Science.gov

Sample records for 3d kinematic study

  1. A 3D kinematic study of the northern ejecta `jet' of the Crab nebula

    NASA Astrophysics Data System (ADS)

    Black, Christine S.; Fesen, Robert A.

    2015-03-01

    We present moderate resolution [O III] λλ4959, 5007 line emission spectra of the Crab nebula's northern ejecta jet. These data along with an [O III] image of the Crab nebula were used to build three-dimensional kinematic maps of the jet and adjacent remnant nebulosity to better understand the jet's properties and thus its likely origin. We find the jet's systemic velocity to be +170 ± 15 km s-1 with radial velocities ranging from -190 to +480 km s-1. Our data indicate that the jet consists of thin filamentary walls (Vexp ≃ 40-75 km s-1), is virtually hollow in [O III] emission, and elliptical and funnel-like in shape rather than a straight cylindrical tube as previously thought. Examination of the Crab's 3D filamentary structure along the jet's base reveals a large and nearly emission-free opening in the remnant's thick outer ejecta shell. The jet's blueshifted and redshifted sides are surprisingly well defined and, like the jet's sharp western limb, appear radially aligned with the remnant's centre of expansion. These alignments, along with the opening in the nebula at the jet's base and proper motions indicating an expansion age in line with the 1054 supernova event, suggest a direct connection between the jet's formation and the Crab's radial expansion. While our analysis supports the scenario that the jet may simply represent the highest velocity material of the remnant's N-S bipolar expansion, the nature of this expansion asymmetry remains unclear.

  2. A 2D 3D registration with low dose radiographic system for in vivo kinematic studies.

    PubMed

    Jerbi, T; Burdin, V; Stindel, E; Roux, C

    2011-01-01

    The knowledge of the poses and the positions of the knee bones and prostheses is of a great interest in the orthopedic and biomechanical applications. In this context, we use an ultra low dose bi-planar radiographic system called EOS to acquire two radiographs of the studied bones in each position. In this paper, we develop a new method for 2D 3D registration based on the frequency domain to determine the poses and the positions during quasi static motion analysis for healthy and prosthetic knees. Data of two healthy knees and four knees with unicompartimental prosthesis performing three different poses (full extension, 30° and 60° of flexion) were used in this work. The results we obtained are in concordance with the clinical accuracy and with the accuracy reported in other previous studies.

  3. Study of human body: Kinematics and kinetics of a martial arts (Silat) performers using 3D-motion capture

    NASA Astrophysics Data System (ADS)

    Soh, Ahmad Afiq Sabqi Awang; Jafri, Mohd Zubir Mat; Azraai, Nur Zaidi

    2015-04-01

    The Interest in this studies of human kinematics goes back very far in human history drove by curiosity or need for the understanding the complexity of human body motion. To find new and accurate information about the human movement as the advance computing technology became available for human movement that can perform. Martial arts (silat) were chose and multiple type of movement was studied. This project has done by using cutting-edge technology which is 3D motion capture to characterize and to measure the motion done by the performers of martial arts (silat). The camera will detect the markers (infrared reflection by the marker) around the performer body (total of 24 markers) and will show as dot in the computer software. The markers detected were analyzing using kinematic kinetic approach and time as reference. A graph of velocity, acceleration and position at time,t (seconds) of each marker was plot. Then from the information obtain, more parameters were determined such as work done, momentum, center of mass of a body using mathematical approach. This data can be used for development of the effectiveness movement in martial arts which is contributed to the people in arts. More future works can be implemented from this project such as analysis of a martial arts competition.

  4. Stumbling reactions during perturbed walking: Neuromuscular reflex activity and 3-D kinematics of the trunk - A pilot study.

    PubMed

    Müller, Juliane; Müller, Steffen; Engel, Tilman; Reschke, Antje; Baur, Heiner; Mayer, Frank

    2016-04-11

    Reflex activity of the lower leg muscles involved when compensating for falls has already been thoroughly investigated. However, the trunk׳s role in this compensation strategy remains unclear. The purpose of this study, therefore, was to analyze the kinematics and muscle activity of the trunk during perturbed walking. Ten subjects (29 ± 3 yr;79 ± 11 cm;74 ± 14 kg) walked (1m/s) on a split-belt treadmill, while 5 randomly timed, right-sided perturbations (treadmill belt deceleration: 40 m/s(2)) were applied. Trunk muscle activity was assessed with a 12-lead-EMG. Trunk kinematics were measured with a 3D-motion analysis system (12 markers framing 3 segments: upper thoracic area (UTA), lower thoracic area (LTA), lumbar area (LA)). The EMG-RMS [%] (0-200 ms after perturbation) was analyzed and then normalized to the RMS of normal walking. The total range of motion (ROM;[°]) for the extension/flexion, lateral flexion and rotation of each segment were calculated. Individual kinematic differences between walking and stumbling [%; ROM] were also computed. Data analysis was conducted descriptively, followed by one- and two-way ANOVAs (α=0.05). Stumbling led to an increase in ROM, compared to unperturbed gait, in all segments and planes. These increases ranged between 107 ± 26% (UTA/rotation) and 262 ± 132% (UTS/lateral flexion), significant only in lateral flexion. EMG activity of the trunk was increased during stumbling (abdominal: 665 ± 283%; back: 501 ± 215%), without significant differences between muscles. Provoked stumbling leads to a measurable effect on the trunk, quantifiable by an increase in ROM and EMG activity, compared to normal walking. Greater abdominal muscle activity and ROM of lateral flexion may indicate a specific compensation pattern occurring during stumbling.

  5. In vivo kinematic study of the tarsal joints complex based on fluoroscopic 3D-2D registration technique.

    PubMed

    Chen Wang, M D; Geng, Xiang; Wang, Shaobai; Xin Ma, M D; Xu Wang, M D; Jiazhang Huang, M D; Chao Zhang, M D; Li Chen, M S; Yang, Junsheng; Wang, Kan

    2016-09-01

    The tarsal bones articulate with each other and demonstrate complicated kinematic characteristics. The in vivo motions of these tarsal joints during normal gait are still unclear. Seven healthy subjects were recruited and fourteen feet in total were tested in the current study. Three dimensional models of the tarsal bones were first created using CT scanning. Corresponding local 3D coordinate systems of each tarsal bone was subsequently established for 6DOF motion decompositions. The fluoroscopy system captured the lateral fluoroscopic images of the targeted tarsal region whilst the subject was walking. Seven key pose images during the stance phase were selected and 3D to 2D bone model registrations were performed on each image to determine joint positions. The 6DOF motions of each tarsal joint during gait were then obtained by connecting these positions together. The TNJ (talo-navicular joint) exhibited the largest ROMs (range of motion) on all rotational directions with 7.39±2.75°of dorsi/plantarflexion, 21.12±4.68°of inversion/eversion, and 16.11±4.44°of internal/external rotation. From heel strike to midstance, the TNJ, STJ (subtalar joint), and CCJ (calcaneao-cuboid joint) were associated with 5.97°, 5.04°, and 3.93°of dorsiflexion; 15.46°, 8.21°, and 5.82°of eversion; and 9.75°, 7.6°, and 4.99°of external rotation, respectively. Likewise, from midstance to heel off, the TNJ, STJ, and CCJ were associated with 6.39, 6.19°, and 4.47°of plantarflexion; 18.57°, 11.86°, and 6.32°of inversion and 13.95°, 9.66°, and 7.58°of internal rotation, respectively. In conclusion, among the tarsal joints, the TNJ exhibited the greatest rotational mobility. Synchronous and homodromous rotational motions were detected for TNJ, STJ, and CCJ during the stance phase.

  6. Measuring the Stellar Halo Velocity Anisotropy With 3D Kinematics

    NASA Astrophysics Data System (ADS)

    Cunningham, Emily C.; Deason, Alis J.; Guhathakurta, Puragra; Rockosi, Constance M.; van der Marel, Roeland P.; Sohn, S. Tony

    2016-08-01

    We present the first measurement of the anisotropy parameter β using 3D kinematic information outside of the solar neighborhood. Our sample consists of 13 Milky Way halo stars with measured proper motions and radial velocities in the line of sight of M31. Proper motions were measured using deep, multi-epoch HST imaging, and radial velocities were measured from Keck II/DEIMOS spectra. We measure β = -0.3-0.9 +0.4, which is consistent with isotropy, and inconsistent with measurements in the solar neighborhood. We suggest that this may be the kinematic signature of a relatively early, massive accretion event, or perhaps several such events.

  7. Kinematics and flow fields in 3D around swimming lamprey using light field PIV

    NASA Astrophysics Data System (ADS)

    Lehn, Andrea M.; Techet, Alexandra H.

    2016-11-01

    The fully time-resolved 3D kinematics and flow field velocities around freely swimming sea lamprey are derived using 3D light field imaging PIV. Lighthill's Elongated Body Theory (EBT) predicts that swimmers with anguilliform kinematics likened to lamprey, and similarly eels, will exhibit relatively poor propulsive efficiency. However, previous experimental studies of eel locomotion utilizing 2D PIV suggest disagreement with EBT estimates of wake properties; although, the thrust force generated by such swimmers has yet to be fully resolved using 3D measurements. A light field imaging array of multiple high-speed cameras is used to perform 3D synthetic aperture PIV around ammocoete sea lamprey (Petromyzon marinus). Fluid mechanics equations are used to determine thrust force generation, leading experimental studies closer to underpinning the physical mechanisms that enable aquatic locomotion of long, slender undulatory swimmers.

  8. Accurate 3D kinematic measurement of temporomandibular joint using X-ray fluoroscopic images

    NASA Astrophysics Data System (ADS)

    Yamazaki, Takaharu; Matsumoto, Akiko; Sugamoto, Kazuomi; Matsumoto, Ken; Kakimoto, Naoya; Yura, Yoshiaki

    2014-04-01

    Accurate measurement and analysis of 3D kinematics of temporomandibular joint (TMJ) is very important for assisting clinical diagnosis and treatment of prosthodontics and orthodontics, and oral surgery. This study presents a new 3D kinematic measurement technique of the TMJ using X-ray fluoroscopic images, which can easily obtain the TMJ kinematic data in natural motion. In vivo kinematics of the TMJ (maxilla and mandibular bone) is determined using a feature-based 2D/3D registration, which uses beads silhouette on fluoroscopic images and 3D surface bone models with beads. The 3D surface models of maxilla and mandibular bone with beads were created from CT scans data of the subject using the mouthpiece with the seven strategically placed beads. In order to validate the accuracy of pose estimation for the maxilla and mandibular bone, computer simulation test was performed using five patterns of synthetic tantalum beads silhouette images. In the clinical applications, dynamic movement during jaw opening and closing was conducted, and the relative pose of the mandibular bone with respect to the maxilla bone was determined. The results of computer simulation test showed that the root mean square errors were sufficiently smaller than 1.0 mm and 1.0 degree. In the results of clinical application, during jaw opening from 0.0 to 36.8 degree of rotation, mandibular condyle exhibited 19.8 mm of anterior sliding relative to maxillary articular fossa, and these measurement values were clinically similar to the previous reports. Consequently, present technique was thought to be suitable for the 3D TMJ kinematic analysis.

  9. Market study: 3-D eyetracker

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A market study of a proposed version of a 3-D eyetracker for initial use at NASA's Ames Research Center was made. The commercialization potential of a simplified, less expensive 3-D eyetracker was ascertained. Primary focus on present and potential users of eyetrackers, as well as present and potential manufacturers has provided an effective means of analyzing the prospects for commercialization.

  10. Numerical model of sonic boom in 3D kinematic turbulence

    NASA Astrophysics Data System (ADS)

    Coulouvrat, François; Luquet, David; Marchiano, Régis

    2015-10-01

    Sonic boom is one of the key issues to be considered in the development of future supersonic or hypersonic civil aircraft concepts. The classical sonic boom, typical for Concorde with an N-wave shape and a ground amplitude of the order of 100 Pa, prevents overland flight. Future concepts target carefully shaped sonic booms with low amplitude weak shocks. However, sonic boom when perceived at the ground level is influenced not only by the aircraft characteristics, but also by atmospheric propagation. In particular, the effect of atmospheric turbulence on sonic boom propagation near the ground is not well characterized. Flight tests performed as early as the 1960s demonstrated that classical sonic booms are sensitive to atmospheric turbulence. However, this sensitivity remains only partially understood. This is related to the fact that i) turbulence is a random process that requires a statistical approach, ii) standard methods used to predict sonic booms, mainly geometrical acoustics based on ray tracing, are inadequate within the turbulent planetary boundary layer. Moreover, the ray theory fails to predict the acoustical field in many areas of interest, such as caustics or shadow zones. These zones are of major interest for sonic boom acceptability (highest levels, lateral extent of zone of impact). These limitations outline the need for a numerical approach that is sufficiently efficient to perform a large number of realizations for a statistical approach, but that goes beyond the limitations of ray theory. With this in view, a 3D one-way numerical method solving a nonlinear scalar wave equation established for heterogeneous, moving and absorbing atmosphere, is used to assess the effects of a 3D kinematic turbulence on sonic boom in various configurations. First, a plane N-wave is propagated in the free field through random realizations of kinematic fluctuations. Then the case of a more realistic Atmospheric Boundary Layer (ABL) is investigated, with a mean

  11. Bore-Sight Calibration of Multiple Laser Range Finders for Kinematic 3D Laser Scanning Systems.

    PubMed

    Jung, Jaehoon; Kim, Jeonghyun; Yoon, Sanghyun; Kim, Sangmin; Cho, Hyoungsig; Kim, Changjae; Heo, Joon

    2015-05-04

    The Simultaneous Localization and Mapping (SLAM) technique has been used for autonomous navigation of mobile systems; now, its applications have been extended to 3D data acquisition of indoor environments. In order to reconstruct 3D scenes of indoor space, the kinematic 3D laser scanning system, developed herein, carries three laser range finders (LRFs): one is mounted horizontally for system-position correction and the other two are mounted vertically to collect 3D point-cloud data of the surrounding environment along the system's trajectory. However, the kinematic laser scanning results can be impaired by errors resulting from sensor misalignment. In the present study, the bore-sight calibration of multiple LRF sensors was performed using a specially designed double-deck calibration facility, which is composed of two half-circle-shaped aluminum frames. Moreover, in order to automatically achieve point-to-point correspondences between a scan point and the target center, a V-shaped target was designed as well. The bore-sight calibration parameters were estimated by a constrained least squares method, which iteratively minimizes the weighted sum of squares of residuals while constraining some highly-correlated parameters. The calibration performance was analyzed by means of a correlation matrix. After calibration, the visual inspection of mapped data and residual calculation confirmed the effectiveness of the proposed calibration approach.

  12. Bore-Sight Calibration of Multiple Laser Range Finders for Kinematic 3D Laser Scanning Systems

    PubMed Central

    Jung, Jaehoon; Kim, Jeonghyun; Yoon, Sanghyun; Kim, Sangmin; Cho, Hyoungsig; Kim, Changjae; Heo, Joon

    2015-01-01

    The Simultaneous Localization and Mapping (SLAM) technique has been used for autonomous navigation of mobile systems; now, its applications have been extended to 3D data acquisition of indoor environments. In order to reconstruct 3D scenes of indoor space, the kinematic 3D laser scanning system, developed herein, carries three laser range finders (LRFs): one is mounted horizontally for system-position correction and the other two are mounted vertically to collect 3D point-cloud data of the surrounding environment along the system’s trajectory. However, the kinematic laser scanning results can be impaired by errors resulting from sensor misalignment. In the present study, the bore-sight calibration of multiple LRF sensors was performed using a specially designed double-deck calibration facility, which is composed of two half-circle-shaped aluminum frames. Moreover, in order to automatically achieve point-to-point correspondences between a scan point and the target center, a V-shaped target was designed as well. The bore-sight calibration parameters were estimated by a constrained least squares method, which iteratively minimizes the weighted sum of squares of residuals while constraining some highly-correlated parameters. The calibration performance was analyzed by means of a correlation matrix. After calibration, the visual inspection of mapped data and residual calculation confirmed the effectiveness of the proposed calibration approach. PMID:25946627

  13. Effect of Kayak Ergometer Elastic Tension on Upper Limb EMG Activity and 3D Kinematics.

    PubMed

    Fleming, Neil; Donne, Bernard; Fletcher, David

    2012-01-01

    Despite the prevalence of shoulder injury in kayakers, limited published research examining associated upper limb kinematics and recruitment patterns exists. Altered muscle recruitment patterns on-ergometer vs. on-water kayaking were recently reported, however, mechanisms underlying changes remain to be elucidated. The current study assessed the effect of ergometer recoil tension on upper limb recruitment and kinematics during the kayak stroke. Male kayakers (n = 10) performed 4 by 1 min on-ergometer exercise bouts at 85%VO2max at varying elastic recoil tension; EMG, stroke force and three-dimensional 3D kinematic data were recorded. While stationary recoil forces significantly increased across investigated tensions (125% increase, p < 0.001), no significant differences were detected in assessed force variables during the stroke cycle. In contrast, increasing tension induced significantly higher Anterior Deltoid (AD) activity in the latter stages (70 to 90%) of the cycle (p < 0.05). No significant differences were observed across tension levels for Triceps Brachii or Latissimus Dorsi. Kinematic analysis revealed that overhead arm movements accounted for 39 ± 16% of the cycle. Elbow angle at stroke cycle onset was 144 ± 10°; maximal elbow angle (151 ± 7°) occurred at 78 ± 10% into the cycle. All kinematic markers moved to a more anterior position as tension increased. No significant change in wrist marker elevation was observed, while elbow and shoulder marker elevations significantly increased across tension levels (p < 0.05). In conclusion, data suggested that kayakers maintained normal upper limb kinematics via additional AD recruitment despite ergometer induced recoil forces. Key pointsKayak ergometer elastic tension significantly alters Anterior Deltoid recruitment patterns.Kayakers maintain optimal arm kinematics despite changing external forces via altered shoulder muscle recruitment.Overhead arm movements account for a high proportion of the kayak

  14. Effect of Kayak Ergometer Elastic Tension on Upper Limb EMG Activity and 3D Kinematics

    PubMed Central

    Fleming, Neil; Donne, Bernard; Fletcher, David

    2012-01-01

    Despite the prevalence of shoulder injury in kayakers, limited published research examining associated upper limb kinematics and recruitment patterns exists. Altered muscle recruitment patterns on-ergometer vs. on-water kayaking were recently reported, however, mechanisms underlying changes remain to be elucidated. The current study assessed the effect of ergometer recoil tension on upper limb recruitment and kinematics during the kayak stroke. Male kayakers (n = 10) performed 4 by 1 min on-ergometer exercise bouts at 85%VO2max at varying elastic recoil tension; EMG, stroke force and three-dimensional 3D kinematic data were recorded. While stationary recoil forces significantly increased across investigated tensions (125% increase, p < 0.001), no significant differences were detected in assessed force variables during the stroke cycle. In contrast, increasing tension induced significantly higher Anterior Deltoid (AD) activity in the latter stages (70 to 90%) of the cycle (p < 0.05). No significant differences were observed across tension levels for Triceps Brachii or Latissimus Dorsi. Kinematic analysis revealed that overhead arm movements accounted for 39 ± 16% of the cycle. Elbow angle at stroke cycle onset was 144 ± 10°; maximal elbow angle (151 ± 7°) occurred at 78 ± 10% into the cycle. All kinematic markers moved to a more anterior position as tension increased. No significant change in wrist marker elevation was observed, while elbow and shoulder marker elevations significantly increased across tension levels (p < 0.05). In conclusion, data suggested that kayakers maintained normal upper limb kinematics via additional AD recruitment despite ergometer induced recoil forces. Key pointsKayak ergometer elastic tension significantly alters Anterior Deltoid recruitment patterns.Kayakers maintain optimal arm kinematics despite changing external forces via altered shoulder muscle recruitment.Overhead arm movements account for a high proportion of the kayak

  15. A Theoretical Study of the Build-up of the Sun’s Polar Magnetic Field by using a 3D Kinematic Dynamo Model

    NASA Astrophysics Data System (ADS)

    Hazra, Gopal; Choudhuri, Arnab Rai; Miesch, Mark S.

    2017-01-01

    We develop a three-dimensional kinematic self-sustaining model of the solar dynamo in which the poloidal field generation is from tilted bipolar sunspot pairs placed on the solar surface above regions of strong toroidal field by using the SpotMaker algorithm, and then the transport of this poloidal field to the tachocline is primarily caused by turbulent diffusion. We obtain a dipolar solution within a certain range of parameters. We use this model to study the build-up of the polar magnetic field and show that some insights obtained from surface flux transport models have to be revised. We present results obtained by putting a single bipolar sunspot pair in a hemisphere and two symmetrical sunspot pairs in two hemispheres. We find that the polar fields produced by them disappear due to the upward advection of poloidal flux at low latitudes, which emerges as oppositely signed radial flux and which is then advected poleward by the meridional flow. We also study the effect that a large sunspot pair, violating Hale’s polarity law, would have on the polar field. We find that there would be some effect—especially if the anti-Hale pair appears at high latitudes in the mid-phase of the cycle—though the effect is not very dramatic.

  16. The valuable use of Microsoft Kinect™ sensor 3D kinematic in the rehabilitation process in basketball

    NASA Astrophysics Data System (ADS)

    Braidot, Ariel; Favaretto, Guillermo; Frisoli, Melisa; Gemignani, Diego; Gumpel, Gustavo; Massuh, Roberto; Rayan, Josefina; Turin, Matías

    2016-04-01

    Subjects who practice sports either as professionals or amateurs, have a high incidence of knee injuries. There are a few publications that show studies from a kinematic point of view of lateral-structure-knee injuries, including meniscal (meniscal tears or chondral injury), without anterior cruciate ligament rupture. The use of standard motion capture systems for measuring outdoors sport is hard to implement due to many operative reasons. Recently released, the Microsoft Kinect™ is a sensor that was developed to track movements for gaming purposes and has seen an increased use in clinical applications. The fact that this device is a simple and portable tool allows the acquisition of data of sport common movements in the field. The development and testing of a set of protocols for 3D kinematic measurement using the Microsoft Kinect™ system is presented in this paper. The 3D kinematic evaluation algorithms were developed from information available and with the use of Microsoft’s Software Development Kit 1.8 (SDK). Along with this, an algorithm for calculating the lower limb joints angles was implemented. Thirty healthy adult volunteers were measured, using five different recording protocols for sport characteristic gestures which involve high knee injury risk in athletes.

  17. Reproducibility of 3D kinematics and surface electromyography measurements of mastication.

    PubMed

    Remijn, Lianne; Groen, Brenda E; Speyer, Renée; van Limbeek, Jacques; Nijhuis-van der Sanden, Maria W G

    2016-03-01

    The aim of this study was to determine the measurement reproducibility for a procedure evaluating the mastication process and to estimate the smallest detectable differences of 3D kinematic and surface electromyography (sEMG) variables. Kinematics of mandible movements and sEMG activity of the masticatory muscles were obtained over two sessions with four conditions: two food textures (biscuit and bread) of two sizes (small and large). Twelve healthy adults (mean age 29.1 years) completed the study. The second to the fifth chewing cycle of 5 bites were used for analyses. The reproducibility per outcome variable was calculated with an intraclass correlation coefficient (ICC) and a Bland-Altman analysis was applied to determine the standard error of measurement relative error of measurement and smallest detectable differences of all variables. ICCs ranged from 0.71 to 0.98 for all outcome variables. The outcome variables consisted of four bite and fourteen chewing cycle variables. The relative standard error of measurement of the bite variables was up to 17.3% for 'time-to-swallow', 'time-to-transport' and 'number of chewing cycles', but ranged from 31.5% to 57.0% for 'change of chewing side'. The relative standard error of measurement ranged from 4.1% to 24.7% for chewing cycle variables and was smaller for kinematic variables than sEMG variables. In general, measurements obtained with 3D kinematics and sEMG are reproducible techniques to assess the mastication process. The duration of the chewing cycle and frequency of chewing were the best reproducible measurements. Change of chewing side could not be reproduced. The published measurement error and smallest detectable differences will aid the interpretation of the results of future clinical studies using the same study variables.

  18. 3D Kinematics and Hydrodynamic Analysis of Freely Swimming Cetacean

    NASA Astrophysics Data System (ADS)

    Ren, Yan; Sheinberg, Dustin; Liu, Geng; Dong, Haibo; Fish, Frank; Javed, Joveria

    2015-11-01

    It's widely thought that flexibility and the ability to control flexibility are crucial elements in determining the performance of animal swimming. However, there is a lack of quantification of both span-wise and chord-wise deformation of Cetacean's flukes and associated hydrodynamic performance during actively swimming. To fill this gap, we examined the motion and flexure of both dolphin fluke and orca fluke in steady swimming using a combined experimental and computational approach. It is found that the fluke surface morphing can effectively modulate the flow structures and influence the propulsive performance. Findings from this work are fundamental for understanding key kinematic features of effective Cetacean propulsors, and for quantifying the hydrodynamic force production that naturally occurs during different types of swimming. This work is supported by ONR MURI N00014-14-1-0533 and NSF CBET-1313217.

  19. pynoddy 1.0: an experimental platform for automated 3-D kinematic and potential field modelling

    NASA Astrophysics Data System (ADS)

    Florian Wellmann, J.; Thiele, Sam T.; Lindsay, Mark D.; Jessell, Mark W.

    2016-03-01

    We present a novel methodology for performing experiments with subsurface structural models using a set of flexible and extensible Python modules. We utilize the ability of kinematic modelling techniques to describe major deformational, tectonic, and magmatic events at low computational cost to develop experiments testing the interactions between multiple kinematic events, effect of uncertainty regarding event timing, and kinematic properties. These tests are simple to implement and perform, as they are automated within the Python scripting language, allowing the encapsulation of entire kinematic experiments within high-level class definitions and fully reproducible results. In addition, we provide a link to geophysical potential-field simulations to evaluate the effect of parameter uncertainties on maps of gravity and magnetics. We provide relevant fundamental information on kinematic modelling and our implementation, and showcase the application of our novel methods to investigate the interaction of multiple tectonic events on a pre-defined stratigraphy, the effect of changing kinematic parameters on simulated geophysical potential fields, and the distribution of uncertain areas in a full 3-D kinematic model, based on estimated uncertainties in kinematic input parameters. Additional possibilities for linking kinematic modelling to subsequent process simulations are discussed, as well as additional aspects of future research. Our modules are freely available on github, including documentation and tutorial examples, and we encourage the contribution to this project.

  20. pynoddy 1.0: an experimental platform for automated 3-D kinematic and potential field modelling

    NASA Astrophysics Data System (ADS)

    Wellmann, J. F.; Thiele, S. T.; Lindsay, M. D.; Jessell, M. W.

    2015-11-01

    We present a novel methodology for performing experiments with subsurface structural models using a set of flexible and extensible Python modules. We utilise the ability of kinematic modelling techniques to describe major deformational, tectonic, and magmatic events at low computational cost to develop experiments testing the interactions between multiple kinematic events, effect of uncertainty regarding event timing, and kinematic properties. These tests are simple to implement and perform, as they are automated within the Python scripting language, allowing the encapsulation of entire kinematic experiments within high-level class definitions and fully reproducible results. In addition, we provide a~link to geophysical potential-field simulations to evaluate the effect of parameter uncertainties on maps of gravity and magnetics. We provide relevant fundamental information on kinematic modelling and our implementation, and showcase the application of our novel methods to investigate the interaction of multiple tectonic events on a pre-defined stratigraphy, the effect of changing kinematic parameters on simulated geophysical potential-fields, and the distribution of uncertain areas in a full 3-D kinematic model, based on estimated uncertainties in kinematic input parameters. Additional possibilities for linking kinematic modelling to subsequent process simulations are discussed, as well as additional aspects of future research. Our modules are freely available on github, including documentation and tutorial examples, and we encourage the contribution to this project.

  1. 3D Motion Planning Algorithms for Steerable Needles Using Inverse Kinematics

    PubMed Central

    Duindam, Vincent; Xu, Jijie; Alterovitz, Ron; Sastry, Shankar; Goldberg, Ken

    2010-01-01

    Steerable needles can be used in medical applications to reach targets behind sensitive or impenetrable areas. The kinematics of a steerable needle are nonholonomic and, in 2D, equivalent to a Dubins car with constant radius of curvature. In 3D, the needle can be interpreted as an airplane with constant speed and pitch rate, zero yaw, and controllable roll angle. We present a constant-time motion planning algorithm for steerable needles based on explicit geometric inverse kinematics similar to the classic Paden-Kahan subproblems. Reachability and path competitivity are analyzed using analytic comparisons with shortest path solutions for the Dubins car (for 2D) and numerical simulations (for 3D). We also present an algorithm for local path adaptation using null-space results from redundant manipulator theory. Finally, we discuss several ways to use and extend the inverse kinematics solution to generate needle paths that avoid obstacles. PMID:21359051

  2. 3D kinematics using dual quaternions: theory and applications in neuroscience

    PubMed Central

    Leclercq, Guillaume; Lefèvre, Philippe; Blohm, Gunnar

    2013-01-01

    In behavioral neuroscience, many experiments are developed in 1 or 2 spatial dimensions, but when scientists tackle problems in 3-dimensions (3D), they often face problems or new challenges. Results obtained for lower dimensions are not always extendable in 3D. In motor planning of eye, gaze or arm movements, or sensorimotor transformation problems, the 3D kinematics of external (stimuli) or internal (body parts) must often be considered: how to describe the 3D position and orientation of these objects and link them together? We describe how dual quaternions provide a convenient way to describe the 3D kinematics for position only (point transformation) or for combined position and orientation (through line transformation), easily modeling rotations, translations or screw motions or combinations of these. We also derive expressions for the velocities of points and lines as well as the transformation velocities. Then, we apply these tools to a motor planning task for manual tracking and to the modeling of forward and inverse kinematics of a seven-dof three-link arm to show the interest of dual quaternions as a tool to build models for these kinds of applications. PMID:23443667

  3. The influence of different footwear on 3-D kinematics and muscle activation during the barbell back squat in males.

    PubMed

    Sinclair, Jonathan; McCarthy, Derek; Bentley, Ian; Hurst, Howard Thomas; Atkins, Stephen

    2015-01-01

    The barbell back squat is commonly used by athletes participating in resistance training. The barbell squat is typically performed using standard athletic shoes, or specially designed weightlifting footwear, although there are now a large number of athletes who prefer to squat barefoot or in barefoot-inspired footwear. This study aimed to determine how these footwear influence 3-D kinematics and muscle activation potentials during the barbell back squat. Fourteen experienced male participants completed squats at 70% 1 rep max in each footwear condition. 3-D kinematics from the torso, hip, knee and ankle were measured using an eight-camera motion analysis system. In addition, electromyographical (EMG) measurements were obtained from the rectus femoris, tibialis anterior, gastrocnemius, erector spinae and biceps femoris muscles. EMG parameters and joint kinematics were compared between footwear using repeated-measures analyses of variance. Participants were also asked to subjectively rate which footwear they preferred when performing their squat lifts; this was examined a chi-squared test. The kinematic analysis indicated that, in comparison to barefoot the running shoe was associated with increased squat depth, knee flexion and rectus femoris activation. The chi-squared test was significant and showed that participants preferred to squat barefoot. This study supports anecdotal evidence of athletes who prefer to train barefoot or in barefoot-inspired footwear although no biomechanical evidence was found to support this notion.

  4. Evaluation of RSA set-up from a clinical biplane fluoroscopy system for 3D joint kinematic analysis

    PubMed Central

    BONANZINGA, TOMMASO; SIGNORELLI, CECILIA; BONTEMPI, MARCO; RUSSO, ALESSANDRO; ZAFFAGNINI, STEFANO; MARCACCI, MAURILIO; BRAGONZONI, LAURA

    2016-01-01

    Purpose dinamic roentgen stereophotogrammetric analysis (RSA), a technique currently based only on customized radiographic equipment, has been shown to be a very accurate method for detecting three-dimensional (3D) joint motion. The aim of the present work was to evaluate the applicability of an innovative RSA set-up for in vivo knee kinematic analysis, using a biplane fluoroscopic image system. To this end, the Authors describe the set-up as well as a possible protocol for clinical knee joint evaluation. The accuracy of the kinematic measurements is assessed. Methods the Authors evaluated the accuracy of 3D kinematic analysis of the knee in a new RSA set-up, based on a commercial biplane fluoroscopy system integrated into the clinical environment. The study was organized in three main phases: an in vitro test under static conditions, an in vitro test under dynamic conditions reproducing a flexion-extension range of motion (ROM), and an in vivo analysis of the flexion-extension ROM. For each test, the following were calculated, as an indication of the tracking accuracy: mean, minimum, maximum values and standard deviation of the error of rigid body fitting. Results in terms of rigid body fitting, in vivo test errors were found to be 0.10±0.05 mm. Phantom tests in static and kinematic conditions showed precision levels, for translations and rotations, of below 0.1 mm/0.2° and below 0.5 mm/0.3° respectively for all directions. Conclusions the results of this study suggest that kinematic RSA can be successfully performed using a standard clinical biplane fluoroscopy system for the acquisition of slow movements of the lower limb. Clinical relevance a kinematic RSA set-up using a clinical biplane fluoroscopy system is potentially applicable and provides a useful method for obtaining better characterization of joint biomechanics. PMID:27602352

  5. A kinematic model for 3-D head-free gaze-shifts

    PubMed Central

    Daemi, Mehdi; Crawford, J. Douglas

    2015-01-01

    Rotations of the line of sight are mainly implemented by coordinated motion of the eyes and head. Here, we propose a model for the kinematics of three-dimensional (3-D) head-unrestrained gaze-shifts. The model was designed to account for major principles in the known behavior, such as gaze accuracy, spatiotemporal coordination of saccades with vestibulo-ocular reflex (VOR), relative eye and head contributions, the non-commutativity of rotations, and Listing's and Fick constraints for the eyes and head, respectively. The internal design of the model was inspired by known and hypothesized elements of gaze control physiology. Inputs included retinocentric location of the visual target and internal representations of initial 3-D eye and head orientation, whereas outputs were 3-D displacements of eye relative to the head and head relative to shoulder. Internal transformations decomposed the 2-D gaze command into 3-D eye and head commands with the use of three coordinated circuits: (1) a saccade generator, (2) a head rotation generator, (3) a VOR predictor. Simulations illustrate that the model can implement: (1) the correct 3-D reference frame transformations to generate accurate gaze shifts (despite variability in other parameters), (2) the experimentally verified constraints on static eye and head orientations during fixation, and (3) the experimentally observed 3-D trajectories of eye and head motion during gaze-shifts. We then use this model to simulate how 2-D eye-head coordination strategies interact with 3-D constraints to influence 3-D orientations of the eye-in-space, and the implications of this for spatial vision. PMID:26113816

  6. The relationship between 3-D kinematics and gliding performance in the southern flying squirrel, Glaucomys volans.

    PubMed

    Bishop, Kristin L

    2006-02-01

    Gliding is the simplest form of flight, yet relatively little is known about its mechanics in animals. The goal of this study was to describe the body position and performance of a gliding mammal and to identify correlates between kinematics and aerodynamic performance. To do this, I used a pair of high-speed digital cameras to record a portion of the middle of glides by southern flying squirrels, Glaucomys volans. The squirrels launched from a height of 4 m and landed on a vertical pole. Reflective markers were applied to anatomical landmarks and the 3-D coordinates of these points were computed to describe the kinematics of the glides. From these data I estimated the lift and drag generated during the glide, and correlated these variables with gliding performance as measured by glide angle, glide speed and stability. In the majority of the glide sequences the squirrels accelerated in the downward direction and accelerated horizontally forward as they moved through the calibrated volume in the middle of the glide trajectory, rather than exhibiting a steady glide in which the body weight is balanced by the resultant aerodynamic force. Compared to human engineered airfoils, the angles of attack used by the squirrels were unexpectedly high, ranging from 35.4 degrees to 53.5 degrees , far above the angle of attack at which an aircraft wing would typically stall. As expected based on aerodynamic theory, there was a negative correlation between angle of attack and lift coefficient, indicating that the wings are stalled, and a positive correlation between angle of attack and drag coefficient. Also as expected, there was a negative correlation between lift-to-drag ratio and angle of attack, as increasing angle of attack produced both less lift and more drag. Within glides, there was a strong correlation between nose-down pitching rotations and limb movements that tended to increase the angle of attack of the wing membrane, suggesting that the animals actively control

  7. Kinematics of a growth fault/raft system on the West African margin using 3-D restoration

    NASA Astrophysics Data System (ADS)

    Rouby, Delphine; Raillard, Stéphane; Guillocheau, François; Bouroullec, Renaud; Nalpas, Thierry

    2002-04-01

    The ability to quantify the movement history associated with growth structures is crucial in the understanding of fundamental processes such as the growth of folds or faults in 3-D. In this paper, we present an application of an original approach to restore in 3-D a listric growth fault system resulting from gravity-induced extension located on the West African margin. Our goal is to establish the 3-D structural framework and kinematics of the study area. We construct a 3-D geometrical model of the fault system (from 3-D seismic data), then restore six stratigraphic surfaces and reconstruct the 3-D geometry of the system at six incremental steps of its history. The evolution of the growth fault/raft system corresponds to the progressive separation of two rafts by regional extension, resulting in the development of an intervening basin located between them that evolved in three main stages: (1) the rise of an evaporite wall, (2) the development of a symmetric basin as the elevation of the diapir is reduced and buried, and (3) the development of asymmetric basins related to two systems of listric faults (the main fault F1 and the graben located between the rollovers and the lower raft). Important features of the growth fault/raft system could only be observed in 3-D and with increments of deformation restored. The rollover anticline (associated with the listric fault F1) is composed of two sub-units separated by an E-W oriented transverse graben indicating that the displacement field was divergent in map view. The rollover units are located within the overlap area of two fault systems and displays a 'mock-turtle' anticline structure. The seaward translation of the lower raft is associated with two successive vertical axis rotations in the opposite sense (clockwise then counter-clockwise by about 10°). This results from the fact that the two main fault systems developed successively. Fault system F1 formed during the Upper Albian, and the graben during the Cenomanian

  8. Impedance mammograph 3D phantom studies.

    PubMed

    Wtorek, J; Stelter, J; Nowakowski, A

    1999-04-20

    The results obtained using the Technical University of Gdansk Electroimpedance Mammograph (TUGEM) of a 3D phantom study are presented. The TUGEM system is briefly described. The hardware contains the measurement head and DSP-based identification modules controlled by a PC computer. A specially developed reconstruction algorithm, Regulated Correction Frequency Algebraic Reconstruction Technique (RCFART), is used to obtain 3D images. To visualize results, the Advance Visualization System (AVS) is used. It allows a powerful image processing on a fast workstation or on a high-performance computer. Results of three types of 3D conductivity perturbations used in the study (aluminum, Plexiglas, and cucumber) are shown. The relative volumes of perturbations less than 2% of the measurement chamber are easily evidenced.

  9. 3D kinematic in-vitro comparison of posterolateral corner reconstruction techniques in a combined injury model.

    PubMed

    Nau, Thomas; Chevalier, Yan; Hagemeister, Nicola; Duval, Nicolas; deGuise, Jacques A

    2005-10-01

    With the variable injury pattern to the posterolateral structures (PLS) of the knee, a number of reconstructive procedures have been introduced. It was the aim of the present study to evaluate the resulting 3D kinematics following three different surgical techniques of reconstruction in a combined posterior cruciate ligament (PCL)/PLS injury model. In nine human cadaveric knees, 3D kinematics were recorded during the path of flexion-extension using a computer based custom made 6-degree-of-freedom (DOF) testing apparatus. Additional laxity tests were conducted at 30 and 90 degrees of flexion. Testing was performed before and after cutting the PLS and PCL, followed by PCL reconstruction alone. Reconstructing the posterolateral corner, three surgical techniques were compared: (a) the posterolateral corner sling procedure (PLCS), (b) the biceps tenodesis (BT), and (c) a bone patellar-tendon bone (BTB) allograft reconstruction. Posterior as well as rotational laxity were significantly increased after PCL/PLS transection at 30 and 90 degrees of flexion. Isolated PCL reconstruction resulted in a remaining external rotational deficiency for both tested flexion angles. Additional PLS reconstruction closely restored external rotation as well as posterior translation to intact values by all tested procedures. Compared to the intact knee, dynamic testing revealed a significant internal tibial rotation for (b) BT (mean=3.9 degrees, p=0.043) and for (c) BTB allograft (mean=4.3 degrees, p=0.012). (a) The PLCS demonstrated a tendency to internal tibial rotation between 0 and 60 degrees of flexion (mean=2.2 degrees, p=0.079). Varus/valgus rotation as well as anterior/posterior translation did not show significant differences for any of the tested techniques. The present study shows that despite satisfying results in static laxity testing, pathological 3D knee kinematics were not restored to normal, demonstrated by a nonphysiological internal tibial rotation during the path of

  10. A Cray T3D performance study

    SciTech Connect

    Nallana, A.; Kincaid, D.R.

    1996-05-01

    We carry out a performance study using the Cray T3D parallel supercomputer to illustrate some important features of this machine. Timing experiments show the speed of various basic operations while more complicated operations give some measure of its parallel performance.

  11. Initial Comparison Between a 3D MHD Model and the HAFv2 Kinematic 3D Model: The October/November 2003 Events from the Sun to 6 AU

    SciTech Connect

    Intriligator, Devrie S.; Detman, Thomas; Fry, Craig D.; Sun Wei; Deehr, Charles; Intriligator, James

    2005-08-01

    A first-generation 3D kinematic, space weather forecasting solar wind model (HAFv2) has been used to show the importance of solar generated disturbances in Voyager 1 and Voyager 2 observations in the outer heliosphere. We extend this work by using a 3D MHD model (HHMS) that, like HAFv2, incorporates a global, pre-event, inhomogeneous, background solar wind plasma and interplanetary magnetic field. Initial comparisons are made between the two models of the solar wind out to 6 AU and with in-situ observations at the ACE spacecraft before and after the October/November 2003 solar events.

  12. Closed-loop control concept for kinematic 3D-profile bending

    NASA Astrophysics Data System (ADS)

    Staupendahl, Daniel; Chatti, Sami; Tekkaya, A. Erman

    2016-10-01

    Kinematic tube and profile bending processes produce bending contours by the relative movement of single process axes. Tools only need to be adapted to fit the cross-section of the tubular material. While offering a great flexibility in production, kinematic bending processes cause a high part springback and as a result, compensatory methods are needed to achieve target contours. These compensatory methods are generally embedded in bending tables or analytical calculations that in turn are embedded into the process control software. This procedure can cope with known material behavior, as for instance gained through a tensile test of the material batch prior to the bending process. Material variations inside a batch cannot be detected however and cause contour deviations. To counter this error, a closed-loop control system can be used, which can quickly adapt axes' movements to produce target shapes and thus reduce scrap. In this paper, two methods to apply closed-loop control to 3D profile bending will be presented. An indirect approach, using the bending force and torque, and a direct approach, by measuring the profile contour after bending.

  13. 3D kinematics of the near-IR HH 223 outflow in L723

    NASA Astrophysics Data System (ADS)

    López, R.; Acosta-Pulido, J. A.; Estalella, R.; Gómez, G.; García-Lorenzo, B.

    2015-03-01

    In this work, we derive the full 3D kinematics of the near-infrared outflow HH 223, located in the dark cloud Lynds 723 (L723), where a well-defined quadrupolar CO outflow is found. HH 223 appears projected on to the two lobes of the east-west CO outflow. The radio continuum source VLA 2, towards the centre of the CO outflow, harbours a multiple system of low-mass young stellar objects. One of the components has been proposed to be the exciting source of the east-west CO outflow. From the analysis of the kinematics, we get further evidence on the relationship between the near-infrared and CO outflows and on the location of their exciting source. The proper motions were derived using multi-epoch, narrow-band H2 (2.122 μm line) images. Radial velocities were derived from the 2.122 μm line of the spectra. Because of the extended (˜5 arcmin), S-shaped morphology of the target, the spectra were obtained with the multi-object-spectroscopy (MOS) observing mode using the instrument Long-Slit Intermediate Resolution Infrared Spectrograph (LIRIS) at the 4.2 m William Herschel Telescope. To our knowledge, this work is the first time that MOS observing mode has been successfully used in the near-infrared range for an extended target.

  14. Markerless motion capture can provide reliable 3D gait kinematics in the sagittal and frontal plane.

    PubMed

    Sandau, Martin; Koblauch, Henrik; Moeslund, Thomas B; Aanæs, Henrik; Alkjær, Tine; Simonsen, Erik B

    2014-09-01

    Estimating 3D joint rotations in the lower extremities accurately and reliably remains unresolved in markerless motion capture, despite extensive studies in the past decades. The main problems have been ascribed to the limited accuracy of the 3D reconstructions. Accordingly, the purpose of the present study was to develop a new approach based on highly detailed 3D reconstructions in combination with a translational and rotational unconstrained articulated model. The highly detailed 3D reconstructions were synthesized from an eight camera setup using a stereo vision approach. The subject specific articulated model was generated with three rotational and three translational degrees of freedom for each limb segment and without any constraints to the range of motion. This approach was tested on 3D gait analysis and compared to a marker based method. The experiment included ten healthy subjects in whom hip, knee and ankle joint were analysed. Flexion/extension angles as well as hip abduction/adduction closely resembled those obtained from the marker based system. However, the internal/external rotations, knee abduction/adduction and ankle inversion/eversion were less reliable.

  15. Beowulf 3D: a case study

    NASA Astrophysics Data System (ADS)

    Engle, Rob

    2008-02-01

    This paper discusses the creative and technical challenges encountered during the production of "Beowulf 3D," director Robert Zemeckis' adaptation of the Old English epic poem and the first film to be simultaneously released in IMAX 3D and digital 3D formats.

  16. Analysis of 3D kinematics concerning three different clubs in golf swing.

    PubMed

    Egret, C I; Vincent, O; Weber, J; Dujardin, F H; Chollet, D

    2003-08-01

    Although many professionals have produced books or videotapes which offer a novel approach to the game, a review of the scientific literature reports limited research evaluating the actual biomechanics of the golf swing in comparison with other sports. The aim of this study was to investigate the influence of kinematic pattern in golf swing using three different clubs: driver, five-iron, pitching-wedge. These three golf clubs have been chosen for their available range of ball flight. The measures of kinematic data during swing were established with the optoelectronic system VICON (Oxford's Metrics, Oxford, UK) with five cameras operating at 50 frames per second. Clubhead speed was measured using a swing made detector (Bell-Tronics, Ltd, Covington, USA). Seven right-handed male golfers with a high level of skill participated in the study. The results showed that there was an identical timing (movement time and proportion for each phase of the swing) between the three clubs tested, but the kinematics and the clubhead speed were different depending on the three different clubs used.

  17. Development of kinematic 3D laser scanning system for indoor mapping and as-built BIM using constrained SLAM.

    PubMed

    Jung, Jaehoon; Yoon, Sanghyun; Ju, Sungha; Heo, Joon

    2015-10-16

    The growing interest and use of indoor mapping is driving a demand for improved data-acquisition facility, efficiency and productivity in the era of the Building Information Model (BIM). The conventional static laser scanning method suffers from some limitations on its operability in complex indoor environments, due to the presence of occlusions. Full scanning of indoor spaces without loss of information requires that surveyors change the scanner position many times, which incurs extra work for registration of each scanned point cloud. Alternatively, a kinematic 3D laser scanning system, proposed herein, uses line-feature-based Simultaneous Localization and Mapping (SLAM) technique for continuous mapping. Moreover, to reduce the uncertainty of line-feature extraction, we incorporated constrained adjustment based on an assumption made with respect to typical indoor environments: that the main structures are formed of parallel or orthogonal line features. The superiority of the proposed constrained adjustment is its reduction for uncertainties of the adjusted lines, leading to successful data association process. In the present study, kinematic scanning with and without constrained adjustment were comparatively evaluated in two test sites, and the results confirmed the effectiveness of the proposed system. The accuracy of the 3D mapping result was additionally evaluated by comparison with the reference points acquired by a total station: the Euclidean average distance error was 0.034 m for the seminar room and 0.043 m for the corridor, which satisfied the error tolerance for point cloud acquisition (0.051 m) according to the guidelines of the General Services Administration for BIM accuracy.

  18. Isotropic at the Break? 3D Kinematics of Milky Way Halo Stars in the Foreground of M31

    NASA Astrophysics Data System (ADS)

    Cunningham, Emily C.; Deason, Alis J.; Guhathakurta, Puragra; Rockosi, Constance M.; van der Marel, Roeland P.; Toloba, Elisa; Gilbert, Karoline M.; Sohn, Sangmo Tony; Dorman, Claire E.

    2016-03-01

    We present the line-of-sight (LOS) velocities for 13 distant main sequence Milky Way halo stars with published proper motions (PMs). The PMs were measured using long baseline (5-7 years) multi-epoch Hubble Space Telescope/Advanced Camera for Surveys photometry, and the LOS velocities were extracted from deep (5-6 hr integrations) Keck II/DEIMOS spectra. We estimate the parameters of the velocity ellipsoid of the stellar halo using a Markov chain Monte Carlo ensembler sampler method. The velocity second moments in the directions of the Galactic (l, b, LOS) coordinate system are {< {v}l2> }1/2={138}-26+43 km s-1, {< {v}b2> }1/2={88}-17+28 {\\text{km s}}-1, and {< {v}{{LOS}}2> }1/2={91}-14+27 {\\text{km s}}-1. We use these ellipsoid parameters to constrain the velocity anisotropy of the stellar halo. Ours is the first measurement of the anisotropy parameter β using 3D kinematics outside of the solar neighborhood. We find β =-{0.3}-0.9+0.4, consistent with isotropy and lower than solar neighborhood β measurements by 2σ (βSN ˜ 0.5-0.7). We identify two stars in our sample that are likely members of the known TriAnd substructure, and excluding these objects from our sample increases our estimate of the anisotropy to β ={0.1}-1.0+0.4, which is still lower than solar neighborhood measurements by 1σ. The potential decrease in β with Galactocentric radius is inconsistent with theoretical predictions, though consistent with recent observational studies, and may indicate the presence of large, shell-type structure (or structures) at r ˜ 25 kpc. The methods described in this paper will be applied to a much larger sample of stars with 3D kinematics observed through the ongoing HALO7D program.

  19. Development of Kinematic 3D Laser Scanning System for Indoor Mapping and As-Built BIM Using Constrained SLAM

    PubMed Central

    Jung, Jaehoon; Yoon, Sanghyun; Ju, Sungha; Heo, Joon

    2015-01-01

    The growing interest and use of indoor mapping is driving a demand for improved data-acquisition facility, efficiency and productivity in the era of the Building Information Model (BIM). The conventional static laser scanning method suffers from some limitations on its operability in complex indoor environments, due to the presence of occlusions. Full scanning of indoor spaces without loss of information requires that surveyors change the scanner position many times, which incurs extra work for registration of each scanned point cloud. Alternatively, a kinematic 3D laser scanning system, proposed herein, uses line-feature-based Simultaneous Localization and Mapping (SLAM) technique for continuous mapping. Moreover, to reduce the uncertainty of line-feature extraction, we incorporated constrained adjustment based on an assumption made with respect to typical indoor environments: that the main structures are formed of parallel or orthogonal line features. The superiority of the proposed constrained adjustment is its reduction for uncertainties of the adjusted lines, leading to successful data association process. In the present study, kinematic scanning with and without constrained adjustment were comparatively evaluated in two test sites, and the results confirmed the effectiveness of the proposed system. The accuracy of the 3D mapping result was additionally evaluated by comparison with the reference points acquired by a total station: the Euclidean average distance error was 0.034 m for the seminar room and 0.043 m for the corridor, which satisfied the error tolerance for point cloud acquisition (0.051 m) according to the guidelines of the General Services Administration for BIM accuracy. PMID:26501292

  20. Kinematic ground motion simulations on rough faults including effects of 3D stochastic velocity perturbations

    USGS Publications Warehouse

    Graves, Robert; Pitarka, Arben

    2016-01-01

    We describe a methodology for generating kinematic earthquake ruptures for use in 3D ground‐motion simulations over the 0–5 Hz frequency band. Our approach begins by specifying a spatially random slip distribution that has a roughly wavenumber‐squared fall‐off. Given a hypocenter, the rupture speed is specified to average about 75%–80% of the local shear wavespeed and the prescribed slip‐rate function has a Kostrov‐like shape with a fault‐averaged rise time that scales self‐similarly with the seismic moment. Both the rupture time and rise time include significant local perturbations across the fault surface specified by spatially random fields that are partially correlated with the underlying slip distribution. We represent velocity‐strengthening fault zones in the shallow (<5  km) and deep (>15  km) crust by decreasing rupture speed and increasing rise time in these regions. Additional refinements to this approach include the incorporation of geometric perturbations to the fault surface, 3D stochastic correlated perturbations to the P‐ and S‐wave velocity structure, and a damage zone surrounding the shallow fault surface characterized by a 30% reduction in seismic velocity. We demonstrate the approach using a suite of simulations for a hypothetical Mw 6.45 strike‐slip earthquake embedded in a generalized hard‐rock velocity structure. The simulation results are compared with the median predictions from the 2014 Next Generation Attenuation‐West2 Project ground‐motion prediction equations and show very good agreement over the frequency band 0.1–5 Hz for distances out to 25 km from the fault. Additionally, the newly added features act to reduce the coherency of the radiated higher frequency (f>1  Hz) ground motions, and homogenize radiation‐pattern effects in this same bandwidth, which move the simulations closer to the statistical characteristics of observed motions as illustrated by comparison with recordings from

  1. Magnitude and pattern of 3D kinematic and kinetic gait profiles in persons with stroke: relationship to walking speed.

    PubMed

    Kim, C Maria; Eng, Janice J

    2004-10-01

    The purpose of this study was to identify 3D kinematic and kinetic gait profiles in individuals with chronic stroke and to determine whether the magnitude or pattern (shape and direction of curve) of these profiles relate to gait performance (as measured by self-selected gait speed). More than one type of kinematic and kinetic pattern was identified in all three planes in 20 individuals with stroke (age: 61.2+/-8.4 years). Persons in the "fast" speed group did not necessarily exhibit the gait patterns closest to the ones reported for healthy adults. For example, in the frontal plane, a variation from the typical pattern (i.e., a hip abductor pattern in swing) was more common among the "fast" group. Correlations revealed that in addition to the sagittal profiles, the magnitudes of the frontal and transverse profiles are also related to speed, particularly the frontal hip powers. The results support the importance of hip abductors, in addition to the sagittal plane muscle groups, for both the paretic and non-paretic limbs. Furthermore, profiles which resemble gait patterns of neurologically healthy adults do not necessarily result in the faster gait speeds for individuals with chronic stroke.

  2. Kinematics of local and high-z galaxies through 3D modeling of emission-line datacubes

    NASA Astrophysics Data System (ADS)

    Di Teodoro, Enrico M.

    2015-12-01

    The kinematics is a fundamental tool to infer the dynamical structure of galaxies and to understand their formation and evolution. Spectroscopic observations of gas emission lines are often used to derive rotation curves and velocity dispersions. It is however difficult to disentangle these two quantities in low spatial-resolution data because of beam smearing. In this thesis, we present 3D-Barolo, a new software to derive the gas kinematics of disk galaxies from emission-line data-cubes. The code builds tilted-ring models in the 3D observational space and compares them with the actual data-cubes. 3D-Barolo works with data at a wide range of spatial resolutions without being affected by instrumental biases. We use 3D-Barolo to derive rotation curves and velocity dispersions of several galaxies in both the local and the high-redshift Universe. We run our code on HI observations of nearby galaxies and we compare our results with 2D traditional approaches. We show that a 3D approach to the derivation of the gas kinematics has to be preferred to a 2D approach whenever a galaxy is resolved with less than about 20 elements across the disk. We moreover analyze a sample of galaxies at z~1, observed in the H-alpha line with the KMOS/VLT spectrograph. Our 3D modeling reveals that the kinematics of these high-z systems is comparable to that of local disk galaxies, with steeply-rising rotation curves followed by a flat part and H-alpha velocity dispersions of 15-40 km/s over the whole disks. This evidence suggests that disk galaxies were already fully settled about 7-8 billion years ago. In summary, 3D-Barolo is a powerful and robust tool to separate physical and instrumental effects and to derive a reliable kinematics. The analysis of large samples of galaxies at different redshifts with 3D-Barolo will provide new insights on how galaxies assemble and evolve throughout cosmic time.

  3. 3D kinematics of the tarsal joints from magnetic resonance images

    NASA Astrophysics Data System (ADS)

    Hirsch, Bruce E.; Udupa, Jayaram K.; Okereke, Enyi; Hillstrom, Howard J.; Siegler, Sorin; Ringleb, Stacie I.; Imhauser, Carl W.

    2001-09-01

    We have developed a method for analyzing motion at skeletal joints based on the 3D reconstruction of magnetic resonance (MR) image data. Since the information about each voxel in MR images includes its location in the scanner, it follows that information is available for each organ whose 3D surface is computed from a series of MR slices. In addition, there is information on the shape and orientation of each organ, and the contact areas of adjacent bones. By collecting image data in different positions we can calculate the motion of the individual bones. We have used this method to study human foot bones, in order to understand normal and abnormal foot function. It has been used to evaluate patients with tarsal coalitions, various forms of pes planus, ankle sprains, and several other conditions. A newly described feature of this system is the ability to visualize the contact area at a joint, as determined by the region of minimum distance. The display of contact area helps understand abnormal joint function. Also, the use of 3D imaging reveals motions in joints which cannot otherwise be visualized, such as the subtalar joint, for more accurate diagnosis of joint injury.

  4. The appropriateness of the helical axis technique and six available cardan sequences for the representation of 3-d lead leg kinematics during the fencing lunge.

    PubMed

    Sinclair, Jonathan; Taylor, Paul J; Bottoms, Lindsay

    2013-01-01

    Cardan/Euler angles represent the most common technique for the quantification of segmental rotations. Cardan angles are influenced by their ordered sequence, and sensitive to planar-cross talk from the dominant rotation plane, which may affect the angular parameters. The International Society of Biomechanics (ISB) currently recommends a sagittal, coronal, and then transverse (XYZ) ordered sequence, although it has been proposed that when quantifying non-sagittal rotations this may not be the most appropriate technique. This study examined the influence of the helical and six available Cardan sequences on lower extremity three-dimensional (3-D) kinematics of the lead leg during the fencing lunge. Kinematic data were obtained using a 3-D motion capture system as participants completed simulated lunges. Repeated measures ANOVAs were used to compare discrete kinematic parameters, and intraclass correlations were also utilized to determine evidence of planar crosstalk. The results indicate that in all three planes of rotation, peak angle and range of motion angles using the YXZ and ZXY sequences were significantly greater than the other sequences. It was also noted that the utilization of the YXZ and ZXY sequences was associated with the strongest correlations from the sagittal plane, and the XYZ sequence was found habitually to be associated with the lowest correlations. It appears that for accurate representation of 3-D kinematics of the lead leg during the fencing lunge, the XYZ sequence is the most appropriate and as such its continued utilization is encouraged.

  5. The Appropriateness of the Helical Axis Technique and Six Available Cardan Sequences for the Representation of 3-D Lead Leg Kinematics During the Fencing Lunge

    PubMed Central

    Sinclair, Jonathan; Taylor, Paul J; Bottoms, Lindsay

    Cardan/Euler angles represent the most common technique for the quantification of segmental rotations. Cardan angles are influenced by their ordered sequence, and sensitive to planar-cross talk from the dominant rotation plane, which may affect the angular parameters. The International Society of Biomechanics (ISB) currently recommends a sagittal, coronal, and then transverse (XYZ) ordered sequence, although it has been proposed that when quantifying non-sagittal rotations this may not be the most appropriate technique. This study examined the influence of the helical and six available Cardan sequences on lower extremity three-dimensional (3-D) kinematics of the lead leg during the fencing lunge. Kinematic data were obtained using a 3-D motion capture system as participants completed simulated lunges. Repeated measures ANOVAs were used to compare discrete kinematic parameters, and intraclass correlations were also utilized to determine evidence of planar crosstalk. The results indicate that in all three planes of rotation, peak angle and range of motion angles using the YXZ and ZXY sequences were significantly greater than the other sequences. It was also noted that the utilization of the YXZ and ZXY sequences was associated with the strongest correlations from the sagittal plane, and the XYZ sequence was found habitually to be associated with the lowest correlations. It appears that for accurate representation of 3-D kinematics of the lead leg during the fencing lunge, the XYZ sequence is the most appropriate and as such its continued utilization is encouraged. PMID:24146700

  6. A volumetric model-based 2D to 3D registration method for measuring kinematics of natural knees with single-plane fluoroscopy

    SciTech Connect

    Tsai, Tsung-Yuan; Lu, Tung-Wu; Chen, Chung-Ming; Kuo, Mei-Ying; Hsu, Horng-Chaung

    2010-03-15

    Purpose: Accurate measurement of the three-dimensional (3D) rigid body and surface kinematics of the natural human knee is essential for many clinical applications. Existing techniques are limited either in their accuracy or lack more realistic experimental evaluation of the measurement errors. The purposes of the study were to develop a volumetric model-based 2D to 3D registration method, called the weighted edge-matching score (WEMS) method, for measuring natural knee kinematics with single-plane fluoroscopy to determine experimentally the measurement errors and to compare its performance with that of pattern intensity (PI) and gradient difference (GD) methods. Methods: The WEMS method gives higher priority to matching of longer edges of the digitally reconstructed radiograph and fluoroscopic images. The measurement errors of the methods were evaluated based on a human cadaveric knee at 11 flexion positions. Results: The accuracy of the WEMS method was determined experimentally to be less than 0.77 mm for the in-plane translations, 3.06 mm for out-of-plane translation, and 1.13 deg. for all rotations, which is better than that of the PI and GD methods. Conclusions: A new volumetric model-based 2D to 3D registration method has been developed for measuring 3D in vivo kinematics of natural knee joints with single-plane fluoroscopy. With the equipment used in the current study, the accuracy of the WEMS method is considered acceptable for the measurement of the 3D kinematics of the natural knee in clinical applications.

