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Sample records for 3d blood flow

  1. Building a 3D Virtual Liver: Methods for Simulating Blood Flow and Hepatic Clearance on 3D Structures.

    PubMed

    White, Diana; Coombe, Dennis; Rezania, Vahid; Tuszynski, Jack

    2016-01-01

    In this paper, we develop a spatio-temporal modeling approach to describe blood and drug flow, as well as drug uptake and elimination, on an approximation of the liver. Extending on previously developed computational approaches, we generate an approximation of a liver, which consists of a portal and hepatic vein vasculature structure, embedded in the surrounding liver tissue. The vasculature is generated via constrained constructive optimization, and then converted to a spatial grid of a selected grid size. Estimates for surrounding upscaled lobule tissue properties are then presented appropriate to the same grid size. Simulation of fluid flow and drug metabolism (hepatic clearance) are completed using discretized forms of the relevant convective-diffusive-reactive partial differential equations for these processes. This results in a single stage, uniformly consistent method to simulate equations for blood and drug flow, as well as drug metabolism, on a 3D structure representative of a liver. PMID:27649537

  2. Building a 3D Virtual Liver: Methods for Simulating Blood Flow and Hepatic Clearance on 3D Structures

    PubMed Central

    Rezania, Vahid; Tuszynski, Jack

    2016-01-01

    In this paper, we develop a spatio-temporal modeling approach to describe blood and drug flow, as well as drug uptake and elimination, on an approximation of the liver. Extending on previously developed computational approaches, we generate an approximation of a liver, which consists of a portal and hepatic vein vasculature structure, embedded in the surrounding liver tissue. The vasculature is generated via constrained constructive optimization, and then converted to a spatial grid of a selected grid size. Estimates for surrounding upscaled lobule tissue properties are then presented appropriate to the same grid size. Simulation of fluid flow and drug metabolism (hepatic clearance) are completed using discretized forms of the relevant convective-diffusive-reactive partial differential equations for these processes. This results in a single stage, uniformly consistent method to simulate equations for blood and drug flow, as well as drug metabolism, on a 3D structure representative of a liver. PMID:27649537

  3. Model studies of blood flow in basilar artery with 3D laser Doppler anemometer

    NASA Astrophysics Data System (ADS)

    Frolov, S. V.; Sindeev, S. V.; Liepsch, D.; Balasso, A.; Proskurin, S. G.; Potlov, A. Y.

    2015-03-01

    It is proposed an integrated approach to the study of basilar artery blood flow using 3D laser Doppler anemometer for identifying the causes of the formation and development of cerebral aneurysms. Feature of the work is the combined usage of both mathematical modeling and experimental methods. Described the experimental setup and the method of measurement of basilar artery blood flow, carried out in an interdisciplinary laboratory of Hospital Rechts der Isar of Technical University of Munich. The experimental setup used to simulate the blood flow in the basilar artery and to measure blood flow characteristics using 3D laser Doppler anemometer (3D LDA). Described a method of numerical studies carried out in Tambov State Technical University and the Bakoulev Center for Cardiovascular Surgery. Proposed an approach for sharing experimental and numerical methods of research to identify the causes of the basilar artery aneurysms.

  4. Analysis and dynamic 3D visualization of cerebral blood flow combining 3D and 4D MR image sequences

    NASA Astrophysics Data System (ADS)

    Forkert, Nils Daniel; Säring, Dennis; Fiehler, Jens; Illies, Till; Möller, Dietmar; Handels, Heinz

    2009-02-01

    In this paper we present a method for the dynamic visualization of cerebral blood flow. Spatio-temporal 4D magnetic resonance angiography (MRA) image datasets and 3D MRA datasets with high spatial resolution were acquired for the analysis of arteriovenous malformations (AVMs). One of the main tasks is the combination of the information of the 3D and 4D MRA image sequences. Initially, in the 3D MRA dataset the vessel system is segmented and a 3D surface model is generated. Then, temporal intensity curves are analyzed voxelwise in the 4D MRA image sequences. A curve fitting of the temporal intensity curves to a patient individual reference curve is used to extract the bolus arrival times in the 4D MRA sequences. After non-linear registration of both MRA datasets the extracted hemodynamic information is transferred to the surface model where the time points of inflow can be visualized color coded dynamically over time. The dynamic visualizations computed using the curve fitting method for the estimation of the bolus arrival times were rated superior compared to those computed using conventional approaches for bolus arrival time estimation. In summary the procedure suggested allows a dynamic visualization of the individual hemodynamic situation and better understanding during the visual evaluation of cerebral vascular diseases.

  5. Parallel Adaptive Computation of Blood Flow in a 3D ``Whole'' Body Model

    NASA Astrophysics Data System (ADS)

    Zhou, M.; Figueroa, C. A.; Taylor, C. A.; Sahni, O.; Jansen, K. E.

    2008-11-01

    Accurate numerical simulations of vascular trauma require the consideration of a larger portion of the vasculature than previously considered, due to the systemic nature of the human body's response. A patient-specific 3D model composed of 78 connected arterial branches extending from the neck to the lower legs is constructed to effectively represent the entire body. Recently developed outflow boundary conditions that appropriately represent the downstream vasculature bed which is not included in the 3D computational domain are applied at 78 outlets. In this work, the pulsatile blood flow simulations are started on a fairly uniform, unstructured mesh that is subsequently adapted using a solution-based approach to efficiently resolve the flow features. The adapted mesh contains non-uniform, anisotropic elements resulting in resolution that conforms with the physical length scales present in the problem. The effects of the mesh resolution on the flow field are studied, specifically on relevant quantities of pressure, velocity and wall shear stress.

  6. Flow effects of blood constitutive equations in 3D models of vascular anomalies

    NASA Astrophysics Data System (ADS)

    Neofytou, Panagiotis; Tsangaris, Sokrates

    2006-06-01

    The effects of different blood rheological models are investigated numerically utilizing two three- dimensional (3D) models of vascular anomalies, namely a stenosis and an abdominal aortic aneurysm model. The employed CFD code incorporates the SIMPLE scheme in conjunction with the finite-volume method with collocated arrangement of variables. The approximation of the convection terms is carried out using the QUICK differencing scheme, whereas the code enables also multi-block computations, which are useful in order to cope with the two-block grid structure of the current computational domain. Three non-Newtonian models are employed, namely the Casson, Power-Law and Quemada models, which have been introduced in the past for modelling the rheological behaviour of blood and cover both the viscous as well as the two-phase character of blood. In view of the haemodynamical mechanisms related to abnormalities in the vascular network and the role of the wall shear stress in initiating and further developing of arterial diseases, the present study focuses on the 3D flow field and in particular on the distribution as well as on both low and high values of the wall shear stress in the vicinity of the anomaly. Finally, a comparison is made between the effects of each rheological model on the aforementioned parameters. Results show marked differences between simulating blood as Newtonian and non-Newtonian fluid and furthermore the Power-Law model exhibits different behaviour in all cases compared to the other models whereas Quemada and Casson models exhibit similar behaviour in the case of the stenosis but different behaviour in the case of the aneurysm.

  7. 3D real-time visualization of blood flow in cerebral aneurysms by light field particle image velocimetry

    NASA Astrophysics Data System (ADS)

    Carlsohn, Matthias F.; Kemmling, André; Petersen, Arne; Wietzke, Lennart

    2016-04-01

    Cerebral aneurysms require endovascular treatment to eliminate potentially lethal hemorrhagic rupture by hemostasis of blood flow within the aneurysm. Devices (e.g. coils and flow diverters) promote homeostasis, however, measurement of blood flow within an aneurysm or cerebral vessel before and after device placement on a microscopic level has not been possible so far. This would allow better individualized treatment planning and improve manufacture design of devices. For experimental analysis, direct measurement of real-time microscopic cerebrovascular flow in micro-structures may be an alternative to computed flow simulations. An application of microscopic aneurysm flow measurement on a regular basis to empirically assess a high number of different anatomic shapes and the corresponding effect of different devices would require a fast and reliable method at low cost with high throughout assessment. Transparent three dimensional 3D models of brain vessels and aneurysms may be used for microscopic flow measurements by particle image velocimetry (PIV), however, up to now the size of structures has set the limits for conventional 3D-imaging camera set-ups. On line flow assessment requires additional computational power to cope with the processing large amounts of data generated by sequences of multi-view stereo images, e.g. generated by a light field camera capturing the 3D information by plenoptic imaging of complex flow processes. Recently, a fast and low cost workflow for producing patient specific three dimensional models of cerebral arteries has been established by stereo-lithographic (SLA) 3D printing. These 3D arterial models are transparent an exhibit a replication precision within a submillimeter range required for accurate flow measurements under physiological conditions. We therefore test the feasibility of microscopic flow measurements by PIV analysis using a plenoptic camera system capturing light field image sequences. Averaging across a sequence of

  8. MRI-based aortic blood flow model in 3D ballistocardiography.

    PubMed

    Lejeune, L; Prisk, G K; Nonclercq, A; Migeotte, P-F

    2015-01-01

    Ballistocardiography (BCG) is a non-invasive technique which measures the acceleration of a body induced by cardiovascular activity, namely the force exerted by the beating heart. A one dimensional aortic flow model based on the transmission lines theory is developped and applied to the simulation of three dimensional BCG. A four-element Windkessel model is used to generate the pressure-wave. Using transverse MRI slices of a human subject, a reconstruction of the aorta allows the extraction of parameters used to relate the local change in mass of the 1D flow model to 3D acceleration BCG. Simulated BCG curves are then compared qualitatively with the ensemble average curves of the same subject recorded in sustained microgravity. Confirming previous studies, the main features of the y-axis are well simulated. The simulated z-axis, never attempted before, shows important similarities. The simulated x-axis is less faithful and suggests the presence of reflections. PMID:26737946

  9. Intensity-based quantification of fast retinal blood flow in 3D via high resolution resonant Doppler spectral OCT

    NASA Astrophysics Data System (ADS)

    Michaely, R.; Bachmann, A. H.; Villiger, M. L.; Blatter, C.; Lasser, T.; Leitgeb, R. A.

    2007-07-01

    Resonant Doppler Fourier Domain Optical Coherence Tomography is a functional imaging modality for quantifying fast tissue flow. The method profits from the effect of interference fringe blurring in spectrometer-based FDOCT in the presence of sample motion. If the reference path length is changed in resonance with the Doppler frequency of the sample flow the signals of resting structures will be suppressed whereas the signals of blood flow are enhanced. This allows for an easy extraction of vascularization structure. 3D images of blood vessels at the human optic nerve head are obtained with high axial resolution of 8 μm in air and an imaging speed of 17.400 depth profiles per second. An electro-optic modulator allows controlled reference phase shifting during camera integration. A differential approach is presented for the quantification of fast flows that are un-accessible via standard phase sensitive Doppler analysis. Flow velocity analysis extracts only the axial component which is dependent on the orientation of the vessel with respect to the optical axis. 3D information of the segmented vessel structure is readily used to obtain the flow velocity vectors along the individual vessels and to calculate the true angle-corrected flow speed.

  10. 3D Flow Visualization Using Texture Advection

    NASA Technical Reports Server (NTRS)

    Kao, David; Zhang, Bing; Kim, Kwansik; Pang, Alex; Moran, Pat (Technical Monitor)

    2001-01-01

    Texture advection is an effective tool for animating and investigating 2D flows. In this paper, we discuss how this technique can be extended to 3D flows. In particular, we examine the use of 3D and 4D textures on 3D synthetic and computational fluid dynamics flow fields.

  11. 3D flow focusing for microfluidic flow cytometry with ultrasonics

    NASA Astrophysics Data System (ADS)

    Gnyawali, Vaskar; Strohm, Eric M.; Daghighi, Yasaman; van de Vondervoort, Mia; Kolios, Michael C.; Tsai, Scott S. H.

    2015-11-01

    We are developing a flow cytometer that detects unique acoustic signature waves generated from single cells due to interactions between the cells and ultrasound waves. The generated acoustic waves depend on the size and biomechanical properties of the cells and are sufficient for identifying cells in the medium. A microfluidic system capable of focusing cells through a 10 x 10 μm ultrasound beam cross section was developed to facilitate acoustic measurements of single cells. The cells are streamlined in a hydro-dynamically 3D focused flow in a 300 x 300 μm channel made using PDMS. 3D focusing is realized by lateral sheath flows and an inlet needle (inner diameter 100 μm). The accuracy of the 3D flow focusing is measured using a dye and detecting its localization using confocal microscopy. Each flowing cell would be probed by an ultrasound pulse, which has a center frequency of 375 MHz and bandwidth of 250 MHz. The same probe would also be used for recording the scattered waves from the cells, which would be processed to distinguish the physical and biomechanical characteristics of the cells, eventually identifying them. This technique has potential applications in detecting circulating tumor cells, blood cells and blood-related diseases.

  12. Cerebral Blood Flow Alterations as Assessed by 3D ASL in Cognitive Impairment in Patients with Subcortical Vascular Cognitive Impairment: A Marker for Disease Severity

    PubMed Central

    Sun, Yawen; Cao, Wenwei; Ding, Weina; Wang, Yao; Han, Xu; Zhou, Yan; Xu, Qun; Zhang, Yong; Xu, Jianrong

    2016-01-01

    Abnormal reductions in cortical cerebral blood flow (CBF) have been identified in subcortical vascular cognitive impairment (SVCI). However, little is known about the pattern of CBF reduction in relation with the degree of cognitive impairment. CBF measured with three-dimensional (3D) Arterial Spin Labeling (ASL) perfusion magnetic resonance imaging (MRI) helps detect functional changes in subjects with SVCI. We aimed to compare CBF maps in subcortical ischemic vascular disease (SIVD) subjects with and without cognitive impairment and to detect the relationship of the regions of CBF reduction in the brain with the degree of cognitive impairment according to the z-score. A total of 53 subjects with SVCI and 23 matched SIVD subjects without cognitive impairment (controls), underwent a whole-brain 3D ASL MRI in the resting state. Regional CBF (rCBF) was compared voxel wise by using an analysis of variance design in a statistical parametric mapping program, with patient age and sex as covariates. Correlations were calculated between the rCBF value in the whole brain and the z-score in the 53 subjects with SVCI. Compared with the control subjects, SVCI group demonstrated diffuse decreased CBF in the brain. Significant positive correlations were determined in the rCBF values in the left hippocampus, left superior temporal pole gyrus, right superior frontal orbital lobe, right medial frontal orbital lobe, right middle temporal lobe, left thalamus and right insula with the z-scores in SVCI group. The noninvasively quantified resting CBF demonstrated altered CBF distributions in the SVCI brain. The deficit brain perfusions in the temporal and frontal lobe, hippocampus, thalamus and insula was related to the degree of cognitive impairment. Its relationship to cognition indicates the clinical relevance of this functional marker. Thus, our results provide further evidence for the mechanisms underlying the cognitive deficit in patients with SVCI.

  13. Cerebral Blood Flow Alterations as Assessed by 3D ASL in Cognitive Impairment in Patients with Subcortical Vascular Cognitive Impairment: A Marker for Disease Severity.

    PubMed

    Sun, Yawen; Cao, Wenwei; Ding, Weina; Wang, Yao; Han, Xu; Zhou, Yan; Xu, Qun; Zhang, Yong; Xu, Jianrong

    2016-01-01

    Abnormal reductions in cortical cerebral blood flow (CBF) have been identified in subcortical vascular cognitive impairment (SVCI). However, little is known about the pattern of CBF reduction in relation with the degree of cognitive impairment. CBF measured with three-dimensional (3D) Arterial Spin Labeling (ASL) perfusion magnetic resonance imaging (MRI) helps detect functional changes in subjects with SVCI. We aimed to compare CBF maps in subcortical ischemic vascular disease (SIVD) subjects with and without cognitive impairment and to detect the relationship of the regions of CBF reduction in the brain with the degree of cognitive impairment according to the z-score. A total of 53 subjects with SVCI and 23 matched SIVD subjects without cognitive impairment (controls), underwent a whole-brain 3D ASL MRI in the resting state. Regional CBF (rCBF) was compared voxel wise by using an analysis of variance design in a statistical parametric mapping program, with patient age and sex as covariates. Correlations were calculated between the rCBF value in the whole brain and the z-score in the 53 subjects with SVCI. Compared with the control subjects, SVCI group demonstrated diffuse decreased CBF in the brain. Significant positive correlations were determined in the rCBF values in the left hippocampus, left superior temporal pole gyrus, right superior frontal orbital lobe, right medial frontal orbital lobe, right middle temporal lobe, left thalamus and right insula with the z-scores in SVCI group. The noninvasively quantified resting CBF demonstrated altered CBF distributions in the SVCI brain. The deficit brain perfusions in the temporal and frontal lobe, hippocampus, thalamus and insula was related to the degree of cognitive impairment. Its relationship to cognition indicates the clinical relevance of this functional marker. Thus, our results provide further evidence for the mechanisms underlying the cognitive deficit in patients with SVCI. PMID:27630562

  14. Cerebral Blood Flow Alterations as Assessed by 3D ASL in Cognitive Impairment in Patients with Subcortical Vascular Cognitive Impairment: A Marker for Disease Severity

    PubMed Central

    Sun, Yawen; Cao, Wenwei; Ding, Weina; Wang, Yao; Han, Xu; Zhou, Yan; Xu, Qun; Zhang, Yong; Xu, Jianrong

    2016-01-01

    Abnormal reductions in cortical cerebral blood flow (CBF) have been identified in subcortical vascular cognitive impairment (SVCI). However, little is known about the pattern of CBF reduction in relation with the degree of cognitive impairment. CBF measured with three-dimensional (3D) Arterial Spin Labeling (ASL) perfusion magnetic resonance imaging (MRI) helps detect functional changes in subjects with SVCI. We aimed to compare CBF maps in subcortical ischemic vascular disease (SIVD) subjects with and without cognitive impairment and to detect the relationship of the regions of CBF reduction in the brain with the degree of cognitive impairment according to the z-score. A total of 53 subjects with SVCI and 23 matched SIVD subjects without cognitive impairment (controls), underwent a whole-brain 3D ASL MRI in the resting state. Regional CBF (rCBF) was compared voxel wise by using an analysis of variance design in a statistical parametric mapping program, with patient age and sex as covariates. Correlations were calculated between the rCBF value in the whole brain and the z-score in the 53 subjects with SVCI. Compared with the control subjects, SVCI group demonstrated diffuse decreased CBF in the brain. Significant positive correlations were determined in the rCBF values in the left hippocampus, left superior temporal pole gyrus, right superior frontal orbital lobe, right medial frontal orbital lobe, right middle temporal lobe, left thalamus and right insula with the z-scores in SVCI group. The noninvasively quantified resting CBF demonstrated altered CBF distributions in the SVCI brain. The deficit brain perfusions in the temporal and frontal lobe, hippocampus, thalamus and insula was related to the degree of cognitive impairment. Its relationship to cognition indicates the clinical relevance of this functional marker. Thus, our results provide further evidence for the mechanisms underlying the cognitive deficit in patients with SVCI. PMID:27630562

  15. Cerebral Blood Flow Alterations as Assessed by 3D ASL in Cognitive Impairment in Patients with Subcortical Vascular Cognitive Impairment: A Marker for Disease Severity.

    PubMed

    Sun, Yawen; Cao, Wenwei; Ding, Weina; Wang, Yao; Han, Xu; Zhou, Yan; Xu, Qun; Zhang, Yong; Xu, Jianrong

    2016-01-01

    Abnormal reductions in cortical cerebral blood flow (CBF) have been identified in subcortical vascular cognitive impairment (SVCI). However, little is known about the pattern of CBF reduction in relation with the degree of cognitive impairment. CBF measured with three-dimensional (3D) Arterial Spin Labeling (ASL) perfusion magnetic resonance imaging (MRI) helps detect functional changes in subjects with SVCI. We aimed to compare CBF maps in subcortical ischemic vascular disease (SIVD) subjects with and without cognitive impairment and to detect the relationship of the regions of CBF reduction in the brain with the degree of cognitive impairment according to the z-score. A total of 53 subjects with SVCI and 23 matched SIVD subjects without cognitive impairment (controls), underwent a whole-brain 3D ASL MRI in the resting state. Regional CBF (rCBF) was compared voxel wise by using an analysis of variance design in a statistical parametric mapping program, with patient age and sex as covariates. Correlations were calculated between the rCBF value in the whole brain and the z-score in the 53 subjects with SVCI. Compared with the control subjects, SVCI group demonstrated diffuse decreased CBF in the brain. Significant positive correlations were determined in the rCBF values in the left hippocampus, left superior temporal pole gyrus, right superior frontal orbital lobe, right medial frontal orbital lobe, right middle temporal lobe, left thalamus and right insula with the z-scores in SVCI group. The noninvasively quantified resting CBF demonstrated altered CBF distributions in the SVCI brain. The deficit brain perfusions in the temporal and frontal lobe, hippocampus, thalamus and insula was related to the degree of cognitive impairment. Its relationship to cognition indicates the clinical relevance of this functional marker. Thus, our results provide further evidence for the mechanisms underlying the cognitive deficit in patients with SVCI.

  16. XML3D and Xflow: combining declarative 3D for the Web with generic data flows.

    PubMed

    Klein, Felix; Sons, Kristian; Rubinstein, Dmitri; Slusallek, Philipp

    2013-01-01

    Researchers have combined XML3D, which provides declarative, interactive 3D scene descriptions based on HTML5, with Xflow, a language for declarative, high-performance data processing. The result lets Web developers combine a 3D scene graph with data flows for dynamic meshes, animations, image processing, and postprocessing. PMID:24808080

  17. Complex flow dynamics around 3D microbot prototypes.

    PubMed

    Martínez-Aranda, Sergio; Galindo-Rosales, Francisco J; Campo-Deaño, Laura

    2016-02-28

    A new experimental setup for the study of the complex flow dynamics around 3D microbot prototypes in a straight microchannel has been developed and assessed. The ultimate aim of this work is focused on the analysis of the morphology of different microbot prototypes to get a better insight into their efficiency when they swim through the main conduits of the human circulatory system. The setup consists of a fused silica straight microchannel with a 3D microbot prototype fastened in the center of the channel cross-section by an extremely thin support. Four different prototypes were considered: a cube, a sphere and two ellipsoids with aspect ratios of 1 : 2 and 1 : 4, respectively. Flow visualization and micro-particle image velocimetry (μPIV) measurements were performed using Newtonian and viscoelastic blood analogue fluids. An efficiency parameter, ℑ, to discriminate the prototypes in terms of flow disturbance has been proposed.

  18. Magnetosheath Flow Anomalies in 3-D

    NASA Technical Reports Server (NTRS)

    Vaisberg, O. L.; Burch, J. L.; Smirnov, V. N.; Avanov, L. A.; Moore, T. E.; Waite, J. H., Jr.; Skalsky, A. A.; Borodkova, N. L.; Coffey, V. N.; Gallagher, D. L.; Rose, M. Franklin (Technical Monitor)

    2000-01-01

    Measurements of the plasma and magnetic field with high temporal resolution on the Interball Tail probe reveal many flow anomalies in the magnetosheath. They are usually seen as flow direction and number density variations, accompanied by magnetic field discontinuities. Large flow anomalies with number density variations of factor of 2 or more and velocity variations of 100 km/s or more are seen with periodicity of about I per hour. The cases of flow anomalies following in succession are also observed, and suggest their decay while propagating through the magnetosheath. Some magnetospheric disturbances observed in the outer magnetosphere after the satellite has crossed the magnetopause on the inbound orbit suggest their association with magnetosheath flow anomalies observed in the magnetosheath prior to magnetopause crossing.

  19. Recent Advances in Visualizing 3D Flow with LIC

    NASA Technical Reports Server (NTRS)

    Interrante, Victoria; Grosch, Chester

    1998-01-01

    Line Integral Convolution (LIC), introduced by Cabral and Leedom in 1993, is an elegant and versatile technique for representing directional information via patterns of correlation in a texture. Although most commonly used to depict 2D flow, or flow over a surface in 3D, LIC methods can equivalently be used to portray 3D flow through a volume. However, the popularity of LIC as a device for illustrating 3D flow has historically been limited both by the computational expense of generating and rendering such a 3D texture and by the difficulties inherent in clearly and effectively conveying the directional information embodied in the volumetric output textures that are produced. In an earlier paper, we briefly discussed some of the factors that may underlie the perceptual difficulties that we can encounter with dense 3D displays and outlined several strategies for more effectively visualizing 3D flow with volume LIC. In this article, we review in more detail techniques for selectively emphasizing critical regions of interest in a flow and for facilitating the accurate perception of the 3D depth and orientation of overlapping streamlines, and we demonstrate new methods for efficiently incorporating an indication of orientation into a flow representation and for conveying additional information about related scalar quantities such as temperature or vorticity over a flow via subtle, continuous line width and color variations.

  20. Lattice Boltzmann Method for 3-D Flows with Curved Boundary

    NASA Technical Reports Server (NTRS)

    Mei, Renwei; Shyy, Wei; Yu, Dazhi; Luo, Li-Shi

    2002-01-01

    In this work, we investigate two issues that are important to computational efficiency and reliability in fluid dynamics applications of the lattice, Boltzmann equation (LBE): (1) Computational stability and accuracy of different lattice Boltzmann models and (2) the treatment of the boundary conditions on curved solid boundaries and their 3-D implementations. Three athermal 3-D LBE models (D3QI5, D3Ql9, and D3Q27) are studied and compared in terms of efficiency, accuracy, and robustness. The boundary treatment recently developed by Filippova and Hanel and Met et al. in 2-D is extended to and implemented for 3-D. The convergence, stability, and computational efficiency of the 3-D LBE models with the boundary treatment for curved boundaries were tested in simulations of four 3-D flows: (1) Fully developed flows in a square duct, (2) flow in a 3-D lid-driven cavity, (3) fully developed flows in a circular pipe, and (4) a uniform flow over a sphere. We found that while the fifteen-velocity 3-D (D3Ql5) model is more prone to numerical instability and the D3Q27 is more computationally intensive, the 63Q19 model provides a balance between computational reliability and efficiency. Through numerical simulations, we demonstrated that the boundary treatment for 3-D arbitrary curved geometry has second-order accuracy and possesses satisfactory stability characteristics.

  1. Unsteady 3D flow simulations in cranial arterial tree

    NASA Astrophysics Data System (ADS)

    Grinberg, Leopold; Anor, Tomer; Madsen, Joseph; Karniadakis, George

    2008-11-01

    High resolution unsteady 3D flow simulations in major cranial arteries have been performed. Two cases were considered: 1) a healthy volunteer with a complete Circle of Willis (CoW); and 2) a patient with hydrocephalus and an incomplete CoW. Computation was performed on 3344 processors of the new half petaflop supercomputer in TACC. Two new numerical approaches were developed and implemented: 1) a new two-level domain decomposition method, which couples continuous and discontinuous Galerkin discretization of the computational domain; and 2) a new type of outflow boundary conditions, which imposes, in an accurate and computationally efficient manner, clinically measured flow rates. In the first simulation, a geometric model of 65 cranial arteries was reconstructed. Our simulation reveals a high degree of asymmetry in the flow at the left and right parts of the CoW and the presence of swirling flow in most of the CoW arteries. In the second simulation, one of the main findings was a high pressure drop at the right anterior communicating artery (PCA). Due to the incompleteness of the CoW and the pressure drop at the PCA, the right internal carotid artery supplies blood to most regions of the brain.

  2. Multigrid calculations of 3-D turbulent viscous flows

    NASA Technical Reports Server (NTRS)

    Yokota, Jeffrey W.

    1989-01-01

    Convergence properties of a multigrid algorithm, developed to calculate compressible viscous flows, are analyzed by a vector sequence eigenvalue estimate. The full 3-D Reynolds-averaged Navier-Stokes equations are integrated by an implicit multigrid scheme while a k-epsilon turbulence model is solved, uncoupled from the flow equations. Estimates of the eigenvalue structure for both single and multigrid calculations are compared in an attempt to analyze the process as well as the results of the multigrid technique. The flow through an annular turbine is used to illustrate the scheme's ability to calculate complex 3-D flows.

  3. High-pitch spiral CT with 3D reformation: an alternative choice for imaging vascular anomalies with affluent blood flow in the head and neck of infants and children

    PubMed Central

    Li, H-O; Huo, R; Xu, G-Q; Duan, Y-H; Nie, P; Ji, X-P; Cheng, Z-P; Xu, Z-D

    2015-01-01

    Objective: To evaluate the feasibility of high-pitch spiral CT in imaging vascular anomalies (VAs) with affluent blood flow in the head and neck of infants and children. Methods: For patients with suspected VAs and affluent blood flow pre-detected by ultrasound, CT was performed with high-pitch mode, individualized low-dose scan protocol and three-dimensional (3D) reformation. A five-point scale was used for image quality evaluation. Diagnostic accuracy was calculated with clinical diagnosis with/without pathological results as the reference standard. Radiation exposure and single-phase scan time were recorded. Treatment strategies were formulated based on CT images and results and were monitored through follow-up results. Results: 20 lesions were identified in 15 patients (median age of 11 months). The mean score of image quality was 4.13 ± 0.74. 7 patients (7/15, 46.67%) were diagnosed with haemangiomas, 6 patients (6/15, 40%) were diagnosed with venous malformations and 2 patients (2/15, 13.33%) were diagnosed with arteriovenous malformations. The average effective radiation doses of a single phase and of the total procedure were 0.27 ± 0.08 and 0.86 ± 0.21 mSv. The average scanning time of a single phase was 0.46 ± 0.09 s. After treatment, 13 patients (13/15, 86.67%) achieved excellent results, and 2 patients (2/15, 13.33%) showed good results in follow-up visits. Conclusion: High-pitch spiral CT with an individualized low-dose scan protocol and 3D reformation is an effective modality for imaging VAs with affluent blood flow in the head and neck of infants and children when vascular details are needed and ultrasound and MRI could not provide the complete information. Advances in knowledge: This study proposes an alternative modality for imaging VAs with affluent blood flow. PMID:26055504

  4. Customizable engineered blood vessels using 3D printed inserts.

    PubMed

    Pinnock, Cameron B; Meier, Elizabeth M; Joshi, Neeraj N; Wu, Bin; Lam, Mai T

    2016-04-15

    Current techniques for tissue engineering blood vessels are not customizable for vascular size variation and vessel wall thickness. These critical parameters vary widely between the different arteries in the human body, and the ability to engineer vessels of varying sizes could increase capabilities for disease modeling and treatment options. We present an innovative method for producing customizable, tissue engineered, self-organizing vascular constructs by replicating a major structural component of blood vessels - the smooth muscle layer, or tunica media. We utilize a unique system combining 3D printed plate inserts to control construct size and shape, and cell sheets supported by a temporary fibrin hydrogel to encourage cellular self-organization into a tubular form resembling a natural artery. To form the vascular construct, 3D printed inserts are adhered to tissue culture plates, fibrin hydrogel is deposited around the inserts, and human aortic smooth muscle cells are then seeded atop the fibrin hydrogel. The gel, aided by the innate contractile properties of the smooth muscle cells, aggregates towards the center post insert, creating a tissue ring of smooth muscle cells. These rings are then stacked into the final tubular construct. Our methodology is robust, easily repeatable and allows for customization of cellular composition, vessel wall thickness, and length of the vessel construct merely by varying the size of the 3D printed inserts. This platform has potential for facilitating more accurate modeling of vascular pathology, serving as a drug discovery tool, or for vessel repair in disease treatment. PMID:26732049

  5. Customizable engineered blood vessels using 3D printed inserts.

    PubMed

    Pinnock, Cameron B; Meier, Elizabeth M; Joshi, Neeraj N; Wu, Bin; Lam, Mai T

    2016-04-15

    Current techniques for tissue engineering blood vessels are not customizable for vascular size variation and vessel wall thickness. These critical parameters vary widely between the different arteries in the human body, and the ability to engineer vessels of varying sizes could increase capabilities for disease modeling and treatment options. We present an innovative method for producing customizable, tissue engineered, self-organizing vascular constructs by replicating a major structural component of blood vessels - the smooth muscle layer, or tunica media. We utilize a unique system combining 3D printed plate inserts to control construct size and shape, and cell sheets supported by a temporary fibrin hydrogel to encourage cellular self-organization into a tubular form resembling a natural artery. To form the vascular construct, 3D printed inserts are adhered to tissue culture plates, fibrin hydrogel is deposited around the inserts, and human aortic smooth muscle cells are then seeded atop the fibrin hydrogel. The gel, aided by the innate contractile properties of the smooth muscle cells, aggregates towards the center post insert, creating a tissue ring of smooth muscle cells. These rings are then stacked into the final tubular construct. Our methodology is robust, easily repeatable and allows for customization of cellular composition, vessel wall thickness, and length of the vessel construct merely by varying the size of the 3D printed inserts. This platform has potential for facilitating more accurate modeling of vascular pathology, serving as a drug discovery tool, or for vessel repair in disease treatment.

  6. 3-D ultrafast Doppler imaging applied to the noninvasive mapping of blood vessels in vivo.

    PubMed

    Provost, Jean; Papadacci, Clement; Demene, Charlie; Gennisson, Jean-Luc; Tanter, Mickael; Pernot, Mathieu

    2015-08-01

    Ultrafast Doppler imaging was introduced as a technique to quantify blood flow in an entire 2-D field of view, expanding the field of application of ultrasound imaging to the highly sensitive anatomical and functional mapping of blood vessels. We have recently developed 3-D ultrafast ultrasound imaging, a technique that can produce thousands of ultrasound volumes per second, based on a 3-D plane and diverging wave emissions, and demonstrated its clinical feasibility in human subjects in vivo. In this study, we show that noninvasive 3-D ultrafast power Doppler, pulsed Doppler, and color Doppler imaging can be used to perform imaging of blood vessels in humans when using coherent compounding of 3-D tilted plane waves. A customized, programmable, 1024-channel ultrasound system was designed to perform 3-D ultrafast imaging. Using a 32 × 32, 3-MHz matrix phased array (Vermon, Tours, France), volumes were beamformed by coherently compounding successive tilted plane wave emissions. Doppler processing was then applied in a voxel-wise fashion. The proof of principle of 3-D ultrafast power Doppler imaging was first performed by imaging Tygon tubes of various diameters, and in vivo feasibility was demonstrated by imaging small vessels in the human thyroid. Simultaneous 3-D color and pulsed Doppler imaging using compounded emissions were also applied in the carotid artery and the jugular vein in one healthy volunteer.

  7. 3-D ultrafast Doppler imaging applied to the noninvasive mapping of blood vessels in vivo.

    PubMed

    Provost, Jean; Papadacci, Clement; Demene, Charlie; Gennisson, Jean-Luc; Tanter, Mickael; Pernot, Mathieu

    2015-08-01

    Ultrafast Doppler imaging was introduced as a technique to quantify blood flow in an entire 2-D field of view, expanding the field of application of ultrasound imaging to the highly sensitive anatomical and functional mapping of blood vessels. We have recently developed 3-D ultrafast ultrasound imaging, a technique that can produce thousands of ultrasound volumes per second, based on a 3-D plane and diverging wave emissions, and demonstrated its clinical feasibility in human subjects in vivo. In this study, we show that noninvasive 3-D ultrafast power Doppler, pulsed Doppler, and color Doppler imaging can be used to perform imaging of blood vessels in humans when using coherent compounding of 3-D tilted plane waves. A customized, programmable, 1024-channel ultrasound system was designed to perform 3-D ultrafast imaging. Using a 32 × 32, 3-MHz matrix phased array (Vermon, Tours, France), volumes were beamformed by coherently compounding successive tilted plane wave emissions. Doppler processing was then applied in a voxel-wise fashion. The proof of principle of 3-D ultrafast power Doppler imaging was first performed by imaging Tygon tubes of various diameters, and in vivo feasibility was demonstrated by imaging small vessels in the human thyroid. Simultaneous 3-D color and pulsed Doppler imaging using compounded emissions were also applied in the carotid artery and the jugular vein in one healthy volunteer. PMID:26276956

  8. USM3D Predictions of Supersonic Nozzle Flow

    NASA Technical Reports Server (NTRS)

    Carter, Melissa B.; Elmiligui, Alaa A.; Campbell, Richard L.; Nayani, Sudheer N.

    2014-01-01

    This study focused on the NASA Tetrahedral Unstructured Software System CFD code (USM3D) capability to predict supersonic plume flow. Previous studies, published in 2004 and 2009, investigated USM3D's results versus historical experimental data. This current study continued that comparison however focusing on the use of the volume souring to capture the shear layers and internal shock structure of the plume. This study was conducted using two benchmark axisymmetric supersonic jet experimental data sets. The study showed that with the use of volume sourcing, USM3D was able to capture and model a jet plume's shear layer and internal shock structure.

  9. A stabilized mixed finite element method for shear-rate dependent non-Newtonian fluids: 3D benchmark problems and application to blood flow in bifurcating arteries

    NASA Astrophysics Data System (ADS)

    Kwack, JaeHyuk; Masud, Arif

    2014-04-01

    This paper presents a stabilized mixed finite element method for shear-rate dependent fluids. The nonlinear viscosity field is a function of the shear-rate and varies uniformly in space and in time. The stabilized form is developed via application of Variational Multiscale (VMS) framework to the underlying generalized Navier-Stokes equation. Linear and quadratic tetrahedral and hexahedral elements are employed with equal-order interpolations for the velocity and pressure fields. A variety of benchmark problems are solved to assess the stability and accuracy properties of the resulting method. The method is then applied to non-Newtonian shear-rate dependent flows in bifurcating artery geometry, and significant non-Newtonian fluid effects are observed. A comparative study of the proposed method shows that the additional computational costs due to the nonlinear shear-rate dependent viscosity are only ten percent more than the computational cost for a Newtonian model.

  10. 3D Printed Micro Free-Flow Electrophoresis Device.

    PubMed

    Anciaux, Sarah K; Geiger, Matthew; Bowser, Michael T

    2016-08-01

    The cost, time, and restrictions on creative flexibility associated with current fabrication methods present significant challenges in the development and application of microfluidic devices. Additive manufacturing, also referred to as three-dimensional (3D) printing, provides many advantages over existing methods. With 3D printing, devices can be made in a cost-effective manner with the ability to rapidly prototype new designs. We have fabricated a micro free-flow electrophoresis (μFFE) device using a low-cost, consumer-grade 3D printer. Test prints were performed to determine the minimum feature sizes that could be reproducibly produced using 3D printing fabrication. Microfluidic ridges could be fabricated with dimensions as small as 20 μm high × 640 μm wide. Minimum valley dimensions were 30 μm wide × 130 μm wide. An acetone vapor bath was used to smooth acrylonitrile-butadiene-styrene (ABS) surfaces and facilitate bonding of fully enclosed channels. The surfaces of the 3D-printed features were profiled and compared to a similar device fabricated in a glass substrate. Stable stream profiles were obtained in a 3D-printed μFFE device. Separations of fluorescent dyes in the 3D-printed device and its glass counterpart were comparable. A μFFE separation of myoglobin and cytochrome c was also demonstrated on a 3D-printed device. Limits of detection for rhodamine 110 were determined to be 2 and 0.3 nM for the 3D-printed and glass devices, respectively.

  11. 3D Printed Micro Free-Flow Electrophoresis Device.

    PubMed

    Anciaux, Sarah K; Geiger, Matthew; Bowser, Michael T

    2016-08-01

    The cost, time, and restrictions on creative flexibility associated with current fabrication methods present significant challenges in the development and application of microfluidic devices. Additive manufacturing, also referred to as three-dimensional (3D) printing, provides many advantages over existing methods. With 3D printing, devices can be made in a cost-effective manner with the ability to rapidly prototype new designs. We have fabricated a micro free-flow electrophoresis (μFFE) device using a low-cost, consumer-grade 3D printer. Test prints were performed to determine the minimum feature sizes that could be reproducibly produced using 3D printing fabrication. Microfluidic ridges could be fabricated with dimensions as small as 20 μm high × 640 μm wide. Minimum valley dimensions were 30 μm wide × 130 μm wide. An acetone vapor bath was used to smooth acrylonitrile-butadiene-styrene (ABS) surfaces and facilitate bonding of fully enclosed channels. The surfaces of the 3D-printed features were profiled and compared to a similar device fabricated in a glass substrate. Stable stream profiles were obtained in a 3D-printed μFFE device. Separations of fluorescent dyes in the 3D-printed device and its glass counterpart were comparable. A μFFE separation of myoglobin and cytochrome c was also demonstrated on a 3D-printed device. Limits of detection for rhodamine 110 were determined to be 2 and 0.3 nM for the 3D-printed and glass devices, respectively. PMID:27377354

  12. Joint 3d Estimation of Vehicles and Scene Flow

    NASA Astrophysics Data System (ADS)

    Menze, M.; Heipke, C.; Geiger, A.

    2015-08-01

    driving. While much progress has been made in recent years, imaging conditions in natural outdoor environments are still very challenging for current reconstruction and recognition methods. In this paper, we propose a novel unified approach which reasons jointly about 3D scene flow as well as the pose, shape and motion of vehicles in the scene. Towards this goal, we incorporate a deformable CAD model into a slanted-plane conditional random field for scene flow estimation and enforce shape consistency between the rendered 3D models and the parameters of all superpixels in the image. The association of superpixels to objects is established by an index variable which implicitly enables model selection. We evaluate our approach on the challenging KITTI scene flow dataset in terms of object and scene flow estimation. Our results provide a prove of concept and demonstrate the usefulness of our method.

  13. An annotation system for 3D fluid flow visualization

    NASA Technical Reports Server (NTRS)

    Loughlin, Maria M.; Hughes, John F.

    1995-01-01

    Annotation is a key activity of data analysis. However, current systems for data analysis focus almost exclusively on visualization. We propose a system which integrates annotations into a visualization system. Annotations are embedded in 3D data space, using the Post-it metaphor. This embedding allows contextual-based information storage and retrieval, and facilitates information sharing in collaborative environments. We provide a traditional database filter and a Magic Lens filter to create specialized views of the data. The system has been customized for fluid flow applications, with features which allow users to store parameters of visualization tools and sketch 3D volumes.

  14. Formation of coherent structures in 3D laminar mixing flows

    NASA Astrophysics Data System (ADS)

    Speetjens, Michel; Clercx, Herman

    2009-11-01

    Mixing under laminar flow conditions is key to a wide variety of industrial systems of size extending from microns to meters. Examples range from the traditional (and still very relevant) mixing of viscous fluids via compact processing equipment down to emerging micro-fluidics applications. Profound insight into laminar mixing mechanisms is imperative for further advancement of mixing technology (particularly for complex micro-fluidics systems) yet remains limited to date. The present study concentrates on a fundamental transport phenomenon of potential relevance to laminar mixing: the formation of coherent structures in the web of 3D fluid trajectories due to fluid inertia. Such coherent structures geometrically determine the transport properties of the flow and better understanding of their formation and characteristics may offer ways to control and manipulate the mixing properties of laminar flows. The formation of coherent structures and its impact upon 3D transport properties is demonstrated by way of examples.

  15. A Volume Rendering Framework for Visualizing 3D Flow Fields

    NASA Astrophysics Data System (ADS)

    Hsieh, Hsien-Hsi; Li, Liya; Shen, Han-Wei; Tai, Wen-Kai

    In this paper, we present a volume rendering framework for visualizing 3D flow fields. We introduce the concept of coherence field which evaluates the representativeness of a given streamline set for the underlying 3D vector field. Visualization of the coherence field can provide effective visual feedback to the user for incremental insertion of more streamline seeds. Given an initial set of streamlines, a coherence volume is constructed from a distance field to measure the similarity between the existing streamlines and those in their nearby regions based on the difference between the approximate and the actual vector directions. With the visual feedback obtained from rendering the coherence volume, new streamline seeds can be selected by the user or by a heuristic seed selection algorithm to adaptively improve the coherence volume. An improved volume rendering technique that can render user-defined appearance textures is proposed to facilitate macro-visualization of 3D vector fields.

  16. The 3D Flow Field Around an Embedded Planet

    NASA Astrophysics Data System (ADS)

    Fung, Jeffrey; Artymowicz, Pawel; Wu, Yanqin

    2015-10-01

    3D modifications to the well-studied 2D flow topology around an embedded planet have the potential to resolve long-standing problems in planet formation theory. We present a detailed analysis of the 3D isothermal flow field around a 5 Earth-mass planet on a fixed circular orbit, simulated using our graphics processing unit hydrodynamics code PEnGUIn. We find that, overall, the horseshoe region has a columnar structure extending vertically much beyond the Hill sphere of the planet. This columnar structure is only broken for some of the widest horseshoe streamlines, along which high altitude fluid descends rapidly into the planet’s Bondi sphere, performs one horseshoe turn, and exits the Bondi sphere radially in the midplane. A portion of this flow exits the horseshoe region altogether, which we refer to as the “transient” horseshoe flow. The flow continues as it rolls up into a pair of up-down symmetric horizontal vortex lines shed into the wake of the planet. This flow, unique to 3D, affects both planet accretion and migration. It prevents the planet from sustaining a hydrostatic atmosphere due to its intrusion into the Bondi sphere, and leads to a significant corotation torque on the planet, unanticipated by 2D analysis. In the reported simulation, starting with a {{Σ }}˜ {r}-3/2 radial surface density profile, this torque is positive and partially cancels with the negative differential Lindblad torque, resulting in a factor of three slower planet migration rate. Finally, we report 3D effects can be suppressed by a sufficiently large disk viscosity, leading to results similar to 2D.

  17. Magma rheology from 3D geometry of martian lava flows

    NASA Astrophysics Data System (ADS)

    Allemand, P.; Deschamps, A.; Lesaout, M.; Delacourt, C.; Quantin, C.; Clenet, H.

    2012-04-01

    Volcanism is an important geologic agent which has been recently active at the surface of Mars. The composition of individual lava flows is difficult to infer from spectroscopic data because of the absence of crystallized minerals and the possible cover of the flows by dust. The 3D geometry of lava flows provides an interesting alternative to infer the chemical composition of lavas and effusion rates. Indeed, chemical composition exerts a strong control on the viscosity and yield strength of the magma and global geometry of lava flow reflects its emplacement rate. Until recently, these studies where realized from 2D data. The third dimension, which is a key parameter, was deduced or supposed from local shadow measurements on MGS Themis IR images with an uncertainty of more than 500%. Recent CTX data (MRO mission) allow to compute Digital Elevation Model at a resolution of 1 or 2 pixels (5 to 10 m) with the help of Isis and the Ames Stereo Pipeline pipe line. The CTX images are first transformed in format readable by Isis. The external geometric parameters of the CTX camera are computed and added to the image header with Isis. During a correlation phase, the homologous pixels are searched on the pair of stereo images. Finally, the DEM is computed from the position of the homologous pixels and the geometrical parameters of the CTX camera. Twenty DEM have been computed from stereo images showing lava flows of various ages on the region of Cerberus, Elyseum, Daedalia and Amazonis planitia. The 3D parameters of the lava flows have been measured on the DEMs and tested against shadows measurement. These 3D parameters have been inverted to estimate the viscosity and the yield strength of the flow. The effusion rate has also been estimated. These parameters have been compared to those of similar lava flows of the East Pacific rise.

  18. Finite element solver for 3-D compressible viscous flows

    NASA Technical Reports Server (NTRS)

    Reddy, K. C.; Reddy, J. N.

    1986-01-01

    The space shuttle main engine (SSME) has extremely complex internal flow structure. The geometry of the flow domain is three-dimensional with complicated topology. The flow is compressible, viscous, and turbulent with large gradients in flow quantities and regions of recirculations. The analysis of the flow field in SSME involves several tedious steps. One is the geometrical modeling of the particular zone of the SSME being studied. Accessing the geometry definition, digitalizing it, and developing surface interpolations suitable for an interior grid generator require considerable amount of manual labor. There are several types of grid generators available with some general-purpose finite element programs. An efficient and robust computational scheme for solving 3D Navier-Stokes equations has to be implemented. Post processing software has to be adapted to visualize and analyze the computed 3D flow field. The progress made in a project to develop software for the analysis of the flow is discussed. The technical approach to the development of the finite element scheme and the relaxation procedure are discussed. The three dimensional finite element code for the compressible Navier-Stokes equations is listed.

  19. Assessment of Altered 3D Blood Characteristics in Aortic Disease by Velocity Distribution Analysis

    PubMed Central

    Garcia, Julio; Barker, Alex J; van Ooij, Pim; Schnell, Susanne; Puthumana, Jyothy; Bonow, Robert O; Collins, Jeremy D; Carr, James C; Markl, Michael

    2014-01-01

    Purpose To test the feasibility of velocity distribution analysis for identifying altered 3D flow characteristics in patients with aortic disease based on 4D flow MRI volumetric analysis. Methods Forty patients with aortic (Ao) dilation (mid ascending aortic diameter MAA=40±7 mm, age=56±17 yr, 11 females) underwent cardiovascular MRI. Four groups were retrospectively defined: mild Ao dilation (n=10, MAA<35 mm); moderate Ao dilation (n=10, 3545 mm); Ao dilation+aortic stenosis AS (n=10, MAA>35 mm and peak velocity >2.5m/s). 3D PC-MR angiograms were computed and used to obtain a 3D segmentation of the aorta which was divided into four segments: root, ascending aorta, arch, descending aorta. Radial chart displays were used to visualize multiple parameters representing segmental changes in the 3D velocity distribution associated with aortic disease. Results Changes in the velocity field and geometry between cohorts resulted in distinct hemodynamic patterns for each aortic segment. Disease progression from mild to Ao dilation+AS resulted in significant differences (P<0.05) in flow parameters across cohorts and increased radial chart size for root and ascending aorta segments by 146% and 99%, respectively. Conclusion Volumetric 4D velocity distribution analysis has the potential to identify characteristic changes in regional blood flow patterns in patients with aortic disease. PMID:25252029

  20. Optimization of a Hybrid Magnetic Bearing for a Magnetically Levitated Blood Pump via 3-D FEA

    PubMed Central

    Cheng, Shanbao; Olles, Mark W.; Burger, Aaron F.; Day, Steven W.

    2011-01-01

    In order to improve the performance of a magnetically levitated (maglev) axial flow blood pump, three-dimensional (3-D) finite element analysis (FEA) was used to optimize the design of a hybrid magnetic bearing (HMB). Radial, axial, and current stiffness of multiple design variations of the HMB were calculated using a 3-D FEA package and verified by experimental results. As compared with the original design, the optimized HMB had twice the axial stiffness with the resulting increase of negative radial stiffness partially compensated for by increased current stiffness. Accordingly, the performance of the maglev axial flow blood pump with the optimized HMBs was improved: the maximum pump speed was increased from 6000 rpm to 9000 rpm (50%). The radial, axial and current stiffness of the HMB was found to be linear at nominal operational position from both 3-D FEA and empirical measurements. Stiffness values determined by FEA and empirical measurements agreed well with one another. The magnetic flux density distribution and flux loop of the HMB were also visualized via 3-D FEA which confirms the designers’ initial assumption about the function of this HMB. PMID:22065892

  1. 3-D Flow Visualization of a Turbulent Boundary Layer

    NASA Astrophysics Data System (ADS)

    Thurow, Brian; Williams, Steven; Lynch, Kyle

    2009-11-01

    A recently developed 3-D flow visualization technique is used to visualize large-scale structures in a turbulent boundary layer. The technique is based on the scanning of a laser light sheet through the flow field similar to that of Delo and Smits (1997). High-speeds are possible using a recently developed MHz rate pulse burst laser system, an ultra-high-speed camera capable of 500,000 fps and a galvanometric scanning mirror yielding a total acquisition time of 136 microseconds for a 220 x 220 x 68 voxel image. In these experiments, smoke is seeded into the boundary layer formed on the wall of a low-speed wind tunnel. The boundary layer is approximately 1.5'' thick at the imaging location with a free stream velocity of 24 ft/s yielding a Reynolds number of 18,000 based on boundary layer thickness. The 3-D image volume is approximately 4'' x 4'' x 4''. Preliminary results using 3-D iso-surface visualizations show a collection of elongated large-scale structures inclined in the streamwise direction. The spanwise width of the structures, which are located in the outer region, is on the order of 25 -- 50% of the boundary layer thickness.

  2. Optic flow aided navigation and 3D scene reconstruction

    NASA Astrophysics Data System (ADS)

    Rollason, Malcolm

    2013-10-01

    An important enabler for low cost airborne systems is the ability to exploit low cost inertial instruments. An Inertial Navigation System (INS) can provide a navigation solution, when GPS is denied, by integrating measurements from inertial sensors. However, the gyrometer and accelerometer biases of low cost inertial sensors cause compound errors in the integrated navigation solution. This paper describes experiments to establish whether (and to what extent) the navigation solution can be aided by fusing measurements from an on-board video camera with measurements from the inertial sensors. The primary aim of the work was to establish whether optic flow aided navigation is beneficial even when the 3D structure within the observed scene is unknown. A further aim was to investigate whether an INS can help to infer 3D scene content from video. Experiments with both real and synthetic data have been conducted. Real data was collected using an AR Parrot quadrotor. Empirical results illustrate that optic flow provides a useful aid to navigation even when the 3D structure of the observed scene is not known. With optic flow aiding of the INS, the computed trajectory is consistent with the true camera motion, whereas the unaided INS yields a rapidly increasing position error (the data represents ~40 seconds, after which the unaided INS is ~50 metres in error and has passed through the ground). The results of the Monte Carlo simulation concur with the empirical result. Position errors, which grow as a quadratic function of time when unaided, are substantially checked by the availability of optic flow measurements.

  3. 3D vector flow using a row-column addressed CMUT array

    NASA Astrophysics Data System (ADS)

    Holbek, Simon; Christiansen, Thomas Lehrmann; Engholm, Mathias; Lei, Anders; Stuart, Mathias Bo; Beers, Christopher; Moesner, Lars Nordahl; Bagge, Jan Peter; Thomsen, Erik Vilain; Jensen, Jørgen Arendt

    2016-04-01

    This paper presents an in-house developed 2-D capacitive micromachined ultrasonic transducer (CMUT) applied for 3-D blood flow estimation. The probe breaks with conventional transducers in two ways; first, the ultrasonic pressure field is generated from thousands of small vibrating micromachined cells, and second, elements are accessed by row and/or column indices. The 62+62 2-D row-column addressed prototype CMUT probe was used for vector flow estimation by transmitting focused ultrasound into a flow-rig with a fully developed parabolic flow. The beam-to-flow angle was 90°. The received data was beamformed and processed offline. A transverse oscillation (TO) velocity estimator was used to estimate the 3-D vector flow along a line originating from the center of the transducer. The estimated velocities in the lateral and axial direction were close to zero as expected. In the transverse direction a characteristic parabolic velocity profile was estimated with a peak velocity of 0.48 m/s +/- 0.02 m/s in reference to the expected 0.54 m/s. The results presented are the first 3-D vector flow estimates obtained with a row-column CMUT probe, which demonstrates that the CMUT technology is feasible for 3-D flow estimation.

  4. Blood flow

    MedlinePlus Videos and Cool Tools

    As the heart pumps, the arteries carry oxygen-rich blood (shown in red) away from the heart and toward the body's tissues and vital organs. ... brain, liver, kidneys, stomach, and muscles, including the heart muscle itself. At the same time, the veins ...

  5. Using flow information to support 3D vessel reconstruction from rotational angiography

    SciTech Connect

    Waechter, Irina; Bredno, Joerg; Weese, Juergen; Barratt, Dean C.; Hawkes, David J.

    2008-07-15

    For the assessment of cerebrovascular diseases, it is beneficial to obtain three-dimensional (3D) morphologic and hemodynamic information about the vessel system. Rotational angiography is routinely used to image the 3D vascular geometry and we have shown previously that rotational subtraction angiography has the potential to also give quantitative information about blood flow. Flow information can be determined when the angiographic sequence shows inflow and possibly outflow of contrast agent. However, a standard volume reconstruction assumes that the vessel tree is uniformly filled with contrast agent during the whole acquisition. If this is not the case, the reconstruction exhibits artifacts. Here, we show how flow information can be used to support the reconstruction of the 3D vessel centerline and radii in this case. Our method uses the fast marching algorithm to determine the order in which voxels are analyzed. For every voxel, the rotational time intensity curve (R-TIC) is determined from the image intensities at the projection points of the current voxel. Next, the bolus arrival time of the contrast agent at the voxel is estimated from the R-TIC. Then, a measure of the intensity and duration of the enhancement is determined, from which a speed value is calculated that steers the propagation of the fast marching algorithm. The results of the fast marching algorithm are used to determine the 3D centerline by backtracking. The 3D radius is reconstructed from 2D radius estimates on the projection images. The proposed method was tested on computer simulated rotational angiography sequences with systematically varied x-ray acquisition, blood flow, and contrast agent injection parameters and on datasets from an experimental setup using an anthropomorphic cerebrovascular phantom. For the computer simulation, the mean absolute error of the 3D centerline and 3D radius estimation was 0.42 and 0.25 mm, respectively. For the experimental datasets, the mean absolute

  6. Patterns of 3D flow in a rotating cylinder array

    NASA Astrophysics Data System (ADS)

    Craig, Anna; Dabiri, John; Koseff, Jeffrey

    2015-11-01

    Experimental data are presented for large arrays of rotating, finite-height cylinders, which show that the three-dimensional flows are strongly dependent on the geometric and rotational configurations of the array. Two geometric configurations of the cylinders, each with two rotational configurations, were examined for a total of four arrays. 2D PIV was conducted in multiple intersecting horizontal and vertical sheets at a location far downstream of the leading edge of the array in order to build up a picture of the 3D developed flow patterns. It was found that the rotation of the cylinders drives the formation of streamwise and transverse flow patterns between cylinders. These horizontal flow patterns, by conservation of mass, drive vertical flows through the top of the array. As the array of rotating cylinders may provide insight into the flow kinematics of an array of vertical axis wind turbines, this planform flux is of particular interest as it would bring down into the array high kinetic energy fluid from above the array, thus increasing the energy resource available to turbines far downstream of the leading edge of the array.

  7. MPSalsa 3D Simulations of Chemically Reacting Flows

    DOE Data Explorer

    Many important scientific and engineering applications require a detailed analysis of complex systems with coupled fluid flow, thermal energy transfer, mass transfer and nonequilibrium chemical reactions. Currently, computer simulations of these complex reacting flow problems are limited to idealized systems in one or two spatial dimensions when coupled with a detailed, fundamental chemistry model. The goal of our research is to develop, analyze and implement advanced MP numerical algorithms that will allow high resolution 3D simulations with an equal emphasis on fluid flow and chemical kinetics modeling. In our research, we focus on the development of new, fully coupled, implicit solution strategies that are based on robust MP iterative solution methods (copied from http://www.cs.sandia.gov/CRF/MPSalsa/). These simulations are needed for scientific and technical areas such as: combustion research for transportation, atmospheric chemistry modeling for pollution studies, chemically reacting flow models for analysis and control of manufacturing processes, surface catalytic reactors for methane to methanol conversion and chemical vapor deposition (CVD) process modeling for production of advanced semiconductor materials (http://www.cs.sandia.gov/CRF/MPSalsa/).

    This project website provides six QuickTime videos of these simulations, along with a small image gallery and slideshow animations. A list of related publications and conference presentations is also made available.

  8. Modeling Electric Current Flow in 3D Fractured Media

    NASA Astrophysics Data System (ADS)

    Demirel, S.; Roubinet, D.; Irving, J.

    2014-12-01

    The study of fractured rocks is extremely important in a variety of research fields and applications such as hydrogeology, hydrocarbon extraction and long-term storage of toxic waste. As fractures are highly conductive structures in comparison to the surrounding rock, their presence can be either an advantage or a drawback. For hydrocarbon extraction, fractures allow for quick and easy access to the resource whereas for toxic waste storage their presence increases the risk of leakage and migration of pollutants. In both cases, the identification of fracture network characteristics is an essential step. Recently, we have developed an approach for modeling electric current flow in 2D fractured media. This approach is based on a discrete-dual-porosity model where fractures are represented explicitly, the matrix is coarsely discretized into blocks, and current flow exchange between the fractures and matrix is analytically evaluated at the fracture-scale and integrated at the block-scale [1]. Although this approach has shown much promise and has proven its efficiency for 2D simulations, its extension to 3D remains to be addressed. To this end, we assume that fractures can be represented as two-dimensional finite planes embedded in the surrounding matrix, and we express analytically the distribution of electric potential at the fracture scale. This fracture-scale expression takes into account the electric-current-flow exchange with the surrounding matrix and flow conservation is enforced at the fracture intersections. The fracture-matrix exchange is then integrated at the matrix-block scale where the electric current flow conservation at the block boundaries is formulated with a modified finite volume method. With the objective of providing a low-computational-cost modeling approach adapted to 3D simulations in fractured media, our model is (i) validated and compared to existing modeling approaches and, (ii) used to evaluate the impact of the presence of fractures on

  9. Energy flow in passive and active 3D cochlear model

    NASA Astrophysics Data System (ADS)

    Wang, Yanli; Puria, Sunil; Steele, Charles

    2015-12-01

    Energy flow in the cochlea is an important characteristic of the cochlear traveling wave, and many investigators, such as von Békésy and Lighthill, have discussed this phenomenon. Particularly after the discovery of the motility of the outer hair cells (OHCs), the nature of the power gain of the cochlea has been a fundamental research question. In the present work, direct three-dimensional (3D) calculations of the power on cross sections of the cochlea and on the basilar membrane are performed based on a box model of the mouse cochlea. The distributions of the fluid pressure and fluid velocity in the scala vestibuli are presented. The power output from the OHCs and the power loss due to fluid viscous damping are calculated along the length of the cochlea. This work provides a basis for theoretical calculations of the power gain of the OHCs from mechanical considerations.

  10. Energy flow in passive and active 3D cochlear model

    SciTech Connect

    Wang, Yanli; Steele, Charles; Puria, Sunil

    2015-12-31

    Energy flow in the cochlea is an important characteristic of the cochlear traveling wave, and many investigators, such as von Békésy and Lighthill, have discussed this phenomenon. Particularly after the discovery of the motility of the outer hair cells (OHCs), the nature of the power gain of the cochlea has been a fundamental research question. In the present work, direct three-dimensional (3D) calculations of the power on cross sections of the cochlea and on the basilar membrane are performed based on a box model of the mouse cochlea. The distributions of the fluid pressure and fluid velocity in the scala vestibuli are presented. The power output from the OHCs and the power loss due to fluid viscous damping are calculated along the length of the cochlea. This work provides a basis for theoretical calculations of the power gain of the OHCs from mechanical considerations.

  11. Slat Cove Unsteadiness Effect of 3D Flow Structures

    NASA Technical Reports Server (NTRS)

    Choudhari, Meelan M.; Khorrami, Mehdi R.

    2006-01-01

    Previous studies have indicated that 2D, time accurate computations based on a pseudo-laminar zonal model of the slat cove region (within the framework of the Reynolds-Averaged Navier-Stokes equations) are inadequate for predicting the full unsteady dynamics of the slat cove flow field. Even though such computations could capture the large-scale, unsteady vorticity structures in the slat cove region without requiring any external forcing, the simulated vortices were excessively strong and the recirculation zone was unduly energetic in comparison with the PIV measurements for a generic high-lift configuration. To resolve this discrepancy and to help enable physics based predictions of slat aeroacoustics, the present paper is focused on 3D simulations of the slat cove flow over a computational domain of limited spanwise extent. Maintaining the pseudo-laminar approach, current results indicate that accounting for the three-dimensionality of flow fluctuations leads to considerable improvement in the accuracy of the unsteady, nearfield solution. Analysis of simulation data points to the likely significance of turbulent fluctuations near the reattachment region toward the generation of broadband slat noise. The computed acoustic characteristics (in terms of the frequency spectrum and spatial distribution) within short distances from the slat resemble the previously reported, subscale measurements of slat noise.

  12. Optical Microangiography: A Label Free 3D Imaging Technology to Visualize and Quantify Blood Circulations within Tissue Beds in vivo

    PubMed Central

    Wang, Ruikang K

    2009-01-01

    Optical microangiography (OMAG) is a recently developed volumetric imaging technique that is capable of producing 3D images of dynamic blood perfusion within microcirculatory tissue beds in vivo. The imaging contrast of OMAG image is based on the intrinsic optical scattering signals backscattered by the moving blood cells in patent blood vessels, thus it is a label free imaging technique. In this paper, I will first discuss its recent developments that use a constant modulation frequency introduced in the spectral interferograms to achieve the blood perfusion imaging. I will then introduce its latest development that utilizes the inherent blood flow to modulate the spectral interferograms to realize the blood perfusion imaging. Finally, examples of using OMAG to delineate the dynamic blood perfusion, down to capillary level resolution, within living tissues are given, including cortical blood perfusion in the brain of small animals and blood flow within human retina and choroids. PMID:20657761

  13. Optical Microangiography: A Label Free 3D Imaging Technology to Visualize and Quantify Blood Circulations within Tissue Beds in vivo.

    PubMed

    Wang, Ruikang K

    2010-05-01

    Optical microangiography (OMAG) is a recently developed volumetric imaging technique that is capable of producing 3D images of dynamic blood perfusion within microcirculatory tissue beds in vivo. The imaging contrast of OMAG image is based on the intrinsic optical scattering signals backscattered by the moving blood cells in patent blood vessels, thus it is a label free imaging technique. In this paper, I will first discuss its recent developments that use a constant modulation frequency introduced in the spectral interferograms to achieve the blood perfusion imaging. I will then introduce its latest development that utilizes the inherent blood flow to modulate the spectral interferograms to realize the blood perfusion imaging. Finally, examples of using OMAG to delineate the dynamic blood perfusion, down to capillary level resolution, within living tissues are given, including cortical blood perfusion in the brain of small animals and blood flow within human retina and choroids.

  14. Stabilized finite elements for 3D reactive flows

    NASA Astrophysics Data System (ADS)

    Braack, M.; Richter, Th.

    2006-07-01

    Objective of this work is the numerical solution of chemically reacting flows in three dimensions described by detailed reaction mechanism. The contemplated problems include, e.g. burners with 3D geometry. Contrary to the usual operator splitting method the equations are treated fully coupled with a Newton solver. This leads to the necessity of the solution of large linear non-symmetric, indefinite systems. Due to the complexity of the regarded problems we combine a variety of numerical methods, as there are goal-oriented adaptive mesh refinement, a parallel multigrid solver for the linear systems and economical stabilization techniques for the stiff problems.By blocking the solution components for every ansatz function and applying special matrix structures for each block of degrees of freedom, we can significantly reduce the required memory effort without worsening the convergence. Considering the Galerkin formulation of the regarded problems this is established by using lumping of the mass matrix and the chemical source terms. However, this technique is not longer feasible for standard stabilized finite elements as for instance Galerkin least squares techniques or streamline diffusion. Those stabilized schemes are well established for Navier-Stokes flows but for reactive flows, they introduce many further couplings into the system compared to Galerkin formulations. In this work, we discuss this issue in connection with combustion in more detail and propose the local projection stabilization technique for reactive flows. Beside the robustness of the arising linear systems we are able to maintain the problem-adapted matrix structures presented above. Finally, we will present numerical results for the proposed methods. In particular, we simulate a methane burner with a detailed reaction system involving 15 chemical species and 84 elementary reactions.

  15. ICEd-ALE Treatment of 3-D Fluid Flow.

    1999-09-13

    Version: 00 SALE3D calculates three-dimensional fluid flow at all speeds, from the incompressible limit to highly supersonic. An implicit treatment of the pressure calculation similar to that in the Implicit Continuous-fluid Eulerian (ICE) technique provides this flow speed flexibility. In addition, the computing mesh may move with the fluid in a typical Lagrangian fashion, be held in an Eulerian manner, or move in some arbitrarily specified way to provide a continuous rezoning capability. This latitudemore » results from use of an Arbitrary Lagrangian-Eulerian (ALE) treatment of the mesh. The partial differential equations solved are the Navier-Stokes equations and the mass and internal energy equations. The fluid pressure is determined from an equation of state and supplemented with an artificial viscous pressure for the computation of shock waves. The computing mesh consists of a three-dimensional network of arbitrarily shaped, six-sided deformable cells, and a variety of user-selectable boundary conditions are provided in the program.« less

  16. 3D RECONNECTION AND FLOW DYNAMICS IN THE SSX EXPERIMENT

    SciTech Connect

    Brown, M. R.; Cothran, C. D.; Cohen, D. H.; Horwitz, J.; Chaplin, V.

    2009-07-26

    Several new experimental results are reported from plasma merging studies at the Swarthmore Spheromak Experiment (SSX) with relevance to collisionless three-dimensional magnetic reconnection in laboratory and space plasmas. First, recent high-resolution velocity measurements of impurity ions using ion Doppler spectroscopy (IDS) show bi-directional outflow jets at 40 km/s (nearly the Alfven speed). The SSX IDS instrument measures with 1 mus or better time resolution the width and Doppler shift of the C{sub III} impurity (H plasma) 229.7 nm line to determine the temperature and line-averaged flow velocity during spheromak merging events. High flow speeds are corroborated using an in situ Mach probe. Second, ion heating to nearly 10{sup 6} K is observed after reconnection events in a low-density kinetic regime. Transient electron heating is inferred from bursts on a 4-channel soft x-ray array as well as vacuum ultraviolet spectroscopy. Third, the out-of-plane magnetic field and the in-plane Lorentz force in a reconnection volume both show a quadrupolar structure at the ion inertial scale (c/omega{sub pi}). Time resolved vector magnetic field measurements on a 3D lattice B(r, t)) enables this measurement. Earlier work at SSX has shown that formation of three-dimensional structure at the ion inertial scale is temporally and spatially correlated with the observation of superthermal, super-Alfvenic ions accelerated along the X-line normal to the local 2D plane of reconnection. Each of these measurements will be related to and compared with similar observations in a solar or space context. Keywords: spheromak, flow, heating.

  17. Simultaneous 3D Strain and Flow Fields Measurement of a Model Artery under Unsteady Flows

    NASA Astrophysics Data System (ADS)

    Toloui, Mostafa; Sheng, Jian

    2011-11-01

    Fluid-Structure Interaction imposes challenges in both aero-elasticity and biomedical studies. A simultaneous solid deformation and fluid flow measurement technique based on digital in-line holographic particle tracking velocimetry (PTV) has been developed. It allows us to measure concurrently 3D strain field of a deforming structure and the unsteady flow near it. To facilitate the measurement, both wall and flow are seeded with tracer particles distinguished by size. The motion of these tracers provides the 3D deformation of the wall and the 3D velocity distribution of the flow separately. A fully index matched facility including transparent artery and NaI solution is constructed to enable observations near the wall or through the complex geometry. An arterial model with the inner diameter of 9.5 mm and the thickness of 0.9 mm is manufactured from the cross-linked transparent PDMS at the mixing ratio of 1:10 and doped with mono-dispersed 19 μm polystyrene particles. A cinematic holographic PTV system is used to trace the 3D particle motion in the model and flow simultaneously. Preliminary study is performed within a sample volume of 15 × 15 × 75 mm with the spatial resolution of 7.4 μm in lateral and 10 μm in depth. Uncertainty and accuracy analysis will be reported. NSF Grant No: CBET-0844647.

  18. 3-D Ultrafast Doppler Imaging Applied to the Noninvasive and Quantitative Imaging of Blood Vessels in Vivo

    PubMed Central

    Provost, J.; Papadacci, C.; Demene, C.; Gennisson, J-L.; Tanter, M.; Pernot, M.

