture hidden periodicities in DNA sequences. Using a sliding window approach, the PPS method can precisely locate periodic regions in DNA sequences. We apply the PPS method for detection of hidden periodicities in different genome elements, including exons, microsatellite DNA sequences, and whole genomes. The results show that the PPS method can minimize the impact of spectral leakage and thus capture true hidden periodicities in genomes. In addition, performance tests indicate that the PPS method is more effective and efficient than a fast Fourier transform. The computational complexity of the PPS algorithm is [Formula: see text]. Therefore, the PPS method may have a broad range of applications in genomic analysis. The MATLAB programs for implementing the PPS method are available from MATLAB Central ( http://www.mathworks.com/matlabcentral/fileexchange/55298 ).

  8. Optimising prescription and titration of oxygen for adult inpatients using novel silicone wristbands: results of a pilot project at three centres.

    PubMed

    Forster, Sarah; Smith, Sue; Daniel, Priya; Binnion, Amy; Briggs, Lucy; Evans, Rachel; Ryanna, Kimuli; Woltmann, Gerrit; Bajammal, Omar; Hodgson, David; Saini, Gauri; Scullion, Jane; Bolton, Charlotte E; Lowrey, Gillian

    2016-08-01

    Oxygen is the most commonly used drug in the acute hospital setting. Oxygen can be lifesaving but there is increasing evidence that it can cause harm if it is not given correctly. Prescription of oxygen, according to target saturations, has been advocated since 2008 but compliance remains at low levels. This paper describes a novel approach to improve oxygen prescription and titration in three acute hospital trusts using a colour-coded silicone wristband. The project ran for 3 months and covered more than 2,000 emergency admissions to hospital. Data was collected for oxygen prescription and titration rates for 270 patients during the project period. The wristbands showed an improvement in prescription and titration of oxygen in two out of three sites. The results support a wider controlled study of colour-coded wristbands to improve oxygen safety in secondary care.

  9. Investigation on Periodically Surface-Corrugated Long-Period Gratings Inscribed on Photonic Crystal Fibers.

    PubMed

    Han, Young-Geun

    2017-12-01

    Transmission characteristics of periodically surface-corrugated long-period gratings (LPGs) inscribed on photonic crystal fibers (PCFs) using a wet-etching technique were experimentally investigated. A conventional wet method was implemented to periodically engrave the silica cladding region of the PCFs resulting in the periodic surface corrugation in the PCF. After applying the external strain to the PCF with the periodic surface micro-ridges, periodic modulation of refractive index based on the photoelastic effect is induced resulting in the formation of the PCF-based LPG. Increasing the applied strain successfully improves the extinction ratio of the resonant peak of the PCF-based LPG without the resonant wavelength shift. We also measured the transmission characteristics of the PCF-based LPG with variations in temperature and ambient index.

  10. Periodicity of extinction: A 1988 update

    NASA Technical Reports Server (NTRS)

    Sepkowski, J. John, Jr.

    1988-01-01

    The hypothesis that events of mass extinction recur periodically at approximately 26 my intervals is an empirical claim based on analysis of data from the fossil record. The hypothesis has become closely linked with catastrophism because several events in the periodic series are associated with evidence of extraterrestrial impacts, and terrestrial forcing mechanisms with long, periodic recurrences are not easily conceived. Astronomical mechanisms that have been hypothesized include undetected solar companions and solar oscillation about the galactic plane, which induce comet showers and result in impacts on Earth at regular intervals. Because these mechanisms are speculative, they have been the subject of considerable controversy, as has the hypothesis of periodicity of extinction. In response to criticisms and uncertainties, a data base was developed on times of extinction of marine animal genera. A time series is given and analyzed with 49 sample points for the per-genus extinction rate from the Late Permian to the Recent. An unexpected pattern in the data is the uniformity of magnitude of many of the periodic extinction events. Observations suggest that the sequence of extinction events might be the result of two sets of mechanisms: a periodic forcing that normally induces only moderate amounts of extinction, and independent incidents or catastrophes that, when coincident with the periodic forcing, amplify its signal and produce major-mass extinctions.

  11. Effect of biostimulation on the microbial community in PCB-contaminated sediments through periodic amendment of sediment with iron.

    PubMed

    Srinivasa Varadhan, A; Khodadoust, Amid P; Brenner, Richard C

    2011-10-01

    Reductive dehalogenation of polychlorinated biphenyls (PCBs) by indigenous dehalorespiring microorganisms in contaminated sediments may be enhanced via biostimulation by supplying hydrogen generated through the anaerobic corrosion of elemental iron added to the sediment. In this study, the effect of periodic amendment of sediment with various dosages of iron on the microbial community present in sediment was investigated using phospholipid fatty acid analysis (PLFA) over a period of 18 months. Three PCB-contaminated sediments (two freshwater lake sediments and one marine sediment) were used. Signature biomarker analysis of the microbial community present in all three sediments revealed the enrichment of Dehalococcoides species, the population of which was sustained for a longer period of time when the sediment microcosms were amended with the lower dosage of iron (0.01 g iron per g dry sediment) every 6 months as compared to the blank system (without iron). Lower microbial stress levels were reported for the system periodically amended with 0.01 g of iron per g dry sediment every 6 months, thus reducing the competition from other hydrogen-utilizing microorganisms like methanogens, iron reducers, and sulfate reducers. The concentration of hydrogen in the system was found to be an important factor influencing the shift in microbial communities in all sediments with time. Periodic amendment of sediment with larger dosages of iron every 3 months resulted in the early prevalence of Geobacteraceae and sulfate-reducing bacteria followed by methanogens. An average pH of 8.4 (range of 8.2-8.6) and an average hydrogen concentration of 0.75% (range of 0.3-1.2%) observed between 6 and 15 months of the study were found to be conducive to sustaining the population of Dehalococcoides species in the three sediments amended with 0.01 g iron per g dry sediment. Biostimulation of indigenous PCB dechlorinators by the periodic amendment of contaminated sediments with low dosages of

  12. Subjective results of joint lavage and viscosupplementation in hemophilic arthropathy

    PubMed Central

    de Rezende, Márcia Uchoa; Rosa, Thiago Bittencourt Carvalho; Pasqualin, Thiago; Frucchi, Renato; Okazaki, Erica; Villaça, Paula Ribeiro

    2015-01-01

    OBJECTIVE: To assess whether joint lavage, viscosupplementation and triamcinolone improve joint pain, function and quality of life in patients with severe hemophilic arthropathy. METHODS: Fourteen patients with knee and/or ankle hemophilic arthritis with and without involvement of other joints underwent joint lavage and subsequent injection of hylan G-F20 and triamcinolone in all affected joints. The patients answered algo-functional questionnaires (Lequesne and WOMAC), visual analog scale for pain (VAS) and SF-36 preoperatively, and at one, three, six and twelve months postoperatively. RESULTS: Sixteen knees, 15 ankles, 8 elbows and one shoulder were treated in 14 patients. Six patients had musculoskeletal bleeding [ankle (1), leg muscle (2) and knees (4)] at 3 months affecting the results. Pain did not improve significantly. Function improved (WOMAC p=0.02 and Lequesne p=0.01). The physical component of SF-36 improved at all time points except at 3 months, with best results at one-year follow-up (baseline = 33.4; 1 month = 39.6; 3 months= 37.6; 6 months 39.6 and 1 year = 44.6; p < 0.001). CONCLUSION: Joint lavage followed by injection of triamcinolone and hylan G-F20 improves function and quality of life progressively up to a year, even in severe hemophilic arthropathy. Level of Evidence IV, Case Series. PMID:26207096

  13. Kepler K2 Precision Lightcurve Observations of Pluto: Preliminary Results

    NASA Astrophysics Data System (ADS)

    Lisse, Casey M.; Benecchi, Susan D.; Binzel, Richard; Schwamb, Megan Elizabeth; New Horizons Science Team

    2016-10-01

    Pluto is a key object in the third zone of our Solar System and provides important insight into formation and collisional processes that were at work in the early solar system. In July 2015 the New Horizons spacecraft successfully obtained high resolution fly-by clear filter imaging observations of the Pluto system. We report on our continued monitoring of the Pluto system from October-December 2015 using the Kepler spacecraft's imaging photometer during Campaign 7 of the K2 extended mission (Howell et al. 2014). We obtained an unprecedented 83-day nearly continuous lightcurve with measurements every 30 minutes using Kepler's long cadence sampling. The result was 3,980 discrete, unresolved measurements of the combined Pluto system. The 3-month baseline allowed us to sample rotational variations and solar phase angles ranging from 1.1°-1.7° during the period of observation. This dataset is a key baseline for advancing the study of Pluto's actively evolving surface-atmosphere interaction as revealed by the surface geomorphology discovered by New Horizons. Our challenge is to gain an understanding of the ways in which Pluto's surface can be evolving as it recedes from the Sun, and of the influence of Pluto and Charon on each other. In this paper, we present our preliminary results from our K2 dataset. We describe the challenges in reducing the K2 lightcurve data for a target moving across the K2 FOV, and our progress in understanding the lightcurve's variability, which in our current reduction is due to a combination of systematics in the K2 dataset and inherent characteristics of the Pluto system's rotation and changing orbital geometry wrt the Sun and the Earth.This work was supported by NASA's K2 and New Horizons missions.

  14. From Periodic Properties to a Periodic Table Arrangement

    ERIC Educational Resources Information Center

    Besalú, Emili

    2013-01-01

    A periodic table is constructed from the consideration of periodic properties and the application of the principal components analysis technique. This procedure is useful for objects classification and data reduction and has been used in the field of chemistry for many applications, such as lanthanides, molecules, or conformers classification.…

  15. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and...

  16. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2013-04-01 2013-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and...

  17. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2011-04-01 2011-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and...

  18. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2012-04-01 2012-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and...

  19. 24 CFR 203.266 - Period covered by periodic MIP.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... HOUSING AND URBAN DEVELOPMENT MORTGAGE AND LOAN INSURANCE PROGRAMS UNDER NATIONAL HOUSING ACT AND OTHER... 24 Housing and Urban Development 2 2014-04-01 2014-04-01 false Period covered by periodic MIP. 203.266 Section 203.266 Housing and Urban Development Regulations Relating to Housing and...

  20. Reliability, return periods, and risk under nonstationarity

    NASA Astrophysics Data System (ADS)

    Read, Laura K.; Vogel, Richard M.

    2015-08-01

    Water resources design has widely used the average return period as a concept to inform management and communication of the risk of experiencing an exceedance event within a planning horizon. Even though nonstationarity is often apparent, in practice hydrologic design often mistakenly assumes that the probability of exceedance, p, is constant from year to year which leads to an average return period To equal to 1/p; this expression is far more complex under nonstationarity. Even for stationary processes, the common application of an average return period is problematic: it does not account for planning horizon, is an average value that may not be representative of the time to the next flood, and is generally not applied in other areas of water planning. We combine existing theoretical and empirical results from the literature to provide the first general, comprehensive description of the probabilistic behavior of the return period and reliability under nonstationarity. We show that under nonstationarity, the underlying distribution of the return period exhibits a more complex shape than the exponential distribution under stationary conditions. Using a nonstationary lognormal model, we document the increased complexity and challenges associated with planning for future flood events over a planning horizon. We compare application of the average return period with the more common concept of reliability and recommend replacing the average return period with reliability as a more practical way to communicate event likelihood in both stationary and nonstationary contexts.

  1. Late results.

    PubMed

    Daly, B D

    1999-08-01

    Pneumonectomy is performed for a number of benign and malignant conditions. It is most commonly performed for lung cancer. Adjuvant and neoadjuvant protocols have increased the number of these operations being performed and the long-term results are improving. Pneumonectomy may also be performed for metastases to lung and for mesothelioma with encouraging results. Some bronchial adenomas require pneumonectomy. Treatment of resistant mycobacteria or the complications of tuberculosis frequently require pneumonectomy. Late bronchopleural fistulae, esophagopleural fistulae, and empyema may occur.

  2. Robust increase in concurrent hot and dry periods at the global scale

    NASA Astrophysics Data System (ADS)

    Zscheischler, Jakob; Seneviratne, Sonia I.

    2016-04-01

    Ongoing climate change is largely affecting the frequency and magnitude of climate extremes in many areas of the world. Most studies investigating extreme events focus on a single variable such as, for instance, extreme temperature, drought, and heavy precipitation. Often, however, it is compound extremes that have the strongest impacts on ecosystems and society. For example, extreme rainfall in combination with high soil moisture causes floods with severe impacts. Similarly, droughts combined with extreme hot temperatures have particularly devastating impacts on ecosystem functioning. The magnitude of an extreme event can be reflected in its return period. Recently, the concept of copulas has been adapted to estimate multivariate return periods of, e.g., drought extent and duration, peak flow and peak volume, or extreme precipitation events at nearby stations. We use this concept here and estimate bivariate return periods of concurrent hot and dry, and concurrent cold and wet periods of 3 months length on gridded temperature and precipitation data from 1901 onwards. We find a strong increase of concurrent dry and hot periods over the recent decades, in particular in the northern hemisphere. At the same time we detect a decrease in concurrent wet and cold periods. This can be primarily attributed to the strong increase in temperature in many land areas. Averaged over the land surface, the variations of concurrently dry and hot, and cold and wet periods over the 20th century can be related to changes in surface radiation (global dimming and global brightening), which affected both temperature and the hydrological cycle.

  3. 75 FR 7426 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-19

    ... 39 CFR Part 3050 Periodic Reporting AGENCY: Postal Regulatory Commission. ACTION: Advance notice of...-789-6820 or stephen.sharfman@prc.gov . SUPPLEMENTARY INFORMATION: Table of Contents I. Background II... approved for use in periodic reporting.\\1\\ The Postal Service labels its proposal ``Proposal One''...

  4. 76 FR 296 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-04

    ... consider a proposed change in certain analytical methods used in periodic reporting. The proposed change... rulemaking proceeding to consider changes in the analytical methods approved for use in periodic reporting.\\1... Requesting Initiation of a Proceeding to Consider Proposed Changes in Analytic Principles (Proposals...

  5. Time domain period determination techniques

    NASA Technical Reports Server (NTRS)

    Stellingwerf, R. F.

    1980-01-01

    Two simple period determination schemes are discussed. They are well suited to problems involving non-sinusoidal periodic phenomena sampled at a few irregularly spaced points. Statistical properties are discussed. The techniques are applied to the double mode Cepheids BK Cen and TU Cas as test cases.

  6. Time domain period determination techniques

    NASA Astrophysics Data System (ADS)

    Stellingwerf, R. F.

    1980-05-01

    Two simple period determination schemes are discussed. They are well suited to problems involving non-sinusoidal periodic phenomena sampled at a few irregularly spaced points. Statistical properties are discussed. The techniques are applied to the double mode Cepheids BK Cen and TU Cas as test cases.

  7. Interference pattern period measurement at picometer level

    NASA Astrophysics Data System (ADS)

    Xiang, Xiansong; Wei, Chunlong; Jia, Wei; Zhou, Changhe; Li, Minkang; Lu, Yancong

    2016-10-01

    To produce large scale gratings by Scanning Beam Interference Lithography (SBIL), a light spot containing grating pattern is generated by two beams interfering, and a scanning stage is used to drive the substrate moving under the light spot. In order to locate the stage at the proper exposure positions, the period of the Interference pattern must be measured accurately. We developed a set of process to obtain the period value of two interfering beams at picometer level. The process includes data acquisition and data analysis. The data is received from a photodiode and a laser interferometer with sub-nanometer resolution. Data analysis differs from conventional analyzing methods like counting wave peaks or using Fourier transform to get the signal period, after a preprocess of filtering and envelope removing, the mean square error is calculated between the received signal and ideal sinusoid waves to find the best-fit frequency, thus an accuracy period value is acquired, this method has a low sensitivity to amplitude noise and a high resolution of frequency. With 405nm laser beams interfering, a pattern period value around 562nm is acquired by employing this process, fitting diagram of the result shows the accuracy of the period value reaches picometer level, which is much higher than the results of conventional methods.

  8. Isoprenaline and canine cardiac refractory periods.

    PubMed

    Lhoste, F; Giudicelli, J F; Boissier, J R

    1976-09-01

    Atrioventricular refractory periods and their modifications induced by variable doses of sioprenaline have been investigated in dogs. Premature atrial stimuli (St2) were applied at variable intervals following regular stimuli (St1) which ensured atrial pacing. Atrial (AERP), nodoventricular (NERP) and global (GERP) effective refractory periods, as well as the global functional refractory period (GFRP) were determined before, during and after infusion of the drug. In low doses, isoprenaline did not significantly alter these various parameters. This confirms its lack of dromotropic effect on the healthy heart. In contrast, high doses of the drug significantly reduced the refractory periods, probably by simple correction of the negative dromotropic effects resulting from overstimulation. Also when the infusion was stopped, marked but reversible conduction depression was observed. It would appear that this reflects 'exhaustion' of cell metabolism induced by the drug.