  7. Scenario Testing and Sensitivity Analysis for 3-D Kinematic Models and Geophysical Fields

    NASA Astrophysics Data System (ADS)

    Wellmann, Florian; Lindsay, Mark; Jessell, Mark

    2015-04-01

    Geological models are widely used to represent the structural setting of the subsurface. Commonly, a single model is generated for a region, representing the best interpretation of the structural setting in the light of all available information. It is, however, widely accepted that a such created model still contains uncertainties. We hypothesise here that it is possible to transform a single kinematic model into a powerful predictive tool for scenario analysis and uncertainty quantification. We extend the functionality of a kinematic structural and geophysical modelling approach, implemented in the software Noddy, with a set newly developed Python modules to expose, generalise and automate essential parts of the modelling workflow. We show how these methods enable us to quickly generate and analyse different geological scenarios. In addition to the geological model, Noddy also enables the direct calculation of geophysical fields of gravity and magnetics. We can use this functionality to compare the model to measured potential fields. With an example for a fold and thrust belt model, we show how to quickly estimate how changes in the model (due to parameter uncertainties, for example) affect the calculated gravity field in the model range. Finally, we present the possibility to efficiently generate an ensemble of model realisations for predictive geomodel analysis with an application to a case study in the Gippsland Basin, Victoria. The results show that our approach can successfully extend the functionality of traditional modelling methods with an additional layer of predictive power towards an efficient evaluation of uncertainties in structural geological models.

  8. Case study: Beauty and the Beast 3D: benefits of 3D viewing for 2D to 3D conversion

    NASA Astrophysics Data System (ADS)

    Handy Turner, Tara

    2010-02-01

    From the earliest stages of the Beauty and the Beast 3D conversion project, the advantages of accurate desk-side 3D viewing was evident. While designing and testing the 2D to 3D conversion process, the engineering team at Walt Disney Animation Studios proposed a 3D viewing configuration that not only allowed artists to "compose" stereoscopic 3D but also improved efficiency by allowing artists to instantly detect which image features were essential to the stereoscopic appeal of a shot and which features had minimal or even negative impact. At a time when few commercial 3D monitors were available and few software packages provided 3D desk-side output, the team designed their own prototype devices and collaborated with vendors to create a "3D composing" workstation. This paper outlines the display technologies explored, final choices made for Beauty and the Beast 3D, wish-lists for future development and a few rules of thumb for composing compelling 2D to 3D conversions.

  9. Characterizing Kinematics of Passive Tracer Paths in Simulations of Mantle Convection in a 3D Spherical Shell

    NASA Astrophysics Data System (ADS)

    Peterson, J. A.; Schröder, S.; Heien, E. M.; Turcotte, D. L.; Kellogg, L. H.

    2011-12-01

    Geochemical evidence from mantle-derived basalt at mid-ocean ridges and oceanic islands reveal a spectrum of heterogeneity in the mantle, with much of the MORB source largely homogeneous, while other regions may remain isolated for billions of years. Heterogeneity appears in MORB at all scales, as would be expected from sampling a marble-cake structure in the upper mantle. The origin of these diverse mantle reservoirs is poorly understood. In particular, although stirring has been studied extensively in 2D models of mantle convection and in 3D flows in a Cartesian box, the kinematics of mixing due to thermal convection in a 3D spherical shell is not well-characterized. To quantitatively investigate the mechanisms of stirring, we use the finite element model CitComS to carry out a series of models of convection in a spherical shell at low to moderate Rayleigh number. We use passive tracers as proxies for geochemical heterogeneity. We investigate both low-Rayleigh number isoviscous flows for which the pattern of convection reaches steady state, as well as the influence on stirring of the transition to time-varying flows. For each model, after the initial transient has passed, a field of particles is added and advected forward in time. We modified the passive tracer advection in CitcomS to enable precise long-term tracking of individual tracers. The particle paths are then visualized and quantitative measures of mixing are applied, such as the divergence of initial neighbors. Regions where particles do not intermix are located and residence times are calculated to determine the stability of the isolated regions.

  10. Real-Time Motion Capture Toolbox (RTMocap): an open-source code for recording 3-D motion kinematics to study action-effect anticipations during motor and social interactions.

    PubMed

    Lewkowicz, Daniel; Delevoye-Turrell, Yvonne

    2016-03-01

    We present here a toolbox for the real-time motion capture of biological movements that runs in the cross-platform MATLAB environment (The MathWorks, Inc., Natick, MA). It provides instantaneous processing of the 3-D movement coordinates of up to 20 markers at a single instant. Available functions include (1) the setting of reference positions, areas, and trajectories of interest; (2) recording of the 3-D coordinates for each marker over the trial duration; and (3) the detection of events to use as triggers for external reinforcers (e.g., lights, sounds, or odors). Through fast online communication between the hardware controller and RTMocap, automatic trial selection is possible by means of either a preset or an adaptive criterion. Rapid preprocessing of signals is also provided, which includes artifact rejection, filtering, spline interpolation, and averaging. A key example is detailed, and three typical variations are developed (1) to provide a clear understanding of the importance of real-time control for 3-D motion in cognitive sciences and (2) to present users with simple lines of code that can be used as starting points for customizing experiments using the simple MATLAB syntax. RTMocap is freely available (http://sites.google.com/site/RTMocap/) under the GNU public license for noncommercial use and open-source development, together with sample data and extensive documentation.

  11. CASTOR3D: linear stability studies for 2D and 3D tokamak equilibria

    NASA Astrophysics Data System (ADS)

    Strumberger, E.; Günter, S.

    2017-01-01

    The CASTOR3D code, which is currently under development, is able to perform linear stability studies for 2D and 3D, ideal and resistive tokamak equilibria in the presence of ideal and resistive wall structures and coils. For these computations ideal equilibria represented by concentric nested flux surfaces serve as input (e.g. computed with the NEMEC code). Solving an extended eigenvalue problem, the CASTOR3D code takes simultaneously plasma inertia and wall resistivity into account. The code is a hybrid of the CASTOR_3DW stability code and the STARWALL code. The former is an extended version of the CASTOR and CASTOR_FLOW code, respectively. The latter is a linear 3D code computing the growth rates of resistive wall modes in the presence of multiply-connected wall structures. The CASTOR_3DW code, and some parts of the STARWALL code have been reformulated in a general 3D flux coordinate representation that allows to choose between various types of flux coordinates. Furthermore, the implemented many-valued current potentials in the STARWALL part allow a correct treatment of the m  =  0, n  =  0 perturbation. In this paper, we outline the theoretical concept, and present some numerical results which illustrate the present status of the code and demonstrate its numerous application possibilities.

  12. Instantaneous helical axis estimation from 3-D video data in neck kinematics for whiplash diagnostics.

    PubMed

    Woltring, H J; Long, K; Osterbauer, P J; Fuhr, A W

    1994-12-01

    To date, the diagnosis of whiplash injuries has been very difficult and largely based on subjective, clinical assessment. The work by Winters and Peles Multiple Muscle Systems--Biomechanics and Movement Organization. Springer, New York (1990) suggests that the use of finite helical axes (FHAs) in the neck may provide an objective assessment tool for neck mobility. Thus, the position of the FHA describing head-trunk motion may allow discrimination between normal and pathological cases such as decreased mobility in particular cervical joints. For noisy, unsmoothed data, the FHAs must be taken over rather large angular intervals if the FHAs are to be reconstructed with sufficient accuracy; in the Winters and Peles study, these intervals were approximately 10 degrees. in order to study the movements' microstructure, the present investigation uses instantaneous helical axes (IHAs) estimated from low-pass smoothed video data. Here, the small-step noise sensitivity of the FHA no longer applies, and proper low-pass filtering allows estimation of the IHA even for small rotation velocity omega of the moving neck. For marker clusters mounted on the head and trunk, technical system validation showed that the IHAs direction dispersions were on the order of one degree, while their position dispersions were on the order of 1 mm, for low-pass cut-off frequencies of a few Hz (the dispersions were calculated from omega-weighted errors, in order to account for the adverse effects of vanishing omega). Various simple, planar models relating the instantaneous, 2-D centre of rotation with the geometry and kinematics of a multi-joint neck model are derived, in order to gauge the utility of the FHA and IHA approaches. Some preliminary results on asymptomatic and pathological subjects are provided, in terms of the 'ruled surface' formed by sampled IHAs and of their piercing points through the mid-sagittal plane during a prescribed flexion-extension movement of the neck.

  13. The development, preliminary validation and clinical utility of a shoe model to quantify foot and footwear kinematics in 3-D.

    PubMed

    Pratt, Emma J; Reeves, Mark L; van der Meulen, Jill M; Heller, Ben W; Good, Tim R

    2012-07-01

    Functional electrical stimulation (FES) applied to the common peroneal nerve is commonly prescribed to correct both equinus and excessive foot inversion in swing and initial contact. This paper presents the development of a simple shoe model, to allow quantification of 3-D shoe (foot and footwear) kinematics in clinical situations when footwear is required, e.g. with FES systems requiring footswitches. To preliminarily validate the shoe model, barefoot 'normal' adult data (n=11) processed using validated 3-D foot models, were reprocessed with the shoe model. Outputs were compared through calculation of waveform similarity and correlation. Clinical utility of the shoe model is demonstrated through the presentation of 3-D shoe kinematics, calculated from a cohort of existing unilateral common peroneal FES users (n=16), both with and without FES. A trend of reduced inversion at mid-swing and initial contact was seen, although this was not found to be statistically significant (p≤0.0125). The shoe model was found to be practical to use in a clinical environment, and has potential to contribute to the evidence base for interventions such as common peroneal FES.

  14. 3D shoulder kinematics for static vs dynamic and passive vs active testing conditions.

    PubMed

    Robert-Lachaine, Xavier; Allard, Paul; Godbout, Véronique; Begon, Mickael

    2015-09-18

    Shoulder motion analysis provides clinicians with references of normal joint rotations. Shoulder joints orientations assessment is often based on series of static positions, while clinicians perform either passive or active tests and exercises mostly in dynamic. These conditions of motion could modify joint coordination and lead to discrepancies with the established references. Hence, the objective was to evaluate the influence of static vs dynamic and passive vs active testing conditions on shoulder joints orientations. Twenty asymptomatic subjects setup with 45 markers on the upper limb and trunk were tracked by an optoelectronic system. Static positions (30°, 60°, 90° and 120° of thoracohumeral elevation) and dynamic motion both in active condition and passively mobilised by an examiner were executed. Three-dimensional sternoclavicular, acromioclavicular, scapulothoracic and glenohumeral joint angles (12 in total) representing the distal segment orientation relative to the proximal segment orientation were estimated using a shoulder kinematical chain model. Separate four-way repeated measures ANOVA were applied on the 12 joint angles with factors of static vs dynamic, passive vs active, thoracohumeral elevation angle (30°, 60°, 90° and 120°) and plane of elevation (frontal and sagittal). Scapulothoracic lateral rotation progressed more during arm elevation in static than in dynamic gaining 4.2° more, and also in passive than in active by 6.6°. Glenohumeral elevation increased more during arm elevation in active than in passive by 4.4°. Shoulder joints orientations are affected by the testing conditions, which should be taken into consideration for data acquisition, inter-study comparison or clinical applications.

  15. A methodology to accurately quantify patellofemoral cartilage contact kinematics by combining 3D image shape registration and cine-PC MRI velocity data.

    PubMed

    Borotikar, Bhushan S; Sipprell, William H; Wible, Emily E; Sheehan, Frances T

    2012-04-05

    Patellofemoral osteoarthritis and its potential precursor patellofemoral pain syndrome (PFPS) are common, costly, and debilitating diseases. PFPS has been shown to be associated with altered patellofemoral joint mechanics; however, an actual variation in joint contact stresses has not been established due to challenges in accurately quantifying in vivo contact kinematics (area and location). This study developed and validated a method for tracking dynamic, in vivo cartilage contact kinematics by combining three magnetic resonance imaging (MRI) techniques, cine-phase contrast (CPC), multi-plane cine (MPC), and 3D high-resolution static imaging. CPC and MPC data were acquired from 12 healthy volunteers while they actively extended/flexed their knee within the MRI scanner. Since no gold standard exists for the quantification of in vivo dynamic cartilage contact kinematics, the accuracy of tracking a single point (patellar origin relative to the femur) represented the accuracy of tracking the kinematics of an entire surface. The accuracy was determined by the average absolute error between the PF kinematics derived through registration of MPC images to a static model and those derived through integration of the CPC velocity data. The accuracy ranged from 0.47 mm to 0.77 mm for the patella and femur and from 0.68 mm to 0.86 mm for the patellofemoral joint. For purely quantifying joint kinematics, CPC remains an analytically simpler and more accurate (accuracy <0.33 mm) technique. However, for application requiring the tracking of an entire surface, such as quantifying cartilage contact kinematics, this combined imaging approach produces accurate results with minimal operator intervention.

  16. Understanding patellofemoral pain with maltracking in the presence of joint laxity: complete 3D in vivo patellofemoral and tibiofemoral kinematics.

    PubMed

    Sheehan, Frances T; Derasari, Aditya; Brindle, Timothy J; Alter, Katharine E

    2009-05-01

    Patellofemoral pain is widely accepted as one of the most common pathologies involving the knee, yet the etiology of this pain is still an open debate. Generalized joint laxity has been associated with patellofemoral pain, but is not often discussed as a potential source of patellar maltracking. Thus, the objective of this study was to compare the complete 6 degree of freedom patellofemoral and tibiofemoral kinematics from a group of patients diagnosed with patellofemoral pain syndrome and maltracking to those from an asymptomatic population. The following null hypotheses were tested: kinematic alterations in patellofemoral maltracking are limited to the axial plane; knee joint kinematics are the same in maltrackers with and without generalized joint laxity (defined by a clinical diagnosis of Ehlers Danlos Syndrome); and no correlations exist between tibiofemoral and patellofemoral kinematics or within patellofemoral kinematics. This study demonstrated that alterations in patellofemoral kinematics, associated with patellofemoral pain, are not limited to the axial plane, minimal correlations exist between patellofemoral and tibiofemoral kinematics, and distinct subgroups likely exist within the general population of maltrackers. Being able to identify subgroups correctly within the omnibus diagnosis of patellar maltracking is a crucial step in correctly defining the pathophysiology and the eventual treatment of these patients.

  17. Global and regional kinematics of the cervical spine during upper cervical spine manipulation: a reliability analysis of 3D motion data.

    PubMed

    Dugailly, Pierre-Michel; Beyer, Benoît; Sobczak, Stéphane; Salvia, Patrick; Feipel, Véronique

    2014-10-01

    Studies reporting spine kinematics during cervical manipulation are usually related to continuous global head-trunk motion or discrete angular displacements for pre-positioning. To date, segmental data analyzing continuous kinematics of cervical manipulation is lacking. The objective of this study was to investigate upper cervical spine (UCS) manipulation in vitro. This paper reports an inter- and intra-rater reliability analysis of kinematics during high velocity low amplitude manipulation of the UCS. Integration of kinematics into specific-subject 3D models has been processed as well for providing anatomical motion representation during thrust manipulation. Three unembalmed specimens were included in the study. Restricted dissection was realized to attach technical clusters to each bone of interest (skull, C1-C4 and sternum). During manipulation, bone motion data was computed using an optoelectronic system. The reliability of manipulation kinematics was assessed for three experimented practitioners performing two trials of 3 repetitions on two separate days. During UCS manipulation, average global head-trunk motion ROM (±SD) were 14 ± 5°, 35 ± 7° and 14 ± 8° for lateral bending, axial rotation and flexion-extension, respectively. For regional ROM (C0-C2), amplitudes were 10 ± 5°, 30 ± 5° and 16 ± 4° for the same respective motions. Concerning the reliability, mean RMS ranged from 1° to 4° and from 3° to 6° for intra- and inter-rater comparisons, respectively. The present results confirm the limited angular displacement during manipulation either for global head-trunk or for UCS motion components, especially for axial rotation. Additionally, kinematics variability was low confirming intra- and inter-practitioners consistency of UCS manipulation achievement.

  18. 3D kinematic measurement of human movement using low cost fish-eye cameras

    NASA Astrophysics Data System (ADS)

    Islam, Atiqul; Asikuzzaman, Md.; Garratt, Matthew A.; Pickering, Mark R.

    2017-02-01

    3D motion capture is difficult when the capturing is performed in an outdoor environment without controlled surroundings. In this paper, we propose a new approach of using two ordinary cameras arranged in a special stereoscopic configuration and passive markers on a subject's body to reconstruct the motion of the subject. Firstly for each frame of the video, an adaptive thresholding algorithm is applied for extracting the markers on the subject's body. Once the markers are extracted, an algorithm for matching corresponding markers in each frame is applied. Zhang's planar calibration method is used to calibrate the two cameras. As the cameras use the fisheye lens, they cannot be well estimated using a pinhole camera model which makes it difficult to estimate the depth information. In this work, to restore the 3D coordinates we use a unique calibration method for fisheye lenses. The accuracy of the 3D coordinate reconstruction is evaluated by comparing with results from a commercially available Vicon motion capture system.

  19. Performing Accurate Rigid Kinematics Measurements from 3D in vivo Image Sequences through Median Consensus Simultaneous Registration.

    PubMed

    Cresson, T; Jacq, J; Burdin, V; Roux, Ch

    2005-01-01

    While focusing at accurate 3D joint kinematics, this paper explores the problem of how to perform a robust rigid registration for a sequence of object surfaces observed using standard 3D medical imaging techniques. Each object instance is assumed to give access to a polyhedral encoding of its boundary. We consider the case where object instances are noised with significant truncations and segmentation errors. The proposed method aims to tackle this problem in a global way, fully exploiting the duality between redundancy and complementarity of the available instances set. The algorithm operates through robust and simultaneous registration of all geometrical instances on a virtual instance accounting for their median consensus. When compared with standard robust techniques, trials reveal significant gains, as much in robustness as in accuracy. The considered applications are mainly focused on generating highly accurate kinematics in relation to the bone structures of the most complex joints - the tarsus and the carpus - for which no alternative examination techniques exist, enabling fine morphological analysis as well as access to internal joint motions.

  20. Polyphase tertiary fold-and-thrust tectonics in the Belluno Dolomites: new mapping, kinematic analysis, and 3D modelling

    NASA Astrophysics Data System (ADS)

    Chistolini, Filippo; Bistacchi, Andrea; Massironi, Matteo; Consonni, Davide; Cortinovis, Silvia

    2014-05-01

    The Belluno Dolomites are comprised in the eastern sector of the Southern Alps, which corresponds to the fold-and-thrust belt at the retro-wedge of the Alpine collisional orogen. They are characterized by a complex and polyphase fold-and-thrust tectonics, highlighted by multiple thrust sheets and thrust-related folding. We have studied this tectonics in the Vajont area where a sequence of Jurassic, Cretaceous and Tertiary units have been involved in multiple deformations. The onset of contractional tectonics in this part of the Alps is constrained to be Tertiary (likely Post-Eocene) by structural relationships with the Erto Flysch, whilst in the Mesozoic tectonics was extensional. We have recognized two contractional deformation phases (D1 and D2 in the following), of which only the second was mentioned in previous studies of the area and attributed to the Miocene Neoalpine event. D1 and D2 are characterized by roughly top-to-WSW (possibly Dinaric) and top-to-S (Alpine) transport directions respectively, implying a 90° rotation of the regional-scale shortening axis, and resulting in complex thrust and fold interference and reactivation patterns. Geological mapping and detailed outcrop-scale kinematic analysis allowed us to characterize the kinematics and chronology of deformations. Particularly, relative chronology was unravelled thanks to (1) diagnostic fold interference patterns and (2) crosscutting relationships between thrust faults and thrust-related folds. A km-scale D1 syncline, filled with the Eocene Erto Flysch and "decapitated" by a D2 thrust fault, provides the best map-scale example of crosscutting relationships allowing to reconstruct the faulting history. Due to the strong competence contrast between Jurassic carbonates and Tertiary flysch, in this syncline spectacular duplexes were also developed during D2. In order to quantitatively characterize the complex interference pattern resulting from two orthogonal thrusting and folding events, we

  1. 3D Geometry and Kinematics of the Taiwan Arc-continent Collision

    NASA Astrophysics Data System (ADS)

    Carena, S.; Suppe, J.; Wu, Y. M.

    2015-12-01

    In Taiwan two subduction zones (Manila trench and Ryukyu trench) come together in a quasi-orthogonal, kinematically stable configuration. Subduction is ongoing in both trenches, even though the tectonic setting in the Manila trench is that of an arc-continent collision. The upper crust of Eurasia (EU) is decoupled from the rest of the lithosphere by a detachment horizon, which is the main subduction interface between EU and Philippine Sea plate (PSP). The interface is visible in both seismicity and crustal tomography at shallow depths, and it can be followed into the mantle to 450-500 km depth with global tomography. Shortening across the plate boundary is accomplished by a combination of subduction of EU lithosphere, folding and thrusting in the Eurasian upper crust, and a secondary subduction zone within the PSP. We hypothesize that: (1) once arc-continent collision occurs, subduction of Eurasian continental lower crust and upper mantle can continue by lithospheric delamination and by continuity with the much larger Eurasian slab to the south; (2) the upper crust of EU deforms by faulting and folding; (3) the present convergence rate of about 90 mm/yr is limited at most to the last 2 Ma, whereas the long-term rate is about 30 mm/yr and in Taiwan the difference is being taken up by secondary subduction within the PSP margin; (4) a margin-parallel STEP (Subduction-Transform-Edge-Propagator) fault forms the northern limit of Eurasian subduction, which allows the whole system to propagate self-similarly southwestward. No slab breakoff is required for the kinematics of the margin, and none is observed in geophysical or geological data either. This kinematics is consistent with geologic observations: from timing of opening of the southern Okinawa trough, to geometry of geologic boundaries within the Taiwan mountain belt, to geographic distribution, geochemical character, and timing of Quaternary volcanism in the northern Taiwan volcanic zone. We constrained the long

  2. Automated kinematic modelling of warped galaxy discs in large H I surveys: 3D tilted-ring fitting of H I emission cubes

    NASA Astrophysics Data System (ADS)

    Kamphuis, P.; Józsa, G. I. G.; Oh, S.-. H.; Spekkens, K.; Urbancic, N.; Serra, P.; Koribalski, B. S.; Dettmar, R.-J.

    2015-09-01

    Kinematical parametrizations of disc galaxies, employing emission line observations, are indispensable tools for studying the formation and evolution of galaxies. Future large-scale H I surveys will resolve the discs of many thousands of galaxies, allowing a statistical analysis of their disc and halo kinematics, mass distribution and dark matter content. Here, we present an automated procedure which fits tilted-ring models to H I data cubes of individual, well-resolved galaxies. The method builds on the 3D Tilted Ring Fitting Code (TIRIFIC) and is called Fully Automated TIRIFIC (FAT). To assess the accuracy of the code, we apply it to a set of 52 artificial galaxies and 25 real galaxies from the Local Volume H I Survey (LVHIS). Using LVHIS data, we compare our 3D modelling to the 2D modelling methods DISKFIT and ROTCUR. A conservative result is that FAT accurately models the kinematics and the morphologies of galaxies with an extent of eight beams across the major axis in the inclination range 20°-90° without the need for priors such as disc inclination. When comparing to 2D methods we find that velocity fields cannot be used to determine inclinations in galaxies that are marginally resolved. We conclude that with the current code tilted-ring models can be produced in a fully automated fashion. This will be essential for future H I surveys, with the Square Kilometre Array and its pathfinders, which will allow us to model the gas kinematics of many thousands of well-resolved galaxies. Performance studies of FAT close to our conservative limits, as well as the introduction of more parametrized models will open up the possibility to study even less resolved galaxies.

  3. Kinematic analysis of healthy hips during weight-bearing activities by 3D-to-2D model-to-image registration technique.

    PubMed

    Hara, Daisuke; Nakashima, Yasuharu; Hamai, Satoshi; Higaki, Hidehiko; Ikebe, Satoru; Shimoto, Takeshi; Hirata, Masanobu; Kanazawa, Masayuki; Kohno, Yusuke; Iwamoto, Yukihide

    2014-01-01

    Dynamic hip kinematics during weight-bearing activities were analyzed for six healthy subjects. Continuous X-ray images of gait, chair-rising, squatting, and twisting were taken using a flat panel X-ray detector. Digitally reconstructed radiographic images were used for 3D-to-2D model-to-image registration technique. The root-mean-square errors associated with tracking the pelvis and femur were less than 0.3 mm and 0.3° for translations and rotations. For gait, chair-rising, and squatting, the maximum hip flexion angles averaged 29.6°, 81.3°, and 102.4°, respectively. The pelvis was tilted anteriorly around 4.4° on average during full gait cycle. For chair-rising and squatting, the maximum absolute value of anterior/posterior pelvic tilt averaged 12.4°/11.7° and 10.7°/10.8°, respectively. Hip flexion peaked on the way of movement due to further anterior pelvic tilt during both chair-rising and squatting. For twisting, the maximum absolute value of hip internal/external rotation averaged 29.2°/30.7°. This study revealed activity dependent kinematics of healthy hip joints with coordinated pelvic and femoral dynamic movements. Kinematics' data during activities of daily living may provide important insight as to the evaluating kinematics of pathological and reconstructed hips.

  4. Evaluation of the Kinect™ sensor for 3-D kinematic measurement in the workplace.

    PubMed

    Dutta, Tilak

    2012-07-01

    Recording posture and movement is important for determining risk of musculoskeletal injury in the workplace, but existing motion capture systems are not suited for field work. Estimates of the 3-D relative positions of four 0.10 m cubes from the Kinect were compared to estimates from a Vicon motion capture system to determine whether the hardware sensing components were sensitive enough to be used as a portable 3-D motion capture system for workplace ergonomic assessments. The root-mean-squared errors (SD) were 0.0065 m (0.0048 m), 0.0109 m (0.0059 m), 0.0057 m (0.0042 m) in the x, y and z directions (with x axis to the right, y axis away from the sensor and z axis upwards). These data were collected over a range of 1.0-3.0m from the device covering a field of view of 54.0 degrees horizontally and 39.1 degrees vertically. Requirements for software, hardware and subject preparation were also considered to determine the usability of the Kinect in the field.

  5. In Vivo Kinematics of the Anterior Cruciate Ligament Deficient Knee During Wide-Based Squat Using a 2D/3D Registration Technique.

    PubMed

    Miyaji, Takeshi; Gamada, Kazuyoshi; Kidera, Kenichi; Ikuta, Futoshi; Yoneta, Kei; Shindo, Hiroyuki; Osaki, Makoto; Yonekura, Akihiko

    2012-01-01

    Anterior cruciate ligament (ACL) deficiency increases the risk of early osteoarthritis (OA). Studies of ACL deficient knee kinematics would be important to reveal the disease process and therefore to find mechanisms which would potentially slow OA progression. The purpose of this study was to determine if in vivo kinematics of the anterior cruciate ligament deficient (ACLD) knee during a wide-based squat activity differ from kinematics of the contralateral intact knee. Thirty-three patients with a unilateral ACLD knee consented to participate in this institutional review board approved study with the contralateral intact knee serving as the control. In vivo knee kinematics during the wide-based squat were analyzed using a 2D/3D registration technique utilizing CT-based bone models and lateral fluoroscopy. Comparisons were performed using values between 0 and 100° flexion both in flexion and extension phases of the squat activity. Both the ACLD and intact knees demonstrated increasing tibial internal rotation with knee flexion, and no difference was observed in tibial rotation between the groups. The tibia in the ACLD knee was more anterior than that of the contralateral knees at 0 and 5° flexion in both phases (p < 0.05). Tibiofemoral medial contact points of the ACLD knees were more posterior than that of the contralateral knees at 5, 10 and 15° of knee flexion in the extension phase of the squat activity (p < 0.05). Tibiofemoral lateral contact points of the ACLD knees were more posterior than that of the contralateral knees at 0° flexion in the both phases (p < 0.05). The kinematics of the ACLD and contralateral intact knees were similar during the wide-based squat except at the low flexion angles. Therefore, we conclude the wide-based squat may be recommended for the ACLD knee by avoiding terminal extension.

  6. 2D vs. 3D mammography observer study

    NASA Astrophysics Data System (ADS)

    Fernandez, James Reza F.; Hovanessian-Larsen, Linda; Liu, Brent

    2011-03-01

    Breast cancer is the most common type of non-skin cancer in women. 2D mammography is a screening tool to aid in the early detection of breast cancer, but has diagnostic limitations of overlapping tissues, especially in dense breasts. 3D mammography has the potential to improve detection outcomes by increasing specificity, and a new 3D screening tool with a 3D display for mammography aims to improve performance and efficiency as compared to 2D mammography. An observer study using a mammography phantom was performed to compare traditional 2D mammography with this ne 3D mammography technique. In comparing 3D and 2D mammography there was no difference in calcification detection, and mass detection was better in 2D as compared to 3D. There was a significant decrease in reading time for masses, calcifications, and normals in 3D compared to 2D, however, as well as more favorable confidence levels in reading normal cases. Given the limitations of the mammography phantom used, however, a clearer picture in comparing 3D and 2D mammography may be better acquired with the incorporation of human studies in the future.

  7. Image based 3D city modeling : Comparative study

    NASA Astrophysics Data System (ADS)

    Singh, S. P.; Jain, K.; Mandla, V. R.

    2014-06-01

    3D city model is a digital representation of the Earth's surface and it's related objects such as building, tree, vegetation, and some manmade feature belonging to urban area. The demand of 3D city modeling is increasing rapidly for various engineering and non-engineering applications. Generally four main image based approaches were used for virtual 3D city models generation. In first approach, researchers were used Sketch based modeling, second method is Procedural grammar based modeling, third approach is Close range photogrammetry based modeling and fourth approach is mainly based on Computer Vision techniques. SketchUp, CityEngine, Photomodeler and Agisoft Photoscan are the main softwares to represent these approaches respectively. These softwares have different approaches & methods suitable for image based 3D city modeling. Literature study shows that till date, there is no complete such type of comparative study available to create complete 3D city model by using images. This paper gives a comparative assessment of these four image based 3D modeling approaches. This comparative study is mainly based on data acquisition methods, data processing techniques and output 3D model products. For this research work, study area is the campus of civil engineering department, Indian Institute of Technology, Roorkee (India). This 3D campus acts as a prototype for city. This study also explains various governing parameters, factors and work experiences. This research work also gives a brief introduction, strengths and weakness of these four image based techniques. Some personal comment is also given as what can do or what can't do from these softwares. At the last, this study shows; it concluded that, each and every software has some advantages and limitations. Choice of software depends on user requirements of 3D project. For normal visualization project, SketchUp software is a good option. For 3D documentation record, Photomodeler gives good result. For Large city

  8. M3D project for simulation studies of plasmas

    SciTech Connect

    Park, W.; Belova, E.V.; Fu, G.Y.; Strauss, H.R.; Sugiyama, L.E.

    1998-12-31

    The M3D (Multi-level 3D) project carries out simulation studies of plasmas of various regimes using multi-levels of physics, geometry, and mesh schemes in one code package. This paper and papers by Strauss, Sugiyama, and Belova in this workshop describe the project, and present examples of current applications. The currently available physics models of the M3D project are MHD, two-fluids, gyrokinetic hot particle/MHD hybrid, and gyrokinetic particle ion/two-fluid hybrid models. The code can be run with both structured and unstructured meshes.

  9. True 3D kinematic analysis for slope instability assessment in the Siq of Petra (Jordan), from high resolution TLS

    NASA Astrophysics Data System (ADS)

    Gigli, Giovanni; Margottini, Claudio; Spizzichino, Daniele; Ruther, Heinz; Casagli, Nicola

    2016-04-01

    released, stratigraphic setting and tectonic activity can be recognized. As a consequence, rock-falls have been occurring, even recently, with unstable rock mass volumes ranging from 0.1 m3 up to over some hundreds m3. Slope instability, acceleration of crack deformation and consequent increasing of rock-fall hazard conditions, could threaten the safety of tourist as well as the integrity of the heritage. 3D surface model coming from Terrestrial Laser Scanner acquisitions was developed almost all over the site of Petra, including the Siq. Comprehensively, a point cloud of five billion points was generated making the site of Petra likely the largest scanned archaeological site in the word. As far as the Siq, the scanner was positioned on the path floor at intervals of not more than 10 meters from each station. The total number of scans in the Siq was 220 with an average point cloud interval of approximately 3 cm. Subsequently, for the definition of the main rockfall source areas, a spatial kinematic analysis for the whole Siq has been performed, by using discontinuity orientation data extracted from the point cloud by means of the software Diana. Orientation, number of sets, spacing/frequency, persistence, block size and scale dependent roughness was obtained combining fieldwork and automatic analysis. This kind of analysis is able to establish where a particular instability mechanism is kinematically feasible, given the geometry of the slope, the orientation of discontinuities and shear strength of the rock. The final outcome of this project was a detail landslide kinematic index map, reporting main potential instability mechanisms for a given area. The kinematic index was finally calibrated for each instability mechanism (plane failure; wedge failure; block toppling; flexural toppling) surveyed in the site. The latter is including the collapse occurred in May 2015, likely not producing any victim, in a sector clearly identified by the susceptibility maps produced by the

  10. Autonomous surgical robotics using 3-D ultrasound guidance: feasibility study.

    PubMed

    Whitman, John; Fronheiser, Matthew P; Ivancevich, Nikolas M; Smith, Stephen W

    2007-10-01

    The goal of this study was to test the feasibility of using a real-time 3D (RT3D) ultrasound scanner with a transthoracic matrix array transducer probe to guide an autonomous surgical robot. Employing a fiducial alignment mark on the transducer to orient the robot's frame of reference and using simple thresholding algorithms to segment the 3D images, we tested the accuracy of using the scanner to automatically direct a robot arm that touched two needle tips together within a water tank. RMS measurement error was 3.8% or 1.58 mm for an average path length of 41 mm. Using these same techniques, the autonomous robot also performed simulated needle biopsies of a cyst-like lesion in a tissue phantom. This feasibility study shows the potential for 3D ultrasound guidance of an autonomous surgical robot for simple interventional tasks, including lesion biopsy and foreign body removal.

  11. A Preliminary Study of 3D Printing on Rock Mechanics

    NASA Astrophysics Data System (ADS)

    Jiang, Chao; Zhao, Gao-Feng

    2015-05-01

    3D printing is an innovative manufacturing technology that enables the printing of objects through the accumulation of successive layers. This study explores the potential application of this 3D printing technology for rock mechanics. Polylactic acid (PLA) was used as the printing material, and the specimens were constructed with a "3D Touch" printer that employs fused deposition modelling (FDM) technology. Unconfined compressive strength (UCS) tests and direct tensile strength (DTS) tests were performed to determine the Young's modulus ( E) and Poisson's ratio ( υ) for these specimens. The experimental results revealed that the PLA specimens exhibited elastic to brittle behaviour in the DTS tests and exhibited elastic to plastic behaviour in the UCS tests. The influence of structural changes in the mechanical response of the printed specimen was investigated; the results indicated that the mechanical response is highly influenced by the input structures, e.g., granular structure, and lattice structure. Unfortunately, our study has demonstrated that the FDM 3D printing with PLA is unsuitable for the direct simulation of rock. However, the ability for 3D printing on manufactured rock remains appealing for researchers of rock mechanics. Additional studies should focus on the development of an appropriate substitution for the printing material (brittle and stiff) and modification of the printing technology (to print 3D grains with arbitrary shapes).

  12. NGT-3D: a simple nematode cultivation system to study Caenorhabditis elegans biology in 3D

    PubMed Central

    Lee, Tong Young; Yoon, Kyoung-hye; Lee, Jin Il

    2016-01-01

    ABSTRACT The nematode Caenorhabditis elegans is one of the premier experimental model organisms today. In the laboratory, they display characteristic development, fertility, and behaviors in a two dimensional habitat. In nature, however, C. elegans is found in three dimensional environments such as rotting fruit. To investigate the biology of C. elegans in a 3D controlled environment we designed a nematode cultivation habitat which we term the nematode growth tube or NGT-3D. NGT-3D allows for the growth of both nematodes and the bacteria they consume. Worms show comparable rates of growth, reproduction and lifespan when bacterial colonies in the 3D matrix are abundant. However, when bacteria are sparse, growth and brood size fail to reach levels observed in standard 2D plates. Using NGT-3D we observe drastic deficits in fertility in a sensory mutant in 3D compared to 2D, and this defect was likely due to an inability to locate bacteria. Overall, NGT-3D will sharpen our understanding of nematode biology and allow scientists to investigate questions of nematode ecology and evolutionary fitness in the laboratory. PMID:26962047

  13. NGT-3D: a simple nematode cultivation system to study Caenorhabditis elegans biology in 3D.

    PubMed

    Lee, Tong Young; Yoon, Kyoung-Hye; Lee, Jin Il

    2016-04-15

    The nematodeCaenorhabditiselegansis one of the premier experimental model organisms today. In the laboratory, they display characteristic development, fertility, and behaviors in a two dimensional habitat. In nature, however,C. elegansis found in three dimensional environments such as rotting fruit. To investigate the biology ofC. elegansin a 3D controlled environment we designed a nematode cultivation habitat which we term the nematode growth tube or NGT-3D. NGT-3D allows for the growth of both nematodes and the bacteria they consume. Worms show comparable rates of growth, reproduction and lifespan when bacterial colonies in the 3D matrix are abundant. However, when bacteria are sparse, growth and brood size fail to reach levels observed in standard 2D plates. Using NGT-3D we observe drastic deficits in fertility in a sensory mutant in 3D compared to 2D, and this defect was likely due to an inability to locate bacteria. Overall, NGT-3D will sharpen our understanding of nematode biology and allow scientists to investigate questions of nematode ecology and evolutionary fitness in the laboratory.

  14. In vivo 3D analysis of clavicular kinematics during scapular plane abduction: comparison of dominant and non-dominant shoulders.

    PubMed

    Matsuki, Keisuke; Matsuki, Kei O; Mu, Shang; Kenmoku, Tomonori; Yamaguchi, Satoshi; Ochiai, Nobuyasu; Sasho, Takahisa; Sugaya, Hiroyuki; Toyone, Tomoaki; Wada, Yuichi; Takahashi, Kazuhisa; Banks, Scott A

    2014-01-01

    The purpose of this study was to evaluate side-to-side differences in three-dimensional clavicle kinematics in normal shoulders during dynamic scapular plane elevation using model-image registration techniques. Twelve healthy males with a mean age of 32 years (range, 27-36 years old) were enrolled in this study. Clavicle rotations were computed with bilateral fluoroscopic images and CT-derived bone models using model-image registration techniques and compared between dominant and nondominant shoulders. There was no difference in retraction between both shoulders. The clavicle in dominant shoulders was less elevated during abduction than in nondominant shoulders (P=0.03). Backward rotation angles of dominant shoulders were significantly smaller than those of nondominant shoulders throughout the activity (P=0.03). Clavicular kinematics during scapular plane abduction were different according to hand-dominance.

  15. Study of capabilities and limitations of 3D printing technology

    NASA Astrophysics Data System (ADS)

    Lemu, H. G.

    2012-04-01

    3D printing is one of the developments in rapid prototyping technology. The inception and development of the technology has highly assisted the product development phase of product design and manufacturing. The technology is particularly important in educating product design and 3D modeling because it helps students to visualize their design idea, to enhance their creative design process and enables them to touch and feel the result of their innovative work. The availability of many 3D printers on the market has created a certain level of challenge for the user. Among others, complexity of part geometry, material type, compatibility with 3D CAD models and other technical aspects still need in-depth study. This paper presents results of the experimental work on the capabilities and limitations of the Z510 3D printer from Z-corporation. Several parameters such as dimensional and geometrical accuracy, surface quality and strength as a function of model size, orientation and file exchange format are closely studied.

  16. An intelligent recovery progress evaluation system for ACL reconstructed subjects using integrated 3-D kinematics and EMG features.

    PubMed

    Malik, Owais A; Senanayake, S M N Arosha; Zaheer, Dansih

    2015-03-01

    An intelligent recovery evaluation system is presented for objective assessment and performance monitoring of anterior cruciate ligament reconstructed (ACL-R) subjects. The system acquires 3-D kinematics of tibiofemoral joint and electromyography (EMG) data from surrounding muscles during various ambulatory and balance testing activities through wireless body-mounted inertial and EMG sensors, respectively. An integrated feature set is generated based on different features extracted from data collected for each activity. The fuzzy clustering and adaptive neuro-fuzzy inference techniques are applied to these integrated feature sets in order to provide different recovery progress assessment indicators (e.g., current stage of recovery, percentage of recovery progress as compared to healthy group, etc.) for ACL-R subjects. The system was trained and tested on data collected from a group of healthy and ACL-R subjects. For recovery stage identification, the average testing accuracy of the system was found above 95% (95-99%) for ambulatory activities and above 80% (80-84%) for balance testing activities. The overall recovery evaluation performed by the proposed system was found consistent with the assessment made by the physiotherapists using standard subjective/objective scores. The validated system can potentially be used as a decision supporting tool by physiatrists, physiotherapists, and clinicians for quantitative rehabilitation analysis of ACL-R subjects in conjunction with the existing recovery monitoring systems.

  17. Jurassic extension and Cenozoic inversion tectonics in the Asturian Basin, NW Iberian Peninsula: 3D structural model and kinematic evolution

    NASA Astrophysics Data System (ADS)

    Uzkeda, Hodei; Bulnes, Mayte; Poblet, Josep; García-Ramos, José Carlos; Piñuela, Laura

    2016-09-01

    We constructed a geological map, a 3D model and cross-sections, carried out a structural analysis, determined the stress fields and tectonic transport vectors, restored a cross section and performed a subsidence analysis to unravel the kinematic evolution of the NE emerged portion of the Asturian Basin (NW Iberian Peninsula), where Jurassic rocks crop out. The major folds run NW-SE, normal faults exhibit three dominant orientations: NW-SE, NE-SW and E-W, and thrusts display E-W strikes. After Upper Triassic-Lower Jurassic thermal subsidence, Middle Jurassic doming occurred, accompanied by normal faulting, high heat flow and basin uplift, followed by Upper Jurassic high-rate basin subsidence. Another extensional event, possibly during Late Jurassic-Early Cretaceous, caused an increment in the normal faults displacement. A contractional event, probably of Cenozoic age, led to selective and irregularly distributed buttressing and fault reactivation as reverse or strike-slip faults, and folding and/or offset of some previous faults by new generation folds and thrusts. The Middle Jurassic event could be a precursor of the Bay of Biscay and North Atlantic opening that occurred from Late Jurassic to Early Cretaceous, whereas the Cenozoic event would be responsible for the Pyrenean and Cantabrian ranges and the partial closure of the Bay of Biscay.

  18. 3D Geo-Information in Urban Climate Studies

    NASA Astrophysics Data System (ADS)

    Petrescu, F.; Aldea, M.; Luca, O.; Iacoboaea, C.; Gaman, F.; Parlow, E.

    2016-10-01

    3D geo-information is essential for urban climate studies. It is obvious that both natural environment and built-up environment play the fundamental role in defining the climatic conditions for urban areas, which affect the quality of human life and human comfort. The paper presents the main categories of 3D geo-information used in urban climate studies and roles in creating and operating the numerical models specially designed to simulate urban planning scenarios and improvement of the urban climate situation.

  19. Photogrammetric 3D skull/photo superimposition: A pilot study.

    PubMed

    Santoro, Valeria; Lubelli, Sergio; De Donno, Antonio; Inchingolo, Alessio; Lavecchia, Fulvio; Introna, Francesco

    2017-04-01

    The identification of bodies through the examination of skeletal remains holds a prominent place in the field of forensic investigations. Technological advancements in 3D facial acquisition techniques have led to the proposal of a new body identification technique that involves a combination of craniofacial superimposition and photogrammetry. The aim of this study was to test the method by superimposing various computerized 3D images of skulls onto various photographs of missing people taken while they were still alive in cases when there was a suspicion that the skulls in question belonged to them. The technique is divided into four phases: preparatory phase, 3d acquisition phase, superimposition phase, and metric image analysis 3d. The actual superimposition of the images was carried out in the fourth step. and was done so by comparing the skull images with the selected photos. Using a specific software, the two images (i.e. the 3D avatar and the photo of the missing person) were superimposed. Cross-comparisons of 5 skulls discovered in a mass grave, and of 2 skulls retrieved in the crawlspace of a house were performed. The morphologyc phase reveals a full overlap between skulls and photos of disappeared persons. Metric phase reveals that correlation coefficients of this values, higher than 0.998-0,997 allow to confirm identification hypothesis.

  20. Case study: The Avengers 3D: cinematic techniques and digitally created 3D

    NASA Astrophysics Data System (ADS)

    Clark, Graham D.

    2013-03-01

    Marvel's THE AVENGERS was the third film Stereo D collaborated on with Marvel; it was a summation of our artistic development of what Digitally Created 3D and Stereo D's artists and toolsets affords Marvel's filmmakers; the ability to shape stereographic space to support the film and story, in a way that balances human perception and live photography. We took our artistic lead from the cinematic intentions of Marvel, the Director Joss Whedon, and Director of Photography Seamus McGarvey. In the digital creation of a 3D film from a 2D image capture, recommendations to the filmmakers cinematic techniques are offered by Stereo D at each step from pre-production onwards, through set, into post. As the footage arrives at our facility we respond in depth to the cinematic qualities of the imagery in context of the edit and story, with the guidance of the Directors and Studio, creating stereoscopic imagery. Our involvement in The Avengers was early in production, after reading the script we had the opportunity and honor to meet and work with the Director Joss Whedon, and DP Seamus McGarvey on set, and into post. We presented what is obvious to such great filmmakers in the ways of cinematic techniques as they related to the standard depth cues and story points we would use to evaluate depth for their film. Our hope was any cinematic habits that supported better 3D would be emphasized. In searching for a 3D statement for the studio and filmmakers we arrived at a stereographic style that allowed for comfort and maximum visual engagement to the viewer.

  1. Enigmatic structures within salt walls of the Santos Basin-Part 1: Geometry and kinematics from 3D seismic reflection and well data

    NASA Astrophysics Data System (ADS)

    Jackson, Christopher A.-L.; Jackson, Martin P. A.; Hudec, Michael R.; Rodriguez, Clara R.

    2015-06-01

    Understanding intrasalt structure may elucidate the fundamental kinematics and, ultimately, the mechanics of diapir growth. However, there have been relatively few studies of the internal structure of salt diapirs outside the mining industry because their cores are only partly exposed in the field and poorly imaged on seismic reflection data. This study uses 3D seismic reflection and borehole data from the São Paulo Plateau, Santos Basin, offshore Brazil to document the variability in intrasalt structural style in natural salt diapirs. We document a range of intrasalt structures that record: (i) initial diapir rise; (ii) rise of lower mobile halite through an arched and thinned roof of denser, layered evaporites, and emplacement of an intrasalt sheet or canopy; (iii) formation of synclinal flaps kinematically linked to emplacement of the intrasalt allochthonous bodies; and (iv) diapir squeezing. Most salt walls contain simple internal anticlines. Only a few salt walls contain allochthonous bodies and breakout-related flaps. The latter occur in an area having a density inversion within the autochthonous salt layer, such that upper, anhydrite-rich, layered evaporites are denser than lower, more halite-rich evaporites. We thus interpret that most diapirs rose through simple fold amplification of internal salt stratigraphy but that locally, where a density inversion existed in the autochthonous salt, Rayleigh-Taylor overturn within the growing diapir resulted in the ascent of less dense evaporites into the diapir crest by breaching of the internal anticline. This resulted in the formation of steep salt-ascension zones or feeders and the emplacement of high-level intrasalt allocthonous sheets underlain by breakout-related flaps. Although regional shortening undoubtedly occurred on the São Paulo Plateau during the Late Cretaceous, we suggest this was only partly responsible for the complex intrasalt deformation. We suggest that, although based on the Santos Basin, our

  2. Studies of the 3D surface roughness height

    SciTech Connect

    Avisane, Anita; Rudzitis, Janis; Kumermanis, Maris

    2013-12-16

    Nowadays nano-coatings occupy more and more significant place in technology. Innovative, functional coatings acquire new aspects from the point of view of modern technologies, considering the aggregate of physical properties that can be achieved manipulating in the production process with the properties of coatings’ surfaces on micro- and nano-level. Nano-coatings are applied on machine parts, friction surfaces, contacting parts, corrosion surfaces, transparent conducting films (TCF), etc. The equipment available at present for the production of transparent conducting oxide (TCO) coatings with highest quality is based on expensive indium tin oxide (ITO) material; therefore cheaper alternatives are being searched for. One such offered alternative is zink oxide (ZnO) nano-coatings. Evaluating the TCF physical and mechanical properties and in view of the new ISO standard (EN ISO 25178) on the introduction of surface texture (3D surface roughness) in the engineering calculations, it is necessary to examine the height of 3D surface roughness, which is one of the most significant roughness parameters. The given paper studies the average values of 3D surface roughness height and the most often applied distribution laws are as follows: the normal distribution and Rayleigh distribution. The 3D surface is simulated by a normal random field.

  3. Numerical study on 3D composite morphing actuators

    NASA Astrophysics Data System (ADS)

    Oishi, Kazuma; Saito, Makoto; Anandan, Nishita; Kadooka, Kevin; Taya, Minoru

    2015-04-01

    There are a number of actuators using the deformation of electroactive polymer (EAP), where fewer papers seem to have focused on the performance of 3D morphing actuators based on the analytical approach, due mainly to their complexity. The present paper introduces a numerical analysis approach on the large scale deformation and motion of a 3D half dome shaped actuator composed of thin soft membrane (passive material) and EAP strip actuators (EAP active coupon with electrodes on both surfaces), where the locations of the active EAP strips is a key parameter. Simulia/Abaqus Static and Implicit analysis code, whose main feature is the high precision contact analysis capability among structures, are used focusing on the whole process of the membrane to touch and wrap around the object. The unidirectional properties of the EAP coupon actuator are used as input data set for the material properties for the simulation and the verification of our numerical model, where the verification is made as compared to the existing 2D solution. The numerical results can demonstrate the whole deformation process of the membrane to wrap around not only smooth shaped objects like a sphere or an egg, but also irregularly shaped objects. A parametric study reveals the proper placement of the EAP coupon actuators, with the modification of the dome shape to induce the relevant large scale deformation. The numerical simulation for the 3D soft actuators shown in this paper could be applied to a wider range of soft 3D morphing actuators.

  4. Construction of semi-dynamic model of subduction zone with given plate kinematics in 3D sphere

    NASA Astrophysics Data System (ADS)

    Morishige, M.; Honda, S.; Tackley, P. J.

    2010-09-01

    We present a semi-dynamic subduction zone model in a three-dimensional spherical shell. In this model, velocity is imposed on the top surface and in a small three-dimensional region around the shallow plate boundary while below this region, the slab is able to subduct under its own weight. Surface plate velocities are given by Euler's theorem of rigid plate rotation on a sphere. The velocity imposed in the region around the plate boundary is determined so that mass conservation inside the region is satisfied. A kinematic trench migration can be easily incorporated in this model. As an application of this model, mantle flow around slab edges is considered, and we find that the effect of Earth curvature is small by comparing our model with a similar one in a rectangular box, at least for the parameters used in this study. As a second application of the model, mantle flow around a plate junction is studied, and we find the existence of mantle return flow perpendicular to the plate boundary. Since this model can naturally incorporate the spherical geometry and plate movement on the sphere, it is useful for studying a specific subduction zone where the plate kinematics is well constrained.

  5. 3D Regression Heat Map Analysis of Population Study Data.

    PubMed

    Klemm, Paul; Lawonn, Kai; Glaßer, Sylvia; Niemann, Uli; Hegenscheid, Katrin; Völzke, Henry; Preim, Bernhard

    2016-01-01

    Epidemiological studies comprise heterogeneous data about a subject group to define disease-specific risk factors. These data contain information (features) about a subject's lifestyle, medical status as well as medical image data. Statistical regression analysis is used to evaluate these features and to identify feature combinations indicating a disease (the target feature). We propose an analysis approach of epidemiological data sets by incorporating all features in an exhaustive regression-based analysis. This approach combines all independent features w.r.t. a target feature. It provides a visualization that reveals insights into the data by highlighting relationships. The 3D Regression Heat Map, a novel 3D visual encoding, acts as an overview of the whole data set. It shows all combinations of two to three independent features with a specific target disease. Slicing through the 3D Regression Heat Map allows for the detailed analysis of the underlying relationships. Expert knowledge about disease-specific hypotheses can be included into the analysis by adjusting the regression model formulas. Furthermore, the influences of features can be assessed using a difference view comparing different calculation results. We applied our 3D Regression Heat Map method to a hepatic steatosis data set to reproduce results from a data mining-driven analysis. A qualitative analysis was conducted on a breast density data set. We were able to derive new hypotheses about relations between breast density and breast lesions with breast cancer. With the 3D Regression Heat Map, we present a visual overview of epidemiological data that allows for the first time an interactive regression-based analysis of large feature sets with respect to a disease.

  6. Improving stall design: use of 3-D kinematics to measure space use by dairy cows when lying down.

    PubMed

    Ceballos, A; Sanderson, D; Rushen, J; Weary, D M

    2004-07-01

    Uncomfortable stalls reduce the time cows spend resting and are a risk factor for lameness. Although recommendations for stall dimensions are available, little research supports these recommendations. In this study, kinematic techniques were used to provide the first accurate measures of space used by Holstein dairy cows during lying-down movements in an open space and in a free stall. Cows (n=5, mean parity 3.2 +/- 1.0, body weight=607 +/- 21 kg) used up to 300 cm of longitudinal space when lying down, more than is typically provided by current industry recommendations for stall length. Cows used up to 109 cm of lateral space (180% of hip width), an estimate that is within current recommendations for stall width. During the lying-down movement, maximal lateral displacements at the hip occurred in two vertical zones: one between 95 and 135 cm, and the second less than 50 cm above the lying surface. Maximal longitudinal displacements of the nose were clustered 10 to 30 cm above the surface. These heights should be taken into account when designing and positioning stall partitions. Maximum instantaneous velocity of body markers approached 220 cm/s, indicating that cows can contact inappropriately placed stall partitions and the lying surface with considerable force. Kinematic techniques are promising ways of assessing spatial requirements of cattle to improve stall design. Further work is required to assess a wider range of cow sizes and stall configurations.

  7. Gait pattern in myotonic dystrophy (Steinert disease): a kinematic, kinetic and EMG evaluation using 3D gait analysis.

    PubMed

    Galli, Manuela; Cimolin, Veronica; Crugnola, Veronica; Priano, Lorenzo; Menegoni, Francesco; Trotti, Claudio; Milano, Eva; Mauro, Alessandro

    2012-03-15

    We investigated the gait pattern of 10 patients with myotonic dystrophy (Steinert disease; 4 females, 6 males; age: 41.5+7.6 years), compared to 20 healthy controls, through manual muscle test and gait analysis, in terms of kinematic, kinetic and EMG data. In most of patients (80%) distal muscle groups were weaker than proximal ones. Weakness at lower limbs was in general moderate to severe and MRC values evidenced a significant correlation between tibialis anterior and gastrocnemius medialis (R=0.91). An overall observation of gait pattern in patients when compared to controls showed that most spatio-temporal parameters (velocity, step length and cadence) were significantly different. As concerns kinematics, patients' pelvic tilt was globally in a higher position than control group, with reduced hip extension ability in stance phase and limited range of motion; 60% of the limbs revealed knee hyperextension during midstance and ankle joints showed a quite physiological position at initial contact and higher dorsiflexion during stance phase if compared to healthy individuals. Kinetic plots evidenced higher hip power during loading response and lower ankle power generation in terminal stance. The main EMG abnormalities were seen in tibialis anterior and gastrocnemius medialis muscles. In this study gait analysis gives objective and quantitative information about the gait pattern and the deviations due to the muscular situation of these patients; these results are important from a clinical point of view and suggest that rehabilitation programs for them should take these findings into account.

  8. Method and simulation to study 3D crosstalk perception

    NASA Astrophysics Data System (ADS)

    Khaustova, Dar'ya; Blondé, Laurent; Huynh-Thu, Quan; Vienne, Cyril; Doyen, Didier

    2012-03-01

    To various degrees, all modern 3DTV displays suffer from crosstalk, which can lead to a decrease of both visual quality and visual comfort, and also affect perception of depth. In the absence of a perfect 3D display technology, crosstalk has to be taken into account when studying perception of 3D stereoscopic content. In order to improve 3D presentation systems and understand how to efficiently eliminate crosstalk, it is necessary to understand its impact on human perception. In this paper, we present a practical method to study the perception of crosstalk. The approach consists of four steps: (1) physical measurements of a 3DTV, (2) building of a crosstalk surface based on those measurements and representing specifically the behavior of that 3TV, (3) manipulation of the crosstalk function and application on reference images to produce test images degraded by crosstalk in various ways, and (4) psychophysical tests. Our approach allows both a realistic representation of the behavior of a 3DTV and the easy manipulation of its resulting crosstalk in order to conduct psycho-visual experiments. Our approach can be used in all studies requiring the understanding of how crosstalk affects perception of stereoscopic content and how it can be corrected efficiently.

  9. THE KMOS{sup 3D} SURVEY: DESIGN, FIRST RESULTS, AND THE EVOLUTION OF GALAXY KINEMATICS FROM 0.7 ≤ z ≤ 2.7

    SciTech Connect

    Wisnioski, E.; Förster Schreiber, N. M.; Wuyts, S.; Wuyts, E.; Bandara, K.; Genzel, R.; Bender, R.; Davies, R.; Lang, P.; Mendel, J. T.; Beifiori, A.; Chan, J.; Fabricius, M.; Fudamoto, Y.; Kulkarni, S.; Kurk, J.; Lutz, D.; Wilman, D.; Fossati, M.; Brammer, G.; and others

    2015-02-01

    We present the KMOS{sup 3D} survey, a new integral field survey of over 600 galaxies at 0.7 < z < 2.7 using KMOS at the Very Large Telescope. The KMOS{sup 3D} survey utilizes synergies with multi-wavelength ground- and space-based surveys to trace the evolution of spatially resolved kinematics and star formation from a homogeneous sample over 5 Gyr of cosmic history. Targets, drawn from a mass-selected parent sample from the 3D-HST survey, cover the star formation-stellar mass (M {sub *}) and rest-frame (U – V) – M {sub *} planes uniformly. We describe the selection of targets, the observations, and the data reduction. In the first-year of data we detect Hα emission in 191 M {sub *} = 3 × 10{sup 9}-7 × 10{sup 11} M {sub ☉} galaxies at z = 0.7-1.1 and z = 1.9-2.7. In the current sample 83% of the resolved galaxies are rotation dominated, determined from a continuous velocity gradient and v {sub rot}/σ{sub 0} > 1, implying that the star-forming ''main sequence'' is primarily composed of rotating galaxies at both redshift regimes. When considering additional stricter criteria, the Hα kinematic maps indicate that at least ∼70% of the resolved galaxies are disk-like systems. Our high-quality KMOS data confirm the elevated velocity dispersions reported in previous integral field spectroscopy studies at z ≳ 0.7. For rotation-dominated disks, the average intrinsic velocity dispersion decreases by a factor of two from 50 km s{sup –1}at z ∼ 2.3 to 25 km s{sup –1}at z ∼ 0.9. Combined with existing results spanning z ∼ 0-3, we show that disk velocity dispersions follow an evolution that is consistent with the dependence of velocity dispersion on gas fractions predicted by marginally stable disk theory.

  10. The KMOS3D Survey: Design, First Results, and the Evolution of Galaxy Kinematics from 0.7 <= z <= 2.7

    NASA Astrophysics Data System (ADS)

    Wisnioski, E.; Förster Schreiber, N. M.; Wuyts, S.; Wuyts, E.; Bandara, K.; Wilman, D.; Genzel, R.; Bender, R.; Davies, R.; Fossati, M.; Lang, P.; Mendel, J. T.; Beifiori, A.; Brammer, G.; Chan, J.; Fabricius, M.; Fudamoto, Y.; Kulkarni, S.; Kurk, J.; Lutz, D.; Nelson, E. J.; Momcheva, I.; Rosario, D.; Saglia, R.; Seitz, S.; Tacconi, L. J.; van Dokkum, P. G.