    2016-01-01

    Ultrafast Doppler Imaging was introduced as a technique to quantify blood flow in an entire 2-D field of view, expanding the field of application of ultrasound imaging to the highly sensitive anatomical and functional mapping of blood vessels. We have recently developed 3-D Ultrafast Ultrasound Imaging, a technique that can produce thousands of ultrasound volumes per second, based on three-dimensional plane and diverging wave emissions, and demonstrated its clinical feasibility in human subjects in vivo. In this study, we show that non-invasive 3-D Ultrafast Power Doppler, Pulsed Doppler, and Color Doppler Imaging can be used to perform quantitative imaging of blood vessels in humans when using coherent compounding of three-dimensional tilted plane waves. A customized, programmable, 1024-channel ultrasound system was designed to perform 3-D Ultrafast Imaging. Using a 32X32, 3-MHz matrix phased array (Vermon, France), volumes were beamformed by coherently compounding successive tilted plane wave emissions. Doppler processing was then applied in a voxel-wise fashion. 3-D Ultrafast Power Doppler Imaging was first validated by imaging Tygon tubes of varying diameter and its in vivo feasibility was demonstrated by imaging small vessels in the human thyroid. Simultaneous 3-D Color and Pulsed Doppler Imaging using compounded emissions were also applied in the carotid artery and the jugular vein in one healthy volunteer. PMID:26276956

  19. RV functional imaging: 3-D echo-derived dynamic geometry and flow field simulations.

    PubMed

    Pasipoularides, Ares D; Shu, Ming; Womack, Michael S; Shah, Ashish; Von Ramm, Olaf; Glower, Donald D

    2003-01-01

    We describe a novel functional imaging approach for quantitative analysis of right ventricular (RV) blood flow patterns in specific experimental animals (or humans) using real-time, three-dimensional (3-D) echocardiography (RT3D). The method is independent of the digital imaging modality used. It comprises three parts. First, a semiautomated segmentation aided by intraluminal contrast medium locates the RV endocardial surface. Second, a geometric scheme for dynamic RV chamber reconstruction applies a time interpolation procedure to the RT3D data to quantify wall geometry and motion at 400 Hz. A volumetric prism method validated the dynamic geometric reconstruction against simultaneous sonomicrometric canine measurements. Finally, the RV endocardial border motion information is used for mesh generation on a computational fluid dynamics solver to simulate development of the early RV diastolic inflow field. Boundary conditions (tessellated endocardial surface nodal velocities) for the solver are directly derived from the endocardial geometry and motion information. The new functional imaging approach may yield important kinematic information on the distribution of instantaneous velocities in the RV diastolic flow field of specific normal or diseased hearts. PMID:12388220

  20. Effects of Presence, Copresence, and Flow on Learning Outcomes in 3D Learning Spaces

    ERIC Educational Resources Information Center

    Hassell, Martin D.; Goyal, Sandeep; Limayem, Moez; Boughzala, Imed

    2012-01-01

    The level of satisfaction and effectiveness of 3D virtual learning environments were examined. Additionally, 3D virtual learning environments were compared with face-to-face learning environments. Students that experienced higher levels of flow and presence also experienced more satisfaction but not necessarily more effectiveness with 3D virtual…

  1. Recent Enhancements to USM3D Unstructured Flow Solver for Unsteady Flows

    NASA Technical Reports Server (NTRS)

    Pandya, Mohagna J.; Frink, Neal T.; Abdol-Hamid, Khaled S.; Chung, James J.

    2004-01-01

    The NASA USM3D unstructured flow solver is undergoing extensions to address dynamic flow problems in support of NASA and NAVAIR efforts to study the applicability of Computational Fluid Dynamics tools for the prediction of aircraft stability and control characteristics. The initial extensions reported herein include two second-order time stepping schemes, Detached-Eddy Simulation, and grid motion. This paper reports the initial code verification and validation assessment of the dynamic flow capabilities of USM3D. The cases considered are the classic inviscid shock-tube problem, low Reynolds number wake shedding from a NACA 0012 airfoil, high Reynolds number DES-based wake shedding from a 4-to-1 length-to-diameter cylinder, and forced pitch oscillation of a NACA 0012 airfoil with inviscid and turbulent flow.

  2. Modeling 3-D Slope Stability of Coastal Bluffs Using 3-D Ground-Water Flow, Southwestern Seattle, Washington

    USGS Publications Warehouse

    Brien, Dianne L.; Reid, Mark E.

    2007-01-01

    Landslides are a common problem on coastal bluffs throughout the world. Along the coastal bluffs of the Puget Sound in Seattle, Washington, landslides range from small, shallow failures to large, deep-seated landslides. Landslides of all types can pose hazards to human lives and property, but deep-seated landslides are of significant concern because their large areal extent can cause extensive property damage. Although many geomorphic processes shape the coastal bluffs of Seattle, we focus on large (greater than 3,000 m3), deepseated, rotational landslides that occur on the steep bluffs along Puget Sound. Many of these larger failures occur in advance outwash deposits of the Vashon Drift (Qva); some failures extend into the underlying Lawton Clay Member of the Vashon Drift (Qvlc). The slope stability of coastal bluffs is controlled by the interplay of three-dimensional (3-D) variations in gravitational stress, strength, and pore-water pressure. We assess 3-D slope-stability using SCOOPS (Reid and others, 2000), a computer program that allows us to search a high-resolution digital-elevation model (DEM) to quantify the relative stability of all parts of the landscape by computing the stability and volume of thousands of potential spherical failures. SCOOPS incorporates topography, 3-D strength variations, and 3-D pore pressures. Initially, we use our 3-D analysis methods to examine the effects of topography and geology by using heterogeneous material properties, as defined by stratigraphy, without pore pressures. In this scenario, the least-stable areas are located on the steepest slopes, commonly in Qva or Qvlc. However, these locations do not agree well with observations of deep-seated landslides. Historically, both shallow colluvial landslides and deep-seated landslides have been observed near the contact between Qva and Qvlc, and commonly occur in Qva. The low hydraulic conductivity of Qvlc impedes ground-water flow, resulting in elevated pore pressures at the

  3. Label-free characterization of white blood cells by measuring 3D refractive index maps

    PubMed Central

    Yoon, Jonghee; Kim, Kyoohyun; Park, HyunJoo; Choi, Chulhee; Jang, Seongsoo; Park, YongKeun

    2015-01-01

    The characterization of white blood cells (WBCs) is crucial for blood analyses and disease diagnoses. However, current standard techniques rely on cell labeling, a process which imposes significant limitations. Here we present three-dimensional (3D) optical measurements and the label-free characterization of mouse WBCs using optical diffraction tomography. 3D refractive index (RI) tomograms of individual WBCs are constructed from multiple two-dimensional quantitative phase images of samples illuminated at various angles of incidence. Measurements of the 3D RI tomogram of WBCs enable the separation of heterogeneous populations of WBCs using quantitative morphological and biochemical information. Time-lapse tomographic measurements also provide the 3D trajectory of micrometer-sized beads ingested by WBCs. These results demonstrate that optical diffraction tomography can be a useful and versatile tool for the study of WBCs. PMID:26504637

  4. 3D topographic correction of the BSR heat flow and detection of focused fluid flow

    NASA Astrophysics Data System (ADS)

    He, Tao; Li, Hong-Lin; Zou, Chang-Chun

    2014-06-01

    The bottom-simulating reflector (BSR) is a seismic indicator of the bottom of a gas hydrate stability zone. Its depth can be used to calculate the seafloor surface heat flow. The calculated BSR heat flow variations include disturbances from two important factors: (1) seafloor topography, which focuses the heat flow over regions of concave topography and defocuses it over regions of convex topography, and (2) the focused warm fluid flow within the accretionary prism coming from depths deeper than BSR. The focused fluid flow can be detected if the contribution of the topography to the BSR heat flow is removed. However, the analytical equation cannot solve the topographic effect at complex seafloor regions. We prove that 3D finite element method can model the topographic effect on the regional background heat flow with high accuracy, which can then be used to correct the topographic effect and obtain the BSR heat flow under the condition of perfectly flat topography. By comparing the corrected BSR heat flow with the regional background heat flow, focused fluid flow regions can be detected that are originally too small and cannot be detected using present-day equipment. This method was successfully applied to the midslope region of northern Cascadia subducting margin. The results suggest that the Cucumber Ridge and its neighboring area are positive heat flow anomalies, about 10%-20% higher than the background heat flow after 3D topographic correction. Moreover, the seismic imaging associated the positive heat flow anomaly areas with seabed fracture-cavity systems. This suggests flow of warm gas-carrying fluids along these high-permeability pathways, which could result in higher gas hydrate concentrations.

  5. Implementation of Flow Tripping Capability in the USM3D Unstructured Flow Solver

    NASA Technical Reports Server (NTRS)

    Pandya, Mohagna J.; Abdol-Harrid, Khaled S.; Campbell, Richard L.; Frink, Neal T.

    2006-01-01

    A flow tripping capability is added to an established NASA tetrahedral unstructured parallel Navier-Stokes flow solver, USM3D. The capability is based on prescribing an appropriate profile of turbulence model variables to energize the boundary layer in a plane normal to a specified trip region on the body surface. We demonstrate this approach using the k-e two-equation turbulence model of USM3D. Modification to the solution procedure primarily consists of developing a data structure to identify all unstructured tetrahedral grid cells located in the plane normal to a specified surface trip region and computing a function based on the mean flow solution to specify the modified profile of the turbulence model variables. We leverage this data structure and also show an adjunct approach that is based on enforcing a laminar flow condition on the otherwise fully turbulent flow solution in user specified region. The latter approach is applied for the solutions obtained using other one- and two-equation turbulence models of USM3D. A key ingredient of the present capability is the use of a graphical user-interface tool PREDISC to define a trip region on the body surface in an existing grid. Verification of the present modifications is demonstrated on three cases, namely, a flat plate, the RAE2822 airfoil, and the DLR F6 wing-fuselage configuration.

  6. Implementation of Flow Tripping Capability in the USM3D Unstructured Flow Solver

    NASA Technical Reports Server (NTRS)

    Pandya, Mohagna J.; Abdol-Hamid, Khaled S.; Campbell, Richard L.; Frink, Neal T.

    2006-01-01

    A flow tripping capability is added to an established NASA tetrahedral unstructured parallel Navier-Stokes flow solver, USM3D. The capability is based on prescribing an appropriate profile of turbulence model variables to energize the boundary layer in a plane normal to a specified trip region on the body surface. We demonstrate this approach using the k-epsilon two-equation turbulence model of USM3D. Modification to the solution procedure primarily consists of developing a data structure to identify all unstructured tetrahedral grid cells located in the plane normal to a specified surface trip region and computing a function based on the mean flow solution to specify the modified profile of the turbulence model variables. We leverage this data structure and also show an adjunct approach that is based on enforcing a laminar flow condition on the otherwise fully turbulent flow solution in user-specified region. The latter approach is applied for the solutions obtained using other one-and two-equation turbulence models of USM3D. A key ingredient of the present capability is the use of a graphical user-interface tool PREDISC to define a trip region on the body surface in an existing grid. Verification of the present modifications is demonstrated on three cases, namely, a flat plate, the RAE2822 airfoil, and the DLR F6 wing-fuselage configuration.

  7. Blood Flow in Arteries

    NASA Astrophysics Data System (ADS)

    Ku, David N.

    Blood flow in arteries is dominated by unsteady flow phenomena. The cardiovascular system is an internal flow loop with multiple branches in which a complex liquid circulates. A nondimensional frequency parameter, the Womersley number, governs the relationship between the unsteady and viscous forces. Normal arterial flow is laminar with secondary flows generated at curves and branches. The arteries are living organs that can adapt to and change with the varying hemodynamic conditions. In certain circumstances, unusual hemodynamic conditions create an abnormal biological response. Velocity profile skewing can create pockets in which the direction of the wall shear stress oscillates. Atherosclerotic disease tends to be localized in these sites and results in a narrowing of the artery lumena stenosis. The stenosis can cause turbulence and reduce flow by means of viscous head losses and flow choking. Very high shear stresses near the throat of the stenosis can activate platelets and thereby induce thrombosis, which can totally block blood flow to the heart or brain. Detection and quantification of stenosis serve as the basis for surgical intervention. In the future, the study of arterial blood flow will lead to the prediction of individual hemodynamic flows in any patient, the development of diagnostic tools to quantify disease, and the design of devices that mimic or alter blood flow. This field is rich with challenging problems in fluid mechanics involving three-dimensional, pulsatile flows at the edge of turbulence.

  8. SSME 3-D Turnaround Duct flow analysis - CFD predictions

    NASA Technical Reports Server (NTRS)

    Brankovic, Andreja; Stowers, Steven T.; Mcconnaughey, Paul

    1988-01-01

    CFD analysis is presently employed to obtain an improved flowfield for an individual flowpath in the case of the Space Shuttle Main Engine's High Pressure Fuel Turbopump Turn-Around Duct (TAD), which conducts the flow exiting from the gas turbines into the fuel bowl. It is demonstrated that the application of CFD to TAD flow analysis, giving attention to the duct's configuration and to the number, shape, and alignment of the diffuser struts, can enhance understanding of flow physics and result in improved duct design and performance.

  9. Gas flow environmental and heat transfer nonrotating 3D program

    NASA Technical Reports Server (NTRS)

    Geil, T.; Steinhoff, J.

    1983-01-01

    A complete set of benchmark quality data for the flow and heat transfer within a large rectangular turning duct is being compiled. These data will be used to evaluate and verify three dimensional internal viscous flow models and computational codes. The analytical objective is to select such a computational code and define the capabilities of this code to predict the experimental results. Details of the proper code operation will be defined and improvements to the code modeling capabilities will be formulated.

  10. Segmented Domain Decomposition Multigrid For 3-D Turbomachinery Flows

    NASA Technical Reports Server (NTRS)

    Celestina, M. L.; Adamczyk, J. J.; Rubin, S. G.

    2001-01-01

    A Segmented Domain Decomposition Multigrid (SDDMG) procedure was developed for three-dimensional viscous flow problems as they apply to turbomachinery flows. The procedure divides the computational domain into a coarse mesh comprised of uniformly spaced cells. To resolve smaller length scales such as the viscous layer near a surface, segments of the coarse mesh are subdivided into a finer mesh. This is repeated until adequate resolution of the smallest relevant length scale is obtained. Multigrid is used to communicate information between the different grid levels. To test the procedure, simulation results will be presented for a compressor and turbine cascade. These simulations are intended to show the ability of the present method to generate grid independent solutions. Comparisons with data will also be presented. These comparisons will further demonstrate the usefulness of the present work for they allow an estimate of the accuracy of the flow modeling equations independent of error attributed to numerical discretization.

  11. Gas flow environmental and heat transfer nonrotating 3D program

    NASA Technical Reports Server (NTRS)

    Crawford, R. A.

    1984-01-01

    The experimental contract objective is to provide a complete set of benchmark quality data for the flow within a large rectangular turning duct. The data are to be used to evaluate and verify three-dimensional internal viscous flow models and computational codes. The analytical contract objective is to select such a computational code and define the capabilities of this code to predict the experimental results. Details of the proper code operation will be defined and improvements to the code modeling capabilities will be formulated.

  12. Mechanics of blood flow.

    PubMed

    Skalak, R; Keller, S R; Secomb, T W

    1981-05-01

    The historical development of the mechanics of blood flow can be traced from ancient times, to Leonardo da Vinci and Leonhard Euler and up to the present times with increasing biological knowledge and mathematical analysis. In the last two decades, quantitative and numerical methods have steadily given more complete and precise understanding. In the arterial system wave propagation computations based on nonlinear one-dimensional modeling have given the best representation of pulse wave propagation. In the veins, the theory of unsteady flow in collapsible tubes has recently been extensively developed. In the last decade, progress has been made in describing the blood flow at junctions, through stenoses, in bends and in capillary blood vessels. The rheological behavior of individual red blood cells has been explored. A working model consists of an elastic membrane filled with viscous fluid. This model forms a basis for understanding the viscous and viscoelastic behavior of blood. PMID:7024641

  13. Laser direct writing 3D structures for microfluidic channels: flow meter and mixer

    NASA Astrophysics Data System (ADS)

    Lin, Chih-Lang; Liu, Yi-Jui; Lin, Zheng-Da; Wu, Bo-Long; Lee, Yi-Hsiung; Shin, Chow-Shing; Baldeck, Patrice L.

    2015-03-01

    The 3D laser direct-writing technology is aimed at the modeling of arbitrary three-dimensional (3D) complex microstructures by scanning a laser-focusing point along predetermined trajectories. Through the perspective technique, the details of designed 3D structures can be properly fabricated in a microchannel. This study introduces a direct reading flow meter and a 3D passive mixer fabricated by laser direct writing for microfluidic applications. The flow meter consists of two rod-shaped springs, a pillar, an anchor, and a wedge-shaped indicator, installed inside a microfluidic channel. The indicator is deflected by the flowing fluid while restrained by the spring to establish an equilibrium indication according to the flow rate. The measurement is readily carried out by optical microscopy observation. The 3D passive Archimedes-screw-shaped mixer is designed to disturb the laminar flow 3D direction for enhancing the mixing efficiency. The simulation results indicate that the screw provides 3D disturbance of streamlines in the microchannel. The mixing demonstration for fluids flowing in the micrchannel approximately agrees with the simulation result. Thanks to the advantage of the laser direct writing technology, this study performs the ingenious applications of 3D structures for microchannels.

  14. Engineering an in vitro air-blood barrier by 3D bioprinting

    PubMed Central

    Horváth, Lenke; Umehara, Yuki; Jud, Corinne; Blank, Fabian; Petri-Fink, Alke; Rothen-Rutishauser, Barbara

    2015-01-01

    Intensive efforts in recent years to develop and commercialize in vitro alternatives in the field of risk assessment have yielded new promising two- and three dimensional (3D) cell culture models. Nevertheless, a realistic 3D in vitro alveolar model is not available yet. Here we report on the biofabrication of the human air-blood tissue barrier analogue composed of an endothelial cell, basement membrane and epithelial cell layer by using a bioprinting technology. In contrary to the manual method, we demonstrate that this technique enables automatized and reproducible creation of thinner and more homogeneous cell layers, which is required for an optimal air-blood tissue barrier. This bioprinting platform will offer an excellent tool to engineer an advanced 3D lung model for high-throughput screening for safety assessment and drug efficacy testing. PMID:25609567

  15. Lattice Boltzmann Model of 3D Multiphase Flow in Artery Bifurcation Aneurysm Problem.

    PubMed

    Abas, Aizat; Mokhtar, N Hafizah; Ishak, M H H; Abdullah, M Z; Ho Tian, Ang

    2016-01-01

    This paper simulates and predicts the laminar flow inside the 3D aneurysm geometry, since the hemodynamic situation in the blood vessels is difficult to determine and visualize using standard imaging techniques, for example, magnetic resonance imaging (MRI). Three different types of Lattice Boltzmann (LB) models are computed, namely, single relaxation time (SRT), multiple relaxation time (MRT), and regularized BGK models. The results obtained using these different versions of the LB-based code will then be validated with ANSYS FLUENT, a commercially available finite volume- (FV-) based CFD solver. The simulated flow profiles that include velocity, pressure, and wall shear stress (WSS) are then compared between the two solvers. The predicted outcomes show that all the LB models are comparable and in good agreement with the FVM solver for complex blood flow simulation. The findings also show minor differences in their WSS profiles. The performance of the parallel implementation for each solver is also included and discussed in this paper. In terms of parallelization, it was shown that LBM-based code performed better in terms of the computation time required. PMID:27239221

  16. Lattice Boltzmann Model of 3D Multiphase Flow in Artery Bifurcation Aneurysm Problem

    PubMed Central

    Abas, Aizat; Mokhtar, N. Hafizah; Ishak, M. H. H.; Abdullah, M. Z.; Ho Tian, Ang

    2016-01-01

    This paper simulates and predicts the laminar flow inside the 3D aneurysm geometry, since the hemodynamic situation in the blood vessels is difficult to determine and visualize using standard imaging techniques, for example, magnetic resonance imaging (MRI). Three different types of Lattice Boltzmann (LB) models are computed, namely, single relaxation time (SRT), multiple relaxation time (MRT), and regularized BGK models. The results obtained using these different versions of the LB-based code will then be validated with ANSYS FLUENT, a commercially available finite volume- (FV-) based CFD solver. The simulated flow profiles that include velocity, pressure, and wall shear stress (WSS) are then compared between the two solvers. The predicted outcomes show that all the LB models are comparable and in good agreement with the FVM solver for complex blood flow simulation. The findings also show minor differences in their WSS profiles. The performance of the parallel implementation for each solver is also included and discussed in this paper. In terms of parallelization, it was shown that LBM-based code performed better in terms of the computation time required. PMID:27239221

  17. 3D automatic Cartesian grid generation for Euler flows

    NASA Technical Reports Server (NTRS)

    Melton, John E.; Enomoto, Francis Y.; Berger, Marsha J.

    1993-01-01

    We describe a Cartesian grid strategy for the study of three dimensional inviscid flows about arbitrary geometries that uses both conventional and CAD/CAM surface geometry databases. Initial applications of the technique are presented. The elimination of the body-fitted constraint allows the grid generation process to be automated, significantly reducing the time and effort required to develop suitable computational grids for inviscid flowfield simulations.

  18. Vorticity Generation on a Flat Surface in 3D Flows

    NASA Astrophysics Data System (ADS)

    Casciola, C. M.; Piva, R.; Bassanini, P.

    1996-12-01

    Vortex methods, based on the splitting into Euler and Stokes operators, have been successfully adopted in numerical solutions of three-dimensional Navier-Stokes equations in free-space. Here we deal with their application to flows bounded by solid walls, discussing in particular the boundary conditions for vorticity and their approximation. In two dimensions this has been accomplished by introducing a vortex sheet at the wall, determined by the local slip-velocity, as an approximation of the vorticity source. For three-dimensional flows, we analyze in the context of the Stokes substep the integral equation for the vorticity source and its connection with the creation algorithm adopted in vortex methods. The present analysis leads to a formulation which shows the connection between the exact vorticity source at the wall and the discrete vorticity creation operator adopted in the Chorin-Marsden formula. In particular, the slip velocity at the wall is identified as an approximate solution of the integral equation for the vorticity source and the corresponding error estimate is also discussed. Besides showing the consistency of this approximation, we indicate a numerical procedure which provides a wall-generation of solenoidal vorticity. This is a crucial issue for an accurate application of vortex methods to three-dimensional flows.

  19. Evolution of 3-D geologic framework modeling and its application to groundwater flow studies

    USGS Publications Warehouse

    Blome, Charles D.; Smith, David V.

    2012-01-01

    In this Fact Sheet, the authors discuss the evolution of project 3-D subsurface framework modeling, research in hydrostratigraphy and airborne geophysics, and methodologies used to link geologic and groundwater flow models.

  20. 3D-Flow processor for a programmable Level-1 trigger (feasibility study)

    SciTech Connect

    Crosetto, D.

    1992-10-01

    A feasibility study has been made to use the 3D-Flow processor in a pipelined programmable parallel processing architecture to identify particles such as electrons, jets, muons, etc., in high-energy physics experiments.

  1. Axisymmetric and 3D calculations of melt flow during VCz growth

    NASA Astrophysics Data System (ADS)

    Bänsch, E.; Davis, D.; Langmach, H.; Miller, W.; Rehse, U.; Reinhardt, G.; Uhle, M.

    2004-05-01

    Axisymmetric and 3D calculations of melt flow have been performed for a configuration used at the vapour-pressure-controlled Czochalski growth of GaAs single crystals. Thermal boundary conditions were adapted from a global simulation of the temperature field. The axisymmetric calculations with the code NAVIER confirmed the ones previously perfomed with FIDAP TM. The 3D calculations showed that the flow exhibits an asymmetric transient behaviour beyond a certain critical Reynolds number.

  2. Tissue blood flow mapping

    NASA Astrophysics Data System (ADS)

    Nilsson, G. E.

    1997-01-01

    The operating principles of Laser Doppler Perfusion Imaging (LDPI) for visualization of the tissue blood perfusion are explained. Using this emerging technology skin perfusion has been investigated in healthy volunteers and in patients with various conditions that affect skin blood flow. LDPI is anticipated to be particularly useful in evaluation of peripheral circulation in diabetics, as an objective tool in irritancy patch testing, assessment of burnt skin and visualization of spot-wise hyperperfusion in breast skin in association with carcinoma.

  3. Extended 3D Approach for Quantification of Abnormal Ascending Aortic Flow

    PubMed Central

    Sigovan, Monica; Dyverfeldt, Petter; Wrenn, Jarrett; Tseng, Elaine E.; Saloner, David; Hope, Michael D.

    2015-01-01

    Background Flow displacement quantifies eccentric flow, a potential risk factor for aneurysms in the ascending aorta, but only at a single anatomic location. The aim of this study is to extend flow displacement analysis to 3D in patients with aortic and aortic valve pathologies. Methods 43 individuals were studied with 4DFlow MRI in 6 groups: healthy, tricuspid aortic valve (TAV) with aortic stenosis (AS) but no dilatation, TAV with dilatation but no AS, and TAV with both AS and dilatation, BAV without AS or dilatation, BAV without AS but with dilation. The protocol was approved by our institutional review board, and informed consent was obtained. Flow displacement was calculated for multiple planes along the ascending aorta, and 2D and 3D analyses were compared. Results Good correlation was found between 2D flow displacement and both maximum and average 3D values (r>0.8). Healthy controls had significantly lower flow displacement values with all approaches (p<0.05). The highest flow displacement was seen with stenotic TAV and aortic dilation (0.24±0.02 with maximum flow displacement). The 2D approach underestimated the maximum flow displacement by more than 20% in 13 out of 36 patients (36%). Conclusions The extended 3D flow displacement analysis offers a more comprehensive quantitative evaluation of abnormal systolic flow in the ascending aorta than 2D analysis. Differences between patient subgroups are better demonstrated, and maximum flow displacement is more reliable assessed. PMID:25721998

  4. A package for 3-D unstructured grid generation, finite-element flow solution and flow field visualization

    NASA Technical Reports Server (NTRS)

    Parikh, Paresh; Pirzadeh, Shahyar; Loehner, Rainald

    1990-01-01

    A set of computer programs for 3-D unstructured grid generation, fluid flow calculations, and flow field visualization was developed. The grid generation program, called VGRID3D, generates grids over complex configurations using the advancing front method. In this method, the point and element generation is accomplished simultaneously, VPLOT3D is an interactive, menudriven pre- and post-processor graphics program for interpolation and display of unstructured grid data. The flow solver, VFLOW3D, is an Euler equation solver based on an explicit, two-step, Taylor-Galerkin algorithm which uses the Flux Corrected Transport (FCT) concept for a wriggle-free solution. Using these programs, increasingly complex 3-D configurations of interest to aerospace community were gridded including a complete Space Transportation System comprised of the space-shuttle orbitor, the solid-rocket boosters, and the external tank. Flow solutions were obtained on various configurations in subsonic, transonic, and supersonic flow regimes.

  5. Validation of a 3D computational fluid-structure interaction model simulating flow through an elastic aperture

    PubMed Central

    Quaini, A.; Canic, S.; Glowinski, R.; Igo, S.; Hartley, C.J.; Zoghbi, W.; Little, S.

    2011-01-01

    This work presents a validation of a fluid-structure interaction computational model simulating the flow conditions in an in vitro mock heart chamber modeling mitral valve regurgitation during the ejection phase during which the trans-valvular pressure drop and valve displacement are not as large. The mock heart chamber was developed to study the use of 2D and 3D color Doppler techniques in imaging the clinically relevant complex intra-cardiac flow events associated with mitral regurgitation. Computational models are expected to play an important role in supporting, refining, and reinforcing the emerging 3D echocardiographic applications. We have developed a 3D computational fluid-structure interaction algorithm based on a semi-implicit, monolithic method, combined with an arbitrary Lagrangian-Eulerian approach to capture the fluid domain motion. The mock regurgitant mitral valve corresponding to an elastic plate with a geometric orifice, was modeled using 3D elasticity, while the blood flow was modeled using the 3D Navier-Stokes equations for an incompressible, viscous fluid. The two are coupled via the kinematic and dynamic conditions describing the two-way coupling. The pressure, the flow rate, and orifice plate displacement were measured and compared with numerical simulation results. In-line flow meter was used to measure the flow, pressure transducers were used to measure the pressure, and a Doppler method developed by one of the authors was used to measure the axial displacement of the orifice plate. The maximum recorded difference between experiment and numerical simulation for the flow rate was 4%, the pressure 3.6%, and for the orifice displacement 15%, showing excellent agreement between the two. PMID:22138194

  6. Determining 3D flow fields via multi-camera light field imaging.

    PubMed

    Truscott, Tadd T; Belden, Jesse; Nielson, Joseph R; Daily, David J; Thomson, Scott L

    2013-03-06

    In the field of fluid mechanics, the resolution of computational schemes has outpaced experimental methods and widened the gap between predicted and observed phenomena in fluid flows. Thus, a need exists for an accessible method capable of resolving three-dimensional (3D) data sets for a range of problems. We present a novel technique for performing quantitative 3D imaging of many types of flow fields. The 3D technique enables investigation of complicated velocity fields and bubbly flows. Measurements of these types present a variety of challenges to the instrument. For instance, optically dense bubbly multiphase flows cannot be readily imaged by traditional, non-invasive flow measurement techniques due to the bubbles occluding optical access to the interior regions of the volume of interest. By using Light Field Imaging we are able to reparameterize images captured by an array of cameras to reconstruct a 3D volumetric map for every time instance, despite partial occlusions in the volume. The technique makes use of an algorithm known as synthetic aperture (SA) refocusing, whereby a 3D focal stack is generated by combining images from several cameras post-capture (1). Light Field Imaging allows for the capture of angular as well as spatial information about the light rays, and hence enables 3D scene reconstruction. Quantitative information can then be extracted from the 3D reconstructions using a variety of processing algorithms. In particular, we have developed measurement methods based on Light Field Imaging for performing 3D particle image velocimetry (PIV), extracting bubbles in a 3D field and tracking the boundary of a flickering flame. We present the fundamentals of the Light Field Imaging methodology in the context of our setup for performing 3DPIV of the airflow passing over a set of synthetic vocal folds, and show representative results from application of the technique to a bubble-entraining plunging jet.

  7. Determining 3D Flow Fields via Multi-camera Light Field Imaging

    PubMed Central

    Truscott, Tadd T.; Belden, Jesse; Nielson, Joseph R.; Daily, David J.; Thomson, Scott L.

    2013-01-01

    In the field of fluid mechanics, the resolution of computational schemes has outpaced experimental methods and widened the gap between predicted and observed phenomena in fluid flows. Thus, a need exists for an accessible method capable of resolving three-dimensional (3D) data sets for a range of problems. We present a novel technique for performing quantitative 3D imaging of many types of flow fields. The 3D technique enables investigation of complicated velocity fields and bubbly flows. Measurements of these types present a variety of challenges to the instrument. For instance, optically dense bubbly multiphase flows cannot be readily imaged by traditional, non-invasive flow measurement techniques due to the bubbles occluding optical access to the interior regions of the volume of interest. By using Light Field Imaging we are able to reparameterize images captured by an array of cameras to reconstruct a 3D volumetric map for every time instance, despite partial occlusions in the volume. The technique makes use of an algorithm known as synthetic aperture (SA) refocusing, whereby a 3D focal stack is generated by combining images from several cameras post-capture 1. Light Field Imaging allows for the capture of angular as well as spatial information about the light rays, and hence enables 3D scene reconstruction. Quantitative information can then be extracted from the 3D reconstructions using a variety of processing algorithms. In particular, we have developed measurement methods based on Light Field Imaging for performing 3D particle image velocimetry (PIV), extracting bubbles in a 3D field and tracking the boundary of a flickering flame. We present the fundamentals of the Light Field Imaging methodology in the context of our setup for performing 3DPIV of the airflow passing over a set of synthetic vocal folds, and show representative results from application of the technique to a bubble-entraining plunging jet. PMID:23486112

  8. ODTLES : a model for 3D turbulent flow based on one-dimensional turbulence modeling concepts.

    SciTech Connect

    McDermott, Randy; Kerstein, Alan R.; Schmidt, Rodney Cannon

    2005-01-01

    This report describes an approach for extending the one-dimensional turbulence (ODT) model of Kerstein [6] to treat turbulent flow in three-dimensional (3D) domains. This model, here called ODTLES, can also be viewed as a new LES model. In ODTLES, 3D aspects of the flow are captured by embedding three, mutually orthogonal, one-dimensional ODT domain arrays within a coarser 3D mesh. The ODTLES model is obtained by developing a consistent approach for dynamically coupling the different ODT line sets to each other and to the large scale processes that are resolved on the 3D mesh. The model is implemented computationally and its performance is tested and evaluated by performing simulations of decaying isotropic turbulence, a standard turbulent flow benchmarking problem.

  9. Strategies for Effectively Visualizing a 3D Flow Using Volume Line Integral Convolution

    NASA Technical Reports Server (NTRS)

    Interrante, Victoria; Grosch, Chester

    1997-01-01

    This paper discusses strategies for effectively portraying 3D flow using volume line integral convolution. Issues include defining an appropriate input texture, clarifying the distinct identities and relative depths of the advected texture elements, and selectively highlighting regions of interest in both the input and output volumes. Apart from offering insights into the greater potential of 3D LIC as a method for effectively representing flow in a volume, a principal contribution of this work is the suggestion of a technique for generating and rendering 3D visibility-impeding 'halos' that can help to intuitively indicate the presence of depth discontinuities between contiguous elements in a projection and thereby clarify the 3D spatial organization of elements in the flow. The proposed techniques are applied to the visualization of a hot, supersonic, laminar jet exiting into a colder, subsonic coflow.

  10. Reacting Multi-Species Gas Capability for USM3D Flow Solver

    NASA Technical Reports Server (NTRS)

    Frink, Neal T.; Schuster, David M.

    2012-01-01

    The USM3D Navier-Stokes flow solver contributed heavily to the NASA Constellation Project (CxP) as a highly productive computational tool for generating the aerodynamic databases for the Ares I and V launch vehicles and Orion launch abort vehicle (LAV). USM3D is currently limited to ideal-gas flows, which are not adequate for modeling the chemistry or temperature effects of hot-gas jet flows. This task was initiated to create an efficient implementation of multi-species gas and equilibrium chemistry into the USM3D code to improve its predictive capabilities for hot jet impingement effects. The goal of this NASA Engineering and Safety Center (NESC) assessment was to implement and validate a simulation capability to handle real-gas effects in the USM3D code. This document contains the outcome of the NESC assessment.

  11. Correlation-based discrimination between cardiac tissue and blood for segmentation of 3D echocardiographic images

    NASA Astrophysics Data System (ADS)

    Saris, Anne E. C. M.; Nillesen, Maartje M.; Lopata, Richard G. P.; de Korte, Chris L.

    2013-03-01

    Automated segmentation of 3D echocardiographic images in patients with congenital heart disease is challenging, because the boundary between blood and cardiac tissue is poorly defined in some regions. Cardiologists mentally incorporate movement of the heart, using temporal coherence of structures to resolve ambiguities. Therefore, we investigated the merit of temporal cross-correlation for automated segmentation over the entire cardiac cycle. Optimal settings for maximum cross-correlation (MCC) calculation, based on a 3D cross-correlation based displacement estimation algorithm, were determined to obtain the best contrast between blood and myocardial tissue over the entire cardiac cycle. Resulting envelope-based as well as RF-based MCC values were used as additional external force in a deformable model approach, to segment the left-ventricular cavity in entire systolic phase. MCC values were tested against, and combined with, adaptive filtered, demodulated RF-data. Segmentation results were compared with manually segmented volumes using a 3D Dice Similarity Index (3DSI). Results in 3D pediatric echocardiographic images sequences (n = 4) demonstrate that incorporation of temporal information improves segmentation. The use of MCC values, either alone or in combination with adaptive filtered, demodulated RF-data, resulted in an increase of the 3DSI in 75% of the cases (average 3DSI increase: 0.71 to 0.82). Results might be further improved by optimizing MCC-contrast locally, in regions with low blood-tissue contrast. Reducing underestimation of the endocardial volume due to MCC processing scheme (choice of window size) and consequential border-misalignment, could also lead to more accurate segmentations. Furthermore, increasing the frame rate will also increase MCC-contrast and thus improve segmentation.

  12. Correlations of Surface Deformation and 3D Flow Field in a Compliant Wall Turbulent Channel Flow.

    NASA Astrophysics Data System (ADS)

    Wang, Jin; Zhang, Cao; Katz, Joseph

    2015-11-01

    This study focuses on the correlations between surface deformation and flow features, including velocity, vorticity and pressure, in a turbulent channel flow over a flat, compliant Polydimethylsiloxane (PDMS) wall. The channel centerline velocity is 2.5 m/s, and the friction Reynolds number is 2.3x103. Analysis is based on simultaneous measurements of the time resolved 3D velocity and surface deformation using tomographic PIV and Mach-Zehnder Interferometry. The volumetric pressure distribution is calculated plane by plane by spatially integrating the material acceleration using virtual boundary, omni-directional method. Conditional sampling based on local high/low pressure and deformation events reveals the primary flow structures causing the deformation. High pressure peaks appear at the interface between sweep and ejection, whereas the negative deformations peaks (dent) appear upstream, under the sweeps. The persistent phase lag between flow and deformations are presumably caused by internal damping within the PDMS. Some of the low pressure peaks and strong ejections are located under the head of hairpin vortices, and accordingly, are associated with positive deformation (bump). Others bumps and dents are correlated with some spanwise offset large inclined quasi-streamwise vortices that are not necessarily associated with hairpins. Sponsored by ONR.

  13. 3D-printed devices for continuous-flow organic chemistry

    PubMed Central

    Dragone, Vincenza; Sans, Victor; Rosnes, Mali H; Kitson, Philip J

    2013-01-01

    Summary We present a study in which the versatility of 3D-printing is combined with the processing advantages of flow chemistry for the synthesis of organic compounds. Robust and inexpensive 3D-printed reactionware devices are easily connected using standard fittings resulting in complex, custom-made flow systems, including multiple reactors in a series with in-line, real-time analysis using an ATR-IR flow cell. As a proof of concept, we utilized two types of organic reactions, imine syntheses and imine reductions, to show how different reactor configurations and substrates give different products. PMID:23766811

  14. Adaptive 3D single-block grids for the computation of viscous flows around wings

    SciTech Connect

    Hagmeijer, R.; Kok, J.C.

    1996-12-31

    A robust algorithm for the adaption of a 3D single-block structured grid suitable for the computation of viscous flows around a wing is presented and demonstrated by application to the ONERA M6 wing. The effects of grid adaption on the flow solution and accuracy improvements is analyzed. Reynolds number variations are studied.

  15. The performance & flow visualization studies of three-dimensional (3-D) wind turbine blade models

    NASA Astrophysics Data System (ADS)

    Sutrisno, Prajitno, Purnomo, W., Setyawan B.

    2016-06-01

    Recently, studies on the design of 3-D wind turbine blades have a less attention even though 3-D blade products are widely sold. In contrary, advanced studies in 3-D helicopter blade tip have been studied rigorously. Studies in wind turbine blade modeling are mostly assumed that blade spanwise sections behave as independent two-dimensional airfoils, implying that there is no exchange of momentum in the spanwise direction. Moreover, flow visualization experiments are infrequently conducted. Therefore, a modeling study of wind turbine blade with visualization experiment is needed to be improved to obtain a better understanding. The purpose of this study is to investigate the performance of 3-D wind turbine blade models with backward-forward swept and verify the flow patterns using flow visualization. In this research, the blade models are constructed based on the twist and chord distributions following Schmitz's formula. Forward and backward swept are added to the rotating blades. Based on this, the additional swept would enhance or diminish outward flow disturbance or stall development propagation on the spanwise blade surfaces to give better blade design. Some combinations, i. e., b lades with backward swept, provide a better 3-D favorable rotational force of the rotor system. The performance of the 3-D wind turbine system model is measured by a torque meter, employing Prony's braking system. Furthermore, the 3-D flow patterns around the rotating blade models are investigated by applying "tuft-visualization technique", to study the appearance of laminar, separated, and boundary layer flow patterns surrounding the 3-dimentional blade system.

  16. Improving segmentation of 3D touching cell nuclei using flow tracking on surface meshes.

    PubMed

    Li, Gang; Guo, Lei

    2012-01-01

    Automatic segmentation of touching cell nuclei in 3D microscopy images is of great importance in bioimage informatics and computational biology. This paper presents a novel method for improving 3D touching cell nuclei segmentation. Given binary touching nuclei by the method in Li et al. (2007), our method herein consists of several steps: surface mesh reconstruction and curvature information estimation; direction field diffusion on surface meshes; flow tracking on surface meshes; and projection of surface mesh segmentation to volumetric images. The method is validated on both synthesised and real 3D touching cell nuclei images, demonstrating its validity and effectiveness.

  17. Development of discrete gas kinetic scheme for simulation of 3D viscous incompressible and compressible flows

    NASA Astrophysics Data System (ADS)

    Yang, L. M.; Shu, C.; Wang, Y.; Sun, Y.

    2016-08-01

    The sphere function-based gas kinetic scheme (GKS), which was presented by Shu and his coworkers [23] for simulation of inviscid compressible flows, is extended to simulate 3D viscous incompressible and compressible flows in this work. Firstly, we use certain discrete points to represent the spherical surface in the phase velocity space. Then, integrals along the spherical surface for conservation forms of moments, which are needed to recover 3D Navier-Stokes equations, are approximated by integral quadrature. The basic requirement is that these conservation forms of moments can be exactly satisfied by weighted summation of distribution functions at discrete points. It was found that the integral quadrature by eight discrete points on the spherical surface, which forms the D3Q8 discrete velocity model, can exactly match the integral. In this way, the conservative variables and numerical fluxes can be computed by weighted summation of distribution functions at eight discrete points. That is, the application of complicated formulations resultant from integrals can be replaced by a simple solution process. Several numerical examples including laminar flat plate boundary layer, 3D lid-driven cavity flow, steady flow through a 90° bending square duct, transonic flow around DPW-W1 wing and supersonic flow around NACA0012 airfoil are chosen to validate the proposed scheme. Numerical results demonstrate that the present scheme can provide reasonable numerical results for 3D viscous flows.

  18. Modelling pulmonary blood flow

    PubMed Central

    Tawhai, Merryn H.; Burrowes, Kelly S.

    2008-01-01

    Computational model analysis is a method that has been used widely to understand and interpret complexity of interactions in the pulmonary system. Pulmonary blood transport is a multi-scale phenomenon that involves scale-dependent structure and function, therefore requiring different model assumptions for the microcirculation and the arterial or venous flows. The blood transport systems interact with the surrounding lung tissue, and are dependent on hydrostatic pressure gradients, control of vasoconstriction, and the topology and material composition of the vascular trees. This review focuses on computational models that have been developed to study the different mechanisms contributing to regional perfusion of the lung. Different models for the microcirculation and the pulmonary arteries are considered, including fractal approaches and anatomically-based methods. The studies that are reviewed illustrate the different complementary approaches that can be used to address the same physiological question of flow heterogeneity. PMID:18434260

  19. Implementation of Advanced Two Equation Turbulence Models in the USM3D Unstructured Flow Solver

    NASA Technical Reports Server (NTRS)

    Wang, Qun-Zhen; Massey, Steven J.; Abdol-Hamid, Khaled S.

    2000-01-01

    USM3D is a widely-used unstructured flow solver for simulating inviscid and viscous flows over complex geometries. The current version (version 5.0) of USM3D, however, does not have advanced turbulence models to accurately simulate complicated flow. We have implemented two modified versions of the original Jones and Launder k-epsilon "two-equation" turbulence model and the Girimaji algebraic Reynolds stress model in USM3D. Tests have been conducted for three flat plate boundary layer cases, a RAE2822 airfoil and an ONERA M6 wing. The results are compared with those from direct numerical simulation, empirical formulae, theoretical results, and the existing Spalart-Allmaras one-equation model.

  20. 3D Structures: Microfluidic Stamping on Sheath Flow (Small 24/2016).

    PubMed

    Yoon, Dong Hyun; Tanaka, Daiki; Sekiguchi, Tetsushi; Shoji, Shuichi

    2016-06-01

    A microfluidic stamping method to form functional shapes on a cross section in fibre-shaped flow is presented by D. H. Yoon and co-workers on page 3224. Microfluidic stamping and overstamping allowed various cross sectional shapes on the three-dimensional flow. Dimension of the flows is controlled via a change in combination of 3D structures and fluidic conditions, which correspond to stamp type and stamping force. PMID:27306739

  1. High fidelity digital inline holographic method for 3D flow measurements.

    PubMed

    Toloui, Mostafa; Hong, Jiarong

    2015-10-19

    Among all the 3D optical flow diagnostic techniques, digital inline holographic particle tracking velocimetry (DIH-PTV) provides the highest spatial resolution with low cost, simple and compact optical setups. Despite these advantages, DIH-PTV suffers from major limitations including poor longitudinal resolution, human intervention (i.e. requirement for manually determined tuning parameters during tracer field reconstruction and extraction), limited tracer concentration, and expensive computations. These limitations prevent this technique from being widely used for high resolution 3D flow measurements. In this study, we present a novel holographic particle extraction method with the goal of overcoming all the major limitations of DIH-PTV. The proposed method consists of multiple steps involving 3D deconvolution, automatic signal-to-noise ratio enhancement and thresholding, and inverse iterative particle extraction. The entire method is implemented using GPU-based algorithm to increase the computational speed significantly. Validated with synthetic particle holograms, the proposed method can achieve particle extraction rate above 95% with fake particles less than 3% and maximum position error below 1.6 particle diameter for holograms with particle concentration above 3000 particles/mm3. The applicability of the proposed method for DIH-PTV has been further validated using the experiment of laminar flow in a microchannel and the synthetic tracer flow fields generated using a DNS turbulent channel flow database. Such improvements will substantially enhance the implementation of DIH-PTV for 3D flow measurements and enable the potential commercialization of this technique. PMID:26480377

  2. Time-lapse 3-D seismic imaging of shallow subsurface contaminant flow.

    PubMed

    McKenna, J; Sherlock, D; Evans, B

    2001-12-01

    This paper presents a physical modelling study outlining a technique whereby buoyant contaminant flow within water-saturated unconsolidated sand was remotely monitored utilizing the time-lapse 3-D (TL3-D) seismic response. The controlled temperature and pressure conditions, along with the high level of acquisition repeatability attainable using sandbox physical models, allow the TL3-D seismic response to pore fluid movement to be distinguished from all other effects. TL3-D seismic techniques are currently being developed to monitor hydrocarbon reserves within producing reservoirs in an endeavour to improve overall recovery. However, in many ways, sandbox models under atmospheric conditions more accurately simulate the shallow subsurface than petroleum reservoirs. For this reason, perhaps the greatest application for analogue sandbox modelling is to improve our understanding of shallow groundwater and environmental flow mechanisms. Two fluid flow simulations were conducted whereby air and kerosene were injected into separate water-saturated unconsolidated sand models. In both experiments, a base 3-D seismic volume was recorded and compared with six later monitor surveys recorded while the injection program was conducted. Normal incidence amplitude and P-wave velocity information were extracted from the TL3-D seismic data to provide visualization of contaminant migration. Reflection amplitudes displayed qualitative areal distribution of fluids when a suitable impedance contrast existed between pore fluids. TL3-D seismic reflection tomography can potentially monitor the change in areal distribution of fluid contaminants over time, indicating flow patterns. However, other research and this current work have not established a quantifiable relationship between either normal reflection amplitudes and attenuation and fluid saturation. Generally, different pore fluids will have unique seismic velocities due to differences in compressibility and density. The predictable

  3. Parallel Finite Element Solution of 3D Rayleigh-Benard-Marangoni Flows

    NASA Technical Reports Server (NTRS)

    Carey, G. F.; McLay, R.; Bicken, G.; Barth, B.; Pehlivanov, A.

    1999-01-01

    A domain decomposition strategy and parallel gradient-type iterative solution scheme have been developed and implemented for computation of complex 3D viscous flow problems involving heat transfer and surface tension effects. Details of the implementation issues are described together with associated performance and scalability studies. Representative Rayleigh-Benard and microgravity Marangoni flow calculations and performance results on the Cray T3D and T3E are presented. The work is currently being extended to tightly-coupled parallel "Beowulf-type" PC clusters and we present some preliminary performance results on this platform. We also describe progress on related work on hierarchic data extraction for visualization.

  4. 3D cultured immortalized human hepatocytes useful to develop drugs for blood-borne HCV

    SciTech Connect

    Aly, Hussein Hassan; Shimotohno, Kunitada; Hijikata, Makoto

    2009-02-06

    Due to the high polymorphism of natural hepatitis C virus (HCV) variants, existing recombinant HCV replication models have failed to be effective in developing effective anti-HCV agents. In the current study, we describe an in vitro system that supports the infection and replication of natural HCV from patient blood using an immortalized primary human hepatocyte cell line cultured in a three-dimensional (3D) culture system. Comparison of the gene expression profile of cells cultured in the 3D system to those cultured in the existing 2D system demonstrated an up-regulation of several genes activated by peroxisome proliferator-activated receptor alpha (PPAR{alpha}) signaling. Furthermore, using PPAR{alpha} agonists and antagonists, we also analyzed the effect of PPAR{alpha} signaling on the modulation of HCV replication using this system. The 3D in vitro system described in this study provides significant insight into the search for novel anti-HCV strategies that are specific to various strains of HCV.

  5. 3-D model of a radial flow sub-watt methanol fuel processor

    SciTech Connect

    Holladay, J. D.; Wang, Y.

    2015-10-01

    A 3-D model is presented for a novel sub-watt packed bed reactor. The reactor uses an annular inlet flow combined with a radial flow packed bed reactor. The baseline reactor is compared to a reactor with multiple outlets and a reactor with 3 internal fins. Increasing the outlets from 1 to 4 did improve the flow distribution, but did not increase the performance in the simulation. However, inserting fins allowed a decrease in temperature with same inlet flow of approximately 35K. Or the inlet flow rate could be increased by a factor of 2.8x while maintaining >99% conversion.

  6. 3D-printed and CNC milled flow-cells for chemiluminescence detection.

    PubMed

    Spilstead, Kara B; Learey, Jessica J; Doeven, Egan H; Barbante, Gregory J; Mohr, Stephan; Barnett, Neil W; Terry, Jessica M; Hall, Robynne M; Francis, Paul S

    2014-08-01

    Herein we explore modern fabrication techniques for the development of chemiluminescence detection flow-cells with features not attainable using the traditional coiled tubing approach. This includes the first 3D-printed chemiluminescence flow-cells, and a milled flow-cell designed to split the analyte stream into two separate detection zones within the same polymer chip. The flow-cells are compared to conventional detection systems using flow injection analysis (FIA) and high performance liquid chromatography (HPLC), with the fast chemiluminescence reactions of an acidic potassium permanganate reagent with morphine and a series of adrenergic phenolic amines. PMID:24881540

  7. Numerical Optimization Strategy for Determining 3D Flow Fields in Microfluidics

    NASA Astrophysics Data System (ADS)

    Eden, Alex; Sigurdson, Marin; Mezic, Igor; Meinhart, Carl

    2015-11-01

    We present a hybrid experimental-numerical method for generating 3D flow fields from 2D PIV experimental data. An optimization algorithm is applied to a theory-based simulation of an alternating current electrothermal (ACET) micromixer in conjunction with 2D PIV data to generate an improved representation of 3D steady state flow conditions. These results can be used to investigate mixing phenomena. Experimental conditions were simulated using COMSOL Multiphysics to solve the temperature and velocity fields, as well as the quasi-static electric fields. The governing equations were based on a theoretical model for ac electrothermal flows. A Nelder-Mead optimization algorithm was used to achieve a better fit by minimizing the error between 2D PIV experimental velocity data and numerical simulation results at the measurement plane. By applying this hybrid method, the normalized RMS velocity error between the simulation and experimental results was reduced by more than an order of magnitude. The optimization algorithm altered 3D fluid circulation patterns considerably, providing a more accurate representation of the 3D experimental flow field. This method can be generalized to a wide variety of flow problems. This research was supported by the Institute for Collaborative Biotechnologies through grant W911NF-09-0001 from the U.S. Army Research Office.

  8. One-layer microfluidic device for hydrodynamic 3D self-flow-focusing operating in low flow speed

    NASA Astrophysics Data System (ADS)

    Daghighi, Yasaman; Gnyawali, Vaskar; Strohm, Eric M.; Tsai, Scott S. H.; Kolios, Michael C.

    2016-03-01

    Hydrodynamic 3D flow-focusing techniques in microfluidics are categorized as (a) sheathless techniques which require high flow rates and long channels, resulting in high operating cost and high flow rates which are inappropriate for applications with flow rate limitations, and (b) sheath-flow based techniques which usually require excessive sheath flow rate to achieve hydrodynamic 3D flow-focusing. Many devices based on these principles use complicated fabrication methods to create multi-layer microchannels. We have developed a sheath-flow based microfluidic device that is capable of hydrodynamic 3D self-flow-focusing. In this device the main flow (black ink) in a low speed, and a sheath flow, enter through two inlets and enter a 180 degree curved channel (300 × 300 μm cross-section). Main flow migrates outwards into the sheath-flow due to centrifugal effects and consequently, vertical focusing is achieved at the end of the curved channel. Then, two other sheath flows horizontally confine the main flow to achieve horizontal focusing. Thus, the core flow is three-dimensionally focused at the center of the channel at the downstream. Using centrifugal force for 3D flow-focusing in a single-layer fabricated microchannel has been previously investigated by few groups. However, their demonstrated designs required high flow speed (>1 m/s) which is not suitable for many applications that live biomedical specie are involved. Here, we introduce a new design which is operational in low flow speed (<0.05 m/s) and is suitable for applications involving live cells. This microfluidic device can be used in detecting, counting and isolating cells in many biomedical applications.

  9. Blood Pool Segmentation Results in Superior Virtual Cardiac Models than Myocardial Segmentation for 3D Printing.

    PubMed

    Farooqi, Kanwal M; Lengua, Carlos Gonzalez; Weinberg, Alan D; Nielsen, James C; Sanz, Javier

    2016-08-01

    The method of cardiac magnetic resonance (CMR) three-dimensional (3D) image acquisition and post-processing which should be used to create optimal virtual models for 3D printing has not been studied systematically. Patients (n = 19) who had undergone CMR including both 3D balanced steady-state free precession (bSSFP) imaging and contrast-enhanced magnetic resonance angiography (MRA) were retrospectively identified. Post-processing for the creation of virtual 3D models involved using both myocardial (MS) and blood pool (BP) segmentation, resulting in four groups: Group 1-bSSFP/MS, Group 2-bSSFP/BP, Group 3-MRA/MS and Group 4-MRA/BP. The models created were assessed by two raters for overall quality (1-poor; 2-good; 3-excellent) and ability to identify predefined vessels (1-5: superior vena cava, inferior vena cava, main pulmonary artery, ascending aorta and at least one pulmonary vein). A total of 76 virtual models were created from 19 patient CMR datasets. The mean overall quality scores for Raters 1/2 were 1.63 ± 0.50/1.26 ± 0.45 for Group 1, 2.12 ± 0.50/2.26 ± 0.73 for Group 2, 1.74 ± 0.56/1.53 ± 0.61 for Group 3 and 2.26 ± 0.65/2.68 ± 0.48 for Group 4. The numbers of identified vessels for Raters 1/2 were 4.11 ± 1.32/4.05 ± 1.31 for Group 1, 4.90 ± 0.46/4.95 ± 0.23 for Group 2, 4.32 ± 1.00/4.47 ± 0.84 for Group 3 and 4.74 ± 0.56/4.63 ± 0.49 for Group 4. Models created using BP segmentation (Groups 2 and 4) received significantly higher ratings than those created using MS for both overall quality and number of vessels visualized (p < 0.05), regardless of the acquisition technique. There were no significant differences between Groups 1 and 3. The ratings for Raters 1 and 2 had good correlation for overall quality (ICC = 0.63) and excellent correlation for the total number of vessels visualized (ICC = 0.77). The intra-rater reliability was good for Rater A (ICC = 0.65). Three models were successfully printed

  10. Blood Pool Segmentation Results in Superior Virtual Cardiac Models than Myocardial Segmentation for 3D Printing.

    PubMed

    Farooqi, Kanwal M; Lengua, Carlos Gonzalez; Weinberg, Alan D; Nielsen, James C; Sanz, Javier

    2016-08-01

    The method of cardiac magnetic resonance (CMR) three-dimensional (3D) image acquisition and post-processing which should be used to create optimal virtual models for 3D printing has not been studied systematically. Patients (n = 19) who had undergone CMR including both 3D balanced steady-state free precession (bSSFP) imaging and contrast-enhanced magnetic resonance angiography (MRA) were retrospectively identified. Post-processing for the creation of virtual 3D models involved using both myocardial (MS) and blood pool (BP) segmentation, resulting in four groups: Group 1-bSSFP/MS, Group 2-bSSFP/BP, Group 3-MRA/MS and Group 4-MRA/BP. The models created were assessed by two raters for overall quality (1-poor; 2-good; 3-excellent) and ability to identify predefined vessels (1-5: superior vena cava, inferior vena cava, main pulmonary artery, ascending aorta and at least one pulmonary vein). A total of 76 virtual models were created from 19 patient CMR datasets. The mean overall quality scores for Raters 1/2 were 1.63 ± 0.50/1.26 ± 0.45 for Group 1, 2.12 ± 0.50/2.26 ± 0.73 for Group 2, 1.74 ± 0.56/1.53 ± 0.61 for Group 3 and 2.26 ± 0.65/2.68 ± 0.48 for Group 4. The numbers of identified vessels for Raters 1/2 were 4.11 ± 1.32/4.05 ± 1.31 for Group 1, 4.90 ± 0.46/4.95 ± 0.23 for Group 2, 4.32 ± 1.00/4.47 ± 0.84 for Group 3 and 4.74 ± 0.56/4.63 ± 0.49 for Group 4. Models created using BP segmentation (Groups 2 and 4) received significantly higher ratings than those created using MS for both overall quality and number of vessels visualized (p < 0.05), regardless of the acquisition technique. There were no significant differences between Groups 1 and 3. The ratings for Raters 1 and 2 had good correlation for overall quality (ICC = 0.63) and excellent correlation for the total number of vessels visualized (ICC = 0.77). The intra-rater reliability was good for Rater A (ICC = 0.65). Three models were successfully printed

  11. Building Chondrites: SPH Simulations of a Jet Flow in a 3D Protoplanetary Disc

    NASA Astrophysics Data System (ADS)

    Pignatale, F. C.; Gonzalez, J.-F.; Cuello, N.; Bourdon, B.; Fitoussi, C.

    2016-08-01

    We present SPH simulations of jet flows in 3D discs to investigate the transport of refractory material toward the outer cold disc regions. Dust grains are captured by the disc at distances up to 40 AU, with dust aggregates mimicking chondrites.

  12. Tracking left ventricular borders in 3D echocardiographic sequences using motion-guided optical flow

    NASA Astrophysics Data System (ADS)

    Leung, K. Y. Esther; Danilouchkine, Mikhail G.; van Stralen, Marijn; de Jong, Nico; van der Steen, Antonius F. W.; Bosch, Johan G.

    2009-02-01

    For obtaining quantitative and objective functional parameters from three-dimensional (3D) echocardiographic sequences, automated segmentation methods may be preferable to cumbersome manual delineation of 3D borders. In this study, a novel optical-flow based tracking method is proposed for propagating 3D endocardial contours of the left ventricle throughout the cardiac cycle. To take full advantage of the time-continuous nature of cardiac motion, a statistical motion model was explicitly embedded in the optical flow solution. The cardiac motion was modeled as frame-to-frame affine transforms, which were extracted using Procrustes analysis on a set of training contours. Principal component analysis was applied to obtain a compact model of cardiac motion throughout the whole cardiac cycle. The parameters of this model were resolved in an optical flow manner, via spatial and temporal gradients in image intensity. The algorithm was tested on 36 noncontrast and 28 contrast enhanced 3D echocardiographic sequences in a leave-one-out manner. Good results were obtained using a combination of the proposed motion-guided method and a purely data-driven optical flow approach. The improvement was particularly noticeable in areas where the LV wall was obscured by image artifacts. In conclusion, the results show the applicability of the proposed method in clinical quality echocardiograms.

  13. Finite volume and finite element methods applied to 3D laminar and turbulent channel flows

    SciTech Connect

    Louda, Petr; Příhoda, Jaromír; Sváček, Petr; Kozel, Karel

    2014-12-10

    The work deals with numerical simulations of incompressible flow in channels with rectangular cross section. The rectangular cross section itself leads to development of various secondary flow patterns, where accuracy of simulation is influenced by numerical viscosity of the scheme and by turbulence modeling. In this work some developments of stabilized finite element method are presented. Its results are compared with those of an implicit finite volume method also described, in laminar and turbulent flows. It is shown that numerical viscosity can cause errors of same magnitude as different turbulence models. The finite volume method is also applied to 3D turbulent flow around backward facing step and good agreement with 3D experimental results is obtained.

  14. Comparison of Tomo-PIV and 3D-PTV for microfluidic flows

    NASA Astrophysics Data System (ADS)

    Kim, Hyoungsoo; Westerweel, Jerry; Elsinga, Gerrit E.

    2013-02-01

    Two 3D-3C velocimetry techniques for micro-scale measurements are compared: tomographic particle image velocimetry (Tomo-PIV) and 3D particle-tracking velocimetry (3D-PTV). Both methods are applied to experimental data from a confined shear-driven liquid droplet over a moving surface. The droplet has 200 μm height and 2 mm diameter. Micro 3D-PTV and Tomo-PIV are used to obtain the tracer particle distribution and the flow velocity field for the same set of images. It is shown that the reconstructed particle distributions are distinctly different, where Tomo-PIV returns a nearly uniform distribution over the height of the volume, as expected, and PTV reveals a clear peak in the particle distribution near the plane of focus. In Tomo-PIV, however, the reconstructed particle peak intensity decreases in proportion to the distance from the plane of focus. Due to the differences in particle distributions, the measured flow velocities are also different. In particular, we observe Tomo-PIV to be in closer agreement with mass conservation. Furthermore, the random noise level is found to increase with distance to the plane of focus at a higher rate for 3D-PTV as compared to Tomo-PIV. Thus, for a given noise threshold value, the latter method can measure reliably over a thicker volume.

  15. 3-D Flow Field Diagnostics and Validation Studies using Stereoscopic Tracking Velocimetry

    NASA Technical Reports Server (NTRS)

    Cha, Soyoung Stephen; Ramachandran, Narayanan; Whitaker, Ann F. (Technical Monitor)

    2002-01-01

    The measurement of 3-D three-component velocity fields is of great importance in both ground and space experiments for understanding materials processing and fluid physics. Here, we present the investigation results of stereoscopic tracking velocimetry (STV) for measuring 3-D velocity fields. The effort includes diagnostic technology development, experimental velocity measurement, and comparison with analytical and numerical computation. The advantages of STV stems from the system simplicity for building compact hardware and in software efficiency for continual near-real-time process monitoring. It also has illumination flexibility for observing volumetric flow fields from arbitrary directions. STV is based on stereoscopic CCD observations of particles seeded in a flow. Neural networks are used for data analysis. The developed diagnostic tool is tested with a simple directional solidification apparatus using Succinonitrile. The 3-D velocity field in the liquid phase is measured and compared with results from detailed numerical computations. Our theoretical, numerical, and experimental effort has shown STV to be a viable candidate for reliably quantifying the 3-D flow field in materials processing and fluids experiments.

  16. An improved parallel SPH approach to solve 3D transient generalized Newtonian free surface flows

    NASA Astrophysics Data System (ADS)

    Ren, Jinlian; Jiang, Tao; Lu, Weigang; Li, Gang

    2016-08-01

    In this paper, a corrected parallel smoothed particle hydrodynamics (C-SPH) method is proposed to simulate the 3D generalized Newtonian free surface flows with low Reynolds number, especially the 3D viscous jets buckling problems are investigated. The proposed C-SPH method is achieved by coupling an improved SPH method based on the incompressible condition with the traditional SPH (TSPH), that is, the improved SPH with diffusive term and first-order Kernel gradient correction scheme is used in the interior of the fluid domain, and the TSPH is used near the free surface. Thus the C-SPH method possesses the advantages of two methods. Meanwhile, an effective and convenient boundary treatment is presented to deal with 3D multiple-boundary problem, and the MPI parallelization technique with a dynamic cells neighbor particle searching method is considered to improve the computational efficiency. The validity and the merits of the C-SPH are first verified by solving several benchmarks and compared with other results. Then the viscous jet folding/coiling based on the Cross model is simulated by the C-SPH method and compared with other experimental or numerical results. Specially, the influences of macroscopic parameters on the flow are discussed. All the numerical results agree well with available data, and show that the C-SPH method has higher accuracy and better stability for solving 3D moving free surface flows over other particle methods.

  17. A fast and accurate method to predict 2D and 3D aerodynamic boundary layer flows

    NASA Astrophysics Data System (ADS)

    Bijleveld, H. A.; Veldman, A. E. P.

    2014-12-01

    A quasi-simultaneous interaction method is applied to predict 2D and 3D aerodynamic flows. This method is suitable for offshore wind turbine design software as it is a very accurate and computationally reasonably cheap method. This study shows the results for a NACA 0012 airfoil. The two applied solvers converge to the experimental values when the grid is refined. We also show that in separation the eigenvalues remain positive thus avoiding the Goldstein singularity at separation. In 3D we show a flow over a dent in which separation occurs. A rotating flat plat is used to show the applicability of the method for rotating flows. The shown capabilities of the method indicate that the quasi-simultaneous interaction method is suitable for design methods for offshore wind turbine blades.

  18. Delft3D-FLOW on PRACE infrastructures for real life hydrodynamic applications.

    NASA Astrophysics Data System (ADS)

    Donners, John; Genseberger, Menno; Jagers, Bert; de Goede, Erik; Mourits, Adri

    2013-04-01

    PRACE, the Partnership for Advanced Computing in Europe, offers access to the largest high-performance computing systems in Europe. PRACE invites and helps industry to increase their innovative potential through the use of the PRACE infrastructure. This poster describes different efforts to assist Deltares with porting the open-source simulation software Delft3D-FLOW to PRACE infrastructures. Analysis of the performance on these infrastructures has been done for real life flow applications. Delft3D-FLOW is a 2D and 3D shallow water solver which calculates non-steady flow and transport phenomena resulting from tidal and meteorological forcing on a curvilinear, boundary fitted grid in Cartesian or spherical coordinates. It also includes a module which sediment transport (both suspended and bed total load) and morphological changes for an arbitrary number of cohesive and non-cohesive fractions. As Delft3D-FLOW has been developed over several decades, with a variety of functionality and over 350k lines of source code, porting to PRACE infrastructures needs some effort. At the moment Delft3D-FLOW uses MPI with domain decomposition in one direction as its parallellisation approach. Because it is hard to identify scaling issues if one immediately starts with a complex case with many features enabled, different cases with increasing complexity have been used to investigate scaling of this parallellisation approach on several PRACE platforms. As a base reference case we started with a schematic high-resolution 2D hydrodynamic model of the river Waal that turned out to be surprisingly well-suited to the highly-parallel PRACE machines. Although Delft3D-FLOW employs a sophisticated build system, several modifications were required to port it to most PRACE systems due to the use of specific, highly-tuned compilers and MPI-libraries. After this we moved to a 3D hydrodynamic model of Rotterdam harbour that includes sections of the rivers Rhine and Meuse and a part of the North

  19. Experimental Investigation of the Near Wall Flow Structure of a Low Reynolds Number 3-D Turbulent Boundary Layer

    NASA Technical Reports Server (NTRS)

    Fleming, J. L.; Simpson, R. L.

    1997-01-01

    Laser Doppler velocimetry (LDV) measurements and hydrogen bubble flow visualization techniques were used to examine the near-wall flow structure of 2D and 3D turbulent boundary layers (TBLs) over a range of low Reynolds numbers. The goals of this research were (1) an increased understanding of the flow physics in the near wall region of turbulent boundary layers,(2) to observe and quantify differences between 2D and 3D TBL flow structures, and (3) to document Reynolds number effects for 3D TBLs. The LDV data have provided results detailing the turbulence structure of the 2D and 3D TBLs. These results include mean Reynolds stress distributions, flow skewing results, and U and V spectra. Effects of Reynolds number for the 3D flow were also examined. Comparison to results with the same 3D flow geometry but at a significantly higher Reynolds number provided unique insight into the structure of 3D TBLs. While the 3D mean and fluctuating velocities were found to be highly dependent on Reynolds number, a previously defined shear stress parameter was discovered to be invariant with Reynolds number. The hydrogen bubble technique was used as a flow visualization tool to examine the near-wall flow structure of 2D and 3D TBLs. Both the quantitative and qualitative results displayed larger turbulent fluctuations with more highly concentrated vorticity regions for the 2D flow.

  20. Multigrid Computations of 3-D Incompressible Internal and External Viscous Rotating Flows

    NASA Technical Reports Server (NTRS)

    Sheng, Chunhua; Taylor, Lafayette K.; Chen, Jen-Ping; Jiang, Min-Yee; Whitfield, David L.

    1996-01-01

    This report presents multigrid methods for solving the 3-D incompressible viscous rotating flows in a NASA low-speed centrifugal compressor and a marine propeller 4119. Numerical formulations are given in both the rotating reference frame and the absolute frame. Comparisons are made for the accuracy, efficiency, and robustness between the steady-state scheme and the time-accurate scheme for simulating viscous rotating flows for complex internal and external flow applications. Prospects for further increase in efficiency and accuracy of unsteady time-accurate computations are discussed.

  1. Effects of 3D PIV post-processing on impulse and force analysis in vortical flows

    NASA Astrophysics Data System (ADS)

    Mendelson, Leah; Techet, Alexandra

    2014-11-01

    Vortical flows measured using 3D PIV techniques are fundamentally filtered versions of physical phenomena, with velocity information lost below the length and time scales of the measurement system. In the context of propulsive vortices, such as those generated during biological locomotion, these factors, combined with experimental noise and error, can lead to inaccuracies in analysis of the vortex momentum and net thrust. As a result, while 3D velocity measurements remove many of the assumptions required to analyze planar PIV data, they should not be considered absolute physical quantities. Our work focuses on post-processing for 3D PIV data sets to enable the extraction of accurate, quantitative 3D force measurements for unsteady vortical propulsion. In this study, we compare utilizing measurement signal processing techniques, orthogonal decomposition, and identification of coherent structures to measure the impulse of a canonical vortex ring generated by a mechanical piston. In particular, we consider the ability of these methods to confront the influences of limited spatial resolution and arbitrary geometries, and make recommendations for a general procedure for propulsion analysis from 3D PIV data, regardless of which PIV technique is used to obtain the velocity fields.

  2. 3-D High-Lift Flow-Physics Experiment - Transition Measurements

    NASA Technical Reports Server (NTRS)

    McGinley, Catherine B.; Jenkins, Luther N.; Watson, Ralph D.; Bertelrud, Arild

    2005-01-01

    An analysis of the flow state on a trapezoidal wing model from the NASA 3-D High Lift Flow Physics Experiment is presented. The objective of the experiment was to characterize the flow over a non-proprietary semi-span three-element high-lift configuration to aid in assessing the state of the art in the computation of three-dimensional high-lift flows. Surface pressures and hot-film sensors are used to determine the flow conditions on the slat, main, and flap. The locations of the attachments lines and the values of the attachment line Reynolds number are estimated based on the model surface pressures. Data from the hot-films are used to determine if the flow is laminar, transitional, or turbulent by examining the hot-film time histories, statistics, and frequency spectra.

  3. Aspects of Turbulent Flow over 2D and 3D Bedforms

    NASA Astrophysics Data System (ADS)

    Venditti, J. G.; Church, M. A.

    2004-05-01

    Sediment transport in sand bedded alluvial channels is strongly conditioned by bedforms. Understanding the turbulent flow field over bedforms is crucial to understanding flow resistance in rivers. Most of the research on flow over bedforms has focused on straight crested, two-dimensional bedforms, and the characteristics of the turbulent flow field are fairly well understood. In contrast, few studies have examined flow over 3D bedforms, which typically have irregular heights, lengths, and crestlines. This paper reports on experiments undertaken to examine how 3D dune morphology affects the turbulent flow field and, ultimately, flow resistance. An experiment was designed to examine flow over fixed bedforms 0.45 m long and 25 mm high in a 0.5 m wide and 17 m long flume. In each experimental run, discharge and dune size were held constant, but the crest shape was varied. Flow over six bedform crest shapes was examined, including a 2D crest, a saddle shaped crest, a lobe shaped crest, a regular 3D crest alignment, an irregular 3D crest alignment and a sinuous crest. Measurements of velocity were made at a sampling rate of 50 Hz using an acoustic Doppler velocimeter at 350-500 points over a dune in each morphology. Three-dimensional bedforms significantly modify the flow field over a dune. Lobe shaped configurations cause lateral and vertical divergence of momentum and turbulent energy, thereby enhancing the level of turbulence compared to a 2D bedform. Saddle shaped crestlines cause lateral and vertical convergence of momentum and turbulent energy towards a small area in the lee, thereby reducing the level of turbulence. Other bedform morphologies (regular, irregular and sinuous crests) exhibited characteristics of both lobes and saddles, but the net effect was to reduce levels of turbulence. Total drag, calculated from spatially averaged Reynolds stress profiles, can be enhanced or reduced by as much as 50 %. These results suggest that current conceptions of bedforms

  4. Simulation of 3-D Nonequilibrium Seeded Air Flow in the NASA-Ames MHD Channel

    NASA Technical Reports Server (NTRS)

    Gupta, Sumeet; Tannehill, John C.; Mehta, Unmeel B.