  9. Periodic orbits of planets in binary systems

    NASA Astrophysics Data System (ADS)

    Voyatzis, G.

    2017-03-01

    Periodic solutions of the three body problem are very important for understanding its dynamics either in a theoretical framework or in various applications in celestial mechanics. In this paper we discuss the computation and continuation of periodic orbits for planetary systems. The study is restricted to coplanar motion. Starting from known results of two-planet systems around single stars, we perform continuation of solutions with respect to the mass and approach periodic orbits of single planets in two-star systems. Also, families of periodic solutions can be computed for fixed masses of the primaries. When they are linearly stable, we can conclude about the existence of phase space domains of long-term orbital stability.

  10. Long-term results of enriched environment and erythropoietin after hypobaric hypoxia in rats.

    PubMed

    Hralová, M; Angerová, Y; Gueye, T; Bortelová, J; Svestková, O; Zima, T; Lippertová-Grünerová, M

    2013-01-01

    After global cerebral hypoxia, many patients are severely disabled even after intensive neurorehabilitation. Secondary mechanisms of brain injury as a result of biochemical and physiological events occur within a period of hours to months, and provide a window of opportunity for therapeutic intervention. Erythropoietin (EPO) has been shown to be neuroprotective in the brain subjected to a variety of injuries. Fifty-nine 3-month-old male Wistar rats were randomly distributed to experimental groups with respect to the housing (enriched environment - EE, standard housing - SH), to hypoxia exposure, and to EPO treatment. An acute mountain sickness model was used as a hypobaric hypoxia simulating an altitude of 8000 m. One half of the animals received erythropoietin injections, while the others were injected saline. Spatial memory was tested in a Morris water maze (MWM). The escape latency and the path length were measured. Better spatial learning in MWM was only seen in the group that received erythropoietin together with enriched environment. EPO administration itself had no influence on spatial memory. The results were very similar for both latencies and path lengths. These results support the idea that after brain injuries, the recovery can be potentiated by EPO administration combined with neurorehabilitation.

  11. Research Results

    NASA Astrophysics Data System (ADS)

    2011-12-01

    Research on Global Carbon Emission and Sequestration NSFC Funded Project Made Significant Progress in Quantum Dynamics Functional Human Blood Protein Obtained from Rice How Giant Pandas Thrive on a Bamboo Diet New Evidence of Interpersonal Violence from 129,000 Years Ago Found in China Aptamer-Mediated Efficient Capture and Release of T Lymphocytes on Nanostructured Surfaces BGI Study Results on Resequencing 50 Accessions of Rice Cast New Light on Molecular Breeding BGI Reports Study Results on Frequent Mutation of Genes Encoding UMPP Components in Kidney Cancer Research on Habitat Shift Promoting Species Diversification

  12. Tevatron results

    SciTech Connect

    Lefevre, R.; /Barcelona, Autonoma U.

    2005-01-01

    Recent results obtained by the CDF and D0 experiments at the Tevatron Run II are presented. A first part is dedicated to QCD physics where inclusive jet production, dijet azimuthal decorrelations and jet shapes measurements are reported. Electroweak physics is then discussed relating measurements of the W and Z bosons productions, of the forward-backward charge asymmetry in W production, of the W width and of the top quarks mass. The extensive Run II exploration program is finally approached reporting about searches for neutral supersymmetric Higgs bosons in multijet events and for sbottom quark from gluino decays.

  13. The Stability of Periodic Orbits.

    DTIC Science & Technology

    1981-01-21

    I AOB a7 PRIlNCETON UNIV NJ JOSEPH HENRY LABS OF PHYSICS FD 7/S THE STABILITY OF PERIODIC ORBITS. (U) JAN 81 L SNEDOOM N00014-77-C-0711 UNCLASSIFIE-D...NL I - The Stability of Periodic Orbits Leigh Sneddon* Joseph Henry Laboratories of Physics Princeton University Princeton, New Jersey 08544 ABSTRACT...eigenvalue of the Poincare map passes out through the unit circle at -1 : see Appendix 1) 9,10 are observed and are referred to as subharmonic or period

  14. Tailored, iterative, printed dietary feedback is as effective as group education in improving dietary behaviours: results from a randomised control trial in middle-aged adults with cardiovascular risk factors

    PubMed Central

    2011-01-01

    Background Tailored nutrition interventions have been shown to be more effective than non-tailored materials in changing dietary behaviours, particularly fat intake and fruit and vegetable intake. But further research examining efficacy of tailored nutrition education in comparison to other nutrition education methods and across a wider range of dietary behaviours is needed. The Stages to Healthy Eating Patterns Study (STEPs) was an intervention study, in middle-aged adults with cardiovascular risk factors, to examine the effectiveness of printed, tailored, iterative dietary feedback delivered by mail in improving short-term dietary behaviour in the areas of saturated fat, fruit, vegetable and grain and cereal intake. Methods STEPs was a 3-month randomised controlled trial with a pre and post-test design. There were three experimental conditions: 1) tailored, iterative, printed dietary feedback (TF) with three instalments mail-delivered over a 3-month period that were re-tailored to most recent assessment of dietary intake, intention to change and assessment of self-adequacy of dietary intake. Tailoring for dietary intake was performed on data from a validated 63-item combination FFQ designed for the purpose 2) small group nutrition education sessions (GE): consisting of two 90-minute dietitian-led small group nutrition education sessions and 3) and a wait-listed control (C) group who completed the dietary measures and socio-demographic questionnaires at baseline and 3-months later. Dietary outcome measures in the areas of saturated fat intake (g), and the intake of fruit (serves), vegetables (serves), grain and cereals as total and wholegrain (serves) were collected using 7-day estimated dietary records. Descriptive statistics, paired t-tests and general linear models adjusted for baseline dietary intake, age and gender were used to examine the effectiveness of different nutrition interventions. Results The TF group reported a significantly greater increase in

  15. Chaos in Periodic Discrete Systems

    NASA Astrophysics Data System (ADS)

    Shi, Yuming; Zhang, Lijuan; Yu, Panpan; Huang, Qiuling

    This paper focuses on chaos in periodic discrete systems, whose state space may vary with time. Some close relationships between some chaotic dynamical behaviors of a periodic discrete system and its autonomous induced system are given. Based on these relationships, several criteria of chaos are established and some sufficient conditions for no chaos are given for periodic discrete systems. Further, it is shown that a finite-dimensional linear periodic discrete system is not chaotic in the sense of Li-Yorke or Wiggins. In particular, an interesting problem of whether nonchaotic rules may generate a chaotic system is studied, with some examples provided, one of which surprisingly shows that a composition of globally asymptotically stable maps can be chaotic. In addition, some properties of sign pattern matrices of non-negative square matrices are given for convenience of the study.

  16. Autism: a "critical period" disorder?

    PubMed

    LeBlanc, Jocelyn J; Fagiolini, Michela

    2011-01-01

    Cortical circuits in the brain are refined by experience during critical periods early in postnatal life. Critical periods are regulated by the balance of excitatory and inhibitory (E/I) neurotransmission in the brain during development. There is now increasing evidence of E/I imbalance in autism, a complex genetic neurodevelopmental disorder diagnosed by abnormal socialization, impaired communication, and repetitive behaviors or restricted interests. The underlying cause is still largely unknown and there is no fully effective treatment or cure. We propose that alteration of the expression and/or timing of critical period circuit refinement in primary sensory brain areas may significantly contribute to autistic phenotypes, including cognitive and behavioral impairments. Dissection of the cellular and molecular mechanisms governing well-established critical periods represents a powerful tool to identify new potential therapeutic targets to restore normal plasticity and function in affected neuronal circuits.

  17. The Chandlerian Period of minimum excitation

    NASA Astrophysics Data System (ADS)

    Sekiguchi, Naosuke

    Up to the present, the Chandlerian Period has been defined as the mean period of the revolution of the pole around its mean position. However, as the motion of the excitation pole does not contain the Chandlerian component, we can determine the length of the Chandlerian Period under the condition that the motion of the excitation pole attains a minimum after elimination of the Chandlerian component. It is calculated as 416 (mean solar) days. It means the period deduced from the angular velocity of the pole around the instantaneous excitation pole, and is able to match better those deduced from the theory of the internal constitution of the Earth. The calculated results using the recent data of ERP with a high precision show that the Chandlerian Period in this sense seems to have a reality. The main results are shown in the Figure on the next pape. This paper was published in full form in the Journal of the Geodetic Society of Japan, 33 (1987) pp.97-100.

  18. Period Estimation for Sparsely-sampled Quasi-periodic Light Curves Applied to Miras

    NASA Astrophysics Data System (ADS)

    He, Shiyuan; Yuan, Wenlong; Huang, Jianhua Z.; Long, James; Macri, Lucas M.

    2016-12-01

    We develop a nonlinear semi-parametric Gaussian process model to estimate periods of Miras with sparsely sampled light curves. The model uses a sinusoidal basis for the periodic variation and a Gaussian process for the stochastic changes. We use maximum likelihood to estimate the period and the parameters of the Gaussian process, while integrating out the effects of other nuisance parameters in the model with respect to a suitable prior distribution obtained from earlier studies. Since the likelihood is highly multimodal for period, we implement a hybrid method that applies the quasi-Newton algorithm for Gaussian process parameters and search the period/frequency parameter space over a dense grid. A large-scale, high-fidelity simulation is conducted to mimic the sampling quality of Mira light curves obtained by the M33 Synoptic Stellar Survey. The simulated data set is publicly available and can serve as a testbed for future evaluation of different period estimation methods. The semi-parametric model outperforms an existing algorithm on this simulated test data set as measured by period recovery rate and quality of the resulting period-luminosity relations.

  19. Fuel Distribution Estimate via Spin Period to Precession Period Ratio for the Advanced Composition Explorer

    NASA Technical Reports Server (NTRS)

    DeHart, Russell; Smith, Eric; Lakin, John

    2015-01-01

    The spin period to precession period ratio of a non-axisymmetric spin-stabilized spacecraft, the Advanced Composition Explorer (ACE), was used to estimate the remaining mass and distribution of fuel within its propulsion system. This analysis was undertaken once telemetry suggested that two of the four fuel tanks had no propellant remaining, contrary to pre-launch expectations of the propulsion system performance. Numerical integration of possible fuel distributions was used to calculate moments of inertia for the spinning spacecraft. A Fast Fourier Transform (FFT) of output from a dynamics simulation was employed to relate calculated moments of inertia to spin and precession periods. The resulting modeled ratios were compared to the actual spin period to precession period ratio derived from the effect of post-maneuver nutation angle on sun sensor measurements. A Monte Carlo search was performed to tune free parameters using the observed spin period to precession period ratio over the life of the mission. This novel analysis of spin and precession periods indicates that at the time of launch, propellant was distributed unevenly between the two pairs of fuel tanks, with one pair having approximately 20% more propellant than the other pair. Furthermore, it indicates the pair of the tanks with less fuel expelled all of its propellant by 2014 and that approximately 46 kg of propellant remains in the other two tanks, an amount that closely matches the operational fuel accounting estimate. Keywords: Fuel Distribution, Moments of Inertia, Precession, Spin, Nutation

  20. Metamaterial properties of periodic laminates

    NASA Astrophysics Data System (ADS)

    Srivastava, Ankit

    2016-11-01

    In this paper we show that a 1-D phononic crystal (laminate) can exhibit metamaterial wave phenomena which are traditionally associated with 2- and 3-D crystals. Moreover, due to the absence of a length scale in 2 of its dimensions, it can outperform higher dimensional crystals on some measures. This includes allowing only negative refraction over large frequency ranges and serving as a near-omnidirectional high-pass filter up to a large frequency value. First we provide a theoretical discussion on the salient characteristics of the dispersion relation of a laminate and formulate the solution of an interface problem by the application of the normal mode decomposition technique. We present a methodology with which to induce a pure negative refraction in the laminate. As a corollary to our approach of negative refraction, we show how the laminate can be used to steer beams over large angles for small changes in the incident angles (beam steering). Furthermore, we clarify how the transmitted modes in the laminate can be switched on and off by varying the angle of the incident wave by a small amount. Finally, we show that the laminate can be used as a remarkably efficient high-pass frequency filter. An appropriately designed laminate will reflect all plane waves from quasi-static to a large frequency, incident at it from all angles except for a small set of near-normal incidences. This will be true even if the homogeneous medium is impedance matched with the laminate. Due to the similarities between SH waves and electromagnetic (EM) waves it is expected that some or all of these results may also apply to EM waves in a layered periodic dielectric.

  1. Multiscale periodic structure in the Io wake

    NASA Astrophysics Data System (ADS)

    Smith, P. R.; Wright, A. N.

    1989-06-01

    Preliminary results from an eigenmode synthesis of the Alfven waves launched by Io are presented. It is found that several important periodicities emerge. Observations of the decametric emission reveal fine, medium, and large-scale radio structure. These simulations can provide structure on each of these scales, unlike earlier models.

  2. Periodicity of high-order neural functions

    NASA Technical Reports Server (NTRS)

    Kellaway, P.; Borda, R. P.; Frost, J. D.; Carrie, J. R. G.; Coats, A. C.

    1973-01-01

    The results of recent studies on higher order, integrative processes in the central nervous system are reported. Attempts were made to determine whether these processes exhibit any ongoing rhythmicity which might manifest itself in alterations of attention and alertness. Experiments were also designed to determine if a periodicity approximating that of the REM could be detected in various parameters of brain electrical activity.

  3. 12 CFR 1730.3 - Periodic disclosures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... financial statements; (2) The Enterprise files with the Commission all reports, statements, and forms... DEVELOPMENT SAFETY AND SOUNDNESS DISCLOSURE OF FINANCIAL AND OTHER INFORMATION § 1730.3 Periodic disclosures. (a) Each Enterprise shall prepare disclosures relating to its financial condition, results...

  4. 14 CFR 1260.128 - Period of availability of funds.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ....128 Period of availability of funds. Where a funding period is specified, a recipient may charge to the grant only allowable costs resulting from obligations incurred during the funding period and any pre-award costs authorized by NASA. Property Standards...

  5. 14 CFR 1260.128 - Period of availability of funds.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ....128 Period of availability of funds. Where a funding period is specified, a recipient may charge to the grant only allowable costs resulting from obligations incurred during the funding period and any pre-award costs authorized by NASA. Property Standards...

  6. 14 CFR 1260.128 - Period of availability of funds.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ....128 Period of availability of funds. Where a funding period is specified, a recipient may charge to the grant only allowable costs resulting from obligations incurred during the funding period and any pre-award costs authorized by NASA. Property Standards...

  7. 14 CFR 1260.128 - Period of availability of funds.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ....128 Period of availability of funds. Where a funding period is specified, a recipient may charge to the grant only allowable costs resulting from obligations incurred during the funding period and any pre-award costs authorized by NASA. Property Standards...