    2015-02-01

    We present the KMOS3D survey, a new integral field survey of over 600 galaxies at 0.7 < z < 2.7 using KMOS at the Very Large Telescope. The KMOS3D survey utilizes synergies with multi-wavelength ground- and space-based surveys to trace the evolution of spatially resolved kinematics and star formation from a homogeneous sample over 5 Gyr of cosmic history. Targets, drawn from a mass-selected parent sample from the 3D-HST survey, cover the star formation-stellar mass (M *) and rest-frame (U - V) - M * planes uniformly. We describe the selection of targets, the observations, and the data reduction. In the first-year of data we detect Hα emission in 191 M * = 3 × 109-7 × 1011 M ⊙ galaxies at z = 0.7-1.1 and z = 1.9-2.7. In the current sample 83% of the resolved galaxies are rotation dominated, determined from a continuous velocity gradient and v rot/σ0 > 1, implying that the star-forming "main sequence" is primarily composed of rotating galaxies at both redshift regimes. When considering additional stricter criteria, the Hα kinematic maps indicate that at least ~70% of the resolved galaxies are disk-like systems. Our high-quality KMOS data confirm the elevated velocity dispersions reported in previous integral field spectroscopy studies at z >~ 0.7. For rotation-dominated disks, the average intrinsic velocity dispersion decreases by a factor of two from 50 km s-1at z ~ 2.3 to 25 km s-1at z ~ 0.9. Combined with existing results spanning z ~ 0-3, we show that disk velocity dispersions follow an evolution that is consistent with the dependence of velocity dispersion on gas fractions predicted by marginally stable disk theory. Based on observations obtained at the Very Large Telescope (VLT) of the European Southern Observatory (ESO), Paranal, Chile (ESO program IDS 092A-0091, 093.A-0079).

  11. From nearby to distant galaxies: kinematical and dynamical studies

    NASA Astrophysics Data System (ADS)

    Epinat, Benoit

    2009-09-01

    Kinematical studies of low and high redshift galaxies enables to probe galaxy formation and evolution scenarios. Integral field spectroscopy is a powerful tool to study with accuracy nearby galaxies kinematics. Recent observations also gives a new 2D vision of high redshift galaxies kinematics. This work mostly relies on the kinematical sample of galaxies GHASP. This control sample, composed of 203 local spiral and irregular galaxies in low density environments observed with Fabry-Perot techniques in the Ha line (6563 A), is by now the largest sample of Fabry-Perot data. After a revue on Fabry-Perot interferometry and a presentation of new data reduction procedures, my implications on both 3D-NTT Fabry-Perot instrument and the wide field spectrograph project (WFSpec) for galaxy evolution study with the european ELT are developed. The second section is dedicated to GHASP data. This sample have been fully reduced and analysed using new methods. The kinematical analysis of 2D kinematical maps has been undertaken with the study of the dark matter distribution, the rotation curves shape, bar signatures and the ionized gas velocity dispersion. In a third section, this local reference sample is used as a zero point for high redshift galaxies kinematical studies. The GHASP sample is projected at high redshift (z=1.7) in order to disentangle evolution effects from distance biases in high redshift galaxies kinematical data observed with SINFONI, OSIRIS and GIRAFFE. The kinematical analysis of new SINFONI high redshift observations is also presented and high redshift data found in the literature are compared with GHASP projected sample, suggesting some evolution of the galaxy dynamical support within the ages.

  12. A 3D optical study of Low Surface Brightness galaxies

    NASA Astrophysics Data System (ADS)

    Chemin, L.; Amram, P.; Carignan, C.; Balkowski, C.; van Driel, W.; Cayatte, V.; Hernandez, O.

    2004-12-01

    Integral field spectroscopy observations of the ionized gas in Low Surface Brightness Galaxies (LSBs) are presented. The goal of this study is to map their kinematics at high angular resolution and to study their dark matter (DM) distribution. For that purpose, we have used Fabry-Perot observations obtained at the CFH and ESO 3.6m telescopes. The new contribution of highly resolved velocity fields is crucial to study the role of non-circular motions on the dynamics of LSBs, and particularly on the shape of their DM halo profile (cusp- or core- dominated halo). Here are shown some examples of galaxies in which such motions exist in their central parts and prevent from determining the accurate shape of their DM halo.

  13. Surface topography study of prepared 3D printed moulds via 3D printer for silicone elastomer based nasal prosthesis

    NASA Astrophysics Data System (ADS)

    Abdullah, Abdul Manaf; Din, Tengku Noor Daimah Tengku; Mohamad, Dasmawati; Rahim, Tuan Noraihan Azila Tuan; Akil, Hazizan Md; Rajion, Zainul Ahmad

    2016-12-01

    Conventional prosthesis fabrication is highly depends on the hand creativity of laboratory technologist. The development in 3D printing technology offers a great help in fabricating affordable and fast yet esthetically acceptable prostheses. This study was conducted to discover the potential of 3D printed moulds for indirect silicone elastomer based nasal prosthesis fabrication. Moulds were designed using computer aided design (CAD) software (Solidworks, USA) and converted into the standard tessellation language (STL) file. Three moulds with layer thickness of 0.1, 0.2 and 0.3mm were printed utilizing polymer filament based 3D printer (Makerbot Replicator 2X, Makerbot, USA). Another one mould was printed utilizing liquid resin based 3D printer (Objet 30 Scholar, Stratasys, USA) as control. The printed moulds were then used to fabricate maxillofacial silicone specimens (n=10)/mould. Surface profilometer (Surfcom Flex, Accretech, Japan), digital microscope (KH77000, Hirox, USA) and scanning electron microscope (Quanta FEG 450, Fei, USA) were used to measure the surface roughness as well as the topological properties of fabricated silicone. Statistical analysis of One-Way ANOVA was employed to compare the surface roughness of the fabricated silicone elastomer. Result obtained demonstrated significant differences in surface roughness of the fabricated silicone (p<0.01). Further post hoc analysis also revealed significant differences in silicone fabricated using different 3D printed moulds (p<0.01). A 3D printed mould was successfully prepared and characterized. With surface topography that could be enhanced, inexpensive and rapid mould fabrication techniques, polymer filament based 3D printer is potential for indirect silicone elastomer based nasal prosthesis fabrication.

  14. 3D ultrasound computer tomography: update from a clinical study

    NASA Astrophysics Data System (ADS)

    Hopp, T.; Zapf, M.; Kretzek, E.; Henrich, J.; Tukalo, A.; Gemmeke, H.; Kaiser, C.; Knaudt, J.; Ruiter, N. V.

    2016-04-01

    Ultrasound Computer Tomography (USCT) is a promising new imaging method for breast cancer diagnosis. We developed a 3D USCT system and tested it in a pilot study with encouraging results: 3D USCT was able to depict two carcinomas, which were present in contrast enhanced MRI volumes serving as ground truth. To overcome severe differences in the breast shape, an image registration was applied. We analyzed the correlation between average sound speed in the breast and the breast density estimated from segmented MRIs and found a positive correlation with R=0.70. Based on the results of the pilot study we now carry out a successive clinical study with 200 patients. For this we integrated our reconstruction methods and image post-processing into a comprehensive workflow. It includes a dedicated DICOM viewer for interactive assessment of fused USCT images. A new preview mode now allows intuitive and faster patient positioning. We updated the USCT system to decrease the data acquisition time by approximately factor two and to increase the penetration depth of the breast into the USCT aperture by 1 cm. Furthermore the compute-intensive reflectivity reconstruction was considerably accelerated, now allowing a sub-millimeter volume reconstruction in approximately 16 minutes. The updates made it possible to successfully image first patients in our ongoing clinical study.

  15. In vitro quantification of the performance of model-based mono-planar and bi-planar fluoroscopy for 3D joint kinematics estimation.

    PubMed

    Tersi, Luca; Barré, Arnaud; Fantozzi, Silvia; Stagni, Rita

    2013-03-01

    Model-based mono-planar and bi-planar 3D fluoroscopy methods can quantify intact joints kinematics with performance/cost trade-off. The aim of this study was to compare the performances of mono- and bi-planar setups to a marker-based gold-standard, during dynamic phantom knee acquisitions. Absolute pose errors for in-plane parameters were lower than 0.6 mm or 0.6° for both mono- and bi-planar setups. Mono-planar setups resulted critical in quantifying the out-of-plane translation (error < 6.5 mm), and bi-planar in quantifying the rotation along bone longitudinal axis (error < 1.3°). These errors propagated to joint angles and translations differently depending on the alignment of the anatomical axes and the fluoroscopic reference frames. Internal-external rotation was the least accurate angle both with mono- (error < 4.4°) and bi-planar (error < 1.7°) setups, due to bone longitudinal symmetries. Results highlighted that accuracy for mono-planar in-plane pose parameters is comparable to bi-planar, but with halved computational costs, halved segmentation time and halved ionizing radiation dose. Bi-planar analysis better compensated for the out-of-plane uncertainty that is differently propagated to relative kinematics depending on the setup. To take its full benefits, the motion task to be investigated should be designed to maintain the joint inside the visible volume introducing constraints with respect to mono-planar analysis.

  16. Controlled architectural and chemotactic studies of 3D cell migration.

    PubMed

    Tayalia, Prakriti; Mazur, Eric; Mooney, David J

    2011-04-01

    Chemotaxis plays a critical role in tissue development and wound repair, and is widely studied using ex vivo model systems in applications such as immunotherapy. However, typical chemotactic models employ 2D systems that are less physiologically relevant or use end-point assays, that reveal little about the stepwise dynamics of the migration process. To overcome these limitations, we developed a new model system using microfabrication techniques, sustained drug delivery approaches, and theoretical modeling of chemotactic agent diffusion. This model system allows us to study the effects of 3D architecture and chemotactic agent gradient on immune cell migration in real time. We find that dendritic cell migration is characterized by a strong interplay between matrix architecture and chemotactic gradients, and migration is also influenced dramatically by the cell activation state. Our results indicate that Lipopolysaccharide-activated dendritic cells studied in a traditional transwell system actually exhibit anomalous migration behavior. Such a 3D ex vivo system lends itself for analyzing cell migratory behavior in response to single or multiple competitive cues and could prove useful in vaccine development.

  17. Nonlinear 3D MHD verification study: SpeCyl and PIXIE3D codes for RFP and Tokamak plasmas

    NASA Astrophysics Data System (ADS)

    Bonfiglio, D.; Cappello, S.; Chacon, L.

    2010-11-01

    A strong emphasis is presently placed in the fusion community on reaching predictive capability of computational models. An essential requirement of such endeavor is the process of assessing the mathematical correctness of computational tools, termed verification [1]. We present here a successful nonlinear cross-benchmark verification study between the 3D nonlinear MHD codes SpeCyl [2] and PIXIE3D [3]. Excellent quantitative agreement is obtained in both 2D and 3D nonlinear visco-resistive dynamics for reversed-field pinch (RFP) and tokamak configurations [4]. RFP dynamics, in particular, lends itself as an ideal non trivial test-bed for 3D nonlinear verification. Perspectives for future application of the fully-implicit parallel code PIXIE3D to RFP physics, in particular to address open issues on RFP helical self-organization, will be provided. [4pt] [1] M. Greenwald, Phys. Plasmas 17, 058101 (2010) [0pt] [2] S. Cappello and D. Biskamp, Nucl. Fusion 36, 571 (1996) [0pt] [3] L. Chac'on, Phys. Plasmas 15, 056103 (2008) [0pt] [4] D. Bonfiglio, L. Chac'on and S. Cappello, Phys. Plasmas 17 (2010)

  18. Evaluation of 3-D graphics software: A case study

    NASA Technical Reports Server (NTRS)

    Lores, M. E.; Chasen, S. H.; Garner, J. M.

    1984-01-01

    An efficient 3-D geometry graphics software package which is suitable for advanced design studies was developed. The advanced design system is called GRADE--Graphics for Advanced Design. Efficiency and ease of use are gained by sacrificing flexibility in surface representation. The immediate options were either to continue development of GRADE or to acquire a commercially available system which would replace or complement GRADE. Test cases which would reveal the ability of each system to satisfy the requirements were developed. A scoring method which adequately captured the relative capabilities of the three systems was presented. While more complex multi-attribute decision methods could be used, the selected method provides all the needed information without being so complex that it is difficult to understand. If the value factors are modestly perturbed, system Z is a clear winner based on its overall capabilities. System Z is superior in two vital areas: surfacing and ease of interface with application programs.

  19. Improved Surgery Planning Using 3-D Printing: a Case Study.

    PubMed

    Singhal, A J; Shetty, V; Bhagavan, K R; Ragothaman, Ananthan; Shetty, V; Koneru, Ganesh; Agarwala, M

    2016-04-01

    The role of 3-D printing is presented for improved patient-specific surgery planning. Key benefits are time saved and surgery outcome. Two hard-tissue surgery models were 3-D printed, for orthopedic, pelvic surgery, and craniofacial surgery. We discuss software data conversion in computed tomography (CT)/magnetic resonance (MR) medical image for 3-D printing. 3-D printed models save time in surgery planning and help visualize complex pre-operative anatomy. Time saved in surgery planning can be as much as two thirds. In addition to improved surgery accuracy, 3-D printing presents opportunity in materials research. Other hard-tissue and soft-tissue cases in maxillofacial, abdominal, thoracic, cardiac, orthodontics, and neurosurgery are considered. We recommend using 3-D printing as standard protocol for surgery planning and for teaching surgery practices. A quick turnaround time of a 3-D printed surgery model, in improved accuracy in surgery planning, is helpful for the surgery team. It is recommended that these costs be within 20 % of the total surgery budget.

  20. Development of a kinematic 3D carpal model to analyze in vivo soft-tissue interaction across multiple static postures.

    PubMed

    Marai, G; Crisco, Joseph J; Laidlaw, David H

    2009-01-01

    We developed a subject-specific kinematic model to analyze in vivo soft-tissue interaction in the carpus in static, unloaded postures. The bone geometry was extracted from a reference computed tomography volume image. The soft-tissue geometry, including cartilage and ligament tissues, was computationally modeled based on kinematic constraints; the constraints were extracted from multiple computed tomography scans corresponding to different carpal postures. The data collected in vivo was next coupled with numerical simulation in order to analyze the role of soft-tissues in different postures. The resulting model extends the state of biomechanical modeling by incorporating soft-tissue constraints across the carpus range of motion, while successfully using only physiological constraints. The model results suggest that soft-tissue wrapping constraints have substantial impact on carpus stability.

  1. Kinematic Analysis of Fold-Thrust-Belt Using Integrated Analogue Sandbox Modeling and 3D Palinspatic Reconstructions in Babar-Selaru Area, Banda Sea Region, Indonesia

    NASA Astrophysics Data System (ADS)

    Sapiie, Benyamin; Hadiana, Meli; Kurniawan, Ade; Daniel, Dicky; Danio, Harya; Fujimoto, Masamichi; Ohara, Michio; Alam Perdana, Lisnanda; Saputra, Afif

    2016-04-01

    Kinematic analysis of Babar-Selaru fold-thrust-belt is challenging and often difficult particularly in conducting seismic interpretation due to complex structural geometries. Resolving such as issue, in this study we proposed to use integrated seismic interpretation, analogue sandbox modeling and 3D palinspatic reconstructions. This paper is presented results of detail kinematic analysis for understanding tectonic evolution as well as mechanism of fold-thrust-belt in relation to their hydrocarbon prospect. Babar-Selaru Area is located within the collisional boundary between Australian continental margin and Banda Arc region of Indonesia. The area is characterized by complex deformation zone of fold-thrust-belt, involving Mesozoic and Tertiary sedimentary sequences of Australian continental margin. The age of deformation is ranging from 8-5 Ma. Seismic interpretations show two styles of faults developed in the area, which are thrust and normal faults system. The last deformation observed in the Babar Selaru area is controlled by south verging imbricated thin-skinned thrust fault system, with the staircase style of fault detachment. Although, both structural styles occurred in separated locations, they are formed not only in the same time but also related in time and space. Total extension is ranging from 1-3 % where average shortening is in the order of 35-38%. Sandbox modeling is an effective way to study and understand the style, pattern and geometry of the deformed sedimentary sequences in the study area. Based on comparison of five settings experiments (mainly different geological boundary condition) with more than 50 different modeling; deformation is particularly controlled by types and thickness of lithology package and detachment geometry. These two parameters were quite sensitive in generating different deformation style and pattern in Babar-Selaru fold-thrust-belt. Therefore, choosing the right combination of stratigraphy model and material setting are

  2. Elemental concentration distribution in human fingernails - A 3D study

    NASA Astrophysics Data System (ADS)

    Pineda-Vargas, C. A.; Mars, J. A.; Gihwala, D.

    2012-02-01

    The verification of pathologies has normally been based on analysis of blood (serum and plasma), and physiological tissue. Recently, nails and in particular human fingernails have become an important medium for pathological studies, especially those of environmental origin. The analytical technique of PIXE has been used extensively in the analysis of industrial samples and human tissue specimens. The application of the analytical technique to nails has been mainly to bulk samples. In this study we use micro-PIXE and -RBS, as both complementary and supplementary, to determine the elemental concentration distribution of human fingernails of individuals. We report on the 3D quantitative elemental concentration distributions (QECDs) of various elements that include C, N and O as major elements (10-20%), P, S, Cl, K and Ca as minor elements (1-10%) and Fe, Mn, Zn, Ti, Na, Mg, Cu, Ni, Cr, Rb, Br, Sr and Se as trace elements (less than 1%). For PIXE and RBS the specimens were bombarded with a 3 MeV proton beam. To ascertain any correlations in the quantitative elemental concentration distributions, a linear traverse analysis was performed across the width of the nail. Elemental distribution correlations were also obtained.

  3. Application of 3D printing technology in aerodynamic study

    NASA Astrophysics Data System (ADS)

    Olasek, K.; Wiklak, P.

    2014-08-01

    3D printing, as an additive process, offers much more than traditional machining techniques in terms of achievable complexity of a model shape. That fact was a motivation to adapt discussed technology as a method for creating objects purposed for aerodynamic testing. The following paper provides an overview of various 3D printing techniques. Four models of a standard NACA0018 aerofoil were manufactured in different materials and methods: MultiJet Modelling (MJM), Selective Laser Sintering (SLS) and Fused Deposition Modeling (FDM). Various parameters of the models have been included in the analysis: surface roughness, strength, details quality, surface imperfections and irregularities as well as thermal properties.

  4. In Vivo 3D Analysis of Thoracic Kinematics: Changes in Size and Shape During Breathing and Their Implications for Respiratory Function in Recent Humans and Fossil Hominins.

    PubMed

    Bastir, Markus; García-Martínez, Daniel; Torres-Tamayo, Nicole; Sanchis-Gimeno, Juan Alberto; O'Higgins, Paul; Utrilla, Cristina; Torres Sánchez, Isabel; García Río, Francisco

    2017-02-01

    The human ribcage expands and contracts during respiration as a result of the interaction between the morphology of the ribs, the costo-vertebral articulations and respiratory muscles. Variations in these factors are said to produce differences in the kinematics of the upper thorax and the lower thorax, but the extent and nature of any such differences and their functional implications have not yet been quantified. Applying geometric morphometrics we measured 402 three-dimensional (3D) landmarks and semilandmarks of 3D models built from computed tomographic scans of thoraces of 20 healthy adult subjects in maximal forced inspiration (FI) and expiration (FE). We addressed the hypothesis that upper and lower parts of the ribcage differ in kinematics and compared different models of functional compartmentalization. During inspiration the thorax superior to the level of the sixth ribs undergoes antero-posterior expansion that differs significantly from the medio-lateral expansion characteristic of the thorax below this level. This supports previous suggestions for dividing the thorax into a pulmonary and diaphragmatic part. While both compartments differed significantly in mean size and shape during FE and FI the size changes in the lower compartment were significantly larger. Additionally, for the same degree of kinematic shape change, the pulmonary thorax changes less in size than the diaphragmatic thorax. Therefore, variations in the form and function of the diaphragmatic thorax will have a strong impact on respiratory function. This has important implications for interpreting differences in thorax shape in terms of respiratory functional differences within and among recent humans and fossil hominins. Anat Rec, 300:255-264, 2017. © 2016 Wiley Periodicals, Inc.

  5. Assessment of 3D Models Used in Contours Studies

    ERIC Educational Resources Information Center

    Alvarez, F. J. Ayala; Parra, E. B. Blazquez; Tubio, F. Montes

    2015-01-01

    This paper presents an experimental research focusing on the view of first year students. The aim is to check the quality of implementing 3D models integrated in the curriculum. We search to determine students' preference between the various means facilitated in order to understand the given subject. Students have been respondents to prove the…

  6. A 3D measurement of the offset in paleoseismological studies

    NASA Astrophysics Data System (ADS)

    Ferrater, Marta; Echeverria, Anna; Masana, Eulàlia; Martínez-Díaz, José J.; Sharp, Warren D.

    2016-05-01

    The slip rate of a seismogenic fault is a crucial parameter for establishing the contribution of the fault to the seismic hazard. It is calculated from measurements of the offset of linear landforms, such channels, produced by the fault combined with their age. The three-dimensional measurement of offset in buried paleochannels is subject to uncertainties that need to be quantitatively assessed and propagated into the slip rate. Here, we present a set of adapted scripts to calculate the net, lateral and vertical tectonic offset components caused by faults, together with their associated uncertainties. This technique is applied here to a buried channel identified in the stratigraphic record during a paleoseismological study at the El Saltador site (Alhama de Murcia fault, Iberian Peninsula). After defining and measuring the coordinates of the key points of a buried channel in the walls of eight trenches excavated parallel to the fault, we (a) adjusted a 3D straight line to these points and then extrapolated the tendency of this line onto a simplified fault plane; (b) repeated these two steps for the segment of the channel in the other side of the fault; and (c) measured the distance between the two resulting intersection points with the fault plane. In doing so, we avoided the near fault modification of the channel trace and obtained a three-dimensional measurement of offset and its uncertainty. This methodology is a substantial modification of previous procedures that require excavating progressively towards the fault, leading to possible underestimation of offset due to diffuse deformation near the fault. Combining the offset with numerical dating of the buried channel via U-series on soil carbonate, we calculated a maximum estimate of the net slip rate and its vertical and lateral components for the Alhama de Murcia fault.

  7. Study, simulation and design of a 3D clinostat

    NASA Astrophysics Data System (ADS)

    Pavone, Valentina; Guarnieri, Vincenzo; Lobascio, Cesare; Soma, Aurelio; Bosso, Nicola; Lamantea, Matteo Maria

    High cost and limited number of physically executable experiments in space have introduced the need for ground simulation systems that enable preparing experiments to be carried out on board, identifying phenomena associated with the altered gravity conditions, and taking advantage of these conditions, as in Biotechnology. Among systems developed to simulate microgravity, especially for life sciences experiments, different types of clinostats were realized. This work deals with mechanical design of a three-dimensional clinostat and simulation of the dynamic behavior of the system by varying the operating parameters. The design and simulation phase was preceded by a careful analysis of the state of art and by the review of the most recent results, in particular from the major investigators of Life Sciences in Space. The mechanical design is quite innovative by adoption of a structure entirely in aluminum, which allows robustness while reducing the overall weight. The transmission system of motion has been optimized by means of brushless DC micro motors, light and compact, which helped to reduce weight, dimensions, power consumption and increase the reliability and durability of the system. The study of the dynamic behavior using SIMPACK, a multibody simulation software, led to results in line with those found in the most important and recent scientific publications. This model was also appropriately configured to represent any desired operating condition, and for eventual system scalability. It would be interesting to generate simulated hypogravity - e.g.: 0.38-g (Mars) or 0.17-g (Moon). This would allow to investigate how terrestrial life forms can grow in other planetary habitats, or to determine the gravity threshold response of different organisms. At the moment, such a system can only be achieved by centrifuges in real microgravity. We are confident that simulation and associated tests with our 3D clinostat can help adjusting the parameters allowing variable g

  8. OB3D, a new set of 3D objects available for research: a web-based study

    PubMed Central

    Buffat, Stéphane; Chastres, Véronique; Bichot, Alain; Rider, Delphine; Benmussa, Frédéric; Lorenceau, Jean

    2014-01-01

    Studying object recognition is central to fundamental and clinical research on cognitive functions but suffers from the limitations of the available sets that cannot always be modified and adapted to meet the specific goals of each study. We here present a new set of 3D scans of real objects available on-line as ASCII files, OB3D. These files are lists of dots, each defined by a triplet of spatial coordinates and their normal that allow simple and highly versatile transformations and adaptations. We performed a web-based experiment to evaluate the minimal number of dots required for the denomination and categorization of these objects, thus providing a reference threshold. We further analyze several other variables derived from this data set, such as the correlations with object complexity. This new stimulus set, which was found to activate the Lower Occipital Complex (LOC) in another study, may be of interest for studies of cognitive functions in healthy participants and patients with cognitive impairments, including visual perception, language, memory, etc. PMID:25339920

  9. On 3D Dimension: Study cases for Archaeological sites

    NASA Astrophysics Data System (ADS)

    D'Urso, M. G.; Marino, C. L.; Rotondi, A.

    2014-04-01

    For more than a century the tridimensional vision has been of interest for scientists and users in several fields of application. The mathematical bases have remained substantially unchanged but only the new technologies have allowed us to make the vision really impressive. Photography opens new frontiers and has enriched of physical, mathematical, chemical, informatical and topographic notions by making the images so real to make the observer fully immersed into the represented scene. By means of active googless the 3D digital technique, commonly used for video games, makes possible animations without limitations in the dimension of the images thanks to the improved performances of the graphic processor units and related hardware components. In this paper we illustrate an experience made by the students of the MSc'degree course of Topography, active at the University of Cassino and Southern Lazio, in which the photography has been applied as an innovative technique for the surveying of cultural heritage. The tests foresee the use of traditional techniques of survey with 3D digital images and use of GPS sensors. The ultimate objective of our experience is the insertion in the web, allowing us the visualization of the 3D images equipped with all data. In conclusion these new methods of survey allow for the fusion of extremely different techniques, in such an impressive way to make them inseparable and justifying the origin of the neologism "Geomatics" coined at the Laval University (Canada) during the eighties.

  10. 3D tomodosimetry using long scintillating fibers: A feasibility study

    SciTech Connect

    Goulet, Mathieu; Archambault, Louis; Beaulieu, Luc; Gingras, Luc

    2013-10-15

    Purpose: 3D dosimetry is recognized as an ideal for patient-specific quality assurance (QA) of highly conformal radiotherapy treatments. However, existing 3D dosimeters are not straightforward to implement in the clinic, as their read-out procedure is often tedious and their accuracy, precision, and/or sample size exhibit limitations. The purpose of this work is to develop a 3D dosimeter based on the concept of tomodosimetry inside concentric cylindrical planes using long scintillating fibers for the QA of modern radiotherapy techniques such as intensity-modulated radiation therapy (IMRT) or intensity-modulated arc therapy (IMAT).Methods: Using a model-based simulation, scintillating fibers were modeled on three concentric cylindrical planes of radii 2.5, 5.0, and 7.5 cm, inside a 10 cm radius water-equivalent cylinder phantom. The phantom was set to rotate around its central axis, made parallel to the linac gantry axis of rotation. Light acquisitions were simulated using the calculated dose from the treatment planning software and reconstructed in each cylindrical plane at a resolution of 1 mm{sup 2} using a total-variation minimization iterative reconstruction algorithm. The 3D dose was then interpolated from the reconstructed cylindrical plane doses at a resolution of 1 mm{sup 3}. Different scintillating fiber patterns were compared by varying the angle of each fiber in its cylindrical plane and introducing a light-tight cut in each fiber. The precision of the reconstructed cylindrical dose distribution was evaluated using a Poisson modeling of the acquired light signals and the accuracy of the interpolated 3D dose was evaluated using an IMRT clinical plan for a prostate case.Results: Straight scintillating fiber patterns with light-tight cuts were the most accurate in cylindrical dose reconstruction, showing less than 0.5 mm distance-to-agreement in dose gradients and a mean local dose difference of less than 0.2% in the high dose region for a 10 × 10 cm{sup 2

  11. Clinical Study of 3D Imaging and 3D Printing Technique for Patient-Specific Instrumentation in Total Knee Arthroplasty.

    PubMed

    Qiu, Bing; Liu, Fei; Tang, Bensen; Deng, Biyong; Liu, Fang; Zhu, Weimin; Zhen, Dong; Xue, Mingyuan; Zhang, Mingjiao

    2017-01-25

    Patient-specific instrumentation (PSI) was designed to improve the accuracy of preoperative planning and postoperative prosthesis positioning in total knee arthroplasty (TKA). However, better understanding needs to be achieved due to the subtle nature of the PSI systems. In this study, 3D printing technique based on the image data of computed tomography (CT) has been utilized for optimal controlling of the surgical parameters. Two groups of TKA cases have been randomly selected as PSI group and control group with no significant difference of age and sex (p > 0.05). The PSI group is treated with 3D printed cutting guides whereas the control group is treated with conventional instrumentation (CI). By evaluating the proximal osteotomy amount, distal osteotomy amount, valgus angle, external rotation angle, and tibial posterior slope angle of patients, it can be found that the preoperative quantitative assessment and intraoperative changes can be controlled with PSI whereas CI is relied on experience. In terms of postoperative parameters, such as hip-knee-ankle (HKA), frontal femoral component (FFC), frontal tibial component (FTC), and lateral tibial component (LTC) angles, there is a significant improvement in achieving the desired implant position (p < 0.05). Assigned from the morphology of patients' knees, the PSI represents the convergence of congruent designs with current personalized treatment tools. The PSI can achieve less extremity alignment and greater accuracy of prosthesis implantation compared against control method, which indicates potential for optimal HKA, FFC, and FTC angles.

  12. MESA: A 3-D Eulerian hydrocode for penetration mechanics studies

    SciTech Connect

    Mandell, D.A.; Holian, K.S.; Henninger, R.

    1991-01-01

    We describe an explicit, finite-difference hydrocode, called MESA, and compare calculations to metal and ceramic plate impacts with spall and to Taylor cylinder tests. The MESA code was developed with support from DARPA, the Army and the Marine Corps for use in armor/anti-armor problems primarily, but the code has been used for a number of other applications. MESA includes 2-D and 3-D Eulerian hydrodynamics, a number of material strength and fracture models, and a programmed burn high explosives model. 15 refs., 4 figs.

  13. Performing accurate joint kinematics from 3-D in vivo image sequences through consensus-driven simultaneous registration.

    PubMed

    Jacq, Jean-José; Cresson, Thierry; Burdin, Valérie; Roux, Christian

    2008-05-01

    This paper addresses the problem of the robust registration of multiple observations of the same object. Such a problem typically arises whenever it becomes necessary to recover the trajectory of an evolving object observed through standard 3-D medical imaging techniques. The instances of the tracked object are assumed to be variously truncated, locally subject to morphological evolutions throughout the sequence, and imprinted with significant segmentation errors as well as significant noise perturbations. The algorithm operates through the robust and simultaneous registration of all surface instances of a given object through median consensus. This operation consists of two interwoven processes set up to work in close collaboration. The first one progressively generates a median and implicit shape computed with respect to current estimations of the registration transformations, while the other refines these transformations with respect to the current estimation of their median shape. When compared with standard robust techniques, tests reveal significant improvements, both in robustness and precision. The algorithm is based on widely-used techniques, and proves highly effective while offering great flexibility of utilization.

  14. Study on 3D CFBG vibration sensor and its application

    NASA Astrophysics Data System (ADS)

    Nan, Qiuming; Li, Sheng

    2016-03-01

    A novel variety of three dimensional (3D) vibration sensor based on chirped fiber Bragg grating (CFBG) is developed to measure 3D vibration in the mechanical equipment field. The sensor is composed of three independent vibration sensing units. Each unit uses double matched chirped gratings as sensing elements, and the sensing signal is processed by the edge filtering demodulation method. The structure and principle of the sensor are theoretically analyzed, and its performances are obtained from some experiments and the results are as follows: operating frequency range of the sensor is 10 Hz‒500 Hz; acceleration measurement range is 2 m·s-2‒30 m·s-2; sensitivity is about 70 mV/m·s-2; crosstalk coefficient is greater than 22 dB; self-compensation for temperature is available. Eventually the sensor is applied to monitor the vibration state of radiation pump. Seen from its experiments and applications, the sensor has good sensing performances, which can meet a certain requirement for some engineering measurement.

  15. Markerless 3D motion capture for animal locomotion studies

    PubMed Central

    Sellers, William Irvin; Hirasaki, Eishi

    2014-01-01

    ABSTRACT Obtaining quantitative data describing the movements of animals is an essential step in understanding their locomotor biology. Outside the laboratory, measuring animal locomotion often relies on video-based approaches and analysis is hampered because of difficulties in calibration and often the limited availability of possible camera positions. It is also usually restricted to two dimensions, which is often an undesirable over-simplification given the essentially three-dimensional nature of many locomotor performances. In this paper we demonstrate a fully three-dimensional approach based on 3D photogrammetric reconstruction using multiple, synchronised video cameras. This approach allows full calibration based on the separation of the individual cameras and will work fully automatically with completely unmarked and undisturbed animals. As such it has the potential to revolutionise work carried out on free-ranging animals in sanctuaries and zoological gardens where ad hoc approaches are essential and access within enclosures often severely restricted. The paper demonstrates the effectiveness of video-based 3D photogrammetry with examples from primates and birds, as well as discussing the current limitations of this technique and illustrating the accuracies that can be obtained. All the software required is open source so this can be a very cost effective approach and provides a methodology of obtaining data in situations where other approaches would be completely ineffective. PMID:24972869

  16. A Mechanistic Study of Wetting Superhydrophobic Porous 3D Meshes.

    PubMed

    Yohe, Stefan T; Freedman, Jonathan D; Falde, Eric J; Colson, Yolonda L; Grinstaff, Mark W

    2013-08-07

    Superhydrophobic, porous, 3D materials composed of poly( ε -caprolactone) (PCL) and the hydrophobic polymer dopant poly(glycerol monostearate- co- ε -caprolactone) (PGC-C18) are fabricated using the electrospinning technique. These 3D materials are distinct from 2D superhydrophobic surfaces, with maintenance of air at the surface as well as within the bulk of the material. These superhydrophobic materials float in water, and when held underwater and pressed, an air bubble is released and will rise to the surface. By changing the PGC-C18 doping concentration in the meshes and/or the fiber size from the micro- to nanoscale, the long-term stability of the entrapped air layer is controlled. The rate of water infiltration into the meshes, and the resulting displacement of the entrapped air, is quantitatively measured using X-ray computed tomography. The properties of the meshes are further probed using surfactants and solvents of different surface tensions. Finally, the application of hydraulic pressure is used to quantify the breakthrough pressure to wet the meshes. The tools for fabrication and analysis of these superhydrophobic materials as well as the ability to control the robustness of the entrapped air layer are highly desirable for a number of existing and emerging applications.

  17. Organizational Learning Goes Virtual?: A Study of Employees' Learning Achievement in Stereoscopic 3D Virtual Reality

    ERIC Educational Resources Information Center

    Lau, Kung Wong

    2015-01-01

    Purpose: This study aims to deepen understanding of the use of stereoscopic 3D technology (stereo3D) in facilitating organizational learning. The emergence of advanced virtual technologies, in particular to the stereo3D virtual reality, has fundamentally changed the ways in which organizations train their employees. However, in academic or…

  18. Comparison of 3D-OP-OSEM and 3D-FBP reconstruction algorithms for High-Resolution Research Tomograph studies: effects of randoms estimation methods

    NASA Astrophysics Data System (ADS)

    van Velden, Floris H. P.; Kloet, Reina W.; van Berckel, Bart N. M.; Wolfensberger, Saskia P. A.; Lammertsma, Adriaan A.; Boellaard, Ronald

    2008-06-01

    The High-Resolution Research Tomograph (HRRT) is a dedicated human brain positron emission tomography (PET) scanner. Recently, a 3D filtered backprojection (3D-FBP) reconstruction method has been implemented to reduce bias in short duration frames, currently observed in 3D ordinary Poisson OSEM (3D-OP-OSEM) reconstructions. Further improvements might be expected using a new method of variance reduction on randoms (VRR) based on coincidence histograms instead of using the delayed window technique (DW) to estimate randoms. The goal of this study was to evaluate VRR in combination with 3D-OP-OSEM and 3D-FBP reconstruction techniques. To this end, several phantom studies and a human brain study were performed. For most phantom studies, 3D-OP-OSEM showed higher accuracy of observed activity concentrations with VRR than with DW. However, both positive and negative deviations in reconstructed activity concentrations and large biases of grey to white matter contrast ratio (up to 88%) were still observed as a function of scan statistics. Moreover 3D-OP-OSEM+VRR also showed bias up to 64% in clinical data, i.e. in some pharmacokinetic parameters as compared with those obtained with 3D-FBP+VRR. In the case of 3D-FBP, VRR showed similar results as DW for both phantom and clinical data, except that VRR showed a better standard deviation of 6-10%. Therefore, VRR should be used to correct for randoms in HRRT PET studies.

  19. A comparative study between a rectilinear 3-D seismic survey and a concentric-circle 3-D seismic survey

    SciTech Connect

    Maldonado, B.; Hussein, H.S.

    1994-12-31

    Due to the rectilinear nature of the previous 3D seismic survey, the details necessary for proper interpretation were absent. Theoretically, concentric 3D seismic technology may provide an avenue for gaining more and higher quality data coverage. Problems associated with recording a rectilinear 3D seismic grid over the salt dome in this area have created the need to investigate the use of such procedures as the concentric-circle 3D seismic acquisition technique. The difficulty of imaging salt dome flanks with conventional rectilinear 3D seismic may be a result of the inability to precisely predict the lateral velocity-field variation adjacent to both salt and sediments. The dramatic difference in the interval velocities of salt and sediments causes the returning ray to severely deviate from being a hyperbolic path. This hampers the ability to predict imaging points near the salt/sediment interface. Perhaps the most difficult areas to image with rectilinear seismic surveys are underneath salt overhangs. Modeling suggests that a significant increase in the number of rays captured from beneath a salt overhang can be achieved with the concentric-circle method. This paper demonstrates the use of the ``circle shoot`` on a survey conducted over a salt dome in the Gulf of Mexico. A total of 80 concentric circles cover an area which is equivalent to 31,000 acres. The final post-stack data were sorted into bins with dimensions of 25 meters by 25 meters. A comparison of 3D rectilinear shooting vs. 3D concentric circle shooting over the same area will show an improvement in data quality and signal-to-noise characteristics.

  20. Computational study of 3-D Benard convection with gravitational modulation

    NASA Technical Reports Server (NTRS)

    Biringen, S.; Peltier, L. J.

    1989-01-01

    In this numerical study the effects of a modulated gravitational field on three-dimensional Rayleigh-Benard convection with heating from above or from below is investigated. The full, nonlinear, time-dependent, Boussinesq Navier-Stokes equations and the energy equation are solved by a semiimplicit, pseudo-spectral procedure. This study has been motivated by the need to better understand the effects of vibration (G-Jitter) on fluids systems especially in the low gravity environment.

  1. Towards a collaborative and interoperable 3D Building database - A case study in Walloon region

    NASA Astrophysics Data System (ADS)

    Hajji, R.; Billen, R.

    2012-10-01

    The definition of a 3D Reference model is the prerequisite for increasing data interoperability and facing regional, national and international challenges around geographic information. Such action requires investigation of 3D user requirements and a collaborative framework to reach a consensus on common 3D data specifications. The paper presents premise reflexions about relevant issues to shape efforts towards a methodological and generic approach for dealing with a collaborative 3D reference model as a fundamental building block of 3D GIS collaborative solution. As a pilot project, we demonstrate, through a case study of the Liege city in Belgium, how data collected from different providers in Walloon region can be reengineered and then integrated in a 3D collaborative interoperable database compatible with CityGML.

  2. DIY 3D printing of custom orthopaedic implants: a proof of concept study.

    PubMed

    Frame, Mark; Leach, William

    2014-03-01

    3D printing is an emerging technology that is primarily used for aiding the design and prototyping of implants. As this technology has evolved it has now become possible to produce functional and definitive implants manufactured using a 3D printing process. This process, however, previously required a large financial investment in complex machinery and professionals skilled in 3D product design. Our pilot study's aim was to design and create a 3D printed custom orthopaedic implant using only freely available consumer hardware and software.

  3. 3D MHD Study of Helias and Heliotron

    DTIC Science & Technology

    1992-09-01

    Loss and Radial Electric Field in Wendelstein VII-A Stellarator ; Oct. 1991 N IFS-i 18 Y. Kondoh and Y. Hosaka, Kernel Optimum Nearly-analytical...30 September -- 7 October 1992 IAEA-CN-56/D-1 -4 31) MIlD Study or Ielias and lIfliotron 1’. Hayashi. T. Sato, W. Lotz. P. Merkel, J. Nuifirenbyerg...AGENCY Ŕ •JI" " FOURTEENTH INTERNATIONAL CONFERENCE ON PLASMA Zo PHYSICS AND CONTROLLED NUCLEAR FUSION RESEARCH Wirzburg, Germany, 30 September - 7

  4. Scalable nanohelices for predictive studies and enhanced 3D visualization.

    PubMed

    Meagher, Kwyn A; Doblack, Benjamin N; Ramirez, Mercedes; Davila, Lilian P

    2014-11-12

    Spring-like materials are ubiquitous in nature and of interest in nanotechnology for energy harvesting, hydrogen storage, and biological sensing applications. For predictive simulations, it has become increasingly important to be able to model the structure of nanohelices accurately. To study the effect of local structure on the properties of these complex geometries one must develop realistic models. To date, software packages are rather limited in creating atomistic helical models. This work focuses on producing atomistic models of silica glass (SiO₂) nanoribbons and nanosprings for molecular dynamics (MD) simulations. Using an MD model of "bulk" silica glass, two computational procedures to precisely create the shape of nanoribbons and nanosprings are presented. The first method employs the AWK programming language and open-source software to effectively carve various shapes of silica nanoribbons from the initial bulk model, using desired dimensions and parametric equations to define a helix. With this method, accurate atomistic silica nanoribbons can be generated for a range of pitch values and dimensions. The second method involves a more robust code which allows flexibility in modeling nanohelical structures. This approach utilizes a C++ code particularly written to implement pre-screening methods as well as the mathematical equations for a helix, resulting in greater precision and efficiency when creating nanospring models. Using these codes, well-defined and scalable nanoribbons and nanosprings suited for atomistic simulations can be effectively created. An added value in both open-source codes is that they can be adapted to reproduce different helical structures, independent of material. In addition, a MATLAB graphical user interface (GUI) is used to enhance learning through visualization and interaction for a general user with the atomistic helical structures. One application of these methods is the recent study of nanohelices via MD simulations for

  5. Scalable Nanohelices for Predictive Studies and Enhanced 3D Visualization

    PubMed Central

    Meagher, Kwyn A.; Doblack, Benjamin N.; Ramirez, Mercedes; Davila, Lilian P.

    2014-01-01

    Spring-like materials are ubiquitous in nature and of interest in nanotechnology for energy harvesting, hydrogen storage, and biological sensing applications.  For predictive simulations, it has become increasingly important to be able to model the structure of nanohelices accurately.  To study the effect of local structure on the properties of these complex geometries one must develop realistic models.  To date, software packages are rather limited in creating atomistic helical models.  This work focuses on producing atomistic models of silica glass (SiO2) nanoribbons and nanosprings for molecular dynamics (MD) simulations. Using an MD model of “bulk” silica glass, two computational procedures to precisely create the shape of nanoribbons and nanosprings are presented.  The first method employs the AWK programming language and open-source software to effectively carve various shapes of silica nanoribbons from the initial bulk model, using desired dimensions and parametric equations to define a helix.  With this method, accurate atomistic silica nanoribbons can be generated for a range of pitch values and dimensions.  The second method involves a more robust code which allows flexibility in modeling nanohelical structures.  This approach utilizes a C++ code particularly written to implement pre-screening methods as well as the mathematical equations for a helix, resulting in greater precision and efficiency when creating nanospring models.  Using these codes, well-defined and scalable nanoribbons and nanosprings suited for atomistic simulations can be effectively created.  An added value in both open-source codes is that they can be adapted to reproduce different helical structures, independent of material.  In addition, a MATLAB graphical user interface (GUI) is used to enhance learning through visualization and interaction for a general user with the atomistic helical structures.  One application of these methods is the recent study of nanohelices

  6. High pressure system for 3-D study of elastic anisotropy

    NASA Astrophysics Data System (ADS)

    Lokajicek, T.; Pros, Z.; Klima, K.

    2003-04-01

    New high pressure system was designed for the study of elastic anisotropy of condensed matter under high confining pressure up to 700 MPa. Simultaneously could be measured dynamic and static parameters: a) dynamic parameters by ultrasonic sounding, b) static parameters by measuring of spherical sample deformation. The measurement is carried out on spherical samples diameter 50 +/- 0.01 mm. Higher value of confining pressure was reached due to the new construction of sample positioning unit. The positioning unit is equipped with two Portecap step motors, which are located inside the vessel and make possible to rotate with the sphere and couple of piezoceramic transducers. Sample deformation is measured in the same direction as ultrasonic signal travel time. Only electric leads connects inner part of high pressure vessel with surrounding environment. Experimental set up enables: - simultaneous P-wave ultrasonic sounding, - measurement of current sample deformation at sounding points, - measurement of current value of confining pressure and - measurement of current stress media temperature. Air driven high pressure pump Haskel is used to produce high value of confining pressure up to 700 MPa. Ultrasonic signals are recorded by digital scope Agilent 54562 with sampling frequency 100 MHz. Control and measuring software was developed under Agilent VEE software environment working under MS Win 2000 operating system. Measuring set up was tested by measurement of monomineral spherical samples of quartz and corundum. Both of them have trigonal symmetry. The measurement showed that the P-wave velocity range of quartz was between 5.7-7.0 km/sec. and velocity range of corundum was between 9.7-10.9 km/sec. High pressure resistant LVDT transducers Mesing together with Intronix electronic unit were used to monitor sample deformation. Sample deformation is monitored with the accuracy of 0.1 micron. All test measurements proved the good accuracy of the whole measuring set up. This

  7. Developing and Testing a 3d Cadastral Data Model a Case Study in Australia

    NASA Astrophysics Data System (ADS)

    Aien, A.; Kalantari, M.; Rajabifard, A.; Williamson, I. P.; Shojaei, D.

    2012-07-01

    and physical extent of 3D properties and associated interests. The data model extends the traditional cadastral requirements to cover other applications such as urban planning and land valuation and taxation. A demonstration of a test system on the proposed data model is also presented. The test is based on a case study in Victoria, Australia to evaluate the effectiveness of the data model.

  8. Experimental Studies on the 3D Macro- and Microphysics of Magnetic Reconnection

    NASA Astrophysics Data System (ADS)

    Jara-Almonte, J.; Ji, H.; Yamada, M.; Yoo, J.; Fox, W. R., II

    2015-12-01

    Magnetic reconnection has been extensively studied in 2D geometries for many decades and considerable progress has been made in understating 2D reconnection physics, yet in real plasmas reconnection is fundamentally 3D in nature. Only recently has it become possible to study 3D reconnection using simulations, however some initial results have suggested that the inclusion of 3D effects does not strongly affect the basic properties of reconnection (e.g. reconnection rate or particle acceleration). Yet on the other hand, previous experiments, without direct 3D measurements, have implied that 3D effects could be important even in a quasi-2D system. Here we experimentally study both the (1) macro- and (2) microphysics of 3D reconnection in order to directly test the importance of 3D effects in a quasi-2D experiment. Using fully simultaneous 3D measurements, it is shown that during highly driven reconnection the macroscopic structure of the current sheet can become strongly 3D despite an essentially 2D upstream region. The correlation length along the current sheet is measured to be far shorter than suggested by kinetic simulations. Results from new experiments with stronger reconnection drive and diagnostics designed to estimate the 3D reconnection rate will be discussed. With regards to (2), the 3D microphysics, new diagnostics capable of measuring fluctuations at frequencies up to the electron cyclotron frequency (~ 300 MHz) have been developed and have identified the presence of very high frequency waves (~ 100 MHz) during asymmetric reconnection, localized to the low-density side. The detailed properties of these waves, including the measured power spectra and dispersion relation, will be discussed and compared with both previous satellite observations of high-frequency waves as well as with theoretical predictions on the generation of whistler waves during reconnection.

  9. Understanding Human Perception of Building Categories in Virtual 3d Cities - a User Study

    NASA Astrophysics Data System (ADS)

    Tutzauer, P.; Becker, S.; Niese, T.; Deussen, O.; Fritsch, D.

    2016-06-01

    Virtual 3D cities are becoming increasingly important as a means of visually communicating diverse urban-related information. To get a deeper understanding of a human's cognitive experience of virtual 3D cities, this paper presents a user study on the human ability to perceive building categories (e.g. residential home, office building, building with shops etc.) from geometric 3D building representations. The study reveals various dependencies between geometric properties of the 3D representations and the perceptibility of the building categories. Knowledge about which geometries are relevant, helpful or obstructive for perceiving a specific building category is derived. The importance and usability of such knowledge is demonstrated based on a perception-guided 3D building abstraction process.

  10. Possibility of reconstruction of dental plaster cast from 3D digital study models

    PubMed Central

    2013-01-01

    Objectives To compare traditional plaster casts, digital models and 3D printed copies of dental plaster casts based on various criteria. To determine whether 3D printed copies obtained using open source system RepRap can replace traditional plaster casts in dental practice. To compare and contrast the qualities of two possible 3D printing options – open source system RepRap and commercially available 3D printing. Design and settings A method comparison study on 10 dental plaster casts from the Orthodontic department, Department of Stomatology, 2nd medical Faulty, Charles University Prague, Czech Republic. Material and methods Each of 10 plaster casts were scanned by inEos Blue scanner and the printed on 3D printer RepRap [10 models] and ProJet HD3000 3D printer [1 model]. Linear measurements between selected points on the dental arches of upper and lower jaws on plaster casts and its 3D copy were recorded and statistically analyzed. Results 3D printed copies have many advantages over traditional plaster casts. The precision and accuracy of the RepRap 3D printed copies of plaster casts were confirmed based on the statistical analysis. Although the commercially available 3D printing enables to print more details than the RepRap system, it is expensive and for the purpose of clinical use can be replaced by the cheaper prints obtained from RepRap printed copies. Conclusions Scanning of the traditional plaster casts to obtain a digital model offers a pragmatic approach. The scans can subsequently be used as a template to print the plaster casts as required. Using 3D printers can replace traditional plaster casts primarily due to their accuracy and price. PMID:23721330

  11. Improving Assistive Technology Service by Using 3D Printing: Three Case Studies.

    PubMed

    Watanabe, Takashi; Hatakeyama, Takuro; Tomiita, Mitsuru

    2015-01-01

    Assistive technology services are essential for adapting assistive devices to the individual needs of users with disabilities. In this study, we attempted to apply three-dimensional (3D) printing technology to three actual cases, and to study its use, effectiveness, and future applications. We assessed the usefulness of 3D printing technology by categorizing its utilization after reviewing the outcomes of these case studies. In future work, we aim to gather additional case studies and derive information on using 3D printing technology that will enable its effective application in the process of assistive technology services.

  12. Genre Matters: A Comparative Study on the Entertainment Effects of 3D in Cinematic Contexts

    NASA Astrophysics Data System (ADS)

    Ji, Qihao; Lee, Young Sun

    2014-09-01

    Built upon prior comparative studies of 3D and 2D films, the current project investigates the effects of 2D and 3D on viewers' perception of enjoyment, narrative engagement, presence, involvement, and flow across three movie genres (Action/fantasy vs. Drama vs. Documentary). Through a 2 by 3 mixed factorial design, participants (n = 102) were separated into two viewing conditions (2D and 3D) and watched three 15-min film segments. Result suggested both visual production methods are equally efficient in terms of eliciting people's enjoyment, narrative engagement, involvement, flow and presence, no effects of visual production method was found. In addition, through examining the genre effects in both 3D and 2D conditions, we found that 3D works better for action movies than documentaries in terms of eliciting viewers' perception of enjoyment and presence, similarly, it improves views' narrative engagement for documentaries than dramas substantially. Implications and limitations are discussed in detail.

  13. Gait strategy in patients with Ehlers-Danlos syndrome hypermobility type: a kinematic and kinetic evaluation using 3D gait analysis.

    PubMed

    Galli, Manuela; Cimolin, Veronica; Rigoldi, Chiara; Castori, Marco; Celletti, Claudia; Albertini, Giorgio; Camerota, Filippo

    2011-01-01

    The aim of this study was to quantify the gait patterns of adults with joint hypermobility syndrome/Ehlers-Danlos syndrome (JHS/EDS-HT) hypermobility type, using Gait Analysis. We quantified the gait strategy in 12 JHS/EDS-HT adults individuals (age: 43.08+6.78 years) compared to 20 healthy controls (age: 37.23±8.91 years), in terms of kinematics and kinetics. JHS/EDS-HT individuals were characterized by a non-physiological gait pattern. In particular, spatio-temporal parameters evidenced lower anterior step length and higher stance phase duration in JHS/EDS-HT than controls. In term of kinematics, in JHS/EDS-HT patients the main gait limitations involved pelvis, distal joints and ankle joint. Conversely, hip and knee joint showed physiological values. Ankle moment and power revealed reduced peak values during terminal stance. Differences in stiffness at hip and ankle joints were found between JHS/EDS-HT and controls. JHS/EDS-HT patients showed significant decreased of Kh and Ka parameters very probably due to congenital hypotonia and ligament laxity. These findings help to elucidate the complex biomechanical changes in JHS/EDS-HT and may have a major role in the multidimensional evaluation and tailored management of these patients.

  14. 3D-Flow processor for a programmable Level-1 trigger (feasibility study)

    SciTech Connect

    Crosetto, D.

    1992-10-01

    A feasibility study has been made to use the 3D-Flow processor in a pipelined programmable parallel processing architecture to identify particles such as electrons, jets, muons, etc., in high-energy physics experiments.

  15. Three-dimensional (3D) printed endovascular simulation models: a feasibility study

    PubMed Central

    Nesbitt, Craig; McCaslin, James; Bagnall, Alan; Davey, Philip; Bose, Pentop; Williams, Rob

    2017-01-01

    Background Three-dimensional (3D) printing is a manufacturing process in which an object is created by specialist printers designed to print in additive layers to create a 3D object. Whilst there are initial promising medical applications of 3D printing, a lack of evidence to support its use remains a barrier for larger scale adoption into clinical practice. Endovascular virtual reality (VR) simulation plays an important role in the safe training of future endovascular practitioners, but existing VR models have disadvantages including cost and accessibility which could be addressed with 3D printing. Methods This study sought to evaluate the feasibility of 3D printing an anatomically accurate human aorta for the purposes of endovascular training. Results A 3D printed model was successfully designed and printed and used for endovascular simulation. The stages of development and practical applications are described. Feedback from 96 physicians who answered a series of questions using a 5 point Likert scale is presented. Conclusions Initial data supports the value of 3D printed endovascular models although further educational validation is required. PMID:28251121

  16. Differentiating bladder carcinoma from bladder wall using 3D textural features: an initial study

    NASA Astrophysics Data System (ADS)

    Xu, Xiaopan; Zhang, Xi; Liu, Yang; Tian, Qiang; Zhang, Guopeng; Lu, Hongbing

    2016-03-01

    Differentiating bladder tumors from wall tissues is of critical importance for the detection of invasion depth and cancer staging. The textural features embedded in bladder images have demonstrated their potentials in carcinomas detection and classification. The purpose of this study was to investigate the feasibility of differentiating bladder carcinoma from bladder wall using three-dimensional (3D) textural features extracted from MR bladder images. The widely used 2D Tamura features were firstly wholly extended to 3D, and then different types of 3D textural features including 3D features derived from gray level co-occurrence matrices (GLCM) and grey level-gradient co-occurrence matrix (GLGCM), as well as 3D Tamura features, were extracted from 23 volumes of interest (VOIs) of bladder tumors and 23 VOIs of patients' bladder wall. Statistical results show that 30 out of 47 features are significantly different between cancer tissues and wall tissues. Using these features with significant differences between these two types of tissues, classification performance with a supported vector machine (SVM) classifier demonstrates that the combination of three types of selected 3D features outperform that of using only one type of features. All the observations demonstrate that significant textural differences exist between carcinomatous tissues and bladder wall, and 3D textural analysis may be an effective way for noninvasive staging of bladder cancer.

  17. Oxygen ingress study of 3D printed gaseous radiation detector enclosures

    SciTech Connect

    Steer, Christopher A.; Durose, Aaron

    2015-07-01

    As part of our ongoing studies into the potential application of 3D printing techniques to gaseous radiation detectors, we have studied the ability of 3D printed enclosures to resist environmental oxygen ingress. A set of cuboid and hexagonal prism shaped enclosures with wall thicknesses of 4 mm, 6 mm, 8 mm and 10 mm were designed and printed in nylon using a EOSINT P 730 Selective Laser Sintering 3D printer system These test enclosures provide a comparison of different environmental gas ingress for different 3D printing techniques. The rate of change of oxygen concentration was found to be linear, decreasing as the wall thickness increases. It was also found that the hexagonal prism geometry produced a lower rate of change of oxygen concentration compared with the cuboid shaped enclosures. Possible reasons as to why these results were obtained are discussed The implications for the this study for deployable systems are also discussed (authors)

  18. A study on radiative transfer effects in 3-D cloudy atmosphere using satellite data

    NASA Astrophysics Data System (ADS)

    Okata, M.; Nakajima, T.; Suzuki, K.; Inoue, T.; Nakajima, T. Y.; Okamoto, H.

    2017-01-01

    This study evaluates 3-D cloud effects on the radiation budget with a combined use of active sensor cloud profiling radar/CloudSat and imager Moderate Resolution Imaging Spectroradiometer/Aqua data on the A-train. An algorithm is devised for constructing 3-D cloud fields based on satellite-observed cloud information. The 3-D cloud fields thus constructed are used to calculate the broadband solar and thermal radiative fluxes with a 3-D radiative transfer code developed by the authors. The aim of this study is to investigate the effects of cloud morphology on solar radiative transfer in cloudy atmosphere. For this purpose, 3-D cloud fields are constructed with the new satellite-based method, to which full 3D-RT (radiative transfer) simulations are applied. The simulated 3-D radiation fields are then used to examine and quantify errors of existing typical plane-parallel approximations, i.e., Plane-Parallel Approximation, Independent Pixel Approximation and Tilted Independent Pixel Approximation. Such 3D-RT simulations also serve to address another objective of this study, i.e., to devise an accurate approximation and to characterize the observed specific 3D-RT effects by the cloud morphology based on knowledge of idealized 3D-RT effects. We introduce a modified approach based on an optimum value of diffusivity factor to better approximate the radiative fluxes for arbitrary solar zenith angle determined from the results of 3-D radiative transfer simulations to redeem the overcorrections of these approximations for large solar zenith angles (SZAs). This new approach, called Slant path Independent Pixel Approximation, is found to be better than other approximations when SZA is large for some cloud cases. Based on the SZA dependence of the errors of these approximations relative to 3-D computations, satellite-observed real cloud cases are found to fall into either of three types of different morphologies, i.e., isolated cloud type, upper cloud-roughened type and lower

  19. Computation of the 3D kinematics in a global frame over a 40m-long pathway using a rolling motion analysis system.

    PubMed

    Begon, Mickaël; Colloud, Floren; Fohanno, Vincent; Bahuaud, Pascal; Monnet, Tony

    2009-12-11

    A rolling motion analysis system has been purpose-built to acquire an accurate three-dimensional kinematics of human motion with large displacement. Using this device, the kinematics is collected in a local frame associated with the rolling motion analysis system. The purpose of this paper is to express the local kinematics of a subject walking on a 40 m-long pathway in a global system of co-ordinates. One participant performed five trials of walking while he was followed by a rolling eight camera optoelectronic motion analysis system. The kinematics of the trials were reconstructed in the global frame using two different algorithms and 82 markers placed on the floor organized in two parallel and horizontal lines. The maximal error ranged from 0.033 to 0.187 m (<0.5% of the volume diagonal). As a result, this device is accurate enough for acquiring the kinematics of cyclic activities with large displacements in ecological environment.

  20. Comparison of 2D versus 3D mammography with screening cases: an observer study

    NASA Astrophysics Data System (ADS)

    Fernandez, James Reza; Deshpande, Ruchi; Hovanessian-Larsen, Linda; Liu, Brent

    2012-02-01

    Breast cancer is the most common type of non-skin cancer in women. 2D mammography is a screening tool to aid in the early detection of breast cancer, but has diagnostic limitations of overlapping tissues, especially in dense breasts. 3D mammography has the potential to improve detection outcomes by increasing specificity, and a new 3D screening tool with a 3D display for mammography aims to improve performance and efficiency as compared to 2D mammography. An observer study using human studies collected from was performed to compare traditional 2D mammography with this new 3D mammography technique. A prior study using a mammography phantom revealed no difference in calcification detection, but improved mass detection in 2D as compared to 3D. There was a significant decrease in reading time for masses, calcifications, and normals in 3D compared to 2D, however, as well as more favorable confidence levels in reading normal cases. Data for this current study is currently being obtained, and a full report should be available in the next few weeks.

  1. Understanding the thermal history, exhumation patterns, and role of fault systems on Goodenough Island, Papua New Guinea: Insights from 3D thermo-kinematic modelling

    NASA Astrophysics Data System (ADS)

    Bermudez, M. A.; Baldwin, S.; Fitzgerald, P. G.; Braun, J.