    2004-01-01

    The 3-D nonequilibrium seeded air flow in the NASA-Ames experimental MHD channel has been numerically simulated. The channel contains a nozzle section, a center section, and an accelerator section where magnetic and electric fields can be imposed on the flow. In recent tests, velocity increases of up to 40% have been achieved in the accelerator section. The flow in the channel is numerically computed us ing a 3-D parabolized Navier-Stokes (PNS) algorithm that has been developed to efficiently compute MHD flows in the low magnetic Reynolds number regime: The MHD effects are modeled by introducing source terms into the PNS equations which can then be solved in a very efficient manner. The algorithm has been extended in the present study to account for nonequilibrium seeded air flows. The electrical conductivity of the flow is determined using the program of Park. The new algorithm has been used to compute two test cases that match the experimental conditions. In both cases, magnetic and electric fields are applied to the seeded flow. The computed results are in good agreement with the experimental data.

  5. Quasi 3D modeling of water flow and solute transport in vadose zone and groundwater

    NASA Astrophysics Data System (ADS)

    Yakirevich, A.; Kuznetsov, M.; Weisbrod, N.; Pachepsky, Y. A.

    2013-12-01

    The complexity of subsurface flow systems calls for a variety of concepts leading to the multiplicity of simplified flow models. One commonly used simplification is based on the assumption that lateral flow and transport in unsaturated zone is insignificant unless the capillary fringe is involved. In such cases the flow and transport in the unsaturated zone above groundwater level can be simulated as a 1D phenomenon, whereas through groundwater they are viewed as 2D or 3D phenomena. A new approach for a numerical scheme for 3D variably saturated flow and transport is presented. A Quasi-3D approach allows representing flow in the 'vadose zone - aquifer' system by a series of 1D Richards' equations solved in variably-saturated zone and by 3D-saturated flow equation in groundwater (modified MODFLOW code). The 1D and 3D equations are coupled at the phreatic surface in a way that aquifer replenishment is calculated using the Richards' equation, and solving for the moving water table does not require definition of the specific yield parameter. The 3D advection-dispersion equation is solved in the entire domain by the MT3D code. Using implicit finite differences approximation to couple processes in the vadose zone and groundwater provides mass conservation and increase of computational efficiency. The above model was applied to simulate the impact of irrigation on groundwater salinity in the Alto Piura aquifer (Northern Peru). Studies on changing groundwater quality in arid and semi-arid lands show that irrigation return flow is one of the major factors contributing to aquifer salinization. Existing mathematical models do not account explicitly for the solute recycling during irrigation on a daily scale. Recycling occurs throughout the unsaturated and saturated zones, as function of the solute mass extracted from pumping wells. Salt concentration in irrigation water is calculated at each time step as a function of concentration of both surface water and groundwater

  6. Evaluation of the 3-D channeling flow in a fractured type of oil/gas reservoir

    NASA Astrophysics Data System (ADS)

    Ishibashi, T.; Watanabe, N.; Tsuchiya, N.; Tamagawa, T.

    2013-12-01

    An understanding of the flow and transport characteristics through rock fracture networks is of critical importance in many engineering and scientific applications. These include effective recovery of targeted fluid such as oil/gas, geothermal, or potable waters, and isolation of hazardous materials. Here, the formation of preferential flow path (i.e. channeling flow) is one of the most significant characteristics in considering fluid flow through rock fracture networks; however, the impact of channeling flow remains poorly understood. In order to deepen our understanding of channeling flow, the authors have developed a novel discrete fracture network (DFN) model simulator, GeoFlow. Different from the conventional DFN model simulators, we can characterize each fracture not by a single aperture value but by a heterogeneous aperture distribution in GeoFlow [Ishibashi et al., 2012]. As a result, the formation of 3-D preferential flow paths within fracture network can be considered by using this simulator. Therefore, we would challenge to construct the precise fracture networks whose fractures have heterogeneous aperture distributions in field scale, and to analyze fluid flows through the fracture networks by GeoFlow. In the present study, the Yufutsu oil/gas field in Hokkaido, Japan is selected as the subject area for study. This field is known as the fractured type of reservoir, and reliable DFN models can be constructed for this field based on the 3-D seismic data, well logging, in-situ stress measurement, and acoustic emission data [Tamagawa et al., 2012]. Based on these DFN models, new DFN models for 1,080 (East-West) × 1,080 (North-South) × 1,080 (Depth) m^3, where fractures are represented by squares of 44-346 m on a side, are re-constructed. In these new models, scale-dependent aperture distributions are considered for all fractures constructing the fracture networks. Note that the multi-scale modeling of fracture flow has been developed by the authors

  7. Accurate 3D reconstruction of complex blood vessel geometries from intravascular ultrasound images: in vitro study.

    PubMed

    Subramanian, K R; Thubrikar, M J; Fowler, B; Mostafavi, M T; Funk, M W

    2000-01-01

    We present a technique that accurately reconstructs complex three dimensional blood vessel geometry from 2D intravascular ultrasound (IVUS) images. Biplane x-ray fluoroscopy is used to image the ultrasound catheter tip at a few key points along its path as the catheter is pulled through the blood vessel. An interpolating spline describes the continuous catheter path. The IVUS images are located orthogonal to the path, resulting in a non-uniform structured scalar volume of echo densities. Isocontour surfaces are used to view the vessel geometry, while transparency and clipping enable interactive exploration of interior structures. The two geometries studied are a bovine artery vascular graft having U-shape and a constriction, and a canine carotid artery having multiple branches and a constriction. Accuracy of the reconstructions is established by comparing the reconstructions to (1) silicone moulds of the vessel interior, (2) biplane x-ray images, and (3) the original echo images. Excellent shape and geometry correspondence was observed in both geometries. Quantitative measurements made at key locations of the 3D reconstructions also were in good agreement with those made in silicone moulds. The proposed technique is easily adoptable in clinical practice, since it uses x-rays with minimal exposure and existing IVUS technology. PMID:11105284

  8. Lattice Boltzmann Simulation of a Flow over a 3D Cube in a wind Tunnel

    NASA Astrophysics Data System (ADS)

    Shock, Richard; Chen, Hudong; Yakhot, Victor

    2001-06-01

    It is argued that even a simplified version of the Boltzmann equation in a relaxation time approximation is equivalent to the hydrodynamic equations, involving infinite number of non-linear terms. Used for turbulence modelling, where the relaxation time and mean -free path are both space and field dependent, this equation is equivalent to the classic Navier-Stokes + turbulent model representations, provided the gradients are small. If, however, the non-equilibrium effects are strong, all higher non-linearities cannot be neglected. Thus, the Boltmann approximation can be extremely usefull for description of strongly non-equilibrium and time - dependent flows. This fact has been demonstrated on a wide variety of flows of both academic and industrial interest ranging from a simple 2D channel flow to 3D flows over various production cars. In this talk the quality of the approach is demonstrated on a simulation of the flow over a 3D cube in a wind tunnel. The predicted parameters of this strongly unsteady flow are compared with experimental data. The agreement is very good.

  9. Simulation of a 3D unsteady flow in an axial turbine stage

    NASA Astrophysics Data System (ADS)

    Straka, Petr

    2012-04-01

    The contribution deals with a numerical simulation of an unsteady flow in an axial turbine stage. The solution is performed using an in-house numerical code developed in the Aeronautical and Test Institute, Plc. in Prague. The numerical code is based on a finite volume discretization of governing equations (Favre averaged Navier-Stokes equations) and a two-equations turbulence model. The temporal integration is based on the implicit second-order backward Euler formula, which is realized through the iteration process in dual time. The proposed numerical method is used for solution of the 3D, unsteady, viscous turbulent flow of a perfect gas in the axial turbine stage. The flow path consists of an input nozzle, stator blade-wheel, rotor blade-wheel, a shroud-seal gap and a diffuser. Attention is paid to the influence of a secondary flow structures, such as generated vortices and flow in shroud-seal gap.

  10. Ultrarapid Detection of Pathogenic Bacteria Using a 3D Immunomagnetic Flow Assay

    PubMed Central

    Lee, Wonjae; Kwon, Donghoon; Chung, Boram; Jung, Gyoo Yeol; Au, Anthony; Folch, Albert; Jeon, Sangmin

    2015-01-01

    We developed a novel 3D immunomagnetic flow assay for the rapid detection of pathogenic bacteria in a large-volume food sample. Antibody-functionalized magnetic nanoparticle clusters (AbMNCs) were magnetically immobilized on the surfaces of a 3D-printed cylindrical microchannel. The injection of a Salmonella-spiked sample solution into the microchannel produced instant binding between the AbMNCs and the Salmonella bacteria due to their efficient collisions. Nearly perfect capture of the AbMNCs and AbMNCs-Salmonella complexes was achieved under a high flow rate by stacking permanent magnets with spacers inside the cylindrical separator to maximize the magnetic force. The concentration of the bacteria in solution was determined using ATP luminescence measurements. The detection limit was better than 10 cfu/mL, and the overall assay time, including the binding, rinsing, and detection steps for a 10 mL sample took less than 3 min. To our knowledge, the 3D immunomagnetic flow assay described here provides the fastest high-sensitivity, high-capacity method for the detection of pathogenic bacteria. PMID:24856003

  11. 3D hydro-mechanically coupled groundwater flow modelling of Pleistocene glaciation effects

    NASA Astrophysics Data System (ADS)

    Rühaak, Wolfram; Bense, Victor F.; Sass, Ingo

    2014-06-01

    Pleistocene glaciation led to temporal and spatial variations of sub-surface pore fluid pressure. In basins covered by ice sheets, fluid flow and recharge rates are strongly elevated during glaciations as compared to inter-glacial periods. Present-day hydrogeological conditions across formerly glaciated areas are likely to still reflect the impact of glaciations that ended locally more than 10 thousand years before present. 3D hydro-mechanical coupled modelling of glaciation can help to improve the management of groundwater resources in formerly glaciated basins. An open source numerical code for solving linear elasticity, which is based on the finite element method (FEM) in 3D, has been developed. By coupling this code with existing 3D flow codes it is possible to enable hydro-mechanical coupled modelling. Results of two benchmark simulations are compared to existing analytical solutions to demonstrate the performance of the newly developed code. While the result for a fluid-structure coupled case is in reasonable agreement with the analytical model, the result for a classical structure-fluid coupled benchmark showed that the analytical solution only matches the numerical result when the relevant coupling parameter (loading efficiency) is known in advance. This indicates that the applicability of widely applied approaches using an extra term in the groundwater flow equation for vertical stress to simulate hydro-mechanical coupling might have to be re-evaluated. A case study with the commercial groundwater simulator FEFLOW demonstrates the newly developed solution.

  12. Ultrarapid detection of pathogenic bacteria using a 3D immunomagnetic flow assay.

    PubMed

    Lee, Wonjae; Kwon, Donghoon; Chung, Boram; Jung, Gyoo Yeol; Au, Anthony; Folch, Albert; Jeon, Sangmin

    2014-07-01

    We developed a novel 3D immunomagnetic flow assay for the rapid detection of pathogenic bacteria in a large-volume food sample. Antibody-functionalized magnetic nanoparticle clusters (AbMNCs) were magnetically immobilized on the surfaces of a 3D-printed cylindrical microchannel. The injection of a Salmonella-spiked sample solution into the microchannel produced instant binding between the AbMNCs and the Salmonella bacteria due to their efficient collisions. Nearly perfect capture of the AbMNCs and AbMNCs-Salmonella complexes was achieved under a high flow rate by stacking permanent magnets with spacers inside the cylindrical separator to maximize the magnetic force. The concentration of the bacteria in solution was determined using ATP luminescence measurements. The detection limit was better than 10 cfu/mL, and the overall assay time, including the binding, rinsing, and detection steps for a 10 mL sample took less than 3 min. To our knowledge, the 3D immunomagnetic flow assay described here provides the fastest high-sensitivity, high-capacity method for the detection of pathogenic bacteria.

  13. Disorders of cochlear blood flow.

    PubMed

    Nakashima, Tsutomu; Naganawa, Shinji; Sone, Michihiko; Tominaga, Mitsuo; Hayashi, Hideo; Yamamoto, Hiroshi; Liu, Xiuli; Nuttall, Alfred L

    2003-09-01

    The cochlea is principally supplied from the inner ear artery (labyrinthine artery), which is usually a branch of the anterior inferior cerebellar artery. Cochlear blood flow is a function of cochlear perfusion pressure, which is calculated as the difference between mean arterial blood pressure and inner ear fluid pressure. Many otologic disorders such as noise-induced hearing loss, endolymphatic hydrops and presbycusis are suspected of being related to alterations in cochlear blood flow. However, the human cochlea is not easily accessible for investigation because this delicate sensory organ is hidden deep in the temporal bone. In patients with sensorineural hearing loss, magnetic resonance imaging, laser-Doppler flowmetry and ultrasonography have been used to investigate the status of cochlear blood flow. There have been many reports of hearing loss that were considered to be caused by blood flow disturbance in the cochlea. However, direct evidence of blood flow disturbance in the cochlea is still lacking in most of the cases.

  14. A modular segmented-flow platform for 3D cell cultivation.

    PubMed

    Lemke, Karen; Förster, Tobias; Römer, Robert; Quade, Mandy; Wiedemeier, Stefan; Grodrian, Andreas; Gastrock, Gunter

    2015-07-10

    In vitro 3D cell cultivation is promised to equate tissue in vivo more realistically than 2D cell cultivation corresponding to cell-cell and cell-matrix interactions. Therefore, a scalable 3D cultivation platform was developed. This platform, called pipe-based bioreactors (pbb), is based on the segmented-flow technology: aqueous droplets are embedded in a water-immiscible carrier fluid. The droplet volumes range from 60 nL to 20 μL and are used as bioreactors lined up in a tubing like pearls on a string. The modular automated platform basically consists of several modules like a fluid management for a high throughput droplet generation for self-assembly or scaffold-based 3D cell cultivation, a storage module for incubation and storage, and an analysis module for monitoring cell aggregation and proliferation basing on microscopy or photometry. In this report, the self-assembly of murine embryonic stem cells (mESCs) to uniformly sized embryoid bodies (EBs), the cell proliferation, the cell viability as well as the influence on the cell differentiation to cardiomyocytes are described. The integration of a dosage module for medium exchange or agent addition will enable pbb as long-term 3D cell cultivation system for studying stem cell differentiation, e.g. cardiac myogenesis or for diagnostic and therapeutic testing in personalized medicine.

  15. Contact Effects in thin 3D-Topological Insulators: How does the current flow?

    PubMed Central

    Gupta, Gaurav; Jalil, Mansoor Bin Abdul; Liang, Gengchiau

    2015-01-01

    The effect of different contact configurations (semi-infinite extended-channel, normal metal and ferromagnetic metal) on quantum transport through thin Bi2Se3 three-dimensional (3D) topological insulator (TI) slab (channel) has been investigated through Non-Equilibrium Green Function. The issue of contact dependent current flow and distribution across quintuple layers of 3D-TI has been addressed in this work and applied to expound the explanation for recent experimental work on electrical detection of spin-momentum locking on topological surface for long channel device. A theoretical model is propounded to develop a microscopic understanding of transport in 3D-TI in which contact type and magnetization concur with helical surface states of the TI channel to manifest seemingly counter-intuitive current distribution across layers. The quantum transport calculations for short channel devices with magnetic source and drain contacts postulate negative surface current for anti-phase magnetization whose axis is transverse to both current and quintuple layers. For in-phase magnetization at the two terminals, it is shown that observations can change fundamentally to result in anomalous current distribution. Such results are explained to stem from the confinement of 3D-TI between ferromagnetic contacts along the transport direction. A simple mechanism to validate topological insulators via quantum transport experiments has also been suggested. PMID:25820460

  16. Nonhydrostatic granular flow over 3-D terrain: New Boussinesq-type gravity waves?

    NASA Astrophysics Data System (ADS)

    Castro-Orgaz, Oscar; Hutter, Kolumban; Giraldez, Juan V.; Hager, Willi H.

    2015-01-01

    granular mass flow is a basic step in the prediction and control of natural or man-made disasters related to avalanches on the Earth. Savage and Hutter (1989) pioneered the mathematical modeling of these geophysical flows introducing Saint-Venant-type mass and momentum depth-averaged hydrostatic equations using the continuum mechanics approach. However, Denlinger and Iverson (2004) found that vertical accelerations in granular mass flows are of the same order as the gravity acceleration, requiring the consideration of nonhydrostatic modeling of granular mass flows. Although free surface water flow simulations based on nonhydrostatic depth-averaged models are commonly used since the works of Boussinesq (1872, 1877), they have not yet been applied to the modeling of debris flow. Can granular mass flow be described by Boussinesq-type gravity waves? This is a fundamental question to which an answer is required, given the potential to expand the successful Boussinesq-type water theory to granular flow over 3-D terrain. This issue is explored in this work by generalizing the basic Boussinesq-type theory used in civil and coastal engineering for more than a century to an arbitrary granular mass flow using the continuum mechanics approach. Using simple test cases, it is demonstrated that the above question can be answered in the affirmative way, thereby opening a new framework for the physical and mathematical modeling of granular mass flow in geophysics, whereby the effect of vertical motion is mathematically included without the need of ad hoc assumptions.

  17. Numerical Simulation of 3-D Supersonic Viscous Flow in an Experimental MHD Channel

    NASA Technical Reports Server (NTRS)

    Kato, Hiromasa; Tannehill, John C.; Gupta, Sumeet; Mehta, Unmeel B.

    2004-01-01

    The 3-D supersonic viscous flow in an experimental MHD channel has been numerically simulated. The experimental MHD channel is currently in operation at NASA Ames Research Center. The channel contains a nozzle section, a center section, and an accelerator section where magnetic and electric fields can be imposed on the flow. In recent tests, velocity increases of up to 40% have been achieved in the accelerator section. The flow in the channel is numerically computed using a new 3-D parabolized Navier-Stokes (PNS) algorithm that has been developed to efficiently compute MHD flows in the low magnetic Reynolds number regime. The MHD effects are modeled by introducing source terms into the PNS equations which can then be solved in a very e5uent manner. To account for upstream (elliptic) effects, the flowfield can be computed using multiple streamwise sweeps with an iterated PNS algorithm. The new algorithm has been used to compute two test cases that match the experimental conditions. In both cases, magnetic and electric fields are applied to the flow. The computed results are in good agreement with the available experimental data.

  18. 3-D segmentation of retinal blood vessels in spectral-domain OCT volumes of the optic nerve head

    NASA Astrophysics Data System (ADS)

    Lee, Kyungmoo; Abràmoff, Michael D.; Niemeijer, Meindert; Garvin, Mona K.; Sonka, Milan

    2010-03-01

    Segmentation of retinal blood vessels can provide important information for detecting and tracking retinal vascular diseases including diabetic retinopathy, arterial hypertension, arteriosclerosis and retinopathy of prematurity (ROP). Many studies on 2-D segmentation of retinal blood vessels from a variety of medical images have been performed. However, 3-D segmentation of retinal blood vessels from spectral-domain optical coherence tomography (OCT) volumes, which is capable of providing geometrically accurate vessel models, to the best of our knowledge, has not been previously studied. The purpose of this study is to develop and evaluate a method that can automatically detect 3-D retinal blood vessels from spectral-domain OCT scans centered on the optic nerve head (ONH). The proposed method utilized a fast multiscale 3-D graph search to segment retinal surfaces as well as a triangular mesh-based 3-D graph search to detect retinal blood vessels. An experiment on 30 ONH-centered OCT scans (15 right eye scans and 15 left eye scans) from 15 subjects was performed, and the mean unsigned error in 3-D of the computer segmentations compared with the independent standard obtained from a retinal specialist was 3.4 +/- 2.5 voxels (0.10 +/- 0.07 mm).

  19. Variational formulation of hybrid problems for fully 3-D transonic flow with shocks in rotor

    NASA Technical Reports Server (NTRS)

    Liu, Gao-Lian

    1991-01-01

    Based on previous research, the unified variable domain variational theory of hybrid problems for rotor flow is extended to fully 3-D transonic rotor flow with shocks, unifying and generalizing the direct and inverse problems. Three variational principles (VP) families were established. All unknown boundaries and flow discontinuities (such as shocks, free trailing vortex sheets) are successfully handled via functional variations with variable domain, converting almost all boundary and interface conditions, including the Rankine Hugoniot shock relations, into natural ones. This theory provides a series of novel ways for blade design or modification and a rigorous theoretical basis for finite element applications and also constitutes an important part of the optimal design theory of rotor bladings. Numerical solutions to subsonic flow by finite elements with self-adapting nodes given in Refs., show good agreement with experimental results.

  20. 3D-PTV measurement of the phototactic movement of algae in shear flow

    NASA Astrophysics Data System (ADS)

    Maeda, Tatsuyuki; Ishikawa, Takuji; Ueno, Hironori; Numayama-Tsuruta, Keiko; Imai, Yosuke; Yamaguchi, Takami

    2012-11-01

    Recently, swimming motion of algae cells is researched actively, because algae fuel is one of the hottest topic in engineering. It is known that algae swim toward the light for photosynthesis however, the effect of a background flow on the unidirectional swimming is unclear. In this study, we used Volvox as a model alga and placed them in a simple shear flow with or without light stimulus. The shear flow was generated by moving two flat sheets in the opposite direction tangentially. A red LED light (wave length 660 nm) was used as an observation light source, and a white LED light was used to stimulate cells for the phototaxis. The trajectories of individual cells were measured by a 3D-PTV system, consists of a pair of high-speed camera with macro lenses. The results were analyzed to understand the effect of the background shear flow on the phototaxis of cells.

  1. Incorporating preferential flow into a 3D model of a forested headwater catchment

    NASA Astrophysics Data System (ADS)

    Glaser, Barbara; Jackisch, Conrad; Hopp, Luisa; Pfister, Laurent; Klaus, Julian

    2016-04-01

    Preferential flow plays an important role for water flow and solute transport. The inclusion of preferential flow, for example with dual porosity or dual permeability approaches, is a common feature in transport simulations at the plot scale. But at hillslope and catchment scales, incorporation of macropore and fracture flow into distributed hydrologic 3D models is rare, often due to limited data availability for model parameterisation. In this study, we incorporated preferential flow into an existing 3D integrated surface subsurface hydrologic model (HydroGeoSphere) of a headwater region (6 ha) of the forested Weierbach catchment in western Luxembourg. Our model philosophy was a strong link between measured data and the model setup. The model setup we used previously had been parameterised and validated based on various field data. But existing macropores and fractures had not been considered in this initial model setup. The multi-criteria validation revealed a good model performance but also suggested potential for further improvement by incorporating preferential flow as additional process. In order to pursue the data driven model philosophy for the implementation of preferential flow, we analysed the results of plot scale bromide sprinkling and infiltration experiments carried out in the vicinity of the Weierbach catchment. Three 1 sqm plots were sprinkled for one hour and excavated one day later for bromide depth profile sampling. We simulated these sprinkling experiments at the soil column scale, using the parameterisation of the base headwater model extended by a second permeability domain. Representing the bromide depth profiles was successful without changing this initial parameterisation. Moreover, to explain the variability between the three bromide depth profiles it was sufficient to adapt the dual permeability properties, indicating the spatial heterogeneity of preferential flow. Subsequently, we incorporated the dual permeability simulation in the

  2. 3-D trajectory model for MDT using micro-spheres implanted within large blood vessels

    NASA Astrophysics Data System (ADS)

    Choomphon-anomakhun, Natthaphon; Natenapit, Mayuree

    2016-09-01

    Implant assisted magnetic drug targeting (IA-MDT) using ferromagnetic spherical targets implanted within large blood vessels and subjected to a uniform externally applied magnetic field (H0) has been investigated and reported for the first time. The capture areas (As) of magnetic drug carrier particles (MDCPs) were determined from the analysis of particle trajectories simulated from equations of motion. Then, the effects of various parameters, such as types of ferromagnetic materials in the targets and MDCPs, blood flow rates, mass fraction of the ferromagnetic material in the MDCPs, average radii of MDCPs (Rp) and the strength of H0 on the As were obtained. Furthermore, the effects of saturation magnetization of the ferromagnetic materials in the MDCPs and within the targets on the As were analyzed. After this, the suitable strengths of H0 and Rp for IA-MDT designs were reported. Dimensionless As, ranging from 2 to 7, was obtained with Rp ranging from 500 to 2500 nm, μ0H0 less than 0.8 T and a blood flow rate of 0.1 m s-1. The target-MDCP materials considered are iron-iron, iron-magnetite and SS409-magnetite, respectively.

  3. 3D imaging of particle-scale rotational motion in cyclically driven granular flows

    NASA Astrophysics Data System (ADS)

    Harrington, Matt; Powers, Dylan; Cooper, Eric; Losert, Wolfgang

    Recent experimental advances have enabled three-dimensional (3D) imaging of motion, structure, and failure within granular systems. 3D imaging allows researchers to directly characterize bulk behaviors that arise from particle- and meso-scale features. For instance, segregation of a bidisperse system of spheres under cyclic shear can originate from microscopic irreversibilities and the development of convective secondary flows. Rotational motion and frictional rotational coupling, meanwhile, have been less explored in such experimental 3D systems, especially under cyclic forcing. In particular, relative amounts of sliding and/or rolling between pairs of contacting grains could influence the reversibility of both trajectories, in terms of both position and orientation. In this work, we apply the Refractive Index Matched Scanning technique to a granular system that is cyclically driven and measure both translational and rotational motion of individual grains. We relate measured rotational motion to resulting shear bands and convective flows, further indicating the degree to which pairs and neighborhoods of grains collectively rotate.

  4. Slip flow through a converging microchannel: experiments and 3D simulations

    NASA Astrophysics Data System (ADS)

    Varade, Vijay; Agrawal, Amit; Pradeep, A. M.

    2015-02-01

    An experimental and 3D numerical study of gaseous slip flow through a converging microchannel is presented in this paper. The measurements reported are with nitrogen gas flowing through the microchannel with convergence angles (4°, 8° and 12°), hydraulic diameters (118, 147 and 177 µm) and lengths (10, 20 and 30 mm). The measurements cover the entire slip flow regime and a part of the continuum and transition regimes (the Knudsen number is between 0.0004 and 0.14); the flow is laminar (the Reynolds number is between 0.5 and 1015). The static pressure drop is measured for various mass flow rates. The overall pressure drop increases with a decrease in the convergence angle and has a relatively large contribution of the viscous component. The numerical solutions of the Navier-Stokes equations with Maxwell’s slip boundary condition explore two different flow behaviors: uniform centerline velocity with linear pressure variation in the initial and the middle part of the microchannel and flow acceleration with nonlinear pressure variation in the last part of the microchannel. The centerline velocity and the wall shear stress increase with a decrease in the convergence angle. The concept of a characteristic length scale for a converging microchannel is also explored. The location of the characteristic length is a function of the Knudsen number and approaches the microchannel outlet with rarefaction. These results on gaseous slip flow through converging microchannels are observed to be considerably different than continuum flow.

  5. Local Control of Blood Flow

    ERIC Educational Resources Information Center

    Clifford, Philip S.

    2011-01-01

    Organ blood flow is determined by perfusion pressure and vasomotor tone in the resistance vessels of the organ. Local factors that regulate vasomotor tone include myogenic and metabolic autoregulation, flow-mediated and conducted responses, and vasoactive substances released from red blood cells. The relative importance of each of these factors…

  6. Intrathoracic tumour motion estimation from CT imaging using the 3D optical flow method

    NASA Astrophysics Data System (ADS)

    Guerrero, Thomas; Zhang, Geoffrey; Huang, Tzung-Chi; Lin, Kang-Ping

    2004-09-01

    The purpose of this work was to develop and validate an automated method for intrathoracic tumour motion estimation from breath-hold computed tomography (BH CT) imaging using the three-dimensional optical flow method (3D OFM). A modified 3D OFM algorithm provided 3D displacement vectors for each voxel which were used to map tumour voxels on expiration BH CT onto inspiration BH CT images. A thoracic phantom and simulated expiration/inspiration BH CT pairs were used for validation. The 3D OFM was applied to the measured inspiration and expiration BH CT images from one lung cancer and one oesophageal cancer patient. The resulting displacements were plotted in histogram format and analysed to provide insight regarding the tumour motion. The phantom tumour displacement was measured as 1.20 and 2.40 cm with full-width at tenth maximum (FWTM) for the distribution of displacement estimates of 0.008 and 0.006 cm, respectively. The maximum error of any single voxel's motion estimate was 1.1 mm along the z-dimension or approximately one-third of the z-dimension voxel size. The simulated BH CT pairs revealed an rms error of less than 0.25 mm. The displacement of the oesophageal tumours was nonuniform and up to 1.4 cm, this was a new finding. A lung tumour maximum displacement of 2.4 cm was found in the case evaluated. In conclusion, 3D OFM provided an accurate estimation of intrathoracic tumour motion, with estimated errors less than the voxel dimension in a simulated motion phantom study. Surprisingly, oesophageal tumour motion was large and nonuniform, with greatest motion occurring at the gastro-oesophageal junction. Presented at The IASTED Second International Conference on Biomedical Engineering (BioMED 2004), Innsbruck, Austria, 16-18 February 2004.

  7. 3D FEM Geometry and Material Flow Optimization of Porthole-Die Extrusion

    SciTech Connect

    Ceretti, Elisabetta; Mazzoni, Luca; Giardini, Claudio

    2007-05-17

    The aim of this work is to design and to improve the geometry of a porthole-die for the production of aluminum components by means of 3D FEM simulations. In fact, the use of finite element models will allow to investigate the effects of the die geometry (webs, extrusion cavity) on the material flow and on the stresses acting on the die so to reduce the die wear and to improve the tool life. The software used to perform the simulations was a commercial FEM code, Deform 3D. The technological data introduced in the FE model have been furnished by METRA S.p.A. Company, partner in this research. The results obtained have been considered valid and helpful by the Company for building a new optimized extrusion porthole-die.

  8. Assessment of left and right atrial 3D hemodynamics in patients with atrial fibrillation: a 4D flow MRI study.

    PubMed

    Markl, Michael; Carr, Maria; Ng, Jason; Lee, Daniel C; Jarvis, Kelly; Carr, James; Goldberger, Jeffrey J

    2016-05-01

    Atrial fibrillation (AF) is associated with embolic stroke due to thrombus formation in the left atrium (LA). Based on the relationship of atrial stasis to thromboembolism and the marked disparity in pulmonary versus systemic thromboembolism in AF, we tested the hypothesis that flow velocity distributions in the left (LA) versus right atrium (RA) in patients with would demonstrate increased stasis. Whole heart 4D flow MRI was performed in 62 AF patients (n = 33 in sinus rhythm during imaging, n = 29 with persistent AF) and 8 controls for the assessment of in vivo atrial 3D blood flow. 3D segmentation of the LA and RA geometry and normalized velocity histograms assessed atrial velocity distribution and stasis (% of atrial velocities <0.2 m/s). Atrial hemodynamics were similar for RA and LA and significantly correlated (mean velocity: r = 0.64; stasis: r = 0.55, p < 0.001). RA and LA mean and median velocities were lower in AF patients by 15-33 % and stasis was elevated by 11-19 % compared to controls. There was high inter-individual variability in LA/RA mean velocity ratio (range 0.5-1.8) and LA/RA stasis ratio (range 0.7-1.7). Patients with a history of AF and in sinus rhythm showed most pronounced differences in atrial flow (reduced mean velocities, higher stasis in the LA). While there is no systematic difference in LA versus RA flow velocity profiles, high variability was noted. Further delineation of patient specific factors and/or regional atrial effects on the LA and RA flow velocity profiles, as well as other factors such as differences in procoagulant factors, may explain the more prevalent systemic versus pulmonary thromboembolism in patients with AF. PMID:26820740

  9. Calcium signaling in response to fluid flow by chondrocytes in 3D alginate culture.

    PubMed

    Degala, Satish; Williams, Rebecca; Zipfel, Warren; Bonassar, Lawrence J

    2012-05-01

    Quantifying the effects of mechanical loading on the metabolic response of chondrocytes is difficult due to complicated structure of cartilage ECM and the coupled nature of the mechanical stimuli presented to the cells. In this study we describe the effects of fluid flow, particularly hydrostatic pressure and wall shear stress, on the Ca(2+) signaling response of bovine articular chondrocytes in 3D culture. Using well-established alginate hydrogel system to maintain spherical chondrocyte morphology, we altered solid volume fraction to change scaffold mechanics. Fluid velocities in the bulk of the scaffolds were directly measured via an optical technique and scaffold permeability and aggregate modulus was characterized to quantify the mechanical stimuli presented to cells. Ca(2+) signaling response to direct perfusion of chondrocyte-seeded scaffolds increased monotonically with flow rate and was found more directly dependent on fluid velocity rather than shear stress or hydrostatic pressure. Chondrocytes in alginate scaffolds responded to fluid flow at velocities and shear stresses 2-3 orders of magnitude lower than seen in previous monolayer studies. Our data suggest that flow-induced Ca(2+) signaling response of chondrocytes in alginate culture may be due to mechanical signaling pathways, which is influenced by the 3D nature of cell shape.

  10. Cauchy's almost forgotten Lagrangian formulation of the Euler equation for 3D incompressible flow

    NASA Astrophysics Data System (ADS)

    Frisch, Uriel; Villone, Barbara

    2014-09-01

    Two prized papers, one by Augustin Cauchy in 1815, presented to the French Academy and the other by Hermann Hankel in 1861, presented to Göttingen University, contain major discoveries on vorticity dynamics whose impact is now quickly increasing. Cauchy found a Lagrangian formulation of 3D ideal incompressible flow in terms of three invariants that generalize to three dimensions the now well-known law of conservation of vorticity along fluid particle trajectories for two-dimensional flow. This has very recently been used to prove analyticity in time of fluid particle trajectories for 3D incompressible Euler flow and can be extended to compressible flow, in particular to cosmological dark matter. Hankel showed that Cauchy's formulation gives a very simple Lagrangian derivation of the Helmholtz vorticity-flux invariants and, in the middle of the proof, derived an intermediate result which is the conservation of the circulation of the velocity around a closed contour moving with the fluid. This circulation theorem was to be rediscovered independently by William Thomson (Kelvin) in 1869. Cauchy's invariants were only occasionally cited in the 19th century - besides Hankel, foremost by George Stokes and Maurice Lévy - and even less so in the 20th until they were rediscovered via Emmy Noether's theorem in the late 1960, but reattributed to Cauchy only at the end of the 20th century by Russian scientists.

  11. A 3-D nonisothermal flow simulation and pulling force model for injection pultrusion processes

    NASA Astrophysics Data System (ADS)

    Mustafa, Ibrahim

    1998-12-01

    Injected Pultrusion (IP) is an efficient way of producing high quality, low cost, high volume and constant cross-section polymeric composites. This process has been developed recently, and the efforts to optimize it are still underway. This work is related to the development of a 3-D non-isothermal flow model for the IP processes. The governing equations for transport of mass, momentum and, energy are formulated by using a local volume averaging approach, and the Finite Element/Control Volume method is used to solve the system of equations numerically. The chemical species balance equation is solved in the Lagrangian frame of reference whereas the energy equation is solved using Galerkin, SU (Streamline Upwind), and SUPG (Streamline Upwind Petrov Galerkin) approaches. By varying degrees of freedom and the flow rates of the resin, it is shown that at high Peclet numbers the SUPG formulation performs better than the SU and the Galerkin methods in all cases. The 3-D model predictions for degree of cure and temperature are compared with a one dimensional analytical solution and the results are found satisfactory. Moreover, by varying the Brinkman Number, it is shown that the effect of viscous dissipation is insignificant. The 3-D flow simulations have been carried out for both thin and thick parts and the results are compared with the 2-D model. It is shown that for thick parts 2-D simulations render erroneous results. The effect of changing permeability on the flow fronts is also addressed. The effect of increasing taper angle on the model prediction is also investigated. A parametric study is conducted to isolate optimum conditions for both isothermal and non-isothermal cases using a straight rectangular die and a die with a tapered inlet. Finally, a simple pulling force model is developed and the pulling force required to pull the carbon-epoxy fiber resin system is estimated for dies of varying tapered inlet.

  12. North Cascadia heat flux and fluid flow from gas hydrates: Modeling 3-D topographic effects

    NASA Astrophysics Data System (ADS)

    Li, Hong-lin; He, Tao; Spence, George D.

    2014-01-01

    The bottom-simulating reflector (BSR) of gas hydrate is well imaged from two perpendicular seismic grids in the region of a large carbonate mound, informally called Cucumber Ridge off Vancouver Island. We use a new method to calculate 3-D heat flow map from the BSR depths, in which we incorporate 3-D topographic corrections after calibrated by the drilling results from nearby (Integrated) Ocean Drilling Program Site 889 and Site U1327. We then estimate the associated fluid flow by relating it to the topographically corrected heat flux anomalies. In the midslope region, a heat flux anomaly of 1 mW/m2 can be associated with an approximate focused fluid flow rate of 0.09 mm/yr. Around Cucumber Ridge, high rates of focused fluid flow were observed at steep slopes with values more than double the average regional diffusive fluid discharge rate of 0.56 mm/yr. As well, in some areas of relatively flat seafloor, the focused fluid flow rates still exceeded 0.5 mm/yr. On the seismic lines the regions of focused fluid flow were commonly associated with seismic blanking zones above the BSR and sometimes with strong reflectors below the BSR, indicating that the faults/fractures provide high-permeability pathways for fluids to carry methane from BSR depths to the seafloor. These high fluid flow regions cover mostly the western portion of our area with gas hydrate concentration estimations of ~6% based on empirical correlations from Hydrate Ridge in south off Oregon, significantly higher than previously recognized values of ~2.5% in the eastern portion determined from Site U1327.

  13. Predictions of bubbly flows in vertical pipes using two-fluid models in CFDS-FLOW3D code

    SciTech Connect

    Banas, A.O.; Carver, M.B.; Unrau, D.

    1995-09-01

    This paper reports the results of a preliminary study exploring the performance of two sets of two-fluid closure relationships applied to the simulation of turbulent air-water bubbly upflows through vertical pipes. Predictions obtained with the default CFDS-FLOW3D model for dispersed flows were compared with the predictions of a new model (based on the work of Lee), and with the experimental data of Liu. The new model, implemented in the CFDS-FLOW3D code, included additional source terms in the {open_quotes}standard{close_quotes} {kappa}-{epsilon} transport equations for the liquid phase, as well as modified model coefficients and wall functions. All simulations were carried out in a 2-D axisymmetric format, collapsing the general multifluid framework of CFDS-FLOW3D to the two-fluid (air-water) case. The newly implemented model consistently improved predictions of radial-velocity profiles of both phases, but failed to accurately reproduce the experimental phase-distribution data. This shortcoming was traced to the neglect of anisotropic effects in the modelling of liquid-phase turbulence. In this sense, the present investigation should be considered as the first step toward the ultimate goal of developing a theoretically sound and universal CFD-type two-fluid model for bubbly flows in channels.

  14. A Computational Model for Suspended Large Rigid Bodies in 3D Unsteady Viscous Flows

    NASA Astrophysics Data System (ADS)

    Xiao, Feng

    1999-11-01

    A 3D numerical model for computing large rigid objects suspended in fluid flow has been developed. Rather than calculating the surface pressure upon the solid body, we evaluate the net force and torque based on a volume force formulation. The total effective force is obtained by summing up the forces at the Eulerian grids occupied by the rigid body. The effects of the moving bodies are coupled to the fluid flow by imposing the velocity field of the bodies to the fluid. A Poisson equation is used to compute the pressure over the whole domain. The objects are identified by color functions and calculated by the PPM scheme and a tangent function transformation which scales the transition region of the computed interface to a compact thickness. The model is then implemented on a parallel computer of distributed memory and validated with Stokes and low Reynolds number flows.

  15. The 3-D CFD modeling of gas turbine combustor-integral bleed flow interaction

    NASA Technical Reports Server (NTRS)

    Chen, D. Y.; Reynolds, R. S.

    1993-01-01

    An advanced 3-D Computational Fluid Dynamics (CFD) model was developed to analyze the flow interaction between a gas turbine combustor and an integral bleed plenum. In this model, the elliptic governing equations of continuity, momentum and the k-e turbulence model were solved on a boundary-fitted, curvilinear, orthogonal grid system. The model was first validated against test data from public literature and then applied to a gas turbine combustor with integral bleed. The model predictions agreed well with data from combustor rig testing. The model predictions also indicated strong flow interaction between the combustor and the integral bleed. Integral bleed flow distribution was found to have a great effect on the pressure distribution around the gas turbine combustor.

  16. Flow control on a 3D backward facing ramp by pulsed jets

    NASA Astrophysics Data System (ADS)

    Joseph, Pierric; Bortolus, Dorian; Grasso, Francesco

    2014-06-01

    This paper presents an experimental study of flow separation control over a 3D backward facing ramp by means of pulsed jets. Such geometry has been selected to reproduce flow phenomena of interest for the automotive industry. The base flow has been characterised using PIV and pressure measurements. The results show that the classical notchback topology is correctly reproduced. A control system based on magnetic valves has been used to produce the pulsed jets whose properties have been characterised by hot wire anemometry. In order to shed some light on the role of the different parameters affecting the suppression of the slant recirculation area, a parametric study has been carried out by varying the frequency and the momentum coefficient of the jets for several Reynolds numbers. xml:lang="fr"

  17. Numerical simulation of unsteady flow characteristics for cavitation around a 3-D hydrofoil

    NASA Astrophysics Data System (ADS)

    Ahn, S. H.; Xiao, Y. X.; Wang, Z. W.

    2015-01-01

    At present it is possible to predict more accurately by various numerical methods established for cavitation simulation around a hydrofoil. However, for the solution of the complex unsteady cavity flow, it is still marginal. In this paper, numerical method is adopted to simulate cavitation around 3-D NACA0015 hydrofoil with homogeneous two-phase flow calculation using commercial code CFX-solver with two turbulence models, the standard RNG k-epsilon turbulence model and the modified RNG k-epsilon turbulence model respectively. First, pressure coefficient for non-cavitating flow, time averaged values of unsteady cavity flow around a hydrofoil are verified to simulate more closely to an actual cavity flow. And then frequency analysis is performed with Fast Fourier Transform. The results show that the calculation results with modified RNG k-epsilon turbulence model agree with experimental results in terms of mean cavity length and pressure drop, but the unsteady flow characteristics of oscillating cavitation still deviate slightly in terms of unsteady cavity flow.

  18. Mimicking Natural Laminar to Turbulent Flow Transition: A Systematic CFD Study Using PAB3D

    NASA Technical Reports Server (NTRS)

    Pao, S. Paul; Abdol-Hamid, Khaled S.

    2005-01-01

    For applied aerodynamic computations using a general purpose Navier-Stokes code, the common practice of treating laminar to turbulent flow transition over a non-slip surface is somewhat arbitrary by either treating the entire flow as turbulent or forcing the flow to undergo transition at given trip locations in the computational domain. In this study, the possibility of using the PAB3D code, standard k-epsilon turbulence model, and the Girimaji explicit algebraic stresses model to mimic natural laminar to turbulent flow transition was explored. The sensitivity of flow transition with respect to two limiters in the standard k-epsilon turbulence model was examined using a flat plate and a 6:1 aspect ratio prolate spheroid for our computations. For the flat plate, a systematic dependence of transition Reynolds number on background turbulence intensity was found. For the prolate spheroid, the transition patterns in the three-dimensional boundary layer at different flow conditions were sensitive to the free stream turbulence viscosity limit, the reference Reynolds number and the angle of attack, but not to background turbulence intensity below a certain threshold value. The computed results showed encouraging agreements with the experimental measurements at the corresponding geometry and flow conditions.

  19. Reconstruction and Visualization of Coordinated 3D Cell Migration Based on Optical Flow.

    PubMed

    Kappe, Christopher P; Schütz, Lucas; Gunther, Stefan; Hufnagel, Lars; Lemke, Steffen; Leitte, Heike

    2016-01-01

    Animal development is marked by the repeated reorganization of cells and cell populations, which ultimately determine form and shape of the growing organism. One of the central questions in developmental biology is to understand precisely how cells reorganize, as well as how and to what extent this reorganization is coordinated. While modern microscopes can record video data for every cell during animal development in 3D+t, analyzing these videos remains a major challenge: reconstruction of comprehensive cell tracks turned out to be very demanding especially with decreasing data quality and increasing cell densities. In this paper, we present an analysis pipeline for coordinated cellular motions in developing embryos based on the optical flow of a series of 3D images. We use numerical integration to reconstruct cellular long-term motions in the optical flow of the video, we take care of data validation, and we derive a LIC-based, dense flow visualization for the resulting pathlines. This approach allows us to handle low video quality such as noisy data or poorly separated cells, and it allows the biologists to get a comprehensive understanding of their data by capturing dynamic growth processes in stills. We validate our methods using three videos of growing fruit fly embryos.

  20. Simulation of the 3D viscoelastic free surface flow by a parallel corrected particle scheme

    NASA Astrophysics Data System (ADS)

    Jin-Lian, Ren; Tao, Jiang

    2016-02-01

    In this work, the behavior of the three-dimensional (3D) jet coiling based on the viscoelastic Oldroyd-B model is investigated by a corrected particle scheme, which is named the smoothed particle hydrodynamics with corrected symmetric kernel gradient and shifting particle technique (SPH_CS_SP) method. The accuracy and stability of SPH_CS_SP method is first tested by solving Poiseuille flow and Taylor-Green flow. Then the capacity for the SPH_CS_SP method to solve the viscoelastic fluid is verified by the polymer flow through a periodic array of cylinders. Moreover, the convergence of the SPH_CS_SP method is also investigated. Finally, the proposed method is further applied to the 3D viscoelastic jet coiling problem, and the influences of macroscopic parameters on the jet coiling are discussed. The numerical results show that the SPH_CS_SP method has higher accuracy and better stability than the traditional SPH method and other corrected SPH method, and can improve the tensile instability. Project supported by the Natural Science Foundation of Jiangsu Province, China (Grant Nos. BK20130436 and BK20150436) and the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province, China (Grant No. 15KJB110025).

  1. Slanted channel microfluidic chip for 3D fluorescence imaging of cells in flow.

    PubMed

    Jagannadh, Veerendra Kalyan; Mackenzie, Mark D; Pal, Parama; Kar, Ajoy K; Gorthi, Sai Siva

    2016-09-19

    Three-dimensional cellular imaging techniques have become indispensable tools in biological research and medical diagnostics. Conventional 3D imaging approaches employ focal stack collection to image different planes of the cell. In this work, we present the design and fabrication of a slanted channel microfluidic chip for 3D fluorescence imaging of cells in flow. The approach employs slanted microfluidic channels fabricated in glass using ultrafast laser inscription. The slanted nature of the microfluidic channels ensures that samples come into and go out of focus, as they pass through the microscope imaging field of view. This novel approach enables the collection of focal stacks in a straight-forward and automated manner, even with off-the-shelf microscopes that are not equipped with any motorized translation/rotation sample stages. The presented approach not only simplifies conventional focal stack collection, but also enhances the capabilities of a regular widefield fluorescence microscope to match the features of a sophisticated confocal microscope. We demonstrate the retrieval of sectioned slices of microspheres and cells, with the use of computational algorithms to enhance the signal-to-noise ratio (SNR) in the collected raw images. The retrieved sectioned images have been used to visualize fluorescent microspheres and bovine sperm cell nucleus in 3D while using a regular widefield fluorescence microscope. We have been able to achieve sectioning of approximately 200 slices per cell, which corresponds to a spatial translation of ∼ 15 nm per slice along the optical axis of the microscope. PMID:27661949

  2. Slanted channel microfluidic chip for 3D fluorescence imaging of cells in flow.

    PubMed

    Jagannadh, Veerendra Kalyan; Mackenzie, Mark D; Pal, Parama; Kar, Ajoy K; Gorthi, Sai Siva

    2016-09-19

    Three-dimensional cellular imaging techniques have become indispensable tools in biological research and medical diagnostics. Conventional 3D imaging approaches employ focal stack collection to image different planes of the cell. In this work, we present the design and fabrication of a slanted channel microfluidic chip for 3D fluorescence imaging of cells in flow. The approach employs slanted microfluidic channels fabricated in glass using ultrafast laser inscription. The slanted nature of the microfluidic channels ensures that samples come into and go out of focus, as they pass through the microscope imaging field of view. This novel approach enables the collection of focal stacks in a straight-forward and automated manner, even with off-the-shelf microscopes that are not equipped with any motorized translation/rotation sample stages. The presented approach not only simplifies conventional focal stack collection, but also enhances the capabilities of a regular widefield fluorescence microscope to match the features of a sophisticated confocal microscope. We demonstrate the retrieval of sectioned slices of microspheres and cells, with the use of computational algorithms to enhance the signal-to-noise ratio (SNR) in the collected raw images. The retrieved sectioned images have been used to visualize fluorescent microspheres and bovine sperm cell nucleus in 3D while using a regular widefield fluorescence microscope. We have been able to achieve sectioning of approximately 200 slices per cell, which corresponds to a spatial translation of ∼ 15 nm per slice along the optical axis of the microscope.

  3. Segmentation of bone structures in 3D CT images based on continuous max-flow optimization

    NASA Astrophysics Data System (ADS)

    Pérez-Carrasco, J. A.; Acha-Piñero, B.; Serrano, C.

    2015-03-01

    In this paper an algorithm to carry out the automatic segmentation of bone structures in 3D CT images has been implemented. Automatic segmentation of bone structures is of special interest for radiologists and surgeons to analyze bone diseases or to plan some surgical interventions. This task is very complicated as bones usually present intensities overlapping with those of surrounding tissues. This overlapping is mainly due to the composition of bones and to the presence of some diseases such as Osteoarthritis, Osteoporosis, etc. Moreover, segmentation of bone structures is a very time-consuming task due to the 3D essence of the bones. Usually, this segmentation is implemented manually or with algorithms using simple techniques such as thresholding and thus providing bad results. In this paper gray information and 3D statistical information have been combined to be used as input to a continuous max-flow algorithm. Twenty CT images have been tested and different coefficients have been computed to assess the performance of our implementation. Dice and Sensitivity values above 0.91 and 0.97 respectively were obtained. A comparison with Level Sets and thresholding techniques has been carried out and our results outperformed them in terms of accuracy.

  4. Rotary slanted single wire CTA - a useful tool for 3D flows investigations

    NASA Astrophysics Data System (ADS)

    Jonáš, P.

    2013-04-01

    The procedure is described of experimental investigation of a statistically stationary generally nonisothermal 3D flow by means of a constant temperature anemometer (CTA) using single slanted heated wire, rotary round the fixed axis. The principle of this procedure is quite clear. The change of the heated wire temperature modifies ratio of CTA sensitivities to temperature and velocity fluctuations. Turning the heated wire through a proper angle changes the sensitivity to components of the instantaneous velocity vector. Some recommendations are presented based on long time experiences, e.g. on the choice of probe, on the probe calibration, to the measurement organization and to the evaluation of results.

  5. Reactive Flow Modeling of Liquid Explosives via ALE3D/Cheetah Simulations

    SciTech Connect

    Kuo, I W; Bastea, S; Fried, L E

    2010-03-10

    We carried out reactive flow simulations of liquid explosives such as nitromethane using the hydrodynamic code ALE3D coupled with equations of state and reaction kinetics modeled by the thermochemical code Cheetah. The simulation set-up was chosen to mimic cylinder experiments. For pure unconfined nitromethane we find that the failure diameter and detonation velocity dependence on charge diameter are in agreement with available experimental results. Such simulations are likely to be useful for determining detonability and failure behavior for a wide range of experimental conditions and explosive compounds.

  6. Line relaxation methods for the solution of 2D and 3D compressible flows

    NASA Technical Reports Server (NTRS)

    Hassan, O.; Probert, E. J.; Morgan, K.; Peraire, J.

    1993-01-01

    An implicit finite element based algorithm for the compressible Navier-Stokes equations is outlined, and the solution of the resulting equation by a line relaxation on general meshes of triangles or tetrahedra is described. The problem of generating and adapting unstructured meshes for viscous flows is reexamined, and an approach for both 2D and 3D simulations is proposed. An efficient approach appears to be the use of an implicit/explicit procedure, with the implicit treatment being restricted to those regions of the mesh where viscous effects are known to be dominant. Numerical examples demonstrating the computational performance of the proposed techniques are given.

  7. Decay of the 3D viscous liquid-gas two-phase flow model with damping

    NASA Astrophysics Data System (ADS)

    Zhang, Yinghui

    2016-08-01

    We establish the optimal Lp - L2(1 ≤ p < 6/5) time decay rates of the solution to the Cauchy problem for the 3D viscous liquid-gas two-phase flow model with damping and analyse the influences of the damping on the qualitative behaviors of solution. It is observed that the fraction effect of the damping affects the dispersion of fluids and enhances the time decay rate of solution. Our method of proof consists of Hodge decomposition technique, Lp - L2 estimates for the linearized equations, and delicate energy estimates.

  8. Kinetic depth effect and optic flow--I. 3D shape from Fourier motion.

    PubMed

    Dosher, B A; Landy, M S; Sperling, G

    1989-01-01

    Fifty-three different 3D shapes were defined by sequences of 2D views (frames) of dots on a rotating 3D surface. (1) Subjects' accuracy of shape identifications dropped from over 90% to less than 10% when either the polarity of the stimulus dots was alternated from light-on-gray to dark-on-gray on successive frames or when neutral gray interframe intervals were interposed. Both manipulations interfere with motion extraction by spatio-temporal (Fourier) and gradient first-order detectors. Second-order (non-Fourier) detectors that use full-wave rectification are unaffected by alternating-polarity but disrupted by interposed gray frames. (2) To equate the accuracy of two-alternative forced-choice (2AFC) planar direction-of-motion discrimination in standard and polarity-alternated stimuli, standard contrast was reduced. 3D shape discrimination survived contrast reduction in standard stimuli whereas it failed completely with polarity-alternation even at full contrast. (3) When individual dots were permitted to remain in the image sequence for only two frames, performance showed little loss compared to standard displays where individual dots had an expected lifetime of 20 frames, showing that 3D shape identification does not require continuity of stimulus tokens. (4) Performance in all discrimination tasks is predicted (up to a monotone transformation) by considering the quality of first-order information (as given by a simple computation on Fourier power) and the number of locations at which motion information is required. Perceptual first-order analysis of optic flow is the primary substrate for structure-from-motion computations in random dot displays because only it offers sufficient quality of perceptual motion at a sufficient number of locations.

  9. Study on 3-D simulation of flow and turbidity in an oxbow lake in tidal compartment

    NASA Astrophysics Data System (ADS)

    Yokoyama, H.; Momonoe, H.; Hamamoto, S.

    2010-12-01

    We aimed to make flow and turbidity simulation model for an oxbow lake in tidal compartment. The oxbow has two bottle-necks and inflow river from urban district. Bed topography of the oxbow is former meandering channel of large-basin river. Therefore characteristic of flow and water quality is complex. First, field observation was conducted to clarify the characteristics of flow and water quality in the oxbow. From observation results, flow and resuspension phenomena in the oxbow were affected by wind and tide, and the balance of the two factors changed longitudinally. Next, we built 3-D simulation model of flow which took account of the field observation results. In order to investigate effective water quality improvement, we set some test cases: condition of wind, inflow river were changed. From the simulation results, tide was the most important factor, however at the upper part of the oxbow, where the tidal power seemed to be weaker, flow and turbidity were clearly affected by the wind.

  10. Parallel 3D computation of unsteady wake flows with complex geometries and fluid-structure interactions

    NASA Astrophysics Data System (ADS)

    Osawa, Yasuo

    New powerful parallel computational tools are developed for 3D simulation of unsteady wake flows with complex geometries and fluid-structure interactions. The base method for flow simulation is a finite element formulation for the Navier-Stokes equations. The finite element formulation is based on the streamline-upwind/Petrov-Galerkin (SUPG) and pressure-stabilizing/Petrov-Galerkin (PSPG) techniques. These stabilization techniques facilitate simulation of flows with high Reynolds numbers, and allow us to use equal-order interpolation functions for velocity and pressure without generating numerical oscillations. A multi-domain computational method is developed to simulate wake flow both in the near and far downstream. The formulations lead to coupled nonlinear equation systems which are solved, at every time step, with the Newton-Raphson method. The overall formulation and solution techniques are implemented on parallel platforms such as the CRAY T3E and SGI PowerChallenge. Two phases of vortex shedding for flow past a cylinder is simulated to verify the accuracy of this method. The Enhanced-Discretization Interface Capturing Technique (EDICT) is utilized to simulate wake flow accurately. Fluid-structure coupling solution method based on the Deforming-Spatial-Domain/Stabilized Space-Time (DSD/SST) formulation is applied to simulate a parachute behavior in the unsteady wake.

  11. Improved Algorithms and Methods for Solving Strongly Variable-Viscosity 3D Stokes flow and Strongly Variable Permeability 3D D’Arcy flow on a Parallel Computer

    NASA Astrophysics Data System (ADS)

    Morgan, J. P.; Hasenclever, J.; Shi, C.

    2009-12-01

    Computational studies of mantle convection face large challenges to obtain fast and accurate solutions for variable viscosity 3d flow. Recently we have been using parallel (MPI-based) MATLAB to more thoroughly explore possible pitfalls and algorithmic improvements to current ‘best-practice’ variable viscosity Stokes and D’Arcy flow solvers. Here we focus on study of finite-element solvers based on a decomposition of the equations for incompressible Stokes flow: Ku + Gp = f and G’u = 0 (K-velocity stiffness matrix, G-discretized gradient operator, G’=transpose(G)-discretized divergence operator) into a single equation for pressure Sp==G’K^-1Gp =G’K^-1f, in which the velocity is also updated as part of each pressure iteration. The outer pressure iteration is solved with preconditioned conjugate gradients (CG) (Maday and Patera, 1989), with a multigrid-preconditioned CG solver for the z=K^-1 (Gq) step of each pressure iteration. One fairly well-known pitfall (Fortin, 1985) is that constant-pressure elements can generate a spurious non-zero flow under a constant body force within non-rectangular geometries. We found a new pitfall when using an iterative method to solve the Kz=y operation in evaluating each G’K^-1Gq product -- even if the residual of the outer pressure equation converges to zero, the discrete divergence of this equation does not correspondingly converge; the error in the incompressibility depends on roughly the square of the tolerance used to solve each Kz=y velocity-like subproblem. Our current best recipe is: (1) Use flexible CG (cf. Notay, 2001) to solve the outer pressure problem. This is analogous to GMRES for a symmetric positive definite problem. It allows use of numerically unsymmetric and/or inexact preconditioners with CG. (2) In this outer-iteration, use an ‘alpha-bar’ technique to find the appropriate magnitude alpha to change the solution in each search direction. This improvement allows a similar iterative tolerance of

  12. Endovascular blood flow measurement system

    NASA Astrophysics Data System (ADS)

    Khe, A. K.; Cherevko, A. A.; Chupakhin, A. P.; Krivoshapkin, A. L.; Orlov, K. Yu

    2016-06-01

    In this paper an endovascular measurement system used for intraoperative cerebral blood flow monitoring is described. The system is based on a Volcano ComboMap Pressure and Flow System extended with analogue-to-digital converter and PC laptop. A series of measurements performed in patients with cerebrovascular pathologies allows us to introduce “velocity-pressure” and “flow rate-energy flow rate” diagrams as important characteristics of the blood flow. The measurement system presented here can be used as an additional instrument in neurosurgery for assessment and monitoring of the operation procedure. Clinical data obtained with the system are used for construction of mathematical models and patient-specific simulations. The monitoring of the blood flow parameters during endovascular interventions was approved by the Ethics Committee at the Meshalkin Novosibirsk Research Institute of Circulation Pathology and included in certain surgical protocols for pre-, intra- and postoperative examinations.

  13. 3D High-Resolution Seismic Imaging of Fluid Flow Anomalies on the Norwegian Continental Shelf

    NASA Astrophysics Data System (ADS)

    Planke, S.; Eriksen, F. N.; Eriksen, O. K.; Myklebust, R.; Stokke, H. H.

    2015-12-01

    Fluid flow anomalies are common on the Norwegian Continental Shelf. Such features are imaged by multiple P-Cable high resolution seismic 2D lines and 3D cubes in the Norwegian Barents Sea. P-Cable is a high resolution 3D seismic system consisting of multiple streamers attached to a cross cable that is towed perpendicular to the vessels steaming direction. The short offset, high frequency source and closely spaced streamers facilitates for excellent vertical and horizontal resolution that provides key information for understanding the sub-surface. Recent data have been broadband processed, and the method has proven to enhance the imaging of the sub-surface significantly. Barents Sea P-Cable surveys have targeted shallow fluid anomalies in the uppermost ca. 500 meters of the sub-surface. New data have been acquired in 2012, 2014 and 2015. The most recent data focus on the southeast part of the Norwegian Barents Sea where P-Cable data give a new insight into the subsurface not provided by conventional seismic data in the region. Geologically, the Barents Sea region is characterized by Paleozoic and Mesozoic siliciclastic successions overlaid in most areas by a thin cover of Cenozoic glacial sediments. Hydrocarbon-rich Jurassic and Triassic sequences are locally situated in the shallow sub-surface as a result of extensive late Cenozoic uplift and erosion. The unloading has been reported to reactivate and create new faults in addition to initiate further migration of fluids in the sub-surface (Chand et al., 2012). The presence of shallow hydrocarbon systems creates an optimal setting for imaging fluid flow anomalies with high resolution 3D seismic data. The Barents Sea P-Cable data image a range of fluid related features such as cross-cutting reflections and bright spots, chimney structures, acoustic masking, pockmarks and mud volcanoes.

  14. Brightness-compensated 3-D optical flow algorithm for monitoring cochlear motion patterns

    NASA Astrophysics Data System (ADS)

    von Tiedemann, Miriam; Fridberger, Anders; Ulfendahl, Mats; de Monvel, Jacques Boutet

    2010-09-01

    A method for three-dimensional motion analysis designed for live cell imaging by fluorescence confocal microscopy is described. The approach is based on optical flow computation and takes into account brightness variations in the image scene that are not due to motion, such as photobleaching or fluorescence variations that may reflect changes in cellular physiology. The 3-D optical flow algorithm allowed almost perfect motion estimation on noise-free artificial sequences, and performed with a relative error of <10% on noisy images typical of real experiments. The method was applied to a series of 3-D confocal image stacks from an in vitro preparation of the guinea pig cochlea. The complex motions caused by slow pressure changes in the cochlear compartments were quantified. At the surface of the hearing organ, the largest motion component was the transverse one (normal to the surface), but significant radial and longitudinal displacements were also present. The outer hair cell displayed larger radial motion at their basolateral membrane than at their apical surface. These movements reflect mechanical interactions between different cellular structures, which may be important for communicating sound-evoked vibrations to the sensory cells. A better understanding of these interactions is important for testing realistic models of cochlear mechanics.

  15. Flow-Through Stream Modeling with MODFLOW and MT3D: Certainties and Limitations.

    PubMed

    Ben Simon, Rose; Bernard, Stéphane; Meurville, Charles; Rebour, Vincent

    2015-01-01

    This paper aims to assess MODFLOW and MT3D capabilities for simulating the spread of contaminants from a river exhibiting an unusual relationship with an alluvial aquifer, with the groundwater head higher than the river head on one side and lower on the other (flow-through stream). A series of simulation tests is conducted using a simple hypothetical model so as to characterize and quantify these limitations. Simulation results show that the expected contaminant spread could be achieved with a specific configuration composed of two sets of parameters: (1) modeled object parameters (hydraulic groundwater gradient, hydraulic conductivity values of aquifer and streambed), and (2) modeling parameters (vertical discretization of aquifer, horizontal refinement of stream modeled with River [RIV] package). The influence of these various parameters on simulation results is investigated, and potential complications and errors are identified. Contaminant spread from stream to aquifer is not always reproduced by MT3D due to the RIV package's inability to simulate lateral exchange fluxes between stream and aquifer. This paper identifies the need for a MODFLOW streamflow package allowing lateral stream-aquifer interactions and streamflow routine calculations. Such developments could be of particular interest for modeling contaminated flow-through streams.

  16. 3D conformation of a flexible fiber in a turbulent flow

    NASA Astrophysics Data System (ADS)

    Verhille, Gautier; Bartoli, Adrien

    2016-07-01

    A growing number of studies is devoted to anisotropic particles in turbulent flows. In most cases, the particles are assumed to be rigid and their deformations are neglected. We present an adaptation of classical computer vision tools to reconstruct from two different images the 3D conformation of a fiber distorted by the turbulent fluctuations in a von Kármán flow. This technique allows us notably to characterize the fiber deformation by computing the correlation function of the orientation of the tangent vector. This function allows us to tackle the analogy between polymers and flexible fibers proposed by Brouzet et al. (Phys Rev Lett 112(7):074501, 2014). We show that this function depends on an elastic length ℓ _e which characterizes the particle flexibility, as is the case for polymers, but also on the fiber length L, contrary to polymers.

  17. Measuring the orientation and rotation rate of 3D printed particles in turbulent flow

    NASA Astrophysics Data System (ADS)

    Voth, Greg; Marcus, Guy G.; Parsa, Shima; Kramel, Stefan; Ni, Rui; Cole, Brendan

    2014-11-01

    The orientation distribution and rotations of anisotropic particles plays a key role in many applications ranging from icy clouds to papermaking and drag reduction in pipe flow. Experimental access to time resolved orientations of anisotropic particles has not been easy to achieve. We have found that 3D printing technology can be used to fabricate a wide range of particle shapes with smallest dimension down to 300 μm. So far we have studied rods, crosses, jacks, tetrads, and helical shapes. We extract the particle orientations from stereoscopic video images using a method of least squares optimization in Euler angle space. We find that in turbulence the orientation and rotation rate of many particles can be understood using a simple picture of alignment of both the vorticity and a long axis of the particle with the Lagrangian stretching direction of the flow. This research is supported by NSF Grant DMR-1208990.

  18. Measuring the orientation and rotation rate of 3D printed particles in turbulent flow

    NASA Astrophysics Data System (ADS)

    Voth, Greg; Kramel, Stefan; Cole, Brendan

    2015-03-01

    The orientation distribution and rotations of anisotropic particles plays a key role in many applications ranging from icy clouds to papermaking and drag reduction in pipe flow. Experimental access to time resolved orientations of anisotropic particles has not been easy to achieve. We have found that 3D printing technology can be used to fabricate a wide range of particle shapes with smallest dimension down to 300 ?m. So far we have studied rods, crosses, jacks, tetrads, and helical shapes. We extract the particle orientations from stereoscopic video images using a method of least squares optimization in Euler angle space. We find that in turbulence the orientation and rotation rate of many particles can be understood using a simple picture of alignment of both the vorticity and a long axis of the particle with the Lagrangian stretching direction of the flow.

  19. Decay of the 3D inviscid liquid-gas two-phase flow model

    NASA Astrophysics Data System (ADS)

    Zhang, Yinghui

    2016-06-01

    We establish the optimal {Lp-L2(1 ≤ p < 6/5)} time decay rates of the solution to the Cauchy problem for the 3D inviscid liquid-gas two-phase flow model and analyze the influences of the damping on the qualitative behaviors of solution. Compared with the viscous liquid-gas two-phase flow model (Zhang and Zhu in J Differ Equ 258:2315-2338, 2015), our results imply that the friction effect of the damping is stronger than the dissipation effect of the viscosities and enhances the decay rate of the velocity. Our proof is based on Hodge decomposition technique, the {Lp-L2} estimates for the linearized equations and an elaborate energy method.

  20. A 3-D implicit finite-volume model of shallow water flows

    NASA Astrophysics Data System (ADS)

    Wu, Weiming; Lin, Qianru

    2015-09-01

    A three-dimensional (3-D) model has been developed to simulate shallow water flows in large water bodies, such as coastal and estuarine waters. The eddy viscosity is determined using a newly modified mixing length model that uses different mixing length functions for the horizontal and vertical shear strain rates. The 3-D shallow water flow equations with the hydrostatic pressure assumption are solved using an implicit finite-volume method based on a quadtree (telescoping) rectangular mesh on the horizontal plane and the sigma coordinate in the vertical direction. The quadtree technique can locally refine the mesh around structures or in high-gradient regions by splitting a coarse cell into four child cells. The grid nodes are numbered with a one-dimensional index system that has unstructured grid feature for better grid flexibility. All the primary variables are arranged in a non-staggered grid system. Fluxes at cell faces are determined using a Rhie and Chow-type momentum interpolation, to avoid the possible spurious checkerboard oscillations caused by linear interpolation. Each of the discretized governing equations is solved iteratively using the flexible GMRES method with ILUT preconditioning, and coupling of water level and velocity among these equations is achieved by using the SIMPLEC algorithm with under-relaxation. The model has been tested in four cases, including steady flow near a spur-dyke, tidal flows in San Francisco Bay and Gironde Estuary, and wind-induced current in a flume. The calculated water levels and velocities are in good agreement with the measured values.

  1. Brain Function and Blood Flow

    ERIC Educational Resources Information Center

    Lassen, Niels A.; And Others

    1978-01-01

    Discusses the use of radioactive isotopes to graphically represent changes in the amount of blood flowing in areas of the human cerebral cortex, reflecting changes in the activity of those areas. Numerous illustrations are included. (Author/MA)

  2. Computed Tomography 3-D Imaging of the Metal Deformation Flow Path in Friction Stir Welding

    NASA Technical Reports Server (NTRS)

    Schneider, Judy; Beshears, Ronald; Nunes, Arthur C., Jr.

    2005-01-01

    In friction stir welding (FSW), a rotating threaded pin tool is inserted into a weld seam and literally stirs the edges of the seam together. To determine optimal processing parameters for producing a defect free weld, a better understanding of the resulting metal deformation flow path is required. Marker studies are the principal method of studying the metal deformation flow path around the FSW pin tool. In our study, we have used computed tomography (CT) scans to reveal the flow pattern of a lead wire embedded in a FSW weld seam. At the welding temperature of aluminum, the lead becomes molten and is carried with the macro-flow of the weld metal. By using CT images, a 3-dimensional (3D) image of the lead flow pattern can be reconstructed. CT imaging was found to be a convenient and comprehensive way of collecting and displaying tracer data. It marks an advance over previous more tedious and ambiguous radiographic/metallographic data collection methods.

  3. Determination of the optimal first-order gradient moment for flow-sensitive dephasing magnetization-prepared 3D noncontrast MR angiography.

    PubMed

    Fan, Zhaoyang; Zhou, Xiangzhi; Bi, Xiaoming; Dharmakumar, Rohan; Carr, James C; Li, Debiao

    2011-04-01

    Flow-sensitive dephasing (FSD) magnetization preparation has been developed for black-blood vessel wall MRI and noncontrast MR angiography. The first-order gradient moment, m(1) , is a measure of the flow-sensitization imparted by an FSD preparative module. Determination of the optimal m(1) for each individual is highly desirable for FSD-prepared MR angiography. This work developed a 2D m(1)-scouting method that evaluates a range of m(1) values for their effectiveness in blood signal suppression in a single scan. The feasibility of using the 2D method to predict blood signal suppression in 3D FSD-prepared imaging was validated on a flow phantom and the popliteal arteries of 5 healthy volunteers. Excellent correlation of the blood signal measurements between the 2D scouting and 3D FSD imaging was obtained. Therefore, the optimal m(1) determined from the 2D m(1)-scouting scan may be directly translated to 3D FSD-prepared imaging. In vivo studies of additional 10 healthy volunteers and 2 patients have demonstrated the proposed method can help significantly improve the signal performance of FSD MR angiography, indicating its potential to enhance diagnostic confidence. Further systematic studies in patients are warranted to evaluate its clinical value.