  8. Frequency selective surfaces with multiple periodic elements

    NASA Astrophysics Data System (ADS)

    Reed, Jeffrey Alan

    A thorough computer design study using the method of Chen1,2,3 was undertaken for band-pass filters constructed from frequency selective surfaces (FSSs). The FSSs, modeled as thin, perfectly conducting surfaces with periodically arranged apertures, were designed to produce a transmission profile with a bandpass characteristic centered at 10.6 μm and to have various specified bandwidths. The effects of aperture shape and dimensions, configuration and periodicity of the aperture array, and presence of a dielectric substrate were examined in- depth. For comparison purposes, a complimentary array of metallic patches was also examined. The successful design (a thin, planar sheet of aluminum perforated with narrow rectangular apertures in a triangular array configuration on a thick zinc selenide substrate) provided a preliminary set of basic design rules for creating bandpass filters from FSSs. Dual resonance transmission profiles were generated by considering a FSS with a group of apertures as the periodic element. Chen's method1,2,3 was modified to work with periodic groups of up to four rectangular or circular shaped apertures (or metallic patches). Combinations of different length narrow slot apertures, combinations of square and narrow slot apertures, and variation of periodicity along alternating rows of narrow slot apertures, all produced a dual resonance transmission profile in the computer model. For the combination of different length narrow apertures, the dual resonance resulted from the natural resonance associated with the two different length narrow apertures, while for the combination of squares and narrow slots, an enhancement of the Wood's anomaly at the diffraction edge created the second resonance peak. Variation of the periodicity along alternating rows produced a dual resonance because each of the 'superimposed arrays' had a different periodicity. The presence of Wood's anomalies in the transmission profile was also examined. Finally, 'proof of

  9. Periodic solar wind density structures

    NASA Astrophysics Data System (ADS)

    Viall, Nicholeen Mary

    2010-01-01

    This dissertation addresses a specific aspect of the Sun-Earth connection: we show that coronal activity creates periodic density structures in the solar wind which convect radially outward and interact with Earth's magnetosphere. First, we analyze 11 years (1995-2005) of in situ solar wind density observations from the Wind spacecraft and find that periodic density structures occur at particular sets of radial length-scales more often than others. This indicates that these density fluctuations, which have radial length-scales of hundreds of megameters, cannot be attributed entirely to turbulence. Next, we analyze their effect on Earth's magnetosphere. Though these structures are not waves in the solar wind rest frame, they appear at discrete frequencies in Earth's reference frame. They compress the magnetosphere as they convect past, driving global magnetospheric oscillations at the same discrete frequencies as the periodic density structures. Last, we investigate source regions and mechanisms of the periodic solar wind density structures. We analyze the alpha particle to proton abundance ratio during events of periodic density structures. In many events, the proton and alpha density fluctuations are anti- correlated, which strongly argues for either temporally or spatially varying coronal source plasma. We examine white light images of the solar wind taken with SECCHI HI1 on the STEREO spacecraft and find periodic density structures as near to the Sun as 15 solar radii. The smallest resolvable periodic structures that we identify are of comparable length to those found at 1 AU, providing further evidence that at least some periodic density structures are generated in the solar corona as the solar wind is formed. Guided by the properties observed during previous studies and the characteristics established through the work presented here, we examine possible candidate mechanisms in the solar corona that can form periodic density structures. We conclude that

  10. Shortest recurrence periods of novae

    SciTech Connect

    Kato, Mariko; Saio, Hideyuki; Hachisu, Izumi; Nomoto, Ken'ichi

    2014-10-01

    Stimulated by the recent discovery of the 1 yr recurrence period nova M31N 2008-12a, we examined the shortest recurrence periods of hydrogen shell flashes on mass-accreting white dwarfs (WDs). We discuss the mechanism that yields a finite minimum recurrence period for a given WD mass. Calculating the unstable flashes for various WD masses and mass accretion rates, we identified a shortest recurrence period of about two months for a non-rotating 1.38 M {sub ☉} WD with a mass accretion rate of 3.6 × 10{sup –7} M {sub ☉} yr{sup –1}. A 1 yr recurrence period is realized for very massive (≳ 1.3 M {sub ☉}) WDs with very high accretion rates (≳ 1.5 × 10{sup –7} M {sub ☉} yr{sup –1}). We revised our stability limit of hydrogen shell burning, which will be useful for binary evolution calculations toward Type Ia supernovae.

  11. [Results of a morphological study of the experimental use of polyglycolide fiber explants in the surgery of retinal detachment].

    PubMed

    Kiseleva, O A; Ziangirova, G G; Iomdina, E N; Aliev, T I

    2005-01-01

    The paper presents the results of experimental use of a polyglycolide material-based filling for temporary episcleral filling in retinal detachment. Thorough comparative morphological and biomechanical studies of 120 experimental eyes in different periods after scleroplasty, by using an inflatable balloon catheter, homoscleral and polyglycolide fillings, have indicated that the polyglycolide filling material is completely lysed by ocular tissues within 60-90 days, which rules out a repeated surgical intervention for removal of temporary filling (for example, an inflatable balloon catheter), by preserving the constancy of the depth of scleral pressing-in. The short existence of a chemically indifferent polyglycolide filling in the ocular tissues excludes its negative effect on the surrounding structures of the eye, minimizes the likelihood of the occurrence of early postoperative complications, but thereby leading to a substantial increase in the biochemical stability of the scleral-and-chorioretinal complex in the early postoperative periods and ensuring increased resistance to dynamic loads, by forming a stable scleral-and-chorioretinal adhesion 3 months after surgery. The findings suggest that the designed polyglycolide explant has advantages and that it is expedient to introduce the new Russian resolving polyglycolide fiber explants into clinical practice (for scleroplastic operations).

  12. Strip and microstrip line periodic heterogeneities

    NASA Astrophysics Data System (ADS)

    Lerer, A. M.; Lerer, B. M.; Ryazanov, V. D.; Sledkov, V. A.

    1985-04-01

    A quasistatic method is described for analyzing periodic heterogeneities in single and coupled strip lines and microstrip lines. An ALGOL program on a BESM-6 computer calculated the running inductance and capacitance, wave impedances and delay coefficients for single and coupled strip lines and microstrip lines with periodic heterogeneities of arbitrary form. The analyzed quantities are investigated as a function of distance (from side shield to the strip), number of terms in the series and number of approximated functions. The method demonstrates good convergence and requires little machine time and results were verified experimentally.

  13. Onsager coefficients for systems with periodic potentials

    NASA Astrophysics Data System (ADS)

    Rosas, Alexandre; Van den Broeck, Christian; Lindenberg, Katja

    2016-11-01

    We carry out the thermodynamic analysis of a Markovian stochastic engine, driven by a spatially and temporally periodic modulation in a d -dimensional space. We derive the analytic expressions for the Onsager coefficients characterizing the linear response regime for the isothermal transfer of one type of work (a driver) to another (a load), mediated by a stochastic time-periodic machine. As an illustration, we obtain the explicit results for a Markovian kangaroo process coupling two orthogonal directions and find extremely good agreement with numerical simulations. In addition, we obtain and discuss expressions for the entropy production, power, and efficiency for the kangaroo process.

  14. Ground states for nonuniform periodic Ising chains.

    PubMed

    Martínez-Garcilazo, J P; Ramírez, C

    2015-04-01

    We generalize Morita's works [J. Phys. A 7, 289 (1974); J. Phys. A 7, 1613 (1974)] on ground states of Ising chains, for chains with a periodic structure and different spins, to any interaction order. The main assumption is translational invariance. The length of the irreducible blocks is a multiple of the period of the chain. If there is parity invariance, it restricts the length in general only in the diatomic case. There are degenerated states and under certain circumstances there could be nonregular ground states. We illustrate the results and give the ground state diagrams in several cases.

  15. The period functionsʼ higher order derivatives

    NASA Astrophysics Data System (ADS)

    Sabatini, M.

    We prove a formula for the n-th derivative of the period function T in a period annulus of a planar differential system. For n=1, we obtain Freire, Gasull and Guillamon formula for the period's first derivative (Chicone and Dumortier, 1993) [17]. We apply such a result to Hamiltonian systems with separable variables and other systems. We give some sufficient conditions for the period function of conservative second order ODE's to be convex.

  16. Geologic periodicities and the Galaxy

    NASA Technical Reports Server (NTRS)

    Rampino, Michael R.; Stothers, Richard B.

    1986-01-01

    New geologic and astronomical developments are reviewed that have recently led to the proposal of various Galactic theories to explain the temporal pattern of impact craters on earth. Linear and harmonic time series analyses have revealed that two dominant periodicities about equal to 33 + or - 3 Myr and 260 + or - 25 Myr underlie the geologic record of terrestrial impact cratering and global tectonic phenomena. It is argued that purely terrestrial mechanisms cannot account for the cratering cycles as being preservational artifacts; cratering rather appears to influence tectonism, possibly through perturbations of mantle convection. Galactic models proposed to explain the two long-term periodicities are reviewed critically. The most likely explanation for the 33 Myr cycle involves the comparatively stable half period of vertical oscillation of the solar system about the Galactic plane. The 260 Myr cycle may be related to rare encounters with Galactic spiral arms during the revolution of the solar system around the Galactic center.

  17. Discovering Periodic Patterns in Historical News.

    PubMed

    Dzogang, Fabon; Lansdall-Welfare, Thomas; Cristianini, Nello

    2016-01-01

    We address the problem of observing periodic changes in the behaviour of a large population, by analysing the daily contents of newspapers published in the United States and United Kingdom from 1836 to 1922. This is done by analysing the daily time series of the relative frequency of the 25K most frequent words for each country, resulting in the study of 50K time series for 31,755 days. Behaviours that are found to be strongly periodic include seasonal activities, such as hunting and harvesting. A strong connection with natural cycles is found, with a pronounced presence of fruits, vegetables, flowers and game. Periodicities dictated by religious or civil calendars are also detected and show a different wave-form than those provoked by weather. States that can be revealed include the presence of infectious disease, with clear annual peaks for fever, pneumonia and diarrhoea. Overall, 2% of the words are found to be strongly periodic, and the period most frequently found is 365 days. Comparisons between UK and US, and between modern and historical news, reveal how the fundamental cycles of life are shaped by the seasons, but also how this effect has been reduced in modern times.

  18. Discovering Periodic Patterns in Historical News

    PubMed Central

    Dzogang, Fabon; Lansdall-Welfare, Thomas; Cristianini, Nello

    2016-01-01

    We address the problem of observing periodic changes in the behaviour of a large population, by analysing the daily contents of newspapers published in the United States and United Kingdom from 1836 to 1922. This is done by analysing the daily time series of the relative frequency of the 25K most frequent words for each country, resulting in the study of 50K time series for 31,755 days. Behaviours that are found to be strongly periodic include seasonal activities, such as hunting and harvesting. A strong connection with natural cycles is found, with a pronounced presence of fruits, vegetables, flowers and game. Periodicities dictated by religious or civil calendars are also detected and show a different wave-form than those provoked by weather. States that can be revealed include the presence of infectious disease, with clear annual peaks for fever, pneumonia and diarrhoea. Overall, 2% of the words are found to be strongly periodic, and the period most frequently found is 365 days. Comparisons between UK and US, and between modern and historical news, reveal how the fundamental cycles of life are shaped by the seasons, but also how this effect has been reduced in modern times. PMID:27824911

  19. Boundary element solution for periodic acoustic problems

    NASA Astrophysics Data System (ADS)

    Karimi, M.; Croaker, P.; Kessissoglou, N.

    2016-01-01

    This work shows when using the boundary element method to solve 3D acoustic scattering problems from periodic structures, the coefficient matrix can be represented as a block Toeplitz matrix. By exploiting the Toeplitz structure, the computational time and storage requirements to construct the coefficient matrix are significantly reduced. To solve the linear system of equations, the original matrix is embedded into a larger and more structured matrix called the block circulant matrix. Discrete Fourier transform is then employed in an iterative algorithm to solve the block Toeplitz system. To demonstrate the effectiveness of the formulation for periodic acoustic problems, two exterior acoustic case studies are considered. The first case study examines a continuous structure to predict the noise generated by a sharp-edged flat plate under quadrupole excitation. Directivity plots obtained using the periodic boundary element method technique are compared with numerical results obtained using a conventional boundary element model. The second case study examines a discrete periodic structure to predict the acoustic performance of a sonic crystal noise barrier. Results for the barrier insertion loss are compared with both finite element results and available data in the literature.

  20. Periodicity in marine extinction events

    NASA Technical Reports Server (NTRS)

    Sepkoski, J. John, Jr.; Raup, David M.

    1986-01-01

    The periodicity of extinction events is examined in detail. In particular, the temporal distribution of specific, identifiable extinction events is analyzed. The nature and limitations of the data base on the global fossil record is discussed in order to establish limits of resolution in statistical analyses. Peaks in extinction intensity which appear to differ significantly from background levels are considered, and new analyses of the temporal distribution of these peaks are presented. Finally, some possible causes of periodicity and of interdependence among extinction events over the last quarter billion years of earth history are examined.

  1. Sigmoid Volvulus Complicating Postpartum Period

    PubMed Central

    Blake, Erin; Gonzalez, Eduardo; Pieracci, Frederic

    2017-01-01

    Background. Sigmoid volvulus is a rare complication of pregnancy and the puerperium. Case. A 19-year-old patient, gravida 1 para 0 at 41 0/7 weeks of gestation, admitted for late-term induction of labor underwent an uncomplicated primary low transverse cesarean delivery for arrest of descent. Her postoperative period was complicated by sudden onset of abdominal pain and the ultimate diagnosis of sigmoid volvulus. Conclusion. Prompt surgical evaluation of an acute abdomen in the postpartum period is essential; delayed diagnosis and treatment can lead to significant maternal morbidity and mortality. PMID:28251004

  2. Optimizing observing sequence design for periodic and non-periodic phenomena : a Bayesian approach

    NASA Technical Reports Server (NTRS)

    Johnston, Mark D.; Knight, Russell

    2005-01-01

    In this paper we report on our progress on addressing these issues. We have developed an approximate expression for the uniformity of phase coverage that can be used when scheduling to assess candidate sample times. We describe the results obtained using this estimator, and compare them with detailed simulations. We describe our progress and plans for integrating optimizing criteria for both periodic and non-periodic observations into a single observation sequence.

  3. The Association between Serum Leptin and Post Stroke Depression: Results from a Cohort Study

    PubMed Central

    Zhang, Hua-jing; Zhao, Wen-li

    2014-01-01

    Background Depression is a frequent mood disorder that affects around a third of stroke patients and has been associated with poorer outcomes. Our aim was to determine whether there was a relationship between inflammatory markers (leptin) and post-stroke depression (PSD). Methods One hundred and ninety-one ischemic stroke patients admitted to the hospital within the first 24 hours after stroke onset were consecutively recruited and followed up for 3 months. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of leptin at admission. Based on the symptoms, diagnoses of depression were made in accordance with DSM-IV criteria for post-stroke depression at 3 month. Results Forty-four patients (23.0%) were diagnosed as having major depression at 3 month. Patients with depression showed higher serum leptin levels at 3 month after stroke (32.2 [IQR, 20.8–57.7] v. 9.9 [IQR, 4.6–13.1]ng/ml, respectively; P = 0.000). Serum levels of leptin ≥20 ng/ml were independently associated with PSD [odds ratio (OR) 20.23, 95% confidence interval (CI) 9.11–51.26, P =  0.000], after adjusting for possible confounders. Conclusions Serum leptin levels elevated at admission were found to be associated with PSD and may provide a new proposal for the treatment of PSD. PMID:25061971

  4. Treatment of replacement resorption by intentional replantation, resection of the ankylosed sites, and Emdogain--results of a 6-year survey.

    PubMed

    Filippi, Andreas; Pohl, Yango; von Arx, Thomas

    2006-12-01

    The present clinical study investigated the outcome of intentional replantation using resection of the ankylosed sites of the root, extraoral endodontic treatment using titanium posts and Emdogain for periodontal healing following trauma-related ankylosis. During an evaluation period of 6 years, 16 ankylosed teeth affected by replacement resorption were treated as described. Evaluation parameters before treatment and during the follow-up period included Periotest scores, percussion sound and periapical radiographs. All findings were compared to those of the adjacent teeth. In a second accident, one tooth was lost after 7 months and was excluded as a dropout. Ankylosis did not recur in seven replanted teeth, which were observed for an average of 52.3 months (range: 24-68 months). Ankylosis recurred in eight teeth after an average period of 12 months (range: 4-26 months). An infraocclusion, normal or only slightly reduced Periotest scores and normal percussion sound were preoperatively found in six of seven successfully replanted teeth, which corresponded to a relatively small area of ankylosis. The majority of the teeth showing recurrent ankylosis preoperatively presented with normal position, negative Periotest scores and a high percussion sound which corresponded to an extended area of ankylosis. Statistically significant relationship between preoperative findings and the treatment outcome (P = 0.031) have become apparent. The results indicate that the treatment of minor areas of ankylosis by intentional replantation, resection of the ankylosed sites and Emdogain appeared to prevent or delay the recurrence of ankylosis in 7 of 15 teeth.

  5. Gene expression profiling in the pituitary gland of laying period and ceased period huoyan geese.

    PubMed

    Luan, Xinhong; Cao, Zhongzan; Xu, Wen; Gao, Ming; Wang, Laiyou; Zhang, Shuwei

    2013-07-01

    Huoyan goose is a Chinese local breed famous for its higher laying performance, but the problems of variety degeneration have emerged recently, especially a decrease in the number of eggs laid. In order to better understand the molecular mechanism that underlies egg laying in Huoyan geese, gene profiles in the pituitary gland of Huoyan geese taken during the laying period and ceased period were investigated using the suppression subtractive hybridization (SSH) method. Total RNA was extracted from pituitary glands of ceased period and laying period geese. The cDNA in the pituitary glands of ceased geese was subtracted from the cDNA in the pituitary glands of laying geese (forward subtraction); the reverse subtraction was also performed. After sequencing and annotation, a total of 30 and 24 up and down-regulated genes were obtained from the forward and reverse SSH libraries, respectively. These genes mostly related to biosynthetic process, cellular nitrogen compound metabolic process, transport, cell differentiation, cellular protein modification process, signal transduction, small molecule metabolic process. Furthermore, eleven genes were selected for further analyses by quantitative real-time PCR (qRT-PCR). The qRT-PCR results for the most part were consistent with the SSH results. Among these genes, Synaptotagmin-1 (SYT1) and Stathmin-2 (STMN2) were substantially over-expressed in laying period compared to ceased period. These results could serve as an important reference for elucidating the molecular mechanism of higher laying performance in Huoyan geese.

