Science.gov

Sample records for 36-150 huyshope avenue

  1. INTERIOR FOURTH FLOOR, SOUTH HALF, LOOKING SOUTH. NOTE MUSHROOM COLUMNS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR FOURTH FLOOR, SOUTH HALF, LOOKING SOUTH. NOTE MUSHROOM COLUMNS AND CEILING HAS WOODEN NAILERS. - Colt Fire Arms Company, North Armory, 36-150 Huyshope Avenue, 17-170 Van Dyke Avenue, 49 Vredendale Avenue, Hartford, Hartford County, CT

  2. INTERIOR SECOND FLOOR EAST END LOOKING WEST AT NORTH ROW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR SECOND FLOOR- EAST END LOOKING WEST AT NORTH ROW OF MUSHROOM COLUMNS. - Colt Fire Arms Company, South Armory Building, 36-150 Huyshope Avenue, 17-170 Van Dyke Avenue, 49 Vredendale Avenue, Hartford, Hartford County, CT

  3. Elevation of Warrington Avenue Bridge, southbound of Warrington Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Elevation of Warrington Avenue Bridge, southbound of Warrington Avenue - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  4. VIEW OF PIEDMONT AVENUE BETWEEN CHANNING WAY AND DURANT AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE BETWEEN CHANNING WAY AND DURANT AVENUE. 2325 PIEDMONT (MRS. F.W. FISH HOUSE DESIGNED BY CHARLES S. KAISER, 1910. SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  5. VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT AVENUE AT 2234 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT AVENUE AT 2234 PIEDMONT (DR. B.P. WALL HOUSE BY WILLIAM C. HAYS, 1909.) WEST SIDE OF THE STREET LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, June 29, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  6. Kids Working on Paulista Avenue

    ERIC Educational Resources Information Center

    Huggins, Martha K.; Rodrigues, Sandra

    2004-01-01

    Six weeks of field research on 14 poor youth who sell services or products on the opulent Paulista Avenue in Sao Paulo, Brazil, explored their work, play, aspirations and childhood outcomes. Comparing the 12 younger children to the two older youth workers who supervised them and to the few Brazilian longitudinal accounts of street youth, the…

  7. View of the Warrington Avenue Bridge portal, inbound from Pittsburgh ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the Warrington Avenue Bridge portal, inbound from Pittsburgh - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  8. View of the Warrington Avenue Bridge portal, outbound from Pittsburgh ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of the Warrington Avenue Bridge portal, outbound from Pittsburgh - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  9. 26. 100 Second Avenue, North, detail of 'Silver Dollars' on ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    26. 100 Second Avenue, North, detail of 'Silver Dollars' on southeast side - Second Avenue North, Commercial District, Second Avenue North between Broadway & Church Streets, Nashville, Davidson County, TN

  10. 1. General view of Second Avenue from Church Street looking ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. General view of Second Avenue from Church Street looking toward Broadway - Second Avenue North, Commercial District, Second Avenue North between Broadway & Church Streets, Nashville, Davidson County, TN

  11. Elevation of Warrington Avenue Bridge and cut stone retaining wall ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Elevation of Warrington Avenue Bridge and cut stone retaining wall southbound on Warrington Avenue - Pittsburgh & Castle Shannon Railroad, Warrington Avenue Bridge, Overbrook Trolley Line, Crossing Warrington Avenue, Pittsburgh, Allegheny County, PA

  12. San Pablo Avenue Green Stormwater Spine

    EPA Pesticide Factsheets

    Information about the SFBWQP San Pablo Avenue Green Stormwater Spine Project project, part of an EPA competitive grant program to improve SF Bay water quality focused on restoring impaired waters and enhancing aquatic resources.

  13. Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  14. PIQUETTE AVENUE STREETSCAPE WITH STUDEBAKER CORPORATION IN FOREGROUND. 411 PIQUETTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PIQUETTE AVENUE STREETSCAPE WITH STUDEBAKER CORPORATION IN FOREGROUND. 411 PIQUETTE AVENUE IN CENTER, AND FORD PIQIETTE PLANT ON THE OTHER SIDE. (Duplicate color view of HAER MI-349-1) - 411 Piquette Avenue (Industrial), Detroit, MI

  15. 23. VIEW NORTHWEST ON VIRGINIA AVENUE AXIS SHOWING NEW JERSEY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. VIEW NORTHWEST ON VIRGINIA AVENUE AXIS SHOWING NEW JERSEY AVENUE OVERPASS AND WASHINGTON MONUMENT. TAKEN FROM UNDERNEATH THE SOUTHEAST/SOUTHWEST FREEWAY. - Virginia Avenue, Washington, District of Columbia, DC

  16. 22. VIEW SOUTHWEST ON VIRGINIA AVENUE AXIS SHOWING SOUTH SIDE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. VIEW SOUTHWEST ON VIRGINIA AVENUE AXIS SHOWING SOUTH SIDE OF GARFIELD PARK, NARROW ROADWAY, RAILROAD TRACKS ENTERING THE TUNNEL, AND THE SOUTHEAST/SOUTHWEST FREEWAY. TAKEN FROM THE NEW JERSEY AVENUE OVERPASS. - Virginia Avenue, Washington, District of Columbia, DC

  17. Detail of southeast corner and pipes, shown along California Avenue; ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail of southeast corner and pipes, shown along California Avenue; camera facing north. - Mare Island Naval Shipyard, Central Power Plant, California Avenue, norhtwest corner of California Avenue & Seventh Street, Vallejo, Solano County, CA

  18. Contextual view of building 733 along Cedar Avenue; camera facing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 733 along Cedar Avenue; camera facing southwest. - Mare Island Naval Shipyard, WAVES Officers Quarters, Cedar Avenue, west side between Tisdale Avenue & Eighth Street, Vallejo, Solano County, CA

  19. 23. General view of Second Avenue from Broadway looking toward ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. General view of Second Avenue from Broadway looking toward Church Street HABS TENN 19-NASH, 14-2 - Second Avenue North, Commercial District, Second Avenue North between Broadway & Church Streets, Nashville, Davidson County, TN

  20. Contextual view looking down California Avenue, showing south and east ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view looking down California Avenue, showing south and east elevations; camera facing northwest. - Mare Island Naval Shipyard, Central Power Plant, California Avenue, norhtwest corner of California Avenue & Seventh Street, Vallejo, Solano County, CA

  1. Contextual view looking down railroad avenue with building 680 at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view looking down railroad avenue with building 680 at left and building 390 at right; camera facing south. - Mare Island Naval Shipyard, Machine Shop, California Avenue, southwest corner of California Avenue & Thirteenth Street, Vallejo, Solano County, CA

  2. 1. LOOKING EAST FROM 127125 JACKSON AVENUE (INDUSTRIAL COLLOIDS AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. LOOKING EAST FROM 127-125 JACKSON AVENUE (INDUSTRIAL COLLOIDS AND CHEMICALS, INC.) TO SULLIVAN'S SALOON (in background, with domed roof) - Jackson Avenue Warehouse District, 101-131 & 120-122 Jackson Avenue, Knoxville, Knox County, TN

  3. Contextual view of building 47 looking across Walnut Avenue, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 47 looking across Walnut Avenue, showing south elevation; camera facing northwest. - Mare Island Naval Shipyard, Old Administrative Offices, Eighth Street, north side between Railroad Avenue & Walnut Avenue, Vallejo, Solano County, CA

  4. Contextual view of building 253 looking down Walnut Avenue, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 253 looking down Walnut Avenue, showing south elevation at right; camera facing north. - Mare Island Naval Shipyard, Supply Building, Walnut Avenue, southeast corner of Walnut Avenue & Fifth Street, Vallejo, Solano County, CA

  5. Contextual view of building 47 looking across Walnut Avenue, with ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 47 looking across Walnut Avenue, with building 521 in foreground; camera facing northeast. - Mare Island Naval Shipyard, Old Administrative Offices, Eighth Street, north side between Railroad Avenue & Walnut Avenue, Vallejo, Solano County, CA

  6. FACILITY 858, PORTION OF NORTHEAST SIDE (APRON AVENUE SIDE), SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FACILITY 858, PORTION OF NORTHEAST SIDE (APRON AVENUE SIDE), SHOWING CHEVRON DESIGN OVER FORMER PASSAGEWAY, OBLIQUE VIEW FACING WEST. - Schofield Barracks Military Reservation, Quadrangle K Barracks Type, Between Wilson Street & Capron Avenue near Williston Avenue, Wahiawa, Honolulu County, HI

  7. View southwest toward Eldred Avenue from within Friend's Burial Ground, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View southwest toward Eldred Avenue from within Friend's Burial Ground, Benjamin Carr Farm in distance through the trees - Friends' Burial Ground, Eldred & Beacon Avenues, Jamestown, Newport County, RI

  8. ORNAMENTAL IRON FENCING ALONG FREDERICK AVENUE, FROM NORTHWEST CORNER OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ORNAMENTAL IRON FENCING ALONG FREDERICK AVENUE, FROM NORTHWEST CORNER OF CEMETERY, SHOWING SECTION A. VIEW TO SOUTHEAST. - Loudon Park National Cemetery, 3445 Frederick Avenue, Baltimore, Independent City, MD

  9. Microscopy Opening Up New Cancer Discovery Avenues

    Cancer.gov

    Today’s high-powered microscopes are allowing researchers to study the fine details of individual cells and to peer into cells, opening up new avenues of discovery about the inner workings of cells, including the events that can cause healthy cells to tra

  10. 23. Surrender interview site, showing Pemberton Avenue concrete slab road ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Surrender interview site, showing Pemberton Avenue concrete slab road type with gutter (asphalt construction typical on Union and Confederate Avenues), view to the sw. - Vicksburg National Military Park Roads & Bridges, Vicksburg, Warren County, MS

  11. EXTERIOR VIEW, LOOKING SOUTH, NEW AVENUE WITH A FORMER TCIUS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EXTERIOR VIEW, LOOKING SOUTH, NEW AVENUE WITH A FORMER TCI-US STEEL "DOUBLE THREE ROOM" COMPANY HOUSE BUILT FOR BLACK ORE MINERS AND THEIR FAMILIES DURING WORLD WAR I - New Village Worker Houses, New Avenue, Bessemer, Jefferson County, AL

  12. EXTERIOR VIEW, LOOKING SOUTH, NEW AVENUE WITH A FORMER TCIUS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    EXTERIOR VIEW, LOOKING SOUTH, NEW AVENUE WITH A FORMER TCI-US STEEL 'DOUBLE THREE ROOM' COMPANY HOUSE BUILT FOR BLACK ORE MINERS AND THEIR FAMILIES DURING WORLD WAR I. - New Village Worker Houses, New Avenue, Bessemer, Jefferson County, AL

  13. Close view of the south facade on Constitution Avenue to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close view of the south facade on Constitution Avenue to show main entrance - United States Department of Justice, Constitution Avenue between Ninth & Tenth Streets, Northwest, Washington, District of Columbia, DC

  14. Close view of the Constitution Avenue elevation to show arched ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Close view of the Constitution Avenue elevation to show arched gateways and pedimented pavilion ("Commerce and Communication" sculpted pediment) - Interstate Commerce Commission, Constitution Avenue between Twelfth and Fourteenth streets, Washington, District of Columbia, DC

  15. "BURBANK FARM" SHOWING BANK CUT CREATED WHEN BODEGA AVENUE ROADBED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    "BURBANK FARM" SHOWING BANK CUT CREATED WHEN BODEGA AVENUE ROADBED WAS LOWERED. WPA STONE RETAINING WALL AT BASE OF CUT. LOOKING SOUTHWEST. - Gold Ridge Farm, 7777 Bodega Avenue, Sebastopol, Sonoma County, CA

  16. 1. ARROYO SECO PARKWAY SOUTHBOUND LANES AND PASADENA AVENUE BRIDGE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. ARROYO SECO PARKWAY SOUTHBOUND LANES AND PASADENA AVENUE BRIDGE. RAILROAD BRIDGE IN DISTANCE. LOOKING 238°WSW. - Arroyo Seco Parkway, Pasadena Avenue Bridge, Milepost 26.48, Los Angeles, Los Angeles County, CA

  17. 2. PASADENA AVENUE BRIDGE CROSSING ARROYO SECO PARKWAY. SEEN FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. PASADENA AVENUE BRIDGE CROSSING ARROYO SECO PARKWAY. SEEN FROM CARLOTA BOULEVARD. LOOKING 218°SW. - Arroyo Seco Parkway, Pasadena Avenue Bridge, Milepost 26.48, Los Angeles, Los Angeles County, CA

  18. 1. ARROYO SECO PARKWAY AND AVENUE 60 BRIDGE. NOTE CONCRETE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. ARROYO SECO PARKWAY AND AVENUE 60 BRIDGE. NOTE CONCRETE EMBANKMENT OF ARROYO SECO CHANNEL ON RIGHT. LOOKING 12°N. - Arroyo Seco Parkway, Avenue 60 Bridge, Milepost 28.76, Los Angeles, Los Angeles County, CA

  19. 5. ARROYO SECO PARKWAY SEEN FROM AVENUE 60 BRIDGE. NOTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. ARROYO SECO PARKWAY SEEN FROM AVENUE 60 BRIDGE. NOTE ACCESS ROAD AT CENTER REAR AND REFUGE LANE AT LEFT FOREGROUND. LOOKING 212"SSW - Arroyo Seco Parkway, Avenue 60 Bridge, Milepost 28.76, Los Angeles, Los Angeles County, CA

  20. 2. AVENUE 43 ACCESS ROAD AND BRIDGE ACROSS ARROYO SECO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. AVENUE 43 ACCESS ROAD AND BRIDGE ACROSS ARROYO SECO WITH NORTHBOUND PARKWAY LANES IN FOREGROUND. LOOKING 76°E. - Arroyo Seco Parkway, Avenue 43 Bridge, Milepost 27.12, Los Angeles, Los Angeles County, CA

  1. 72. 451 MADISON AVENUE, GRAND STAIR, ZODIAC CLOCK WITH DECORATIVE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    72. 451 MADISON AVENUE, GRAND STAIR, ZODIAC CLOCK WITH DECORATIVE CARVING BY STANFORD WHITE AND AUGUSTUS SAINT-GAUDENS - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  2. Detail view of lancetarched, concrete pedestrian railing Union Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Detail view of lancet-arched, concrete pedestrian railing - Union Avenue Viaduct, Spanning between Southeast Harrison & Southeast Ivon Streets on Union Avenue (Old Highway 99 East), Portland, Multnomah County, OR

  3. 88. 451 MADISON AVENUE, LIBRARY, SOUTH WALL, WEST CENTRAL SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    88. 451 MADISON AVENUE, LIBRARY, SOUTH WALL, WEST CENTRAL SECTION SHOWING WINDOW AND RADIATOR (Pair with NY-5635-89) - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  4. 13. Tenth Avenue grade separation: south side with elevator no. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Tenth Avenue grade separation: south side with elevator no. 2 and track shed to left, facing north-northwest - Washburn Crosby Company Elevators No. 2 & 3, 900 & 1000 Second Avenue, South, Minneapolis, Hennepin County, MN

  5. 3. AERIAL VIEW OF FLORIDA AVENUE AND GALLAUDET UNIVERSITY, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. AERIAL VIEW OF FLORIDA AVENUE AND GALLAUDET UNIVERSITY, LOOKING NORTHEAST FROM OVER NINTH AND K STREETS, NE. (Photograph enlarged from 4x5 negative.) - Florida Avenue, Washington, District of Columbia, DC

  6. View of east elevation along California Avenue; camera facing west. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of east elevation along California Avenue; camera facing west. - Mare Island Naval Shipyard, Rubber Shop, California Avenue, west side across from Dry Dock 1 near Ninth Street, Vallejo, Solano County, CA

  7. 1. View southeast from Eldred Avenue toward stone wall at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View southeast from Eldred Avenue toward stone wall at corner of Benjamin Carr Farm. Wall moved to current location in 1941-1942. - Benjamin Carr Farm, Route 138 (Eldred Avenue) & Helm Street, Jamestown, Newport County, RI

  8. 46. Exterior view at the corner of Seventh Avenue and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    46. Exterior view at the corner of Seventh Avenue and Olive Way, looking NE. Opening night film, 'The Broadway Melody,' displayed on the canopy marquee. - Fox Theater, Seventh Avenue & Olive Way, Seattle, King County, WA

  9. CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE, SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE, SHOWING WEST ELEVATION. CAMERA FACING SOUTH - Mare Island Naval Shipyard, Bachelor Enlisted Quarters & Offices, Walnut Avenue, east side between D Street & C Street, Vallejo, Solano County, CA

  10. CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE; CAMERA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CONTEXTUAL VIEW OF BUILDING 459 LOOKING ALONG WALNUT AVENUE; CAMERA FACING SOUTH - Mare Island Naval Shipyard, Bachelor Enlisted Quarters & Offices, Walnut Avenue, east side between D Street & C Street, Vallejo, Solano County, CA

  11. 6. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, LOOKING NORTHWEST FROM THIRD AVENUE - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  12. 3. AERIAL VIEW LOOKING NORTHWEST ON THE VIRGINIA AVENUE AXIS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. AERIAL VIEW LOOKING NORTHWEST ON THE VIRGINIA AVENUE AXIS FROM THE ANACOSTIA RIVER TO THE WASHINGTON MONUMENT. (Photograph enlarged from 4x5 negative.) - Virginia Avenue, Washington, District of Columbia, DC

  13. View along Cavalry Avenue, with building 210 in left foreground ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View along Cavalry Avenue, with building 210 in left foreground and left to right, buildings 212 through 222. View to east. - Fort David A. Russell, Randall Avenue west of First Street, Cheyenne, Laramie County, WY

  14. View across Cavalry Avenue, with fire station (building 285) in ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View across Cavalry Avenue, with fire station (building 285) in left foreground and enlisted personnel barracks (building 222) in background. View to north. - Fort David A. Russell, Randall Avenue west of First Street, Cheyenne, Laramie County, WY

  15. 60. 451 MADISON AVENUE, DRAWING ROOM, NORTH WALL, WEST MURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    60. 451 MADISON AVENUE, DRAWING ROOM, NORTH WALL, WEST MURAL PAINTING SHOWING A WOMAN (See NY-5635-54 for original location) - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  16. Contextual view of building 505 Cedar avenue, showing south and ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 505 Cedar avenue, showing south and east elevations; camera facing northwest. - Mare Island Naval Shipyard, Defense Electronics Equipment Operating Center, I Street, terminus west of Cedar Avenue, Vallejo, Solano County, CA

  17. Interior showing both 425 and 427 North Miami Avenue, view ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Interior showing both 425 and 427 North Miami Avenue, view looking west, pressed tin ceiling in 425 North Miami is visible on the left - Chaille Commercial Building, 425-429 North Miami Avenue, Miami, Miami-Dade County, FL

  18. LOOKING ALONG HALE ALII AVENUE TOWARD SHIPYARD AREA. FACILITIES 1040 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING ALONG HALE ALII AVENUE TOWARD SHIPYARD AREA. FACILITIES 1040 AND 1041 (QUARTERS 1 AND J) AT LEFT. VIEW FACING SOUTHWEST. - U.S. Naval Base, Pearl Harbor, Naval Housing Area Hale Alii, Hale Alii Avenue, Eighth Street, & Avenue D, Pearl City, Honolulu County, HI

  19. 22. View of east side of South Gaskin Avenue at ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. View of east side of South Gaskin Avenue at the intersection with East Ashley Street, facing east. - Gaskin Avenue Neighborhood, Bounded by Dart Street to east, CSX Railroad to south, Pearl & Madison Avenues to west, & Wilson & Gordon Streets to north, Douglas, Coffee County, GA

  20. 23. View of west side of South Coweta Avenue south ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. View of west side of South Coweta Avenue south of East Ward Street, facing west. - Gaskin Avenue Neighborhood, Bounded by Dart Street to east, CSX Railroad to south, Pearl & Madison Avenues to west, & Wilson & Gordon Streets to north, Douglas, Coffee County, GA

  1. 24. View of west side of South Coweta Avenue south ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    24. View of west side of South Coweta Avenue south of East Ward Street, facing northwest. - Gaskin Avenue Neighborhood, Bounded by Dart Street to east, CSX Railroad to south, Pearl & Madison Avenues to west, & Wilson & Gordon Streets to north, Douglas, Coffee County, GA

  2. 2. AERIAL VIEW, LOOKING WEST, ALONG FIRST AVENUE NORTH, WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. AERIAL VIEW, LOOKING WEST, ALONG FIRST AVENUE NORTH, WITH BROWN MARX BUILDING (BOTTOM CENTER TO RIGHT), EMPIRE BUILDING (CENTER TOP) WITH ITS TERRACOTTA-CLAD 20TH STREET AND FIRST AVENUE FACADES, AND JOHN HAND BUILDING - Heaviest Corner on Earth (Commercial), First Avenue, North & Twentieth (20th) Street, North, Birmingham, Jefferson County, AL

  3. Contextual view of building 65 looking across California Avenue showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 65 looking across California Avenue showing building 65 east elevation at left and buildings 99 and 99A at right; camera facing northwest. - Mare Island Naval Shipyard, Printing Plant, California Avenue, northwest corner of California Avenue & Eighth Street, Vallejo, Solano County, CA

  4. Contextual view of building 65 looking across California Avenue showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of building 65 looking across California Avenue showing building 65 east elevation at left and buildings 99 and 99A at right; camera facing southwest - Mare Island Naval Shipyard, Printing Plant, California Avenue, northwest corner of California Avenue & Eighth Street, Vallejo, Solano County, CA

  5. View of Hinkley Avenue from former intersection with Hoffman Boulevard. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue from former intersection with Hoffman Boulevard. Note reconstructed Easter Hill Buildings No. 2, 3, and 4 from left to right at rear. Looking north - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  6. View of Hinkley Avenue looking towards former intersection with Hoffman ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of Hinkley Avenue looking towards former intersection with Hoffman Boulevard. Note former building site of Building No. 1 at right rear. Looking southwest - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  7. Avenues for crowd science in Hydrology.

    NASA Astrophysics Data System (ADS)

    Koch, Julian; Stisen, Simon

    2016-04-01

    Crowd science describes research that is conducted with the participation of the general public (the crowd) and gives the opportunity to involve the crowd in research design, data collection and analysis. In various fields, scientists have already drawn on underused human resources to advance research at low cost, with high transparency and large acceptance of the public due to the bottom up structure and the participatory process. Within the hydrological sciences, crowd research has quite recently become more established in the form of crowd observatories to generate hydrological data on water quality, precipitation or river flow. These innovative observatories complement more traditional ways of monitoring hydrological data and strengthen a community-based environmental decision making. However, the full potential of crowd science lies in internet based participation of the crowd and it is not yet fully exploited in the field of Hydrology. New avenues that are not primarily based on the outsourcing of labor, but instead capitalize the full potential of human capabilities have to emerge. In multiple realms of solving complex problems, like image detection, optimization tasks, narrowing of possible solutions, humans still remain more effective than computer algorithms. The most successful online crowd science projects Foldit and Galaxy Zoo have proven that the collective of tens of thousands users could clearly outperform traditional computer based science approaches. Our study takes advantage of the well trained human perception to conduct a spatial sensitivity analysis of land-surface variables of a distributed hydrological model to identify the most sensitive spatial inputs. True spatial performance metrics, that quantitatively compare patterns, are not trivial to choose and their applicability is often not universal. On the other hand humans can quickly integrate spatial information at various scales and are therefore a trusted competence. We selected

  8. 12. LOOKING SOUTH ONTO PROPERTY FROM BODEGA AVENUE SHOWING HOUSING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. LOOKING SOUTH ONTO PROPERTY FROM BODEGA AVENUE SHOWING HOUSING DEVELOPMENT. 'BURBANK FARM' ON RIGHT. TALL TREE TO RIGHT OF STREET LIGHT IS EUCALYPTUS ON WEST OF COTTAGE WHICH IS PLANNED FOR REMOVAL. 13. 'BURBANK FARM' SHOWING BANK CUT CREATED WHEN BODEGA AVENUE ROADBED WAS LOWERED. WPA STONE RETAINING WALL AT BASE OF CUT. LOOKING SOUTHWEST. - Gold Ridge Farm, 7777 Bodega Avenue, Sebastopol, Sonoma County, CA

  9. Management engineering (building no. 4), looking west along Porter Avenue. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Management engineering (building no. 4), looking west along Porter Avenue. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Management Engineering, League Island, Philadelphia, Philadelphia County, PA

  10. View from Western Avenue looking northwest down curbside walkway. Building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View from Western Avenue looking northwest down curbside walkway. Building 15 in left foreground. Illustration of asymmetrical layout and forty-five degree angle of buildings to public street - Harbor Hills Housing Project, 26607 Western Avenue, Lomita, Los Angeles County, CA

  11. 4. View west of Eldred Avenue towards the Jamestown Bridge, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. View west of Eldred Avenue towards the Jamestown Bridge, Benjamin Carr Farm to the south (left), Friends' Burial Ground to the north (right) in the background with stone wall and Cedar Hill Cemetery to the north (right) in the foreground with white picket fence. (See also HABS No. RI-398) - Benjamin Carr Farm, Route 138 (Eldred Avenue) & Helm Street, Jamestown, Newport County, RI

  12. LOOKING WNW, CHEVROLET AVENUE BRIDGE CROSSING FLINT RIVER. BRIDGE CONNECTED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    LOOKING WNW, CHEVROLET AVENUE BRIDGE CROSSING FLINT RIVER. BRIDGE CONNECTED NORTH AND SOUTH PORTIONS OF FACTORY COMPLEX. DANIEL LUTEN DESIGNED THE BRIDGE, AND ILLINOIS BRIDGE COMPANY BUILT IT IN 1918. THE BRIDGE WAS THE SITE OF THE BATTLE OF RUNNING BULLS IN THE 1936-1937 GM SIT DOWN STRIKE. - Delphi Flint West, 300 Chevrolet Avenue, Flint, Genesee County, MI

  13. 2. VIEW NORTHWEST FROM NINTH AVENUE (Compare with HABS NO. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW NORTHWEST FROM NINTH AVENUE (Compare with HABS NO. WI-308-89, taken in 1943.) - Fort McCoy, Building No. T-1065, Northeast of Intersection of South Ninth Avenue & South "Y" Street, Block 10, Sparta, Monroe County, WI

  14. Looking west along Railroad Avenue toward the Fire House, visible ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking west along Railroad Avenue toward the Fire House, visible in the center distance, behind the left Sentry House. The historic Marine Barracks (Building 930) is also visible at the far left, and Building 1296 in the right distance - Mare Island Naval Shipyard, South Fire Station, Railroad Avenue near Eighteenth Street, Vallejo, Solano County, CA

  15. 6. VIEW FROM AVENUE 26 BRIDGE OF ARROYO SECO PARKWAY. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. VIEW FROM AVENUE 26 BRIDGE OF ARROYO SECO PARKWAY. NOTE CHANGE IN ELEVATION OF SOUTHBOUND LANES TO MEET GRADE FOR ELYSIAN PARK ROAD CUT. INTERSTATE I-5 IN CENTER REAR. LOOKING 232°SW. - Arroyo Seco Parkway, Avenue 26 Bridge, Milepost 25.91, Los Angeles, Los Angeles County, CA

  16. 3. VIEW OF ARROYO SECO PARKWAY FROM PASADENA AVENUE BRIDGE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW OF ARROYO SECO PARKWAY FROM PASADENA AVENUE BRIDGE. NOTE RETAINING WALL AT RIGHT. RAILROAD BRIDGE AT CENTER REAR. LOOKING 238°SW. - Arroyo Seco Parkway, Pasadena Avenue Bridge, Milepost 26.48, Los Angeles, Los Angeles County, CA

  17. 5. VIEW FROM AVENUE 26 BRIDGE OF ARROYO SECO CHANNEL. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW FROM AVENUE 26 BRIDGE OF ARROYO SECO CHANNEL. NOTE INTERSTATE I-5 OVERCROSSING AT CENTER REAR AND GRAND VIEW POINT IN ELYSIAN PARK AT CENTER DISTANCE. LOOKING 236°SW. - Arroyo Seco Parkway, Avenue 26 Bridge, Milepost 25.91, Los Angeles, Los Angeles County, CA

  18. 8. VIEW OF ARROYO SECO PARKWAY FROM AVENUE 26 BRIDGE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW OF ARROYO SECO PARKWAY FROM AVENUE 26 BRIDGE. NOTE ARROYO SECO CHANNEL TO RIGHT OF FREEWAY. RAILWAY BRIDGE IS SEEN IN DISTANCE. LOOKING NE. - Arroyo Seco Parkway, Avenue 26 Bridge, Milepost 25.91, Los Angeles, Los Angeles County, CA

  19. VIEW FROM CENTER OF ELM AVENUE, LOOKING WEST INTO SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW FROM CENTER OF ELM AVENUE, LOOKING WEST INTO SECTION L. AT LEFT STANDS THE PONDEROUS MCDANIEL MAUSOLEUM, WHICH SHOWS THE INFLUENCE OF FRANK FURNESS ON H. Q. FRENCH’S 1887 DESIGN - Woodlands Cemetery, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

  20. 1. View along centerline of Palm Avenue, showing 212 Palm ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. View along centerline of Palm Avenue, showing 212 Palm (right center) in setting; building at extreme right center is 208 Palm (HABS-CA-2211); view to northeast. - Albert Hayman Cottage, 212 Palm Avenue, Santa Barbara, Santa Barbara County, CA

  1. 7. ARROYO SECO PARKWAY SEEN FROM AVENUE 60 BRIDGE. NOTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. ARROYO SECO PARKWAY SEEN FROM AVENUE 60 BRIDGE. NOTE ACCESS ROAD FOR NORTHBOUND LANES AT RIGHT REAR; AT&SF RAILROAD BRIDGE AT CENTER DISTANCE; PARK LANDS AT LEFT REAR. LOOKING 2°N. - Arroyo Seco Parkway, Avenue 60 Bridge, Milepost 28.76, Los Angeles, Los Angeles County, CA

  2. VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM NE CORNER LOOKING SW. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  3. VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY VIEW OF 2401 PIEDMONT, ALPHA EPSILON PHI HOUSE BY RATCLIFF & RATCLIFF, 1958. SEEN FROM NW CORNER LOOKING SE. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  4. VIEW OF PIEDMONT AVENUE AND MEDIAN. REPLICATING WERNER HEGEMANN PHOTO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AND MEDIAN. REPLICATING WERNER HEGEMANN PHOTO TAKEN CIRCA 1909 SEEN FROM TRAFFIC CIRCLE AT CHANNING WAY LOOKING NW. Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  5. 3. VIEW OF CENTRAL AVENUE LOOKING WEST FROM JUST EAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW OF CENTRAL AVENUE LOOKING WEST FROM JUST EAST OF THE INTERSECTION OF CENTRAL AVENUE AND THE EAST PERIMETER ROAD. THE ROCKY FLATS PLANT IS ABOUT 16 MILES NORTHWEST OF DENVER ON A PLATEAU AT THE EASTERN EDGE OF THE FRONT RANGE OF THE ROCKY MOUNTAINS. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  6. 4. Passaic River looking northwest from Ackerman Avenue bridge; Dundee ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Passaic River looking northwest from Ackerman Avenue bridge; Dundee Textile Company Mill at left - Dundee Canal Industrial Historic District, Beginning at George Street in Passaic & extending north along Dundee Canal approximately 1.2 miles to Canal headgates opposite East Clifton Avenue in Clifton, Passaic, Passaic County, NJ

  7. View of southwest elevation of Building No. 42. Foothill Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of southwest elevation of Building No. 42. Foothill Avenue in foreground, seen from yard of Building No. 41, Building No. 44 at rear. Looking northeast - Easter Hill Village, Building No. 42, Northwest corner of Foothill Avenue & South Twenty-eighth Street, Richmond, Contra Costa County, CA

  8. VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY. SEEN FROM ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE NORTH OF BANCROFT WAY. SEEN FROM WEST SIDE OF PIEDMONT LOOKING NORTH. NOTE OAK GROVE AND UNIVERSITY OF CALIFORNIA FOOTBALL STADIUM AT RIGHT REAR. NOTE STAIRCASE IN MEDIAN. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  9. 59. 451 MADISON AVENUE, DRAWING ROOM, NORTH WALL, CENTRAL MURAL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    59. 451 MADISON AVENUE, DRAWING ROOM, NORTH WALL, CENTRAL MURAL PAINTING SHOWING WOMAN ON A SWING (See NY-5635-54 for original location) - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  10. DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DETAIL VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM EAST SIDE OF CIRCLE LOOKING NORTH AT 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  11. VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE TRAFFIC CIRCLE AT INTERSECTION OF CHANNING WAY. SEEN FROM SW CORNER TOWARDS 2395 PIEDMONT, SIGMA PI HOUSE BY FREDERICK H. REIMERS, 1928. LOOKING NORTH. Photograph by Brian Grogan, July 8, 2007 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  12. 1. 319 EAST COMMERCIAL AVENUE IS THE SINGLE STORY BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 319 EAST COMMERCIAL AVENUE IS THE SINGLE STORY BUILDING IN THE CENTER OF THE PHOTOGRAPH. IT IS DISTINGUISHED BY ITS CAST METAL FACADE WITH WOODEN INLAY, AND THE PRESSED METAL CORNICE AT THE PARAPET WALL - Anaconda Historic District, 319 East Commercial Avenue, Anaconda, Deer Lodge County, MT

  13. VIEW OF PIEDMONT AVENUE AT INTERSECTION OF HASTE STREET, CHATEAU ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT INTERSECTION OF HASTE STREET, CHATEAU APARTMENTS BY CLARENCE CASEBOLT DAKIN, 1929 AT 2747 HASTE ON WEST SIDE OF PIEDMONT. LOOKING NORTH. Photograph by Fredrica Drotos and Michael Kelly, July 8, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  14. 23. East Tremont Avenue Bridge crossing NEC. West Farms, Bronx ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. East Tremont Avenue Bridge crossing NEC. West Farms, Bronx Co., NY. Sec. 4207, MP 12.44. - Northeast Railroad Corridor, Amtrak Route between New Jersey/New York & New York/Connecticut State Lines, New York County, NY

  15. 37. Webster Avenue Bridge. New Rochelle, Westchester Co., NY. Sec. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    37. Webster Avenue Bridge. New Rochelle, Westchester Co., NY. Sec. 4207, MP 19.12. - Northeast Railroad Corridor, Amtrak Route between New Jersey/New York & New York/Connecticut State Lines, New York County, NY

  16. 36. Webster Avenue Bridge. New Rochelle, Westchester Co., NY. Sec. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    36. Webster Avenue Bridge. New Rochelle, Westchester Co., NY. Sec. 4207, MP 19.12. - Northeast Railroad Corridor, Amtrak Route between New Jersey/New York & New York/Connecticut State Lines, New York County, NY

  17. VIEW SOUTHSOUTH CLINTON AVENUE BUILDING 35 CLINTON ST. WIRE MILL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW SOUTH-SOUTH CLINTON AVENUE BUILDING 35 CLINTON ST. WIRE MILL (1899) - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  18. 7. RARITAN AVENUE BRIDGE. NEW BRUNSWICK, MIDDLESEX CO., NJ. Sec. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. RARITAN AVENUE BRIDGE. NEW BRUNSWICK, MIDDLESEX CO., NJ. Sec. 1401, MP 30.92. - Northeast Railroad Corridor, Amtrak Route between Pennsylvania/New Jersey & New Jersey/New York State Lines, Newark, Essex County, NJ

  19. 23. Haynes Avenue Bridge. Newark, Essex Co., NJ. Sec. 1401, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    23. Haynes Avenue Bridge. Newark, Essex Co., NJ. Sec. 1401, MP 11.39. - Northeast Railroad Corridor, Amtrak Route between Pennsylvania/New Jersey & New Jersey/New York State Lines, Newark, Essex County, NJ

  20. 5. NEW BRUNSWICK STATION AND EASTON AVENUE BRIDGE NEW BRUNSWICK, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. NEW BRUNSWICK STATION AND EASTON AVENUE BRIDGE NEW BRUNSWICK, MIDDLESEX CO., NJ. Sec. 1401, MP 31.36. - Northeast Railroad Corridor, Amtrak Route between Pennsylvania/New Jersey & New Jersey/New York State Lines, Newark, Essex County, NJ

  1. 16. Rahway Avenue Bridge. Elizabeth, Union Co., NJ. Sec. 1401, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. Rahway Avenue Bridge. Elizabeth, Union Co., NJ. Sec. 1401, MP 14.49. - Northeast Railroad Corridor, Amtrak Route between Pennsylvania/New Jersey & New Jersey/New York State Lines, Newark, Essex County, NJ

  2. 4. NEW BRUNSWICK STATION AND EASTON AVENUE BRIDGE. NEW BRUNSWICK, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. NEW BRUNSWICK STATION AND EASTON AVENUE BRIDGE. NEW BRUNSWICK, MIDDLESEX CO., NJ. Sec. 1401, MP 31.36. - Northeast Railroad Corridor, Amtrak Route between Pennsylvania/New Jersey & New Jersey/New York State Lines, Newark, Essex County, NJ

  3. 6. RARITAN AVENUE BRIDGE. NEW BRUNSWICK, MIDDLESEX CO., NJ. Sec. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. RARITAN AVENUE BRIDGE. NEW BRUNSWICK, MIDDLESEX CO., NJ. Sec. 1401, MP 30.92 - Northeast Railroad Corridor, Amtrak Route between Pennsylvania/New Jersey & New Jersey/New York State Lines, Newark, Essex County, NJ

  4. 22. Haynes Avenue Bridge. Newark, Essex Co., NJ. Sec. 1401, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. Haynes Avenue Bridge. Newark, Essex Co., NJ. Sec. 1401, MP 11.39. - Northeast Railroad Corridor, Amtrak Route between Pennsylvania/New Jersey & New Jersey/New York State Lines, Newark, Essex County, NJ

  5. 10. Milton Avenue Bridge. Rahway, Union Co., NJ. Sec. 1401, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Milton Avenue Bridge. Rahway, Union Co., NJ. Sec. 1401, MP 19.41. - Northeast Railroad Corridor, Amtrak Route between Pennsylvania/New Jersey & New Jersey/New York State Lines, Newark, Essex County, NJ

  6. 2. SOUTH CLINTON AVENUE BRIDGE. TRENTON, MERCER CO., NJ. Sec. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. SOUTH CLINTON AVENUE BRIDGE. TRENTON, MERCER CO., NJ. Sec. 1401, MP 56.77. - Northeast Railroad Corridor, Amtrak Route between Pennsylvania/New Jersey & New Jersey/New York State Lines, Newark, Essex County, NJ

  7. Looking east along Porter Avenue, management engineering in foreground; supply ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Looking east along Porter Avenue, management engineering in foreground; supply department storehouse (building no. 5) (Haer no. PA-387-1) to left. - Naval Base Philadelphia-Philadelphia Naval Shipyard, Management Engineering, League Island, Philadelphia, Philadelphia County, PA

  8. 31. AERIAL VIEW OF ARROYO SECO PARKWAY. AVENUE 60 BRIDGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    31. AERIAL VIEW OF ARROYO SECO PARKWAY. AVENUE 60 BRIDGE AT CENTER. NOTE PEDESTRIAN FOOTBRIDGE OVER ARROYO SECO AT LOWER RIGHT OF CENTER. LOOKING NE. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  9. 11. VIEW OF ARROYO SECO CHANNEL SEEN FROM AVENUE 14 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    11. VIEW OF ARROYO SECO CHANNEL SEEN FROM AVENUE 14 BRIDGE. SAN FERNANDO ROAD BRIDGE AT CENTER. LOOKING 25° NNE. - Arroyo Seco Parkway, Figueroa Street Viaduct, Spanning Los Angeles River, Los Angeles, Los Angeles County, CA

  10. 9. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    9. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, LOOKING SOUTHEAST FROM WAREHOUSE, SHOWING TRACK MATERIAL STORED IN YARD - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  11. 71. 129 HILLSIDE AVENUE, SUBSTATION, VIEW OF MOTORWOUND SPRING TRIGGERED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    71. 129 HILLSIDE AVENUE, SUBSTATION, VIEW OF MOTOR-WOUND SPRING- TRIGGERED A. C. OIL-CIRCUIT BREAKERS ON MAIN FLOOR UNDER GALLERY. MOTOR SITES ATOP THE BRICK COMPARTMENT. - Interborough Rapid Transit Subway (Original Line), New York County, NY

  12. 27. Yards north of Branch Avenue Bridge. Providence, Providence Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    27. Yards north of Branch Avenue Bridge. Providence, Providence Co., RI. Sec. 4116, mp 186.25. - Northeast Railroad Corridor, Amtrak route between CT & MA state lines, Providence, Providence County, RI

  13. 28. Yards north of Branch Avenue Bridge. Providence, Providence Co., ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    28. Yards north of Branch Avenue Bridge. Providence, Providence Co., RI. Sec. 4116, mp 186.25. - Northeast Railroad Corridor, Amtrak route between CT & MA state lines, Providence, Providence County, RI

  14. Contextual view of Fyffe Avenue. Police station (building no. 17) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue. Police station (building no. 17) is shown in foreground. Camera facing northwest. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  15. View of steel warehouses at Gilmore Avenue (building 710 second ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of steel warehouses at Gilmore Avenue (building 710 second in on left); camera facing east. - Naval Supply Annex Stockton, Steel Warehouse Type, Between James & Humphreys Drives south of Embarcadero, Stockton, San Joaquin County, CA

  16. NORTH GATE AT 11TH AVENUE (490 NORTH & 900 EAST), ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    NORTH GATE AT 11TH AVENUE (490 NORTH & 900 EAST), SALT LAKE CITY, UT. VIEW LOOKING SOUTH AT CEMETERY'S NORTH GATE (WPA PROJECT, 1938-1941). - Salt Lake City Cemetery, 200 N Street, Salt Lake City, Salt Lake County, UT

  17. B & P Tunnel east portal & North Avenue Bridge. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    B & P Tunnel east portal & North Avenue Bridge. Baltimore, Baltimore City, MD. Sec. 1201, MP 96.00. - Northeast Railroad Corridor, Amtrak route between District of Columbia/Maryland state line & Maryland/Delaware state line, Baltimore, Independent City, MD

  18. 20. AVENUE OF THE GIANTS, OLD HIGHWAY 101, ROAD VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    20. AVENUE OF THE GIANTS, OLD HIGHWAY 101, ROAD VIEW .5 MILE NORTH OF MIRANDA. HUMBOLDT COUNTY, CALIFORNIA. LOOKING NW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  19. 69. AVENUE OF THE GIANTS, OLD HIGHWAY 101, ROAD VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    69. AVENUE OF THE GIANTS, OLD HIGHWAY 101, ROAD VIEW 1.5 MILES NORTH OF MIRANDA. HUMBOLDT COUNTY, CALIFORNIA. LOOKING N. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  20. 68. AVENUE OF THE GIANTS, OLD HIGHWAY 101, ROAD VIEW ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    68. AVENUE OF THE GIANTS, OLD HIGHWAY 101, ROAD VIEW .5 MILE NORTH OF MIRANDA. HUMBOLDT COUNTY, CALIFORNIA. LOOKING NW. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  1. 4. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, SHOWING DETAIL OF TRACK WORK AND OVERHEAD WIRING - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  2. 1. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, LOOKING SOUTHWEST - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  3. 5. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, LOOKING SOUTH ALONG EAST SIDE OF CAR BARN TOWARD POWER SUBSTATION - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  4. 8. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, LOOKING NORTHEAST ADJACENT TO WAREHOUSE TOWARD CAR BARN - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  5. 3. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, LOOKING NORTHEAST - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  6. 2. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, LOOKING WEST - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  7. VIEW ALONG OHIO AVENUE, LOOKING TOWARD 1905 BAND BARRACKS (BUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW ALONG OHIO AVENUE, LOOKING TOWARD 1905 BAND BARRACKS (BUILDING 61 O)CENTER AND FORAGE HOUSE (BUILDING 476)LEFT. VIEW TO NORTHWEST - Plattsburgh Air Force Base, U.S. Route 9, Plattsburgh, Clinton County, NY

  8. 32. AERIAL VIEW OF ARROYO SECO PARKWAY AT AVENUE 60. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    32. AERIAL VIEW OF ARROYO SECO PARKWAY AT AVENUE 60. AT&SF RAILROAD BRIDGE AT BACK. NOTE AVENUE 60 ACCESS ROAD AND BRIDGE OVER ARROYO SECO. DEBS PARK HILL AT CENTER IS LOCATION OF CAMERA POSITION FOR PHOTOGRAPHS CA-265-13, CA265-14, AND CA-265-V-4. LOOKING NE. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  9. 97. 451 MADISON AVENUE, LIBRARY CEILING DESIGNED BY GEORGE BRECK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    97. 451 MADISON AVENUE, LIBRARY CEILING DESIGNED BY GEORGE BRECK (The photographs are arranged sequentially with NY-5635-91 in the southwest corner proceeding eastward to NY-5635-98 in the southeast corner; the sequence begins again with NY-5635-99 in the northwest corner and ends with NY-5635-106 in the northeast corner; all photographs overlap) - Villard Houses, 451-457 Madison Avenue & 24 East Fifty-first Street, New York County, NY

  10. GENERAL VIEW, MAIN ENTRANCE GATES, LOOKING SOUTH ACROSS WOODLANDS AVENUE. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GENERAL VIEW, MAIN ENTRANCE GATES, LOOKING SOUTH ACROSS WOODLANDS AVENUE. IN 1933, A CITY OF PHILADELPHIA LAND CONDEMNATION REQUIRED THE DEMOLITION OF AN EXISTING GATEWAY COMPLETED IN 1857 ON PLANS BY JOHN MCARTHUR, JR. PAUL CRET DESIGNED THE NEW GATES IN 1936. THEY WERE COMPLETED THE FOLLOWING YEAR AND MOVED TO THEIR PRESENT LOCATION IN 1948 AFTER ANOTHER CITY LAND CONDEMNATION. - Woodlands Cemetery, 4000 Woodlands Avenue, Philadelphia, Philadelphia County, PA

  11. VIEW OF PIEDMONT AVENUE AT BANCROFT WAY SEEN FROM WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF PIEDMONT AVENUE AT BANCROFT WAY SEEN FROM WEST SIDE OF PIEDMONT LOOKING SOUTH WITH BRICK WALL RUNNING NORTH TO SOUTH IN FRONT OF 2302 PIEDMONT (F. WOODWARD HOUSE BY EDWARD B. SEELY, 1909). Photograph by Fredrica Drotos and Michael Kelly, July 9, 2006 - Piedmont Way & the Berkeley Property Tract, East of College Avenue between Dwight Way & U.C. Memorial Stadium, Berkeley, Alameda County, CA

  12. 22. View looking north on Central Avenue from Washington Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. View looking north on Central Avenue from Washington Street. The Stroud Building (with awnings on the second story) is located on the east (right) side of the street near the center of the block. The original Adams Hotel is seen at the right rear of the photograph Circa 1901-1910. Credit ADLAPR. - Stroud Building, 31-33 North Central Avenue, Phoenix, Maricopa County, AZ