    2012-12-01

    The world's youngest eclogites, exhumed from depths of ca. 90 km since 8 Ma, are located in the D'Entrecasteaux Islands in the active Woodlark rift of southeastern Papua New Guinea. These (U)HP rocks formed during/following subduction of Australian margin-derived volcaniclastic sediments, and were exhumed during rifting within the larger, obliquely convergent Australian-Pacific plate boundary zone. Several (U)HP exhumation mechanisms have been proposed including diapiric rise of buoyant crust from mantle to crustal depths, and rifting of heterogeneous crust ahead of the east-to-west propagating Woodlark seafloor spreading center. In order to constrain the relative importance of different exhumation mechanisms through time (i.e., timing and rates of diapirism vs crustal faulting), we apply 3D thermo-kinematic modeling (Pecube) to constrain cooling and exhumation histories derived from thermochronologic data from Goodenough Island, the western-most of the D'Entrecasteaux Islands. More than 500,000 Pecube inverse models were run to evaluate scenarios involving vertical exhumation velocities (i.e., simulating simple buoyancy due to diapirism), low-angle normal faulting and combinations of both processes. These preliminary models assume steady-state topography. Preliminary models (starting at 8 Ma) include: (i) continuous exhumation, (ii) two exhumation phases with different exhumation rates (increasing and/or decreasing), and (iii) three exhumation phases with variable exhumation rates. For buoyancy-only models, the first two scenarios (i and ii) result in poor fits between model-derived and observed (experimental) data. Notably, scenarios (i) and (ii) produce indistinguishable ages for all thermochronologic systems, uniformly long apatite fission-track (AFT) lengths, excessive temperatures at the Moho and geological starting parameters (depth, T) that are not consistent with other data. Scenario (iii) with three exhumation phases has the least misfit between model

  2. 3D current source density imaging based on acoustoelectric effect: a simulation study using unipolar pulses

    PubMed Central

    Yang, Renhuan; Li, Xu; Liu, Jun; He, Bin

    2011-01-01

    It is of importance to image electrical activity and properties of biological tissues. Recently hybrid imaging modality combing ultrasound scanning and source imaging through the acousto-electric (AE) effect has generated considerable interest. Such modality has the potential to provide high spatial resolution current density imaging by utilizing the pressure induced AE resistivity change confined at the ultrasound focus. In this study, we investigate a novel 3-dimensional (3D) ultrasound current source density imaging (UCSDI) approach using unipolar ultrasound pulses. Utilizing specially designed unipolar ultrasound pulses and by combining AE signals associated to the local resistivity changes at the focusing point, we are able to reconstruct the 3D current density distribution with the boundary voltage measurements obtained while performing a 3D ultrasound scan. We have shown in computer simulation that using the present method, it is feasible to image with high spatial resolution an arbitrary 3D current density distribution in an inhomogeneous conductive media. PMID:21628774

  3. Why 3D Cameras are Not Popular: A Qualitative User Study on Stereoscopic Photography Acceptance

    NASA Astrophysics Data System (ADS)

    Hakala, Jussi; Westman, Stina; Salmimaa, Marja; Pölönen, Monika; Järvenpää, Toni; Häkkinen, Jukka

    2014-03-01

    Digital stereoscopic 3D cameras have entered the consumer market in recent years, but the acceptance of this novel technology has not yet been studied. The aim of this study was to identify the benefits and problems that novice users encounter in 3D photography by equipping five users with 3D cameras for a 4-week trial. We gathered data using a weekly questionnaire, an exit interview, and a stereoscopic disparity analysis of the 699 photographs taken during the trial. The results indicate that the participants took photographs at too-close distances, which caused excessive disparities. They learned to avoid the problem to some extent; the number of failed photographs due to excessive stereoscopic disparity decreased 70 % in 4 weeks. The participants also developed a preference for subjects that included clear depth differences and started to avoid photographing people because they looked unnatural in 3D photographs. They also regarded flash-induced shadows and edge violations problematic because of the unnatural effects in the photographs. We propose in-camera assistance tools for 3D cameras to make 3D photography easier.

  4. The performance & flow visualization studies of three-dimensional (3-D) wind turbine blade models

    NASA Astrophysics Data System (ADS)

    Sutrisno, Prajitno, Purnomo, W., Setyawan B.

    2016-06-01

    Recently, studies on the design of 3-D wind turbine blades have a less attention even though 3-D blade products are widely sold. In contrary, advanced studies in 3-D helicopter blade tip have been studied rigorously. Studies in wind turbine blade modeling are mostly assumed that blade spanwise sections behave as independent two-dimensional airfoils, implying that there is no exchange of momentum in the spanwise direction. Moreover, flow visualization experiments are infrequently conducted. Therefore, a modeling study of wind turbine blade with visualization experiment is needed to be improved to obtain a better understanding. The purpose of this study is to investigate the performance of 3-D wind turbine blade models with backward-forward swept and verify the flow patterns using flow visualization. In this research, the blade models are constructed based on the twist and chord distributions following Schmitz's formula. Forward and backward swept are added to the rotating blades. Based on this, the additional swept would enhance or diminish outward flow disturbance or stall development propagation on the spanwise blade surfaces to give better blade design. Some combinations, i. e., b lades with backward swept, provide a better 3-D favorable rotational force of the rotor system. The performance of the 3-D wind turbine system model is measured by a torque meter, employing Prony's braking system. Furthermore, the 3-D flow patterns around the rotating blade models are investigated by applying "tuft-visualization technique", to study the appearance of laminar, separated, and boundary layer flow patterns surrounding the 3-dimentional blade system.

  5. Rapid prototyping for tissue-engineered bone scaffold by 3D printing and biocompatibility study

    PubMed Central

    He, Hui-Yu; Zhang, Jia-Yu; Mi, Xue; Hu, Yang; Gu, Xiao-Yu

    2015-01-01

    The prototyping of tissue-engineered bone scaffold (calcined goat spongy bone-biphasic ceramic composite/PVA gel) by 3D printing was performed, and the biocompatibility of the fabricated bone scaffold was studied. Pre-designed STL file was imported into the GXYZ303010-XYLE 3D printing system, and the tissue-engineered bone scaffold was fabricated by 3D printing using gel extrusion. Rabbit bone marrow stromal cells (BMSCs) were cultured in vitro and then inoculated to the sterilized bone scaffold obtained by 3D printing. The growth of rabbit BMSCs on the bone scaffold was observed under the scanning electron microscope (SEM). The effect of the tissue-engineered bone scaffold on the proliferation and differentiation of rabbit BMSCs using MTT assay. Universal testing machine was adopted to test the tensile strength of the bone scaffold. The leachate of the bone scaffold was prepared and injected into the New Zealand rabbits. Cytotoxicity test, acute toxicity test, pyrogenic test and intracutaneous stimulation test were performed to assess the biocompatibility of the bone scaffold. Bone scaffold manufactured by 3D printing had uniform pore size with the porosity of about 68.3%. The pores were well interconnected, and the bone scaffold showed excellent mechanical property. Rabbit BMSCs grew and proliferated on the surface of the bone scaffold after adherence. MTT assay indicated that the proliferation and differentiation of rabbit BMSCs on the bone scaffold did not differ significantly from that of the cells in the control. In vivo experiments proved that the bone scaffold fabricated by 3D printing had no acute toxicity, pyrogenic reaction or stimulation. Bone scaffold manufactured by 3D printing allows the rabbit BMSCs to adhere, grow and proliferate and exhibits excellent biomechanical property and high biocompatibility. 3D printing has a good application prospect in the prototyping of tissue-engineered bone scaffold. PMID:26380018

  6. Rapid prototyping for tissue-engineered bone scaffold by 3D printing and biocompatibility study.

    PubMed

    He, Hui-Yu; Zhang, Jia-Yu; Mi, Xue; Hu, Yang; Gu, Xiao-Yu

    2015-01-01

    The prototyping of tissue-engineered bone scaffold (calcined goat spongy bone-biphasic ceramic composite/PVA gel) by 3D printing was performed, and the biocompatibility of the fabricated bone scaffold was studied. Pre-designed STL file was imported into the GXYZ303010-XYLE 3D printing system, and the tissue-engineered bone scaffold was fabricated by 3D printing using gel extrusion. Rabbit bone marrow stromal cells (BMSCs) were cultured in vitro and then inoculated to the sterilized bone scaffold obtained by 3D printing. The growth of rabbit BMSCs on the bone scaffold was observed under the scanning electron microscope (SEM). The effect of the tissue-engineered bone scaffold on the proliferation and differentiation of rabbit BMSCs using MTT assay. Universal testing machine was adopted to test the tensile strength of the bone scaffold. The leachate of the bone scaffold was prepared and injected into the New Zealand rabbits. Cytotoxicity test, acute toxicity test, pyrogenic test and intracutaneous stimulation test were performed to assess the biocompatibility of the bone scaffold. Bone scaffold manufactured by 3D printing had uniform pore size with the porosity of about 68.3%. The pores were well interconnected, and the bone scaffold showed excellent mechanical property. Rabbit BMSCs grew and proliferated on the surface of the bone scaffold after adherence. MTT assay indicated that the proliferation and differentiation of rabbit BMSCs on the bone scaffold did not differ significantly from that of the cells in the control. In vivo experiments proved that the bone scaffold fabricated by 3D printing had no acute toxicity, pyrogenic reaction or stimulation. Bone scaffold manufactured by 3D printing allows the rabbit BMSCs to adhere, grow and proliferate and exhibits excellent biomechanical property and high biocompatibility. 3D printing has a good application prospect in the prototyping of tissue-engineered bone scaffold.

  7. The application of 3D image processing to studies of the musculoskeletal system

    NASA Astrophysics Data System (ADS)

    Hirsch, Bruce Elliot; Udupa, Jayaram K.; Siegler, Sorin; Winkelstein, Beth A.

    2009-10-01

    Three dimensional renditions of anatomical structures are commonly used to improve visualization, surgical planning, and patient education. However, such 3D images also contain information which is not readily apparent, and which can be mined to elucidate, for example, such parameters as joint kinematics, spacial relationships, and distortions of those relationships with movement. Here we describe two series of experiments which demonstrate the functional application of 3D imaging. The first concerns the joints of the ankle complex, where the usual description of motions in the talocrural joint is shown to be incomplete, and where the roles of the anterior talofibular and calcaneofibular ligaments are clarified in ankle sprains. Also, the biomechanical effects of two common surgical procedures for repairing torn ligaments were examined. The second series of experiments explores changes in the anatomical relationships between nerve elements and the cervical vertebrae with changes in neck position. They provide preliminary evidence that morphological differences may exist between asymptomatic subjects and patients with radiculopathy in certain positions, even when conventional imaging shows no difference.

  8. A kinematic study of finswimming at surface.

    PubMed

    Gautier, Jimmy; Baly, Laurent; Zanone, Pier-Giorgio; Watier, Bruno

    2004-06-01

    Finswimming is a sport of speed practiced on the surface or underwater, in which performance is based on whole-body oscillations. The present study investigated the undulatory motion performed by finswimmers at the surface. This study aiming to analyze the influence of the interaction of gender, practice level, and race distance on selected kinematic parameters. Six elite and six novices finswimmers equipped with joints markers (wrist, elbow, shoulder, hip, knee, and ankle) were recorded in the sagittal plane. The position of these anatomical marks was digitized at 50 Hz. An automated motion analysis software yielded velocity, vertical amplitude, frequency, and angular position. Results showed that stroke frequency decreased whereas the mean amplitude of all joints increased with increasing race distance (p < 0.01). Mean joint amplitude for the upper limbs (wrist, elbow and shoulder) was smaller for experts than for novices. Whereas that of the ankle was larger, so that the oscillation amplitude increased from shoulder to ankle. Elite male finswimmers were pitching more acutely than female. Moreover, elite male finswimmers showed a smaller knee bending than novices and than elite females (p < 0.01). This indicated that elite male finswimmers attempt to reduce drag forces thanks to a weak knee bending and a low upper limbs pitch. To sum up, gender, expertise, and race distance affect the performance and its kinematics in terms frontal drag. Expertise in finswimming requires taking advantage of the mechanical constraints pertaining to hydrodynamic constraints in order to optimize performance. Key PointsFinswimmers are at one and the same time a propelling and a propelled body. This study investigates the undulatory motion performed by finswimmers at the surface.Elite male finswimmers were pitching more acutely than female swimmers and showed a smaller knee bending than both novices and elite female swimmers.Finswimmers tended to perform a dolphin-like motion, which

  9. Receptor-based 3D-QSAR in Drug Design: Methods and Applications in Kinase Studies.

    PubMed

    Fang, Cheng; Xiao, Zhiyan

    2016-01-01

    Receptor-based 3D-QSAR strategy represents a superior integration of structure-based drug design (SBDD) and three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis. It combines the accurate prediction of ligand poses by the SBDD approach with the good predictability and interpretability of statistical models derived from the 3D-QSAR approach. Extensive efforts have been devoted to the development of receptor-based 3D-QSAR methods and two alternative approaches have been exploited. One associates with computing the binding interactions between a receptor and a ligand to generate structure-based descriptors for QSAR analyses. The other concerns the application of various docking protocols to generate optimal ligand poses so as to provide reliable molecular alignments for the conventional 3D-QSAR operations. This review highlights new concepts and methodologies recently developed in the field of receptorbased 3D-QSAR, and in particular, covers its application in kinase studies.

  10. Protein-protein interaction networks studies and importance of 3D structure knowledge.

    PubMed

    Lu, Hui-Chun; Fornili, Arianna; Fraternali, Franca

    2013-12-01

    Protein-protein interaction networks (PPINs) are a powerful tool to study biological processes in living cells. In this review, we present the progress of PPIN studies from abstract to more detailed representations. We will focus on 3D interactome networks, which offer detailed information at the atomic level. This information can be exploited in understanding not only the underlying cellular mechanisms, but also how human variants and disease-causing mutations affect protein functions and complexes' stability. Recent studies have used structural information on PPINs to also understand the molecular mechanisms of binding partner selection. We will address the challenges in generating 3D PPINs due to the restricted number of solved protein structures. Finally, some of the current use of 3D PPINs will be discussed, highlighting their contribution to the studies in genotype-phenotype relationships and in the optimization of targeted studies to design novel chemical compounds for medical treatments.

  11. Mitral valve analysis using a novel 3D holographic display: a feasibility study of 3D ultrasound data converted to a holographic screen.

    PubMed

    Beitnes, Jan Otto; Klæboe, Lars Gunnar; Karlsen, Jørn Skaarud; Urheim, Stig

    2015-02-01

    The aim of the present study was to test the feasibility of analyzing 3D ultrasound data on a novel holographic display. An increasing number of mini-invasive procedures for mitral valve repair require more effective visualization to improve patient safety and speed of procedures. A novel 3D holographic display has been developed and may have the potential to guide interventional cardiac procedures in the near future. Forty patients with degenerative mitral valve disease were analyzed. All had complete 2D transthoracic (TTE) and transoesophageal (TEE) echocardiographic examinations. In addition, 3D TTE of the mitral valve was obtained and recordings were converted from the echo machine to the holographic screen. Visual inspection of the mitral valve during surgery or TEE served as the gold standard. 240 segments were analyzed by 2 independent observers. A total of 53 segments were prolapsing. The majority included P2 (31), the remaining located at A2 (8), A3 (6), P3 (5), P1 (2) and A1 (1). The sensitivity and specificity of the 3D display was 87 and 99 %, respectively (observer I), and for observer II 85 and 97 %, respectively. The accuracies and precisions were 96.7 and 97.9 %, respectively, (observer I), 94.3 and 88.2 % (observer II), and inter-observer agreement was 0.954 with Cohen's Kappa 0.86. We were able to convert 3D ultrasound data to the holographic display. A very high accuracy and precision was shown, demonstrating the feasibility of analyzing 3D echo of the mitral valve on the holographic screen.

  12. Cancer Cytokines and the Relevance of 3D Cultures for Studying those Implicated in Human Cancers.

    PubMed

    Maddaly, Ravi; Subramaniyan, Aishwarya; Balasubramanian, Harini

    2017-03-06

    Cancers are complex conditions and involving several factors for oncogenesis and progression. Of the various factors influencing the physiology of cancers, cytokines are known to play significant roles as mediators of functions. Intricate cytokine networks have been identified in cancers and interest in cytokines associated with cancers has been gaining ground. Of late, some of these cytokines are even identified as potential targets for cancer therapy apart from a few others such as IL-6 being identified as markers for disease prognosis. Of the major contributors to cancer research, cancer cell lines occupy the top slot as the most widely used material in vitro. In vitro cell cultures have seen significant evolution by the introduction of 3 dimensional (3D) culture systems. 3D cell cultures are now widely accepted as excellent material for cancer research which surpasses the traditional monolayer cultures. Cancer research has benefitted from 3D cell cultures for understanding the various hallmarks of cancers. However, the potential of these culture systems are still unexploited for cancer cytokine research compared to the other aspects of cancers such as gene expression changes, drug-induced toxicity, morphology, angiogenesis and invasion. Considering the importance of cancer cytokines, 3D cell cultures can be better utilized in understanding their roles and functions. Some of the possibilities where 3D cell cultures can contribute to cancer cytokine research arise from the distinct morphology of the tumor spheroids, the extracellular matrix (ECM), and the spontaneous occurrence of nutrient and oxygen gradients. Also, the 3D culture models enable one to co-culture different types of cells as a simulation of in vivo conditions, enhancing their utility to study cancer cytokines. We review here the cancer associated cytokines the contributions of 3D cancer cell cultures for studying cancer cytokines. This article is protected by copyright. All rights reserved.

  13. Seeing biological actions in 3D: An fMRI study

    PubMed Central

    Jastorff, Jan; Abdollahi, Rouhollah O.; Fasano, Fabrizio

    2015-01-01

    Abstract Precise kinematics or body configuration cannot be recovered from visual input without disparity information. Yet, no imaging study has investigated the role of disparity on action observation. Here, we investigated the interaction between disparity and the main cues of biological motion, kinematics and configuration, in two fMRI experiments. Stimuli were presented as point‐light figures, depicting complex action sequences lasting 21 s. We hypothesized that interactions could occur at any of the three levels of the action observation network, comprising occipitotemporal, parietal and premotor cortex, with premotor cortex being the most likely location. The main effects of kinematics and configuration confirmed that the biological motion sequences activated all three levels of the action observation network, validating our approach. The interaction between configuration and disparity activated only premotor cortex, whereas interactions between kinematics and disparity occurred at all levels of the action observation network but were strongest at the premotor level. Control experiments demonstrated that these interactions could not be accounted for by low level motion in depth, task effects, spatial attention, or eye movements, including vergence. These results underscore the role of premotor cortex in action observation, and in imitating others or responding to their actions. Hum Brain Mapp 37:203–219, 2016. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. PMID:26510637

  14. Application of 3D photo-reconstruction in soil erosion studies

    NASA Astrophysics Data System (ADS)

    Castillo, Carlos; James, Michael; Pérez, Rafael; Gómez, Jose Alfonso

    2014-05-01

    3D photo-reconstruction (3D-PR) has been applied successfully to obtain elevation models using uncalibrated and nonmetric cameras for a range of geoscience applications (e.g. James and Robson, 2012), including gully erosion assessment (Castillo et al., 2012). However, its application in soil erosion studies is currently at the outset. The aim of this work is to compare 3D-PR with conventional techniques that have been employed traditionally for different purposes in soil erosion studies. In this preliminary work, we tested three applications that involve volume calculations: estimation of soil bulk density (BD), quantification of soil erosion at road banks (RB) and sedimentation rates behind check dams (CD). For each analysis, a PR field survey was carried out simultaneously with a conventional method (volume of water was used for BD, and total station surveys for RB and CD). For the 3D-PR technique, the accuracy as a function of the number of pictures taken was evaluated. In this study we explore the difference in the volume estimates between 3D-PR and conventional techniques as well as the time requirements for each method in order to compare their performance and optimal field of application.

  15. Description of an evaluation system for knee kinematics in ligament lesions, by means of optical tracking and 3D tomography☆☆☆

    PubMed Central

    Fernandes, Tiago Lazzaretti; Ribeiro, Douglas Badillo; da Rocha, Diogo Cristo; Albuquerque, Cyro; Pereira, César Augusto Martins; Pedrinelli, André; Hernandez, Arnaldo José

    2014-01-01

    Objective To describe and demonstrate the viability of a method for evaluating knee kinematics, by means of a continuous passive motion (CPM) machine, before and after anterior cruciate ligament (ACL) injury. Methods This study was conducted on a knee from a cadaver, in a mechanical pivot-shift simulator, with evaluations using optical tracking, and also using computed tomography. Results This study demonstrated the viability of a protocol for measuring the rotation and translation of the knee, using reproducible and objective tools (error < 0.2 mm). The mechanized provocation system of the pivot-shift test was independent of the examiner and always allowed the same angular velocity and traction of 20 N throughout the movement. Conclusion The clinical relevance of this method lies in making inferences about the in vivo behavior of a knee with an ACL injury and providing greater methodological quality in future studies for measuring surgical techniques with grafts in relatively close positions. PMID:26229854

  16. Computational study of 3-D hot-spot initiation in shocked insensitive high-explosive

    NASA Astrophysics Data System (ADS)

    Najjar, F. M.; Howard, W. M.; Fried, L. E.; Manaa, M. R.; Nichols, A., III; Levesque, G.

    2012-03-01

    High-explosive (HE) material consists of large-sized grains with micron-sized embedded impurities and pores. Under various mechanical/thermal insults, these pores collapse generating hightemperature regions leading to ignition. A hydrodynamic study has been performed to investigate the mechanisms of pore collapse and hot spot initiation in TATB crystals, employing a multiphysics code, ALE3D, coupled to the chemistry module, Cheetah. This computational study includes reactive dynamics. Two-dimensional high-resolution large-scale meso-scale simulations have been performed. The parameter space is systematically studied by considering various shock strengths, pore diameters and multiple pore configurations. Preliminary 3-D simulations are undertaken to quantify the 3-D dynamics.

  17. Comparative studies on gravisensitive protists on ground (2D and 3D clinostats) and in microgravity

    NASA Astrophysics Data System (ADS)

    Hemmersbach, Ruth; Strauch, Sebastian M.; Seibt, Dieter; Schuber, Marianne

    2006-09-01

    In order to prepare and support space experiments, 2D and 3D clinostats are widely applied to study the influence of simulated weightlessness on biological systems. In order to evaluate the results a comparison between the data obtained in simulation experiments and in real microgravity is necessary. We are currently analyzing the gravity-dependent behavior of the protists Paramecium biaurelia (ciliate) and Euglena gracilis (photosynthetic flagellate) on these different experimental platforms. So far, first results are presented concerning the behaviour of Euglena on a 2D fast rotating clinostat and a 3D clinostat as well as under real microgravity conditions (TEXUS sounding rocket flight), of Paramecium on a 2D clinostat and in microgravity. Our data show similar results during 2D and 3D clinorotation compared to real microgravity with respect to loss of orientation (gravitaxis) of Paramecium and Euglena and a decrease of linearity of the cell tracks of Euglena. However, the increase of the mean swimming velocities, especially during 3D clinorotation (Euglena) and 2D clinorotation of Paramecium might indicate a persisting mechanostimulation of the cells. Further studies including long-term 2D and 3D clinostat exposition will enable us to demonstrate the qualification of the applied simulation methods.

  18. Model studies of blood flow in basilar artery with 3D laser Doppler anemometer

    NASA Astrophysics Data System (ADS)

    Frolov, S. V.; Sindeev, S. V.; Liepsch, D.; Balasso, A.; Proskurin, S. G.; Potlov, A. Y.

    2015-03-01

    It is proposed an integrated approach to the study of basilar artery blood flow using 3D laser Doppler anemometer for identifying the causes of the formation and development of cerebral aneurysms. Feature of the work is the combined usage of both mathematical modeling and experimental methods. Described the experimental setup and the method of measurement of basilar artery blood flow, carried out in an interdisciplinary laboratory of Hospital Rechts der Isar of Technical University of Munich. The experimental setup used to simulate the blood flow in the basilar artery and to measure blood flow characteristics using 3D laser Doppler anemometer (3D LDA). Described a method of numerical studies carried out in Tambov State Technical University and the Bakoulev Center for Cardiovascular Surgery. Proposed an approach for sharing experimental and numerical methods of research to identify the causes of the basilar artery aneurysms.

  19. Studies of the 3D Structure of the Nucleon at Jlab

    SciTech Connect

    Avakian, Harut

    2016-07-01

    Studies of the 3D structure of the nucleon encoded in Transverse Momentum Dependent distribution and fragmentation functions of partons and Generalized Parton Distributions are among the key objectives of the JLab 12 GeV upgrade and the Electron Ion Collider. Main challenges in extracting 3D partonic distributions from precision measurements of hard scattering processes include clear understanding of leading twist QCD fundamentals, higher twist effects, and also correlations of hadron production in target and current fragmentation regions. In this contribution we discuss some ongoing studies and future measurements of spin-orbit correlations at Jefferson Lab.

  20. Data compression studies for NOAA Hyperspectral Environmental Suite (HES) using 3D integer wavelet transforms with 3D set partitioning in hierarchical trees

    NASA Astrophysics Data System (ADS)

    Huang, Bormin; Huang, Hung-Lung; Chen, Hao; Ahuja, Alok; Baggett, Kevin; Schmit, Timothy J.; Heymann, Roger W.

    2004-02-01

    The next-generation NOAA/NESDIS GOES-R hyperspectral sounder, now referred to as the HES (Hyperspectral Environmental Suite), will have hyperspectral resolution (over one thousand channels with spectral widths on the order of 0.5 wavenumber) and high spatial resolution (less than 10 km). Hyperspectral sounder data is a particular class of data requiring high accuracy for useful retrieval of atmospheric temperature and moisture profiles, surface characteristics, cloud properties, and trace gas information. Hence compression of these data sets is better to be lossless or near lossless. Given the large volume of three-dimensional hyperspectral sounder data that will be generated by the HES instrument, the use of robust data compression techniques will be beneficial to data transfer and archive. In this paper, we study lossless data compression for the HES using 3D integer wavelet transforms via the lifting schemes. The wavelet coefficients are processed with the 3D set partitioning in hierarchical trees (SPIHT) scheme followed by context-based arithmetic coding. SPIHT provides better coding efficiency than Shapiro's original embedded zerotree wavelet (EZW) algorithm. We extend the 3D SPIHT scheme to take on any size of 3D satellite data, each of whose dimensions need not be divisible by 2N, where N is the levels of the wavelet decomposition being performed. The compression ratios of various kinds of wavelet transforms are presented along with a comparison with the JPEG2000 codec.

  1. Lossless data compression studies for NOAA hyperspectral environmental suite using 3D integer wavelet transforms with 3D embedded zerotree coding

    NASA Astrophysics Data System (ADS)

    Huang, Bormin; Huang, Hung-Lung; Chen, Hao; Ahuja, Alok; Baggett, Kevin; Schmit, Timothy J.; Heymann, Roger W.

    2003-09-01

    Hyperspectral sounder data is a particular class of data that requires high accuracy for useful retrieval of atmospheric temperature and moisture profiles, surface characteristics, cloud properties, and trace gas information. Therefore compression of these data sets is better to be lossless or near lossless. The next-generation NOAA/NESDIS GOES-R hyperspectral sounder, now referred to as the HES (Hyperspectral Environmental Suite), will have hyperspectral resolution (over one thousand channels with spectral widths on the order of 0.5 wavenumber) and high spatial resolution (less than 10 km). Given the large volume of three-dimensional hyperspectral sounder data that will be generated by the HES instrument, the use of robust data compression techniques will be beneficial to data transfer and archive. In this paper, we study lossless data compression for the HES using 3D integer wavelet transforms via the lifting schemes. The wavelet coefficients are then processed with the 3D embedded zerotree wavelet (EZW) algorithm followed by context-based arithmetic coding. We extend the 3D EZW scheme to take on any size of 3D satellite data, each of whose dimensions need not be divisible by 2N, where N is the levels of the wavelet decomposition being performed. The compression ratios of various kinds of wavelet transforms are presented along with a comparison with the JPEG2000 codec.

  2. Carboxy-Methyl-Cellulose (CMC) hydrogel-filled 3-D scaffold: Preliminary study through a 3-D antiproliferative activity of Centella asiatica extract

    NASA Astrophysics Data System (ADS)

    Aizad, Syazwan; Yahaya, Badrul Hisham; Zubairi, Saiful Irwan

    2015-09-01

    This study focuses on the effects of using the water extract from Centella asiatica on the mortality of human lung cancer cells (A549) with the use of novel 3-D scaffolds infused with CMC hydrogel. A biodegradable polymer, poly (hydroxybutyrate-co-hydroxyvalerate) (PHBV) was used in this study as 3-D scaffolds, with some modifications made by introducing the gel structure on its pore, which provides a great biomimetic microenvironment for cells to grow apart from increasing the interaction between the cells and cell-bioactive extracts. The CMC showed a good hydrophilic characteristic with mean contact angle of 24.30 ± 22.03°. To ensure the CMC gel had good attachments with the scaffolds, a surface treatment was made before the CMC gel was infused into the scaffolds. The results showed that these modified scaffolds contained 42.41 ± 0.14% w/w of CMC gel, which indicated that the gel had already filled up the entire pore of 3-D scaffolds. Besides, the infused hydrogel scaffolds took only 24 hours to be saturated when absorbing the water. The viability of cancer cells by MTS assay after being treated with Centella asiatica showed that the scaffolds infused with CMC hydrogel had the cell viability of 46.89 ± 1.20% followed by porous 3-D model with 57.30 ± 1.60% of cell viability, and the 2-D model with 67.10 ± 1.10% of cell viability. The inhibitory activity in cell viability between 2-D and 3-D models did not differ significantly (p>0.05) due to the limitation of time in incubating the extract with the cell in the 3-D model microenvironment. In conclusion, with the application of 3-D scaffolds infused with CMC hydrogel, the extracts of Centella asiatica has been proven to have the ability to kill cancer cells and have a great potential to become one of the alternative methods in treating cancer patients.

  3. PRESAGETM - Development and optimization studies of a 3D radiochromic plastic dosimeter - Part 1

    NASA Astrophysics Data System (ADS)

    Adamovics, J.; Jordan, K.; Dietrich, J.

    2006-12-01

    This paper studies the polymerization of six different transparent plastics as potential 3D dosimeter matrices. In addition, six different leuco dyes and sixteen different free radical initiators were evaluated. Finally, the photoreactivity of the dosimeter was studied so that the effect of exposure to UV could be minimized.

  4. Best Practices for Designing Online Learning Environments for 3D Modeling Curricula: A Delphi Study

    ERIC Educational Resources Information Center

    Mapson, Kathleen Harrell

    2011-01-01

    The purpose of this study was to develop an inventory of best practices for designing online learning environments for 3D modeling curricula. Due to the instructional complexity of three-dimensional modeling, few have sought to develop this type of course for online teaching and learning. Considering this, the study aimed to collectively aggregate…

  5. 3D electrical structure of porphyry copper deposit: A case study of Shaxi copper deposit

    NASA Astrophysics Data System (ADS)

    Chen, Xiang-Bin; Lü, Qing-Tian; Yan, Jia-Yong

    2012-06-01

    Located in Lu-Zong ore concentration area, middle-lower Yangtze metallogenic belt, ShaXi porphyry copper deposit is a typical hydrothermal deposit. To investigate the distribution of deep ore bodies and spatial characteristics of host structures, an AMT survey was conducted in mining area. Eighteen pseudo-2D resistivity sections were constructed through careful processing and inversion. These sections clearly show resistivity difference between the Silurian sandstones formation and quartz diorite porphyry and this porphyry copper formation was controlled by the highly resistive anticlines. Using 3D block Kriging interpolation method and 3D visualization techniques, we constructed a detailed 3D resistivity model of quartz diorite porphyry which shows the shape and spatial distribution of deep ore bodies. This case study can serve as a good example for future ore prospecting in and around this mining area.

  6. Design, synthesis and 3D-QSAR study of cytotoxic flavonoid derivatives.

    PubMed

    Ou, Lili; Han, Shuang; Ding, Wenbo; Chen, Zhe; Ye, Ziqi; Yang, Hongyu; Zhang, Goulin; Lou, Yijia; Chen, Jian-Zhong; Yu, Yongping

    2011-08-01

    Three series of flavonoid derivatives were designed and synthesized. All synthesized compounds were evaluated for cytotoxic activities against five human cancer cell lines, including K562, PC-3, MCF-7, A549, and HO8910. Among the compounds tested, compound 9 d exhibited the most potent cytotoxic activity with IC(50) values of 2.76-6.98 μM. Further comparative molecular field analysis was performed to conduct a 3D quantitative structure-activity relationship study. The generated 3D-QSAR model could be used for further rational design of novel flavonoid analogs as highly potent cytotoxic agents.

  7. A Survey Study of the Blast Furnace at Kuangshan Village Using 3D Laser Scanning

    NASA Astrophysics Data System (ADS)

    Wang, Jin; Huang, Xing; Qian, Wei

    2017-01-01

    The blast furnace from the Northern Song Dynasty at Kuangshan Village is the tallest blast furnace that remains from ancient China. Previous studies have assumed that the furnace had a closed mouth. In this paper, a three-dimensional (3D) model of the blast furnace is constructed using 3D laser scanning technology, and accurate profile data are obtained using software. It is shown that the furnace throat is smaller than had been previously thought and that the furnace mouth is of the open type. This new furnace profile constitutes a discovery in the history of iron-smelting technology.

  8. 3D evaluation of palatal rugae for human identification using digital study models

    PubMed Central

    Taneva, Emilia D.; Johnson, Andrew; Viana, Grace; Evans, Carla A.

    2015-01-01

    Background: While there is literature suggesting that the palatal rugae could be used for human identification, most of these studies use two-dimensional (2D) approach. Aim: The aims of this study were to evaluate palatal ruga patterns using three-dimensional (3D) digital models; compare the most clinically relevant digital model conversion techniques for identification of the palatal rugae; develop a protocol for overlay registration; determine changes in palatal ruga individual patterns through time; and investigate the efficiency and accuracy of 3D matching processes between different individuals’ patterns. Material and Methods: Five cross sections in the anteroposterior dimension and four cross sections in the transverse dimension were computed which generated 18 2D variables. In addition, 13 3D variables were defined: The posterior point of incisive papilla (IP), and the most medial and lateral end points of the palatal rugae (R1MR, R1ML, R1LR, R1LL, R2MR, R2ML, R2LR, R2LL, R3MR, R3ML, R3LR, and R3LL). The deviation magnitude for each variable was statistically analyzed in this study. Five different data sets with the same 31 landmarks were evaluated in this study. Results: The results demonstrated that 2D images and linear measurements in the anteroposterior and transverse dimensions were not sufficient for comparing different digital model conversion techniques using the palatal rugae. 3D digital models proved to be a highly effective tool in evaluating different palatal ruga patterns. The 3D landmarks showed no statistically significant mean differences over time or as a result of orthodontic treatment. No statistically significant mean differences were found between different digital model conversion techniques, that is, between OrthoCAD™ and Ortho Insight 3D™, and between Ortho Insight 3D™ and the iTero® scans, when using 12 3D palatal rugae landmarks for comparison. Conclusion: Although 12 palatal 3D landmarks could be used for human

  9. Paper/PMMA Hybrid 3D Cell Culture Microfluidic Platform for the Study of Cellular Crosstalk.

    PubMed

    Lei, Kin Fong; Chang, Chih-Hsuan; Chen, Ming-Jie

    2017-04-06

    Studying cellular crosstalk is important for understanding tumor initiation, progression, metastasis, and therapeutic resistance. Moreover, a three-dimensional (3D) cell culture model can provide a more physiologically meaningful culture microenvironment. However, studying cellular crosstalk in a 3D cell culture model involves tedious processing. In this study, a paper/poly(methyl methacrylate) (PMMA) hybrid 3D cell culture microfluidic platform was successfully developed for the study of cellular crosstalk. The platform was a paper substrate with culture microreactors placed on a PMMA substrate with hydrogel-infused channels. Different types of cells were directly seeded and cultured in the microreactors. Aberrant cell proliferation of the affected cells was induced by secretions from transfected cells, and the proliferation ratios were investigated using a colorimetric method. The results showed that the responses of cellular crosstalk were different in different types of cells. Moreover, neutralizing and competitive assays were performed to show the functionality of the platform. Additionally, the triggered signaling pathways of the affected cells were directly analyzed by a subsequent immunoassay. The microfluidic platform provides a simple method for studying cellular crosstalk and the corresponding signaling pathways in a 3D culture model.

  10. 3-D Magnetotelluric studies of Pre-Cambrian basement beneath southern Alberta

    NASA Astrophysics Data System (ADS)

    Nieuwenhuis, G.; Unsworth, M.; Pana, D.; Craven, J.

    2012-12-01

    The Pre-Cambrian basement rocks beneath Alberta record the tectonic events that led to the assembly of Laurentia in the Proterozoic. Since these rocks are covered with younger sedimentary rocks, they must be investigated with geophysical methods. In the 1990s, these basement rocks were studied with a number of long-period magnetotelluric (MT) profiles collected by the Lithoprobe project. Dimensionality analysis of these data show that they appear to be two dimensional (2-D) in the period band 1-1000 s. However 2-D inversion models were unable to reproduce these MT data with a realistic resistivity model. The inversion models were very rough and characterized by many closely spaced conductors. Since the Lithoprobe data gave indications of 3-D resistivity structure, especially in the Archean Loverna block, additional MT data were collected by the University of Alberta from 2006-2010 using NIMS instruments. The goal was to develop an array that would constrain a fully 3-D model of crustal and upper mantle resistivity. The data at periods 1-10,000 s were inverted using a 3-D inversion algorithm. Comparisons between 2-D and 3-D inversions show that both models fit the measured MT data equally well. The 3-D model shows that the structure is dominated by an upper mantle conductor beneath the Loverna Block (the Loverna conductor). This conductor was previously imaged by the 2-D inversion of the Lithoprobe data. Our 3-D model shows that the Loverna conductor extends throughout the Archean Loverna block (part of the Hearne Domain) and is bounded to the south by a potential field anomaly known as the Vulcan Structure. Initial interpretations of the Vulcan Structure explained it as an intracontinental rift zone, while more recent studies show that it is more likely a north dipping subduction zone between two Archean blocks. This interpretation is supported by our 3-D resistivity model, which shows a good correlation between north dipping reflectors and the top of conductivity

  11. Impact of 3D root uptake on solute transport: a numerical study

    NASA Astrophysics Data System (ADS)

    Schröder, N.; Javaux, M.; Vanderborght, J.; Steffen, B.; Vereecken, H.

    2011-12-01

    Plant transpiration is an important component of the hydrological cycle. Through root water uptake, plants do not only affect the 3D soil water flow velocity distribution, but also solute movement in soil. This numerical study aims at investigating how solute fate is impacted by root uptake using the 3D biophysical model R-SWMS (Javaux et al., 2008). This model solves the Richards equation in 3D in the soil and the flow equation within the plant root xylem vessels. Furthermore, for solute transport simulations, the 3D particle tracker PARTRACE (Bechtold et al., 2011) was used. . We generated 3D virtual steady-state breakthrough curves (BTC) experiments in soils with transpiring plants. The averaged BTCs were then fitted with a 1D numerical flow model under steady-state conditions to obtain apparent CDE parameters. Two types of root architecture, a fibrous and a taprooted structure, were compared in virtual 3D experiments. The solute uptake type or the transpiration rate were also modified and we analyzed how these parameters affected apparent disperisivity and velocity profiles. Our simulation results show, that both, apparent velocity and dispersivity length are affected by water and solute root uptake. In addition, under high exclusion processes (slight or no active uptake), solute accumulates around roots and generates a long tailing to the breakthrough curves, which cannot be reproduced by 1D models that simulate root water uptake with solute exclusion. This observation may have an important impact on how to model pollutant mass transfer to groundwater at larger scales. Javaux, M., T. Schröder, J. Vanderborght, and H. Vereecken. 2008. Use of a three-dimensional detailed modeling approach for predicting root water uptake. Vadose Zone J. 7:1079-1088.doi: 10.2136/vzj2007.0115. Bechtold, M., S. Haber-Pohlmeier, J. Vanderborght, A. Pohlmeier, P.A. Ferre, and H. Vereecken. 2011. Near-surface solute redistribution during evaporation. Submitted to Geophys. Res. Lett

  12. Effect of mental fatigue caused by mobile 3D viewing on selective attention: an ERP study.

    PubMed

    Mun, Sungchul; Kim, Eun-Soo; Park, Min-Chul

    2014-12-01

    This study investigated behavioral responses to and auditory event-related potential (ERP) correlates of mental fatigue caused by mobile three-dimensional (3D) viewing. Twenty-six participants (14 women) performed a selective attention task in which they were asked to respond to the sounds presented at the attended side while ignoring sounds at the ignored side before and after mobile 3D viewing. Considering different individual susceptibilities to 3D, participants' subjective fatigue data were used to categorize them into two groups: fatigued and unfatigued. The amplitudes of d-ERP components were defined as differences in amplitudes between time-locked brain oscillations of the attended and ignored sounds, and these values were used to calculate the degree to which spatial selective attention was impaired by 3D mental fatigue. The fatigued group showed significantly longer response times after mobile 3D viewing compared to before the viewing. However, response accuracy did not significantly change between the two conditions, implying that the participants used a behavioral strategy to cope with their performance accuracy decrement by increasing their response times. No significant differences were observed for the unfatigued group. Analysis of covariance revealed group differences with significant and trends toward significant decreases in the d-P200 and d-late positive potential (LPP) amplitudes at the occipital electrodes of the fatigued and unfatigued groups. Our findings indicate that mentally fatigued participants did not effectively block out distractors in their information processing mechanism, providing support for the hypothesis that 3D mental fatigue impairs spatial selective attention and is characterized by changes in d-P200 and d-LPP amplitudes.

  13. Supporting Distributed Team Working in 3D Virtual Worlds: A Case Study in Second Life

    ERIC Educational Resources Information Center

    Minocha, Shailey; Morse, David R.

    2010-01-01

    Purpose: The purpose of this paper is to report on a study into how a three-dimensional (3D) virtual world (Second Life) can facilitate socialisation and team working among students working on a team project at a distance. This models the situation in many commercial sectors where work is increasingly being conducted across time zones and between…

  14. Segmented images and 3D images for studying the anatomical structures in MRIs

    NASA Astrophysics Data System (ADS)

    Lee, Yong Sook; Chung, Min Suk; Cho, Jae Hyun

    2004-05-01

    For identifying the pathological findings in MRIs, the anatomical structures in MRIs should be identified in advance. For studying the anatomical structures in MRIs, an education al tool that includes the horizontal, coronal, sagittal MRIs of entire body, corresponding segmented images, 3D images, and browsing software is necessary. Such an educational tool, however, is hard to obtain. Therefore, in this research, such an educational tool which helps medical students and doctors study the anatomical structures in MRIs was made as follows. A healthy, young Korean male adult with standard body shape was selected. Six hundred thirteen horizontal MRIs of the entire body were scanned and inputted to the personal computer. Sixty anatomical structures in the horizontal MRIs were segmented to make horizontal segmented images. Coronal, sagittal MRIs and coronal, sagittal segmented images were made. 3D images of anatomical structures in the segmented images were reconstructed by surface rendering method. Browsing software of the MRIs, segmented images, and 3D images was composed. This educational tool that includes horizontal, coronal, sagittal MRIs of entire body, corresponding segmented images, 3D images, and browsing software is expected to help medical students and doctors study anatomical structures in MRIs.

  15. 3D Visualization Types in Multimedia Applications for Science Learning: A Case Study for 8th Grade Students in Greece

    ERIC Educational Resources Information Center

    Korakakis, G.; Pavlatou, E. A.; Palyvos, J. A.; Spyrellis, N.

    2009-01-01

    This research aims to determine whether the use of specific types of visualization (3D illustration, 3D animation, and interactive 3D animation) combined with narration and text, contributes to the learning process of 13- and 14- years-old students in science courses. The study was carried out with 212 8th grade students in Greece. This…

  16. Zig-Zag Thermal-Chemical 3-D Instabilities in the Mantle Wedge: Numerical Study

    NASA Astrophysics Data System (ADS)

    Zhu, G.; Gerya, T. V.; Arcay, D.; Yuen, D. A.

    2008-12-01

    To understand the plume initiation and propagation it is important to understand whether small-scale convection is occurring under the back-arc in the Low Viscosity Wedge(LVW) and its implication on the island-arc volcanism. Honda et al. [Honda and Saito, 2003; Honda, et al., 2007]) already deployed small- scale convection in the Low Viscosity Wedge (LVW) above a subducting slab with kinematically imposed velocity boundary condition. They have suggested that a roll (finger)-like pattern of hot and cold anomalies emerges in the mantle wedge above the subducting slab. Here, we perform three-dimensional coupled petrological-thermomechanical numerical simulations of intraoceanic one-sided subduction with spontaneously bending retreating slab characterized by weak hydrated upper interface by using multigrid approach combined with characteristics-based marker-in-cell method with conservative finite difference schemes[Gerya and Yuen, 2003a], to investigate the 3D instabilities above the slab and lateral variation along the arc. Our results show that water released from subducting slab through dehydration reactions may lower the viscosity of the mantle. It allows the existence of wave-like small-scale convection in the LVW, which is shown as roll-like structure in 2D petrological-thermomechanical numerical experiments [Gorczyk et al., 2006] using in-situ rock properties computed on the basis of Gibbs free energy minimization. However, in our 3D cases, the rolls aligning with the arc mainly occur earlier , while zig-zag small-scale thermal-chemical instabilities may episodically form above the slab at later stages, which is different from the aligning finger-like pattern in purely thermal models (Honda et al,2003;2007). Also in contrast to thermal convection chemically buoyant hydrated plumes rising from the slab in our models are actually colder then the mantle wedge [Gerya and Yuen 2003b] which also strongly modify both the convection pattern and the seismic structure in

  17. 3D SEM for surface topography quantification - a case study on dental surfaces

    NASA Astrophysics Data System (ADS)

    Glon, F.; Flys, O.; Lööf, P.-J.; Rosén, B.-G.

    2014-03-01

    3D analysis of surface topography is becoming a more used tool for industry and research. New ISO standards are being launched to assist in quantifying engineering surfaces. The traditional optical measuring instrumentation used for 3D surface characterization has been optical interferometers and confocal based instrumentation. However, the resolution here is limited in the lateral dimension to the wavelength of visible light to about 500 nm. The great advantage using the SEM for topography measurements is the high flexibility to zoom from low magnifications and locating interesting areas to high magnification of down to nanometer large surface features within seconds. This paper presents surface characterization of dental implant micro topography. 3D topography data was created from SEM images using commercial photogrammetric software. A coherence scanning interferometer was used for reference measurements to compare with the 3D SEM measurements on relocated areas. As a result of this study, measurements emphasizes that the correlation between the accepted CSI measurements and the new technology represented by photogrammetry based on SEM images for many areal characterization parameters are around or less than 20%. The importance of selecting sampling and parameter sensitivity to varying sampling is high-lighted. Future work includes a broader study of limitations of the photogrammetry technique on certified micro-geometries and more application surfaces at different scales.

  18. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype.

    PubMed

    Cassereau, Luke; Miroshnikova, Yekaterina A; Ou, Guanqing; Lakins, Johnathon; Weaver, Valerie M

    2015-01-10

    Extracellular matrix (ECM) structure, composition, and stiffness have profound effects on tissue development and pathologies such as cardiovascular disease and cancer. Accordingly, a variety of synthetic hydrogel systems have been designed to study the impact of ECM composition, density, mechanics, and topography on cell and tissue phenotype. However, these synthetic systems fail to accurately recapitulate the biological properties and structure of the native tissue ECM. Natural three dimensional (3D) ECM hydrogels, such as collagen or hyaluronic acid, feature many of the chemical and physical properties of tissue, yet, these systems have limitations including the inability to independently control biophysical properties such as stiffness and pore size. Here, we present a 3D tension bioreactor system that permits precise mechanical tuning of collagen hydrogel stiffness, while maintaining consistent composition and pore size. We achieve this by mechanically loading collagen hydrogels covalently-conjugated to a polydimethylsiloxane (PDMS) membrane to induce hydrogel stiffening. We validated the biological application of this system with oncogenically transformed mammary epithelial cell organoids embedded in a 3D collagen I hydrogel, either uniformly stiffened or calibrated to create a gradient of ECM stiffening, to visually demonstrate the impact of ECM stiffening on transformation and tumor cell invasion. As such, this bioreactor presents the first tunable 3D natural hydrogel system that is capable of independently assessing the role of ECM stiffness on tissue phenotype.

  19. 3D Gravity Inversion of Northern Sinai Peninsula: A Case Study

    NASA Astrophysics Data System (ADS)

    Khalil, Mohamed A.; Santos, Fernando M.

    2014-07-01

    The Sinai Peninsula has attracted the attention of many geological and geophysical studies as it is influenced and bounded by major tectonic events. Those are (1) the Mesozoic to Early Cenozoic tectonically active opening of the Tethys, (2) the Late Cretaceous to Early Tertiary (Laramide) Syrian arc system, due to closing of the Tethys (3) the Oligo-Miocene Gulf of Suez rifted basin, and (4) the Late Miocene to Recent transform Dead Sea-Gulf of Aqaba rift. Additionally, the shear zones inside Sinai such as the Ragabet El-Naam and Minsherah-Abu Kandu Shear Zones. Each of these major tectonic events has affected dramatically the structure evolution of the northern Sinai area. The present paper estimates the 3D density contrast model using the gravity data of northern Sinai. The estimated 3D density contrast model elucidated the peculiarities of the main structural elements in the region. The estimated 3D density contrast model showed the high and low gravity anomalies that form the main mountains and main valleys in northern Sinai. The estimated low density zones are in agreement with the inferred faults resulting from the first horizontal derivative. Comparing the 3D model with the tectonic history of the region and the results of the first horizontal derivative and least square separation increased the reliability of the model.

  20. Validity Study of Vertebral Rotation Measurement Using 3-D Ultrasound in Adolescent Idiopathic Scoliosis.

    PubMed

    Wang, Qian; Li, Meng; Lou, Edmond H M; Chu, Winnie C W; Lam, Tsz-Ping; Cheng, Jack C Y; Wong, Man-Sang

    2016-07-01

    This study aimed to assess the validity of 3-D ultrasound measurements on the vertebral rotation of adolescent idiopathic scoliosis (AIS) under clinical settings. Thirty curves (mean Cobb angle: 21.7° ± 15.9°) from 16 patients with AIS were recruited. 3-D ultrasound and magnetic resonance imaging scans were performed at the supine position. Each of the two raters measured the apical vertebral rotation using the center of laminae (COL) method in the 3-D ultrasound images and the Aaro-Dahlborn method in the magnetic resonance images. The intra- and inter-reliability of the COL method was demonstrated by the intra-class correlation coefficient (ICC) (both [2, K] >0.9, p < 0.05). The COL method showed no significant difference (p < 0.05) compared with the Aaro-Dahlborn method. Furthermore, the agreement between these two methods was demonstrated by the Bland-Altman method, and high correlation was found (r > 0.9, p < 0.05). These results validated the proposed 3-D ultrasound method in the measurements of vertebral rotation in the patients with AIS.

  1. Studying Host-Pathogen Interactions In 3-D: Organotypic Models For Infectious Disease And Drug Development

    NASA Technical Reports Server (NTRS)

    Nickerson, Cheryl A.; Richter, Emily G.; Ott, C. Mark

    2006-01-01

    Representative, reproducible and high-throughput models of human cells and tissues are critical for a meaningful evaluation of host-pathogen interactions and are an essential component of the research developmental pipeline. The most informative infection models - animals, organ explants and human trials - are not suited for extensive evaluation of pathogenesis mechanisms and screening of candidate drugs. At the other extreme, more cost effective and accessible infection models such as conventional cell culture and static co-culture may not capture physiological and three-dimensional aspects of tissue biology that are important in assessing pathogenesis, and effectiveness and cytotoxicity of therapeutics. Our lab has used innovative bioengineering technology to establish biologically meaningful 3-D models of human tissues that recapitulate many aspects of the differentiated structure and function of the parental tissue in vivo, and we have applied these models to study infectious disease. We have established a variety of different 3-D models that are currently being used in infection studies - including small intestine, colon, lung, placenta, bladder, periodontal ligament, and neuronal models. Published work from our lab has shown that our 3-D models respond to infection with bacterial and viral pathogens in ways that reflect the infection process in vivo. By virtue of their physiological relevance, 3-D cell cultures may also hold significant potential as models to provide insight into the neuropathogenesis of HIV infection. Furthermore, the experimental flexibility, reproducibility, cost-efficiency, and high throughput platform afforded by these 3-D models may have important implications for the design and development of drugs with which to effectively treat neurological complications of HIV infection.

  2. 3D Echo Pilot Study of Geometric Left Ventricular Changes after Acute Myocardial Infarction

    PubMed Central

    Vieira, Marcelo Luiz Campos; Oliveira, Wercules Antonio; Cordovil, Adriana; Rodrigues, Ana Clara Tude; Mônaco, Cláudia Gianini; Afonso, Tânia; Lira Filho, Edgar Bezerra; Perin, Marco; Fischer, Cláudio Henrique; Morhy, Samira Saady

    2013-01-01

    Background Left ventricular remodeling (LVR) after AMI characterizes a factor of poor prognosis. There is little information in the literature on the LVR analyzed with three-dimensional echocardiography (3D ECHO). Objective To analyze, with 3D ECHO, the geometric and volumetric modifications of the left ventricle (VE) six months after AMI in patients subjected to percutaneous primary treatment. Methods Prospective study with 3D ECHO of 21 subjects (16 men, 56 ± 12 years-old), affected by AMI with ST segment elevation. The morphological and functional analysis (LV) with 3D ECHO (volumes, LVEF, 3D sphericity index) was carried out up to seven days and six months after the AMI. The LVR was considered for increase > 15% of the end diastolic volume of the LV (LVEDV) six months after the AMI, compared to the LVEDV up to seven days from the event. Results Eight (38%) patients have presented LVR. Echocardiographic measurements (n = 21 patients): I- up to seven days after the AMI: 1- LVEDV: 92.3 ± 22.3 mL; 2- LVEF: 0.51 ± 0.01; 3- sphericity index: 0.38 ± 0.05; II- after six months: 1- LVEDV: 107.3 ± 26.8 mL; 2- LVEF: 0.59 ± 0.01; 3- sphericity index: 0.31 ± 0.05. Correlation coefficient (r) between the sphericity index up to seven days after the AMI and the LVEDV at six months (n = 8) after the AMI: r: 0.74, p = 0.0007; (r) between the sphericity index six months after the AMI and the LVEDV at six months after the AMI: r: 0.85, p < 0.0001. Conclusion In this series, LVR has been observed in 38% of the patients six months after the AMI. The three-dimensional sphericity index has been associated to the occurrence of LVR. PMID:23740401

  3. 3D printed polyurethane prosthesis for partial tracheal reconstruction: a pilot animal study.

    PubMed

    Jung, Soo Yeon; Lee, Sang Jin; Kim, Ha Yeong; Park, Hae Sang; Wang, Zhan; Kim, Hyun Jun; Yoo, James J; Chung, Sung Min; Kim, Han Su

    2016-10-27

    A ready-made, acellular patch-type prosthesis is desirable in repairing partial tracheal defects in the clinical setting. However, many of these prostheses may not show proper biological integration and biomechanical function when they are transplanted. In this study, we developed a novel 3D printed polyurethane (PU) tracheal scaffold with micro-scale architecture to allow host tissue infiltration and adequate biomechanical properties to withstand physiological tracheal condition. A half-pipe shaped PU scaffold (1.8 cm of height, 0.18 cm thickness, and 2 cm of diameter) was fabricated by 3D printing of PU 200 μm PU beam. The 3D printed tracheal scaffolds consisted of a porous inner microstructure with 200 × 200 × 200 μm(3) sized pores and a non-porous outer layer. The mechanical properties of the scaffolds were 3.21 ± 1.02 MPa of ultimate tensile strength, 2.81 ± 0.58 MPa of Young's modulus, and 725% ± 41% of elongation at break. To examine the function of the 3D printed tracheal scaffolds in vivo, the scaffolds were implanted into 1.0 × 0.7 cm(2) sized anterior tracheal defect of rabbits. After implantation, bronchoscopic examinations revealed that the implanted tracheal scaffolds were patent for a 16 week-period. Histologic findings showed that re-epithelialization after 4 weeks of implantation and ciliated respiratory epithelium with ciliary beating after 8 weeks of implantation were observed at the lumen of the implanted tracheal scaffolds. The ingrowth of the connective tissue into the scaffolds was observed at 4 weeks after implantation. The biomechanical properties of the implanted tracheal scaffolds were continually maintained for 16 week-period. The results demonstrated that 3D printed tracheal scaffold could provide an alternative solution as a therapeutic treatment for partial tracheal defects.

  4. Adaptive clutter rejection for 3D color Doppler imaging: preliminary clinical study.

    PubMed

    Yoo, Yang Mo; Sikdar, Siddhartha; Karadayi, Kerem; Kolokythas, Orpheus; Kim, Yongmin

    2008-08-01

    In three-dimensional (3D) ultrasound color Doppler imaging (CDI), effective rejection of flash artifacts caused by tissue motion (clutter) is important for improving sensitivity in visualizing blood flow in vessels. Since clutter characteristics can vary significantly during volume acquisition, a clutter rejection technique that can adapt to the underlying clutter conditions is desirable for 3D CDI. We have previously developed an adaptive clutter rejection (ACR) method, in which an optimum filter is dynamically selected from a set of predesigned clutter filters based on the measured clutter characteristics. In this article, we evaluated the ACR method with 3D in vivo data acquired from 37 kidney transplant patients clinically indicated for a duplex ultrasound examination. We compared ACR against a conventional clutter rejection method, down-mixing (DM), using a commonly-used flow signal-to-clutter ratio (SCR) and a new metric called fractional residual clutter area (FRCA). The ACR method was more effective in removing the flash artifacts while providing higher sensitivity in detecting blood flow in the arcuate arteries and veins in the parenchyma of transplanted kidneys. ACR provided 3.4 dB improvement in SCR over the DM method (11.4 +/- 1.6 dB versus 8.0 +/- 2.0 dB, p < 0.001) and had lower average FRCA values compared with the DM method (0.006 +/- 0.003 versus 0.036 +/- 0.022, p < 0.001) for all study subjects. These results indicate that the new ACR method is useful for removing nonstationary tissue motion while improving the image quality for visualizing 3D vascular structure in 3D CDI.

  5. D Recording for 2d Delivering - the Employment of 3d Models for Studies and Analyses -

    NASA Astrophysics Data System (ADS)

    Rizzi, A.; Baratti, G.; Jiménez, B.; Girardi, S.; Remondino, F.

    2011-09-01

    In the last years, thanks to the advances of surveying sensors and techniques, many heritage sites could be accurately replicated in digital form with very detailed and impressive results. The actual limits are mainly related to hardware capabilities, computation time and low performance of personal computer. Often, the produced models are not visible on a normal computer and the only solution to easily visualized them is offline using rendered videos. This kind of 3D representations is useful for digital conservation, divulgation purposes or virtual tourism where people can visit places otherwise closed for preservation or security reasons. But many more potentialities and possible applications are available using a 3D model. The problem is the ability to handle 3D data as without adequate knowledge this information is reduced to standard 2D data. This article presents some surveying and 3D modeling experiences within the APSAT project ("Ambiente e Paesaggi dei Siti d'Altura Trentini", i.e. Environment and Landscapes of Upland Sites in Trentino). APSAT is a multidisciplinary project funded by the Autonomous Province of Trento (Italy) with the aim documenting, surveying, studying, analysing and preserving mountainous and hill-top heritage sites located in the region. The project focuses on theoretical, methodological and technological aspects of the archaeological investigation of mountain landscape, considered as the product of sequences of settlements, parcelling-outs, communication networks, resources, and symbolic places. The mountain environment preserves better than others the traces of hunting and gathering, breeding, agricultural, metallurgical, symbolic activities characterised by different lengths and environmental impacts, from Prehistory to the Modern Period. Therefore the correct surveying and documentation of this heritage sites and material is very important. Within the project, the 3DOM unit of FBK is delivering all the surveying and 3D material to

  6. 3D Propagation and Geoacoustic Inversion Studies in the Mid-Atlantic Bight

    DTIC Science & Technology

    2016-06-07

    3D Propagation and Geoacoustic Inversion Studies in the Mid-Atlantic Bight Kevin B. Smith Code PH/Sk, Department of Physics Naval Postgraduate...properties and measured transmission loss. Results from this analysis will be considered in the context of geoacoustic inversions . OBJECTIVES To...bathymetric features and ocean fronts near the shelf break of the mid-Atlantic Bight, and use of various data for geoacoutic inversion studies. The results

  7. Reconstruction of quadratic curves in 3D using two or more perspective views: simulation studies

    NASA Astrophysics Data System (ADS)

    Kumar, Sanjeev; Sukavanam, N.; Balasubramanian, R.