  6. 76 FR 80312 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... of the Business Reply Mail cost model in periodic reporting of service performance measurement... initiate a rulemaking proceeding to address the current methodology used to develop the avoided cost.... SUMMARY: The Commission is establishing a docket to consider new measurement of Flats Sequencing...

  7. A Special Section. College Periodicals.

    ERIC Educational Resources Information Center

    Currents, 1988

    1988-01-01

    Special section includes "True to Format," an editor's guide to periodicals (Robin Goldman); "The Move to Magazine," focusing on format (Patricia Ann LaSalle); "The Fast-paced Alternative," about timely tabloids (Janis D. Gleason, Lynn Donham); and also about tabloids, "Why Don't We Have a Magazine?" (Marsha…

  8. 76 FR 20906 - Periodic Reporting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-14

    ... a proposed change in certain analytical methods used in periodic reporting. This action responds to... an informal rulemaking proceeding to consider changes in the analytical methods approved for use in... Proceeding to Consider Proposed Changes in Analytic Principles (Proposal One), April 6, 2011...

  9. Quantifying periodicity in omics data

    PubMed Central

    Amariei, Cornelia; Tomita, Masaru; Murray, Douglas B.

    2014-01-01

    Oscillations play a significant role in biological systems, with many examples in the fast, ultradian, circadian, circalunar, and yearly time domains. However, determining periodicity in such data can be problematic. There are a number of computational methods to identify the periodic components in large datasets, such as signal-to-noise based Fourier decomposition, Fisher's g-test and autocorrelation. However, the available methods assume a sinusoidal model and do not attempt to quantify the waveform shape and the presence of multiple periodicities, which provide vital clues in determining the underlying dynamics. Here, we developed a Fourier based measure that generates a de-noised waveform from multiple significant frequencies. This waveform is then correlated with the raw data from the respiratory oscillation found in yeast, to provide oscillation statistics including waveform metrics and multi-periods. The method is compared and contrasted to commonly used statistics. Moreover, we show the utility of the program in the analysis of noisy datasets and other high-throughput analyses, such as metabolomics and flow cytometry, respectively. PMID:25364747

  10. Shell Games: Uncovering Periodic Properties.

    ERIC Educational Resources Information Center

    Lamb, William G.

    1983-01-01

    Describes activities (demonstrations/experiments) used to introduce history of periodic properties--without electrons, orbitals, filling shells, or any conception of atoms beyond Dalton's model. Activities supplement first chapter in a currently available chemistry text. Indicates potential danger of experiments if proper safety precautions are…

  11. The Period of Salutary Neglect.

    ERIC Educational Resources Information Center

    Hyland, John T.; And Others

    1987-01-01

    Presents a lesson designed to teach students about the period of Salutary Neglect (100 years before the French and Indian Wars) and its effects on later historical events. Provides an advance organizer which puts students in a situation of salutary neglect and includes student and teacher resources on the Stamp Act, the Townshend Acts, and the…

  12. Hyperkalemic periodic paralysis associated with multiple sleep onset REM periods.

    PubMed

    Iranzo, A; Santamaria, J

    1999-12-15

    A 24-year-old man with sporadic hyperkalemic periodic paralysis (HPP) presented with moderate excessive daytime sleepiness and transitory episodes of weakness which occurred during and after sleep. Multiple sleep latency test (MSLT) demonstrated the presence of five sleep onset REM periods (SOREMPs) and a sleep latency of five minutes. Treatment with a diuretic which decreases serum potassium resolved all the clinical symtomps and a new MSLT showed the absence of SOREMPs and a sleep latency of 13.5 minutes. To our knowledge, the patient herein reported is the first case that associates sleep abnormalities and multiple SOREMPs with HPP. Furthermore, the present case suggests that SOREMPs may be explained by an increased extracellular potassium conductance related to HPP.

  13. 12 CFR 390.285 - Audit period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 5 2012-01-01 2012-01-01 false Audit period. 390.285 Section 390.285 Banks and... Associations § 390.285 Audit period. The audit period of a State savings association means the twelve month period (or other period in the case of a change in audit period) covered by the annual audit conducted...

  14. 12 CFR 161.6 - Audit period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Audit period. 161.6 Section 161.6 Banks and... SAVINGS ASSOCIATIONS § 161.6 Audit period. The audit period of a savings association means the twelve month period (or other period in the case of a change in audit period) covered by the annual...

  15. 12 CFR 561.6 - Audit period.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 6 2012-01-01 2012-01-01 false Audit period. 561.6 Section 561.6 Banks and... SAVINGS ASSOCIATIONS § 561.6 Audit period. The audit period of a savings association means the twelve month period (or other period in the case of a change in audit period) covered by the annual...

  16. 12 CFR 390.285 - Audit period.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 5 2013-01-01 2013-01-01 false Audit period. 390.285 Section 390.285 Banks and... Associations § 390.285 Audit period. The audit period of a State savings association means the twelve month period (or other period in the case of a change in audit period) covered by the annual audit conducted...

  17. 7 CFR 1160.113 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 9 2010-01-01 2009-01-01 true Fiscal period. 1160.113 Section 1160.113 Agriculture... Definitions § 1160.113 Fiscal period. Fiscal period means the initial period of up to 30 months that this subpart is effective. Thereafter, the fiscal period shall be such annual period as the Board may...

  18. Quantum gates by periodic driving

    PubMed Central

    Shi, Z. C.; Wang, W.; Yi, X. X.

    2016-01-01

    Topological quantum computation has been extensively studied in the past decades due to its robustness against decoherence. One way to realize the topological quantum computation is by adiabatic evolutions—it requires relatively long time to complete a gate, so the speed of quantum computation slows down. In this work, we present a method to realize single qubit quantum gates by periodic driving. Compared to adiabatic evolution, the single qubit gates can be realized at a fixed time much shorter than that by adiabatic evolution. The driving fields can be sinusoidal or square-well field. With the sinusoidal driving field, we derive an expression for the total operation time in the high-frequency limit, and an exact analytical expression for the evolution operator without any approximations is given for the square well driving. This study suggests that the period driving could provide us with a new direction in regulations of the operation time in topological quantum computation. PMID:26911900

  19. Advanced downhole periodic seismic generator

    DOEpatents

    Hardee, Harry C.; Hills, Richard G.; Striker, Richard P.

    1991-07-16

    An advanced downhole periodic seismic generator system for transmitting variable frequency, predominantly shear-wave vibration into earth strata surrounding a borehole. The system comprises a unitary housing operably connected to a well head by support and electrical cabling and contains clamping apparatus for selectively clamping the housing to the walls of the borehole. The system further comprises a variable speed pneumatic oscillator and a self-contained pneumatic reservoir for producing a frequency-swept seismic output over a discrete frequency range.

  20. Down hole periodic seismic generator

    DOEpatents

    Hardee, Harry C.; Hills, Richard G.; Striker, Richard P.

    1989-01-01

    A down hole periodic seismic generator system for transmitting variable frequency, predominantly shear-wave vibration into earth strata surrounding a borehole. The system comprises a unitary housing operably connected to a well head by support and electrical cabling and contains clamping apparatus for selectively clamping the housing to the walls of the borehole. The system further comprises a variable speed pneumatic oscillator and a self-contained pneumatic reservoir for producing a frequency-swept seismic output over a discrete frequency range.

  1. Database of Periodic DNA Regions in Major Genomes.

    PubMed

    Frenkel, Felix E; Korotkova, Maria A; Korotkov, Eugene V

    2017-01-01

    Summary. We analyzed several prokaryotic and eukaryotic genomes looking for the periodicity sequences availability and employing a new mathematical method. The method envisaged using the random position weight matrices and dynamic programming. Insertions and deletions were allowed inside periodicities, thus adding a novelty to the results we obtained. A periodicity length, one of the key periodicity features, varied from 2 to 50 nt. Totally over 60,000 periodicity sequences were found in 15 genomes including some chromosomes of the H. sapiens (partial), C. elegans, D. melanogaster, and A. thaliana genomes.

  2. Database of Periodic DNA Regions in Major Genomes

    PubMed Central

    2017-01-01

    Summary. We analyzed several prokaryotic and eukaryotic genomes looking for the periodicity sequences availability and employing a new mathematical method. The method envisaged using the random position weight matrices and dynamic programming. Insertions and deletions were allowed inside periodicities, thus adding a novelty to the results we obtained. A periodicity length, one of the key periodicity features, varied from 2 to 50 nt. Totally over 60,000 periodicity sequences were found in 15 genomes including some chromosomes of the H. sapiens (partial), C. elegans, D. melanogaster, and A. thaliana genomes. PMID:28182099

  3. Periodic fevers and autoinflammatory syndromes in childhood.

    PubMed

    Ostring, Genevieve T; Singh-Grewal, Davinder

    2016-09-01

    Recurrent fever is a common presentation in paediatric practice and can be caused by a wide variety of diseases including autoinflammatory conditions. The innate immune system plays an essential role in the 'first line' response to infection through mediation of inflammatory responses. Inflammasomes are part of the regulatory process for this system and result in the production of the powerful pro-inflammatory cytokine interleukin-1B. Dysregulation of inflammasomes, and Interleukin 1 production, contributes to the pathogenesis of autoinflammatory diseases. This review focuses on described periodic fever syndromes (PFS) which are now collectively referred to as autoinflammatory syndromes. Conditions discussed include periodic fever aphthous stomatitis pharyngitis and cervical adenopathy, familial Mediterranean fever, tumour necrosis factor receptor-associated periodic syndromes, hyperimmunoglobulinaemia D and the cryopyrin-associated periodic syndromes. Presenting features, complications, diagnostic and treatment approaches for these conditions are discussed. Nonetheless, as most of these conditions are rare and may have significant long-term complications, it is recommended that they be managed in consultations with a physician experienced in managing PFS.

  4. Hair Drug Testing Results and Self-reported Drug Use among Primary Care Patients with Moderate-risk Illicit Drug Use

    PubMed Central

    Gryczynski, Jan; Schwartz, Robert P.; Mitchell, Shannon Gwin; O’Grady, Kevin E.; Ondersma, Steven J.

    2014-01-01

    Background This study sought to examine the utility of hair testing as a research measure of drug use among individuals with moderate-risk drug use based on the internationally-validated Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST). Methods This study is a secondary analysis using baseline data from a randomized trial of brief intervention for drug misuse, in which 360 adults with moderate-risk drug use were recruited from two community clinics in New Mexico, USA. The current study compared self-reported drug use on the ASSIST with laboratory analysis of hair samples using a standard commercially-available 5-panel test with assay screening and gas chromatography/mass spectrometry (GC/MS) confirmation. Both self-report and hair testing covered a 3 month period. Results Overall concordance between hair testing and self-report was 57.5% (marijuana), 86.5% (cocaine), 85.8% (amphetamines), and 74.3% (opioids). Specificity of hair testing at standard laboratory cut-offs exceeded 90% for all drugs, but sensitivity of hair testing relative to self-report was low, identifying only 52.3% (127/243) of self-disclosed marijuana users, 65.2% (30/46) of cocaine users, 24.2% (8/33) of amphetamine users, and 2.9% (2/68) of opioid users. Among participants who disclosed using marijuana or cocaine in the past 3 months, participants with a negative hair test tended to report lower-frequency use of those drugs (p< .001 for marijuana and cocaine). Conclusions Hair testing can be useful in studies with moderate-risk drug users, but the potential for under-identification of low-frequency use suggests that researchers should consider employing low detection cut-offs and using hair testing in conjunction with self-report. PMID:24932945

  5. Periods of High Intensity Solar Proton Flux

    NASA Technical Reports Server (NTRS)

    Xapsos, Michael A.; Stauffer, Craig A.; Jordan, Thomas M.; Adams, James H.; Dietrich, William F.

    2012-01-01

    Analysis is presented for times during a space mission that specified solar proton flux levels are exceeded. This includes both total time and continuous time periods during missions. Results for the solar maximum and solar minimum phases of the solar cycle are presented and compared for a broad range of proton energies and shielding levels. This type of approach is more amenable to reliability analysis for spacecraft systems and instrumentation than standard statistical models.

  6. Chromatic effects in long periodic transport channels

    SciTech Connect

    Litvinenko V. N.; Hao, Y.; Jing, Y.

    2015-05-03

    Long periodic transport channels are frequently used in accelerator complexes and suggested for using in high-energy ERLs for electron-hadron colliders. Without proper chromaticity compensation, such transport channels exhibit high sensitivity to the random orbit errors causing significant emittance growth. Such emittance growth can come from both the correlated and the uncorrelated energy spread. In this paper we present results of our theoretical and numerical studies of such effects and develop a criteria for acceptable chromaticity in such channels.

  7. Periodic thermomagnetic structures in solar plasma

    SciTech Connect

    Kovalev, V. A.; Laptukhov, A. I.

    2009-04-15

    Stationary solutions in the form of small-scale periodic cells in a plane perpendicular to the magnetic field are obtained in the framework of two-fluid magnetohydrodynamics. The solutions are established as a result of the development of thermal instability and represent a superposition of standing temperature waves. In solving the problem, an expression is used for a generalized heat source (including heating and radiative cooling) that forms a temperature transition region between the chromosphere and corona.

  8. 7 CFR 1205.29 - Reporting results.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Procedures for Conduct of Sign-up Period Procedures § 1205.29 Reporting results. (a) Each county FSA office... that requested a continuance referendum, through the sign-up period, to the Deputy...

  9. 7 CFR 1205.29 - Reporting results.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Procedures for Conduct of Sign-up Period Procedures § 1205.29 Reporting results. (a) Each county FSA office... that requested a continuance referendum, through the sign-up period, to the Deputy...

  10. 7 CFR 1205.29 - Reporting results.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Procedures for Conduct of Sign-up Period Procedures § 1205.29 Reporting results. (a) Each county FSA office... that requested a continuance referendum, through the sign-up period, to the Deputy...

  11. 7 CFR 1205.29 - Reporting results.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Procedures for Conduct of Sign-up Period Procedures § 1205.29 Reporting results. (a) Each county FSA office... that requested a continuance referendum, through the sign-up period, to the Deputy...

  12. 7 CFR 1205.29 - Reporting results.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Procedures for Conduct of Sign-up Period Procedures § 1205.29 Reporting results. (a) Each county FSA office... that requested a continuance referendum, through the sign-up period, to the Deputy...

  13. Epidemiological characteristics and predictors of late presentation of HIV infection in Barcelona (Spain) during the period 2001-2009

    PubMed Central

    2011-01-01

    Background Early diagnosis of HIV infection can prevent morbidity and mortality as well as reduce HIV transmission. The aim of the present study was to assess prevalence, describe trends and identify factors associated with late presentation of HIV infection in Barcelona (Spain) during the period 2001-09. Methods Demographic and epidemiological characteristics of cases reported to the Barcelona HIV surveillance system were analysed. Late presentation was defined for individuals with a CD4 count below 350 cells/ml upon HIV diagnosis or diagnosis of AIDS within 3 months of HIV diagnosis. Multivariate logistic regression were used to identify predictors of late presentation. Results Of the 2,938 newly diagnosed HIV-infected individuals, 2,507 (85,3%) had either a CD4 cell count or an AIDS diagnosis available. A total of 1,139 (55.6%) of the 2,507 studied cases over these nine years were late presenters varying from 48% among men who have sex with men to 70% among heterosexual men. The proportion of late presentation was 62.7% in 2001-2003, 51.9% in 2004-2005, 52.6% in 2006-2007 and 52.1% in 2008-2009. A decrease over time only was observed between 2001-2003 and 2004-2005 (p = 0.001) but remained constant thereafter (p = 0.9). Independent risk factors for late presentation were older age at diagnosis (p < 0.0001), use of injected drugs by men (p < 0.0001), being a heterosexual men (p < 0.0001), and being born in South America (p < 0.0001) or sub-Saharan Africa (p = 0.002). Conclusion Late presentation of HIV is still too frequent in all transmission groups in spite of a strong commitment with HIV prevention in our city. It is necessary to develop interventions that increase HIV testing and facilitate earlier entry into HIV care. PMID:21729332

  14. Haemocytic periodicity and periodic disorders: Periodic neutropenia, thrombocytopenia, lymphocytosis and anaemia

    PubMed Central

    Reimann, Hobart A.