  13. Avenues of Influence Cross-Cultural Implications (Briefing Charts)

    DTIC Science & Technology

    2012-11-01

    cultural dimensions assessed typically evidence considerable overlap within cultures (Fiske, Kitayama, Markus, & Nisbett, 1998); and this overlap can mask...AFRL-RH-WP-TR-2013-0112               AVENUES OF INFLUENCE: CROSS- CULTURAL IMPLICATIONS (BRIEFING CHARTS)   Janet Sutton, PhD. Human...NUMBER N/A Avenues of Influence: Cross- Cultural Implications (Briefing Charts) 5b. GRANT NUMBER   5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d

  14. 4. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. VIEW LOOKING WEST DOWN CENTRAL AVENUE AT THE INTERSECTION WITH SEVENTH STREET. THE PLANT HAS MOST OF THE AMENITIES OF A SMALL TOWN - WATER SUPPLY, WASTE WATER TREATMENT, POLICE FORCE, FIRE DEPARTMENT, FOOD SERVICES, HOSPITAL, COMMUNICATIONS NETWORK, STEAM GENERATION, VEHICLE MAINTENANCE, TRANSPORTATION, AND A GOVERNMENT. - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  15. 12. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Riverside Avenue Bridge. Riverside, Fairfield Co., CT. Sec. 9108, MP 30.26. (See HAER No. CT-13 for further documentation on this structure). - Northeast Railroad Corridor, Amtrak Route between New York/Connecticut & Connecticut/Rhode Island State Lines, New Haven, New Haven County, CT

  16. 70. HILLSIDE AVENUE, BRONX, SUBSTATION, LOOKING SOUTH TO RAISED CONTROL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    70. HILLSIDE AVENUE, BRONX, SUBSTATION, LOOKING SOUTH TO RAISED CONTROL POARD GALLERY. VIEW DOWN ROW OF ROTARY CONVERTERS, ALTERNATING CURRENT SIDE-NOTE SLIP RINGS ON SONVERTED SHAFT JUST AT THE HUB. - Interborough Rapid Transit Subway (Original Line), New York County, NY

  17. 69. 129 HILLSIDE AVENUE, BRONX, SUBSTATION, D. C. SIDE OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    69. 129 HILLSIDE AVENUE, BRONX, SUBSTATION, D. C. SIDE OF ROTARY VISIBLE-NOTE COPPER BRUSHES IN PLACE OF SLIP RINGS. THE THREE TRANSFORMER '5'S REDUCE VOLTAGE OF CURRENT PASSING TO ROTARY '5'. NOTE ROTARY CONVERTER MOUNTED IN HARDWOOD BASE INDEPENDENT OF SUBSTATION FLOOR. - Interborough Rapid Transit Subway (Original Line), New York County, NY

  18. SAN PASCUAL AVENUE BRIDGE (WPA CONSTRUCTION 1938) OVER ARROYO SECO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    SAN PASCUAL AVENUE BRIDGE (WPA CONSTRUCTION 1938) OVER ARROYO SECO CHANNEL NORTH OF ARROYO SECO PARKWAY. LOOKING 358°N - Arroyo Seco Parkway, Arroyo Seco Bridge, Spanning Arroyo Seco at milepost 30.10, Los Angeles, Los Angeles County, CA

  19. ARROYO SECO CHANNEL SEEN FROM SAN PASCUAL AVENUE BRIDGE. NOTE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARROYO SECO CHANNEL SEEN FROM SAN PASCUAL AVENUE BRIDGE. NOTE ARROYO SECO PARKWAY AT CENTER DISTANCE. LOOKING 126°SE - Arroyo Seco Parkway, Arroyo Seco Bridge, Spanning Arroyo Seco at milepost 30.10, Los Angeles, Los Angeles County, CA

  20. VIEW EASTACROSS SOUTH CLINTON AVENUE AT MOTT STREET CENTERBUILDING 57 ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW EAST-ACROSS SOUTH CLINTON AVENUE AT MOTT STREET CENTER-BUILDING 57 FLAT SHOP NO 1 (1905) LEFT-BUILDING 51 MOTT STREET GENERATING STATION (1897) - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  1. 5. HANCOCK AVENUE NEAR HIGH WATER MARK LOOKING SOUTH TO ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. HANCOCK AVENUE NEAR HIGH WATER MARK LOOKING SOUTH TO PENNSYLVANIA MONUMENT. NOTE LINE OF MONUMENTS AND CONTEMPORARY ADAPTATION OF GUTTER, (PAVED WITH YELLOW CAUTION MARKINGS) NOT STONE LINED. VIEW S. - Gettysburg National Military Park Tour Roads, Gettysburg, Adams County, PA

  2. What Would Madison Avenue Do? Marketing to Teens

    ERIC Educational Resources Information Center

    Goodstein, Anastasia

    2008-01-01

    Whether one works for Nike or in a library, it is tough to attract an audience. That is where smart marketing can make all the difference. Even though libraries do not have millions of dollars to spend on slick Madison Avenue ad campaigns to entice today's teens, librarians do have access to the media that kids love, and that is a great place to…

  3. Contextual view of Fyffe Avenue between Jones and Boone Drives. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view of Fyffe Avenue between Jones and Boone Drives. ASA office (U.S. Border Control Environmental Office Building no. 317) is shown at center. Camera facing east. - Naval Supply Annex Stockton, Rough & Ready Island, Stockton, San Joaquin County, CA

  4. 7. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. VIEW OF CAR BARN PROPERTY AT THIRD AVENUE AND PINE STREET, LOOKING NORTHWEST FROM POWER SUBSTATION TOWARD CAR BARN, SHOWING POWER LINE DETAIL - Yakima Valley Transportation Company Interurban Railroad, Connecting towns of Yakima, Selah & Wiley City, Yakima, Yakima County, WA

  5. 22. AERIAL VIEW LOOKING EAST DOWN CENTRAL AVENUE FROM WEST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    22. AERIAL VIEW LOOKING EAST DOWN CENTRAL AVENUE FROM WEST OF THE ADMINISTRATIVE AND SUPPORT AREA OF THE PLANT. ON THE LEFT (NORTH) SIDE OF THE STREET IN THE FOREGROUND OF THE PHOTOGRAPH IS BUILDING 111, THE GENERAL ADMINISTRATION BUILDING. TO THE EAST OF BUILDING 111 IS BUILDING 112, THE CAFETERIA. FURTHER TO THE EAST IS BUILDING 331, THE VEHICLE MAINTENANCE GARAGE AND FIRE DEPARTMENT; BUILDING 333, THE PAINT SHOP; BUILDING 334, THE ELECTRICAL AND GENERAL MAINTENANCE SHOP; AND BUILDING 551, THE GENERAL WAREHOUSE. ON THE RIGHT (SOUTH) SIDE OF CENTRAL AVENUE, IN THE FOREGROUND IS BUILDING 121, FIREARMS REPAIR. BEHIND BUILDING 121 IS BUILDING 122, EMERGENCY MEDICAL SERVICES, AND BUILDING 123, HEALTH PHYSICS LABORATORY. BUILDING 441, THE PRODUCTION ... - Rocky Flats Plant, Bounded by Indiana Street & Routes 93, 128 & 72, Golden, Jefferson County, CO

  6. View of intersection of Foothill Avenue and South TwentySixth Street. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    View of intersection of Foothill Avenue and South Twenty-Sixth Street. Note sports field at center rear. Seen from Foothill Avenue at Parking Area No. 34, looking southwest - Easter Hill Village, Bordered by South Twenty-sixth Street, South Twenty-eighth Street, Hinkley Avenue, Foothill Avenue & Corto Square, Richmond, Contra Costa County, CA

  7. 53. VIEW LOOKING SOUTHWEST FROM THE CLARK AVENUE BRIDGE. REPUBLIC ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    53. VIEW LOOKING SOUTHWEST FROM THE CLARK AVENUE BRIDGE. REPUBLIC SPRAWLS ALONG 798 ACRES ON BOTH SIDES OF THE CUYAHOGA RIVER. IN THE DISTANCE, AT CENTER, BLAST FURNACES NOs. 5 AND 6 AND THE PLANT'S UPPER DOCK CAN BE SEEN. VERTICAL LEFT BRIDGE, IN FOREGROUND, CONNECTS BLAST FURNACES NOs. 1 AND 4 WITH THE STEEL FURNACE AND ROLLING MILL. - Corrigan, McKinney Steel Company, 3100 East Forty-fifth Street, Cleveland, Cuyahoga County, OH

  8. 8. PARK AVENUE EAST OF CEDAR STREET (400 Block). THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. PARK AVENUE EAST OF CEDAR STREET (400 Block). THE MARCHION HARDWARE BUILDING WAS DESIGNED BY W.W. HISLOP, AND BUILT IN 1895. THE GROUND FLOOR WAS RENOVATED SOME TIME IN THE 1930s. IN THE CENTER IS THE IMPERIAL BLOCK (ca. 1920), AND THE FULLER DRUG COMPANY (1918-1932).THE FULLER SITE WAS OCCUPIED BY THE HIGHLAND THEATER FROM 1932 TO 1972, AND RETAINS MUCH OF THE INTERIOR DECORATION FROM THAT PERIOD - Anaconda Historic District, Park & Commercial Streets, Main Street vicinity, Anaconda, Deer Lodge County, MT

  9. 80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT GUN HILL STATION. 7TH AVENUE EL EXPRESS IS VISIBLE ABOVE THE 3RD AVENUE EL WHICH JOINED ONTO THE SAME STRUCTURE AT GUN HILL ROAD. NOTE: GUN HILL ROAD IS THE NORTH TERMINUS OF THE 3RD AVENUE ELEVATED. TRAINS DID NOT CARRY PASSENGERS BEYOND THIS POINT, ALTHOUGH THE 3RD AVENUE TRACK DID EXTEND FURTHER NORTH FOR SWITCHING PURPOSES AND INTO THE YARDS. - Interborough Rapid Transit Company, Third Avenue Elevated Line, Borough of the Bronx, New York County, NY

  10. 76 FR 51029 - Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-17

    ... AGENCY Proposed CERCLA Administrative Cost Recovery Settlement; Carpenter Avenue Mercury Site, Iron... Mercury site in Iron Mountain, Dickenson County, Michigan with the following settling parties: The.... Comments should reference the Carpenter Avenue Mercury site, Iron Mountain, Dickenson County, Michigan...

  11. 2. Copy of early 20th century photograph showing Euclid Avenue ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Copy of early 20th century photograph showing Euclid Avenue facade, looking norh. Photograph owned by H.D. Koblitz. - F. B. Stearns Company, Euclid & Lakeview Avenues, Cleveland, Cuyahoga County, OH

  12. 1. MEMORIAL HALL AND COURTHOUSE/LIBRARY EAST FRONT FROM CEDAR AVENUE, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. MEMORIAL HALL AND COURTHOUSE/LIBRARY EAST FRONT FROM CEDAR AVENUE, CAMERA FACING WEST. - Lancaster County Center, Memorial Hall & Courthouse/Library, 4845 Cedar Avenue, Lancaster, Los Angeles County, CA

  13. 1. General view of underside of AbbeyAvenue branch of the ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. General view of underside of Abbey-Avenue branch of the Central viaduct (1886-1888), looking East. This bridge, like the rest of the viaduct, consists of a series of iron and steel spans, supported on iron towers resting on cut-stone foundations. The stairway visible in the photograph led from Scranton Avenue on the valley floor to the bridge deck. - Abbey Avenue Viaduct, Spanning Walworth Valley at Abbey Avenue, Cleveland, Cuyahoga County, OH

  14. Trained immunity: a new avenue for tuberculosis vaccine development.

    PubMed

    Lerm, M; Netea, M G

    2016-04-01

    Adaptive immunity towards tuberculosis (TB) has been extensively studied for many years. In addition, in recent years the profound contribution of innate immunity to host defence against this disease has become evident. The discovery of pattern recognition receptors, which allow innate immunity to tailor its response to different infectious agents, has challenged the view that this arm of immunity is nonspecific. Evidence is now accumulating that innate immunity can remember a previous exposure to a microorganism and respond differently during a second exposure. Although the specificity and memory of innate immunity cannot compete with the highly sophisticated adaptive immune response, its contribution to host defence against infection and to vaccine-induced immunity should not be underestimated and needs to be explored. Here, we present the concept of trained immunity and discuss how this may contribute to new avenues for control of TB.

  15. 33. 193195 AUBURN AVENUE (Callaway BuildingGeorgia Insurance Brokerage Inc.) (Consolidated ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    33. 193-195 AUBURN AVENUE (Callaway Building--Georgia Insurance Brokerage Inc.) (Consolidated Mortgage Building--Three Sisters Beauty Shop; Alston & Co. Realty and Property Management) NORTH ELEVATION - 126-255 Auburn Avenue (Commercial Buildings), Auburn Avenue, Atlanta, Fulton County, GA

  16. Novel avenues of drug discovery and biomarkers for diabetes mellitus.

    PubMed

    Maiese, Kenneth; Chong, Zhao Zhong; Shang, Yan Chen; Hou, Jinling

    2011-02-01

    Globally, developed nations spend a significant amount of their resources on health care initiatives that poorly translate into increased population life expectancy. As an example, the United States devotes 16% of its gross domestic product to health care, the highest level in the world, but falls behind other nations that enjoy greater individual life expectancy. These observations point to the need for pioneering avenues of drug discovery to increase life span with controlled costs. In particular, innovative drug development for metabolic disorders such as diabetes mellitus becomes increasingly critical given that the number of diabetic people will increase exponentially over the next 20 years. This article discusses the elucidation and targeting of novel cellular pathways that are intimately tied to oxidative stress in diabetes mellitus for new treatment strategies. Pathways that involve wingless, β-nicotinamide adenine dinucleotide (NAD(+)) precursors, and cytokines govern complex biological pathways that determine both cell survival and longevity during diabetes mellitus and its complications. Furthermore, the role of these entities as biomarkers for disease can further enhance their utility irrespective of their treatment potential. Greater understanding of the intricacies of these unique cellular mechanisms will shape future drug discovery for diabetes mellitus to provide focused clinical care with limited or absent long-term complications.

  17. An RNA interference screen identifies new avenues for nephroprotection.

    PubMed

    Zynda, E R; Schott, B; Gruener, S; Wernher, E; Nguyen, G D; Ebeling, M; Kandel, E S

    2016-04-01

    Acute kidney injury is a major public health problem, which is commonly caused by renal ischemia and is associated with a high risk of mortality and long-term disability. Efforts to develop a treatment for this condition have met with very limited success. We used an RNA interference screen to identify genes (BCL2L14, BLOC1S2, C2ORF42, CPT1A, FBP1, GCNT3, RHOB, SCIN, TACR1, and TNFAIP6) whose suppression improves survival of kidney epithelial cells in in vitro models of oxygen and glucose deprivation. Some of the genes also modulate the toxicity of cisplatin, an anticancer agent whose use is currently limited by nephrotoxicity. Furthermore, pharmacological inhibition of TACR1 product NK1R was protective in a model of mouse renal ischemia, attesting to the in vivo relevance of our findings. These data shed new light on the mechanisms of stress response in mammalian cells, and open new avenues to reduce the morbidity and mortality associated with renal injury.

  18. Serial Femtosecond Crystallography Opens New Avenues for Structural Biology

    PubMed Central

    Coe, Jesse; Fromme, Petra

    2016-01-01

    Free electron lasers (FELs) provide X-ray pulses in the femtosecond time domain with up to 1012 higher photon flux than synchrotrons and open new avenues for the determination of difficult to crystallize proteins, like large complexes and human membrane proteins. While the X-ray pulses are so strong that they destroy any solid material, the crystals diffract before they are destroyed. The most successful application of FELs for biology has been the method of serial femtosecond crystallography (SFX) where nano or microcrystals are delivered to the FEL beam in a stream of their mother liquid at room temperature, which ensures the replenishment of the sample before the next X-ray pulse arrives. New injector technology allows also for the delivery of crystal in lipidic cubic phases or agarose, which reduces the sample amounts for an SFX data set by two orders of magnitude. Time-resolved SFX also allows for analysis of the dynamics of biomolecules, the proof of principle being recently shown for light-induced reactions in photosystem II and photoactive yellow protein. An SFX data sets consist of thousands of single crystal snapshots in random orientations, which can be analyzed now “on the fly” by data analysis programs specifically developed for SFX, but de-novo phasing is still a challenge, that might be overcome by two-color experiments or phasing by shape transforms. PMID:26786767

  19. Avenues for genetic modification of radiation use efficiency in wheat.

    PubMed

    Reynolds, M P; van Ginkel, M; Ribaut, J M

    2000-02-01

    environment to match the demand imposed by its development. Analysis of the physiological basis of genotype by environment interactions may indicate avenues for genetic improvement. The genetic control of photosynthetic regulation may be elucidated in the future through the application of genomics. However, given a lack of specific knowledge on the genetic basis of RUE, empirical selection is currently the most powerful tool for detecting favourable genetic interactions resulting from crosses between lines with superior photosynthetic traits and other high yielding characteristics. Selection for superior segregants can be accelerated using rapidly measured physiological selection traits, such as stomatal conductance or canopy temperature depression.

  20. 53. View looking north along First Street/Dayton Avenue, across covered ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    53. View looking north along First Street/Dayton Avenue, across covered Dundee Canal prism, toward Botany Worsted Mills - Dundee Canal Industrial Historic District, Beginning at George Street in Passaic & extending north along Dundee Canal approximately 1.2 miles to Canal headgates opposite East Clifton Avenue in Clifton, Passaic, Passaic County, NJ

  1. VIEW OF CHAPEL/ADMINISTRATION BUILDING, WITH CONSTITUTION AVENUE AND “BIVOUAC OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF CHAPEL/ADMINISTRATION BUILDING, WITH CONSTITUTION AVENUE AND “BIVOUAC OF THE DEAD” PLAQUES IN FOREGROUND. VIEW TO NORTH. - Los Angeles National Cemetery, 950 South Sepulveda Boulevard, Los Angeles, Los Angeles County, CA

  2. 14. ARROYO SECO PARKWAY SEEN FROM DEBS PARK. MARMION WAY/AVENUE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    14. ARROYO SECO PARKWAY SEEN FROM DEBS PARK. MARMION WAY/AVENUE 64 BRIDGE IN FOREGROUND. YORK BOULEVARD BRIDGE IN REAR. LOOKING 28° NNE. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  3. DC66843 VIEW OF THE INDEPENDENCE AVENUE CORRIDOR SPANNED BY THE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DC-668-43 VIEW OF THE INDEPENDENCE AVENUE CORRIDOR SPANNED BY THE •DEPARTMENT OF AGRICULTURE BRIDGES, LOOKING WEST FROM TWELFTH STREET, SW - L'Enfant-McMillan Plan of Washington, DC, Washington, District of Columbia, DC

  4. 3. EXTERIOR/STREET LEVEL VIEW, LOOKING WEST ALONG FIRST AVENUE NORTH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. EXTERIOR/STREET LEVEL VIEW, LOOKING WEST ALONG FIRST AVENUE NORTH WITH (LEFT TO RIGHT) CALDWELL-MILNER, MCADORY, JOHN HAND, WOODWARD BUILDINGS AND BROWN MARX BUILDING (RIGHT). ALSO PICTURED IS THE BANK FOR SAVINGS BUILDING (TOP RIGHT) AND THE RAILROAD RESERVATION (TOP LEFT TO RIGHT). VIEW TAKEN AS CITY THAWS FROM A MARCH BLIZZARD. - Heaviest Corner on Earth (Commercial), First Avenue, North & Twentieth (20th) Street, North, Birmingham, Jefferson County, AL

  5. Lawrence Livermore National Laboratory East Avenue/Emergency Response Planning Traffic Study

    SciTech Connect

    Schmiegel, T

    2002-02-15

    The Lawrence Livermore National Laboratory (LLNL) and the Sandia National Laboratory (SNL) are located at the eastern end of the City of Livermore. Recently the research facilities have been placed on heightened security alerts due to the events of September 11. To respond to the security concerns, LLNL and SNL have proposed to place East Avenue between South Vasco Road and Greenville Road under administrative control. This type of control would require security check points at both ends of this segment of East Avenue, including a truck inspection facility west of the Greenville Road intersection. In this configuration, East Avenue would be closed to general public traffic. The purpose of this traffic study is to determine the potential traffic impact of placing East Avenue under administrative control. The primary focus of the traffic study is to evaluate the proposed modifications to the geometry and operation of East Avenue between South Vasco Road and Greenville Road. The study also includes a review of a traffic study prepared for the closure of East Avenue in 1989 to determine if the assumptions and conclusions of that study remain valid.

  6. Multi-Uses of Compensatory Programs in Reinforcing the Curriculum of Two Inner-City Schools: English Avenue Elementary School; English Avenue Primary School; 1972-73. Research and Development Report, Volume 7, Number 8, September 1973.

    ERIC Educational Resources Information Center

    Goettee, Margaret; Watts, Larry

    There are two schools bearing the name English Avenue: English Avenue Elementary School and English Avenue Primary School. The primary school, which is within the zone boundaries of the elementary school, provided grades kindergarten through 2; the Follow Through Program operated at all three grade levels. After grade two, the pupils of the…

  7. Investment Avenues

    NASA Astrophysics Data System (ADS)

    Jain, Priyanka

    2012-11-01

    Investors are a heterogeneous group, they may be large or small, rich or poor, expert or lay man and not all investors need equal degree of protection (Mayya, 1996). An investor has three objectives while investing his money, namely safety of invested money, liquidity position of invested money and return on investment. The return on investment may further be divided into capital gain and the rate of return on investment as interest or dividend. Among all investment options available, securities are considered the most challenging as well as rewarding. Securities include shares, debentures, derivatives, units of mutual funds, Government securities etc. An investor may be an individual or corporate legal entity investing funds with a view to derive maximum economic advantage from investment such as rate of return, capital appreciation, marketability, tax advantage and convenience of investment.The Capital market facilitates mobilization of savings of individuals and pools them into reservoir of capital which can be used for the economic development of a country. An efficient capital market is essential for raising capital by the corporate sector of the economy and for the protection of the interest of investors in corporate securities. There arises a need to strike a balance between raising of capital for economic development on one side and protection of investors on the other. Unless the interests of investors are protected, raising of capital, by corporates is not possible. Like, the primary objective of a senior citizenís asset allocation is the generation of regular income.

  8. VIEW SOUTHEAST ACROSS HAMILTON AVENUE LEFTBUILDING 114ELMER STREET ROPE SHOP ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW SOUTHEAST ACROSS HAMILTON AVENUE LEFT-BUILDING 114-ELMER STREET ROPE SHOP NORTH EXTENSION (1929) RIGHT-BUILDING 110-CARPENTER SHOP (1908) - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  9. VIEW SOUTHACROSS HAMILTON AVENUE BY CLARK STREET CENTER REARBUILDING 101CLARK ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW SOUTH-ACROSS HAMILTON AVENUE BY CLARK STREET CENTER REAR-BUILDING 101-CLARK STREET ROPE SHOP (1917) CLARK STREET WATER TOWER (1908 RIGHT-BUILDING 114 ELMER STREET ROPE SHOP NORTH EXTENSION (1929) - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  10. 75 FR 17139 - Proposed CERCLA Section 122(h) Cost Recovery Settlement for the Kentucky Avenue Wellfield...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-05

    ... AGENCY Proposed CERCLA Section 122(h) Cost Recovery Settlement for the Kentucky Avenue Wellfield Superfund Site, Town of Horseheads and Village of Horseheads, Chemung County, NY AGENCY: Environmental... (``CERCLA''), 42 ] U.S.C. 9622(i), notice is hereby given by the U.S. Environmental Protection Agency...

  11. Expanding the Teaching Games for Understanding Model: New Avenues for Future Research and Practice.

    ERIC Educational Resources Information Center

    Holt, Nicholas L.; Strean, William B.; Bengoechea, Enrique Garcia

    2002-01-01

    Reviews research on the Teaching Games for Understanding (TGfU) approach in physical education, noting that many discussions of TGfU have focused on cognitive and psychomotor learning outcomes and neglected the affective domain. An extended TGfU model is presented, suggesting new avenues for future research and practice (e.g., consideration of…

  12. VIEW NORTHSOUTH CLINTON AVENUE LEFTBUILDING 10CLINTON STREET STOREHOUSE (1927) CENTERBUILDING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW NORTH-SOUTH CLINTON AVENUE LEFT-BUILDING 10-CLINTON STREET STOREHOUSE (1927) CENTER-BUILDING 35-ELMER STREET WIRE MILL (1899) RIGHT-BUILDING 54-FLAT SHOP 3 A (1924) - John A. Roebling's Sons Company & American Steel & Wire Company, South Broad, Clark, Elmer, Mott & Hudson Streets, Trenton, Mercer County, NJ

  13. Avenues to Prestige among Adolescents in Public and Religiously Affiliated High Schools

    ERIC Educational Resources Information Center

    Suitor, J. Jill; Powers, Rebecca S.; Brown, Rachel

    2004-01-01

    We used data from 1,733 college students to explore whether adolescents' avenues to prestige differ in public and private high schools. Students attending seven large universities during the 1997-98 academic year provided information on the ways in which adolescents in their high schools had gained prestige with peers. The analyses revealed no…

  14. 166. GENERAL VIEW DOWN 4TH AVENUE. VIEW NORTHEAST DOWN 4TH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    166. GENERAL VIEW DOWN 4TH AVENUE. VIEW NORTHEAST DOWN 4TH AVE. FROM BUILDING 44 SHOWING, FROM LEFT TO RIGHT, BUILDING 46, 48, 55, AND 50 (PART OF ENLISTED BARRACKS COMPLEX), AND BUILDINGS 17, 16, 484, 483, 374, AND 375 (IN THE WAREHOUSE COMPLEX). - Quonset Point Naval Air Station, Roger Williams Way, North Kingstown, Washington County, RI

  15. Participation Observation: Chinese Mothers and Children at Rhodes Avenue English Classes.

    ERIC Educational Resources Information Center

    Lenskyj, Helen

    Observations of Chinese mothers and children at Rhodes Avenue (Toronto) English classes and nursery confirm the hypothesis that a high level of parental warmth-support and control tends to become, by Canadian standards, overprotectiveness, and tends to result in a submissive, dependent, over-socialized child. Dependency upon the mother for…

  16. Walnut Springs Interest Unit, Fairmount Avenue School. Primary Unit--Team I.

    ERIC Educational Resources Information Center

    State College Area School District, PA.

    This environmental education teaching guide was designed for primary teachers who may want to develop their own environmental education units or who may wish to integrate the units contained in the guide into their own curriculum. The units in the guide were developed by primary teachers and reflect the experiences of the Fairmont Avenue School…

  17. DC66822 VIEW SOUTH TOWARD VIRGINIA AVENUE AND TO WEST POTOMAC ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    DC-668-22 VIEW SOUTH TOWARD VIRGINIA AVENUE AND TO WEST POTOMAC PARK BEYOND FROM THE ROOF OF THE DEPARTMENT OF THE INTERIOR AT 19TH AND C STREETS, NW - L'Enfant-McMillan Plan of Washington, DC, Washington, District of Columbia, DC

  18. Improving Critical Thinking Skills Using Learning Model Logan Avenue Problem Solving (LAPS)-Heuristic

    ERIC Educational Resources Information Center

    Anggrianto, Desi; Churiyah, Madziatul; Arief, Mohammad

    2016-01-01

    This research was conducted in order to know the effect of Logan Avenue Problem Solving (LAPS)-Heuristic learning model towards critical thinking skills of students of class X Office Administration (APK) in SMK Negeri 1 Ngawi, East Java, Indonesia on material curve and equilibrium of demand and supply, subject Introduction to Economics and…

  19. 75 FR 76036 - American Axle & Manufacturing Detroit Manufacturing Complex Holbrook Avenue and Saint Aubin...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-07

    ... Avenue and Saint Aubin Including On-Site Leased Workers From Paint Tech International Detroit, MI... from Paint Tech International were employed on-site at the Detroit, Michigan location of American Axle..., the Department is amending this certification to include workers leased from Paint Tech...

  20. 19. View to the north of Riverside Avenue. AZ196(J. C. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. View to the north of Riverside Avenue. AZ-196(J. C. Gatti House) at left Part of AZ-197 (Shannon Copper Company Store) can be seen in group of buildings at right - Clifton Townsite, Confluence of Chase Creek & San Francisco River, Clifton, Greenlee County, AZ

  1. 76 FR 22729 - Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plant #1, Including On-Site Leased...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-22

    ... Employment and Training Administration Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plant 1... to Apply for Worker Adjustment Assistance on April 6, 2011, applicable to workers of Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plant 1, including on-site leased workers of...

  2. Dale Avenue Performance Objective Model Pre-Primary-Primary Performance Objectives Prekindergarten Through Grade Three: Manual; Record Book.

    ERIC Educational Resources Information Center

    Hanson, Helen B.; Gavzy, Rita

    The Dale Avenue Early Childhood Education Project was developed in the Dale Avenue School in Paterson, New Jersey through funding from the Elementary Secondary Education Act Title III. The Project was validated in 1973 by the standards and guidelines of the U.S. Office of Education as innovative, successful, cost effective, and exportable. As a…

  3. The Copenhagen Accord for limiting global warming: criteria, constraints, and available avenues.

    PubMed

    Ramanathan, Veerabhadran; Xu, Yangyang

    2010-05-04

    At last, all the major emitters of greenhouse gases (GHGs) have agreed under the Copenhagen Accord that global average temperature increase should be kept below 2 degrees C. This study develops the criteria for limiting the warming below 2 degrees C, identifies the constraints imposed on policy makers, and explores available mitigation avenues. One important criterion is that the radiant energy added by human activities should not exceed 2.5 (range: 1.7-4) watts per square meter (Wm(-2)) of the Earth's surface. The blanket of man-made GHGs has already added 3 (range: 2.6-3.5) Wm(-2). Even if GHG emissions peak in 2015, the radiant energy barrier will be exceeded by 100%, requiring simultaneous pursuit of three avenues: (i) reduce the rate of thickening of the blanket by stabilizing CO(2) concentration below 441 ppm during this century (a massive decarbonization of the energy sector is necessary to accomplish this Herculean task), (ii) ensure that air pollution laws that reduce the masking effect of cooling aerosols be made radiant energy-neutral by reductions in black carbon and ozone, and (iii) thin the blanket by reducing emissions of short-lived GHGs. Methane and hydrofluorocarbons emerge as the prime targets. These actions, even if we are restricted to available technologies for avenues ii and iii, can reduce the probability of exceeding the 2 degrees C barrier before 2050 to less than 10%, and before 2100 to less than 50%. With such actions, the four decades we have until 2050 should be exploited to develop and scale-up revolutionary technologies to restrict the warming to less than 1.5 degrees C.

  4. Avenue to understanding the mechanism of radiation effects. extended serial sacrifice experimental methodology

    SciTech Connect

    Neyman, J.

    1980-01-01

    The visualized avenue towards understanding the mechanism of the effects of radiation on the health of animals used in the experiments is, primarily, through willing interested cooperation between experimenting biologists, on the one hand, and equally willing and interested mathematical statisticians on the other. A review of the developments over two recent decades leads the author to the following conclusions relating to experimental designs; (1) the design of survival experiments with serial sacrifices as proposed by Arther C. Upton is basic, but (2) This design needs an extension. The building of this extension depends very much on the inventiveness of experimenting biologists.

  5. HOT CELL BUILDING, TRA632. CONTEXTUAL VIEW ALONG WALLEYE AVENUE, CAMERA ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HOT CELL BUILDING, TRA-632. CONTEXTUAL VIEW ALONG WALLEYE AVENUE, CAMERA FACING EASTERLY. HOT CELL BUILDING IS AT CENTER LEFT OF VIEW; THE LOW-BAY PROJECTION WITH LADDER IS THE TEST TRAIN ASSEMBLY FACILITY, ADDED IN 1968. MTR BUILDING IS IN LEFT OF VIEW. HIGH-BAY BUILDING AT RIGHT IS THE ENGINEERING TEST REACTOR BUILDING, TRA-642. INL NEGATIVE NO. HD46-32-1. Mike Crane, Photographer, 4/2005 - Idaho National Engineering Laboratory, Test Reactor Area, Materials & Engineering Test Reactors, Scoville, Butte County, ID

  6. 76 FR 27366 - Chrysler Group, LLC, Power Train Division, Mack Avenue Engine Plants #1 And #2, Including On-Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-11

    ... Division. Together, the Mack Avenue Engine Plants 1 and 2 are part of an integrated production process for... Caravan Knight, Detroit, Michigan. The workers are engaged in the production of automotive engines....

  7. Pollutant Concentrations in Street Canyons of Different Aspect Ratio with Avenues of Trees for Various Wind Directions

    NASA Astrophysics Data System (ADS)

    Gromke, Christof; Ruck, Bodo

    2012-07-01

    This study summarizes the effects of avenues of trees in urban street canyons on traffic pollutant dispersion. We describe various wind-tunnel experiments with different tree-avenue models in combination with variations in street-canyon aspect ratio W/ H (with W the street-canyon width and H the building height) and approaching wind direction. Compared to tree-free street canyons, in general, higher pollutant concentrations are found. Avenues of trees do not suppress canyon vortices, although the air ventilation in canyons is hindered significantly. For a perpendicular wind direction, increases in wall-average and wall-maximum concentrations at the leeward canyon wall and decreases in wall-average concentrations at the windward wall are found. For oblique and perpendicular wind directions, increases at both canyon walls are obtained. The strongest effects of avenues of trees on traffic pollutant dispersion are observed for oblique wind directions for which also the largest concentrations at the canyon walls are found. Thus, the prevailing assumption that attributes the most harmful dispersion conditions to a perpendicular wind direction does not hold for street canyons with avenues of trees. Furthermore, following dimensional analysis, an estimate of the normalized wall-maximum traffic pollutant concentration in street canyons with avenues of trees is derived.

  8. Avenues into Food Planning: A Review of Scholarly Food System Research

    PubMed Central

    Brinkley, Catherine

    2014-01-01

    This review summarizes several avenues of planning inquiry into food systems research, revealing gaps in the literature, allied fields of study and mismatches between scholarly disciplines and the food system life cycle. Planners and scholars in associated fields have identified and defined problems in the food system as ‘wicked’ problems, complex environmental issues that require systemic solutions at the community scale. While food justice scholars have contextualized problem areas, planning scholars have made a broad case for planning involvement in solving these wicked problems while ensuring that the functional and beneficial parts of the food system continue to thrive. This review maps the entry points of scholarly interest in food systems and planning’s contributions to its study, charting a research agenda for the future. PMID:24932131

  9. From the blood to the brain: avenues of eukaryotic pathogen dissemination to the central nervous system.

    PubMed

    Ueno, Norikiyo; Lodoen, Melissa B

    2015-08-01

    Infection of the central nervous system (CNS) is a significant cause of morbidity and mortality, and treatments available to combat the highly debilitating symptoms of CNS infection are limited. The mechanisms by which pathogens in the circulation overcome host immunity and breach the blood-brain barrier are active areas of investigation. In this review, we discuss recent work that has significantly advanced our understanding of the avenues of pathogen dissemination to the CNS for four eukaryotic pathogens of global health importance: Toxoplasma gondii, Plasmodium falciparum, Trypanosoma brucei, and Cryptococcus neoformans. These studies highlight the remarkable diversity of pathogen strategies for trafficking to the brain and will ultimately contribute to an improved ability to combat life-threatening CNS disease.

  10. Results of the radiological survey at 1052 Central Avenue, Albany, New York (AL208)

    SciTech Connect

    Hall, S.C.; Marley, J.L.

    1987-11-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 1052 Central Avenue in Albany, New York, was the subject of a radiological investigation initiated August 26, 1986. The residential property consists of a two-story block and frame house with a separate garage located on a rectangular lot. An asphalt driveway connects the garage to the street. A diagram of the property showing the approximate boundaries and a 6-m grid network established for measurements outside the house is shown. The lot included in the radiological survey was /approximately/17.5 m wide by 43.5 m deep. Front and side views of the property are shown. 13 refs., 5 figs., 5 tabs.

  11. Results of the radiological survey at 1054 Central Avenue, Albany, New York (AL211)

    SciTech Connect

    Hall, S.C.; Marley, J.L.

    1987-11-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 1054 Central Avenue in Albany, New York was the subject of a radiological investigation initiated August 27, 1986. The commercial property consists of a two-story frame and block building located on a rectangular lot. An asphalt drive connects the working areas to the street. A diagram of the property showing the approximate boundaries and the 5-m grid network established for measurements outside the building is shown. The lot included in the radiological survey was /approximately/13 m wide by 43 m deep. Front and side views of the property are shown. 13 refs., 5 figs., 5 tabs.

  12. Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues.

    PubMed

    Rauen, Katherine A; Huson, Susan M; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H; Zenker, Martin; Upadhyaya, Meena

    2015-01-01

    Neurofibromatosis type 1 (NF1) was the first RASopathy and is now one of many RASopathies that are caused by germline mutations in genes that encode components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Their common underlying pathogenetic etiology causes significant overlap in phenotypic features which includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, GI and ocular abnormalities, and a predisposition to cancer. The proceedings from the symposium "Recent Developments in Neurofibromatoses (NF) and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues" chronicle this timely and topical clinical translational research symposium. The overarching goal was to bring together clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and individuals with Ras pathway syndromes to discuss the most state-of-the-art basic science and clinical issues in an effort to spark collaborations directed towards the best practices and therapies for individuals with RASopathies.

  13. Arc View/Avenue: Coding styles and utility scripts for efficient development

    SciTech Connect

    Ganter, J.

    1996-05-07

    Effectiveness and efficiency of software development can be greatly increased by writing modularized code using informal (styles) and formal (standards) work approaches. Software development is about connecting pieces into a coherent whole. Thus consistent work approaches provide a structure that allows individuals and teams to minimize the time and thought put into making these connections. These investments in structure return even more benefits in the maintenance phase when old code has to be examined by new programmers, or after time has passed. We present some examples of coding style for Avenue: a simplified form of Hungarian notation (notationHungarian, stringCustomerName, etc.), script naming prefixes and suffixes, and options in script headers. We demonstrate several modular, object-like utility scripts that can be used alone or combined into other utilities. These include developer tools such as a System.Echo substitute for Windows, a Window inspector, and a script for detecting and dealing with multiple display resolutions.

  14. Results of the radiological survey at 1110 Central Avenue, Albany, New York (AL215)

    SciTech Connect

    Marley, J.L.; Carrier, R.F.

    1988-02-01

    A number of properties in the Albany/Colonie area have been identified as being potentially contaminated with uranium originating from the former National Lead Company's uranium forming plant in Colonie, New York. The property at 1110 Central Avenue in Albany, New York (AL215) was the subject of a radiological investigation initiated May 4, 1987. This commercial property consists of a one-story concrete block office building (Building 1), a one-story concrete block warehouse (Building 2), and four connected storage buildings constructed variously of wood, metal, or concrete block. The structures are situated on an irregularly shaped lot. A diagram of the property showing the approximate boundaries and the 10-m grid network established for measurements outside the buildings is shown. The lot included in the radiological survey was /approximately/45 m wide by 98 m deep. Two views of the property are shown. 13 refs., 6 figs., 5 tabs.

  15. The microbiome and its pharmacological targets: therapeutic avenues in cardiometabolic diseases.

    PubMed

    Neves, Ana Luisa; Chilloux, Julien; Sarafian, Magali H; Rahim, Mohd Badrin Abdul; Boulangé, Claire L; Dumas, Marc-Emmanuel

    2015-12-01

    Consisting of trillions of non-pathogenic bacteria living in a symbiotic relationship with their mammalian host, the gut microbiota has emerged in the past decades as one of the key drivers for cardiometabolic diseases (CMD). By degrading dietary substrates, the gut microbiota produces several metabolites that bind human pharmacological targets, impact subsequent signalling networks and in fine modulate host's metabolism. In this review, we revisit the pharmacological relevance of four classes of gut microbial metabolites in CMD: short-chain fatty acids (SCFA), bile acids, methylamines and indoles. Unravelling the signalling mechanisms of the microbial-mammalian metabolic axis adds one more layer of complexity to the physiopathology of CMD and opens new avenues for the development of microbiota-based pharmacological therapies.

  16. Avenues into Food Planning: A Review of Scholarly Food System Research.

    PubMed

    Brinkley, Catherine

    2013-04-01

    This review summarizes several avenues of planning inquiry into food systems research, revealing gaps in the literature, allied fields of study and mismatches between scholarly disciplines and the food system life cycle. Planners and scholars in associated fields have identified and defined problems in the food system as 'wicked' problems, complex environmental issues that require systemic solutions at the community scale. While food justice scholars have contextualized problem areas, planning scholars have made a broad case for planning involvement in solving these wicked problems while ensuring that the functional and beneficial parts of the food system continue to thrive. This review maps the entry points of scholarly interest in food systems and planning's contributions to its study, charting a research agenda for the future.

  17. Novel genomic techniques open new avenues in the analysis of monogenic disorders.

    PubMed

    Kuhlenbäumer, Gregor; Hullmann, Julia; Appenzeller, Silke

    2011-02-01

    The molecular genetic cause of over 3,000 monogenic disorders is currently unknown. This review discusses how novel genomic techniques like Next-Generation DNA Sequencing (NGS) and genotyping arrays open new avenues in the elucidation of genetic defects causing monogenic disorders. They will not only speed up disease gene identification but will enable us to systematically tackle previously intractable monogenic disorders. These are mainly disorders not amenable to classic linkage analysis, for example, due to insufficient family size. Most monogenic diseases are caused by exonic mutations or splice-site mutations changing the amino acid sequence of the affected gene. These mutations can be identified by sequencing of all exons in the human genome (exome sequencing) rendering whole genome sequencing unnecessary in most cases. Genotyping arrays containing 10⁵ -2×10⁶ single nucleotide polymorphisms (SNPs) and nonpolymorphic markers allow highly accurate mapping of genomic deletions and duplications not detectable by exome sequencing, which are the second most common cause of monogenic disorders. However, several hundred rare, previously unknown sequence variants affecting the amino acid sequence of the encoded protein are found in the exome of every human individual. Therefore, the main challenge will be the differentiation between the many rare benign variants detected by novel genomic techniques and disease causing mutations.

  18. A systematic review of satisfaction and pediatric obesity treatment: new avenues for addressing attrition.

    PubMed

    Skelton, Joseph A; Irby, Megan Bennett; Geiger, Ann M

    2014-01-01

    Pediatric obesity treatment programs report high attrition rates, but it is unknown if family experience and satisfaction contributes. This review surveys the literature regarding satisfaction in pediatric obesity and questions used in measurement. A systematic review of the literature was conducted using Medline, PsychINFO, and CINAHL. Studies of satisfaction in pediatric weight management were reviewed, and related studies of obesity were included. Satisfaction survey questions were obtained from the articles or from the authors. Eighteen studies were included; 14 quantitative and 4 qualitative. Only one study linked satisfaction to attrition, and none investigated the association of satisfaction and weight outcomes. Most investigations included satisfaction as a secondary aim or used single-item questions of overall satisfaction; only one assessed satisfaction in noncompleters. Overall, participants expressed high levels of satisfaction with obesity treatment or prevention programs. Surveys focused predominantly on overall satisfaction or specific components of the program. Few in-depth studies of satisfaction with pediatric obesity treatment have been conducted. Increased focus on family satisfaction with obesity treatment may provide an avenue to lower attrition rates and improve outcomes. Enhancing measurement of satisfaction to yield actionable responses could positively influence outcomes, and a framework, via patient-centered care principles, is provided.

  19. Paradoxical thinking as a new avenue of intervention to promote peace.

    PubMed

    Hameiri, Boaz; Porat, Roni; Bar-Tal, Daniel; Bieler, Atara; Halperin, Eran

    2014-07-29

    In societies involved in an intractable conflict, there are strong socio-psychological barriers that contribute to the continuation and intractability of the conflict. Based on a unique field study conducted in the context of the Israeli-Palestinian conflict, we offer a new avenue to overcome these barriers by exposing participants to a long-term paradoxical intervention campaign expressing extreme ideas that are congruent with the shared ethos of conflict. Results show that the intervention, although counterintuitive, led participants to express more conciliatory attitudes regarding the conflict, particularly among participants with center and right political orientation. Most importantly, the intervention even influenced participants' actual voting patterns in the 2013 Israeli general elections: Participants who were exposed to the paradoxical intervention, which took place in proximity to the general elections, reported that they tended to vote more for dovish parties, which advocate a peaceful resolution to the conflict. These effects were long lasting, as the participants in the intervention condition expressed more conciliatory attitudes when they were reassessed 1 y after the intervention. Based on these results, we propose a new layer to the general theory of persuasion based on the concept of paradoxical thinking.

  20. New avenues for reducing intensive care needs in patients with chronic spinal cord injury

    PubMed Central

    Guertin, Pierre A

    2016-01-01

    Relatively soon after their accident, patients suffering a spinal cord injury (SCI) begin generally experiencing the development of significant, often life-threatening secondary complications. Many of which are associated with chronic physical inactivity-related immune function problems and increasing susceptibility to infection that repeatedly requires intensive care treatment. Therapies capable of repairing the spinal cord or restoring ambulation would normally prevent many of these problems but, as of now, there is no cure for SCI. Thus, management strategies and antibiotics remain the standard of care although antimicrobial resistance constitutes a significant challenge for patients with chronic SCI facing recurrent infections of the urinary tract and respiratory systems. Identifying alternative therapies capable of safe and potent actions upon these serious health concerns should therefore be considered a priority. This editorial presents some of the novel approaches currently in development for the prevention of specific infections after SCI. Among them, brain-permeable small molecule therapeutics acting centrally on spinal cord circuits that can augment respiratory capabilities or bladder functions. If eventually approved by regulatory authorities, some of these new avenues may potentially become clinically-relevant therapies capable of indirectly preventing the occurrence and/or severity of these life-threatening complications in people with paraplegic or tetraplegic injuries. PMID:27896143

  1. Reproductive delays in mammals: an unexplored avenue for post-copulatory sexual selection.

    PubMed

    Orr, Teri J; Zuk, Marlene

    2014-11-01

    Numerous mammalian taxa exhibit reproductive delays, pauses in reproduction that occur between mating and fertilization, between fertilization and implantation of the embryo, or after an embryo has implanted. Of the 27 mammalian orders, 9 are known to exhibit reproductive delays, including Diptrotodontia, Dasyuromorphia, Eulipotyphyta, Cingulata, Carnivora, Rodentia, Chiroptera, Lagomorpha and Cetartiodactyla. Most researchers interested in delays have focused on their evolutionary origins. However, the consequences of these delays have not been considered fully. Given the lengthening of the period over which reproduction occurs, it is possible that this unique aspect of reproduction facilitates post-copulatory sexual selection. When considered in the context of sexual selection, delays may allow sperm competition and female manipulation of fertilization (cryptic female choice) as well as other post-copulatory processes. We investigate the potential for reproductive delays to facilitate post-copulatory sexual selection and suggest avenues for research that may further our knowledge of sexual selection. We also provide a general review of reproductive delays in mammals.