  4. Test Problems for Reactive Flow HE Model in the ALE3D Code and Limited Sensitivity Study

    SciTech Connect

    Gerassimenko, M.

    2000-03-01

    We document quick running test problems for a reactive flow model of HE initiation incorporated into ALE3D. A quarter percent change in projectile velocity changes the outcome from detonation to HE burn that dies down. We study the sensitivity of calculated HE behavior to several parameters of practical interest where modeling HE initiation with ALE3D.

  5. Viscous Incompressible Flow Computations for 3-D Steady and Unsteady Flows

    NASA Technical Reports Server (NTRS)

    Kwak, Dochan

    2001-01-01

    This viewgraph presentation gives an overview of viscous incompressible flow computations for three-dimensional steady and unsteady flows. Details are given on the use of computational fluid dynamics (CFD) as an engineering tool, solution methods for incompressible Navier-Stokes equations, numerical and physical characteristics of the primitive variable approach, and the role of CFD in the past and in current engineering and research applications.

  6. Blood Flow, Slip, and Viscometry

    PubMed Central

    Nubar, Yves

    1971-01-01

    The viscosity of blood, measured by the usual viscometers in which slip is not considered, is found to be flow dependent, varying markedly with shear rate, pressure gradient, and vessel diameter in the lower ranges of these factors. The study postulates, on grounds thought reasonable, that slip may be present in blood flow, as a function of the nature of the wall surfaces, shear stress at the wall, and relative cell volume (RCV) adjacent to the wall. It presumes that blood possesses a specific, flow-independent viscosity, and determines theoretically the viscosity indications of viscometers if blood slipped in the instruments. The study shows that if the slip function is of a certain plausible form, these viscosity indications would exhibit a flow dependence of much the same pattern as the actual indications supplied by the usual viscometers. The slip postulate permits, therefore, an interpretation of the “anomalous” flow behavior of blood, dispensing with the prevailing assumption of an ad hoc variability of its viscosity with flow factors. To the extent that viscometric data for blood may be representative of other non-newtonian fluids, the slip postulate may be applicable to these fluids. PMID:5573368

  7. Chaotic advection and heat transfer in two similar 2-D periodic flows and in their corresponding 3-D periodic flows

    NASA Astrophysics Data System (ADS)

    Vinsard, G.; Dufour, S.; Saatdjian, E.; Mota, J. P. B.

    2016-03-01

    Chaotic advection can effectively enhance the heat transfer rate between a boundary and fluids with high Prandtl number. These fluids are usually highly viscous and thus turbulent agitation is not a viable solution since the energy required to mix the fluid would be prohibitive. Here, we analyze previously obtained results on chaotic advection and heat transfer in two similar 2-D periodic flows and on their corresponding 3-D periodic flows when an axial velocity component is superposed. The two flows studied are the flow between eccentric rotating cylinders and the flow between confocal ellipses. For both of these flows the analysis is simplified because the Stokes equations can be solved analytically to obtain a closed form solution. For both 2-D periodic flows, we show that chaotic heat transfer is enhanced by the displacement of the saddle point location during one period. Furthermore, the enhancement by chaotic advection in the elliptical geometry is approximately double that obtained in the cylindrical geometry because there are two saddle points instead of one. We also explain why, for high eccentricity ratios, there is no heat transfer enhancement in the cylindrical geometry. When an axial velocity component is added to both of these flows so that they become 3-D, previous work has shown that there is an optimum modulation frequency for which chaotic advection and heat transfer enhancement is a maximum. Here we show that the optimum modulation frequency can be derived from results without an axial flow. We also explain by physical arguments other previously unanswered questions in the published data.

  8. The mantle wedge's transient 3-D flow regime and thermal structure

    NASA Astrophysics Data System (ADS)

    Davies, D. R.; Le Voci, G.; Goes, S.; Kramer, S. C.; Wilson, C. R.

    2016-01-01

    Arc volcanism, volatile cycling, mineralization, and continental crust formation are likely regulated by the mantle wedge's flow regime and thermal structure. Wedge flow is often assumed to follow a regular corner-flow pattern. However, studies that incorporate a hydrated rheology and thermal buoyancy predict internal small-scale-convection (SSC). Here, we systematically explore mantle-wedge dynamics in 3-D simulations. We find that longitudinal "Richter-rolls" of SSC (with trench-perpendicular axes) commonly occur if wedge hydration reduces viscosities to Pa s, although transient transverse rolls (with trench-parallel axes) can dominate at viscosities of Pa s. Rolls below the arc and back arc differ. Subarc rolls have similar trench-parallel and trench-perpendicular dimensions of 100-150 km and evolve on a 1-5 Myr time-scale. Subback-arc instabilities, on the other hand, coalesce into elongated sheets, usually with a preferential trench-perpendicular alignment, display a wavelength of 150-400 km and vary on a 5-10 Myr time scale. The modulating influence of subback-arc ridges on the subarc system increases with stronger wedge hydration, higher subduction velocity, and thicker upper plates. We find that trench-parallel averages of wedge velocities and temperature are consistent with those predicted in 2-D models. However, lithospheric thinning through SSC is somewhat enhanced in 3-D, thus expanding hydrous melting regions and shifting dehydration boundaries. Subarc Richter-rolls generate time-dependent trench-parallel temperature variations of up to K, which exceed the transient 50-100 K variations predicted in 2-D and may contribute to arc-volcano spacing and the variable seismic velocity structures imaged beneath some arcs.

  9. Inverse cascades sustained by the transfer rate of angular momentum in a 3D turbulent flow

    NASA Astrophysics Data System (ADS)

    Burguete, Javier; Lopez-Caballero, Miguel

    2013-11-01

    The existence of energy cascades as signatures of conserved magnitudes is one of the universal characteristics of turbulent flows. In this work we present the evidence of an inverse cascade in a fully developed 3D experimental turbulent flow where the conserved magnitude is the angular momentum. We analyze the behavior of a fluid in a closed cavity where two inhomogeneous and strongly turbulent flows collide in a thin region. The experimental volume is a closed cylinder (diameter of 20 cm) where two impellers rotate in opposite directions. A key characteristic of this setup the high stability of the propellers (the instantaneous fluctuations are below 0 . 1 %). We have performed PIV and LDA measurements of the velocity fields. Typical characteristics of the turbulent flow in this setup are: turbulence intensity 50 % , the Reλ = 900 , the Taylor microscale λT = 1 . 8 mm and the integral scale LI = 15 mm. The analysis of the data series reveal that below the injection scales an inverse cascade can be identified (-1/3 in time, -7/3 in space) that can be explained as the transfer of angular momentum between the diferent fluid layers. A. de la Torre, J. Burguete, Phys Rev Lett 99 (2007) 054101. M. Lopez-Caballero, J. Burguete, Phys Rev Lett 110 (2013) 124501.

  10. Simulation of a Synthetic Jet in Quiescent Air Using TLNS3D Flow Code

    NASA Technical Reports Server (NTRS)

    Vatsa, Veer N.; Turkel, Eli

    2007-01-01

    Although the actuator geometry is highly three-dimensional, the outer flowfield is nominally two-dimensional because of the high aspect ratio of the rectangular slot. For the present study, this configuration is modeled as a two-dimensional problem. A multi-block structured grid available at the CFDVAL2004 website is used as a baseline grid. The periodic motion of the diaphragm is simulated by specifying a sinusoidal velocity at the diaphragm surface with a frequency of 450 Hz, corresponding to the experimental setup. The amplitude is chosen so that the maximum Mach number at the jet exit is approximately 0.1, to replicate the experimental conditions. At the solid walls zero slip, zero injection, adiabatic temperature and zero pressure gradient conditions are imposed. In the external region, symmetry conditions are imposed on the side (vertical) boundaries and far-field conditions are imposed on the top boundary. A nominal free-stream Mach number of 0.001 is imposed in the free stream to simulate incompressible flow conditions in the TLNS3D code, which solves compressible flow equations. The code was run in unsteady (URANS) mode until the periodicity was established. The time-mean quantities were obtained by running the code for at least another 15 periods and averaging the flow quantities over these periods. The phase-locked average of flow quantities were assumed to be coincident with their values during the last full time period.

  11. Simulation of abrasive flow machining process for 2D and 3D mixture models

    NASA Astrophysics Data System (ADS)

    Dash, Rupalika; Maity, Kalipada

    2015-12-01

    Improvement of surface finish and material removal has been quite a challenge in a finishing operation such as abrasive flow machining (AFM). Factors that affect the surface finish and material removal are media viscosity, extrusion pressure, piston velocity, and particle size in abrasive flow machining process. Performing experiments for all the parameters and accurately obtaining an optimized parameter in a short time are difficult to accomplish because the operation requires a precise finish. Computational fluid dynamics (CFD) simulation was employed to accurately determine optimum parameters. In the current work, a 2D model was designed, and the flow analysis, force calculation, and material removal prediction were performed and compared with the available experimental data. Another 3D model for a swaging die finishing using AFM was simulated at different viscosities of the media to study the effects on the controlling parameters. A CFD simulation was performed by using commercially available ANSYS FLUENT. Two phases were considered for the flow analysis, and multiphase mixture model was taken into account. The fluid was considered to be a

  12. Simulation of 3D flows past hypersonic vehicles in FlowVision software

    NASA Astrophysics Data System (ADS)

    Aksenov, A. A.; Zhluktov, S. V.; Savitskiy, D. V.; Bartenev, G. Y.; Pokhilko, V. I.

    2015-11-01

    A new implicit velocity-pressure split method is discussed in the given presentation. The method implies using conservative velocities, obtained at the given time step, for integration of the momentum equation and other convection-diffusion equations. This enables simulation of super- and hypersonic flows with account of motion of solid boundaries. Calculations of known test cases performed in the FlowVision software are demonstrated. It is shown that the method allows one to carry out calculations at high Mach numbers with integration step essentially exceeding the explicit time step.

  13. Multiscale modeling of mechanosensing channels on vesicles and cell membranes in 3D constricted flows and shear flows

    NASA Astrophysics Data System (ADS)

    Peng, Zhangli; Pak, On Shun; Young, Yuan-Nan; Liu, Allen; Stone, Howard

    2015-11-01

    We investigate the gating of mechanosensing channels (Mscls) on vesicles and cell membranes under different flow conditions using a multiscale approach. At the cell level (microns), the membrane tension is calculated using a 3D two-component whole-cell membrane model based on dissipative particle dynamics (DPD), including the cortex cytoskeleton and its interactions with the lipid bilayer. At the Mscl level (nanometers), we predict the relation between channel gating and the membrane tension obtained from a cell-level model using a semi-analytical model based on the bilayer hydrophobic mismatch energy. We systematically study the gating of Mscls of vesicles and cell membranes in constricted channel flows and shear flows, and explore the dependence of the gating on flow rate, cell shape and size. The results provide guidance for future experiments in inducing Mscl opening for various purposes such as drug delivery.

  14. VALIDATION OF CFD PREDICTIONS OF FLOW IN A 3D ALVEOLATED BEND WITH EXPERIMENTAL DATA

    PubMed Central

    VAN ERTBRUGGEN, C.; CORIERI, P.; THEUNISSEN, R.; RIETHMULLER, M.L.; DARQUENNE, C.

    2008-01-01

    Verifying numerical predictions with experimental data is an important aspect of any modeling studies. In the case of the lung, the absence of direct in-vivo flow measurements makes such verification almost impossible. We performed computational fluid dynamics (CFD) simulations in a 3D scaled-up model of an alveolated bend with rigid walls that incorporated essential geometrical characteristics of human alveolar structures and compared numerical predictions with experimental flow measurements made in the same model by Particle Image Velocimetry (PIV). Flow in both models was representative of acinar flow during normal breathing (0.82 ml/s). The experimental model was built in silicone and silicone oil was used as the carrier fluid. Flow measurements were obtained by an ensemble averaging procedure. CFD simulation was performed with STAR-CCM+ (CD-Adapco) using a polyhedral unstructured mesh. Velocity profiles in the central duct were parabolic and no bulk convection existed between the central duct and the alveoli. Velocities inside the alveoli were ∼2 orders of magnitude smaller than the mean velocity in the central duct. CFD data agreed well with those obtained by PIV. In the central duct, data agreed within 1%. The maximum simulated velocity along the centerline of the model was 0.5% larger than measured experimentally. In the alveolar cavities, data agreed within 15% on average. This suggests that CFD techniques can satisfactorily predict acinar-type flow. Such a validation ensure a great degree of confidence in the accuracy of predictions made in more complex models of the alveolar region of the lung using similar CFD techniques. PMID:17915225

  15. Assessing GPR Signal Polarization for 3D Imaging of Fracture Flow Channels

    NASA Astrophysics Data System (ADS)

    Tsoflias, G. P.; Baker, M.; Becker, M. W.

    2011-12-01

    Ground penetrating radar (GPR) is an effective geophysical method for imaging fractures. Recent studies have employed GPR to image flow paths in fractured aquifers and have demonstrated the potential for relating radar signal attributes to tracer concentration and fracture hydraulic properties. Flow in natural fractures is highly heterogeneous and occurs through channeled paths of varying direction, width and aperture. Therefore, radar imaging of channeled flow may exhibit polarization effects analogous to imaging pipes in the subsurface. Electromagnetic wave polarization properties have been recognized for their significance in imaging buried pipes and rebar, as well as heterogeneous geologic environments including dipping layers and faults. In this study we explore EM wavefield polarization effects for 3D imaging of flow channels along a sub-horizontal water-saturated fracture in bedrock. Three-dimensional 50 and 100 MHz GPR reflection data were acquired using broadside and cross-polarized dipole antenna pairs oriented at 0, 45, 90 and 135 degrees to the survey grid lines. Although the sub-horizontal fracture surface was imaged by all surveys, significant differences in spatial variability of reflector amplitude strength is observed among the data grids suggesting strong signal polarization dependence. One approach for compensating dipole source radiation effects is to sum orthogonal orientation components to simulate circular source radiation. Comparison of summed orthogonal component grids shows very good agreement in imaging high amplitude features of the fracture reflector, delineating the position of channels along the fracture. We conclude that GPR polarization properties are important for accurate imaging of flow channeling along fractures. Acquisition of two orthogonal orientation broadside data using dipole source-receiver pairs is shown to be adequate for imaging flow channeling.

  16. Multilevel local refinement and multigrid methods for 3-D turbulent flow

    SciTech Connect

    Liao, C.; Liu, C.; Sung, C.H.; Huang, T.T.

    1996-12-31

    A numerical approach based on multigrid, multilevel local refinement, and preconditioning methods for solving incompressible Reynolds-averaged Navier-Stokes equations is presented. 3-D turbulent flow around an underwater vehicle is computed. 3 multigrid levels and 2 local refinement grid levels are used. The global grid is 24 x 8 x 12. The first patch is 40 x 16 x 20 and the second patch is 72 x 32 x 36. 4th order artificial dissipation are used for numerical stability. The conservative artificial compressibility method are used for further improvement of convergence. To improve the accuracy of coarse/fine grid interface of local refinement, flux interpolation method for refined grid boundary is used. The numerical results are in good agreement with experimental data. The local refinement can improve the prediction accuracy significantly. The flux interpolation method for local refinement can keep conservation for a composite grid, therefore further modify the prediction accuracy.

  17. Progress Toward Overset-Grid Moving Body Capability for USM3D Unstructured Flow Solver

    NASA Technical Reports Server (NTRS)

    Pandyna, Mohagna J.; Frink, Neal T.; Noack, Ralph W.

    2005-01-01

    A static and dynamic Chimera overset-grid capability is added to an established NASA tetrahedral unstructured parallel Navier-Stokes flow solver, USM3D. Modifications to the solver primarily consist of a few strategic calls to the Donor interpolation Receptor Transaction library (DiRTlib) to facilitate communication of solution information between various grids. The assembly of multiple overlapping grids into a single-zone composite grid is performed by the Structured, Unstructured and Generalized Grid AssembleR (SUGGAR) code. Several test cases are presented to verify the implementation, assess overset-grid solution accuracy and convergence relative to single-grid solutions, and demonstrate the prescribed relative grid motion capability.

  18. Electroosmotic flow through a microparallel channel with 3D wall roughness.

    PubMed

    Chang, Long; Jian, Yongjun; Buren, Mandula; Sun, Yanjun

    2016-02-01

    In this paper, a perturbation method is introduced to study the EOF in a microparallel channel with 3D wall roughness. The corrugations of the two walls are periodic sinusoidal waves of small amplitude in two directions either in phase or half-period out of phase. Based on linearized Poisson-Boltzmann equation, Laplace equation, and the Navier-Stokes equations, the perturbation solutions of velocity, electrical potential, and volume flow rate are obtained. By using numerical computation, the influences of the wall corrugations on the mean velocity are analyzed. The variations of electrical potential, velocity profile, mean velocity, and their dependences on the wave number α and β of wall corrugations in two directions, the nondimensional electrokinetic width K, and the zeta potential ratio between the lower wall and the upper wall ς are analyzed graphically. PMID:26333852

  19. Ergodic theory and experimental visualization of chaos in 3D flows

    NASA Astrophysics Data System (ADS)

    Sotiropoulos, Fotis; Mezic, Igor

    2000-11-01

    In his motivation for the ergodic hypothesis Gibbs invoked an analogy with fluid mixing: “…Yet no fact is more familiar to us than that stirring tends to bring a liquid to a state of uniform mixture, or uniform densities of its components…”. Although proof of the ergodic hypothesis is possible only for the simplest of systems using methods from ergodic theory, the use of the hypothesis has led to many accurate predictions in statistical mechanics. The problem of fluid mixing, however, turned out to be considerably more complicated than Gibbs envisioned. Chaotic advection can indeed lead to efficient mixing even in non-turbulent flows, but many non-mixed islands are known to persist within well-mixed regions. In numerical studies, Poincaré maps can be used to reveal the structure of such islands but their visualization in the laboratory requires laborious experimental procedures and is possible only for certain types of flows. Here we propose the first non-intrusive, simple to implement, and generally applicable technique for constructing experimental Poincaré maps and apply it to a steady, 3D, vortex breakdown bubble. We employ standard laser-induced fluorescence (LIF) and construct Poincaré maps by time averaging a sufficiently long sequence of instantaneous LIF images. We also show that ergodic theory methods provide a rigorous theoretical justification for this approach whose main objective is to reveal the non-ergodic regions of the flow.

  20. Multigrid direct numerical simulation of the whole process of flow transition in 3-D boundary layers

    NASA Technical Reports Server (NTRS)

    Liu, Chaoqun; Liu, Zhining

    1993-01-01

    A new technology was developed in this study which provides a successful numerical simulation of the whole process of flow transition in 3-D boundary layers, including linear growth, secondary instability, breakdown, and transition at relatively low CPU cost. Most other spatial numerical simulations require high CPU cost and blow up at the stage of flow breakdown. A fourth-order finite difference scheme on stretched and staggered grids, a fully implicit time marching technique, a semi-coarsening multigrid based on the so-called approximate line-box relaxation, and a buffer domain for the outflow boundary conditions were all used for high-order accuracy, good stability, and fast convergence. A new fine-coarse-fine grid mapping technique was developed to keep the code running after the laminar flow breaks down. The computational results are in good agreement with linear stability theory, secondary instability theory, and some experiments. The cost for a typical case with 162 x 34 x 34 grid is around 2 CRAY-YMP CPU hours for 10 T-S periods.

  1. Dynamic coupling between fluid flow and vein growth in fractures: a 3D numerical model

    NASA Astrophysics Data System (ADS)

    Schwarz, J.-O.; Enzmann, F.

    2012-04-01

    Fluid flow is one of the main mass transport mechanisms in the Earth's crust and abundant mineral vein networks are important indicators for fluid flow and fluid rock interaction. These systems are dynamic and part of the so called RTM processes (reaction-transport-mechanics). Understanding of mineral vein systems requires coupling of these processes. Here we present a conceptional model for dynamic vein growth of syntaxial, posttectonic veins generated by advective fluid flow and show first results of a numerical model for this scenario. Vein generation requires three processes to occur: (i) fracture generation by mechanical stress e.g. hydro-fracturing, (ii) flow of a supersaturated fluid on that fracture and (iii) crystallization of phase(s) on or in the fracture. 3D synthetic fractures are generated with the SynFrac code (Ogilvie, et al. 2006). Subsequently solutions of the Navier-Stokes equation for this fracture are computed by a computational fluid dynamics code called GeoDict (Wiegmann 2007). Transport (advective and diffusive) of chemical species to growth sites in the fracture and vein growth are computed by a self-written MATLAB script. The numerical model discretizes the wall rock and fracture geometry by volumetric pixels (voxels). Based on this representation, the model computes the three basic functions for vein generation: (a) nucleation, (b) fluid flow with transport of chemical species and (c) growth. The following conditions were chosen for these three modules. Nucleation is heterogeneous and occurs instantaneously at the wall rock/fracture interface. Advective and diffusive flow of a supersaturated fluid and related transport of chemical species occurs according to the computed fluid flow field by GeoDict. Concentration of chemical species at the inflow is constant, representing external fluid buffering. Changes/decrease in the concentration of chemical species occurs only due to vein growth. Growth of nuclei is limited either by transport of

  2. Enhancement of USM3D Unstructured Flow Solver for High-Speed High-Temperature Shear Flows

    NASA Technical Reports Server (NTRS)

    Pandya, Mohagna J.; Abdol-Hamid, Khaled S.; Frink, Neal T.

    2009-01-01

    Large temperature and pressure fluctuations have a profound effect on turbulence development in transonic and supersonic jets. For high-speed, high-temperature jet flows, standard turbulence models lack the ability to predict the observed mixing rate of a shear layer. Several proposals to address this deficiency have been advanced in the literature to modify the turbulence transport equations in a variety of ways. In the present study, some of the most proven and simple modifications to two-equation turbulence models have been selected and implemented in NASA's USM3D tetrahedral Navier-Stokes flow solver. The modifications include the addition of compressibility correction and pressure dilatation terms in the turbulence transport equations for high-speed flows, and the addition of a simple modification to the Boussinesq's closure model coefficient for high-temperature jets. The efficacy of the extended models is demonstrated by comparison with experimental data for two supersonic axisymmetric jet test cases at design pressure ratio.

  3. Development of seismic anisotropy during subduction-induced 3D mantle flow

    NASA Astrophysics Data System (ADS)

    Faccenda, M.; capitanio, F. A.

    2012-12-01

    Subduction zones are convergent margins where the rigid lithosphere sinks into the Earth's mantle inducing complex 3D flow patterns. Seismic anisotropy generated by strain-induced lattice/crystal preferred orientation (LPO/CPO) of intrinsically anisotropic minerals is commonly used to study flow in the mantle and its relations with plate motions. As the development of seismic anisotropy due to upper and lower plate motions occurs at depths and timescales such that it is not directly observable, numerical modelling provides a useful tool to investigate these processes. We computed the seismic anisotropy of dry olivine-enstatite aggregates due to strain-induced LPO in 3D mechanical models of dynamic subduction by using, respectively, D-Rex and Underworld. Subsequently, FSTRACK was used to compute seismogram synthetics and SKS splitting patterns. We found that for relatively narrow subducting plates, retreat motions are maximized producing strong subslab trench-parallel anisotropy. Here, synthetic data reproduce quite well the observations in analogous subduction systems like Calabria and South Sandwich, where the fast azimuths orients parallel to the trench in the forearc and follow the toroidal flow patterns on the slab edges. Furthermore, we found that the amount of anisotropy is proportional to the amount of subduction, while it does not depend on the rate at which the plate subducts. On the other hand, larger subducting plates subducts mainly by plate advance, favoring poloidal motions and trench-perpendicular anisotropy. Additional Earth-like plate geometries involving along-trench variation of the subducting plate age that induces differential slab retreat motions are considered. We also tested different olivine fabrics (A, B, C, E type), yielding distinct SKS splitting patterns that may help to constrain the composition of the upper mantle. Although more sophisticated numerical modelling taking into account temperature-dependent mantle rock rheologies and P

  4. Investigation of the effect of wall friction on the flow rate in 2D and 3D Granular Flow

    NASA Astrophysics Data System (ADS)

    Carballo-Ramirez, Brenda; Pleau, Mollie; Easwar, Nalini; Birwa, Sumit; Shah, Neil; Tewari, Shubha

    We have measured the mass flow rate of spherical steel spheres under gravity in vertical, straight-walled 2 and 3-dimensional hoppers, where the flow velocity is controlled by the opening size. Our measurements focus on the role of friction and its placement along the walls of the hopper. In the 2D case, an increase in the coefficient of static friction from μ = 0.2 to 0.6 is seen to decrease the flow rate significantly. We have changed the placement of frictional boundaries/regions from the front and back walls of the 2D hopper to the side walls and floor to investigate the relative importance of the different regions in determining the flow rate. Fits to the Beverloo equation show significant departure from the expected exponent of 1.5 in the case of 2D flow. In contrast, 3D flow rates do not show much dependence on wall friction and its placement. We compare the experimental data to numerical simulations of gravity driven hopper granular flow with varying frictional walls constructed using LAMMPS*. *http://lammps.sandia.gov Supported by NSF MRSEC DMR 0820506.

  5. Secondary flow structure in a model curved artery: 3D morphology and circulation budget analysis

    NASA Astrophysics Data System (ADS)

    Bulusu, Kartik V.; Plesniak, Michael W.

    2015-11-01

    In this study, we examined the rate of change of circulation within control regions encompassing the large-scale vortical structures associated with secondary flows, i.e. deformed Dean-, Lyne- and Wall-type (D-L-W) vortices at planar cross-sections in a 180° curved artery model (curvature ratio, 1/7). Magnetic resonance velocimetry (MRV) and particle image velocimetry (PIV) experiments were performed independently, under the same physiological inflow conditions (Womersley number, 4.2) and using Newtonian blood-analog fluids. The MRV-technique performed at Stanford University produced phase-averaged, three-dimensional velocity fields. Secondary flow field comparisons of MRV-data to PIV-data at various cross-sectional planes and inflow phases were made. A wavelet-decomposition-based approach was implemented to characterize various secondary flow morphologies. We hypothesize that the persistence and decay of arterial secondary flow vortices is intrinsically related to the influence of the out-of-plane flow, tilting, in-plane convection and diffusion-related factors within the control regions. Evaluation of these factors will elucidate secondary flow structures in arterial hemodynamics. Supported by the National Science Foundation under Grant Number CBET-0828903, and GW Center for Biomimetics and Bioinspired Engineering (COBRE). The MRV data were acquired at Stanford University in collaboration with Christopher Elkins and John Eaton.

  6. Label-free 3D imaging of microstructure, blood, and lymphatic vessels within tissue beds in vivo.

    PubMed

    Zhi, Zhongwei; Jung, Yeongri; Wang, Ruikang K

    2012-03-01

    This Letter reports the use of an ultrahigh resolution optical microangiography (OMAG) system for simultaneous 3D imaging of microstructure and lymphatic and blood vessels without the use of an exogenous contrast agent. An automatic algorithm is developed to segment the lymphatic vessels from the microstructural images based on the fact that the lymph fluid is optically transparent. An OMAG system is developed that utilizes a broadband supercontinuum light source, providing an axial resolution of 2.3 μm and lateral resolution of 5.8 μm, capable of resolving the capillary vasculature and lymphatic vessels innervating microcirculatory tissue beds. Experimental demonstration is performed by showing detailed 3D lymphatic and blood vessel maps, coupled with morphology, within mouse ears in vivo.

  7. Label-free 3D imaging of microstructure, blood and lymphatic vessels within tissue beds in vivo

    PubMed Central

    Zhi, Zhongwei; Jung, Yeongri; Wang, Ruikang K.

    2014-01-01

    This letter reports the use of an ultrahigh resolution optical microangiography (OMAG) system for simultaneous 3D imaging of microstructure, lymphatic and blood vessels without the use of exogenous contrast agent. An automatic algorithm is developed to segment the lymphatic vessels from the microstructural images, based on the fact that the lymph fluid is optically transparent. The OMAG system is developed that utilizes a broadband supercontinuum light source, providing an axial resolution of 2.3 μm and lateral resolution of 5.8 μm, capable of resolving the capillary vasculature and lymphatic vessels innervating microcirculatory tissue beds. Experimental demonstration is performed by showing detailed 3D lymphatic and blood vessel maps, coupled with morphology, within mouse ears in vivo. PMID:22378402

  8. Unstructured Cartesian refinement with sharp interface immersed boundary method for 3D unsteady incompressible flows

    NASA Astrophysics Data System (ADS)

    Angelidis, Dionysios; Chawdhary, Saurabh; Sotiropoulos, Fotis

    2016-11-01

    A novel numerical method is developed for solving the 3D, unsteady, incompressible Navier-Stokes equations on locally refined fully unstructured Cartesian grids in domains with arbitrarily complex immersed boundaries. Owing to the utilization of the fractional step method on an unstructured Cartesian hybrid staggered/non-staggered grid layout, flux mismatch and pressure discontinuity issues are avoided and the divergence free constraint is inherently satisfied to machine zero. Auxiliary/hanging nodes are used to facilitate the discretization of the governing equations. The second-order accuracy of the solver is ensured by using multi-dimension Lagrange interpolation operators and appropriate differencing schemes at the interface of regions with different levels of refinement. The sharp interface immersed boundary method is augmented with local near-boundary refinement to handle arbitrarily complex boundaries. The discrete momentum equation is solved with the matrix free Newton-Krylov method and the Krylov-subspace method is employed to solve the Poisson equation. The second-order accuracy of the proposed method on unstructured Cartesian grids is demonstrated by solving the Poisson equation with a known analytical solution. A number of three-dimensional laminar flow simulations of increasing complexity illustrate the ability of the method to handle flows across a range of Reynolds numbers and flow regimes. Laminar steady and unsteady flows past a sphere and the oblique vortex shedding from a circular cylinder mounted between two end walls demonstrate the accuracy, the efficiency and the smooth transition of scales and coherent structures across refinement levels. Large-eddy simulation (LES) past a miniature wind turbine rotor, parameterized using the actuator line approach, indicates the ability of the fully unstructured solver to simulate complex turbulent flows. Finally, a geometry resolving LES of turbulent flow past a complete hydrokinetic turbine illustrates

  9. Automated quantitative analysis of 3D morphology and mean corpuscular hemoglobin in human red blood cells stored in different periods.

    PubMed

    Moon, Inkyu; Yi, Faliu; Lee, Yeon H; Javidi, Bahram; Boss, Daniel; Marquet, Pierre

    2013-12-16

    Quantitative phase (QP) images of red blood cells (RBCs), which are obtained by off-axis digital holographic microscopy, can provide quantitative information about three-dimensional (3D) morphology of human RBCs and the characteristic properties such as mean corpuscular hemoglobin (MCH) and MCH surface density (MCHSD). In this paper, we investigate modifications of the 3D morphology and MCH in RBCs induced by the period of storage time for the purpose of classification of RBCs with different periods of storage by using off-axis digital holographic microscopy. The classification of RBCs based on the duration of storage is highly relevant because a long storage of blood before transfusion may alter the functionality of RBCs and, therefore, cause complications in patients. To analyze any changes in the 3D morphology and MCH of RBCs due to storage, we use data sets from RBC samples stored for 8, 13, 16, 23, 27, 30, 34, 37, 40, 47, and 57 days, respectively. The data sets consist of more than 3,300 blood cells in eleven classes, with more than 300 blood cells per class. The classes indicate the storage period of RBCs and are listed in chronological order. Using the RBCs donated by healthy persons, the off-axis digital holographic microscopy reconstructs several quantitative phase images of RBC samples stored for eleven different periods. We employ marker-controlled watershed transform to remove the background in the RBC quantitative phase images obtained by the off-axis digital holographic microscopy. More than 300 single RBCs are extracted from the segmented quantitative phase images for each class. Such a large number of RBC samples enable us to obtain statistical distributions of the characteristic properties of RBCs after a specific period of storage. Experimental results show that the 3D morphology of the RBCs, in contrast to MCH, is essentially related to the aging of the RBCs.

  10. CFD Simulation of 3D Flow field in a Gas Centrifuge

    SciTech Connect

    Dongjun Jiang; Shi Zeng

    2006-07-01

    A CFD method was used to study the whole flow field in a gas centrifuge. In this paper, the VSM (Vector Splitting Method) of the FVM (Finite Volume Method) was used to solve the 3D Navier-Stokes equations. An implicit second-order upwind scheme was adopted. The numerical simulation was successfully performed on a parallel cluster computer and a convergence result was obtained. The simulation shows that: in the withdrawal chamber, a strong detached shock wave is formed in front of the scoop; as the radial position increases, the shock becomes stronger and the distance to scoop front surface is smaller. An oblique shock forms in the clearance between the scoop and the centrifuge wall; behind the shock-wave, the radially-inward motion of gas is induced because of the imbalance of the pressure gradient and the centrifugal force. In the separation chamber, a countercurrent is introduced. This indicates that CFD method can be used to study the complex three-dimensional flow field of gas centrifuges. (authors)

  11. Numerical Calculations of 3-D High-Lift Flows and Comparison with Experiment

    NASA Technical Reports Server (NTRS)

    Compton, William B, III

    2015-01-01

    Solutions were obtained with the Navier-Stokes CFD code TLNS3D to predict the flow about the NASA Trapezoidal Wing, a high-lift wing composed of three elements: the main-wing element, a deployed leading-edge slat, and a deployed trailing-edge flap. Turbulence was modeled by the Spalart-Allmaras one-equation turbulence model. One case with massive separation was repeated using Menter's two-equation SST (Menter's Shear Stress Transport) k-omega turbulence model in an attempt to improve the agreement with experiment. The investigation was conducted at a free stream Mach number of 0.2, and at angles of attack ranging from 10.004 degrees to 34.858 degrees. The Reynolds number based on the mean aerodynamic chord of the wing was 4.3 x 10 (sup 6). Compared to experiment, the numerical procedure predicted the surface pressures very well at angles of attack in the linear range of the lift. However, computed maximum lift was 5% low. Drag was mainly under predicted. The procedure correctly predicted several well-known trends and features of high-lift flows, such as off-body separation. The two turbulence models yielded significantly different solutions for the repeated case.

  12. USM3D Simulations of Saturn V Plume Induced Flow Separation

    NASA Technical Reports Server (NTRS)

    Deere, Karen; Elmlilgui, Alaa; Abdol-Hamid, K. S.

    2011-01-01

    The NASA Constellation Program included the Ares V heavy lift cargo vehicle. During the design stage, engineers questioned if the Plume Induced Flow Separation (PIFS) that occurred along Saturn V rocket during moon missions at some flight conditions, would also plague the newly proposed rocket. Computational fluid dynamics (CFD) was offered as a tool for initiating the investigation of PIFS along the Ares V rocket. However, CFD best practice guidelines were not available for such an investigation. In an effort to establish a CFD process and define guidelines for Ares V powered simulations, the Saturn V vehicle was used because PIFS flight data existed. The ideal gas, computational flow solver USM3D was evaluated for its viability in computing PIFS along the Saturn V vehicle with F-1 engines firing. Solutions were computed at supersonic freestream conditions, zero degree angle of attack, zero degree sideslip, and at flight Reynolds numbers. The effects of solution sensitivity to grid refinement, turbulence models, and the engine boundary conditions on the predicted PIFS distance along the Saturn V were discussed and compared to flight data from the Apollo 11 mission AS-506.

  13. 3D Markov Process for Traffic Flow Prediction in Real-Time

    PubMed Central

    Ko, Eunjeong; Ahn, Jinyoung; Kim, Eun Yi

    2016-01-01

    Recently, the correct estimation of traffic flow has begun to be considered an essential component in intelligent transportation systems. In this paper, a new statistical method to predict traffic flows using time series analyses and geometric correlations is proposed. The novelty of the proposed method is two-fold: (1) a 3D heat map is designed to describe the traffic conditions between roads, which can effectively represent the correlations between spatially- and temporally-adjacent traffic states; and (2) the relationship between the adjacent roads on the spatiotemporal domain is represented by cliques in MRF and the clique parameters are obtained by example-based learning. In order to assess the validity of the proposed method, it is tested using data from expressway traffic that are provided by the Korean Expressway Corporation, and the performance of the proposed method is compared with existing approaches. The results demonstrate that the proposed method can predict traffic conditions with an accuracy of 85%, and this accuracy can be improved further. PMID:26821025

  14. A digital holography set-up for 3D vortex flow dynamics

    NASA Astrophysics Data System (ADS)

    Lebon, Benoît; Perret, Gaële; Coëtmellec, Sébastien; Godard, Gilles; Gréhan, Gérard; Lebrun, Denis; Brossard, Jérôme

    2016-06-01

    In the present paper, a digital in-line holography (DIH) set-up, with a converging beam, is used to take three-dimensional (3D) velocity measurements of vortices. The vortices are formed periodically at the edges of a submerged horizontal plate submitted to regular waves. They take the form of vortex filaments that extend from side to side of the channel. They undergo strongly three-dimensional instability mechanisms that remain very complicated to characterize experimentally. The experiments are performed in a 10 × 0.3 × 0.3 m3 wave flume. The DIH set-up is performed using a modulated laser diode emitting at the wavelength of 640 nm and a lensless CCD camera. The beam crosses the channel side to side. To reveal the flow dynamics, 30-μm hydrogen bubbles are generated at the edge of the plate to serve as tracers. Their locations are recorded on the holograms multiple times to access the dynamics of the flow. This method leads to an accuracy in the order of 100 μm on the axial location. Those measurements have been validated with stereo-PIV measurements. A very good agreement is found on time-averaged velocity fields between the two techniques.

  15. Simulation of bacteria transport processes in a river with Flow3D

    NASA Astrophysics Data System (ADS)

    Schwarzwälder, Kordula; Bui, Minh Duc; Rutschmann, Peter

    2014-05-01

    Water quality aspects are getting more and more important due to the European water Framework directive (WFD). One problem related to this topic is the inflow of untreated wastewater due to combined sewer overflows into a river. The wastewater mixture contains even bacteria like E. coli and Enterococci which are markers for water quality. In our work we investigated the transport of these bacteria in river Isar by using a large-scale flume in the outside area of our lab (Oskar von Miller Institute). Therefor we could collect basic data and knowledge about the processes which occur during bacteria sedimentation and remobilisation. In our flume we could use the real grain with the exact size distribution curve as in the river Isar which we want to simulate and we had the chance to nurture a biofilm which is realistic for the analysed situation. This biofilm plays an important role in the remobilisation processes, because the bacteria are hindered to be washed out back into the bulk phase as fast and in such an amount as this would happen without biofilm. The results of our experiments are now used for a module in the 3D software Flow3D to simulate the effects of a point source inlet of raw wastewater on the water quality. Therefor we have to implement the bacteria not as a problem of concentration with advection and diffusion but as single particles which can be inactivated during the process of settling and need to be hindered from remobilisation by the biofilm. This biofilm has special characteristic, it is slippery and has a special thickness which influences the chance of bacteria being removed. To achieve realistic results we have to include the biofilm with more than a probabilistic-tool to make sure that our module is transferable. The module should be as flexible as possible to be improved step by step with increasing quality of dataset.

  16. Experiments and 3D simulations of flow structures in junctions and their influence on location of flowmeters.

    PubMed

    Mignot, E; Bonakdari, H; Knothe, P; Lipeme Kouyi, G; Bessette, A; Rivière, N; Bertrand-Krajewski, J-L

    2012-01-01

    Open-channel junctions are common occurrences in sewer networks and flow rate measurement often occurs near these singularities. Local flow structures are 3D, impact on the representativeness of the local flow measurements and thus lead to deviations in the flow rate estimation. The present study aims (i) to measure and simulate the flow pattern in a junction flow, (ii) to analyse the impact of the junction on the velocity distribution according to the distance from the junction and thus (iii) to evaluate the typical error derived from the computation of the flow rate close to the junction. PMID:22828313

  17. Regulation of pulpal blood flow

    SciTech Connect

    Kim, S.

    1985-04-01

    The regulation of blood flow of the dental pulp was investigated in dogs and rats anesthetized with sodium pentobarbital. Pulpal blood flow was altered by variations of local and systemic hemodynamics. Macrocirculatory blood flow (ml/min/100 g) in the dental pulp was measured with both the /sup 133/Xe washout and the 15-microns radioisotope-labeled microsphere injection methods on the canine teeth of dogs, to provide a comparison of the two methods in the same tooth. Microcirculatory studies were conducted in the rat incisor tooth with microscopic determination of the vascular pattern, RBC velocity, and intravascular volumetric flow distribution. Pulpal resistance vessels have alpha- and beta-adrenergic receptors. Activation of alpha-receptors by intra-arterial injection of norepinephrine (NE) caused both a reduction in macrocirculatory Qp in dogs and decreases in arteriolar and venular diameters and intravascular volumetric flow (Qi) in rats. These responses were blocked by the alpha-antagonist PBZ. Activation of beta-receptors by intra-arterial injection of isoproterenal (ISO) caused a paradoxical reduction of Qp in dogs. In rats, ISO caused a transient increase in arteriolar Qi followed by a flow reduction; arteriolar dilation was accompanied by venular constriction. These macrocirculatory and microcirculatory responses to ISO were blocked by the alpha-antagonist propranolol.

  18. Heat Flow Partitioning Between Continents and Oceans - from 2D to 3D

    NASA Astrophysics Data System (ADS)

    Moresi, L. N.; Cooper, C. M.; Lenardic, A.

    2010-12-01

    Scalings derived from thermal network theory explain how the presence of continents can influence the Earth’s overall heat loss. Intuitively, it may seem that increasing the proportion of a planet’s surface area covered by continents would decrease the efficiency of heat transfer given that continents do not participate in convective overturn. However, this ignores the potential feedback between the insulating effect of continents and the temperature-dependent viscosity of the mantle (Lenardic et al, 2005, Cooper et al, 2007). When this feedback is considered, a clear regime exists in which the partial stagnation and insulation of the surface by buoyant continental crust can lead to an increase in heat flow compared to the uninsulated case. The numerical results used to verify the scalings have mostly been conducted in two dimensions in order to cover a very wide range of Rayleigh number, fraction of continental coverage, and continental thickness. However as more recent results show that the configuration of the crust also plays a role in determining the heat flow partitioning and global heat flow (See Lenardic et al, “Continents, Super-Continents, Mantle Thermal Mixing, and Mantle Thermal Isolation” in this session), we have begun to repeat this exhaustive and exhausting 2D study in 3D. Cooper, C.M., A. Lenardic, and L.-N. Moresi "Effects of continental insulation and the partioning of heat producing elements on the Earth's heat loss." Geophys. Res. Lett., 33 ,10.1029, 2006. Lenardic, A., L.-N. Moresi, A.M. Jellinek, and M. Manga "Continental insulation, mantle cooling, and the surface area of oceans and continents." Earth Planet. Sci. Lett., 234 ,317-333, 2005.

  19. Experimental Investigation of Material Flows Within FSWs Using 3D Tomography

    SciTech Connect

    Charles R. Tolle; Timothy A. White; Karen S. Miller; Denis E. Clark; Herschel B. Smartt

    2008-06-01

    There exists significant prior work using tracers or pre-placed hardened markers within friction stir welding (FSWing) to experimentally explore material flow within the FSW process. Our experiments replaced markers with a thin sheet of copper foil placed between the 6061 aluminum lap and butt joints that were then welded. The absorption characteristics of x-rays for copper and aluminum are significantly different allowing for non-destructive evaluation (NDE) methods such as x-ray computed tomography (CT) to be used to demonstrate the material movement within the weldment on a much larger scale than previously shown. 3D CT reconstruction of the copper components of the weldment allows for a unique view into the final turbulent state of the welding process as process parameters are varied. The x-ray CT data of a section of the weld region was collected using a cone-beam x-ray imaging system developed at the INL. Six-hundred projections were collected over 360-degrees using a 160-kVp Bremsstrahlung x-ray generator (25-micrometer focal spot) and amorphoussilicon x-ray detector. The region of the object that was imaged was about 3cm tall and 1.5cm x 1cm in cross section, and was imaged at a magnification of about 3.6x. The data were reconstructed on a 0.5x0.5x0.5 mm3 voxel grid. After reconstruction, the aluminum and copper could be easily discriminated using a gray level threshold allowing visualization of the copper components. Fractal analysis of the tomographic reconstructed material topology is investigated as a means to quantify macro level material flow based on process parameters. The results of multi-pass FSWs show increased refinement of the copper trace material. Implications of these techniques for quantifying process flow are discussed.

  20. Using a magnetite/thermoplastic composite in 3D printing of direct replacements for commercially available flow sensors

    NASA Astrophysics Data System (ADS)

    Leigh, S. J.; Purssell, C. P.; Billson, D. R.; Hutchins, D. A.

    2014-09-01

    Flow sensing is an essential technique required for a wide range of application environments ranging from liquid dispensing to utility monitoring. A number of different methodologies and deployment strategies have been devised to cover the diverse range of potential application areas. The ability to easily create new bespoke sensors for new applications is therefore of natural interest. Fused deposition modelling is a 3D printing technology based upon the fabrication of 3D structures in a layer-by-layer fashion using extruded strands of molten thermoplastic. The technology was developed in the late 1980s but has only recently come to more wide-scale attention outside of specialist applications and rapid prototyping due to the advent of low-cost 3D printing platforms such as the RepRap. Due to the relatively low-cost of the printers and feedstock materials, these printers are ideal candidates for wide-scale installation as localized manufacturing platforms to quickly produce replacement parts when components fail. One of the current limitations with the technology is the availability of functional printing materials to facilitate production of complex functional 3D objects and devices beyond mere concept prototypes. This paper presents the formulation of a simple magnetite nanoparticle-loaded thermoplastic composite and its incorporation into a 3D printed flow-sensor in order to mimic the function of a commercially available flow-sensing device. Using the multi-material printing capability of the 3D printer allows a much smaller amount of functional material to be used in comparison to the commercial flow sensor by only placing the material where it is specifically required. Analysis of the printed sensor also revealed a much more linear response to increasing flow rate of water showing that 3D printed devices have the potential to at least perform as well as a conventionally produced sensor.

  1. Thermocapillary bubble flow and coalescence in a rotating cylinder: A 3D study

    NASA Astrophysics Data System (ADS)

    Alhendal, Yousuf; Turan, A.; Al-mazidi, M.

    2015-12-01

    The process of thermocapillary bubbles rising in a rotating 3D cylinder in zero gravity was analysed and presented numerically with the aid of computational fluid dynamics (CFD) by means of the volume of fluid (VOF) method. Calculations were carried out to investigate in detail the effect of the rotational speed of the hosted liquid on the trajectory of both single and group bubbles driven by the Marangoni force in zero-gravity conditions. For rotational speeds from 0.25 to 2 rad/s, bubble displacement with angular motion was found to be directed between the hotter surface and the rotational axis. This is contrary to the conventional bubble flow from areas of high pressure to low pressure, radial direction, or from cold to hot regions, axial direction. The results demonstrate that for the ratio of rotational speeds to the thermocapillary bubble velocity larger than unity, the surface tension gradient is the dominant force and the bubble motion towards the hotter. On the other hand, for ratio less than 1, the bubble motion is dominated and is significantly affected by centrifugal force. As rotation speed increases, the amount of deflection increases and the Marangoni effect vanishes. The current study is novel in the sense that single- and multi-bubble motion incorporating thermocapillary forces in a rotating liquid in a zero-gravity environment has never been numerically investigated.

  2. A 3-D Vortex Code for Parachute Flow Predictions: VIPAR Version 1.0

    SciTech Connect

    STRICKLAND, JAMES H.; HOMICZ, GREGORY F.; PORTER, VICKI L.; GOSSLER, ALBERT A.

    2002-07-01

    This report describes a 3-D fluid mechanics code for predicting flow past bluff bodies whose surfaces can be assumed to be made up of shell elements that are simply connected. Version 1.0 of the VIPAR code (Vortex Inflation PARachute code) is described herein. This version contains several first order algorithms that we are in the process of replacing with higher order ones. These enhancements will appear in the next version of VIPAR. The present code contains a motion generator that can be used to produce a large class of rigid body motions. The present code has also been fully coupled to a structural dynamics code in which the geometry undergoes large time dependent deformations. Initial surface geometry is generated from triangular shell elements using a code such as Patran and is written into an ExodusII database file for subsequent input into VIPAR. Surface and wake variable information is output into two ExodusII files that can be post processed and viewed using software such as EnSight{trademark}.

  3. Effects of flow control over a 3D turret -- Part II

    NASA Astrophysics Data System (ADS)

    Wallace, Ryan; Andino, Marlyn; Schmit, Ryan; Camphouse, Chris; Myatt, James; Glauser, Mark

    2007-11-01

    Building upon the 3D turret work done at Syracuse University an extended study was conducted in the Air Force Research Laboratory's Subsonic Aerodynamic Research Laboratory (SARL) wind tunnel at Wright-Patterson Air Force Base. The SARL experiments were performed at higher Reynolds and Mach numbers and therefore present a more complex, more challenging flow. Synthetic jets mounted upstream of the aperture were used to generate multiple actuation cases in order to provide a rich ensemble for plant model development based on the split POD method of Camphouse (2007). PIV velocity data was acquired along with simultaneous surface pressure data at various planes across the turret with and without open-loop control. In addition, a simple proportional closed-loop control was performed using the bandpass filtered first POD mode coefficient of the surface pressure as the feedback signal. The amplitude of the feedback signal was calibrated using the open-loop results which were the most effective in reducing the separation zone of the turret.

  4. A Quasi-3-D Theory for Impedance Eduction in Uniform Grazing Flow

    NASA Technical Reports Server (NTRS)

    Watson, W. R.; Jones, M. G.; Parrott, T. L.

    2005-01-01

    A 2-D impedance eduction methodology is extended to quasi-3-D sound fields in uniform or shearing mean flow. We introduce a nonlocal, nonreflecting boundary condition to terminate the duct and then educe the impedance by minimizing an objective function. The introduction of a parallel, sparse, equation solver significantly reduces the wall clock time for educing the impedance when compared to that of the sequential band solver used in the 2-D methodology. The accuracy, efficiency, and robustness of the methodology is demonstrated using two examples. In the first example, we show that the method reproduces the known impedance of a ceramic tubular test liner. In the second example, we illustrate that the approach educes the impedance of a four-segment liner where the first, second, and fourth segments consist of a perforated face sheet bonded to honeycomb, and the third segment is a cut from the ceramic tubular test liner. The ability of the method to educe the impedances of multisegmented liners has the potential to significantly reduce the amount of time and cost required to determine the impedance of several uniform liners by allowing them to be placed in series in the test section and to educe the impedance of each segment using a single numerical experiment. Finally, we probe the objective function in great detail and show that it contains a single minimum. Thus, our objective function is ideal for use with local, inexpensive, gradient-based optimizers.

  5. Calculation of the virtual current in an electromagnetic flow meter with one bubble using 3D model.

    PubMed

    Zhang, Xiao-Zhang; Li, Yantao

    2004-04-01

    Based on the theory of electromagnetic induction flow measurement, the Laplace equation in a complicated three-dimensional (3D) domain is solved by an alternating method. Virtual current potentials are obtained for an electromagnetic flow meter with one spherical bubble inside. The solutions are used to investigate the effects of bubble size and bubble position on the virtual current. Comparisons are done among the cases of 2D and 3D models, and of point electrode and large electrode. The results show that the 2D model overestimates the effect, while large electrodes are least sensitive to the bubble. This paper offers fundamentals for the study of the behavior of an electromagnetic flow meter in multiphase flow. For application, the results provide a possible way to estimate errors of the flow meter caused by multiphase flow.

  6. Time-resolved fuel injector flow characterisation based on 3D laser Doppler vibrometry

    NASA Astrophysics Data System (ADS)

    Crua, Cyril; Heikal, Morgan R.

    2014-12-01

    Hydrodynamic turbulence and cavitation are known to play a significant role in high-pressure atomizers, but the small geometries and extreme operating conditions hinder the understanding of the flow’s characteristics. Diesel internal flow experiments are generally conducted using x-ray techniques or on transparent, and often enlarged, nozzles with different orifice geometries and surface roughness to those found in production injectors. In order to enable investigations of the fuel flow inside unmodified injectors, we have developed a new experimental approach to measure time-resolved vibration spectra of diesel nozzles using a 3D laser vibrometer. The technique we propose is based on the triangulation of the vibrometer and fuel pressure transducer signals, and enables the quantitative characterisation of quasi-cyclic internal flows without requiring modifications to the injector, the working fluid, or limiting the fuel injection pressure. The vibrometer, which uses the Doppler effect to measure the velocity of a vibrating object, was used to scan injector nozzle tips during the injection event. The data were processed using a discrete Fourier transform to provide time-resolved spectra for valve-closed-orifice, minisac and microsac nozzle geometries, and injection pressures ranging from 60 to 160 MPa, hence offering unprecedented insight into cyclic cavitation and internal mechanical dynamic processes. A peak was consistently found in the spectrograms between 6 and 7.5 kHz for all nozzles and injection pressures. Further evidence of a similar spectral peak was obtained from the fuel pressure transducer and a needle lift sensor mounted into the injector body. Evidence of propagation of the nozzle oscillations to the liquid sprays was obtained by recording high-speed videos of the near-nozzle diesel jet, and computing the fast Fourier transform for a number of pixel locations at the interface of the jets. This 6-7.5 kHz frequency peak is proposed to be the

  7. [Improved visualization of long-axis black-blood imaging of the carotid arteries using phase sensitive inversion recovery combined with 3D IR-T₁TFE].

    PubMed

    Horie, Tomohiko; Kawakata, Mami; Kajihara, Nao; Takano, Hayato; Honda, Masatoshi; Muro, Isao; Ogino, Tetsuo

    2011-01-01

    The purpose of this study was to improve the visualization of long-axis black-blood imaging of the carotid arteries. We experimented on phantom and in-vivo study of 3 dimension (3D) inversion recovery T(1) turbo field echo combined with phase sensitive inversion recovery (PSIR-3D IR-T(1)TFE) at 3.0 Tesla. As a result, the contrast has been improved by calculated images of PSIR-3D IR-T(1)TFE set to inversion time (TI) 350 ms that is shorter than null point of blood. This displays that the contrast between blood and tissues can be improved when the longitudinal magnetization of blood is a negative. Therefore, the visualization of long-axis black-blood imaging of the carotid arteries has been improved by the calculated images of PSIR-3D IR-T(1)TFE set to TI that is shorter than null point of blood.

  8. Characterizing 3-D flow velocity in evolving pore networks driven by CaCO3 precipitation and dissolution

    NASA Astrophysics Data System (ADS)

    Chojnicki, K. N.; Yoon, H.; Martinez, M. J.

    2015-12-01

    Understanding reactive flow in geomaterials is important for optimizing geologic carbon storage practices, such as using pore space efficiently. Flow paths can be complex in large degrees of geologic heterogeneities across scales. In addition, local heterogeneity can evolve as reactive transport processes alter the pore-scale morphology. For example, dissolved carbon dioxide may react with minerals in fractured rocks, confined aquifers, or faults, resulting in heterogeneous cementation (and/or dissolution) and evolving flow conditions. Both path and flow complexities are important and poorly characterized, making it difficult to determine their evolution with traditional 2-D transport models. Here we characterize the development of 3-D pore-scale flow with an evolving pore configuration due to calcium carbonate (CaCO3) precipitation and dissolution. A simple pattern of a microfluidic pore network is used initially and pore structures will become more complex due to precipitation and dissolution processes. At several stages of precipitation and dissolution, we directly visualize 3-D velocity vectors using micro particle image velocimetry and a laser scanning confocal microscope. Measured 3-D velocity vectors are then compared to 3-D simulated flow fields which will be used to simulate reactive transport. Our findings will highlight the importance of the 3-D flow dynamics and its impact on estimating reactive surface area over time. Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000. This material is based upon work supported as part of the Center for Frontiers of Subsurface Energy Security, an Energy Frontier Research Center funded by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Award Number DE-SC0001114.

  9. Waves of 3D marine structures slamming at different initial poses in complex wind-wave-flow environments

    NASA Astrophysics Data System (ADS)

    Zhu, Liang-sheng; Yu, Long-fei

    2016-10-01

    Aimed at the hydrodynamic response for marine structures slamming into water, based on the mechanism analysis to the slamming process, and by combining 3D N-S equation and k- ɛ turbulent kinetic equation with structure fully 6DOF motion equation, a mathematical model for the wind-fluid-solid interaction is established in 3D marine structure slamming wave at free poses and wind-wave-flow complex environments. Compared with the results of physical model test, the numerical results from the slamming wave well correspond with the experimental results. Through the mathematical model, the wave-making issue of 3D marine structure at initial pose falls into water in different complex wind, wave and flow environments is investigated. The research results show that various kinds of natural factors and structure initial poses have different influence on the slamming wave, and there is an obvious rule in this process.

  10. Investigation of gas-solids flow in a circulating fluidized bed using 3D electrical capacitance tomography

    NASA Astrophysics Data System (ADS)

    Mao, Mingxu; Ye, Jiamin; Wang, Haigang; Yang, Wuqiang

    2016-09-01

    The hydrodynamics of gas-solids flow in the bottom of a circulating fluidized bed (CFB) are complicated. Three-dimensional (3D) electrical capacitance tomography (ECT) has been used to investigate the hydrodynamics in risers of different shapes. Four different ECT sensors with 12 electrodes each are designed according to the dimension of risers, including two circular ECT sensors, a square ECT sensor and a rectangular ECT sensor. The electrodes are evenly arranged in three planes to obtain capacitance in different heights and to reconstruct the 3D images by linear back projection (LBP) algorithm. Experiments were carried out on the four risers using sands as the solids material. The capacitance and differential pressure are measured under the gas superficial velocity from 0.6 m s-1 to 3.0 m s-1 with a step of 0.2 m s-1. The flow regime is investigated according to the solids concentration and differential pressure. The dynamic property of bubbling flows is analyzed theoretically and the performance of the 3D ECT sensors is evaluated. The experimental results show that 3D ECT can be used in the CFB with different risers to predict the hydrodynamics of gas-solids bubbling flows.

  11. Programmable real-time applications with the 3D-Flow for input data rate systems of hundreds of MHz

    SciTech Connect

    Crosetto, D.

    1996-02-01

    The applicability of the 3D-Flow system to different experimental setups for real-time applications in the range of hundreds of nanoseconds is described. The results of the simulation of several real-time applications using the 3D-Flow demonstrate the advantages of a simple architecture that carries out operations in a balanced manner using regular connections and exceptionally few replicated components compared to conventional microprocessors. Diverse applications can be found that will benefit from this approach: High Energy Physics (HEP), which typically requires discerning patterns from thousands of accelerator particle collision signals up to 40 Mhz input data rate; Medical Imaging, that requires interactive tools for studying fast occurring biological processes; processing output from high-rate CCD cameras in commercial applications, such as quality control in manufacturing; data compression; speech and character recognition; automatic automobile guidance, and other applications. The 3D-Flow system was conceived for experiments at the Superconducting Super Collider (SSC). It was adopted by the Gamma Electron and Muon (GEM) experiment that was to be used for particle identification. The target of the 3D-Flow system was real-time pattern recognition at 100 million frames/sec.

  12. Investigation of gas–solids flow in a circulating fluidized bed using 3D electrical capacitance tomography

    NASA Astrophysics Data System (ADS)

    Mao, Mingxu; Ye, Jiamin; Wang, Haigang; Yang, Wuqiang

    2016-09-01

    The hydrodynamics of gas–solids flow in the bottom of a circulating fluidized bed (CFB) are complicated. Three-dimensional (3D) electrical capacitance tomography (ECT) has been used to investigate the hydrodynamics in risers of different shapes. Four different ECT sensors with 12 electrodes each are designed according to the dimension of risers, including two circular ECT sensors, a square ECT sensor and a rectangular ECT sensor. The electrodes are evenly arranged in three planes to obtain capacitance in different heights and to reconstruct the 3D images by linear back projection (LBP) algorithm. Experiments were carried out on the four risers using sands as the solids material. The capacitance and differential pressure are measured under the gas superficial velocity from 0.6 m s‑1 to 3.0 m s‑1 with a step of 0.2 m s‑1. The flow regime is investigated according to the solids concentration and differential pressure. The dynamic property of bubbling flows is analyzed theoretically and the performance of the 3D ECT sensors is evaluated. The experimental results show that 3D ECT can be used in the CFB with different risers to predict the hydrodynamics of gas–solids bubbling flows.

  13. SIMULATIONS OF 2D AND 3D THERMOCAPILLARY FLOWS BY A LEAST-SQUARES FINITE ELEMENT METHOD. (R825200)

    EPA Science Inventory

    Numerical results for time-dependent 2D and 3D thermocapillary flows are presented in this work. The numerical algorithm is based on the Crank-Nicolson scheme for time integration, Newton's method for linearization, and a least-squares finite element method, together with a matri...

  14. Multigrid preconditioned conjugate gradients for the numerical simulation of groundwater flow on the Cray T3D

    SciTech Connect

    Ashby, S.F.; Falgout, R.D.; Smith, S.G.; Fogwell, T.W.

    1994-09-01

    This paper discusses the numerical simulation of groundwater flow through heterogeneous porous media. The focus is on the performance of a parallel multigrid preconditioner for accelerating convergence of conjugate gradients, which is used to compute the hydraulic pressure head. The numerical investigation considers the effects of enlarging the domain, increasing the grid resolution, and varying the geostatistical parameters used to define the subsurface realization. The results were obtained using the PARFLOW groundwater flow simulator on the Cray T3D massively parallel computer.

  15. Comparison between measured turbine stage performance and the predicted performance using quasi-3D flow and boundary layer analyses

    NASA Technical Reports Server (NTRS)

    Boyle, R. J.; Haas, J. E.; Katsanis, T.

    1984-01-01

    A method for calculating turbine stage performance is described. The usefulness of the method is demonstrated by comparing measured and predicted efficiencies for nine different stages. Comparisons are made over a range of turbine pressure ratios and rotor speeds. A quasi-3D flow analysis is used to account for complex passage geometries. Boundary layer analyses are done to account for losses due to friction. Empirical loss models are used to account for incidence, secondary flow, disc windage, and clearance losses.

  16. Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matrices.

    PubMed

    Kim, Hyojin; Prasain, Nutan; Vemula, Sasidhar; Ferkowicz, Michael J; Yoshimoto, Momoko; Voytik-Harbin, Sherry L; Yoder, Mervin C

    2015-09-01

    Human cord blood (CB) is enriched in circulating endothelial colony forming cells (ECFCs) that display high proliferative potential and in vivo vessel forming ability. Since diminished ECFC survival is known to dampen the vasculogenic response in vivo, we tested how long implanted ECFC survive and generate vessels in three-dimensional (3D) type I collagen matrices in vitro and in vivo. We hypothesized that human platelet lysate (HPL) would promote cell survival and enhance vasculogenesis in the 3D collagen matrices. We report that the percentage of ECFC co-cultured with HPL that were alive was significantly enhanced on days 1 and 3 post-matrix formation, compared to ECFC alone containing matrices. Also, co-culture of ECFC with HPL displayed significantly more vasculogenic activity compared to ECFC alone and expressed significantly more pro-survival molecules (pAkt, p-Bad and Bcl-xL) in the 3D collagen matrices in vitro. Treatment with Akt1 inhibitor (A-674563), Akt2 inhibitor (CCT128930) and Bcl-xL inhibitor (ABT-263/Navitoclax) significantly decreased the cell survival and vasculogenesis of ECFC co-cultured with or without HPL and implicated activation of the Akt1 pathway as the critical mediator of the HPL effect on ECFC in vitro. A significantly greater average vessel number and total vascular area of human CD31(+) vessels were present in implants containing ECFC and HPL, compared to the ECFC alone implants in vivo. We conclude that implantation of ECFC with HPL in vivo promotes vasculogenesis and augments blood vessel formation via diminishing apoptosis of the implanted ECFC. PMID:26122935

  17. Intergrated 3-D Ground-Penetrating Radar,Outcrop,and Boreholoe Data Applied to Reservoir Characterization and Flow Simulation.

    SciTech Connect

    McMechan et al.

    2001-08-31

    Existing reservoir models are based on 2-D outcrop;3-D aspects are inferred from correlation between wells,and so are inadequately constrained for reservoir simulations. To overcome these deficiencies, we initiated a multidimensional characterization of reservoir analogs in the Cretaceous Ferron Sandstone in Utah.The study was conducted at two sites(Corbula Gulch Coyote Basin); results from both sites are contained in this report. Detailed sedimentary facies maps of cliff faces define the geometry and distribution of potential reservoir flow units, barriers and baffles at the outcrop. High resolution 2-D and 3-D ground penetrating radar(GPR) images extend these reservoir characteristics into 3-D to allow development of realistic 3-D reservoir models. Models use geometric information from the mapping and the GPR data, petrophysical data from surface and cliff-face outcrops, lab analyses of outcrop and core samples, and petrography. The measurements are all integrated into a single coordinate system using GPS and laser mapping of the main sedimentologic features and boundaries. The final step is analysis of results of 3-D fluid flow modeling to demonstrate applicability of our reservoir analog studies to well siting and reservoir engineering for maximization of hydrocarbon production. The main goals of this project are achieved. These are the construction of a deterministic 3-D reservoir analog model from a variety of geophysical and geologic measurements at the field sites, integrating these into comprehensive petrophysical models, and flow simulation through these models. This unique approach represents a significant advance in characterization and use of reservoir analogs. To data,the team has presented five papers at GSA and AAPG meetings produced a technical manual, and completed 15 technical papers. The latter are the main content of this final report. In addition,the project became part of 5 PhD dissertations, 3 MS theses,and two senior undergraduate research

  18. Integrated 3-D Ground-Penetrating Radar, Outcrop, and Borehole Data Applied to Reservoir Characterization and Flow Simulation

    SciTech Connect

    George McMechan; Rucsandra Corbeanu; Craig Forster; Kristian Soegaard; Xiaoxian Zeng; Carlos Aiken; Robert Szerbiak; Janok Bhattacharya; Michael Wizevich; Xueming Xu; Stephen Snelgrove; Karen Roche; Siang Joo Lim; Djuro Navakovic; Christopher White; Laura Crossey; Deming Wang; John Thurmond; William Hammon III; Mamadou BAlde; Ari Menitove

    2001-08-31

    OAK-B135 (IPLD Cleared) Existing reservoir models are based on 2-D outcrop studies; 3-D aspects are inferred from correlation between wells, and so are inadequately constrained for reservoir simulations. To overcome these deficiencies, we initiated a multidimensional characterization of reservoir analogs in the Cretaceous Ferron Sandstone in Utah. The study was conducted at two sites (Corbula Gulch and Coyote Basin); results from both sites are contained in this report. Detailed sedimentary facies maps of cliff faces define the geometry and distribution of potential reservoir flow units, barriers and baffles at the outcrop. High resolution 2-D and 3-D ground-penetrating radar (GPR) images extend these reservoir characteristics into 3-D, to allow development of realistic 3-D reservoir models. Models use geometric information from the mapping and the GPR data, petrophysical data from surface and cliff-face outcrops, lab analyses of outcrop and core samples, and petrography. The measurements are all integrated into a single coordinate system using GPS and laser mapping of the main sedimentological features and boundaries.The final step is analysis of results of 3-D fluid flow modeling to demonstrate applicability of our reservoir analog studies to well siting and reservoir engineering for maximization of hydrocarbon production. The main goals of the project are achieved. These are the construction of a deterministic 3-D reservoir analog model from a variety of geophysical and geologic measurements at the field sites, integrating these into comprehensive petrophysical models, and flow simulations through these models. This unique approach represents a significant advance in characterization and use of reservoir analogs.

  19. 3D CFD modeling of subsonic and transonic flowing-gas DPALs with different pumping geometries

    NASA Astrophysics Data System (ADS)

    Yacoby, Eyal; Sadot, Oren; Barmashenko, Boris D.; Rosenwaks, Salman

    2015-10-01

    Three-dimensional computational fluid dynamics (3D CFD) modeling of subsonic (Mach number M ~ 0.2) and transonic (M ~ 0.9) diode pumped alkali lasers (DPALs), taking into account fluid dynamics and kinetic processes in the lasing medium is reported. The performance of these lasers is compared with that of supersonic (M ~ 2.7 for Cs and M ~ 2.4 for K) DPALs. The motivation for this study stems from the fact that subsonic and transonic DPALs require much simpler hardware than supersonic ones where supersonic nozzle, diffuser and high power mechanical pump (due to a drop in the gas total pressure in the nozzle) are required for continuous closed cycle operation. For Cs DPALs with 5 x 5 cm2 flow cross section pumped by large cross section (5 x 2 cm2) beam the maximum achievable power of supersonic devices is higher than that of the transonic and subsonic devices by only ~ 3% and ~ 10%, respectively. Thus in this case the supersonic operation mode has no substantial advantage over the transonic one. The main processes limiting the power of Cs supersonic DPALs are saturation of the D2 transition and large ~ 60% losses of alkali atoms due to ionization, whereas the influence of gas heating is negligible. For K transonic DPALs both the gas heating and ionization effects are shown to be unimportant. The maximum values of the power are higher than those in Cs transonic laser by ~ 11%. The power achieved in the supersonic and transonic K DPAL is higher than for the subsonic version, with the same resonator and K density at the inlet, by ~ 84% and ~ 27%, respectively, showing a considerable advantaged of the supersonic device over the transonic one. For pumping by rectangular beams of the same (5 x 2 cm2) cross section, comparison between end-pumping - where the laser beam and pump beam both propagate at along the same axis, and transverse-pumping - where they propagate perpendicularly to each other, shows that the output power and optical-to-optical efficiency are not

  20. HEMP 3D -- a finite difference program for calculating elastic-plastic flow

    SciTech Connect

    Wilkins, M.L.

    1993-05-26

    The HEMP 3D program can be used to solve problems in solid mechanics involving dynamic plasticity and time dependent material behavior and problems in gas dynamics. The equations of motion, the conservation equations, and the constitutive relations are solved by finite difference methods following the format of the HEMP computer simulation program formulated in two space dimensions and time. Presented here is an update of the 1975 report on the HEMP 3D numerical technique. The present report includes the sliding surface routines programmed by Robert Gulliford.

  1. 2D fluid model analysis for the effect of 3D gas flow on a capacitively coupled plasma deposition reactor

    NASA Astrophysics Data System (ADS)

    Kim, Ho Jun; Lee, Hae June

    2016-06-01

    The wide applicability of capacitively coupled plasma (CCP) deposition has increased the interest in developing comprehensive numerical models, but CCP imposes a tremendous computational cost when conducting a transient analysis in a three-dimensional (3D) model which reflects the real geometry of reactors. In particular, the detailed flow features of reactive gases induced by 3D geometric effects need to be considered for the precise calculation of radical distribution of reactive species. Thus, an alternative inclusive method for the numerical simulation of CCP deposition is proposed to simulate a two-dimensional (2D) CCP model based on the 3D gas flow results by simulating flow, temperature, and species fields in a 3D space at first without calculating the plasma chemistry. A numerical study of a cylindrical showerhead-electrode CCP reactor was conducted for particular cases of SiH4/NH3/N2/He gas mixture to deposit a hydrogenated silicon nitride (SiN x H y ) film. The proposed methodology produces numerical results for a 300 mm wafer deposition reactor which agree very well with the deposition rate profile measured experimentally along the wafer radius.

  2. 3D flow visualization and tomographic particle image velocimetry for vortex breakdown over a non-slender delta wing

    NASA Astrophysics Data System (ADS)

    Wang, ChengYue; Gao, Qi; Wei, RunJie; Li, Tian; Wang, JinJun

    2016-06-01

    Volumetric measurement for the leading-edge vortex (LEV) breakdown of a delta wing has been conducted by three-dimensional (3D) flow visualization and tomographic particle image velocimetry (TPIV). The 3D flow visualization is employed to show the vortex structures, which was recorded by four cameras with high resolution. 3D dye streaklines of the visualization are reconstructed using a similar way of particle reconstruction in TPIV. Tomographic PIV is carried out at the same time using same cameras with the dye visualization. Q criterion is employed to identify the LEV. Results of tomographic PIV agree well with the reconstructed 3D dye streaklines, which proves the validity of the measurements. The time-averaged flow field based on TPIV is shown and described by sections of velocity and streamwise vorticity. Combining the two measurement methods sheds light on the complex structures of both bubble type and spiral type of breakdown. The breakdown position is recognized by investigating both the streaklines and TPIV velocity fields. Proper orthogonal decomposition is applied to extract a pair of conjugated helical instability modes from TPIV data. Therefore, the dominant frequency of the instability modes is obtained from the corresponding POD coefficients of the modes based on wavelet transform analysis.