    1971-01-01

    Evidence has accumulated of rhythmic numerical oscillation of each of the blood cells either independently or in combinations. The cyclic changes originate in the marrow of some normal persons and animals without causing illness, and can be induced experimentally. In more than 100 reported instances, periodic oscillations of various cells were accompanied by respective episodes of the disorders named in the title. The disorders may be transitory but usually recur throughout life and occasionally are fatal. All resist therapy. Features in common suggest an interrelationship of the haemal disorders and other disparate heritable periodic diseases. Theoretically, the rhythms are regulated by ubiquitous, inherent, intracellular bioclocks controlled hypothalamically or neurohumorally in relation to a feedback mechanism. Reactions to long cycles are of greater clinical importance than disturbances arising from the circadian rhythm. PMID:4397784

  15. 43 CFR 10010.45 - Time periods.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false Time periods. 10010.45 Section 10010.45... Environmental Impact Statements § 10010.45 Time periods. (a) The minimum review period for a draft EIS will be... proposed reductions in time periods or any extensions of time periods proposed by those agencies....

  16. 44 CFR 206.112 - Registration period.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 44 Emergency Management and Assistance 1 2011-10-01 2011-10-01 false Registration period. 206.112... Households § 206.112 Registration period. (a) Initial period. The standard FEMA registration period is 60...) Extension of the registration period. The regional administrator or his/her designee may extend...

  17. 44 CFR 206.112 - Registration period.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 44 Emergency Management and Assistance 1 2014-10-01 2014-10-01 false Registration period. 206.112... Households § 206.112 Registration period. (a) Initial period. The standard FEMA registration period is 60...) Extension of the registration period. The regional administrator or his/her designee may extend...

  18. 44 CFR 206.112 - Registration period.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 44 Emergency Management and Assistance 1 2013-10-01 2013-10-01 false Registration period. 206.112... Households § 206.112 Registration period. (a) Initial period. The standard FEMA registration period is 60...) Extension of the registration period. The regional administrator or his/her designee may extend...

  19. 44 CFR 206.112 - Registration period.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 44 Emergency Management and Assistance 1 2012-10-01 2011-10-01 true Registration period. 206.112... Households § 206.112 Registration period. (a) Initial period. The standard FEMA registration period is 60...) Extension of the registration period. The regional administrator or his/her designee may extend...

  20. 44 CFR 206.112 - Registration period.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Registration period. 206.112... Households § 206.112 Registration period. (a) Initial period. The standard FEMA registration period is 60...) Extension of the registration period. The regional administrator or his/her designee may extend...

  1. 43 CFR 10010.45 - Time periods.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 43 Public Lands: Interior 2 2012-10-01 2012-10-01 false Time periods. 10010.45 Section 10010.45... Environmental Impact Statements § 10010.45 Time periods. (a) The minimum review period for a draft EIS will be... proposed reductions in time periods or any extensions of time periods proposed by those agencies....

  2. 43 CFR 10010.45 - Time periods.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 43 Public Lands: Interior 2 2014-10-01 2014-10-01 false Time periods. 10010.45 Section 10010.45... Environmental Impact Statements § 10010.45 Time periods. (a) The minimum review period for a draft EIS will be... proposed reductions in time periods or any extensions of time periods proposed by those agencies....

  3. 43 CFR 10010.45 - Time periods.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false Time periods. 10010.45 Section 10010.45... Environmental Impact Statements § 10010.45 Time periods. (a) The minimum review period for a draft EIS will be... proposed reductions in time periods or any extensions of time periods proposed by those agencies....

  4. Long-term result and patient reported outcome of wrist splint treatment for carpal tunnel syndrome.

    PubMed

    Povlsen, Bo; Bashir, Muhammad; Wong, Fabian

    2014-06-01

    Carpal tunnel syndrome (CTS) is the commonest peripheral neuropathy presenting to specialist hand and wrist clinics. This study investigated the long-term outcome of carpal tunnel syndrome treated with isolated night wrist splint and the factors determining the likelihood of success of this intervention. Seventy-five patients referred to a specialist hand clinic with CTS were given night wrist splint treatment for 3 months as per a previous study protocol. Fifty-two patients from this cohort did not wish to have surgery after wrist splint treatment and were followed for a further 33-month period. Baseline pain and numbness levels were recorded on a Visual Analogue Scale (VAS) using a questionnaire upon first presentation. A further questionnaire at 36 months reassessed pain and numbness levels, patients' satisfaction with the treatment, and whether they had subsequent surgical decompression. Of the patients who completed the follow-up questionnaire 33 months after their period of conservative management, 43% were successfully treated with splint treatment alone. There was no difference in the VAS for pain or numbness at the baseline and at 36 months between successful and failed treatment groups. Patients successfully treated with wrist splinting alone reported a higher level of satisfaction with their treatment compared to patients who failed wrist splint treatment or had surgical decompression. The results reinforce the previous recommendation on wrist splinting as a first-line treatment in the Primary Care setting. Referral to specialist hand and wrist clinics should be reserved for patients with symptoms refractory to this initial measure.

  5. Long-Period Solar Variability

    SciTech Connect

    GAUTHIER,JOHN H.

    2000-07-20

    Terrestrial climate records and historical observations of the Sun suggest that the Sun undergoes aperiodic oscillations in radiative output and size over time periods of centuries and millenia. Such behavior can be explained by the solar convective zone acting as a nonlinear oscillator, forced at the sunspot-cycle frequency by variations in heliomagnetic field strength. A forced variant of the Lorenz equations can generate a time series with the same characteristics as the solar and climate records. The timescales and magnitudes of oscillations that could be caused by this mechanism are consistent with what is known about the Sun and terrestrial climate.

  6. Periodic permanent magnet focused klystron

    DOEpatents

    Ferguson, Patrick; Read, Michael; Ives, R Lawrence

    2015-04-21

    A periodic permanent magnet (PPM) klystron has beam transport structures and RF cavity structures, each of which has permanent magnets placed substantially equidistant from a beam tunnel formed about the central axis, and which are also outside the extent of a cooling chamber. The RF cavity sections also have permanent magnets which are placed substantially equidistant from the beam tunnel, but which include an RF cavity coupling to the beam tunnel for enhancement of RF carried by an electron beam in the beam tunnel.

  7. Chronic speciation in periodical cicadas.

    PubMed

    Ritchie, M G.

    2001-02-01

    Allochronic speciation and reproductive character displacement are two intuitively attractive models of speciation. The first proposes that changes in the timing of life cycles produce new species, whereas the second suggests that speciation is due to the exaggeration of sexual isolation in sympatric populations. Clear examples of either process in nature remain elusive, despite some extensive searches. Two recent studies of mtDNA markers and behaviour of periodical cicadas in North America have identified a new species of cicada that seems to provide good evidence for the involvement of both processes in its origin.

  8. Post-equinox periodicities in Saturn's energetic electrons

    NASA Astrophysics Data System (ADS)

    Carbary, J. F.; Mitchell, D. G.; Krimigis, S. M.; Krupp, N.

    2011-12-01

    Since Saturn's vernal equinox in August 2009 (day 223), energetic electrons (110-365 keV) have exhibited a variety of periodic and aperiodic behavior within a spectral window of 5-15 hours. From late 2009 through the end of 2010, when the observed at dusk, a single period near 10.7 hours dominated the Lomb spectra of these particles. Near the end of 2010, however, the energetic electrons displayed multiple periods, with the strongest at 10.65 hours. The periodicity observed after equinox has a mean value of 10.69 ± 0.06 hours and agreed closely with that of Saturn kilometric radio (south) emissions. By early 2011, when the observer had moved to the dayside, the periodicities abruptly disappeared and the Lomb spectra show no periodicity. This behavior may suggest changes in Saturn's ionosphere as a result of seasonal change, or may alternately imply a local time dependence of periodicity caused by magnetodisk thickness asymmetry.

  9. A model for periodic blazars

    NASA Astrophysics Data System (ADS)

    Sobacchi, Emanuele; Sormani, Mattia C.; Stamerra, Antonio

    2017-02-01

    We describe a scenario to explain blazar periodicities with time-scales of ˜ few years. The scenario is based on a binary supermassive black hole (SMBH) system in which one of the two SMBHs carries a jet. We discuss the various mechanisms that can cause the jet to precess and produce corkscrew patterns through space with a scale of ˜ few pc. It turns out that the dominant mechanism responsible for the precession is simply the imprint of the jet-carrying SMBH orbital speed on the jet. Gravitational deflection and Lense-Thirring precession (due to the gravitational field of the other SMBH) are second-order effects. We complement the scenario with a kinematical jet model which is inspired to the spine-sheath structure observed in M87. One of the main advantages of such a structure is that it allows the peak of the synchrotron emission to scale with frequency according to νF ∝ νξ as the viewing angle is changed, where ξ is not necessarily 3 or 4 as in the case of jets with uniform velocity, but can be ξ ˜ 1. Finally, we apply the model to the source PG1553+113, which has been recently claimed to show a Tobs = (2.18 ± 0.08) yr periodicity. We are able to reproduce the optical and gamma-ray light curves and multiple synchrotron spectra simultaneously. We also give estimates of the source mass and size.

  10. On the origin of period changes in RR Lyrae stars

    NASA Technical Reports Server (NTRS)

    Renzini, A.; Sweigart, A. V.

    1980-01-01

    The observed period changes are explained with respect to the behavior of the semiconductive zone (SCZ) within the core of an RR Lyrae star. General consideration are given which suggest that the composition changes occuring within the SCZ during the horizontal-branch evolution result from many small mixing events, each of which slightly perturbs the pulsation period. Results indicate that small mixing events within the core of an RR Lyrae star can produce changes in the pulsation period comparable with those typically observed. It is further indicated that these mixing events together with the nuclear burning between them can produce period changes of both signs.

  11. Third Stokes parameter emission from a periodic water surface

    NASA Technical Reports Server (NTRS)

    Johnson, J. T.; Kong, J. A.; Shin, R. T.; Staelin, D. H.; Oneill, K.; Lohanick, A.

    1991-01-01

    An experiment in which the third Stokes parameter thermal emission from a periodic water surface was measured is documented. This parameter is shown to be related to the direction of periodicity of the periodic surface and to approach brightnesses of up to 30 K at X band for the surface used in the experiment. The surface actually analyzed was a 'two-layer' periodic surface; the theory of thermal emission from such a surface is derived and the theoretical results are found to be in good agreement with the experimental measurements. These results further the idea of using the third Stokes parameter emission as an indicator of wind direction over the ocean.

  12. Periodic cometary showers: Real or imaginary?

    NASA Technical Reports Server (NTRS)

    Grieve, R. A. F.; Sharpton, V. L.; Goodacre, A. K.; Garvin, J. B.

    1985-01-01

    Since the initial reports in 1980, a considerable body of chemical and physical evidence has been accumulated to indicate that a major impact event occurred on earth 65 million years ago. The effects of this event were global in extent and have been suggested as the cause of the sudden demise or mass extinction of a large percentage of life, including the dinosaurs, at the end of the geologic time period known as the Cretaceous. Recent statistical analyses of extinctions in the marine faunal record for the last 250 million years have suggested that mass extinctions may occur with a periodicity of every 26 to 30 million years. Following these results, other workers have attempted to demonstrate that these extinction events, like that at the end of the Cretaceous, are temporally correlated with large impact events. A recent scenario suggests that they are the result of periodic showers of comets produced by either the passage of the solar system through the galactic plane or by perturbations of the cometary cloud in the outer solar system by a, as yet unseen, solar companion. This hypothesized solar companion has been given the name Nemesis.

  13. Population structure of the Classic period Maya.

    PubMed

    Scherer, Andrew K

    2007-03-01

    This study examines the population structure of Classic period (A.D. 250-900) Maya populations through analysis of odontometric variation of 827 skeletons from 12 archaeological sites in Mexico, Guatemala, Belize, and Honduras. The hypothesis that isolation by distance characterized Classic period Maya population structure is tested using Relethford and Blangero's (Hum Biol 62 (1990) 5-25) approach to R matrix analysis for quantitative traits. These results provide important biological data for understanding ancient Maya population history, particularly the effects of the competing Tikal and Calakmul hegemonies on patterns of lowland Maya site interaction. An overall F(ST) of 0.018 is found for the Maya area, indicating little among-group variation for the Classic Maya sites tested. Principal coordinates plots derived from the R matrix analysis show little regional patterning in the data, though the geographic outliers of Kaminaljuyu and a pooled Pacific Coast sample did not cluster with the lowland Maya sites. Mantel tests comparing the biological distance matrix to a geographic distance matrix found no association between genetic and geographic distance. In the Relethford-Blangero analysis, most sites possess negative or near-zero residuals, indicating minimal extraregional gene flow. The exceptions were Barton Ramie, Kaminaljuyu, and Seibal. A scaled R matrix analysis clarifies that genetic drift is a consideration for understanding Classic Maya population structure. All results indicate that isolation by distance does not describe Classic period Maya population structure.

  14. The Mid-Term Results of Patients who Underwent Radiofrequency Atrial Fibrillation Ablation Together with Mitral Valve Surgery

    PubMed Central

    Çolak, Abdurrahim; Kaya, Ugur; Ceviz, Munacettin; Becit, Necip; Kocak, Hikmet

    2016-01-01

    Objetive Saline-irrigated radiofrequency ablation, which has been widely used for surgical treatment of atrial fibrillation in recent years, is 80-90% successful in achieving sinus rhythm. In our study, our surgical experience and mid-term results in patients who underwent mitral valve surgery and left atrial radiofrequency ablation were analyzed. Methods Forty patients (15 males, 25 females; mean age 52.05±9.9 years; range 32-74) underwent surgery for atrial fibrillation associated with mitral valvular disease. All patients manifested atrial fibrillation, which started at least six months before the surgical intervention. The majority of patients (36 patients, 90%) were in NYHA class III; 34 (85%) patients had rheumatic heart disease. In addition to mitral valve surgery and radiofrequency ablation, coronary artery bypass, DeVega tricuspid annuloplasty, left ventricular aneurysm repair, and left atrial thrombus excision were performed. Following discharge from the hospital, patients' follow-up was performed as outpatient clinic examinations and the average follow-up period of patients was 18±3 months. Results While the incidence of sinus rhythm was 85.3% on the first postoperative day, it was 80% during discharge and 71% in the 1st year follow-up examination. Conclusion Radiofrequency ablation is an effective method when it is performed by appropriate surgical technique. Its rate for returning to sinus rhythm is as high as the rate of conventional surgical procedure. PMID:27849303

  15. Genetics Home Reference: hypokalemic periodic paralysis

    MedlinePlus

    ... Home Health Conditions hypokalemic periodic paralysis hypokalemic periodic paralysis Enable Javascript to view the expand/collapse boxes. ... PDF Open All Close All Description Hypokalemic periodic paralysis is a condition that causes episodes of extreme ...

  16. Genetics Home Reference: hyperkalemic periodic paralysis

    MedlinePlus

    ... Home Health Conditions hyperkalemic periodic paralysis hyperkalemic periodic paralysis Enable Javascript to view the expand/collapse boxes. ... PDF Open All Close All Description Hyperkalemic periodic paralysis is a condition that causes episodes of extreme ...

  17. Dynamics of Long-period Comets

    NASA Technical Reports Server (NTRS)

    Weissman, P. R.

    1985-01-01

    Dynamical studies of the origin and evolution of long period comets in the Oort cloud during the past year have concentrated on four areas: (1) interpretation of IRAS observations of dust shells around Vega and some 40 other main sequence stars as evidence for cometary clouds around each of these stars; (2) the dynamical plausibility of an unseen solar companion star orbiting in the Oort cloud and causing periodic cometary showers which result in biological extinction events on the earth; (3) a review of the current hypotheses for cometary formation with particular attention to how each mechanism supplies the required mass of comets to the Oort cloud; and (4) development of new dynamics software to simulate the passage of individual stars directly through the Oort cloud. Each of these efforts is described in detail.

  18. Cholestasis beyond the Neonatal and Infancy Periods

    PubMed Central

    Khalaf, Racha; Phen, Claudia; Karjoo, Sara

    2016-01-01

    Cholestasis results from impairment in the excretion of bile, which may be due to mechanical obstruction of bile flow or impairment of excretion of bile components into the bile canaliculus. When present, cholestasis warrants prompt diagnosis and treatment. The differential diagnosis of cholestasis beyond the neonatal period is broad and includes congenital and acquired etiologies. It is imperative that the clinician differentiates between intrahepatic and extrahepatic origin of cholestasis. Treatment may be supportive or curative and depends on the etiology. Recent literature shows that optimal nutritional and medical support also plays an integral role in the management of pediatric patients with chronic cholestasis. This review will provide a broad overview of the pathophysiology, diagnostic approach, and management of cholestasis beyond the neonatal and infancy periods. PMID:27066444

  19. Chaos computing in terms of periodic orbits.

    PubMed

    Kia, Behnam; Spano, Mark L; Ditto, William L

    2011-09-01

    The complex dynamics of chaotic systems can perform computations. The parameters and/or the initial conditions of a dynamical system are the data inputs and the resulting system state is the output of the computation. By controlling how inputs are mapped to outputs, a specific function can be performed. Previously no clear connection has been drawn between the structure of the dynamics and the computation. In this paper we demonstrate how chaos computation can be explained, modeled, and even predicted in terms of the dynamics of the underlying chaotic system, specifically the periodic orbit structure of the system. Knowing the dynamical equations of the system, we compute the system's periodic orbits as well as its stability in terms of its eigenvalues, thereby demonstrating how, how well, and what the chaotic system can compute.