    2006-01-01

    The shapes of many natural and man-made objects have planar and curvilinear surfaces. The images of such curves usually do not have sufficient distinctive features to apply conventional feature-based reconstruction algorithms. In this paper, we describe a method of reconstruction of a quadratic curve in 3-D space as an intersection of two cones containing the respective projected curve images. The correspondence between this pair of projections of the curve is assumed to be established in this work. Using least-square curve fitting, the parameters of a curve in 2-D space are found. From this we are reconstructing the 3-D quadratic curve. Relevant mathematical formulations and analytical solutions for obtaining the equation of reconstructed curve are given. The result of the described reconstruction methodology are studied by simulation studies. This reconstruction methodology is applicable to LBW decision in cricket, path of the missile, Robotic Vision, path lanning etc.

  8. In vitro systems to study nephropharmacology: 2D versus 3D models.

    PubMed

    Sánchez-Romero, Natalia; Schophuizen, Carolien M S; Giménez, Ignacio; Masereeuw, Rosalinde

    2016-11-05

    The conventional 2-dimensional (2D) cell culture is an invaluable tool in, amongst others, cell biology and experimental pharmacology. However, cells cultured in 2D, on the top of stiff plastic plates lose their phenotypical characteristics and fail in recreating the physiological environment found in vivo. This is a fundamental requirement when the goal of the study is to get a rigorous predictive response of human drug action and safety. Recent approaches in the field of renal cell biology are focused on the generation of 3D cell culture models due to the more bona fide features that they exhibit and the fact that they are more closely related to the observed physiological conditions, and better predict in vivo drug handling. In this review, we describe the currently available 3D in vitro models of the kidney, and some future directions for studying renal drug handling, disease modeling and kidney regeneration.

  9. Motor control of voluntary arm movements. Kinematic and modelling study.

    PubMed

    Corradini, M L; Gentilucci, M; Leo, T; Rizzolatti, G

    1992-01-01

    The motor control of pointing and reaching-to-grasp movements was investigated using two different approaches (kinematic and modelling) in order to establish whether the type of control varies according to modifications of arm kinematics. Kinematic analysis of arm movements was performed on subjects' hand trajectories directed to large and small stimuli located at two different distances. The subjects were required either to grasp and to point to each stimulus. The kinematics of the subsequent movement, during which subject's hand came back to the starting position, were also studied. For both movements, kinematic analysis was performed on hand linear trajectories as well as on joint angular trajectories of shoulder and elbow. The second approach consisted in the parametric identification of the black box (ARMAX) model of the controller driving the arm movement. Such controller is hypothesized to work for the correct execution of the motor act. The order of the controller ARMAX model was analyzed with respect to the different experimental conditions (distal task, stimulus size and distance). Results from kinematic analysis showed that target distance and size influenced kinematic parameters both of angular and linear displacements. Nevertheless, the structure of the motor program was found to remain constant with distance and distal task, while it varied with precision requirements due to stimulus size. The estimated model order of the controller confirmed the invariance of the control law with regard to movement amplitude, whereas it was sensitive to target size.

  10. Two Eyes, 3D: A New Project to Study Stereoscopy in Astronomy Education

    NASA Astrophysics Data System (ADS)

    Price, Aaron; SubbaRao, M.; Wyatt, R.

    2012-01-01

    "Two Eyes, 3D" is a 3-year NSF funded research project to study the educational impacts of using stereoscopic representations in informal settings. The project funds two experimental studies. The first is focused on how children perceive various spatial qualities of scientific objects displayed in static 2D and 3D formats. The second is focused on how adults perceive various spatial qualities of scientific objects and processes displayed in 2D and 3D movie formats. As part of the project, two brief high-definition films about variable stars will be developed. Both studies will be mixed-method and look at prior spatial ability and other demographic variables as covariates. The project is run by the American Association of Variable Star Observers, Boston Museum of Science and the Adler Planetarium and Astronomy Museum with consulting from the California Academy of Sciences. Early pilot results will be presented. All films will be released into the public domain, as will the assessment software designed to run on tablet computers (iOS or Android).

  11. A porous 3D cell culture micro device for cell migration study.

    PubMed

    Ma, Liang; Zhou, Changchun; Lin, Biaoyang; Li, Wei

    2010-08-01

    Cell migration under chemoattractant is an important biological step in cancer metastasis that causes the spread of malignant tumor cells. Porous polymeric materials are widely used to mimic the extracellular matrix (ECM) environment for applications such as three dimensional (3D) cell culturing and tissue engineering. In this paper we report a novel 3D cell culture device based on porous polymeric material to study cancer migration. We fabricated a porous channel on a polymeric chip using a selective ultrasonic foaming method. We demonstrate that a chemical concentration gradient could be established through the porous channel due to the slow diffusion process. We show that significant cell migration could be observed through the porous channel within 1-2 weeks of cell culturing when metastatic M4A4-GFP breast cancer cells were induced by 20% fetal bovine serum (FBS).We also developed a mathematical model to evaluate the diffusivity and concentration gradient through the fabricated porous structure.

  12. 3D Ultrasound Guidance of Autonomous Robotic Breast Biopsy: Feasibility Study

    PubMed Central

    Liang, Kaicheng; Rogers, Albert J.; Light, Edward D.; von Allmen, Daniel; Smith, Stephen W.

    2009-01-01

    Feasibility studies of autonomous robot biopsies in tissue have been conducted using real time 3D ultrasound combined with simple thresholding algorithms. The robot first autonomously processed 3D image volumes received from the ultrasound scanner to locate a metal rod target embedded in turkey breast tissue simulating a calcification, and in a separate experiment, the center of a water-filled void in the breast tissue simulating a cyst. In both experiments the robot then directed a needle to the desired target, with no user input required. Separate needle-touch experiments performed by the image-guided robot in a water tank yielded an rms error of 1.15 mm. PMID:19900753

  13. The use of a low cost 3D scanning and printing tool in the manufacture of custom-made foot orthoses: a preliminary study

    PubMed Central

    2014-01-01

    Background Custom foot orthoses are currently recognized as the gold standard for treatment of foot and lower limb pathology. While foam and plaster casting methods are most widely used in clinical practice, technology has emerged, permitting the use of 3D scanning, computer aided design (CAD) and computer aided manufacturing (CAM) for fabrication of foot molds and custom foot orthotic components. Adoption of 3D printing, as a form of CAM, requires further investigation for use as a clinical tool. This study provides a preliminary description of a new method to manufacture foot orthoses using a novel 3D scanner and printer and compare gait kinematic outputs from shod and traditional plaster casted orthotics. Findings One participant (male, 25 years) was included with no lower extremity injuries. Foot molds were created from both plaster casting and 3D scanning/printing methods. Custom foot orthoses were then fabricated from each mold. Lower body plug-in-gait with the Oxford Foot Model on the right foot was collected for both orthotic and control (shod) conditions. The medial longitudinal arch was measured using arch height index (AHI) where a decrease in AHI represented a drop in arch height. The lowest AHI was 21.2 mm in the running shoes, followed by 21.4 mm wearing the orthoses made using 3D scanning and printing, with the highest AHI of 22.0 mm while the participant wore the plaster casted orthoses. Conclusion This preliminary study demonstrated a small increase in AHI with the 3D printing orthotic compared to the shod condition. A larger sample size may demonstrate significant patterns for the tested conditions. PMID:25015013

  14. 3D Bioprinting a Cell-Laden Bone Matrix for Breast Cancer Metastasis Study.

    PubMed

    Zhou, Xuan; Zhu, Wei; Nowicki, Margaret; Miao, Shida; Cui, Haitao; Holmes, Benjamin; Glazer, Robert I; Zhang, Lijie Grace

    2016-11-09

    Metastasis is one of the deadliest consequences of breast cancer, with bone being one of the primary sites of occurrence. Insufficient 3D biomimetic models currently exist to replicate this process in vitro. In this study, we developed a biomimetic bone matrix using 3D bioprinting technology to investigate the interaction between breast cancer (BrCa) cells and bone stromal cells (fetal osteoblasts and human bone marrow mesenchymal stem cells (MSCs)). A tabletop stereolithography 3D bioprinter was employed to fabricate a series of bone matrices consisting of osteoblasts or MSCs encapsulated in gelatin methacrylate (GelMA) hydrogel with nanocrystalline hydroxyapatite (nHA). When BrCa cells were introduced into the stromal cell-laden bioprinted matrices, we found that the growth of BrCa cells was enhanced by the presence of osteoblasts or MSCs, whereas the proliferation of the osteoblasts or MSCs was inhibited by the BrCa cells. The BrCa cells co-cultured with MSCs or osteoblasts presented increased vascular endothelial growth factor (VEGF) secretion in comparison to that of monocultured BrCa cells. Additionally, the alkaline phosphatase activity of MSCs or osteoblasts was reduced after BrCa cell co-culture. These results demonstrate that the 3D bioprinted matrix, with BrCa cells and bone stromal cells, provides a suitable model with which to study the interactive effects of cells in the context of an artificial bone microenvironment and thus may serve as a valuable tool for the investigation of postmetastatic breast cancer progression in bone.

  15. An Experimental Study of Mixing Dynamics in 3D Granular Flows

    NASA Astrophysics Data System (ADS)

    Zaman, Zafir

    Compared with the mixing of fluids, the mixing and segregation of granular materials remains one of the big questions of science. Unlike fluids, granular materials segregate based on differences in particle properties, such as density and size. For 2D granular flows, a dynamical systems framework has been effective in describing regions of mixing and segregation. However, computational and theoretical results are just starting to form a framework for 3D granular flows, such as the bi-axial spherical tumbler (BST) flow. This thesis builds on this emerging framework through a series of experimental studies with theoretical and model support with the goal of better understanding 3D mixing. The first study tests the commonly used assumption in continuum models of granular flow that single axis tumbler flow is two dimensional. Utilizing both surface and destructive subsurface imaging, this study shows that weak 3D deviations occur in the form of an axial drift within single axis tumbler flow of varying material spanwise depth. Afterward, this thesis focuses on the development of a custom-built X-ray imaging system to non-destructively visualize the tumbler subsurface. The second study revisits the axial drift and demonstrates that wall roughness impacts the curvature and overall displacement of particle trajectories throughout the tumbler domain using subsurface particle trajectories provided by the X-ray imaging system. Finally, mixing in the fully 3D BST flow is studied. In particular, 3D persistent mixing barriers that are predicted by the dynamical systems framework are shown to exist. Some barriers are remarkably persistent for as much as 500 protocol iterations despite the presence of collisional diffusion. The structures arise from two competing effects, the cutting and shuffling action of the protocol and the stretching from the flowing layer. The tumbling protocol controls the mixing behavior as well as the types of non-mixing barriers observed. Supplementary

  16. Intracranial Catheter for Integrated 3D Ultrasound Imaging & Hyperthermia: Feasibility Study

    NASA Astrophysics Data System (ADS)

    Herickhoff, Carl D.; Light, Edward D.; Bing, Kristin Frinkley; Mukundan, Srinivasan; Grant, Gerald A.; Wolf, Patrick D.; Dixon-Tulloch, Ellen; Shih, Timothy; Hsu, Stephen J.; Smith, Stephen W.

    2009-04-01

    In this study, we investigated the feasibility of an intracranial catheter transducer capable of real-time 3D (RT3D) imaging and ultrasound hyperthermia, for application in the visualization and treatment of tumors in the brain. We designed and constructed a 12 Fr, integrated matrix and linear array catheter transducer prototype for combined RT3D imaging and heating capability. This dual-mode catheter incorporated 153 matrix array elements and 11 linear array elements, on a 0.2 mm pitch, with a total aperture size of 8.4 mm×2.3 mm. This array achieved a 3.5° C in vitro temperature rise at a 2 cm focal distance in tissue-mimicking material. The dual-mode catheter prototype was compared with a Siemens 10 Fr AcuNav™ catheter as a gold standard in experiments assessing image quality and therapeutic potential, and both probes were used in a canine brain model to image anatomical structures and color Doppler blood flow and to attempt in vivo heating.

  17. Quantification of blood perfusion using 3D power Doppler: an in-vitro flow phantom study

    NASA Astrophysics Data System (ADS)

    Raine-Fenning, N. J.; Ramnarine, K. V.; Nordin, N. M.; Campbell, B. K.

    2004-01-01

    Three-dimensional (3D) power Doppler data is increasingly used to assess and quantify blood flow and tissue perfusion. The objective of this study was to assess the validity of common 3D power Doppler ‘vascularity’ indices by quantification in well characterised in-vitro flow models. A computer driven gear pump was used to circulate a steady flow of a blood mimicking fluid through various well characterised flow phantoms to investigate the effect of the number of flow channels, flow rate, depth dependent tissue attenuation, blood mimic scatter particle concentration and ultrasound settings. 3D Power Doppler data were acquired with a Voluson 530D scanner and 7.5 MHz transvaginal transducer (GE Kretz). Virtual Organ Computer-aided Analysis software (VOCAL) was used to quantify the vascularisation index (VI), flow index (FI) and vascularisation-flow index (VFI). The vascular indices were affected by many factors, some intuitive and some with more complex or unexpected relationships (e.g. VI increased linearly with an increase in flow rate, blood mimic scatter particle concentration and number of flow channels, and had a complex dependence on pulse repetition frequency). Use of standardised settings and appropriate calibration are required in any attempt at relating ‘vascularity indices’ with flow.

  18. An in vitro 3D model using collagen coated gelatin nanofibers for studying breast cancer metastasis.

    PubMed

    Janani, G; Pillai, Mamatha M; Selvakumar, R; Bhattacharyya, Amitava; Sabarinath, C

    2017-02-07

    The study of breast cancer metastasis is limited due to poor knowledge of molecular progression of breast tumor and varied heterogeneity. For a better understanding of tumor metastasis, a reliable 3D in vitro model bridging the gap between 2D cultures and in vivo animal model studies is essential. Our study is focused on two key points: (i) designing a 3D microenvironment for studying metastasis and (ii) simulating the metastasis milieu by inducing epithelial to mesenchymal transition (EMT) and mesenchymal to epithelial transition (MET). An electrospun gelatin nanofiber matrix (EGNF) was fabricated using electrospinning and further dip coated with different concentrations of collagen to obtain surface complexity and mechanical properties, similar to connective tissues. Nanofiber matrices were physically characterized by Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), and field-emission scanning electron microscopy (FESEM). The FTIR, AFM, and FESEM results indicated the crosslinking and confirmed the presence of pores in the nanofiber matrices. Comparative studies on biocompatibility, cell attachment, and the proliferation of MCF-7 cells on EGNF and collagen coated gelatin nanofibrous matrix (CCGM) revealed higher cellular attachment and proliferation in CCGM. CCGM with human metastatic breast cancer cell line (MCF-7) was taken to study breast cancer metastasis using estrogen (induces EMT) and progesterone (induces MET) hormones for 24 h. Quantitative real-time PCR was used for quantifying the expression of metastasis related genes, and fluorescence microscopy for verifying the invasion of cells to the matrices. The expression of E-cadherin and matrix metalloproteinase 2 (MMP 2) confirmed the occurrence of EMT and MET. Live cell imaging and cellular attachment showed significant increase of cellular invasion in crosslinked 0.15% CCGM that serves as a suitable non-toxic, biocompatible, and affordable scaffold for studying breast cancer

  19. 3-D QSAR studies on histone deacetylase inhibitors. A GOLPE/GRID approach on different series of compounds.

    PubMed

    Ragno, Rino; Simeoni, Silvia; Valente, Sergio; Massa, Silvio; Mai, Antonello

    2006-01-01

    Docking simulation and three-dimensional quantitative structure-activity relationships (3D-QSARs) analyses were conducted on four series of HDAC inhibitors. The studies were performed using the GRID/GOLPE combination using structure-based alignment. Twelve 3-D QSAR models were derived and discussed. Compared to previous studies on similar inhibitors, the present 3-D QSAR investigation proved to be of higher statistical value, displaying for the best global model r2, q2, and cross-validated SDEP values of 0.94, 0.83, and 0.41, respectively. A comparison of the 3-D QSAR maps with the structural features of the binding site showed good correlation. The results of 3D-QSAR and docking studies validated each other and provided insight into the structural requirements for anti-HDAC activity. To our knowledge this is the first 3-D QSAR application on a broad molecular diversity training set of HDACIs.

  20. A 3-D Computational Study of a Variable Camber Continuous Trailing Edge Flap (VCCTEF) Spanwise Segment

    NASA Technical Reports Server (NTRS)

    Kaul, Upender K.; Nguyen, Nhan T.

    2015-01-01

    Results of a computational study carried out to explore the effects of various elastomer configurations joining spanwise contiguous Variable Camber Continuous Trailing Edge Flap (VCCTEF) segments are reported here. This research is carried out as a proof-of-concept study that will seek to push the flight envelope in cruise with drag optimization as the objective. The cruise conditions can be well off design such as caused by environmental conditions, maneuvering, etc. To handle these off-design conditions, flap deflection is used so when the flap is deflected in a given direction, the aircraft angle of attack changes accordingly to maintain a given lift. The angle of attack is also a design parameter along with the flap deflection. In a previous 2D study,1 the effect of camber was investigated and the results revealed some insight into the relative merit of various camber settings of the VCCTEF. The present state of the art has not advanced sufficiently to do a full 3-D viscous analysis of the whole NASA Generic Transport Model (GTM) wing with VCCTEF deployed with elastomers. Therefore, this study seeks to explore the local effects of three contiguous flap segments on lift and drag of a model devised here to determine possible trades among various flap deflections to achieve desired lift and drag results. Although this approach is an approximation, it provides new insights into the "local" effects of the relative deflections of the contiguous spanwise flap systems and various elastomer segment configurations. The present study is a natural extension of the 2-D study to assess these local 3-D effects. Design cruise condition at 36,000 feet at free stream Mach number of 0.797 and a mean aerodynamic chord (MAC) based Reynolds number of 30.734x10(exp 6) is simulated for an angle of attack (AoA) range of 0 to 6 deg. In the previous 2-D study, the calculations revealed that the parabolic arc camber (1x2x3) and circular arc camber (VCCTEF222) offered the best L

  1. Monte Carlo generators for studies of the 3D structure of the nucleon

    DOE PAGES

    Avakian, Harut; D'Alesio, U.; Murgia, F.

    2015-01-23

    In this study, extraction of transverse momentum and space distributions of partons from measurements of spin and azimuthal asymmetries requires development of a self consistent analysis framework, accounting for evolution effects, and allowing control of systematic uncertainties due to variations of input parameters and models. Development of realistic Monte-Carlo generators, accounting for TMD evolution effects, spin-orbit and quark-gluon correlations will be crucial for future studies of quark-gluon dynamics in general and 3D structure of the nucleon in particular.

  2. 2D and 3D Terahertz Imaging and X-Rays CT for Sigillography Study

    NASA Astrophysics Data System (ADS)

    Fabre, M.; Durand, R.; Bassel, L.; Recur, B.; Balacey, H.; Bou Sleiman, J.; Perraud, J.-B.; Mounaix, P.

    2017-04-01

    Seals are part of our cultural heritage but the study of these objects is limited because of their fragility. Terahertz and X-Ray imaging are used to analyze a collection of wax seals from the fourteenth to eighteenth centuries. In this work, both techniques are compared in order to discuss their advantages and limits and their complementarity for conservation state study of the samples. Thanks to 3D analysis and reconstructions, defects and fractures are detected with an estimation of their depth position. The path from the parchment tongue inside the seals is also detected.

  3. 2D and 3D Terahertz Imaging and X-Rays CT for Sigillography Study

    NASA Astrophysics Data System (ADS)

    Fabre, M.; Durand, R.; Bassel, L.; Recur, B.; Balacey, H.; Bou Sleiman, J.; Perraud, J.-B.; Mounaix, P.

    2017-01-01

    Seals are part of our cultural heritage but the study of these objects is limited because of their fragility. Terahertz and X-Ray imaging are used to analyze a collection of wax seals from the fourteenth to eighteenth centuries. In this work, both techniques are compared in order to discuss their advantages and limits and their complementarity for conservation state study of the samples. Thanks to 3D analysis and reconstructions, defects and fractures are detected with an estimation of their depth position. The path from the parchment tongue inside the seals is also detected.

  4. A feasibility study of hand kinematics for EVA analysis using magnetic resonance imaging

    NASA Technical Reports Server (NTRS)

    Dickenson, Reuben D.; Lorenz, Christine H.; Peterson, Steven W.; Strauss, Alvin M.; Main, John A.

    1992-01-01

    A new method for analyzing the kinematics of joint motion using magnetic resonance imaging (MRI) is described. The reconstruction of the metacarpalphalangeal joint of the left index finger into a 3D graphic display is shown. From the reconstructed volumetric images, measurements of the angles of movement of the applicable bones are obtained and processed by analyzing the screw motion of the joint. Landmark positions are chosen at distinctive locations of the joint at fixed image threshold intensity levels to ensure repeatability. The primarily 2D planar motion of this joint is then studied using a method of constructing coordinate systems using three or more points. A transformation matrix based on a world coordinate system describes the location and orientation of the local target coordinate system. The findings show the applicability of MRI to joint kinematics for gaining further knowledge of the hand-glove design for EVA.

  5. Study of the kinematic and dynamic characteristics of a wormgear transmission for helicopter applications

    NASA Technical Reports Server (NTRS)

    Sun, D. C.; Yuan, Qin

    1994-01-01

    The first phase of the study of the performance of a wormgear transmission is reported. In this phase the work included the selection of a double-enveloping wormgear type, and its dimensions, suitable for use in helicopter transmissions; the 3-D graphics representation of the selected wormgear using the I-DEAS software; the analysis of the kinematics of meshing; the analysis of load sharing among the meshing teeth; and the implementation of the analyses in a computer program. The report describes the analyses, their results, and the use of the computer programs.

  6. Comparison of User Performance with Interactive and Static 3d Visualization - Pilot Study

    NASA Astrophysics Data System (ADS)

    Herman, L.; Stachoň, Z.

    2016-06-01

    Interactive 3D visualizations of spatial data are currently available and popular through various applications such as Google Earth, ArcScene, etc. Several scientific studies have focused on user performance with 3D visualization, but static perspective views are used as stimuli in most of the studies. The main objective of this paper is to try to identify potential differences in user performance with static perspective views and interactive visualizations. This research is an exploratory study. An experiment was designed as a between-subject study and a customized testing tool based on open web technologies was used for the experiment. The testing set consists of an initial questionnaire, a training task and four experimental tasks. Selection of the highest point and determination of visibility from the top of a mountain were used as the experimental tasks. Speed and accuracy of each task performance of participants were recorded. The movement and actions in the virtual environment were also recorded within the interactive variant. The results show that participants deal with the tasks faster when using static visualization. The average error rate was also higher in the static variant. The findings from this pilot study will be used for further testing, especially for formulating of hypotheses and designing of subsequent experiments.

  7. Automated 3D ultrasound elastography of the breast: a phantom validation study

    NASA Astrophysics Data System (ADS)

    Hendriks, Gijs A. G. M.; Holländer, Branislav; Menssen, Jan; Milkowski, Andy; Hansen, Hendrik H. G.; de Korte, Chris L.

    2016-04-01

    In breast cancer screening, the automated breast volume scanner (ABVS) was introduced as an alternative for mammography since the latter technique is less suitable for women with dense breasts. Although clinical studies show promising results, clinicians report two disadvantages: long acquisition times (>90 s) introducing breathing artefacts, and high recall rates due to detection of many small lesions of uncertain malignant potential. Technical improvements for faster image acquisition and better discrimination between benign and malignant lesions are thus required. Therefore, the aim of this study was to investigate if 3D ultrasound elastography using plane-wave imaging is feasible. Strain images of a breast elastography phantom were acquired by an ABVS-mimicking device that allowed axial and elevational movement of the attached transducer. Pre- and post-deformation volumes were acquired with different constant speeds (between 1.25 and 40.0 mm s-1) and by three protocols: Go-Go (pre- and post-volumes with identical start and end positions), Go-Return (similar to Go-Go with opposite scanning directions) and Control (pre- and post-volumes acquired per position, this protocol can be seen as reference). Afterwards, 2D and 3D cross-correlation and strain algorithms were applied to the acquired volumes and the results were compared. The Go-Go protocol was shown to be superior with better strain image quality (CNRe and SNRe) than Go-Return and to be similar as Control. This can be attributed to applying opposite mechanical forces to the phantom during the Go-Return protocol, leading to out-of-plane motion. This motion was partly compensated by using 3D cross-correlation. However, the quality was still inferior to Go-Go. Since these results were obtained in a phantom study with controlled deformations, the effect of possible uncontrolled in vivo tissue motion artefacts has to be addressed in future studies. In conclusion, it seems feasible to implement 3D ultrasound

  8. A Study of the dimensional accuracy obtained by low cost 3D printing for possible application in medicine

    NASA Astrophysics Data System (ADS)

    Kitsakis, K.; Alabey, P.; Kechagias, J.; Vaxevanidis, N.

    2016-11-01

    Low cost 3D printing' is a terminology that referred to the fused filament fabrication (FFF) technique, which constructs physical prototypes, by depositing material layer by layer using a thermal nozzle head. Nowadays, 3D printing is widely used in medical applications such as tissue engineering as well as supporting tool in diagnosis and treatment in Neurosurgery, Orthopedic and Dental-Cranio-Maxillo-Facial surgery. 3D CAD medical models are usually obtained by MRI or CT scans and then are sent to a 3D printer for physical model creation. The present paper is focused on a brief overview of benefits and limitations of 3D printing applications in the field of medicine as well as on a dimensional accuracy study of low-cost 3D printing technique.

  9. Does the mitral annulus shrink or enlarge during systole? A real-time 3D echocardiography study.

    PubMed

    Kwan, Jun; Jeon, Min-Jae; Kim, Dae-Hyeok; Park, Keum-Soo; Lee, Woo-Hyung

    2009-04-01

    This study was conducted to explore the geometrical changes of the mitral annulus during systole. The 3D shape of the mitral annulus was reconstructed in 13 normal subjects who had normal structure of the mitral apparatus using real-time 3D echocardiography (RT3DE) and 3D computer software. The two orthogonal (antero-posterior and commissure-commissure) dimensions, the areas (2D projected and 3D surface) and the non-planarity of the mitral annulus were estimated during early, mid and late systole. We demonstrated that the MA had a "saddle shape" appearance and it consistently enlarged mainly in the antero-posterior direction from early to late systole with lessening of its non-planarity, as was determined by 3D reconstruction using RT3DE and 3D computer software.

  10. 3D elastic full waveform inversion: case study from a land seismic survey

    NASA Astrophysics Data System (ADS)

    Kormann, Jean; Marti, David; Rodriguez, Juan-Esteban; Marzan, Ignacio; Ferrer, Miguel; Gutierrez, Natalia; Farres, Albert; Hanzich, Mauricio; de la Puente, Josep; Carbonell, Ramon

    2016-04-01

    Full Waveform Inversion (FWI) is one of the most advanced processing methods that is recently reaching a mature state after years of solving theoretical and technical issues such as the non-uniqueness of the solution and harnessing the huge computational power required by realistic scenarios. BSIT (Barcelona Subsurface Imaging Tools, www.bsc.es/bsit) includes a FWI algorithm that can tackle with very complex problems involving large datasets. We present here the application of this system to a 3D dataset acquired to constrain the shallow subsurface. This is where the wavefield is the most complicated, because most of the wavefield conversions takes place in the shallow region and also because the media is much more laterally heterogeneous. With this in mind, at least isotropic elastic approximation would be suitable as kernel engine for FWI. The current study explores the possibilities to apply elastic isotropic FWI using only the vertical component of the recorded seismograms. The survey covers an area of 500×500 m2, and consists in a receivers grid of 10 m×20 m combined with a 250 kg accelerated weight-drop as source on a displaced grid of 20 m×20 m. One of the main challenges in this case study is the costly 3D modeling that includes topography and substantial free surface effects. FWI is applied to a data subset (shooting lines 4 to 12), and is performed for 3 frequencies ranging from 15 to 25 Hz. The starting models are obtained from travel-time tomography and the all computation is run on 75 nodes of Mare Nostrum supercomputer during 3 days. The resulting models provide a higher resolution of the subsurface structures, and show a good correlation with the available borehole measurements. FWI allows to extend in a reliable way this 1D knowledge (borehole) to 3D.

  11. Spreading and Deposit Characteristics of a Rapid Dry Granular Avalanche Across 3D Topography: Experimental Study

    NASA Astrophysics Data System (ADS)

    Wang, Yu-Feng; Xu, Qiang; Cheng, Qian-Gong; Li, Yan; Luo, Zhong-Xu

    2016-11-01

    Aiming to understand the propagation and deposit behaviours of a granular avalanche along a 3D complex basal terrain, a new 3D experimental platform in 1/400 scale was developed according to the natural terrain of the Xiejiadianzi rock avalanche, with a series of laboratory experiments being conducted. Through the conduction of these tests, parameters, including the morphological evolution of sliding mass, run-outs and velocities of surficial particles, thickness contour and centre of final deposit, equivalent frictional coefficient, and energy dissipation, are documented and analysed, with the geomorphic control effect, material grain size effect, drop angle effect, and drop distance effect on rock avalanche mobility being discussed primarily. From the study, some interesting conclusions for a better understanding of rock avalanche along a 3D complex basal topography are reached. (1) For the granular avalanche tested in this study, great differences between the evolutions of the debris along the right and left branch valleys were observed, with an obvious geomorphic control effect on avalanche mobility presented. In addition, some other interesting features, including groove-like trough and superelevation, were also observed under the control of the topographic interferences. (2) The equivalent frictional coefficients of the granular avalanches tested here range from 0.48 to 0.57, which is lower than that reached with a set-up composed of an inclined chute and horizontal plate and higher than that reached using a set-up composed of only an inclined chute. And the higher the drop angle and fine particle content, the higher the equivalent frictional coefficient. The effect of drop distance on avalanche mobility is minor. (3) For a granular avalanche, momentum transfer plays an important role in the motion of mass, which can accelerate the mobility of the front part greatly through delivering the kinetic energy of the rear part to the front.

  12. 3D virtual human atria: A computational platform for studying clinical atrial fibrillation.

    PubMed

    Aslanidi, Oleg V; Colman, Michael A; Stott, Jonathan; Dobrzynski, Halina; Boyett, Mark R; Holden, Arun V; Zhang, Henggui

    2011-10-01

    Despite a vast amount of experimental and clinical data on the underlying ionic, cellular and tissue substrates, the mechanisms of common atrial arrhythmias (such as atrial fibrillation, AF) arising from the functional interactions at the whole atria level remain unclear. Computational modelling provides a quantitative framework for integrating such multi-scale data and understanding the arrhythmogenic behaviour that emerges from the collective spatio-temporal dynamics in all parts of the heart. In this study, we have developed a multi-scale hierarchy of biophysically detailed computational models for the human atria--the 3D virtual human atria. Primarily, diffusion tensor MRI reconstruction of the tissue geometry and fibre orientation in the human sinoatrial node (SAN) and surrounding atrial muscle was integrated into the 3D model of the whole atria dissected from the Visible Human dataset. The anatomical models were combined with the heterogeneous atrial action potential (AP) models, and used to simulate the AP conduction in the human atria under various conditions: SAN pacemaking and atrial activation in the normal rhythm, break-down of regular AP wave-fronts during rapid atrial pacing, and the genesis of multiple re-entrant wavelets characteristic of AF. Contributions of different properties of the tissue to mechanisms of the normal rhythm and arrhythmogenesis were investigated. Primarily, the simulations showed that tissue heterogeneity caused the break-down of the normal AP wave-fronts at rapid pacing rates, which initiated a pair of re-entrant spiral waves; and tissue anisotropy resulted in a further break-down of the spiral waves into multiple meandering wavelets characteristic of AF. The 3D virtual atria model itself was incorporated into the torso model to simulate the body surface ECG patterns in the normal and arrhythmic conditions. Therefore, a state-of-the-art computational platform has been developed, which can be used for studying multi

  13. Mechanisms of clay smear formation in 3D - a field study

    NASA Astrophysics Data System (ADS)

    Kettermann, Michael; Tronberens, Sebastian; Urai, Janos; Asmus, Sven

    2016-04-01

    Clay smears in sedimentary basins are important factors defining the sealing properties of faults. However, as clay smears are highly complex 3D structures, processes involved in the formation and deformation of clay smears are not well identified and understood. To enhance the prediction of sealing properties of clay smears extensive studies of these structures are necessary including the 3D information. We present extraordinary outcrop data from an open cast lignite mine (Hambach) in the Lower Rhine Embayment, Germany. The faults formed at a depth of 150 m, and have Shale Gouge Ratios between 0.1 and 0.3. Material in the fault zones is layered, with sheared sand, sheared clay and tectonically mixed sand-clay gouge. We studied the 3D thickness distribution of clay smear from a series of thin-spaced incremental cross-sections and several cross-sections in larger distances along the fault. Additionally, we excavated two large clay smear surfaces. Our observations show that clay smears are strongly affected by R- and R'-shears, mostly at the footwall side of our outcrops. These shears can locally cross and offset clay smears, forming holes. Thinnest parts of the clay smears are often located close to source layer cutoffs. Investigating the 3D thickness of the clay smears shows a heterogeneous distribution, rather than a continuous thinning of the smear with increasing distance to the source layers. We found two types of layered clay smears: one with continuous sheared sand between two clay smears providing vertical pathways for fluid flow, and one which consists of overlapping clay patches separated by sheared sand that provide a tortuous pathway across the clay smear. On smaller scale we identified grain-scale mixing as an important process for the formation of clay smears. Sand can be entrained into the clay smear by mixing from the surrounding host rock as well as due to intense shearing of sand lenses that were incorporated into the smear. This causes clay smears

  14. Image informatics for studying signal transduction in cells interacting with 3D matrices

    NASA Astrophysics Data System (ADS)

    Tzeranis, Dimitrios S.; Guo, Jin; Chen, Chengpin; Yannas, Ioannis V.; Wei, Xunbin; So, Peter T. C.

    2014-03-01

    Cells sense and respond to chemical stimuli on their environment via signal transduction pathways, complex networks of proteins whose interactions transmit chemical information. This work describes an implementation of image informatics, imaging-based methodologies for studying signal transduction networks. The methodology developed focuses on studying signal transduction networks in cells that interact with 3D matrices. It utilizes shRNA-based knock down of network components, 3D high-content imaging of cells inside the matrix by spectral multi-photon microscopy, and single-cell quantification using features that describe both cell morphology and cell-matrix adhesion pattern. The methodology is applied in a pilot study of TGFβ signaling via the SMAD pathway in fibroblasts cultured inside porous collagen-GAG scaffolds, biomaterials similar to the ones used clinically to induce skin regeneration. Preliminary results suggest that knocking down all rSMAD components affects fibroblast response to TGFβ1 and TGFβ3 isoforms in different ways, and suggest a potential role for SMAD1 and SMAD5 in regulating TGFβ isoform response. These preliminary results need to be verified with proteomic results that can provide solid evidence about the particular role of individual components of the SMAD pathway.

  15. 3-D LTCC microfluidic device as a tool for studying nanoprecipitation

    NASA Astrophysics Data System (ADS)

    Schianti, J. N.; Cerize, N. P. N.; Oliveira, A. M.; Derenzo, S.; Góngora-Rubio, M. R.

    2013-03-01

    Nanoparticles have been used to improve the properties of many cosmetic products, mainly the sunscreens materials using nanoencapsulation or nanosuspensions, improving the contact with active molecules, enhancing the sun protection effect and facilitating formulations in industrial products. Microfluidic devices offer an important possibility in producing nanoparticles in a simple way, in one step bottom up technique, continuum process with low polidispersivity, low consumption of reagents and additives. In this work, we microfabricated a 3-D LTCC microfluidic device to study the nanoprecipitation of Benzophenone-3, used as a sunscreen in pharmaceutical products. It was observed that some parameters influence the particle size related to the total fluid flow on device, the ratio between phases, and the Benzophenone-3 initial concentration. The influence of applied voltages on particle sizes was tested also. For the processing, a high voltage was applied in a Kovar tube inserted in the 3D device. The use of microfluidic device resulted in particles with 100 up to 800 nm of size, with polispersivity index below 0.3 and offering an interesting way to obtain nanoparticles. These studies are still ongoing, but early results indicate the possibility of obtaining B-3 nanostructured material.

  16. An experimental and numerical study of 3-D braided structural textile composites

    SciTech Connect

    Abusafieh, A.; Kalidindi, S.R.; Franco, E.

    1994-12-31

    It has been reported in literature that isostrain models (also known as Fabric Geometry Models) provide good predictions of the elastic moduli of three-dimensional textile composites. This study reports a critical evaluation of the accuracy of the isostrain models by comparing the predictions against experimental measurements as well as finite element simulations of representative unit cells of the 3-D braided composites, over a range of braid angles and volume fractions. The accuracy of the isostrain model is found to be highly sensitive to the braid angles and the fraction of lay-in axial fibers in the composite system. Good correlations between isostrain model predictions of elastic moduli and measurements were observed when the loading direction is oriented along one of the fiber directions and is significantly away from the other fiber systems in the unit cell. In other situations, however, the isostrain model predictions were in significant errors. This study also reports on the influence of various modeling parameters in the development of finite element models for the simulation of the 3-D textile composite unit cells.

  17. Combined 3D-QSAR modeling and molecular docking study on azacycles CCR5 antagonists

    NASA Astrophysics Data System (ADS)

    Ji, Yongjun; Shu, Mao; Lin, Yong; Wang, Yuanqiang; Wang, Rui; Hu, Yong; Lin, Zhihua

    2013-08-01

    The beta chemokine receptor 5 (CCR5) is an attractive target for pharmaceutical industry in the HIV-1, inflammation and cancer therapeutic areas. In this study, we have developed quantitative structure activity relationship (QSAR) models for a series of 41 azacycles CCR5 antagonists using comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA), and Topomer CoMFA methods. The cross-validated coefficient q2 values of 3D-QASR (CoMFA, CoMSIA, and Topomer CoMFA) methods were 0.630, 0.758, and 0.852, respectively, the non-cross-validated R2 values were 0.979, 0.978, and 0.990, respectively. Docking studies were also employed to determine the most probable binding mode. 3D contour maps and docking results suggested that bulky groups and electron-withdrawing groups on the core part would decrease antiviral activity. Furthermore, docking results indicated that H-bonds and π bonds were favorable for antiviral activities. Finally, a set of novel derivatives with predicted activities were designed.

  18. Study of 3D printing method for GRIN micro-optics devices

    NASA Astrophysics Data System (ADS)

    Wang, P. J.; Yeh, J. A.; Hsu, W. Y.; Cheng, Y. C.; Lee, W.; Wu, N. H.; Wu, C. Y.

    2016-03-01

    Conventional optical elements are based on either refractive or reflective optics theory to fulfill the design specifications via optics performance data. In refractive optical lenses, the refractive index of materials and radius of curvature of element surfaces determine the optical power and wavefront aberrations so that optical performance can be further optimized iteratively. Although gradient index (GRIN) phenomenon in optical materials is well studied for more than a half century, the optics theory in lens design via GRIN materials is still yet to be comprehensively investigated before realistic GRIN lenses are manufactured. In this paper, 3D printing method for manufacture of micro-optics devices with special features has been studied based on methods reported in the literatures. Due to the additive nature of the method, GRIN lenses in micro-optics devices seem to be readily achievable if a design methodology is available. First, derivation of ray-tracing formulae is introduced for all possible structures in GRIN lenses. Optics simulation program is employed for characterization of GRIN lenses with performance data given by aberration coefficients in Zernike polynomial. Finally, a proposed structure of 3D printing machine is described with conceptual illustration.

  19. 3D Numerical Study of the Shear Rheology of a Semi-dilute Viscoelastic Suspension

    NASA Astrophysics Data System (ADS)

    Yang, Mengfei; Krishnan, Sreenath; Shaqfeh, Eric

    2016-11-01

    The stress in suspensions of rigid particles in polymer solutions is of considerable interest in applications such as manufacturing processes and fracturing technologies. Deriving an analytic expression for the material functions of a viscoelastic suspension under shear is difficult due to the nonlinear particle-fluid and particle-particle interactions, and theoretical studies have been limited to dilute suspensions at low shear Weissenberg number (Wi) or low polymer concentrations. Previously, we performed 3D single-particle simulations and showed that the results agreed well with the existing theories in the appropriate parameter regimes. We found that suspensions in constant-viscosity elastic fluids shear-thicken over a range of Wi and their material properties plateau at higher Wi. However, discrepancies between simulation and existing experimental measurements for volume fractions as low as 2.5% suggested that interparticle hydrodynamic interactions could not be neglected. We now present 3D high fidelity numerical simulations of multiple spheres freely suspended in a sheared viscoelastic fluid using an immersed boundary framework to study the relationship between hydrodynamic interactions, particle structure formation, and the bulk rheology of viscoelastic suspensions. We observe that in a non-shear thinning elastic fluid, particles do not "chain", but their interactions induce additional polymer stresses in the fluid which contribute to a stronger particle effect than predicted in the dilute limit.

  20. 3D-QSAR and docking studies of pentacycloundecylamines at the sigma-1 (σ1) receptor.

    PubMed

    Geldenhuys, Werner J; Novotny, Nicholas; Malan, Sarel F; Van der Schyf, Cornelis J

    2013-03-15

    Pentacycloundecylamine (PCU) derived compounds have been shown to be promising lead structures for the development of novel drug candidates aimed at a variety of neurodegenerative and psychiatric diseases. Here we show for the first time a 3D quantitative structure-activity relationship (3D-QSAR) for a series of aza-PCU-derived compounds with activity at the sigma-1 (σ1) receptor. A comparative molecular field analysis (CoMFA) model was developed with a partial least squares cross validated (q(2)) regression value of 0.6, and a non-cross validated r(2) of 0.9. The CoMFA model was effective at predicting the sigma-1 activities of a test set with an r(2) >0.7. We also describe here the docking of the PCU-derived compounds into a homology model of the sigma-1 (σ1) receptor, which was developed to gain insight into binding of these cage compounds to the receptor. Based on docking studies we evaluated in a [(3)H]pentazocine binding assay an oxa-PCU, NGP1-01 (IC50=1.78μM) and its phenethyl derivative (IC50=1.54μM). Results from these studies can be used to develop new compounds with specific affinity for the sigma-1(σ1) receptor.

  1. The study of craniofacial growth patterns using 3D laser scanning and geometric morphometrics

    NASA Astrophysics Data System (ADS)

    Friess, Martin

    2006-02-01

    Throughout childhood, braincase and face grow at different rates and therefore exhibit variable proportions and positions relative to each other. Our understanding of the direction and magnitude of these growth patterns is crucial for many ergonomic applications and can be improved by advanced 3D morphometrics. The purpose of this study is to investigate this known growth allometry using 3D imaging techniques. The geometry of the head and face of 840 children, aged 2 to 19, was captured with a laser surface scanner and analyzed statistically. From each scan, 18 landmarks were extracted and registered using General Procrustes Analysis (GPA). GPA eliminates unwanted variation due to position, orientation and scale by applying a least-squares superimposition algorithm to individual landmark configurations. This approach provides the necessary normalization for the study of differences in size, shape, and their interaction (allometry). The results show that throughout adolescence, boys and girls follow a different growth trajectory, leading to marked differences not only in size but also in shape, most notably in relative proportions of the braincase. These differences can be observed during early childhood, but become most noticeable after the age of 13 years, when craniofacial growth in girls slows down significantly, whereas growth in boys continues for at least 3 more years.

  2. Numerical 3D Hydrodynamics Study of Gravitational Instabilities in a Circumbinary Disk

    NASA Astrophysics Data System (ADS)

    Desai, Karna Mahadev; Steiman-Cameron, Thomas Y.; Michael, Scott; Cai, Kai; Durisen, Richard H.

    2016-01-01

    We present a 3D hydrodynamical study of gravitational instabilities (GIs) in a circumbinary protoplanetary disk around a Solar mass star and a brown dwarf companion (0.02 M⊙). GIs can play an important, and at times dominant, role in driving the structural evolution of protoplanetary disks. The reported simulations were performed employing CHYMERA, a radiative 3D hydrodynamics code developed by the Indiana University Hydrodynamics Group. The simulations include disk self-gravity and radiative cooling governed by realistic dust opacities. We examine the role of GIs in modulating the thermodynamic state of the disks, and determine the strengths of GI-induced density waves, non-axisymmetric density structures, radial mass transport, and gravitational torques. The principal goal of this study is to determine how the presence of the companion affects the nature and strength of GIs. Results are compared with a parallel simulation of a protoplanetary disk without the presence of the brown dwarf binary companion. We detect no fragmentation in either disk. A persistent vortex forms in the inner region of both disks. The vortex seems to be stabilized by the presence of the binary companion.

  3. Test Problems for Reactive Flow HE Model in the ALE3D Code and Limited Sensitivity Study

    SciTech Connect

    Gerassimenko, M.

    2000-03-01

    We document quick running test problems for a reactive flow model of HE initiation incorporated into ALE3D. A quarter percent change in projectile velocity changes the outcome from detonation to HE burn that dies down. We study the sensitivity of calculated HE behavior to several parameters of practical interest where modeling HE initiation with ALE3D.

  4. Human Microtumors Generated in 3D: Novel Tools for Integrated In Situ Studies of Cancer Immunotherapies.

    PubMed

    Hambach, Lothar; Buser, Andreas; Vermeij, Marcel; Pouw, Nadine; van der Kwast, Theo; Goulmy, Els

    2016-01-01

    Cellular immunotherapy targeting human tumor antigens is a promising strategy to treat solid tumors. Yet clinical results of cellular immunotherapy are disappointing. Moreover, the currently available in vitro human tumor models are not designed to study the optimization of T-cell therapies of solid tumors. Here, we describe a novel assay for multiparametric in situ analysis of therapeutic effects on individual human three-dimensional (3D) tumors. In this assay, tumors of several millimeter diameter are generated from human cancer cell lines of different tumor entities in a collagen type I microenvironment. A newly developed approach for efficient morphological analysis reveals that these in vitro tumors resemble many characteristics of the corresponding clinical cancers such as histological features, immunohistochemical staining patterns, distinct tumor growth compartments and heterogeneous protein expression. To assess the response to therapy with tumor antigen specific T-cells, standardized protocols are described to determine T-cell infiltration and tumor destruction by monitoring soluble factors and tumor growth. Human tumors engineered in 3D collagen scaffolds are excellent in vitro surrogates for avascular tumor stages allowing integrated analyses of the antitumor efficacy of cancer specific immunotherapy in situ.

  5. VA-086 methacrylate gelatine photopolymerizable hydrogels: A parametric study for highly biocompatible 3D cell embedding.

    PubMed

    Occhetta, Paola; Visone, Roberta; Russo, Laura; Cipolla, Laura; Moretti, Matteo; Rasponi, Marco

    2015-06-01

    The ability to replicate in vitro the native extracellular matrix (ECM) features and to control the three-dimensional (3D) cell organization plays a fundamental role in obtaining functional engineered bioconstructs. In tissue engineering (TE) applications, hydrogels have been successfully implied as biomatrices for 3D cell embedding, exhibiting high similarities to the natural ECM and holding easily tunable mechanical properties. In the present study, we characterized a promising photocrosslinking process to generate cell-laden methacrylate gelatin (GelMA) hydrogels in the presence of VA-086 photoinitiator using a ultraviolet LED source. We investigated the influence of prepolymer concentration and light irradiance on mechanical and biomimetic properties of resulting hydrogels. In details, the increasing of gelatin concentration resulted in enhanced rheological properties and shorter polymerization time. We then defined and validated a reliable photopolymerization protocol for cell embedding (1.5% VA-086, LED 2 mW/cm2) within GelMA hydrogels, which demonstrated to support bone marrow stromal cells viability when cultured up to 7 days. Moreover, we showed how different mechanical properties, derived from different crosslinking parameters, strongly influence cell behavior. In conclusion, this protocol can be considered a versatile tool to obtain biocompatible cell-laden hydrogels with properties easily adaptable for different TE applications.

  6. Numerical and experimental study of gas flows in 2D and 3D microchannels

    NASA Astrophysics Data System (ADS)

    Guo, Xiaohui; Huang, Chihyung; Alexeenko, Alina; Sullivan, John

    2008-02-01

    In the experiments conducted at Purdue, the air flow in rectangular cross-section microchannels was investigated using pressure sensitive paint. The high resolution pressure measurements were obtained for inlet-to-outlet pressure ratios from 1.76 to 20 with the outlet Knudsen numbers in the range from 0.003 to 0.4 based on the hydraulic diameter of 151.7 µm and the length-to-height ratio of about 50. In the slip flow regime, the air flow was simulated by the 2D and 3D Navier-Stokes equations with no-slip and slip boundary conditions. For various pressure ratios, the entrance flow development, compressibility and rarefaction effects were observed in both experiments and numerical simulations. It was found that the accurate modeling of gas flows in finite-length channels requires the inlet and outlet reservoirs to be included in computations. Effects of entrance geometry on the friction factor were studied for 3D cases. In both experiments and numerical modeling, significant pressure drop was found starting at the inlet chamber. The numerical modeling also predicted an apparent temperature drop at the channel exit.

  7. A biofidelic 3D culture model to study the development of brain cellular systems.

    PubMed

    Ren, M; Du, C; Herrero Acero, E; Tang-Schomer, M D; Özkucur, N

    2016-04-26

    Little is known about how cells assemble as systems during corticogenesis to generate collective functions. We built a neurobiology platform that consists of fetal rat cerebral cortical cells grown within 3D silk scaffolds (SF). Ivermectin (Ivm), a glycine receptor (GLR) agonist, was used to modulate cell resting membrane potential (Vmem) according to methods described in a previous work that implicated Ivm in the arrangement and connectivity of cortical cell assemblies. The cells developed into distinct populations of neuroglial stem/progenitor cells, mature neurons or epithelial-mesenchymal cells. Importantly, the synchronized electrical activity in the newly developed cortical assemblies could be recorded as local field potential (LFP) measurements. This study therefore describes the first example of the development of a biologically relevant cortical plate assembly outside of the body. This model provides i) a preclinical basis for engineering cerebral cortex tissue autografts and ii) a biofidelic 3D culture model for investigating biologically relevant processes during the functional development of cerebral cortical cellular systems.

  8. Reliability and validity of the tritrac-R3D accelerometer during backpacking: a case study.

    PubMed

    DeVoe, D; Dalleck, L

    2001-08-01

    This study investigated the utility of the Tritrac-R3D accelerometer as a reliable and valid instrument in the quantification of physical activity while backpacking in the field and to evaluate heart-rate responses and oxygen consumption to assess the feasibility of using the Tritrac-R3D to estimate caloric expenditure. Two 7-day backpacking expeditions were conducted in two consecutive years by a single subject at Grand Canyon National Park, Arizona. The average hiking heart rate ranged front 60% to 77% HRmax during the expeditions. The average rate of estimated caloric cost ranged from 6.8 to 11.7 kcals x min.(-1) (equivalent to 408 to 702 kcals x hr.(-1)), indicating a relatively moderate to high level of exertion. The Tritrac had adequate consistency and reliability in the field between the two expeditions in recorded activity counts. The Tritrac underestimated caloric expenditure during backpacking with changes in terrain, and hiking speed contributed to even greater disparity in accuracy.

  9. RF study and 3-D simulations of a side-coupling thermionic RF-gun

    NASA Astrophysics Data System (ADS)

    Rimjaem, S.; Kusoljariyakul, K.; Thongbai, C.

    2014-02-01

    A thermionic RF-gun for generating ultra-short electron bunches was optimized, developed and used as a source at a linac-based THz radiation research laboratory of the Plasma and Beam Physics Research Facility, Chiang Mai University, Thailand. The RF-gun is a π/2-mode standing wave structure, which consists of two S-band accelerating cells and a side-coupling cavity. The 2856 MHz RF wave is supplied from an S-band klystron to the gun through the waveguide input-port at the cylindrical wall of the second cell. A fraction of the RF power is coupled from the second cell to the first one via a side-coupling cavity. Both the waveguide input-port and the side-coupling cavity lead to an asymmetric geometry of the gun. RF properties and electromagnetic field distributions inside the RF-gun were studied and numerically simulated by using computer codes SUPERFISH 7.19 and CST Microwave Studio 2012©. RF characterizations and tunings of the RF-gun were performed to ensure the reliability of the gun operation. The results from 3D simulations and measurements are compared and discussed in this paper. The influence of asymmetric field distributions inside the RF-gun on the electron beam properties was investigated via 3D beam dynamics simulations. A change in the coupling-plane of the side-coupling cavity is suggested to improve the gun performance.

  10. Shear Behavior of 3D Woven Hollow Integrated Sandwich Composites: Experimental, Theoretical and Numerical Study

    NASA Astrophysics Data System (ADS)

    Zhou, Guangming; Liu, Chang; Cai, Deng'an; Li, Wenlong; Wang, Xiaopei

    2016-11-01

    An experimental, theoretical and numerical investigation on the shear behavior of 3D woven hollow integrated sandwich composites was presented in this paper. The microstructure of the composites was studied, then the shear modulus and load-deflection curves were obtained by double lap shear tests on the specimens in two principal directions of the sandwich panels, called warp and weft. The experimental results showed that the shear modulus of the warp was higher than that of the weft and the failure occurred in the roots of piles. A finite element model was established to predict the shear behavior of the composites. The simulated results agreed well with the experimental data. Simultaneously, a theoretical method was developed to predict the shear modulus. By comparing with the experimental data, the accuracy of the theoretical method was verified. The influence of structural parameters on shear modulus was also discussed. The higher yarn number, yarn density and dip angle of the piles could all improve the shear modulus of 3D woven hollow integrated sandwich composites at different levels, while the increasing height would decrease the shear modulus.

  11. A small animal image guided irradiation system study using 3D dosimeters

    NASA Astrophysics Data System (ADS)

    Qian, Xin; Admovics, John; Wuu, Cheng-Shie

    2015-01-01

    In a high resolution image-guided small animal irradiation platform, a cone beam computed tomography (CBCT) is integrated with an irradiation unit for precise targeting. Precise quality assurance is essential for both imaging and irradiation components. The conventional commissioning techniques with films face major challenges due to alignment uncertainty and labour intensive film preparation and scanning. In addition, due to the novel design of this platform the mouse stage rotation for CBCT imaging is perpendicular to the gantry rotation for irradiation. Because these two rotations are associated with different mechanical systems, discrepancy between rotation isocenters exists. In order to deliver x-ray precisely, it is essential to verify coincidence of the imaging and the irradiation isocenters. A 3D PRESAGE dosimeter can provide an excellent tool for checking dosimetry and verifying coincidence of irradiation and imaging coordinates in one system. Dosimetric measurements were performed to obtain beam profiles and percent depth dose (PDD). Isocentricity and coincidence of the mouse stage and gantry rotations were evaluated with starshots acquired using PRESAGE dosimeters. A single PRESAGE dosimeter can provide 3 -D information in both geometric and dosimetric uncertainty, which is crucial for translational studies.

  12. A comparative study of bio-inspired protective scales using 3D printing and mechanical testing.

    PubMed

    Martini, Roberto; Balit, Yanis; Barthelat, Francois

    2017-03-16

    Flexible natural armors from fish, alligators or armadillo are attracting an increasing amount of attention for their unique combinations of hardness, flexibility and light weight. The extreme contrast of stiffness between hard scales and surrounding soft tissues gives rise to unusual and attractive mechanisms, which now serve as models for the design of bio-inspired armors. Despite this growing interest, there is little guideline for the choice of materials, optimum thickness, size, shape and arrangement for the protective scales. In this work, we explore how the geometry and arrangement of hard scales can be tailored to promote scale-scale interactions. We use 3D printing to fabricate arrays of scales with increasingly complex geometries and arrangements, from simple squares with no overlap to complex ganoid-scales with overlaps and interlocking features. We performed puncture tests and flexural tests on each of the 3D printed materials, and we report the puncture resistance - compliance characteristics of each design on an Ashby chart. The interactions between the scales can significantly increase the resistance to puncture, and these interactions can be maximized by tuning the geometry and arrangement of the scales. Interestingly, the designs that offer the best combinations of puncture resistance and flexural compliance are similar to the geometry and arrangement of natural teleost and ganoid scales, which suggests that natural evolution has shaped these systems to maximize flexible protection. This study yields new insights into the mechanisms of natural dermal armor, and also suggests new designs for personal protective systems.

  13. Computational Study of 3-D Hot-Spot Initiation in Shocked Insensitive High-Explosive

    NASA Astrophysics Data System (ADS)

    Najjar, F. M.; Howard, W. M.; Fried, L. E.

    2011-06-01

    High explosive shock sensitivity is controlled by a combination of mechanical response, thermal properties, and chemical properties. The interplay of these physical phenomena in realistic condensed energetic materials is currently lacking. A multiscale computational framework is developed investigating hot spot (void) ignition in a single crystal of an insensitive HE, TATB. Atomistic MD simulations are performed to provide the key chemical reactions and these reaction rates are used in 3-D multiphysics simulations. The multiphysics code, ALE3D, is linked to the chemistry software, Cheetah, and a three-way coupled approach is pursued including hydrodynamics, thermal and chemical analyses. A single spherical air bubble is embedded in the insensitive HE and its collapse due to shock initiation is evolved numerically in time; while the ignition processes due chemical reactions are studied. Our current predictions showcase several interesting features regarding hot spot dynamics including the formation of a ``secondary'' jet. Results obtained with hydro-thermo-chemical processes leading to ignition growth will be discussed for various pore sizes and different shock pressures. LLNL-ABS-471438. This work performed under the auspices of the U.S. Department of Energy by LLNL under Contract DE-AC52-07NA27344.

  14. A biofidelic 3D culture model to study the development of brain cellular systems

    PubMed Central

    Ren, M.; Du, C.; Herrero Acero, E.; Tang-Schomer, M. D.; Özkucur, N.

    2016-01-01

    Little is known about how cells assemble as systems during corticogenesis to generate collective functions. We built a neurobiology platform that consists of fetal rat cerebral cortical cells grown within 3D silk scaffolds (SF). Ivermectin (Ivm), a glycine receptor (GLR) agonist, was used to modulate cell resting membrane potential (Vmem) according to methods described in a previous work that implicated Ivm in the arrangement and connectivity of cortical cell assemblies. The cells developed into distinct populations of neuroglial stem/progenitor cells, mature neurons or epithelial-mesenchymal cells. Importantly, the synchronized electrical activity in the newly developed cortical assemblies could be recorded as local field potential (LFP) measurements. This study therefore describes the first example of the development of a biologically relevant cortical plate assembly outside of the body. This model provides i) a preclinical basis for engineering cerebral cortex tissue autografts and ii) a biofidelic 3D culture model for investigating biologically relevant processes during the functional development of cerebral cortical cellular systems. PMID:27112667

  15. A 3D numerical study of antimicrobial persistence in heterogeneous multi-species biofilms.

    PubMed

    Zhao, Jia; Shen, Ya; Haapasalo, Markus; Wang, Zhejun; Wang, Qi

    2016-03-07

    We develop a 3D hydrodynamic model to investigate the mechanism of antimicrobial persistence in a multi-species oral biofilm and its recovery after being treated by bisbiguanide chlorhexidine gluconate (CHX). In addition to the hydrodynamic transport in the spatially heterogeneous biofilm, the model also includes mechanisms of solvent-biomass interaction, bacterial phenotype conversion, and bacteria-drug interaction. A numerical solver for the model is developed using a second order numerical scheme in 3D space and time and implemented on GPUs for high-performance computing. The model is calibrated against a set of experimental data obtained using confocal laser scan microscopy (CLSM) on multi-species oral biofilms, where a quantitative agreement is reached. Our numerical results reveal that quorum sensing molecules and growth factors in this model are instrumental in biofilm formation and recovery after the antimicrobial treatment. In particular, we show that (i) young biofilms are more susceptible to the antimicrobial treatment than the mature ones, (ii) this phenomenon is strongly correlated with volume fractions of the persister and EPS in the biofilm being treated. This suggests that antimicrobial treatment should be best administered to biofilms earlier before they mature to produce a thick protective EPS layer. In addition, the numerical study also indicates that an antimicrobial effect can be achieved should a proper mechanism be devised to minimize the conversion of susceptible bacteria to persisters during and even after the treatment.

  16. Liner Optimization Studies Using the Ducted Fan Noise Prediction Code TBIEM3D

    NASA Technical Reports Server (NTRS)

    Dunn, M. H.; Farassat, F.

    1998-01-01

    In this paper we demonstrate the usefulness of the ducted fan noise prediction code TBIEM3D as a liner optimization design tool. Boundary conditions on the interior duct wall allow for hard walls or a locally reacting liner with axially segmented, circumferentially uniform impedance. Two liner optimization studies are considered in which farfield noise attenuation due to the presence of a liner is maximized by adjusting the liner impedance. In the first example, the dependence of optimal liner impedance on frequency and liner length is examined. Results show that both the optimal impedance and attenuation levels are significantly influenced by liner length and frequency. In the second example, TBIEM3D is used to compare radiated sound pressure levels between optimal and non-optimal liner cases at conditions designed to simulate take-off. It is shown that significant noise reduction is achieved for most of the sound field by selecting the optimal or near optimal liner impedance. Our results also indicate that there is relatively large region of the impedance plane over which optimal or near optimal liner behavior is attainable. This is an important conclusion for the designer since there are variations in liner characteristics due to manufacturing imprecisions.