  3. Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip.

    PubMed

    Herland, Anna; van der Meer, Andries D; FitzGerald, Edward A; Park, Tae-Eun; Sleeboom, Jelle J F; Ingber, Donald E

    2016-01-01

    Neurovascular inflammation is a major contributor to many neurological disorders, but modeling these processes in vitro has proven to be difficult. Here, we microengineered a three-dimensional (3D) model of the human blood-brain barrier (BBB) within a microfluidic chip by creating a cylindrical collagen gel containing a central hollow lumen inside a microchannel, culturing primary human brain microvascular endothelial cells on the gel's inner surface, and flowing medium through the lumen. Studies were carried out with the engineered microvessel containing endothelium in the presence or absence of either primary human brain pericytes beneath the endothelium or primary human brain astrocytes within the surrounding collagen gel to explore the ability of this simplified model to identify distinct contributions of these supporting cells to the neuroinflammatory response. This human 3D BBB-on-a-chip exhibited barrier permeability similar to that observed in other in vitro BBB models created with non-human cells, and when stimulated with the inflammatory trigger, tumor necrosis factor-alpha (TNF-α), different secretion profiles for granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) were observed depending on the presence of astrocytes or pericytes. Importantly, the levels of these responses detected in the 3D BBB chip were significantly greater than when the same cells were co-cultured in static Transwell plates. Thus, as G-CSF and IL-6 have been reported to play important roles in neuroprotection and neuroactivation in vivo, this 3D BBB chip potentially offers a new method to study human neurovascular function and inflammation in vitro, and to identify physiological contributions of individual cell types.

  4. Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

    PubMed Central

    FitzGerald, Edward A.; Park, Tae-Eun; Sleeboom, Jelle J. F.; Ingber, Donald E.

    2016-01-01

    Neurovascular inflammation is a major contributor to many neurological disorders, but modeling these processes in vitro has proven to be difficult. Here, we microengineered a three-dimensional (3D) model of the human blood-brain barrier (BBB) within a microfluidic chip by creating a cylindrical collagen gel containing a central hollow lumen inside a microchannel, culturing primary human brain microvascular endothelial cells on the gel’s inner surface, and flowing medium through the lumen. Studies were carried out with the engineered microvessel containing endothelium in the presence or absence of either primary human brain pericytes beneath the endothelium or primary human brain astrocytes within the surrounding collagen gel to explore the ability of this simplified model to identify distinct contributions of these supporting cells to the neuroinflammatory response. This human 3D BBB-on-a-chip exhibited barrier permeability similar to that observed in other in vitro BBB models created with non-human cells, and when stimulated with the inflammatory trigger, tumor necrosis factor-alpha (TNF-α), different secretion profiles for granulocyte colony-stimulating factor (G-CSF) and interleukin-6 (IL-6) were observed depending on the presence of astrocytes or pericytes. Importantly, the levels of these responses detected in the 3D BBB chip were significantly greater than when the same cells were co-cultured in static Transwell plates. Thus, as G-CSF and IL-6 have been reported to play important roles in neuroprotection and neuroactivation in vivo, this 3D BBB chip potentially offers a new method to study human neurovascular function and inflammation in vitro, and to identify physiological contributions of individual cell types. PMID:26930059

  5. A prediction of 3-D viscous flow and performance of the NASA low-speed centrifugal compressor

    NASA Technical Reports Server (NTRS)

    Moore, John; Moore, Joan G.

    1989-01-01

    A prediction of the 3-D turbulent flow in the NASA Low-Speed Centrifugal Compressor Impeller has been made. The calculation was made for the compressor design conditions with the specified uniform tip clearance gap. The predicted performance is significantly worse than that predicted in the NASA design study. This is explained by the high tip leakage flow in the present calculation and by the different model adopted for tip leakage flow mixing. The calculation gives an accumulation for high losses in the shroud/pressure-side quadrant near the exit of the impeller. It also predicts a region of meridional backflow near the shroud wall. Both of these flow features should be extensive enough in the NASA impeller to allow detailed flow measurements, leading to improved flow modelling. Recommendations are made for future flow studies in the NASA impeller.

  6. Measurement of particle trajectories, dynamics, surface adhesion and detachment in near-wall shear flows using 3D velocimetry

    NASA Astrophysics Data System (ADS)

    Guasto, Jeffrey; Schmidt, Brian; Lawrence, Michael; Breuer, Kenneth

    2007-11-01

    Three-dimensional total internal reflection velocimetry (3D-TIRV) is used to measure the trajectories of fluorescent tracer particles within 200 nm of a wall. Diffusion and shear-induced motion can result in mean velocity measurement errors, and by taking measurements using different particle sizes and sampling times, we quantify these effects and compare with theory. We also use 3D-TIRV to observe and characterize the adhesion, surface rolling and release dynamics of particles that can adhere to the surface through the action of biological binding proteins. Particles coated with P-Selectin are allowed to adhere to and detach from a PSGL-1-coated microchannel surface, modeling the interaction between leukocytes (white blood cells) and blood vessels, respectively. Binding affinities, bond strengths and hydrodynamic interactions are inferred from the trajectory data.

  7. A reconstruction method of intra-ventricular blood flow using color flow ultrasound: a simulation study

    NASA Astrophysics Data System (ADS)

    Jang, Jaeseong; Ahn, Chi Young; Jeon, Kiwan; Choi, Jung-il; Lee, Changhoon; Seo, Jin Keun

    2015-03-01

    A reconstruction method is proposed here to quantify the distribution of blood flow velocity fields inside the left ventricle from color Doppler echocardiography measurement. From 3D incompressible Navier- Stokes equation, a 2D incompressible Navier-Stokes equation with a mass source term is derived to utilize the measurable color flow ultrasound data in a plane along with the moving boundary condition. The proposed model reflects out-of-plane blood flows on the imaging plane through the mass source term. For demonstrating a feasibility of the proposed method, we have performed numerical simulations of the forward problem and numerical analysis of the reconstruction method. First, we construct a 3D moving LV region having a specific stroke volume. To obtain synthetic intra-ventricular flows, we performed a numerical simulation of the forward problem of Navier-Stokes equation inside the 3D moving LV, computed 3D intra-ventricular velocity fields as a solution of the forward problem, projected the 3D velocity fields on the imaging plane and took the inner product of the 2D velocity fields on the imaging plane and scanline directional velocity fields for synthetic scanline directional projected velocity at each position. The proposed method utilized the 2D synthetic projected velocity data for reconstructing LV blood flow. By computing the difference between synthetic flow and reconstructed flow fields, we obtained the averaged point-wise errors of 0.06 m/s and 0.02 m/s for u- and v-components, respectively.

  8. Massively Parallel Linear Stability Analysis with P_ARPACK for 3D Fluid Flow Modeled with MPSalsa

    SciTech Connect

    Lehoucq, R.B.; Salinger, A.G.

    1998-10-13

    We are interested in the stability of three-dimensional fluid flows to small dkturbances. One computational approach is to solve a sequence of large sparse generalized eigenvalue problems for the leading modes that arise from discretizating the differential equations modeling the flow. The modes of interest are the eigenvalues of largest real part and their associated eigenvectors. We discuss our work to develop an effi- cient and reliable eigensolver for use by the massively parallel simulation code MPSalsa. MPSalsa allows simulation of complex 3D fluid flow, heat transfer, and mass transfer with detailed bulk fluid and surface chemical reaction kinetics.

  9. 3-D viscous flow CFD analysis of the propeller effect on an advanced ducted propeller subsonic inlet

    NASA Technical Reports Server (NTRS)

    Iek, Chanthy; Boldman, Donald R.; Ibrahim, Mounir

    1993-01-01

    The time-marching Navier-Stokes code PARC3D was used to study the 3D viscous flow associated with an advanced ducted propeller subsonic inlet at take-off operating conditions. At a free stream Mach number of 0.2, experimental data for the inlet-with-propeller test model indicated that the airflow was attached on the cowl windward lip at an angle of attack of 25 deg became unstable at 29 deg, and separated at 30 deg. An experimental study with a similar inlet and without propeller (through-flow) indicated that flow separation occurred at an angle of attack a few degrees below the value observed when the inlet was tested with the propeller, indicating the propeller's favorable effect on inlet performance. In the present numerical study, flow blockage analogous to the propeller was modeled via a PARC3D computational boundary condition (BC), the 'screen BC', based on 1-1/2 dimension actuator disk theory. The application of the screen BC in this numerical study provided results similar to those of past experimental efforts in which either the blockage device or the propeller was used.

  10. Structure-function studies of blood and air capillaries in chicken lung using 3D electron microscopy.

    PubMed

    West, John B; Fu, Zhenxing; Deerinck, Thomas J; Mackey, Mason R; Obayashi, James T; Ellisman, Mark H

    2010-02-28

    Avian pulmonary capillaries differ from those of mammals in three important ways. The blood-gas barrier is much thinner, it is more uniform in thickness, and the capillaries are far more rigid when their transmural pressure is altered. The thinness of the barrier is surprising because it predisposes the capillaries to stress failure. A possible mechanism for these differences is that avian pulmonary capillaries, unlike mammalian, are supported from the outside by air capillaries, but the details of the support are poorly understood. To clarify this we studied the blood and air capillaries in chicken lung using transmission electron microscopy (EM) and two relatively new techniques that allow 3D visualization: electron tomography and serial block-face scanning EM. These studies show that the pulmonary capillaries are flanked by epithelial bridges composed of two extremely thin epithelial cells with large surface areas. The junctions of the bridges with the capillary walls show thickening of the epithelial cells and an accumulation of extracellular matrix. Collapse of the pulmonary capillaries when the pressure outside them is increased is apparently prevented by the guy wire-like action of the epithelial bridges. The enlarged junctions between the bridges and the walls could provide a mechanism that limits the hoop stress in the capillary walls when the pressure inside them is increased. The support of the pulmonary capillaries may also be explained by an interdependence mechanism whereby the capillaries are linked to a rigid assemblage of air capillaries. These EM studies show the supporting structures in greater detail than has previously been possible, particularly in 3D, and they allow a more complete analysis of the mechanical forces affecting avian pulmonary capillaries. PMID:20038456

  11. Validation of Perfusion Quantification with 3D Gradient Echo Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Blood Pool Contrast Agent in Skeletal Swine Muscle

    PubMed Central

    Hindel, Stefan; Sauerbrey, Anika; Maaß, Marc; Maderwald, Stefan; Schlamann, Marc; Lüdemann, Lutz

    2015-01-01

    The purpose of our study was to validate perfusion quantification in a low-perfused tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with shared k-space sampling using a blood pool contrast agent. Perfusion measurements were performed in a total of seven female pigs. An ultrasonic Doppler probe was attached to the right femoral artery to determine total flow in the hind leg musculature. The femoral artery was catheterized for continuous local administration of adenosine to increase blood flow up to four times the baseline level. Three different stable perfusion levels were induced. The MR protocol included a 3D gradient-echo sequence with a temporal resolution of approximately 1.5 seconds. Before each dynamic sequence, static MR images were acquired with flip angles of 5°, 10°, 20°, and 30°. Both static and dynamic images were used to generate relaxation rate and baseline magnetization maps with a flip angle method. 0.1 mL/kg body weight of blood pool contrast medium was injected via a central venous catheter at a flow rate of 5 mL/s. The right hind leg was segmented in 3D into medial, cranial, lateral, and pelvic thigh muscles, lower leg, bones, skin, and fat. The arterial input function (AIF) was measured in the aorta. Perfusion of the different anatomic regions was calculated using a one- and a two-compartment model with delay- and dispersion-corrected AIFs. The F-test for model comparison was used to decide whether to use the results of the one- or two-compartment model fit. Total flow was calculated by integrating volume-weighted perfusion values over the whole measured region. The resulting values of delay, dispersion, blood volume, mean transit time, and flow were all in physiologically and physically reasonable ranges. In 107 of 160 ROIs, the blood signal was separated, using a two-compartment model, into a capillary and an arteriolar signal contribution, decided by the F-test. Overall flow in hind leg muscles, as measured by the

  12. Validation of Perfusion Quantification with 3D Gradient Echo Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Blood Pool Contrast Agent in Skeletal Swine Muscle.

    PubMed

    Hindel, Stefan; Sauerbrey, Anika; Maaß, Marc; Maderwald, Stefan; Schlamann, Marc; Lüdemann, Lutz

    2015-01-01

    The purpose of our study was to validate perfusion quantification in a low-perfused tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with shared k-space sampling using a blood pool contrast agent. Perfusion measurements were performed in a total of seven female pigs. An ultrasonic Doppler probe was attached to the right femoral artery to determine total flow in the hind leg musculature. The femoral artery was catheterized for continuous local administration of adenosine to increase blood flow up to four times the baseline level. Three different stable perfusion levels were induced. The MR protocol included a 3D gradient-echo sequence with a temporal resolution of approximately 1.5 seconds. Before each dynamic sequence, static MR images were acquired with flip angles of 5°, 10°, 20°, and 30°. Both static and dynamic images were used to generate relaxation rate and baseline magnetization maps with a flip angle method. 0.1 mL/kg body weight of blood pool contrast medium was injected via a central venous catheter at a flow rate of 5 mL/s. The right hind leg was segmented in 3D into medial, cranial, lateral, and pelvic thigh muscles, lower leg, bones, skin, and fat. The arterial input function (AIF) was measured in the aorta. Perfusion of the different anatomic regions was calculated using a one- and a two-compartment model with delay- and dispersion-corrected AIFs. The F-test for model comparison was used to decide whether to use the results of the one- or two-compartment model fit. Total flow was calculated by integrating volume-weighted perfusion values over the whole measured region. The resulting values of delay, dispersion, blood volume, mean transit time, and flow were all in physiologically and physically reasonable ranges. In 107 of 160 ROIs, the blood signal was separated, using a two-compartment model, into a capillary and an arteriolar signal contribution, decided by the F-test. Overall flow in hind leg muscles, as measured by the

  13. Validation of Perfusion Quantification with 3D Gradient Echo Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using a Blood Pool Contrast Agent in Skeletal Swine Muscle.

    PubMed

    Hindel, Stefan; Sauerbrey, Anika; Maaß, Marc; Maderwald, Stefan; Schlamann, Marc; Lüdemann, Lutz

    2015-01-01

    The purpose of our study was to validate perfusion quantification in a low-perfused tissue by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with shared k-space sampling using a blood pool contrast agent. Perfusion measurements were performed in a total of seven female pigs. An ultrasonic Doppler probe was attached to the right femoral artery to determine total flow in the hind leg musculature. The femoral artery was catheterized for continuous local administration of adenosine to increase blood flow up to four times the baseline level. Three different stable perfusion levels were induced. The MR protocol included a 3D gradient-echo sequence with a temporal resolution of approximately 1.5 seconds. Before each dynamic sequence, static MR images were acquired with flip angles of 5°, 10°, 20°, and 30°. Both static and dynamic images were used to generate relaxation rate and baseline magnetization maps with a flip angle method. 0.1 mL/kg body weight of blood pool contrast medium was injected via a central venous catheter at a flow rate of 5 mL/s. The right hind leg was segmented in 3D into medial, cranial, lateral, and pelvic thigh muscles, lower leg, bones, skin, and fat. The arterial input function (AIF) was measured in the aorta. Perfusion of the different anatomic regions was calculated using a one- and a two-compartment model with delay- and dispersion-corrected AIFs. The F-test for model comparison was used to decide whether to use the results of the one- or two-compartment model fit. Total flow was calculated by integrating volume-weighted perfusion values over the whole measured region. The resulting values of delay, dispersion, blood volume, mean transit time, and flow were all in physiologically and physically reasonable ranges. In 107 of 160 ROIs, the blood signal was separated, using a two-compartment model, into a capillary and an arteriolar signal contribution, decided by the F-test. Overall flow in hind leg muscles, as measured by the

  14. Some potential blood flow experiments for space

    NASA Technical Reports Server (NTRS)

    Cokelet, G. R.; Meiselman, H. J.; Goldsmith, H. L.

    1979-01-01

    Blood is a colloidal suspension of cells, predominantly erythrocytes, (red cells) in an aqueous solution called plasma. Because the red cells are more dense than the plasma, and because they tend to aggregate, erythrocyte sedimentation can be significant when the shear stresses in flowing blood are small. This behavior, coupled with equipment restrictions, has prevented certain definitive fluid mechanical studies from being performed with blood in ground-based experiments. Among such experiments, which could be satisfactorily performed in a microgravity environment, are the following: (1) studies of blood flow in small tubes, to obtain pressure-flow rate relationships, to determine if increased red cell aggregation can be an aid to blood circulation, and to determine vessel entrance lengths, and (2) studies of blood flow through vessel junctions (bifurcations), to obtain information on cell distribution in downstream vessels of (arterial) bifurcations, and to test flow models of stratified convergent blood flows downstream from (venous) bifurcations.

  15. Fast particles identification in programmable form at level-0 trigger by means of the 3D-Flow system

    SciTech Connect

    Crosetto, Dario B.

    1998-10-30

    The 3D-Flow Processor system is a new, technology-independent concept in very fast, real-time system architectures. Based on either an FPGA or an ASIC implementation, it can address, in a fully programmable manner, applications where commercially available processors would fail because of throughput requirements. Possible applications include filtering-algorithms (pattern recognition) from the input of multiple sensors, as well as moving any input validated by these filtering-algorithms to a single output channel. Both operations can easily be implemented on a 3D-Flow system to achieve a real-time processing system with a very short lag time. This system can be built either with off-the-shelf FPGAs or, for higher data rates, with CMOS chips containing 4 to 16 processors each. The basic building block of the system, a 3D-Flow processor, has been successfully designed in VHDL code written in ''Generic HDL'' (mostly made of reusable blocks that are synthesizable in different technologies, or FPGAs), to produce a netlist for a four-processor ASIC featuring 0.35 micron CBA (Ceil Base Array) technology at 3.3 Volts, 884 mW power dissipation at 60 MHz and 63.75 mm sq. die size. The same VHDL code has been targeted to three FPGA manufacturers (Altera EPF10K250A, ORCA-Lucent Technologies 0R3T165 and Xilinx XCV1000). A complete set of software tools, the 3D-Flow System Manager, equally applicable to ASIC or FPGA implementations, has been produced to provide full system simulation, application development, real-time monitoring, and run-time fault recovery. Today's technology can accommodate 16 processors per chip in a medium size die, at a cost per processor of less than $5 based on the current silicon die/size technology cost.

  16. Plane shear flows of frictionless spheres: Kinetic theory and 3D soft-sphere discrete element method simulations

    SciTech Connect

    Vescovi, D.; Berzi, D.; Richard, P.

    2014-05-15

    We use existing 3D Discrete Element simulations of simple shear flows of spheres to evaluate the radial distribution function at contact that enables kinetic theory to correctly predict the pressure and the shear stress, for different values of the collisional coefficient of restitution. Then, we perform 3D Discrete Element simulations of plane flows of frictionless, inelastic spheres, sheared between walls made bumpy by gluing particles in a regular array, at fixed average volume fraction and distance between the walls. The results of the numerical simulations are used to derive boundary conditions appropriated in the cases of large and small bumpiness. Those boundary conditions are, then, employed to numerically integrate the differential equations of Extended Kinetic Theory, where the breaking of the molecular chaos assumption at volume fraction larger than 0.49 is taken into account in the expression of the dissipation rate. We show that the Extended Kinetic Theory is in very good agreement with the numerical simulations, even for coefficients of restitution as low as 0.50. When the bumpiness is increased, we observe that some of the flowing particles are stuck in the gaps between the wall spheres. As a consequence, the walls are more dissipative than expected, and the flows resemble simple shear flows, i.e., flows of rather constant volume fraction and granular temperature.

  17. Quasi 3D modeling of water flow in vadose zone and groundwater

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The complexity of subsurface flow systems calls for a variety of concepts leading to the multiplicity of simplified flow models. One habitual simplification is based on the assumption that lateral flow and transport in unsaturated zone are not significant unless the capillary fringe is involved. In ...

  18. A low order flow/acoustics interaction method for the prediction of sound propagation using 3D adaptive hybrid grids

    SciTech Connect

    Kallinderis, Yannis; Vitsas, Panagiotis A.; Menounou, Penelope

    2012-07-15

    A low-order flow/acoustics interaction method for the prediction of sound propagation and diffraction in unsteady subsonic compressible flow using adaptive 3-D hybrid grids is investigated. The total field is decomposed into the flow field described by the Euler equations, and the acoustics part described by the Nonlinear Perturbation Equations. The method is shown capable of predicting monopole sound propagation, while employment of acoustics-guided adapted grid refinement improves the accuracy of capturing the acoustic field. Interaction of sound with solid boundaries is also examined in terms of reflection, and diffraction. Sound propagation through an unsteady flow field is examined using static and dynamic flow/acoustics coupling demonstrating the importance of the latter.

  19. An axis-free overset grid in spherical polar coordinates for simulating 3D self-gravitating flows

    NASA Astrophysics Data System (ADS)

    Wongwathanarat, A.; Hammer, N. J.; Müller, E.

    2010-05-01

    Aims: Three dimensional explicit hydrodynamic codes based on spherical polar coordinates using a single spherical polar grid suffer from a severe restriction of the time step size due to the convergence of grid lines near the poles of the coordinate system. More importantly, numerical artifacts are encountered at the symmetry axis of the grid where boundary conditions have to be imposed that flaw the flow near the axis. The first problem can be eased and the second one avoided by applying an overlapping grid technique. Methods: A type of overlapping grid in spherical coordinates is adopted. This so called “Yin-Yang” grid is a two-patch overset grid proposed by Kageyama and Sato for geophysical simulations. Its two grid patches contain only the low-latitude regions of the usual spherical polar grid and are combined together in a simple manner. This property of the Yin-Yang grid greatly simplifies its implementation into a 3D code already employing spherical polar coordinates. It further allows for a much larger time step in 3D simulations using high angular resolution (⪉1°) than that required in 3D simulations using a regular spherical grid with the same angular resolution. Results: The Yin-Yang grid is successfully implemented into a 3D version of the explicit Eulerian grid-based code PROMETHEUS including self-gravity. The modified code successfully passed several standard hydrodynamic tests producing results which are in very good agreement with analytic solutions. Moreover, the solutions obtained with the Yin-Yang grid exhibit no peculiar behaviour at the boundary between the two grid patches. The code has also been successfully used to model astrophysically relevant situations, namely equilibrium polytropes, a Taylor-Sedov explosion, and Rayleigh-Taylor instabilities. According to our results, the usage of the Yin-Yang grid greatly enhances the suitability and efficiency of 3D explicit Eulerian codes based on spherical polar coordinates for astrophysical

  20. Influence of surface roughness on nonlinear flow behaviors in 3D self-affine rough fractures: Lattice Boltzmann simulations

    NASA Astrophysics Data System (ADS)

    Wang, Min; Chen, Yi-Feng; Ma, Guo-Wei; Zhou, Jia-Qing; Zhou, Chuang-Bing

    2016-10-01

    This study investigates the impacts of surface roughness on the nonlinear fluid flow through three-dimensional (3D) self-affine rock fractures, whose original surface roughness is decomposed into primary roughness (i.e. the large-scale waviness of the fracture morphology) and secondary roughness (i.e. the small-scale unevenness) with a wavelet analysis technique. A 3D Lattice Boltzmann method (LBM) is adopted to predict the flow physics in rock fractures numerically created with and without consideration of the secondary roughness, respectively. The simulation results show that the primary roughness mostly controls the pressure distribution and fracture flow paths at a large scale, whereas the secondary roughness determines the nonlinear properties of the fluid flow at a local scale. As the pressure gradient increases, the secondary roughness enhances the local complexity of velocity distribution by generating and expanding the eddy flow and back flow regions in the vicinity of asperities. It was found that the Forchheimer's law characterizes well the nonlinear flow behavior in fractures of varying roughness. The inertial effects induced by the primary roughness differ only marginally in fractures with the roughness exponent varying from 0.5 to 0.8, and it is the secondary roughness that significantly enhances the nonlinear flow and leads to earlier onset of nonlinearity. Further examined were the effects of surface roughness on the transmissivity, hydraulic aperture and the tortuosity of flow paths, demonstrating again the dominant role of the secondary roughness, especially for the apparent transmissivity and the equivalent hydraulic aperture at high pressure gradient or high Reynolds number. The results may enhance our understanding of the role of surface roughness in the nonlinear flow behaviors in natural rock fractures.

  1. The 3-D viscous flow CFD analysis of the propeller effect on an advanced ducted propeller subsonic inlet

    NASA Technical Reports Server (NTRS)

    Iek, Chanthy; Boldman, Donald R.; Ibrahim, Mounir

    1993-01-01

    A time marching Navier-Stokes code called PARC3D was used to study the 3-D viscous flow associated with an advanced ducted propeller (ADP) subsonic inlet at take-off operating conditions. At a free stream Mach number of 0.2, experimental data for the inlet-with-propeller test model indicated that the airflow was attached on the cowl windward lip at an angle of attack of 25 degrees became unstable at 29 degrees, and separated at 30 degrees. An experimental study with a similar inlet and with no propeller (through-flow) indicated that flow separation occurred at an angle of attack a few degrees below the value observed when the inlet was tested with the propeller. This tends to indicate that the propeller exerts a favorable effect on the inlet performance. During the through-flow experiment a stationary blockage device was used to successfully simulate the propeller effect on the inlet flow field at angles of attack. In the present numerical study, this flow blockage was modeled via a PARC3D computational boundary condition (BC) called the screen BC. The principle formulation of this BC was based on the one-and-half dimension actuator disk theory. This screen BC was applied at the inlet propeller face station of the computational grid. Numerical results were obtained with and without the screen BC. The application of the screen BC in this numerical study provided results which are similar to the results of past experimental efforts in which either the blockage device or the propeller was used.

  2. Cutaneous blood flow in psoriasis

    SciTech Connect

    Klemp, P.; Staberg, B.

    1983-12-01

    The disappearance rate of /sup 133/Xe was studied in 20 patients with psoriasis vulgaris, using an epicutaneous labeling technique in involved skin lesions or normal-appearing skin of the proximal extensor site of the forearm. Control experiments were performed in 10 normal subjects. Calculations of the cutaneous blood flow (CBF) in psoriatic skin lesions were performed using a tissue-to-blood partition coefficient for /sup 133/Xe, lambda c,pso, of 1.2 ml/100 g/min. lambda c,pso was estimated after the relative content of water, lipids, and proteins had been analyzed in psoriatic skin biopsies of 6 patients with untreated psoriasis. The mean relative content of water was markedly reduced to 23.5 +/- 1.5% (SEM), and lipids and proteins were markedly increased to 2.5 +/- 0.7% and 74.0 +/- 2.2, respectively, compared to previously published data for normal skin (water 72.5%, lipids 1%, proteins 26.5%). Mean CBF in untreated psoriatic skin was 63.5 +/- 9.0 ml/100 g/min. This was significantly higher than the mean CBF in 10 normal subjects, 6.3 +/- 0.5 ml/100 g/min (p much less than 0.0001). Mean CBF in normal-appearing skin in patients with psoriasis was 11.0 +/- 1.3 ml/100 g/min. This was significantly higher than CBF in normal subjects (p less than 0.0002).

  3. 3-D flow and scour near a submerged wing dike: ADCP measurements on the Missouri River

    USGS Publications Warehouse

    Jamieson, E.C.; Rennie, C.D.; Jacobson, R.B.; Townsend, R.D.

    2011-01-01

    Detailed mapping of bathymetry and three-dimensional water velocities using a boat-mounted single-beam sonar and acoustic Doppler current profiler (ADCP) was carried out in the vicinity of two submerged wing dikes located in the Lower Missouri River near Columbia, Missouri. During high spring flows the wing dikes become submerged, creating a unique combination of vertical flow separation and overtopping (plunging) flow conditions, causing large-scale three-dimensional turbulent flow structures to form. On three different days and for a range of discharges, sampling transects at 5 and 20 m spacing were completed, covering the area adjacent to and upstream and downstream from two different wing dikes. The objectives of this research are to evaluate whether an ADCP can identify and measure large-scale flow features such as recirculating flow and vortex shedding that develop in the vicinity of a submerged wing dike; and whether or not moving-boat (single-transect) data are sufficient for resolving complex three-dimensional flow fields. Results indicate that spatial averaging from multiple nearby single transects may be more representative of an inherently complex (temporally and spatially variable) three-dimensional flow field than repeated single transects. Results also indicate a correspondence between the location of calculated vortex cores (resolved from the interpolated three-dimensional flow field) and the nearby scour holes, providing new insight into the connections between vertically oriented coherent structures and local scour, with the unique perspective of flow and morphology in a large river.

  4. Holographic intravital microscopy for 2-D and 3-D imaging intact circulating blood cells in microcapillaries of live mice.

    PubMed

    Kim, Kyoohyun; Choe, Kibaek; Park, Inwon; Kim, Pilhan; Park, YongKeun

    2016-01-01

    Intravital microscopy is an essential tool that reveals behaviours of live cells under conditions close to natural physiological states. So far, although various approaches for imaging cells in vivo have been proposed, most require the use of labelling and also provide only qualitative imaging information. Holographic imaging approach based on measuring the refractive index distributions of cells, however, circumvent these problems and offer quantitative and label-free imaging capability. Here, we demonstrate in vivo two- and three-dimensional holographic imaging of circulating blood cells in intact microcapillaries of live mice. The measured refractive index distributions of blood cells provide morphological and biochemical properties including three-dimensional cell shape, haemoglobin concentration, and haemoglobin contents at the individual cell level. With the present method, alterations in blood flow dynamics in live healthy and sepsis-model mice were also investigated.

  5. Holographic intravital microscopy for 2-D and 3-D imaging intact circulating blood cells in microcapillaries of live mice

    NASA Astrophysics Data System (ADS)

    Kim, Kyoohyun; Choe, Kibaek; Park, Inwon; Kim, Pilhan; Park, Yongkeun

    2016-09-01

    Intravital microscopy is an essential tool that reveals behaviours of live cells under conditions close to natural physiological states. So far, although various approaches for imaging cells in vivo have been proposed, most require the use of labelling and also provide only qualitative imaging information. Holographic imaging approach based on measuring the refractive index distributions of cells, however, circumvent these problems and offer quantitative and label-free imaging capability. Here, we demonstrate in vivo two- and three-dimensional holographic imaging of circulating blood cells in intact microcapillaries of live mice. The measured refractive index distributions of blood cells provide morphological and biochemical properties including three-dimensional cell shape, haemoglobin concentration, and haemoglobin contents at the individual cell level. With the present method, alterations in blood flow dynamics in live healthy and sepsis-model mice were also investigated.

  6. Holographic intravital microscopy for 2-D and 3-D imaging intact circulating blood cells in microcapillaries of live mice

    PubMed Central

    Kim, Kyoohyun; Choe, Kibaek; Park, Inwon; Kim, Pilhan; Park, YongKeun

    2016-01-01

    Intravital microscopy is an essential tool that reveals behaviours of live cells under conditions close to natural physiological states. So far, although various approaches for imaging cells in vivo have been proposed, most require the use of labelling and also provide only qualitative imaging information. Holographic imaging approach based on measuring the refractive index distributions of cells, however, circumvent these problems and offer quantitative and label-free imaging capability. Here, we demonstrate in vivo two- and three-dimensional holographic imaging of circulating blood cells in intact microcapillaries of live mice. The measured refractive index distributions of blood cells provide morphological and biochemical properties including three-dimensional cell shape, haemoglobin concentration, and haemoglobin contents at the individual cell level. With the present method, alterations in blood flow dynamics in live healthy and sepsis-model mice were also investigated. PMID:27605489

  7. Holographic intravital microscopy for 2-D and 3-D imaging intact circulating blood cells in microcapillaries of live mice.

    PubMed

    Kim, Kyoohyun; Choe, Kibaek; Park, Inwon; Kim, Pilhan; Park, YongKeun

    2016-01-01

    Intravital microscopy is an essential tool that reveals behaviours of live cells under conditions close to natural physiological states. So far, although various approaches for imaging cells in vivo have been proposed, most require the use of labelling and also provide only qualitative imaging information. Holographic imaging approach based on measuring the refractive index distributions of cells, however, circumvent these problems and offer quantitative and label-free imaging capability. Here, we demonstrate in vivo two- and three-dimensional holographic imaging of circulating blood cells in intact microcapillaries of live mice. The measured refractive index distributions of blood cells provide morphological and biochemical properties including three-dimensional cell shape, haemoglobin concentration, and haemoglobin contents at the individual cell level. With the present method, alterations in blood flow dynamics in live healthy and sepsis-model mice were also investigated. PMID:27605489

  8. Blood Cell Interactions and Segregation in Flow

    PubMed Central

    Munn, Lance L.; Dupin, Michael M.

    2009-01-01

    For more than a century, pioneering researchers have been using novel experimental and computational approaches to probe the mysteries of blood flow. Thanks to their efforts, we know that blood cells generally prefer to migrate to the axis of flow, that red and white cells segregate in flow, and that cell deformability and their tendency to reversibly aggregate contribute to the non-Newtonian nature of this unique fluid. All of these properties have beneficial physiological consequences, allowing blood to perform a variety of critical functions. Our current understanding of these unusual flow properties of blood have been made possible by the ingenuity and diligence of a number of researchers, including Harry Goldsmith, who developed novel technologies to visualize and quantify the flow of blood at the level of individual cells. Here we summarize efforts in our lab to continue this tradition and to further our understanding of how blood cells interact with each other and with the blood vessel wall. PMID:18188702

  9. 3D tomographic reconstruction of the internal velocity field of an immiscible drop in a shear flow

    NASA Astrophysics Data System (ADS)

    Kerdraon, Paul; Dalziel, Stuart B.; Goldstein, Raymond E.; Landel, Julien R.; Peaudecerf, Francois J.

    2015-11-01

    We study experimentally the internal flow of a drop attached to a flat substrate and immersed in an immiscible shear flow. Transport inside the drop can play a crucial role in cleaning applications. Internal advection can enhance the mass transfer across the drop surface, thus increasing the cleaning rate. We used microlitre water-glycerol drops on a hydrophobic substrate. The drops were spherical and did not deform significantly under the shear flow. An oil phase of relative viscosity 0.01 to 1 was flowed over the drop. Typical Reynolds numbers inside the drops were of the order of 0.1 to 10. Using confocal microscopy, we performed 3D tomographic reconstruction of the flow field in the drop. The in-plane velocity field was measured using micro-PIV, and the third velocity component was computed from incompressibility. To our knowledge, this study gives the first experimental measurement of the three-dimensional internal velocity field of a drop in a shear flow. Numerical simulations and theoretical models published in the past 30 years predict a toroidal internal recirculation flow, for which the entire surface flows streamwise. However, our measurements reveal a qualitatively different picture with a two-lobed recirculation, featuring two stagnation points at the surface and a reverse surface flow closer to the substrate. This finding appears to be independent of Reynolds number and viscosity ratio in the ranges studied; we conjecture that the observed flow is due to the effect of surfactants at the drop surface.

  10. Axisymmetric Granular Collapse: a Transient 3D flow Test of Viscoplasticity

    NASA Astrophysics Data System (ADS)

    Kerswell, Rich; Lacaze, Laurent

    2008-11-01

    The collapse of a stationary cylinder of granular material onto a horizontal plan is a deceptively simple experiment rich in flow behaviour. Using 3-dimensional soft particle simulations, we reproduce the observed scaling laws for the maximum final runout and height of the deposit as a function of the initial aspect ratio. The flow simulations of this unsteady, largely axisymmetric flow are then used to confront a recently-introduced visco-plastic continuum theory (Jop, Forterre & Pouliquen, Nature, 441,727,2006) which has seen some success modelling steady, unidirectional flows.

  11. Stability analysis for capillary channel flow: 1d and 3d computations

    NASA Astrophysics Data System (ADS)

    Grah, Aleksander; Klatte, Jörg; Dreyer, Michael E.

    The subject of the presentation are numerical studies on capillary channel flow, based on results of the sounding rocket TEXUS experiments. The flow through a capillary channel is established by a gear pump at the outlet. The channel, consists of two parallel glass plates with a width of 25 mm, a gap of 10 mm and a length of 12 mm. The meniscus of a compensation tube maintains a constant system pressure. Steady and dynamic pressure effects in the system force the surfaces to bend inwards. A maximum flow rate is achieved when the free surface collapses and gas ingestion occurs at the outlet. This critical flow rate depends on the channel geometry, the flow regime and the liquid properties. The aim of the experiments is the determination of the free surface shape and to find the maximum flow rate. In order to study the unsteady liquid loop behavior, a dimensionless one-dimensional model and a corresponding three-dimensional model were developed. The one-dimensional model is based on the unsteady Bernoulli equation, the unsteady continuity equation and geometrical conditions for the surface curvature and the flow cross-section. The experimental and evaluated contour data show good agreement for a sequence of transient flow rate perturbations. In the case of steady flow at maximum flow rate, when the "choking" effect occurs, the surfaces collapse and cause gas ingestion into the channel. This effect is related to the Speed Index. At the critical flow rate the Speed Index reaches the value 1, in analogy to the Mach Number. Unsteady choking does not necessarily cause surface collapse. We show, that temporarily Speed Index values exceeding One may be achieved for a perfectly stable supercritical dynamic flow. As a supercritical criterion for the dynamic free surface stability we define a Dynamic Index considering the local capillary pressure and the convective pressure, which is a function of the local velocity. The Dynamic Index is below One for stable flow while D = 1

  12. 3D FEM analyses on flow field characteristics of the valveless piezoelectric pump

    NASA Astrophysics Data System (ADS)

    Huang, Jun; Zhang, Jianhui; Shi, Weidong; Wang, Yuan

    2016-06-01

    Due to the special transportation and heat transfer characteristics, the fractal-like Y-shape branching tube is used in valveless piezoelectric pumps as a no-moving-part valve. However, there have been little analyses on the flow resistance of the valveless piezoelectric pump, which is critical to the performance of the valveless piezoelectric pump with fractal-like Y-shape branching tubes. Flow field of the piezoelectric pump is analyzed by the finite element method, and the pattern of the velocity streamlines is revealed, which can well explain the difference of total flow resistances of the piezoelectric pump. Besides, simplified numerical method is employed to calculate the export flow rate of piezoelectric pump, and the flow field of the piezoelectric pump is presented. The FEM computation shows that the maximum flow rate is 16.4 mL/min. Compared with experimental result, the difference between them is just 55.5%, which verifies the FEM method. The reasons of the difference between dividing and merging flow resistance of the valveless piezoelectric pump with fractal-like Y-shape branching tubes are also investigated in this method. The proposed research provides the instruction to design of novel piezoelectric pump and a rapid method to analyse the pump flow rate.

  13. 3D FEM analyses on flow field characteristics of the valveless piezoelectric pump

    NASA Astrophysics Data System (ADS)

    Huang, Jun; Zhang, Jianhui; Shi, Weidong; Wang, Yuan

    2016-07-01

    Due to the special transportation and heat transfer characteristics, the fractal-like Y-shape branching tube is used in valveless piezoelectric pumps as a no-moving-part valve. However, there have been little analyses on the flow resistance of the valveless piezoelectric pump, which is critical to the performance of the valveless piezoelectric pump with fractal-like Y-shape branching tubes. Flow field of the piezoelectric pump is analyzed by the finite element method, and the pattern of the velocity streamlines is revealed, which can well explain the difference of total flow resistances of the piezoelectric pump. Besides, simplified numerical method is employed to calculate the export flow rate of piezoelectric pump, and the flow field of the piezoelectric pump is presented. The FEM computation shows that the maximum flow rate is 16.4 mL/min. Compared with experimental result, the difference between them is just 55.5%, which verifies the FEM method. The reasons of the difference between dividing and merging flow resistance of the valveless piezoelectric pump with fractal-like Y-shape branching tubes are also investigated in this method. The proposed research provides the instruction to design of novel piezoelectric pump and a rapid method to analyse the pump flow rate.

  14. 3D Numerical Simulation of Turbulent Buoyant Flow and Heat Transport in a Curved Open Channel

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A three-dimensional buoyancy-extended version of kappa-epsilon turbulence model was developed for simulating the turbulent flow and heat transport in a curved open channel. The density- induced buoyant force was included in the model, and the influence of temperature stratification on flow field was...

  15. LDA measurement of the passage flow field in a 3-D airfoil cascade

    NASA Technical Reports Server (NTRS)

    Stauter, R. C.; Fleeter, S.

    1986-01-01

    Three-dimensional internal flow computational models are currently being developed to predict the flow through turbomachinery blade rows. For these codes to be of quantitative value, they must be verified with data obtained in experiments which model the fundamental flow phenomena. In this paper, the complete three-dimensional flow field through a subsonic annular cascade of cambered airfoils is experimentally quantified. In particular, detailed three-dimensional data are obtained to quantify the inlet velocity profile, the cascade passage velocity field, and the exit region flow field. The primary instrumentation for acquiring these data is a single-channel Laser Doppler Anemometer operating in the backscatter mode, with chordwise distributions of airfoil surface static pressure taps also utilized. Appropriate data are correlated with predictions from the MERIDL/TSONIC codes.

  16. Regional cerebral blood flow in schizophrenia

    SciTech Connect

    Mathew, R.J.; Duncan, G.C.; Weinman, M.L.; Barr, D.L.

    1982-10-01

    Regional cerebral blood flow (rCBF) was measured via xenon133 inhalation technique in 23 patients with schizophrenia and 18 age- and sex-matched controls. The mean blood flow to both hemispheres was found to be lower for the patients. The patients and their controls did not differ on interhemispheric differences in blood flow. There were no differences in rCBF between medicated and unmedicated, subchronic and chronic, and paranoid and nonparanoid patients. Hallucinations were associated with reduced blood flow to several postcentral regions.

  17. Linear and nonlinear instability and ligament dynamics in 3D laminar two-layer liquid/liquid flows

    NASA Astrophysics Data System (ADS)

    Ó Náraigh, Lennon; Valluri, Prashant; Scott, David; Bethune, Iain; Spelt, Peter

    2013-11-01

    We consider the linear and nonlinear stability of two-phase density-matched but viscosity contrasted fluids subject to laminar Poiseuille flow in a channel, paying particular attention to the formation of three-dimensional waves. The Orr-Sommerfeld-Squire analysis is used along with DNS of the 3D two-phase Navier-Stokes equations using our newly launched TPLS Solver (http://edin.ac/10cRKzS). For the parameter regimes considered, we demonstrate the existence of two distinct mechanisms whereby 3D waves enter the system, and dominate at late time. There exists a direct route, whereby 3D waves are amplified by the standard linear mechanism; for certain parameter classes, such waves grow at a rate less than but comparable to that of most-dangerous two-dimensional mode. Additionally, there is a weakly nonlinear route, whereby a purely spanwise wave couples to a streamwise mode and grows exponentially. We demonstrate these mechanisms in isolation and in concert. Consideration is also given to the ultimate state of these waves: persistent three-dimensional nonlinear waves are stretched and distorted by the base flow, thereby producing regimes of ligaments, ``sheets,'' or ``interfacial turbulence.'' HECToR RAP/dCSE Project e174, HPC-Europa 2.

  18. Texture-based visualization of unsteady 3D flow by real-time advection and volumetric illumination.

    PubMed

    Weiskopf, Daniel; Schafhitzel, Tobias; Ertl, Thomas

    2007-01-01

    This paper presents an interactive technique for the dense texture-based visualization of unsteady 3D flow, taking into account issues of computational efficiency and visual perception. High efficiency is achieved by a 3D graphics processing unit (GPU)-based texture advection mechanism that implements logical 3D grid structures by physical memory in the form of 2D textures. This approach results in fast read and write access to physical memory, independent of GPU architecture. Slice-based direct volume rendering is used for the final display. We investigate two alternative methods for the volumetric illumination of the result of texture advection: First, gradient-based illumination that employs a real-time computation of gradients, and, second, line-based lighting based on illumination in codimension 2. In addition to the Phong model, perception-guided rendering methods are considered, such as cool/warm shading, halo rendering, or color-based depth cueing. The problems of clutter and occlusion are addressed by supporting a volumetric importance function that enhances features of the flow and reduces visual complexity in less interesting regions. GPU implementation aspects, performance measurements, and a discussion of results are included to demonstrate our visualization approach.

  19. 3-D flow and scour near a submerged wing dike: ADCP measurements on the Missouri River

    USGS Publications Warehouse

    Jamieson, E.C.; Rennie, C.D.; Jacobson, R.B.; Townsend, R.D.

    2011-01-01

    Detailed mapping of bathymetry and three-dimensional water velocities using a boat-mounted single-beam sonar and acoustic Doppler current profiler (ADCP) was carried out in the vicinity of two submerged wing dikes located in the Lower Missouri River near Columbia, Missouri. During high spring flows the wing dikes become submerged, creating a unique combination of vertical flow separation and overtopping (plunging) flow conditions, causing large-scale three-dimensional turbulent flow structures to form. On three different days and for a range of discharges, sampling transects at 5 and 20 m spacing were completed, covering the area adjacent to and upstream and downstream from two different wing dikes. The objectives of this research are to evaluate whether an ADCP can identify and measure large-scale flow features such as recirculating flow and vortex shedding that develop in the vicinity of a submerged wing dike; and whether or not moving-boat (single-transect) data are sufficient for resolving complex three-dimensional flow fields. Results indicate that spatial averaging from multiple nearby single transects may be more representative of an inherently complex (temporally and spatially variable) three-dimensional flow field than repeated single transects. Results also indicate a correspondence between the location of calculated vortex cores (resolved from the interpolated three-dimensional flow field) and the nearby scour holes, providing new insight into the connections between vertically oriented coherent structures and local scour, with the unique perspective of flow and morphology in a large river. Copyright 2011 by the American Geophysical Union.

  20. The NCOREL computer program for 3D nonlinear supersonic potential flow computations

    NASA Technical Reports Server (NTRS)

    Siclari, M. J.

    1983-01-01

    An innovative computational technique (NCOREL) was established for the treatment of three dimensional supersonic flows. The method is nonlinear in that it solves the nonconservative finite difference analog of the full potential equation and can predict the formation of supercritical cross flow regions, embedded and bow shocks. The method implicitly computes a conical flow at the apex (R = 0) of a spherical coordinate system and uses a fully implicit marching technique to obtain three dimensional cross flow solutions. This implies that the radial Mach number must remain supersonic. The cross flow solutions are obtained by using type dependent transonic relaxation techniques with the type dependency linked to the character of the cross flow velocity (i.e., subsonic/supersonic). The spherical coordinate system and marching on spherical surfaces is ideally suited to the computation of wing flows at low supersonic Mach numbers due to the elimination of the subsonic axial Mach number problems that exist in other marching codes that utilize Cartesian transverse marching planes.

  1. Packing, alignment and flow of shape-anisotropic grains in a 3D silo experiment

    NASA Astrophysics Data System (ADS)

    Börzsönyi, Tamás; Somfai, Ellák; Szabó, Balázs; Wegner, Sandra; Mier, Pascal; Rose, Georg; Stannarius, Ralf

    2016-09-01

    Granular material flowing through bottlenecks, like the openings of silos, tend to clog and thus inhibit further flow. We study this phenomenon in a three-dimensional hopper for spherical and shape-anisotropic particles by means of x-ray tomography. The x-ray tomograms provide information on the bulk of the granular filling, and allows us to determine the particle positions and orientations inside the silo. In addition, it allows us to calculate local packing densities in different parts of the container. We find that in the flowing zone of the silo particles show a preferred orientation and thereby a higher order. Similarly to simple shear flows, the average orientation of the particles is not parallel to the streamlines but encloses a certain angle with it. In most parts of the hopper, the angular distribution of the particles did not reach the one corresponding to stationary shear flow, thus the average orientation angle in the hopper deviates more from the streamlines than in stationary shear flows. In the flowing parts of the silo, shear induced dilation is observed, which is more pronounced for elongated grains than for nearly spherical particles. The clogged state is characterized by a dome, i.e. the geometry of the layer of grains blocking the outflow. The shape of the dome depends on the particle shape.

  2. DCM3D: A dual-continuum, three-dimensional, ground-water flow code for unsaturated, fractured, porous media

    SciTech Connect

    Updegraff, C.D. ); Lee, C.E. ); Gallegos, D.P. )

    1991-02-01

    This report constitutes the user's manual for DCM3D. DCM3D is a computer code for solving three-dimensional, ground-water flow problems in variably saturated, fractured porous media. The code is based on a dual-continuum model with porous media comprising one continuum and fractures comprising the other. The continua are connected by a transfer term that depends on the unsaturated permeability of the porous medium. An integrated finite-difference scheme is used to discretize the governing equations in space. The time-dependent term is allowed to remain continuous. The resulting set of ordinary differential equations (ODE's) is solved with a general ODE solver, LSODES. The code is capable of handling transient, spatially dependent source terms and boundary conditions. The boundary conditions can either prescribed head or prescribed flux. 24 refs., 22 figs., 5 tabs.

  3. Bidirectional inward migration of particles lagging behind a Poiseuille flow in a rectangular microchannel for 3D particle focusing

    NASA Astrophysics Data System (ADS)

    Kim, Young Won; Yoo, Jung Yul

    2015-02-01

    Electrophoretic mobility of particles dispersed in an electrolyte solution induces the particles to lag behind a Poiseuille flow in a rectangular microchannel, which causes bidirectional inward migration of particles to the central axis of the channel. As a result, in the present theoretical and experimental study, three-dimensional (3D) particle focusing is clearly realized in such a manner that the particles are aligned in a single file along the axis of the channel as they are transported downstream. Theoretical prediction on the particle migration time provides an excellent assessment of the experimental results. The method proposed in the present study has potential for development of low-cost rapid manufacturing process of sheathless monolayer microchips for 3D particle focusing.

  4. Navier-Stokes simulation of 3-D hypersonic equilibrium air flow

    NASA Technical Reports Server (NTRS)

    Nagaraj, N.; Lombard, C. K.; Bardina, J.

    1988-01-01

    A computationally efficient three-dimensional conservative supracharacteristic Navier-Stokes method has been extended to simulate complex external chemically reacting flows of hypersonic reentry vehicles at angle-of-attack. Numerical simulation results of the flow around a sphere-cone-cone-flare reentry vehicle at 10 deg angle-of-attack are presented, in addition to the results of a well-validated two-dimensional code with which the 0-deg axisymmetric flow has been computed. A method for obtaining compositions of species in equilibrium ionized air is proposed.

  5. Effective Wall Friction in Wall-Bounded 3D Dense Granular Flows

    NASA Astrophysics Data System (ADS)

    Artoni, Riccardo; Richard, Patrick

    2015-10-01

    We report numerical simulations on granular shear flows confined between two flat but frictional sidewalls. Novel regimes differing by their strain localization features are observed. They originate from the competition between dissipation at the sidewalls and dissipation in the bulk of the flow. The effective friction at sidewalls is characterized (effective friction coefficient and orientation of the friction force) for each regime, and its interdependence with slip and force fluctuations is pointed out. We propose a simple scaling law linking the slip velocity to the granular temperature in the main flow direction which leads naturally to another scaling law for the effective friction.

  6. Simulation of 3-D viscous flow within a multi-stage turbine

    NASA Technical Reports Server (NTRS)

    Adamczyk, John J.; Celestina, Mark L.; Beach, Tim A.; Barnett, Mark

    1989-01-01

    This work outlines a procedure for simulating the flow field within multistage turbomachinery which includes the effects of unsteadiness, compressibility, and viscosity. The associated modeling equations are the average passage equation system which governs the time-averaged flow field within a typical passage of a blade row embedded within a multistage configuration. The results from a simulation of a low aspect ratio stage and a one-half turbine will be presented and compared with experimental measurements. It will be shown that the secondary flow field generated by the rotor causes the aerodynamic performance of the downstream vane to be significantly different from that of an isolated blade row.

  7. Computational studies of hard-body and 3-D effects in plume flows

    NASA Technical Reports Server (NTRS)

    Venkatapathy, Ethiraj; Feiereisen, William J.; Obayashi, Shigeru

    1989-01-01

    Axisymmetric and three-dimensional, multi-nozzle plume flows around generic rocket geometries are investigated with a three-dimensional Navier-Stokes solver to study the interactive effects between hard body and the plume. Time-asymptotic, laminar, ideal-gas solutions obtained with a two-factor, flux-split scheme and a diagonal, upwind scheme are presented. Computed solutions to three-dimensional, multi-nozzle problems and single-nozzle, axisymmetric problems demonstrate flow field features including three-dimensionality and hard-body effects. Geometry and three-dimensional effects are shown to be significant in multi-nozzle flows.

  8. PAB3D: Its History in the Use of Turbulence Models in the Simulation of Jet and Nozzle Flows

    NASA Technical Reports Server (NTRS)

    Abdol-Hamid, Khaled S.; Pao, S. Paul; Hunter, Craig A.; Deere, Karen A.; Massey, Steven J.; Elmiligui, Alaa

    2006-01-01

    This is a review paper for PAB3D s history in the implementation of turbulence models for simulating jet and nozzle flows. We describe different turbulence models used in the simulation of subsonic and supersonic jet and nozzle flows. The time-averaged simulations use modified linear or nonlinear two-equation models to account for supersonic flow as well as high temperature mixing. Two multiscale-type turbulence models are used for unsteady flow simulations. These models require modifications to the Reynolds Averaged Navier-Stokes (RANS) equations. The first scheme is a hybrid RANS/LES model utilizing the two-equation (k-epsilon) model with a RANS/LES transition function, dependent on grid spacing and the computed turbulence length scale. The second scheme is a modified version of the partially averaged Navier-Stokes (PANS) formulation. All of these models are implemented in the three-dimensional Navier-Stokes code PAB3D. This paper discusses computational methods, code implementation, computed results for a wide range of nozzle configurations at various operating conditions, and comparisons with available experimental data. Very good agreement is shown between the numerical solutions and available experimental data over a wide range of operating conditions.

  9. Fluid Flow Processes Study: from a 3D seismic data set in the Pointer Ridge offshore SW Taiwan

    NASA Astrophysics Data System (ADS)

    Han, Wei-Chung; Liu, Char-Shine; Chen, Liwen; Chi, Wu-Cheng; Lin, Che-Chuan

    2016-04-01

    This study analyzes a 3D seismic cube in the Pointer Ridge for understanding the fluid flow processes in subsurface. Pointer Ridge is a ridge situated on the passive China continental margin and is suggested as a potential prospect for future gas hydrate development. High methane flux rate, active gas venting and seismic chimneys have been observed in this area, which are direct evidences for active ongoing fluid migration processes. To find the possible fluid conduits and to understand how the fluids have migrated along those conduits, we firstly identify the structural and sedimentary features from this 3D seismic cube in our study area. Secondly, seismic attribute analyses are carried out for detecting fluid conduits and evaluating the contribution of recognized faults/fractures for fluid flow, respectively. Finally, we propose conceptual models to illustrate how fluids have migrated along those conduits to the seafloor and how those conduits have developed. The results show: 1) a major NE-SW striking normal fault (PR Fault) separates a depositional field on the hanging wall and a erosional field on the footwall; 2) the PR Fault zone itself and the chimneys in its footwall act as main conduits for focused fluid flow migrating to the seafloor; 3) the development of the chimneys in the Pointer Ridge area are highly controlled by the erosion and deposition processes. Since the ongoing fluid flow processes will increase the seafloor instabilities and the Pointer Ridge is a gas hydrate leaking site, our results could provide useful information for further risk evaluation.

  10. Holographic microscopy and microfluidics platform for measuring wall stress and 3D flow over surfaces textured by micro-pillars

    PubMed Central

    Bocanegra Evans, Humberto; Gorumlu, Serdar; Aksak, Burak; Castillo, Luciano; Sheng, Jian

    2016-01-01

    Understanding how fluid flow interacts with micro-textured surfaces is crucial for a broad range of key biological processes and engineering applications including particle dispersion, pathogenic infections, and drag manipulation by surface topology. We use high-speed digital holographic microscopy (DHM) in combination with a correlation based de-noising algorithm to overcome the optical interference generated by surface roughness and to capture a large number of 3D particle trajectories in a microfluidic channel with one surface patterned with micropillars. It allows us to obtain a 3D ensembled velocity field with an uncertainty of 0.06% and 2D wall shear stress distribution at the resolution of ~65 μPa. Contrary to laminar flow in most microfluidics, we find that the flow is three-dimensional and complex for the textured microchannel. While the micropillars affect the velocity flow field locally, their presence is felt globally in terms of wall shear stresses at the channel walls. These findings imply that micro-scale mixing and wall stress sensing/manipulation can be achieved through hydro-dynamically smooth but topologically rough micropillars. PMID:27353632

  11. Holographic microscopy and microfluidics platform for measuring wall stress and 3D flow over surfaces textured by micro-pillars

    NASA Astrophysics Data System (ADS)

    Bocanegra Evans, Humberto; Gorumlu, Serdar; Aksak, Burak; Castillo, Luciano; Sheng, Jian

    2016-06-01

    Understanding how fluid flow interacts with micro-textured surfaces is crucial for a broad range of key biological processes and engineering applications including particle dispersion, pathogenic infections, and drag manipulation by surface topology. We use high-speed digital holographic microscopy (DHM) in combination with a correlation based de-noising algorithm to overcome the optical interference generated by surface roughness and to capture a large number of 3D particle trajectories in a microfluidic channel with one surface patterned with micropillars. It allows us to obtain a 3D ensembled velocity field with an uncertainty of 0.06% and 2D wall shear stress distribution at the resolution of ~65 μPa. Contrary to laminar flow in most microfluidics, we find that the flow is three-dimensional and complex for the textured microchannel. While the micropillars affect the velocity flow field locally, their presence is felt globally in terms of wall shear stresses at the channel walls. These findings imply that micro-scale mixing and wall stress sensing/manipulation can be achieved through hydro-dynamically smooth but topologically rough micropillars.

  12. An innovative hybrid 3D analytic-numerical model for air breathing parallel channel counter-flow PEM fuel cells.

    PubMed

    Tavčar, Gregor; Katrašnik, Tomaž

    2014-01-01

    The parallel straight channel PEM fuel cell model presented in this paper extends the innovative hybrid 3D analytic-numerical (HAN) approach previously published by the authors with capabilities to address ternary diffusion systems and counter-flow configurations. The model's core principle is modelling species transport by obtaining a 2D analytic solution for species concentration distribution in the plane perpendicular to the cannel gas-flow and coupling consecutive 2D solutions by means of a 1D numerical pipe-flow model. Electrochemical and other nonlinear phenomena are coupled to the species transport by a routine that uses derivative approximation with prediction-iteration. The latter is also the core of the counter-flow computation algorithm. A HAN model of a laboratory test fuel cell is presented and evaluated against a professional 3D CFD simulation tool showing very good agreement between results of the presented model and those of the CFD simulation. Furthermore, high accuracy results are achieved at moderate computational times, which is owed to the semi-analytic nature and to the efficient computational coupling of electrochemical kinetics and species transport.

  13. Characterizing and Understanding Large-Scale Wave Propagation in the Atmosphere through Graphs of 3D Information Flow

    NASA Astrophysics Data System (ADS)

    Deng, Y.; Ebert-Uphoff, I.; Chen, J.

    2015-12-01

    Causal discovery seeks to discover potential cause-effect relationships from observational data. Here we adopt the idea of interpreting large-scale atmospheric dynamical processes, particularly those tied to propagation of large-scale waves, as information flow around the globe, which can then be calculated using causal discovery methods. We apply a well-established causal discovery algorithm - based on constraint-based structure learning of probabilistic graphical models - toward 51 years of 6-hourly, atmospheric isobaric-level geopotential height data to construct the first-ever graphs of 3D information flow in the atmosphere. These graphs are created globally for different seasons and their connection to phase/energy propagation of atmospheric waves are investigated. Specifically, we examine the information flows 1) in the topical region that represent horizontal and vertical propagations of Kelvin and Rossby-gravity waves whose associated momentum transfer are known to play a key role in the Quasi-Biennial Oscillation (QBO), and 2) in the northern extratropics that represent propagations of planetary-scale waves whose heat/momentum fluxes are responsible for vacillations in the polar stratospheric vortex and occurrences of extreme events such as the stratospheric sudden warming. The sensitivity of the constructed graphs of 3D information flow to data resolution and pre-processing methods (e.g., spatial and temporal filtering) will be discussed.

  14. An innovative hybrid 3D analytic-numerical model for air breathing parallel channel counter-flow PEM fuel cells.

    PubMed

    Tavčar, Gregor; Katrašnik, Tomaž

    2014-01-01

    The parallel straight channel PEM fuel cell model presented in this paper extends the innovative hybrid 3D analytic-numerical (HAN) approach previously published by the authors with capabilities to address ternary diffusion systems and counter-flow configurations. The model's core principle is modelling species transport by obtaining a 2D analytic solution for species concentration distribution in the plane perpendicular to the cannel gas-flow and coupling consecutive 2D solutions by means of a 1D numerical pipe-flow model. Electrochemical and other nonlinear phenomena are coupled to the species transport by a routine that uses derivative approximation with prediction-iteration. The latter is also the core of the counter-flow computation algorithm. A HAN model of a laboratory test fuel cell is presented and evaluated against a professional 3D CFD simulation tool showing very good agreement between results of the presented model and those of the CFD simulation. Furthermore, high accuracy results are achieved at moderate computational times, which is owed to the semi-analytic nature and to the efficient computational coupling of electrochemical kinetics and species transport. PMID:25125112

  15. Calculations of separated 3-D flows with a pressure-staggered Navier-Stokes equations solver

    NASA Technical Reports Server (NTRS)

    Kim, S.-W.

    1991-01-01

    A Navier-Stokes equations solver based on a pressure correction method with a pressure-staggered mesh and calculations of separated three-dimensional flows are presented. It is shown that the velocity pressure decoupling, which occurs when various pressure correction algorithms are used for pressure-staggered meshes, is caused by the ill-conditioned discrete pressure correction equation. The use of a partial differential equation for the incremental pressure eliminates the velocity pressure decoupling mechanism by itself and yields accurate numerical results. Example flows considered are a three-dimensional lid driven cavity flow and a laminar flow through a 90 degree bend square duct. For the lid driven cavity flow, the present numerical results compare more favorably with the measured data than those obtained using a formally third order accurate quadratic upwind interpolation scheme. For the curved duct flow, the present numerical method yields a grid independent solution with a very small number of grid points. The calculated velocity profiles are in good agreement with the measured data.

  16. Increased hippocampal blood volume and normal blood flow in schizophrenia

    PubMed Central

    Talati, Pratik; Rane, Swati; Skinner, Jack; Gore, John; Heckers, Stephan

    2015-01-01

    Neuroimaging studies have provided compelling evidence for abnormal hippocampal activity in schizophrenia. Most studies made inferences about baseline hippocampal activity using a single hemodynamic parameter (e.g., blood volume or blood flow). Here we studied several hemodynamic measures in the same cohort to test the hypothesis of increased hippocampal activity in schizophrenia. We used dynamic susceptibility contrast- (DSC-) magnetic resonance imaging to assess blood volume, blood flow, and mean transit time in the hippocampus of 15 patients with chronic schizophrenia and 15 healthy controls. Left and right hippocampal measurements were combined for absolute measures of cerebral blood volume (CBV), blood flow (CBF), and mean transit time (MTT). We found significantly increased hippocampal CBV, but normal CBF and MTT, in schizophrenia. The uncoupling of CBV and CBF could be due to several factors, including antipsychotic medication, loss of cerebral perfusion pressure, or angiogenesis. Further studies need to incorporate several complementary imaging modalities to better characterize hippocampal dysfunction in schizophrenia. PMID:25896442

  17. Fibroblast alignment under interstitial fluid flow using a novel 3-D tissue culture model.

    PubMed

    Ng, Chee Ping; Swartz, Melody A

    2003-05-01

    Interstitial flow is an important component of the microcirculation and interstitial environment, yet its effects on cell organization and tissue architecture are poorly understood, in part due to the lack of in vitro models. To examine the effects of interstitial flow on cell morphology and matrix remodeling, we developed a tissue culture model that physically supports soft tissue cultures and allows microscopic visualization of cells within the three-dimensional matrix. In addition, pressure-flow relationships can be continuously monitored to evaluate the bulk hydraulic resistance as an indicator of changes in the overall matrix integrity. We observed that cells such as human dermal fibroblasts aligned perpendicular to the direction of interstitial flow. In contrast, fibroblasts in static three-dimensional controls remained randomly oriented, whereas cells subjected to fluid shear as a two-dimensional monolayer regressed. Also, the dynamic measurements of hydraulic conductivity suggest reorganization toward a steady state. These primary findings help establish the importance of interstitial flow on the biology of tissue organization and interstitial fluid balance. PMID:12531726

  18. A parallel overset-curvilinear-immersed boundary framework for simulating complex 3D incompressible flows.

    PubMed

    Borazjani, Iman; Ge, Liang; Le, Trung; Sotiropoulos, Fotis

    2013-04-01

    We develop an overset-curvilinear immersed boundary (overset-CURVIB) method in a general non-inertial frame of reference to simulate a wide range of challenging biological flow problems. The method incorporates overset-curvilinear grids to efficiently handle multi-connected geometries and increase the resolution locally near immersed boundaries. Complex bodies undergoing arbitrarily large deformations may be embedded within the overset-curvilinear background grid and treated as sharp interfaces using the curvilinear immersed boundary (CURVIB) method (Ge and Sotiropoulos, Journal of Computational Physics, 2007). The incompressible flow equations are formulated in a general non-inertial frame of reference to enhance the overall versatility and efficiency of the numerical approach. Efficient search algorithms to identify areas requiring blanking, donor cells, and interpolation coefficients for constructing the boundary conditions at grid interfaces of the overset grid are developed and implemented using efficient parallel computing communication strategies to transfer information among sub-domains. The governing equations are discretized using a second-order accurate finite-volume approach and integrated in time via an efficient fractional-step method. Various strategies for ensuring globally conservative interpolation at grid interfaces suitable for incompressible flow fractional step methods are implemented and evaluated. The method is verified and validated against experimental data, and its capabilities are demonstrated by simulating the flow past multiple aquatic swimmers and the systolic flow in an anatomic left ventricle with a mechanical heart valve implanted in the aortic position.

  19. A parallel overset-curvilinear-immersed boundary framework for simulating complex 3D incompressible flows

    PubMed Central

    Borazjani, Iman; Ge, Liang; Le, Trung; Sotiropoulos, Fotis

    2013-01-01

    We develop an overset-curvilinear immersed boundary (overset-CURVIB) method in a general non-inertial frame of reference to simulate a wide range of challenging biological flow problems. The method incorporates overset-curvilinear grids to efficiently handle multi-connected geometries and increase the resolution locally near immersed boundaries. Complex bodies undergoing arbitrarily large deformations may be embedded within the overset-curvilinear background grid and treated as sharp interfaces using the curvilinear immersed boundary (CURVIB) method (Ge and Sotiropoulos, Journal of Computational Physics, 2007). The incompressible flow equations are formulated in a general non-inertial frame of reference to enhance the overall versatility and efficiency of the numerical approach. Efficient search algorithms to identify areas requiring blanking, donor cells, and interpolation coefficients for constructing the boundary conditions at grid interfaces of the overset grid are developed and implemented using efficient parallel computing communication strategies to transfer information among sub-domains. The governing equations are discretized using a second-order accurate finite-volume approach and integrated in time via an efficient fractional-step method. Various strategies for ensuring globally conservative interpolation at grid interfaces suitable for incompressible flow fractional step methods are implemented and evaluated. The method is verified and validated against experimental data, and its capabilities are demonstrated by simulating the flow past multiple aquatic swimmers and the systolic flow in an anatomic left ventricle with a mechanical heart valve implanted in the aortic position. PMID:23833331

  20. Optical coherence Doppler tomography for quantitative cerebral blood flow imaging

    PubMed Central

    You, Jiang; Du, Congwu; Volkow, Nora D.; Pan, Yingtian

    2014-01-01

    Optical coherence Doppler tomography (ODT) is a promising neurotechnique that permits 3D imaging of the cerebral blood flow (CBF) network; however, quantitative CBF velocity (CBFv) imaging remains challenging. Here we present a simple phase summation method to enhance slow capillary flow detection sensitivity without sacrificing dynamic range for fast flow and vessel tracking to improve angle correction for absolute CBFv quantification. Flow phantom validation indicated that the CBFv quantification accuracy increased from 15% to 91% and the coefficient of variation (CV) decreased 9.3-fold; in vivo mouse brain validation showed that CV decreased 4.4-/10.8- fold for venular/arteriolar flows. ODT was able to identify cocaine-elicited microischemia and quantify CBFv disruption in branch vessels and capillaries that otherwise would have not been possible. PMID:25401033

  1. Two phase liquid helium flow testing to simulate the operation of a cryocondensation pump in the D3-D tokamak

    NASA Astrophysics Data System (ADS)

    Laughon, G. J.; Baxi, C. B.; Campbell, G. L.; Mahdavi, M. A.; Makariou, C. C.; Smith, J. P.; Schaffer, M. J.; Schaubel, K. M.; Menon, M. M.

    1994-06-01

    A liquid helium-cooled cryocondensation pump has been installed in the D3-D tokamak fusion energy research experiment at General Atomics. The pump is located within the tokamak vacuum chamber beneath the divertor baffle plates and is utilized for plasma density and contamination control. Two-phase helium flows through the pump at 5 to 10 g/s utilizing the heat transfer and constant temperature characteristics of boiling liquid . helium. The pump is designed for a pumping speed of 32,000 1/s. Extensive testing was performed with a prototypical pump test fixture. Several pump geometries (simple tube, coaxial flow plug, and coaxial slotted insert) were tested, in an iterative process, to determine which was the most satisfactory for stable cryocondensation pumping. Results from the different tests illustrating the temperature distribution and flow characteristics for each configuration are presented.

  2. Assessment of an Unstructured-Grid Method for Predicting 3-D Turbulent Viscous Flows

    NASA Technical Reports Server (NTRS)

    Frink, Neal T.

    1996-01-01

    A method Is presented for solving turbulent flow problems on three-dimensional unstructured grids. Spatial discretization Is accomplished by a cell-centered finite-volume formulation using an accurate lin- ear reconstruction scheme and upwind flux differencing. Time is advanced by an implicit backward- Euler time-stepping scheme. Flow turbulence effects are modeled by the Spalart-Allmaras one-equation model, which is coupled with a wall function to reduce the number of cells in the sublayer region of the boundary layer. A systematic assessment of the method is presented to devise guidelines for more strategic application of the technology to complex problems. The assessment includes the accuracy In predictions of skin-friction coefficient, law-of-the-wall behavior, and surface pressure for a flat-plate turbulent boundary layer, and for the ONERA M6 wing under a high Reynolds number, transonic, separated flow condition.

  3. An improved version of NCOREL: A computer program for 3-D nonlinear supersonic potential flow computations

    NASA Technical Reports Server (NTRS)

    Siclari, Michael J.

    1988-01-01

    A computer code called NCOREL (for Nonconical Relaxation) has been developed to solve for supersonic full potential flows over complex geometries. The method first solves for the conical at the apex and then marches downstream in a spherical coordinate system. Implicit relaxation techniques are used to numerically solve the full potential equation at each subsequent crossflow plane. Many improvements have been made to the original code including more reliable numerics for computing wing-body flows with multiple embedded shocks, inlet flow through simulation, wake model and entropy corrections. Line relaxation or approximate factorization schemes are optionally available. Improved internal grid generation using analytic conformal mappings, supported by a simple geometric Harris wave drag input that was originally developed for panel methods and internal geometry package are some of the new features.

  4. Finite element methods of analysis for 3D inviscid compressible flows

    NASA Technical Reports Server (NTRS)

    Peraire, Jaime

    1990-01-01

    The applicants have developed a finite element based approach for the solution of three-dimensional compressible flows. The procedure enables flow solutions to be obtained on tetrahedral discretizations of computational domains of complex form. A further development was the incorporation of a solution adaptive mesh strategy in which the adaptivity is achieved by complete remeshing of the solution domain. During the previous year, the applicants were working with the Advanced Aerodynamics Concepts Branch at NASA Ames Research Center with an implementation of the basic meshing and solution procedure. The objective of the work to be performed over this twelve month period was the transfer of the adaptive mesh technology and also the undertaking of basic research into alternative flow algorithms for the Euler equations on unstructured meshes.