  20. Ultrasonic geometrical characterization of periodically corrugated surfaces.

    PubMed

    Liu, Jingfei; Declercq, Nico F

    2013-04-01

    Accurate characterization of the characteristic dimensions of a periodically corrugated surface using ultrasonic imaging technique is investigated both theoretically and experimentally. The possibility of accurately characterizing the characteristic dimensions is discussed. The condition for accurate characterization and the quantitative relationship between the accuracy and its determining parameters are given. The strategies to avoid diffraction effects instigated by the periodical nature of a corrugated surface are also discussed. Major causes of erroneous measurements are theoretically discussed and experimentally illustrated. A comparison is made between the presented results and the optical measurements, revealing acceptable agreement. This work realistically exposes the capability of the proposed ultrasonic technique to accurately characterize the lateral and vertical characteristic dimensions of corrugated surfaces. Both the general principles developed theoretically as well as the proposed practical techniques may serve as useful guidelines to peers.

  1. Renormalization transformation of periodic and aperiodic lattices

    SciTech Connect

    Macia, Enrique; Rodriguez-Oliveros, Rogelio

    2006-10-01

    In this work we introduce a similarity transformation acting on transfer matrices describing the propagation of elementary excitations through either periodic or Fibonacci lattices. The proposed transformation can act at two different scale lengths. At the atomic scale the transformation allows one to express the systems' global transfer matrix in terms of an equivalent on-site model one. Correlation effects among different hopping terms are described by a series of local phase factors in that case. When acting on larger scale lengths, corresponding to short segments of the original lattice, the similarity transformation can be properly regarded as describing an effective renormalization of the chain. The nature of the resulting renormalized lattice significantly depends on the kind of order (i.e., periodic or quasiperiodic) of the original lattice, expressing a delicate balance between chemical complexity and topological order as a consequence of the renormalization process.

  2. Ground states for nonuniform periodic Ising chains

    NASA Astrophysics Data System (ADS)

    Martínez-Garcilazo, J. P.; Ramírez, C.

    2015-04-01

    We generalize Morita's works [J. Phys. A 7, 289 (1974), 10.1088/0305-4470/7/2/014; J. Phys. A 7, 1613 (1974), 10.1088/0305-4470/7/13/015] on ground states of Ising chains, for chains with a periodic structure and different spins, to any interaction order. The main assumption is translational invariance. The length of the irreducible blocks is a multiple of the period of the chain. If there is parity invariance, it restricts the length in general only in the diatomic case. There are degenerated states and under certain circumstances there could be nonregular ground states. We illustrate the results and give the ground state diagrams in several cases.

  3. [HYPP--hyperkalemic periodic paralysis in horses].

    PubMed

    Zeilmann, M

    1993-12-01

    A literature review of the clinical syndrome HYPP (Hyperkalemic periodic paralysis) affecting Quarter Horses is given. HYPP is characterized by sporadic attacks of muscle tremors, weakness and/or collapse, lasting for variable periods of time. Diagnosis is based on physical findings in association with hyperkalemia. In horses with HYPP, the regulation of ion transport through the sodium channels in the muscle cells occasionally fails, causing uncontrollable muscle twitching. Further investigations into molecular genetics reveals a mutation in the gene responsible for sodium and potassium regulation. The identification of this gene mutation is the basis for the blood test used to diagnose HYPP. HYPP is inherited as an autosomal dominant trait. Treatment of HYPP attacks by intravenous application of calcium gluconate, bicarbonate and glucose results in rapid recovery. Consequent dietary management and daily administration of acetazolamide effectively controls the disease.

  4. Laser-induced periodic surface structures: Fingerprints of light localization

    NASA Astrophysics Data System (ADS)

    Skolski, J. Z. P.; Römer, G. R. B. E.; Obona, J. V.; Ocelik, V.; Huis in't Veld, A. J.; de Hosson, J. Th. M.

    2012-02-01

    The finite-difference time-domain (FDTD) method is used to study the inhomogeneous absorption of linearly polarized laser radiation below a rough surface. The results are first analyzed in the frequency domain and compared to the efficacy factor theory of Sipe and coworkers. Both approaches show that the absorbed energy shows a periodic nature, not only in the direction orthogonal to the laser polarization, but also in the direction parallel to it. It is shown that the periodicity is not always close to the laser wavelength for the perpendicular direction. In the parallel direction, the periodicity is about λ/Re(ñ), with ñ being the complex refractive index of the medium. The space-domain FDTD results show a periodicity in the inhomogeneous energy absorption similar to the periodicity of the low- and high-spatial-frequency laser-induced periodic surface structures depending on the material's excitation.

  5. 7 CFR 1230.621 - Voting period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE PORK PROMOTION, RESEARCH, AND... term Voting period means the 3-consecutive business day period for in-person voting. Referendum...

  6. Water repellent periodic mesoporous organosilicas.

    PubMed

    Wang, Wendong; Grozea, Daniel; Kohli, Sandeep; Perovic, Douglas D; Ozin, Geoffrey A

    2011-02-22

    This paper demonstrates for the first time thermally induced gradual hydrophobization, monitored quantitatively by ellipsometric porosimetry, of four prototypical periodic mesoporous organosilicas (PMOs) that are tailored through materials chemistry for use as low-dielectric-constant (low k) materials in microprocessors. Theoretical aspects of this quantification are briefly discussed. A comparison of structural, mechanical, dielectric, and hydrophobic properties of ethane, methane, ethene, and 3-ring PMOs is made. Particularly, ethane, methane, and 3-ring PMOs show impressive water repellency at post-treatment temperatures as low as 350 °C, with corresponding Young's modulus values greater than 10 GPa and k values smaller than 2, a figure of merit that satisfies the technological requirements of future generation microchips.

  7. Monteggia-like lesions – treatment strategies and one-year results

    PubMed Central

    Laun, Reinhold; Wild, Michael; Brosius, Lars; Hakimi, Mohssen

    2015-01-01

    Introduction: The eponym “Monteggia fracture” includes various patterns of complex fracture-dislocations of the proximal ulna and radius, which are not well defined yet. They are frequently described as Monteggia-like lesions or Monteggia equivalent injuries. Until today, these injury patterns have been reported rarely. The objective of this retrospective study was to better define patterns of injury and to document the short-term results of treatment with current fixation techniques. Methods: Ten patients with a Monteggia-like lesion were included in this study and clinical and radiological follow-up examinations at an average of 12.3 months after the trauma were performed. For clinical follow-up the Mayo Modified Wrist Score, the Mayo Elbow Performance Score, the functional rating index of Broberg and Morrey, and the DASH score were utilized. Results: Osteosynthesis of the ulna was performed using a proximally contoured or precontoured LCP (locking compression plate) in all patients. All patients had a fracture of the radial head. All patients with a Mason type III radial head fracture received a cemented bipolar radial head prosthesis. All Mason type II fractures were treated with open reduction and internal fixation using mini screws. In all Mason type I fractures the treatment of the radial head dislocation was by closed reduction. Associated coronoid fractures were stabilized with lag screws through the ulnar plate or with independent lag screws after reduction of the fracture. According to the aforementioned scoring systems good to excellent results could be achieved. Conclusions: Our findings demonstrate that good or excellent short-term results can be obtained if the injury is classified correctly and a standardized surgical treatment of all components of the injury is achieved. Further studies with larger patient populations and longer follow up periods are needed to evaluate long-term effectiveness of this treatment concept. PMID:26734535

  8. Acute and Subacute Oral Toxicity of Periodate in Rats

    DTIC Science & Technology

    2014-11-17

    sodium periodate via oral gavage resulted in a cascade of effects that were secondary to kidney toxicity. Decreased mass of ovaries and epididymides and...testicular degeneration were observed in sodium periodate groups with signs of kidney toxicity. These groups also exhibited decreased T3 and T4 in the...presence of decreased TSH, a pattern associated with uremia. Sodium periodate exposed rats exhibited both activation of the innate immune system and

  9. Skill of real-time operational forecasts with the APCC multi-model ensemble prediction system during the period 2008-2015

    NASA Astrophysics Data System (ADS)

    Min, Young-Mi; Kryjov, Vladimir N.; Oh, Sang Myeong; Lee, Hyun-Ju

    2017-02-01

    This paper assesses the real-time 1-month lead forecasts of 3-month (seasonal) mean temperature and precipitation on a monthly basis issued by the Asia-Pacific Economic Cooperation Climate Center (APCC) for 2008-2015 (8 years, 96 forecasts). It shows the current level of the APCC operational multi-model prediction system performance. The skill of the APCC forecasts strongly depends on seasons and regions that it is higher for the tropics and boreal winter than for the extratropics and boreal summer due to direct effects and remote teleconnections from boundary forcings. There is a negative relationship between the forecast skill and its interseasonal variability for both variables and the forecast skill for precipitation is more seasonally and regionally dependent than that for temperature. The APCC operational probabilistic forecasts during this period show a cold bias (underforecasting of above-normal temperature and overforecasting of below-normal temperature) underestimating a long-term warming trend. A wet bias is evident for precipitation, particularly in the extratropical regions. The skill of both temperature and precipitation forecasts strongly depends upon the ENSO strength. Particularly, the highest forecast skill noted in 2015/2016 boreal winter is associated with the strong forcing of an extreme El Nino event. Meanwhile, the relatively low skill is associated with the transition and/or continuous ENSO-neutral phases of 2012-2014. As a result the skill of real-time forecast for boreal winter season is higher than that of hindcast. However, on average, the level of forecast skill during the period 2008-2015 is similar to that of hindcast.

  10. [Suicides in Bjelovar-Bilogora County in the war period, pre-war and post-war period, and the period of the economic expansion and recession].

    PubMed

    Catipović, Vinko; Koić, Elvira; Sklebar, Duška

    2014-01-01

    In the sample of 1134 suicides committed in the period 1988-2011 in Bjelovar-Bilogora County, we have analyzed the number of suicides, methods, scene and time of committing, gender, age and probable motives, comparing results from the Homeland war period, pre-war and post-war period, and the period of the economic expansion and recession. The study results show increase in the suicide rate in wartime and stagnation in the period of the recession. Age-standardized suicide rates for all ages are higher than the Croatian average. Men commit suicides more than women, and 3.53% of the total number of suicides are committed by minors. The most frequent method of performing suicide was by hanging, most suicides were committed in the morning hours, in the spring months, in closed buildings (houses, outbuildings), the most probable motive for suicide is a disease. Seen by periods, suicide rate is the highest in the wartime, with an increase in the percentage of suicides committed by firearms and explosives, and outdoor committed suicides. During the period of the expansion and the recession, we note a shift of suicides toward people in their fifties. The ratio of male and female suicides is the highest in the periods of crisis.

  11. Mining approximate periodic pattern in hydrological time series

    NASA Astrophysics Data System (ADS)

    Zhu, Y. L.; Li, S. J.; Bao, N. N.; Wan, D. S.

    2012-04-01

    There is a lot of information about the hidden laws of nature evolution and the influences of human beings activities on the earth surface in long sequence of hydrological time series. Data mining technology can help find those hidden laws, such as flood frequency and abrupt change, which is useful for the decision support of hydrological prediction and flood control scheduling. The periodic nature of hydrological time series is important for trend forecasting of drought and flood and hydraulic engineering planning. In Hydrology, the full period analysis of hydrological time series has attracted a lot of attention, such as the discrete periodogram, simple partial wave method, Fourier analysis method, and maximum entropy spectral analysis method and wavelet analysis. In fact, the hydrological process is influenced both by deterministic factors and stochastic ones. For example, the tidal level is also affected by moon circling the Earth, in addition to the Earth revolution and its rotation. Hence, there is some kind of approximate period hidden in the hydrological time series, sometimes which is also called the cryptic period. Recently, partial period mining originated from the data mining domain can be a remedy for the traditional period analysis methods in hydrology, which has a loose request of the data integrity and continuity. They can find some partial period in the time series. This paper is focused on the partial period mining in the hydrological time series. Based on asynchronous periodic pattern and partial period mining with suffix tree, this paper proposes to mine multi-event asynchronous periodic pattern based on modified suffix tree representation and traversal, and invent a dynamic candidate period intervals adjusting method, which can avoids period omissions or waste of time and space. The experimental results on synthetic data and real water level data of the Yangtze River at Nanjing station indicate that this algorithm can discover hydrological

  12. Optical properties of structures composed of periodic, quasi-periodic, and aperiodic sequences of particulate monolayers

    NASA Astrophysics Data System (ADS)

    Loiko, V. A.; Miskevich, A. A.

    2017-01-01

    The spectra of the coherent transmission and reflection coefficients of multilayers consisting of the periodic, Fibonacci (quasi-periodic), and Thue-Morse (aperiodic) sequences of plane-parallel monolayers of monodisperse spherical alumina and silica particles are investigated using the quasi-crystalline approximation (QCA) and the transfer matrix method (TMM). The additional opportunities for the transmission and reflection spectra manipulation in comparison with the periodic sequence of monolayers are demonstrated. Photonic band gaps in the spectra of the particulate structures are shifted to the short-wavelength range in comparison with those for systems of homogeneous layers. The shift is larger for the Thue-Morse sequence. The widths of the photonic band gaps for particulate systems are narrower than the ones for multilayers consisting of homogeneous layers of an equivalent volume of matter. The results can be used to create optical, optoelectronics, and photonics devices—for example, multispectral filters, light emitting diodes, solar cells, displays.

  13. Periodicity of nuclear morphology in human fibroblasts

    PubMed Central

    Seaman, Laura; Meixner, Walter; Snyder, John; Rajapakse, Indika

    2015-01-01

    Motivation: Morphology of the cell nucleus has been used as a key indicator of disease state and prognosis, but typically without quantitative rigor. It is also not well understood how nuclear morphology varies with time across different genetic backgrounds in healthy cells. To help answer these questions we measured the size and shape of nuclei in cell-cycle-synchronized primary human fibroblasts from 6 different individuals at 32 time points over a 75 hour period. Results: The nucleus was modeled as an ellipsoid and its dynamics analyzed. Shape and volume changed significantly over this time. Two prominent frequencies were found in the 6 individuals: a 17 hour period consistent with the cell cycle and a 26 hour period. Our findings suggest that the shape of the nucleus changes over time and thus any time-invariant shape property may provide a misleading characterization of cellular populations at different phases of the cell cycle. The proposed methodology provides a general method to analyze morphological change using multiple time points even for non-live-cell experiments. PMID:26734724

  14. Magnetoacoustic nonlinear periodic (cnoidal) waves in plasmas

    NASA Astrophysics Data System (ADS)

    Ur-Rehman, Hafeez; Mahmood, S.; Hussain, S.

    2017-01-01

    Magnetoacoustic nonlinear periodic (cnoidal) waves and solitons are studied in magnetized electron-ion plasmas with inertial cold ions and warm electrons. Using the two fluid model, the dispersion relation of the magnetoacoustic waves is obtained in the linear limit and the wave dispersive effects appear through the electron inertial length. The well known reductive perturbation method is employed to derive the Korteweg-de Vries equation for magnetoacoustic waves in plasmas. The Sagdeev potential approach is used, and the cnoidal wave solution of magnetoacoustic waves is obtained under periodic boundary conditions. The analytical solution for magnetoacoustic solitons is also presented. The phase plane portraits are also plotted for magnetoacoustic solitons shown as a separatrix, and the cnoidal wave structure always lies within the separatrix. It is found that plasma beta, which depends on the plasma density, electron temperature, and magnetic field intensity, has a significant effect on the amplitude and phase of the cnoidal waves, while it also affects the width and amplitude of the magnetoacoustic soliton in plasmas. The numerical results are plotted within the plasma parameters for laboratory and space plasmas for illustration. It is found that only compressive magnetoacoustic nonlinear periodic wave and soliton structures are formed in magnetized plasmas.