  17. Synthesis, in vitro antitubercular activity and 3D-QSAR study of 1,4-dihydropyridines.

    PubMed

    Manvar, Atul T; Pissurlenkar, Raghuvir R S; Virsodia, Vijay R; Upadhyay, Kuldip D; Manvar, Dinesh R; Mishra, Arun K; Acharya, Hrishikesh D; Parecha, Alpesh R; Dholakia, Chintan D; Shah, Anamik K; Coutinho, Evans C

    2010-05-01

    In continuation of our research program on new antitubercular agents, this article is a report of the synthesis of 97 various symmetrical, unsymmetrical, and N-substituted 1,4-dihydropyridines. The synthesized molecules were tested for their activity against M. tuberculosis H (37)Rv strain with rifampin as the standard drug. The percentage inhibition was found in the range 3-93%. In an effort to understand the relationship between structure and activity, 3D-QSAR studies were also carried out on a subset that is representative of the molecules synthesized. For the generation of the QSAR models, a training set of 35 diverse molecules representing the synthesized molecules was utilized. The molecules were aligned using the atom-fit technique. The CoMFA and CoMSIA models generated on the molecules aligned by the atom-fit method show a correlation coefficient (r (2)) of 0.98 and 0.95 with cross-validated r (2)(q (2)) of 0.56 and 0.62, respectively. The 3D-QSAR models were externally validated against a test set of 19 molecules (aligned previously with the training set) for which the predictive r(2)(r(r)(pred)) is recorded as 0.74 and 0.69 for the CoMFA and CoMSIA models, respectively. The models were checked for chance correlation through y-scrambling. The QSAR models revealed the importance of the conformational flexibility of the substituents in antitubercular activity.

  18. Non-Newtonian Fluids Spreading with Surface Tension Effect: 3D Numerical Analysis Using FEM and Experimental Study

    NASA Astrophysics Data System (ADS)

    Hu, Bin; Kieweg, Sarah

    2010-11-01

    Gravity-driven thin film flow down an incline is studied for optimal design of polymeric drug delivery vehicles, such as anti-HIV topical microbicides. We develop a 3D FEM model using non-Newtonian mechanics to model the flow of gels in response to gravity, surface tension and shear-thinning. Constant volume setup is applied within the lubrication approximation scope. The lengthwise profiles of the 3D model agree with our previous 2D finite difference model, while the transverse contact line patterns of the 3D model are compared to the experiments. With incorporation of surface tension, capillary ridges are observed at the leading front in both 2D and 3D models. Previously published studies show that capillary ridge can amplify the fingering instabilities in transverse direction. Sensitivity studies (2D & 3D) and experiments are carried out to describe the influence of surface tension and shear-thinning on capillary ridge and fingering instabilities.

  19. Procedural 3d Modelling for Traditional Settlements. The Case Study of Central Zagori

    NASA Astrophysics Data System (ADS)

    Kitsakis, D.; Tsiliakou, E.; Labropoulos, T.; Dimopoulou, E.

    2017-02-01

    Over the last decades 3D modelling has been a fast growing field in Geographic Information Science, extensively applied in various domains including reconstruction and visualization of cultural heritage, especially monuments and traditional settlements. Technological advances in computer graphics, allow for modelling of complex 3D objects achieving high precision and accuracy. Procedural modelling is an effective tool and a relatively novel method, based on algorithmic modelling concept. It is utilized for the generation of accurate 3D models and composite facade textures from sets of rules which are called Computer Generated Architecture grammars (CGA grammars), defining the objects' detailed geometry, rather than altering or editing the model manually. In this paper, procedural modelling tools have been exploited to generate the 3D model of a traditional settlement in the region of Central Zagori in Greece. The detailed geometries of 3D models derived from the application of shape grammars on selected footprints, and the process resulted in a final 3D model, optimally describing the built environment of Central Zagori, in three levels of Detail (LoD). The final 3D scene was exported and published as 3D web-scene which can be viewed with 3D CityEngine viewer, giving a walkthrough the whole model, same as in virtual reality or game environments. This research work addresses issues regarding textures' precision, LoD for 3D objects and interactive visualization within one 3D scene, as well as the effectiveness of large scale modelling, along with the benefits and drawbacks that derive from procedural modelling techniques in the field of cultural heritage and more specifically on 3D modelling of traditional settlements.

  20. 3D-2D ultrasound feature-based registration for navigated prostate biopsy: a feasibility study.

    PubMed

    Selmi, Sonia Y; Promayon, Emmanuel; Troccaz, Jocelyne

    2016-08-01

    The aim of this paper is to describe a 3D-2D ultrasound feature-based registration method for navigated prostate biopsy and its first results obtained on patient data. A system combining a low-cost tracking system and a 3D-2D registration algorithm was designed. The proposed 3D-2D registration method combines geometric and image-based distances. After extracting features from ultrasound images, 3D and 2D features within a defined distance are matched using an intensity-based function. The results are encouraging and show acceptable errors with simulated transforms applied on ultrasound volumes from real patients.

  1. Are There Side Effects to Watching 3D Movies? A Prospective Crossover Observational Study on Visually Induced Motion Sickness

    PubMed Central

    Solimini, Angelo G.

    2013-01-01

    Background The increasing popularity of commercial movies showing three dimensional (3D) images has raised concern about possible adverse side effects on viewers. Methods and Findings A prospective carryover observational study was designed to assess the effect of exposure (3D vs. 2D movie views) on self reported symptoms of visually induced motion sickness. The standardized Simulator Sickness Questionnaire (SSQ) was self administered on a convenience sample of 497 healthy adult volunteers before and after the vision of 2D and 3D movies. Viewers reporting some sickness (SSQ total score>15) were 54.8% of the total sample after the 3D movie compared to 14.1% of total sample after the 2D movie. Symptom intensity was 8.8 times higher than baseline after exposure to 3D movie (compared to the increase of 2 times the baseline after the 2D movie). Multivariate modeling of visually induced motion sickness as response variables pointed out the significant effects of exposure to 3D movie, history of car sickness and headache, after adjusting for gender, age, self reported anxiety level, attention to the movie and show time. Conclusions Seeing 3D movies can increase rating of symptoms of nausea, oculomotor and disorientation, especially in women with susceptible visual-vestibular system. Confirmatory studies which include examination of clinical signs on viewers are needed to pursue a conclusive evidence on the 3D vision effects on spectators. PMID:23418530

  2. Exploring the surface reactivity of 3d metal endofullerenes: a density-functional theory study.

    PubMed

    Estrada-Salas, Rubén E; Valladares, Ariel A

    2009-09-24

    Changes in the preferential sites of electrophilic, nucleophilic, and radical attacks on the pristine C60 surface with endohedral doping using 3d transition metal atoms were studied via two useful reactivity indices, namely the Fukui functions and the molecular electrostatic potential. Both of these were calculated at the density functional BPW91 level of theory with the DNP basis set. Our results clearly show changes in the preferential reactivity sites on the fullerene surface when it is doped with Mn, Fe, Co, or Ni atoms, whereas there are no significant changes in the preferential reactivity sites on the C60 surface upon endohedral doping with Cu and Zn atoms. Electron affinities (EA), ionization potentials (IP), and HOMO-LUMO gaps (Eg) were also calculated to complete the study of the endofullerene's surface reactivity. These findings provide insight into endofullerene functionalization, an important issue in their application.

  3. 3D Human Motion Editing and Synthesis: A Survey

    PubMed Central

    Wang, Xin; Chen, Qiudi; Wang, Wanliang

    2014-01-01

    The ways to compute the kinematics and dynamic quantities of human bodies in motion have been studied in many biomedical papers. This paper presents a comprehensive survey of 3D human motion editing and synthesis techniques. Firstly, four types of methods for 3D human motion synthesis are introduced and compared. Secondly, motion capture data representation, motion editing, and motion synthesis are reviewed successively. Finally, future research directions are suggested. PMID:25045395

  4. In vivo kinematics of the talocrural and subtalar joints with functional ankle instability during weight-bearing ankle internal rotation: a pilot study.

    PubMed

    Kobayashi, Takumi; No, Yumi; Yoneta, Kei; Sadakiyo, Masashi; Gamada, Kazuyoshi

    2013-06-01

    Functional ankle instability (FAI) may involve abnormal kinematics. However, reliable quantitative data for kinematics of FAI have not been reported. The objective of this study was to determine if the abnormal kinematics exist in the talocrural and subtalar joints in patients with FAI. Five male subjects with unilateral FAI (a mean age of 33.4 ± 13.2 years) were enrolled. All subjects were examined with stress radiography and found to have no mechanical ankle instability (MAI). Lateral radiography at weight-bearing ankle internal rotation of 0° and 20° was taken with the ankle at 30° dorsiflexion and 30° plantar flexion. Patients underwent computed tomography scan at 1.0 mm slice pitch spanning distal one third of the lower leg and the distal end of the calcaneus. Three-dimensional (3D) kinematics of the talocrural and subtalar joints as well as the ankle joint complex (AJC) were determined using a 3D-to-2D registration technique using a 3D-to-2D registration technique with 3D bone models and plain radiography. FAI joints in ankle dorsiflexion demonstrated significantly greater subtalar internal rotation from 0° to 20° internal rotation. No statistical differences in plantar flexion were detected in talocrural, subtalar or ankle joint complex kinematics between the FAI and contralateral healthy joints. During ankle internal rotation in dorsiflexion, FAI joints demonstrated greater subtalar internal rotation. The FAI joints without mechanical instability presented abnormal kinematics. This suggests that abnormal kinematics of the FAI joints may contribute to chronic instability. FAI joints may involve unrecognized abnormal subtalar kinematics during internal rotation in ankle dorsiflexion which may contribute to chronic instability and frequent feelings of instability.

  5. Feasibility of a 3D human airway epithelial model to study respiratory absorption.

    PubMed

    Reus, Astrid A; Maas, Wilfred J M; Jansen, Harm T; Constant, Samuel; Staal, Yvonne C M; van Triel, Jos J; Kuper, C Frieke

    2014-03-01

    The respiratory route is an important portal for human exposure to a large variety of substances. Consequently, there is an urgent need for realistic in vitro strategies for evaluation of the absorption of airborne substances with regard to safety and efficacy assessment. The present study investigated feasibility of a 3D human airway epithelial model to study respiratory absorption, in particular to differentiate between low and high absorption of substances. Bronchial epithelial models (MucilAir™), cultured at the air-liquid interface, were exposed to eight radiolabeled model substances via the apical epithelial surface. Absorption was evaluated by measuring radioactivity in the apical compartment, the epithelial cells and the basolateral culture medium. Antipyrine, caffeine, naproxen and propranolol were highly transported across the epithelial cell layer (>5%), whereas atenolol, mannitol, PEG-400 and insulin were limitedly transported (<5%). Results indicate that the 3D human airway epithelial model used in this study is able to differentiate between substances with low and high absorption. The intra-experimental reproducibility of the results was considered adequate based on an average coefficient of variation (CV) of 15%. The inter-experimental reproducibility of highly absorbed compounds was in a similar range (CV of 15%), but this value was considerably higher for those compounds that were limitedly absorbed. No statistical significant differences between different donors and experiments were observed. The present study provides a simple method transposable in any lab, which can be used to rank the absorption of chemicals and pharmaceuticals, and is ready for further validation with respect to reproducibility and capacity of the method to predict respiratory transport in humans.

  6. Comparison of quasi-static and dynamic squats: a three-dimensional kinematic, kinetic and electromyographic study of the lower limbs.

    PubMed

    Clément, Julien; Hagemeister, Nicola; Aissaoui, Rachid; de Guise, Jacques A

    2014-01-01

    Numerous studies have described 3D kinematics, 3D kinetics and electromyography (EMG) of the lower limbs during quasi-static or dynamic squatting activities. One study compared these two squatting conditions but only at low speed on healthy subjects, and provided no information on kinetics and EMG of the lower limbs. The purpose of the present study was to contrast simultaneous recordings of 3D kinematics, 3D kinetics and EMG of the lower limbs during quasi-stat ic and fast-dynamic squats in healthy and pathological subjects. Ten subjects were recruited: five healthy and five osteoarthritis subjects. A motion-capture system, force plate, and surface electrodes respectively recorded 3D kinematics, 3D kinetics and EMG of the lower limbs. Each subject performed a quasi-static squat and several fast-dynamic squats from 0° to 70° of knee flexion. The two squatting conditions were compared for positions where quasi-static and fast-dynamic knee flexion-extension angles were similar. Mean differences between quasi-static and fast-dynamic squats were 1.5° for rotations, 1.9 mm for translations, 2.1% of subjects' body weight for ground reaction forces, 6.6 Nm for torques, 11.2 mm for center of pressure, and 6.3% of maximum fast-dynamic electromyographic activities for EMG. Some significant differences (p<0.05) were found in internal rotation, anterior translation, vertical force and EMG. All differences between quasi-static and fast-dynamic squats were small. 69.5% of compared data were equivalent. In conclusion, this study showed that quasi-static and fast-dynamic squatting activities are comparable in terms of 3D kinematics, 3D kinetics and EMG, although some reservations still remain.

  7. Study on embedding fiber Bragg grating sensor into the 3D printing structure for health monitoring

    NASA Astrophysics Data System (ADS)

    Li, Ruiya; Tan, Yuegang; Zhou, Zude; Fang, Liang; Chen, Yiyang

    2016-10-01

    3D printing technology is a rapidly developing manufacturing technology, which is known as a core technology in the third industrial revolution. With the continuous improvement of the application of 3D printing products, the health monitoring of the 3D printing structure is particularly important. Fiber Bragg grating (FBG) sensing technology is a new type of optical sensing technology with unique advantages comparing to traditional sensing technology, and it has great application prospects in structural health monitoring. In this paper, the FBG sensors embedded in the internal structure of the 3D printing were used to monitor the static and dynamic strain variation of 3D printing structure during loading process. The theoretical result and experimental result has good consistency and the characteristic frequency detected by FBG sensor is consistent with the testing results of traditional accelerator in the dynamic experiment. The results of this paper preliminary validate that FBG embedded in the 3D printing structure can effectively detecting the static and dynamic stain change of the 3D printing structure, which provide some guidance for the health monitoring of 3D printing structure.

  8. Roughness receptivity studies in a 3-D boundary layer - Flight tests and computations

    NASA Astrophysics Data System (ADS)

    Carpenter, Andrew L.; Saric, William S.; Reed, Helen L.

    The receptivity of 3-D boundary layers to micron-sized, spanwise-periodic Discrete Roughness Elements (DREs) was studied. The DREs were applied to the leading edge of a 30-degree swept-wing at the wavelength of the most unstable disturbance. In this case, calibrated, multi-element hotfilm sensors were used to measure disturbance wall shear stress. The roughness height was varied from 0 to 50 microns. Thus, the disturbance-shear-stress amplitude variations were determined as a function of modulated DRE heights. The computational work was conducted parallel to the flight experiments. The complete viscous flowfield over the O-2 aircraft with the SWIFT model mounted on the port wing store pylon was successfully modeled and validated with the flight data. This highly accurate basic-state solution was incorporated into linear stability calculations and the wave growth associated with the crossflow instability was calculated.

  9. A 3D Numerical Study of Gravitational Instabilities in Young Circumbinary Disks

    NASA Astrophysics Data System (ADS)

    Cai, Kai; Michael, Scott; Durisen, Richard

    2013-07-01

    Gravitational instabilities (GIs) in protoplanetary disks have been suggested as one of the major formation mechanisms of giant planets. Theoretical and computational studies have indicated that certain family of GIs can be excited in a circumbinary disk, which could lead to enhanced protoplanet formation (e.g., Sellwood & Lin 1989, Boss 2006). We have carried out a 3D simulation of a gravitationally unstable circumbinary disk around a young Sun-like star and a 0.02-Msun companion, both inside the central hole of the disk. Here we present a preliminary comparison between this simulation and a similarly simulated circumstellar disk around a solar-mass star but without the low-mass companion. The GIs stimulated by the binary and those that arise spontaneously are quite different in structure and strength. However, no fragmentation is observed, even after many orbital periods as measured in the outer disk.

  10. Study of negative hydrogen ion beam optics using the 3D3V PIC model

    SciTech Connect

    Miyamoto, K.; Nishioka, S.; Goto, I.; Hatayama, A.; Hanada, M.; Kojima, A.

    2015-04-08

    The mechanism of negative ion extraction under real conditions with the complex magnetic field is studied by using the 3D PIC simulation code. The extraction region of the negative ion source for the negative ion based neutral beam injection system in fusion reactors is modelled. It is shown that the E x B drift of electrons is caused by the magnetic filter and the electron suppression magnetic field, and the resultant asymmetry of the plasma meniscus. Furthermore, it is indicated that that the asymmetry of the plasma meniscus results in the asymmetry of negative ion beam profile including the beam halo. It could be demonstrated theoretically that the E x B drift is not significantly weakened by the elastic collisions of the electrons with neutral particles.

  11. An isostatic study of the Karoo basin and underlying lithosphere in 3-D

    NASA Astrophysics Data System (ADS)

    Scheiber-Enslin, Stephanie E.; Ebbing, Jörg; Webb, Susan J.

    2016-08-01

    A 3-D density model of the crust and upper mantle beneath the Karoo basin is presented here. The model is constrained using potential field, borehole and seismic data. Uplift of the basin by the end of the Cretaceous has resulted in an unusually high plateau (>1000 m) covering a large portion of South Africa. Isostatic studies show the topography is largely compensated by changes in Moho depths (˜35 km on-craton and >45 km off-craton) and changes in lithospheric mantle densities between the Kaapvaal Craton and surrounding regions (˜50 kg m-3 increase from on- to off-craton). This density contrast is determined by inverted satellite gravity and gravity gradient data. The highest topography along the edge of the plateau (>1200 m) and a strong Bouguer gravity low over Lesotho, however, can only be explained by a buoyant asthenosphere with a density decrease of around 40 kg m-3.

  12. Uncertainty studies of topographical measurements on steel surface corrosion by 3D scanning electron microscopy.

    PubMed

    Kang, K W; Pereda, M D; Canafoglia, M E; Bilmes, P; Llorente, C; Bonetto, R

    2012-02-01

    Pitting corrosion is a damage mechanism quite serious and dangerous in both carbon steel boiler tubes for power plants which are vital to most industries and stainless steels for orthopedic human implants whose demand, due to the increase of life expectation and rate of traffic accidents, has sharply increased. Reliable methods to characterize this kind of damage are becoming increasingly necessary, when trying to evaluate the advance of damage and to establish the best procedures for component inspection in order to determine remaining lives and failure mitigation. A study about the uncertainties on the topographies of corrosion pits from 3D SEM images, obtained at low magnifications (where errors are greater) and different stage tilt angles were carried out using an in-house software previously developed. Additionally, measurements of pit depths on biomaterial surfaces, subjected to two different surface treatments on stainless steels, were carried out. The different depth distributions observed were in agreement with electrochemical measurements.

  13. Structural and property studies on metal-organic compounds with 3-D supramolecular network

    NASA Astrophysics Data System (ADS)

    Zhang, Qi-Ying; Ma, Ke-Fang; Xiao, Hong-Ping; Li, Xin-Hua; Shi, Qian

    2014-07-01

    Two carboxylato-bridged allomeric compounds, {[Cu2(dbsa)2(hmt) (H2O)4]1/2·2H2O}n (1), {[Ni(dbsa)(H2O)2]1/2[Ni(dbsa)(hmt)(H2O)2]1/2·2H2O}n (2) (H2dbsa=meso-2,3-dibromosuccinic acid, hmt=hexamethylenetetramine) have been synthesized and characterized by X-ray structral analyses. The metal ions have two kinds of coordination fashion in one unit, and bridged by carboxylate and hmt ligands along with weak interactions existing in the solid structure, forming a 3-D supramolecular network. Variable-temperature magnetic property studies reveal the existence of antiferromagnetic interactions in 1 and 2 with g=2.2, J1=-3.5 cm-1, J2=-2.8 cm-1 for 1, and g=2.1, J=-3.5 cm-1 for 2.

  14. Genetic and Environmental Contributions to Facial Morphological Variation: A 3D Population-Based Twin Study

    PubMed Central

    Djordjevic, Jelena; Zhurov, Alexei I.; Richmond, Stephen

    2016-01-01

    Introduction Facial phenotype is influenced by genes and environment; however, little is known about their relative contributions to normal facial morphology. The aim of this study was to assess the relative genetic and environmental contributions to facial morphological variation using a three-dimensional (3D) population-based approach and the classical twin study design. Materials and Methods 3D facial images of 1380 female twins from the TwinsUK Registry database were used. All faces were landmarked, by manually placing 37 landmark points, and Procrustes registered. Three groups of traits were extracted and analysed: 19 principal components (uPC) and 23 principal components (sPC), derived from the unscaled and scaled landmark configurations respectively, and 1275 linear distances measured between 51 landmarks (37 manually identified and 14 automatically calculated). The intraclass correlation coefficients, rMZ and rDZ, broad-sense heritability (h2), common (c2) and unique (e2) environment contributions were calculated for all traits for the monozygotic (MZ) and dizygotic (DZ) twins. Results Heritability of 13 uPC and 17 sPC reached statistical significance, with h2 ranging from 38.8% to 78.5% in the former and 30.5% to 84.8% in the latter group. Also, 1222 distances showed evidence of genetic control. Common environment contributed to one PC in both groups and 53 linear distances (4.3%). Unique environment contributed to 17 uPC and 20 sPC and 1245 distances. Conclusions Genetic factors can explain more than 70% of the phenotypic facial variation in facial size, nose (width, prominence and height), lips prominence and inter-ocular distance. A few traits have shown potential dominant genetic influence: the prominence and height of the nose, the lower lip prominence in relation to the chin and upper lip philtrum length. Environmental contribution to facial variation seems to be the greatest for the mandibular ramus height and horizontal facial asymmetry. PMID

  15. A Morpho-kinematic and Spectroscopic study of Bipolar Planetary Nebulae

    NASA Astrophysics Data System (ADS)

    Clyne, Niall

    2015-09-01

    In this thesis, studies of the kinematic properties for a sample of Galactic bipolar planetary nebulae, based on optical and infrared observations, were performed using a morpho-kinematic code, optical and NIR diagnostic diagrams, and techniques using data analyses. The mechanisms that form complex bipolar planetary nebulae remain unclear, and their shapes can be generated either as a planetary or symbiotic nebula. The origin of the material ionised by the white dwarf is very different in these two scenarios, and it complicates the understanding of the morphologies of planetary nebulae. The physical properties, structure, and dynamics of the bipolar nebulae, MyCn 18, M 2-9, Mz 3, Hen 2-104, and Abell 14, are each investigated in detail with the aim of understanding their nature, shaping mechanisms, and evolutionary history. For MyCn 18, VLT infrared images, VLT ISAAC infrared spectra, and long-slit optical echelle spectra are used to investigate the inner and outer regions of the nebula. The morpho-kinematic modelling tool shape was used to firmly constrain the structure and kinematics of the source. A timescale analysis was used to help determine the kinematical age of the nebula and its main components. A spectroscopic study of MyCn 18's central region reveals the detailed make-up of its nebular composition. Molecular hydrogen, atomic helium, and Brackett gamma emission are detected in the central regions. ISAAC spectra from a slit position along the narrow waist of the nebula demonstrate that the ionised gas resides closer to the centre of the nebula than the molecular emission. A final reconstructed 3-D model of MyCn 18 was generated, providing kinematical information on the expansion velocity of its nebular components by means of position-velocity arrays (or observed long-slit spectra). A kinematical age of the nebula and its components were obtained using the position-velocity arrays and timescale analysis. For M 2-9, Mz 3, and Hen 2-104, long-slit optical

  16. Accuracy of 3-D reconstruction with occlusions.

    PubMed

    Begon, Mickaël; Lacouture, Patrick

    2010-02-01

    A marker has to be seen by at least two cameras for its three-dimensional (3-D) reconstruction, and the accuracy can be improved with more cameras. However, a change in the set of cameras used in the reconstruction can alter the kinematics. The purpose of this study was to quantify the harmful effect of occlusions on two-dimensional (2-D) images and to make recommendations about the signal processing. A reference kinematics data set was collected for a three degree-of-freedom linkage with three cameras of a commercial motion analysis system without any occlusion on the 2-D images. In the 2-D images, some occlusions were artificially created based on trials of real cyclic motions. An interpolation of 2-D trajectories before the 3-D reconstruction and two filters (Savitsky-Golay and Butterworth filters) after reconstruction were successively applied to minimize the effect of the 2-D occlusions. The filter parameters were optimized by minimizing the root mean square error between the reference and the filtered data. The optimal parameters of the filters were marker dependent, whereas no filter was necessary after a 2-D interpolation. As the occlusions cause systematic error in the 3-D reconstruction, the interpolation of the 2-D trajectories is more appropriate than filtering the 3-D trajectories.

  17. Study of City Landscape Heritage Using Lidar Data and 3d-City Models

    NASA Astrophysics Data System (ADS)

    Rubinowicz, P.; Czynska, K.

    2015-04-01

    In contemporary town planning protection of urban landscape is a significant issue. It regards especially those cities, where urban structures are the result of ages of evolution and layering of historical development process. Specific panoramas and other strategic views with historic city dominants can be an important part of the cultural heritage and genius loci. Other hand, protection of such expositions introduces limitations for future based city development. Digital Earth observation techniques creates new possibilities for more accurate urban studies, monitoring of urbanization processes and measuring of city landscape parameters. The paper examines possibilities of application of Lidar data and digital 3D-city models for: a) evaluation of strategic city views, b) mapping landscape absorption limits, and c) determination protection zones, where the urbanization and buildings height should be limited. In reference to this goal, the paper introduces a method of computational analysis of the city landscape called Visual Protection Surface (VPS). The method allows to emulate a virtual surface above the city including protection of a selected strategic views. The surface defines maximum height of buildings in such a way, that no new facility can be seen in any of selected views. The research includes also analyses of the quality of simulations according the form and precision of the input data: airborne Lidar / DSM model and more advanced 3D-city models (incl. semantic of the geometry, like in CityGML format). The outcome can be a support for professional planning of tall building development. Application of VPS method have been prepared by a computer program developed by the authors (C++). Simulations were carried out on an example of the city of Dresden.

  18. 3D Inversion of complex resistivity data: Case study on Mineral Exploration Site.

    NASA Astrophysics Data System (ADS)

    Son, Jeong-Sul; Kim, Jung-ho; Park, Sam-gyu; Park, My-Kyung

    2016-04-01

    Complex resistivity (CR) method is a frequency domain induced polarization (IP) method. It is also known as Spectral IP (SIP) method, if wider frequencies are used in data acquisition and interpretation. Although it takes more times than conventional time domain IP method, its data quality is more stable because its data acquisition which measures amplitude and phase is done when the source current is being injected. Our research group has been studying the modeling and inversion algorithms of complex resistivity (CR) method since several years ago and recently applied developed algorithms to various real field application. Due to tough terrain in our country, Profile survey and 2D interpretation were generally used. But to get more precise interpretation, three dimensional modeling and inversion algorithm is required. We developed three dimensional inversion algorithm for this purpose. In the inversion, we adopt the method of adaptive lagraingian multiplier which is automatically set based on the size of error misfit and model regularization norm. It was applied on the real data acquired for mineral exploration sites. CR data was acquired with the Zeta system, manufactured by Zonge Co. In the inversion, only the lower frequency data is used considering its quality and developed 3D inversion algorithm was applied to the acquired data set. Its results were compared to those of time domain IP data conducted at the same site. Resistivity image sections of CR and conventional resistivity method were almost identical. Phase anomalies were well matched with chargeability anomalies and the mining history of the test site. Each anomalies were well discriminated in 3D interpretation than those of 2D. From those experiments, we know that CR method was very effective for the mineral exploration.

  19. Confirming the Potential of Systems Containing Strangeness for 3D Structure Studies of the Proton

    NASA Astrophysics Data System (ADS)

    Ali, Salina; Horn, Tanja; Carmignotto, Marco

    2017-01-01

    The additional flavor degree of freedom in kaon electroproduction provides a unique opportunity to study the mechanism underlying strangeness production and the transition from hadronic to partonic degrees of freedom in exclusive processes. At sufficiently high energies, where soft non-perturbative and hard physics have been shown to factorize, the Generalized Parton Distributions provide a spatial tomography of the nucleon. The applicability of this formalism can be experimentally verified. The E12-09-011 experiment at the 12 GeV Jefferson Lab aims to test the expected approach of the hard scattering regime through precision measurements of the fully separated exclusive kaon production cross section, and in particular the relative contributions and kinematic dependencies of the longitudinal and transverse cross sections. The longitudinal cross section also allows one to test the kaon pole dominance and could allow for kaon form factor extractions. In this talk, I will present the current status and discuss the outlook on future studies of strange quarks with kaon production as well as the particle identification requirements, and possible kaon form factor extractions at a 12-GeV Jefferson Lab. Supported in part by NSF grants PHY-1306227 and PHY-1306418.

  20. Distal Insertional Footprint of the Brachialis Muscle: 3D Morphometric Study

    PubMed Central

    Kamineni, Srinath; Bachoura, Abdo; Behrens, William; Kamineni, Ellora; Deane, Andrew

    2015-01-01

    Objective. The purpose of this study is to describe the three-dimensional morphometry of the brachialis muscle at its distal attachment to the ulna. Methods. Fifty cadaveric elbows were dissected and the brachialis distal insertion was isolated on the ulna bone and probed with a three-dimensional digitizer, to create a three-dimensional model of the footprint. Measurements and analysis of each footprint shape were recorded and compared based on gender and size. Results. There was significant gender difference in the surface length (P= 0.002) and projected length (P= 0.001) of the brachialis footprint. The shapes of the footprint also differed among the specimens. Conclusion. The shape of the brachialis muscle insertion differed among all the specimens without significant variation in gender or sides. There was also a significant difference in muscle length between males and females with little difference in the width and surface area. Significance. The information obtained from this study is important for kinematic understanding and surgical procedures around the elbow joint as well as the understanding of the natural age related anatomy of the brachialis footprint morphology. PMID:26640711

  1. The radiological feature of anterior occiput-to-axis screw fixation as it guides the screw trajectory on 3D printed models: a feasibility study on 3D images and 3D printed models.

    PubMed

    Wu, Ai-Min; Wang, Sheng; Weng, Wan-Qing; Shao, Zhen-Xuan; Yang, Xin-Dong; Wang, Jian-Shun; Xu, Hua-Zi; Chi, Yong-Long

    2014-12-01

    Anterior occiput-to-axis screw fixation is more suitable than a posterior approach for some patients with a history of posterior surgery. The complex osseous anatomy between the occiput and the axis causes a high risk of injury to neurological and vascular structures, and it is important to have an accurate screw trajectory to guide anterior occiput-to-axis screw fixation. Thirty computed tomography (CT) scans of upper cervical spines were obtained for three-dimensional (3D) reconstruction. Cylinders (1.75 mm radius) were drawn to simulate the trajectory of an anterior occiput-to-axis screw. The imitation screw was adjusted to 4 different angles and measured, as were the values of the maximized anteroposterior width and the left-right width of the occiput (C0) to the C1 and C1 to C2 joints. Then, the 3D models were printed, and an angle guide device was used to introduce the screws into the 3D models referring to the angles calculated from the 3D images. We found the screw angle ranged from α1 (left: 4.99±4.59°; right: 4.28±5.45°) to α2 (left: 20.22±3.61°; right: 19.63±4.94°); on the lateral view, the screw angle ranged from β1 (left: 13.13±4.93°; right: 11.82±5.64°) to β2 (left: 34.86±6.00°; right: 35.01±5.77°). No statistically significant difference was found between the data of the left and right sides. On the 3D printed models, all of the anterior occiput-to-axis screws were successfully introduced, and none of them penetrated outside of the cortex; the mean α4 was 12.00±4.11 (left) and 12.25±4.05 (right), and the mean β4 was 23.44±4.21 (left) and 22.75±4.41 (right). No significant difference was found between α4 and β4 on the 3D printed models and α3 and β3 calculated from the 3D digital images of the left and right sides. Aided with the angle guide device, we could achieve an optimal screw trajectory for anterior occiput-to-axis screw fixation on 3D printed C0 to C2 models.

  2. A kinematic study of Tycho's supernova remnant

    NASA Astrophysics Data System (ADS)

    Hughes, P. J.; Sato, T.

    2016-06-01

    Thanks to its confirmed nature as the remnant of a standard Type Ia supernova from spectroscopy of its light echo, Tycho's supernova remnant is a unique object that can provide a new perspective into thermonuclear supernova explosions. More than 400 years after its discovery as a supernova in November 1572, the remnant is now spread out over an 8 arcminute diameter region in a fairly symmetric, but patchy, shell-like morphology. The remnant's thermal X-ray emission is dominated by a strong Si Kalpha line and also shows line emission from other species such as S, Ar, Ca, and Fe. Existing proper motion and X-ray line width measurements indicate that Tycho's Si-rich ejecta shell is expanding at ~4700 km/s. We have taken advantage of the huge number of Si line photons in the 750-ks Chandra ACIS observation from 2009 to make the first direct velocity measurements of ejecta in Tycho. The patchy nature of the ejecta shell allows for identification of red- and blue-shifted clumps of emission from the receding and approaching hemispheres. We use nonequilibrium ionization thermal models to jointly fit both ACIS-S and ACIS-I observations to determine the radial expansion velocity of individual clumps and associated systematic uncertainty. Red-shifted clumps have speeds of 3500-7800 km/s and blue-shifted clumps 1600--5000 km/s with a systematic uncertainty of 500-2000 km/s determined by intercomparison of the ACIS-S and ACIS-I spectral results. From our Chandra radial analysis of surface brightness, centroid energy, and line width, we have confirmed previous line width measurements from Suzaku, but are able to utilize finer radial bins that reveal additional structure in the kinematics of Tycho. In particular the Si and S line widths reach a deep minimum at the position of the peak surface brightness near the remnant's edge and where Doppler broadening from the shell expansion is minimum. From the measured line widths and assuming that Doppler and turbulent broadening can be

  3. Study on the Construction and Application of 3D Geographic Information Services for the Smart City

    NASA Astrophysics Data System (ADS)

    Mao, W.-Q.

    2014-04-01

    Smart City, whose main characteristics are intelligence and interconnection capability, has become an important goal of some cities' development. This paper, based on urban three-dimensional geographic information characteristics, analyses 3D geographic information requirements in the Smart City construction and development process, proposes construction and management methods for 3D geographic information. Furthermore, this paper takes Shanghai Geographic Information Public Service Platform as an example, discusses 3D geographic information application in multiple fields, and proves that it is an effective ways to promote Intelligent City construction.

  4. The applicability of 3D Doppler tomography to studies of polars

    NASA Astrophysics Data System (ADS)

    Kononov, D. A.; Agafonov, M. I.; Sharova, O. I.; Bisikalo, D. V.; Zhilkin, A. G.; Sidorov, M. Yu.

    2014-12-01

    The applicability of 3D Doppler tomography to mapping gas flows in polars is considered. Synthetic profiles of emission lines are calculated using solutions (for the densities, temperatures, and velocity components) obtained from 3D MHD modeling, which are then used to construct 3D Doppler tomograms in the velocity space ( V x , V y , V z ). Subsequent analysis of these tomograms applying observational constraints (the signal-to-noise ratio, number of input profiles, etc.) enables evaluation of limits to the method's applicability.

  5. Evolution of 3-D geologic framework modeling and its application to groundwater flow studies

    USGS Publications Warehouse

    Blome, Charles D.; Smith, David V.

    2012-01-01

    In this Fact Sheet, the authors discuss the evolution of project 3-D subsurface framework modeling, research in hydrostratigraphy and airborne geophysics, and methodologies used to link geologic and groundwater flow models.

  6. 3-D QSARS FOR RANKING AND PRIORITIZATION OF LARGE CHEMICAL DATASETS: AN EDC CASE STUDY

    EPA Science Inventory

    The COmmon REactivity Pattern (COREPA) approach is a three-dimensional structure activity (3-D QSAR) technique that permits identification and quantification of specific global and local steroelectronic characteristics associated with a chemical's biological activity. It goes bey...

  7. EMPulse, a new 3-D simulation code for electromagnetic pulse studies

    NASA Astrophysics Data System (ADS)

    Cohen, Bruce; Eng, Chester; Farmer, William; Friedman, Alex; Grote, David; Kruger, Hans; Larson, David

    2016-10-01

    EMPulse is a comprehensive and modern 3-D simulation code for electro-magnetic pulse (EMP) formation and propagation studies, being developed at LLNL as part of a suite of codes to study E1 EMP originating from prompt gamma rays. EMPulse builds upon the open-source Warp particle-in-cell code framework developed by members of this team and collaborators at other institutions. The goal of this endeavor is a new tool enabling the detailed and self-consistent study of multi-dimensional effects in geometries that have typically been treated only approximately. Here we present an overview of the project, the models and methods that have been developed and incorporated into EMPulse, tests of these models, comparisons to simulations undertaken in CHAP-lite (derived from the legacy code CHAP due to C. Longmire and co-workers), and some approaches to increased computational efficiency being studied within our project. This work was performed under the auspices of the U.S. DOE by Lawrence Livermore National Security, LLC, Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  8. 3D high-resolution two-photon crosslinked hydrogel structures for biological studies.

    PubMed

    Brigo, Laura; Urciuolo, Anna; Giulitti, Stefano; Giustina, Gioia Della; Tromayer, Maximilian; Liska, Robert; Elvassore, Nicola; Brusatin, Giovanna

    2017-03-25

    Hydrogels are widely used as matrices for cell growth due to the their tuneable chemical and physical properties, which mimic the extracellular matrix of natural tissue. The microfabrication of hydrogels into arbitrarily complex 3D structures is becoming essential for numerous biological applications, and in particular for investigating the correlation between cell shape and cell function in a 3D environment. Micrometric and sub-micrometric resolution hydrogel scaffolds are required to deeply investigate molecular mechanisms behind cell-matrix interaction and downstream cellular processes. We report the design and development of high resolution 3D gelatin hydrogel woodpile structures by two-photon crosslinking. Hydrated structures of lateral linewidth down to 0.5 µm, lateral and axial resolution down to a few µm are demonstrated. According to the processing parameters, different degrees of polymerization are obtained, resulting in hydrated scaffolds of variable swelling and deformation. The 3D hydrogels are biocompatible and promote cell adhesion and migration. Interestingly, according to the polymerization degree, 3D hydrogel woodpile structures show variable extent of cell adhesion and invasion. Human BJ cell lines show capability of deforming 3D micrometric resolved hydrogel structures.

  9. Coupling high resolution 3D point clouds from terrestrial LiDAR with high precision displacement time series from GB-InSAR to understand landslide kinematic: example of the La Perraire instability, Swiss Alps.

    NASA Astrophysics Data System (ADS)

    Michoud, Clément; Baillifard, François; Harald Blikra, Lars; Derron, Marc-Henri; Jaboyedoff, Michel; Kristensen, Lene; Leva, Davide; Metzger, Richard; Rivolta, Carlo

    2014-05-01

    Terrestrial Laser Scanning and Ground-Based Radar Interferometry have changed our perception and interpretation of slope activities for the last 20 years and are now routinely used for monitoring and even early warning purposes. Terrestrial LiDAR allows indeed to model topography with very high point density, even in steep slopes, and to extract 3D displacements of rock masses by comparing successive datasets. GB-InSAR techniques are able to detect mm displacements over large areas. Nevertheless, both techniques suffer of some limitations. The precision of LiDAR devices actually limits its ability to monitor very slow-moving landslides, as well as by the dam resolution and the particular geometry (in azimuth/range) of GB-InSAR data may complicate their interpretations. To overcome those limitations, tools were produced to truly combine strong advantages of both techniques, by coupling high resolution geometrical data from terrestrial LiDAR or photogrammetry with high precision displacement time series from GB-InSAR. We thus developed a new exportation module into the processing chain of LiSAmobile (GB-InSAR) devices in order to wrap radar results from their particular geometry on high resolution 3D point clouds with cm mean point spacing. Furthermore, we also added new importation and visualization functionalities into Coltop3D (software for geological interpretations of laser scanning data) to display those results in 3D and even analyzing displacement time series. This new method has also been optimized to create as few and small files as possible and for time processing. Advantages of coupling terrestrial LiDAR and GB-InSAR data will be illustrated on the La Perraire instability, an active large rockslide involving frequent rockfalls and threatening inhabitant within the Val de Bagnes in the Swiss Alps. This rock mass, monitored by LiDAR and GPS since 2006, is huge enough and long-term movements are big (up to 1.6 m in 6 years) and complex enough to make

  10. Comparative study of DSC-PWI and 3D-ASL in ischemic stroke patients.

    PubMed

    Zhang, Shui-xia; Yao, Yi-hao; Zhang, Shun; Zhu, Wen-jie; Tang, Xiang-yu; Qin, Yuan-yuan; Zhao, Ling-yun; Liu, Cheng-xia; Zhu, Wen-zhen

    2015-12-01

    The purpose of this study was to quantitatively analyze the relationship between three dimensional arterial spin labeling (3D-ASL) and dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) in ischemic stroke patients. Thirty patients with ischemic stroke were included in this study. All subjects underwent routine magnetic resonance imaging scanning, diffusion weighted imaging (DWI), magnetic resonance angiography (MRA), 3D-ASL and DSC-PWI on a 3.0T MR scanner. Regions of interest (ROIs) were drawn on the cerebral blood flow (CBF) maps (derived from ASL) and multi-parametric DSC perfusion maps, and then, the absolute and relative values of ASL-CBF, DSC-derived CBF, and DSC-derived mean transit time (MTT) were calculated. The relationships between ASL and DSC parameters were analyzed using Pearson's correlation analysis. Receiver operative characteristic (ROC) curves were performed to define the thresholds of relative value of ASL-CBF (rASL) that could best predict DSC-CBF reduction and MTT prolongation. Relative ASL better correlated with CBF and MTT in the anterior circulation with the Pearson correlation coefficients (R) values being 0.611 (P<0.001) and-0.610 (P<0.001) respectively. ROC curves demonstrated that when rASL ≤0.585, the sensitivity, specificity and accuracy for predicting ROIs with rCBF<0.9 were 92.3%, 63.6% and 76.6% respectively. When rASL ≤0.952, the sensitivity, specificity and accuracy for predicting ROIs rMTT>1.0 were 75.7%, 89.2% and 87.8% respectively. ASL-CBF map has better linear correlations with DSC-derived parameters (DSC-CBF and MTT) in anterior circulation in ischemic stroke patients. Additionally, when rASL is lower than 0.585, it could predict DSC-CBF decrease with moderate accuracy. If rASL values range from 0.585 to 0.952, we just speculate the prolonged MTT.

  11. Feasibility study of 3D cardiac imaging using a portable conebeam scanner

    NASA Astrophysics Data System (ADS)

    Petrov, Ivailo; Helm, Patrick A.; Drangova, Maria

    2012-03-01

    While the Medtronic O-arm was developed for image-guidance applications during orthopedic procedures, it has potential to assist in cardiac surgical and electrophysiological applications; the purpose of this study was to evaluate the feasibility of using a mobile conebeam imaging system (O-arm) for gated cardiac imaging. In an in vivo study (two pigs), projection data from four independently acquired breath-held scans were combined to obtain cardiac gated 3D images. Projection images were acquired during the infusion of contrast agent and while tracking the ECG. Both standard and high-definition modes of the O-arm were evaluated. Projection data were retrospectively combined to generate images corresponding to systole and diastole; different acceptance windows were investigated. The contrast to noise ratio (CNR) between blood and myocardium was compared for the different gating strategies. Gated cardiac images were successfully reconstructed with as few as two scans combined (CNR = 2.5) and a window of 200 ms. Improved image quality was achieved when selecting views based on the minimum time from the selected phase point in the cardiac cycle, rather than a fixed window; in this case the effective temporal window increased to 475 ms for two scans. The O-arm has the potential to be used as a mobile cardiac imaging system, capable of three-dimensional imaging.

  12. 3D Printing Surgical Implants at the clinic: A Experimental Study on Anterior Cruciate Ligament Reconstruction.

    PubMed

    Liu, An; Xue, Guang-huai; Sun, Miao; Shao, Hui-feng; Ma, Chi-yuan; Gao, Qing; Gou, Zhong-ru; Yan, Shi-gui; Liu, Yan-ming; He, Yong

    2016-02-15

    Desktop three-dimensional (3D) printers (D3DPs) have become a popular tool for fabricating personalized consumer products, favored for low cost, easy operation, and other advantageous qualities. This study focused on the potential for using D3DPs to successfully, rapidly, and economically print customized implants at medical clinics. An experiment was conducted on a D3DP-printed anterior cruciate ligament surgical implant using a rabbit model. A well-defined, orthogonal, porous PLA screw-like scaffold was printed, then coated with hydroxyapatite (HA) to improve its osteoconductivity. As an internal fixation as well as an ideal cell delivery system, the osteogenic scaffold loaded with mesenchymal stem cells (MSCs) were evaluated through both in vitro and in vivo tests to observe bone-ligament healing via cell therapy. The MSCs suspended in Pluronic F-127 hydrogel on PLA/HA screw-like scaffold showed the highest cell proliferation and osteogenesis in vitro. In vivo assessment of rabbit anterior cruciate ligament models for 4 and 12 weeks showed that the PLA/HA screw-like scaffold loaded with MSCs suspended in Pluronic F-127 hydrogel exhibited significant bone ingrowth and bone-graft interface formation within the bone tunnel. Overall, the results of this study demonstrate that fabricating surgical implants at the clinic (fab@clinic) with D3DPs can be feasible, effective, and economical.

  13. A 3D velocimetry study of the flow through prosthetic heart valves

    NASA Astrophysics Data System (ADS)

    Ledesma, R.; Zenit, R.; Pulos, G.; Sanchez, E.; Juarez, A.

    2006-11-01

    Blood damage commonly appears in medical valve prothesis. It is a mayor concern for the designers and surgeons. It is well known that this damage and other complications result from the modified fluid dynamics through the replacement valve. To evaluate the performance of prosthetic heart valves, it is necessary to study the flow through them. To conduct this study , we have built a flow channel that emulates cardiac conditions and allows optical access such that a 3D-PIV velocimetry system could be used. The experiments are aimed to reconstruct the downstream structure of the flow through a mechanical and a bio-material tricuspid heart valve prothesis. Preliminary results show that the observed coherent structures can be related with haemolysis and trombosis, illnesses commonly found in valve prothesis recipients. The mean flow, the levels of strain rate and the turbulence intensity generated by the valves can also be directly related to blood damage. In general, bio-material made valves tend to reduce these complications.

  14. Potentiometric and spectroscopic study of the interaction of 3d transition metal ions with inositol hexakisphosphate

    NASA Astrophysics Data System (ADS)

    Veiga, Nicolás; Macho, Israel; Gómez, Kerman; González, Gabriel; Kremer, Carlos; Torres, Julia

    2015-10-01

    Among myo-inositol phosphates, the most abundant in nature is the myo-inositol hexakisphosphate, InsP6. Although it is known to be vital to cell functioning, the biochemical research into its metabolism needs chemical and structural analysis of all the protonation, complexation and precipitation processes that it undergoes in the biological media. In view of its high negative charge at physiological level, our group has been leading a thorough research into the InsP6 chemical and structural behavior in the presence of the alkali and alkaline earth metal ions essential for life. The aim of this article is to extend these studies, dealing with the chemical and structural features of the InsP6 interaction with biologically relevant 3d transition metal ions (Fe(II), Fe(III), Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)), in a non-interacting medium and under simulated physiological conditions. The metal-complex stability constants were determined by potentiometry, showing under ligand-excess conditions the formation of mononuclear species in different protonation states. Under metal ion excess, polymetallic species were detected for Fe(II), Fe(III), Zn(II) and Cu(II). Additionally, the 31P NMR and UV-vis spectroscopic studies provided interesting structural aspects of the strong metal ion-InsP6 interaction.

  15. 3D Printing Surgical Implants at the clinic: A Experimental Study on Anterior Cruciate Ligament Reconstruction

    PubMed Central

    Liu, An; Xue, Guang-huai; Sun, Miao; Shao, Hui-feng; Ma, Chi-yuan; Gao, Qing; Gou, Zhong-ru; Yan, Shi-gui; Liu, Yan-ming; He, Yong

    2016-01-01

    Desktop three-dimensional (3D) printers (D3DPs) have become a popular tool for fabricating personalized consumer products, favored for low cost, easy operation, and other advantageous qualities. This study focused on the potential for using D3DPs to successfully, rapidly, and economically print customized implants at medical clinics. An experiment was conducted on a D3DP-printed anterior cruciate ligament surgical implant using a rabbit model. A well-defined, orthogonal, porous PLA screw-like scaffold was printed, then coated with hydroxyapatite (HA) to improve its osteoconductivity. As an internal fixation as well as an ideal cell delivery system, the osteogenic scaffold loaded with mesenchymal stem cells (MSCs) were evaluated through both in vitro and in vivo tests to observe bone-ligament healing via cell therapy. The MSCs suspended in Pluronic F-127 hydrogel on PLA/HA screw-like scaffold showed the highest cell proliferation and osteogenesis in vitro. In vivo assessment of rabbit anterior cruciate ligament models for 4 and 12 weeks showed that the PLA/HA screw-like scaffold loaded with MSCs suspended in Pluronic F-127 hydrogel exhibited significant bone ingrowth and bone-graft interface formation within the bone tunnel. Overall, the results of this study demonstrate that fabricating surgical implants at the clinic (fab@clinic) with D3DPs can be feasible, effective, and economical. PMID:26875826

  16. Gait Strategy in Patients with Ehlers-Danlos Syndrome Hypermobility Type: A Kinematic and Kinetic Evaluation Using 3D Gait Analysis

    ERIC Educational Resources Information Center

    Galli, Manuela; Cimolin, Veronica; Rigoldi, Chiara; Castori, Marco; Celletti, Claudia; Albertini, Giorgio; Camerota, Filippo

    2011-01-01

    The aim of this study was to quantify the gait patterns of adults with joint hypermobility syndrome/Ehlers-Danlos syndrome (JHS/EDS-HT) hypermobility type, using Gait Analysis. We quantified the gait strategy in 12 JHS/EDS-HT adults individuals (age: 43.08 + 6.78 years) compared to 20 healthy controls (age: 37.23 plus or minus 8.91 years), in…

  17. 3D dynamic rupture simulation and local tomography studies following the 2010 Haiti earthquake

    NASA Astrophysics Data System (ADS)

    Douilly, Roby

    temporary station deployments. We only considered events that had at least 6 P and 6 S arrivals, and an azimuthal gap less then 180 degrees, to simultaneously invert for hypocenters and 3D velocity structure in southern Haiti. We used the program VELEST to define a minimum 1D velocity model, which was then used as a starting model in the computer algorithm SIMULPS14 to produce the 3D tomography. Our results show a pronounced low velocity zone across the Logne fault, which is consistent with the sedimentary basin location from the geologic map. We also observe a southeast low velocity zone, which is consistent with a predefined structure in the morphology. Low velocity structure usually correlates with broad zones of deformation, such as the presence of cracks or faults, or from the presence of fluid in the crust. This work provides information that can be used in future studies focusing on how changes in material properties can affect rupture propagation, which is useful to assess the seismic hazard that Haiti and other regions are facing.

  18. 3D Airborne Electromagnetic Inversion: A case study from the Musgrave Region, South Australia

    NASA Astrophysics Data System (ADS)

    Cox, L. H.; Wilson, G. A.; Zhdanov, M. S.; Sunwall, D. A.

    2012-12-01

    Geophysicists know and accept that geology is inherently 3D, and is resultant from complex, overlapping processes related to genesis, metamorphism, deformation, alteration, weathering, and/or hydrogeology. Yet, the geophysics community has long relied on qualitative analysis, conductivity depth imaging (CDIs), 1D inversion, and/or plate modeling. There are many reasons for this deficiency, not the least of which has been the lack of capacity for historic 3D AEM inversion algorithms to invert entire surveys so as to practically affect exploration decisions. Our recent introduction of a moving sensitivity domain (footprint) methodology has been a paradigm shift in AEM interpretation. The basis of this method is that one needs only to calculate the responses and sensitivities for that part of the 3D earth model that is within the AEM system's sensitivity domain (footprint), and then superimpose all sensitivity domains into a single, sparse sensitivity matrix for the entire 3D earth model which is then updated in a regularized inversion scheme. This has made it practical to rigorously invert entire surveys with thousands of line kilometers of AEM data to mega-cell 3D models in hours using multi-processor workstations. Since 2010, over eighty individual projects have been completed for Aerodat, AEROTEM, DIGHEM, GEOTEM, HELITEM, HoisTEM, MEGATEM, RepTEM, RESOLVE, SkyTEM, SPECTREM, TEMPEST, and VTEM data from Australia, Brazil, Canada, Finland, Ghana, Peru, Tanzania, the US, and Zambia. Examples of 3D AEM inversion have been published for a variety of applications, including mineral exploration, oil sands exploration, salinity, permafrost, and bathymetry mapping. In this paper, we present a comparison of 3D inversions for SkyTEM, SPECTREM, TEMPET and VTEM data acquired over the same area in the Musgrave region of South Australia for exploration under cover.

  19. Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

    PubMed Central

    Hendriks, Delilah F. G.; Fredriksson Puigvert, Lisa; Messner, Simon; Mortiz, Wolfgang; Ingelman-Sundberg, Magnus

    2016-01-01

    Drug-induced cholestasis (DIC) is poorly understood and its preclinical prediction is mainly limited to assessing the compound’s potential to inhibit the bile salt export pump (BSEP). Here, we evaluated two 3D spheroid models, one from primary human hepatocytes (PHH) and one from HepaRG cells, for the detection of compounds with cholestatic liability. By repeatedly co-exposing both models to a set of compounds with different mechanisms of hepatotoxicity and a non-toxic concentrated bile acid (BA) mixture for 8 days we observed a selective synergistic toxicity of compounds known to cause cholestatic or mixed cholestatic/hepatocellular toxicity and the BA mixture compared to exposure to the compounds alone, a phenomenon that was more pronounced after extending the exposure time to 14 days. In contrast, no such synergism was observed after both 8 and 14 days of exposure to the BA mixture for compounds that cause non-cholestatic hepatotoxicity. Mechanisms behind the toxicity of the cholestatic compound chlorpromazine were accurately detected in both spheroid models, including intracellular BA accumulation, inhibition of ABCB11 expression and disruption of the F-actin cytoskeleton. Furthermore, the observed synergistic toxicity of chlorpromazine and BA was associated with increased oxidative stress and modulation of death receptor signalling. Combined, our results demonstrate that the hepatic spheroid models presented here can be used to detect and study compounds with cholestatic liability. PMID:27759057

  20. Experiments and parametric studies on 3D metallic auxetic metamaterials with tuneable mechanical properties

    NASA Astrophysics Data System (ADS)

    Ren, Xin; Shen, Jianhu; Ghaedizadeh, Arash; Tian, Hongqi; Xie, Yi Min

    2015-09-01

    Auxetic metamaterials are synthetic materials with microstructures engineered to achieve negative Poisson’s ratios. Auxetic metamaterials are of great interest because of their unusual properties and various potential applications. However, most of the previous research has been focused on auxetic behaviour of elastomers under elastic deformation. Inspired by our recent finding of the loss of auxetic behaviour in metallic auxetic metamaterials, a systematic experimental and numerical investigation has been carried out to explore the mechanism behind this phenomenon. Using an improved methodology of generating buckling-induced auxetic metamaterials, several samples of metallic auxetic metamaterials have been fabricated using a 3D printing technique. The experiments on those samples have revealed the special features of auxetic behaviour for metallic auxetic metamaterials and proved the effectiveness of our structural modification. Parametric studies have been performed through experimentally validated finite element models to explore the auxetic performance of the designed metallic metamaterials. It is found that the auxetic performance can be tuned by the geometry of microstructures, and the strength and stiffness can be tuned by the plasticity of the base material while maintaining the auxetic performance.

  1. 3D Finite Element Study on: Bar Splinted Implants Supporting Partial Denture in the Reconstructed Mandible

    PubMed Central

    El-Anwar, Mohamed; Ghali, Rami; Aboelnagga, Mona

    2016-01-01

    AIM: This study aimed to estimate the stress patterns induced by the masticatory loads on a removable prosthesis supported and retained by bar splinted implants placed in the reconstructed mandible with two different clip materials and without clip, in the fibula-jaw bone and prosthesis using finite element analysis. METHODS: Two 3D finite element models were constructed, that models components were modeled on commercial CAD/CAM software then assembled into finite element package. Vertical loads were applied simulating the masticatory forces unilaterally in the resected site and bilaterally in the central fossa of the lower first molar as 100N (tension and compression). Analysis was based on the assumption full osseointegration between different types of bones, and between implants and fibula while fixing the top surface of the TMJ in place. RESULTS: The metallic bar connecting the three implants is insensitive to the clips material. Its supporting implants showed typical behavior with maximum stress values at the neck region. Fibula and jaw bone showed stresses within physiologic, while clips material effect seems to be very small due to its relatively small size. CONCLUSION: Switching loading force direction from tensile to compression did-not change the stresses and deformations distribution, but reversed their sign from positive to negative. PMID:27275353

  2. Photoemission studies on the 3D Dirac semiemtal state in Na3Bi

    NASA Astrophysics Data System (ADS)

    Xu, Suyang; Chang, Liu; Kushwaha, Satya K.; Sankar, Raman; Krizan, Jason W.; Belopolski, Ilya; Neupane, Madhab; Bian, Guang; Alidoust, Nasser; Chang, Tay-Rong; Jeng, Horng-Tay; Huang, Cheng-Yi; Tsai, Wei-Feng; Lin, Hsin; Shibayev, Pavel P.; Chou, Fangcheng; Cava, Robert J.; Hasan, M. Zahid

    2015-03-01

    A three-dimensional Dirac semimetal is a novel state of matter that has recently attracted interest in condensed matter physics and materials science. We present electronic structure measurements on the (100) surface of a recently discovered Dirac semimetal material Na3Bi. Our experimental data, for the first time, reveal a Lifshitz transition between the two bulk Dirac cones in the bulk band structure of Na3Bi. These results identify the first example of a band structure singularity in 3D Dirac materials. This is in contrast to its 2D analogs such as in twisted bilayer graphene or the surface states of topological crystalline insulators, which have been studied extensively. The observation of multiple bulk Dirac nodes along the rotational crystal axis away from the Kramers point also serve as a signature for the symmetry-protected nature of the Dirac semimetal state in Na3Bi as elaborated in recent theories. The work at Princeton and Princeton-led synchrotron-based ARPES measurements is supported by U.S. DOE DE-FG-02-05ER46200.

  3. 3D-QSAR studies on chromone derivatives as HIV-1 protease inhibitors

    NASA Astrophysics Data System (ADS)

    Ungwitayatorn, Jiraporn; Samee, Weerasak; Pimthon, Jutarat

    2004-02-01

    The three-dimensional quantitative structure-activity relationship (3D-QSAR) approach using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) was applied to a series of 30 chromone derivatives, a new class of HIV-1 protease inhibitors. The best predictive CoMFA model gives cross-validated r2 ( q2)=0.763, non-cross-validated r2=0.967, standard error of estimate ( S)=5.092, F=90.701. The best CoMSIA model has q2=0.707, non-cross-validated r2=0.943, S=7.018, F=51.734, included steric, electrostatic, hydrophobic, and hydrogen bond donor fields. The predictive ability of these models was validated by a set of five compounds that were not included in the training set. The calculated (predicted) and experimental inhibitory activities were well correlated. The contour maps obtained from CoMFA and CoMSIA models were in agreement with the previous docking study for this chromone series.

  4. FUN3D Grid Refinement and Adaptation Studies for the Ares Launch Vehicle

    NASA Technical Reports Server (NTRS)

    Bartels, Robert E.; Vasta, Veer; Carlson, Jan-Renee; Park, Mike; Mineck, Raymond E.

    2010-01-01

    This paper presents grid refinement and adaptation studies performed in conjunction with computational aeroelastic analyses of the Ares crew launch vehicle (CLV). The unstructured grids used in this analysis were created with GridTool and VGRID while the adaptation was performed using the Computational Fluid Dynamic (CFD) code FUN3D with a feature based adaptation software tool. GridTool was developed by ViGYAN, Inc. while the last three software suites were developed by NASA Langley Research Center. The feature based adaptation software used here operates by aligning control volumes with shock and Mach line structures and by refining/de-refining where necessary. It does not redistribute node points on the surface. This paper assesses the sensitivity of the complex flow field about a launch vehicle to grid refinement. It also assesses the potential of feature based grid adaptation to improve the accuracy of CFD analysis for a complex launch vehicle configuration. The feature based adaptation shows the potential to improve the resolution of shocks and shear layers. Further development of the capability to adapt the boundary layer and surface grids of a tetrahedral grid is required for significant improvements in modeling the flow field.

  5. Mimicking Natural Laminar to Turbulent Flow Transition: A Systematic CFD Study Using PAB3D

    NASA Technical Reports Server (NTRS)

    Pao, S. Paul; Abdol-Hamid, Khaled S.