  5. Assessment of an Unstructured-Grid Method for Predicting 3-D Turbulent Viscous Flows

    NASA Technical Reports Server (NTRS)

    Frink, Neal T.

    1996-01-01

    A method is presented for solving turbulent flow problems on three-dimensional unstructured grids. Spatial discretization is accomplished by a cell-centered finite-volume formulation using an accurate linear reconstruction scheme and upwind flux differencing. Time is advanced by an implicit backward-Euler time-stepping scheme. Flow turbulence effects are modeled by the Spalart-Allmaras one-equation model, which is coupled with a wall function to reduce the number of cells in the sublayer region of the boundary layer. A systematic assessment of the method is presented to devise guidelines for more strategic application of the technology to complex problems. The assessment includes the accuracy in predictions of skin-friction coefficient, law-of-the-wall behavior, and surface pressure for a flat-plate turbulent boundary layer, and for the ONERA M6 wing under a high Reynolds number, transonic, separated flow condition.

  6. Multifractality of cerebral blood flow

    NASA Astrophysics Data System (ADS)

    West, Bruce J.; Latka, Miroslaw; Glaubic-Latka, Marta; Latka, Dariusz

    2003-02-01

    Scale invariance, the property relating time series across multiple scales, has provided a new perspective of physiological phenomena and their underlying control systems. The traditional “signal plus noise” paradigm of the engineer was first replaced with a model in which biological time series have a fractal structure in time (Fractal Physiology, Oxford University Press, Oxford, 1994). This new paradigm was subsequently shown to be overly restrictive when certain physiological signals were found to be characterized by more than one scaling parameter and therefore to belong to a class of more complex processes known as multifractals (Fractals, Plenum Press, New York, 1988). Here we demonstrate that in addition to heart rate (Nature 399 (1999) 461) and human gait (Phys. Rev. E, submitted for publication), the nonlinear control system for cerebral blood flow (CBF) (Phys. Rev. Lett., submitted for publication; Phys. Rev. E 59 (1999) 3492) is multifractal. We also find that this multifractality is greatly reduced for subjects with “serious” migraine and we present a simple model for the underlying control process to describe this effect.

  7. Numerical study on the 3-D complex characteristics of flow around the hull structure of TLP

    NASA Astrophysics Data System (ADS)

    Gu, Jia-yang; Zhu, Xin-yao; Yang, Jian-min; Lu, Yan-xiang; Xiao, Long-fei

    2015-06-01

    Vortex-induced motion is based on the complex characteristics of the flow around the tension leg platform (TLP) hull. By considering the flow field of the South China Sea and the configuration of the platform, three typical flow velocities and three flow directions are chosen to study the numerical simulation of the flow field characteristics around the TLP hull. Reynolds-averaged Navier-Stokes equations combined with the detached eddy simulation turbulence model are employed in the numerical study. The hydrodynamic coefficients of columns and pontoons, the total drag and lift coefficients of the TLP, the formation and development of the wake, and the vorticity iso-surfaces for different inlet velocities and current directions are discussed in this paper. The average value of the drag coefficient of the upstream columns is considerably larger than that of the downstream columns in the inlet direction of 0°. Although the time history of the lift coefficient demonstrates a "beating" behavior, the plot shows regularity in general. The Strouhal number decreases as the inlet velocity increases from the power spectral density plot at different flow velocities. The mean root values of the lift and drag coefficients of the front column decrease as the current direction increases. Under the symmetrical configuration of 45°, the streamwise force on C4 is the smallest, whereas the transverse force is the largest. The broken vortex conditions in current directions of 22.5° and 45° are more serious than that in the current direction of 0°. In addition, turbulence at the bottom of the TLP becomes stronger when the current direction changes from 0° to 45°. However, a high inlet velocity indicates a large region influenced by the broken vortex and shows the emergence of the wake behind the TLP under the same current angle.

  8. Numerical solution of 2D and 3D turbulent internal flow problems

    NASA Astrophysics Data System (ADS)

    Chen, Naixing; Xu, Yanji

    1991-08-01

    The paper describes a method for solving numerically two-dimensional or axisymmetric, and three-dimensional turbulent internal flow problems. The method is based on an implicit upwinding relaxation scheme with an arbitrarily shaped conservative control volume. The compressible Reynolds-averaged Navier-Stokes equations are solved with a two-equation turbulence model. All these equations are expressed by using a nonorthogonal curvilinear coordinate system. The method is applied to study the compressible internal flow in modern power installations. It has been observed that predictions for two-dimensional and three-dimensional channels show very good agreement with experimental results.

  9. Measurement of near-wall 3D flow velocity from wave-guiding micro-pillars.

    PubMed

    Bruecker, Christoph

    2016-09-19

    The measurement of near-wall flow in a plane close to the wall is achieved using the wave-guiding feature of transparent flexible micro-pillars which are attached in a 2D array to a surface and bend with the flow. Optical detection of bending from below the surface and application of auto-correlation methods provide mean and fluctuating part of the components of the wall-parallel velocity components. In addition, the wall-normal fluid motion is determined from spatial gradients in the array. The data provide the three-component velocity vector field in a plane close to the wall as well as their statistics.

  10. Application of digital interferogram evaluation techniques to the measurement of 3-D flow fields

    NASA Technical Reports Server (NTRS)

    Becker, Friedhelm; Yu, Yung H.

    1987-01-01

    A system for digitally evaluating interferograms, based on an image processing system connected to a host computer, was implemented. The system supports one- and two-dimensional interferogram evaluations. Interferograms are digitized, enhanced, and then segmented. The fringe coordinates are extracted, and the fringes are represented as polygonal data structures. Fringe numbering and fringe interpolation modules are implemented. The system supports editing and interactive features, as well as graphic visualization. An application of the system to the evaluation of double exposure interferograms from the transonic flow field around a helicopter blade and the reconstruction of the three dimensional flow field is given.

  11. Correlation-based discrimination between cardiac tissue and blood for segmentation of the left ventricle in 3-D echocardiographic images.

    PubMed

    Saris, Anne E C M; Nillesen, Maartje M; Lopata, Richard G P; de Korte, Chris L

    2014-03-01

    For automated segmentation of 3-D echocardiographic images, incorporation of temporal information may be helpful. In this study, optimal settings for calculation of temporal cross-correlations between subsequent time frames were determined, to obtain the maximum cross-correlation (MCC) values that provided the best contrast between blood and cardiac tissue over the entire cardiac cycle. Both contrast and boundary gradient quality measures were assessed to optimize MCC values with respect to signal choice (radiofrequency or envelope data) and axial window size. Optimal MCC values were incorporated into a deformable model to automatically segment the left ventricular cavity. MCC values were tested against, and combined with, filtered, demodulated radiofrequency data. Results reveal that using envelope data in combination with a relatively small axial window (0.7-1.25 mm) at fine scale results in optimal contrast and boundary gradient between the two tissues over the entire cardiac cycle. Preliminary segmentation results indicate that incorporation of MCC values has additional value for automated segmentation of the left ventricle. PMID:24412178

  12. Modeling Three-Phase Compositional Flow on Complex 3D Unstructured Grids with Higher-Order Finite Element Methods

    NASA Astrophysics Data System (ADS)

    Moortgat, J.; Firoozabadi, A.

    2013-12-01

    Most problems of interest in hydrogeology and subsurface energy resources involve complex heterogeneous geological formations. Such domains are most naturally represented in numerical reservoir simulations by unstructured computational grids. Finite element methods are a natural choice to describe fluid flow on unstructured meshes, because the governing equations can be readily discretized for any grid-element geometry. In this work, we consider the challenging problem of fully compositional three-phase flow in 3D unstructured grids, discretized by tetrahedra, prisms, or hexahedra, and compare to simulations on 3D structured grids. We employ a combination of mixed hybrid finite element methods to solve for the pressure and flux fields in a fractional flow formulation, and higher-order discontinuous Galerkin methods for the mass transport equations. These methods are well suited to simulate flow in heterogeneous and fractured reservoirs, because they provide a globally continuous pressure and flux field, while allowing for sharp discontinuities in the phase properties, such as compositions and saturations. The increased accuracy from using higher-order methods improves the modeling of highly non-linear flow, such as gravitational and viscous fingering. We present several numerical examples to study convergence rates and the (lack of) sensitivity to gridding/mesh orientation, and mesh quality. These examples consider gravity depletion, water and gas injection in oil saturated subsurface reservoirs with species exchange between up to three fluid phases. The examples demonstrate the wide applicability of our chosen finite element methods in the study of challenging multiphase flow problems in porous, geometrically complex, subsurface media.

  13. Digital-Particle-Image-Velocimetry (DPIV) in a scanning light-sheet: 3D starting flow around a short cylinder

    NASA Astrophysics Data System (ADS)

    Brücker, Ch.

    1995-08-01

    Scanning-Particle-Image-Velocimetry Technique (SPIV), introduced by Brücker (1992) and Brücker and Althaus (1992), offers the quantitative investigation of three-dimensional vortical structures in unsteady flows. On principle, this technique combines classical Particle-Image-Velocimetry (PIV) with volume scanning using a scanning light-sheet. In our previous studies, single scans obtained from photographic frame series were evaluated to show the instantaneous vortical structure of the respective flow phenomena. Here, continuous video recordings are processed to capture also the temporal information for the study of the set-up of 3D effects in the cylinder wake. The flow is continuously sampled in depth by the scanning light-sheet and in each of the parallel planes frame-to-frame cross-correlation of the video images (DPIV) is applied to obtain the 2D velocity field. Because the scanning frequency and repetition rate is high in comparison with the characteristic time-scale of the flow, the evaluation provides a complete time-record of the 3D flow during the starting process. With use of the continuity concept as described by Robinson and Rockwell (1993), we obtained in addition the out-of-plane component of the velocity in spanwise direction. This in view, the described technique enabled the reconstruction of the three-dimensional time-dependent velocity and vorticity field. The visualization of the dynamical behaviour of these quantities as, e.g. by video, gave a good impression of the spanwise flow showing the “tornado-like” suction effect of the starting vortices.

  14. Predictive Modeling of the Evolution of Fault Structure: 3-D Modeling and Coupled Geomechanical/Flow Simulation

    NASA Astrophysics Data System (ADS)

    Thornton, D. A.; Crook, A. J. L.

    2014-09-01

    Reconstruction of geological structures has the potential to provide additional insight into the effect of the depositional history on the current-day geomechanical and hydro-geologic state. Accurate modeling of the reconstruction process is, however, complex, necessitating advanced procedures for the prediction of fault formation and evolution within fully coupled geomechanical, fluid flow and temperature fields. In this paper, a 3-D computational approach is presented that is able to forward model complex structural evolution with multiple intersecting faults that exhibit large relative movement within a coupled geomechanical/flow environment. The approach adopts the Lagrangian method, complemented by robust and efficient automated adaptive meshing techniques, an elasto-plastic constitutive model based on critical state concepts, and global energy dissipation regularized by inclusion of fracture energy in the equations governing state variable evolution. The proposed model is validated by comparison of 2-D plane strain and 3-D thin-slice predictions of a bench-scale experiment, and then applied to two conceptual coupled geomechanical/fluid flow field-scale benchmarks.

  15. Vascular structure determines pulmonary blood flow distribution.

    PubMed

    Hlastala, M P; Glenny, R W

    1999-10-01

    Scientific knowledge develops through the evolution of new concepts. This process is usually driven by new methodologies that provide observations not previously available. Understanding of pulmonary blood flow determinants advanced significantly in the 1960s and is now changing rapidly again, because of increased spatial resolution of regional pulmonary blood flow measurements.

  16. Wall shear stress characterization of a 3D bluff-body separated flow

    NASA Astrophysics Data System (ADS)

    Fourrié, Grégoire; Keirsbulck, Laurent; Labraga, Larbi

    2013-10-01

    Efficient flow control strategies aimed at reducing the aerodynamic drag of road vehicles require a detailed knowledge of the reference flow. In this work, the flow around the rear slanted window of a generic car model was experimentally studied through wall shear stress measurements using an electrochemical method. The mean and fluctuating wall shear stress within the wall impact regions of the recirculation bubble and the main longitudinal vortex structures which develop above the rear window are presented. Correlations allow a more detailed characterization of the recirculation phenomenon within the separation bubble. In the model symmetry plane the recirculation structure compares well with simpler 2D configurations; specific lengths, flapping motion and shedding of large-scale vortices are observed, these similarities diminish when leaving the middle plane due to the strong three-dimensionality of the flow. A specific attention is paid to the convection processes occurring within the recirculation: a downstream convection velocity is observed, in accordance with 2D recirculations from the literature, and an upstream convection is highlighted along the entire bubble length which has not been underlined in some previous canonical configurations.

  17. Lift force time delays on 2D and 3D wings in unsteady flows

    NASA Astrophysics Data System (ADS)

    Williams, David; Colling, Jesse; Quach, Vien; Colonius, Tim; Tadmor, Gilead

    2008-11-01

    Active flow control (AFC) used for enhancing the maneuverability of wings is usually applied during conditions of steady external flow. However, when the external flow is unsteady or the wing is maneuvering, then at least two time delays become important; namely, the time delay of the lift to changes in external flow, τf, and the time delay to changes in AFC actuation, τa. These time delays were measured in wind tunnel experiments using two- and three-dimensional wings in an oscillating freestream and with variable duty cycle actuation. Dimensionless freestream oscillation frequencies from k = 0.01 to k = 0.2 with amplitudes of 5 percent of the mean speed were used to characterize the system. As a demonstration of the important role of the two time constants, AFC is used to damp lift force oscillations occurring in an unsteady freestream using a feed forward control system. The instantaneous velocity provides input to a control algorithm which adjusts the duty cycle of the AFC actuator to suppress lift fluctuations.

  18. Investigation on 3D t wake flow structures of swimming bionic fish

    NASA Astrophysics Data System (ADS)

    Shen, G.-X.; Tan, G.-K.; Lai, G.-J.

    2012-10-01

    A bionic experimental platform was designed for the purpose of investigating time accurate three-dimensional flow field, using digital particle image velocimetry (DSPIV). The wake behind the flapping trail of a robotic fish model was studied at high spatial resolution. The study was performed in a water channel. A robot fish model was designed and built. The model was fixed onto a rigid support framework using a cable-supporting method, with twelve stretched wires. The entire tail of the model can perform prescribed motions in two degrees of freedom, mainly in carangiform mode, by driving its afterbody and lunate caudal fin respectively. The DSPIV system was set up to operate in a translational manner, measuring velocity field in a series of parallel slices. Phase locked measurements were repeated for a number of runs, allowing reconstruction of phase average flow field. Vortex structures with phase history of the wake were obtained. The study reveals some new and complex three-dimensional flow structures in the wake of the fish, including "reverse hairpin vortex" and "reverse Karman S-H vortex rings", allowing insight into physics of this complex flow.

  19. Computer Tomography 3-D Imaging of the Metal Deformation Flow Path in Friction Stir Welding

    NASA Technical Reports Server (NTRS)

    Schneider, Judy; Beshears, Ronald; Nunes, Arthur C., Jr.

    2004-01-01

    In friction stir welding, a rotating threaded pin tool is inserted into a weld seam and literally stirs the edges of the seam together. This solid-state technique has been successfully used in the joining of materials that are difficult to fusion weld such as aluminum alloys. To determine optimal processing parameters for producing a defect free weld, a better understanding of the resulting metal deformation flow path is required. Marker studies are the principal method of studying the metal deformation flow path around the FSW pin tool. In our study, we have used computed tomography (CT) scans to reveal the flow pattern of a lead wire embedded in a FSW weld seam. At the welding temperature of aluminum, the lead becomes molten and thus tracks the aluminum deformation flow paths in a unique 3-dimensional manner. CT scanning is a convenient and comprehensive way of collecting and displaying tracer data. It marks an advance over previous more tedious and ambiguous radiographic/metallographic data collection methods.

  20. Dual FIB-SEM 3D imaging and lattice boltzmann modeling of porosimetry and multiphase flow in chalk.

    SciTech Connect

    Rinehart, Alex; Petrusak, Robin; Heath, Jason E.; Dewers, Thomas A.; Yoon, Hongkyu

    2010-12-01

    Mercury intrusion porosimetry (MIP) is an often-applied technique for determining pore throat distributions and seal analysis of fine-grained rocks. Due to closure effects, potential pore collapse, and complex pore network topologies, MIP data interpretation can be ambiguous, and often biased toward smaller pores in the distribution. We apply 3D imaging techniques and lattice-Boltzmann modeling in interpreting MIP data for samples of the Cretaceous Selma Group Chalk. In the Mississippi Interior Salt Basin, the Selma Chalk is the apparent seal for oil and gas fields in the underlying Eutaw Fm., and, where unfractured, the Selma Chalk is one of the regional-scale seals identified by the Southeast Regional Carbon Sequestration Partnership for CO2 injection sites. Dual focused ion - scanning electron beam and laser scanning confocal microscopy methods are used for 3D imaging of nanometer-to-micron scale microcrack and pore distributions in the Selma Chalk. A combination of image analysis software is used to obtain geometric pore body and throat distributions and other topological properties, which are compared to MIP results. 3D data sets of pore-microfracture networks are used in Lattice Boltzmann simulations of drainage (wetting fluid displaced by non-wetting fluid via the Shan-Chen algorithm), which in turn are used to model MIP procedures. Results are used in interpreting MIP results, understanding microfracture-matrix interaction during multiphase flow, and seal analysis for underground CO2 storage.

  1. Validation of a Node-Centered Wall Function Model for the Unstructured Flow Code FUN3D

    NASA Technical Reports Server (NTRS)

    Carlson, Jan-Renee; Vasta, Veer N.; White, Jeffery

    2015-01-01

    In this paper, the implementation of two wall function models in the Reynolds averaged Navier-Stokes (RANS) computational uid dynamics (CFD) code FUN3D is described. FUN3D is a node centered method for solving the three-dimensional Navier-Stokes equations on unstructured computational grids. The first wall function model, based on the work of Knopp et al., is used in conjunction with the one-equation turbulence model of Spalart-Allmaras. The second wall function model, also based on the work of Knopp, is used in conjunction with the two-equation k-! turbulence model of Menter. The wall function models compute the wall momentum and energy flux, which are used to weakly enforce the wall velocity and pressure flux boundary conditions in the mean flow momentum and energy equations. These wall conditions are implemented in an implicit form where the contribution of the wall function model to the Jacobian are also included. The boundary conditions of the turbulence transport equations are enforced explicitly (strongly) on all solid boundaries. The use of the wall function models is demonstrated on four test cases: a at plate boundary layer, a subsonic di user, a 2D airfoil, and a 3D semi-span wing. Where possible, different near-wall viscous spacing tactics are examined. Iterative residual convergence was obtained in most cases. Solution results are compared with theoretical and experimental data for several variations of grid spacing. In general, very good comparisons with data were achieved.

  2. Size based sorting and patterning of microbeads by evaporation driven flow in a 3D micro-traps array.

    PubMed

    Wong, Chee Chung; Liu, Yuxin; Wang, Karen Yanping; Rahman, Abdur Rub Abdur

    2013-09-21

    We present a three-dimensional (3D) micro-traps array for size selective sorting and patterning of microbeads via evaporation-driven capillary flow. The interconnected micro-traps array was manufactured by silicon micromachining. Microliters of aqueous solution containing particle mixtures of different sized (0.2 to 20 μm diameter) beads were dispensed onto the micro-traps substrate. The smaller particles spontaneously wicked towards the periphery of the chip, while the larger beads were orderly docked within the micro-traps array.

  3. Pancreatic islet blood flow and its measurement

    PubMed Central

    Jansson, Leif; Barbu, Andreea; Bodin, Birgitta; Drott, Carl Johan; Espes, Daniel; Gao, Xiang; Grapensparr, Liza; Källskog, Örjan; Lau, Joey; Liljebäck, Hanna; Palm, Fredrik; Quach, My; Sandberg, Monica; Strömberg, Victoria; Ullsten, Sara; Carlsson, Per-Ola

    2016-01-01

    Pancreatic islets are richly vascularized, and islet blood vessels are uniquely adapted to maintain and support the internal milieu of the islets favoring normal endocrine function. Islet blood flow is normally very high compared with that to the exocrine pancreas and is autonomously regulated through complex interactions between the nervous system, metabolites from insulin secreting β-cells, endothelium-derived mediators, and hormones. The islet blood flow is normally coupled to the needs for insulin release and is usually disturbed during glucose intolerance and overt diabetes. The present review provides a brief background on islet vascular function and especially focuses on available techniques to measure islet blood perfusion. The gold standard for islet blood flow measurements in experimental animals is the microsphere technique, and its advantages and disadvantages will be discussed. In humans there are still no methods to measure islet blood flow selectively, but new developments in radiological techniques hold great hopes for the future. PMID:27124642

  4. Subcutaneous blood flow in psoriasis

    SciTech Connect

    Klemp, P.

    1985-03-01

    The simultaneously recorded disappearance rates of /sup 133/xe from subcutaneous adipose tissue in the crus were studied in 10 patients with psoriasis vulgaris using atraumatic labeling of the tissue in lesional skin (LS) areas and symmetrical, nonlesional skin (NLS) areas. Control experiments were performed bilaterally in 10 younger, healthy subjects. The subcutaneous washout rate constant was significantly higher in LS, 0.79 +/- 0.05 min-1 x 10(2) compared to the washout rate constant of NLS, 0.56 +/- 0.07 min-1. 10(2), or the washout rate constant in the normal subjects, 0.46 +/- 0.17 min-1 x 10(2). The mean washout rate constant in NLS was 25% higher than the mean washout rate constant in the normal subjects. The difference was, however, not statistically significant. Differences in the washout rate constants might be due to abnormal subcutaneous tissue-to-blood partition (lambda) in the LS--and therefore not reflecting the real differences in the subcutaneous blood flow (SBF). The lambda for /sup 133/Xe was therefore measured--using a double isotope washout method (/sup 133/Xe and (/sup 131/I)antipyrine)--in symmetrical sites of the lateral crus in LS and NLS of 10 patients with psoriasis vulgaris and in 10 legs of normal subjects. In LS the lambda was 4.52 +/- 1.67 ml/g, which was not statistically different from that of NLS, 5.25 +/- 2.19 ml/g, nor from that of normal subcutaneous tissue, 4.98 +/- 1.04 ml/g. Calculations of the SBF using the obtained lambda values gave a significantly higher SBF in LS, 3.57 +/- 0.23 ml/100 g/min, compared to SBF in the NLS, 2.94 +/- 0.37 ml/100 g/min. There was no statistically significant difference between SBF in NLS and SBF in the normal subjects. The increased SBF in LS of psoriatics might be a secondary phenomenon to an increased heat loss in the lesional skin.

  5. Measurement of near-wall 3D flow velocity from wave-guiding micro-pillars.

    PubMed

    Bruecker, Christoph

    2016-09-19

    The measurement of near-wall flow in a plane close to the wall is achieved using the wave-guiding feature of transparent flexible micro-pillars which are attached in a 2D array to a surface and bend with the flow. Optical detection of bending from below the surface and application of auto-correlation methods provide mean and fluctuating part of the components of the wall-parallel velocity components. In addition, the wall-normal fluid motion is determined from spatial gradients in the array. The data provide the three-component velocity vector field in a plane close to the wall as well as their statistics. PMID:27661882

  6. Finite-difference model for 3-D flow in bays and estuaries

    USGS Publications Warehouse

    Smith, Peter E.; Larock, Bruce E.; ,

    1993-01-01

    This paper describes a semi-implicit finite-difference model for the numerical solution of three-dimensional flow in bays and estuaries. The model treats the gravity wave and vertical diffusion terms in the governing equations implicitly, and other terms explicitly. The model achieves essentially second-order accurate and stable solutions in strongly nonlinear problems by using a three-time-level leapfrog-trapezoidal scheme for the time integration.

  7. Locally modified QUICK scheme for highly convective 2-D and 3-D flows

    NASA Astrophysics Data System (ADS)

    Leonard, B. P.

    The positive and negative aspects of the QUICK scheme are discussed. QUICK is used in the bulk of the flow domain; however, when the local curvature of the convected variable exceeds a preset value, the algorithm switches to exponential upwinding or other compatible interpolation. Results are presented for the purely convective oblique-step test. A comparison is made between the sharp monotonic EULER-QUICK results and first-, second-, and third-order upwinding.

  8. Experimental investigation of 3-D turbulent free shear flow past propellers and windmills

    SciTech Connect

    Kotb, M.A.

    1984-01-01

    An experimental investigation of the flowfield region near a 0.49 m (1.615 ft), 3 bladed, horizontal axis rotor was conducted in the VPI 2 m x 2 m (6 ft x 6 ft) wind tunnel. Two different modes of operations were studied - propeller and windmill. For each case, tests were run with a uniform approach flow as a base line condition, and the main test series was run with a variable mesh wire grid upstream to produce an approach flow with an essentially linear velocity gradient. The results are compared to elucidate the effects of the non-uniform approach flow. Several types of measurements are reported. First are gross quantities such as overall thrust and power. The second type of measurements are mean (in the turbulence sense) quantities obtained with a five port yawhead tube. All three components of mean velocity and static pressure were obtained. The third type of measurements were made with an x-wire anemometer and an r.m.s. meter. These measurements yield all components of the turbulence intensities and stresses at a point averaged over many passes of the rotor blades.

  9. Perturbation solution for the viscoelastic 3D flow around a rigid sphere subject to simple shear

    NASA Astrophysics Data System (ADS)

    Housiadas, Kostas D.; Tanner, Roger I.

    2011-08-01

    We study the steady, three-dimensional creeping, and viscoelastic flow around a freely rotating rigid sphere subject to simple shear flow imposed at infinity. The viscoelasticity of the ambient fluid is modeled using the second-order-fluid model, the Upper Convected Maxwell, the exponential affine Phan-Thien-Tanner, and the Giesekus constitutive equations. A spherical coordinate system with origin at the center of the sphere is used to describe the flow field. The solution of the governing equations is expanded as a series for small values of the Deborah number. The resulting sequence of differential equations is solved analytically up to second order and numerically up to fourth order in Deborah number by employing fully spectral representations for all the primary variables. In particular, Chebyshev polynomials are used in the radial coordinate and the double Fourier series in the longitudinal and latitudinal coordinates. The numerical results up to second-order agree within machine accuracy with the available analytical solutions clearly indicating the correctness and accuracy of the numerical method developed here. Analytical expressions for the angular velocity of the rigid sphere up to fourth order, which show the slowdown of the rotation of the sphere with respect to the Newtonian creeping case, are also derived. For small Deborah numbers, these expressions, along with those presented in a recent letter [Housiadas and Tanner, Phys. Fluids 23, 051702 (2011)] are in agreement with the few available experimental data and numerical results.

  10. Measurement and analysis of flow in 3D preforms for aerospace composites

    NASA Astrophysics Data System (ADS)

    Stewart, Andrew Lawrence

    Composite materials have become viable alternatives to traditional engineering materials for many different product categories. Liquid transfer moulding (LTM) processes, specifically resin transfer moulding (RTM), is a cost-effective manufacturing technique for creating high performance composite parts. These parts can be tailor-made to their specific application by optimizing the properties of the textile preform. Preforms which require little or no further assembly work and are close to the shape of the final part are critical to obtaining high quality parts while simultaneously reducing labour and costs associated with other composite manufacturing techniques. One type of fabric which is well suited for near-net- shape preforms is stitched non-crimp fabrics. These fabrics offer very high in-plane strength and stiffness while also having increased resistance to delamination. Manufacturing parts from these dry preforms typically involves long-scale fluid flow through both open channels and porous fibre bundles. This thesis documents and analyzes the flow of fluid through preforms manufactured from non-crimp fabrics featuring through-thickness stitches. The objective of this research is to determine the effect of this type of stitch on the RTM injection process. All of the tests used preforms with fibre volume fractions representative of primary and secondary structural parts. A series of trials was conducted using different fibre materials, flow rates, fibre volumes fractions, and degrees of fibre consolidation. All of the trials were conducted for cases similar to RTM. Consolidation of the fibres showed improvements to both the thoroughness of the filling and to the fibre volume fraction. Experimentally determined permeability data was shown to trend well with simple models and precision of the permeability data was comparable to values presented by other authors who studied fabrics which did not feature the through-thickness stitches.

  11. 3-D Numerical Simulation for Gas-Liquid Two-Phase Flow in Aeration Tank

    NASA Astrophysics Data System (ADS)

    Xue, R.; Tian, R.; Yan, S. Y.; Li, S.

    In the crafts of activated sludge treatment, oxygen supply and the suspending state of activated sludge are primary factors to keep biochemistry process carrying on normally. However, they are all controlled by aeration. So aeration is crucial. The paper focus on aeration, use CFD software to simulate the field of aeration tank which is designed by sludge load method. The main designed size of aeration tank is: total volume: 20 000 m3; corridor width: 8m; total length of corridors: 139m; number of corridors: 3; length of one single corridor: 48m; effective depth: 4.5m; additional depth: 0.5m. According to the similarity theory, a geometrical model is set up in proportion of 10:1. The way of liquid flow is submerge to avoid liquid flow out directly. The grid is plotted by dividing the whole computational area into two parts. The bottom part which contains gas pipe and gas exit hole and the above part which is the main area are plotted by tetrahedron and hexahedron respectively. In boundary conditions, gas is defined as the primary-phase, and liquid is defined as the secondary-phase. Choosing mixture model, two-phase flow field of aeration tank is simulated by solved the Continuity equation for the mixture, Momentum equation for the mixture, Volume fraction equation for the secondary phases and Relative velocity formula when gas velocity is 10m/s, 20m/s, 30m/s. what figure shows is the contour of velocity magnitude for the mixture phase when gas velocity is 20m/s. Through analysis, the simulation tendency is agreed with actual running of aeration tank. It is feasible to use mixture model to simulate flow field of aeration tank by fluent software. According to the simulation result, the better velocity of liquid or gas (the quantity of inlet air) can be chosen by lower cost, and also the performance of aeration tank can be forecast. It will be helpful for designing and operation.

  12. Full potential solution of transonic quasi-3-D flow through a cascade using artificial compressability

    NASA Technical Reports Server (NTRS)

    Farrell, C.; Adamczyk, J.

    1981-01-01

    The three-dimensional flow in a turbomachinery blade row was approximated by correcting for streamtube convergence and radius change in the throughflow direction. The method is a fully conservative solution of the full potential equation incorporating the finite volume technique on body fitted periodic mesh, with an artificial density imposed in the transonic region to insure stability and the capture of shock waves. Comparison of results for several supercritical blades shows good agreement with their hodograph solutions. Other calculations for these profiles as well as standard NACA blade sections indicate that this is a useful scheme analyzing both the design and off-design performance of turbomachinery blading.

  13. Reflectional symmetry breaking of the separated flow over 3D bluff bodies

    NASA Astrophysics Data System (ADS)

    Grandemange, Mathieu; Gohlke, Marc; Cadot, Olivier

    2012-11-01

    The first experimental observation of a permanent reflectional symmetry breaking (RSB) is reported for a laminar three-dimensional wake. Based on flow visualizations, a first bifurcation from the trivial steady symmetric state to a steady RSB state is characterized at Re = 340. The RSB state becomes unsteady after a second bifurcation at Re = 410. It is found that this RSB regime is persistent at large Reynolds numbers and responsible for a bi-stable turbulent wake. The authors are indebted to R. Godoy Diana, V. Raspa and B. Thiria from ESPCI (Paris, France) for lending their low speed hydrodynamics tunnel.

  14. Preconditioned upwind methods to solve 3-D incompressible Navier-Stokes equations for viscous flows

    NASA Technical Reports Server (NTRS)

    Hsu, C.-H.; Chen, Y.-M.; Liu, C. H.

    1990-01-01

    A computational method for calculating low-speed viscous flowfields is developed. The method uses the implicit upwind-relaxation finite-difference algorithm with a nonsingular eigensystem to solve the preconditioned, three-dimensional, incompressible Navier-Stokes equations in curvilinear coordinates. The technique of local time stepping is incorporated to accelerate the rate of convergence to a steady-state solution. An extensive study of optimizing the preconditioned system is carried out for two viscous flow problems. Computed results are compared with analytical solutions and experimental data.

  15. Fabrication of continuous flow microfluidics device with 3D electrode structures for high throughput DEP applications using mechanical machining.

    PubMed

    Zeinali, Soheila; Çetin, Barbaros; Oliaei, Samad Nadimi Bavil; Karpat, Yiğit

    2015-07-01

    Microfluidics is the combination of micro/nano fabrication techniques with fluid flow at microscale to pursue powerful techniques in controlling and manipulating chemical and biological processes. Sorting and separation of bio-particles are highly considered in diagnostics and biological analyses. Dielectrophoresis (DEP) has offered unique advantages for microfluidic devices. In DEP devices, asymmetric pair of planar electrodes could be employed to generate non-uniform electric fields. In DEP applications, facing 3D sidewall electrodes is considered to be one of the key solutions to increase device throughput due to the generated homogeneous electric fields along the height of microchannels. Despite the advantages, fabrication of 3D vertical electrodes requires a considerable challenge. In this study, two alternative fabrication techniques have been proposed for the fabrication of a microfluidic device with 3D sidewall electrodes. In the first method, both the mold and the electrodes are fabricated using high precision machining. In the second method, the mold with tilted sidewalls is fabricated using high precision machining and the electrodes are deposited on the sidewall using sputtering together with a shadow mask fabricated by electric discharge machining. Both fabrication processes are assessed as highly repeatable and robust. Moreover, the two methods are found to be complementary with respect to the channel height. Only the manipulation of particles with negative-DEP is demonstrated in the experiments, and the throughput values up to 105 particles / min is reached in a continuous flow. The experimental results are compared with the simulation results and the limitations on the fabrication techniques are also discussed.

  16. Numerical simulation of 3D viscoelastic developing flow and heat transfer in a rectangular duct with a nonlinear constitutive equation

    NASA Astrophysics Data System (ADS)

    Jalali, A.; Hulsen, M. A.; Norouzi, M.; Kayhani, M. H.

    2013-05-01

    This paper presents a numerical simulation of the developing flow and heat transfer of a viscoelastic fluid in a rectangular duct. In fully developed flow of a viscoelastic fluid in a non-circular duct, secondary flows normal to the flow direction are expected to enhance the rate of heat and mass transfer. On the other hand, properties such as viscosity, thermal conductivity, specific heat and relaxation time of the fluid are a function of temperature. Therefore, we developed a numerical model which solves the flow and energy equation simultaneously in three dimensional form. We included several equations of state to model the temperature dependency of the fluid parameters. The current paper is one of the first studies which present a 3D numerical simulation for developing viscoelastic duct flow that takes the dependency of flow parameters to the temperature into account. The rheological constitutive equation of the fluid is a common form of the Phan-Thien Tanner (PTT) model, which embodies both influences of elasticity and shear thinning in viscosity. The governing equations are discretized using the FTCS finite difference method on a staggered mesh. The marker-and-cell method is also employed to allocate the parameters on the staggered mesh, and static pressure is calculated using the artificial compressibility approach during the numerical simulation. In addition to report the results of flow and heat transfer in the developing region, the effect of some dimensionless parameters on the flow and heat transfer has also been investigated. The results are in a good agreement with the results reported by others in this field.

  17. Numerical investigation of the 3D flow field generated by a self-propelling manta ray

    NASA Astrophysics Data System (ADS)

    Pederzani, Jean-Noel; Haj-Hariri, Hossein

    2010-11-01

    A mixed Lagrangian-Eulerian approach is used to solve the three dimensional Navier-Stokes equation around a self-propelling manta ray. The motion of the manta ray is prescribed using a kinematic model fitted to actual biological data. The dependence of thrust production mechanism on Strouhal and Reynolds numbers is investigated. The vortex core structures are accurately plotted using the λ2 criteria; and a correlation between wake structures and propulsive performance is established. This insight is critical in understanding the key flow features that a bio-inspired autonomous vehicle should reproduce in order to swim efficiently. The solution method is implemented on a block-structured Cartesian grid using a volume of fluid approach. To enhance the computational efficiency, a parallel adaptive mesh refinement technique is used. The present method is validated for the flow around a sphere. A basic station keeping control problem for a pitching and lagging wing is also analyzed to show the capability of the code to aid in controller design and stability analysis.

  18. Characterization of global flow and local fluctuations in 3D SPH simulations of protoplanetary discs

    NASA Astrophysics Data System (ADS)

    Arena, S. E.; Gonzalez, J.-F.

    2013-07-01

    A complete and detailed knowledge of the structure of the gaseous component in protoplanetary discs is essential to the study of dust evolution during the early phases of pre-planetesimal formation. The aim of this paper is to determine if three-dimensional accretion discs simulated by the smoothed particle hydrodynamics (SPH) method can reproduce the observational data now available and the expected turbulent nature of protoplanetary discs. The investigation is carried out by setting up a suite of diagnostic tools specifically designed to characterize both the global flow and the fluctuations of the gaseous disc. The main result concerns the role of the artificial viscosity implementation in the SPH method: in addition to the already known ability of SPH artificial viscosity to mimic a physical-like viscosity under specific conditions, we show how the same artificial viscosity prescription behaves like an implicit turbulence model. In fact, we identify a threshold for the parameters in the standard artificial viscosity above which SPH disc models present a cascade in the power spectrum of velocity fluctuations, turbulent diffusion and a mass accretion rate of the same order of magnitude as measured in observations. Furthermore, the turbulence properties observed locally in SPH disc models are accompanied by meridional circulation in the global flow of the gas, proving that the two mechanisms can coexist.

  19. 3D Mixing Inside a Neutrally Buoyant Drop Driven by Electrohydrodynamic Flows

    NASA Astrophysics Data System (ADS)

    Xu, Xiumei; Homsy, G. M.

    2007-11-01

    For a neutrally buoyant drop subjected to a uniform electric field, the internal flow is the well-known Taylor circulation. In Phys. Fluids 19 013102 (2007), we theoretically studied three dimensional mixing by periodically switching a uniform electric field through an angle α. Periodically switching the field is equivalent to periodically changing the symmetry axis of the Taylor circulation. For α=0.5 π, there is no chaotic mixing because the common heteroclinic trajectories form the separatrix of the flow. For other switching angles, chaotic advection is generated due to perturbations of the heteroclinic trajectory. Experimental investigations of mixing were carried out using a nearly isopycnic silicone oil/castor oil system. For α=0.5 π, our experiments show the existence of symmetry planes. In addition, two blobs of particles are observed to maintain almost invariant shapes for very long time, indicating the absence of chaotic mixing, as predicted by the theory. For other switching angles, experiments show the penetration of symmetry planes by tracer particles. However it is difficult to draw definitive conclusions regarding chaotic mixing because of charge relaxation, long initial transients and drop translation effects.

  20. A continuous flow microfluidic calorimeter: 3-D numerical modeling with aqueous reactants

    PubMed Central

    Sen, Mehmet A.; Kowalski, Gregory J.; Fiering, Jason; Larson, Dale

    2015-01-01

    A computational analysis of the reacting flow field, species diffusion and heat transfer processes with thermal boundary layer effects in a microchannel reactor with a coflow configuration was performed. Two parallel adjacent streams of aqueous reactants flow along a wide, shallow, enclosed channel in contact with a substrate, which is affixed to a temperature controlled plate. The Fluent computational fluid dynamics package solved the Navier–Stokes, mass transport and energy equations. The energy model, including the enthalpy of reaction as a nonuniform heat source, was validated by calculating the energy balance at several control volumes in the microchannel. Analysis reveals that the temperature is nearly uniform across the channel thickness, in the direction normal to the substrate surface; hence, measurements made by sensors at or near the surface are representative of the average temperature. Additionally, modeling the channel with a glass substrate and a silicone cover shows that heat transfer is predominantly due to the glass substrate. Finally, using the numerical results, we suggest that a microcalorimeter could be based on this configuration, and that temperature sensors such as optical nanohole array sensors could have sufficient spatial resolution to determine enthalpy of reaction. PMID:25937678

  1. Noise and Turbulence Generate 3D Zombie Vortices in Stably Stratified Rotating Shear Flows

    NASA Astrophysics Data System (ADS)

    Pei, Suyang; Marcus, Philip S.; Jiang, Chung-Hsiang; Hassanzadeh, Pedram; Lecoanet, Daniel; Barranco, Joseph A.

    2013-11-01

    We showed previously that a linearly stable shearing, rotating, stably stratified flow has a finite-amplitude instability creating ``zombie vortices'' that self-replicate and fill the domain. Our flows were initialized with perturbations of one or two vortices. Our motivation was to determine whether ``dead zones'' in protoplanetary disks were stable, or whether they could be de-stabilized to produce vortices necessary for the final part of star formation and for planet formation. To be more relevant to astrophysics, we choose the initial conditions to be noise or turbulence with a Kolmogorov spectrum with small kinetic energy and Mach number. In a Kolmogorov spectrum, the largest eddies determine the kinetic energy and Mach number, while the smallest determine the vorticity and Rossby number Ro ≡ ω / f , where ω is the vertical vorticity and f is the Coriolis parameter. The protoplanetary disks (which have large inertial ranges due to their large Reynolds numbers), can have large Rossby numbers, but weak Mach numbers and kinetic energies. It is important to know whether the triggering of the finite-amplitude instability that creates zombie vortices depends on threshold values of Mach number, kinetic energy, or the Rossby number. Here, we show it is the latter.

  2. Guidelines in the experimental validation of a 3D heat and fluid flow model of keyhole laser welding

    NASA Astrophysics Data System (ADS)

    Courtois, Mickael; Carin, Muriel; Le Masson, Philippe; Gaied, Sadok; Balabane, Mikhaël

    2016-04-01

    During the past few years, numerous sophisticated models have been proposed to predict in a self-consistent way the dynamics of the keyhole, together with the melt pool and vapor jet. However, these models are only partially compared to experimental data, so the reliability of these models is questionable. The present paper aims to propose a more complete experimental set-up in order to validate the most relevant results calculated by these models. A complete heat transfer and fluid flow three-dimensional (3D) model is first proposed in order to describe laser welding in keyhole regimes. The interface is tracked with a level set method and fluid flows are calculated in liquid and gas. The mechanisms of recoil pressure and keyhole creation are highlighted in a fusion line configuration chosen as a reference. Moreover, a complete validation of the model is proposed with guidelines on the variables to observe. Numerous comparisons with dedicated experiments (thermocouples, pyrometry, high-speed camera) are proposed to estimate the validity of the model. In addition to traditional geometric measurements, the main variables calculated, temperatures, and velocities in the melt pool are at the center of this work. The goal is to propose a reference validation for complex 3D models proposed over the last few years.

  3. 3D pressure imaging of an aircraft propeller blade-tip flow by phase-locked stereoscopic PIV

    NASA Astrophysics Data System (ADS)

    Ragni, D.; van Oudheusden, B. W.; Scarano, F.

    2012-02-01

    The flow field at the tip region of a scaled DHC Beaver aircraft propeller, running at transonic speed, has been investigated by means of a multi-plane stereoscopic particle image velocimetry setup. Velocity fields, phase-locked with the blade rotational motion, are acquired across several planes perpendicular to the blade axis and merged to form a 3D measurement volume. Transonic conditions have been reached at the tip region, with a revolution frequency of 19,800 rpm and a relative free-stream Mach number of 0.73 at the tip. The pressure field and the surface pressure distribution are inferred from the 3D velocity data through integration of the momentum Navier-Stokes equation in differential form, allowing for the simultaneous flow visualization and the aerodynamic loads computation, with respect to a reference frame moving with the blade. The momentum and pressure data are further integrated by means of a contour-approach to yield the aerodynamic sectional force components as well as the blade torsional moment. A steady Reynolds averaged Navier-Stokes numerical simulation of the entire propeller model has been used for comparison to the measurement data.

  4. Quasi 3D modelling of water flow in the sandy soil

    NASA Astrophysics Data System (ADS)

    Rezaei, Meisam; Seuntjens, Piet; Joris, Ingeborg; Boënne, Wesley; De Pue, Jan; Cornelis, Wim

    2016-04-01

    Monitoring and modeling tools may improve irrigation strategies in precision agriculture. Spatial interpolation is required for analyzing the effects of soil hydraulic parameters, soil layer thickness and groundwater level on irrigation management using hydrological models at field scale. We used non-invasive soil sensor, a crop growth (LINGRA-N) and a soil hydrological model (Hydrus-1D) to predict soil-water content fluctuations and crop yield in a heterogeneous sandy grassland soil under supplementary irrigation. In the first step, the sensitivity of the soil hydrological model to hydraulic parameters, water stress, crop yield and lower boundary conditions was assessed after integrating models at one soil column. Free drainage and incremental constant head conditions were implemented in a lower boundary sensitivity analysis. In the second step, to predict Ks over the whole field, the spatial distributions of Ks and its relationship between co-located soil ECa measured by a DUALEM-21S sensor were investigated. Measured groundwater levels and soil layer thickness were interpolated using ordinary point kriging (OK) to a 0.5 by 0.5 m in aim of digital elevation maps. In the third step, a quasi 3D modelling approach was conducted using interpolated data as input hydraulic parameter, geometric information and boundary conditions in the integrated model. In addition, three different irrigation scenarios namely current, no irrigation and optimized irrigations were carried out to find out the most efficient irrigation regime. In this approach, detailed field scale maps of soil water stress, water storage and crop yield were produced at each specific time interval to evaluate the best and most efficient distribution of water using standard gun sprinkler irrigation. The results show that the effect of the position of the groundwater level was dominant in soil-water content prediction and associated water stress. A time-dependent sensitivity analysis of the hydraulic

  5. Patterning process exploration of metal 1 layer in 7nm node with 3D patterning flow simulations

    NASA Astrophysics Data System (ADS)

    Gao, Weimin; Ciofi, Ivan; Saad, Yves; Matagne, Philippe; Bachmann, Michael; Oulmane, Mohamed; Gillijns, Werner; Lucas, Kevin; Demmerle, Wolfgang; Schmoeller, Thomas

    2015-03-01

    In 7mn node (N7), the logic design requires the critical poly pitch (CPP) of 42-45nm and metal 1 (M1) pitch of 28- 32nm. Such high pattern density pushes the 193 immersion lithography solution toward its limit and also brings extremely complex patterning scenarios. The N7 M1 layer may require a self-aligned quadruple patterning (SAQP) with triple litho-etch (LE3) block process. Therefore, the whole patterning process flow requires multiple exposure+etch+deposition processes and each step introduces a particular impact on the pattern profiles and the topography. In this study, we have successfully integrated a simulation tool that enables emulation of the whole patterning flow with realistic process-dependent 3D profile and topology. We use this tool to study the patterning process variations of N7 M1 layer including the overlay control, the critical dimension uniformity (CDU) budget and the lithographic process window (PW). The resulting 3D pattern structure can be used to optimize the process flow, verify design rules, extract parasitics, and most importantly, simulate the electric field and identify hot spots for dielectric reliability. As an example application, we will report extractions of maximum electric field at M1 tipto- tip which is one of the most critical patterning locations and we will demonstrate the potential of this approach for investigating the impact of process variations on dielectric reliability. We will also present simulations of an alternative M1 patterning flow, with a single exposure block using extreme ultraviolet lithography (EUVL) and analyze its advantages compared to the LE3 block approach.

  6. Code and Solution Verification of 3D Numerical Modeling of Flow in the Gust Erosion Chamber

    NASA Astrophysics Data System (ADS)

    Yuen, A.; Bombardelli, F. A.

    2014-12-01

    Erosion microcosms are devices commonly used to investigate the erosion and transport characteristics of sediments at the bed of rivers, lakes, or estuaries. In order to understand the results these devices provide, the bed shear stress and flow field need to be accurately described. In this research, the UMCES Gust Erosion Microcosm System (U-GEMS) is numerically modeled using Finite Volume Method. The primary aims are to simulate the bed shear stress distribution at the surface of the sediment core/bottom of the microcosm, and to validate the U-GEMS produces uniform bed shear stress at the bottom of the microcosm. The mathematical model equations are solved by on a Cartesian non-uniform grid. Multiple numerical runs were developed with different input conditions and configurations. Prior to developing the U-GEMS model, the General Moving Objects (GMO) model and different momentum algorithms in the code were verified. Code verification of these solvers was done via simulating the flow inside the top wall driven square cavity on different mesh sizes to obtain order of convergence. The GMO model was used to simulate the top wall in the top wall driven square cavity as well as the rotating disk in the U-GEMS. Components simulated with the GMO model were rigid bodies that could have any type of motion. In addition cross-verification was conducted as results were compared with numerical results by Ghia et al. (1982), and good agreement was found. Next, CFD results were validated by simulating the flow within the conventional microcosm system without suction and injection. Good agreement was found when the experimental results by Khalili et al. (2008) were compared. After the ability of the CFD solver was proved through the above code verification steps. The model was utilized to simulate the U-GEMS. The solution was verified via classic mesh convergence study on four consecutive mesh sizes, in addition to that Grid Convergence Index (GCI) was calculated and based on

  7. A 3D-PNS computer code for the calculation of supersonic combusting flows

    NASA Technical Reports Server (NTRS)

    Chitsomboon, Tawit; Northam, G. Burton

    1988-01-01

    A computer code has been developed based on the three-dimensional parabolized Navier-Stokes (PNS) equations which govern the supersonic combusting flow of the hydrogen-air system. The finite difference algorithm employed was a hybrid of the Schiff-Steger algorithm and the Vigneron, et al., algorithm which is fully implicit and fully coupled. The combustion of hydrogen and air was modeled by the finite-rate two-step combustion model of Rogers-Chinitz. A new dependent variable vector was introduced to simplify the numerical algorithm. Robustness of the algorithm was considerably enhanced by introducing an adjustable parameter. The computer code was used to solve a premixed shock-induced combustion problem and the results were compared with those of a full Navier-Stokes code. Reasonably good agreement was obtained at a fraction of the cost of the full Navier-Stokes procedure.

  8. Identification of groundwater parameters at Columbus, Mississippi, using a 3D inverse flow and transport model

    USGS Publications Warehouse

    Barlebo, H.C.; Rosbjerg, D.; Hill, M.C.

    1996-01-01

    An extensive amount of data including hydraulic heads, hydraulic conductivities and concentrations of several solutes from controlled injections have been collected during the MADE 1 and MADE 2 experiments at a heterogeneous site near Columbus, Mississippi. In this paper the use of three-dimensional inverse groundwater models including simultaneous estimation of flow and transport parameters is proposed to help identify the dominant characteristics at the site. Simulations show that using a hydraulic conductivity distribution obtained from 2187 borehole flowmeter tests directly in the model produces poor matches to the measured hydraulic heads and tritium concentrations. Alternatively, time averaged hydraulic head maps are used to define zones of constant hydraulic conductivity to be estimated. Preliminary simulations suggest that in the case of conservative transport many, but not all, of the major plume characteristics can be explained by large-scale heterogeneity in recharge and hydraulic conductivity.

  9. Full potential solution of a transonic quasi-3-D flow through a cascade using artificial compressibility

    NASA Technical Reports Server (NTRS)

    Farrell, C.; Adamczyk, J.

    1981-01-01

    A reliable method is presented for calculating the flowfield about a cascade of arbitrary 2-D airfoils. The method approximates the three-dimensional flow in a turbomachinery blade row by correcting for streamtube convergence and radius change in the throughflow direction. The method is a fully conservative solution of the full potential equation incorporating the finite volume technique on a body-fitted periodic mesh, with an artificial density imposed in the transonic region to ensure stability and the capture of shock waves. Comparison of results for several supercritical blades shows good agreement with their hodograph solutions. Other calculations for these profiles as well as standard NACA blade sections indicate that this is a useful scheme for analyzing both the design and off-design performance of turbomachinery blading.

  10. Intercomparison of 3D pore-scale flow and solute transport simulation methods

    SciTech Connect

    Mehmani, Yashar; Schoenherr, Martin; Pasquali, Andrea; Perkins, William A.; Kim, Kyungjoo; Perego, Mauro; Parks, Michael L.; Balhoff, Matthew T.; Richmond, Marshall C.; Geier, Martin; Krafczyk, Manfred; Luo, Li -Shi; Tartakovsky, Alexandre M.; Yang, Xiaofan; Scheibe, Timothy D.; Trask, Nathaniel

    2015-09-28

    Multiple numerical approaches have been developed to simulate porous media fluid flow and solute transport at the pore scale. These include 1) methods that explicitly model the three-dimensional geometry of pore spaces and 2) methods that conceptualize the pore space as a topologically consistent set of stylized pore bodies and pore throats. In previous work we validated a model of the first type, using computational fluid dynamics (CFD) codes employing a standard finite volume method (FVM), against magnetic resonance velocimetry (MRV) measurements of pore-scale velocities. Here we expand that validation to include additional models of the first type based on the lattice Boltzmann method (LBM) and smoothed particle hydrodynamics (SPH), as well as a model of the second type, a pore-network model (PNM). The PNM approach used in the current study was recently improved and demonstrated to accurately simulate solute transport in a two-dimensional experiment. While the PNM approach is computationally much less demanding than direct numerical simulation methods, the effect of conceptualizing complex three-dimensional pore geometries on solute transport in the manner of PNMs has not been fully determined. We apply all four approaches (FVM-based CFD, LBM, SPH and PNM) to simulate pore-scale velocity distributions and (for capable codes) nonreactive solute transport, and intercompare the model results. Comparisons are drawn both in terms of macroscopic variables (e.g., permeability, solute breakthrough curves) and microscopic variables (e.g., local velocities and concentrations). Generally good agreement was achieved among the various approaches, but some differences were observed depending on the model context. The intercomparison work was challenging because of variable capabilities of the codes, and inspired some code enhancements to allow consistent comparison of flow and transport simulations across the full suite of methods. This paper provides support for confidence

  11. Intercomparison of 3D pore-scale flow and solute transport simulation methods

    DOE PAGES

    Mehmani, Yashar; Schoenherr, Martin; Pasquali, Andrea; Perkins, William A.; Kim, Kyungjoo; Perego, Mauro; Parks, Michael L.; Balhoff, Matthew T.; Richmond, Marshall C.; Geier, Martin; et al

    2015-09-28

    Multiple numerical approaches have been developed to simulate porous media fluid flow and solute transport at the pore scale. These include 1) methods that explicitly model the three-dimensional geometry of pore spaces and 2) methods that conceptualize the pore space as a topologically consistent set of stylized pore bodies and pore throats. In previous work we validated a model of the first type, using computational fluid dynamics (CFD) codes employing a standard finite volume method (FVM), against magnetic resonance velocimetry (MRV) measurements of pore-scale velocities. Here we expand that validation to include additional models of the first type based onmore » the lattice Boltzmann method (LBM) and smoothed particle hydrodynamics (SPH), as well as a model of the second type, a pore-network model (PNM). The PNM approach used in the current study was recently improved and demonstrated to accurately simulate solute transport in a two-dimensional experiment. While the PNM approach is computationally much less demanding than direct numerical simulation methods, the effect of conceptualizing complex three-dimensional pore geometries on solute transport in the manner of PNMs has not been fully determined. We apply all four approaches (FVM-based CFD, LBM, SPH and PNM) to simulate pore-scale velocity distributions and (for capable codes) nonreactive solute transport, and intercompare the model results. Comparisons are drawn both in terms of macroscopic variables (e.g., permeability, solute breakthrough curves) and microscopic variables (e.g., local velocities and concentrations). Generally good agreement was achieved among the various approaches, but some differences were observed depending on the model context. The intercomparison work was challenging because of variable capabilities of the codes, and inspired some code enhancements to allow consistent comparison of flow and transport simulations across the full suite of methods. This paper provides support for

  12. Benchmark Study of 3D Pore-scale Flow and Solute Transport Simulation Methods

    NASA Astrophysics Data System (ADS)

    Scheibe, T. D.; Yang, X.; Mehmani, Y.; Perkins, W. A.; Pasquali, A.; Schoenherr, M.; Kim, K.; Perego, M.; Parks, M. L.; Trask, N.; Balhoff, M.; Richmond, M. C.; Geier, M.; Krafczyk, M.; Luo, L. S.; Tartakovsky, A. M.

    2015-12-01

    Multiple numerical approaches have been developed to simulate porous media fluid flow and solute transport at the pore scale. These include 1) methods that explicitly model the three-dimensional geometry of pore spaces and 2) methods that conceptualize the pore space as a topologically consistent set of stylized pore bodies and pore throats. In previous work we validated a model of the first type, using computational fluid dynamics (CFD) codes employing standard finite volume method (FVM), against magnetic resonance velocimetry (MRV) measurements of pore-scale velocities. Here we expand that benchmark study to include additional models of the first type based on the immersed-boundary method (IMB), lattice Boltzmann method (LBM), and smoothed particle hydrodynamics (SPH), as well as a model of the second type, a pore-network model (PNM). While the PNM approach is computationally much less demanding than direct numerical simulation methods, the effect of conceptualizing complex three-dimensional pore geometries in the manner of PNMs has not been fully determined. We apply all five approaches (FVM-based CFD, IMB, LBM, SPH and PNM) to simulate pore-scale velocity distributions and nonreactive solute transport, and intercompare the model results. Comparisons are drawn both in terms of macroscopic variables (e.g., permeability, solute breakthrough curves) and microscopic variables (e.g., local velocities and concentrations). Generally good agreement was achieved among the various approaches, but some differences were observed depending on the model context. The benchmark study was challenging because of variable capabilities of the codes, and inspired some code enhancements to allow consistent comparison of flow and transport simulations across the full suite of methods. This study provides support for confidence in a variety of pore-scale modeling methods, and motivates further development and application of pore-scale simulation methods.

  13. Intercomparison of 3D pore-scale flow and solute transport simulation methods

    NASA Astrophysics Data System (ADS)

    Yang, Xiaofan; Mehmani, Yashar; Perkins, William A.; Pasquali, Andrea; Schönherr, Martin; Kim, Kyungjoo; Perego, Mauro; Parks, Michael L.; Trask, Nathaniel; Balhoff, Matthew T.; Richmond, Marshall C.; Geier, Martin; Krafczyk, Manfred; Luo, Li-Shi; Tartakovsky, Alexandre M.; Scheibe, Timothy D.

    2016-09-01

    Multiple numerical approaches have been developed to simulate porous media fluid flow and solute transport at the pore scale. These include 1) methods that explicitly model the three-dimensional geometry of pore spaces and 2) methods that conceptualize the pore space as a topologically consistent set of stylized pore bodies and pore throats. In previous work we validated a model of the first type, using computational fluid dynamics (CFD) codes employing a standard finite volume method (FVM), against magnetic resonance velocimetry (MRV) measurements of pore-scale velocities. Here we expand that validation to include additional models of the first type based on the lattice Boltzmann method (LBM) and smoothed particle hydrodynamics (SPH), as well as a model of the second type, a pore-network model (PNM). The PNM approach used in the current study was recently improved and demonstrated to accurately simulate solute transport in a two-dimensional experiment. While the PNM approach is computationally much less demanding than direct numerical simulation methods, the effect of conceptualizing complex three-dimensional pore geometries on solute transport in the manner of PNMs has not been fully determined. We apply all four approaches (FVM-based CFD, LBM, SPH and PNM) to simulate pore-scale velocity distributions and (for capable codes) nonreactive solute transport, and intercompare the model results. Comparisons are drawn both in terms of macroscopic variables (e.g., permeability, solute breakthrough curves) and microscopic variables (e.g., local velocities and concentrations). Generally good agreement was achieved among the various approaches, but some differences were observed depending on the model context. The intercomparison work was challenging because of variable capabilities of the codes, and inspired some code enhancements to allow consistent comparison of flow and transport simulations across the full suite of methods. This study provides support for confidence

  14. Radioisotopic flow scanning for portal blood flow and portal hypertension

    SciTech Connect

    Hesdorffer, C.S.; Bezwoda, W.R.; Danilewitz, M.D.; Esser, J.D.; Tobias, M.

    1987-08-01

    The use of a simple, noninvasive, isotope scanning technique for the determination of relative portal blood flow and detection of portal hypertension is described. Using this technique the presence of portal hypertension was demonstrated in seven of nine patients known to have elevated portal venous pressure. By contrast, esophageal varices were demonstrated in only five of these patients, illustrating the potential value of the method. Furthermore, this technique has been adapted to the study of portal blood flow in patients with myeloproliferative disorders with splenomegaly but without disturbances in hepatic architecture. Results demonstrate that the high relative splenic flow resulting from the presence of splenomegaly may in turn be associated with elevated relative portal blood flow and portal hypertension. The theoretic reasons for the development of flow-related portal hypertension and its relationship to splenic blood flow are discussed.

  15. Rheological effects in the 3D creeping flow past a sedimenting sphere subject to orthogonal shear

    NASA Astrophysics Data System (ADS)

    Housiadas, Kostas D.; Tanner, Roger I.

    2014-01-01

    The effects of the rheological parameters of nonlinear differential constitutive models in the isothermal, steady, creeping, flow past a sedimenting sphere, in an incompressible viscoelastic matrix fluid, subject to simple shear in a plane perpendicular to the direction of sedimentation are studied analytically. The viscoelasticity of the ambient fluid is modeled using the Upper Convected Maxwell, Oldroyd-B, exponential Phan-Thien-Tanner, Giesekus, and FENE-P constitutive equations. The solution of the governing equations is expanded as a regular perturbation series for small values of the Deborah number, and the resulting sequence of three-dimensional partial differential equations is solved analytically up to fourth order. Approximate analytical expressions for the angular velocity of the rigid sphere, as well as for the drag force on the sphere, are derived and discussed. The solutions reveal both the increase of the drag in case of Boger-type fluids (modeled with the FENE-P model) and the decrease of the drag in case of elastic fluids (modeled with the Giesekus model).

  16. A numerical investigation of the 3-D flow in shell and tube heat exchangers

    SciTech Connect

    Prithiviraj, M.; Andrews, M.J.

    1996-12-31

    A three-dimensional computer program for simulation of the flow and heat transfer inside Shell and Tube Heat Exchangers has been developed. The simulation of shell and tube heat exchangers is based on a distributed resistance method that uses a modified two equation {kappa}-{epsilon} turbulence model along with non-equilibrium wall functions. Volume porosities and non-homogeneous surface permeabilities account for the obstructions due to the tubes and arbitrary arrangement of baffles. Sub-models are described for baffle-shell and baffle-tube leakage, shellside and tubeside heat transfer, with geometry generators for tubes, baffles, and nozzle inlets and outlets. The sub-models in HEATX use parameters that have not been altered from their published values. Computed heat transfer and pressure drop are compared with experimental data from the Delaware project (Bell, 1963). Numerically computed pressure drops are also compared for different baffle cuts, and different number of baffles with the experiments of Halle et al. (1984) which were performed in an industrial sized heat exchanger at Argonne National Labs. Discussion of the results is given with particular reference to global and local properties such as pressure drop, temperature variation, and heat transfer coefficients. Good agreement is obtained between the experiments and HEATX computations for the shellside pressure drop and outlet temperatures for the shellside and tubeside streams.

  17. 3D ultrafast ultrasound imaging in vivo.

    PubMed

    Provost, Jean; Papadacci, Clement; Arango, Juan Esteban; Imbault, Marion; Fink, Mathias; Gennisson, Jean-Luc; Tanter, Mickael; Pernot, Mathieu

    2014-10-01

    Very high frame rate ultrasound imaging has recently allowed for the extension of the applications of echography to new fields of study such as the functional imaging of the brain, cardiac electrophysiology, and the quantitative imaging of the intrinsic mechanical properties of tumors, to name a few, non-invasively and in real time. In this study, we present the first implementation of Ultrafast Ultrasound Imaging in 3D based on the use of either diverging or plane waves emanating from a sparse virtual array located behind the probe. It achieves high contrast and resolution while maintaining imaging rates of thousands of volumes per second. A customized portable ultrasound system was developed to sample 1024 independent channels and to drive a 32  ×  32 matrix-array probe. Its ability to track in 3D transient phenomena occurring in the millisecond range within a single ultrafast acquisition was demonstrated for 3D Shear-Wave Imaging, 3D Ultrafast Doppler Imaging, and, finally, 3D Ultrafast combined Tissue and Flow Doppler Imaging. The propagation of shear waves was tracked in a phantom and used to characterize its stiffness. 3D Ultrafast Doppler was used to obtain 3D maps of Pulsed Doppler, Color Doppler, and Power Doppler quantities in a single acquisition and revealed, at thousands of volumes per second, the complex 3D flow patterns occurring in the ventricles of the human heart during an entire cardiac cycle, as well as the 3D in vivo interaction of blood flow and wall motion during the pulse wave in the carotid at the bifurcation. This study demonstrates the potential of 3D Ultrafast Ultrasound Imaging for the 3D mapping of stiffness, tissue motion, and flow in humans in vivo and promises new clinical applications of ultrasound with reduced intra--and inter-observer variability.

  18. 3D ultrafast ultrasound imaging in vivo

    NASA Astrophysics Data System (ADS)

    Provost, Jean; Papadacci, Clement; Esteban Arango, Juan; Imbault, Marion; Fink, Mathias; Gennisson, Jean-Luc; Tanter, Mickael; Pernot, Mathieu

    2014-10-01

    Very high frame rate ultrasound imaging has recently allowed for the extension of the applications of echography to new fields of study such as the functional imaging of the brain, cardiac electrophysiology, and the quantitative imaging of the intrinsic mechanical properties of tumors, to name a few, non-invasively and in real time. In this study, we present the first implementation of Ultrafast Ultrasound Imaging in 3D based on the use of either diverging or plane waves emanating from a sparse virtual array located behind the probe. It achieves high contrast and resolution while maintaining imaging rates of thousands of volumes per second. A customized portable ultrasound system was developed to sample 1024 independent channels and to drive a 32  ×  32 matrix-array probe. Its ability to track in 3D transient phenomena occurring in the millisecond range within a single ultrafast acquisition was demonstrated for 3D Shear-Wave Imaging, 3D Ultrafast Doppler Imaging, and, finally, 3D Ultrafast combined Tissue and Flow Doppler Imaging. The propagation of shear waves was tracked in a phantom and used to characterize its stiffness. 3D Ultrafast Doppler was used to obtain 3D maps of Pulsed Doppler, Color Doppler, and Power Doppler quantities in a single acquisition and revealed, at thousands of volumes per second, the complex 3D flow patterns occurring in the ventricles of the human heart during an entire cardiac cycle, as well as the 3D in vivo interaction of blood flow and wall motion during the pulse wave in the carotid at the bifurcation. This study demonstrates the potential of 3D Ultrafast Ultrasound Imaging for the 3D mapping of stiffness, tissue motion, and flow in humans in vivo and promises new clinical applications of ultrasound with reduced intra—and inter-observer variability.

  19. 3D ultrafast ultrasound imaging in vivo.

    PubMed

    Provost, Jean; Papadacci, Clement; Arango, Juan Esteban; Imbault, Marion; Fink, Mathias; Gennisson, Jean-Luc; Tanter, Mickael; Pernot, Mathieu

    2014-10-01

    Very high frame rate ultrasound imaging has recently allowed for the extension of the applications of echography to new fields of study such as the functional imaging of the brain, cardiac electrophysiology, and the quantitative imaging of the intrinsic mechanical properties of tumors, to name a few, non-invasively and in real time. In this study, we present the first implementation of Ultrafast Ultrasound Imaging in 3D based on the use of either diverging or plane waves emanating from a sparse virtual array located behind the probe. It achieves high contrast and resolution while maintaining imaging rates of thousands of volumes per second. A customized portable ultrasound system was developed to sample 1024 independent channels and to drive a 32  ×  32 matrix-array probe. Its ability to track in 3D transient phenomena occurring in the millisecond range within a single ultrafast acquisition was demonstrated for 3D Shear-Wave Imaging, 3D Ultrafast Doppler Imaging, and, finally, 3D Ultrafast combined Tissue and Flow Doppler Imaging. The propagation of shear waves was tracked in a phantom and used to characterize its stiffness. 3D Ultrafast Doppler was used to obtain 3D maps of Pulsed Doppler, Color Doppler, and Power Doppler quantities in a single acquisition and revealed, at thousands of volumes per second, the complex 3D flow patterns occurring in the ventricles of the human heart during an entire cardiac cycle, as well as the 3D in vivo interaction of blood flow and wall motion during the pulse wave in the carotid at the bifurcation. This study demonstrates the potential of 3D Ultrafast Ultrasound Imaging for the 3D mapping of stiffness, tissue motion, and flow in humans in vivo and promises new clinical applications of ultrasound with reduced intra--and inter-observer variability. PMID:25207828

  20. Field observations of swash zone flow patterns and 3D morphodynamics

    USGS Publications Warehouse

    Puelo, Jack A.; Holland, K. Todd; Kooney, Timothy N.; Sallenger,, Asbury H.; Edge, Billy L.

    2001-01-01

    Rapid video measurements of foreshore morphology and velocity were collected at Duck, NC in 1997 to investigate sediment transport processes in the swash zone. Estimates of foreshore evolution over a roughly 30 m cross-shore by 80 m alongshore study area were determined using a stereogrammetric technique. During the passage of a small storm (offshore wave heights increased from 1.4 to 2.5 m), the foreshore eroded nearly 40 cm in less than 4 hours. Dense, horizontal surface velocities were measured over a sub-region (roughly 30 m by 40 m) of the study area using a new particle image velocimetry technique. This technique was able to quantify velocities across the bore front approaching 5 m s–1 as well as the rapid velocities in the very shallow backwash flows. The velocity and foreshore topography measurements were used to test a three-dimensional energetics-based sediment transport model. Even though these data represent the most extensive and highly resolved swash measurements to date, the results showed that while the model could predict some of the qualitative trends in the observed foreshore change, it was a poor predictor of the observed magnitudes of foreshore change. Model — data comparisons differed by roughly an order of magnitude with observed foreshore changes on the order of 10's of centimeters and model predictions on the order of meters. This poor comparison suggests that future models of swash-zone sediment transport may require the inclusion of other physical processes such as bore turbulence, fluid accelerations and skewness, infiltration/exfiltration, water depth variations, and variable friction factors (to name a few).

  1. Breakup of Finite-Size Colloidal Aggregates in Turbulent Flow Investigated by Three-Dimensional (3D) Particle Tracking Velocimetry.

    PubMed

    Saha, Debashish; Babler, Matthaus U; Holzner, Markus; Soos, Miroslav; Lüthi, Beat; Liberzon, Alex; Kinzelbach, Wolfgang

    2016-01-12

    Aggregates grown in mild shear flow are released, one at a time, into homogeneous isotropic turbulence, where their motion and intermittent breakup is recorded by three-dimensional particle tracking velocimetry (3D-PTV). The aggregates have an open structure with a fractal dimension of ∼2.2, and their size is 1.4 ± 0.4 mm, which is large, compared to the Kolmogorov length scale (η = 0.15 mm). 3D-PTV of flow tracers allows for the simultaneous measurement of aggregate trajectories and the full velocity gradient tensor along their pathlines, which enables us to access the Lagrangian stress history of individual breakup events. From this data, we found no consistent pattern that relates breakup to the local flow properties at the point of breakup. Also, the correlation between the aggregate size and both shear stress and normal stress at the location of breakage is found to be weaker, when compared with the correlation between size and drag stress. The analysis suggests that the aggregates are mostly broken due to the accumulation of the drag stress over a time lag on the order of the Kolmogorov time scale. This finding is explained by the fact that the aggregates are large, which gives their motion inertia and increases the time for stress propagation inside the aggregate. Furthermore, it is found that the scaling of the largest fragment and the accumulated stress at breakup follows an earlier established power law, i.e., dfrag ∼ σ(-0.6) obtained from laminar nozzle experiments. This indicates that, despite the large size and the different type of hydrodynamic stress, the microscopic mechanism causing breakup is consistent over a wide range of aggregate size and stress magnitude. PMID:26646289

  2. Implicit finite volume and discontinuous Galerkin methods for multicomponent flow in unstructured 3D fractured porous media

    NASA Astrophysics Data System (ADS)

    Moortgat, Joachim; Amooie, Mohammad Amin; Soltanian, Mohamad Reza

    2016-10-01

    We present a new implicit higher-order finite element (FE) approach to efficiently model compressible multicomponent fluid flow on unstructured grids and in fractured porous subsurface formations. The scheme is sequential implicit: pressures and fluxes are updated with an implicit Mixed Hybrid Finite Element (MHFE) method, and the transport of each species is approximated with an implicit second-order Discontinuous Galerkin (DG) FE method. Discrete fractures are incorporated with a cross-flow equilibrium approach. This is the first investigation of all-implicit higher-order MHFE-DG for unstructured triangular, quadrilateral (2D), and hexahedral (3D) grids and discrete fractures. A lowest-order implicit finite volume (FV) transport update is also developed for the same grid types. The implicit methods are compared to an Implicit-Pressure-Explicit-Composition (IMPEC) scheme. For fractured domains, the unconditionally stable implicit transport update is shown to increase computational efficiency by orders of magnitude as compared to IMPEC, which has a time-step constraint proportional to the pore volume of discrete fracture grid cells. However, when lowest-order Euler time-discretizations are used, numerical errors increase linearly with the larger implicit time-steps, resulting in high numerical dispersion. Second-order Crank-Nicolson implicit MHFE-DG and MHFE-FV are therefore presented as well. Convergence analyses show twice the convergence rate for the DG methods as compared to FV, resulting in two to three orders of magnitude higher computational efficiency. Numerical experiments demonstrate the efficiency and robustness in modeling compressible multicomponent flow on irregular and fractured 2D and 3D grids, even in the presence of fingering instabilities.