  15. Quantum periods of Calabi-Yau fourfolds

    NASA Astrophysics Data System (ADS)

    Gerhardus, Andreas; Jockers, Hans

    2016-12-01

    In this work we study the quantum periods together with their Picard-Fuchs differential equations of Calabi-Yau fourfolds. In contrast to Calabi-Yau threefolds, we argue that the large volume points of Calabi-Yau fourfolds generically are regular singular points of the Picard-Fuchs operators of non-maximally unipotent monodromy. We demonstrate this property in explicit examples of Calabi-Yau fourfolds with a single Kähler modulus. For these examples we construct integral quantum periods and study their global properties in the quantum Kähler moduli space with the help of numerical analytic continuation techniques. Furthermore, we determine their genus zero Gromov-Witten invariants, their Klemm-Pandharipande meeting invariants, and their genus one BPS invariants. In our computations we emphasize the features attributed to the non-maximally unipotent monodromy property. For instance, it implies the existence of integral quantum periods that at large volume are purely worldsheet instanton generated. To verify our results, we also present intersection theory techniques to enumerate lines with a marked point on complete intersection Calabi-Yau fourfolds in Grassmannian varieties.

  16. Limiting rotational period of neutron stars

    NASA Astrophysics Data System (ADS)

    Glendenning, Norman K.

    1992-11-01

    We seek an absolute limit on the rotational period for a neutron star as a function of its mass, based on the minimal constraints imposed by Einstein's theory of relativity, Le Chatelier's principle, causality, and a low-density equation of state, uncertainties in which can be evaluated as to their effect on the result. This establishes a limiting curve in the mass-period plane below which no pulsar that is a neutron star can lie. For example, the minimum possible Kepler period, which is an absolute limit on rotation below which mass shedding would occur, is 0.33 ms for a M=1.442Msolar neutron star (the mass of PSR1913+16). A still lower curve, based only on the structure of Einstein's equations, limits any star whatsoever to lie in the plane above it. Hypothetical stars such as strange stars, if the matter of which they are made is self-bound in bulk at a sufficiently large equilibrium energy density, can lie in the region above the general-relativistic forbidden region, and in the region forbidden to neutron stars.

  17. Limiting rotational period of neutron stars

    SciTech Connect

    Glendenning, N.K. )

    1992-11-15

    We seek an absolute limit on the rotational period for a neutron star as a function of its mass, based on the minimal constraints imposed by Einstein's theory of relativity, Le Chatelier's principle, causality, and a low-density equation of state, uncertainties in which can be evaluated as to their effect on the result. This establishes a limiting curve in the mass-period plane below which no pulsar that is a neutron star can lie. For example, the minimum possible Kepler period, which is an absolute limit on rotation below which mass shedding would occur, is 0.33 ms for a {ital M}=1.442{ital M}{sub {circle dot}} neutron star (the mass of PSR1913+16). A still lower curve, based only on the structure of Einstein's equations, limits any star whatsoever to lie in the plane above it. Hypothetical stars such as strange stars, if the matter of which they are made is self-bound in bulk at a sufficiently large equilibrium energy density, can lie in the region above the general-relativistic forbidden region, and in the region forbidden to neutron stars.

  18. 34 CFR 75.251 - Budget periods.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 1 2014-07-01 2014-07-01 false Budget periods. 75.251 Section 75.251 Education Office...-Year Projects § 75.251 Budget periods. (a) The Secretary usually approves a budget period of not more... multi-year project period, the Secretary: (1) Makes a grant to the project for the initial budget...

  19. 7 CFR 959.16 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 959.16 Section 959.16 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Regulating Handling Definitions § 959.16 Fiscal period. Fiscal period means the annual period beginning...

  20. 7 CFR 945.12 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 945.12 Section 945.12 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Fiscal period. Fiscal period means the period beginning and ending on the dates approved by the...

  1. 7 CFR 1230.9 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Fiscal period. 1230.9 Section 1230.9 Agriculture... CONSUMER INFORMATION Pork Promotion, Research, and Consumer Information Order Definitions § 1230.9 Fiscal period. Fiscal period means the 12-month period ending on December 31 or such other consecutive...

  2. 7 CFR 947.9 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 947.9 Section 947.9 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Definitions § 947.9 Fiscal period. Fiscal period means the period beginning and ending on the dates...

  3. 7 CFR 948.103 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 948.103 Section 948.103 Agriculture... Rules and Regulations General § 948.103 Fiscal period. Pursuant to § 948.10, the fiscal periods for each... following year, both dates inclusive. The 1986-87 fiscal period which began July 1, 1986, will be...

  4. 7 CFR 948.10 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 948.10 Section 948.10 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Regulating Handling Definitions § 948.10 Fiscal period. Fiscal period means the period...

  5. 7 CFR 953.122 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 953.122 Section 953.122 Agriculture... STATES Rules and Regulations Change in Date for Completing Nominations, Term of Office, and Fiscal Period § 953.122 Fiscal period. The fiscal period, pursuant to § 953.9, which began on April 1, 1976, shall...

  6. 7 CFR 956.113 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 956.113 Section 956.113 Agriculture... VALLEY OF SOUTHEAST WASHINGTON AND NORTHEAST OREGON Rules and Regulations § 956.113 Fiscal period. Pursuant to § 956.13, fiscal period shall mean the period beginning January 1 and ending December 31...

  7. 7 CFR 958.12 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 958.12 Section 958.12 Agriculture... COUNTIES IN IDAHO, AND MALHEUR COUNTY, OREGON Order Regulating Handling Definitions § 958.12 Fiscal period. Fiscal period means the period beginning and ending on the dates approved by the Secretary pursuant...

  8. 7 CFR 946.9 - Fiscal period.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Fiscal period. 946.9 Section 946.9 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Order Regulating Handling Definitions § 946.9 Fiscal period. Fiscal period means the period beginning...

  9. Quasi-periodic pulsations with periods that change depending on whether the pulsations have thermal or nonthermal components

    NASA Astrophysics Data System (ADS)

    Li, D.; Zhang, Q. M.; Huang, Y.; Ning, Z. J.; Su, Y. N.

    2017-01-01

    Context. Quasi-periodic pulsations (QPPs) typically display periodic and regular peaks in the light curves during the flare emissions. Sometimes, QPPs show multiple periods at the same wavelength. However, changing periods in various channels are rare. Aims: We report QPPs in a solar flare on 2014 October 27. They showed a period change that depended on whether thermal or nonthermal components were included. The flare was simultaneously observed by many instruments. Methods: Using the fast Fourier transform (FFT), we decomposed the light curves at multiple wavelengths into slowly varying and rapidly varying signals. Then we identified the QPPs as the regular and periodic peaks from the rapidly varying signals. The periods are derived with the wavelet method and confirmed based on the FFT spectra of the rapidly varying signals. Results: We find a period of 50 s from the thermal emissions during the impulsive phase of the flare, that is, in the soft X-ray bands. At the same time, a period of about 100 s is detected from the nonthermal emissions, such as hard X-ray and microwave channels. The period ratio is exactly 2.0, which might be due to the modulations of the magnetic reconnection rate by the fundamental and harmonic modes of magnetohydrodynamic waves. Our results further show that the 100 s period is present over a broad wavelength, such as hard X-rays, extreme-UV/UV, and microwave emissions, indicating the periodic magnetic reconnection in this flare. Conclusions: To our knowledge, this is the first report about period changes from thermal to nonthermal components in a single flare that occur at almost the same time. This new observational finding could be a challenge to the theory of flare QPPs.

  10. First Results of GPS Time Transfer to Australia

    NASA Technical Reports Server (NTRS)

    Mck.luck, J.; Woodger, J. R.; Wells, J. E.; Churchill, P. N.; Clements, P. A.

    1984-01-01

    A global positioning system (GPS) time transfer unit was installed at Tidbinbilla Deep Space Communications Complex of the DSN in June 1983. It was used to estimate the relationship to UTC(USNO MC) of the Tidbinbilla frequency and time system TID(FTS) based on a hydrogen maser, and to estimate the performance of the Australian free-running time scale UTC(AUS). Data from the first 3 months were analyzed three ways: by two-hop common view using JPL as intermediary; by long-arc interpolation of measurements against space vehicle clocks; and by long arc interpolation of GPS-Time results. Residuals from a single quadratic fit through 3 months of UTC(USNO MC) -TID(FTS) results were white noise with standard error 15 ns, and a flying clock measurement gave 70 ns agreement. A straight line fit through results UTC(USNO MC) - UTC(AUS) gave 90 ns standard error and 120 ns agreement. It is proposed to use the GPS measurements to steer UTC(AUS) to UTC(BIH), and to rename the existing time scale TA(AUS).

  11. Epigenetics in the perioperative period

    PubMed Central

    Lirk, P; Fiegl, H; Weber, N C; Hollmann, M W

    2015-01-01

    The perioperative period is characterized by profound changes in the body's homoeostatic processes. This review seeks to address whether epigenetic mechanisms may influence an individual's reaction to surgery and anaesthesia. Evidence from animal and human studies suggests that epigenetic mechanisms can explain many facets of susceptibility to acute and chronic pain, making them potential therapeutic targets. Modern pain management is still based upon opiates, and both the developmental expression of opioid receptors and opioid-induced hyperalgesia have been linked to epigenetic mechanisms. In general, opiates seem to increase global DNA methylation levels. This is in contrast to local anaesthetics, which have been ascribed a global demethylating effect. Even though no direct investigations have been carried out, the potential influence of epigenetics on the inflammatory response that follows surgery seems a promising area for research. There is a considerable body of evidence that supports the involvement of epigenetics in the complex process of wound healing. Epigenetics is an important emerging research topic in perioperative medicine, with a huge potential to positively influence patient outcome. PMID:25073649

  12. Production of a Periodical Index by a Special Library.

    ERIC Educational Resources Information Center

    Stewart, Martha M.; Hatton, Jackie L.

    1992-01-01

    Describes the rationale, method, automation developments, and future directions of the "Air University Library Index to Military Periodicals," a subject index to 81 military and aeronautical periodicals. Results of a user survey on the desirability of producing the index on CD-ROM or incorporating it in the library's integrated system…

  13. The effect of multiple encounters on short period comet orbits

    NASA Technical Reports Server (NTRS)

    Lowrey, B. E.

    1972-01-01

    The observed orbital elements of short period comets are found to be consistent with the hypothesis of derivation from long period comets as long as two assumptions are made. First, the distribution of short period comets has been randomized by multiple encounters with Jupiter and second, the short period comets have lower velocities of encounter with Jupiter than is generally expected. Some 16% of the observed short period comets have lower encounter velocities than is allowed mathematically using Laplace's method. This may be due to double encounter processes with Jupiter and Saturn, or as a result of prolonged encounters. The distribution of unobservable short period comets can be inferred in part from the observed comets. Many have orbits between Jupiter and Saturn with somewhat higher inclinations than those with perihelions near the earth. Debris from those comets may form the major component of the zodiacal dust.

  14. Quasi-periodic continuation along a continuous symmetry

    NASA Astrophysics Data System (ADS)

    Salomone, Matthew David

    Given a system of differential equations which admits a continuous group of symmetries and possesses a periodic solution, we show that under certain nondegeneracy assumptions there always exists a continuous family containing infinitely many periodic and quasi-periodic trajectories. This generalizes the continuation method of Poincaré to orbits which are not necessarily periodic. We apply these results in the setting of the Lagrangian N -body problem of homogeneous potential to characterize an infinite family of rotating nonplanar "hip-hop" orbits in the four-body problem of equal masses, and show how some other trajectories in the N -body theory may be extended to infinite families of periodic and quasi-periodic trajectories.

  15. Ciliary Neurotrophic Factor (CNTF) for Macular Telangiectasia Type 2 (MacTel): Results from a phase I safety trial

    PubMed Central

    Chew, Emily Y.; Clemons, Traci E.; Peto, Tunde; Sallo, Ferenc B.; Ingerman, Avner; Tao, Weng; Singerman, Lawrence; Schwartz, Steven D.; Peachey, Neal S.; Bird, Alan C.

    2015-01-01

    PURPOSE To evaluate the safety and tolerability of intraocular delivery of ciliary neurotrophic factor (CNTF) using an encapsulated cell implant for the treatment of macular telangiectasia type 2. DESIGN An open-labeled safety trial conducted in 2 centers enrolling 7 participants with macular telangiectasia type 2. METHODS The participant’s more severely affected eye (worse baseline visual acuity) received the high dose implant of CNTF. Patients were followed for a period of 36 months. The primary safety outcome was a change in the parameters of the electroretinogram (ERG). Secondary efficacy outcomes were changes in visual acuity, en face measurements of the optical coherence tomography of the disruption in the ellipsoid zone, and microperimetry when compared with baseline. RESULTS The ERG findings demonstrated a reduction in the amplitude of the scotopic b-wave in 4 participants 3 months after implantation (month 3). All parameters returned to baseline values by month 12 and remained so at month 36 with no clinical impact on dark adaptation. There was no change in visual acuity compared with baseline. The area of the defect as measured functionally by microperimetry and structurally by the en face OCT imaging of the ellipsoid zone loss appeared unchanged from baseline. CONCLUSIONS The intraocular delivery of CNTF in the encapsulated cell implant appeared to be safe and well tolerated in eyes with macular telangiectasia type 2. Further evaluation in a randomized controlled clinical trial is warranted to test for efficacy. PMID:25528956

  16. The evolution of ultrashort period binary systems

    NASA Technical Reports Server (NTRS)

    Nelson, L. A.; Rappaport, S. A.; Joss, P. C.

    1986-01-01

    A discussion is presented concerning the results of detailed evolutionary calculations in which a very low mass and hydrogen-depleted semiattached binary star containing a collapsed object can reach an exceptionally short orbital period while sustaining a relatively high mass transfer rate. The observed properties of such systems can be understood under the assumption that they contain moderately to severely hydrogen-defficient secondary stars that are neither fully degenerate nor burning He. It is noted that for extremely hydrogen-depleted stars, the assumption of chemical homogeneity becomes untenable. Attention is given to the binary systems 4U 1626-67, 4U 1916-05, and G61-29.

  17. Topological study of the periodic system.

    PubMed

    Restrepo, Guillermo; Mesa, Héber; Llanos, Eugenio J; Villaveces, José L

    2004-01-01

    We carried out a topological study of the Space of Chemical Elements, SCE, based on a clustering analysis of 72 elements, each one defined by a vector of 31 properties. We looked for neighborhoods, boundaries, and other topological properties of the SCE. Among the results one sees the well-known patterns of the Periodic Table and relationships such as the Singularity Principle and the Diagonal Relationship, but there appears also a robustness property of some of the better-known families of elements. Alkaline metals and Noble Gases are sets whose neighborhoods have no other elements besides themselves, whereas the topological boundary of the set of metals is formed by semimetallic elements.

  18. Periodical cicadas: A minimal automaton model

    NASA Astrophysics Data System (ADS)

    de O. Cardozo, Giovano; de A. M. M. Silvestre, Daniel; Colato, Alexandre

    2007-08-01

    The Magicicada spp. life cycles with its prime periods and highly synchronized emergence have defied reasonable scientific explanation since its discovery. During the last decade several models and explanations for this phenomenon appeared in the literature along with a great deal of discussion. Despite this considerable effort, there is no final conclusion about this long standing biological problem. Here, we construct a minimal automaton model without predation/parasitism which reproduces some of these aspects. Our results point towards competition between different strains with limited dispersal threshold as the main factor leading to the emergence of prime numbered life cycles.

  19. 2012 election results

    NASA Astrophysics Data System (ADS)

    Robinson, Robert; Tetzlaff, Doerthe

    2012-10-01

    On 4 October 2012, AGU members completed voting for the 2013-2014 leadership term. Union officers, Board members, section and focus group officers, and student and early career representatives to the Council were elected. All members who joined or renewed their membership by 1 July 2012 were eligible to vote in this year's leadership election. The vote was held electronically, and access to voting was provided to all eligible voters for a period of 31 days. The voting was conducted by Survey and Ballot Systems, Inc. (SBS). SBS, which offers election planning and management services, provided unique login credentials and other support services for eligible voters throughout the election. Voting results were certified by SBS on 8 October and by the AGU Tellers Committee on 9 October. The overall participation rate was 21.9%, an increase over previous AGU elections.

  20. Influence of month and climatic factors on the period of birth, litter size, birth weight and preweaning mortality of sheep in Ghana

    NASA Astrophysics Data System (ADS)

    Kabuga, J. D.; Akowuah, F.