  2. Invited commentary: Personality phenotype and mortality--new avenues in genetic, social, and clinical epidemiology.

    PubMed

    Chapman, Benjamin P

    2013-09-01

    In this issue of the Journal, Jokela et al. (Am J Epidemiol. 2013;178(5):667-675) scrutinize the association between personality phenotype and all-cause mortality in remarkable detail by using an "individual-participant meta-analysis" design. Across 7 large cohorts varying in demographics and methods of personality measurement, they find varying prospective associations for 4 dimensions of the five-factor (or "Big Five") model of personality, but robust and consistent prospective associations for Big Five dimension of "conscientiousness." Jokela et al. place an important exclamation point on a long era of study of this topic and hint directly and indirectly at new avenues for this line of research. I consider the following 3 areas particularly rife for further inquiry: the role of genetics in personality and health studies; the role of personality in social inequalities in health; and the health policy and clinical implications of work like that of Jokela et al., including the potential role of personality phenotype in the evolution of personalized medicine.

  3. Repopulating Decellularized Kidney Scaffolds: An Avenue for Ex Vivo Organ Generation

    PubMed Central

    McKee, Robert A.; Wingert, Rebecca A.

    2016-01-01

    Recent research has shown that fully developed organs can be decellularized, resulting in a complex scaffold and extracellular matrix (ECM) network capable of being populated with other cells. This work has resulted in a growing field in bioengineering focused on the isolation, characterization, and modification of organ derived acellular scaffolds and their potential to sustain and interact with new cell populations, a process termed reseeding. In this review, we cover contemporary advancements in the bioengineering of kidney scaffolds including novel work showing that reseeded donor scaffolds can be transplanted and can function in recipients using animal models. Several major areas of the field are taken into consideration, including the decellularization process, characterization of acellular and reseeded scaffolds, culture conditions, and cell sources. Finally, we discuss future avenues based on the advent of 3D bioprinting and recent developments in kidney organoid cultures as well as animal models of renal genesis. The ongoing mergers and collaborations between these fields hold the potential to produce functional kidneys that can be generated ex vivo and utilized for kidney transplantations in patients suffering with renal disease. PMID:27375844

  4. Chemical Exfoliation of Layered Superconductors: An Avenue to Synthesize Boron-rich Quasi Two Dimensional Nanostructures

    NASA Astrophysics Data System (ADS)

    Das, Saroj Kumar; Liza James, Asha; Jasuja, Kabeer

    2015-03-01

    Zero-dimensional and one-dimensional boron based nanostructures have presented excellent avenues in the past for utilizing the fascinating science of boron at the atomic level. The research on synthesizing two-dimensional (2-D) boron-based nanostructures is currently in its incipient stages. In this talk, we demonstrate two chemical approaches that yield quasi 2-D boron-rich nanostructures by enabling an exfoliation of a layered boron-based superconductor. While one approach employs the simple tool of ultrasonication in an aqueous phase, the other approach utilizes a chelation mediated strategy based on coordination of metal ions and organic ligands. Both these synthetic routes are shown to result in a processable colloidal dispersion of nanosheets. This talk will present details of the two exfoliation approaches and a comprehensive study of the morphological, chemical and optical properties of the dispersed nanosheets. We will demonstrate that the exfoliated nanosheets undergo an in-situ chemical modification with ionizable functional groups derived from solvent that enable electrostatic stabilization. We will further shown that this functionalization modifies the band structure of the nanosheets which gives rise to photoluminescence and result in physico-chemical properties distinct from the parent superconductor. This ability to synthesize quasi 2-D boron rich nanostructures significantly adds to the current state of literature on born-based quasi-planar nanostructures.

  5. Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes.

    PubMed

    Wang, Hua H; Manuzon, Michele; Lehman, Mark; Wan, Kai; Luo, Hongliang; Wittum, Thomas E; Yousef, Ahmed; Bakaletz, Lauren O

    2006-01-01

    The rapid emergence of antibiotic-resistant (ART) pathogens is a major threat to public health. While the surfacing of ART food-borne pathogens is alarming, the magnitude of the antibiotic resistance (AR) gene pool in food-borne commensal microbes is yet to be revealed. Incidence of ART commensals in selected retail food products was examined in this study. The presence of 10(2)-10(7) CFU of ART bacteria per gram of foods in many samples, particularly in ready-to-eat, 'healthy' food items, indicates that the ART bacteria are abundant in the food chain. AR-encoding genes were detected in ART isolates, and Streptococcus thermophilus was found to be a major host for AR genes in cheese microbiota. Lactococcus lactis and Leuconostoc sp. isolates were also found carrying AR genes. The data indicate that food could be an important avenue for ART bacterial evolution and dissemination. AR-encoding plasmids from several food-borne commensals were transmitted to Streptococcus mutans via natural gene transformation under laboratory conditions, suggesting the possible transfer of AR genes from food commensals to human residential bacteria via horizontal gene transfer.

  6. Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy

    PubMed Central

    Tobe, Ryuta; Carlson, Bradley A.; Tsuji, Petra A.; Lee, Byeong Jae; Gladyshev, Vadim N.; Hatfield, Dolph L.

    2015-01-01

    A common characteristic of many cancer cells is that they suffer from oxidative stress. They, therefore, require effective redox regulatory systems to combat the higher levels of reactive oxygen species that accompany accelerated growth compared to the normal cells of origin. An elevated dependence on these systems in cancers suggests that targeting these systems may provide an avenue for retarding the malignancy process. Herein, we examined the redox regulatory systems in human liver and lung cancers by comparing human lung adenocarcinoma and liver carcinoma to their respective surrounding normal tissues. Significant differences were found in the two major redox systems, the thioredoxin and glutathione systems. Thioredoxin reductase 1 levels were elevated in both malignancies, but thioredoxin was highly upregulated in lung tumor and only slightly upregulated in liver tumor, while peroxiredoxin 1 was highly elevated in lung tumor, but downregulated in liver tumor. There were also major differences within the glutathione system between the malignancies and their normal tissues. The data suggest a greater dependence of liver on either the thioredoxin or glutathione system to drive the malignancy, while lung cancer appeared to depend primarily on the thioredoxin system. PMID:26569310

  7. New avenues for treating emotional memory disorders: towards a reconsolidation intervention for posttraumatic stress disorder

    PubMed Central

    Kindt, Merel; van Emmerik, Arnold

    2016-01-01

    The discovery that fear memories may change upon retrieval, a process referred to as memory reconsolidation, opened avenues to develop a revolutionary new treatment for emotional memory disorders. Reconsolidation is a two-phase process in which retrieval of a memory initiates a transient period of memory destabilization, followed by a protein synthesis-dependent restabilization phase. This reconsolidation window offers unique opportunities for amnesic agents to interfere with the process of memory restabilization, thereby weakening or even erasing the emotional expression from specific fear memories. Here we present four uncontrolled case descriptions of patients with symptoms of posttraumatic stress disorder (PTSD) who received a reconsolidation intervention. The intervention basically involves a brief reactivation of the trauma memory aimed to trigger memory destabilization, followed by the intake of one pill of 40 mg propranolol HCl (i.e. a noradrenergic beta-blocker) that should disrupt the process of memory restabilization. We present three cases who showed a steep decline of fear symptoms after only one or two intervention sessions. To illustrate that the translation from basic science to clinical practice is not self-evident, we also present a description of a noneffective intervention in a relatively complex case. Even though the reconsolidation intervention is very promising, the success of the treatment depends on whether the memory reactivation actually triggers memory reconsolidation. Obviously the uncontrolled observations described here warrant further study in placebo-controlled designs. PMID:27536348

  8. Paradoxical thinking as a new avenue of intervention to promote peace

    PubMed Central

    Hameiri, Boaz; Porat, Roni; Bar-Tal, Daniel; Bieler, Atara; Halperin, Eran

    2014-01-01

    In societies involved in an intractable conflict, there are strong socio-psychological barriers that contribute to the continuation and intractability of the conflict. Based on a unique field study conducted in the context of the Israeli–Palestinian conflict, we offer a new avenue to overcome these barriers by exposing participants to a long-term paradoxical intervention campaign expressing extreme ideas that are congruent with the shared ethos of conflict. Results show that the intervention, although counterintuitive, led participants to express more conciliatory attitudes regarding the conflict, particularly among participants with center and right political orientation. Most importantly, the intervention even influenced participants' actual voting patterns in the 2013 Israeli general elections: Participants who were exposed to the paradoxical intervention, which took place in proximity to the general elections, reported that they tended to vote more for dovish parties, which advocate a peaceful resolution to the conflict. These effects were long lasting, as the participants in the intervention condition expressed more conciliatory attitudes when they were reassessed 1 y after the intervention. Based on these results, we propose a new layer to the general theory of persuasion based on the concept of paradoxical thinking. PMID:25024185

  9. Vascular Toxicities of Cancer Therapies: The Old and The New – An Evolving Avenue

    PubMed Central

    Herrmann, Joerg; Yang, Eric H.; Iliescu, Cezar; Cilingiroglu, Mehmet; Charitakis, Konstantinos; Hakeem, Abdul; Toutouzas, Konstantinos; Leesar, Massoud A.; Grines, Cindy L.; Marmagkiolis, Konstantinos

    2016-01-01

    Since the late 1990s, there has been a steady decline in cancer-related mortality, in part related to the introduction of so-called “targeted therapies”. Intended to interfere with a specific molecular pathway, these therapies have, paradoxically, led to a number of “off-target” effects. The latest examples are tyrosine kinase inhibitors targeting the Philadelphia Chromosome mutation product, which have been associated with progressive atherosclerosis and acute vascular events. Additionally, agents designed to interfere with the vascular growth factor signaling pathway have vascular side effects ranging from hypertension to arterial events and cardiomyocyte toxicity. Interestingly, the risk of cardiotoxicity with drugs such as trastuzumab is predicted by preexisting cardiovascular risk factors and disease, posing the question of a vascular component to the pathophysiology. The effect on the coronary circulation has been the leading explanation for cardiotoxicity of 5-Fluorouracil and may be the underlying the mechanism of presentation of apical ballooning syndrome with various chemotherapeutics. Classical chemotherapeutics such as cisplatin, often used in combination with bleomycin and vinca alkaloids, can lead to vascular events including acute coronary thrombosis, may be associated with an increased long-term cardiovascular risk. This review is intended to provide an update on the evolving spectrum of vascular toxicities with cancer therapeutics, particularly as it pertains to clinical practice as well as the conceptualization of cardiovascular diseases. Vascular toxicity with cancer therapy: the old and the new, an evolving avenue. PMID:27022039

  10. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Black Rock Channel opposite foot..., DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.84 Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y. An area extending northwesterly between Black...

  11. EPA Finalizes $4 Million Cleanup Plan for Fulton Avenue Superfund Site in Hempstead and North Hempstead, N.Y.

    EPA Pesticide Factsheets

    (New York, N.Y.) The U.S. Environmental Protection Agency has finalized its decision to modify an interim cleanup plan originally issued in 2007 to address a portion of the contaminated groundwater at the Fulton Avenue Superfund site in the Towns of North

  12. 78 FR 19194 - P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... Bureau of Industry and Security P&P Computers, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying... Division, P&P Computers (``P&P'') was convicted of violating the International Emergency Economic Powers... IEEPA and the Iranian Transactions Regulations by exporting computer and related equipment from...

  13. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning at... of the westerly limit of the channel to a point approximately 360 feet southerly of Bird Island Pier... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Black Rock Channel opposite...

  14. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning at... of the westerly limit of the channel to a point approximately 360 feet southerly of Bird Island Pier... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Black Rock Channel opposite...

  15. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning at... of the westerly limit of the channel to a point approximately 360 feet southerly of Bird Island Pier... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Black Rock Channel opposite...

  16. 33 CFR 110.84 - Black Rock Channel opposite foot of Porter Avenue, Buffalo, N.Y.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Channel and Bird Island Pier opposite the foot of Porter Avenue, bounded as follows: Beginning at... of the westerly limit of the channel to a point approximately 360 feet southerly of Bird Island Pier... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Black Rock Channel opposite...

  17. 77 FR 74504 - Proposed Low-Effect Habitat Conservation Plan for the State-Route 99/Cartmill Avenue Interchange...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-14

    ... degradation that results in death or injury of listed species by significantly impairing essential behavioral... regulations as to carry out actions that create the likelihood of injury to listed species to such an extent... new Cartmill Avenue overpass would provide 16.5 feet of vertical clearance over State Route...

  18. 78 FR 19195 - RH International, LLC, 2531 West Maryland Avenue, Tampa, FL 33629, Respondent, Mohammad Reza (a/k...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ..., Respondent, Mohammad Reza (a/k/a Ray) Hajian, 2531 West Maryland Avenue, Tampa, FL 33629, Related Person.../a ``Ray'') Hajian (``Hajian'') is the owner and operator of RH International. Hajian pled guilty... the Regulations: Mohammad Reza (a/k/a ``Ray'') Hajian (``Hajian''), with a last known address at:...

  19. Viral ecology of organic and inorganic particles in aquatic systems: avenues for further research

    PubMed Central

    Weinbauer, M.G.; Bettarel, Y.; Cattaneo, R.; Luef, B.; Maier, C.; Motegi, C.; Peduzzi, P.; Mari, X.

    2016-01-01

    Viral abundance and processes in the water column and sediments are well studied for some systems; however, we know relatively little about virus–host interactions on particles and how particles influence these interactions. Here we review virus–prokaryote interactions on inorganic and organic particles in the water column. Profiting from recent methodological progress, we show that confocal laser scanning microscopy in combination with lectin and nucleic acid staining is one of the most powerful methods to visualize the distribution of viruses and their hosts on particles such as organic aggregates. Viral abundance on suspended matter ranges from 105 to 1011 ml−1. The main factors controlling viral abundance are the quality, size and age of aggregates and the exposure time of viruses to aggregates. Other factors such as water residence time likely act indirectly. Overall, aggregates appear to play a role of viral scavengers or reservoirs rather than viral factories. Adsorption of viruses to organic aggregates or inorganic particles can stimulate growth of the free-living prokaryotic community, e.g. by reducing viral lysis. Such mechanisms can affect microbial diversity, food web structure and biogeochemical cycles. Viral lysis of bacterio- and phytoplankton influences the formation and fate of aggregates and can, for example, result in a higher stability of algal flocs. Thus, viruses also influence carbon export; however, it is still not clear whether they short-circuit or prime the biological pump. Throughout this review, emphasis has been placed on defining general problems and knowledge gaps in virus–particle interactions and on providing avenues for further research, particularly those linked to global change. PMID:27478304

  20. Management of endocrine disease: Cystic fibrosis-related diabetes: novel pathogenic insights opening new therapeutic avenues.

    PubMed

    Barrio, Raquel

    2015-04-01

    Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR). CFTR is primarily present in epithelial cells of the airways, intestine and in cells with exocrine and endocrine functions. Mutations in the gene encoding the channel protein complex (CFTR) cause alterations in the ionic composition of secretions from the lung, gastrointestinal tract, liver, and also the pancreas. CF-related diabetes (CFRD), the most common complication of CF, has a major detrimental impact on pulmonary function, nutrition and survival. Glucose derangements in CF seem to start from early infancy and, even when the pathophysiology is multifactorial, insulin insufficiency is clearly a major component. Consistently, recent evidence has confirmed that CFTR is an important regulator of insulin secretion by islet β-cells. In addition, several other mechanisms were also recognized from cellular and animals models also contributing to either β-cell mass reduction or β-cell malfunction. Understanding such mechanisms is crucial for the development of the so-called 'transformational' therapies in CF, including the preservation of insulin secretion. Innovative therapeutic approaches aim to modify specific CFTR mutant proteins or positively modulate their function. CFTR modulators have recently shown in vitro capacity to enhance insulin secretion and thereby potential clinical utility in CFDR, including synergistic effects between corrector and potentiator drugs. The introduction of incretins and the optimization of exocrine pancreatic replacement complete the number of therapeutic options of CFRD besides early diagnosis and implementation of insulin therapy. This review focuses on the recently identified pathogenic mechanisms leading to CFRD relevant for the development of novel pharmacological avenues in CFRD therapy.

  1. Final Environmental Assessment for Gate 5 (Central Avenue) Interchange Improvements on F. E. Warren Air Force Base, Wyoming

    DTIC Science & Technology

    2012-04-01

    National Environmental Policy Act (NEPA), an Environmental Assessment (EA) has been developed to analyze potential environmental impacts associated with the...pursuant to the National Environmental Policy Act (Public Law 91-190, 42 U.S.C. 4321 et seq) and the Air Force Environmental Impact Process (32 CFR 898...at Gate 5 (Central Avenue) and add a visitor’s parking lot. 2. PURPOSE AND NEED FOR ACTION The purpose of this action is to provide safe access to

  2. Results of the independent radiological verification survey at 79 Avenue E, Lodi, New Jersey (LJ091V)

    SciTech Connect

    Rodriguez, R.E.; Uziel, M.S.

    1996-09-01

    Prior to remediation, thorium residues in excess of DOE applicable guidelines were found in the eastern comer of the backyard on property at 79 Avenue B, Lodi, New Jersey. Decontamination, which consisted of excavation and removal of contaminated soil, was performed by subcontractors under the direction of Bechtel National, Inc. The independent radiological verification survey described in this report was performed by the Measurement Applications and Development Group at Oak Ridge National Laboratory to verify that the final remedial action had reduced contamination levels to within authorized limits. The property at 79 Avenue B, Lodi, New Jersey, was thoroughly investigated outdoors for radionuclide residues. Surface gamma exposure rates were below guideline levels and comparable the area. The results of soil radionuclide analysis for all soil concentration measurements were below limits prescribed by DOE applicable guidelines for protection against radiation. Analysis of data contained in the post-remedial action report and results of this independent radiological verification survey by ORNL confirm that all radiological measurements fall below the limits prescribed by DOE guidelines established for this site. The property at 79 Avenue B successfully meets the DOE remedial action objectives.

  3. Avenues and barriers to access of services for immigrant elders: state and local policies for OAA units on aging.

    PubMed

    Okafor, Maria C

    2009-07-01

    The diversification and aging of the US population has been at the root of many political and policy debates in recent years. Of particular interest has been the place of immigrants in an aging society, and what rights these immigrants are entitled to. The objective of this article is to describe the current avenues and barriers to access of services for immigrant elders and examine potential solutions for reform. The article begins with a historical overview of the policy issue, followed by the current status of the issue in the United States and suggestions for reform.

  4. 75 FR 34347 - Airworthiness Directives; Honeywell International Inc. Auxiliary Power Unit Models GTCP36-150(R...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... erosion, replacing the FCU if it fails the inspection, and installing a fuel deflector on the Delta P... to require inspecting the Delta P sleeve bore for erosion, replacing the FCU if it fails the... Differential Pressure (Delta P) Sleeve Bore (f) Inspect the FCU Delta P sleeve bore for erosion. Use...

  5. The Potential of GIS as a Management Tool for Avenue Trees Population in Small Communities; a Case Study of Idi-Shin Community, Ibadan, Nigeria

    NASA Astrophysics Data System (ADS)

    Olokeogun, O. S.; Akintola, O. O.; Abodunrin, E. K.

    2016-06-01

    This study demonstrates the potentials of Geographic Information System (GIS) as a management tool for avenue trees (Street trees) populations in small communities (using Idi-Ishin community, Ibadan, Nigeria as a case study). GIS is a decision support system which integrate data or set of data from different sources, bringing them under the same referencing system in a computer system. An Ikonos Imagery (1m Spatial Resolution) of the study area was digitized to produce a digital map using ArcGIS 10.1 version. The avenue trees species ≥ 5cm diameter at breast height (DBH) was selected for enumeration. These trees were then measured and tagged. The Height, Girth and Geographic location (X &Y coordinate) of the trees were measured with Haga altimeter, Girthing tape and Hand held Global Positioning System (GPS) respectively. The species and families of the trees enumerated were also identified. Data were analysed for basal area (BA) and volume (V). A total number of 43 avenue trees were assessed in Idi-Ishin Community. Roystonea regia accounted for the majority of the avenue trees (25.58%), followed by Polyanthia longiflora (23.26%), Gliricida seprium (20.93%), Eucalyptus toreliana (13.95%), Delunix regea (6.98%). However Terminalia catapa, Terminalia radii, Azadrachita indica and Newbodia levis had the same abundance of 2.33%. It was also observed that the benefits derived from these avenue trees includes; Carbon sequestration, Beautification, Wind break and shade. A spatial relational database was created for the assessed avenue trees using ArcCatalog of ArcGIS 10.1 version. Based on the findings from the study (which serves as baseline information for the management of the avenue trees in the study area), it was therefore recommended that subsequent assessment should be carried out at 3-5 year interval in other to ensure proper and continuous monitoring and updating of the data.

  6. Avenues to Inspiration

    ERIC Educational Resources Information Center

    Campbell, Ashley

    2011-01-01

    Integrating the worlds of art and science can be a perfect tool for engaging students who wouldn't be initially interested in a science class. Even those students who love science may delve deeper into the subject when it's associated with art. One way to make this connection is to explore the life and work of great nature artists of the past and…

  7. Influence of avenue-trees on air quality at the urban neighborhood scale. Part I: quality assurance studies and turbulent Schmidt number analysis for RANS CFD simulations.

    PubMed

    Gromke, Christof; Blocken, Bert

    2015-01-01

    Flow and dispersion of traffic pollutants in a generic urban neighborhood with avenue-trees were investigated with Computational Fluid Dynamics (CFD). In Part I of this two-part contribution, quality assessment and assurance for CFD simulations in urban and vegetation configurations were addressed,before in Part II flow and dispersion in a generic urban neighborhood with multiple layouts of avenue trees were studied. In a first step, a grid sensitivity study was performed that inferred that a cell count of 20 per building height and 12 per canyon width is sufficient for reasonable grid insensitive solutions. Next, the performance of the realizable k-ε turbulence model in simulating urban flows and of the applied vegetation model in simulating flow and turbulence in trees was validated. Finally, based on simulations of street canyons with and without avenue-trees, an appropriate turbulent Schmidt number or modeling dispersion in the urban neighborhood was determined as Sc(t) =0.5.

  8. The compensatory renin-angiotensin system in the central regulation of arterial pressure: new avenues and new challenges.

    PubMed

    Mendoza, Alberto; Lazartigues, Eric

    2015-08-01

    Hypertension is a widespread condition that affects millions of people around the world and has a major impact in public health. The classic renin-angiotensin system is a complex system comprised of multiple peptides and pathways that have been the driver of drug development over the years to control hypertension. However, there are still patients whose hypertension is very difficult to control with current drugs and strategies, thus motivating further research in this field. In the past two decades, important discoveries have expanded our knowledge of this system and new pathways are emerging that are helping us understand the complex interaction taking place not only in the periphery, but also in the central nervous system where the renin-angiotensin system is also very active. A new arm, called the ACE2/Ang-(1-7)/Mas receptor axis, was shown to exert antihypertensive properties and serve as a counterbalance to the classic ACE/angiotensin II/AT1 receptor axis, in this way modulating or even counteracting the negative effects of angiotensin II in blood pressure regulation and water retention. Modulation of this new axis through ACE2 activation, ADAM17 regulation or AT1 receptor internalization are some of the novel avenues and challenges that have the potential to become a target for new drug research and development for the treatment of hypertension.

  9. Radiological assessment and remedial action report for the ''Son of Lansdowne'' property, 186 North Lansdowne Avenue, Lansdowne, Pennsylvania

    SciTech Connect

    Smith, W.H.; Wynveen, R.A.

    1987-08-01

    This document reports the results of a radiological assessment and remedial action program conducted by Argonne National Laboratory personnel at a radioactively contaminated private residence in Lansdowne, Pennsylvania. The program was conducted on the residence at 186 Lansdowne Avenue. The survey conducted by the ANL personnel indicated that several dozen areas or spots of contamination were present on all floors and the basement of the three-story house. Contamination was found on furniture, carpeting, walls, floors, woodwork, and ceilings. Remedial action undertaken to remove the contamination ranged from scrubbing, to scraping, to shaving of wood, to removal and disposal of items and material that could not be adequately decontaminated. Outdoors, contaminated soil was removed from the backyard, and the driveway was dug up so the contaminated subsurface material could be removed. The remedial action generated quantities of radioactive waste, including four 55-gallon drums and one M-III bin (120 ft/sup 3/) containing floor tile, concrete, personal items, furniture, floor scrapings, vermiculite absorbed scrub water, and other items. In addition, there were 24 M-III bins containing approximately 112 tons of contaminated soil and rock from the two contaminated areas in the backyard and from the contaminated subsurface of the driveway. 2 refs., 39 figs., 12 tabs.

  10. A new avenue for obtaining insight into the functional characteristics of long noncoding RNAs associated with estrogen receptor signaling

    PubMed Central

    Wu, Liangcai; Xu, Qianqian; Zhang, Haohai; Li, Ming; Zhu, Chengpei; Jiang, Minjie; Sang, Xinting; Zhao, Yi; Sun, Qiang; Zhao, Haitao

    2016-01-01

    Estrogen receptor signalling plays important regulatory roles in multiple mammalian physiological processes. Dysregulation of estrogen receptor (ER) expression and/or its associated signalling pathway is strongly associated with the development, progression, transition, and endocrine-resistance of breast cancer. Non-coding transcripts are essential regulators of almost every level of gene regulation. However, few long non-coding transcripts (lncRNAs) associated with the estrogen receptor signalling pathway have been well-described. We used array-based methods to identify 33 estrogen receptor agitation-related (ERAR) lncRNAs. A coding–non-coding gene co-expression network analysis suggested that 15 ERAR lncRNAs were associated with mitosis, DNA damage, and DNA repair. Kaplan–Meier analysis indicated that five ERAR lncRNAs selected using the Random Forest-Recursive Feature Elimination algorithm were significantly correlated with endocrine resistance-free survival and distant metastasis-free survival as well as disease free survival. Our results suggest that ERAR lncRNAs may serve as novel biomarkers for guiding breast cancer treatment and prognosis. Furthermore, our findings reveal a new avenue by which estrogen receptor signalling can be further explored. PMID:27539025

  11. Public health assessment for Plymouth Avenue Landfill, Deland, Volusia County, Florida, Region 4. Cerclis No. FLD984167569. Final report

    SciTech Connect

    Not Available

    1994-08-24

    The Plymouth Avenue Landfill is about 1.75 miles west of the City of DeLand in rural western Volusia County, Florida. From 1971 to 1988 it was a Class I landfill and received all types of nonhazardous industrial and municipal solid waste. From June 1978 to October 1980, the landfill reportedly received 4,500 gallons per week of process waste slurry from the Brunswick Corporation. The authors selected the following contaminants of concern: barium, chromium, 1,2-dichloroethene, iron, nitrate, sulfate, and vinyl chloride. Ingestion of ground water is a past completed human exposure pathway. Concentrations of the contaminants of concern found so far are unlikely to have caused illness in the nearby residents. Analysis of water samples has been inadequate, however, to assess the public health threat from ingestion of sulfate, giardia, or vinyl chloride. Based on the information currently available, the authors classify the public health hazard at this landfill as indeterminate. Groundwater sampling is needed to determine the extent of vinyl chloride contamination.

  12. EPA Encourages the Public to Comment on Revisions to Cleanup Plan for Fulton Avenue Superfund Site in Nassau County, New York

    EPA Pesticide Factsheets

    (New York, N.Y. - April 24, 2015) The U.S. Environmental Protection Agency is proposing to modify an interim cleanup plan originally issued in 2007 to address a portion of the contaminated groundwater at the Fulton Avenue Superfund site in the Towns of Nor

  13. 77 FR 27082 - StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc., 1250 H Street, Greeley, CO...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-08

    ... Employment and Training Administration StarTek USA, Inc., 244 Dundee Avenue, Greeley, CO; StarTek USA, Inc... December 28, 2010, applicable to workers and former workers of StarTek USA, Inc., Greeley, Colorado. The... reviewed the certification for workers of the subject firm. New information shows that there are two...

  14. Effects of distance from a heavily transited avenue on asthma and atopy in a peri-urban shanty-town in Lima, Peru

    PubMed Central

    Baumann, Lauren M; Robinson, Colin L; Combe, Juan M; Gomez, Alfonso; Romero, Karina; Gilman, Robert H; Cabrera, Lilia; Hansel, Nadia N; Wise, Robert A; Breysse, Patrick N; Barnes, Kathleen; Hernandez, Juan E; Checkley, William

    2011-01-01

    Background Proximity to roadways increases the risk of asthma in developed countries; however, relatively little is known about this relationship in developing countries, where rapid and uncontrolled growth of cities has resulted in urban sprawl and heavy traffic volumes. Objective Determine the effect of distance from a heavily transited avenue on asthma symptoms and quantitative respiratory outcome measures in a peri-urban shanty town in Lima, Peru. Methods We enrolled 725 adolescents aged 13–15 years, administered a survey on asthma symptoms and measured spirometry, response to allergy skin testing and eNO. We calculated distances from the main avenue for all households and measured indoor PM in 100 households. We used multivariable regression to model the risk of asthma symptoms, risk of atopy, eNO and FEV1/FVC as a function of distance. Results Compared against 384 meters, the odds of current asthma symptoms in households living within 100 meters increased by a factor of 2 (p<0.05). The odds of atopy increased by a factor of 1.07 for every 100 meters difference in the distance from the avenue (p=0.03). We found an inverse relationship in pre-bronchodilator FEV1/FVC and distance to the avenue in females (p=0.01) but not in males. We did not find an association between eNO or household PM levels and distance. Conclusion Living in close proximity to a high traffic-density avenue in a peri-urban community in Peru was associated with a greater risk of asthma symptoms and atopy. Regulation of mobile source pollutants in peri-urban areas of developing countries may help reduce the burden of asthma symptoms and atopy. PMID:21237505

  15. Influence of avenue-trees on air quality at the urban neighborhood scale. Part II: traffic pollutant concentrations at pedestrian level.

    PubMed

    Gromke, Christof; Blocken, Bert

    2015-01-01

    Flow and dispersion of traffic-emitted pollutants were studied in a generic urban neighborhood for various avenue-tree layouts by employing 3D steady RANS simulations with the realizable k-ε turbulence model. In comparison to the tree-free situation quantitative and qualitative changes with flow reversal in the wind field were observed. Low to moderate increases (<13.2%) in the neighborhood-averaged pollutant concentration were found at pedestrian level. An approximately 1% increase in the neighborhood-averaged concentration was obtained with each percent of the street canyon volumes being occupied by vegetation for occupation fractions between 4 and 14%. The overall pattern of concentration changes relative to the tree-free situation was similar for all avenue-tree layouts. However, pronounced locally restricted decreases or increases in concentration (-87 to +1378%) occurred. The results indicate the necessity to account for existing or planned avenue-trees in neighborhood scaled is dispersion studies. Their consideration is prerequisite for reliable urban air quality assessment.

  16. Superfund Record of Decision (EPA Region 2): Mannheim Avenue Dump site, Galloway Township, Atlantic County, NJ. (First remedial action), September 1990. Final report

    SciTech Connect

    Not Available

    1990-09-27

    The 2-acre Mannheim Avenue Dump site is a former municipally-owned industrial waste landfill in Galloway Township, Atlantic County, New Jersey. Surrounding land use is rural residential, and many residents and facilities in the area use ground water as their drinking water supply. Beginning in 1964, drummed industrial wastes, including TCE degreasing sludge, leaded porcelain fragments, and municipal waste, were buried onsite in 35 waste mounds. In 1982, a State survey indicated the presence of many unburied and leaking drums onsite. Sampling from 1985 to 1986, revealed ground water contamination onsite. In 1989, 35 mounds of contaminated soil were disposed of offsite. The Record of Decision (ROD) addresses ground water contamination at the site. The primary contaminants of concern affecting the ground water are VOCs including benzene and TCE.

  17. Acacia Avenue and Coronation Street

    ERIC Educational Resources Information Center

    Rees, Christopher; Edmunds, Philip Turnbull

    1971-01-01

    Summarizes some of the more significant findings from a survey of two socially and economically disparate areas in Nottinghamshire, and calls for a less limited approach to university adult education in Britain. (Editor/AN)

  18. Madison Avenue vs. the Environmentalists

    ERIC Educational Resources Information Center

    Sandman, Peter M.

    1973-01-01

    The Chevron F-310 advertising program is studied as an example of large companies' use of environmental and conservation themes for attracting customers. The effects of such advertising on the society are discussed. (JP)

  19. Black Television: Avenue of Power

    ERIC Educational Resources Information Center

    Douglas, Pamela

    1973-01-01

    Analyzes a few of the prominent issues in black television, examining public television, commercial television, black ownership of stations, cable television, and some projections for the future. (Author/JM)

  20. miR-199a-3p inhibits aurora kinase A and attenuates prostate cancer growth: new avenue for prostate cancer treatment.

    PubMed

    Qu, Yi; Huang, Xiang; Li, Zhiqing; Liu, Junyan; Wu, Jinlin; Chen, Dapeng; Zhao, Fengyan; Mu, Dezhi

    2014-05-01

    Prostate cancer (PCa) is the most common solid tumor malignancy in men that severely influences quality of life. Surgery is most often the recommended treatment for PCa, but radical prostatectomy can cause significant urinary adverse effects. Therefore, finding effective biochemical treatments for PCa remains a necessity. Aurora kinase A has been shown to be involved in PCa progression, thus making it a good target for PCa therapy. miRNAs are important regulators of gene expression, with some miRNAs specifically involved in carcinogenesis. Therefore, herein, we identified miRNAs targeted to aurora kinase A and examined their effects on the growth of PCa. We used primary samples from PCa patients and PCa cell lines as research subjects. We demonstrate that miR-199a-3p is down-regulated in PCa tissues compared with normal prostate tissues, with the expression pattern inversely correlated with the expression pattern of aurora kinase A. We find that miR-199a-3p agomir inhibits aurora kinase A and attenuates xenograft tumor growth of PCa. Moreover, we demonstrate that down-regulation of miR-199a-3p results from enhancement of the methylation of miR-199a gene in PCa. Furthermore, we find that the expression level of miR-199a-3p is inversely correlated to tumor stage and Gleason score of PCa. Revealing novel mechanisms for oncogene inhibition by miRNA-mediated pathways offers new avenues for PCa treatment.

  1. Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for a Disease Modifying Treatment of Alzheimer’s?

    PubMed Central

    2012-01-01

    With 24.3 million people affected in 2005 and an estimated rise to 42.3 million in 2020, dementia is currently a leading unmet medical need and costly burden on public health. Seventy percent of these cases have been attributed to Alzheimer’s disease (AD), a neurodegenerative pathology whose most evident symptom is a progressive decline in cognitive functions. Dual specificity tyrosine phosphorylation regulated kinase-1A (DYRK1A) is important in neuronal development and plays a variety of functional roles within the adult central nervous system. The DYRK1A gene is located within the Down syndrome critical region (DSCR) on human chromosome 21 and current research suggests that overexpression of DYRK1A may be a significant factor leading to cognitive deficits in people with Alzheimer’s disease (AD) and Down syndrome (DS). Currently, treatment options for cognitive deficiencies associated with Down syndrome, as well as Alzheimer’s disease, are extremely limited and represent a major unmet therapeutic need. Small molecule inhibition of DYRK1A activity in the brain may provide an avenue for pharmaceutical intervention of mental impairment associated with AD and other neurodegenerative diseases. We herein review the current state of the art in the development of DYRK1A inhibitors. PMID:23173067

  2. Three-dimensional visualization maps of suspended-sediment concentrations during placement of dredged material in 21st Avenue West Channel Embayment, Duluth-Superior Harbor, Duluth, Minnesota, 2015

    USGS Publications Warehouse

    Groten, Joel T.; Ellison, Christopher A.; Mahoney, Mollie H.

    2016-06-30

    Excess sediment in rivers and estuaries poses serious environmental and economic challenges. The U.S. Army Corps of Engineers (USACE) routinely dredges sediment in Federal navigation channels to maintain commercial shipping operations. The USACE initiated a 3-year pilot project in 2013 to use navigation channel dredged material to aid in restoration of shoreline habitat in the 21st Avenue West Channel Embayment of the Duluth-Superior Harbor. Placing dredged material in the 21st Avenue West Channel Embayment supports the restoration of shallow bay aquatic habitat aiding in the delisting of the St. Louis River Estuary Area of Concern.The U.S. Geological Survey, in cooperation with the USACE, collected turbidity and suspended-sediment concentrations (SSCs) in 2014 and 2015 to measure the horizontal and vertical distribution of SSCs during placement operations of dredged materials. These data were collected to help the USACE evaluate the use of several best management practices, including various dredge material placement techniques and a silt curtain, to mitigate the dispersion of suspended sediment.Three-dimensional visualization maps are a valuable tool for assessing the spatial displacement of SSCs. Data collection was designed to coincide with four dredged placement configurations that included periods with and without a silt curtain as well as before and after placement of dredged materials. Approximately 230 SSC samples and corresponding turbidity values collected in 2014 and 2015 were used to develop a simple linear regression model between SSC and turbidity. Using the simple linear regression model, SSCs were estimated for approximately 3,000 turbidity values at approximately 100 sampling sites in the 21st Avenue West Channel Embayment of the Duluth-Superior Harbor. The estimated SSCs served as input for development of 12 three-dimensional visualization maps.

  3. Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health, and Functioning.

    PubMed

    Fung, Constance H; Vitiello, Michael V; Alessi, Cathy A; Kuchel, George A

    2016-12-01

    The American Geriatrics Society, with support from the National Institute on Aging and other funders, held its eighth Bedside-to-Bench research conference, entitled "Sleep, Circadian Rhythms, and Aging: New Avenues for Improving Brain Health, Physical Health and Functioning," October 4 to 6, 2015, in Bethesda, Maryland. Part of a conference series addressing three common geriatric syndromes-delirium, sleep and circadian rhythm (SCR) disturbance, and voiding dysfunction-the series highlighted relationships and pertinent clinical and pathophysiological commonalities between these three geriatric syndromes. The conference provided a forum for discussing current sleep, circadian rhythm, and aging research; identifying gaps in knowledge; and developing a research agenda to inform future investigative efforts. The conference also promoted networking among developing researchers, leaders in the field of SCR and aging, and National Institutes of Health program personnel.

  4. Charter Schools: An Avenue to Quality Education.

    ERIC Educational Resources Information Center

    Uerling, Donald F.; Dlugosh, Larry L.

    During the 1990s, the charter-school movement emerged as one of the more promising new ideas in education. This paper juxtaposes the charter-school concept with ideas on change theory and curriculum design. The article's purpose is to illustrate how charter schools might be a vehicle for change in education. Research shows that states have enacted…

  5. A Grand Avenue to Au Nanocluster Electrochemiluminescence.

    PubMed

    Hesari, Mahdi; Ding, Zhifeng

    2017-02-21

    In most cases of semiconductor quantum dot nanocrystals, the inherent optical and electrochemical properties of these interesting nanomaterials do not translate into expected efficient electrochemiluminescence or electrogenerated chemiluminescence (ECL) because of the surface-state induction effect. Thus, their low ECL efficiencies, while very interesting to explore, limit their applications. As their electrochemistry is not well-defined, insight into their ECL mechanistic details is also limited. Alternatively, gold nanoclusters possess monodispersed sizes with atomic precision, low and well defined HOMO-LUMO energy gaps, and stable optical and electrochemical properties that make them suitable for potential ECL applications. In this Account, we demonstrate strong and sustainable ECL of gold nanoclusters Au25(z) (i.e., Au25(SR)18(z), z = 1-, 0, 1+), Au38(SR)24, and Au144(SR)60, where the ligand SR is 2-phenylethanethiol. By correlation of the optical and electrochemical features of Au25 nanoclusters, a Latimer-type diagram can be constructed to reveal thermodynamic relationships of five oxidation states (Au25(2+), Au25(+), Au25(0), Au25(-), and Au25(2-)) and three excited states (Au25(-)*, Au25(0)*, and Au25(+)*). We describe ECL mechanisms and reaction kinetics by means of conventional ECL-voltage curves and novel spooling ECL spectroscopy. Notably, their ECL in the presence of tri-n-propylamine (TPrA), as a coreactant, is attributed to emissions from Au25(-)* (950 nm, strong), Au25(0)* (890 nm, very strong), and Au25(+)* (890 nm, very strong), as confirmed by the photoluminescence (PL) spectra of the three Au25 clusters electrogenerated in situ. The ECL emissions are controllable by adjustment of the concentrations of TPrA· and Au25(-), Au25(0), and Au25(+) species in the vicinity of the working electrode and ultimately the applied potential. It was determined that the Au25(-)/TPrA coreactant system should have an ECL efficiency of >50% relative to the Ru(bpy)3(2+)/TPrA, while those of Au25(0)/TPrA and Au25(+)/TPrA reach 103% and 116%, respectively. Au25(-)* is the main light emission source for Au25(z) in the presence of benzoyl peroxide (BPO) as a coreactant, with a relative efficiency of up to 30%. For Au38, BPO leads to the Au38(-)* excited state, which emits light at 930 nm. In the Au38/TPrA coreactant system, we find that highly efficient light emission at 930 nm is mainly from Au38(+)* (and also Au38(3+)*), with an efficiency 3.5 times that of the Ru(bpy)3(2+)/TPrA reference. We show that the ECL and PL of the various Au38 charge states, namely, Au38(2-), Au38(-), Au38(0), Au38(+), Au38(2+), and Au38(4+), have the same peak wavelength of 930 nm. Finally, we demonstrate ECL with a peak wavelength of 930 nm from the Au144/TPrA coreactant system, which is released from the electrogenerated excited states Au144(+)* and Au144(3+)*. In our opinion, these gold nanoclusters represent a new class of effective near-IR ECL emitters, from which applications such as bioimaging, biological testing, and medical diagnosis are anticipated once they are made water-dispersible with hydrophilic capping ligands.

  6. Creating New Avenues for CTE Teacher Development.

    ERIC Educational Resources Information Center

    Szuminski, Kathleen A.

    2002-01-01

    A model program for onsite teacher development to prepare and retain exemplary career and technical education teachers was designed to meet the needs of new teachers who came from industry backgrounds. Core elements include partnership with business- industry and universities and ongoing support for teaching strategies. (JOW)

  7. Varroa destructor: research avenues towards sustainable control

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Pollination by honeybees plays a key role in the functioning of ecosystems and optimization of agricultural yields. Severe honeybee colony losses worldwide have raised concerns about the sustainability of these pollination services. In most cases, bee morbidity appears to be the product of many inte...

  8. Avenues of Influence: Cross-Cultural Implications

    DTIC Science & Technology

    2014-04-01

    DoD) Intelligence, Surveillance, and Reconnaissance (ISR) community with knowledge of mechanisms that explain why some factors can be influentially...supports the Intelligence Community (IC) efforts to understand, forecast, and influence actor behavior. The growing importance of behavioral influences...This in-house effort leveraged multiple resources: Established professional relationships within the international military research community

  9. Cardiac Lymphatics - A New Avenue for Therapeutics?

    PubMed

    Vuorio, Taina; Tirronen, Annakaisa; Ylä-Herttuala, Seppo

    2017-01-10

    Recent progress in lymphatic vessel biology and in novel imaging techniques has established the importance of the lymphatic vasculature as part of the cardiovascular system. The lymphatic vessel network regulates many physiological processes important for heart function such as fluid balance, transport of extravasated proteins, and trafficking of immune cells. Therefore, lymphangiogenic therapy could be beneficial in the treatment of cardiovascular diseases, for example by improving reverse cholesterol transport (RCT) from atherosclerotic lesions or by resolving edema and fibrosis after myocardial infarction. In this review we first describe recent findings on the development and function of cardiac lymphatic vessels, and subsequently focus on the prospects of pro- and anti-lymphangiogenic therapies in cardiovascular diseases.

  10. Spontaneous Play: An Avenue for Intellectual Development.

    ERIC Educational Resources Information Center

    Almy, Millie

    1966-01-01

    It is generally conceded that there is much for a child to learn while attending nursery school, but the teacher is often unsure as to what type of curriculum or program will best assure such learning. Specifically, although play has been part of all nursery school programs, it is questioned whether spontaneous play (that is, relatively…

  11. Probiotics in shrimp aquaculture: avenues and challenges.

    PubMed

    Ninawe, A S; Selvin, Joseph

    2009-01-01

    As an alternative strategy to antibiotic use in aquatic disease management, probiotics have recently attracted extensive attention in aquaculture. However, the use of terrestrial bacterial species as probiotics for aquaculture has had limited success, as bacterial strain characteristics are dependent upon the environment in which they thrive. Therefore, isolating potential probiotic bacteria from the marine environment in which they grow optimally is a better approach. Bacteria that have been used successfully as probiotics belong to the genus Vibrio and Bacillus, and the species Thalassobacter utilis. Most researchers have isolated these probiotic strains from shrimp culture water, or from the intestine of different penaeid species. The use of probiotic bacteria, based on the principle of competitive exclusion, and the use of immunostimulants are two of the most promising preventive methods developed in the fight against diseases during the last few years. It also noticed that probiotic bacteria could produce some digestive enzymes, which might improve the digestion of shrimp, thus enhancing the ability of stress resistance and health of the shrimp. However, the probiotics in aquatic environment remain to be a controversial concept, as there was no authentic evidence / real environment demonstrations on the successful use of probiotics and their mechanisms of action in vivo. The present review highlights the potential sources of probiotics, mechanism of action, diversity of probiotic microbes and challenges of probiotic usage in shrimp aquaculture.

  12. Pharmaceutical technology management--profitable business avenue.

    PubMed

    Puthli, Shivanand P

    2010-01-01

    Growing research expenditure, regulatory framework and generic erosion have forced pharmaceutical companies globally to resort to pharmaceutical technology management (PTM). Indeed, the pharmaceutical industry has witnessed the impact of innovative drug delivery and device technologies and their influence on business. PTM has given a new business insight with greater profits and enhancement of product franchise. Promising breakthrough technologies have not been able to reach a commercial platform largely owing to lack of capital at the preliminary stages of the product development program. Intellectual property plays a considerable role in protecting innovative technologies. Joint ventures and strategic alliances also become important for commercializing a new technology. The synergy of PTM with options of in-licensing is expected to infuse newer opportunities to the pharmaceutical business.

  13. Varroa destructor: research avenues towards sustainable control

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A recent review article about sustainable control of Varroa mites implies that little progress has been made in developing and applying honey bees that have genetic resistance to mites. Here we explain some of the successes that have resulted from research into genetic resistance In sum, we suggest ...

  14. Additional insights. Commentary on “the musical stroop effect: opening a new avenue to research on automatisms” by l. Grégoire, P. Perruchet, and B. Poulin-Charronnat (Experimental Psychology, 2013, vol. 60, pp. 269–278).