  3. Breakup of Finite-Size Colloidal Aggregates in Turbulent Flow Investigated by Three-Dimensional (3D) Particle Tracking Velocimetry.

    PubMed

    Saha, Debashish; Babler, Matthaus U; Holzner, Markus; Soos, Miroslav; Lüthi, Beat; Liberzon, Alex; Kinzelbach, Wolfgang

    2016-01-12

    Aggregates grown in mild shear flow are released, one at a time, into homogeneous isotropic turbulence, where their motion and intermittent breakup is recorded by three-dimensional particle tracking velocimetry (3D-PTV). The aggregates have an open structure with a fractal dimension of ∼2.2, and their size is 1.4 ± 0.4 mm, which is large, compared to the Kolmogorov length scale (η = 0.15 mm). 3D-PTV of flow tracers allows for the simultaneous measurement of aggregate trajectories and the full velocity gradient tensor along their pathlines, which enables us to access the Lagrangian stress history of individual breakup events. From this data, we found no consistent pattern that relates breakup to the local flow properties at the point of breakup. Also, the correlation between the aggregate size and both shear stress and normal stress at the location of breakage is found to be weaker, when compared with the correlation between size and drag stress. The analysis suggests that the aggregates are mostly broken due to the accumulation of the drag stress over a time lag on the order of the Kolmogorov time scale. This finding is explained by the fact that the aggregates are large, which gives their motion inertia and increases the time for stress propagation inside the aggregate. Furthermore, it is found that the scaling of the largest fragment and the accumulated stress at breakup follows an earlier established power law, i.e., dfrag ∼ σ(-0.6) obtained from laminar nozzle experiments. This indicates that, despite the large size and the different type of hydrodynamic stress, the microscopic mechanism causing breakup is consistent over a wide range of aggregate size and stress magnitude.

  4. Mixed-hybrid and vertex-discontinuous-Galerkin finite element modeling of multiphase compositional flow on 3D unstructured grids

    NASA Astrophysics Data System (ADS)

    Moortgat, Joachim; Firoozabadi, Abbas

    2016-06-01

    Problems of interest in hydrogeology and hydrocarbon resources involve complex heterogeneous geological formations. Such domains are most accurately represented in reservoir simulations by unstructured computational grids. Finite element methods accurately describe flow on unstructured meshes with complex geometries, and their flexible formulation allows implementation on different grid types. In this work, we consider for the first time the challenging problem of fully compositional three-phase flow in 3D unstructured grids, discretized by any combination of tetrahedra, prisms, and hexahedra. We employ a mass conserving mixed hybrid finite element (MHFE) method to solve for the pressure and flux fields. The transport equations are approximated with a higher-order vertex-based discontinuous Galerkin (DG) discretization. We show that this approach outperforms a face-based implementation of the same polynomial order. These methods are well suited for heterogeneous and fractured reservoirs, because they provide globally continuous pressure and flux fields, while allowing for sharp discontinuities in compositions and saturations. The higher-order accuracy improves the modeling of strongly non-linear flow, such as gravitational and viscous fingering. We review the literature on unstructured reservoir simulation models, and present many examples that consider gravity depletion, water flooding, and gas injection in oil saturated reservoirs. We study convergence rates, mesh sensitivity, and demonstrate the wide applicability of our chosen finite element methods for challenging multiphase flow problems in geometrically complex subsurface media.

  5. Experimental Investigation of Three-Dimensional (3-D) Material Flow Pattern in Thick Dissimilar 2050 Friction-Stir Welds

    NASA Astrophysics Data System (ADS)

    Avettand-Fènoël, Marie-Noëlle; Taillard, Roland; Laye, Julien; Odièvre, Thierry

    2014-02-01

    The current microstructural investigation performed at various scales deals with the three-dimensional (3-D) material flow in thick dissimilar Airware™ 2050 friction-stir butt welds (Airware, Newport Beach, CA) because of the scarcity of the results obtained with thicker than 8 mm joints and the lack of detailed interpretation of features in the longitudinal direction. An additional originality consists in the study of material flow under the probe tip. In the current case of thick plates, the variation of local temperature along the weld depth is of key importance for the material flow. Indeed, it governs the slight difference of local mechanical behavior between both materials and therefore the shift of the interface, which was clearly put into evidence by means of a difference of Mn content as small as 0.3 pct between both alloys. This importance of temperature for the malleability also entails the pear shape of the nugget as well as a change of grains orientation along the depth in the thermomechanically affected zone. Due to the modification of tool-material adhesion with temperature, a new phenomenological model of material flow for thick friction-stir welds is proposed. In accordance with their difference of origin, the coexistence of onion rings and serrated interface is also highlighted.

  6. Numerical Simulation of 3D particulate flow by Coupling Multi-Fluid Model with Discrete Element Method

    NASA Astrophysics Data System (ADS)

    Guo, Liancheng; Morita, Koji; Tagami, Hirotaka; Tobita, Yoshiharu

    2014-06-01

    The postulated core disruptive accidents (CDAs) are regarded as particular difficulties in the safety analysis of liquid-metal fast reactors (LMFRs). In CDAs, the motions and interactions of solid particles, such as refrozen fuels, disrupted pellets, etc., not only dominate fundamental behaviors of multiphase flows, but also drastically influence the process of CDAs. The fast reactor safety analysis code, SIMMER-IV, which is a 3D, multi-velocity-field, multiphase, multicomponent, Eulerian, fluid dynamics code coupled with a fuel-pin model and a space- and energy-dependent neutron kinetics model, was successfully applied to a series of CDA assessments. However, strong interactions among solid particles as well as particle characteristics in multiphase flows with rich solid particles were not taken into consideration for fluid-dynamics models of SIMMER-IV. In this article, a hybrid method for multiphase flow analysis is developed by coupling the discrete element method (DEM) with the multi-fluid model of SIMMER-IV. In the coupling algorithm, motions of liquid and gas phases are solved by a time-factorization (time-splitting) method. For the solid phases, contacts among particles and interactions with fluid phases are considered through DEM. Numerical simulations of dam-break behavior with rich solid particles show reasonable agreements with corresponding experimental results. It is expected that SIMMER-IV coupled with DEM could provide a promising and useful computational tool for complicated multiphase-flow phenomena with high concentration of solid particles.

  7. Dual FIB-SEM 3D Imaging and Lattice Boltzmann Modeling of Porosimetry and Multiphase Flow in Chalk

    NASA Astrophysics Data System (ADS)

    Rinehart, A. J.; Yoon, H.; Dewers, T. A.; Heath, J. E.; Petrusak, R.

    2010-12-01

    Mercury intrusion porosimetry (MIP) is an often-applied technique for determining pore throat distributions and seal analysis of fine-grained rocks. Due to closure effects, potential pore collapse, and complex pore network topologies, MIP data interpretation can be ambiguous, and often biased toward smaller pores in the distribution. We apply 3D imaging techniques and lattice-Boltzmann modeling in interpreting MIP data for samples of the Cretaceous Selma Group Chalk. In the Mississippi Interior Salt Basin, the Selma Chalk is the apparent seal for oil and gas fields in the underlying Eutaw Fm., and, where unfractured, the Selma Chalk is one of the regional-scale seals identified by the Southeast Regional Carbon Sequestration Partnership for CO2 injection sites. Dual focused ion - scanning electron beam and laser scanning confocal microscopy methods are used for 3D imaging of nanometer-to-micron scale microcrack and pore distributions in the Selma Chalk. A combination of image analysis software is used to obtain geometric pore body and throat distributions and other topological properties, which are compared to MIP results. 3D data sets of pore-microfracture networks are used in Lattice Boltzmann simulations of drainage (wetting fluid displaced by non-wetting fluid via the Shan-Chen algorithm), which in turn are used to model MIP procedures. Results are used in interpreting MIP results, understanding microfracture-matrix interaction during multiphase flow, and seal analysis for underground CO2 storage. This work was supported by the US Department of Energy, Office of Basic Energy Sciences as part of an Energy Frontier Research Center. Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Company, for the U.S. Department of Energy’s National Nuclear Security Administration under contract DE-AC04-94AL85000.

  8. Applying and validating the RANS-3D flow-solver for evaluating a subsonic serpentine diffuser geometry

    NASA Technical Reports Server (NTRS)

    Fletcher, Michael J.; Won, Mark J.; Cosentino, Gary B.; Te, Alexander

    1993-01-01

    Subsonic inlet ducts for advanced, high-performance aircraft are evolving towards complex three-dimensional shapes for reasons of overall integration and weight. These factors lead to diffuser geometries that may sacrifice inlet performance, unless careful attention to design details and boundary layer management techniques are employed. The ability of viscous computational fluid dynamic (CFD) analysis of such geometries to aid the aircraft configurator in this complex design problem is herein examined. The RANS-3D Reynolds-Averaged Navier-Stokes solver is applied to model the complex flowfield occurring in a representative diffuser geometry and the solutions are compared to experimental results from a static test of the inlet duct. The computational results are shown to compare very favorably with experimental results over a range of mass flow rates, including those involving large amounts of separation in the diffuser. In addition, a novel grid topology is presented, and two turbulence models are evaluated in this study as part of the RANS-3D code.

  9. Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study

    PubMed Central

    Lim, Jong-Min; Bertrand, Nicolas; Valencia, Pedro M.; Rhee, Minsoung; Langer, Robert; Jon, Sangyong; Farokhzad, Omid C.; Karnik, Rohit

    2014-01-01

    Microfluidic synthesis of nanoparticles (NPs) can enhance the controllability and reproducibility in physicochemical properties of NPs compared to bulk synthesis methods. However, applications of microfluidic synthesis are typically limited to in vitro studies due to low production rates. Herein, we report the parallelization of NP synthesis by 3D hydrodynamic flow focusing (HFF) using a multilayer microfluidic system to enhance the production rate without losing the advantages of reproducibility, controllability, and robustness. Using parallel 3D HFF, polymeric poly(lactide-co-glycolide)-b-polyethyleneglycol (PLGA-PEG) NPs with sizes tunable in the range of 13–150 nm could be synthesized reproducibly with high production rate. As a proof of concept, we used this system to perform in vivo pharmacokinetic and biodistribution study of small (20 nm diameter) PLGA-PEG NPs that are otherwise difficult to synthesize. Microfluidic parallelization thus enables synthesis of NPs with tunable properties with production rates suitable for both in vitro and in vivo studies. PMID:23969105

  10. Symmetry-plane model of 3D Euler flows: Mapping to regular systems and numerical solutions of blowup

    NASA Astrophysics Data System (ADS)

    Mulungye, Rachel M.; Lucas, Dan; Bustamante, Miguel D.

    2014-11-01

    We introduce a family of 2D models describing the dynamics on the so-called symmetry plane of the full 3D Euler fluid equations. These models depend on a free real parameter and can be solved analytically. For selected representative values of the free parameter, we apply the method introduced in [M.D. Bustamante, Physica D: Nonlinear Phenom. 240, 1092 (2011)] to map the fluid equations bijectively to globally regular systems. By comparing the analytical solutions with the results of numerical simulations, we establish that the numerical simulations of the mapped regular systems are far more accurate than the numerical simulations of the original systems, at the same spatial resolution and CPU time. In particular, the numerical integrations of the mapped regular systems produce robust estimates for the growth exponent and singularity time of the main blowup quantity (vorticity stretching rate), converging well to the analytically-predicted values even beyond the time at which the flow becomes under-resolved (i.e. the reliability time). In contrast, direct numerical integrations of the original systems develop unstable oscillations near the reliability time. We discuss the reasons for this improvement in accuracy, and explain how to extend the analysis to the full 3D case. Supported under the programme for Research in Third Level Institutions (PRTLI) Cycle 5 and co-funded by the European Regional Development Fund.

  11. Blood flow and permeability in microvessels

    NASA Astrophysics Data System (ADS)

    Sugihara-Seki, Masako; Fu, Bingmei M.

    2005-07-01

    The mechanics of blood flow in microvessels and microvessel permeability are reviewed. In the first part, characteristics of blood flow in vivo and in vitro are described from a fluid-mechanical point of view, and mathematical models for blood flow in microvessels are presented. Possible causes of the increased flow resistance obtained in vivo compared to in vitro are examined, including the effects of irregularities of vessel lumen, the presence of endothelial surface glycocalyx and white blood cells. In the second part, the ultrastructural pathways and mechanisms whereby endothelial cells and the clefts between the cells modulate microvessel permeability to water and solutes are introduced. Previous and current models for microvessel permeability to water and solutes are reviewed. These models examine the role of structural components of interendothelial cleft, such as junction strands and surface glycocalyx, in the determination of water and solute transport across the microvessel walls. Transport models in the tissue space surrounding the microvessel are also described.

  12. Age and gender related differences in aortic blood flow

    NASA Astrophysics Data System (ADS)

    Enevoldsen, Marie Sand; Pedersen, Mads Møller; Hemmsen, Martin Christian; Lönn, Lars; Henneberg, Kaj-Åge; Jensen, Jørgen Arendt

    2012-03-01

    The abdominal aorta (AA) is predisposed to development of abdominal aneurysms (AAA), a focal dilatation with fatal consequences if left untreated. The blood flow patterns is thought to play an important role in the development of AAA. The purpose of this work is to investigate the blood flow patterns within a group of healthy volunteers (six females, eight males) aged 23 to 76 years to identify changes and differences related to age and gender. The healthy volunteers were categorized by gender (male/female) and age (below/above 35 years). Subject-specific flow and geometry data were acquired using the research interface on a Profocus ultrasound scanner (B-K Medical, Herlev, Denmark; segmentation of 3D magnetic resonance angiography (Magnetom Trio, Siemens Healthcare, Erlangen, Germany). The largest average diameter was among the elderly males (19.7 (+/- 1.33) mm) and smallest among the young females (12.4 (+/- 0.605) mm). The highest peak systolic velocity was in the young female group (1.02 (+/- 0.336) m/s) and lowest in the elderly male group (0.836 (+/- 0.127) m/s). A geometrical change with age was observed as the AA becomes more bended with age. This also affects the blood flow velocity patterns, which are markedly different from young to elderly. Thus, changes in blood flow patterns in the AA related to age and gender are observed. Further investigations are needed to determine the relation between changes in blood flow patterns and AAA development.

  13. Droplet fragmentation: 3D imaging of a previously unidentified pore-scale process during multiphase flow in porous media

    PubMed Central

    Pak, Tannaz; Butler, Ian B.; Geiger, Sebastian; van Dijke, Marinus I. J.; Sorbie, Ken S.

    2015-01-01

    Using X-ray computed microtomography, we have visualized and quantified the in situ structure of a trapped nonwetting phase (oil) in a highly heterogeneous carbonate rock after injecting a wetting phase (brine) at low and high capillary numbers. We imaged the process of capillary desaturation in 3D and demonstrated its impacts on the trapped nonwetting phase cluster size distribution. We have identified a previously unidentified pore-scale event during capillary desaturation. This pore-scale event, described as droplet fragmentation of the nonwetting phase, occurs in larger pores. It increases volumetric production of the nonwetting phase after capillary trapping and enlarges the fluid−fluid interface, which can enhance mass transfer between the phases. Droplet fragmentation therefore has implications for a range of multiphase flow processes in natural and engineered porous media with complex heterogeneous pore spaces. PMID:25646491

  14. Pancreatic blood flow in experimental acute pancreatitis

    SciTech Connect

    Berry, A.R.; Millar, A.M.; Taylor, T.V.

    1982-05-01

    The etiology and pathogenesis of acute necrotizing hemorrhagic pancreatitis remain controversial. Recent work has suggested that an early fall in pancreatic blood flow, causing ischemia, may be the initiating factor. Using an established rat model of hemorrhagic pancreatitis and the fractional indicator distribution technique with /sup 86/RbCl, pancreatic blood flow and tissue perfusion have been measured at various times in the condition. Six groups of ten rats were studied: control sham operation and pancreatitis groups were sacrificed at 1, 6, and 24 hr. Pancreatic blood flow (% of cardiac output) and perfusion (blood flow/g tissue) were measured. Blood flow was increased by a maximum of 53% at 1 hr (P less than 0.001) and remained elevated for 24 hr, and perfusion was increased by a maximum of 70% (P less than 0.001) at 1 hr and remained elevated at 6 hr. Pancreatic perfusion declines after 6 hr due to increasing gland edema. The results demonstrate a significant increase in pancreatic blood flow and perfusion in experimentally induced acute pancreatitis, suggesting a primary inflammatory response, and refute the ischemic etiological theory.

  15. Simulating Ice-Flow and Calving on Store Glacier, West Greenland, with a 3D Full Stokes Model

    NASA Astrophysics Data System (ADS)

    Todd, J.; Christoffersen, P.; Zwinger, T.; Luckman, A. J.; Benn, D.

    2015-12-01

    The mass balance and long-term stability of the ice sheets in Greenland and Antarctica depend heavily on the dynamics of their ice-ocean margins. Iceberg calving accounts for the majority of the net annual loss of ice in Antarctica and around half of that from Greenland. Furthermore, climate driven changes to dynamics at these calving margins can be transmitted far inland. Thus, predicting future sea level contribution from the cryosphere requires an improved understanding of calving, and the processes which link it to climate and ice-sheet flow. We present results from a new 3D calving model coupled to a full-Stokes, time evolving glacier dynamic model, implemented for Store Glacier, a 5-km-wide calving glacier in the Uummannaq region of West Greenland, which flows at a rate of 20 m/day at its terminus. The model is developed using the open source finite element package Elmer/Ice, with the criterion that calving occurs when surface and basal crevasses meet. Crevasses open in response to tensile stresses near the terminus and water pressure at the bed. When the model was applied in 2D for the central flowline of Store Glacier, we found that basal topography exerts overarching control on the long term position of the calving front, while ice mélange buttressing allows the seasonal extension of a floating tongue, which collapses in early summer. New results emerging from implementation of calving in a 3D model indicate significant spatial heterogeneity in calving dynamics because the northern half of the terminus is grounded whereas the southern half is floating. This contrasting setting affects calving dynamics, further underlining the importance of geometry and basal topography, and suggesting that lower dimensional calving models may miss important aspects of calving dynamics. Our results also suggest that implementing grounding line dynamics is important for modelling calving, even for glaciers which are, for the most part, firmly grounded.

  16. A full 3D model of fluid flow and heat transfer in an E.B. heated liquid metal bath

    NASA Astrophysics Data System (ADS)

    Matveichev, A.; Jardy, A.; Bellot, J. P.

    2016-07-01

    In order to study the dissolution of exogeneous inclusions in the liquid metal during processing of titanium alloys, a series of dipping experiments has been performed in an Electron Beam Melting laboratory furnace. Precise determination of the dissolution kinetics requires knowing and mastering the exact thermohydrodynamic behavior of the melt pool, which implies full 3D modeling of the process. To achieve this goal, one needs to describe momentum and heat transfer, phase change, as well as the development of flow turbulence in the liquid. EB power input, thermal radiation, heat loss through the cooling circuit, surface tension effects (i.e. Marangoni-induced flow) must also be addressed in the model. Therefore a new solver dealing with all these phenomena was implemented within OpenFOAM platform. Numerical results were compared with experimental data from actual Ti melting, showing a pretty good agreement. In the second stage, the immersion of a refractory sample rod in the liquid pool was simulated. Results of the simulations showed that the introduction of the sample slightly disturbs the flow field inside the bath. The amount of such disturbance depends on the exact location of the dipping.

  17. Experimental Investigation of 3-D flow fields around the mouth of the Dwarf Seahorse during attacks on planktonic prey

    NASA Astrophysics Data System (ADS)

    Gemmell, Brad; Buskey, Edward; Sheng, Jian

    2009-11-01

    Copepods are an important planktonic food source for fish species. High predation has led to the development of effective escape responses with short reaction times (less than 2 ms), maximum escape velocities of over 500 body lengths per second and shear sensitivity as low as 1.5s-1. Using high speed digital holography (2 kfps), we measure 3-D distributions of velocity generated by a dwarf seahorse (Hippocampus zosterae) during attacks on its copepod prey, Acartia tonsa. It is found that successful attacks often produce smaller or even no detectable hydrodynamic disturbances around the strike zone, when compared to unsuccessful attempts. In this paper, we will provide quantitative characterization of this ``low-flow'' zone. Further, to elucidate the role of a possible geometrical advantage of the seahorse's head in minimizing its bow wave, high-speed time resolved PIV measurements are conducted in a low-speed water tunnel. On-going analysis will provide insights and implications in understanding the dynamics of flows around the stagnation point at high Reynolds number flow. Sponsored by NSF.

  18. RELAP5-3D Analysis of Pressure Perturbation at the Peach Bottom BWR During Low-Flow Stability Tests

    SciTech Connect

    Lombardi Costa, Antonella; Petruzzi, Alessandro; D'Auria, Francesco

    2006-07-01

    Experimental and theoretical studies about the BWR (Boiling Water Reactor) stability have been performed to design a stable core configuration. BWR instabilities can be caused by inter-dependencies between thermal-hydraulic and reactivity feedback parameters such as the void-coefficient, for example, during a pressure perturbation event. In the present work, the pressure perturbation is considered in order to study in detail this type of transient. To simulate this event, including the strong feedback effects between core neutronic and reactor thermal-hydraulics, and to verify core behavior and evaluate parameters related to safety, RELAP5-3D code has been used in the analyses. The simulation was performed making use of Peach Bottom-2 BWR data to predict the dynamics of a real reactor during this type of event. Stability tests were conducted in the Peach Bottom 2 BWR, in 1977, and were done along the low-flow end of the rated power-flow line, and along the power-flow line corresponding to minimum recirculation pump speed. The calculated results are herein compared against the available experimental data. (authors)

  19. 3D Ultrafast Ultrasound Imaging In Vivo

    PubMed Central

    Provost, Jean; Papadacci, Clement; Arango, Juan Esteban; Imbault, Marion; Gennisson, Jean-Luc; Tanter, Mickael; Pernot, Mathieu

    2014-01-01

    Very high frame rate ultrasound imaging has recently allowed for the extension of the applications of echography to new fields of study such as the functional imaging of the brain, cardiac electrophysiology, and the quantitative real-time imaging of the intrinsic mechanical properties of tumors, to name a few, non-invasively and in real time. In this study, we present the first implementation of Ultrafast Ultrasound Imaging in three dimensions based on the use of either diverging or plane waves emanating from a sparse virtual array located behind the probe. It achieves high contrast and resolution while maintaining imaging rates of thousands of volumes per second. A customized portable ultrasound system was developed to sample 1024 independent channels and to drive a 32×32 matrix-array probe. Its capability to track in 3D transient phenomena occurring in the millisecond range within a single ultrafast acquisition was demonstrated for 3-D Shear-Wave Imaging, 3-D Ultrafast Doppler Imaging and finally 3D Ultrafast combined Tissue and Flow Doppler. The propagation of shear waves was tracked in a phantom and used to characterize its stiffness. 3-D Ultrafast Doppler was used to obtain 3-D maps of Pulsed Doppler, Color Doppler, and Power Doppler quantities in a single acquisition and revealed, for the first time, the complex 3-D flow patterns occurring in the ventricles of the human heart during an entire cardiac cycle, and the 3-D in vivo interaction of blood flow and wall motion during the pulse wave in the carotid at the bifurcation. This study demonstrates the potential of 3-D Ultrafast Ultrasound Imaging for the 3-D real-time mapping of stiffness, tissue motion, and flow in humans in vivo and promises new clinical applications of ultrasound with reduced intra- and inter-observer variability. PMID:25207828

  20. 21 CFR 870.2120 - Extravascular blood flow probe.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Extravascular blood flow probe. 870.2120 Section... blood flow probe. (a) Identification. An extravascular blood flow probe is an extravascular ultrasonic or electromagnetic probe used in conjunction with a blood flowmeter to measure blood flow in...

  1. 21 CFR 870.2120 - Extravascular blood flow probe.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Extravascular blood flow probe. 870.2120 Section... blood flow probe. (a) Identification. An extravascular blood flow probe is an extravascular ultrasonic or electromagnetic probe used in conjunction with a blood flowmeter to measure blood flow in...

  2. 21 CFR 870.2120 - Extravascular blood flow probe.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Extravascular blood flow probe. 870.2120 Section... blood flow probe. (a) Identification. An extravascular blood flow probe is an extravascular ultrasonic or electromagnetic probe used in conjunction with a blood flowmeter to measure blood flow in...

  3. 21 CFR 870.2120 - Extravascular blood flow probe.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Extravascular blood flow probe. 870.2120 Section... blood flow probe. (a) Identification. An extravascular blood flow probe is an extravascular ultrasonic or electromagnetic probe used in conjunction with a blood flowmeter to measure blood flow in...

  4. Modeling Blood Flow in the Aorta.

    ERIC Educational Resources Information Center

    McConnell, Colin J.; Carmichael, Jonathan B.; DeMont, M. Edwin

    1997-01-01

    Presents an exercise to demonstrate two fundamental concepts of fluid mechanics: the Reynolds number and the Principle of Continuity. The exercise demonstrates flow in a major blood vessel, such as the aorta, with and without a stenosis. Students observe the transition from laminar to turbulent flow as well as downstream persistence of turbulence.…

  5. A New Approach to Sap Flow Measurement Using 3D Printed Gauges and Open-source Electronics

    NASA Astrophysics Data System (ADS)

    Ham, J. M.; Miner, G. L.; Kluitenberg, G. J.

    2015-12-01

    A new type of sap flow gauge was developed to measure transpiration from herbaceous plants using a modified heat pulse technique. Gauges were fabricated using 3D-printing technology and low-cost electronics to keep the materials cost under $20 (U.S.) per sensor. Each gauge consisted of small-diameter needle probes fastened to a 3D-printed frame. One needle contained a resistance heater to provide a 6 to 8 second heat pulse while the other probes measured the resultant temperature increase at two distances from the heat source. The data acquisition system for the gauges was built from a low-cost Arduino microcontroller. The system read the gauges every 10 minutes and stored the results on a SD card. Different numerical techniques were evaluated for estimating sap velocity from the heat pulse data - including analytical solutions and parameter estimation approaches . Prototype gauges were tested in the greenhouse on containerized corn and sunflower. Sap velocities measured by the gauges were compared to independent gravimetric measurements of whole plant transpiration. Results showed the system could measure daily transpiration to within 3% of the gravimetric measurements. Excellent agreement was observed when two gauges were attached the same stem. Accuracy was not affected by rapidly changing transpiration rates observed under partly cloudy conditions. The gauge-based estimates of stem thermal properties suggested the system may also detect the onset of water stress. A field study showed the gauges could run for 1 to 2 weeks on a small battery pack. Sap flow measurements on multiple corn stems were scaled up by population to estimate field-scale transpiration. During full canopy cover, excellent agreement was observed between the scaled-up sap flow measurements and reference crop evapotranspiration calculated from weather data. Data also showed promise as a way to estimate real-time canopy resistance required for model verification and development. Given the low

  6. Correlation between lack of norovirus replication and histo-blood group antigen expression in 3D-intestinal epithelial cultures

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Noroviruses (NoV) are a leading cause of gastroenteritis worldwide. An in vitro model for NoV replication remains elusive, making study of the virus difficult. One publication utilizing a 3-dimensional (3D) intestinal model derived from Int407 cells reported NoV replication and extensive cytopathi...

  7. Multigrid mapping and box relaxation for simulation of the whole process of flow transition in 3-D boundary layers

    SciTech Connect

    Liu, C.; Liu, Z.

    1994-12-31

    A new multilevel technology was developed in this study which provides a successful numerical simulation for the whole process of flow transition in 3-D flat plate boundary layers, including linear growth, secondary instability, breakdown, and transition on a relatively coarse grid with low CPU cost. A fourth-order finite difference scheme on stretched and staggered grids, a fully implicit time-marching technique, a semi-coarsening multigrid based on the so-called approximate line-box relaxation, and a buffer domain for the outflow boundary conditions were all employed for high-order accuracy, good stability, and fast convergence. A new fine-coarse-fine grid mapping technique was developed to catch the large eddies and represent main roles of small eddies to keep the code running after the laminar flow breaks down. The computational results are in good agreement with linear stability theory, secondary instability theory, and some experiments. The computation also reproduced the K-type and C-type transition observed by laboratory experiments. The CPU cost for a typical case is around 2-9 CRAY-YMP hours.

  8. A 3D-CFD code for accurate prediction of fluid flows and fluid forces in seals

    NASA Technical Reports Server (NTRS)

    Athavale, M. M.; Przekwas, A. J.; Hendricks, R. C.

    1994-01-01

    Current and future turbomachinery requires advanced seal configurations to control leakage, inhibit mixing of incompatible fluids and to control the rotodynamic response. In recognition of a deficiency in the existing predictive methodology for seals, a seven year effort was established in 1990 by NASA's Office of Aeronautics Exploration and Technology, under the Earth-to-Orbit Propulsion program, to develop validated Computational Fluid Dynamics (CFD) concepts, codes and analyses for seals. The effort will provide NASA and the U.S. Aerospace Industry with advanced CFD scientific codes and industrial codes for analyzing and designing turbomachinery seals. An advanced 3D CFD cylindrical seal code has been developed, incorporating state-of-the-art computational methodology for flow analysis in straight, tapered and stepped seals. Relevant computational features of the code include: stationary/rotating coordinates, cylindrical and general Body Fitted Coordinates (BFC) systems, high order differencing schemes, colocated variable arrangement, advanced turbulence models, incompressible/compressible flows, and moving grids. This paper presents the current status of code development, code demonstration for predicting rotordynamic coefficients, numerical parametric study of entrance loss coefficients for generic annular seals, and plans for code extensions to labyrinth, damping, and other seal configurations.

  9. Impact of integrated 3D reservoir modeling/flow simulation on development of deepwater sands, Mars Field, Gulf of Mexico

    SciTech Connect

    Lerch, C.S.; Johnston, J.R.; Juedeman, M.E.

    1996-12-31

    Prospect Mars is a major Gulf of Mexico deep water oil discovery made under joint partnership between operator Shell Offshore Inc. and partner British Petroleum Inc. The discovery lies in 3000 feet of water, located 130 miles southeast of New Orleans, Louisiana. The field was discovered in 1989 and to date 14 significant reservoir intervals from 10,000 to 19000 feet below sea level have been penetrated. Estimated recoverable reserves for the first phase of field development are in excess of 500 MMBE and development plans include installation of a 24 slot tension leg platform and two subsea wells, with first production in mid-1996. Over a two year period a comprehensive effort was directed at creating a new set of reservoir models utilizing an integrated software package developed at Shell E&P Technology Co. This package is able to incorporate pertinent geological, geophysical, and petrophysical data into 3-D reservoir models which can be used to: (1) estimate reservoir quantity, quality, and continuity, (2) predict reservoir production performance, (3) select development well locations, and (4) facilitate reserve estimation. This software allows interpretations from 3-D seismic, well control, and analog outcrops to be effectively integrated and passed to the reservoir model for flow simulation. This integrated effort at modeling ensured a more realistic reservoir picture upon which to base field development. Almost all the development wells pre-drilled prior to platform installation have been affected or designed based on these reservoir models and well results have been used to keep the models updated and evergreen.

  10. In vivo determination of bone blood flow

    SciTech Connect

    Rosenthal, M.S.; De Luca, P.M. Jr.; Pearson, D.W.; Nickles, R.J.

    1984-01-01

    Quantitative measurement of bone blood flow is vital to understand the hemodynamics of bone systems especially in the study of asceptic bone necroses. These ''silent bends'' result from micro-emboli in femoral arterioles from small nitrogen bubbles released from lipids during a diver's ascent. A technique to determine bone blood flow in vivo has been developed by measuring the rate of inert gas washout of Ar-41 (t /sub 1/2/ = 1.83 h, E = 1293 keV) from the bone mineral matrix. Argon gas is formed in vivo by neutron activation of Ca-44 using 14.3 MeV neutrons, following the reaction Ca-44(n, ..cap alpha..)Ar-41. The blood flow in the irradiated bone is determined by measuring the clearance rate of Ar-41 using gamma-ray spectroscopy. To date, measurements have been made on dead and living rats (weight 300g). The results indicated that in the no-flow situation the clearance rate is consistent with the physical half-life of Ar-41, while for the live rats the clearance rate for argon is dependent on the flow of blood in the bone. The observed clearance times correspond to flows greater than 3 ml of blood per 100 ml of argon distribution volume/min (F/pV), with the bone-blood partition coefficient for argon approximately one. In addition, measurements of the partitioning of argon and other gases with bone have been measured in order to understand blood-bone systems more fully.

  11. Flow above and within granular media composed of spherical and non-spherical particles - using a 3D numerical model

    NASA Astrophysics Data System (ADS)

    Bartzke, Gerhard; Kuhlmann, Jannis; Huhn, Katrin

    2016-04-01

    The entrainment of single grains and, hence, their erosion characteristics are dependent on fluid forcing, grain size and density, but also shape variations. To quantitatively describe and capture the hydrodynamic conditions around individual grains, researchers commonly use empirical approaches such as laboratory flume tanks. Nonetheless, it is difficult with such physical experiments to measure the flow velocities in the direct vicinity or within the pore spaces of sediments, at a sufficient resolution and in a non-invasive way. As a result, the hydrodynamic conditions in the water column, at the fluid-porous interface and within pore spaces of a granular medium of various grain shapes is not yet fully understood. For that reason, there is a strong need for numerical models, since these are capable of quantifying fluid speeds within a granular medium. A 3D-SPH (Smooth Particle Hydrodynamics) numerical wave tank model was set up to provide quantitative evidence on the flow velocities in the direct vicinity and in the interior of granular beds composed of two shapes as a complementary method to the difficult task of in situ measurement. On the basis of previous successful numerical wave tank models with SPH, the model geometry was chosen in dimensions of X=2.68 [m], Y=0.48 [m], and Z=0.8 [m]. Three suites of experiments were designed with a range of particle shape models: (1) ellipsoids with the long axis oriented in the across-stream direction, (2) ellipsoids with the long axis oriented in the along-stream direction, and (3) spheres. Particle diameters ranged from 0.04 [m] to 0.08 [m]. A wave was introduced by a vertical paddle that accelerated to 0.8 [m/s] perpendicular to the granular bed. Flow measurements showed that the flow velocity values into the beds were highest when the grains were oriented across the stream direction and lowest in case when the grains were oriented parallel to the stream, indicating that the model was capable to simulate simultaneously

  12. An implantable blood pressure and flow transmitter.

    NASA Technical Reports Server (NTRS)

    Rader, R. D.; Meehan, J. P.; Henriksen, J. K. C.

    1973-01-01

    A miniature totally implantable FM/FM telemetry system has been developed to simultaneously measure blood pressure and blood flow, thus providing an appreciation of the hemodynamics of the circulation to the entire body or to a particular organ. Developed for work with animal subjects, the telemetry system's transmission time is controlled by an RF signal that permits an operating life of several months. Pressure is detected by a miniature intravascular transducer and flow is detected by an extravascular interferometric ultrasonic technique. Both pressure and flow are calibrated prior to implanting. The pressure calibration can be checked after the implanting by cannulation; flow calibration can be verified only at the end of the experiment by determining the voltage output from the implanted sensing system as a function of several measured flow rates. The utility of this device has been established by its use in investigating canine renal circulation during exercise, emotional encounters, administration of drugs, and application of accelerative forces.

  13. Multi-scale simulation flow and multi-scale materials characterization for stress management in 3D through-silicon-via integration technologies - Effect of stress on 3D IC interconnect reliability

    NASA Astrophysics Data System (ADS)

    Sukharev, Valeriy; Zschech, Ehrenfried

    2014-06-01

    The paper addresses the growing need in a simulation-based design verification flow capable to analyze any design of 3D IC stacks and to determine across-layers implications in 3D IC reliability caused by through-silicon-via (TSV) and chip-package interaction (CPI) induced mechanical stresses. The limited characterization/measurement capabilities of 3D IC stacks and a strict "good die" requirement make this type of analysis really critical for the achievement of an acceptable level of functional and parametric yield and reliability. The paper focuses on the development of a design-for-manufacturability (DFM) type of methodology for managing mechanical stresses during a sequence of designs of 3D TSV-based dies, stacks and packages. A set of physics-based compact models for a multi-scale simulation, to assess the mechanical stress across the dies stacked and packaged with the 3D TSV technology, is proposed. As an example the effect of CPI/TSV induced stresses on stress migration (SM) and electromigration (EM) in the back-end-of-line (BEoL) and backside-redistribution-layer (BRDL) interconnect lines is considered. A strategy for a simulation feeding data generation and a respective materials characterization approach are proposed, with the goal to generate a database for multi-scale material parameters of wafer-level and package-level structures. A calibration technique based on fitting the simulation results to measured stress components and electrical characteristics of the test-chip devices is discussed.

  14. Modeling GPR data to interpret porosity and DNAPL saturations for calibration of a 3-D multiphase flow simulation

    USGS Publications Warehouse

    Sneddon, Kristen W.; Powers, Michael H.; Johnson, Raymond H.; Poeter, Eileen P.

    2002-01-01

    Dense nonaqueous phase liquids (DNAPLs) are a pervasive and persistent category of groundwater contamination. In an effort to better understand their unique subsurface behavior, a controlled and carefully monitored injection of PCE (perchloroethylene), a typical DNAPL, was performed in conjunction with the University of Waterloo at Canadian Forces Base Borden in 1991. Of the various geophysical methods used to monitor the migration of injected PCE, the U.S. Geological Survey collected 500-MHz ground penetrating radar (GPR) data. These data are used in determining calibration parameters for a multiphase flow simulation. GPR data were acquired over time on a fixed two-dimensional surficial grid as the DNAPL was injected into the subsurface. Emphasis is on the method of determining DNAPL saturation values from this time-lapse GPR data set. Interactive full-waveform GPR modeling of regularized field traces resolves relative dielectric permittivity versus depth profiles for pre-injection and later-time data. Modeled values are end members in recursive calculations of the Bruggeman-Hanai-Sen (BHS) mixing formula, yielding interpreted pre-injection porosity and post-injection DNAPL saturation values. The resulting interpreted physical properties of porosity and DNAPL saturation of the Borden test cell, defined on a grid spacing of 50 cm with 1-cm depth resolution, are used as observations for calibration of a 3-D multiphase flow simulation. Calculated values of DNAPL saturation in the subsurface at 14 and 22 hours after the start of injection, from both the GPR and the multiphase flow modeling, are interpolated volumetrically and presented for visual comparison.

  15. Direct measurement of particle size and 3D velocity of a gas-solid pipe flow with digital holographic particle tracking velocimetry.

    PubMed

    Wu, Yingchun; Wu, Xuecheng; Yao, Longchao; Gréhan, Gérard; Cen, Kefa

    2015-03-20

    The 3D measurement of the particles in a gas-solid pipe flow is of great interest, but remains challenging due to curved pipe walls in various engineering applications. Because of the astigmatism induced by the pipe, concentric ellipse fringes in the hologram of spherical particles are observed in the experiments. With a theoretical analysis of the particle holography by an ABCD matrix, the in-focus particle image can be reconstructed by the modified convolution method and fractional Fourier transform. Thereafter, the particle size, 3D position, and velocity are simultaneously measured by digital holographic particle tracking velocimetry (DHPTV). The successful application of DHPTV to the particle size and 3D velocity measurement in a glass pipe's flow can facilitate its 3D diagnostics.

  16. Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner

    NASA Technical Reports Server (NTRS)

    Bancroft, Gregory N.; Sikavitsas, Vassilios I.; van den Dolder, Juliette; Sheffield, Tiffany L.; Ambrose, Catherine G.; Jansen, John A.; Mikos, Antonios G.; McIntire, L. V. (Principal Investigator)

    2002-01-01

    Bone is a complex highly structured mechanically active 3D tissue composed of cellular and matrix elements. The true biological environment of a bone cell is thus derived from a dynamic interaction between responsively active cells experiencing mechanical forces and a continuously changing 3D matrix architecture. To investigate this phenomenon in vitro, marrow stromal osteoblasts were cultured on 3D scaffolds under flow perfusion with different rates of flow for an extended period to permit osteoblast differentiation and significant matrix production and mineralization. With all flow conditions, mineralized matrix production was dramatically increased over statically cultured constructs with the total calcium content of the cultured scaffolds increasing with increasing flow rate. Flow perfusion induced de novo tissue modeling with the formation of pore-like structures in the scaffolds and enhanced the distribution of cells and matrix throughout the scaffolds. These results represent reporting of the long-term effects of fluid flow on primary differentiating osteoblasts and indicate that fluid flow has far-reaching effects on osteoblast differentiation and phenotypic expression in vitro. Flow perfusion culture permits the generation and study of a 3D, actively modeled, mineralized matrix and can therefore be a valuable tool for both bone biology and tissue engineering.

  17. Controls on hydrothermal fluid flow within the Rotokawa geothermal field, New Zealand: insights from 3D geological models

    NASA Astrophysics Data System (ADS)

    Bardsley, C.; Sewell, S.; Cumming, W. B.; Minnick, M.; Rowland, J. V.; O'Brien, J.; Price, L.

    2012-12-01

    Identifying permeable zones is essential for economically viable exploration and development of conventional geothermal reservoirs with naturally high permeability. Except very close to boreholes, the resolution of geological and geophysical tools is at a much larger scale than the centimetre aperture of most geothermal fluid pathways important to production. A case study from the >250°C Rotokawa Geothermal Field, currently producing 175 MWe within the Taupo Volcanic Zone in New Zealand, illustrates how a 3D visualization of a subset of available data that are conceptually relevant at the scales of interest has enhanced the understanding of fluid flow within this system. Geoscience data sets including subsurface formation geometry and permeable zones in wells; the natural state temperature pattern deduced from wells and MT resistivity; microearthquakes (MEQ) induced by injection, and surface geology have been integrated with engineering data including production pressure responses and injection rates to constrain the location and general hydraulic properties of one of the most influential faults in the field. Stratigraphic offsets of >500 m, recorded in core and cuttings from wells drilled on either side of the field, confirm the presence of this fault, initially suspected based on a surface lineation of eight young (<22 ka) hydrothermal eruption craters. The 3D visualization of the MEQ occurrence pattern in space and time helps constrain the mechanism of the MEQs themselves and, importantly, the confinement of most of the MEQs to the eastern side of the fault closest to the injection wells. Hosted within the Mesozoic meta-sedimentary basement formation, this has provided an important conceptual constraint that explains the lack of injection fluid on the western side of this fault. Further to this, if this fault is acting as a barrier at the Mesozoic meta-sedimentary level today, this could imply a switch in the behaviour of this structure as it is inferred, based

  18. Flow-through polymerase chain reaction inside a seamless 3D helical microreactor fabricated utilizing a silicone tube and a paraffin mold.

    PubMed

    Wu, Wenming; Trinh, Kieu The Loan; Lee, Nae Yoon

    2015-03-01

    We introduce a new strategy for fabricating a seamless three-dimensional (3D) helical microreactor utilizing a silicone tube and a paraffin mold. With this method, various shapes and sizes of 3D helical microreactors were fabricated, and a complicated and laborious photolithographic process, or 3D printing, was eliminated. With dramatically enhanced portability at a significantly reduced fabrication cost, such a device can be considered to be the simplest microreactor, developed to date, for performing the flow-through polymerase chain reaction (PCR).

  19. Luteal blood flow and luteal function

    PubMed Central

    Takasaki, Akihisa; Tamura, Hiroshi; Taniguchi, Ken; Asada, Hiromi; Taketani, Toshiaki; Matsuoka, Aki; Yamagata, Yoshiaki; Shimamura, Katsunori; Morioka, Hitoshi; Sugino, Norihiro

    2009-01-01

    Background Blood flow in the corpus luteum (CL) is associated with luteal function. The present study was undertaken to investigate whether luteal function can be improved by increasing CL blood flow in women with luteal phase defect (LFD). Methods Blood flow impedance in the CL was measured by transvaginal color-pulsed-Doppler-ultrasonography and was expressed as a resistance index (RI). The patients with both LFD [serum progesterone (P) concentrations < 10 ng/ml during mid-luteal phase] and high CL-RI (≥ 0.51) were given vitamin-E (600 mg/day, n = 18), L-arginine (6 g/day, n = 14) as a potential nitric oxide donor, melatonin (3 mg/day, n = 13) as an antioxidant, or HCG (2,000 IU/day, n = 10) during the subsequent menstrual cycle. Results In the control group (n = 11), who received no medication to increase CL blood flow, only one patient (9%) improved in CL-RI and 2 patients (18%) improved in serum P. Vitamin-E improved CL-RI in 15 patients (83%) and improved serum P in 12 patients (67%). L-arginine improved CL-RI in all the patients (100%) and improved serum P in 10 patients (71%). HCG improved CL-RI in all the patients (100%) and improved serum P in 9 patients (90%). Melatonin had no significant effect. Conclusion Vitamin-E or L-arginine treatment improved luteal function by decreasing CL blood flow impedance. CL blood flow is a critical factor for luteal function. PMID:19144154

  20. The Role of Neuronal Signaling in Controlling Cerebral Blood Flow

    ERIC Educational Resources Information Center

    Drake, Carrie T.; Iadecola, Costantino

    2007-01-01

    Well-regulated blood flow within the brain is vital to normal function. The brain's requirement for sufficient blood flow is ensured by a tight link between neural activity and blood flow. The link between regional synaptic activity and regional cerebral blood flow, termed functional hyperemia, is the basis for several modern imaging techniques…

  1. Blood flow characteristics in the aortic arch

    NASA Astrophysics Data System (ADS)

    Prahl Wittberg, Lisa; van Wyk, Stevin; Mihaiescu, Mihai; Fuchs, Laszlo; Gutmark, Ephraim; Backeljauw, Philippe; Gutmark-Little, Iris

    2012-11-01

    The purpose with this study is to investigate the flow characteristics of blood in the aortic arch. Cardiovascular diseases are associated with specific locations in the arterial tree. Considering atherogenesis, it is claimed that the Wall Shear Stress (WSS) along with its temporal and spatial gradients play an important role in the development of the disease. The WSS is determined by the local flow characteristics, that in turn depends on the geometry as well as the rheological properties of blood. In this numerical work, the time dependent fluid flow during the entire cardiac cycle is fully resolved. The Quemada model is applied to account for the non-Newtonian properties of blood, an empirical model valid for different Red Blood Cell loading. Data obtained through Cardiac Magnetic Resonance Imaging have been used in order to reconstruct geometries of the the aortic arch. Here, three different geometries are studied out of which two display malformations that can be found in patients having the genetic disorder Turner's syndrome. The simulations show a highly complex flow with regions of secondary flow that is enhanced for the diseased aortas. The financial support from the Swedish Research Council (VR) and the Sweden-America Foundation is gratefully acknowledged.

  2. Numerical model of water flow and solute accumulation in vertisols using HYDRUS 2D/3D code

    NASA Astrophysics Data System (ADS)

    Weiss, Tomáš; Dahan, Ofer; Turkeltub, Tuvia

    2015-04-01

    Keywords: dessication-crack-induced-salinization, preferential flow, conceptual model, numerical model, vadose zone, vertisols, soil water retention function, HYDRUS 2D/3D Vertisols cover a hydrologically very significant area of semi-arid regions often through which water infiltrates to groundwater aquifers. Understanding of water flow and solute accumulation is thus very relevant to agricultural activity and water resources management. Previous works suggest a conceptual model of dessication-crack-induced-salinization where salinization of sediment in the deep section of the vadose zone (up to 4 m) is induced by subsurface evaporation due to convective air flow in the dessication cracks. It suggests that the salinization is induced by the hydraulic gradient between the dry sediment in the vicinity of cracks (low potential) and the relatively wet sediment further from the main cracks (high potential). This paper presents a modified previously suggested conceptual model and a numerical model. The model uses a simple uniform flow approach but unconventionally prescribes the boundary conditions and the hydraulic parameters of soil. The numerical model is bound to one location close to a dairy farm waste lagoon, but the application of the suggested conceptual model could be possibly extended to all semi-arid regions with vertisols. Simulations were conducted using several modeling approaches with an ultimate goal of fitting the simulation results to the controlling variables measured in the field: temporal variation in water content across thick layer of unsaturated clay sediment (>10 m), sediment salinity and salinity the water draining down the vadose zone to the water table. The development of the model was engineered in several steps; all computed as forward solutions by try-and-error approach. The model suggests very deep instant infiltration of fresh water up to 12 m, which is also supported by the field data. The paper suggests prescribing a special atmospheric

  3. 3D crustal-scale heat-flow regimes at a developing active margin (Taranaki Basin, New Zealand)

    NASA Astrophysics Data System (ADS)

    Kroeger, K. F.; Funnell, R. H.; Nicol, A.; Fohrmann, M.; Bland, K. J.; King, P. R.

    2013-04-01

    The Taranaki Basin in the west of New Zealand's North Island has evolved from a rifted Mesozoic Gondwana margin to a basin straddling the Neogene convergent Australian-Pacific plate margin. However, given its proximity to the modern subduction front, Taranaki Basin is surprisingly cold when compared to other convergent margins. To investigate the effects of active margin evolution on the thermal regime of the Taranaki Basin we developed a 3D crustal-scale forward model using the petroleum industry-standard basin-modelling software Petromod™. The crustal structure inherited from Mesozoic Gondwana margin breakup and processes related to modern Hikurangi convergent margin initiation are identified to be the main controls on the thermal regime of the Taranaki Basin. Present-day surface heat flow across Taranaki on average is 59 mW/m2, but varies by as much as 30 mW/m2 due to the difference in crustal heat generation between mafic and felsic basement terranes alone. In addition, changes in mantle heat advection, tectonic subsidence, crustal thickening and basin inversion, together with related sedimentary processes result in variability of up to 10 mW/m2. Modelling suggests that increased heating of the upper crust due to additional mantle heat advection following the onset of subduction is an ongoing process and heating has only recently begun to reach the surface, explaining the relatively low surface heat flow. We propose that the depth of the subducted slab and related mantle convection processes control the thermal and structural regimes in the Taranaki Basin. The thermal effects of the subduction initiation process are modified and overprinted by the thickness, structure and composition of the lithosphere.

  4. Bioconjugation of peptides using advanced nanomaterials to examine their interactions in 3D printed flow-through device.

    PubMed

    Michalek, Petr; Richtera, Lukas; Krejcova, Ludmila; Nejdl, Lukas; Kensova, Renata; Zitka, Jan; Kopel, Pavel; Heger, Zbynek; Adam, Vojtech; Kizek, Rene

    2016-02-01

    Peptide-peptide interactions are crucial in the living cell as they lead to the formation of the numerous types of complexes. In this study, synthetic peptides containing 11 of cysteines (α-domain of metallothionein (MT)) and sialic acid binding region (130-loop of hemagglutinin (HA)) were employed. The aim of the experiment was studying the interactions between MT and HA-derived peptides. For this purpose, fragments were tagged with cysteines at C-terminal part to serve as ligand sites for PbS and CuS quantum dots (QDs), and therefore these conjugates can be traced and quantified during wide spectrum of methods. As a platform for interaction, γ-Fe2O3 paramagnetic particles modified with tetraethyl orthosilicate and (3-aminopropyl)triethoxysilane (hydrodynamic diameter 30-40 nm) were utilized and MT/HA interactions were examined using multi-instrumental approach including electrochemistry, electrophoretic methods, and MALDI-TOF/TOF mass spectrometry. It was found that peptides enter mutual creation of complexes, which are based on some of nonbonded interactions. The higher willingness to interact was observed in MT-derived peptides toward immobilized HA. Finally, we designed and manufactured flow-through electrochemical 3D printed device (reservoir volume 150 μL) and utilized it for automated analysis of the HA/MT metal labels. Under the optimal conditions, (deposition time and flow rate 80 s and 1.6 mL/min for CuS and 120 s and 1.6 mL/min PbS, respectively), the results of peptide-conjugated QDs were comparable with atomic absorption spectrometry. PMID:26462605

  5. Chaotic dynamics of red blood cells in oscillating shear flow

    NASA Astrophysics Data System (ADS)

    Bagchi, Prosenjit; Cordasco, Daniel

    2015-11-01

    A 3D computational study of deformable red blood cells in dilute suspension and subject to sinusoidally oscillating shear flow is considered. It is observed that the cell exhibits either a periodic motion or a chaotic motion. In the periodic motion, the cell reverses its orientation either about the flow direction or about the flow gradient, depending on the initial conditions. In certain parameter range, the initial conditions are forgotten and the cells become entrained in the same sequence of horizontal reversals. The chaotic dynamics is characterized by a nonperiodic sequence of horizontal and vertical reversals, and swings. The study provides the first conclusive evidence of the chaotic dynamics of fully deformable cells in oscillating flow using a deterministic numerical model without the introduction of any stochastic noise. An analysis of the chaotic dynamics shows that chaos is only possible in certain frequency bands when the cell membrane can rotate by a certain amount allowing the cells to swing near the maximum shear rate. We make a novel observation that the occurrence of the vertical or horizontal reversal depends only on whether a critical angle, that is independent of the flow frequency, is exceeded at the instant of flow reversal.

  6. Examining rhyolite lava flow dynamics through photo-based 3-D reconstructions of the 2011-2012 lava flow field at Cordón Caulle, Chile.

    NASA Astrophysics Data System (ADS)

    James, M. R.; Farquharson, J.; Tuffen, H.

    2014-12-01

    The 2011-2012 eruption at Cordón-Caulle, Chile, afforded the opportunity to observe and measure active rhyolitic lava for the first time. In 2012 and 2013, ~2500 photos were acquired on foot, parallel to flow fronts on the north and north-east of the flow field. Image suites were then processed into 3-D point clouds using Structure-from-Motion Multi-view Stereo (SfM-MVS) freeware. Interpolating these clouds into digital elevation models for dates in 2012-13 enabled analysis of the changing flow field dimensions [1], from which velocity, depth and rheological parameters, e.g.viscosity, could be estimated [see Fig. 1]. Viscosities ranged from 7.5 x109 to 1.1 x1011Pa s, allowing for uncertainties in slope, surface displacement and velocity. Temperatures were modeled using a 1D finite difference method; in concert with viscosities of flow units these values compared well with published non-Arrhenian viscosity models. Derived thermodynamic and force ratios confirmed flow characteristics inferred from the image analyses. SfM-MVS represents an effective method of quantifying and displaying variation in the flow field, indicating several parallels between rhyolite emplacement and that of low-silica lavas. Initially channelised lava spread laterally and stagnated due to topography and the influence of the surface crust. Continued effusion resulted in iterative emplacement of breakout lobes, promoting lateral extension of the flow field. Insulation of the flow core by the viscous crust allowed this process to continue after effusion had ceased, creating features comparable to low-silica lavas, despite high viscosity and low effusion rates. This suggests that compound flow emplacement may be described by universal, cross-compositional models encompassing rheological differences of many orders of magnitude. Tuffen et al. 2013, Nat. Comms., 4, 2709, doi:10.1038/ncomms3709

  7. Effects of Dorzolamide on Choroidal Blood Flow, Ciliary Blood Flow, and Aqueous Production in Rabbits

    PubMed Central

    Reitsamer, Herbert A.; Bogner, Barbara; Tockner, Birgit; Kiel, Jeffrey W.

    2015-01-01

    Purpose To determine the effects of topical dorzolamide (a carbonic anhydrase inhibitor) on choroidal and ciliary blood flow and the relationship between ciliary blood flow and aqueous flow. Methods The experiments were performed in four groups of pentobarbital-anesthetized rabbits treated with topical dorzolamide (2%, 50 μL). In all groups, intraocular pressure (IOP) and mean arterial pressure (MAP) at the eye level were measured continuously by direct cannulation. In group 1, aqueous flow was measured by fluorophotometry before and after dorzolamide treatment. In group 2, aqueous flow was measured after dorzolamide at normal MAP and while MAP was held constant at 80, 55, or 40 mm Hg with occluders on the aorta and vena cava. In group 3, the same MAP levels were used, and ciliary blood flow was measured transsclerally by laser Doppler flowmetry (LDF). In group 4, choroidal blood flow was measured by LDF with the probe tip positioned in the vitreous over the posterior pole during ramp increases and decreases in MAP before and after dorzolamide. Results Dorzolamide lowered IOP by 19% (P < 0.01) and aqueous flow by 17% (P < 0.01), and increased ciliary blood flow by 18% (P < 0.01), which was associated with a significant reduction in ciliary vasculature resistance (−7%, P < 0.01). Dorzolamide shifted the relationship between ciliary blood flow and aqueous flow downward relative to the previously determined control relationship in the rabbit. Dorzolamide did not alter choroidal blood flow, choroidal vascular resistance, or the choroidal pressure flow relationship. Conclusions Acute topical dorzolamide is a ciliary vasodilator and has a direct inhibitory effect on aqueous production, but it does not have a detectable effect on choroidal hemodynamics at the posterior pole in the rabbit. PMID:19182250

  8. Blood flow dynamics in the snake spectacle.

    PubMed

    van Doorn, Kevin; Sivak, Jacob G

    2013-11-15

    The eyes of snakes are shielded beneath a layer of transparent integument referred to as the 'reptilian spectacle'. Well adapted to vision by virtue of its optical transparency, it nevertheless retains one characteristic of the integument that would otherwise prove detrimental to vision: its vascularity. Given the potential consequence of spectacle blood vessels on visual clarity, one might expect adaptations to have evolved that mitigate their negative impact. Earlier research demonstrated an adaptation to their spatial layout in only one species to reduce the vessels' density in the region serving the foveal and binocular visual fields. Here, we present a study of spectacle blood flow dynamics and provide evidence of a mechanism to mitigate the spectacle blood vessels' deleterious effect on vision by regulation of blood flow through them. It was found that when snakes are at rest and undisturbed, spectacle vessels undergo cycles of dilation and constriction, such that the majority of the time the vessels are fully constricted, effectively removing them from the visual field. When snakes are presented with a visual threat, spectacle vessels constrict and remain constricted for longer periods than occur during the resting cycles, thus guaranteeing the best possible visual capabilities in times of need. Finally, during the snakes' renewal phase when they are generating a new stratum corneum, the resting cycle is abolished, spectacle vessels remain dilated and blood flow remains strong and continuous. The significance of these findings in terms of the visual capabilities and physiology of snakes is discussed.

  9. Uncertainty quantification in coronary blood flow simulations: Impact of geometry, boundary conditions and blood viscosity.

    PubMed

    Sankaran, Sethuraman; Kim, Hyun Jin; Choi, Gilwoo; Taylor, Charles A

    2016-08-16

    Computational fluid dynamic methods are currently being used clinically to simulate blood flow and pressure and predict the functional significance of atherosclerotic lesions in patient-specific models of the coronary arteries extracted from noninvasive coronary computed tomography angiography (cCTA) data. One such technology, FFRCT, or noninvasive fractional flow reserve derived from CT data, has demonstrated high diagnostic accuracy as compared to invasively measured fractional flow reserve (FFR) obtained with a pressure wire inserted in the coronary arteries during diagnostic cardiac catheterization. However, uncertainties in modeling as well as measurement results in differences between these predicted and measured hemodynamic indices. Uncertainty in modeling can manifest in two forms - anatomic uncertainty resulting in error of the reconstructed 3D model and physiologic uncertainty resulting in errors in boundary conditions or blood viscosity. We present a data-driven framework for modeling these uncertainties and study their impact on blood flow simulations. The incompressible Navier-Stokes equations are used to model blood flow and an adaptive stochastic collocation method is used to model uncertainty propagation in the Navier-Stokes equations. We perform uncertainty quantification in two geometries, an idealized stenosis model and a patient specific model. We show that uncertainty in minimum lumen diameter (MLD) has the largest impact on hemodynamic simulations, followed by boundary resistance, viscosity and lesion length. We show that near the diagnostic cutoff (FFRCT=0.8), the uncertainty due to the latter three variables are lower than measurement uncertainty, while the uncertainty due to MLD is only slightly higher than measurement uncertainty. We also show that uncertainties are not additive but only slightly higher than the highest single parameter uncertainty. The method presented here can be used to output interval estimates of hemodynamic indices

  10. On the local acceleration and flow trajectory of jet flows from circular and semi-circular pipes via 3D particle tracking velocimetry

    NASA Astrophysics Data System (ADS)

    Kim, Jin-Tae; Liberzon, Alex; Chamorro, Leonardo P.

    2015-11-01

    The distinctive differences between two jet flows that share the same hydraulic diameter dh = 0.01 m and Re ~ 6000, but different (nozzle) shape are explored via 3D Particle Tracking Velocimetry using OpenPTV (http://www.openptv.net). The two jets are formed from circular and semicircular pipes and released in a quiescent water tank of 40 dh height, 40 dh wide, and 200 dh long. The recirculating system is seeded with 100 μm particles, where flow measurements are performed in the intermediate flow field (14.5 < x /dh <18.5) at 550Hz for a total of ~ 30,000 frames. Analysis is focused on the spatial distribution of the local flow acceleration and curvature of the Lagrangian trajectories. The velocity and acceleration of particles are estimated by low-pass filtering their position with a moving cubic spline fitting, while the curvature is obtained from the Frenet-Serret equations. Probability density functions (p.d.f.) of these quantities are obtained at various sub-volumes containing a given streamwise velocity range, and compared between the two cases to evaluate the memory effects in the intermediate flow field.

  11. Rn3D: A finite element code for simulating gas flow and radon transport in variably saturated, nonisothermal porous media. User`s manual, Version 1.0

    SciTech Connect

    Holford, D.J.

    1994-01-01

    This document is a user`s manual for the Rn3D finite element code. Rn3D was developed to simulate gas flow and radon transport in variably saturated, nonisothermal porous media. The Rn3D model is applicable to a wide range of problems involving radon transport in soil because it can simulate either steady-state or transient flow and transport in one-, two- or three-dimensions (including radially symmetric two-dimensional problems). The porous materials may be heterogeneous and anisotropic. This manual describes all pertinent mathematics related to the governing, boundary, and constitutive equations of the model, as well as the development of the finite element equations used in the code. Instructions are given for constructing Rn3D input files and executing the code, as well as a description of all output files generated by the code. Five verification problems are given that test various aspects of code operation, complete with example input files, FORTRAN programs for the respective analytical solutions, and plots of model results. An example simulation is presented to illustrate the type of problem Rn3D is designed to solve. Finally, instructions are given on how to convert Rn3D to simulate systems other than radon, air, and water.

  12. Effects of aortic irregularities on blood flow.

    PubMed

    Prahl Wittberg, Lisa; van Wyk, Stevin; Fuchs, Laszlo; Gutmark, Ephraim; Backeljauw, Philippe; Gutmark-Little, Iris

    2016-04-01

    Anatomic aortic anomalies are seen in many medical conditions and are known to cause disturbances in blood flow. Turner syndrome (TS) is a genetic disorder occurring only in females where cardiovascular anomalies, particularly of the aorta, are frequently encountered. In this study, numerical simulations are applied to investigate the flow characteristics in four TS patient- related aortic arches (a normal geometry, dilatation, coarctation and elongation of the transverse aorta). The Quemada viscosity model was applied to account for the non-Newtonian behavior of blood. The blood is treated as a mixture consisting of water and red blood cells (RBC) where the RBCs are modeled as a convected scalar. The results show clear geometry effects where the flow structures and RBC distribution are significantly different between the aortas. Transitional flow is observed as a jet is formed due to a constriction in the descending aorta for the coarctation case. RBC dilution is found to vary between the aortas, influencing the WSS. Moreover, the local variations in RBC volume fraction may induce large viscosity variations, stressing the importance of accounting for the non-Newtonian effects. PMID:26104133

  13. Three-Dimensional Ultrasound Measurement of Blood Volume Flow in the Umbilical Cord

    PubMed Central

    Pinter, Stephen Z.; Rubin, Jonathan M.; Kripfgans, Oliver D.; Treadwell, Marjorie C.; Romero, Vivian C.; Richards, Michael S.; Zhang, Man; Hall, Anne L.; Fowlkes, J. Brian

    2013-01-01

    Objectives Three-dimensional (3D) umbilical cord blood volume flow measurement with the intention of providing a straightforward, consistent, and accurate method that overcomes the limitations associated with traditional pulsed-wave Doppler flow measurement and provides a means by which to recognize and manage at-risk pregnancies. Methods The first study involved 3D ultrasound volume flow measurements in seven healthy ewes whose pregnancies ranged from 18 to 19 weeks’ gestation (7 singletons). Sonographic umbilical arterial and venous flow measurements from each fetus were compared to the corresponding average measured arterial/venous flow to assess feasibility of measurement in a static vessel. A second complementary study involved 3D ultrasound volume flow measurements in seven healthy women whose pregnancies ranged from 17.9 to 36.3 weeks’ gestation (6 singletons, 1 twin). Umbilical venous flow measurements were compared to similar flow measurements reported in the literature. Pregnancy outcomes were abstracted from the medical records of the recruited patients. Results In the fetal sheep model, arterial/venous flow comparisons yielded errors of 10% or less for eight out of the nine measurements. In the clinical study, venous flow measurements showed agreement with the literature over a range of gestational ages. Two of the seven patients in the clinical study demonstrated lower flow than anticipated for gestational age; one was subsequently diagnosed with intrauterine growth restriction and the other with preeclampsia. Conclusions Accurate measurements of umbilical blood volume flow can be performed with relative ease in both the sheep model and in humans using the proposed 3D ultrasound flow measurement technique. Results encourage further development of the method as a means for diagnosis and identification of at-risk pregnancies. PMID:23197545

  14. Experimental investigation of compound-specific dilution of solute plumes in saturated porous media: 2-D vs. 3-D flow-through systems.

    PubMed

    Ye, Yu; Chiogna, Gabriele; Cirpka, Olaf; Grathwohl, Peter; Rolle, Massimo

    2015-01-01

    Dilution of solute plumes in groundwater strongly depends on transverse mixing. Thus, the correct parameterization of transverse dispersion is of critical importance for the quantitative description of solute transport. In this study we perform flow-through laboratory experiments to investigate the influence of transport dimensionality on transverse mixing. We present a high-resolution experimental setup to study solute dilution and transverse dispersion in three-dimensional porous media. We conduct multi-tracer experiments in the new 3-D setup and compare the results with the outcomes of analogous tracer experiments performed in a quasi 2-D system. We work under steady-state flow and transport conditions and consider a range of velocities relevant for groundwater flow (0.5-8 m/day). Transverse dispersion coefficients are determined from high-resolution concentration profiles at the outlet of the flow-through chambers (7×7 ports in the 3-D setup and 7 ports in the quasi 2-D system), considering conservative tracers with significantly different aqueous diffusion coefficients, namely fluorescein and dissolved oxygen. To quantify dilution in the 2-D and 3-D systems, we experimentally determine the flux-related dilution index using the flow rates and the concentrations measured at the inlet and outlet ports, and we propose semi-analytical expressions to predict its evolution with travel distance in uniform groundwater flow. The experimental results in the quasi 2-D and 3-D flow-through systems are consistent and show a compound-specific behavior of the transverse dispersion coefficient and its non-linear dependence on the seepage velocity in both setups. The degree of dilution and the compound-specific effects of transverse dispersion are considerably more pronounced in 3-D than in quasi 2-D transport systems.

  15. Development of Inundation Map for Bantayan Island, Cebu Using Delft3D-Flow Storm Surge Simulations of Typhoon Haiyan

    NASA Astrophysics Data System (ADS)

    Cuadra, Camille; Suarez, John Kenneth; Biton, Nophi Ian; Cabacaba, Krichi May; Lapidez, John Phillip; Santiago, Joy; Mahar Francisco Lagmay, Alfredo; Malano, Vicente

    2014-05-01

    On average, 20 typhoons enter the Philippine area of responsibility annually, making it vulnerable to different storm hazards. Apart from the frequency of tropical cyclones, the archipelagic nature of the country makes it particularly prone to storm surges. On 08 November 2013, Haiyan, a Category 5 Typhoon with maximum one-minute sustained wind speed of 315 kph, hit the central region of the Philippines. In its path, the howler devastated Bantayan Island, a popular tourist destination. The island is located north of Cebu City, the second largest metropolis of the Philippines in terms of populace. Having been directly hit by Typhoon Haiyan, Bantayan Island was severely damaged by strong winds and storm surges, with more than 11,000 houses totally destroyed while 5,000 more suffered minor damage. The adverse impacts of possible future storm surge events in the island can only be mitigated if hazard maps that depict inundation of the coastal areas of Bantayan are generated. To create such maps, Delft3D-Flow, a hydrodynamic model was used to simulate storm surges. These simulations were made over a 10-m per pixel resolution Digital Elevation Model (DEM) and the General Bathymetric Chart of the Oceans (GEBCO) bathymetry. The results of the coastal inundation model for Typhoon Haiyan's storm surges were validated using data collected from field work and local government reports. The hydrodynamic model of Bantayan was then calibrated using the field data and further simulations were made with varying typhoon tracks. This was done to generate scenarios on the farthest possible inland incursion of storm surges. The output of the study is a detailed storm surge inundation map that depicts safe zones for development of infrastructure near coastal areas and for construction of coastal protection structures. The storm surge inundation map can also be used as basis for disaster preparedness plans of coastal communities threatened by approaching typhoons.

  16. Lagrangian 3D particle tracking in high-speed flows: Shake-The-Box for multi-pulse systems

    NASA Astrophysics Data System (ADS)

    Novara, Matteo; Schanz, Daniel; Reuther, Nico; Kähler, Christian J.; Schröder, Andreas

    2016-08-01

    The Shake-The-Box (STB) particle tracking technique, recently introduced for time-resolved 3D particle image velocimetry (PIV) images, is applied here to data from a multi-pulse investigation of a turbulent boundary layer flow with adverse pressure gradient in air at 36 m/s ( Re τ = 10,650). The multi-pulse acquisition strategy allows for the recording of four-pulse long time-resolved sequences with a time separation of a few microseconds. The experimental setup consists of a dual-imaging system and a dual-double-cavity laser emitting orthogonal polarization directions to separate the four pulses. The STB particle triangulation and tracking strategy is adapted here to cope with the limited amount of realizations available along the time sequence and to take advantage of the ghost track reduction offered by the use of two independent imaging systems. Furthermore, a correction scheme to compensate for camera vibrations is discussed, together with a method to accurately identify the position of the wall within the measurement domain. Results show that approximately 80,000 tracks can be instantaneously reconstructed within the measurement volume, enabling the evaluation of both dense velocity fields, suitable for spatial gradients evaluation, and highly spatially resolved boundary layer profiles. Turbulent boundary layer profiles obtained from ensemble averaging of the STB tracks are compared to results from 2D-PIV and long-range micro particle tracking velocimetry; the comparison shows the capability of the STB approach in delivering accurate results across a wide range of scales.

  17. Influence of cratonic lithosphere on slab geometry and mantle flow: insights from 3D time-dependent modelling.

    NASA Astrophysics Data System (ADS)

    Taramón, Jorge M.; Rodríguez-González, Juan; Negredo, Ana M.