    1990-09-01

    Relationships between month and clinatic factors-rainfall, ambient temperature, relative humidity (RH) and temperature-humidity index (THI)-with time of parturition, litter size, birth weight and preweaning mortality were studied in Djallonke and Dja lonke x Sahelian sheep. Births (4142) occurred all year round although there were significant differences in the number of births per month. Maximum litter size did not coincide with the maximum births. Peak conceptions occurred in the early parts of the major rainy season. There were also significant differences in birth weights and mortalities (%) per month. Maximum and minimum values (of birth weighs and mortalities) occurred in the latter part of the rainy seasons and dry periods respectively. There were significant positive correlations between litter size and cumulative rainfall in the 4th 6th months periods prior to lambing. Birth weights of both males and females were positively and significantly associated with minimum temperature and cumulative rain-fall in the 2- and 3-months period prior to lambing respectively. There were significant positive correlations between mortality and minimum and maximum RH and cumulative rainfall in the 3 months after lambing.

  1. Man Made Elements Periodic Table, Astronomical Periodic Table, Geographic Periodic Table-Dimitri Mendeleev Imitation in the 21st Century

    NASA Astrophysics Data System (ADS)

    Struck, J.-T.

    2013-11-01

    A man made elements periodic table, including every single current element not just synthetic elements can be built differently than the naturally occurring element periodic table. Implications for knowing producible elements in space travel.

  2. Periodicity of Mrk 501 in Optical Wavelengths

    NASA Astrophysics Data System (ADS)

    Rivest, L. Joseph; Osborne, Mckay; Moody, Joseph; Holden, Marcus; Hintz, Eric; Joner, Michael; Jeffery, Elizabeth

    2017-01-01

    We present data for Mrk501 from 2009-2016 taken by ROVOR and WMO in Johnson B, V, and R filters. An aperture of radius 5'' was used for all data. Photometry was referenced to the same ensemble of stars in all frames. We find strong evidence for a regular light curve matching a sine wave of amplitude around 1 ×10-15(ergs-1 cm-2Å-1) in B, 0 . 6 ×10-15(ergs-1 cm-2Å-1) in V, and 0 . 5 ×10-15(ergs-1 cm-2Å-1) in R, and with a period of 2000 +/- 200 days. Additionally, a linear combination of sine waves having periods of 113 +/- 3 days and 70 +/- 5 days also show a strong presence in the light curve, both with amplitudes of around 0 . 25 +/- 0 . 03 ×10-15(ergs-1 cm-2Å-1) in V. These results are consistent with X-ray data and are qualitatively similar to the light curve found for NGC5548 (Bon et al, 2016). We lend these results as potentially bearing further evidence for the presence of a binary super-massive balck hole in Mrk 501.

  3. Computer-based cognitive intervention for dementia: preliminary results of a randomized clinical trial.

    PubMed

    Galante, E; Venturini, G; Fiaccadori, C

    2007-01-01

    Dementia is a highly invalidating condition and, given the progressive aging of the population, one of the major issues that health systems will have to face in future years. Recently there has been an increase in the potential of diagnostic tools and pharmacological treatments for dementia; moreover, considerable interest has been expressed regarding non pharmacological interventions. However, the current evidence in support of non pharmacological treatments in patients affected by dementia still does not allow to draw definitive conclusions on what is the most effective treatment to apply, largely because of methodological difficulties and limitations of the studies so far carried out due to the complex nature of the disease. To address this need, we carried out a single blind randomized controlled study on the efficacy of computer cognitive rehabilitation in patients with mild cognitive decline. We here present preliminary data on 11 patients with diagnosis of Alzheimer's Disease (AD) and mild cognitive decline randomly assigned to treatment (a) or control (b) condition (i.e. specific vs. aspecific treatment). The specific treatment (a) consisted in a cycle of 12 individual sessions of computer exercises, while the control condition (b) consisted in sessions of semi-structured interviews with patients, conducted with the same frequency and time period as (a). Cognitive, behavioural and functional assessment was performed by an expert evaluator, blinded to the patients' group allocation. Preliminary results show a significant performance decline only in the control group at the 9-month follow-up compared to both baseline and the 3-month follow-up. Our results suggest that computer based cognitive training in patients with AD and mild cognitive decline is effective at least in delaying the continuous progression of cognitive impairment in AD.

  4. First continuous flow analysis results from the Greenland ReCAP project

    NASA Astrophysics Data System (ADS)

    Kjær, Helle Astrid

    2016-04-01

    The new Renland ice core was drilled in summer 2015 in Greenland and measured by means of Continuous flow analysis during the last 3 months of 2015. The Renland ice core was obtained as part of the ReCAP project, extending 584.11 meters to the bottom of the Renland ice cap located in east Greenland. The unique position on a mountain saddle above 2000 meters altitude, but close to the coast, ensures that the Renland ice core offers high accumulation, but also reaches far back in time. Preliminary results show that the record holds ice from the past warm interglacial period, the Eemian. The record was analyzed for multiple elements including the forest fire tracers NH4+ and black carbon, insoluble dust particles by means of Abakus laser particle counter and the dust ion Ca2+, sea salt Na and acidity useful for finding volcanic layers to date the core. Further H2O2, and the nutrients Fe and dissolved reactive phosphorus was analyzed as well as the temperature indicator δ18O all by means of continuous flow analysis (CFA). The core was melted at a rate of 3 cm/min providing a temporal resolution for most components determined sufficient to resolve annual layers through the Holocene. The glacial section is strongly thinned, but nonetheless due to the high resolution of the measurements all DO events could be identified. Below the glacial section another ˜20 meters of warm Eemian ice have been analysed. Here we present the first chemistry results as obtained by continuous flow analysis (CFA).

  5. Ixekizumab, an interleukin-17A specific monoclonal antibody, for the treatment of biologic-naive patients with active psoriatic arthritis: results from the 24-week randomised, double-blind, placebo-controlled and active (adalimumab)-controlled period of the phase III trial SPIRIT-P1

    PubMed Central

    Mease, Philip J; Ritchlin, Christopher T; Okada, Masato; Cuchacovich, Raquel S; Shuler, Catherine L; Lin, Chen-Yen; Braun, Daniel K; Lee, Chin H; Gladman, Dafna D

    2017-01-01

    Objective To assess the safety and efficacy of ixekizumab, a monoclonal antibody that inhibits interleukin-17A, in a double-blind phase III trial enrolling patients with active psoriatic arthritis (PsA). Methods Patients naive to biologic therapy with active PsA were randomised to subcutaneous injections of placebo (N=106), adalimumab 40 mg once every 2 weeks (active reference; N=101), ixekizumab 80 mg once every 2 weeks (IXEQ2W) (N=103), or ixekizumab 80 mg once every 4 weeks (IXEQ4W) (N=107). Both ixekizumab regimens included a 160-mg starting dose. The primary objective was to assess the superiority of IXEQ2W or IXEQ4W versus placebo as measured by the proportion of patients achieving an American College of Rheumatology 20 (ACR20) response at week 24. Results Significantly more patients treated with ixekizumab achieved an ACR20 response with IXEQ2W (62.1%) or IXEQ4W (57.9%) than placebo (30.2%) (p≤0.001; non-responder imputation method). Disease activity and functional disability were significantly improved with both ixekizumab doses versus placebo at weeks 12 and 24, and there was significantly less progression of structural damage at week 24 (p≤0.01). Clearance of plaque psoriasis was greater with ixekizumab than placebo (p≤0.001). Efficacy results with adalimumab, the active reference arm, showed significant improvements versus placebo. Treatment-emergent adverse events were more frequent with ixekizumab (65.7–66.4%) and adalimumab (64.4%) than placebo (47.2%) (p<0.05). Conclusions In biologic-naive patients with active PsA, ixekizumab treatment resulted in improvements in disease activity and physical function, as well as in the inhibition of structural damage progression. Overall, adverse events were more frequent in all active groups compared with placebo. Trial registration number NCT01695239; EudraCT2011-002326-49; Results. PMID:27553214

  6. Nonlinear model-based method for clustering periodically expressed genes.

    PubMed

    Tian, Li-Ping; Liu, Li-Zhi; Zhang, Qian-Wei; Wu, Fang-Xiang

    2011-01-01

    Clustering periodically expressed genes from their time-course expression data could help understand the molecular mechanism of those biological processes. In this paper, we propose a nonlinear model-based clustering method for periodically expressed gene profiles. As periodically expressed genes are associated with periodic biological processes, the proposed method naturally assumes that a periodically expressed gene dataset is generated by a number of periodical processes. Each periodical process is modelled by a linear combination of trigonometric sine and cosine functions in time plus a Gaussian noise term. A two stage method is proposed to estimate the model parameter, and a relocation-iteration algorithm is employed to assign each gene to an appropriate cluster. A bootstrapping method and an average adjusted Rand index (AARI) are employed to measure the quality of clustering. One synthetic dataset and two biological datasets were employed to evaluate the performance of the proposed method. The results show that our method allows the better quality clustering than other clustering methods (e.g., k-means) for periodically expressed gene data, and thus it is an effective cluster analysis method for periodically expressed gene data.

  7. Explore Stochastic Instabilities of Periodic Points by Transition Path Theory

    NASA Astrophysics Data System (ADS)

    Cao, Yu; Lin, Ling; Zhou, Xiang

    2016-06-01

    We consider the noise-induced transitions from a linearly stable periodic orbit consisting of T periodic points in randomly perturbed discrete logistic map. Traditional large deviation theory and asymptotic analysis at small noise limit cannot distinguish the quantitative difference in noise-induced stochastic instabilities among the T periodic points. To attack this problem, we generalize the transition path theory to the discrete-time continuous-space stochastic process. In our first criterion to quantify the relative instability among T periodic points, we use the distribution of the last passage location related to the transitions from the whole periodic orbit to a prescribed disjoint set. This distribution is related to individual contributions to the transition rate from each periodic points. The second criterion is based on the competency of the transition paths associated with each periodic point. Both criteria utilize the reactive probability current in the transition path theory. Our numerical results for the logistic map reveal the transition mechanism of escaping from the stable periodic orbit and identify which periodic point is more prone to lose stability so as to make successful transitions under random perturbations.

  8. Efficient generation of periodic and quasi-periodic non-diffractive optical fields with phase holograms.

    PubMed

    Arrizón, Victor; de-la-Llave, David Sánchez; Méndez, Guadalupe; Ruiz, Ulises

    2011-05-23

    The superposition of multiple plane waves with appropriate propagation vectors generates a periodic or quasi-periodic non-diffractive optical field. We show that the Fourier spectrum of the phase modulation of this field is formed by two disjoint parts, one of which is proportional to the Fourier spectrum of the field itself. Based on this result we prove that the non-diffractive field can be generated, with remarkable high accuracy and efficiency, in a Fourier domain spatial filtering setup, using a synthetic phase hologram whose transmittance is the phase modulation of the field. In a couple of cases this result is presented analytically, and in other cases the proof is computational and experimental.

  9. Effects of periodic forcing in chaotic scattering.

    PubMed

    Blesa, Fernando; Seoane, Jesús M; Barrio, Roberto; Sanjuán, Miguel A F

    2014-04-01

    The effects of a periodic forcing on chaotic scattering are relevant in certain situations of physical interest. We investigate the effects of the forcing amplitude and the external frequency in both the survival probability of the particles in the scattering region and the exit basins associated to phase space. We have found an exponential decay law for the survival probability of the particles in the scattering region. A resonant-like behavior is uncovered where the critical values of the frequencies ω≃1 and ω≃2 permit the particles to escape faster than for other different values. On the other hand, the computation of the exit basins in phase space reveals the existence of Wada basins depending of the frequency values. We provide some heuristic arguments that are in good agreement with the numerical results. Our results are expected to be relevant for physical phenomena such as the effect of companion galaxies, among others.

  10. Periodic equatorial water flows from a Hamiltonian perspective

    NASA Astrophysics Data System (ADS)

    Ionescu-Kruse, Delia; Martin, Calin Iulian

    2017-04-01

    The main result of this paper is a Hamiltonian formulation of the nonlinear governing equations for geophysical periodic stratified water flows in the equatorial f-plane approximation allowing for piecewise constant vorticity.

  11. Heat waves and warm periods in Slovakia

    NASA Astrophysics Data System (ADS)

    Faško, Pavel; Bochníček, Oliver; Markovič, Ladislav; Švec, Marek

    2016-04-01

    The scenarios of climate change caused by human activity show that frequency of occurrence and extent of heat waves in the interior of Europe is increasing. Among the most exposed regions in this regard should the area of southeastern and eastern Austria and south-western Slovakia. The relatively faster increase in the number of heat waves in this area is related also to potential desertification in this region just east of the Alps, since during summer, weather fronts advancing from the west are consequently losing their original features and moderating influence. Summer weather patterns for this area should in the future more closely remind climate typical for some inland areas of southwestern, southern and southeastern Europe. A certain shift of climate zones from south to north should thus modify future climate and Slovakia. Despite the complex natural conditions the existing trends derived from results of meteorological measurements and observations are clear and they confirm warming of climate in this region. Observations and measurements in the recent years of the 21st century confirm, that heat waves are no longer rare phenomenon during summer, but are systematically appearing even in colder regions of northern Slovakia. What is very remarkable and will be necessary to pay more attention to, is the fact that these heat waves are expanding into previously unaffected areas, associated with the lack of rainfall and drought, on larger regional scale. In this study heat wave periods and individual heat events and days are statistically identified in the time series characteristics of air temperature at selected meteorological stations for the period from the mid-20th century until 2015, in case of available historical data even for longer period.

  12. The period of susceptibility to the physiological effects of unilateral eye closure in kittens.

    PubMed

    Hubel, D H; Wiesel, T N

    1970-02-01

    1. Kittens were visually deprived by suturing the lids of the right eye for various periods of time at different ages. Recordings were subsequently made from the striate cortex, and responses from the two eyes compared. As previously reported, monocular eye closure during the first few months of life causes a sharp decline in the number of cells that can be influenced by the previously closed eye.2. Susceptibility to the effects of eye closure begins suddenly near the start of the fourth week, remains high until some time between the sixth and eighth weeks, and then declines, disappearing finally around the end of the third month. Monocular closure for over a year in an adult cat produces no detectable effects.3. During the period of high susceptibility in the fourth and fifth weeks eye closure for as little as 3-4 days leads to a sharp decline in the number of cells that can be driven from both eyes, as well as an over-all decline in the relative influence of the previously closed eye. A 6-day closure is enough to give a reduction in the number of cells that can be driven by the closed eye to a fraction of the normal. The physiological picture is similar to that following a 3-month monocular deprivation from birth, in which the proportion of cells the eye can influence drops from 85 to about 7%.4. Cells of the lateral geniculate receiving input from a deprived eye are noticeably smaller and paler to Nissl stain following 3 or 6 days' deprivation during the fourth week.5. Following 3 months of monocular deprivation, opening the eye for up to 5 yr produces only a very limited recovery in the cortical physiology, and no obvious recovery of the geniculate atrophy, even though behaviourally there is some return of vision in the deprived eye. Closing the normal eye, though necessary for behavioural recovery, has no detectable effect on the cortical physiology. The amount of possible recovery in the striate cortex is probably no greater if the period of eye closure is

  13. Periodicities in the north-south asymmetry of solar activity

    NASA Astrophysics Data System (ADS)

    Vizoso, G.; Ballester, J. L.

    1989-09-01

    A Blackman-Tukey power spectrum is performed on the values of the north-south asymmetry in the sudden disappearance of solar prominences, and the results are reported. The findings confirm the proposed existence of a periodicity of around 11 years and fails to confirm another short periodicity of around 2.3 years. The results of the power spectrum performed using values of the flare number and flare index north-south asymmetry provide a significant peak of 3.1-3.2 years. This short periodicity could be related to those found by Ramanuja Rao (1973) in several indices of solar activity.

  14. NMR Shielding and the Periodic Table

    NASA Astrophysics Data System (ADS)

    Gerothanassis, I. P.; Kalodimos, C. G.

    1996-08-01

    The object of this article is to find periodic, structurally significant observables that can be correlated to the nuclear shielding or alternatively to investigate whether chemical shift can be used to intensify the periodic disposition of valence electrons.

  15. Liftings and stresses for planar periodic frameworks

    PubMed Central

    Borcea, Ciprian; Streinu, Ileana

    2015-01-01

    We formulate and prove a periodic analog of Maxwell’s theorem relating stressed planar frameworks and their liftings to polyhedral surfaces with spherical topology. We use our lifting theorem to prove deformation and rigidity-theoretic properties for planar periodic pseudo-triangulations, generalizing features known for their finite counterparts. These properties are then applied to questions originating in mathematical crystallography and materials science, concerning planar periodic auxetic structures and ultrarigid periodic frameworks. PMID:26973370

  16. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...

  17. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...

  18. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...

  19. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...

  20. 24 CFR 58.21 - Time periods.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Time periods. 58.21 Section 58.21...: Environmental Review Procedures § 58.21 Time periods. All time periods in this part shall be counted in calendar days. The first day of a time period begins at 12:01 a.m. local time on the day following...