    PubMed

    Akiva-Kabiri, Lilach; Henik, Avishai

    2014-01-01

    In their paper "The Musical Stroop Effect: Opening a New Avenue to Research on Automatisms," Grégoire, Perruchet, and Poulin-Charronnat (2013) use a musical Stroop-like task to demonstrate the automaticity of musical note naming in musicians. In addition, the authors suggest that music training can serve as a tool in order to study the acquisition of automaticity. In the following commentary, we aim to address three main issues concerning the paper by Grégoire et al. (2013). First, we will suggest some additional interpretations of the results; specifically, we will relate to the association between music and space. Second, we will discuss a methodological issue dealing with interference, facilitation, and the role of the neutral condition. We suggest that the study by Grégoire et al. (2013) lacks a proper neutral condition and thus it is impossible to assert that the congruency effect is interference based. Third, we will discuss the authors' suggestion of using the musical Stroop effect as a tool for studying automatism. We consider the practical relevance of music training as a tool for studying the acquisition of automaticity by pointing out that music training is highly heterogeneous.

  15. The California fuel cell partnership: an avenue to clean air

    NASA Astrophysics Data System (ADS)

    Lloyd, Alan C.

    The California Fuel Cell Partnership presently consists of eight private companies, two state agencies and a federal government representative that will attempt to demonstrate the feasibility of fuel cell cars and buses. California has attempted to advance the commercialization of zero-emission vehicles for much of the past decade to help the state reduce its high levels of air pollution. A special advisory panel convened by the California Air Resources Board concluded last year that fuel cell technology could meet the key requirements for automobiles. The successful commercialization of fuel cell vehicles would help to reduce the levels of ozone, fine particles and toxic air contaminants that pose health risks to California's population. This technology can also help to reduce carbon dioxide emissions. California regulations now encourage the development of zero and near-zero emission vehicle technologies, including fuel cells. The Fuel Cell Partnership will operate approximately 50 fuel cell cars and buses until the year 2003 in order to produce important information on the vehicles and fueling infrastructure needed to support them.

  16. New avenues for phase matching in nonlinear hyperbolic metamaterials.

    PubMed

    Duncan, C; Perret, L; Palomba, S; Lapine, M; Kuhlmey, B T; de Sterke, C Martijn

    2015-03-11

    Nonlinear optical processes, which are of paramount importance in science and technology, involve the generation of new frequencies. This requires phase matching to avoid that light generated at different positions interferes destructively. Of the two original approaches to achieve this, one relies on birefringence in optical crystals, and is therefore limited by the dispersion of naturally occurring materials, whereas the other, quasi-phase-matching, requires direct modulation of material properties, which is not universally possible. To overcome these limitations, we propose to exploit the unique dispersion afforded by hyperbolic metamaterials, where the refractive index can be arbitrarily large. We systematically analyse the ensuing opportunities and demonstrate that hyperbolic phase matching can be achieved with a wide range of material parameters, offering access to the use of nonlinear media for which phase matching cannot be achieved by other means. With the rapid development in the fabrication of hyperbolic metamaterials, our approach is destined to bring significant advantages over conventional techniques for the phase matching of a variety of nonlinear processes.

  17. Vulnerability and Gambling Addiction: Psychosocial Benchmarks and Avenues for Intervention

    ERIC Educational Resources Information Center

    Suissa, Amnon Jacob

    2011-01-01

    Defined by researchers as "a silent epidemic" the gambling phenomenon is a social problem that has a negative impact on individuals, families and communities. Among these effects, there is exasperating evidence of comprised community networks, a deterioration of family and social ties, psychiatric co-morbidity, suicides and more recently,…

  18. Computers: New Avenues for Engineering Students at the Community College.

    ERIC Educational Resources Information Center

    Brillhart, Lia; Shawhan, Douglas

    At Triton College, student involvement with computers as a continued, multifaceted process is considered a primary objective of the physics and engineering department. To that end, the department implemented a low cost diverse program. The computer uses presented include labs, algorithms, testing, individual projects, drills, graphics, simulation,…

  19. Avenue T: Using Film as "Entree" in Teaching about Transgender

    ERIC Educational Resources Information Center

    Walters, Andrew S.; Rehma, Kae

    2013-01-01

    Educators from a variety of disciplines include the concept of transgender and multiple gender identities in course curricula. The "T" (denoting the specific inclusion of transgender) in the popular acronym LGBT (lesbian, gay, bisexual, transgender) often is given less pedagogical attention than is sexual orientation, and the transgender…

  20. Does MAX open up a new avenue for meiotic research?

    PubMed

    Suzuki, Ayumu; Hirasaki, Masataka; Okuda, Akihiko

    2017-02-01

    Meiosis is a central event of sexual reproduction. Like somatic cells, germ cells conduct mitosis to increase their cell number, but unlike somatic cells, germ cells switch their cell division mode from mitosis to meiosis at a certain point in gametogenesis. However, the molecular basis of this switch remains elusive. In this review article, we give an overview of the onset of mammalian meiosis, including our recent finding that MYC Associated Factor X (MAX) prevents ectopic and precocious meiosis in embryonic stem cells (ESCs) and germ cells, respectively. We present a hypothetical model of a MAX-centered molecular network that regulates meiotic entry in mammals and propose that inducible Max knockout ESCs provide an excellent platform for exploring the molecular mechanisms of meiosis initiation, while excluding other aspects of gametogenesis.

  1. DOE ZERH Case Study: Sunroc Builders, Bates Avenue, Lakeland, FL

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning affordable home in the hot-humid climate that got HERS 57 without PV, with 6.5” SIP walls and 8.25” SIP roof; uninsulated slab foundation; fresh air intake; SEER 16 ducted air source heat pump.

  2. New avenues for matter-wave-enhanced spectroscopy

    NASA Astrophysics Data System (ADS)

    Rodewald, Jonas; Haslinger, Philipp; Dörre, Nadine; Stickler, Benjamin A.; Shayeghi, Armin; Hornberger, Klaus; Arndt, Markus

    2017-01-01

    We present matter-wave interferometry as a tool to advance spectroscopy for a wide class of nanoparticles, clusters and molecules. The high sensitivity of de Broglie interference fringes to external perturbations enables measurements in the limit of an individual particle absorbing only a single photon on average, or even no photon at all. The method allows one to extract structural and electronic information from the loss of the interference contrast. It is minimally invasive and works even for dilute ensembles.

  3. Gold-Catalyzed Cyclization Processes: Pivotal Avenues for Organic Synthesis.

    PubMed

    Kumar, Amit; Singh, Sukhdev; Sharma, Sunil K; Parmar, Virinder S; Van der Eycken, Erik V

    2016-02-01

    Over the years, gold catalysis has materialized as an incredible synthetic approach among the scientific community. Due to the trivial reaction conditions and great functional compatibility, these progressions are synthetically expedient, because practitioners can implement them to build intricate architectures from readily amassed building blocks with high bond forming indices. The incendiary growth of gold catalysts in organic synthesis has been demonstrated as one of the most prevailing soft Lewis acids for electrophilic activation of carbon-carbon multiple bonds towards a great assortment of nucleophiles. Nowadays, organic chemists consistently employ gold catalysts to carry out a diverse array of organic transformations to build unprecedented molecular architectures. Despite all these achievements and a plethora of reports, many vital challenges remain. In this account, we describe the reactivity of various gold catalysts towards cyclization processes developed over the years. These protocols give access to a wide scope of polyheterocyclic structures, containing different medium-sized ring skeletons. This is interesting, as the quest for highly selective reactions to assemble diversely functionalized products has attracted much attention. We envisage that these newly developed chemo-, regio-, and diastereoselective protocols could provide an expedient route to architecturally cumbersome heterocycles of importance for the pharmaceutical industry.

  4. Imaging techniques: new avenues in cancer gene and cell therapy.

    PubMed

    Saadatpour, Z; Rezaei, A; Ebrahimnejad, H; Baghaei, B; Bjorklund, G; Chartrand, M; Sahebkar, A; Morovati, H; Mirzaei, H R; Mirzaei, H

    2017-01-01

    Cancer is one of the world's most concerning health problems and poses many challenges in the range of approaches associated with the treatment of cancer. Current understanding of this disease brings to the fore a number of novel therapies that can be useful in the treatment of cancer. Among them, gene and cell therapies have emerged as novel and effective approaches. One of the most important challenges for cancer gene and cell therapies is correct monitoring of the modified genes and cells. In fact, visual tracking of therapeutic cells, immune cells, stem cells and genetic vectors that contain therapeutic genes and the various drugs is important in cancer therapy. Similarly, molecular imaging, such as nanosystems, fluorescence, bioluminescence, positron emission tomography, single photon-emission computed tomography and magnetic resonance imaging, have also been found to be powerful tools in monitoring cancer patients who have received therapeutic cell and gene therapies or drug therapies. In this review, we focus on these therapies and their molecular imaging techniques in treating and monitoring the progress of the therapies on various types of cancer.

  5. Exploration of the Emotional Avenues of Career Change.

    ERIC Educational Resources Information Center

    Chope, Robert C.

    The emotional fallout from rapid, dramatic job market changes can severely and adversely affect the job search and job change process. It can cause inappropriate, precipitous emotional reactions that can block a job seeker's effectiveness at different times and stages of each job search. This paper demonstrates how individuals can find their way…

  6. Parallel avenues in the evolution of hearts and pumping organs.

    PubMed

    Xavier-Neto, J; Castro, R A; Sampaio, A C; Azambuja, A P; Castillo, H A; Cravo, R M; Simões-Costa, M S

    2007-03-01

    Research in animal models established that tinman, a key gene in Drosophila dorsal vessel development, is an orthologue of Nkx2-5, a key gene in vertebrate cardiac development. Similarities between the arthropod dorsal vessel and vertebrate hearts are interpreted in light of concepts such as homology or convergence. We discuss this controversy in the context of the evolution of animal circulatory pumps and propose the distinction between peristaltic and chambered pumps as a fundamental parameter for evolutionary comparisons between bilaterian pumps. Neither homology nor convergence is satisfactory to explain the origins of hearts and pumping organs. Instead, we propose that animal pumps derive from parallel improvements of an ancestral, peristaltic design represented by a layer of myocytes at the external walls of primitive vessels. This paradigm unifies disparate views, impacts our understanding of bilaterian evolution and may be helpful to interpret similarities between pumping organs of phylogenetically relevant species and emerging models.

  7. Nonsteroidal anti-inflammatory drug gastropathy: new avenues for safety

    PubMed Central

    Roth, Sanford H

    2011-01-01

    Chronic oral or systemic nonselective nonsteroidal anti-inflammatory drug (NSAID) therapy, ubiquitously used by physicians to treat osteoarthritis-associated pain, is associated with a wide range of symptomatic adverse events, the most frequent and serious of which is gastropathy. Although cardiovascular and renal problems are a very real concern, they are significantly less frequent. These complications can be life-threatening in at-risk populations such as older adults, who are common users of long-term oral systemic NSAID therapy. Topical NSAID formulations deliver effective doses of analgesics directly to the affected joints, thereby limiting systemic exposure and potentially the risk of systemic adverse events, such as gastropathy and serious cardiovascular events. There are currently two topical NSAIDs approved by the US Food and Drug Administration for osteoarthritis-associated pain, as well as for the signs and symptoms of osteoarthritis. This review discusses the relative safety, and the gastrointestinal, cardiovascular, and renal risks of chronic oral or systemic NSAID therapy and topical NSAID formulations in patients with osteoarthritis. PMID:21753867

  8. Hemifacial hypertrophy: Exploring new avenues of treatment modalities

    PubMed Central

    Nandimath, Santosh Ashok; Rajkumar, G. C.; Nayak, Tulasi; Ashwin, D. P.; Rudresh, K. B.; Prashanth, R.

    2016-01-01

    Congenital hemihyperplasia is a rare developmental disorder characterized by unilateral overgrowth of one or more body parts resulting in marked asymmetry. We are reporting here, a case of true hemifacial hypertrophy in a young female adult highlighting the clinical features and possible treatment options. PMID:28163490

  9. Youth Sport Programs: An Avenue to Foster Positive Youth Development

    ERIC Educational Resources Information Center

    Fraser-Thomas, Jessica L.; Cote, Jean; Deakin, Janice

    2005-01-01

    Concern about the growth in adolescent problem behaviours (e.g. delinquency, drug use) has led to increased interest in positive youth development, and a surge in funding for "after school programs." We evaluate the potential of youth sport programs to foster positive development, while decreasing the risk of problem behaviours.…

  10. Mitophagy and disease: new avenues for pharmacological intervention.

    PubMed

    Taylor, Robert; Goldman, Scott J

    2011-01-01

    The process of intracellular macromolecular degradation known as macroautophagy has long been associated with the degradation of mitochondria. Recent studies have provided evidence that the process of mitochondria degradation via autophagy, now referred to as mitophagy, appears to be specifically targeted to mitochondria and highly regulated under both physiologic and pathologic conditions. This article provides a review of key developments in mitophagy research, including background information on the history, mechanisms, and regulation of macroautophagy, as well as discoveries that have enhanced our understanding of the specificity and independent regulation of mitophagy. This is followed by an analysis of how our current understanding of the mechanics and regulation of mitophagy may be exploited to yield pharmacological interventions for mitochondria-associated diseases. As yet, the potential for mitophagy-related pharmacological treatments for disease remains largely untapped. However, rapid progress in our understanding of both mitophagy and the pathology of mitochondria-related diseases is leading us towards the convergence of science and medicine which will inevitably result in new and potent pharmacological therapies for the treatment of these maladies.

  11. Nanodelivery: An Emerging Avenue for Nutraceuticals and Drug Delivery.

    PubMed

    Aklakur, Md; Asharf Rather, Mohd; Kumar, Neeraj

    2016-10-25

    Aquaculture has been globally recognized as the fastest growing food production sector which plays a major role in meeting the increasing demand for animal protein requirement. A consensus is growing that a dramatic increase in aquaculture is needed to supply future aquatic food needs. However, there are sustained problems with the aquaculture like disease outbreaks, chemical pollution, the environmental destruction, and inefficient feed utilization. These altogether raise question mark on sustainability of aquaculture. In spite of the several strategy adopted on national and international level, as improved laboratory facilities, diagnostic expertise, and control and therapeutic strategies in order to handle disease outbreaks more effectively. Aquaculture industry is under uncertainty and the progress has not matched that of the rapidly developing aquaculture sector. In order to control disease prevalence and ensure better health of system and sustainable production, the sector demand more technical innovation for the drug use, disease treatment, water quality management, production of tailored fish for suiting better health, productivity drive by epigenetic and nutrigenomic interaction, better breeding success by efficient delivery of maturation and spawning inducing agent, nutraceutical delivery for rapid growth promotion and culture time reduction, successful use of autotransgenic, and effective vaccine. Nanotechnology has a tremendous potential to revolutionize agriculture and allied fields including aquaculture and fisheries. For these multiple purposes effort, importance of nanotechnology and nanodelivery of drugs, vaccine, nutraceutical, inducing hormones, and growth-promoting anabolics open tremendous opportunity. The paper has been targeted to delineate the possible future application of nanodelivery for the aquaculture development.

  12. Dietary delivery: A new avenue for microRNA therapeutics?

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Many people carefully monitor their food choices, adhering to the philosophy that you are what you eat. Recent research adds to a new wrinkle to that old adage, suggesting that dietary small RNAs (sRNAs) can control the gene expression of the consumer and may provide an effective, noninvasive, and i...

  13. Molecular marker systems in insects: current trends and future avenues.

    PubMed

    Behura, Susanta K

    2006-10-01

    Insects comprise the largest species composition in the entire animal kingdom and possess a vast undiscovered genetic diversity and gene pool that can be better explored using molecular marker techniques. Current trends of application of DNA marker techniques in diverse domains of insect ecological studies show that mitochondrial DNA (mtDNA), microsatellites, random amplified polymorphic DNA (RAPD), expressed sequence tags (EST) and amplified fragment length polymorphism (AFLP) markers have contributed significantly for progresses towards understanding genetic basis of insect diversity and for mapping medically and agriculturally important genes and quantitative trait loci in insect pests. Apart from these popular marker systems, other novel approaches including transposon display, sequence-specific amplification polymorphism (S-SAP), repeat-associated polymerase chain reaction (PCR) markers have been identified as alternate marker systems in insect studies. Besides, whole genome microarray and single nucleotide polymorphism (SNP) assays are becoming more popular to screen genome-wide polymorphisms in fast and cost effective manner. However, use of such methodologies has not gained widespread popularity in entomological studies. The current study highlights the recent trends of applications of molecular markers in insect studies and explores the technological advancements in molecular marker tools and modern high throughput genotyping methodologies that may be applied in entomological researches for better understanding of insect ecology at molecular level.

  14. Diabetic Macular Edema: From Old Concepts to New Therapeutic Avenues.

    PubMed

    Mansour, Ahmad M; Pulido, Jose S; Arevalo, J Fernando

    2015-01-01

    Diabetic macular edema (DME) is a significant cause of blindness in the working population and is currently challenging to treat. Current interventions include focal laser or intravitreal injections. This article outlines a new treatment protocol based on the theory that peripheral ischemia is the precursor to angiogenesis, which will ultimately gather its momentum at the fovea. Extreme peripheral light laser panretinal photocoagulation (PRP) back to the equator reduces excessive production of the vascular endothelial growth factor (VEGF) in the eye. This decreases VEGF-induced DME and provides long-term protection against the development of neovascularization. Initial exacerbation of DME often accompanies PRP. Therefore, injections of anti-VEGF agents (with or without dexamethasone implants) initially can forestall worsening of DME and prevent loss of vision. However, on the other hand, applying peripheral PRP and intraocular injections can induce posterior vitreous detachment (PVD). This could help release vitreomacular adhesions (VMA) and vitreomacular traction (VMT), thereby decreasing DME severity and improving the response to intravitreal injections. In the current approach, peripheral retinal photocoagulation should stop the drive for VEGF release; moreover, laser ablation should produce secondary, accidental, and beneficial PVD. This approach precludes focal laser therapy and paves the path for prolonged intervals between anti-VEGF therapy.

  15. Religious and Spiritual Beliefs: An Avenue to Explore End-of-Life Issues

    ERIC Educational Resources Information Center

    Reiner, Summer M.

    2007-01-01

    This literature review highlights the relationship between spirituality and/or religion and how people respond in the face of impending death. Attitudes toward physician-assisted suicide and hospice are explored. The author also offers recommendations to counselors for addressing religious and spiritual concerns.

  16. Hazelwood Interim Storage Site environmental report for calendar year 1992, 9200 Latty Avenue, Hazelwood, Missouri

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Hazelwood Interim storage Site (HISS) and surrounding area, provides the results for 1992, and discusses applicable environmental standards and requirements with which the results were compared. HISS is located in eastern Missouri in the City of Hazelwood (St. Louis County) and occupies approximately 2.2 ha (5.5 acres). Environmental monitoring of HISS began in 1984 when the site was assigned to the US Department of Energy (DOE) as part of the decontamination research and development project authorized by Congress under the 1984 Energy and Water Development Appropriations Act. DOE placed responsibility for HISS under the Formerly Utilized Sites Remedial Action Program (FUSRAP), which was established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. In 1992 there were no environmental occurrences or unplanned contaminant releases as defined in DOE requirements and in the Superfund Amendment and Reauthorization Act (SARA) Title III of CERCLA.

  17. Learning from Our Learning Spaces: A Portrait of 695 Park Avenue

    ERIC Educational Resources Information Center

    Kushins, Jodi; Brisman, Avi

    2005-01-01

    The perspective that the physical structure--the classroom, the building, the campus--in which one learns is irrelevant or, at best, ancillary to what transpires within the walls of the institution is troubling, especially for those concerned with educating individuals in the ways in which design and behavior interact. In this article, the authors…

  18. Methylglyoxal and glucose metabolism: a historical perspective and future avenues for research.

    PubMed

    Kalapos, Miklós Péter

    2008-01-01

    Methylglyoxal, an alpha-oxoaldehyde discovered in the 1880s, has had a hectic scientific career, at times being considered of fundamental importance and at other times viewed as playing a very subordinate role. Much has been learned about methylglyoxal, but the function of its production in the metabolic machinery is still unknown. This paper gives an overview of the changing role of methylglyoxal from a historical aspect and arrives at the conclusion that methylglyoxal is tightly bound to glycolysis from an evolutionary perspective, its production therefore being inevitable. It is not situated in the main stream of the glycolytic sequence, but a role can be assigned to its production in the phosphate supply of operating glycolysis in some prokaryotes and yeast under conditions of phosphate deficiency. This function is presumed to be performed by the enzyme methylglyoxal synthase, which is specialized for the conversion of dihydroxyacetone-phosphate to methylglyoxal. However, it is still unknown whether this enzyme and this kind of regulation also exist in animals.

  19. Implementing and Simulating Dynamic Traffic Assignment with Intelligent Transportation Systems in Cube Avenue

    NASA Technical Reports Server (NTRS)

    Foytik, Peter; Robinson, Mike

    2010-01-01

    As urban populations and traffic congestion levels increase, effective use of information and communication tools and intelligent transportation systems as becoming increasingly important in order to maximize the efficiency of transportation networks. The appropriate placement and employment of these tools within a network is critical to their effectiveness. This presentation proposes and demonstrates the use of a commercial transportation simulation tool to simulate dynamic traffic assignment and rerouting to model route modifications as a result of traffic information.

  20. Probabilistic inversion in the context of EM studies: Where we are and avenues for the future

    NASA Astrophysics Data System (ADS)

    Linde, Niklas; Rosas-Carbajal, Marina

    2016-04-01

    Modern Markov chain Monte Carlo (MCMC) algorithms can explore the posterior distribution of highly non-linear inverse problems in moderately high dimensions. For instance, 2-D magnetotelluric inversion is feasible for several hundreds of independent model parameters. At present, 3-D applications are limited to a few tenths of model parameters, but even such low dimensions make MCMC useful in time-lapse inversions when using appropriate model parameterizations. It is straightforward to invert for the noise level of the data (i.e., hierarchical Bayes) and the appropriate strength of the prior constraints (i.e., empirical Bayes). It is even possible to consider the dimension of the problem as an unknown (i.e., reversible-jump or transdimensional inversion). Nevertheless, persistent problems that plague MCMC inversions in geophysics include the choice of the prior probability density function, overly simplistic descriptions of data and modeling errors in the likelihood function, as well as truncation errors or spectral leakage that are inevitable when describing the Earth by a finite number of parameters. This leads to uncertainty estimates that often are overly optimistic (or alternatively limited by a too restrictive set of hypotheses) and final results that at times are only vaguely more informative than those obtained by classical Occam inversions. We argue that formal model selection, multiple-point statistics and approximate Bayesian computation may offer solutions to overcome some of these outstanding issues.

  1. New avenues to efficient chemical synthesis of exchange coupled hard/soft nanocomposite magnet.

    PubMed

    Lee, Don Keun; Cha, Hyun Gil; Kim, Young Hwan; Kim, Chang Woo; Ji, Eun Sun; Kang, Young Soo

    2009-07-01

    Nd-Fe-B ultrafine amorphous alloy particles were prepared by reaction of metal ions with borohydride in aqueous solution. Monodispersed Fe nanoparticles were synthesized under an argon atmosphere via thermal decomposition of Fe(2+)-oleate2. Exchange coupled Nd2Fe14B/Fe nanocomposite magnets have been prepared by self-assembly using surfactant. The crystal structure of the synthesized nanoparticles was identified by using X-ray powder diffraction (XRD). The size and shape of nanoparticles were obtained by transmission electron microscope (TEM). Thermogravimetry using a microbalance with magnetic field gradient positioned below the sample was used for the measurement of a thermomagnetic analysis (TMA) curve showing the downward magnetic force versus temperature.

  2. Pseudospectral sampling of Gaussian basis sets as a new avenue to high-dimensional quantum dynamics

    NASA Astrophysics Data System (ADS)

    Heaps, Charles

    This thesis presents a novel approach to modeling quantum molecular dynamics (QMD). Theoretical approaches to QMD are essential to understanding and predicting chemical reactivity and spectroscopy. We implement a method based on a trajectory-guided basis set. In this case, the nuclei are propagated in time using classical mechanics. Each nuclear configuration corresponds to a basis function in the quantum mechanical expansion. Using the time-dependent configurations as a basis set, we are able to evolve in time using relatively little information at each time step. We use a basis set of moving frozen (time-independent width) Gaussian functions that are well-known to provide a simple and efficient basis set for nuclear dynamics. We introduce a new perspective to trajectory-guided Gaussian basis sets based on existing numerical methods. The distinction is based on the Galerkin and collocation methods. In the former, the basis set is tested using basis functions, projecting the solution onto the functional space of the problem and requiring integration over all space. In the collocation method, the Dirac delta function tests the basis set, projecting the solution onto discrete points in space. This effectively reduces the integral evaluation to function evaluation, a fundamental characteristic of pseudospectral methods. We adopt this idea for independent trajectory-guided Gaussian basis functions. We investigate a series of anharmonic vibrational models describing dynamics in up to six dimensions. The pseudospectral sampling is found to be as accurate as full integral evaluation, while the former method is fully general and integration is only possible on very particular model potential energy surfaces. Nonadiabatic dynamics are also investigated in models of photodissociation and collinear triatomic vibronic coupling. Using Ehrenfest trajectories to guide the basis set on multiple surfaces, we observe convergence to exact results using hundreds of basis functions. The pseudospectral sampling of Gaussian basis functions introduces a new and efficient means of calculating the underlying quantum mechanics associated with trajectory-guided basis sets. We also discuss the conceptual connections to the quantum trajectory method and the benefits of solving quantum mechanics on a discrete grid. We include a chapter studying the strengths and weaknesses of the parametric two-electron reduced-density-matrix (p2-RDM) method for systems susceptible to delocalization error. Density matrix methods are known to overestimate the energetic effects of electron delocalization, including severe effects such as diatomic dissociation to fractionally charged atoms. We consider the role of delocalization error in p2-RDM and demonstrate that the p2-RDM is resistant to delocalization error in challenging cases.

  3. Technical and Vocational Education in Cameroon and Critical Avenues for Development

    ERIC Educational Resources Information Center

    Che, S. Megan

    2007-01-01

    Technical and vocational education (TVE) can influence development and economic progress for post-colonial societies. Some newly independent sub-Saharan African countries attempted curricular transformation that might produce a skilled workforce through widespread access to versions of TVE. In Cameroon, no such post-colonial curricular revolution…

  4. New avenues to an old material: controlled nanoscale doping of germanium.

    PubMed

    Scappucci, Giordano; Capellini, Giovanni; Klesse, Wolfgang M; Simmons, Michelle Y

    2013-04-07

    We review our recent research into n-type doping of Ge for nanoelectronics and integrated photonics. We demonstrate a doping method in ultra-high vacuum to achieve high electron concentrations in Ge while maintaining atomic-level control of the doping process. We integrated this doping technique with ultra-high vacuum scanning tunneling microscope lithography and femtosecond laser ablation micron-scale lithography, and demonstrated basic components of donor-based nanoelectronic circuitry such as wires and tunnel gaps. By repetition of controlled doping cycles we have shown that stacking of multiple Ge:P two-dimensional electron gases results in high electron densities in Ge (>10(20) cm(-3)). Because of the strong vertical electron confinement, closely stacked 2D layers - although interacting - maintain their individuality in terms of electron transport. These results bode well towards the realization of nanoscale 3D epitaxial circuits in Ge comprising stacked 2DEGs and/or atomic-scale Ge:P devices with confinement in more dimensions.

  5. Exploring Symmetry as an Avenue to the Computational Design of Large Protein Domains

    SciTech Connect

    Fortenberry, Carie; Bowman, Elizabeth Anne; Proffitt, Will; Dorr, Brent; Combs, Steven; Harp, Joel; Mizoue, Laura; Meiler, Jens

    2012-03-15

    It has been demonstrated previously that symmetric, homodimeric proteins are energetically favored, which explains their abundance in nature. It has been proposed that such symmetric homodimers underwent gene duplication and fusion to evolve into protein topologies that have a symmetric arrangement of secondary structure elements - 'symmetric superfolds'. Here, the ROSETTA protein design software was used to computationally engineer a perfectly symmetric variant of imidazole glycerol phosphate synthase and its corresponding symmetric homodimer. The new protein, termed FLR, adopts the symmetric ({beta}{alpha}){sub 8} TIM-barrel superfold. The protein is soluble and monomeric and exhibits two-fold symmetry not only in the arrangement of secondary structure elements but also in sequence and at atomic detail, as verified by crystallography. When cut in half, FLR dimerizes readily to form the symmetric homodimer. The successful computational design of FLR demonstrates progress in our understanding of the underlying principles of protein stability and presents an attractive strategy for the in silico construction of larger protein domains from smaller pieces.

  6. Avenues of international cooperation in power plants life assessment and management

    SciTech Connect

    Isreb, M.

    1999-11-01

    The present paper examines various attributes, sources of funding and areas of international cooperation in power plants life assessment and management. The attributes discussed in the paper are themes, strategies, benefits and mechanism. Next, the paper focuses on the Australian-American cooperation and sources of funding. In this regard, the paper concentrates on major funding organizations from Australia and the United States such as the Australian Department of Employment, Education, Training and Youth Affairs (DEETYA), the Australian Department of Industry, Science and Tourism (DIST) and the American National Science Foundation (NSF). Finally, the paper presents the area of cooperation in line with the major thrust of the Australian power industry. The paper examines possible subject areas of international cooperation, in relation to efficiency, diversification of fuels and thermal and environmental aspects.

  7. IMPORTANT BUT INCOMPLETE: PLAN B AS AN AVENUE FOR POST-ASSAULT CARE

    PubMed Central

    Munro, Michelle L.; Martyn, Kristy K.; Campbell, Rebecca; Graham-Bermann, Sandra; Seng, Julia S.

    2016-01-01

    Many survivors of rape do not seek post-assault care. The recent change in status of emergency contraception (EC), such as Plan B, to an over-the-counter (OTC) product may be further changing post-assault care-seeking. This descriptive study will quantify OTC EC use in the post-assault period and elicit survivors’ desires for care. Data were collected from women purchasing OTC EC at university pharmacies (n=55) and students in an undergraduate university class (n=165). Quantitative results indicate annual prevalence rates of post-assault OTC EC use as 5.4%-7.3%. Qualitative analyses indicate OTC EC is an important but incomplete form of post-assault care. Future work should focus on intervention development to provide all OTC EC users with information about post-assault resources to prevent long-term sequelae. PMID:27293493

  8. Non-Verbal Communication Training: An Avenue for University Professionalizing Programs?

    ERIC Educational Resources Information Center

    Gazaille, Mariane

    2011-01-01

    In accordance with today's workplace expectations, many university programs identify the ability to communicate as a crucial asset for future professionals. Yet, if the teaching of verbal communication is clearly identifiable in most university programs, the same cannot be said of non-verbal communication (NVC). Knowing the importance of the…

  9. [Media coverage of suicide: From the epidemiological observations to prevention avenues].

    PubMed

    Notredame, Charles-Édouard; Pauwels, Nathalie; Walter, Michel; Danel, Thierry; Vaiva, Guillaume

    2015-12-01

    Media coverage of suicide can result in increased morbi-mortality suicidal rates, due to an imitation process in those who are particularly vulnerable. This phenomenon is known as "Werther effect". Werther effect's magnitude depends on several qualitative and quantitative characteristics of the media coverage, in a dose-effect relationship. An extensive (in terms of audience and history repetition) and salient coverage (glorification of suicide, description of the suicidal method, etc.) increases the risk of contagion. Celebrities' suicide is particularly at risk of Werther effect. Media may also have a preventive role with respect to suicide. Indeed, according to "Papageno effect", journalists could, under certain conditions, help preventing suicide when reporting suicide stories. Two main theories in the field of social psychology have been proposed to account for Werther and Papageno effects: social learning theory and differential identification. Identification of Werther and Papageno effects uncovers new responsibilities and potentialities for the journalists in terms of public health. Their description provides a basis for promising targeted prevention actions.

  10. Mutualism between tree shrews and pitcher plants: perspectives and avenues for future research.

    PubMed

    Clarke, Charles; Moran, Jonathan A; Chin, Lijin

    2010-10-01

    Three species of Nepenthes pitcher plants from Borneo engage in a mutualistic interaction with mountain tree shrews, the basis of which is the exchange of nutritional resources. The plants produce modified "toilet pitchers" that produce copious amounts of exudates, the latter serving as a food source for tree shrews. The exudates are only accessible to the tree shrews when they position their hindquarters over the pitcher orifice. Tree shrews mark valuable resources with faeces and regularly defecate into the pitchers when they visit them to feed. Faeces represent a valuable source of nitrogen for these Nepenthes species, but there are many facets of the mutualism that are yet to be investigated. These include, but are not limited to, seasonal variation in exudate production rates by the plants, behavioral ecology of visiting tree shrews, and the mechanism by which the plants signal to tree shrews that their pitchers represent a food source. Further research into this extraordinary animal-plant interaction is required to gain a better understanding of the benefits to the participating species.

  11. G protein-coupled receptors as oncogenic signals in glioma: emerging therapeutic avenues

    PubMed Central

    Cherry, Allison E; Stella, Nephi

    2014-01-01

    Gliomas are the most common malignant intracranial tumors. Newly developed targeted therapies for these cancers aim to inhibit oncogenic signals, many of which emanate from receptor tyrosine kinases, including the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptor (VEGFR). Unfortunately, the first generation treatments targeting these oncogenic signals provide little survival benefit in both mouse xenograft models and human patients. The search for new treatment options has uncovered several G protein-coupled receptor (GPCR) candidates and generated a growing interest in this class of proteins as alternative therapeutic targets for the treatment of various cancers, including GBM. GPCRs constitute a large family of membrane receptors that influence oncogenic pathways through canonical and non-canonical signaling. Accordingly, evidence indicates that GPCRs display a unique ability to crosstalk with receptor tyrosine kinases, making them important molecular components controlling tumorigenesis. This review summarizes the current research on GPCR functionality in gliomas and explores the potential of modulating these receptors to treat this devastating disease. PMID:25158675

  12. A Microbial Avenue to Cell Cycle Control in the Plant Superkingdom[C][W][OPEN

    PubMed Central

    Tulin, Frej; Cross, Frederick R.

    2014-01-01

    Research in yeast and animals has resulted in a well-supported consensus model for eukaryotic cell cycle control. The fit of this model to early diverging eukaryotes, such as the plant kingdom, remains unclear. Using the green alga Chlamydomonas reinhardtii, we developed an efficient pipeline, incorporating robotics, semiautomated image analysis, and deep sequencing, to molecularly identify >50 genes, mostly conserved in higher plants, specifically required for cell division but not cell growth. Mutated genes include the cyclin-dependent kinases CDKA (resembling yeast and animal Cdk1) and the plant-specific CDKB. The Chlamydomonas cell cycle consists of a long G1 during which cells can grow >10-fold, followed by multiple rapid cycles of DNA replication and segregation. CDKA and CDKB execute nonoverlapping functions: CDKA promotes transition between G1 and entry into the division cycle, while CDKB is essential specifically for spindle formation and nuclear division, but not for DNA replication, once CDKA-dependent initiation has occurred. The anaphase-promoting complex is required for similar steps in the Chlamydomonas cell cycle as in Opisthokonts; however, the spindle assembly checkpoint, which targets the APC in Opisthokonts, appears severely attenuated in Chlamydomonas, based on analysis of mutants affecting microtubule function. This approach allows unbiased integration of the consensus cell cycle control model with innovations specific to the plant lineage. PMID:25336509

  13. Model of Anoxic-Aerobic Wastewater Treatment at Phoenix 91st Avenue Plant

    DTIC Science & Technology

    1993-01-01

    at higher DO concentrations, where oxygen is used as the electron acceptor. 18 Oxyten Consumption Equations for the dissolved oxygen consumption rate...is shown below as an example: Stage 6 (Ox-2) Dissolved Oxygen Consumption Rate (Kg 02 / hr) per stage = r.+1. 42(Kd )( K+ 06 X )JX)(V, ) +(3. 22...represents the depletion of N0 3-N by heterotrophic utilization of stored soluble substrate. Modification #3 For dissolved oxygen consumption , the

  14. Exploring exercise as an avenue for the treatment of anxiety disorders

    PubMed Central

    DeBoer, Lindsey B; Powers, Mark B; Utschig, Angela C; Otto, Michael W; Smits, Jasper AJ

    2012-01-01

    Anxiety disorders constitute a significant public health problem. Current gold standard treatments are limited in their effectiveness, prompting the consideration of alternative approaches. In this review, we examine the evidence for exercise as an intervention for anxiety disorders. This evidence comes from population studies, studies of nonclinical anxiety reduction, as well as a limited number of studies of clinically anxious individuals. All of these studies provide converging evidence for consistent beneficial effects of exercise on anxiety, and are consistent with a variety of accounts of the mechanism of anxiety reduction with exercise. Further study of clinical populations is encouraged, as are studies of the mechanism of change of exercise interventions, which have the potential to help refine exercise intervention strategies. Likewise, studies that identify moderators of treatment efficacy will assist clinicians in deciding how and for whom to prescribe exercise. PMID:23002943

  15. Can the american high school become an avenue of advancement for all?

    PubMed

    Balfanz, Robert

    2009-01-01

    As the twenty-first century opens, says Robert Balfanz, the United States is developing a deep social consensus that American high schools should ensure that all adolescents graduate from high school prepared for postsecondary schooling and training. Balfanz asks how well high schools are succeeding in this mission and whether they can ultimately fulfill it. Balfanz first surveys the structure and demographics of today's high schools. Forty percent of white students attend high schools that are 90 percent or more white, while roughly one-third of Latino and African American students attend high schools that are 90 percent or more minority. Minority students are also much more likely than white students to attend high schools that confront the challenges of concentrated poverty. In predominantly white, affluent suburban school districts, nearly every student arrives ready for high school work and then graduates. In all-minority inner city schools in high-poverty neighborhoods, most entering students lack a good middle school education and only half to two-thirds graduate. With only a third to a half of high school graduates today prepared to succeed in college, how likely is it that American high schools will succeed in their mission of preparing all students for additional schooling or training? Balfanz argues that reforms over the past twenty-five years offer some hope. The standards and accountability movement has made the American high school a more focused and academic place. College preparatory course-taking has increased substantially, as has standardized testing. Mandatory exit exams have been imposed. And during the past decade, in particular, reformers have made a concerted effort to improve the low-performing high schools that serve low-income and minority students. Investments by the federal government and by foundations have led to the development of several types of reforms that have been proven effective, thus raising hopes that the nation's lowest-performing high schools can better serve their students. Still, the American high school has a considerable way to go to be able to prepare all students for further schooling or training. To advance all its students, it must find a way to bring to scale the methods and mechanisms, conditions, and know-how that have enabled a few low-performing high schools to achieve this transformation.

  16. A New Avenue for Classification and Prediction of Olive Cultivars Using Supervised and Unsupervised Algorithms

    PubMed Central

    Beiki, Amir H.; Saboor, Saba; Ebrahimi, Mansour

    2012-01-01

    Various methods have been used to identify cultivares of olive trees; herein we used different bioinformatics algorithms to propose new tools to classify 10 cultivares of olive based on RAPD and ISSR genetic markers datasets generated from PCR reactions. Five RAPD markers (OPA0a21, OPD16a, OP01a1, OPD16a1 and OPA0a8) and five ISSR markers (UBC841a4, UBC868a7, UBC841a14, U12BC807a and UBC810a13) selected as the most important markers by all attribute weighting models. K-Medoids unsupervised clustering run on SVM dataset was fully able to cluster each olive cultivar to the right classes. All trees (176) induced by decision tree models generated meaningful trees and UBC841a4 attribute clearly distinguished between foreign and domestic olive cultivars with 100% accuracy. Predictive machine learning algorithms (SVM and Naïve Bayes) were also able to predict the right class of olive cultivares with 100% accuracy. For the first time, our results showed data mining techniques can be effectively used to distinguish between plant cultivares and proposed machine learning based systems in this study can predict new olive cultivars with the best possible accuracy. PMID:22957050

  17. Grassland-Cropping Rotations: An Avenue for Agricultural Diversification to Reconcile High Production with Environmental Quality.

    PubMed

    Lemaire, Gilles; Gastal, François; Franzluebbers, Alan; Chabbi, Abad

    2015-11-01

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity at all levels of organization, i.e., field, farm, landscape, and region. Therefore, we postulate that negative environmental impacts of modern agriculture are due more to production simplification than to inherent characteristics of agricultural productivity. Thus by enhancing diversity within agricultural systems, it should be possible to reconcile high quantity and quality of food production with environmental quality. Intensification of livestock and cropping systems separately within different specialized regions inevitably leads to unacceptable environmental impacts because of the overly uniform land use system in intensive cereal areas and excessive N-P loads in intensive animal areas. The capacity of grassland ecosystems to couple C and N cycles through microbial-soil-plant interactions as a way for mitigating the environmental impacts of intensive arable cropping system was analyzed in different management options: grazing, cutting, and ley duration, in order to minimize trade-offs between production and the environment. We suggest that integrated crop-livestock systems are an appropriate strategy to enhance diversity. Sod-based rotations can temporally and spatially capture the benefits of leys for minimizing environmental impacts, while still maintaining periods and areas of intensive cropping. Long-term experimental results illustrate the potential of such systems to sequester C in soil and to reduce and control N emissions to the atmosphere and hydrosphere.

  18. Luminescence dating of interglacial coastal depositional systems: Recent developments and future avenues of research

    NASA Astrophysics Data System (ADS)

    Lamothe, Michel

    2016-08-01

    Luminescence dating offers new opportunities to explore the evolution of Quaternary marine coastal facies and landforms. This review highlights the main advances in luminescence geochronology of interglacial coastal sediments through the analysis of 547 luminescence ages, most of which were published during the last decade. The majority of these reported luminescence investigations have been carried out along passive margin coasts. Since the turn of the century, the discovery of a normalization procedure known as Single Aliquot Regeneration (SAR) has drastically reduced data scatter and improved precision, with the consequence that quartz SAR optically-stimulated luminescence OSL has become the dating protocol of choice for the Last Interglacial (LIG) period. A more complex technique, known as thermally-transferred OSL (TT-OSL), is presumably proposed for dating older interglacials of the Mid-Pleistocene and beyond. Feldspar luminescence is increasingly being applied to dating Pleistocene sea level high stands due to a much higher dose saturation level than quartz OSL. The use of feldspar IRSL (Infrared-stimulated luminescence) is limited by the occurrence of variable, but ubiquitous anomalous fading (AF). Following the advent of AF-correction methods, several Middle Pleistocene sites have been amenable to dating, albeit with significant related uncertainties. Recently, new protocols involving the measurement of post-IR IRSL at elevated temperatures have yielded relatively coherent ages for interglacial sediments up to ca. 300 ka. Quartz OSL/TT-OSL, AF-corrected IRSL, and post-IR IRSL ages are generally correlated with periods of sea level high stands. A few ages are reported from the early and middle part of the Middle Pleistocene, as MIS11, 9 and more commonly MIS7 high stands are documented in strongly uplifting active margin coasts. However, by far the most obvious age peak corresponds to the end of the LIG. The MIS5e shoreline is probably the most studied and luminescence-dated coastal feature of all, as the chronology of the sea level markers is crucial to assess global eustatic sea level variations through the course of the last interglacial. Nevertheless, the observed abundance of young (100-120 ka) luminescence ages for presumed MIS5e sediments may underline methodological issues, and/or reflect the higher preservation potential of late regressive sequences. On the other hand, the occurrence of geographically distant reports of MIS5a high stand might reflect a true eustatic origin for this event. Age analysis supports the impression of general reliability of luminescence for the timing of former sea level high stands. There is a clear need to address issues in dose rate variability, in the phenomenology of fading in feldspar, and in the behaviour of luminescence growth with dose, both in laboratory and natural conditions. These could be addressed and properly evaluated by dating different minerals, as multiple or single grains, with consequent variable internal dose rates. More robust practices in the application of luminescence dating techniques could eventually constrain the age uncertainties to no better than 2-3%. Therefore, the strength of luminescence as a dating tool is more in terms of its extended age range and the ubiquity of datable material.

  19. Avenues for Scientist Involvement in Earth and Space Science Education and Public Outreach (Invited)

    NASA Astrophysics Data System (ADS)

    Peticolas, L. M.; Gross, N. A.; Hsu, B. C.; Shipp, S. S.; Buxner, S.; Schwerin, T. G.; Smith, D.; Meinke, B. K.

    2013-12-01

    NASA's Science Mission Directorate (SMD) Science Education and Public Outreach (E/PO) Forums are charged with engaging, extending, supporting, and coordinating the community of E/PO professionals and scientists involved in Earth and space science education activities. This work is undertaken to maximize the effectiveness and efficiency of the overall national NASA science education and outreach effort made up of individual efforts run by these education professionals. This includes facilitating scientist engagement in education and outreach. A number of resources and opportunities for involvement are available for scientists involved in - or interested in being involved in - education or outreach. The Forums provide opportunities for earth and space scientists to stay informed, communicate, collaborate, leverage existing programs and partnerships, and become more skilled education practitioners. Interested scientists can receive newsletters, participate in monthly calls, interact through an online community workspace, and attend E/PO strategic meetings. The Forums also provide professional development opportunities on a myriad of topics, from common pre-conceptions in science, to program evaluation, to delivering effective workshops. Thematic approaches, such as Earth Science Week (http://www.earthsciweek.org), and the Year of the Solar System (http://solarsystem.nasa.gov/yss) are coordinated by the Forums; through these efforts resources are presented topically, in a manner that can be easily ported into diverse learning environments. Information about the needs of audiences with which scientists interact - higher education, K-12 education, informal education, and public - are provided by SMD's Audience-Based Working Groups. Their findings and recommendations are made available to inform the activities and products of E/PO providers so they are able to better serve these audiences. Also available is a 'one-stop shop' of SMD E/PO products and resources that can be used in conjunction with E/PO activities, NASA Wavelength (http://nasawavelength.org). Further supporting higher-education efforts, the Forums coordinate a network of science faculty, bringing them together at science conferences to share resources and experiences and to discuss pertinent education research. An online higher education clearinghouse, EarthSpace (http://www.lpi.usra.edu/earthspace), has been developed to provide faculty with news and funding information, the latest education research and resources for teaching undergraduates, and undergraduate course materials, including lectures, labs, and homework. This presentation will explore the Science E/PO Forums' pathways and tools available to support scientists involved in - or interested in being involved in - E/PO.

  20. Avenues for Scientist Involvement in Planetary Science Education and Public Outreach

    NASA Astrophysics Data System (ADS)

    Shipp, S. S.; Buxner, S.; Cobabe-Ammann, E. A.; Dalton, H.; Bleacher, L.; Scalice, D.