    2014-05-01

    Recent studies show a clear correlation between the occurrence of flat subduction and the proximity of areas of high elastic/thermal thickness in the overriding plate. A plausible explanation is that cold overriding plates lead to colder mantle wedge, increasing the hydrodynamic suction and decreasing the slab dip. In particular, recent numerical modeling has shown that the presence of cratonic lithosphere in the overriding plate has a significant effect on subducting slabs. In this study we quantify the influence of cratonic areas in the overriding plate on subduction dynamics. We present 3D thermo-mechanical and time-dependent numerical models of buoyancy-driven subduction processes. A non-Newtonian pseudo-plastic rheology is assumed. Different simulations have been performed to quantify the effect of different factors, such as the craton width, thermal thickness and distante to the trench. Modelling results indicate that presence of cratonic lithosphere in the overriding plate produces strong along-trench variations of the slab geometry. These variations are maintained and propagated at great depths as the slab sinks deeper into the mantle. Significant trench-parallel flow in the mantle wedge is generated by time-dependent changes in slab dip. For cases of reduced slab pull, the slab and the base of the craton become coupled, which causes a dramatic reduction of subduction velocity and the formation of a slab gap. The presence of cratons may have an important role on subduction episodicity and provide a new mechanism to explain slab gaps in areas where cratons have been located close to trenches, as is the case of South America and the Cenozoic subduction of North America. We further emphasize that the lithospheric structure of the overriding plate should be taken into account in analysis and modelling studies of subduction zones.

  18. 3D reservoir visualization

    SciTech Connect

    Van, B.T.; Pajon, J.L.; Joseph, P. )

    1991-11-01

    This paper shows how some simple 3D computer graphics tools can be combined to provide efficient software for visualizing and analyzing data obtained from reservoir simulators and geological simulations. The animation and interactive capabilities of the software quickly provide a deep understanding of the fluid-flow behavior and an accurate idea of the internal architecture of a reservoir.

  19. Measurement of Liver Blood Flow: A Review

    PubMed Central

    Stansby, G. P.; Hobbs, K. E. F.; Hawkes, D. J.; Colchester, A. C. F.

    1991-01-01

    The study of hepatic haemodynamics is of importance in understanding both hepatic physiology and disease processes as well as assessing the effects of portosystemic shunting and liver transplantation. The liver has the most complicated circulation of any organ and many physiological and pathological processes can affect it1,2. This review surveys the methods available for assessing liver blood flow, examines the different parameters being measured and outlines problems of applicability and interpretation for each technique. The classification of these techniques is to some extent arbitrary and several so called “different” methods may share certain common principles. The methods reviewed have been classified into two groups (Table 1): those primarily reflecting flow through discrete vessels or to the whole organ and those used to assess local microcirculatory blood flow. All techniques have their advantages and disadvantages and in some situations a combination may provide the most information. In addition, because of the many factors affecting liver blood flow and sinusoidal perfusion, readings in a single subject may vary depending on positioning, recent food intake, anxiety, anaesthesia and drug therapy. This must be borne in mind if different studies are to be meaningfully compared. PMID:1931785

  20. Interplay Between Melt Flow and the 3D Distribution and Morphology of Fe-Rich Phases in AlSi Alloys

    NASA Astrophysics Data System (ADS)

    Mikolajczak, Piotr; Ratke, Lorenz

    2015-03-01

    The presence of Fe aids in establishing the mechanical and physical properties of AlSi alloys and is also one of the main impurities leading to formation of β-Al5FeSi intermetallics. This study aims to understand the effect of fluid flow on the dendritic microstructure with intermetallics in Al-5/7/9 wt pct Si-0.2/0.5/1.0 wt pct Fe alloys that are directionally solidified under defined thermal and fluid flow conditions. We made extensive use of 3D X-ray tomography to obtain a better insight into the morphology and formation of the intermetallics. Three-dimensional (3-D) distribution of intermetallics presented here shows that the growth of large β-Al5FeSi due to forced flow occurs in the eutectic specimen center and together with an increase in the number density of β precipitates. The 3D reconstructions have verified the β shaped to be curved, bent with twining, branched, and to have imprints, holes, and propeller-shaped platelets. The 3D views showed that hole-shaped β arose from the lateral growth around α-Al dendrites. These views also confirmed the phenomenon of shortening of β as an effect of flow in the dendritic region, where β could be fragmented or completely remelted, and ultimately resulting in microstructures with shorter β-Al5FeSi and increases in number density. The analysis revealed an interaction between melt flow, 3D distribution, and the morphology of β-Al5FeSi. The growth of a large and complex group of β intermetallics can reduce the melt flow between dendrites and strengthen pore nucleation and eutectic colonies nucleation, leading to lower permeability of the mushy zone and increased porosity in the castings.

  1. A Modeling of Cerebral Blood Flow Changes due to Head Motion for fNIRS

    NASA Astrophysics Data System (ADS)

    Takahashi, Kosuke; Tanaka, Takayuki; Nara, Hiroyuki; Kaneko, Shun'ichi; Inoue, Masao; Shimizu, Shunji; Kojima, Satoru

    2013-04-01

    A method is proposed for measuring brain activity during exercises involving head motion by using functional near-infrared spectroscopy (fNIRS), which investigates cerebral hemodynamics. Obtaining measurements during exercise is difficult because cerebral blood flow changes due to the head motion component (HMC), in addition to neural activity. HMC is an undesirable artifact in the measurement of hemodynamic response caused by neural activity, and as such, it must be estimated and eliminated. In our experiments, cerebral blood flow and head motion were measured during repeated passive forward bending of the subjects. Head motion was measured by 3-D motion capture, and HMC was estimated by deriving a relation between head motion and cerebral blood flow, where the pitch angle was found to be suitable for estimating HMC. In this research, an assumption was made that cerebral blood flow caused by neural activity and that caused by postural change were additive, and thus HMC was eliminated by subtraction.

  2. Evaluation of 3-D flow structure and corresponding scour holes in the vicinity of a submerged wing dike in a large sand bed river

    NASA Astrophysics Data System (ADS)

    Jamieson, E. C.; Rennie, C. D.; Jacobson, R. B.

    2009-12-01

    Using a boat mounted acoustic Doppler current profiler (ADCP), highly dense single transect measurements were carried out in the vicinity of a submerged wing dike located in the Lower Missouri River near Columbia, Missouri. The Lower Missouri River channel morphology has changed substantially over the last one hundred years as engineering measures such as wing dikes and revetments have been introduced to stabilize the banks and maintain a deep, narrowed and focused thalweg for barge traffic. At high spring flows the wing dikes become submerged, creating a unique combination of vertical flow separation and overtopping (plunging) flow conditions, causing large scale three-dimensional (3-D) turbulent structures to form. On three different days and for a range of discharges, sampling transects at 5 and 20 m spacing were completed, covering the area adjacent to and upstream and downstream of two different wing dikes and their adjacent scour holes. Single transect measurements were interpolated to generate detailed two-dimensional (2-D) bathymetry maps and 3-D flow fields. The principal goal of this research is to evaluate whether an ADCP can identify and measure large scale flow features such as vortex shedding that develop in the vicinity of a submerged wing dike, and whether or not moving boat (single transect) data are sufficient for resolving complex 3-D flow fields. These results have implications for improving boat mounted ADCP measurement techniques and understanding to what extent these instruments can be used for detailed mapping and analysis of complex flows in large rivers. Unlike previous studies, where multiple transects at the same location were averaged for identifying secondary flow features, these results show that spatial averaging from multiple nearby single transects may be more representative of an inherently complex 3-D flow field. Too much averaging of repeated transects could eliminate the true variability in velocity inherent to naturally

  3. Three-dimensional color Doppler reconstruction of intracardiac blood flow in patients with different heart valve diseases.

    PubMed

    De Simone, R; Glombitza, G; Vahl, C F; Meinzer, H P; Hagl, S

    2000-12-15

    An improved perception of the magnitude and dynamics of intracardiac flow disturbances has been made possible by the advent of 3-dimensional (3-D) color Doppler, a new diagnostic procedure developed at our institution. This study describes the new insights derived from 3-D reconstruction of color Doppler flow patterns in patients with different heart valve diseases. The color Doppler flow data from 153 multiplanar transesophageal or transthoracic echocardiographic examinations has been obtained from 133 patients with heart valve disease; 73 patients had mitral regurgitation, 15 had mitral stenosis, 18 had aortic regurgitation, 26 had aortic stenosis, and 21 patients had tricuspid regurgitation. Four patients had pulmonary regurgitation associated with mitral valve disease. The 3-D reconstructions of color Doppler flow signals were accomplished by means of the "Heidelberg Raytracing model," developed at our institution. The 3-D color Doppler reconstructions were obtained in all patients. The 3-D images revealed for the first time the complex spatial distribution of the blood flow abnormalities in the heart chambers caused by different heart valve diseases. New patterns of intracardiac blood flow disturbances were observed and classified. Three-dimensional color Doppler provides a unique noninvasive method that can be easily applied for studying intracardiac blood flow disturbances in clinical practice. PMID:11113410

  4. 3D-Printed Fluidic Devices for Nanoparticle Preparation and Flow-Injection Amperometry Using Integrated Prussian Blue Nanoparticle-Modified Electrodes

    PubMed Central

    Bishop, Gregory W.; Satterwhite, Jennifer E.; Bhakta, Snehasis; Kadimisetty, Karteek; Gillette, Kelsey M.; Chen, Eric; Rusling, James F.

    2015-01-01

    A consumer-grade fused filament fabrication (FFF) 3D printer was used to construct fluidic devices for nanoparticle preparation and electrochemical sensing. Devices were printed using poly(ethylene terephthalate) and featured threaded ports to connect polyetheretherketone (PEEK) tubing via printed fittings prepared from acrylonitrile butadiene styrene (ABS). These devices included channels designed to have 800 × 800 µm2 square cross sections and were semitransparent to allow visualization of the solution-filled channels. A 3D-printed device with a Y-shaped mixing channel was used to prepare Prussian blue nanoparticles (PBNPs) under flow rates of 100 to 2000 µL min−1. PBNPs were then attached to gold electrodes for hydrogen peroxide sensing. 3D-printed devices used for electrochemical measurements featured threaded access ports into which a fitting equipped with reference, counter, and PBNP-modified working electrodes could be inserted. PBNP-modified electrodes enabled amperometric detection of H2O2 in the 3D-printed channel by flow-injection analysis, exhibiting a detection limit of 100 nM and linear response up to 20 µM. These experiments show that a consumer-grade FFF printer can be used to fabricate low-cost fluidic devices for applications similar to those that have been reported with more expensive 3D-printing methods. PMID:25901660

  5. Experiments performed with bubbly flow in vertical pipes at different flow conditions covering the transition region: simulation by coupling Eulerian, Lagrangian and 3D random walks models

    NASA Astrophysics Data System (ADS)

    Muñoz-Cobo, José; Chiva, Sergio; El Aziz Essa, Mohamed; Mendes, Santos

    2012-08-01

    Two phase flow experiments with different superficial velocities of gas and water were performed in a vertical upward isothermal cocurrent air-water flow column with conditions ranging from bubbly flow, with very low void fraction, to transition flow with some cap and slug bubbles and void fractions around 25%. The superficial velocities of the liquid and the gas phases were varied from 0.5 to 3 m/s and from 0 to 0.6 m/s, respectively. Also to check the effect of changing the surface tension on the previous experiments small amounts of 1-butanol were added to the water. These amounts range from 9 to 75 ppm and change the surface tension. This study is interesting because in real cases the surface tension of the water diminishes with temperature, and with this kind of experiments we can study indirectly the effect of changing the temperature on the void fraction distribution. The following axial and radial distributions were measured in all these experiments: void fraction, interfacial area concentration, interfacial velocity, Sauter mean diameter and turbulence intensity. The range of values of the gas superficial velocities in these experiments covered the range from bubbly flow to the transition to cap/slug flow. Also with transition flow conditions we distinguish two groups of bubbles in the experiments, the small spherical bubbles and the cap/slug bubbles. Special interest was devoted to the transition region from bubbly to cap/slug flow; the goal was to understand the physical phenomena that take place during this transition A set of numerical simulations of some of these experiments for bubbly flow conditions has been performed by coupling a Lagrangian code, that tracks the three dimensional motion of the individual bubbles in cylindrical coordinates inside the field of the carrier liquid, to an Eulerian model that computes the magnitudes of continuous phase and to a 3D random walk model that takes on account the fluctuation in the velocity field of the

  6. Caffeine reduces myocardial blood flow during exercise.

    PubMed

    Higgins, John P; Babu, Kavita M

    2013-08-01

    Caffeine consumption has been receiving increased interest from both the medical and lay press, especially given the increased amounts now available in energy products. Acute ingestion of caffeine usually increases cardiac work; however, caffeine impairs the expected proportional increase in myocardial blood flow to match this increased work of the heart, most notably during exercise. This appears to be mainly due to caffeine's effect on blocking adenosine-induced vasodilatation in the coronary arteries in normal healthy subjects. This review summarizes the available medical literature specifically relating to pure caffeine tablet ingestion and reduced exercise coronary blood flow, and suggests possible mechanisms. Further studies are needed to evaluate this effect for other common caffeine-delivery systems, including coffee, energy beverages, and energy gels, which are often used for exercise performance enhancement, especially in teenagers and young athletes.

  7. Caffeine reduces myocardial blood flow during exercise.

    PubMed

    Higgins, John P; Babu, Kavita M

    2013-08-01

    Caffeine consumption has been receiving increased interest from both the medical and lay press, especially given the increased amounts now available in energy products. Acute ingestion of caffeine usually increases cardiac work; however, caffeine impairs the expected proportional increase in myocardial blood flow to match this increased work of the heart, most notably during exercise. This appears to be mainly due to caffeine's effect on blocking adenosine-induced vasodilatation in the coronary arteries in normal healthy subjects. This review summarizes the available medical literature specifically relating to pure caffeine tablet ingestion and reduced exercise coronary blood flow, and suggests possible mechanisms. Further studies are needed to evaluate this effect for other common caffeine-delivery systems, including coffee, energy beverages, and energy gels, which are often used for exercise performance enhancement, especially in teenagers and young athletes. PMID:23764265

  8. Deterministic Aperiodic Sickle Cell Blood Flows

    NASA Astrophysics Data System (ADS)

    Atsaves, Louis; Harris, Wesley

    2013-11-01

    In this paper sickle cell blood flow in the capillaries is modeled as a hydrodynamical system. The hydrodynamical system consists of the axisymmetric unsteady, incompressible Navier-Stokes equations and a set of constitutive equations for oxygen transport. Blood cell deformation is not considered in this paper. The hydrodynamical system is reduced to a system of non-linear partial differential equations that are then transformed into a system of three autonomous non-linear ordinary differential equations and a set of algebraic equations. We examine the hydrodynamical system to discern stable/unstable, periodic/nonperiodic, reversible/irreversible properties of the system. The properties of the solutions are driven in large part by the coefficients of the governing system of equations. These coefficients depend on the physiological properties of the sickle cell blood. The chaotic nature of the onset of crisis in sickle cell patients is identified. Research Assistant.

  9. Myocardial blood flow: Roentgen videodensitometry techniques

    NASA Technical Reports Server (NTRS)

    Smith, H. C.; Robb, R. A.; Wood, E. H.

    1975-01-01

    The current status of roentgen videodensitometric techniques that provide an objective assessment of blood flow at selected sites within the coronary circulation were described. Roentgen videodensitometry employs conventional radiopaque indicators, radiological equipment and coronary angiographic techniques. Roentgen videodensitometry techniques developed in the laboratory during the past nine years, and for the past three years were applied to analysis of angiograms in the clinical cardiac catheterization laboratory.

  10. Red blood cell in simple shear flow

    NASA Astrophysics Data System (ADS)

    Chien, Wei; Hew, Yayu; Chen, Yeng-Long

    2013-03-01

    The dynamics of red blood cells (RBC) in blood flow is critical for oxygen transport, and it also influences inflammation (white blood cells), thrombosis (platelets), and circulatory tumor migration. The physical properties of a RBC can be captured by modeling RBC as lipid membrane linked to a cytoskeletal spectrin network that encapsulates cytoplasm rich in hemoglobin, with bi-concave equilibrium shape. Depending on the shear force, RBC elasticity, membrane viscosity, and cytoplasm viscosity, RBC can undergo tumbling, tank-treading, or oscillatory motion. We investigate the dynamic state diagram of RBC in shear and pressure-driven flow using a combined immersed boundary-lattice Boltzmann method with a multi-scale RBC model that accurately captures the experimentally established RBC force-deformation relation. It is found that the tumbling (TU) to tank-treading (TT) transition occurs as shear rate increases for cytoplasm/outer fluid viscosity ratio smaller than 0.67. The TU frequency is found to be half of the TT frequency, in agreement with experiment observations. Larger viscosity ratios lead to the disappearance of stable TT phase and unstable complex dynamics, including the oscillation of the symmetry axis of the bi-concave shape perpendicular to the flow direction. The dependence on RBC bending rigidity, shear modulus, the order of membrane spectrin network and fluid field in the unstable region will also be discussed.

  11. Computational Analysis of Human Blood Flow

    NASA Astrophysics Data System (ADS)

    Panta, Yogendra; Marie, Hazel; Harvey, Mark

    2009-11-01

    Fluid flow modeling with commercially available computational fluid dynamics (CFD) software is widely used to visualize and predict physical phenomena related to various biological systems. In this presentation, a typical human aorta model was analyzed assuming the blood flow as laminar with complaint cardiac muscle wall boundaries. FLUENT, a commercially available finite volume software, coupled with Solidworks, a modeling software, was employed for the preprocessing, simulation and postprocessing of all the models.The analysis mainly consists of a fluid-dynamics analysis including a calculation of the velocity field and pressure distribution in the blood and a mechanical analysis of the deformation of the tissue and artery in terms of wall shear stress. A number of other models e.g. T branches, angle shaped were previously analyzed and compared their results for consistency for similar boundary conditions. The velocities, pressures and wall shear stress distributions achieved in all models were as expected given the similar boundary conditions. The three dimensional time dependent analysis of blood flow accounting the effect of body forces with a complaint boundary was also performed.

  12. Blood flow dynamics in heart failure

    NASA Technical Reports Server (NTRS)

    Shoemaker, J. K.; Naylor, H. L.; Hogeman, C. S.; Sinoway, L. I.

    1999-01-01

    BACKGROUND: Exercise intolerance in heart failure (HF) may be due to inadequate vasodilation, augmented vasoconstriction, and/or altered muscle metabolic responses that lead to fatigue. METHODS AND RESULTS: Vascular and metabolic responses to rhythmic forearm exercise were tested in 9 HF patients and 9 control subjects (CTL) during 2 protocols designed to examine the effect of HF on the time course of oxygen delivery versus uptake (protocol 1) and on vasoconstriction during exercise with 50 mm Hg pressure about the forearm to evoke a metaboreflex (protocol 2). In protocol 1, venous lactate and H+ were greater at 4 minutes of exercise in HF versus CTL (P<0.05) despite similar blood flow and oxygen uptake responses. In protocol 2, mean arterial pressure increased similarly in each group during ischemic exercise. In CTL, forearm blood flow and vascular conductance were similar at the end of ischemic and ambient exercise. In HF, forearm blood flow and vascular conductance were reduced during ischemic exercise compared with the ambient trial. CONCLUSIONS: Intrinsic differences in skeletal muscle metabolism, not vasodilatory dynamics, must account for the augmented glycolytic metabolic responses to moderate-intensity exercise in class II and III HF. The inability to increase forearm vascular conductance during ischemic handgrip exercise, despite a normal pressor response, suggests that enhanced vasoconstriction of strenuously exercising skeletal muscle contributes to exertional fatigue in HF.

  13. A numerical analysis of the aortic blood flow pattern during pulsed cardiopulmonary bypass.

    PubMed

    Gramigna, V; Caruso, M V; Rossi, M; Serraino, G F; Renzulli, A; Fragomeni, G

    2015-01-01

    In the modern era, stroke remains a main cause of morbidity after cardiac surgery despite continuing improvements in the cardiopulmonary bypass (CPB) techniques. The aim of the current work was to numerically investigate the blood flow in aorta and epiaortic vessels during standard and pulsed CPB, obtained with the intra-aortic balloon pump (IABP). A multi-scale model, realized coupling a 3D computational fluid dynamics study with a 0D model, was developed and validated with in vivo data. The presence of IABP improved the flow pattern directed towards the epiaortic vessels with a mean flow increase of 6.3% and reduced flow vorticity. PMID:24962383

  14. Virtual Interventions for Image-based Blood Flow Computation

    PubMed Central

    Xiong, Guanglei; Choi, Gilwoo; Taylor, Charles A.

    2011-01-01

    Image-based blood flow computation provides great promise for evaluation of vascular devices and assessment of surgical procedures. However, many previous studies employ idealized arterial and device models or only patient-specific models from the image data after device deployment, since the tools for model construction are unavailable or limited and tedious to use. Moreover, in contrast to retrospective studies from existing data, there is a pressing need for prospective analysis with the goal of surgical planning. Therefore, it is necessary to construct models with deployed devices in a fast, virtual and interactive fashion. The goal of this paper is to develop new geometric methods to deploy stents or stent grafts virtually to patient-specific geometric models constructed from a 3D segmentation of medical images. A triangular surface representing the vessel lumen boundary is extracted from the segmentation. The diseased portion is either clipped and replaced by the surface of a deployed device or rerouted in the case of a bypass graft. For diseased arteries close to bifurcations, bifurcated device models are generated. A method to map a 2D strut pattern on the surface of a device is also presented. We demonstrate three applications of our methods in personalized surgical planning for aortic aneurysms, aortic coarctation, and coronary artery stenosis using blood flow computation. Our approach enables prospective model construction and may help to expand the throughput required by routine clinical uses in the future. PMID:22121255

  15. A high performance biometric signal and image processing method to reveal blood perfusion towards 3D oxygen saturation mapping

    NASA Astrophysics Data System (ADS)

    Imms, Ryan; Hu, Sijung; Azorin-Peris, Vicente; Trico, Michaël.; Summers, Ron

    2014-03-01

    Non-contact imaging photoplethysmography (PPG) is a recent development in the field of physiological data acquisition, currently undergoing a large amount of research to characterize and define the range of its capabilities. Contact-based PPG techniques have been broadly used in clinical scenarios for a number of years to obtain direct information about the degree of oxygen saturation for patients. With the advent of imaging techniques, there is strong potential to enable access to additional information such as multi-dimensional blood perfusion and saturation mapping. The further development of effective opto-physiological monitoring techniques is dependent upon novel modelling techniques coupled with improved sensor design and effective signal processing methodologies. The biometric signal and imaging processing platform (bSIPP) provides a comprehensive set of features for extraction and analysis of recorded iPPG data, enabling direct comparison with other biomedical diagnostic tools such as ECG and EEG. Additionally, utilizing information about the nature of tissue structure has enabled the generation of an engineering model describing the behaviour of light during its travel through the biological tissue. This enables the estimation of the relative oxygen saturation and blood perfusion in different layers of the tissue to be calculated, which has the potential to be a useful diagnostic tool.

  16. 3D bloodstain pattern analysis: ballistic reconstruction of the trajectories of blood drops and determination of the centres of origin of the bloodstains.

    PubMed

    Buck, Ursula; Kneubuehl, Beat; Näther, Silvio; Albertini, Nicola; Schmidt, Lars; Thali, Michael

    2011-03-20

    For crime scene investigation in cases of homicide, the pattern of bloodstains at the incident site is of critical importance. The morphology of the bloodstain pattern serves to determine the approximate blood source locations, the minimum number of blows and the positioning of the victim. In the present work, the benefits of the three-dimensional bloodstain pattern analysis, including the ballistic approximation of the trajectories of the blood drops, will be demonstrated using two illustrative cases. The crime scenes were documented in 3D, using the non-contact methods digital photogrammetry, tachymetry and laser scanning. Accurate, true-to-scale 3D models of the crime scenes, including the bloodstain pattern and the traces, were created. For the determination of the areas of origin of the bloodstain pattern, the trajectories of up to 200 well-defined bloodstains were analysed in CAD and photogrammetry software. The ballistic determination of the trajectories was performed using ballistics software. The advantages of this method are the short preparation time on site, the non-contact measurement of the bloodstains and the high accuracy of the bloodstain analysis. It should be expected that this method delivers accurate results regarding the number and position of the areas of origin of bloodstains, in particular the vertical component is determined more precisely than using conventional methods. In both cases relevant forensic conclusions regarding the course of events were enabled by the ballistic bloodstain pattern analysis. PMID:20598820

  17. 3D bloodstain pattern analysis: ballistic reconstruction of the trajectories of blood drops and determination of the centres of origin of the bloodstains.

    PubMed

    Buck, Ursula; Kneubuehl, Beat; Näther, Silvio; Albertini, Nicola; Schmidt, Lars; Thali, Michael

    2011-03-20

    For crime scene investigation in cases of homicide, the pattern of bloodstains at the incident site is of critical importance. The morphology of the bloodstain pattern serves to determine the approximate blood source locations, the minimum number of blows and the positioning of the victim. In the present work, the benefits of the three-dimensional bloodstain pattern analysis, including the ballistic approximation of the trajectories of the blood drops, will be demonstrated using two illustrative cases. The crime scenes were documented in 3D, using the non-contact methods digital photogrammetry, tachymetry and laser scanning. Accurate, true-to-scale 3D models of the crime scenes, including the bloodstain pattern and the traces, were created. For the determination of the areas of origin of the bloodstain pattern, the trajectories of up to 200 well-defined bloodstains were analysed in CAD and photogrammetry software. The ballistic determination of the trajectories was performed using ballistics software. The advantages of this method are the short preparation time on site, the non-contact measurement of the bloodstains and the high accuracy of the bloodstain analysis. It should be expected that this method delivers accurate results regarding the number and position of the areas of origin of bloodstains, in particular the vertical component is determined more precisely than using conventional methods. In both cases relevant forensic conclusions regarding the course of events were enabled by the ballistic bloodstain pattern analysis.

  18. Standing-wave-excited multiplanar fluorescence in a laser scanning microscope reveals 3D information on red blood cells

    NASA Astrophysics Data System (ADS)

    Amor, Rumelo; Mahajan, Sumeet; Amos, William Bradshaw; McConnell, Gail

    2014-12-01

    Standing-wave excitation of fluorescence is highly desirable in optical microscopy because it improves the axial resolution. We demonstrate here that multiplanar excitation of fluorescence by a standing wave can be produced in a single-spot laser scanning microscope by placing a plane reflector close to the specimen. We report here a variation in the intensity of fluorescence of successive planes related to the Stokes shift of the dye. We show by the use of dyes specific for the cell membrane how standing-wave excitation can be exploited to generate precise contour maps of the surface membrane of red blood cells, with an axial resolution of ~90 nm. The method, which requires only the addition of a plane mirror to an existing confocal laser scanning microscope, may well prove useful in studying diseases which involve the red cell membrane, such as malaria.

  19. Standing-wave-excited multiplanar fluorescence in a laser scanning microscope reveals 3D information on red blood cells.

    PubMed

    Amor, Rumelo; Mahajan, Sumeet; Amos, William Bradshaw; McConnell, Gail

    2014-12-08

    Standing-wave excitation of fluorescence is highly desirable in optical microscopy because it improves the axial resolution. We demonstrate here that multiplanar excitation of fluorescence by a standing wave can be produced in a single-spot laser scanning microscope by placing a plane reflector close to the specimen. We report here a variation in the intensity of fluorescence of successive planes related to the Stokes shift of the dye. We show by the use of dyes specific for the cell membrane how standing-wave excitation can be exploited to generate precise contour maps of the surface membrane of red blood cells, with an axial resolution of ≈90 nm. The method, which requires only the addition of a plane mirror to an existing confocal laser scanning microscope, may well prove useful in studying diseases which involve the red cell membrane, such as malaria.

  20. Electromagnetic blood flowmeters and flow probes: theoretic and practical considerations.

    PubMed

    Scott, E A; Sandler, G A

    1978-09-01

    Electromagnetic blood flowmeters and flow probes are used to measure blood flow in blood vessels throughout the circulatory system. The principle of this measuring device is based on laws of electromagnetic induction discovered in the 19th century. The instrument has been predominantly used in research, but is presently used in human cardiovascular units to measure blood flow in blood vessels, and in prosthesis in conjection with cardiovascular surgical procedures. Electromagnetic flow equipment provides the most accurate measurement (in vivo) of blood flow available, both for acute and chronic implants. This report presents some of the theoretic and practical considerations for effective use of this instrument.

  1. Lagrangian Coherent Structures in Blood Flow

    NASA Astrophysics Data System (ADS)

    Shadden, Shawn

    2008-11-01

    Knowledge of fluid transport is particularly compelling in understanding the function of cardiovascular processes. Transport of chemicals, cells, and compounds in the vascular system is influenced by local flow structures in large vessels. Local flow features can also induce cell-signaling pathways and biologic response critical to maintaining health or disease progression. Complex vessel geometry, the pulsatile pumping of blood, and low Reynolds number turbulence leads to complex flow features in large vessels. However, we are gaining the ability to study transport in large vessels with unprecedented detail, which is in part allowing us to broaden the ``shear-centric'' view of hemodynamics. In this talk we will describe the application of computational fluid mechanics and the computation of Lagrangian coherent structures (LCS) to study transport in various cardiovascular applications. We will discuss some of the challenges of this work and some results of computing LCS in several regions of the vascular system. In collaboration with Charles Taylor, Stanford University.

  2. Gender differences in regional cerebral blood flow

    SciTech Connect

    Gur, R.E.; Gur, R.C. )

    1990-01-01

    Gender differences have been noted in neurobehavioral studies. The 133xenon inhalation method for measuring regional cerebral blood flow (rCBF) can contribute to the understanding of the neural basis of gender differences in brain function. Few studies have examined gender differences in rCBF. In studies of normal subjects, women have higher rates of CBF than men, and this is related to age. Usually by the sixth decade men and women have similar flow rates. Fewer studies on rCBF in schizophrenia have examined sex differences. The pattern of higher flows for females maintains, but its correlates with gender differences in clinical as well as other parameters of brain function remain to be examined.

  3. Unsteady Flow in Stenotic Blood Vessels

    NASA Astrophysics Data System (ADS)

    Rayz, Vitaliy L.; Devi Williamson, Shobha; Berger, Stanley A.; Saloner, David

    2003-11-01

    Recent studies show that many heart attacks and strokes occur from sudden rupture of partially occluding atherosclerotic plaque rather than total vessel occlusion. Our goal is to understand how the mechanical forces induced by blood flow on specific plaque deposits makes them vulnerable to rupture. Models of severely stenotic carotid bifurcations are created from MR images and grids generated for the flow domains. The three-dimensional, unsteady, incompressible Navier-Stokes equations in finite-volume form are solved numerically using physiological boundary conditions. During systole a high velocity jet forms at the stenotic throat in one of the branches, and a long recirculation zone is observed downstream of the plaque. During diastole the flow is more stagnant. The flow is highly three-dimensional and unsteady with chaotic streamlines. Whereas flow in healthy arteries is laminar, irregular geometries and sharp changes in vessel diameter of a severely stenotic artery significantly disrupt the flow, with consequences for shear and normal wall stresses at the wall, and important implications for plaque stability. Supported by NIH Grant HL61823

  4. Foetal placental blood flow in the lamb

    PubMed Central

    Faber, J. Job; Green, Thomas J.

    1972-01-01

    1. Fifteen sheep foetuses of 1·5-5·2 kg body weight were prepared with indwelling arterial and venous catheters for experimentation one to six days later. 2. Unanaesthetized foetuses were found to have mean arterial and central venous blood pressures of 40 ± 1·5 (S.E. of mean) and 2·0 ± 0·3 (S.E. of mean) mm Hg respectively, compared to intra-uterine pressure. Intra-uterine pressure was 16 ± 0·8 (S.E. of mean) mm Hg with respect to atmospheric pressure at mid-uterine level. 3. Mean placental blood flow of the foetuses was 199 ± 20 (S.E. of mean) ml./(min.kg body wt.). Mean cardiac output in eleven of the foetuses was 658 ± 102 (S.E. of mean) ml./(min.kg). 4. Mean foetal and maternal colloid osmotic pressures were 17·5 ± 0·7 (S.E. of mean) and 20·5 ± 0·6 (S.E. of mean) mm Hg respectively at 38° C. 5. Intravenous infusions into six ewes of 1·8 mole of mannitol and 0·4 mole of NaCl resulted in significant increases in foetal plasma osmolarity, sodium, potassium, and haemoglobin concentrations, without detectable transfer of mannitol to the foetal circulation. 6. In the sheep placenta there is osmotic and hydrostatic equilibration of water. As a consequence, there should be an interaction between foetal placental blood flow and foetal water exchange with the maternal circulation. It was concluded that this interaction tends to stabilize foetal placental blood flow. PMID:5039279

  5. Regional cerebral blood flow in childhood headache

    SciTech Connect

    Roach, E.S.; Stump, D.A.

    1989-06-01

    Regional cerebral blood flow (rCBF) was measured in 16 cranial regions in 23 children and adolescents with frequent headaches using the non-invasive Xenon-133 inhalation technique. Blood flow response to 5% carbon dioxide (CO2) was also determined in 21 patients, while response to 50% oxygen was measured in the two patients with hemoglobinopathy. Included were 10 patients with a clinical diagnosis of migraine, 4 with musculoskeletal headaches, and 3 with features of both types. Also studied were 2 patients with primary thrombocythemia, 2 patients with hemoglobinopathy and headaches, 1 patient with polycythemia, and 1 with headaches following trauma. With two exceptions, rCBF determinations were done during an asymptomatic period. Baseline rCBF values tended to be higher in these young patients than in young adults done in our laboratory. Localized reduction in the expected blood flow surge after CO2 inhalation, most often noted posteriorly, was seen in 8 of the 13 vascular headaches, but in none of the musculoskeletal headache group. Both patients with primary thrombocythemia had normal baseline flow values and altered responsiveness to CO2 similar to that seen in migraineurs; thus, the frequently reported headache and transient neurologic signs with primary thrombocythemia are probably not due to microvascular obstruction as previously suggested. These data support the concept of pediatric migraine as a disorder of vasomotor function and also add to our knowledge of normal rCBF values in younger patients. Demonstration of altered vasomotor reactivity to CO2 could prove helpful in children whose headache is atypical.

  6. Regulation of cerebral blood flow during exercise.

    PubMed

    Querido, Jordan S; Sheel, A William

    2007-01-01

    Constant cerebral blood flow (CBF) is vital to human survival. Originally thought to receive steady blood flow, the brain has shown to experience increases in blood flow during exercise. Although increases have not consistently been documented, the overwhelming evidence supporting an increase may be a result of an increase in brain metabolism. While an increase in metabolism may be the underlying causative factor for the increase in CBF during exercise, there are many modulating variables. Arterial blood gas tensions, most specifically the partial pressure of carbon dioxide, strongly regulate CBF by affecting cerebral vessel diameter through changes in pH, while carbon dioxide reactivity increases from rest to exercise. Muscle mechanoreceptors may contribute to the initial increase in CBF at the onset of exercise, after which exercise-induced hyperventilation tends to decrease flow by pial vessel vasoconstriction. Although elite athletes may benefit from hyperoxia during intense exercise, cerebral tissue is well protected during exercise, and cerebral oxygenation does not appear to pose a limiting factor to exercise performance. The role of arterial blood pressure is important to the increase in CBF during exercise; however, during times of acute hypotension such as during diastole at high-intensity exercise or post-exercise hypotension, cerebral autoregulation may be impaired. The impairment of an increase in cardiac output during exercise with a large muscle mass similarly impairs the increase in CBF velocity, suggesting that cardiac output may play a key role in the CBF response to exercise. Glucose uptake and CBF do not appear to be related; however, there is growing evidence to suggest that lactate is used as a substrate when glucose levels are low. Traditionally thought to have no influence, neural innervation appears to be a protective mechanism to large increases in cardiac output. Changes in middle cerebral arterial velocity are independent of changes in

  7. Renal pericytes: regulators of medullary blood flow

    PubMed Central

    Kennedy-Lydon, T M; Crawford, C; Wildman, S S P; Peppiatt-Wildman, C M

    2013-01-01

    Regulation of medullary blood flow (MBF) is essential in maintaining normal kidney function. Blood flow to the medulla is supplied by the descending vasa recta (DVR), which arise from the efferent arterioles of juxtamedullary glomeruli. DVR are composed of a continuous endothelium, intercalated with smooth muscle-like cells called pericytes. Pericytes have been shown to alter the diameter of isolated and in situ DVR in response to vasoactive stimuli that are transmitted via a network of autocrine and paracrine signalling pathways. Vasoactive stimuli can be released by neighbouring tubular epithelial, endothelial, red blood cells and neuronal cells in response to changes in NaCl transport and oxygen tension. The experimentally described sensitivity of pericytes to these stimuli strongly suggests their leading role in the phenomenon of MBF autoregulation. Because the debate on autoregulation of MBF fervently continues, we discuss the evidence favouring a physiological role for pericytes in the regulation of MBF and describe their potential role in tubulo-vascular cross-talk in this region of the kidney. Our review also considers current methods used to explore pericyte activity and function in the renal medulla. PMID:23126245

  8. Endotoxin and β-1,3-d-Glucan in Concentrated Ambient Particles Induce Rapid Increase in Blood Pressure in Controlled Human Exposures.

    PubMed

    Zhong, Jia; Urch, Bruce; Speck, Mary; Coull, Brent A; Koutrakis, Petros; Thorne, Peter S; Scott, James; Liu, Ling; Brook, Robert D; Behbod, Behrooz; Gibson, Heike; Silverman, Frances; Mittleman, Murray A; Baccarelli, Andrea A; Gold, Diane R

    2015-09-01

    Short-term exposure to particulate matter (PM) is associated with increased blood pressure (BP) in epidemiological studies. Understanding the impact of specific PM components on BP is essential in developing effective risk-reduction strategies. We investigated the association between endotoxin and β-1,3-d-Glucan-two major biological PM components-and BP. We also examined whether vascular endothelial growth factor, a vasodilatory inflammatory marker, modified these associations. We conducted a single-blind, randomized, crossover trial of controlled human exposure to concentrated ambient particles with 50 healthy adults. Particle-associated-endotoxin and β-1,3-d-Glucan were sampled using polycarbonate-membrane-filters. Supine resting systolic BP and diastolic BP were measured pre-, 0.5-hour post-, and 20-hour postexposure. Urine vascular endothelial growth factor concentration was determined using enzyme-linked immunosorbant assay and creatinine-corrected. Exposures to endotoxin and β-1,3-d-Glucan for 130 minutes were associated with increases in BPs: at 0.5-hour postexposure, every doubling in endotoxin concentration was associated with 1.73 mm Hg higher systolic BP (95% confidence interval, 0.28, 3.18; P=0.02) and 2.07 mm Hg higher diastolic BP (95% confidence interval, 0.74, 3.39; P=0.003); every doubling in β-1,3-d-Glucan concentration was associated with 0.80 mm Hg higher systolic BP (95% confidence interval, -0.07, 1.67; P=0.07) and 0.88 mm Hg higher diastolic BP (95% confidence interval, 0.09, 1.66; P=0.03). Vascular endothelial growth factor rose after concentrated ambient particle endotoxin exposure and attenuated the association between endotoxin and 0.5-hour postexposure diastolic BP (Pinteraction=0.02). In healthy adults, short-term endotoxin and β-1,3-d-Glucan exposures were associated with increased BP. Our findings suggest that the biological PM components contribute to PM-related cardiovascular outcomes, and postexposure vascular endothelial

  9. 3D discrete angiogenesis dynamic model and stochastic simulation for the assessment of blood perfusion coefficient and impact on heat transfer between nanoparticles and malignant tumors.

    PubMed

    Yifat, Jonathan; Gannot, Israel

    2015-03-01

    Early detection of malignant tumors plays a crucial role in the survivability chances of the patient. Therefore, new and innovative tumor detection methods are constantly searched for. Tumor-specific magnetic-core nano-particles can be used with an alternating magnetic field to detect and treat tumors by hyperthermia. For the analysis of the method effectiveness, the bio-heat transfer between the nanoparticles and the tissue must be carefully studied. Heat diffusion in biological tissue is usually analyzed using the Pennes Bio-Heat Equation, where blood perfusion plays an important role. Malignant tumors are known to initiate an angiogenesis process, where endothelial cell migration from neighboring vasculature eventually leads to the formation of a thick blood capillary network around them. This process allows the tumor to receive its extensive nutrition demands and evolve into a more progressive and potentially fatal tumor. In order to assess the effect of angiogenesis on the bio-heat transfer problem, we have developed a discrete stochastic 3D model & simulation of tumor-induced angiogenesis. The model elaborates other angiogenesis models by providing high resolution 3D stochastic simulation, capturing of fine angiogenesis morphological features, effects of dynamic sprout thickness functions, and stochastic parent vessel generator. We show that the angiogenesis realizations produced are well suited for numerical bio-heat transfer analysis. Statistical study on the angiogenesis characteristics was derived using Monte Carlo simulations. According to the statistical analysis, we provide analytical expression for the blood perfusion coefficient in the Pennes equation, as a function of several parameters. This updated form of the Pennes equation could be used for numerical and analytical analyses of the proposed detection and treatment method.

  10. 3D discrete angiogenesis dynamic model and stochastic simulation for the assessment of blood perfusion coefficient and impact on heat transfer between nanoparticles and malignant tumors.

    PubMed

    Yifat, Jonathan; Gannot, Israel

    2015-03-01

    Early detection of malignant tumors plays a crucial role in the survivability chances of the patient. Therefore, new and innovative tumor detection methods are constantly searched for. Tumor-specific magnetic-core nano-particles can be used with an alternating magnetic field to detect and treat tumors by hyperthermia. For the analysis of the method effectiveness, the bio-heat transfer between the nanoparticles and the tissue must be carefully studied. Heat diffusion in biological tissue is usually analyzed using the Pennes Bio-Heat Equation, where blood perfusion plays an important role. Malignant tumors are known to initiate an angiogenesis process, where endothelial cell migration from neighboring vasculature eventually leads to the formation of a thick blood capillary network around them. This process allows the tumor to receive its extensive nutrition demands and evolve into a more progressive and potentially fatal tumor. In order to assess the effect of angiogenesis on the bio-heat transfer problem, we have developed a discrete stochastic 3D model & simulation of tumor-induced angiogenesis. The model elaborates other angiogenesis models by providing high resolution 3D stochastic simulation, capturing of fine angiogenesis morphological features, effects of dynamic sprout thickness functions, and stochastic parent vessel generator. We show that the angiogenesis realizations produced are well suited for numerical bio-heat transfer analysis. Statistical study on the angiogenesis characteristics was derived using Monte Carlo simulations. According to the statistical analysis, we provide analytical expression for the blood perfusion coefficient in the Pennes equation, as a function of several parameters. This updated form of the Pennes equation could be used for numerical and analytical analyses of the proposed detection and treatment method. PMID:24462603

  11. Inertia-dependent dynamics of three-dimensional vesicles and red blood cells in shear flow.

    PubMed

    Luo, Zheng Yuan; Wang, Shu Qi; He, Long; Xu, Feng; Bai, Bo Feng

    2013-10-28

    A three-dimensional (3D) simulation study of the effect of inertia on the dynamics of vesicles and red blood cells (RBCs) has not been reported. Here, we developed a 3D model based on the front tracking method to investigate how inertia affects the dynamics of spherical/non-spherical vesicles and biconcave-shaped RBCs with the Reynolds number ranging from 0.1 to 10. The results showed that inertia induced non-spherical vesicles transitioned from tumbling to swinging, which was not observed in previous 2D models. The critical viscosity ratio of inner/outer fluids for the tumbling–swinging transition remarkably increased with an increasing Reynolds number. The deformation of vesicles was greatly enhanced by inertia, and the frequency of tumbling and tank-treading was significantly decreased by inertia. We also found that RBCs can transit from tumbling to steady tank-treading through the swinging regime when the Reynolds number increased from 0.1 to 10. These results indicate that inertia needs to be considered at moderate Reynolds number (Re ~ 1) in the study of blood flow in the human body and the flow of deformable particle suspension in inertial microfluidic devices. The developed 3D model provided new insights into the dynamics of RBCs under shear flow, thus holding great potential to better understand blood flow behaviors under normal/disease conditions.

  12. Integrative regulation of human brain blood flow

    PubMed Central

    Willie, Christopher K; Tzeng, Yu-Chieh; Fisher, Joseph A; Ainslie, Philip N

    2014-01-01

    Herein, we review mechanisms regulating cerebral blood flow (CBF), with specific focus on humans. We revisit important concepts from the older literature and describe the interaction of various mechanisms of cerebrovascular control. We amalgamate this broad scope of information into a brief review, rather than detailing any one mechanism or area of research. The relationship between regulatory mechanisms is emphasized, but the following three broad categories of control are explicated: (1) the effect of blood gases and neuronal metabolism on CBF; (2) buffering of CBF with changes in blood pressure, termed cerebral autoregulation; and (3) the role of the autonomic nervous system in CBF regulation. With respect to these control mechanisms, we provide evidence against several canonized paradigms of CBF control. Specifically, we corroborate the following four key theses: (1) that cerebral autoregulation does not maintain constant perfusion through a mean arterial pressure range of 60–150 mmHg; (2) that there is important stimulatory synergism and regulatory interdependence of arterial blood gases and blood pressure on CBF regulation; (3) that cerebral autoregulation and cerebrovascular sensitivity to changes in arterial blood gases are not modulated solely at the pial arterioles; and (4) that neurogenic control of the cerebral vasculature is an important player in autoregulatory function and, crucially, acts to buffer surges in perfusion pressure. Finally, we summarize the state of our knowledge with respect to these areas, outline important gaps in the literature and suggest avenues for future research. PMID:24396059

  13. Measurement of cerebral blood flow rate and its relationship with brain function using optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Liu, Jian; Wang, Yi; Zhao, Yuqian; Dou, Shidan; Ma, Yushu; Ma, Zhenhe

    2016-03-01

    Activity of brain neurons will lead to changes in local blood flow rate (BFR). Thus, it is important to measure the local BFR of cerebral cortex on research of neuron activity in vivo, such as rehabilitation evaluation after stroke, etc. Currently, laser Doppler flowmetry is commonly used for blood flow measurement, however, relatively low resolution limits its application. Optical coherence tomography (OCT) is a powerful noninvasive 3D imaging modality with high temporal and spatial resolutions. Furthermore, OCT can provide flow distribution image by calculating Doppler frequency shift which makes it possible for blood flow rate measurement. In this paper, we applied OCT to measure the blood flow rate of the primary motor cortex in rats. The animal was immobilized and anesthetized with isoflurane, an incision was made along the sagittal suture, and bone was exposed. A skull window was opened on the primary motor cortex. Then, blood flow rate changes in the primary motor cortex were monitored by our homemade spectral domain OCT with a stimulation of the passive movement of the front legs. Finally, we established the relationship between blood flow rate and the test design. The aim is to demonstrate the potential of OCT in the evaluation of cerebral cortex function.

  14. Gut blood flow in the estuarine crocodile, Crocodylus porosus.

    PubMed

    Axelsson, M; Fritsche, R; Holmgren, S; Grove, D J; Nilsson, S

    1991-08-01

    Simultaneous recordings of blood flow in the right and left aorta and carotid and coeliac artery were made in the crocodile, Crocodylus porosus at rest and during various stimuli. In resting animals the right aorta and carotid artery flow profiles resembled the recordings obtained in the caiman (Axelsson et al. 1989a), with an anterograde blood flow throughout the cardiac cycle. As in the caiman, the left aorta flow profile was complex with both anterograde and retrograde blood flow during the cardiac cycle, and a net left aorta blood flow near zero at rest. The coeliac artery blood flow profile did not show the complex pattern seen in the upper aorta, immediately suggesting that most of the coeliac artery blood originates elsewhere. We believe that coeliac artery blood flow in the resting animal derives from the right aorta via the abdominal anastomosis between the two aortas. Feeding induced an increase in the coeliac artery and left aorta blood flow, probably due to a decrease in visceral vascular resistance, and hence coeliac arterial and the left aorta blood pressure, which facilitates blood flow (from right to left aorta) through the foramen of Panizza. During short 'fright dives', heart rate fell and there was a decrease in the recorded blood flows: carotid artery blood flow did not decrease to the same extent as the RAo and coeliac artery flow, indicating some capacity for redistribution of blood to the cephalic circuits during diving. Similarly, a near-unimpaired carotid artery blood flow was maintained after adrenaline injection. Substance P increased the coeliac artery blood flow and produced a right-to-left cardiac shunt, probably by construction of the pulmonary vasculature.

  15. Thermoregulatory control of finger blood flow

    NASA Technical Reports Server (NTRS)

    Wenger, C. B.; Roberts, M. F.; Nadel, E. R.; Stolwijk, J. A. J.

    1975-01-01

    In the present experiment, exercise was used to vary internal temperature and ambient air heat control was used to vary skin temperature. Finger temperature was fixed at about 35.7 C. Esophageal temperature was measured with a thermocouple at the level of the left atrium, and mean skin temperature was calculated from a weighted mean of thermocouple temperatures at different skin sites. Finger blood flow was measured by electrocapacitance plethysmography. An equation in these quantities is given which accounts for the data garnered.

  16. Calculation of three-dimensional (3-D) internal flow by means of the velocity-vorticity formulation on a staggered grid

    NASA Technical Reports Server (NTRS)

    Stremel, Paul M.

    1995-01-01

    A method has been developed to accurately compute the viscous flow in three-dimensional (3-D) enclosures. This method is the 3-D extension of a two-dimensional (2-D) method developed for the calculation of flow over airfoils. The 2-D method has been tested extensively and has been shown to accurately reproduce experimental results. As in the 2-D method, the 3-D method provides for the non-iterative solution of the incompressible Navier-Stokes equations by means of a fully coupled implicit technique. The solution is calculated on a body fitted computational mesh incorporating a staggered grid methodology. In the staggered grid method, the three components of vorticity are defined at the centers of the computational cell sides, while the velocity components are defined as normal vectors at the centers of the computational cell faces. The staggered grid orientation provides for the accurate definition of the vorticity components at the vorticity locations, the divergence of vorticity at the mesh cell nodes and the conservation of mass at the mesh cell centers. The solution is obtained by utilizing a fractional step solution technique in the three coordinate directions. The boundary conditions for the vorticity and velocity are calculated implicitly as part of the solution. The method provides for the non-iterative solution of the flow field and satisfies the conservation of mass and divergence of vorticity to machine zero at each time step. To test the method, the calculation of simple driven cavity flows have been computed. The driven cavity flow is defined as the flow in an enclosure driven by a moving upper plate at the top of the enclosure. To demonstrate the ability of the method to predict the flow in arbitrary cavities, results will he shown for both cubic and curved cavities.

  17. Cerebral blood flow in humans following resuscitation from cardiac arrest

    SciTech Connect

    Cohan, S.L.; Mun, S.K.; Petite, J.; Correia, J.; Tavelra Da Silva, A.T.; Waldhorn, R.E.

    1989-06-01

    Cerebral blood flow was measured by xenon-133 washout in 13 patients 6-46 hours after being resuscitated from cardiac arrest. Patients regaining consciousness had relatively normal cerebral blood flow before regaining consciousness, but all patients who died without regaining consciousness had increased cerebral blood flow that appeared within 24 hours after resuscitation (except in one patient in whom the first measurement was delayed until 28 hours after resuscitation, by which time cerebral blood flow was increased). The cause of the delayed-onset increase in cerebral blood flow is not known, but the increase may have adverse effects on brain function and may indicate the onset of irreversible brain damage.

  18. Deriving Macropore and Preferential Flow Parameters from Tracer and Time-lapse 3D GPR Experiments at the Plot-Scale

    NASA Astrophysics Data System (ADS)

    Jackisch, Conrad; Allroggen, Niklas; Tronicke, Jens; Zehe, Erwin

    2014-05-01

    "Hydrology - a science in which all processes are preferential" (Uhlenbrook, 2006) - as such preferential flow is known and discussed in hydrology since almost three decades. At the same time, preferential flow remains problematic as explicit descriptions are hard to define and upscale and implicit descriptions remain rather case sensitive. Moreover, our techniques to monitor preferential flow and especially flow structures are very limited. We conducted three multi-tracer plot-scale (1m x 1m) sprinkler experiments at a forested hillslope in the Attert Basin in Luxembourg with prevailing geogenic and biogenic preferential flow structures. It was accompanied by a 3D time-lapse GPR (Ground Penetrating Radar) survey covering an area of 3m x 3m. We present the results with special emphasis on the derivation of macropore parameters for further modelling. To do so, we developed an automated analysis of images from excavated Brilliant Blue stained profiles. Additionally, we analyse our time-lapse GPR data with respect to temporal changes and derive 3D strutural information of the preferential flow patterns. Superior to tracers, this high resolution subsurface imaging technique is non-invasive, repeatable and therefore helps to disentangle the dye stained patterns towards process observation. The results of the image analyses and the GPR surveys are compared and referenced to soil moisture monitoring, sampled Bromide profiles and stable isotope signatures. We further discuss implications for joint development of model concepts and observation methods.

  19. Effects of vasoactive stimuli on blood flow to choroid plexus

    SciTech Connect

    Faraci, F.M.; Mayhan, W.G.; Williams, J.K.; Heistad, D.D. )

    1988-02-01

    The goal of this study was to examine effects of vasoactive stimuli on blood flow to choroid plexus. The authors used microspheres to measure blood flow to choroid plexus and cerebrum in anesthetized dogs and rabbits. A critical assumption of the microsphere method is that microspheres do not pass through arteriovenous shunts. Blood flow values obtained with simultaneous injection of 15- and 50-{mu}m microspheres were similar, which suggest that shunting of 15-{mu}m microspheres was minimal. Blood flow to choroid plexus under control conditions was 287 {plus minus} 26 (means {plus minus} SE) ml {center dot} min{sup {minus}1} {center dot} 100 g{sup {minus}1} in dogs and 385 {plus minus} 73 ml {center dot} min{sup {minus}1} 100 g{sup {minus}1} in rabbits. Consecutive measurements under control conditions indicated that values for blood flow are reproducible. Adenosine did not alter blood flow to cerebrum but increased blood flow to choroid plexus two- to threefold in dogs and rabbits. Norepinephrine and phenylephrine did not affect blood flow to choroid plexus and cerebrum but decreased blood flow to choroid plexus by {approx} 50%. The authors suggest that (1) the microsphere method provides reproducible valid measurements of blood flow to the choroid plexus in dogs and rabbits and (2) vasoactive stimuli may have profoundly different effects on blood flow to choroid plexus and cerebrum.

  20. Diffuse optical correlation tomography of cerebral blood flow during cortical spreading depression in rat brain

    NASA Astrophysics Data System (ADS)

    Zhou, Chao; Yu, Guoqiang; Furuya, Daisuke; Greenberg, Joel; Yodh, Arjun; Durduran, Turgut

    2006-02-01

    Diffuse optical correlation methods were adapted for three-dimensional (3D) tomography of cerebral blood flow (CBF) in small animal models. The image reconstruction was optimized using a noise model for diffuse correlation tomography which enabled better data selection and regularization. The tomographic approach was demonstrated with simulated data and during in-vivo cortical spreading depression (CSD) in rat brain. Three-dimensional images of CBF were obtained through intact skull in tissues(~4mm) deep below the cortex.

  1. Quantification of anthropogenic impact on groundwater dependent terrestrial ecosystem using geochemical and isotope tools combined with 3-D flow and transport modeling

    NASA Astrophysics Data System (ADS)

    Zurek, A. J.; Witczak, S.; Dulinski, M.; Wachniew, P.; Rozanski, K.; Kania, J.; Postawa, A.; Karczewski, J.; Moscicki, W. J.

    2014-08-01

    A dedicated study was launched in 2010 with the main aim to better understand the functioning of groundwater dependent terrestrial ecosystem (GDTE) located in southern Poland. The GDTE consists of a valuable forest stand (Niepolomice Forest) and associated wetland (Wielkie Bloto fen). A wide range of tools (environmental tracers, geochemistry, geophysics, 3-D flow and transport modeling) was used. The research was conducted along three major directions: (i) quantification of the dynamics of groundwater flow in various parts of the aquifer associated with GDTE, (ii) quantification of the degree of interaction between the GDTE and the aquifer, and (iii) 3-D modeling of groundwater flow in the vicinity of the studied GDTE and quantification of possible impact of enhanced exploitation of the aquifer on the status of GDTE. Environmental tracer data (tritium, stable isotopes of water) strongly suggest that upward leakage of the aquifer contributes significantly to the present water balance of the studied wetland and associated forest. Physico-chemical parameters of water (pH, conductivity, Na / Cl ratio) confirm this notion. Model runs indicate that prolonged groundwater abstraction through the newly-established network of water supply wells, conducted at maximum permitted capacity (ca. 10 000 m3 d-1), may trigger drastic changes in the ecosystem functioning, eventually leading to its degradation.

  2. 3D numerical modeling of mantle flow, crustal dynamics and magma genesis associated with slab roll-back and tearing: The eastern Mediterranean case

    NASA Astrophysics Data System (ADS)

    Menant, Armel; Sternai, Pietro; Jolivet, Laurent; Guillou-Frottier, Laurent; Gerya, Taras

    2016-05-01

    Interactions between subduction dynamics and magma genesis have been intensely investigated, resulting in several conceptual models derived from geological, geochemical and geophysical data. To provide physico-chemical constraints on these conceptual models, self-consistent numerical simulations containing testable thermo-mechanical parameters are required, especially considering the three-dimensional (3D) natural complexity of subduction systems. Here, we use a 3D high-resolution petrological and thermo-mechanical numerical model to quantify the relative contribution of oceanic and continental subduction/collision, slab roll-back and tearing to magma genesis and transport processes. Our modeling results suggest that the space and time distribution and composition of magmas in the overriding plate is controlled by the 3D slab dynamics and related asthenospheric flow. Moreover, the decrease of the bulk lithospheric strength induced by mantle- and crust-derived magmas promotes the propagation of strike-slip and extensional fault zones through the overriding crust as response to slab roll-back and continental collision. Reduction of the lithosphere/asthenosphere rheological contrast by lithospheric weakening also favors the transmission of velocities from the flowing mantle to the crust. Similarities between our modeling results and the late Cenozoic tectonic and magmatic evolution across the eastern Mediterranean region suggest an efficient control of mantle flow on the magmatic activity in this region, which in turn promotes lithospheric deformation by mantle drag via melt-induced weakening effects.

  3. Heat transfer analysis for peripheral blood flow measurement system

    NASA Astrophysics Data System (ADS)

    Nagata, Koji; Hattori, Hideharu; Sato, Nobuhiko; Ichige, Yukiko; Kiguchi, Masashi

    2009-06-01

    Some disorders such as circulatory disease and metabolic abnormality cause many problems to peripheral blood flow condition. Therefore, frequent measurement of the blood flow condition is bound to contribute to precaution against those disorders and to control of conditions of the diseases. We propose a convenient means of blood flow volume measurement at peripheral part, such as fingertips. Principle of this measurement is based on heat transfer characteristics of peripheral part containing the blood flow. Transition response analysis of skin surface temperature has provided measurement model of the peripheral blood flow volume. We developed the blood flow measurement system based on that model and evaluated it by using artificial finger under various temperature conditions of ambience and internal fluid. The evaluation results indicated that proposed method could estimate the volume of the fluid regardless of temperature condition of them. Finally we applied our system to real finger testing and have obtained results correlated well with laser Doppler blood flow meter values.

  4. Cerebral blood flow tomography with xenon-133

    SciTech Connect

    Lassen, N.A.

    1985-10-01

    Cerebral blood flow (CBF) can be measured tomographically by inhalation of Xenon-/sup 133/. The calculation is based on taking a sequence of tomograms during the wash-in and wash-out phase of the tracer. Due to the dynamic nature of the process, a highly sensitive and fast moving single photon emission computed tomograph (SPECT) is required. Two brain-dedicated SPECT systems designed for this purpose are mentioned, and the method is described with special reference to the limitations inherent in the soft energy of the 133Xe primary photons. CBF tomography can be used for a multitude of clinical and investigative purposes. This article discusses in particular its use for the selection of patients with carotid occlusion for extracranial/intracranial bypass surgery, for detection of severe arterial spasm after aneurysm bleeding, and for detection of low flow areas during severe migraine attacks. The use of other tracers for CBF tomography using SPECT is summarized with emphasis on the /sup 99m/Tc chelates that freely pass the intact blood-brain barrier. The highly sensitive brain-dedicated SPECT systems described are a prerequisite for achieving high resolution tomograms with such tracers.

  5. Tissue blood flow mapping using laser technology

    NASA Astrophysics Data System (ADS)

    Wardell, Karin; Linden, Maria; Nilsson, Gert E.

    1995-03-01

    By the introduction of the laser Doppler perfusion imager (LDPI) the microvascular blood flow in a tissue area can be mapped by sequentially moving a laser beam over the tissue. The measurement is performed without touching the tissue and the captured perfusion values in the peripheral circulation are presented as a color-coded image. In the ordinary LDPI-set-up, 64 X 64 measurement sites cover an area in the range of about 10 - 150 cm2 depending on system settings. With a high resolution modification, recordings can be done on tissue areas as small as 1 cm2. This high resolution option has been assessed in animal models for the mapping of small vessels. To be able to record not only spatial but also temporal perfusion components of tissue blood flow, different local area scans (LAS) have been developed. These include single point recording as well as integration of either 2 X 2, 3 X 3, or 4 X 4 measurement sites. The laser beam is repeatedly moved in a quadratic pattern over the small tissue area of interest and the output value constitutes the average perfusion of all captured values within the actual region. For the evaluation, recordings were performed on healthy volunteers before and after application of a vasodilatating cream on the dorsal side of the hand.

  6. 3-D numerical models of viscous flow applied to fold nappes and the Rawil depression in the Helvetic nappe system (western Switzerland)

    NASA Astrophysics Data System (ADS)

    von Tscharner, M.; Schmalholz, S. M.; Epard, J.-L.

    2016-05-01

    The Helvetic nappe system exhibits three-dimensional (3-D) features such as the lateral variation in geometry between the Morcles and Doldenhorn fold nappes or the Rawil depression. We perform 3-D finite element simulations of linear and power-law viscous flow to investigate fold nappe formation during shortening of a half graben with laterally varying thickness. 3-D ellipsoids and corresponding 2-D intersection ellipses are used to quantify finite strain. Fold nappes which formed above a thicker graben have (i) larger amplitudes, (ii) a less sheared and thinned overturned limb, and (iii) a larger thickness than fold nappes formed above a thinner graben. These results agree with observations for the Morcles and Doldenhorn nappes. We also perform 3-D simulations for a tectonic scenario suggested for the evolution of the Rawil depression. The basement is shortened and extended laterally and includes a graben which is oblique to the shortening direction and acts as mechanical weak zone. The graben causes laterally varying basement uplift generating a depression whose amplitude depends on the graben orientation and the stress exponent of basement and sediments. The axial plunge of the depression is smaller (approximately 10°) than the observed plunge (approximately 30°) indicating that additional processes are required to explain the geometry of the Rawil depression.

  7. Effectiveness of evaluating tumor vascularization using 3D power Doppler ultrasound with high-definition flow technology in the prediction of the response to neoadjuvant chemotherapy for T2 breast cancer: a preliminary report

    NASA Astrophysics Data System (ADS)

    Shia, Wei-Chung; Chen, Dar-Ren; Huang, Yu-Len; Wu, Hwa-Koon; Kuo, Shou-Jen

    2015-10-01

    The aim of this study was to evaluate the effectiveness of advanced ultrasound (US) imaging of vascular flow and morphological features in the prediction of a pathologic complete response (pCR) and a partial response (PR) to neoadjuvant chemotherapy for T2 breast cancer. Twenty-nine consecutive patients with T2 breast cancer treated with six courses of anthracycline-based neoadjuvant chemotherapy were enrolled. Three-dimensional (3D) power Doppler US with high-definition flow (HDF) technology was used to investigate the blood flow in and morphological features of the tumors. Six vascularity quantization features, three morphological features, and two vascular direction features were selected and extracted from the US images. A support vector machine was used to evaluate the changes in vascularity after neoadjuvant chemotherapy, and pCR and PR were predicted on the basis of these changes. The most accurate prediction of pCR was achieved after the first chemotherapy cycle, with an accuracy of 93.1% and a specificity of 85.5%, while that of a PR was achieved after the second cycle, with an accuracy of 79.31% and a specificity of 72.22%. Vascularity data can be useful to predict the effects of neoadjuvant chemotherapy. Determination of changes in vascularity after neoadjuvant chemotherapy using 3D power Doppler US with HDF can generate accurate predictions of the patient response, facilitating early decision-making.

  8. A New Computational Tool for Simulation of 3-D Flow and Heat Transfer in Boiling Water Reactors

    SciTech Connect

    Chen, Hudong

    2002-12-09

    This Phase I work has developed a novel hybrid Lattice Boltzmann Model for the simulation of nonideal fluid thermal dynamics and demonstrated that this model can be used to simulate fundamental two-phase flow processes including boiling initiation, bubble formation and coalescency, and flow-regime formation.

  9. High-speed flow calculations past 3-D configurations based on the Reynolds averaged Navier-Stokes equations

    NASA Technical Reports Server (NTRS)

    Chaussee, Denny S.

    1988-01-01

    A computational fluid dynamics tool has been developed capable of analyzing the viscous supersonic/hypersonic flow about realistic configurations. This techniques can predict the flow in regions of canopies, wings, and canards in addition to the usual simple symmetric configurations. It also allows for interactions between aerodynamic surfaces such as the vortex interaction between canards and wings.

  10. Advanced 3D mesh manipulation in stereolithographic files and post-print processing for the manufacturing of patient-specific vascular flow phantoms

    NASA Astrophysics Data System (ADS)

    O'Hara, Ryan P.; Chand, Arpita; Vidiyala, Sowmya; Arechavala, Stacie M.; Mitsouras, Dimitrios; Rudin, Stephen; Ionita, Ciprian N.

    2016-03-01

    Complex vascular anatomies can cause the failure of image-guided endovascular procedures. 3D printed patient-specific vascular phantoms provide clinicians and medical device companies the ability to preemptively plan surgical treatments, test the likelihood of device success, and determine potential operative setbacks. This research aims to present advanced mesh manipulation techniques of stereolithographic (STL) files segmented from medical imaging and post-print surface optimization to match physiological vascular flow resistance. For phantom design, we developed three mesh manipulation techniques. The first method allows outlet 3D mesh manipulations to merge superfluous vessels into a single junction, decreasing the number of flow outlets and making it feasible to include smaller vessels. Next we introduced Boolean operations to eliminate the need to manually merge mesh layers and eliminate errors of mesh self-intersections that previously occurred. Finally we optimize support addition to preserve the patient anatomical geometry. For post-print surface optimization, we investigated various solutions and methods to remove support material and smooth the inner vessel surface. Solutions of chloroform, alcohol and sodium hydroxide were used to process various phantoms and hydraulic resistance was measured and compared with values reported in literature. The newly mesh manipulation methods decrease the phantom design time by 30 - 80% and allow for rapid development of accurate vascular models. We have created 3D printed vascular models with vessel diameters less than 0.5 mm. The methods presented in this work could lead to shorter design time for patient specific phantoms and better physiological simulations.

  11. Modified Beer-Lambert law for blood flow.

    PubMed

    Baker, Wesley B; Parthasarathy, Ashwin B; Busch, David R; Mesquita, Rickson C; Greenberg, Joel H; Yodh, A G

    2014-11-01

    We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues. PMID:25426330

  12. Modified Beer-Lambert law for blood flow

    PubMed Central

    Baker, Wesley B.; Parthasarathy, Ashwin B.; Busch, David R.; Mesquita, Rickson C.; Greenberg, Joel H.; Yodh, A. G.

    2014-01-01

    We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues. PMID:25426330

  13. Modified Beer-Lambert law for blood flow.

    PubMed

    Baker, Wesley B; Parthasarathy, Ashwin B; Busch, David R; Mesquita, Rickson C; Greenberg, Joel H; Yodh, A G

    2014-11-01

    We develop and validate a Modified Beer-Lambert law for blood flow based on diffuse correlation spectroscopy (DCS) measurements. The new formulation enables blood flow monitoring from temporal intensity autocorrelation function data taken at single or multiple delay-times. Consequentially, the speed of the optical blood flow measurement can be substantially increased. The scheme facilitates blood flow monitoring of highly scattering tissues in geometries wherein light propagation is diffusive or non-diffusive, and it is particularly well-suited for utilization with pressure measurement paradigms that employ differential flow signals to reduce contributions of superficial tissues.

  14. Numerical simulation of heat transfer and flow structure in 3-D turbulent boundary layer with imbedded longitudinal vortex

    SciTech Connect

    Jeong, J.Y.; Ryou, H.S.

    1997-03-01

    Heat transfer characteristics and flow structure in turbulent flows through a flat plate three-dimensional turbulent boundary layer containing built-in vortex generators have been analyzed by means of the space marching Crank-Nicolson finite difference method. The method solves the slender flow approximation of the steady three-dimensional Navier-Stokes and energy equations. This study used the eddy diffusivity model and standard {kappa}-{epsilon} model to predict heat transfer and flow field in the turbulent flow with imbedded longitudinal vortex. The results show boundary layer distortion due to vortices, such as strong spanwise flow divergence and boundary layer thinning. The heat transfer and skin friction show relatively good results in comparison with experimental data. The vortex core moves slightly away from the wall and grows slowly; consequently, the vortex influences the flow over a very long distance downstream. The enhancement of the heat transfer in the vicinity of the wall is due to the increasing spanwise separation of the vortices as they develop in the streamwise direction.

  15. Topical menthol increases cutaneous blood flow.

    PubMed

    Craighead, Daniel H; Alexander, Lacy M

    2016-09-01

    Menthol, the active ingredient in several topically applied analgesics, activates transient receptor potential melastatin 8 (TRPM8) receptors on sensory nerves and on the vasculature inducing a cooling sensation on the skin. Ilex paraguariensis is also a common ingredient in topical analgesics that has potential vasoactive properties and may alter the mechanisms of action of menthol. We sought to characterize the microvascular effects of topical menthol and ilex application and to determine the mechanism(s) through which these compounds may independently and combined alter cutaneous blood flow. We hypothesized that menthol would induce vasoconstriction and that ilex would not alter skin blood flow (SkBF). Three separate protocols were conducted to examine menthol and ilex-mediated changes in SkBF. In protocol 1, placebo, 4% menthol, 0.7% ilex, and combination menthol+ilex gels were applied separately to the skin and red cell flux was continuously measured utilizing laser speckle contrast imaging (LSCI). In protocol 2, seven concentrations of menthol gel (0.04%, 0.4%, 1%, 2%, 4%, 7%, 8%) were applied to the skin to model the dose-response curve. In protocol 3, placebo, menthol, ilex, and menthol+ilex gels were applied to skin under local thermal control (34°C) both with and without sensory nerve blockage (topical lidocaine 4%). Post-occlusive reactive hyperemia (PORH) and local heating (42°C) protocols were conducted to determine the relative contribution of endothelium derived hyperpolarizing factors (EDHFs)/sensory nerves and nitric oxide (NO), respectively. Red cell flux was normalized to mean arterial pressure expressed as cutaneous vascular conductance (CVC: flux·mmHg(-1)) in all protocols. Topical menthol application increased SkBF compared to placebo (3.41±0.33 vs 1.1±0.19CVC: p<0.001). During the dose-response, SkBF increased with increasing doses of menthol (main effect, p<0.05) with an ED50 of 1.0%. Similarly, SkBF was increased after menthol

  16. Laser Speckle Imaging of Cerebral Blood Flow

    NASA Astrophysics Data System (ADS)

    Luo, Qingming; Jiang, Chao; Li, Pengcheng; Cheng, Haiying; Wang, Zhen; Wang, Zheng; Tuchin, Valery V.

    Monitoring the spatio-temporal characteristics of cerebral blood flow (CBF) is crucial for studying the normal and pathophysiologic conditions of brain metabolism. By illuminating the cortex with laser light and imaging the resulting speckle pattern, relative CBF images with tens of microns spatial and millisecond temporal resolution can be obtained. In