    2005-01-01

    For applied aerodynamic computations using a general purpose Navier-Stokes code, the common practice of treating laminar to turbulent flow transition over a non-slip surface is somewhat arbitrary by either treating the entire flow as turbulent or forcing the flow to undergo transition at given trip locations in the computational domain. In this study, the possibility of using the PAB3D code, standard k-epsilon turbulence model, and the Girimaji explicit algebraic stresses model to mimic natural laminar to turbulent flow transition was explored. The sensitivity of flow transition with respect to two limiters in the standard k-epsilon turbulence model was examined using a flat plate and a 6:1 aspect ratio prolate spheroid for our computations. For the flat plate, a systematic dependence of transition Reynolds number on background turbulence intensity was found. For the prolate spheroid, the transition patterns in the three-dimensional boundary layer at different flow conditions were sensitive to the free stream turbulence viscosity limit, the reference Reynolds number and the angle of attack, but not to background turbulence intensity below a certain threshold value. The computed results showed encouraging agreements with the experimental measurements at the corresponding geometry and flow conditions.

  6. 3D structures of individual mammalian genomes studied by single-cell Hi-C.

    PubMed

    Stevens, Tim J; Lando, David; Basu, Srinjan; Atkinson, Liam P; Cao, Yang; Lee, Steven F; Leeb, Martin; Wohlfahrt, Kai J; Boucher, Wayne; O'Shaughnessy-Kirwan, Aoife; Cramard, Julie; Faure, Andre J; Ralser, Meryem; Blanco, Enrique; Morey, Lluis; Sansó, Miriam; Palayret, Matthieu G S; Lehner, Ben; Di Croce, Luciano; Wutz, Anton; Hendrich, Brian; Klenerman, Dave; Laue, Ernest D

    2017-04-06

    The folding of genomic DNA from the beads-on-a-string-like structure of nucleosomes into higher-order assemblies is crucially linked to nuclear processes. Here we calculate 3D structures of entire mammalian genomes using data from a new chromosome conformation capture procedure that allows us to first image and then process single cells. The technique enables genome folding to be examined at a scale of less than 100 kb, and chromosome structures to be validated. The structures of individual topological-associated domains and loops vary substantially from cell to cell. By contrast, A and B compartments, lamina-associated domains and active enhancers and promoters are organized in a consistent way on a genome-wide basis in every cell, suggesting that they could drive chromosome and genome folding. By studying genes regulated by pluripotency factor and nucleosome remodelling deacetylase (NuRD), we illustrate how the determination of single-cell genome structure provides a new approach for investigating biological processes.

  7. Thermocapillary bubble flow and coalescence in a rotating cylinder: A 3D study

    NASA Astrophysics Data System (ADS)

    Alhendal, Yousuf; Turan, A.; Al-mazidi, M.

    2015-12-01

    The process of thermocapillary bubbles rising in a rotating 3D cylinder in zero gravity was analysed and presented numerically with the aid of computational fluid dynamics (CFD) by means of the volume of fluid (VOF) method. Calculations were carried out to investigate in detail the effect of the rotational speed of the hosted liquid on the trajectory of both single and group bubbles driven by the Marangoni force in zero-gravity conditions. For rotational speeds from 0.25 to 2 rad/s, bubble displacement with angular motion was found to be directed between the hotter surface and the rotational axis. This is contrary to the conventional bubble flow from areas of high pressure to low pressure, radial direction, or from cold to hot regions, axial direction. The results demonstrate that for the ratio of rotational speeds to the thermocapillary bubble velocity larger than unity, the surface tension gradient is the dominant force and the bubble motion towards the hotter. On the other hand, for ratio less than 1, the bubble motion is dominated and is significantly affected by centrifugal force. As rotation speed increases, the amount of deflection increases and the Marangoni effect vanishes. The current study is novel in the sense that single- and multi-bubble motion incorporating thermocapillary forces in a rotating liquid in a zero-gravity environment has never been numerically investigated.

  8. 3D-QSAR and molecular docking studies on HIV protease inhibitors

    NASA Astrophysics Data System (ADS)

    Tong, Jianbo; Wu, Yingji; Bai, Min; Zhan, Pei

    2017-02-01

    In order to well understand the chemical-biological interactions governing their activities toward HIV protease activity, QSAR models of 34 cyclic-urea derivatives with inhibitory HIV were developed. The quantitative structure activity relationship (QSAR) model was built by using comparative molecular similarity indices analysis (CoMSIA) technique. And the best CoMSIA model has rcv2, rncv2 values of 0.586 and 0.931 for cross-validated and non-cross-validated. The predictive ability of CoMSIA model was further validated by a test set of 7 compounds, giving rpred2 value of 0.973. Docking studies were used to find the actual conformations of chemicals in active site of HIV protease, as well as the binding mode pattern to the binding site in protease enzyme. The information provided by 3D-QSAR model and molecular docking may lead to a better understanding of the structural requirements of 34 cyclic-urea derivatives and help to design potential anti-HIV protease molecules.

  9. Study of a high-resolution, 3D positioning cadmium zinc telluride detector for PET

    NASA Astrophysics Data System (ADS)

    Gu, Y.; Matteson, J. L.; Skelton, R. T.; Deal, A. C.; Stephan, E. A.; Duttweiler, F.; Gasaway, T. M.; Levin, C. S.

    2011-03-01

    This paper investigates the performance of 1 mm resolution cadmium zinc telluride (CZT) detectors for positron emission tomography (PET) capable of positioning the 3D coordinates of individual 511 keV photon interactions. The detectors comprise 40 mm × 40 mm × 5 mm monolithic CZT crystals that employ a novel cross-strip readout with interspersed steering electrodes to obtain high spatial and energy resolution. The study found a single anode FWHM energy resolution of 3.06 ± 0.39% at 511 keV throughout most of the detector volume. Improved resolution is expected with properly shielded front-end electronics. Measurements made using a collimated beam established the efficacy of the steering electrodes in facilitating enhanced charge collection across anodes, as well as a spatial resolution of 0.44 ± 0.07 mm in the direction orthogonal to the electrode planes. Finally, measurements based on coincidence electronic collimation yielded a point spread function with 0.78 ± 0.10 mm FWHM, demonstrating 1 mm spatial resolution capability transverse to the anodes—as expected from the 1 mm anode pitch. These findings indicate that the CZT-based detector concept has excellent performance and shows great promise for a high-resolution PET system.

  10. Study of a high-resolution, 3D positioning cadmium zinc telluride detector for PET.

    PubMed

    Gu, Y; Matteson, J L; Skelton, R T; Deal, A C; Stephan, E A; Duttweiler, F; Gasaway, T M; Levin, C S

    2011-03-21

    This paper investigates the performance of 1 mm resolution cadmium zinc telluride (CZT) detectors for positron emission tomography (PET) capable of positioning the 3D coordinates of individual 511 keV photon interactions. The detectors comprise 40 mm × 40 mm × 5 mm monolithic CZT crystals that employ a novel cross-strip readout with interspersed steering electrodes to obtain high spatial and energy resolution. The study found a single anode FWHM energy resolution of 3.06 ± 0.39% at 511 keV throughout most of the detector volume. Improved resolution is expected with properly shielded front-end electronics. Measurements made using a collimated beam established the efficacy of the steering electrodes in facilitating enhanced charge collection across anodes, as well as a spatial resolution of 0.44 ± 0.07 mm in the direction orthogonal to the electrode planes. Finally, measurements based on coincidence electronic collimation yielded a point spread function with 0.78 ± 0.10 mm FWHM, demonstrating 1 mm spatial resolution capability transverse to the anodes-as expected from the 1 mm anode pitch. These findings indicate that the CZT-based detector concept has excellent performance and shows great promise for a high-resolution PET system.

  11. A 3D Computational Study on the Air-Blast Atomization of a Planar Liquid Layer

    NASA Astrophysics Data System (ADS)

    Chiodi, Robert; Desjardins, Olivier

    2016-11-01

    The air-blast atomization of a planar liquid layer is a complex fluid phenomenon involving the destabilization of a low speed liquid layer by a high speed gas coflow. While progress has been made in recent years on understanding the instability of the liquid surface, it remains difficult to accurately predict using stability analysis and requires special expertise and equipment to perform thorough experiments. Simulations provide an excellent way to conduct parametric studies to determine the effect of splitter plate geometry and momentum flux ratio on the frequency and wavelengths of instability, however, they are extremely difficult due to the high density ratio and large range of length and time scales present in the flow. Using an accurate conservative level set method in conjunction with a newly reformulated reinitialization equation, we perform 3D simulations of the air-blast atomization of a planar liquid layer and compare them to experiments. We then go on to explore the role momentum flux ratio plays in the longitudinal and transverse wavelengths of instability.

  12. 3D-QSAR study of hallucinogenic phenylalkylamines by using CoMFA approach

    NASA Astrophysics Data System (ADS)

    Zhang, Zhuoyong; An, Liying; Hu, Wenxiang; Xiang, Yuhong

    2007-04-01

    The three-dimensional quantitative structure-activity relationship (3D-QSAR) has been studied on 90 hallucinogenic phenylalkylamines by the comparative molecular field analysis (CoMFA). Two conformations were compared during the modeling. Conformation I referred to the amino group close to ring position 6 and conformation II related to the amino group trans to the phenyl ring. Satisfactory results were obtained by using both conformations. There were still differences between the two models. The model based on conformation I got better statistical results than the one about conformation II. And this may suggest that conformation I be preponderant when the hallucinogenic phenylalkylamines interact with the receptor. To further confirm the predictive capability of the CoMFA model, 18 compounds with conformation I were randomly selected as a test set and the remaining ones as training set. The best CoMFA model based on the training set had a cross-validation coefficient q 2 of 0.549 at five components and non cross-validation coefficient R 2 of 0.835, the standard error of estimation was 0.219. The model showed good predictive ability in the external test with a coefficient R pre 2 of 0.611. The CoMFA coefficient contour maps suggested that both steric and electrostatic interactions play an important role. The contributions from the steric and electrostatic fields were 0.450 and 0.550, respectively.

  13. Study of a high-resolution, 3-D positioning cadmium zinc telluride detector for PET

    PubMed Central

    Gu, Y; Matteson, J L; Skelton, R T; Deal, A C; Stephan, E A; Duttweiler, F; Gasaway, T M; Levin, C S

    2011-01-01

    This paper investigates the performance of 1 mm resolution Cadmium Zinc Telluride (CZT) detectors for positron emission tomography (PET) capable of positioning the 3-D coordinates of individual 511 keV photon interactions. The detectors comprise 40 mm × 40 mm × 5 mm monolithic CZT crystals that employ a novel cross-strip readout with interspersed steering electrodes to obtain high spatial and energy resolution. The study found a single anode FWHM energy resolution of 3.06±0.39% at 511 keV throughout most the detector volume. Improved resolution is expected with properly shielded front-end electronics. Measurements made using a collimated beam established the efficacy of the steering electrodes in facilitating enhanced charge collection across anodes, as well as a spatial resolution of 0.44±0.07 mm in the direction orthogonal to the electrode planes. Finally, measurements based on coincidence electronic collimation yielded a point spread function with 0.78±0.10 mm FWHM, demonstrating 1 mm spatial resolution capability transverse to the anodes – as expected from the 1 mm anode pitch. These findings indicate that the CZT-based detector concept has excellent performance and shows great promise for a high-resolution PET system. PMID:21335649

  14. Experimental study of 3D Rayleigh-Taylor convection between miscible fluids in a porous medium

    NASA Astrophysics Data System (ADS)

    Nakanishi, Yuji; Hyodo, Akimitsu; Wang, Lei; Suekane, Tetsuya

    2016-11-01

    The natural convection of miscible fluids in porous media has applications in several fields, such as geoscience and geoengineering, and can be employed for the geological storage of CO2. In this study, we used X-ray computer tomography to visualize 3D fingering structures associated with the Rayleigh-Taylor instability between miscible fluids in a porous medium. In the early stages of the onset of the Rayleigh-Taylor instability, a fine crinkling pattern gradually appeared at the interface. As the wavelength and amplitude increased, descending fingers formed on the interface and extended vertically downward; in addition, ascending and highly symmetric fingers formed. The adjacent fingers were cylindrical in shape and coalesced to form large fingers. The fingers appearing on the interface tended to become finer with increasing Rayleigh number, which is consistent with linear perturbation theory. When the Péclet number exceeded 10, transverse dispersion increased the finger diameter and enhanced the finger coalescence, strongly impacting the decrease in finger number density. When mechanical dispersion was negligible, the finger-extension velocity and the dimensionless mass-transfer rate scaled with the characteristic velocity and the Rayleigh number with an appropriate length scale. Mechanical dispersion not only reduced the onset time but also enhanced the mass transport.

  15. Synthesis and 3D-QSAR study of 1,4-dihydropyridine derivatives as MDR cancer reverters.

    PubMed

    Radadiya, Ashish; Khedkar, Vijay; Bavishi, Abhay; Vala, Hardevsinh; Thakrar, Shailesh; Bhavsar, Dhairya; Shah, Anamik; Coutinho, Evans

    2014-03-03

    A series of symmetrical and unsymmetrical 1,4-dihydropyridines were synthesized by a rapid, single pot microwave irradiation (MWI) based protocol along with conventional approach and characterized by NMR, IR and mass spectroscopic techniques. The compounds were evaluated for their tumor cell cytotoxicity in HL-60 tumor cells. A 3D-QSAR study using CoMFA and CoMSIA was carried out to decipher the factors governing MDR reversing ability in cancer. The resulting contour maps derived by the best 3D-QSAR models provide a good insight into the molecular features relevant to the biological activity in this series of analogs. 3D contour maps as a result of 3D-QSAR were utilized to identify some novel features that can be incorporated into the 1,4-dihydropyridine framework to enhance the activity.

  16. 3D modeling of soil structure in urban groundwater areas: case studies in Kolpene, Rovaniemi, Finland

    NASA Astrophysics Data System (ADS)

    Kupila, Juho

    2015-04-01

    3D modeling of groundwater areas is an important research method in groundwater surveys. Model of geological soil structure improves the knowledge of linkage between land use planning and groundwater protection. Results can be used as base information when developing the water supply services and anticipating and performing the measures needed in case of environmental accidents. Also, collected information is utilized when creating the groundwater flow model. In Finland, structure studies have been conducted in cooperation (among others) with the municipalities and local water suppliers and with the authorities from the Centre for Economic Development, Transport and the Environment. Geological Survey of Finland carries out project "Structure studies in Kolpene groundwater area" in Rovaniemi, Finnish Lapland. Study site is located in northern Finland, in the vicinity of the city center of Rovaniemi. Extent of the area is about 13 square kilometers and there are lots of urban residential areas and other human activities. The objective of this project is to determine the geological structure of the Kolpene groundwater area so that the results can be used to estimate the validity of the present exclusion area and possible risks to the groundwater caused by the land use. Soil layers of the groundwater area are studied by means of collecting information by heavy drilling, geophysical surveying (ground penetrating radar and gravimeter measurements) and water sampling from the installed observation pipes. Also the general geological and hydrological mappings are carried out. Main results which will be produced are: 1) the model of the bedrock surface, 2) the model of the surface of the ground water and flow directions, 3) the thickness of ground water saturated soil layers and 4) location and main characteristics of the soil layers which are significant to the ground water conditions. The preparing studies have been started at the end of 2013 and the results will be

  17. Kinematic 3-D Retro-Modeling of an Orogenic Bend in the South Limón Fold-and-Thrust Belt, Eastern Costa Rica: Prediction of the Incremental Internal Strain Distribution

    NASA Astrophysics Data System (ADS)

    Brandes, Christian; Tanner, David C.; Winsemann, Jutta

    2016-10-01

    The South Limón fold-and-thrust belt, in the back-arc area of southern Costa Rica, is characterized by a 90° curvature of the strike of the thrust planes and is therefore a natural laboratory for the analysis of curved orogens. The analysis of curved fold-and-thrust belts is a challenge because of the varying structural orientations within the belt. Based on seismic reflection lines, we created a 3-D subsurface model containing three major thrust faults and three stratigraphic horizons. 3-D kinematic retro-deformation modeling was carried out to analyze the spatial evolution of the fold-and-thrust belt. The maximum amount of displacement on each of the faults is (from hinterland to foreland); thrust 1: 800 m; thrust 2: 600 m; thrust 3: 250 m. The model was restored sequentially to its pre-deformational state. The strain history of the stratigraphic horizons in the model was calculated at every step. This shows that the internal strain pattern has an abrupt change at the orogenic bend. Contractional strain occurs in the forelimbs of the hanging-wall anticlines, while a zone of dilative strain spreads from the anticline crests to the backlimbs. The modeling shows that a NNE-directed transport direction best explains the structural evolution of the bend. This would require a left-lateral strike-slip zone in the North to compensate for the movement and thereby decoupling the South Limón fold-and-thrust belt from northern Costa Rica. Therefore, our modeling supports the presence of the Trans-Isthmic fault system, at least during the Plio-Pleistocene.

  18. Retrieval of cloud microphysical parameters from INSAT-3D: a feasibility study using radiative transfer simulations

    NASA Astrophysics Data System (ADS)

    Jinya, John; Bipasha, Paul S.

    2016-05-01

    Clouds strongly modulate the Earths energy balance and its atmosphere through their interaction with the solar and terrestrial radiation. They interact with radiation in various ways like scattering, emission and absorption. By observing these changes in radiation at different wavelength, cloud properties can be estimated. Cloud properties are of utmost importance in studying different weather and climate phenomena. At present, no satellite provides cloud microphysical parameters over the Indian region with high temporal resolution. INSAT-3D imager observations in 6 spectral channels from geostationary platform offer opportunity to study continuous cloud properties over Indian region. Visible (0.65 μm) and shortwave-infrared (1.67 μm) channel radiances can be used to retrieve cloud microphysical parameters such as cloud optical thickness (COT) and cloud effective radius (CER). In this paper, we have carried out a feasibility study with the objective of cloud microphysics retrieval. For this, an inter-comparison of 15 globally available radiative transfer models (RTM) were carried out with the aim of generating a Look-up- Table (LUT). SBDART model was chosen for the simulations. The sensitivity of each spectral channel to different cloud properties was investigated. The inputs to the RT model were configured over our study region (50°S - 50°N and 20°E - 130°E) and a large number of simulations were carried out using random input vectors to generate the LUT. The determination of cloud optical thickness and cloud effective radius from spectral reflectance measurements constitutes the inverse problem and is typically solved by comparing the measured reflectances with entries in LUT and searching for the combination of COT and CER that gives the best fit. The products are available on the website www.mosdac.gov.in

  19. Study on camera calibration technique of 3D color digitization system

    NASA Astrophysics Data System (ADS)

    Sun, Yuchen; Ge, Baozhen

    2006-11-01

    3D (three-dimensional) color digitization of an object is fulfilled by light-stripe method based on laser triangle principle and direct capturing method based on the color photo of the object. With this system, information matching between 3D and color sensor and data registration of different sensors are fulfilled by a sensor calibration process. The process uses the same round filament target to calibrate all of the sensors together. The principle and procedure of the process are presented in detail. Finally, a costume model is 3D color digitized and the obtaining data sets are processed by the method discussed, the results verify the correctness and feasibility of the algorithm.

  20. Investigations and improvements of digital holographic tomography applied for 3D studies of transmissive photonics microelements

    NASA Astrophysics Data System (ADS)

    Kujawinska, Malgorzata; Jozwicka, Agata; Kozacki, Tomasz

    2008-08-01

    In order to control performance of photonics microelements it is necessary to receive 3D information about their amplitude and phase distributions. To perform this task we propose to apply tomography based on projections gather by digital holography (DH). Specifically the DH capability to register several angular views of the object during a single hologram capture is employed, which may in future shorten significantly the measurement time or even allow for tomographic analysis of dynamic media. However such a new approach brings a lot of new issues to be considered. Therefore, in this paper the method limitations, with special emphasis on holographic reconstruction process, are investigated through extensive numerical experiments with special focus on 3D refractive index distribution determination.. The main errors and means of their elimination are presented. The possibility of 3D refractive index distribution determination by means of DHT is proved numerically and experimentally.

  1. A novel 3D integrated platform for the high-resolution study of cell migration plasticity.

    PubMed

    Schneider, Julian; Bachmann, Tobias; Franco, Davide; Richner, Patrizia; Galliker, Patrick; Tiwari, Manish K; Ferrari, Aldo; Poulikakos, Dimos

    2013-08-01

    Understanding the mechanisms of interstitial cancer migration is of great scientific and medical interest. Creating 3D platforms, conducive to optical microscopy and mimicking the physical parameters (in plane and out of plane) involved in interstitial migration, is a major step forward in this direction. Here, a novel approach is used to directly print free-form, 3D micropores on basal scaffolds containing microgratings optimized for contact guidance. The platforms so formed are validated by monitoring cancer cell migration and micropore penetration with high-resolution optical microscopy. The shapes, sizes and deformability of the micropores are controllable, paving the way to decipher their role in interstitial migration.

  2. A feasibility study of a 3-D finite element solution scheme for aeroengine duct acoustics

    NASA Technical Reports Server (NTRS)

    Abrahamson, A. L.

    1980-01-01

    The advantage from development of a 3-D model of aeroengine duct acoustics is the ability to analyze axial and circumferential liner segmentation simultaneously. The feasibility of a 3-D duct acoustics model was investigated using Galerkin or least squares element formulations combined with Gaussian elimination, successive over-relaxation, or conjugate gradient solution algorithms on conventional scalar computers and on a vector machine. A least squares element formulation combined with a conjugate gradient solver on a CDC Star vector computer initially appeared to have great promise, but severe difficulties were encountered with matrix ill-conditioning. These difficulties in conditioning rendered this technique impractical for realistic problems.

  3. 3D Numerical Study of Typical CME Event: The 2010-04-03 Event

    NASA Astrophysics Data System (ADS)

    Zhou, Y.; Feng, X. S.; Zhao, X.

    2014-12-01

    The coronal mass ejection (CME) event on April 3, 2010 is the first fast CME observed by STEREO SECCHI/HI for the full Sun-Earth line. Such an event provides us a good opportunity to study the propagation and evolution of CME from the Sun up to 1 AU. In this paper, we study the time-dependent evolution and propagation of this event from the Sun to Earth using the 3D SIP-CESE MHD model. The CME is initiated by a simple spherical plasmoid model: a spheromak magnetic structure with high speed, high pressure and high plasma density plasmoid. We find that the results can successfully reproduce the observations in the STEREO A/B COR1 and COR2 field of view and generate many basic structures of the in situ measurement: such as the similar curves of the plasma density and velocity, an increase in the magnetic field magnitude, the large-scale smooth magnetic field rotation and prolonged southward IMF (a well known source of magnetic storms). The MHD model gives the shock arrival time at Earth with an error of ˜ 1.5 hours. Finally, we analyze in detail the propagation velocity, the spread angle, the trajectory of CME. The speed of the CME rapidly increases from near the Sun, then decreases due to interaction with the solar wind ambient. The spread angle of the CME quickly increases due to lateral material expansion by the pressure gradients within the realistic solar wind background, then the expansion decreases with distance and ends until a pressure equilibrium is established. We also study the CME deflection and find that the CME almost does not deflects in the latitudinal and longitudinal direction during its propagation from the Sun to 1 AU.

  4. Studies of mixed HEU-LEU-MTR cores using 3D models

    SciTech Connect

    Haenggi, P.; Lehmann, E.; Hammer, J.; Christen, R.

    1997-08-01

    Several different core loadings were assembled at the SAPHIR research reactor in Switzerland combining the available types of MTR-type fuel elements, consisting mainly of both HEU and LEU fuel. Bearing in mind the well known problems which can occur in such configurations (especially power peaking), investigations have been carried out for each new loading with a 2D neutron transport code (BOXER). The axial effects were approximated by a global buckling value and therefore the radial effects could be studied in considerably detail. Some of the results were reported at earlier RERTR meetings and were compared to those obtained by other methods and with experimental values. For the explicit study of the third dimension of the core, another code (SILWER), which has been developed in PSI for LWR power plant cores, has been selected. With the help of an adapted model for the MTR-core of SAPHIR, several important questions have been addressed. Among other aspects, the estimation of the axial contribution to the hot channel factors, the influence of the control rod position and of the Xe-poisoning on the power distribution were studied. Special attention was given to a core position where a new element was assumed placed near a empty, water filled position. The comparison of elements of low and high enrichments at this position was made in terms of the induced power peaks, with explicit consideration of axial effects. The program SILWER has proven to be applicable to MTR-cores for the investigation of axial effects. For routine use as for the support of reactor operation, this 3D code is a good supplement to the standard 2D model.

  5. Study of a viewer tracking system with multiview 3D display

    NASA Astrophysics Data System (ADS)

    Yang, Jinn-Cherng; Wu, Chang-Shuo; Hsiao, Chuan-Heng; Yang, Ming-Chieh; Liu, Wen-Chieh; Hung, Yi-Ping

    2008-02-01

    An autostereoscopic display provides users great enjoyment of stereo visualization without uncomfortable and inconvenient drawbacks of wearing stereo glasses. However, bandwidth constraints of current multi-view 3D display severely restrict the number of views that can be simultaneously displayed without degrading resolution or increasing display cost unacceptably. An alternative to multiple view presentation is that the position of observer can be measured by using viewer-tracking sensor. It is a very important module of the viewer-tracking component for fluently rendering and accurately projecting the stereo video. In order to render stereo content with respect to user's view points and to optically project the content onto the left and right eyes of the user accurately, the real-time viewer tracking technique that allows the user to move around freely when watching the autostereoscopic display is developed in this study. It comprises the face detection by using multiple eigenspaces of various lighting conditions, fast block matching for tracking four motion parameters of the user's face region. The Edge Orientation Histogram (EOH) on Real AdaBoost to improve the performance of original AdaBoost algorithm is also applied in this study. The AdaBoost algorithm using Haar feature in OpenCV library developed by Intel to detect human face and enhance the accuracy performance with rotating image. The frame rate of viewer tracking process can achieve up to 15 Hz. Since performance of the viewer tracking autostereoscopic display is still influenced under variant environmental conditions, the accuracy, robustness and efficiency of the viewer-tracking system are evaluated in this study.

  6. Molecular interaction study of flavonoid derivative 3d with human serum albumin using multispectroscopic and molecular modeling approach.

    PubMed

    Wei, Juntong; Jin, Feng; Wu, Qin; Jiang, Yuyang; Gao, Dan; Liu, Hongxia

    2014-08-01

    Human serum albumin (HSA) has been developed as a model protein to study drug-protein interaction. In the present work, the interaction between our synthesized flavonoid derivative 3d (possessing potent antitumor activity against HepG2 cells) and HSA was investigated using fluorescence spectroscopy, circular dichroism spectroscopy, UV-vis spectroscopy and molecular modeling approach. Fluorescence spectroscopy showed that the fluorescence of HSA can be quenched remarkably by 3d under physiological condition with a slight shift of maximum fluorescence emission bands from 360nm to 363nm. Calculated results from Stern-Volmer equation and modified Stern-Volmer equation indicated that the fluorescence was quenched by static quenching processing with association constant 5.26±0.04×10(4)L mol(-1) at 298K. After comprehensive consideration of the free energy change ΔG, enthalpy change ΔH and entropy change ΔS, electrostatic interactions were confirmed as the main factor that participate in stabilizing the 3d-HSA complex. Both dichroism spectroscopy and UV-vis spectroscopy indicated conformational change of HSA after binding to 3d. Moreover, the structure of HSA was loosened and the percentage of α-helix decreased with increasing concentration of 3d. Molecular modeling results demonstrated that 3d could bind to HSA well into subdomain IIA, which is related to its capability of deposition and delivery. Three cation-π interactions and three hydrogen bonds occurred between 3d and amino acid residuals ARG218, ARG222 and LYS199. In conclusion, flavonoid derivative 3d can bind to HSA with noncovalent bond in a relatively stable way, so it can be delivered by HSA in a circulatory system.

  7. A 3-D reconstruction solution to current density imaging based on acoustoelectric effect by deconvolution: a simulation study.

    PubMed

    Yang, Renhuan; Li, Xu; Song, Aiguo; He, Bin; Yan, Ruqiang

    2013-05-01

    Hybrid imaging modality combining ultrasound scanning and electrical current density imaging through the acoustoelectric (AE) effect may potentially provide solutions to imaging electrical activities and properties of biological tissues with high spatial resolution. In this study, a 3-D reconstruction solution to ultrasound current source density imaging (UCSDI) by means of Wiener deconvolution is proposed and evaluated through computer simulations. As compared to previous 2-D UCSDI problem, in a 3-D volume conductor with broadly distributed current density field, the AE signal becomes a 3-D convolution between the electric field and the acoustic field, and effective 3-D reconstruction algorithm has not been developed so far. In the proposed method, a 3-D ultrasound scanning is performed while the corresponding AE signals are collected from multiple electrode pairs attached on the surface of the imaging object. From the collected AE signals, the acoustic field and electric field were first decoupled by Wiener deconvolution. Then, the current density distribution was reconstructed by inverse projection. Our simulations using artificial current fields in homogeneous phantoms suggest that the proposed method is feasible and robust against noise. It is also shown that using the proposed method, it is feasible to reconstruct 3-D current density distribution in an inhomogeneous conductive medium.

  8. Novel 3D magnetic resonance elastography for the noninvasive diagnosis of advanced fibrosis in NAFLD: A prospective study

    PubMed Central

    Loomba, Rohit; Cui, Jeffrey; Wolfson, Tanya; Haufe, William; Hooker, Jonathan; Szeverenyi, Nikolaus; Ang, Brandon; Bhatt, Archana; Wang, Kang; Aryafar, Hamed; Behling, Cindy; Valasek, Mark A.; Lin, Grace Y.; Gamst, Anthony; Brenner, David A.; Yin, Meng; Glaser, Kevin J.; Ehman, Richard L.; Sirlin, Claude B.

    2016-01-01

    Objective Recent studies show two-dimensional (2D)-MRE is accurate in diagnosing advanced fibrosis (stages 3 and 4) in nonalcoholic fatty liver disease (NAFLD) patients. 3D-MRE is a more advanced version of the technology that can image shear-wave fields in 3D of the entire liver. The aim of this study was to prospectively compare the diagnostic accuracy of 3D-MRE and 2D-MRE for diagnosing advanced fibrosis in patients with biopsy-proven NAFLD. Design This cross-sectional analysis of a prospective study included 100 consecutive patients (56% women) with biopsy-proven NAFLD who also underwent MRE. Area under the receiver operating characteristic (AUROC) ana3lysis was performed to assess the accuracy of 2D and 3D-MRE in diagnosing advanced fibrosis. Results The mean (±sd) of age and BMI was 50.2 (±13.6) yrs and 32.1 (±5.0) kg/m2, respectively. The AUROC for diagnosing advanced fibrosis was 0.981 for 3D-MRE at 40 Hz, 0.927 for 3D-MRE at 60 Hz (standard shear-wave frequency), and 0.921 for 2D-MRE at 60 Hz (standard shear-wave frequency). At a threshold of 2.43 kPa, 3D-MRE at 40 Hz had sensitivity 1.0, specificity 0.94, positive predictive value 0.72, and negative predictive value 1.0 for diagnosing advanced fibrosis. 3D-MRE at 40 Hz had significantly higher AUROC (p<0.05) than 2D-MRE at 60 Hz for diagnosing advanced fibrosis. Conclusion Utilizing a prospective study design, we demonstrate that 3D MRE at 40 Hz has the highest diagnostic accuracy in diagnosing NAFLD advanced fibrosis. Both 2D and 3D-MRE at 60 Hz, the standard shear-wave frequency, are also highly accurate in diagnosing NAFLD advanced fibrosis. PMID:27002798

  9. Compressive Behavior of 3D Woven Composite Stiffened Panels: Experimental and Numerical Study

    NASA Astrophysics Data System (ADS)

    Zhou, Guangming; Pan, Ruqin; Li, Chao; Cai, Deng'an; Wang, Xiaopei

    2016-10-01

    The structural behavior and damage propagation of 3D woven composite stiffened panels with different woven patterns under axial-compression are here investigated. The panel is 2.5D interlock woven composites (2.5DIWC), while the straight-stiffeners are 3D woven orthogonal composites (3DWOC). They are coupled together with the Z-fibers from the stiffener passing straight thought the thickness of the panel. A "T-shape" model, in which the fiber bundle structure and resin matrix are drawn out to simulate the real situation of the connection area, is established to predict elastic constants and strength of the connection region. Based on Hashin failure criterion, a progressive damage model is carried out to simulate the compressive behavior of the stiffened panel. The 3D woven composite stiffened panels are manufactured using RTM process and then tested. A good agreement between experimental results and numerical predicted values for the compressive failure load is obtained. From initial damage to final collapse, the panel and stiffeners will not separate each other in the connection region. The main failure mode of 3D woven composite stiffened panels is compressive failure of fiber near the loading end corner.

  10. Children's Writing Goes 3D: A Case Study of One Primary School's Journey into Multimodal Authoring

    ERIC Educational Resources Information Center

    Thomas, Angela

    2012-01-01

    This paper draws from research conducted as part of an Australian Research Council funded Linkage Project "Teaching effective 3D authoring in the middle years: multimedia grammatical design and multimedia authoring pedagogy", which is a collaboration between the University of New England, the University of Tasmania and the Australian…

  11. 3D homogeneity study in PMMA layers using a Fourier domain OCT system

    NASA Astrophysics Data System (ADS)

    Briones-R., Manuel de J.; Torre-Ibarra, Manuel H. De La; Tavera, Cesar G.; Luna H., Juan M.; Mendoza-Santoyo, Fernando

    2016-11-01

    Micro-metallic particles embedded in polymers are now widely used in several industrial applications in order to modify the mechanical properties of the bulk. A uniform distribution of these particles inside the polymers is highly desired for instance, when a biological backscattering is simulated or a bio-framework is designed. A 3D Fourier domain optical coherence tomography system to detect the polymer's internal homogeneity is proposed. This optical system has a 2D camera sensor array that records a fringe pattern used to reconstruct with a single shot the tomographic image of the sample. The system gathers the full 3D tomographic and optical phase information during a controlled deformation by means of a motion linear stage. This stage avoids the use of expensive tilting stages, which in addition are commonly controlled by piezo drivers. As proof of principle, a series of different deformations were proposed to detect the uniform or non-uniform internal deposition of copper micro particles. The results are presented as images coming from the 3D tomographic micro reconstruction of the samples, and the 3D optical phase information that identifies the in-homogeneity regions within the Poly methyl methacrylate (PMMA) volume.

  12. Online Stereo 3D Simulation in Studying the Spherical Pendulum in Conservative Force Field

    ERIC Educational Resources Information Center

    Zabunov, Svetoslav S.

    2013-01-01

    The current paper aims at presenting a modern e-learning method and tool that is utilized in teaching physics in the universities. An online stereo 3D simulation is used for e-learning mechanics and specifically the teaching of spherical pendulum as part of the General Physics course for students in the universities. This approach was realized on…

  13. 3-D Flow Field Diagnostics and Validation Studies using Stereoscopic Tracking Velocimetry

    NASA Technical Reports Server (NTRS)

    Cha, Soyoung Stephen; Ramachandran, Narayanan; Whitaker, Ann F. (Technical Monitor)

    2002-01-01

    The measurement of 3-D three-component velocity fields is of great importance in both ground and space experiments for understanding materials processing and fluid physics. Here, we present the investigation results of stereoscopic tracking velocimetry (STV) for measuring 3-D velocity fields. The effort includes diagnostic technology development, experimental velocity measurement, and comparison with analytical and numerical computation. The advantages of STV stems from the system simplicity for building compact hardware and in software efficiency for continual near-real-time process monitoring. It also has illumination flexibility for observing volumetric flow fields from arbitrary directions. STV is based on stereoscopic CCD observations of particles seeded in a flow. Neural networks are used for data analysis. The developed diagnostic tool is tested with a simple directional solidification apparatus using Succinonitrile. The 3-D velocity field in the liquid phase is measured and compared with results from detailed numerical computations. Our theoretical, numerical, and experimental effort has shown STV to be a viable candidate for reliably quantifying the 3-D flow field in materials processing and fluids experiments.

  14. 3D QSAR studies, pharmacophore modeling and virtual screening on a series of steroidal aromatase inhibitors.

    PubMed

    Xie, Huiding; Qiu, Kaixiong; Xie, Xiaoguang

    2014-11-14

    Aromatase inhibitors are the most important targets in treatment of estrogen-dependent cancers. In order to search for potent steroidal aromatase inhibitors (SAIs) with lower side effects and overcome cellular resistance, comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) were performed on a series of SAIs to build 3D QSAR models. The reliable and predictive CoMFA and CoMSIA models were obtained with statistical results (CoMFA: q² = 0.636, r²(ncv) = 0.988, r²(pred) = 0.658; CoMSIA: q² = 0.843, r²(ncv) = 0.989, r²(pred) = 0.601). This 3D QSAR approach provides significant insights that can be used to develop novel and potent SAIs. In addition, Genetic algorithm with linear assignment of hypermolecular alignment of database (GALAHAD) was used to derive 3D pharmacophore models. The selected pharmacophore model contains two acceptor atoms and four hydrophobic centers, which was used as a 3D query for virtual screening against NCI2000 database. Six hit compounds were obtained and their biological activities were further predicted by the CoMFA and CoMSIA models, which are expected to design potent and novel SAIs.

  15. Sensitivity study of 3-D modeling for multi-D inversion of surface NMR

    NASA Astrophysics Data System (ADS)

    Warsa, Grandis, Hendra

    2012-06-01

    Geophysical field method of surface nuclear magnetic resonance (SNMR) allows a direct determination of hydrogeological parameters of the subsurface. The amplitude of the SNMR signal is directly linked to the amount of mobile water. The relaxation behaviour of the signal correlates with pore sizes and hydraulic conductivities of an aquifer. For improving capability and reliability of SNMR method we have presented a forward modeling scheme of 3-D water content and decay time structures that can be used for multi-D interpretation. Currently SNMR is carried out mainly with a 1-D working scheme using coinciding loops. For each sounding point using a coincident circular loop antenna, the amplitudes and decay times of the SNMR signal are the product of a three dimensional distribution of the water content and decay time in the subsurface and their sensitivity to the receiver. The antenna is moved at the surface and the SNMR relaxation signal are plotted as a function of the pulse moment and sounding point. The errors might be very large by neglecting the 2-D or even 3-D geometry of the structures which have to be considered in the analysis and inversion in the future. The results show that the 3-D modeling is reliable and flexible to be integrated into the 2-D/3-D inversion scheme for inverting surface NMR data to recover a multi-D distribution of water content and decay time of an aquifer.

  16. Micro-CT images reconstruction and 3D visualization for small animal studying

    NASA Astrophysics Data System (ADS)

    Gong, Hui; Liu, Qian; Zhong, Aijun; Ju, Shan; Fang, Quan; Fang, Zheng

    2005-01-01

    A small-animal x-ray micro computed tomography (micro-CT) system has been constructed to screen laboratory small animals and organs. The micro-CT system consists of dual fiber-optic taper-coupled CCD detectors with a field-of-view of 25x50 mm2, a microfocus x-ray source, a rotational subject holder. For accurate localization of rotation center, coincidence between the axis of rotation and centre of image was studied by calibration with a polymethylmethacrylate cylinder. Feldkamp"s filtered back-projection cone-beam algorithm is adopted for three-dimensional reconstruction on account of the effective corn-beam angle is 5.67° of the micro-CT system. 200x1024x1024 matrix data of micro-CT is obtained with the magnification of 1.77 and pixel size of 31x31μm2. In our reconstruction software, output image size of micro-CT slices data, magnification factor and rotation sample degree can be modified in the condition of different computational efficiency and reconstruction region. The reconstructed image matrix data is processed and visualization by Visualization Toolkit (VTK). Data parallelism of VTK is performed in surface rendering of reconstructed data in order to improve computing speed. Computing time of processing a 512x512x512 matrix datasets is about 1/20 compared with serial program when 30 CPU is used. The voxel size is 54x54x108 μm3. The reconstruction and 3-D visualization images of laboratory rat ear are presented.

  17. 3-D habitat suitability of jack mackerel Trachurus murphyi in the Southeastern Pacific, a comprehensive study

    NASA Astrophysics Data System (ADS)

    Bertrand, Arnaud; Habasque, Jérémie; Hattab, Tarek; Hintzen, Niels T.; Oliveros-Ramos, Ricardo; Gutiérrez, Mariano; Demarcq, Hervé; Gerlotto, François

    2016-08-01

    South Pacific jack mackerel, Trachurus murphyi, has an ocean-scale distribution, from the South American coastline to New Zealand and Tasmania. This fish, captured by Humans since the Holocene, is nowadays heavily exploited and its population has decreased substantially since the mid-1990s. The uncertainty associated to jack mackerel population structure currently hampers management. Several hypotheses have been proposed from a single population up to several discrete populations. Still no definitive answer was given. Determining how environmental conditions drive jack mackerel distribution can provide insights on its population structure. To do so, here we performed in three steps. First, we used satellite data to develop a statistical model of jack mackerel horizontal habitat suitability. Model predictions based on interaction between temperature and chlorophyll-a match the observed jack mackerel distribution, even during extreme El Niño event. Second, we studied the impact of oxygen and show that jack mackerel distribution and abundance is correlated to oxygen over a wide variety of scales and avoid low oxygen areas and periods. Third, on the basis of the above we built a conceptual 3D model of jack mackerel habitat in the Southeastern Pacific. We reveal the presence of a low suitable habitat along the Chilean and Peruvian coast, figuratively presenting a closed door caused by a gap in the horizontal habitat at ∼19-22°S and a shallow oxycline off south-centre Peru. This kind of situation likely occurs on a seasonal basis, in austral summer but also at longer temporal scales. A lack of exchanges at some periods/seasons partially isolate jack mackerel distributed off Peru. On the other hand the continuity in the habitat during most of the year explains why exchanges occur. We conclude that the more likely population structure for jack mackerel is a pelagic metapopulation.

  18. Characterization of double modified internal gate pixel by 3D simulation study

    NASA Astrophysics Data System (ADS)

    Aurola, A.; Marochkin, V.; Tuuva, T.

    2015-01-01

    We have developed a novel detector concept based on Modified Internal Gate Field Effect Transistor (MIGFET) wherein a buried Modified Internal Gate (MIG) is implanted underneath a channel of a FET. In between the MIG and the channel of the FET there is a depleted semiconductor material forming a potential barrier between charges in the channel and similar type signal charges located in the MIG. The signal charges in the MIG have a measurable effect on the conductance of the channel. In this paper a double MIGFET pixel is investigated comprising two MIGFETs. By transferring the signal charges between the two MIGs Non-Destructive Correlated Double Sampling Readout (NDCDSR) is enabled. The proposed MIG radiation detector suits particularly well for low-light-level imaging, X-ray spectroscopy, as well as synchrotron and X-ray Free Electron Laser (XFEL) facilities. The reason for the excellent X-ray detection performance stems from the fact that interface related issues can be considerably mitigated since interface generated dark noise can be completely avoided and interface generated 1/f and Random Telegraph Signal (RTS) noise can be considerably reduced due to a deep buried channel readout configuration. Electrical parameters of the double MIGFET pixel have been evaluated by 3D TCAD simulation study. Simulation results show the absence of interface generated dark noise, significantly reduced interface generated 1/f and RTS noise, well performing NDCDSR operation, and blooming protection due to an inherent vertical anti-blooming structure. In addition, the backside illuminated thick fully depleted pixel design provides a homogeneous radiation entry window, low crosstalk due to lack of diffusion, and good quantum efficiency for low energy X-rays and NIR light. These facts result in excellent Signal-to-Noise Ratio (SNR) and very low crosstalk enabling thus excellent X-ray energy and spatial resolution. The simulation demonstrates the charge to current conversion gain for

  19. Toxicity Profile of IMRT Vs. 3D-CRT in Head and Neck Cancer: A Retrospective Study

    PubMed Central

    Tallari, Ramanjis; Malviya, Anupam

    2016-01-01

    Introduction Role of radiotherapy in comprehensive management of head and neck cancer for achieving tumour control and organ preservation is now well established and radiotherapy is routinely used in adjuvant setting after surgery, concurrently with chemotherapy or targeted agents and for palliation. Development of linear accelerator with Multileaf Collimator (MLC) have revolutionized radiation delivery techniques, allowing conformal and Intensity Modulated Radiotherapy (IMRT) to deliver highly conformal sculpted radiation dose to a very complex structure with improved sparing of adjoining critical structures like salivary glands, spinal cord, eyes, brainstem and larynx amounting to better therapeutic gain. Aim This retrospective study was to compare toxicity profile of IMRT with Three Dimensional Conformal Radiotherapy (3D CRT) in head and neck cancer. Materials and Methods Total of 80 patients from January 2013 to July 2015 with proven head and neck cancer who underwent radiotherapy on linac 2300 C/D machine were included in the study, IMRT group and 3D-CRT group comprised of 40 patients each. We have searched patient’s radiotherapy details in record section of our institute and observations were noted down. Patients received 70Gy/35 fractions, Monday to Friday as radical treatment and 60 Gy/30 fractions as adjuvant treatment were included. Results The 3D-CRT group demonstrated significantly more acute toxic effects compared with the IMRT group in our analysis. Acute Grade 3 or greater toxic effects to the skin occurred in 5 of 40 (12.5%), patients in the 3D-CRT group compared with 3 of 40 (7.5%) patients in the IMRT group. Acute Grade 3 or greater toxic effects to the mucous membranes occurred in 23 of 40 (57.5%) patients in the 3D-CRT group and only 16 of 40 (40%) patients in the IMRT group. Statistically significant dysphagia developed in 34 of 40 (85%), patients in 3D-CRT group compared with 23 of 40 (57.5%) patients in IMRT group, while statistically

  20. Reaching and grasping behavior in Macaca fascicularis: a kinematic study.

    PubMed

    Sartori, Luisa; Camperio Ciani, Andrea; Bulgheroni, Maria; Castiello, Umberto

    2013-01-01

    The prehensile hand is one of the major traits distinguishing primates from other mammal species. All primates, in fact, are able to grasp an object and hold it in part or entirely using a single hand. Although there is a wealth of behavioral data regarding grasping movements in humans and apes, there is relatively little material on macaques, the animal model often used to investigate neuronal mechanisms responsible for grip control in humans. To date, evidence regarding free-ranging macaques is confined to observational data, while quantitative reports describe studies carried out in laboratory settings or in captivity. The purpose of the present study was to provide the first kinematic descriptions of basic grip behavior with regard to precision and power grips in free-ranging macaque monkeys. Video footage of those animals grasping objects was analyzed frame-by-frame using digitalization techniques. The results revealed that the two types of grips considered are each characterized by specific kinematic signatures. It was also found that hand kinematics was scaled depending on the type of grasp needing to be adopted and the intrinsic properties of the object to be grasped. In accordance with data concerning humans, these findings indicate that the intrinsic features of an object affect the planning and control of reach-to-grasp movements even in free-ranging macaques. The data presented here take research in the field of comparative reach-to-grasp kinematics in human and non-human primates another step forward as they are based on precise measurements of spontaneous grasping movements by animals living/acting in their natural environment.

  1. Fundamental Study on Applicability of Powder-Based 3D Printer for Physical Modeling in Rock Mechanics

    NASA Astrophysics Data System (ADS)

    Fereshtenejad, Sayedalireza; Song, Jae-Joon

    2016-06-01

    Applications of 3D printing technology become more widespread in many research fields because of its rapid development and valuable capabilities. In rock mechanics and mining engineering, this technology has the potential to become a useful tool that might help implement a number of research studies previously considered impractical. Most commercial 3D printers cannot print prototypes with mechanical properties that match precisely those of natural rock samples. Therefore, some additional enhancements are required for 3D printers to be effectively utilized for rock mechanics applications. In this study, we printed and studied specimens using a powder-based commercial ZPrinter® 450 with ZP® 150 powder and Zb® 63 binder used as raw materials. The specimens printed by this 3D printer exhibited relatively low strength and ductile behavior, implying that it needs further improvements. Hence, we focused on several ways to determine the best combination of printing options and post-processing including the effects of the printing direction, printing layer thickness, binder saturation level, and heating process on the uniaxial compressive strength (UCS) and stress-strain behavior of the printed samples. The suggested procedures have demonstrated their effectiveness by obtaining the printed samples that behave similarly to the natural rocks with low UCS. Although our optimization methods were particularly successful, further improvements are required to expand 3D printer application in the area of rock mechanics.

  2. 3D electro-thermal Monte Carlo study of transport in confined silicon devices

    NASA Astrophysics Data System (ADS)

    Mohamed, Mohamed Y.

    The simultaneous explosion of portable microelectronics devices and the rapid shrinking of microprocessor size have provided a tremendous motivation to scientists and engineers to continue the down-scaling of these devices. For several decades, innovations have allowed components such as transistors to be physically reduced in size, allowing the famous Moore's law to hold true. As these transistors approach the atomic scale, however, further reduction becomes less probable and practical. As new technologies overcome these limitations, they face new, unexpected problems, including the ability to accurately simulate and predict the behavior of these devices, and to manage the heat they generate. This work uses a 3D Monte Carlo (MC) simulator to investigate the electro-thermal behavior of quasi-one-dimensional electron gas (1DEG) multigate MOSFETs. In order to study these highly confined architectures, the inclusion of quantum correction becomes essential. To better capture the influence of carrier confinement, the electrostatically quantum-corrected full-band MC model has the added feature of being able to incorporate subband scattering. The scattering rate selection introduces quantum correction into carrier movement. In addition to the quantum effects, scaling introduces thermal management issues due to the surge in power dissipation. Solving these problems will continue to bring improvements in battery life, performance, and size constraints of future devices. We have coupled our electron transport Monte Carlo simulation to Aksamija's phonon transport so that we may accurately and efficiently study carrier transport, heat generation, and other effects at the transistor level. This coupling utilizes anharmonic phonon decay and temperature dependent scattering rates. One immediate advantage of our coupled electro-thermal Monte Carlo simulator is its ability to provide an accurate description of the spatial variation of self-heating and its effect on non

  3. The estimation of 3D SAR distributions in the human head from mobile phone compliance testing data for epidemiological studies.

    PubMed

    Wake, Kanako; Varsier, Nadège; Watanabe, Soichi; Taki, Masao; Wiart, Joe; Mann, Simon; Deltour, Isabelle; Cardis, Elisabeth

    2009-10-07

    A worldwide epidemiological study called 'INTERPHONE' has been conducted to estimate the hypothetical relationship between brain tumors and mobile phone use. In this study, we proposed a method to estimate 3D distribution of the specific absorption rate (SAR) in the human head due to mobile phone use to provide the exposure gradient for epidemiological studies. 3D SAR distributions due to exposure to an electromagnetic field from mobile phones are estimated from mobile phone compliance testing data for actual devices. The data for compliance testing are measured only on the surface in the region near the device and in a small 3D region around the maximum on the surface in a homogeneous phantom with a specific shape. The method includes an interpolation/extrapolation and a head shape conversion. With the interpolation/extrapolation, SAR distributions in the whole head are estimated from the limited measured data. 3D SAR distributions in the numerical head models, where the tumor location is identified in the epidemiological studies, are obtained from measured SAR data with the head shape conversion by projection. Validation of the proposed method was performed experimentally and numerically. It was confirmed that the proposed method provided good estimation of 3D SAR distribution in the head, especially in the brain, which is the tissue of major interest in epidemiological studies. We conclude that it is possible to estimate 3D SAR distributions in a realistic head model from the data obtained by compliance testing measurements to provide a measure for the exposure gradient in specific locations of the brain for the purpose of exposure assessment in epidemiological studies. The proposed method has been used in several studies in the INTERPHONE.

  4. Population Estimation Using a 3D City Model: A Multi-Scale Country-Wide Study in the Netherlands

    PubMed Central

    Arroyo Ohori, Ken; Ledoux, Hugo; Peters, Ravi; Stoter, Jantien

    2016-01-01

    The remote estimation of a region’s population has for decades been a key application of geographic information science in demography. Most studies have used 2D data (maps, satellite imagery) to estimate population avoiding field surveys and questionnaires. As the availability of semantic 3D city models is constantly increasing, we investigate to what extent they can be used for the same purpose. Based on the assumption that housing space is a proxy for the number of its residents, we use two methods to estimate the population with 3D city models in two directions: (1) disaggregation (areal interpolation) to estimate the population of small administrative entities (e.g. neighbourhoods) from that of larger ones (e.g. municipalities); and (2) a statistical modelling approach to estimate the population of large entities from a sample composed of their smaller ones (e.g. one acquired by a government register). Starting from a complete Dutch census dataset at the neighbourhood level and a 3D model of all 9.9 million buildings in the Netherlands, we compare the population estimates obtained by both methods with the actual population as reported in the census, and use it to evaluate the quality that can be achieved by estimations at different administrative levels. We also analyse how the volume-based estimation enabled by 3D city models fares in comparison to 2D methods using building footprints and floor areas, as well as how it is affected by different levels of semantic detail in a 3D city model. We conclude that 3D city models are useful for estimations of large areas (e.g. for a country), and that the 3D approach has clear advantages over the 2D approach. PMID:27254151

  5. An integrated system for 3D hip joint reconstruction from 2D X-rays: a preliminary validation study.

    PubMed

    Schumann, Steffen; Liu, Li; Tannast, Moritz; Bergmann, Mathias; Nolte, Lutz-P; Zheng, Guoyan

    2013-10-01

    The acquisition of conventional X-ray radiographs remains the standard imaging procedure for the diagnosis of hip-related problems. However, recent studies demonstrated the benefit of using three-dimensional (3D) surface models in the clinical routine. 3D surface models of the hip joint are useful for assessing the dynamic range of motion in order to identify possible pathologies such as femoroacetabular impingement. In this paper, we present an integrated system which consists of X-ray radiograph calibration and subsequent 2D/3D hip joint reconstruction for diagnosis and planning of hip-related problems. A mobile phantom with two different sizes of fiducials was developed for X-ray radiograph calibration, which can be robustly detected within the images. On the basis of the calibrated X-ray images, a 3D reconstruction method of the acetabulum was developed and applied together with existing techniques to reconstruct a 3D surface model of the hip joint. X-ray radiographs of dry cadaveric hip bones and one cadaveric specimen with soft tissue were used to prove the robustness of the developed fiducial detection algorithm. Computed tomography scans of the cadaveric bones were used to validate the accuracy of the integrated system. The fiducial detection sensitivity was in the same range for both sizes of fiducials. While the detection sensitivity was 97.96% for the large fiducials, it was 97.62% for the small fiducials. The acetabulum and the proximal femur were reconstructed with a mean surface distance error of 1.06 and 1.01 mm, respectively. The results for fiducial detection sensitivity and 3D surface reconstruction demonstrated the capability of the integrated system for 3D hip joint reconstruction from 2D calibrated X-ray radiographs.

  6. 220GHz wideband 3D imaging radar for concealed object detection technology development and phenomenology studies

    NASA Astrophysics Data System (ADS)

    Robertson, Duncan A.; Macfarlane, David G.; Bryllert, Tomas

    2016-05-01

    We present a 220 GHz 3D imaging `Pathfinder' radar developed within the EU FP7 project CONSORTIS (Concealed Object Stand-Off Real-Time Imaging for Security) which has been built to address two objectives: (i) to de-risk the radar hardware development and (ii) to enable the collection of phenomenology data with ~1 cm3 volumetric resolution. The radar combines a DDS-based chirp generator and self-mixing multiplier technology to achieve a 30 GHz bandwidth chirp with such high linearity that the raw point response is close to ideal and only requires minor nonlinearity compensation. The single transceiver is focused with a 30 cm lens mounted on a gimbal to acquire 3D volumetric images of static test targets and materials.

  7. Studies of the Vector Field in Shallow Water and in the Presence of 3-D Variability

    DTIC Science & Technology

    2015-09-30

    developed to represent data that would be measured on an acoustic vector sensor . Basic processing schemes were then evaluated to determine if such...data could yield information on the directional nature of the ambient noise. In addition, data collection events were conducted in FY15 with...acoustic vector sensors to provide some test data sets. This allowed some processing strings to be developed. RESULTS 3-D MMPE Modeling: In FY15

  8. [Optimized study technic in meniscopathies by NMR tomographic 3D imaging at 1.5 tesla].

    PubMed

    Skalej, M; Klose, U; Küper, K

    1988-02-01

    Traumatic and degenerative changes in the meniscus can be demonstrated well by MRT, but the small size and complex anatomical structure of the menisci present practical problems. A correct understanding is only possible by images in several planes and good resolution, making the examination a lengthy procedure. A technique is therefore described using 3-D images and reconstruction of high-resolution films, which allows rapid examination of the menisci in optimal planes.

  9. A Radiative Transfer Case Study for 3-d cloud effects in the UV

    NASA Astrophysics Data System (ADS)

    Meerkötter, Ralf; Degünther, Markus

    Satellite UV mapping is usually based on the independent pixel approximation (IPA) which neglects horizontal photon transport between adjacent columns. Horizontal inhomogeneity of cloud fields therefore causes uncertainties in the derived UV radiation fields. While these effects are small for large pixel satellites, the broken-cloud errors increase as the pixel size decreases. By comparing results of 1-d and 3-d UV radiative transfer calculations for three selected cloud scenes that cover a rather broad range of cloud inhomogeneity the main 3-d cloud effects on the atmospheric UV transmission are identified and quantified in their order of magnitude. With respect to the different spatial resolutions of satellite instruments it is further shown how 3-d cloud effects average out with increasing spatial scale. It turns out that locally the IPA cause maximum uncertainties up to ±100% for a spatial resolution of about 1 × 1 km² (e.g., AVHRR), they are reduced to ±10% for a resolution of about 15 × 15 km² and below 5% for a resolution greater than 30 km (e.g., TOMS).

  10. Topographical surveys: Classical method versus 3D laser scanning. Case study - An application in civil engineering

    NASA Astrophysics Data System (ADS)

    Grigoraş, I.-R.; Covăsnianu, A.; Pleşu, G.; Benedict, B.

    2009-04-01

    The paper describes an experiment which took place in Iasi town, Romania, consisted in two different topographical survey techniques applied for one and the same objective placed in a block within the city (western part) - a thermal power station. The purpose was to compare those methods and to determine which one is proper to be used in this domain in terms of fastness, optimization and speed of data processing. First technique applied for our survey was the classical one, with a total station. Using the CAD technique, we obtained a final product (a dwg file) and a list of coordinates (a text file). The second method, which we focused our attention more, was the measurement with a very precise 3D laser scanstation, also very suitable in archeology. The data obtained were processed with special software. Result was a 3D model of the thermal power plant composed of measurable cloud point data. Finally, analyzing the advantages and disadvantages of each method, we came to the conclusion that the 3D laser scanning which we used matches well the application, in this case civil engineering, but the future of accepting and implementing this technique is in the hands of Romanian authorities.

  11. Multielectron coincidence study of the double Auger decay of 3d-ionized krypton

    SciTech Connect

    Andersson, E.; Hedin, L.; Rubensson, J.-E.; Karlsson, L.; Feifel, R.; Fritzsche, S.; Linusson, P.; Eland, J. H. D.

    2010-10-15

    Multielectron coincidence data for triple ionization of krypton have been recorded above the 3d ionization threshold at two photon energies (140 and 150 eV). Three principal transition pathways have been observed, two involving double Auger transitions from Kr{sup +}, and one involving single Auger transitions from Kr{sup 2+} created by direct single-photon double ionization. The decay of the 3d{sup 9} {sup 2}D{sub 5/2,3/2} states in Kr{sup +} has been analyzed in some detail and is found to be strongly dominated by cascade processes where two electrons with well-defined energies are emitted. The decay paths leading to the 4s{sup 2}4p{sup 3} {sup 4}S, {sup 2}D, and {sup 2}P states of Kr{sup 3+} are analyzed and energies of seven intermediate states in Kr{sup 2+} are given. A preliminary investigation of the decay paths from Kr{sup +} 3d{sup 9}4p{sup 5}nl shake-up states has also been carried out.

  12. Systolic and diastolic assessment by 3D-ASM segmentation of gated-SPECT Studies: a comparison with MRI

    NASA Astrophysics Data System (ADS)

    Tobon-Gomez, C.; Bijnens, B. H.; Huguet, M.; Sukno, F.; Moragas, G.; Frangi, A. F.

    2009-02-01

    Gated single photon emission tomography (gSPECT) is a well-established technique used routinely in clinical practice. It can be employed to evaluate global left ventricular (LV) function of a patient. The purpose of this study is to assess LV systolic and diastolic function from gSPECT datasets in comparison with cardiac magnetic resonance imaging (CMR) measurements. This is achieved by applying our recently implemented 3D active shape model (3D-ASM) segmentation approach for gSPECT studies. This methodology allows for generation of 3D LV meshes for all cardiac phases, providing volume time curves and filling rate curves. Both systolic and diastolic functional parameters can be derived from these curves for an assessment of patient condition even at early stages of LV dysfunction. Agreement of functional parameters, with respect to CMR measurements, were analyzed by means of Bland-Altman plots. The analysis included subjects presenting either LV hypertrophy, dilation or myocardial infarction.

  13. A 3-D numerical study of pinhole diffraction to predict the accuracy of EUV point diffraction interferometry

    SciTech Connect

    Goldberg, K.A. |; Tejnil, E.; Bokor, J. |

    1995-12-01

    A 3-D electromagnetic field simulation is used to model the propagation of extreme ultraviolet (EUV), 13-nm, light through sub-1500 {Angstrom} dia pinholes in a highly absorptive medium. Deviations of the diffracted wavefront phase from an ideal sphere are studied within 0.1 numerical aperture, to predict the accuracy of EUV point diffraction interferometersused in at-wavelength testing of nearly diffraction-limited EUV optical systems. Aberration magnitudes are studied for various 3-D pinhole models, including cylindrical and conical pinhole bores.