    2012-12-01

    The Planetary Science Education and Public Outreach (E/PO) Forum is charged by NASA's Science Mission Directorate (SMD) with engaging, extending, and supporting the community of E/PO professionals and scientists involved in planetary science education activities in order to help them more effectively and efficiently share NASA science with all learners. A number of resources and opportunities for involvement are available for planetary scientists involved in - or interested in being involved in - E/PO. The Forum provides opportunities for community members to stay informed, communicate, collaborate, leverage existing programs and partnerships, and become more skilled education practitioners. Interested planetary scientists can receive newsletters, participate in monthly calls, interact through an online community workspace, and attend annual E/PO community meetings and meetings of opportunity at science and education conferences. The Forum also provides professional development opportunities on a myriad of topics, from common pre-conceptions in planetary science to program evaluation, to delivering effective workshops. Thematic approaches, such as the Year of the Solar System (http://solarsystem.nasa.gov/yss), are coordinated by the Forum; through these efforts resources are presented topically, in a manner that can be easily ported into diverse learning environments. Information about the needs of audiences with which scientists interact - higher education, K-12 education, informal education, and public - currently is being researched by SMD's Audience-Based Working Groups. Their findings and recommendations will be made available to inform the activities and products of E/PO providers so they are able to better serve these audiences. Also in production is a "one-stop-shop" of SMD E/PO products and resources that can be used in conjunction with E/PO activities. Further supporting higher-education efforts, the Forum coordinates a network of planetary science faculty, bringing them together at science conferences to share resources and experiences and to discuss pertinent education research. An online higher education clearinghouse, (EarthSpace - http://www.lpi.usra.edu/earthspace), has been developed to provide faculty with news and funding information, the latest education research and resources for teaching undergraduates, and undergraduate course materials, including lectures, labs, and homework. The presentation will explore the Planetary Science E/PO Forum pathways and tools available to support scientists involved in - or interested in being involved in - E/PO.

  1. Technology: Student Animation Projects: An Avenue to Promote Creativity and Learning

    ERIC Educational Resources Information Center

    Siegle, Del

    2014-01-01

    Using readily available technology, students of all ages can easily create impressive animated products. Animation allows educators to capitalize on the natural desire that students of all ages hold to tell stories and share their understanding of the world. In the course of planning their animations, students conduct research on topics, organize…

  2. New avenues for the pharmacological management of type 2 diabetes: an update.

    PubMed

    Cuny, Thomas; Guerci, Bruno; Cariou, Bertrand

    2012-11-01

    Type 2 diabetes mellitus (T2DM) is one of the most troubling chronic disease regarding the huge number of new cases diagnosed annually worldwide. Currently available oral antidiabetic drugs (OADs) attempt to correct the underlying pathophysiological dysfunctions leading to T2DM: insulin resistance for the insulin sensitizers (metformin and thiazolidinediones), and impaired insulin secretion for the insulin secretagogues (sulfonylureas, glinides and more recently incretin mimetics). Incretin-based therapies include GLP-1 receptor agonists that provide pharmacologic levels of GLP-1 receptor stimulation beyond those that would occur from the action of the native hormone alone, and dipeptidyl-peptidase-4 (DPP-4) inhibitors that preserve endogenous GLP-1 by decreasing its degradation by the DPP-4 enzyme. In 2012, the development of new OADs aims to target untapped pathophysiological aspects of the disease (kidney homeostasis, glucagon signalling, chronic low-grade inflammation) for tailoring glycaemic control in T2DM. SGLT-2 inhibitors are the most advanced new OADs that lower HbA1C by increasing glycosuria and lead to a moderate weight loss. Although there is genuine hope that the range of OADs can be extended, a long-term evaluation of side effects and true clinical benefits is necessary.

  3. Recent Developments in Neurofibromatoses and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues

    PubMed Central

    Rauen, Katherine A.; Huson, Susan M.; Burkitt-Wright, Emma; Evans, D Gareth; Farschtschi, Said; Ferner, Rosalie E; Gutmann, David H.; Hanemann, C Oliver; Kerr, Bronwyn; Legius, Eric; Parada, Luis F; Patton, Michael; Peltonen, Juha; Ratner, Nancy; Riccardi, Vincent M.; van der Vaart, Thijs; Vikkula, Miikka; Viskochil, David H.; Zenker, Martin; Upadhyaya, Meena

    2014-01-01

    Neurofibromatosis type 1 was the first RASopathy and is now one of many RASopathies that are caused by germline mutations in genes that encode components of the Ras/mitogen-activated protein kinase (MAPK) pathway. Their common underlying pathogenetic etiology causes significant overlap in phenotypic features which includes craniofacial dysmorphology, cardiac, cutaneous, musculoskeletal, GI and ocular abnormalities, and a predisposition to cancer. The proceedings from the symposium “Recent Developments in Neurofibromatoses and RASopathies: Management, Diagnosis and Current and Future Therapeutic Avenues” chronicle this timely and topical clinical translational research symposium. The overarching goal was to bring together clinicians, basic scientists, physician-scientists, advocate leaders, trainees, students and individuals with Ras pathway syndromes to discuss the most state-of-the-art basic science and clinical issues in an effort to spark collaborations directed towards the best practices and therapies for individuals with RASopathies. PMID:25393061

  4. Art as an Avenue to Science Literacy: Teaching Nanotechnology through Stained Glass

    ERIC Educational Resources Information Center

    Duncan, Kimberly A.; Johnson, Chris; McElhinny, Kyle; Ng, Steve; Cadwell, Katie D.; Zenner Petersen, Greta M.; Johnson, Angela; Horoszewski, Dana; Gentry, Ken; Lisensky, George; Crone, Wendy C.

    2010-01-01

    Nanoscale science and engineering (NSE) and nanotechnology are emerging fields that have captured the attention of scientists and engineers, as well as mainstream media. However, the general public is relatively unaware of NSE, and schools (both K-12 and undergraduate institutions) rarely include nanotechnology as part of their curriculum. To help…

  5. American Indian Internet Cigarette Sales: Another Avenue for Selling Tobacco Products

    PubMed Central

    Hodge, Felicia S.; Geishirt Cantrell, Betty A.; Struthers, Roxanne; Casken, John

    2004-01-01

    A study conducted by the University of Minnesota found that cigarettes can be purchased on American Indian–owned Internet sites for about one fifth of the price at grocery stores, making this a more convenient, lower-priced, and appealing method of purchasing cigarettes. Researchers and educators are challenged to address this new marketing ploy and to discover ways to curb rising smoking rates in American Indian communities. PMID:14759938

  6. Osage Avenue Is Burning: The Influence of Race upon Crisis Public Relations in Philadelphia.

    ERIC Educational Resources Information Center

    Bishop, Robert L.; Boles, Wendy Gotchel

    A study examined public relations aspects of the police confrontation and bombing of the revolutionary Black group, MOVE, in Philadelphia, in which 11 persons were killed, 250 were left homeless, and 61 homes were destroyed. It explored if and how race affected the crisis and whether Black media and general media were treated differently. City…

  7. Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway.

    PubMed

    Liu, Chunming; He, Xi

    2010-04-01

    A new study in Nature has identified a small molecule inhibitor for the oncogenic Wnt/beta-catenin pathway that is responsible for many human cancers. This inhibitor targets an unsuspected cellular enzyme, Tankyrase, which controls the destruction of a beta-catenin destructor.

  8. Meeting the challenge of ascites in ovarian cancer: new avenues for therapy and research

    PubMed Central

    Kipps, Emma; Tan, David S. P.; Kaye, Stan B.

    2015-01-01

    Malignant ascites presents a considerable clinical challenge to the management of ovarian cancer, but also provides a wealth of opportunities for translational research. The accessibility of ascitic fluid and its cellular components make it an excellent source of tumour tissue for the investigation of prognostic and predictive biomarkers, pharmacodynamic markers and for molecular profiling analysis. In this Opinion article, we discuss recent advances in our understanding of its pathophysiology, the development of new methods to characterize its molecular features and how these findings can be used to improve the treatment of malignant ascites, particularly in the context of ovarian cancer. PMID:23426401

  9. Dale Avenue School Early Childhood Education Center Project. Research Bulletin Volume III, No. 2, June 1973.

    ERIC Educational Resources Information Center

    Paterson Board of Education, NJ.

    Reported are results of an evaluation of the handwriting skills of first, second, and third level students who were part of an urban early childhood education project for culturally disadvantaged children in Paterson, New Jersey. Provided is a summary of A. Gesell and F. Ilg's recommendations for handwriting instruction for kindergarten through…

  10. Food Commensals as a Potential Major Avenue in Transmitting Antibiotic Resistance Genes

    DTIC Science & Technology

    2005-08-01

    eflriaxone-rcsistant Sa/luorwhll infoction acquired by a child firom eattle, N, lngl .1. AM, 342:1242-1249. 11. Gaudreau C., Gilbert H. Antimicrobial ...resistance of clinical strains of Campylobacter jcjuni subsp. jejuni isolated from 1985 to 1997 in Quebec, Canada, 1998. Anlitnicrob. Agents Chemotwiir...42:2106-210., 12. Gc B, White DG, McDermott PF, Girard W, Zhao S, Hubert S, Meng J. 2003. Antimicrobial -resistant Campylobaeier species friom retail

  11. An Avenue for Challenging Sexism: Examining the High School Sociology Classroom

    ERIC Educational Resources Information Center

    Stevens, Kaylene Mae; Martell, Christopher C.

    2016-01-01

    In this interpretative qualitative study, the researchers investigated the beliefs and practices of six high school sociology teachers in relation to the teaching of gender. Using a feminist lens, this study employed mixed methods, analyzing teacher interviews, observations, and classroom artifacts. The results showed that the teachers viewed…

  12. Oxytocin enables novelty seeking and creative performance through upregulated approach: evidence and avenues for future research.

    PubMed

    De Dreu, Carsten K W; Baas, Matthijs; Boot, Nathalie C

    2015-01-01

    Oxytocin is an evolutionary ancient hypothalamic neuropeptide well known for its role in reproduction, social bonding, and group affiliation. Recent work has linked oxytocin in humans to creative cognition--the ability to produce insights, ideas, and problem solutions that are original and potentially useful. Here we review this literature, focusing on the relationship between (1) single-nucleotide polymorphisms in the oxytocin receptor (OXTR) gene; endogenous oxytocin from blood plasma, and intranasal administration of oxytocin (vs placebo), and (2) creativity-related traits (e.g., novelty seeking, extraversion, and openness to experience), and behaviors (e.g., exploration, divergent thinking, original ideation, and problem solving). Findings are interpreted in the context of the dual pathway to creativity model and except for OXTR: (1) reveal a weak to moderate but consistent association between oxytocin and creativity, which emerges because (2) oxytocin enables the cognitive flexibility pathway more than persistent information processing. Findings can be best understood in terms of oxytocin's putative effects on dopaminergic activity and concomitant approach tendency.

  13. 78 FR 19192 - Nexiant, LLC, 2531 West Maryland Avenue, Tampa, FL 33629; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-29

    ... Export Administration Act (50 U.S.C. app. 2401-2420 (2000)) (``EAA''). Since August 21, 2001, the EAA has... Register. Issued this 22nd day of March, 2013. Bernard Kritzer, Director, Office of Exporter...

  14. 78 FR 11142 - Connor Hayden Kraegel, 19917 Spurrier Avenue, Poolesville, MD 20837; Order Denying Export Privileges

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-15

    .... 2401-2420 (2000)) (``EAA''). Since August 21, 2001, the EAA has been in lapse and the President... Order shall be published in the Federal Register. Issued this 8th day of February, 2013. Bernard...

  15. From Companion Diagnostics to Theranostics: A New Avenue for Alzheimer's Disease?

    PubMed

    Bolognesi, Maria Laura; Gandini, Annachiara; Prati, Federica; Uliassi, Elisa

    2016-09-08

    The recent literature signals a growing paradigm shift toward integrating therapeutics and diagnostics rather than developing and deploying them separately. In this gradual move toward more effective and personalized medications, companion diagnostics are an intermediate stage. The next step may be "theranostics", in which single chemical entities are developed to deliver therapy and diagnosis simultaneously. This strategy has been successfully exploited in oncology and is now emerging as a possibility for Alzheimer's disease, where its feasibility has caught the attention of researchers from industry and academia. Medicinal chemists do not yet completely understand the nuances of theranostic action and consequently have not yet developed universally validated strategies for developing theranostic clinical applications against Alzheimer's disease. However, given the emerging indications of the potentially enormous benefits that theranostics may bring to the fight against this devastating disease, further rigorous research is warranted.

  16. Beyond DOtS: avenues ahead in the management of tuberculosis.

    PubMed

    Chaudhury, Ranjit Roy; Thatte, Urmila

    2003-01-01

    India has almost 30% of the global burden of tuberculosis (TB)--one person dies of the disease every minute in our country. India has mounted the second-largest DOTS programme in the world to control this disease. However, DOTS has its limitations and newer approaches have been developed over the years to overcome the global burden of tuberculosis. Problems with health facilities, patients, drugs and the disease itself constitute some of the hurdles in the implementation of the DOTS programme. In an attempt to go beyond DOTS, the WHO launched the 'Stop TB Initiative' in 1988. Against the background of irrational antituberculosis drug use, which contributes to increasing drug resistance, the effective involvement of private healthcare providers is imperative to achieve better geographical and patient coverage for the implementation of DOTS. The WHO is currently addressing the issue of involving private practitioners in tuberculosis control in a programme called Public-Private Mix DOTS (PPM DOTS). The Stop TB Initiative is also active in the area of dual infection with HIV and tuberculosis, and the initiatives that have been taken in this area include 'ProTEST', community contribution to tuberculosis care, and development and dissemination of training materials and guidelines. The DOTS-Plus strategy for the management of multidrug resistant (MDR)-TB and the establishment of the Green Light Committee to review project applications in this area are initiatives taken to curb the problem of drug resistance in tuberculosis. Even decades after the introduction of the DOTS strategy, much needs to be done to expand the services to the entire population; it is now essential to develop strategies that go beyond DOTS.

  17. Derivative with two fractional orders: A new avenue of investigation toward revolution in fractional calculus

    NASA Astrophysics Data System (ADS)

    Atangana, Abdon

    2016-10-01

    In order to describe more complex problems using the concept of fractional derivatives, we introduce in this paper the concept of fractional derivatives with orders. The new definitions are based upon the concept of power law together with the generalized Mittag-Leffler function. The first order is included in the power law function and the second one is in the generalized Mittag-Leffler function. Each order therefore plays an important role while modeling, for instance, problems with two layers with different properties. This is the case, for instance, in thermal science for a reaction diffusion within a media with two different layers with different properties. Another case is that of groundwater flowing within an aquifer where geological formation is formed with two layers with different properties. The paper presents new fractional operators that will open new doors for research and investigations in modeling real world problems. Some useful properties of the new operators are presented, in particular their relationship with existing integral transforms, namely the Laplace, Sumudu, Mellin and Fourier transforms. The numerical approximation of the new fractional operators are presented. We apply the new fractional operators on the model of groundwater plume with degradation and limited sorption and solve the new model numerically with some numerical simulations. The numerical simulation leaves no doubt in believing that the new fractional operators are powerfull mathematical tools able to portray complexes real world problems.

  18. An Alternative Avenue to Teacher Certification: A Cost Analysis of the Pathways to Teaching Careers Program.

    ERIC Educational Resources Information Center

    Rice, Jennifer King; Brent, Brian O.

    2002-01-01

    Analyzes cost effectiveness of the Pathways to Teaching Careers, a program that supports an alternative route to university-based teacher certification primarily for noncertified teachers, paraprofessionals, and Peace Corps volunteers. (PKP)

  19. Springfield Avenue Community School, Newark, New Jersey: Model Programs. Childhood Education.

    ERIC Educational Resources Information Center

    American Institutes for Research in the Behavioral Sciences, Palo Alto, CA.

    Prepared for a White House Conference on Children (December 1970), this report describes a Newark, New Jersey program which began with day care for young children and grew into an educational continuum beginning in some cases at the age of 18 months and running through the fourth grade. The program is considered remarkable for the amount of parent…

  20. Brief Communication: Future avenues for permafrost science from the perspective of early career researchers

    NASA Astrophysics Data System (ADS)

    Fritz, M.; Deshpande, B. N.; Bouchard, F.; Högström, E.; Malenfant-Lepage, J.; Morgenstern, A.; Nieuwendam, A.; Oliva, M.; Paquette, M.; Rudy, A. C. A.; Siewert, M. B.; Sjöberg, Y.; Weege, S.

    2015-08-01

    Accelerating climate change and increased economic and environmental interests in permafrost-affected regions have resulted in an acute need for more directed permafrost research. In June 2014, 88 early career researchers convened to identify future priorities for permafrost research. This multidisciplinary forum concluded that five research topics deserve greatest attention: permafrost landscape dynamics, permafrost thermal modeling, integration of traditional knowledge, spatial distribution of ground ice, and engineering issues. These topics underline the need for integrated research across a spectrum of permafrost-related domains and constitute a contribution to the Third International Conference on Arctic Research Planning (ICARP III).

  1. Brief Communication: Future avenues for permafrost science from the perspective of early career researchers

    NASA Astrophysics Data System (ADS)

    Fritz, M.; Deshpande, B. N.; Bouchard, F.; Högtröm, E.; Lepage, J.; Morgenstern, A.; Nieuwendam, A.; Oliva, M.; Paquette, M.; Rudy, A. C. A.; Siewert, M. B.; Sjöberg, Y.; Weege, S.

    2015-02-01

    Accelerating climate change and increased economic and environmental interest in permafrost-affected regions have resulted in an acute need for more directed permafrost research. In June 2014, 88 early career researchers convened to identify future priorities for permafrost research. This multidisciplinary forum concluded that five research topics deserve greatest attention: permafrost landscape dynamics; permafrost thermal modelling; integration of traditional knowledge; spatial analysis of permafrost types and vulnerability; and engineering issues. These topics underline the need for integrated research across a spectrum of permafrost-related domains and constitute a contribution to the Third International Conference on Arctic Research Planning (ICARP III).

  2. Rapid synthesis of barium titanate microcubes using composite-hydroxides-mediated avenue

    SciTech Connect

    He, Xi; Ouyang, Jing Jin, Jiao; Yang, Huaming

    2014-04-01

    Highlights: • Barium titanate oxides microcubes can be synthesized within 1 min. • Composite-hydroxides-mediated strategy provided a possible large scale production. • BST obtained in the strategy showed fairly good crystallinity and tetragonality. - Abstract: This paper reports the rapid synthesis of barium titanate (BaTiO{sub 3}, BTO) microcubes via composite-hydroxides-mediated reaction within 1 min. X-ray diffraction (XRD), scanning electron microscopy (SEM) and energy dispersion spectrum (EDS) results confirmed both cubic and tetragonal lattices in the sample and the uniform microcubes with an average size of 1 μm. Ultraviolet–visible (UV–vis) spectrum indicated that the band gap of the BTO powder was 3.05 eV. Ferroelectric polarization vs. electric field (P–E) tests showed that the ferroelectric domains had formed in the as-synthesized BTO microcubes and sintered ceramics. BTO ceramics sintered at 1100 °C for 3 h showed fairly good tetragonality and possessed a maximum polarization of 0.21 μC/cm{sup 2}, indicating that the sintering temperature for the BTO powders prepared via this method was relatively low. The process and equipment reported herein provided a potential method for the rapid synthesis of titanate based perovskites.

  3. Exciting new advances in neuro-oncology: the avenue to a cure for malignant glioma.

    PubMed

    Van Meir, Erwin G; Hadjipanayis, Costas G; Norden, Andrew D; Shu, Hui-Kuo; Wen, Patrick Y; Olson, Jeffrey J

    2010-01-01

    Malignant gliomas are the most common and deadly brain tumors. Nevertheless, survival for patients with glioblastoma, the most aggressive glioma, although individually variable, has improved from an average of 10 months to 14 months after diagnosis in the last 5 years due to improvements in the standard of care. Radiotherapy has been of key importance to the treatment of these lesions for decades, and the ability to focus the beam and tailor it to the irregular contours of brain tumors and minimize the dose to nearby critical structures with intensity-modulated or image-guided techniques has improved greatly. Temozolomide, an alkylating agent with simple oral administration and a favorable toxicity profile, is used in conjunction with and after radiotherapy. Newer surgical techniques, such as fluorescence-guided resection and neuroendoscopic approaches, have become important in the management of malignant gliomas. Furthermore, new discoveries are being made in basic and translational research, which are likely to improve this situation further in the next 10 years. These include agents that block 1 or more of the disordered tumor proliferation signaling pathways, and that overcome resistance to already existing treatments. Targeted therapies such as antiangiogenic therapy with antivascular endothelial growth factor antibodies (bevacizumab) are finding their way into clinical practice. Large-scale research efforts are ongoing to provide a comprehensive understanding of all the genetic alterations and gene expression changes underlying glioma formation. These have already refined the classification of glioblastoma into 4 distinct molecular entities that may lead to different treatment regimens. The role of cancer stem-like cells is another area of active investigation. There is definite hope that by 2020, new cocktails of drugs will be available to target the key molecular pathways involved in gliomas and reduce their mortality and morbidity, a positive development for patients, their families, and medical professionals alike.

  4. DOE ZERH Case Study: BrightLeaf Homes, McCormick Avenue, Brookfield, IL

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning production home in the cold climate that got a HERS 38 without PV, with staggered 2x4 studs every 8”on a 2x6 plate with dense-packed R-25 cellulose, basement with 3” XPS exterior and 2: XPS under slab; a vented attic with spray foam top plates and R-60 blown cellulose; 96% AFUE furnace, 14 SEER AC, plus fresh air intake.

  5. Reaching adolescent girls through social networking: a new avenue for smoking prevention messages.

    PubMed

    Struik, Laura Louise; Bottorff, Joan L; Jung, Mary; Budgen, Claire

    2012-09-01

    Because adolescent girls are being targeted on social networking sites by the tobacco industry, new online tobacco control (TC) initiatives are needed. The purpose of this interpretive descriptive study was to explore adolescent girls' perspectives on the use of social networking sites to deliver TC messages targeting young women. Focus groups were conducted with 17 girls aged 16 to 19. Seven TC messages were provided for evaluation and as context for discussion about the delivery of TC messages on social networking sites. Data were analyzed for themes, which included concerns about the effectiveness of current TC messages and the stereotypical representations of gender, factors perceived to influence the effectiveness of TC messages on social networking sites, and suggestions for enhancing the effectiveness of TC messages placed on social networking sites. Endorsement of TC messaging on social networking sites suggests that this medium is an untapped resource for smoking prevention.

  6. Molecular manipulation of G-protein-coupled receptors: a new avenue into drug discovery.

    PubMed

    Sautel, M; Milligan, G

    2000-09-01

    During the past 10 years or so, associated with the introduction of molecular biology techniques to G protein-coupled receptor (GPCR) research, outstanding progress has been made in understanding the mechanisms of action of these key proteins and their physiological functions. in-vivo manipulation of levels of GPCRs using transgenic and gene knock-out approaches have been particularly successful in assessing the roles of specific GPCRs in animal physiology. Drug discovery is aiming to produce highly specific compounds based on subtle definition of receptor subtypes which can best be studied using heterologous expression of wild type or mutated forms of cDNA or genes encoding these proteins. Furthermore, new therapeutic opportunities may be provided by investigation of orphan receptors, the natural ligands for which remain unidentified. Some human diseases have been shown to be associated with rare mutations of GPCRs and the possibility that widely distributed polymorphisms in GPCR genes may allow selective therapeutic strategies for population subgroups is driving the development of the science of pharmacogenetics.

  7. Public avenues to private spaces: Democratic politics and the control of automobile pollution

    SciTech Connect

    Rajan, S.C.

    1994-01-01

    Automobile pollution policy is an institutional concern because it represents the political problem of addressing one of the ill-effects of mass driving within urban regions. In the United States, where automobility is most pervasive, the social and cultural institutions that make driving an ineluctable feature of everyday life tend to be taken for granted. On the one hand, an idealogy of individualism appears to forestall critical discussion on these aspects within civil society; on the other, reliance on technological solutions and a prevailing culture of interest-group politics help contract the space for normative reasoning within policy discourse. Ironically, though, the more people drive, the more [open quotes]auto[close quotes]-inflicted the problems of air pollution, and the more likely it is that the contradictions of these non-participatory and technocratic forms could generate crises of policy. The predicament of automobile pollution policy then comprises a paralysis in the state's continued capacity to response to what it perceives to be a double-gesture made by its citizens; they demand clean air but are unwilling to take responsibility for achieving it, especially if it involves setting limits on automobile usage. Using both theoretical arguments and empirical and historical evidence from California, this dissertation argues that official readings of automobile pollution control are constricted because they rely on an individualist metaphor which only generates elaborate techniques of risk management in response, thus moving away from a shared public effort towards normative discourse. Yet, it its also critical of approaches that would shift the blame to individual motorists and their vehicles by implying that the problem arises from the employment of a few [open quotes]gross emitters[close quotes] that need to be selectively targeted.

  8. Pointing the Way: Possible Avenues of Development in the Field of Mathematics Education

    ERIC Educational Resources Information Center

    Ross, Vicki

    2005-01-01

    An essay review of "Assessing Children's Mathematical Knowledge: Social Class, Sex and Problem Solving" by Barry Cooper and Mirad Dunne, Philadelphia: Open University Press, 2000; "Talking Mathematics in School: Studies in Teaching and Learning," Ed. Magdalene Lampert and Merrie L. Blunk, New York: Teachers College Press, 1998; "Reconstructing…

  9. Retinitis pigmentosa-associated cystoid macular oedema: pathogenesis and avenues of intervention

    PubMed Central

    Strong, S; Liew, G; Michaelides, M

    2017-01-01

    Hereditary retinal diseases are now the leading cause of blindness certification in the working age population (age 16–64 years) in England and Wales, of which retinitis pigmentosa (RP) is the most common disorder. RP may be complicated by cystoid macular oedema (CMO), causing a reduction of central vision. The underlying pathogenesis of RP-associated CMO (RP-CMO) remains uncertain, however, several mechanisms have been proposed, including: (1) breakdown of the blood-retinal barrier, (2) failure (or dysfunction) of the pumping mechanism in the retinal pigment epithelial, (3) Müller cell oedema and dysfunction, (4) antiretinal antibodies and (5) vitreous traction. There are limited data on efficacy of treatments for RP-CMO. Treatments attempted to date include oral and topical carbonic anhydrase inhibitors, oral, topical, intravitreal and periocular steroids, topical non-steroidal anti-inflammatory medications, photocoagulation, vitrectomy with internal limiting membrane peel, oral lutein and intravitreal antivascular endothelial growth factor injections. This review summarises the evidence supporting these treatment modalities. Successful management of RP-CMO should aim to improve both quality and quantity of vision in the short term and may also slow central vision loss over time. PMID:27913439

  10. Education Research: New Avenues for Video Pedagogy and Feedback in Teacher Education.

    ERIC Educational Resources Information Center

    Tochon, Francois Victor

    2001-01-01

    Surveys the role of video feedback in light of a new, integrated concept in teacher education called education research. Shows how shared reflection was stimulated during language teacher education to link theory with practice. Situations were created that allowed for reflective practice on the semiosis of action. (Author/VWL)

  11. Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo.

    PubMed

    Biller, Joshua R; Mitchell, Deborah G; Tseytlin, Mark; Elajaili, Hanan; Rinard, George A; Quine, Richard W; Eaton, Sandra S; Eaton, Gareth R

    2016-09-26

    We demonstrate a superior method of 2D spectral-spatial imaging of stable radical reporter molecules at 250 MHz using rapid-scan electron-paramagnetic-resonance (RS-EPR), which can provide quantitative information under in vivo conditions on oxygen concentration, pH, redox status and concentration of signaling molecules (i.e., OH(•), NO(•)). The RS-EPR technique has a higher sensitivity, improved spatial resolution (1 mm), and shorter acquisition time in comparison to the standard continuous wave (CW) technique. A variety of phantom configurations have been tested, with spatial resolution varying from 1 to 6 mm, and spectral width of the reporter molecules ranging from 16 µT (160 mG) to 5 mT (50 G). A cross-loop bimodal resonator decouples excitation and detection, reducing the noise, while the rapid scan effect allows more power to be input to the spin system before saturation, increasing the EPR signal. This leads to a substantially higher signal-to-noise ratio than in conventional CW EPR experiments.

  12. Long Circulating Lectin Conjugated Paclitaxel Loaded Magnetic Nanoparticles: A New Theranostic Avenue for Leukemia Therapy

    PubMed Central

    Singh, Abhalaxmi; Dilnawaz, Fahima; Sahoo, Sanjeeb Kumar

    2011-01-01

    Amongst all leukemias, Bcr-Abl positive chronic myelogenous leukemia (CML) confers resistance to native drug due to multi drug resistance and also resistance to p53 and fas ligand pathways. In the present study, we have investigated the efficacy of microtubule stabilizing paclitaxel loaded magnetic nanoparticles (pac-MNPs) to ascertain its cytotoxic effect on Bcr-Abl positive K562 cells. For active targeted therapy, pac-MNPs were functionalized with lectin glycoprotein which resulted in higher cellular uptake and lower IC50 value suggesting the efficacy of targeted delivery of paclitaxel. Both pac-MNPs and lectin conjugated pac-MNPs have a prolonged circulation time in serum suggesting increased bioavailability and therapeutics index of paclitaxel in vivo. Further, the molecular mechanism pertaining to pac-induced cytotoxicity was analyzed by studying the involvement of different apoptotic pathway proteins by immunoblotting and quantitative PCR. Our study revealed simultaneous activation of JNK pathway leading to Bcr-Abl instability and the extrinsic apoptotic pathway after pac-MNPs treatment in two Bcr-Abl positive cell lines. In addition, the MRI data suggested the potential application of MNPs as imaging agent. Thus our in vitro and in vivo results strongly suggested the pac-MNPs as a future prospective theranostic tool for leukemia therapy. PMID:22110595

  13. Angiotensin II Receptor Blocker Neprilysin Inhibitor (ARNI): New Avenues in Cardiovascular Therapy.

    PubMed

    Volpe, M; Tocci, G; Battistoni, A; Rubattu, S

    2015-09-01

    The burden of cardiovascular disease (CVD) is continuously and progressively raising worldwide. Essential hypertension is a major driver of cardiovascular events, including coronary artery disease, myocardial infarction, ischemic stroke and congestive heart failure. This latter may represent the final common pathway of different cardiovascular diseases, and it is often mediated by progressive uncontrolled hypertension. Despite solid advantages derived from effective and sustained blood pressure control, and the widespread availability of effective antihypertensive medications, the vast majority of the more than 1 billion hypertensive patients worldwide continue to have uncontrolled hypertension. Among various factors that may be involved, the abnormal activation of neurohormonal systems is one consistent feature throughout the continuum of cardiovascular diseases. These systems may initiate biologically meaningful "injury responses". However, their sustained chronic overactivity often may induce and maintain the progression from hypertension towards congestive heart failure. The renin-angiotensin-aldosteron system, the sympathetic nervous system and the endothelin system are major neurohormonal stressor systems that are not only able to elevate blood pressure levels by retaining water and sodium, but also to play a role in the pathophysiology of cardiovascular diseases. More recently, the angiotensin receptor neprilysin inhibitor (ARNI) represents a favourable approach to inhibit neutral endopeptidase (NEP) and suppress the RAAS via blockade of the AT1 receptors, without the increased risk of angioedema. LCZ696, the first-in-class ARNI, has already demonstrated BP lowering efficacy in patients with hypertension, in particular with respect to systolic blood pressure levels, improved cardiac biomarkers, cardiac remodelling and prognosis in patients with heart failure. This manuscript will briefly overview the main pathophysiological and therapeutic aspects of ARNI in the clinical management of hypertension and heart failure.

  14. Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity

    PubMed Central

    Beyrau, Martina; Bodkin, Jennifer Victoria; Nourshargh, Sussan

    2012-01-01

    Leucocytes form the principal cellular components of immunity and inflammation, existing as multiple subsets defined by distinct phenotypic and functional profiles. To date, this has most notably been documented for lymphocytes and monocytes. In contrast, as neutrophils are traditionally considered, to be short-lived, terminally differentiated cells that do not re-circulate, the potential existence of distinct neutrophil subsets with functional and phenotypic heterogeneity has not been widely considered or explored. A growing body of evidence is now challenging this scenario, and there is significant evidence for the existence of different neutrophil subsets under both physiological and pathological conditions. This review will summarize the key findings that have triggered a renewed interest in neutrophil phenotypic changes, both in terms of functional implications and consequences within disease models. Special emphasis will be placed on the potential pro- and anti-inflammatory roles of neutrophil subsets, as indicated by the recent works in models of ischaemia–reperfusion injury, trauma, cancer and sepsis. PMID:23226600

  15. A microbial avenue to cell cycle control in the plant superkingdom.

    PubMed

    Tulin, Frej; Cross, Frederick R

    2014-10-01

    Research in yeast and animals has resulted in a well-supported consensus model for eukaryotic cell cycle control. The fit of this model to early diverging eukaryotes, such as the plant kingdom, remains unclear. Using the green alga Chlamydomonas reinhardtii, we developed an efficient pipeline, incorporating robotics, semiautomated image analysis, and deep sequencing, to molecularly identify >50 genes, mostly conserved in higher plants, specifically required for cell division but not cell growth. Mutated genes include the cyclin-dependent kinases CDKA (resembling yeast and animal Cdk1) and the plant-specific CDKB. The Chlamydomonas cell cycle consists of a long G1 during which cells can grow >10-fold, followed by multiple rapid cycles of DNA replication and segregation. CDKA and CDKB execute nonoverlapping functions: CDKA promotes transition between G1 and entry into the division cycle, while CDKB is essential specifically for spindle formation and nuclear division, but not for DNA replication, once CDKA-dependent initiation has occurred. The anaphase-promoting complex is required for similar steps in the Chlamydomonas cell cycle as in Opisthokonts; however, the spindle assembly checkpoint, which targets the APC in Opisthokonts, appears severely attenuated in Chlamydomonas, based on analysis of mutants affecting microtubule function. This approach allows unbiased integration of the consensus cell cycle control model with innovations specific to the plant lineage.

  16. Psychoneuroimmunology: new avenues of research for the twenty-first century.

    PubMed

    Prolo, Paolo; Chiappelli, Francesco; Fiorucci, Adriano; Dovio, Andrea; Sartori, Maria Luisa; Angeli, Alberto

    2002-06-01

    Psychoneuroimmunology (PNI) investigates the relations between the psychophysiological and immunophysiological dimensions of living beings. PNI brings together researchers in a number of scientific and medical disciplines, including psychology, the neurosciences, immunology, physiology, pharmacology, psychiatry, behavioral medicine, infectious diseases, and rheumatology. All are scientists with profound interest in interactions between the nervous and immune systems, and the relation between behavior and health. Despite the variety in domains and approaches to research, the outcome common to all research endeavors is the discovery of new information, of uncovered facts, of novel evidence, which contributes to the continuing generation of knowledge. In this paper we discuss psychoneuroimmune aspects of some conditions that are not routinely immediately associated with immunity, such as the condition of being the caregiver of somebody suffering from dementia; the effect on the brain-body modulations of aluminum, a metal that is not a component of the human body; and insomnia, a fairly common but disturbing disease, that even today lacks an effectual treatment.

  17. Exploring symmetry as an avenue to the computational design of large protein domains.

    PubMed

    Fortenberry, Carie; Bowman, Elizabeth Anne; Proffitt, Will; Dorr, Brent; Combs, Steven; Harp, Joel; Mizoue, Laura; Meiler, Jens

    2011-11-16

    It has been demonstrated previously that symmetric, homodimeric proteins are energetically favored, which explains their abundance in nature. It has been proposed that such symmetric homodimers underwent gene duplication and fusion to evolve into protein topologies that have a symmetric arrangement of secondary structure elements--"symmetric superfolds". Here, the ROSETTA protein design software was used to computationally engineer a perfectly symmetric variant of imidazole glycerol phosphate synthase and its corresponding symmetric homodimer. The new protein, termed FLR, adopts the symmetric (βα)(8) TIM-barrel superfold. The protein is soluble and monomeric and exhibits two-fold symmetry not only in the arrangement of secondary structure elements but also in sequence and at atomic detail, as verified by crystallography. When cut in half, FLR dimerizes readily to form the symmetric homodimer. The successful computational design of FLR demonstrates progress in our understanding of the underlying principles of protein stability and presents an attractive strategy for the in silico construction of larger protein domains from smaller pieces.

  18. Molecular biology of adenocarcinoma of the pancreatic duct, current state and future therapeutic avenues.

    PubMed

    Abbas, Saleh

    2013-06-01

    Pancreatic adenocarcinoma is a lethal disease; currently surgery offers five years survival of less than 5%. Any improvement in the outcome is likely to be through novel therapeutic agents that will target the genetic machinery of the cell. Knowledge of genetic alterations in the process of carcinogenesis is expanding rapidly, the targeted therapy, however, is progressing slowly. Pancreatic adenocarcinoma displays a variety of molecular changes that evolve exponentially with time and lend the cancer cells their ability not only to survive, but also to invade the surrounding tissues and metastasise to distant sites. These changes involve genetic alteration in oncogenes, cancer suppressor genes, changes in cell cycle, pathways of apoptosis and also changes in epithelial to mesenchymal transition. Monotherapeutic targeted agents seem(s) to have limited effect on cancer cells. The near future is likely to show an improvement in the treatment outcome, which is likely to be a result of the combination of targeted agents with surgery and chemotherapy.

  19. MeCP2 and Rett syndrome: reversibility and potential avenues for therapy.

    PubMed

    Gadalla, Kamal K E; Bailey, Mark E S; Cobb, Stuart R

    2011-10-01

    Mutations in the X-linked gene MECP2 (methyl CpG-binding protein 2) are the primary cause of the neurodevelopmental disorder RTT (Rett syndrome), and are also implicated in other neurological conditions. The expression product of this gene, MeCP2, is a widely expressed nuclear protein, especially abundant in mature neurons of the CNS (central nervous system). The major recognized consequences of MECP2 mutation occur in the CNS, but there is growing awareness of peripheral effects contributing to the full RTT phenotype. MeCP2 is classically considered to act as a DNA methylation-dependent transcriptional repressor, but may have additional roles in regulating gene expression and chromatin structure. Knocking out Mecp2 function in mice recapitulates many of the overt neurological features seen in RTT patients, and the characteristic postnatally delayed onset of symptoms is accompanied by aberrant neuronal morphology and deficits in synaptic physiology. Evidence that reactivation of endogenous Mecp2 in mutant mice, even at adult stages, can reverse aspects of RTT-like pathology and result in apparently functionally mature neurons has provided renewed hope for patients, but has also provoked discussion about traditional boundaries between neurodevelopmental disorders and those involving dysfunction at later stages. In the present paper we review the neurobiology of MeCP2 and consider the various genetic (including gene therapy), pharmacological and environmental interventions that have been, and could be, developed to attempt phenotypic rescue in RTT. Such approaches are already providing valuable insights into the potential tractability of RTT and related conditions, and are useful pointers for the development of future therapeutic strategies.

  20. Genomic editing opens new avenues for zebrafish as a model for neurodegeneration.

    PubMed

    Schmid, Bettina; Haass, Christian

    2013-11-01

    Zebrafish has become a popular model organism to study human diseases. We will highlight the advantages and limitations of zebrafish as a model organism to study neurodegenerative diseases and introduce zinc finger nucleases, transcription activator-like effector nucleases, and the recently established clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeat-associated system for genome editing. The efficiency of the novel genome editing tools now greatly facilitates knock-out and, importantly, also makes knock-in approaches feasible in zebrafish. Genome editing in zebrafish avoids unspecific phenotypes caused by off-target effects and toxicity as frequently seen in conventional knock-down approaches.

  1. Human Term Placental Cells: Phenotype, Properties and New Avenues in Regenerative Medicine

    PubMed Central

    Caruso, Maddalena; Evangelista, Marco; Parolini, Ornella

    2012-01-01

    The human placenta has long been the subject of scientific interest due to the important roles which it performs during pregnancy in sustaining the fetus and maintaining fetomaternal tolerance. More recently, however, researchers have begun to investigate the possibility that the placenta’s utility may extend beyond fetal development to act as a source of cells with clinically relevant properties. Indeed, several groups have reported the isolation of cells from different placental regions which display both multilineage differentiation potential and immunomodulatory properties in vitro. Furthermore, these cells have also been shown to secrete soluble factors involved in pathophysiological processes that may aid tissue repair. Cells with such features will clearly find application in the field of regenerative medicine for the repair/regeneration of damaged or diseased tissues or organs. In line with these promising findings, several preclinical and clinical studies conducted to date argue in strong favor of the therapeutic utility of placenta-derived cells for the treatment of several diseases. Although much work remains to be conducted in order to fully understand the properties of placental cells and the mechanisms which underlie their beneficial effects in vivo, data reported to date nonetheless provide compelling evidence in support of the placenta as a cell source for use in regenerative medicine. PMID:24551761

  2. Participation in Field Learning and Teaching Opportunities: Avenues to Research and Publication

    ERIC Educational Resources Information Center

    Albert, Donald; Strait, John; Fujimoto-Strait, Ava

    2016-01-01

    Field experiences continue to be a hallmark of a geographer's education and, for that matter, reeducation, as we all strive to remain current in the real world. Academic geographers beginning their ascent towards tenure and promotion might consider augmenting their portfolios with materials emerging from field teaching and learning activities.

  3. Image of Women in Advertisements: A Preliminary Study of Avenues for Change.

    ERIC Educational Resources Information Center

    Butler-Paisley, Matilda, Ed.; And Others

    The Center for Research on Women (CROW) at Stanford University along with the Communication Department, the Psychology Department, and the School of Education conducted a study on the image of women in advertising and suggested ways to improve women's image in the advertising media. With the objective of sponsoring some alternatives to expedite…

  4. Composite Avenue beyond the Standard Model ---Legacy of Sakata in LHC Era---

    NASA Astrophysics Data System (ADS)

    Yamawaki, K.

    Higgs boson may be a composite particle as Sakata vigorously looked for never-ending substructures of Nature. He proposed the Sakata model for hadrons, which was the prototype of the quark model and thus lauched the last Revolution in particle physics continued all the way up to Kabayashi-Maskawa work which completed the Standard Model today. Inspired by Sakata's spirit we shall discuss composite Higgs boson in various models of our own for the dynamical symmetry breaking with large anomalous dimension: The techni-dilaton in the walking technicolor (WTC) with gamma_m ≃ 1, the bar t t composite (``top-Higgs'') in the top-quark condensate model with gamma_m ≃ 2, and their variants in the models with 1 < gamma_m < 2 (strong ETC Technicolor, etc.). Among others we will focus on WTC which has an approximate scale symmetry in the region relevant to the dynamical mass generation. Such a conformal gauge dynamics is characterized by the essential singularity scaling, breakdown of the Ginzburg-Landau/Gell-Mann-Levy effective theory, and also by a large anomalous dimension gamma_m = 1. In contrast to the folklore that Technicolor is a ``Higgsless theory'', there exists a composite Higgs, techni-dilaton, in the WTC as a composite pseudo Nambu-Goldstone boson associated with the spontaneously broken (approximate) scale symmetry, with its mass only arising from the (nonperturbative) scale anomaly and hence being much smaller than those of other techni-hadrons. The techni-dilaton has a mass typically of order 500-600 GeV and can be discovered at LHC. We shall also touch upon the endeavor to discover WTC on the lattice.

  5. Binding of [alpha, alpha]-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design

    SciTech Connect

    Ilies, Monica; Di Costanzo, Luigi; Dowling, Daniel P.; Thorn, Katherine J.; Christianson, David W.

    2011-10-21

    Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral malaria. Accordingly, arginase inhibitors may be therapeutically useful. Continuing our efforts to expand the chemical space of arginase inhibitor design and inspired by the binding of 2-(difluoromethyl)-L-ornithine to human arginase I, we now report the first study of the binding of {alpha},{alpha}-disubstituted amino acids to arginase. Specifically, we report the design, synthesis, and assay of racemic 2-amino-6-borono-2-methylhexanoic acid and racemic 2-amino-6-borono-2-(difluoromethyl)hexanoic acid. X-ray crystal structures of human arginase I and Plasmodium falciparum arginase complexed with these inhibitors reveal the exclusive binding of the L-stereoisomer; the additional {alpha}-substituent of each inhibitor is readily accommodated and makes new intermolecular interactions in the outer active site of each enzyme. Therefore, this work highlights a new region of the protein surface that can be targeted for additional affinity interactions, as well as the first comparative structural insights on inhibitor discrimination between a human and a parasitic arginase.

  6. Age-associated Cognitive Decline: Insights into Molecular Switches and Recovery Avenues

    PubMed Central

    Konar, Arpita; Singh, Padmanabh; Thakur, Mahendra K.

    2016-01-01

    Age-associated cognitive decline is an inevitable phenomenon that predisposes individuals for neurological and psychiatric disorders eventually affecting the quality of life. Scientists have endeavored to identify the key molecular switches that drive cognitive decline with advancing age. These newly identified molecules are then targeted as recovery of cognitive aging and related disorders. Cognitive decline during aging is multi-factorial and amongst several factors influencing this trajectory, gene expression changes are pivotal. Identifying these genes would elucidate the neurobiological underpinnings as well as offer clues that make certain individuals resilient to withstand the inevitable age-related deteriorations. Our laboratory has focused on this aspect and investigated a wide spectrum of genes involved in crucial brain functions that attribute to senescence induced cognitive deficits. We have recently identified master switches in the epigenome regulating gene expression alteration during brain aging. Interestingly, these factors when manipulated by chemical or genetic strategies successfully reverse the age-related cognitive impairments. In the present article, we review findings from our laboratory and others combined with supporting literary evidences on molecular switches of brain aging and their potential as recovery targets. PMID:27114845

  7. Grassland-cropping rotations: An avenue for agricultural diversification to reconcile high production with environmental quality

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity...

  8. Investigational drugs for treatment use: an avenue of hope for minority populations.

    PubMed Central

    Veiga, R. V.; Reid, C. A.

    1989-01-01

    The Food and Drug Administration in its efforts to facilitate the drug approval process so that promising treatments may be offered to seriously ill or dying patients has established an innovative regulation, commonly known as the Treatment Investigational New Drugs (TIND). The benefits of this new policy should prove to be particularly appealing to black Americans. Traditionally blacks, due to numerous social, political, economic, and cultural factors, have had the poorest health status of any other population in the United States. The implementation of strategies to eradicate such factors will ultimately provide considerable improvement of the health status of blacks. Until then, the utilization of the TIND may prove to be one of the most significant influences in the advancement of our health care. Barriers to the use of the TIND regulation in the black community must be addressed as well. PMID:2664195

  9. The Madison Avenue Effect: How drug presentation style influences adherence and outcome in patients with asthma

    PubMed Central

    Clerisme-Beaty, Emmanuelle M; Bartlett, Susan J; Teague, W. Gerald; Lima, John; Irvin, Charles G; Cohen, Rubin; Castro, Mario; Wise, Robert A; Rand, Cynthia S

    2010-01-01

    Background Little is known about how drug presentation influences medication adherence. Objective Examine the effect of an educational program aimed at increasing expectations of treatment benefit on medication adherence. Methods Data are analyzed from 99 participants who underwent electronic drug monitoring during TAPE (Trial of Asthma Patient Education), a randomized placebo-controlled multi-center trial. Participants with suboptimally-controlled asthma were randomized to placebo or montelukast in conjunction with a presentation mode that was either neutral or designed to increase outcome expectancy. Adherence was monitored electronically over 4 weeks, and was defined as ≥ 80% use of prescribed doses. Outcome expectancy, peak expiratory flow, pre-bronchodilator forced expiratory volume, asthma control (ACQ), and asthma-related quality of life were assessed at baseline and at the 4-week follow-up. Results Average electronic medication adherence was 69.9%. There was a significant interaction between presentation mode and drug assignment, with participants in the enhanced/montelukast group having a higher change in outcome expectancy (Δ 2.1 points, p < 0.001) and better medication adherence (odds ratio 4.0, CI 1.1, 14.3) compared to those in the neutral/placebo group. There was no difference in asthma symptoms, quality of life, or clinical outcomes based on presentation mode. Rather, increased outcome expectancy was associated with modest improvements in asthma symptoms after adjusting for presentation mode, drug assignment, and medication adherence. Conclusion The use of an enhanced presentation aimed at increasing outcome expectancy may lead to improved medication adherence. PMID:21281871

  10. Binding of α,α-disubstituted amino acids to arginase suggests new avenues for inhibitor design.

    PubMed

    Ilies, Monica; Di Costanzo, Luigi; Dowling, Daniel P; Thorn, Katherine J; Christianson, David W

    2011-08-11

    Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral malaria. Accordingly, arginase inhibitors may be therapeutically useful. Continuing our efforts to expand the chemical space of arginase inhibitor design and inspired by the binding of 2-(difluoromethyl)-L-ornithine to human arginase I, we now report the first study of the binding of α,α-disubstituted amino acids to arginase. Specifically, we report the design, synthesis, and assay of racemic 2-amino-6-borono-2-methylhexanoic acid and racemic 2-amino-6-borono-2-(difluoromethyl)hexanoic acid. X-ray crystal structures of human arginase I and Plasmodium falciparum arginase complexed with these inhibitors reveal the exclusive binding of the L-stereoisomer; the additional α-substituent of each inhibitor is readily accommodated and makes new intermolecular interactions in the outer active site of each enzyme. Therefore, this work highlights a new region of the protein surface that can be targeted for additional affinity interactions, as well as the first comparative structural insights on inhibitor discrimination between a human and a parasitic arginase.

  11. Tethers in space: Birth and growth of a new avenue to space utilization

    NASA Technical Reports Server (NTRS)

    Vontiesenhausen, G.

    1984-01-01

    The evolution of the ideas of tether applications in space are traced from its origin in the last century past a dormant period of sixty-five years to the mid-seventies. At that time as a consequence of major revival efforts, NASA entered into serious investigations of the theoretical and practical feasibility of a large number of tethered concepts in space. These efforts culminated in the establishment of the Tethered Satellite System Project now at NASA in the advanced development phase. Extensive planning efforts are described, first, through a Tether Applications in Space Workshop which generated additional concepts and provided overall assessments and recommendations to NASA, and then through a NASA inter-center Tether Applications in Space Task Group which generated a four year program plan in the areas of further studies, technology, work and science and applications of tethers in space. An outlook into the future of tether applications that approaches some of the goals of the early visionaries is offered.

  12. Co-learning facilitates memory in mice: a new avenue in social neuroscience.

    PubMed

    Lipina, Tatiana V; Roder, John C

    2013-01-01

    Social context affects brain function but our understanding of its neurobiology is at an early stage. The mere presence of one individual can alter the cognitive capacities of another and social learning has been demonstrated in many species, including the mouse. We asked several questions: 1. How can active engagement of two familiar mice in the same learning activity (co-learning) alter their memory? 2. Under which environmental conditions (aversive vs non-aversive) can we expect the memory to be enhanced, impaired, or not affected? 3. Can a genetic factor modify the co-learning effect on memory? More specifically, can co-learning correct memory deficits in autistic-like BTBR inbred mice with deficient sociability? We demonstrated that pairs of familiar inbred mice of the same or different genotypes (C57BL/6J and BTBR) that were habituated to new objects and their spatial location, had enhanced episodic memory in the spatial object recognition test, whereas individually-trained animals failed to solve this task. Notably, the co-learning effect was genotype-dependent. BTBR mice paired with BTBR cage-mates in the habituation session modestly ameliorated their performance in the object recognition test but co-learning with a familiar C57BL/6J mouse completely normalized episodic memory deficit. Next, we explored the co-learning effect on fear memory in these inbred strains. Interestingly, mice of both genotypes displayed significantly enhanced contextual fear memory once they had been conditioned together with BTBR animals. The same influence of BTBR presence was observed on cued fear memory in C57BL/6J mice, whereas a modest co-learning effect was found on cued fear conditioning in the BTBR strain. Taken together, we demonstrated for the first time the co-learning effect on cognitive capacities in mice, which can be modified by genetic background and environmental conditions. The possible implications of this methodological approach in social neuroscience are discussed. This article is part of a Special Issue entitled 'Cognitive Enhancers'.

  13. Electric Avenue. A Utility Company's Work Experience Program Broadens Opportunities for Students.

    ERIC Educational Resources Information Center

    Ingles, Pat

    1994-01-01

    A job skills partnership between Southern California Edison Company and local high schools pairs juniors and seniors with journeyworker mentors for a year, experiencing six-week rotations in maintenance, operations, administration, warehouse, and technical occupations. (JOW)

  14. Graph theory and cognition: A complementary avenue for examining neuropsychological status in epilepsy.

    PubMed

    Garcia-Ramos, Camille; Lin, Jack J; Kellermann, Tanja S; Bonilha, Leonardo; Prabhakaran, Vivek; Hermann, Bruce P

    2016-11-01

    The recent revision of the classification of the epilepsies released by the ILAE Commission on Classification and Terminology (2005-2009) has been a major development in the field. Papers in this section of the special issue explore the relevance of other techniques to examine, categorize, and classify cognitive and behavioral comorbidities in epilepsy. In this review, we investigate the applicability of graph theory to understand the impact of epilepsy on cognition compared with controls and, then, the patterns of cognitive development in normally developing children which would set the stage for prospective comparisons of children with epilepsy and controls. The overall goal is to examine the potential utility of this analytic tool and approach to conceptualize the cognitive comorbidities in epilepsy. Given that the major cognitive domains representing cognitive function are interdependent, the associations between neuropsychological abilities underlying these domains can be referred to as a cognitive network. Therefore, the architecture of this cognitive network can be quantified and assessed using graph theory methods, rendering a novel approach to the characterization of cognitive status. We first provide fundamental information about graph theory procedures, followed by application of these techniques to cross-sectional analysis of neuropsychological data in children with epilepsy compared with that of controls, concluding with prospective analysis of neuropsychological development in younger and older healthy controls. This article is part of a Special Issue entitled "The new approach to classification: Rethinking cognition and behavior in epilepsy".

  15. Pendular Proteins in Gases and New Avenues for Characterization of Macromolecules by Ion Mobility Spectrometry

    SciTech Connect

    Shvartsburg, Alexandre A.; Noskov, Sergei; Purves, Randy; Smith, Richard D.

    2009-04-21

    Polar molecules align in electric fields when the dipole energy (proportional to field intensity E × dipole moment p) exceeds the thermal rotational energy. Small molecules have low p and align only at inordinately high E or upon extreme cooling. Many biomacromolecules and ions are strong permanent dipoles and may align at E achievable in gases and room temperature. The collision cross sections of aligned ions with gas molecules generally differ from orientationally averaged quantities, affecting ion mobilities measured in ion mobility spectrometry (IMS). Field asymmetric waveform IMS (FAIMS) separates ions by the difference between mobilities at high and low E and hence can resolve and identify macroion conformers based on the mobility difference between pendular and free rotor states. An exceptional sensitivity of that difference to the ion geometry and charge distribution holds the potential for a powerful new method for separation and characterization of macromolecular species. Theory predicts that the pendular alignment of ions in gases at any E requires a minimum p depending on the ion mobility, gas pressure, and temperature. At ambient conditions used in current FAIMS systems, the p for realistic ions must exceed ~300 - 400 Debye. The dipole moments of proteins statistically increase with increasing mass, and such values are typical above ~30 kDa. FAIMS analyses of protein ions and complexes of ~30 - 130 kDa show an order-of-magnitude expansion of separation space compared to smaller proteins and other ions, consistent with expectations for the dipole-aligned regime.

  16. Grassland-Cropping Rotations: An Avenue for Agricultural Diversification to Reconcile High Production with Environmental Quality

    NASA Astrophysics Data System (ADS)

    Lemaire, Gilles; Gastal, François; Franzluebbers, Alan; Chabbi, Abad

    2015-11-01

    A need to increase agricultural production across the world to ensure continued food security appears to be at odds with the urgency to reduce the negative environmental impacts of intensive agriculture. Around the world, intensification has been associated with massive simplification and uniformity at all levels of organization, i.e., field, farm, landscape, and region. Therefore, we postulate that negative environmental impacts of modern agriculture are due more to production simplification than to inherent characteristics of agricultural productivity. Thus by enhancing diversity within agricultural systems, it should be possible to reconcile high quantity and quality of food production with environmental quality. Intensification of livestock and cropping systems separately within different specialized regions inevitably leads to unacceptable environmental impacts because of the overly uniform land use system in intensive cereal areas and excessive N-P loads in intensive animal areas. The capacity of grassland ecosystems to couple C and N cycles through microbial-soil-plant interactions as a way for mitigating the environmental impacts of intensive arable cropping system was analyzed in different management options: grazing, cutting, and ley duration, in order to minimize trade-offs between production and the environment. We suggest that integrated crop-livestock systems are an appropriate strategy to enhance diversity. Sod-based rotations can temporally and spatially capture the benefits of leys for minimizing environmental impacts, while still maintaining periods and areas of intensive cropping. Long-term experimental results illustrate the potential of such systems to sequester C in soil and to reduce and control N emissions to the atmosphere and hydrosphere.

  17. The unexplored avenues of human skin: electromagnetic properties in the sub-THz band

    NASA Astrophysics Data System (ADS)

    Feldman, Y.; Safrai, E.; Ben Ishai, P.; Puzenko, A.; Agranat, A. J.; Caduff, A.

    2012-03-01

    Recent studies of the minute morphology of the skin by optical coherence tomography showed that the sweat ducts in human skin become helically shaped tubes in the Epidermis and are filled with an aqueous solution. When considered as entities embedded in a dielectric media, they resemble helical antennas. The spectral response obtained by our computer simulations coincides with the analytical prediction of antenna theory and support this hypothesis, if a fast enough current mechanism exists in the duct. In particular the strongest spectral response of the simulation was noted around the predicted frequencies (240 GHz and 380 GHz) for the respective normal and axial modes of the helical structure. Furthermore, circular dichroism of the reflected electromagnetic field is a characteristic property of such helical antennas and it was shown that it is indeed a characteristic of the simulation model. Fast proton hopping is posited as the current mechanism. Consequently experimental evidence is presented that the spectral response of the skin in the sub-Terahertz region is governed by the level of activity of the perspiration system. This in turn is moderated by the Sympathetic Nerve Response and is demonstrated by the correlation to physiological stress as manifested by the pulse rate and the systolic blood pressure. These physical relaxations are tonic in nature (lasting more than a minute). Could the phasic characteristic of emotional excitation also be evident in the reflection coefficient? By applying techniques borrowed from psychiatric science we hope to answer this point in our paper.

  18. A facile avenue to conductive polymer brushes via cyclopentadiene-maleimide Diels-Alder ligation.

    PubMed

    Yameen, Basit; Rodriguez-Emmenegger, Cesar; Preuss, Corinna M; Pop-Georgievski, Ognen; Verveniotis, Elisseos; Trouillet, Vanessa; Rezek, Bohuslav; Barner-Kowollik, Christopher

    2013-10-07

    Cyclopentadienyl end-capped poly(3-hexylthiophene) was employed to fabricate conductive surface tethered polymer brushes via a facile route based on cyclopentadiene-maleimide Diels-Alder ligation. The efficient nature of the Diels-Alder ligation was further combined with a biomimetic polydopamine-assisted functionalization of surfaces, making it an access route of choice for P3HT surface immobilization.

  19. Aggression, Violence and Injury in Minor League Ice Hockey: Avenues for Prevention of Injury

    PubMed Central

    Cusimano, Michael D.; Ilie, Gabriela; Mullen, Sarah J.; Pauley, Christopher R.; Stulberg, Jennifer R.; Topolovec-Vranic, Jane; Zhang, Stanley

    2016-01-01

    Background In North America, more than 800,000 youth are registered in organized ice hockey leagues. Despite the many benefits of involvement, young players are at significant risk for injury. Body-checking and aggressive play are associated with high frequency of game-related injury including concussion. We conducted a qualitative study to understand why youth ice hockey players engage in aggressive, injury-prone behaviours on the ice. Methods Semi-structured interviews were conducted with 61 minor ice hockey participants, including male and female players, parents, coaches, trainers, managers and a game official. Players were aged 13–15 playing on competitive body checking teams or on non-body checking teams. Interviews were manually transcribed, coded and analyzed for themes relating to aggressive play in minor ice hockey. Results Parents, coaches, teammates and the media exert a large influence on player behavior. Aggressive behavior is often reinforced by the player’s social environment and justified by players to demonstrate loyalty to teammates and especially injured teammates by seeking revenge particularly in competitive, body-checking leagues. Among female and male players in non-body checking organizations, aggressive play is not reinforced by the social environment. These findings are discussed within the framework of social identity theory and social learning theory, in order to understand players’ need to seek revenge and how the social environment reinforces aggressive behaviors. Conclusion This study provides a better understanding of the players’ motivations and environmental influences around aggressive and violent play which may be conducive to injury. The findings can be used to help design interventions aimed at reducing aggression and related injuries sustained during ice hockey and sports with similar cultures and rules. PMID:27258426

  20. G protein-coupled receptors as oncogenic signals in glioma: emerging therapeutic avenues.

    PubMed

    Cherry, A E; Stella, N

    2014-10-10

    Gliomas are the most common malignant intracranial tumors. Newly developed targeted therapies for these cancers aim to inhibit oncogenic signals, many of which emanate from receptor tyrosine kinases, including the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptor (VEGFR). Unfortunately, the first-generation treatments targeting these oncogenic signals provide little survival benefit in both mouse xenograft models and human patients. The search for new treatment options has uncovered several G protein-coupled receptor (GPCR) candidates and generated a growing interest in this class of proteins as alternative therapeutic targets for the treatment of various cancers, including glioblastoma multiforme (GBM). GPCRs constitute a large family of membrane receptors that influence oncogenic pathways through canonical and non-canonical signaling. Accordingly, evidence indicates that GPCRs display a unique ability to crosstalk with receptor tyrosine kinases, making them important molecular components controlling tumorigenesis. This review summarizes the current research on GPCR functionality in gliomas and explores the potential of modulating these receptors to treat this devastating disease.

  1. Brownfields Green Avenue Sites: Technical Memorandum - Conceptual Design for Sustainable Redevelopment

    EPA Pesticide Factsheets

    This technical memorandum briefly describes the site and proposed conceptual site plan, indicates conceptual design considerations, specifies recommended green and sustainable features, and offers other recommendations

  2. DOE ZERH Case Study: Heirloom Design Build, Euclid Avenue, Atlanta, GA

    SciTech Connect

    none,

    2015-09-01

    Case study of a DOE 2015 Housing Innovation Award winning custom home in the mixed-humid climate that got a HERS 50 without PV, with 2x6 16” on center walls with R-19 ocsf; basement with R-28 ccsf, R-5 rigid foam under slab; sealed attic with R-28 ocsf under roof deck; 22.8 SEER; 12.5 HSPF heat pump.

  3. Compatibility of Ninth Avenue Superfund Site Ground Water with Two Soil- Bentonite Slurry Wall Backfill Mixtures

    DTIC Science & Technology

    1990-05-01

    1 CONVERSION FACTORS , NON-SI TO SI (METRIC) UNITS OF MEASUREMENT........... 3 PART I: INTRODUCTION...C1 APPENDIX D: PERMEABILITY DATA FOR CELLS 1 THROUGH 16 .................... D1 2 CONVERSION FACTORS , NON-SI TO SI (METRIC) UNITS OF...potassium. A variety of * A table of factors for converting non-SI units of measurement to SI (metric) units is presented on page 3. 4 39 .’ " ’ I" . 600

  4. Metabolic disruption in context: Clinical avenues for synergistic perturbations in energy homeostasis by endocrine disrupting chemicals

    PubMed Central

    Sargis, Robert M

    2015-01-01

    The global epidemic of metabolic disease is a clear and present danger to both individual and societal health. Understanding the myriad factors contributing to obesity and diabetes is essential for curbing their decades-long expansion. Emerging data implicate environmental endocrine disrupting chemicals (EDCs) in the pathogenesis of metabolic diseases such as obesity and diabetes. The phenylsulfamide fungicide and anti-fouling agent tolylfluanid (TF) was recently added to the list of EDCs promoting metabolic dysfunction. Dietary exposure to this novel metabolic disruptor promoted weight gain, increased adiposity, and glucose intolerance as well as systemic and cellular insulin resistance. Interestingly, the increase in body weight and adipose mass was not a consequence of increased food consumption; rather, it may have resulted from disruptions in diurnal patterns of energy intake, raising the possibility that EDCs may promote metabolic dysfunction through alterations in circadian rhythms. While these studies provide further evidence that EDCs may promote the development of obesity and diabetes, many questions remain regarding the clinical factors that modulate patient-specific consequences of EDC exposure, including the impact of genetics, diet, lifestyle, underlying disease, pharmacological treatments, and clinical states of fat redistribution. Currently, little is known regarding the impact of these factors on an individual’s susceptibility to environmentally-mediated metabolic disruption. Advances in these areas will be critical for translating EDC science into the clinic to enable physicians to stratify an individual’s risk of developing EDC-induced metabolic disease and to provide direction for treating exposed patients. PMID:27011951

  5. Enlisting Madison Avenue: The Marketing Approach to Earning Popular Support in Theaters of Operation

    DTIC Science & Technology

    2007-01-01

    and behaviors. Businesses save valu- able resources by not wasting efforts on consumers unlikely to make a purchase.5 Sometimes, businesses market a... businesses must synchronize and align every brand- consumer touchpoint to convey a single, clear, and uniform message. To accomplish this, companies...Company knew an opportunity existed when it oriented its business around picking up consumers at their homes or offices, and Starwood Hotels and

  6. International Education for High-Ability Students: An Avenue to Excellence.

    ERIC Educational Resources Information Center

    Daniel, Neil; Cox, June

    1992-01-01

    Both the United World Colleges and the International Baccalaureate offer exciting educational alternatives for high-ability students. Based on international understanding through educational exchange, the World Colleges are composed of students and faculties from many nations and all races. A Houston Theory of Knowledge project to prepare students…

  7. Re-experiencing traumatic events in PTSD: new avenues in research on intrusive memories and flashbacks

    PubMed Central

    Brewin, Chris R.

    2015-01-01

    Posttraumatic flashbacks, consisting of the intrusive re-experiencing of traumatic experiences in the present, have been more clearly defined for the first time in DSM-5 and have been identified as a unique symptom of posttraumatic stress disorder in the proposed ICD-11 diagnostic criteria. Relatively little research into flashbacks has been conducted, however, and new research efforts are required to understand the cognitive and biological basis of this important symptom. In addition, there is considerable scope for research into how flashbacks should be assessed and into flashbacks occurring in different contexts, such as psychosis or intensive care. PMID:25994019

  8. Liquid-crystal nanoscience: an emerging avenue of soft self-assembly.

    PubMed

    Bisoyi, Hari Krishna; Kumar, Sandeep

    2011-01-01

    Liquid crystals are finding increasing applications in a wide variety of fields including liquid-crystal display technology, materials science, bioscience, etc., apart from acting as prototype self-organizable supramolecular soft materials and tunable solvents. Recently, keeping in pace with topical science, liquid crystals have entered into the fascinating domains of nanoscience and nanotechnology. This tutorial review describes the recent and significant developments in liquid-crystal nanoscience embracing contemporary nanomaterials such as nanoparticles, nanorods, nanotubes, nanoplatelets, etc. The dispersion of zero-, one- and two-dimensional nanomaterials in liquid crystals for the enhancement of properties, liquid-crystalline phase behavior of nanomaterials themselves, self-assembly and alignment of nanomaterials in liquid-crystalline media, and the synthesis of nanomaterials by using liquid crystals as 'templates' or 'precursors' have been highlighted and discussed. It is almost certain that the 'fourth state of matter' will play more prevalent roles in nanoscience and nanotechnology in the near future. Moreover, liquid-crystal nanoscience reflects itself as a beautiful demonstration of the contemporary theme "crossing the borders: science without boundaries".

  9. The Importance of Acidification in Atopic Eczema: An Underexplored Avenue for Treatment.

    PubMed

    Panther, David J; Jacob, Sharon E

    2015-05-18

    Atopic dermatitis is a form of dermatitis commonly seen in children and adults. Its pathophysiology is complex and is centered on the barrier function of the epidermis. An important aspect of the skin's barrier is pH, which in turn affects a number of parameters such as the skin flora, protease function, and mediators of inflammation and pruritus. Normal pH for non-neonatal skin is acidic and ranges from 4 to 6. Skin pH in atopic dermatitis patients is often increased into the neutral to basic range, and the resulting cascade of changes contributes to the phenotype of atopic dermatitis. Therefore, the maintenance of normal skin pH remains an important topic in understanding and treating atopic dermatitis. This article will review skin pH and its impact on normal barrier function, pathological pH changes in atopic dermatitis, and the therapeutic considerations related to restoring and maintaining pH balance.

  10. Molecular epidemiology in cancer risk assessment and prevention: recent progress and avenues for future research.

    PubMed Central

    Wogan, G N

    1992-01-01

    Molecular epidemiology is increasingly being applied in studies of cancer risks derived from exposure to environmental carcinogens of both endogenous and exogenous origins. Analytical methods have been developed that are capable of detecting and quantifying levels of covalent adducts of several important classes of carcinogens with cellular DNA and blood proteins. Methods of sufficient sensitivity and specificity to detect ambient levels of exposure are in current use. These are being used in studies related to tobacco use (polycyclic aromatic hydrocarbons, aromatic amines, tobacco-specific nitrosamines); dietary exposures (aflatoxins, N-nitrosamines, heterocyclic amines); medicinal exposures (cisplatin, alkylating agents, 8-methoxypsoralen, ultraviolet photoproducts); occupational exposures (aromatic amines, polycyclic aromatic hydrocarbons, oxides of ethylene and styrene, and vinyl chloride); and oxidative damage (8-hydroxyguanine, thymine glycol). Methodologic improvements together with their expanded use in feasibility studies continue to produce results that support the validity of this approach for detecting and quantifying exposure to carcinogens. Genetic markers are also being used to detect early biological responses in efforts to link carcinogen exposure to initiating events in the carcinogenesis process. These include, in addition to traditional cytogenetic markers (e.g., chromosomal aberrations, sister chromatid exchange, micronuclei), other alterations in chromosomal structure such as restriction fragment length polymorphisms, loss of heterozygosity, and translocation markers. Specific genetic changes have recently been identified as critical molecular events in the initiation and development of many cancers. Important among these are activation of oncogenes, especially those of the ras family, and inactivation of tumor-suppressor genes (e.g., p53 and Rb) by point mutations and/or chromosomal deletions and other structural changes. Although some of these changes are known to occur in chemically induced tumors of experimental animals, the possible role of chemical carcinogens in the induction of genetic abnormalities in human cancers has yet to be determined. Continuing investigations employing the methods of molecular epidemiology promise to provide further evidence concerning these relationships. Future investigations employing newly developed molecular biological methods, in particular those based on polymerase chain reaction amplification of DNA, to identify alterations in DNA and chromosomal structure, combined with methods for characterizing exposure to carcinogens and early effects, have great potential for further elucidating the role of genotoxic agents in the etiology of human cancers and also for the development of strategies for their prevention. PMID:1486846

  11. Powder-Coated Towpreg: Avenues to Near Net Shape Fabrication of High Performance Composites

    NASA Technical Reports Server (NTRS)

    Johnston, N. J.; Cano, R. J.; Marchello, J. M.; Sandusky, D. A.

    1995-01-01

    Near net shape parts were fabricated from powder-coated preforms. Key issues including powder loss during weaving and tow/tow friction during braiding were addressed, respectively, by fusing the powder to the fiber prior to weaving and applying a water-based gel to the towpreg prior to braiding. A 4:1 debulking of a complex 3-D woven powder-coated preform was achieved in a single step utilizing expansion rubber molding. Also, a process was developed for using powder-coated towpreg to fabricate consolidated ribbon having good dimensional integrity and low voids. Such ribbon will be required for in situ fabrication of structural components via heated head advanced tow placement. To implement process control and ensure high quality ribbon, the ribbonizer heat transfer and pulling force were modeled from fundamental principles. Most of the new ribbons were fabricated from dry polyarylene ether and polymide powders.

  12. Ischemic postconditioning as a novel avenue to protect against brain injury after stroke

    PubMed Central

    Zhao, Heng

    2009-01-01

    Ischemic postconditioning initially referred to a stuttering reperfusion performed immediately after reperfusion, for preventing ischemia/reperfusion injury in both myocardial and cerebral infarction. It has evolved into a concept that can be induced by a broad range of stimuli or triggers, and may even be performed as late as 6 h after focal ischemia and 2 days after transient global ischemia. The concept is thought to be derived from ischemic preconditioning or partial/gradual reperfusion, but in fact the first experiment for postconditioning was carried out much earlier than that of preconditioning or partial/gradual reperfusion, in the research on myocardial ischemia. This review first examines the protective effects and parameters of postconditioning in various cerebral ischemic models. Thereafter, it provides insights into the protective mechanisms of postconditioning associated with reperfusion injury and the Akt, mitogen-activated protein kinase (MAPK), protein kinase C (PKC), and ATP-sensitive K+ (KATP) channel cell signaling pathways. Finally, some open issues and future challenges regarding clinical translation of postconditioning are discussed. PMID:19240739

  13. Japan Fulbright Memorial Fund Program Opens New Avenues for Effective Technology Integration into Education

    NASA Astrophysics Data System (ADS)

    Paoletti, Franco; Carlucci, Lisa Marie

    2006-04-01

    Technology is increasingly playing a major role in today's education often integrated into instruction to become one of the teacher's most effective and often indispensable tools used in the classroom. It can be said that the use of technology at the beginning of this new millennium is affecting the instructional process and it is changing some of its basic connotations. The presented work analyzes the impact of various technologies on education emphasizing the advantages provided by a successful integration, the obstacles encountered along the way, and the methodologies currently used in the process. ``Educational exchange can turn nations into people, contributing as no other form of communication can to the humanizing of international relations'' (Senator J.M. Fulbright). Technology of this modern era is providing the indispensable tool to achieve this superior level of communication overcoming historical, cultural, and language barriers. In the context of the Japan Fulbright Memorial Fund (JFMF) Teacher Program, we analyze the impact of technology on educational cross-cultural exchanges to raise awareness and interest of the scientific/educational community on the need of establishing stronger international relations promoting world peace and global prosperity.

  14. Integrating movement ecology with biodiversity research - exploring new avenues to address spatiotemporal biodiversity dynamics.

    PubMed

    Jeltsch, Florian; Bonte, Dries; Pe'er, Guy; Reineking, Björn; Leimgruber, Peter; Balkenhol, Niko; Schröder, Boris; Buchmann, Carsten M; Mueller, Thomas; Blaum, Niels; Zurell, Damaris; Böhning-Gaese, Katrin; Wiegand, Thorsten; Eccard, Jana A; Hofer, Heribert; Reeg, Jette; Eggers, Ute; Bauer, Silke

    2013-01-01

    Movement of organisms is one of the key mechanisms shaping biodiversity, e.g. the distribution of genes, individuals and species in space and time. Recent technological and conceptual advances have improved our ability to assess the causes and consequences of individual movement, and led to the emergence of the new field of 'movement ecology'. Here, we outline how movement ecology can contribute to the broad field of biodiversity research, i.e. the study of processes and patterns of life among and across different scales, from genes to ecosystems, and we propose a conceptual framework linking these hitherto largely separated fields of research. Our framework builds on the concept of movement ecology for individuals, and demonstrates its importance for linking individual organismal movement with biodiversity. First, organismal movements can provide 'mobile links' between habitats or ecosystems, thereby connecting resources, genes, and processes among otherwise separate locations. Understanding these mobile links and their impact on biodiversity will be facilitated by movement ecology, because mobile links can be created by different modes of movement (i.e., foraging, dispersal, migration) that relate to different spatiotemporal scales and have differential effects on biodiversity. Second, organismal movements can also mediate coexistence in communities, through 'equalizing' and 'stabilizing' mechanisms. This novel integrated framework provides a conceptual starting point for a better understanding of biodiversity dynamics in light of individual movement and space-use behavior across spatiotemporal scales. By illustrating this framework with examples, we argue that the integration of movement ecology and biodiversity research will also enhance our ability to conserve diversity at the genetic, species, and ecosystem levels.

  15. The menopause transition in women living with HIV: current evidence and future avenues of research.

    PubMed

    Tariq, Shema; Anderson, Jane; Burns, Fiona; Delpech, Valerie; Gilson, Richard; Sabin, Caroline

    2016-04-01

    As the life expectancy of people living with HIV improves as a result of antiretroviral therapy, increasing numbers of women living with HIV (WLHIV) are now reaching menopausal age. The menopause transition in WLHIV remains a relatively overlooked area in clinical HIV research. Whilst there is some evidence to suggest that WLHIV experience menopause at an earlier age and that they have more menopausal symptoms, there is no clear consensus in the literature around an impact of HIV infection on either timing or symptomatology of the menopause. Data are also conflicting on whether HIV-related factors such as HIV viral load and CD4 cell count have an impact on the menopause. Furthermore, menopausal symptoms in WLHIV are known to go under-recognised by both healthcare providers and women themselves. There is likely to be a burden of unmet health needs among WLHIV transitioning through the menopause, with significant gaps in the evidence base for their care. With this in mind, we have developed the PRIME study (Positive Transitions Through the Menopause). This mixed-methods observational study will explore, for the first time in the UK, the impact of the menopause on the health and wellbeing of 1500 ethnically diverse WLHIV. In establishing a cohort of women in their midlife and following them up longitudinally, we hope to develop a nuanced understanding of the gendered aspects of ageing and HIV, informing the provision of appropriate services for WLHIV to ensure that they are supported in maintaining optimal health and wellbeing as they get older.

  16. Teamwork in skull base surgery: An avenue for improvement in patient care

    PubMed Central

    McLaughlin, Nancy; Carrau, Ricardo L.; Kelly, Daniel F.; Prevedello, Daniel M.; Kassam, Amin B.

    2013-01-01

    Background: During the past several decades, numerous centers have acquired significant expertise in the treatment of skull base pathologies. Favorable outcomes are not only due to meticulous surgical planning and execution, but they are also related to the collaborative efforts of multiple disciplines. We review the impact of teamwork on patient care, elaborate on the key processes for successful teamwork, and discuss its challenges. Methods: Pubmed and Medline databases were searched for publications from 1970 to 2012 using the following keywords: “teamwork”, “multidisciplinary”, “interdisciplinary”, “surgery”, “skull base”, “neurosurgery”, “tumor”, and “outcome”. Results: Current literature testifies to the complexity of establishing and maintaining teamwork. To date, few reports on the impact of teamwork in the management of skull base pathologies have been published. This lack of literature is somewhat surprising given that most patients with skull base pathology receive care from multiple specialists. Common factors for success include a cohesive and well-integrated team structure with well-defined procedural organization. Although a multidisciplinary work force has clear advantages for improving today's quality of care and propelling research efforts for tomorrow's cure, teamwork is not intuitive and requires training, guidance, and executive support. Conclusions: Teamwork is recommended to improve quality over the full cycle of care and consequently patient outcomes. Increased recognition of the value of an integrated team approach for skull base pathologies will hopefully encourage centers, physicians, allied health caregivers, and scientists devoted to treating these patients and advancing the field of knowledge to invest the time, effort, and resources to optimize and organize their collective expertise. PMID:23607058

  17. Peer Contexts in Schools: Avenues Toward Behavioral Health in Early Adolescence.

    PubMed

    Cappella, Elise; Hwang, Sophia H J

    2015-01-01

    Peer contexts play an important role in the behavioral health of early adolescents in schools. Behavioral health involves the observable academic and social behaviors that relate to and influence youths' subsequent health and development. Setting-level research on peer networks and social norms indicates these aspects of peer contexts vary by peer group, classroom, and school and dynamically relate to individual students' academic and social behaviors. Yet, although peer contexts are both influential and potentially malleable, little research examines the effects of school and classroom interventions on the development and maintenance of positive and productive peer contexts in schools. The current article identifies school structures and classroom processes theorized to directly or indirectly shift peer networks and social norms-and thereby increase the behavioral health of early adolescents in schools. We discuss the need for more rigorous and relevant research to better understand the role of schools and classrooms in strengthening these peer contexts and promoting behavioral health in early adolescence.

  18. Telomeres and Stress: Promising Avenues for Research in Psycho-Oncology

    PubMed Central

    Law, Eleanor; Girgis, Afaf; Sylvie, Lambert; Levesque, Janelle; Pickett, Hilda

    2016-01-01

    A cancer diagnosis and subsequent treatment is a stressful experience with the potential for long-term health consequences for both patients and their caregivers. It is now well-established that psychological stress is associated with detrimental effects on physical health. Recent studies have investigated the link between telomeres, the protective cap at the end of chromosomes, and stress, suggesting that stress potentially impacts on cellular aging through telomere shortening, with subsequent consequences for health. This review aims to familiarize the reader with the pertinent literature exploring the relationship between telomeres and psychological and behavioral factors and propose future directions for telomere research in psycho-oncology. PMID:27981152

  19. Delivery of drugs bound to erythrocytes: new avenues for an old intravascular carrier

    PubMed Central

    Villa, Carlos H; Pan, Daniel C; Zaitsev, Sergei; Cines, Douglas B; Siegel, Donald L; Muzykantov, Vladimir R

    2015-01-01

    For several decades, researchers have used erythrocytes for drug delivery of a wide variety of therapeutics in order to improve their pharmacokinetics, biodistribution, controlled release and pharmacodynamics. Approaches include encapsulation of drugs within erythrocytes, as well as coupling of drugs onto the red cell surface. This review focuses on the latter approach, and examines the delivery of red blood cell (RBC)-surface-bound anti-inflammatory, anti-thrombotic and anti-microbial agents, as well as RBC carriage of nanoparticles. Herein, we discuss the progress that has been made in surface loading approaches, and address in depth the issues relevant to surface loading of RBC, including intrinsic features of erythrocyte membranes, immune considerations, potential surface targets and techniques for the production of affinity ligands. PMID:26228773

  20. Confirmatory/release survey of the property at 71 Pearce Avenue (Former EAD Building) in Tonawanda, New York

    SciTech Connect

    Salame-Alfie, A.; Alibozek, R.

    1995-12-31

    EAD Metallurgical, Inc., operated a facility in Tonawanda, New York, in which it utilized Americium 241 (Am-241) for the production of foil sources for use in smoke detectors. EAD was in operation between 1977 and 1983. By 1983, the company started losing money, and decided to relocate to Mexico. Before closing down its Tonawanda operation, however, it was required by the New York State Department of Labor (DOL) to decontaminate its facility to limits specified by DOL. No records of discharges to the sewer system were kept during this decontamination effort. Unsuccessful decontamination efforts by several EAD employees and contractors left the building contaminated, in particular the concrete floors and walls. To determine the scope of work for the decontamination project, staff from the New York State Departments of Health (DOH) and Environmental Conservation (DEC) conducted a Characterization Survey of the facility in 1993. This survey identified contamination levels of Am-241 in excess of release limits throughout the building, in the soil outside the facility, in pipes for sewage and interior drainage, and in an 8 x 8 x 11 foot sump pit in the building. DOH issued a request for proposals in early 1994 for the decontamination and subsequent decommissioning of the former EAD building, and NES/IES Inc. (NES) was awarded the contract to perform the remediation. DOH`s assignment was to provide an on-site presence to insure the completion of all agreed upon tasks, according to the terms of the contract and work plans submitted by NES. Additionally, the DOH staff acted as a liaison between NES, DOH, DEC and DOL central offices to review, comment and approve all changes or modifications to NES`s approach to the decontamination efforts. The assigned staff was also responsible for conducting confirmatory sampling and surveys of all areas deemed releasable to DOL and DEC criteria by NES.

  1. Evolutionary avenues for, and constraints on, the transmission of frog lung flukes (Haematoloechus spp.) in dragonfly second intermediate hosts.

    PubMed

    Bolek, Matthew G; Janovy, John

    2007-06-01

    Metacercariae survival patterns and their distribution in second intermediate odonate hosts were examined for 4 species of frog lung flukes. Surveys of aquatic larvae and recently emerged teneral dragonflies and damselflies indicated that prevalence and mean abundance of Haematoloechus spp. metacercariae were significantly lower in teneral dragonflies than larval dragonflies, while there was no significant difference in prevalence or mean abundance of Haematoloechus spp. metacercariae among larval and teneral damselflies. Experimental infections of dragonflies indicated that metacercariae of Haematoloechus coloradensis and Haematoloechus complexus were located in the head, thorax, and branchial basket of dragonflies, whereas metacercariae of Haematoloechus longiplexus and Haematoloechus parviplexus were restricted to the branchial basket of these hosts. Metacercariae of H. coloradensis, H. complexus, and H. longiplexus infected the head, thorax, and abdomen of damselflies, but these insects were resistant to infection with H. parviplexus. Subsequent metamorphosis experiments on experimentally infected dragonflies indicated that most metacercariae of H. longiplexus were lost from the branchial basket during metamorphosis, but most metacercariae of H. coloradensis, H. complexus, and H. parviplexus survived dragonfly metamorphosis. These observations suggest that the observed ecological host specificity of H. longiplexus in semiterrestrial leopard frogs may be due to few metacercariae of H. longiplexus reaching these frogs in a terrestrial environment. Because of the uncertain validity of Haematoloechus varioplexus as a distinct species from its synonym H. parviplexus, their morphological characters were reevaluated. The morphological data on H. varioplexus and H. parviplexus indicate that they differ in their acetabulum length and width, ovary shape, testes length, and egg length and width. Experimental infections of plains leopard frogs, northern leopard frogs, and bullfrogs with worms from bullfrogs indicate that the synonymy of H. parviplexus with H. varioplexus is not warranted, and that these flukes are distinct species, i.e., H. parviplexus in bullfrogs and H. varioplexus in plains leopard frogs and northern leopard frogs.

  2. Integrating Ecological Momentary Assessment and Functional Brain Imaging Methods: New Avenues for Studying and Treating Tobacco Dependence

    PubMed Central

    2014-01-01

    Introduction: Ecological momentary assessment (EMA) and related methods typically entail repeatedly and intensively sampling behavior as it occurs over time and under naturalistic conditions. Although the methodological features of EMA make it a highly valuable research technique in its own right, EMA can also be a potent counterpart to other approaches. One methodological partnership with substantial yet largely untapped potential for the study of tobacco dependence is the pairing of EMA with functional brain imaging. Methods: The goal of this review is to outline the promise of this approach, with a focus on the combined use of EMA and functional magnetic resonance imaging (fMRI). Due to the unique and complementary strengths of each method, the merger of EMA and fMRI methods has the potential to advance the understanding of tobacco dependence in ways difficult or impossible to achieve through the use of either method in isolation. Results: In addition to describing a conceptual basis for combining EMA with fMRI, we provide a preliminary empirical illustration of this integrative approach using data from an ongoing study. Conclusions: EMA and fMRI have independently yielded important findings regarding the nature and treatment of tobacco dependence. The integration of these powerful research methods, however, holds even greater potential for the field of tobacco research. Additionally, recent advances are paving the way for the synergistic use of fMRI and EMA-based methods to develop innovative approaches to tobacco cessation. PMID:24132411

  3. Environmental Assessment for the Improvements and Repair to Forty-Niner Avenue Holloman Air Force Base, New Mexico

    DTIC Science & Technology

    2005-06-01

    proposed action area. 1be roadway will continue to degrade and eventually fail. (2) The current roadway consists of two lanes and is only 24 feet ...continue to degrade and eventually fail. • The current roadway consists of two lanes and is only 24 feet wide. This makes it difficult to pass slow...eventually fail. • The current roadway consists of two lanes and is only 24 feet wide. This makes it difficult to pass slow moving vehicles, such as

  4. Radiological assessment report for the University of Rochester Annex, 400 Elmwood Avenue, Rochester, New York, April-May 1984

    SciTech Connect

    Wynveen, R.A.; Smith, W.H.; Sholeen, C.M.; Flynn, K.F.

    1984-12-01

    In light of the results of the comprehensive radiological assessment of the annex and auxiliary facilities, the following conclusions can be made: There is no immediate hazard from the elevated levels of radioactivity detected; however, some of these levels are above criteria. The radon, thoron, actinon, long-lived particulates, and tritium in the air are all below criteria for unrestricted use. Some ductwork has been identified as being contaminated. All ductwork must, therefore, be considered potentially contaminated. Since several floor drains were found to exhibit elevated readings, and the samples had elevated concentrations of radionuclides, it must be concluded that the drain and sewer systems of the Annex are contaminated with radioactive material. Since the samples collected from the storm and sewer systems outside the building also had elevated concentrations of radionuclides, these systems are also considered contaminated with radioactive material. The grounds around the Annex have exhibited background concentrations of radionuclides. Two rooms, B-330 and B-332, were inaccessible for survey due to the presence of stored furniture and equipment. Therefore, no comment about their radiological status can be made. At the common baseboard for Room C-12 and C-16 and on the floor below the tile in Room C-40, contamination appeared to be masked by construction modifications. Other areas of the Annex must also be considered potentially contaminated where modifications may have masked the contamination.

  5. Hyperspectral-stimulated Raman scattering imaging of cholesteryl ester accumulation: new avenue to diagnosis of human prostate cancer

    NASA Astrophysics Data System (ADS)

    Du, Jun; Wang, Ping; Yue, Shuhua

    2016-10-01

    Most prostate cancers (PCa) are slowly growing, and only the aggressive ones require early diagnosis and effective treatment. The current standard for PCa diagnosis remains histopathology. Nonetheless, for the differentiation between Gleason score 6 (low-risk PCa), which can be left without treatment, and Gleason score 7 (high-risk PCa), which requires active treatment, the inter-observer discordance can be up to 40%. Our previous study reveals that cholesteryl ester (CE) accumulation induced by PI3K/AKT activation underlies human PCa aggressiveness. However, Raman spectromicroscopy used in this study could only provide compositional information of certain lipid droplets (LDs) selected by the observer, which overlooked cell-to-cell variation and hindered translation to accurate automated diagnosis. Here, we demonstrated quantitative mapping of CE level in human prostate tissues using hyperspectral stimulated Raman scattering (SRS) microscopy that renders compositional information for every pixel in the image. Specifically, hundreds of SRS images at Raman shift between 1620-1800 cm-1 were taken, and multivariate curve resolution algorism was used to retrieve concentration images of acyl C=C bond, sterol C=C bond, and ester C=O bond. Given that the ratio between images of sterol C=C and ester C=O (sterol C=C/C=O) is nonlinearly proportional to CE percentage out of total lipid, we were able to quantitatively map CE level. Our data showed that CE level was significantly greater in high Gleason grade compared to low Gleason grade, and could be a factor that significantly contributed to cancer recurrence. Our study provides an opportunity towards more accurate PCa diagnosis and prediction of aggressiveness.

  6. Changing Course: Thurgood Marshall College Fund President Johnny Taylor Seeks New Partnerships and Avenues of Support for Public HBCUs

    ERIC Educational Resources Information Center

    Stuart, Reginald

    2011-01-01

    When veteran educator Dr. N. Joyce Payne handed the reins of the organization she founded, the Thurgood Marshall College Fund, to entertainment lawyer and board member Johnny Taylor, Taylor began pursuing a remake of the prestigious group that has turned it on its head in just a matter of months. Today, with just more than a year of leading the…

  7. Drell-Yan process as an avenue to test a noncommutative standard model at the Large Hadron Collider

    NASA Astrophysics Data System (ADS)

    J, Selvaganapathy; Das, Prasanta Kumar; Konar, Partha

    2016-06-01

    We study the Drell-Yan process at the Large Hadron Collider in the presence of the noncommutative extension of the standard model. Using the Seiberg-Witten map, we calculate the production cross section to first order in the noncommutative parameter Θμ ν . Although this idea has been evolving for a long time, only a limited amount of phenomenological analysis has been completed, and this was mostly in the context of the linear collider. An outstanding feature from this nonminimal noncommutative standard model not only modifies the couplings over the SM production channel but also allows additional nonstandard vertices which can play a significant role. Hence, in the Drell-Yan process, as studied in the present analysis, one also needs to account for the gluon fusion process at the tree level. Some of the characteristic signatures, such as oscillatory azimuthal distributions, are an outcome of the momentum-dependent effective couplings. We explore the noncommutative scale ΛNC≥0.4 TeV , considering different machine energy ranging from 7 to 13 TeV.

  8. (13)CHD2-CEST NMR spectroscopy provides an avenue for studies of conformational exchange in high molecular weight proteins.

    PubMed

    Rennella, Enrico; Huang, Rui; Velyvis, Algirdas; Kay, Lewis E

    2015-10-01

    An NMR experiment for quantifying slow (millisecond) time-scale exchange processes involving the interconversion between visible ground state and invisible, conformationally excited state conformers is presented. The approach exploits chemical exchange saturation transfer (CEST) and makes use of (13)CHD2 methyl group probes that can be readily incorporated into otherwise highly deuterated proteins. The methodology is validated with an application to a G48A Fyn SH3 domain that exchanges between a folded conformation and a sparsely populated and transiently formed unfolded ensemble. Experiments on a number of different protein systems, including a 360 kDa half-proteasome, establish that the sensitivity of this (13)CHD2 (13)C-CEST technique can be upwards of a factor of 5 times higher than for a previously published (13)CH3 (13)C-CEST approach (Bouvignies and Kay in J Biomol NMR 53:303-310, 2012), suggesting that the methodology will be powerful for studies of conformational exchange in high molecular weight proteins.

  9. Social Media as Avenue for Personal Learning for Educators: Personal Learning Networks Encourage Application of Knowledge and Skills

    ERIC Educational Resources Information Center

    Eller, Linda S.

    2012-01-01

    Social media sites furnish an online space for a community of practice to create relationships and trust, collaboration and connections, and a personal learning environment. Social networking sites, both public and private, have common elements: member profiles, groups, discussions, and forums. A community of practice brings participants together…

  10. Red blood cells open promising avenues for longitudinal studies of ageing in laboratory, non-model and wild animals.

    PubMed

    Stier, Antoine; Reichert, Sophie; Criscuolo, Francois; Bize, Pierre

    2015-11-01

    Ageing is characterized by a progressive deterioration of multiple physiological and molecular pathways, which impair organismal performance and increase risks of death with advancing age. Hence, ageing studies must identify physiological and molecular pathways that show signs of age-related deterioration, and test their association with the risk of death and longevity. This approach necessitates longitudinal sampling of the same individuals, and therefore requires a minimally invasive sampling technique that provides access to the larger spectrum of physiological and molecular pathways that are putatively associated with ageing. The present paper underlines the interest in using red blood cells (RBCs) as a promising target for longitudinal studies of ageing in vertebrates. RBCs provide valuable information on the following six pathways: cell maintenance and turnover (RBC number, size, and heterogeneity), glucose homeostasis (RBC glycated haemoglobin), oxidative stress parameters, membrane composition and integrity, mitochondrial functioning, and telomere dynamics. The last two pathways are specific to RBCs of non-mammalian species, which possess a nucleus and functional mitochondria. We present the current knowledge about RBCs and age-dependent changes in these pathways in non-model and wild species that are especially suitable to address questions related to ageing using longitudinal studies. We discuss how the different pathways relate with survival and lifespan and give information on their genetic and environmental determinants to appraise their evolutionary potential.

  11. A random walk down university avenue: life paths, life events, and personality trait change at the transition to university life.

    PubMed

    Lüdtke, Oliver; Roberts, Brent W; Trautwein, Ulrich; Nagy, Gabriel

    2011-09-01

    This longitudinal study examined the relation between continuity and change in the Big Five personality traits and life events. Approximately 2,000 German students were tracked from high school to university or to vocational training or work, with 3 assessments over 4 years. Life events were reported retrospectively at the 2nd and 3rd assessment. Latent curve analyses were used to assess change in personality traits, revealing 3 main findings. First, mean-level changes in the Big Five factors over the 4 years were in line with the maturity principle, indicating increasing psychological maturity from adolescence to young adulthood. Second, personality development was characterized by substantive individual differences relating to the life path followed; participants on a more vocationally oriented path showed higher increases in conscientiousness and lower increases in agreeableness than their peers at university. Third, initial level and change in the Big Five factors (especially Neuroticism and Extraversion) were linked to the occurrence of aggregated as well as single positive and negative life events. The analyses suggest that individual differences in personality development are associated with life transitions and individual life experiences.

  12. Stakeholders’ perception on the organization of chronic care: a SWOT analysis to draft avenues for health care reforms

    PubMed Central

    2014-01-01

    Background Adequate care for individuals living with chronic illnesses calls for a healthcare system redesign, moving from acute, disease-centered to patient-centered models. The aim of this study was to identify Belgian stakeholders’ perceptions on the strengths, weaknesses, opportunities and threats of the healthcare system for people with chronic diseases in Belgium. Methods Four focus groups were held with stakeholders from the micro and meso level, in addition to two interviews with stakeholders who could not attend the focus group sessions. Data collection and the discussion were based on the Chronic Care model. Thematic analysis of the transcripts allowed for the identification of the strengths, weaknesses, opportunities and threats of the current health care system with focus on chronic care. Results Informants stressed the overall good quality of the acute health care system and the level of reimbursement of care as an important strength of the current system. In contrast, the lack of integration of care was identified as one of the biggest weaknesses of today’s health care system, along with the unclear definitions of the roles and functions of health professionals involved in care processes. Patient education to support self-management exists for patients with diabetes and/or terminal kidney failure but not for those living with other or multiple chronic conditions. The current overall fee-for-service system is a barrier to integrated care, as are the lack of incentives for integrated care. Attending multidisciplinary meetings, for example, is underfinanced to date. Finally, clinical information systems lack interoperability, which further impedes the information flow across settings and disciplines. Conclusion Our study’s methods allowed for the identification of problematic domains in the health system for people living with chronic conditions. These findings provided useful insights surrounding perceived priorities. This methodology may inspire other countries faced with the challenge of drafting reforms to tackle the issue of chronic care. PMID:24742204

  13. ASSESSING UST CORRECTIVE ACTION TECHNOLOGIES: LESSONS LEARNED ABOUT IN SITU AIR SPARGING AT THE DENISON AVENUE SITE - CLEVELAND, OH

    EPA Science Inventory

    In situ air sparging (IAS) has been proposed and installed at an increasing number of sites to address contamination in both the saturated and unsaturated zones. Because of the lack of experimental and substantive performance data, however, the actual performance and effectivene...

  14. Mammalian Pseudokinase TRIB3 in Normal Physiology and Disease: Charting the Progress in Old and New Avenues.

    PubMed

    Örd, Tiit; Örd, Tõnis

    2017-04-06

    Tribbles homolog 3 (TRIB3) is a mammalian gene that is upregulated in response to several types of cell death-inducing cellular stress. The TRIB3 protein is a pseudokinase, a protein kinase-like scaffold with impaired catalytic activity. However, research has revealed it to be prolific at forming protein-protein interactions. By binding to and regulating the activity of several key proteins, including the protein kinase Akt and transcription factors ATF4, CHOP and NF-κB, TRIB3 is at a junction of several signaling pathways. This review begins by providing insights into the characteristic protein structure and gene expression regulation mechanisms of TRIB3. Further, the diverse reported molecular roles of TRIB3 as a regulator of cell death, stress responses, inflammation, cell differentiation, protein degradation and other processes are discussed. Special attention is devoted to the involvement of TRIB3 in the pathogenesis of cancer and type 2 diabetes, two fields where TRIB3 has generated particular interest, as well as considerable debate, from a biomedical standpoint. Throughout, emphasis is placed on results obtained from animal models with altered TRIB3 expression (Trib3 knockout or overexpression mice), in order to provide insight into the contributions of TRIB3 to physiology and disease at the organism level.

  15. A New Avenue to Cure Cancer by Turning Adaptive Immune T Cells to Innate Immune NK Cells via Reprogramming

    PubMed Central

    Su, Dong-Ming; Vankayalapati, Ramakrishna

    2010-01-01

    Thymocytes after T-lineage commitment develop in the T-cell pathway. However, in a recent study, Li et al. (2010) demonstrated that inducing to delete Bcl11b gene in these thymocytes, even in mature T cells turns these cells into natural killer (NK) cells during the culture. They called this conversion ‘reprogramming’, and the reprogrammed killer cells ‘ITNK cells’. The ITNK cells possessed tumor-killer ability and did not indiscriminately kill normal cells. This exciting finding represents a major breakthrough towards curing cancer and identifies an important, novel transcription factor in the thymus development. PMID:20693167

  16. Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons.

    PubMed

    Sampedro-Piquero, P; Castilla-Ortega, E; Zancada-Menendez, C; Santín, L J; Begega, A

    2016-08-25

    The use of more ethological animal models to study the neurobiology of anxiety has increased in recent years. We assessed the effect of an environmental enrichment (EE) protocol (24h/day over a period of two months) on anxiety-related behaviors when aged Wistar rats (21months old) were confronted with cat odor stimuli. Owing to the relationship between GABAergic interneurons and the anxiety-related neuronal network, we examined changes in the expression of Parvalbumin (PV) and 67kDa form of glutamic acid decarboxylase (GAD-67) immunoreactive cells in different brain regions involved in stress response. Behavioral results revealed that enriched rats traveled further and made more grooming behaviors during the habituation session. In the cat odor session, they traveled longer distances and they showed more active interaction with the odor stimuli and less time in freezing behavior. Zone analysis revealed that the enriched group spent more time in the intermediate zone according to the proximity of the predator odor. Regarding the neurobiological data, the EE increased the expression of PV-positive cells in some medial prefrontal regions (cingulate (Cg) and prelimbic (PL) cortices), whereas the GAD-67 expression in the basolateral amygdala was reduced in the enriched group. Our results suggest that EE is able to reduce anxiety-like behaviors in aged animals even when ethologically relevant stimuli are used. Moreover, GABAergic interneurons could be involved in mediating this resilient behavior.

  17. In Vivo Pharmacological Evaluations of Novel Olanzapine Analogues in Rats: A Potential New Avenue for the Treatment of Schizophrenia

    PubMed Central

    Jafari, Somayeh; Huang, Xu-Feng; Andrews, Jessica L.; Fernandez-Enright, Francesca

    2013-01-01

    Olanzapine (Olz) is one of the most effective antipsychotic drugs commonly used for treating schizophrenia. Unfortunately, Olz administration is associated with severe weight gain and metabolic disturbances. Both patients and clinicians are highly interested in the development of new antipsychotics which are as effective as atypical antipsychotics but which have a lower propensity to induce metabolic side effects. In the present study, we examined two new derivatives of Olz; OlzEt (2-ethyl-4-(4′-methylpiperazin-1′-yl)-10Hbenzo[b]thieno[2,3-e][1,4]diazepine), and OlzHomo (2-ethyl-4-(4′-methyl-1′,4′-diazepan-1′-yl)-10H-benzo[b]thieno[2,3-e] [1,4]diazepine), for their tendency to induce weight gain in rats. Weight gain and metabolic changes were measured in female Sprague Dawley rats. Animals were treated orally with Olz, OlzEt, OlzHomo (3 or 6 mg/kg/day), or vehicle (n = 8), three times daily at eight-hour intervals for 5 weeks. Furthermore, a phencyclidine (PCP)-treated rat model was used to examine the prevention of PCP-induced hyperlocomotor activity relevant for schizophrenia therapy. Male Sprague Dawley rats were pre-treated with a single dose (3 mg/kg/day) of Olz, OlzEt, OlzHomo, or vehicle (n = 12), for 2 weeks. Locomotor activity was recorded following a subcutaneous injection with either saline or PCP (10 mg/kg). Olz was found to induce weight gain, hyperphagia, visceral fat accumulation, and metabolic changes associated with reduced histamatergic H1 receptor density in the hypothalamus of treated rats. In contrast, OlzEt and OlzHomo presented promising antipsychotic effects, which did not induce weight gain or fat deposition in the treated animals. Behavioural analysis showed OlzEt to attenuate PCP-induced hyperactivity to a level similar to that of Olz; however, OlzHomo showed a lower propensity to inhibit these stereotyped behaviours. Our data suggest that the therapeutic effectiveness of OlzHomo may be delivered at a higher dose than that of Olz and OlzEt. Overall, OlzEt and OlzHomo may offer a better pharmacological profile than Olz for treating patients with schizophrenia. Clinical trials are needed to test this hypothesis. PMID:24349027

  18. Constraints, synergies and avenues for scaling up breastfeeding, antibiotics for pneumonia and IMCI interventions in the Cusco region, Peru

    PubMed Central

    Gericke, Christian A

    2012-01-01

    Objective: The purpose of this qualitative case study was to assess the feasibility of scaling up exclusive breastfeeding for 6 months, antibiotics for pneumonia and integrated management of childhood illness (IMCI) child interventions in three districts of the Cusco region, Peru. Methods: During field visits, constraints, synergies and solutions to the implementation of the selected interventions were collected through observational recording and interviews of mothers, health workers, and health managers/decision makers. Results are presented for each intervention according to the health system level where they occurred: mother/community, health worker, health centre, and political/managerial levels. Findings: This case study demonstrates that it is feasible to scale up exclusive breastfeeding, antibiotics for pneumonia and IMCI interventions in poverty-stricken rural areas of a low-income country. Factors that helped and hindered the implementation were identified for each intervention. Conclusions: The need for a coherent multi-sector approach that includes regulation, implementation and monitoring of health policies and education of all involved stakeholders was apparent. This study also demonstrates that global health interventions need to undergo local adaptation. Identifying local constraints and facilitating factors in a systematic way as proposed in this study is a useful step to increase their effectiveness and reach at the local level and to identify areas for improvement in the original intervention policies. PMID:24358831

  19. The Use of Several Diverse Methodologies for Increasing Pupil Achievement: Wesley Avenue Elementary School, 1972-73.

    ERIC Educational Resources Information Center

    Russell, Gail; Gaskin, Comer

    Since many of the children attending Wesley School come from homes which have a low income base, it qualifies for federally funded compensatory services. The educational program at Wesley was unique in that the various compensatory programs in operation reflected the use of several diverse methodologies for improving pupil achievement. The total…

  20. A new avenue to cure cancer by turning adaptive immune T cells to innate immune NK cells via reprogramming.

    PubMed

    Su, Dong-Ming; Vankayalapati, Ramakrishna

    2010-10-01

    Thymocytes after T-lineage commitment develop in the T-cell pathway. However, in a recent study, Li et al. (2010) demonstrated that inducing to delete Bcl11b gene in these thymocytes, even in mature T cells turns these cells into natural killer (NK) cells during the culture. They called this conversion 'reprogramming', and the reprogrammed killer cells 'ITNK cells'. The ITNK cells possessed tumor-killer ability and did not indiscriminately kill normal cells. This exciting finding represents a major breakthrough towards curing cancer and identifies an important, novel transcription factor in the thymus development.

  1. The emerging role of epigenetics in pulmonary arterial hypertension: an important avenue for clinical trials (2015 Grover Conference Series).

    PubMed

    Huston, Jessica H; Ryan, John J

    2016-09-01

    Epigenetics is an emerging field of research and clinical trials in cancer therapy that also has applications for pulmonary arterial hypertension (PAH), as there is evidence that epigenetic control of gene expression plays a significant role in PAH. The three types of epigenetic modification include DNA methylation, histone modification, and RNA interference. All three have been shown to be involved in the development of PAH. Currently, the enzymes that perform these modifications are the primary targets of neoplastic therapy. These targets are starting to be explored for therapies in PAH, mostly in animal models. In this review we summarize the basics of each type of epigenetic modification and the known sites and molecules involved in PAH, as well as current targets and prospects for clinical trials.

  2. Radiological assessment report for the Lansdowne property, 105-107 East Stratford Avenue, Lansdowne, Pennsylvania, October-December 1984

    SciTech Connect

    Wynveen, R.A.; Smith, W.H.; Sholeen, C.M.; Flynn, K.F.

    1985-09-01

    Areas with elevated levels of radioactivity were found throughout both residences, as well as on the surrounding property. Contamination was also found in the garage behind the 105 East structure. The 105 East residence had substantially more contamination than the 107 East residence, as was expected. The chimneys, particularly the rear chimney, from the 105 East residence had extensive contamination, indicating that contaminated materials may have been burned at the site. The high background radiation emanating from this residence made it difficult to establish the relatively lower levels of contamination in the 107 East residence. The property surrounding the 105 East residence was found to have substantial contamination scattered throughout, with the highest level occurring in the backyard. The soil surface contamination seemed to drop markedly (but not entirely) at the property lines. The property surrounding 107 East was found to be less contaminated, although the background radiation emanating from the adjoining area made it difficult to establish the degree of surface or near-surface contamination from surface surveys. Subsurface investigation of the soil surrounding the structure indicated that radium contamination was widespread and extended to a depth of eight feet at some locations. There was evidence that some of this contamination extended onto adjoining properties and may have been transported off the site via subsurface migration. Additionally, analysis of samples from access points in the residence sewer system effluent established that the system was contaminated. 3 refs., 26 figs., 13 tabs.

  3. Super Searchers on Madison Avenue: Top Advertising and Marketing Professionals Share Their Online Research Strategies. Super Searchers, Volume XI.

    ERIC Educational Resources Information Center

    Villamora, Grace Avellana

    This book presents interviews with 13 research professionals that contain favorite online search strategies and research tools, anecdotes, "how to" survival tips, and best-practice examples. The appendix lists referenced sites and sources in the following categories: (1) online resources; (2) books, annuals, newsletters, magazines, and…

  4. Long-range interactions from the many-pair expansion: A different avenue to dispersion in DFT

    NASA Astrophysics Data System (ADS)

    de Silva, Piotr; Zhu, Tianyu; Van Voorhis, Troy

    2017-01-01

    One of the several problems that plague majority of density functional theory calculations is their inability to properly account for long-range correlations giving rise to dispersion forces. The recently proposed many-pair expansion (MPE) [T. Zhu et al., Phys. Rev. B 93, 201108(R) (2016)] is a hierarchy of approximations that systematically corrects any deficiencies of an approximate functional to finally converge to the exact energy. This is achieved by decomposing the total density into a sum of two-electron densities and accounting for successive two-, four-, six-,… electron interactions. Here, we show that already low orders of MPE expansion recover the dispersion energy accurately. To this end, we employ the Pariser-Parr-Pople Hamiltonian and study the behavior of long-range interactions in trans-polyacetylene as well as stacks of ethylene and benzene molecules. We also show how convergence of the expansion is affected by electron conjugation and the choice of the density partitioning.

  5. Pathway activation profiling reveals new insights into age-related macular degeneration and provides avenues for therapeutic interventions.

    PubMed

    Makarev, Evgeny; Cantor, Charles; Zhavoronkov, Alex; Buzdin, Anton; Aliper, Alexander; Csoka, Anotonei Benjamin

    2014-12-01

    Age-related macular degeneration (AMD) is a major cause of blindness in older people and is caused by loss of the central region of the retinal pigment epithelium (RPE). Conventional methods of gene expression analysis have yielded important insights into AMD pathogenesis, but the precise molecular pathway alterations are still poorly understood. Therefore we developed a new software program, "AMD Medicine", and discovered differential pathway activation profiles in samples of human RPE/choroid from AMD patients and controls. We identified 29 pathways in RPE-choroid AMD phenotypes: 27 pathways were activated in AMD compared to controls, and 2 pathways were activated in controls compared to AMD. In AMD, we identified a graded activation of pathways related to wound response, complement cascade, and cell survival. Also, there was downregulation of two pathways responsible for apoptosis. Furthermore, significant activation of pro-mitotic pathways is consistent with dedifferentiation and cell proliferation events, which occur early in the pathogenesis of AMD. Significantly, we discovered new global pathway activation signatures of AMD involved in the cell-based inflammatory response: IL-2, STAT3, and ERK. The ultimate aim of our research is to achieve a better understanding of signaling pathways involved in AMD pathology, which will eventually lead to better treatments.

  6. Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design1

    PubMed Central

    Ilies, Monica; Di Costanzo, Luigi; Dowling, Daniel P.; Thorn, Katherine J.; Christianson, David W.

    2011-01-01

    Arginase is a binuclear manganese metalloenzyme that hydrolyzes L-arginine to form L-ornithine and urea, and aberrant arginase activity is implicated in various diseases such as erectile dysfunction, asthma, atherosclerosis, and cerebral malaria. Accordingly, arginase inhibitors may be therapeutically useful. Continuing our efforts to expand the chemical space of arginase inhibitor design, and inspired by the binding of 2-(difluoromethyl)-L-ornithine to human arginase I, we now report the first study of the binding of α,α-disubstituted amino acids to arginase. Specifically, we report the design, synthesis, and assay of racemic 2-amino-6-borono-2- methylhexanoic acid and racemic 2-amino-6-borono-2-(difluoromethyl)hexanoic acid. X-ray crystal structures of human arginase I and Plasmodium falciparum arginase complexed with these inhibitors reveal the exclusive binding of the L-stereoisomer; the additional α-substituent of each inhibitor is readily accommodated and makes new intermolecular interactions in the outer active site of each enzyme. Therefore, this work highlights a new region of the protein surface that can be targeted for additional affinity interactions, as well as the first comparative structural insights on inhibitor discrimination between a human and a parasitic arginase. PMID:21728378

  7. 75 FR 11916 - Chrysler Group LLC, Formerly Known as Chrysler LLC, Conner Avenue Assembly Plant, Including On...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... automotive components, a substantial portion of which are shipped to an affiliated plant where they are used in the assembly of automotive vehicles. New information shows that workers leased from Caravan...

  8. Innovative Opioid Peptides and Biased Agonism: Novel Avenues for More Effective and Safer Analgesics to Treat Chronic Pain.

    PubMed

    Bedini, Andrea; Spampinato, Santi Mario

    2017-02-15

    Chronic pain is a clinically relevant and yet unsolved conditions that is poorly treated with the currently available drugs, thus highlighting the urgent need of innovative analgesics. Although opiates are not very effective in the treatment of inflammatory and neuropathic pain, developing novel opioid receptor peptide agonists, as well as modulating the opioid receptor-mediated responses in a ligand-specific fashion, may represent an innovative and promising strategy to identify more efficacious and safer antalgic drugs. In this review, novel analogues of endomorphin 1 (a mu opioid receptor selective agonist able to induce analgesia in different animal models of pain - including neuropathic pain) and dermorphin (one of the most potent opioid peptide existing in nature) will be discussed as they are emerging as a promising starting point to develop novel opioid agonists: endomorphin 1 analogues, in fact, may determine antinociception in different models of neuropathic pain with reduced side effects as compared to classic opiates as morphine; dermorphin analogues may elicit analgesia in animal models of both inflammatory and neuropathic pain and with less severe adverse effects. Furthermore, such opioid peptides may allow to explore unprecedented modalities of ligand-receptor interactions, helping to characterize biased agonism at opioid receptors: exploiting functional selectivity at opioid receptor may lead to identify innovative analgesic with improved pharmacological responses and optimized side effects. Thus, innovative opioid peptides, as those outlined in this review, are promising candidates to develop more effective opioid analgesics to be employed as medications for chronic pain states, as inflammatory or neuropathic pain.

  9. Providing an Avenue for Individual Enhancement: The Challenge for Vocational-Technical Education and Training in Nigeria.

    ERIC Educational Resources Information Center

    Khaleel, Ibrahim Adamu

    Nigeria's social and economic conditions at and after independence necessitated changes in educational and employment policy. At independence, in 1960, unification and economic development were necessary to galvanize the country's direction. Control and domination of the economy by foreigners deprived the country of the development of an…

  10. Understanding and Controlling the Aggregative Growth of Platinum Nanoparticles in Atomic Layer Deposition: An Avenue to Size Selection.

    PubMed

    Grillo, Fabio; Van Bui, Hao; Moulijn, Jacob A; Kreutzer, Michiel T; van Ommen, J Ruud

    2017-03-02

    We present an atomistic understanding of the evolution of the size distribution with temperature and number of cycles in atomic layer deposition (ALD) of Pt nanoparticles (NPs). Atomistic modeling of our experiments teaches us that the NPs grow mostly via NP diffusion and coalescence rather than through single-atom processes such as precursor chemisorption, atom attachment, and Ostwald ripening. In particular, our analysis shows that the NP aggregation takes place during the oxygen half-reaction and that the NP mobility exhibits a size- and temperature-dependent scaling. Finally, we show that contrary to what has been widely reported, in general, one cannot simply control the NP size by the number of cycles alone. Instead, while the amount of Pt deposited can be precisely controlled over a wide range of temperatures, ALD-like precision over the NP size requires low deposition temperatures (e.g., T < 100 °C) when growth is dominated by atom attachment.

  11. Electroretinographic modifications induced by agomelatine: a novel avenue to the understanding of the claimed antidepressant effect of the drug?

    PubMed Central

    Fornaro, Michele; Bandini, Fabio; Cestari, Luca; Cordano, Christian; Ogliastro, Carla; Albano, Claudio; De Berardis, Domenico; Martino, Matteo; Escelsior, Andrea; Rocchi, Giulio; Fornaro, Pantaleo; De Pasquale, Concetta

    2014-01-01

    Background Agomelatine, the first melatonergic antidepressant, has been postulated to enhance the dopaminergic activity at the central nervous system by 5-hydroxytryptamine receptor type 2C (5-HT2C) antagonism, yet the impact of melatonergic agonism on this pathway is unclear. Previous studies employing simplified, yet reliable, proxy (retinal) measures of the central nervous system dopaminergic activity, namely the standard electroretinogram (ERG) technique, suggested a reduction of the dopaminergic activity of the main ERG parameter, the b-wave, by pure melatonin, notably a hormone devoid of any antidepressant activity. Therefore, the antidepressant effects of the melatonergic antidepressant drug agomelatine should be reflected by a differential b-wave trend at ERG versus the effect exerted by pure melatonin, which was eventually found to be due to a contrasting effect on central dopaminergic transmission between the two drugs. Objective and methods The aim of the present preliminary ERG study carried out on healthy volunteers (n=23) receiving agomelatine was to explore the impact of this antidepressant drug on b-wave amplitude and latency of cones in daylight conditions using standard ERG. Results As postulated, agomelatine induced an enhancement of retinal dopaminergic activity, in contrast to what has been previously documented for melatonin. Conclusion Given the limits of this explorative study, especially the lack of a control group and that of a luminance response function to measure retinal sensitivity, further studies in clinical samples are recommended to allow more tenable conclusions about the potential role of ERG in discriminating between 5-HT antagonism and melatonergic (MT) agonism in relationship to the claimed antidepressant effect of agomelatine. PMID:24899809

  12. ADNP/NAP dramatically increase microtubule end-binding protein-Tau interaction: a novel avenue for protection against tauopathy.

    PubMed

    Ivashko-Pachima, Y; Sayas, C Laura; Malishkevich, A; Gozes, I

    2017-01-24

    Activity-dependent neuroprotective protein (ADNP), vital for brain formation and cognitive function, is mutated in autism and linked to neurodegenerative/psychiatric diseases. An eight-amino-acid peptide snippet of ADNP, NAP (NAPVSIPQ), identified as a smallest active fragment, includes the SxIP microtubule (MT) end-binding protein (EB) association motif, and enhances ADNP-EB3 interaction. Depletion of EB1 or EB3 abolishes NAP protection against zinc intoxication. Furthermore, NAP enhances Tau-MT interaction, and Tau regulates the localization and function of EB1 and EB3 in developing neuronal cells. Here, we asked how NAP (ADNP) enhances Tau-MT interactions and whether this is mediated by EBs. We showed, for we believe the first time, that NAP augmented endogenous EB1 comet density in the N1E-115 neuroblastoma neuronal model. This finding was substantiated by cell transfection with fluorescent EB1 and live cell imaging. NAP increased comet amounts, length and speed. At the molecular level, NAP enhanced EB3 homodimer formation, while decreasing EB1-EB3 heterodimer content and driving EB1- and EB3-Tau interactions (dramatic 20-fold increases), leading to recruitment of EB1/EB3 and Tau to MTs under zinc intoxication. Our previous results showed that while NAP protected neuronal-like cells against oxidative stress, it did not protect NIH3T3 fibroblasts. Here, NAP did not protect NIH3T3 cells against zinc intoxication, unless these cells were transfected with Tau. Interestingly, other MT associated proteins (MAPs) may replace Tau, thus, EB-Tau (MAPs) interaction is identified as a novel target for endogenous ADNP neuroprotection, and a future target for drug development, with NAP as a prototype.Molecular Psychiatry advance online publication, 24 January 2017; doi:10.1038/mp.2016.255.

  13. Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue?

    PubMed Central

    Titova, Lyubov V.; Ayesheshim, Ayesheshim K.; Golubov, Andrey; Rodriguez-Juarez, Rocio; Woycicki, Rafal; Hegmann, Frank A.; Kovalchuk, Olga

    2013-01-01

    Terahertz (THz) radiation lies between the infrared and microwave regions of the electromagnetic spectrum and is non-ionizing. We show that exposure of artificial human skin tissue to intense, picosecond-duration THz pulses affects expression levels of numerous genes associated with non-melanoma skin cancers, psoriasis and atopic dermatitis. Genes affected by intense THz pulses include nearly half of the epidermal differentiation complex (EDC) members. EDC genes, which are mapped to the chromosomal human region 1q21, encode for proteins that partake in epidermal differentiation and are often overexpressed in conditions such as psoriasis and skin cancer. In nearly all the genes differentially expressed by exposure to intense THz pulses, the induced changes in transcription levels are opposite to disease-related changes. The ability of intense THz pulses to cause concerted favorable changes in the expression of multiple genes implicated in inflammatory skin diseases and skin cancers suggests potential therapeutic applications of intense THz pulses. PMID:23917523

  14. Understanding and Controlling the Aggregative Growth of Platinum Nanoparticles in Atomic Layer Deposition: An Avenue to Size Selection

    PubMed Central

    2017-01-01

    We present an atomistic understanding of the evolution of the size distribution with temperature and number of cycles in atomic layer deposition (ALD) of Pt nanoparticles (NPs). Atomistic modeling of our experiments teaches us that the NPs grow mostly via NP diffusion and coalescence rather than through single-atom processes such as precursor chemisorption, atom attachment, and Ostwald ripening. In particular, our analysis shows that the NP aggregation takes place during the oxygen half-reaction and that the NP mobility exhibits a size- and temperature-dependent scaling. Finally, we show that contrary to what has been widely reported, in general, one cannot simply control the NP size by the number of cycles alone. Instead, while the amount of Pt deposited can be precisely controlled over a wide range of temperatures, ALD-like precision over the NP size requires low deposition temperatures (e.g., T < 100 °C) when growth is dominated by atom attachment. PMID:28178779

  15. The emerging role of epigenetics in pulmonary arterial hypertension: an important avenue for clinical trials (2015 Grover Conference Series)

    PubMed Central

    Ryan, John J.

    2016-01-01

    Abstract Epigenetics is an emerging field of research and clinical trials in cancer therapy that also has applications for pulmonary arterial hypertension (PAH), as there is evidence that epigenetic control of gene expression plays a significant role in PAH. The three types of epigenetic modification include DNA methylation, histone modification, and RNA interference. All three have been shown to be involved in the development of PAH. Currently, the enzymes that perform these modifications are the primary targets of neoplastic therapy. These targets are starting to be explored for therapies in PAH, mostly in animal models. In this review we summarize the basics of each type of epigenetic modification and the known sites and molecules involved in PAH, as well as current targets and prospects for clinical trials. PMID:27683604

  16. Designing and Developing PET-Based Precision Model in Thyroid Carcinoma: The Potential Avenues for a Personalized Clinical Care.

    PubMed

    Basu, Sandip; Parghane, Rahul Vithalrao

    2017-01-01

    This communication enumerates the current uses and potential areas where PET could be clinically utilized for developing "precision medicine" type model in thyroid carcinoma. (1) In routine clinics, PET imaging (with fluorodeoxyglucose [FDG]) is utilized to investigate patients of differentiated thyroid carcinoma (DTC) with high thyroglobulin and negative iodine scintigraphy (TENIS) and in medullary carcinoma thyroid (MCT) when the tumor markers (eg, calcitonin and carcino embryonic antigen [CEA]) are raised postoperatively (PET with FDG, (68)Ga-DOTA-NOC/TATE, FDOPA). Both are examples of management personalization, where PET-computed tomography (CT) has been found substantially useful in detecting sites of metastatic disease and making decision with regard to feasibility and planning of surgery on an individual patient basis. (2) The next important area of management personalization is in patients of TENIS with metastatic disease not amenable to surgery through examining FDG-PET findings in tandem with radio iodine scan and (68)Ga-DOTA-TATE/NOC PET/CT. Heterogeneous behavior of the metastatic lesions is frequently observed clinically: analyzing the findings of three studies aids in sub-segmenting patients into subgroups and thereby deciding upon the best approach (observation with LT4 suppression vs PRRT vs tyrosine kinase inhibitors) that could be individualized in a given case. (3) In metastatic/inoperable MCT, (68)Ga-DOTA-TATE/NOC PET-CT helps in deciding upon feasibility of targeted PRRT in an individual patient and helps in follow-up and response evaluation. (4) Disease prognostification with FDG-PET is evolving both in DTC and MCT, where FDG avidity would indicate an aggressive biology, though the implication of this from treatment viewpoint is unclear at this point. Conversely, a negative FDG-PET in DTC and TENIS would suggest a favorable prognosis in an individual. (5) Iodine-124 PET/CT has the added potential of obtaining lesional dosimetry compared to the SPECT approach, and could help in selecting appropriate doses on an individual basis.

  17. 75 FR 78978 - Record of Decision for the 158th Fighter Wing's Proposed Realignment of National Guard Avenue and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... Airport, South Burlington, VT ACTION: Notice of Availability (NOA) of a Record of Decision (ROD). SUMMARY... public on August 13, 2010 through a NOA in the Federal Register (Volume 75, Number 156, Page 49487) with... with respect to the proposed Air Force actions analyzed in the Final EIS. Authority: This NOA...

  18. Determining the most important physiological and agronomic traits contributing to maize grain yield through machine learning algorithms: a new avenue in intelligent agriculture.

    PubMed

    Shekoofa, Avat; Emam, Yahya; Shekoufa, Navid; Ebrahimi, Mansour; Ebrahimie, Esmaeil

    2014-01-01

    Prediction is an attempt to accurately forecast the outcome of a specific situation while using input information obtained from a set of variables that potentially describe the situation. They can be used to project physiological and agronomic processes; regarding this fact, agronomic traits such as yield can be affected by a large number of variables. In this study, we analyzed a large number of physiological and agronomic traits by screening, clustering, and decision tree models to select the most relevant factors for the prospect of accurately increasing maize grain yield. Decision tree models (with nearly the same performance evaluation) were the most useful tools in understanding the underlying relationships in physiological and agronomic features for selecting the most important and relevant traits (sowing date-location, kernel number per ear, maximum water content, kernel weight, and season duration) corresponding to the maize grain yield. In particular, decision tree generated by C&RT algorithm was the best model for yield prediction based on physiological and agronomical traits which can be extensively employed in future breeding programs. No significant differences in the decision tree models were found when feature selection filtering on data were used, but positive feature selection effect observed in clustering models. Finally, the results showed that the proposed model techniques are useful tools for crop physiologists to search through large datasets seeking patterns for the physiological and agronomic factors, and may assist the selection of the most important traits for the individual site and field. In particular, decision tree models are method of choice with the capability of illustrating different pathways of yield increase in breeding programs, governed by their hierarchy structure of feature ranking as well as pattern discovery via various combinations of features.

  19. Gender Differences in Expressed Interests in Engineering-Related Fields ACT 30-Year Data Analysis Identified Trends and Suggested Avenues to Reverse Trends

    ERIC Educational Resources Information Center

    Iskander, E. Tiffany; Gore, Paul A., Jr.; Furse, Cynthia; Bergerson, Amy

    2013-01-01

    Historically, women have been underrepresented in the Science, Technology, Engineering, and Math (STEM) fields both as college majors and in the professional community. This disturbing trend, observed in many countries, is more serious and evident in American universities and is reflected in the U.S. workforce statistics. In this article, we…

  20. Solar space heating system at the Seeley G. Mudd Education Building, Pacific School of Religion, 1798 Scenic Avenue, Berkeley California 94708. Final report

    SciTech Connect

    Not Available

    1981-12-01

    Large areas of south facing glass allow winter sunlight to penetrate the building, while overhangs provide summer shading. High ceilings allow deep penetration of this light for space heating and natural lighting. Massive construction stores solar radiation for evening warmth and provides a buffer from extreme temperature fluctuations. Natural ventilation will provide cooling. The system consists of 720 square feet of roof-mounted, liquid, flat plate solar collectors and three 350 gallon fiberglass storage tanks. The acceptance and performance tests are discussed. Also discusseed are: collector selection, construction contract, costs, and economics.

  1. Assessing UST corrective action technologies: Lessons learned about in situ air sparging at the Denison Avenue Site, Cleveland, Ohio. Project report

    SciTech Connect

    Clark, T.R.; Chaudet, R.E.; Johnson, R.L.

    1994-12-01

    In situ air sparging (IAS) has been used at an increasing number of sites to address groundwater contamination. Because of the lack of substantive performance data, however, the actual effectiveness of the system is not known. The EPA Office of Research and Development Risk reduction Engineering Laboratory (ORD RREL) with the EPA Region 5 Office of Underground Storage Tanks, the Ohio State Fire Marshal, and BP Exploration & Oil, Inc. (BP) participated in a field evaluation of an IAS system at a petroleum leaking UST site in Cleveland, Ohio. The purpose of the study was to provide performance data that will be independently evaluated by EPA to better understand IAS effectiveness. The report presents the site and monitoring data provided by BP over a 2-year period. The chemical data indicated an overall decrease of BTEX concentrations in groundwater to nondetectable levels shortly after startup of the IAS system. Variability in the chemical and process data also precludes making any definitive link between the decrease in contaminant concentrations and IAS performance at this site.

  2. To designate the facility of the United States Postal Service located at 16300 Broadway Avenue in Maple Heights, Ohio, as the "Daniel Kondas Post Office".

    THOMAS, 112th Congress

    Rep. Fudge, Marcia L. [D-OH-11

    2011-05-02

    05/13/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy . (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  3. Rare genetic diseases with human lean and/or starvation phenotype open new avenues for obesity and type II diabetes treatment.

    PubMed

    Harosh, Itzik

    2014-01-01

    Treatments of obesity and type II diabetes target often gene functions involved in appetite-satiety, fat and carbohydrate metabolism or thermogenesis. None of these, have provided efficient drug therapy due to a large number of genes involved in weight and energy management, the redundancy of biochemical pathways and the environmental factors. Here I discuss a new approach based on studies of genes/proteins that are associated with human "lean or starvation" phenotype that became very rare in the course of evolution. This approach has led to the identification of the congenital enteropeptidase deficiency gene and the Anderson's Disease gene as a potential targets for obesity and type II diabetes treatment. The advantages of these targets are: 1) they are expressed exclusively in the intestine; 2) they are peripheral targets as opposed to systemic targets; 3) they are not redundant targets. These targets open new hopes for the development of novel drugs for the treatment of common metabolic syndrome.

  4. iDNA from terrestrial haematophagous leeches as a wildlife surveying and monitoring tool - prospects, pitfalls and avenues to be developed.

    PubMed

    Schnell, Ida Bærholm; Sollmann, Rahel; Calvignac-Spencer, Sébastien; Siddall, Mark E; Yu, Douglas W; Wilting, Andreas; Gilbert, M Thomas P

    2015-01-01

    Invertebrate-derived DNA (iDNA) from terrestrial haematophagous leeches has recently been proposed as a powerful non-invasive tool with which to detect vertebrate species and thus to survey their populations. However, to date little attention has been given to whether and how this, or indeed any other iDNA-derived data, can be combined with state-of-the-art analytical tools to estimate wildlife abundances, population dynamics and distributions. In this review, we discuss the challenges that face the application of existing analytical methods such as site-occupancy and spatial capture-recapture (SCR) models to terrestrial leech iDNA, in particular, possible violations of key assumptions arising from factors intrinsic to invertebrate parasite biology. Specifically, we review the advantages and disadvantages of terrestrial leeches as a source of iDNA and summarize the utility of leeches for presence, occupancy, and spatial capture-recapture models. The main source of uncertainty that attends species detections derived from leech gut contents is attributable to uncertainty about the spatio-temporal sampling frame, since leeches retain host-blood for months and can move after feeding. Subsequently, we briefly address how the analytical challenges associated with leeches may apply to other sources of iDNA. Our review highlights that despite the considerable potential of leech (and indeed any) iDNA as a new survey tool, further pilot studies are needed to assess how analytical methods can overcome or not the potential biases and assumption violations of the new field of iDNA. Specifically we argue that studies to compare iDNA sampling with standard survey methods such as camera trapping, and those to improve our knowledge on leech (and other invertebrate parasite) physiology, taxonomy, and ecology will be of immense future value.

  5. Determining the Most Important Physiological and Agronomic Traits Contributing to Maize Grain Yield through Machine Learning Algorithms: A New Avenue in Intelligent Agriculture

    PubMed Central

    Shekoofa, Avat; Emam, Yahya; Shekoufa, Navid; Ebrahimi, Mansour; Ebrahimie, Esmaeil

    2014-01-01

    Prediction is an attempt to accurately forecast the outcome of a specific situation while using input information obtained from a set of variables that potentially describe the situation. They can be used to project physiological and agronomic processes; regarding this fact, agronomic traits such as yield can be affected by a large number of variables. In this study, we analyzed a large number of physiological and agronomic traits by screening, clustering, and decision tree models to select the most relevant factors for the prospect of accurately increasing maize grain yield. Decision tree models (with nearly the same performance evaluation) were the most useful tools in understanding the underlying relationships in physiological and agronomic features for selecting the most important and relevant traits (sowing date-location, kernel number per ear, maximum water content, kernel weight, and season duration) corresponding to the maize grain yield. In particular, decision tree generated by C&RT algorithm was the best model for yield prediction based on physiological and agronomical traits which can be extensively employed in future breeding programs. No significant differences in the decision tree models were found when feature selection filtering on data were used, but positive feature selection effect observed in clustering models. Finally, the results showed that the proposed model techniques are useful tools for crop physiologists to search through large datasets seeking patterns for the physiological and agronomic factors, and may assist the selection of the most important traits for the individual site and field. In particular, decision tree models are method of choice with the capability of illustrating different pathways of yield increase in breeding programs, governed by their hierarchy structure of feature ranking as well as pattern discovery via various combinations of features. PMID:24830330

  6. A Study of Cross-Cultural Communication for U.S. Military Application: Identifying Mind/Minefields and Avenues of Approach

    DTIC Science & Technology

    2001-04-01

    the divine and human nature of Christ was primarily the result of whether you read the Bible in Greek, Syriac or Coptic.33 Franz Boas warns that, “A...29 Franz Boas , “Introduction to the...Culture and Society, ed Ben G. Blount (Cambridge, Massachusetts: Winthrop Publishers, Inc. 1874). Boas , Franz , “Introduction to the Handbook of

  7. In-flight verification of avalanche photodiodes: avenue to a low-cost solution to measure suprathermal particles for future missions

    NASA Astrophysics Data System (ADS)

    Ogasawara, K.; Bonnell, J. W.; Christian, E. R.; Desai, M. I.; Grubbs, G. A., II; Jahn, J. M.; Livi, S. A.; Kanekal, S. G.; Llera, K.; McComas, D. J.; Michell, R.; Samara, M.; Vines, S. K.

    2014-12-01

    Flight operation results and plans of Avalanche Photodiodes (APDs) to measure suprathermal particles (a ~few keV up to ~100s of keV) are summarized in this presentation. Ions and electrons in this energy range play crucial roles in many fundamental processes of space plasmas including particle heating and acceleration, providing source material for the energetic particles accelerated near the Sun, the heliosphere, and in geospace. Characterizing these populations poses serious technical challenges because this energy region lies between the two most commonly used particle detection techniques, i.e., that used by thermal or plasma instruments and by Solid-State Detector (SSD)-based energetic particle telescopes, which are limited by typical SSD threshold energies of >10s keV. Our previous work has already demonstrated that a new type of low-noise, low-threshold Avalanche Photo-Diode (APD) has an intrinsic noise level of 0.9 keV, and can therefore enable high-energy resolution measurements of suprathermal electrons and ions. In addition, APDs provide suitable solutions for space plasma detectors in low-cost missions/platform because of their light-weight, small-size, power-saving features. This study presents two low-cost missions (a sounding rocket and a CubeSat) that implement APDs as particle detectors: (1) The Medium-energy Electron SPectrometer (MESP) sensor aboard a sounding rocket was launched from Poker Flat Research Range on 3 March 2014 as a part of Ground-to-Rocket Electrodynamics-Electrons Correlative Experiment (GREECE) mission. MESP successfully measured the precipitating electrons from 2 to 200 keV in 100-ms time resolution by using 2 APDs and 1 SSD. We show the overall results and the comparison with an MCP-based instrument results. (2) The Miniaturized Electron and pRoton Telescope (MERiT) on the Compact Radiation bElt Explorer (CeREs) to study charged particle dynamics in the Earth's radiation belts. CeREs will be flown as part of a 3U CubeSat in a high-inclination low-Earth orbit in 2015. MERiT is designed to measure suprathermal to relativistic electrons from ~5 keV up to10 MeV, and 4 APDs will be applied to cover the lower portion of the energy range. Along with the calibration efforts, we will present predicted in-orbit performances of these APD detectors in the CeREs mission.

  8. MicroRNAs in Schizophrenia: Implications for Synaptic Plasticity and Dopamine-Glutamate Interaction at the Postsynaptic Density. New Avenues for Antipsychotic Treatment Under a Theranostic Perspective.

    PubMed

    de Bartolomeis, Andrea; Iasevoli, Felice; Tomasetti, Carmine; Buonaguro, Elisabetta F

    2015-12-01

    Despite dopamine-glutamate aberrant interaction that has long been considered a relevant landmark of psychosis pathophysiology, several aspects of these two neurotransmitters reciprocal interaction remain to be defined. The emerging role of postsynaptic density (PSD) proteins at glutamate synapse as a molecular "lego" making a functional hub where different signals converge may add a new piece of information to understand how dopamine-glutamate interaction may work with regard to schizophrenia pathophysiology and treatment. More recently, compelling evidence suggests a relevant role for microRNA (miRNA) as a new class of dopamine and glutamate modulators with regulatory functions in the reciprocal interaction of these two neurotransmitters. Here, we aimed at addressing the following issues: (i) Do miRNAs have a role in schizophrenia pathophysiology in the context of dopamine-glutamate aberrant interaction? (ii) If miRNAs are relevant for dopamine-glutamate interaction, at what level this modulation takes place? (iii) Finally, will this knowledge open the door to innovative diagnostic and therapeutic tools? The biogenesis of miRNAs and their role in synaptic plasticity with relevance to schizophrenia will be considered in the context of dopamine-glutamate interaction, with special focus on miRNA interaction with PSD elements. From this framework, implications both for biomarkers identification and potential innovative interventions will be considered.

  9. Middlesex Sampling Plant environmental report for calendar year 1992, 239 Mountain Avenue, Middlesex, New Jersey. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Middlesex Sampling Plant (MSP) and provides the results for 1992. The site, in the Borough of Middlesex, New Jersey, is a fenced area and includes four buildings and two storage piles that contain 50,800 m{sup 3} of radioactive and mixed hazardous waste. More than 70 percent of the MSP site is paved with asphalt. The MSP facility was established in 1943 by the Manhattan Engineer District (MED) to sample, store, and/or ship uranium, thorium, and beryllium ores. In 1955 the Atomic Energy Commission (AEC), successor to MED, terminated the operation and later used the site for storage and limited sampling of thorium residues. In 1967 AEC activities ceased, onsite structures were decontaminated, and the site was certified for unrestricted use under criteria applicable at that time. In 1980 the US Department of Energy (DOE) initiated a multiphase remedial action project to clean up several vicinity properties onto which contamination from the plant had migrated. Material from these properties was consolidated into the storage piles onsite. Environmental surveillance of MSP began in 1980 when Congress added the site to DOE`s Formerly Utilized Sites Remedial Action Program. The environmental surveillance program at MSP includes sampling networks for radon and thoron in air; external gamma radiation exposure; and radium-226, radium-228, thorium-230, thorium-232, and total uranium in surface water, sediment, and groundwater. Additionally, chemical analyses are performed to detect metals and organic compounds in surface water and groundwater and metals in sediments. This program assists in fulfilling th DOE policy of measuring and monitoring effluents from DOE activities and calculating hypothetical doses.

  10. Maywood Interim Storage Site environmental report for calendar year 1992, 100 West Hunter Avenue, Maywood, New Jersey. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Maywood Interim Storage Site (MISS) and provides the results for 1992. Environmental monitoring of MISS began in 1984, when the site was assigned to DOE by Congress through the Energy and Water Development Appropriations Act and was placed under DOE`s Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP was established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. MISS is part of a National Priorities List (NPL) site. The environmental surveillance program at MISS includes sampling networks for radon and thoron in air; external gamma radiation exposure; and radium-226, radium-228, thorium-232, and total uranium in surface water, sediment, and groundwater. Additionally, chemical analysis includes metals and organic compounds in surface water and groundwater and metals in sediments. This program assists in fulfilling the DOE objective of measuring and monitoring effluents from DOE activities and calculating hypothetical doses to members of the general public. Monitoring results are compared with applicable Environmental Protection Agency (EPA) and state standards, DOE derived concentration guides (DCGs), dose limits, and other DOE requirements. Environmental standards are established to protect public health and the environment. The radiological data for all media sampled support the conclusion that doses to the public are not distinguishable from natural background radiation.

  11. [Practices and interventions related to the work integration of people with a severe mental illness: work outcomes and avenues of research].

    PubMed

    Pachoud, B; Corbière, M

    2014-06-01

    Sustained work integration for people with a severe mental illness or handicap psychique in French (e.g., schizophrenia) is an important issue in our society today. Indeed, work is not only an essential factor in people's social integration but is also a stepping-stone toward recovery for this clientele. Well-defined programs and services related to work integration were developed and studied over the last three decades. Although the work integration of people with severe mental illness has been studied extensively in the Anglo-Saxon literature, the impact of these studies on the traditional beliefs and services in France remains uncertain. In terms of the scope of the studies so far, there has been an initial interest lasting over many years to uncover individual characteristics of people with severe mental illness which would best predict job tenure. Since, studies have been increasingly investigating various supports in order to facilitate the work integration process. These supports can be illustrated as direct supports or accommodations offered in the workplace, as needed, particularly when people with severe mental illness choose to disclose their mental disorder in the workplace. This awareness of the impact of the workplace environment on the work integration of people with a severe mental illness increases the need to find solutions and develop environmentally sensitive clinical strategies to overcome difficulties during the work integration. To illustrate this thematic, in this special issue, we have gathered together studies conducted in different countries but who share the focus on work integration of people with a severe mental illness. To reflect the advancement in this domain, this special issue is divided in three parts. The first part consists of the presentation of different types of vocational programs: supported employment programs, social firms, and hybrid models. Supported employment programs are very well documented in the specialised literature and are recognized as an evidence-based practice across the world to help people get competitive employment. Social firms is an another alternative model for facilitating the work integration of people with severe mental illness but has to date scarcely been studied empirically. Other hybrid vocational programs implemented in Québec (Canada) and France and inspired by supported employment programs and social firms' principles, are also described. The second part of this special issue is related to the presentation of two adjunct clinical interventions for helping people with a severe mental illness in their work integration, and more particularly for increasing job tenure: cognitive remediation and group cognitive behavioral therapy. Cognitive remediation was developed to reduce the impact of cognitive deficits, such as memory or attention, in people with a severe mental illness whereas group cognitive behavioral therapy was developed to change the dysfunctional beliefs and behaviours that might hinder job tenure in people receiving supported employment services. Finally, the third part of this special issue presents two papers on the influence of the workplace, of stakeholders from the organization (e.g., employers, supervisors) and of the work environment on the work integration of people with severe mental illness. The first paper discusses disclosure of the mental illness in the workplace and its positive and negative consequences such as receiving work accommodations and experiencing stigma, respectively. In the last paper, psychological processes during the hiring process are presented to better understand the elements related to discrimination and stigma during the work integration of people with severe mental illness.

  12. Colonie Interim Storage Site environmental report for calendar year 1992, 1130 Central Avenue, Colonie, New York. Formerly Utilized Sites Remedial Action Program (FUSRAP)

    SciTech Connect

    Not Available

    1993-05-01

    This report describes the environmental surveillance program at the Colonie Interim Storage Site (CISS) and provides the results for 1992. The site is located in eastern New York State, approximately 6.4 km (4.0 mi) northwest of downtown Albany. From 1958 to 1984, National Lead (NL) Industries used the facility to manufacture various components from depleted and enriched uranium natural thorium. Environmental monitoring of CISS began in 1984 when Congress added, the site to the US Department of Energy`s (DOE) Formerly Utilized Sites Remedial Action Program (FUSRAP). FUSRAP is a program established to identify and decontaminate or otherwise control sites where residual radioactive materials remain from the early years of the nation`s atomic energy program or from commercial operations causing conditions that Congress has authorized DOE to remedy. The environmental surveillance program at CISS includes sampling networks for external gamma radiation exposure and for thorium-232 and total uranium concentrations in surface water, sediment, and groundwater. Several chemical parameters are also measured in groundwater, including total metals, volatile organics, and water quality parameters. This surveillance program assists in fulfilling the DOE policy of measuring and monitoring effluents from DOE activities and calculating hypothetical doses. Results are compared with applicable Environmental Protection Agency (EPA) and New York State Department of Environmental Conservation (NYSDEC) standards, DOE derived concentration guides (DCGs), dose limits, and other DOE requirements.

  13. Church of England Schools as Centres for Religious Abuse or Avenues for Religious Nurture? (The Rights of Children to Encounter Faith in the School Context)

    ERIC Educational Resources Information Center

    Worsley, Howard

    2008-01-01

    After an overview of the British context in 2005 and its ambivalent attitude to Church schools, this article explores the issues of potential religious abuse, alongside a preferred holistic Christian discipleship. The final section explains how Church schools can operate in a way that encourages Christian nurture and prevent religious abuse. The…

  14. Order Responding to September 27, 2002 Request for the Administrator to Object to the Operating Permit for Consolidated Edison Company's Hudson Avenue Generating Station

    EPA Pesticide Factsheets

    This document may be of assistance in applying the Title V air operating permit regulations. This document is part of the Title V Petition Database available at www2.epa.gov/title-v-operating-permits/title-v-petition-database. Some documents in the database are a scanned or retyped version of a paper photocopy of the original. Although we have taken considerable effort to quality assure the documents, some may contain typographical errors. Contact the office that issued the document if you need a copy of the original.

  15. To designate the facility of the United States Postal Service located at 600 Florida Avenue in Cocoa, Florida, as the "Harry T. and Harriette Moore Post Office".

    THOMAS, 111th Congress

    Rep. Posey, Bill [R-FL-15

    2010-05-27

    12/22/2010 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  16. Modulation of alloimmune response by commensal gut microbiota and potential new avenues to influence the outcome of allogeneic transplantation by modification of the 'gut culture'.

    PubMed

    Kanangat, S

    2017-02-01

    Host defence response against microbial infections was the foundation for the Science of Immunology. Now, we know the mechanisms of such host defence which include innate immune responses that is generally nonspecific but effective in many cases and lead to more specific responses called adaptive immune response. The gene loci of class I, II and III of the major histocompatibility complex (MHC) play a major role in directing the adaptive immune responses by presenting processed antigens to T and B cells to induce appropriate antigen-specific cellular and or humoral immune responses. In humans, these are commonly referred to as human leucocyte antigens class I/II-HLA I/II). The class III region, the gamma region in the MHC complex, is mostly associated with regulation of immune responses along with genes associated with complement activation. The adaptive immune responses are orchestrated by T and B cells that are tuned to respond to antigens that are normally foreign to the body, because these cells are educated to avoid self-antigens by a process of thymic education and selection of the T cells that are mostly non-self-reactive which also helps the B cells in eliciting specific immune responses to non-self-antigens. A by-product of this is the ability of the T and B cells to elicit strong immune responses to foreign HLA/MHC (alloimmune response), which developed into the field of histocompatibility testing for allogeneic transplantation of stem cells and organs. Now, we are beginning to learn that such alloimmune responses can be influenced by the microbiota that symbiotically live in our body especially on the mucosal surfaces and on the skin. This review deals with new and emerging data on how the commensal mucosal and skin microbiota influence the immune homeostasis, and how manipulating the commensal microbiota of the mucosa and skin could influence the survival and long-term functions of the allografts. Also, alterations of the microbiota by the inevitable immunosuppression prior to and following allogeneic transplantation could contribute towards the outcome of the allografts by alloimmune responses generated due to microbial antigen vs HLA cross-reactivity.

  17. Avenues of Entry into the World of Western Art Music: Exposing Students to Western Art Music Informally Is One Way to Promote Appreciation for This Music

    ERIC Educational Resources Information Center

    Szabo, Moira

    2005-01-01

    Throughout the author's teaching career of the last thirty years, he has thought a great deal about how to prepare children for meaningful encounters with Western art music, a type of music that is not normally a part of their listening environments. (Many young people consider it music of the grey-haired generation.) The Western art music he was…

  18. Multiphoton ionization of N2 by the third harmonic of a Nd:YAG laser - A new avenue for air diagnostics

    NASA Technical Reports Server (NTRS)

    Laufer, Gabriel; Krauss, Roland H.; Grinstead, Jay H.

    1991-01-01

    Laser-induced N2 ionization is accomplished using a commercially available Nd:YAG laser, and confirmed by means of ion-collection and spectral measurements. Neutral N2 is excited by six photons of the third harmonic frequency, or 355 nm, and is transformed to an ionized state. The radiation at 355 nm is separated from the fundamental and frequency-doubled Nd:YAG radiation to guarantee monochromatic incident radiation. Intense lines near 391.4 nm are found in the initial laser polarization and for a 90-degree rotation of polarization. The radiation at 391.4 nm is associated with an incoherent laser-induced flourescence process related to an ionized-state transition, and increases quadratically with laser power. A 45-mJ laser pulse focused to a diameter of 17 microns can produce an ion concentration of 3.25 x 10 to the 13th ions/cu cm. The large ion concentration and robust fluorescence signal make this technique an efficient method for time-of-flight velocimetry and in-flight testing.

  19. Archeological Monitoring of the Jackson Avenue to Thalia Street (Phase 1) Floodwall Project in the City of New Orleans, Orleans Parish, Louisiana

    DTIC Science & Technology

    1988-06-03

    Louisiana. The project area is located on a point bar upriver from the Vieux Carre, where continuous lateral accretion has increased the land area on the...floodwall alignment right-of-way is located on a point bar upriver from the Vieux Carre. With the exception of occasional and minor riverbank erosion...battles over the ownership of the batture land began in 1820 with the Livingston case in Faubourg St. Marie . Edward Livingston and Jean Gravier began

  20. Modulation of electron tunneling in a nanoparticle array by sound waves: an avenue to high-speed, high-sensitivity sensors.

    PubMed

    Berry, Vikas; Saraf, Ravi F

    2011-09-05

    Using an electrostatic self-assembly process, metal nanoparticles are deposited on polyelectrolyte fibers such that the interparticle distance between the nanoparticles is comparable to the polyelectrolyte's molecular width. By modulating the dielectric properties of the interparticle polymer layer, a highly sensitive, reversible humidity sensor with an ultrafast response time of ≈3 ms is demonstrated. The higher sensitivity at low humidity shows a conductivity increase by over two orders of magnitude in response to a change in relative humidity from 21 to 1%.

  1. To designate the facility of the United States Postal Service located at 1449 West Avenue in Bronx, New York, as the "Private Isaac T. Cortes Post Office".

    THOMAS, 111th Congress

    Rep. Crowley, Joseph [D-NY-7

    2010-09-23

    12/22/2010 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  2. To designate the United States courthouse located at 222 West 7th Avenue in Anchorage, Alaska, as the "James M. Fitzgerald United States Courthouse".

    THOMAS, 112th Congress

    Rep. Young, Don [R-AK-At Large

    2011-10-13

    10/14/2011 Referred to the Subcommittee on Economic Development, Public Buildings and Emergency Management. (All Actions) Notes: For further action, see S.1710, which became Public Law 112-101 on 3/14/2012. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  3. To designate the facility of the United States Postal Service located at 630 Northeast Killingsworth Avenue in Portland, Oregon, as the "Dr. Martin Luther King, Jr. Post Office".

    THOMAS, 111th Congress

    Rep. Blumenauer, Earl [D-OR-3

    2009-06-19

    10/19/2009 Committee on Homeland Security and Governmental Affairs referred to Subcommittee on Federal Financial Management, Government Information, Federal Services, and International Security. (All Actions) Notes: For further action, see S.1314, which became Public Law 111-111 on 11/30/2009. Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  4. To designate the facility of the United States Postal Service located at 2271 Lake Avenue in Altadena, California, as the "First Lieutenant Oliver Goodall Post Office".

    THOMAS, 112th Congress

    Rep. Schiff, Adam B. [D-CA-29

    2011-02-14

    02/18/2011 Referred to the Subcommittee on Federal Workforce, U.S. Postal Service, and Labor Policy . (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  5. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy.

    PubMed Central

    Daughton, Christian G

    2003-01-01

    Since the 1980s, the occurrence of pharmaceuticals and personal care products (PPCPs) as trace environmental pollutants, originating primarily from consumer use and actions rather than manufacturer effluents, continues to become more firmly established. Although PPCPs typically have been identified in surface and ground waters, some are also undoubtedly associated with solid phases such as suspended particulates, sediments, and sewage sludges, despite their relatively high affinity for water. Often amenable to degradation, their continual introduction to waste-receiving waters results from their widespread, continuous, combined use by individuals and domestic animals, giving PPCPs a "pseudo-persistence" in the environment. Little is known about the environmental or human health hazards that might be posed by chronic, subtherapeutic levels of these bioactive substances or their transformation products. The continually growing, worldwide importance of freshwater resources, however, underscores the need for ensuring that any aggregate or cumulative impacts on (or from) water supplies are minimized. Despite the paucity of effects data from long-term, simultaneous exposure at low doses to multiple xenobiotics (particularly non-target-organism exposure to PPCPs), a wide range of proactive actions could be implemented to reduce or minimize the introduction of PPCPs to the environment. Most of these actions fall under what could be envisioned as a holistic stewardship program--overseen by the health care industry and consumers alike. Significantly, such a stewardship program would benefit not just the environment; additional, collateral benefits could automatically accrue, including reducing consumers' medication expenses and improving patient health and consumer safety. In this article, the first of a two-part mini-monograph describing the "green pharmacy," I focus initially on the background behind the imperative for an ecologically oriented stewardship program for PPCPs. I then present a broad spectrum of possible source control/reduction actions, controlled largely by the health care industry, that could minimize the disposition of PPCPs to the environment. This two-part mini-monograph attempts to capture cohesively for the first time the wide spectrum of actions available for minimizing the release of PPCPs to the environment. A major objective is to generate an active dialog or debate across the many disciplines that must become actively involved to design and implement a successful approach to life-cycle stewardship of PPCPs. PMID:12727606

  6. Predicting the Weather and Building the Boats: Full Service Schools as One Avenue to School Success for All of America's Children

    ERIC Educational Resources Information Center

    Kronick, Robert F.

    2003-01-01

    This article describes the evolution of full service schools. Full service schools stress prevention, collaboration and systems change. Prevention is geared toward corrections, mental health and welfare, all topics of keen interest to people working in and studying criminal justice. By providing mental health services at the school for both…

  7. Hydraulic Model Investigation. Effects of Wave Action on a Hurricane Protection Structure for London Avenue Outfall Canal, Lake Pontchartrain New Orleans, Louisiana.

    DTIC Science & Technology

    1987-08-01

    Information Technology Laboratory, WES. COL D. G. Lee, CE, was Commander and Director of WES during the prepara- tion and publication of the report. Dr... MOBL LANPOI Al NE CHADELEUR )$EN OORLEANS 1 I.’ 3* i-I T 0A’M x INOEX --. LI~iTS I I * AI Figure~~~~~~~ 2. LoainoWodnAeu ufl aaI 5I.N RT f~~~C wraft

  8. Interactive Read-Alouds--An Avenue for Enhancing Children's Language for Thinking and Understanding: A Review of Recent Research

    ERIC Educational Resources Information Center

    Lennox, Sandra

    2013-01-01

    Enhancing young children's early literacy achievement is a top priority in many countries. There is a considerable body of research demonstrating young children's language development as a critical factor in reading and later academic success. Implementation of high quality literacy instruction has the potential to improve literacy…

  9. To redesignate the facility of the United States Postal Service located at 2777 Logan Avenue in San Diego, California, as the "Cesar E. Chavez Post Office".

    THOMAS, 111th Congress

    Rep. Davis, Susan A. [D-CA-53

    2009-03-31

    03/31/2009 Referred to the House Committee on Oversight and Government Reform. (All Actions) Notes: For further action, see S.748, which became Public Law 111-109 on 11/30/2009. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  10. Superfund Record of Decision (EPA Region 2): Nascolite Corporation, Doris Avenue, cities of Millville and Vineland, Cumberland County, NJ. (Second remedial action), June 1991. Final report

    SciTech Connect

    Not Available

    1991-06-28

    The 17.5-acre Nascolite site is an inactive acrylic and plexiglass sheet manufacturing plant in Millville, Cumberland County, New Jersey. The site lies within the New Jersey coastal plain and overlies clay, silt, sand, and gravel layers. The majority of the site is wooded, with a wetland located in the southwestern portion. In 1980, although the State ordered the plant to stop discharging wastewaters into the onsite drainage ditch, well water monitoring conducted during 1981 identified VOC-contamination in these wells. In 1984, the State identified over one hundred 55-gallon drums and several underground storage tanks buried onsite. In 1987, the State ordered Nascolite to remove some of the drums, and later during 1987 and 1988, EPA removed the remaining drums offsite. The ROD addresses contaminated onsite soil, sediment, and buildings. The primary contaminant of concern affecting the soil, sediment, and debris is the inorganic contaminant lead; and VOCs including benzene, PCE, TCE, toluene, and xylenes. The selected remedial action for the site is included.

  11. Managing Sino-U.S. Air and Naval Interactions: Cold War Lessons and New Avenues of Approach (INSS China Strategic Perspectives, Number 5, September 2012)

    DTIC Science & Technology

    2012-09-01

    China’s EEZ have highlighted this issue: ■■ the April 2001 collision between a U.S. Navy EP-3 aircraft and a People’s Liberation Army Navy Air Force J-8...the EP-3 incident, the Chinese pilot’s maneuvers resulted in a collision that damaged the EP-3 and resulted in the loss of the Chinese aircraft and...International Regulations for Preventing Collisions at Sea (COLREGs). Promulgated by the International Maritime Or- ganization, COLREGs are

  12. The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery.

    PubMed

    Aouizerat, Bradley E; Pearce, C Leigh; Miaskowski, Christine

    2011-03-01

    Though pursuit of host genetic factors that influence the pathogenesis of HIV began over two decades ago, progress has been slow. Initial genome-level searches for variations associated with HIV-related traits have yielded interesting candidates, but less in the way of novel pathways to be exploited for therapeutic targets. More recent genome-wide association studies (GWAS) that include different phenotypes, novel designs, and that have examined different population characteristics suggest novel targets and affirm the utility of additional searches. Recent findings from these GWAS are reviewed, new directions for research are identified, and the promise of systems biology to yield novel insights is discussed.

  13. Global calcium transducer P-type Ca²⁺-ATPases open new avenues for agriculture by regulating stress signalling.

    PubMed

    Huda, Kazi Md Kamrul; Banu, Mst Sufara Akhter; Tuteja, Renu; Tuteja, Narendra

    2013-08-01

    Food security is in danger under the continuous growing threat of various stresses including climate change and global warming, which ultimately leads to a reduction in crop yields. Calcium plays a very important role in many signal transduction pathways including stress signalling. Different extracellular stimuli trigger increases in cytosolic calcium, which is detrimental to plants. To cope with such stresses, plants need to develop efficient efflux mechanisms to maintain ionic homeostasis. The Ca(2+)-ATPases are members of the P-type ATPase superfamily, which perform many fundamental processes in organisms by actively transporting ions across cellular membranes. In recent years, many studies have revealed that, as well as efflux mechanisms, Ca(2+)-ATPases also play critical roles in sensing calcium fluctuations and relaying downstream signals by activating definitive targets, thus modulating corresponding metabolic pathways. As calcium-activated calmodulin (CaM) is reported to play vital roles in stress tolerance, the presence of a unique CaM-binding site in type IIB Ca(2+)-ATPases indicates their potential role in biotic as well as abiotic stress tolerance. The key roles of Ca(2+)-ATPases in transport systems and stress signalling in cellular homeostasis are addressed in this review. A complete understanding of plant defence mechanisms under stress will allow bioengineering of improved crop plants, which will be crucial for food security currently observed worldwide in the context of global climate changes. Overall, this article covers classification, evolution, structural aspects of Ca(2+)-ATPases, and their emerging roles in plant stress signalling.

  14. Preliminary Final Environmental Assessment: Proposed Upgrades at the 6th Avenue, Mississippi, and Telluride Entry Control Facilities Buckley Air Force Base, Colorado

    DTIC Science & Technology

    2008-05-01

    Parts 1500 -1580, and Air Force policy and procedures (32 CFR Part 989). Purpose and Need: The upgrades are being proposed to improve base security...Environmental Quality (CEQ) regulations for implementing the procedural provisions of NEPA (40 Code of Federal Regulations [CFR] Parts 1500 -1508), and Air...and Telluride Gates WP/29-May-08//056-08 Buckley AFB, Colorado EXPLANATION 0 2 4 Miles AIR FORCE RESERVA T /ON Regional Map Figure 1-1 WP

  15. Grand Forks - East Grand Forks Urban Water Resources Study. Grand Forks Flood Fight Manual

    DTIC Science & Technology

    1981-07-01

    Road and 8th Avenue South Almonte Avenue and 8th Avenue South Belmont Road and 10th Avenue South Reeves Drive and 10th Avenue South Almonte Avenue...and 10th Avenue South Belmont Road and 11th Avenue South Reeves Drive and 11th Avenue South Midway Reeves Drive and Almonte and lltn Avenue South...Belmont Road and 13th Avenue South Belmont Road and 15th Avenue South Belmont Road and 17th Avenue South Lincoln Drive and Almonte Avenue Lincoln

  16. 7 CFR 301.51-3 - Quarantined areas.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Street; then south on 106th Street to Liberty Avenue; then west on Liberty Avenue to Euclid Avenue; then south on Euclid Avenue to Linden Boulevard; then west on Linden Boulevard to Canton Avenue; then west...

  17. 7 CFR 301.51-3 - Quarantined areas.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Street; then south on 106th Street to Liberty Avenue; then west on Liberty Avenue to Euclid Avenue; then south on Euclid Avenue to Linden Boulevard; then west on Linden Boulevard to Canton Avenue; then west...

  18. 7 CFR 301.51-3 - Quarantined areas.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Street; then south on 106th Street to Liberty Avenue; then west on Liberty Avenue to Euclid Avenue; then south on Euclid Avenue to Linden Boulevard; then west on Linden Boulevard to Canton Avenue; then west...

  19. A bill to redesignate the facility of the United States Postal Service located at 162 Northeast Avenue in Tallmadge, Ohio, as the "Lance Corporal Daniel Nathan Deyarmin, Jr., Post Office Building".

    THOMAS, 113th Congress

    Sen. Brown, Sherrod [D-OH

    2014-05-12

    05/12/2014 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Notes: For further action, see H.R.1813, which became Public Law 113-140 on 7/25/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  20. A bill to designate the facility of the United States Postal Service located at 2000 Louisiana Avenue in New Orleans, Louisiana, as the "Roy Rondeno, Sr. Post Office Building".

    THOMAS, 111th Congress

    Sen. Landrieu, Mary L. [D-LA

    2009-12-11

    05/25/2010 Held at the desk. (All Actions) Notes: For further action, see H.R.3951, which became Public Law 111-193 on 6/28/2010. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  1. A bill to designate the facility of the United States Postal Service located at 14 Red River Avenue North in Cold Spring, Minnesota, as the "Officer Tommy Decker Memorial Post Office".

    THOMAS, 113th Congress

    Sen. Klobuchar, Amy [D-MN

    2014-06-18

    06/18/2014 Read twice and referred to the Committee on Homeland Security and Governmental Affairs. (All Actions) Notes: For further action, see H.R.43, which became Public Law 113-204 on 12/16/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  2. National Program of Inspection of Non-Federal Dams, Tennessee. 8th Avenue Reservoir (Inventory Number TN 03719), Cumberland River Basin, Nashville, Davidson County, Tennessee. Phase I Investigation Report,

    DTIC Science & Technology

    1981-09-01

    conditions, such as cavities, loss and r;igration of drill water and dye from place to place, etc. We pr-sume that the drilling was done by skilled...quarter points. These, too, must nut be disturbed. The holes prepared for instrumentation are being regularly "read" with a Digitilt Sensor blaxial...seismic risk areca atid is sandi- tticmi, I ct (It il 2 UI’III 1l -1 l , t (GA), Franklin, Tenn., to appraise the wihted by Zone 2 contours (Zone 0 beitng

  3. New insights into estrogenic regulation of O(6)-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O(6)-benzylguanine indicates fresh avenues for therapy.

    PubMed

    Paranjpe, Ameya; Bailey, Nathan I; Konduri, Santhi; Bobustuc, George C; Ali-Osman, Francis; Yusuf, Mohd A; Punganuru, Surendra R; Madala, Hanumantha Rao; Basak, Debasish; Mostofa, Agm; Srivenugopal, Kalkunte S

    2016-09-01

    Endocrine therapy using estrogen receptor-α (ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers. To exploit any DNA repair deficiencies associated with endocrine therapy, we investigated the functional and physical interactions of ER-α with O(6)-methylguanine DNA methyltransferase (MGMT), a unique DNA repair protein that confers tumor resistance to various anticancer alkylating agents. The ER-α -positive breast cancer cell lines (MCF-7, T47D) and ER- negative cell lines (MDAMB-468, MDAMB-231), and established inhibitors of ER-α and MGMT, namely, ICI-182,780 (Faslodex) and O(6)-benzylguanine, respectively, were used to study MGMT- ER interactions. The MGMT gene promoter was found to harbor one full and two half estrogen-responsive elements (EREs) and two antioxidant-responsive elements (AREs). MGMT expression was upregulated by estrogen, downregulated by tamoxifen in Western blot and promoter-linked reporter assays. Similarly, both transient and stable transfections of Nrf-2 (nuclear factor-erythroid 2-related factor-2) increased the levels of MGMT protein and activity 3 to 4-fold reflecting novel regulatory nodes for this drug-resistance determinant. Of the different ER-α antagonists tested, the pure anti-estrogen fulvestrant was most potent in inhibiting the MGMT activity in a dose, time and ER-α dependent manner, similar to O(6)-benzylguanine. Interestingly, fulvestrant exposure led to a degradation of both ER-α and MGMT proteins and O(6)-benzylguanine also induced a specific loss of ER-α and MGMT proteins in MCF-7 and T47D breast cancer cells with similar kinetics. Immunoprecipitation revealed a specific association of ER-α and MGMT proteins in breast cancer cells. Furthermore, silencing of MGMT gene expression triggered a decrease in the levels of both MGMT and ER-α proteins. The involvement of proteasome in the drug-induced degradation of both proteins was also demonstrated. Fulvestrant enhanced the cytotoxicity of MGMT-targeted alkylating agents, namely, temozolomide and BCNU by 3 to 4-fold in ER-α positive cells, but not in ER-negative cells. We conclude that MGMT and ER-α proteins exist as a complex and are co-targeted for ubiquitin-conjugation and subsequent proteasomal degradation. The findings offer a clear rationale for combining alkylating agents with endocrine therapy.

  4. To designate the Federal building and United States courthouse located at 224 South Boulder Avenue in Tulsa, Oklahoma, as the "H. Dale Cook Federal Building and United States Courthouse".

    THOMAS, 111th Congress

    Rep. Sullivan, John [R-OK-1

    2009-07-23

    11/18/2009 Received in the Senate and Read twice and referred to the Committee on Environment and Public Works. (All Actions) Tracker: This bill has the status Passed HouseHere are the steps for Status of Legislation:

  5. A bill to require the designation of the federally occupied building located at McKinley Avenue and Third Street, S.W., Canton, Ohio, as the "Ralph Regula Federal Office Building and Courthouse".

    THOMAS, 111th Congress

    Sen. Brown, Sherrod [D-OH

    2009-01-15

    10/19/2009 For further action see P.L. 111-74 (H.R. 1687). (All Actions) Notes: For further action, see H.R.1687, which became Public Law 111-74 on 10/19/2009. Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  6. A bill to designate the facility of the United States Postal Service located at 216 Westwood Avenue in Westwood, New Jersey, as the "Sergeant Christopher R. Hrbek Post Office Building".

    THOMAS, 111th Congress

    Sen. Lautenberg, Frank R. [D-NJ

    2010-02-22

    05/18/2010 Placed on Senate Legislative Calendar under General Orders. Calendar No. 383. (All Actions) Notes: For further action, see H.R.4628, which became Public Law 111-189 on 6/9/2010. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  7. To designate the medical center of the Department of Veterans Affairs located at 3900 Woodland Avenue in Philadelphia, Pennsylvania, as the "Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center".

    THOMAS, 113th Congress

    Rep. Fattah, Chaka [D-PA-2

    2013-02-04

    02/08/2013 Referred to the Subcommittee on Health. (All Actions) Notes: For further action, see S.229, which became Public Law 113-230 on 12/16/2014. Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  8. Health coaching and genomics-potential avenues to elicit behavior change in those at risk for chronic disease: protocol for personalized medicine effectiveness study in air force primary care.

    PubMed

    Vorderstrasse, Allison A; Ginsburg, Geoffrey S; Kraus, William E; Maldonado, Maj Carlos J; Wolever, Ruth Q

    2013-05-01

    背景: 2 型糖尿病 (T2D) 及冠心 病 (CHD) 是军人普遍不能幸免的 慢性疾病。虽然已经确定这些疾 病的许多遗传标记,但尚未确立 对这些多因性疾病进行遗传风险 检测的临床应用。同时,尚未探 索进行行为干预(如在 T2D 或 CHD 风险咨询干预之后进行健康辅 导)的必要。我们在此提出对现 役美国空军 (AF) 退休人员和受益 者的遗传风险检测和健康辅导的 临床应用进行评估的理论依据、 设计和方案。主要研究目标:将健康辅导和提 供遗传风险信息加入 CHD 和 T2D 健康行为和临床风险标记的标准 风险咨询中,确定其直接和相互 影响。设计: 4 组(2 X 2 阶乘)随机 对照试验。环境: 美国西海岸的两处 AF 基 础护理临床设施。参与者:成年 AF 基础护理患者。干预: 所有参加者将到临床提供 者处进行风险咨询就诊,讨论个 人 T2D 和 CHD 的风险因素。一半 的参与者(两组)也将在风险咨 询期间得知其 T2D 和 CHD 的遗传 风险测试结果。随机分配至接受 健康辅导两组的参与者随后将接 受逾 6 个月的电话健康辅导。主要结果测量指标: 行为测量指 标(自我报告的饮食摄入、体力 活动、戒烟、药物依从性);临 床结果(AF 综合健身分数、体 重、腰围、血压、空腹血糖、血 脂、T2D/CHD 风险分数)以及心理 测量指标(自我效能、忧虑、感 知风险)将于基线期及 6 周、3 、6 和 12 个月内收集。结论: 本研究对部署在现有 AF 基础护理中的新策略进行测试, 通过患者参与和自我管理支持的 方法,加强坚持有据

  9. National Dam Inspection Program. Stanford Avenue Stormwater Retention Pond (NDI Number PA-01146, DER Number 6-467), Delaware River Basin, Tributary to Wyomissing Creek, Berks County, Pennsylvania. Phase I Inspection Report

    DTIC Science & Technology

    1981-07-01

    refusal and six borings were drilled 10 feet into rock. Laboratory testinq included phvsical properties and compaction tests. Borrow materials from...be given to installing a trash rack at the low level outlet in the event that the fence should fail during a large storm oermitting large debris to...DAM STABILITY SEEPAGE STUDIES MATERIALS INVESTIGATIONS BORING RECORDS LABORATORY Complete records are located in FIELD the Township Engineer’s files

  10. To designate the buildings occupied by the Department of Transportation located at 1200 New Jersey Avenue, Southeast, in the District of Columbia as the "James L. Oberstar United States Department of Transportation Building Complex".

    THOMAS, 113th Congress

    Rep. Lipinski, Daniel [D-IL-3

    2014-05-09

    05/12/2014 Referred to the Subcommittee on Economic Development, Public Buildings and Emergency Management. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  11. Cognitive Deterioration and Associated Pathology Induced by Chronic Low-Level Aluminum Ingestion in a Translational Rat Model Provides an Explanation of Alzheimer's Disease, Tests for Susceptibility and Avenues for Treatment

    PubMed Central

    Walton, J. R.

    2012-01-01

    A translational aging rat model for chronic aluminum (Al) neurotoxicity mimics human Al exposure by ingesting Al, throughout middle age and old age, in equivalent amounts to those ingested by Americans from their food, water, and Al additives. Most rats that consumed Al in an amount equivalent to the high end of the human total dietary Al range developed severe cognitive deterioration in old age. High-stage Al accumulation occurred in the entorhinal cortical cells of origin for the perforant pathway and hippocampal CA1 cells, resulting in microtubule depletion and dendritic dieback. Analogous pathological change in humans leads to destruction of the perforant pathway and Alzheimer's disease dementia. The hippocampus is thereby isolated from neocortical input and output normally mediated by the entorhinal cortex. Additional evidence is presented that Al is involved in the formation of neurofibrillary tangles, amyloid plaques, granulovacuolar degeneration, and other pathological changes of Alzheimer's disease (AD). The shared characteristics indicate that AD is a human form of chronic Al neurotoxicity. This translational animal model provides fresh strategies for the prevention, diagnosis, and treatment of AD. PMID:22928148

  12. N(ω)-Carbamoylation of the Argininamide Moiety: An Avenue to Insurmountable NPY Y1 Receptor Antagonists and a Radiolabeled Selective High-Affinity Molecular Tool ([(3)H]UR-MK299) with Extended Residence Time.

    PubMed

    Keller, Max; Weiss, Stefan; Hutzler, Christoph; Kuhn, Kilian K; Mollereau, Catherine; Dukorn, Stefanie; Schindler, Lisa; Bernhardt, Günther; König, Burkhard; Buschauer, Armin

    2015-11-25

    Analogues of the argininamide-type NPY Y1 receptor (Y1R) antagonist BIBP3226, bearing carbamoyl moieties at the guanidine group, revealed subnanomolar Ki values and caused depression of the maximal response to NPY (calcium assay) by up to 90% in a concentration- and time-dependent manner, suggesting insurmountable antagonism. To gain insight into the mechanism of binding of the synthesized compounds, a tritiated antagonist, (R)-N(α)-diphenylacetyl-N(ω)-[2-([2,3-(3)H]propionylamino)ethyl]aminocarbonyl-(4-hydroxybenzyl)arginin-amide ([(3)H]UR-MK299, [(3)H]38), was prepared. [(3)H]38 revealed a dissociation constant in the picomolar range (Kd 0.044 nM, SK-N-MC cells) and very high Y1R selectivity. Apart from superior affinity, a considerably lower target off-rate (t1/2 95 min) was characteristic of [(3)H]38 compared to that of the higher homologue containing a tetramethylene instead of an ethylene spacer (t1/2 3 min, Kd 2.0 nM). Y1R binding of [(3)H]38 was fully reversible and fully displaceable by nonpeptide antagonists and the agonist pNPY. Therefore, the insurmountable antagonism observed in the functional assay has to be attributed to the extended target-residence time, a phenomenon of relevance in drug research beyond the NPY receptor field.

  13. 34. AERIAL VIEW OF ARROYO SECO PARKWAY, SOUTH PASADENA ROAD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    34. AERIAL VIEW OF ARROYO SECO PARKWAY, SOUTH PASADENA ROAD CUT: GRAND AVENUE BRIDGE, ORANGE GROVE AVENUE BRIDGE; PROSPECT AVENUE BRIDGE; MERIDIAN AVENUE BRIDGE. LOOKING NE. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  14. HARVEST STATES GRAIN COOPERATIVES, SUPERIOR WISCONSIN; CONSTRUCTED OVER VARIOUS DATES ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HARVEST STATES GRAIN COOPERATIVES, SUPERIOR WISCONSIN; CONSTRUCTED OVER VARIOUS DATES BEGINNING IN 1942; LEFT SLIP (HUGHITT AVENUE) RIGHT SLIP (TOWER AVENUE) - Cenex-Harvest States Grain Cooperatives, Dock Street between Hughitt Avenue & Tower Avenue slips, Superior, Douglas County, WI

  15. 12. Oblique view of station from northwest at corner of ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. Oblique view of station from northwest at corner of Stillwell Avenue and Neptune Avenue. Looking southeast. - Stillwell Avenue Station, Intersection of Stillwell & Surf Avenues, Brooklyn, Kings County, NY

  16. 1. OBLIQUE VIEW LOOKING WEST FROM 21ST STREET VIADUCT (SOUTHSIDE) ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. OBLIQUE VIEW LOOKING WEST FROM 21ST STREET VIADUCT (SOUTHSIDE) 2000 BLOCK OF MORRIS AVENUE AND HEAVIEST CORNER ON EARTH DISTRICT AT FIRST AVENUE NORTH AND 20TH STREET (CENTER TOP) - Morris Avenue Warehouse District, 2000-2400 blocks of Morris Avenue & 2100-2500 blocks of First Avenue, North, Birmingham, Jefferson County, AL

  17. Can the "musical stroop" task replace the classical stroop task? Commentary on “The musical Stroop effect: Opening a new avenue to research on automatisms” by l. Grégoire, P. Perruchet, and B. Poulin-Charronnat (Experimental Psychology, 2013, vol. 60, pp. 269–278).

    PubMed

    Zakay, Dan

    2014-01-01

    The musical Stroop task is analyzed and compared to the classical Stroop task. The analysis indicates that the two tasks differ in the following significant characteristics: ecological validity, the interrelations between the two perceptual dimensions involved, the nature of the automatic process and the existence of a potential Garner interference. It is concluded that the musical task has no advantage over the classical task.

  18. How automatic is the musical stroop effect? Commentary on “the musical stroop effect: opening a new avenue to research on automatisms” by l. Grégoire, P. Perruchet, and B. Poulin-Charronnat (Experimental Psychology, 2013, vol. 60, pp. 269–278).

    PubMed

    Moeller, Birte; Frings, Christian

    2014-01-01

    Grégoire, Perruchet, and Poulin-Charronnat (2013) investigated a musical variant of the reversed Stroop effect. According to the authors, one big advantage of this variant is that the automaticity of note naming can be better controlled than in other Stroop variants as musicians are very practiced in note reading whereas non-musicians are not. In this comment we argue that at present the exact impact of automaticity in this Stroop variant remains somewhat unclear for at least three reasons, namely due to the type of information that is automatically retrieved when notes are encountered, due to the possible influence of object-based attention, and finally due to the fact that the exact influence of expertise on interference cannot be pinpointed with an extreme group design.

  19. What is learned, and when? Commentary on “the musical stroop effect: opening a new avenue to research on automatisms” by l. Grégoire, P. Perruchet, and B. Poulin-Charronnat (Experimental Psychology, 2013, vol. 60, pp. 269–278).

    PubMed

    Gast, Anne

    2014-01-01

    In the musical Stroop task, which has recently been introduced by Grégoire, Perruchet, and Poulin-Charronat (2013), participants respond to note names that are placed inside musical notes. Musicians respond more slowly to note names that are incongruent with the note than to note names that are congruent with the note. Grégoire et al. propose to use this task to study the acquisition of automaticity by relating musical Stroop effects to the amount of musical experience. I discuss some caveats that have to be considered for these types of analyses. Specifically, I focus on how different contingencies in the learning situation relate to the Stroop effect and on the question whether a long-term perspective is suitable for studying the acquisition of automaticity.

  20. TOWER S389, MAGAZINES IN BACKGROUND. Naval Magazine Lualualei, West ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TOWER S389, MAGAZINES IN BACKGROUND. - Naval Magazine Lualualei, West Loch Branch, Guard-Watch Tower Type, Near A Avenue between Fourth & Sixth Streets, Ninth Street & D Avenue intersection, & F Avenue, Pearl City, Honolulu County, HI

  1. TOWER 450 WITH POLE. Naval Magazine Lualualei, West Loch ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TOWER 450 WITH POLE. - Naval Magazine Lualualei, West Loch Branch, Guard-Watch Tower Type, Near A Avenue between Fourth & Sixth Streets, Ninth Street & D Avenue intersection, & F Avenue, Pearl City, Honolulu County, HI

  2. TOWER S389, WITH POLE. MAGAZINES IN BACKGROUND. Naval Magazine ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TOWER S389, WITH POLE. MAGAZINES IN BACKGROUND. - Naval Magazine Lualualei, West Loch Branch, Guard-Watch Tower Type, Near A Avenue between Fourth & Sixth Streets, Ninth Street & D Avenue intersection, & F Avenue, Pearl City, Honolulu County, HI

  3. TOWER 450. Naval Magazine Lualualei, West Loch Branch, GuardWatch ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    TOWER 450. - Naval Magazine Lualualei, West Loch Branch, Guard-Watch Tower Type, Near A Avenue between Fourth & Sixth Streets, Ninth Street & D Avenue intersection, & F Avenue, Pearl City, Honolulu County, HI

  4. VIEW OF THE REAR OF WATERSIDE MALL Southwest Washington, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF THE REAR OF WATERSIDE MALL - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  5. CLOSE VIEW ALONG WATERFRONT TO SHOW BULKHEAD Southwest Washington, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    CLOSE VIEW ALONG WATERFRONT TO SHOW BULKHEAD - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  6. INTERIOR VIEW, WATERSIDE MALL Southwest Washington, Urban Renewal Area, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR VIEW, WATERSIDE MALL - Southwest Washington, Urban Renewal Area, Bounded by Independence Avenue, Washington Avenue, South Capitol Street, Canal Street, P Street, Maine Avenue & Washington Channel, Fourteenth Street, D Street, & Twelfth Street, Washington, District of Columbia, DC

  7. Brookland Site Development Study, Brookland, bounded by B&O Railroad Tracks, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Brookland Site Development Study, Brookland, bounded by B&O Railroad Tracks, Rhode Island & Brentwood Avenues on the south, 18th Street & South Dakota Avenue on the east, and Michigan Avenue on the North, Washington, District of Columbia, DC

  8. 35. AERIAL VIEW OF ARROYO SECO PARKWAY, SOUTH PASADENA ROAD ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    35. AERIAL VIEW OF ARROYO SECO PARKWAY, SOUTH PASADENA ROAD CUT AT ORANGE GROVE AVENUE BRIDGE; PROSPECT AVENUE BRIDGE; MERIDIAN AVENUE BRIDGE. LOOKING NE. - Arroyo Seco Parkway, Los Angeles to Pasadena, Los Angeles, Los Angeles County, CA

  9. Contextual view showing northwest corner of building 46, looking down ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view showing northwest corner of building 46, looking down California Avenue; camera facing southwest. - Mare Island Naval Shipyard, Smithery, California Avenue, west side at California Avenue & Eighth Street, Vallejo, Solano County, CA

  10. Contextual view showing new wing and north portion of building ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    Contextual view showing new wing and north portion of building 46, looking down California Avenue; camera facing northwest. - Mare Island Naval Shipyard, Smithery, California Avenue, west side at California Avenue & Eighth Street, Vallejo, Solano County, CA

  11. VIEW OF ROOSEVELT BASE TAKEN FROM ARCADE (BUILDING 234), FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    VIEW OF ROOSEVELT BASE TAKEN FROM ARCADE (BUILDING 234), FACING EAST LOOKING DOWN PRATT AVENUE TOWARD BUILDING 1 - Roosevelt Base, Bounded by Ocean Boulevard, Pennsylvania Avenue, Richardson Avenue, & Idaho Street, Long Beach, Los Angeles County, CA

  12. 77 FR 24925 - Privacy Act of 1974; System of Records

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... Agriculture, George Washington Carver Center, Building 1, Room 2248, 5601 Sunnyside Avenue, Beltsville, MD... Branch (MSB), Portals Building, 1280 Maryland Avenue SW., Washington, DC 20024. Categories of individuals... Maryland Avenue SW., Washington, DC 20024. Notification procedure: Individuals seeking notification of...

  13. 1. General view to southwest showing proximity of house to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. General view to southwest showing proximity of house to bridge and north elevation of house. - Locke Avenue Bridge, Bridge Tender's House, East side of Locke Avenue, 12 feet south of Locke Avenue Bridge, Swedesboro, Gloucester County, NJ

  14. 4. South (left) and east (right) elevations. View to northwest. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. South (left) and east (right) elevations. View to northwest. - Locke Avenue Bridge, Bridge Tender's House, East side of Locke Avenue, 12 feet south of Locke Avenue Bridge, Swedesboro, Gloucester County, NJ

  15. 3. West (left) and south (right) elevations. View to northeast. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. West (left) and south (right) elevations. View to northeast. - Locke Avenue Bridge, Bridge Tender's House, East side of Locke Avenue, 12 feet south of Locke Avenue Bridge, Swedesboro, Gloucester County, NJ

  16. 78 FR 28280 - Operating Limitations at Newark Liberty International Airport

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-14

    ... Organization, Federal Aviation Administration, 800 Independence Avenue SW., Washington, DC 20591; telephone..., 800 Independence Avenue SW., Washington, DC 20591; telephone: (202) 267- 7143; facsimile: (202) 267... Aviation Administration, Office of Rulemaking, ARM-1, 800 Independence Avenue SW., Washington, DC 20591,...

  17. 36 CFR 903.3 - Procedures for notification of records pertaining to individuals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... PENNSYLVANIA AVENUE DEVELOPMENT CORPORATION PRIVACY ACT § 903.3 Procedures for notification of records... the Privacy Protection Officer, Pennsylvania Avenue Development Corporation, 1331 Pennsylvania Avenue... identity of the individual involved without additional proof....

  18. ARROYO SECO PARKWAY SOUTHBOUND LANES AND EXIT RAMP TO ORANGE ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    ARROYO SECO PARKWAY SOUTHBOUND LANES AND EXIT RAMP TO ORANGE GROVE AVENUE. ORANGE GROVE AVENUE BRIDGE IN REAR. LOOKING 278°W - Arroyo Seco Parkway, Orange Grove Avenue Bridge, Milepost 30.59, Los Angeles, Los Angeles County, CA

  19. GRANT AVE., FROM SOUTHEAST OF BUILDING #191 (NORTHWEST CORNER OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    GRANT AVE., FROM SOUTHEAST OF BUILDING #191 (NORTHWEST CORNER OF POPE & GRANT AVENUES), LOOKING NORTH-NORTHEAST - Fort Leavenworth, Metropolitan Avenue & Seventh Street, Leavenworth, Leavenworth County, KS

  20. 17. VIEW LOOKING NORTHEAST, SHOWING SORTING AND SHIPPING SHED WITH ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    17. VIEW LOOKING NORTHEAST, SHOWING SORTING AND SHIPPING SHED WITH SAWMILL BEHIND - Ichabod T. Williams & Sons Sawmill & Veneer Plant, Roosevelt Avenue at Carteret Avenue, Carteret, Middlesex County, NJ