  14. Study of a vibrating fiber probing system for 3-D micro-structures: performance improvement

    NASA Astrophysics Data System (ADS)

    Murakami, H.; Katsuki, A.; Sajima, T.; Suematsu, T.

    2014-09-01

    This paper presents a system for measuring 3D micro-structures that uses an optical fiber probe equipped with a piezo element that causes the probe to vibrate. The optical fiber probe consists of a stylus shaft with a diameter of 3 µm and a glass ball with a diameter of 5 µm attached to the tip. The stylus is vibrated in a circular motion in a single plane. The vibrator mechanism is introduced to prevent adhesion of the stylus tip to the surface being measured. This adhesion, which adversely affects the accuracy and time of the measurement, is caused by intermolecular, electrostatic, and liquid bridge forces. The measuring principle involves monitoring the vibrational amplitude of the stylus shaft that is required to prevent the adhesion of the stylus tip to the surface being measured, this amplitude being measured optically. In our previous report (Murakami et al 2012 Key Eng. Mater. 523-524 907-12), we found that the stylus shaft actually moves in an elliptical motion when it is set to describe a circular motion in the X-Y plane. Therefore, when a measurement is taken, it is necessary to adjust the motion of the piezoelectric tube to compensate for the difference between the diameter of the perfect circle and the actual elliptical motion of the stylus shaft displacement. In this study, the stylus characteristics were examined and the motion of the stylus shaft was then corrected to attain the desired circular motion. Next, the expansion of the measuring area by using a line laser was investigated. Finally, an experiment involving the measurement of a micro-hole was performed to demonstrate the practicality of the vibrating fiber probe. As a result, it was shown that the displacement between the diameter of the perfect circle and the actual elliptical motion of the stylus tip was about 0.034 µm after compensation. In addition, it was confirmed that the measurement area can be expanded by using an optical slit, but the standard deviation of the

  15. Full 3D Microwave Tomography enhanced GPR surveys: a case study

    NASA Astrophysics Data System (ADS)

    Catapano, Ilaria; Soldovieri, Francesco; Affinito, Antonio; Hugenschmidt, Johannes

    2014-05-01

    Ground Penetrating Radar (GPR) systems are well assessed non-invasive diagnostic tools capable of providing high resolution images of the inner structure of the probed spatial region. Owing to this capability, GPR systems are nowadays more and more considered in the frame of civil engineering surveys since they may give information on constructive details as well as on the aging and risk factors affecting the healthiness of an infrastructure. In this frame, accurate, reliable and easily interpretable images of the probed scenarios are mandatory in order to support the management of maintenance works and assure the safety of structures. Such a requirement motivates the use of different and sophisticated data processing approaches in order to compare more than one image of the same scene, thus improving the reliability and objectiveness of the GPR survey results. Among GPR data processing procedures, Microwave Tomography approaches based on the Born approximation face the imaging as the solution of a linear inverse problem, which is solved by using the Truncated Singular Value Decomposition as a regularized inversion scheme [1]. So far, an approach exploiting a 2D scalar model of the scattering phenomenon have been adopted to process GPR data gathered along a single scan. In this case, 3D images are obtained by interpolating 2D reconstructions (this is referred commonly as pseudo 3D imaging). Such an imaging approach have provided valuable results in several real cases dealing with not only surveys for civil engineering but also archeological prospection, subservice monitoring, security surveys and so on [1-4]. These encouraging results have motivated the development of a full 3D Microwave Tomography approach capable of accounting for the vectorial nature of the wave propagation. The reconstruction capabilities of this novel approach have been assessed mainly against experimental data collected in laboratory controlled conditions. The obtained results corroborate

  16. The ultrasound brain helmet: early human feasibility study of multiple simultaneous 3D scans of cerebral vasculature

    NASA Astrophysics Data System (ADS)

    Lindsey, Brooks D.; Ivancevich, Nikolas M.; Whitman, John; Light, Edward; Fronheiser, Matthew; Nicoletto, Heather A.; Laskowitz, Daniel T.; Smith, Stephen W.

    2009-02-01

    We describe early stage experiments to test the feasibility of an ultrasound brain helmet to produce multiple simultaneous real-time 3D scans of the cerebral vasculature from temporal and suboccipital acoustic windows of the skull. The transducer hardware and software of the Volumetrics Medical Imaging real-time 3D scanner were modified to support dual 2.5 MHz matrix arrays of 256 transmit elements and 128 receive elements which produce two simultaneous 64° pyramidal scans. The real-time display format consists of two coronal B-mode images merged into a 128° sector, two simultaneous parasagittal images merged into a 128° × 64° C-mode plane, and a simultaneous 64° axial image. Real-time 3D color Doppler images acquired in initial clinical studies after contrast injection demonstrate flow in several representative blood vessels. An offline Doppler rendering of data from two transducers simultaneously scanning via the temporal windows provides an early visualization of the flow in vessels on both sides of the brain. The long-term goal is to produce real-time 3D ultrasound images of the cerebral vasculature from a portable unit capable of internet transmission, thus enabling interactive 3D imaging, remote diagnosis and earlier therapeutic intervention. We are motivated by the urgency for rapid diagnosis of stroke due to the short time window of effective therapeutic intervention.

  17. The Effect of 3D Visual Simulator on Children’s Visual Acuity - A Pilot Study Comparing Two Different Modalities

    PubMed Central

    Ide, Takeshi; Ishikawa, Mariko; Tsubota, Kazuo; Miyao, Masaru

    2013-01-01

    Purpose : To evaluate the efficacy of two non-surgical interventions of vision improvement in children. Methods : A prospective, randomized, pilot study to compare fogging method and the use of head mounted 3D display. Subjects were children, between 5 to 15 years old, with normal best corrected visual acuity (BCVA) and up to -3D myopia. Subjects played a video game as near point work, and received one of the two methods of treatments. Measurements of uncorrected far visual acuity (UCVA), refraction with autorefractometer, and subjective accommodative amplitude were taken 3 times, at the baseline, after the near work, and after the treatment. Results : Both methods applied after near work, improved UCVA. Head mounted 3D display group showed significant improvement in UCVA and resulted in better UCVA than baseline. Fogging group showed improvement in subjective accommodative amplitude. While 3D display group did not show change in the refraction, fogging group’s myopic refraction showed significant increase indicating the eyes showed myopic change of eyes after near work and treatment. Discussion : Despite our lack of clear knowledge in the mechanisms, both methods improved UCVA after the treatments. The improvement in UCVA was not correlated to measured refraction values. Conclusion : UCVA after near work can be improved by repeating near and distant accommodation by fogging and 3D image viewing, although at the different degrees. Further investigation on mechanisms of improvements and their clinical significance are warranted. PMID:24222810

  18. The impact of active versus passive use of 3D technology: a study of dental students at Wuhan University, China.

    PubMed

    Qi, Shengcai; Yan, Yanhong; Li, Rong; Hu, Jian

    2013-11-01

    A variety of computer-based 3D applications are becoming regular tools for dental students for self-learning. This study investigated the learning effectiveness of junior dental students in passively versus actively controlling the 3D virtual scenes of implant dentistry. Participants were randomized into three groups and were exposed to three designs of educational materials: traditional 2D webpages (2D); active-controlling 3D webpages (A3); and passive-controlling 3D webpages (P3). After reviewing the webpages, the participants were asked to complete a posttest to assess the relative quality of information acquisition. Their responses were compared and analyzed. The results indicated that the P3 group received the highest score of 26.4±3.1 on the post-test, significantly better than the A3 group, which had the worst performance with a score of 20.3±4.0. The 2D group received a score of 24.2±4.6. There was a significant correlation between the scores on a mental rotations test and the subjects' performance on the posttest (p<0.001). A serious disadvantage of active control was indicated for individuals with low spatial ability. In 3D virtual reality assisted self-learning, passive control produces higher learning effects compared to active control. Too much active control may generate significantly negative impacts on students, especially for individuals with low spatial ability.

  19. Quantitative moment study and coupling of 4 f rare earth and 3 d metal by transmitted electrons

    NASA Astrophysics Data System (ADS)

    Fu, X.; Warot-Fonrose, B.; Arras, R.; Dumesnil, K.; Serin, V.

    2016-10-01

    We report a simultaneous investigation of 3 d and 4 f magnetic moments by exploring the Fe -L2 ,3 and Dy -M4 ,5 electron energy-loss edges of a DyF e2/YF e2 superlattice using the energy-loss magnetic chiral dichroism (EMCD) technique. Specific EMCD sum rules for M4 ,5 edges were established and carefully applied to the dichroic signal at Dy -M4 ,5 edges, giving an orbital to the effective spin moment ratio of 5.1 ±1.8 . With dynamic diffraction effects considered, the opposite signs of Fe -L3 and Dy -M5 dichroic peaks unambiguously indicate the antiparallel alignment of net Fe 3 d and Dy 4 f moments. The EMCD technique is shown to be an effective tool to locally characterize the 4 f moment of rare earth elements and study 3 d -4 f moment coupling.

  20. A feasibility study of hand kinematics for EVA analysis using magnetic resonance imaging

    NASA Technical Reports Server (NTRS)

    Dickenson, Rueben D.; Lorenz, Christine H.; Peterson, Steven W.; Strauss, Alvin M.; Main, John A.

    1992-01-01

    A new method of analyzing the kinematics of joint motion is developed. Magnetic Resonance Imaging (MRI) offers several distinct advantages. Past methods of studying anatomic joint motion have usually centered on four approaches. These methods are x-ray projection, goniometric linkage analysis, sonic digitization, and landmark measurement of photogrammetry. Of these four, only x-ray is applicable for in vivo studies. The remaining three methods utilize other types of projections of inter-joint measurements, which can cause various types of error. MRI offers accuracy in measurement due to its tomographic nature (as opposed to projection) without the problems associated with x-ray dosage. Once the data acquisition of MR images was complete, the images were processed using a 3D volume rendering workstation. The metacarpalphalangeal (MCP) joint of the left index finger was selected and reconstructed into a three-dimensional graphic display. From the reconstructed volumetric images, measurements of the angles of movement of the applicable bones were obtained and processed by analyzing the screw motion of the MCP joint. Landmark positions were chosen at distinctive locations of the joint at fixed image threshold intensity levels to ensure repeatability. The primarily two dimensional planar motion of this joint was then studied using a method of constructing coordinate systems using three (or more) points. A transformation matrix based on a world coordinate system described the location and orientation of a local target coordinate system. Future research involving volume rendering of MRI data focusing on the internal kinematics of the hand's individual ligaments, cartilage, tendons, etc. will follow. Its findings will show the applicability of MRI to joint kinematics for gaining further knowledge of the hand-glove (power assisted) design for extravehicular activity (EVA).

  1. Micro 3D printing using a digital projector and its application in the study of soft materials mechanics.

    PubMed

    Lee, Howon; Fang, Nicholas X

    2012-11-27

    Buckling is a classical topic in mechanics. While buckling has long been studied as one of the major structural failure modes(1), it has recently drawn new attention as a unique mechanism for pattern transformation. Nature is full of such examples where a wealth of exotic patterns are formed through mechanical instability(2-5). Inspired by this elegant mechanism, many studies have demonstrated creation and transformation of patterns using soft materials such as elastomers and hydrogels(6-11). Swelling gels are of particular interest because they can spontaneously trigger mechanical instability to create various patterns without the need of external force(6-10). Recently, we have reported demonstration of full control over buckling pattern of micro-scaled tubular gels using projection micro-stereolithography (PμSL), a three-dimensional (3D) manufacturing technology capable of rapidly converting computer generated 3D models into physical objects at high resolution(12,13). Here we present a simple method to build up a simplified PμSL system using a commercially available digital data projector to study swelling-induced buckling instability for controlled pattern transformation. A simple desktop 3D printer is built using an off-the-shelf digital data projector and simple optical components such as a convex lens and a mirror(14). Cross-sectional images extracted from a 3D solid model is projected on the photosensitive resin surface in sequence, polymerizing liquid resin into a desired 3D solid structure in a layer-by-layer fashion. Even with this simple configuration and easy process, arbitrary 3D objects can be readily fabricated with sub-100 μm resolution. This desktop 3D printer holds potential in the study of soft material mechanics by offering a great opportunity to explore various 3D geometries. We use this system to fabricate tubular shaped hydrogel structure with different dimensions. Fixed on the bottom to the substrate, the tubular gel develops

  2. A faster method for 3D/2D medical image registration—a simulation study

    NASA Astrophysics Data System (ADS)

    Birkfellner, Wolfgang; Wirth, Joachim; Burgstaller, Wolfgang; Baumann, Bernard; Staedele, Harald; Hammer, Beat; Claudius Gellrich, Niels; Jacob, Augustinus Ludwig; Regazzoni, Pietro; Messmer, Peter

    2003-08-01

    3D/2D patient-to-computed-tomography (CT) registration is a method to determine a transformation that maps two coordinate systems by comparing a projection image rendered from CT to a real projection image. Iterative variation of the CT's position between rendering steps finally leads to exact registration. Applications include exact patient positioning in radiation therapy, calibration of surgical robots, and pose estimation in computer-aided surgery. One of the problems associated with 3D/2D registration is the fact that finding a registration includes solving a minimization problem in six degrees of freedom (dof) in motion. This results in considerable time requirements since for each iteration step at least one volume rendering has to be computed. We show that by choosing an appropriate world coordinate system and by applying a 2D/2D registration method in each iteration step, the number of iterations can be grossly reduced from n6 to n5. Here, n is the number of discrete variations around a given coordinate. Depending on the configuration of the optimization algorithm, this reduces the total number of iterations necessary to at least 1/3 of it's original value. The method was implemented and extensively tested on simulated x-ray images of a tibia, a pelvis and a skull base. When using one projective image and a discrete full parameter space search for solving the optimization problem, average accuracy was found to be 1.0 +/- 0.6(°) and 4.1 +/- 1.9 (mm) for a registration in six parameters, and 1.0 +/- 0.7(°) and 4.2 +/- 1.6 (mm) when using the 5 + 1 dof method described in this paper. Time requirements were reduced by a factor 3.1. We conclude that this hardware-independent optimization of 3D/2D registration is a step towards increasing the acceptance of this promising method for a wide number of clinical applications.

  3. Detecting falls with 3D range camera in ambient assisted living applications: a preliminary study.

    PubMed

    Leone, Alessandro; Diraco, Giovanni; Siciliano, Pietro

    2011-07-01

    In recent years several world-wide ambient assisted living (AAL) programs have been activated in order to improve the quality of life of older people, and to strengthen the industrial base through the use of information and communication technologies. An important issue is extending the time that older people can live in their home environment, by increasing their autonomy and helping them to carry out activities of daily living (ADLs). Research in the automatic detection of falls has received a lot of attention, with the object of enhancing safety, emergency response and independence of the elderly, at the same time comparing the social and economic costs related to fall accidents. In this work, an algorithmic framework to detect falls by using a 3D time-of-flight vision technology is presented. The proposed system presented complementary working requirements with respect to traditional worn and non-worn fall-detection devices. The vision system used a state-of-the-art 3D range camera for elderly movement measurement and detection of critical events, such as falls. The depth images provided by the active sensor allowed reliable segmentation and tracking of elderly movements, by using well-established imaging methods. Moreover, the range camera provided 3D metric information in all illumination conditions (even night vision), allowing the overcoming of some typical limitations of passive vision (shadows, camouflage, occlusions, brightness fluctuations, perspective ambiguity). A self-calibration algorithm guarantees different setup mountings of the range camera by non-technical users. A large dataset of simulated fall events and ADLs in real dwellings was collected and the proposed fall-detection system demonstrated high performance in terms of sensitivity and specificity.

  4. A faster method for 3D/2D medical image registration--a simulation study.

    PubMed

    Birkfellner, Wolfgang; Wirth, Joachim; Burgstaller, Wolfgang; Baumann, Bernard; Staedele, Harald; Hammer, Beat; Gellrich, Niels Claudius; Jacob, Augustinus Ludwig; Regazzoni, Pietro; Messmer, Peter

    2003-08-21

    3D/2D patient-to-computed-tomography (CT) registration is a method to determine a transformation that maps two coordinate systems by comparing a projection image rendered from CT to a real projection image. Iterative variation of the CT's position between rendering steps finally leads to exact registration. Applications include exact patient positioning in radiation therapy, calibration of surgical robots, and pose estimation in computer-aided surgery. One of the problems associated with 3D/2D registration is the fact that finding a registration includes solving a minimization problem in six degrees of freedom (dof) in motion. This results in considerable time requirements since for each iteration step at least one volume rendering has to be computed. We show that by choosing an appropriate world coordinate system and by applying a 2D/2D registration method in each iteration step, the number of iterations can be grossly reduced from n6 to n5. Here, n is the number of discrete variations around a given coordinate. Depending on the configuration of the optimization algorithm, this reduces the total number of iterations necessary to at least 1/3 of it's original value. The method was implemented and extensively tested on simulated x-ray images of a tibia, a pelvis and a skull base. When using one projective image and a discrete full parameter space search for solving the optimization problem, average accuracy was found to be 1.0 +/- 0.6(degrees) and 4.1 +/- 1.9 (mm) for a registration in six parameters, and 1.0 +/- 0.7(degrees) and 4.2 +/- 1.6 (mm) when using the 5 + 1 dof method described in this paper. Time requirements were reduced by a factor 3.1. We conclude that this hardware-independent optimization of 3D/2D registration is a step towards increasing the acceptance of this promising method for a wide number of clinical applications.

  5. Swimming Behavior of Pseudomonas aeruginosa Studied by Holographic 3D Tracking

    PubMed Central

    Vater, Svenja M.; Weiße, Sebastian; Maleschlijski, Stojan; Lotz, Carmen; Koschitzki, Florian; Schwartz, Thomas; Obst, Ursula; Rosenhahn, Axel

    2014-01-01

    Holographic 3D tracking was applied to record and analyze the swimming behavior of Pseudomonas aeruginosa. The obtained trajectories allow to qualitatively and quantitatively analyze the free swimming behavior of the bacterium. This can be classified into five distinct swimming patterns. In addition to the previously reported smooth and oscillatory swimming motions, three additional patterns are distinguished. We show that Pseudomonas aeruginosa performs helical movements which were so far only described for larger microorganisms. Occurrence of the swimming patterns was determined and transitions between the patterns were analyzed. PMID:24498187

  6. Dislocation kinematics: a molecular dynamics study in Cu

    NASA Astrophysics Data System (ADS)

    Oren, E.; Yahel, E.; Makov, G.

    2017-02-01

    The kinematics and kinetics of edge and screw dislocations in FCC materials were studied by molecular dynamics, with Cu as a case study. It was found that with increasing stress screw dislocations enter into the transonic regime continuously and that they remain stable up to a velocity of about 2.2 km s-1. Edge dislocations are limited by the transverse sound velocity at low stresses and discontinuously cross into the transonic regime at higher stresses. For sufficiently long edge dislocations, the subsonic-transonic transition is initiated by an athermal nucleation process. Finally, an expression for the velocity dependence of the dislocation mobility was derived.

  7. Bioavailable atmospheric phosphorous supply to the global ocean: a 3-D global modeling study

    NASA Astrophysics Data System (ADS)

    Myriokefalitakis, Stelios; Nenes, Athanasios; Baker, Alex R.; Mihalopoulos, Nikolaos; Kanakidou, Maria

    2016-12-01

    The atmospheric cycle of phosphorus (P) is parameterized here in a state-of-the-art global 3-D chemistry transport model, taking into account primary emissions of total P (TP) and soluble P (DP) associated with mineral dust, combustion particles from natural and anthropogenic sources, bioaerosols, sea spray and volcanic aerosols. For the present day, global TP emissions are calculated to be roughly 1.33 Tg-P yr-1, with the mineral sources contributing more than 80 % to these emissions. The P solubilization from mineral dust under acidic atmospheric conditions is also parameterized in the model and is calculated to contribute about one-third (0.14 Tg-P yr-1) of the global DP atmospheric source. To our knowledge, a unique aspect of our global study is the explicit modeling of the evolution of phosphorus speciation in the atmosphere. The simulated present-day global annual DP deposition flux is 0.45 Tg-P yr-1 (about 40 % over oceans), showing a strong spatial and temporal variability. Present-day simulations of atmospheric P aerosol concentrations and deposition fluxes are satisfactory compared with available observations, indicating however an underestimate of about 70 % on current knowledge of the sources that drive the P atmospheric cycle. Sensitivity simulations using preindustrial (year 1850) anthropogenic and biomass burning emission scenarios showed a present-day increase of 75 % in the P solubilization flux from mineral dust, i.e., the rate at which P is converted into soluble forms, compared to preindustrial times, due to increasing atmospheric acidity over the last 150 years. Future reductions in air pollutants due to the implementation of air-quality regulations are expected to decrease the P solubilization flux from mineral dust by about 30 % in the year 2100 compared to the present day. Considering, however, that all the P contained in bioaerosols is readily available for uptake by marine organisms, and also accounting for all other DP sources, a total

  8. Identifying the Functional Flexion-extension Axis of the Knee: An In-Vivo Kinematics Study

    PubMed Central

    Yin, Li; Chen, Kaining; Guo, Lin; Cheng, Liangjun; Wang, Fuyou; Yang, Liu

    2015-01-01

    Purpose This study aimed to calculate the flexion-extension axis (FEA) of the knee through in-vivo knee kinematics data, and then compare it with two major anatomical axes of the femoral condyles: the transepicondylar axis (TEA) defined by connecting the medial sulcus and lateral prominence, and the cylinder axis (CA) defined by connecting the centers of posterior condyles. Methods The knee kinematics data of 20 healthy subjects were acquired under weight-bearing condition using bi-planar x-ray imaging and 3D-2D registration techniques. By tracking the vertical coordinate change of all points on the surface of femur during knee flexion, the FEA was determined as the line connecting the points with the least vertical shift in the medial and lateral condyles respectively. Angular deviation and distance among the TEA, CA and FEA were measured. Results The TEA-FEA angular deviation was significantly larger than that of the CA-FEA in 3D and transverse plane (3.45° vs. 1.98°, p < 0.001; 2.72° vs. 1.19°, p = 0.002), but not in the coronal plane (1.61° vs. 0.83°, p = 0.076). The TEA-FEA distance was significantly greater than that of the CA-FEA in the medial side (6.7 mm vs. 1.9 mm, p < 0.001), but not in the lateral side (3.2 mm vs. 2.0 mm, p = 0.16). Conclusion The CA is closer to the FEA compared with the TEA; it can better serve as an anatomical surrogate for the functional knee axis. PMID:26039711

  9. Assessment of different 3D culture systems to study tumor phenotype and chemosensitivity in pancreatic ductal adenocarcinoma.

    PubMed

    Zeeberg, Katrine; Cardone, Rosa Angela; Greco, Maria Raffaella; Saccomano, Mara; Nøhr-Nielsen, Asbjørn; Alves, Frauke; Pedersen, Stine Falsig; Reshkin, Stephan Joel

    2016-07-01

    Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease with a very poor prognosis, due to the influence of the tumor stroma, which promotes tumor growth, early invasion and chemoradiation resistance. Efforts to develop models for identifying novel anticancer therapeutic compounds have been hampered by the limited ability of in vitro models to mimic these in vivo tumor-stroma interactions. This has led to the development of various three-dimensional (3D) culture platforms recapitulating the in vivo tumor-stroma crosstalk and designed to better understand basic cancer processes and screen drug action. However, a consensus for different experimental 3D platforms is still missing in PDAC. We compared four PDAC cell lines of different malignancy grown in 2D monolayers to three of the more commonly used 3D techniques (ultralow adhesion concave microwells, Matrigel inclusion and organotypic systems) and to tumors derived from their orthotopic implantation in mice. In these 3D platforms, we observed that cells grow with very different tumor morphologies and the organotypic setting most closely resembles the tumor cytoarchitecture obtained by orthotopically implanting the four cell lines in mice. We then analyzed the molecular and cellular responses of one of these cell lines to epidermal growth factor receptor (EGFR) stimulation with EGF and inhibition with erlotinib and found that only in the 3D platforms, and especially the organotypic, cells: i) responded to EGF by changing the expression of signalling components underlying cell-stroma crosstalk and tissue architecture, growth, invasion and drug resistance (E-cadherin, EGFR, ezrin, β1 integrin, NHERF1 and HIF-1α) similar to those reported in vivo; ii) had stimulated growth and increased erlotinib sensitivity in response to EGF, more faithfully mimicking their known in vivo behaviour. Altogether, these results, indicate the organotypic as the most relevant physiological 3D system to study the

  10. Random Dopant Threshold Voltage Fluctuations in 50 nm Epitaxial Channel MOSFETs: A 3D 'Atomoc' Simulation Study

    NASA Technical Reports Server (NTRS)

    Asenov, Asen

    2000-01-01

    3D 'atomistic' simulations are used to study random dopant related threshold voltage fluctuations in 50 nm MOSFETs. Comparisons are made between conventionally doped transistors and transistors with thin epitaxial silicon layers on heavily doped silicon. Issues related to both the optimum threshold voltage control and the suppression of the threshold voltage dispersion are addressed.

  11. 3D silicon microdosimetry and RBE study using 12C ion of different energies

    NASA Astrophysics Data System (ADS)

    Tran, L. T.; Chartier, L.; Bolst, D.; Prokopovich, D.; Guatelli, S.; Petasecca, M.; Lerch, M.; Reinhard, M.; Perevertaylo, V.; Jackson, M.; Matsufuji, N.; Hinde, D.; Dasgupta, M.; Stuchbery, A.; Rosenfeld, A. B.

    2017-02-01

    This paper presents a new version of the 3D mesa “bridge” microdosimeter comprised of an array of 4248 silicon cells fabricated on 10 µm thick silicon-on-insulator substrate. This microdosimeter has been designed to overcome limitations existing in previous generation silicon microdosimeters and it provides well-defined sensitive volumes and high spatial resolution. The charge collection characteristics of the new 3D mesa microdosimeter were investigated using the ANSTO heavy ion microprobe, utilizing 5.5 MeV He2+ ions. Measurement of microdosimetric quantities allowed for the determination of the Relative Biological Effectiveness of 290 MeV/u and 350 MeV/u 12C heavy ion therapy beams at the Heavy Ion Medical Accelerator in Chiba (HIMAC), Japan. The microdosimetric RBE obtained showed good agreement with the tissue-equivalent proportional counter. Utilizing the high spatial resolution of the SOI microdosimeter, the LET spectra for 70 MeV 12C+6 ions, like those present at the distal edge of 290 and 350 MeV/u beams, were obtained as the ions passed through thin layers of polyethylene film. This microdosimeter can provide useful information about the lineal energy transfer (LET) spectra downstream of the protective layers used for shielding of electronic devices for single event upset prediction.

  12. Study of the thermal properties of filaments for 3D printing

    NASA Astrophysics Data System (ADS)

    Trhlíková, Lucie; Zmeskal, Oldrich; Psencik, Petr; Florian, Pavel

    2016-07-01

    Various materials are used for 3D printing, most commonly Acrylonitrile butadiene styrene (ABS), Polylactic acid (PLA), Polyethylene (PET) and Polypropylene (PP). These materials differ mainly in their melting point, which significantly influences the properties of the final products. Filaments are melted in the print head during the printing process. The temperature range is from 150 °C to 250 °C depending on the technology used. The optimum temperature for the cooling substrate on which printing is carried out is chosen so as to ensure uniform cooling and deformation. It generally varies between (40 - 100) °C. From the above it is clear that both temperatures can significantly affect the properties of the printed 3D object. It is therefore important to determine the thermal parameters (thermal conductivity, specific heat and thermal diffusivity) of the materials used across the entire range of temperatures. For evaluating the properties of different types of PLA materials, the step transient method was used, which allows determination of all required parameters using a fractal heat transfer model.

  13. Concentric gel system to study the biophysical role of matrix microenvironment on 3D cell migration.

    PubMed

    Kurniawan, Nicholas Agung; Chaudhuri, Parthiv Kant; Lim, Chwee Teck

    2015-04-03

    The ability of cells to migrate is crucial in a wide variety of cell functions throughout life from embryonic development and wound healing to tumor and cancer metastasis. Despite intense research efforts, the basic biochemical and biophysical principles of cell migration are still not fully understood, especially in the physiologically relevant three-dimensional (3D) microenvironments. Here, we describe an in vitro assay designed to allow quantitative examination of 3D cell migration behaviors. The method exploits the cell's mechanosensing ability and propensity to migrate into previously unoccupied extracellular matrix (ECM). We use the invasion of highly invasive breast cancer cells, MDA-MB-231, in collagen gels as a model system. The spread of cell population and the migration dynamics of individual cells over weeks of culture can be monitored using live-cell imaging and analyzed to extract spatiotemporally-resolved data. Furthermore, the method is easily adaptable for diverse extracellular matrices, thus offering a simple yet powerful way to investigate the role of biophysical factors in the microenvironment on cell migration.

  14. Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

    PubMed Central

    Kurniawan, Nicholas Agung; Chaudhuri, Parthiv Kant; Lim, Chwee Teck

    2015-01-01

    The ability of cells to migrate is crucial in a wide variety of cell functions throughout life from embryonic development and wound healing to tumor and cancer metastasis. Despite intense research efforts, the basic biochemical and biophysical principles of cell migration are still not fully understood, especially in the physiologically relevant three-dimensional (3D) microenvironments. Here, we describe an in vitro assay designed to allow quantitative examination of 3D cell migration behaviors. The method exploits the cell’s mechanosensing ability and propensity to migrate into previously unoccupied extracellular matrix (ECM). We use the invasion of highly invasive breast cancer cells, MDA-MB-231, in collagen gels as a model system. The spread of cell population and the migration dynamics of individual cells over weeks of culture can be monitored using live-cell imaging and analyzed to extract spatiotemporally-resolved data. Furthermore, the method is easily adaptable for diverse extracellular matrices, thus offering a simple yet powerful way to investigate the role of biophysical factors in the microenvironment on cell migration. PMID:25867104

  15. Euro3D Science Conference

    NASA Astrophysics Data System (ADS)

    Walsh, J. R.

    2004-02-01

    The Euro3D RTN is an EU funded Research Training Network to foster the exploitation of 3D spectroscopy in Europe. 3D spectroscopy is a general term for spectroscopy of an area of the sky and derives its name from its two spatial + one spectral dimensions. There are an increasing number of instruments which use integral field devices to achieve spectroscopy of an area of the sky, either using lens arrays, optical fibres or image slicers, to pack spectra of multiple pixels on the sky (``spaxels'') onto a 2D detector. On account of the large volume of data and the special methods required to reduce and analyse 3D data, there are only a few centres of expertise and these are mostly involved with instrument developments. There is a perceived lack of expertise in 3D spectroscopy spread though the astronomical community and its use in the armoury of the observational astronomer is viewed as being highly specialised. For precisely this reason the Euro3D RTN was proposed to train young researchers in this area and develop user tools to widen the experience with this particular type of data in Europe. The Euro3D RTN is coordinated by Martin M. Roth (Astrophysikalisches Institut Potsdam) and has been running since July 2002. The first Euro3D science conference was held in Cambridge, UK from 22 to 23 May 2003. The main emphasis of the conference was, in keeping with the RTN, to expose the work of the young post-docs who are funded by the RTN. In addition the team members from the eleven European institutes involved in Euro3D also presented instrumental and observational developments. The conference was organized by Andy Bunker and held at the Institute of Astronomy. There were over thirty participants and 26 talks covered the whole range of application of 3D techniques. The science ranged from Galactic planetary nebulae and globular clusters to kinematics of nearby galaxies out to objects at high redshift. Several talks were devoted to reporting recent observations with newly

  16. Optimization of PET activation studies based on the SNR measured in the 3-D Hoffman brain phantom.

    PubMed

    Li, H H; Votaw, J R

    1998-08-01

    This work investigates the noise properties of O-15 water PET images in an attempt to increase the sensitivity of activation studies. A method for computing the amount of noise within a region of interest (ROI) from the uncertainty in the raw data was implemented for three-dimensional (3-D) positron emission tomography (PET). The method was used to study the signal-to-noise ratio (SNR) of regions-of-interest (ROI's) inside a 3-D Hoffman brain phantom. Saturation occurs at an activity concentration of 2.2 mCi/l which corresponds to a 75-mCi O-15 water injection into a normal person of average weight. This establishes the upper limit for injections for human brain studies using 3-D PET on the Siemens ECAT 921 EXACT scanner. Data from human brain activation studies on four normal volunteers using two-dimensional (2-D) PET were analyzed. The biological variation was found to be 5% in 1-ml ROI's. The variance for a complete activation study was calculated, for a variety of protocols, by combining the Poisson noise propagated from the raw data in the phantom experiments with the biological variation. A protocol that is predicted to maximize the SNR in dual-condition activation experiments while remaining below the radiation safety limit is: ten scans with 45 mCi per injection. The data should not be corrected for random or scatter events since they do not help in the identification of activation sites while they do add noise to the image. Due to the lower noise level of 3-D PET, the threshold for detecting a true change in activity concentration is 10%-20% lower than 2-D PET. Because of this, a 3-D activation experiment using the Siemens 921 scanner requires fewer subjects for equal statistical power.

  17. Social intentions in Parkinson's disease patients: A kinematic study.

    PubMed

    Straulino, Elisa; Scaravilli, Tomaso; Castiello, Umberto

    2015-09-01

    Dysfunction of the dopaminergic system leads to motor, cognitive and motivational symptoms in brain disorders such as Parkinson's disease (PD). Moreover, the dopaminergic system plays an important role in social interactions. The dopaminergic input to the basal ganglia (BG) thought to integrate social cues during the planning and execution of voluntary movements remains, however, largely unexplored. Since PD provides a model to assess this function in humans, our study aimed to investigate the effects of social intentions on actions in non-demented PDpatients receiving dopamine replacement therapy (Levodopa = l-Dopa) and in neurologically healthy control participants. Patients' ability to modulate motor patterning depending on the intention motivating the action to be performed was evaluated both in "on" (with l-Dopa) and "off" (without l-Dopa) states. Participants were instructed to reach for and to grasp an object; they were then told to hand it to another person (social condition) or to place it on a concave frame (individual condition). A 'passive-observer' condition, which was similar to the 'individual' condition except for the presence of an onlooker who simply observed the scene, was also assessed to exclude the possibility that differences might be due to the presence of another person. Movement kinematics were recorded using a three-dimensional motion analysis system. Study results demonstrated that the controls and the PD patients in an 'on' state adopted different kinematic patterning for the 'social' and the 'individual' conditions; the PD patients in the 'off' state, instead, were unable to kinematically differentiate between the two conditions. These results suggest that l-Dopa treatment has positive effects on translating social intentions into specific motor patterns in PD patients.

  18. Bootstrapping 3D fermions

    DOE PAGES

    Iliesiu, Luca; Kos, Filip; Poland, David; ...

    2016-03-17

    We study the conformal bootstrap for a 4-point function of fermions <ψψψψ> in 3D. We first introduce an embedding formalism for 3D spinors and compute the conformal blocks appearing in fermion 4-point functions. Using these results, we find general bounds on the dimensions of operators appearing in the ψ × ψ OPE, and also on the central charge CT. We observe features in our bounds that coincide with scaling dimensions in the GrossNeveu models at large N. Finally, we also speculate that other features could coincide with a fermionic CFT containing no relevant scalar operators.

  19. Bootstrapping 3D fermions

    SciTech Connect

    Iliesiu, Luca; Kos, Filip; Poland, David; Pufu, Silviu S.; Simmons-Duffin, David; Yacoby, Ran

    2016-03-17

    We study the conformal bootstrap for a 4-point function of fermions <ψψψψ> in 3D. We first introduce an embedding formalism for 3D spinors and compute the conformal blocks appearing in fermion 4-point functions. Using these results, we find general bounds on the dimensions of operators appearing in the ψ × ψ OPE, and also on the central charge CT. We observe features in our bounds that coincide with scaling dimensions in the GrossNeveu models at large N. Finally, we also speculate that other features could coincide with a fermionic CFT containing no relevant scalar operators.

  20. Scaffolds fabricated by 3D two-photon photopolymerization for live cell studies

    NASA Astrophysics Data System (ADS)

    Teplicky, T.; Cunderlikova, B.; Mateasik, A.; Vincze, A.; Chorvat, D.; Marcek Chorvatova, A.

    2016-12-01

    Design and fabrication of appropriate biocompatible microstructures that ensure fixation and control of experimental conditions for live cell and bacteria observations is an important prerequisite for number of real time experiments. Our approach is to design engineered microfabricated 3D structures for growth of cells in culture without significant modification of their metabolic state. Presented approach is aimed at evaluation of the potential applicability of biocompatible constructs in the biomedical field and thus live cell monitoring in controlled conditions. Design and evaluation of properties of materials and structures with mesoscopic arrangement and their interaction with biological objects is a prerequisite for establishment of physiologically relevant in vitro models of pathologies as well as for development of a new generation of nano / micro / bio-sensors.

  1. Experimental studies of cobalt ferrite nanoparticles doped silica matrix 3D magneto-photonic crystals

    NASA Astrophysics Data System (ADS)

    Abou Diwan, E.; Royer, F.; Kekesi, R.; Jamon, D.; Blanc-Mignon, M. F.; Neveu, S.; Rousseau, J. J.

    2013-05-01

    In this paper, we present the synthesis and the optical properties of 3D magneto-photonic structures. The elaboration process consists in firstly preparing then infiltrating polystyrene direct opals with a homogeneous solution of sol-gel silica precursors doped by cobalt ferrite nanoparticles, and finally dissolving the polystyrene spheres. Scanning Electron Microscopy (SEM) images of the prepared samples clearly evidence a periodic arrangement. Using a home-made polarimetric optical bench, the transmittance as a function of the wavelength, the Faraday rotation as a function of the applied magnetic field, and the Faraday ellipticity as a function of the wavelength and as a function of the applied magnetic field were measured. The existence of deep photonic band gaps (PBG), the unambiguous magnetic character of the samples and the qualitative modification of the Faraday ellipticity in the area of the PBG are evidenced.

  2. Enhanced ICP for the Registration of Large-Scale 3D Environment Models: An Experimental Study

    PubMed Central

    Han, Jianda; Yin, Peng; He, Yuqing; Gu, Feng

    2016-01-01

    One of the main applications of mobile robots is the large-scale perception of the outdoor environment. One of the main challenges of this application is fusing environmental data obtained by multiple robots, especially heterogeneous robots. This paper proposes an enhanced iterative closest point (ICP) method for the fast and accurate registration of 3D environmental models. First, a hierarchical searching scheme is combined with the octree-based ICP algorithm. Second, an early-warning mechanism is used to perceive the local minimum problem. Third, a heuristic escape scheme based on sampled potential transformation vectors is used to avoid local minima and achieve optimal registration. Experiments involving one unmanned aerial vehicle and one unmanned surface vehicle were conducted to verify the proposed technique. The experimental results were compared with those of normal ICP registration algorithms to demonstrate the superior performance of the proposed method. PMID:26891298

  3. The numerical study of the cavitation-structure interaction around 3D flexible hydrofoil

    NASA Astrophysics Data System (ADS)

    Shi-liang, Hu; Ying, Chen; Chuan-jing, Lu

    2015-12-01

    The closely coupled approach combined the Finite Volume Method (FVM) solver and the Finite Element Method (FEM) solver is applied to simulation the cavitation-structure interaction of a 3D cantilevered flexible hydrofoil in water tunnel. In the cavitating flow, the elastic hydrofoil would deform or vibrate in bending and twisting mode. And the motion of the foil would affect the characteristics of the cavity and the hydrodynamic load on the foil in turn. With smaller cavitation numbers (σv=2.15), the frequency spectrum of the lift on the foil would contain two frequencies which are associated to the cavity shedding and the first bend frequency of the hydrofoil. With larger cavitation number (σv=2.55), the frequency of the lift is completely dominated by the natural frequency of the foil.

  4. Quasi 3D ECE imaging system for study of MHD instabilities in KSTAR

    SciTech Connect

    Yun, G. S. Choi, M. J.; Lee, J.; Kim, M.; Leem, J.; Nam, Y.; Choe, G. H.; Lee, W.; Park, H. K.; Park, H.; Woo, D. S.; Kim, K. W.; Domier, C. W.; Luhmann, N. C.; Ito, N.; Mase, A.; Lee, S. G.

    2014-11-15

    A second electron cyclotron emission imaging (ECEI) system has been installed on the KSTAR tokamak, toroidally separated by 1/16th of the torus from the first ECEI system. For the first time, the dynamical evolutions of MHD instabilities from the plasma core to the edge have been visualized in quasi-3D for a wide range of the KSTAR operation (B{sub 0} = 1.7∼3.5 T). This flexible diagnostic capability has been realized by substantial improvements in large-aperture quasi-optical microwave components including the development of broad-band polarization rotators for imaging of the fundamental ordinary ECE as well as the usual 2nd harmonic extraordinary ECE.

  5. Enhanced ICP for the Registration of Large-Scale 3D Environment Models: An Experimental Study.

    PubMed

    Han, Jianda; Yin, Peng; He, Yuqing; Gu, Feng

    2016-02-15

    One of the main applications of mobile robots is the large-scale perception of the outdoor environment. One of the main challenges of this application is fusing environmental data obtained by multiple robots, especially heterogeneous robots. This paper proposes an enhanced iterative closest point (ICP) method for the fast and accurate registration of 3D environmental models. First, a hierarchical searching scheme is combined with the octree-based ICP algorithm. Second, an early-warning mechanism is used to perceive the local minimum problem. Third, a heuristic escape scheme based on sampled potential transformation vectors is used to avoid local minima and achieve optimal registration. Experiments involving one unmanned aerial vehicle and one unmanned surface vehicle were conducted to verify the proposed technique. The experimental results were compared with those of normal ICP registration algorithms to demonstrate the superior performance of the proposed method.

  6. Quasi 3D ECE imaging system for study of MHD instabilities in KSTAR.

    PubMed

    Yun, G S; Lee, W; Choi, M J; Lee, J; Kim, M; Leem, J; Nam, Y; Choe, G H; Park, H K; Park, H; Woo, D S; Kim, K W; Domier, C W; Luhmann, N C; Ito, N; Mase, A; Lee, S G

    2014-11-01

    A second electron cyclotron emission imaging (ECEI) system has been installed on the KSTAR tokamak, toroidally separated by 1/16th of the torus from the first ECEI system. For the first time, the dynamical evolutions of MHD instabilities from the plasma core to the edge have been visualized in quasi-3D for a wide range of the KSTAR operation (B0 = 1.7∼3.5 T). This flexible diagnostic capability has been realized by substantial improvements in large-aperture quasi-optical microwave components including the development of broad-band polarization rotators for imaging of the fundamental ordinary ECE as well as the usual 2nd harmonic extraordinary ECE.

  7. Thermocapillary Flow and Coalescences of Heterogeneous Bubble Size Diameter in a Rotating Cylinder: 3D Study

    NASA Astrophysics Data System (ADS)

    Alhendal, Yousuf; Turan, Ali

    2016-12-01

    Two dimensional axisymmetric and three-dimensional VOF simulations of gas/liquid transient flow were performed using a multiphase flow algorithm based on the finite-volume method. The results for motion of a multiple bubbles of a heterogeneous sizes aligned horizontally and perpendicular to a hot surface incorporating thermocapillary forces in a rotating liquid in a zero-gravity environment have been presented for the first time. No bubbles broke in any of the cases observed. The results also show that collision and agglomeration of bubbles of unequal sizes diameter are different from those of similar size diameters presented from earlier research work of Alhendal et al. Acta Astronaut. 117, 484-496 (2015). Different flow patterns such as thermocapillary bubble migration, collision, and stream function were observed and presented for the 2-D and 3-D models.

  8. Performance improvement study of a relativistic magnetron using MAGIC-3D

    SciTech Connect

    Maurya, S.; Singh, V.V.P.; Jain, P.K.

    2011-07-01

    A three dimensional particle-in-cell (PlC) code, MAGIC3D, is used to examine the performance improvement in a relativistic magnetron by perturbing technique. Asymmetrical metal rods of different length have been used to perturb the magnetic field in the annular sector of the resonant system. Enhancement up to 45% in the radiated output power has been obtained in the perturbed magnetic field case over the unperturbed one. It has also been found in the simulation that oscillation start up time is reduced by 16 %, and the amplitude of the nearest competing mode goes down 9dB compared to unperturbed case. Perturbed magnetic field also reduces the end caps current improving the efficiency. (author)

  9. Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation

    PubMed Central

    Jeon, Jessie S.; Bersini, Simone; Gilardi, Mara; Dubini, Gabriele; Charest, Joseph L.; Moretti, Matteo; Kamm, Roger D.

    2015-01-01

    A key aspect of cancer metastases is the tendency for specific cancer cells to home to defined subsets of secondary organs. Despite these known tendencies, the underlying mechanisms remain poorly understood. Here we develop a microfluidic 3D in vitro model to analyze organ-specific human breast cancer cell extravasation into bone- and muscle-mimicking microenvironments through a microvascular network concentrically wrapped with mural cells. Extravasation rates and microvasculature permeabilities were significantly different in the bone-mimicking microenvironment compared with unconditioned or myoblast containing matrices. Blocking breast cancer cell A3 adenosine receptors resulted in higher extravasation rates of cancer cells into the myoblast-containing matrices compared with untreated cells, suggesting a role for adenosine in reducing extravasation. These results demonstrate the efficacy of our model as a drug screening platform and a promising tool to investigate specific molecular pathways involved in cancer biology, with potential applications to personalized medicine. PMID:25524628

  10. Study of the internal magnetic field of Mercury through 3D hybrid simulations

    NASA Astrophysics Data System (ADS)

    Leclercq, Ludivine; Marcel Chanteur, Gerard; Modolo, Ronan; Leblanc, Francois; Schmidt, Carl; Langlais, Benoît; Thebault, Erwan

    2016-10-01

    In 1974, Mariner 10 discovered the intrinsic magnetic field of Mercury which interacts with the solar wind, leading to the formation of a magnetosphere. In spite of the recent MESSENGER observations, this magnetosphere remains quite unknown, especially in the Southern hemisphere. In order to improve our understanding of the Hermean magnetosphere, and to prepare the Bepi-Colombo mission (ESA/JAXA), we simulated the magnetized environment of Mercury using the model named LatHyS (LATMOS Hybrid Simulation). LatHyS is a 3D parallel multi-species hybrid code which has been applied to Mars, Titan and Ganymede, which has recently be improved by the implementation of a multi-grid method allowing to refine the spatial resolution near the planetary object (40 km in the case of Mercury). In order to investigate the Hermean environment, several hybrid simulations have been performed considering different internal field models, and results are compared with MESSENGER observations.

  11. Hydrocarbon Seeps Formations: a Study Using 3-D Seismic Attributes in Combination with Satellite Data

    NASA Astrophysics Data System (ADS)

    Garcia-Pineda, O. G.; MacDonald, I. R.; Shedd, W.

    2011-12-01

    Analyzing the magnitude of oil discharges from natural hydrocarbon seeps is important in improving our understanding of carbon contribution as oil migrates from deeper sediments to the water column, and then eventually to the atmosphere. Liquid hydrocarbon seepage in the deep water of the Gulf of Mexico (GOM) is associated with deep cutting faults, associated with vertical salt movement, that provide conduits for the upward migration of oil and gas. Seeps transform surface geology and generate prominent geophysical targets that can be identified on 3-D seismic data as seafloor amplitude anomalies maps that correlate with the underlying deep fault systems. Using 3D seismic data, detailed mapping of the northern GOM has identified more than 21,000 geophysical anomalies across the basin. In addition to seismic data, Synthetic Aperture Radar (SAR) images have proven to be a reliable tool for localizing natural seepage of oil. We used a Texture Classifier Neural Network Algorithm (TCNNA) to process more than 1200 SAR images collected over the GOM. We quantified more than 900 individual seep formations distributed along the continental shelf and in deep water. Comparison of the geophysical anomalies with the SAR oil slick targets shows good general agreement between the distributions of the two indicators. However, there are far fewer active oil slicks than geophysical anomalies, most of which are probably associated with gas seepage. By examining several sites where the location of active venting can be determined by submersibles observations, we found that the active oily vents are often spatially offset from the most intense geophysical targets (i.e. GC600, GC767, GC204, etc). In addition to the displacement of the oil by deep sea currents, we propose that during the 100K years of activity, the location of the vents on the seafloor probably migrate as carbonate cementation reduces the permeability of the upper sediment. Many of the geophysical targets may represent

  12. Efficacy of 3-D-imaging in minimally-invasive screw fixation of proximal phalanx fractures: A cadaveric study.

    PubMed

    Oldewurtel, Andreas; Kendoff, D; O'Loughlin, P F; Wolfhard, U; Olivier, L C

    2010-01-01

    The current study evaluated whether 3-D fluoroscopic imaging is capable of adequate visualisation, reduction and effective guidance of implant placement during a minimally-invasive screw-fixation (MISF) procedure in the treatment of proximal phalanx fractures. A comparison with conventional intraoperative 2-D imaging was performed in a cadaveric model. Conventional 2-D and 3-D imaging series were performed following the creation of proximal phalanx fractures, reduction and fixation, pre- and post-operatively. For both imaging modalities, attention was paid to A) correct reduction, B) screw-placement and, if present, C) intra-articular offset of fracture edges.The results revealed no related overall advantage of the 3-D imaging system over normal 2-D fluoroscopy at the proximal phalanx region. The authors conclude that, given the cost of 3-D imaging technology, as well as the increased time required for image acquisition, its routine use in the treatment of phalanx fracture cases is not justifiable at present.

  13. Human Liver Infection in a Dish: Easy-To-Build 3D Liver Models for Studying Microbial Infection

    PubMed Central

    Petropolis, Debora B.; Faust, Daniela M.; Tolle, Matthieu; Rivière, Lise; Valentin, Tanguy; Neuveut, Christine; Hernandez-Cuevas, Nora; Dufour, Alexandre; Olivo-Marin, Jean-Christophe; Guillen, Nancy

    2016-01-01

    Human liver infection is a major cause of death worldwide, but fundamental studies on infectious diseases affecting humans have been hampered by the lack of robust experimental models that accurately reproduce pathogen-host interactions in an environment relevant for the human disease. In the case of liver infection, one consequence of this absence of relevant models is a lack of understanding of how pathogens cross the sinusoidal endothelial barrier and parenchyma. To fill that gap we elaborated human 3D liver in vitro models, composed of human liver sinusoidal endothelial cells (LSEC) and Huh-7 hepatoma cells as hepatocyte model, layered in a structure mimicking the hepatic sinusoid, which enable studies of key features of early steps of hepatic infection. Built with established cell lines and scaffold, these models provide a reproducible and easy-to-build cell culture approach of reduced complexity compared to animal models, while preserving higher physiological relevance compared to standard 2D systems. For proof-of-principle we challenged the models with two hepatotropic pathogens: the parasitic amoeba Entamoeba histolytica and hepatitis B virus (HBV). We constructed four distinct setups dedicated to investigating specific aspects of hepatic invasion: 1) pathogen 3D migration towards hepatocytes, 2) hepatocyte barrier crossing, 3) LSEC and subsequent hepatocyte crossing, and 4) quantification of human hepatic virus replication (HBV). Our methods comprise automated quantification of E. histolytica migration and hepatic cells layer crossing in the 3D liver models. Moreover, replication of HBV virus occurs in our virus infection 3D liver model, indicating that routine in vitro assays using HBV or others viruses can be performed in this easy-to-build but more physiological hepatic environment. These results illustrate that our new 3D liver infection models are simple but effective, enabling new investigations on infectious disease mechanisms. The better

  14. 3D-printed soft-tissue physical models of renal malignancies for individualized surgical simulation: a feasibility study.

    PubMed

    Maddox, Michael M; Feibus, Allison; Liu, James; Wang, Julie; Thomas, Raju; Silberstein, Jonathan L

    2017-01-20

    To construct patient-specific physical three-dimensional (3D) models of renal units with materials that approximates the properties of renal tissue to allow pre-operative and robotic training surgical simulation, 3D physical kidney models were created (3DSystems, Rock Hill, SC) using computerized tomography to segment structures of interest (parenchyma, vasculature, collection system, and tumor). Images were converted to a 3D surface mesh file for fabrication using a multi-jet 3D printer. A novel construction technique was employed to approximate normal renal tissue texture, printers selectively deposited photopolymer material forming the outer shell of the kidney, and subsequently, an agarose gel solution was injected into the inner cavity recreating the spongier renal parenchyma. We constructed seven models of renal units with suspected malignancies. Partial nephrectomy and renorrhaphy were performed on each of the replicas. Subsequently all patients successfully underwent robotic partial nephrectomy. Average tumor diameter was 4.4 cm, warm ischemia time was 25 min, RENAL nephrometry score was 7.4, and surgical margins were negative. A comparison was made between the seven cases and the Tulane Urology prospectively maintained robotic partial nephrectomy database. Patients with surgical models had larger tumors, higher nephrometry score, longer warm ischemic time, fewer positive surgical margins, shorter hospitalization, and fewer post-operative complications; however, the only significant finding was lower estimated blood loss (186 cc vs 236; p = 0.01). In this feasibility study, pre-operative resectable physical 3D models can be constructed and used as patient-specific surgical simulation tools; further study will need to demonstrate if this results in improvement of surgical outcomes and robotic simulation education.

  15. Human Liver Infection in a Dish: Easy-To-Build 3D Liver Models for Studying Microbial Infection.

    PubMed

    Petropolis, Debora B; Faust, Daniela M; Tolle, Matthieu; Rivière, Lise; Valentin, Tanguy; Neuveut, Christine; Hernandez-Cuevas, Nora; Dufour, Alexandre; Olivo-Marin, Jean-Christophe; Guillen, Nancy

    2016-01-01

    Human liver infection is a major cause of death worldwide, but fundamental studies on infectious diseases affecting humans have been hampered by the lack of robust experimental models that accurately reproduce pathogen-host interactions in an environment relevant for the human disease. In the case of liver infection, one consequence of this absence of relevant models is a lack of understanding of how pathogens cross the sinusoidal endothelial barrier and parenchyma. To fill that gap we elaborated human 3D liver in vitro models, composed of human liver sinusoidal endothelial cells (LSEC) and Huh-7 hepatoma cells as hepatocyte model, layered in a structure mimicking the hepatic sinusoid, which enable studies of key features of early steps of hepatic infection. Built with established cell lines and scaffold, these models provide a reproducible and easy-to-build cell culture approach of reduced complexity compared to animal models, while preserving higher physiological relevance compared to standard 2D systems. For proof-of-principle we challenged the models with two hepatotropic pathogens: the parasitic amoeba Entamoeba histolytica and hepatitis B virus (HBV). We constructed four distinct setups dedicated to investigating specific aspects of hepatic invasion: 1) pathogen 3D migration towards hepatocytes, 2) hepatocyte barrier crossing, 3) LSEC and subsequent hepatocyte crossing, and 4) quantification of human hepatic virus replication (HBV). Our methods comprise automated quantification of E. histolytica migration and hepatic cells layer crossing in the 3D liver models. Moreover, replication of HBV virus occurs in our virus infection 3D liver model, indicating that routine in vitro assays using HBV or others viruses can be performed in this easy-to-build but more physiological hepatic environment. These results illustrate that our new 3D liver infection models are simple but effective, enabling new investigations on infectious disease mechanisms. The better

  16. Experimental study of 3-D, impulsive reconnection events in a laboratory plasma

    NASA Astrophysics Data System (ADS)

    Dorfman, Seth Elliot

    Fast, impulsive reconnection is commonly observed in laboratory, space and astrophysical plasmas. Many existing models of reconnection attempt to explain this behavior without including variation in the third direction. However, the impulsive reconnection events observed on the Magnetic Reconnection Experiment (MRX) which are described in this dissertation cannot be explained by 2-D models and are therefore fundamentally three-dimensional. These events include both a slow buildup phase and a fast current layer disruption phase. The buildup phase is characterized by a slow transition from collisional to collisionless reconnection and the formation of "flux rope" structures; these "flux ropes" are defined as 3-D high current density regions associated with an O point at the measurement location. In the disruption phase, the "flux ropes" are ejected from the reconnection layer as the total current drops and the reconnection rate spikes. Strong out-of-plane gradients in both the density and reconnecting magnetic field are another key feature of disruptive discharges; after finite upstream density is depleted by reconnection during the buildup phase, the out of plane magnetic field gradient flattens and this disruption spreads in the electron flow direction. Electromagnetic fluctuations in the lower hybrid frequency range are observed to peak at the disruption time; however, they are not the key physics responsible for the impulsive phenomena observed. Important features of the disruption dynamics cannot be explained by an anomalous resistivity model. Furthermore, an important discrepancy in the layer width and force balance between the collisionless regime of MRX and kinetic simulations persists when the fluctuations are small or absent, implying that they are not the cause of the wider electron layers observed in the experiment. These wider layers may instead be due to the formation of flux ropes with a wide range of sizes; consistent with this hypothesis, flux rope

  17. 3D Reconstruction of a Shallow Archaeological Site From High Resolution Acoustic Imagery: A Case Study

    NASA Astrophysics Data System (ADS)

    Plets, R. M.; Dix, J. K.; Adams, J. R.; Best, A. I.

    2005-12-01

    High resolution acoustic surveying for buried objects in the shallow waters of the inter-tidal to sub-tidal zone is a major challenge to many sectors of the marine surveying community. This is a consequence of a number of issues such as the relationship between water depth and acoustic acquisition geometry; problems of vessel induced bubble clouds reducing the signal-to-noise (SNR) ratio; and the necessity of high spatial survey accuracy in three-dimensions. These challenges are particularly acute for the marine archaeological community, who are frequently required to non-destructively investigate shallow-water (< 5 m) sites. This paper addresses these challenges and demonstrates the potential of imaging buried objects in extremely shallow environments by describing a seamless marine archaeological and geophysical investigation of a buried shipwreck: Henry V's `great flagship', the Grace Dieu (1418). The site, located in the Hamble River (UK), is typically covered by 2-5 m of water, and is partially buried within muddy inter-tidal sediments. At exceptionally low tides, during the spring equinox, a few of the marginal timbers are exposed. The marine survey utilised three different deployment methods of a Chirp system: two 2D Chirp systems, each emitting different frequencies and accompanied by different navigational systems (DGPS versus RTK), and a 3D Chirp system with RTK positioning capability. In all cases, the source was towed over the site using diver power. Close survey line spacing, accurate navigation and decimetre scale vertical and horizontal resolution acoustic data enabled the construction of a pseudo and full 3D image of this buried wreck site. This has been calibrated against known archaeological site investigation data and an RTK-GPS terrestrial survey. This data has identified the true plan form and dimensions of the remaining segments of the vessel, supporting the assertion that it was the most significant naval design for over two centuries. It has

  18. 3D reconstruction of scintillation light emission from proton pencil beams using limited viewing angles – a simulation study

    PubMed Central

    Hui, CheukKai; Robertson, Daniel; Beddar, Sam

    2015-01-01

    An accurate and high-resolution quality assurance (QA) method for proton radiotherapy beams is necessary to ensure correct dose delivery to the target. Detectors based on a large volume of liquid scintillator have shown great promise in providing fast and high-resolution measurements of proton treatment fields. However, previous work with these detectors has been limited to two-dimensional measurements, and the quantitative measurement of dose distributions was lacking. The purpose of the current study is to assess the feasibility of reconstructing three-dimensional (3D) scintillation light distributions of spot scanning proton beams using a scintillation system. The proposed system consists of a tank of liquid scintillator imaged by charge-coupled device cameras at three orthogonal viewing angles. Because of the limited number of viewing angles, we developed a profile-based technique to obtain an initial estimate that can improve the quality of the 3D reconstruction. We found that our proposed scintillator system and profile-based technique can reconstruct a single energy proton beam in 3D with a gamma passing rate (3%/3 mm local) of 100.0%. For asingle energy layer of an intensity modulated proton therapy prostate treatment plan, the proposed method can reconstruct the 3D light distribution with a gamma pass rate (3%/3 mm local) of 99.7%. In addition, we also found that the proposed method is effective in detecting errors in the treatment plan, indicating that it can be a very useful tool for 3D proton beam QA. PMID:25054735

  19. 3D reconstruction of scintillation light emission from proton pencil beams using limited viewing angles—a simulation study

    NASA Astrophysics Data System (ADS)

    Hui, CheukKai; Robertson, Daniel; Beddar, Sam

    2014-08-01

    An accurate and high-resolution quality assurance (QA) method for proton radiotherapy beams is necessary to ensure correct dose delivery to the target. Detectors based on a large volume of liquid scintillator have shown great promise in providing fast and high-resolution measurements of proton treatment fields. However, previous work with these detectors has been limited to two-dimensional measurements, and the quantitative measurement of dose distributions was lacking. The purpose of the current study is to assess the feasibility of reconstructing three-dimensional (3D) scintillation light distributions of spot scanning proton beams using a scintillation system. The proposed system consists of a tank of liquid scintillator imaged by charge-coupled device cameras at three orthogonal viewing angles. Because of the limited number of viewing angles, we developed a profile-based technique to obtain an initial estimate that can improve the quality of the 3D reconstruction. We found that our proposed scintillator system and profile-based technique can reconstruct a single energy proton beam in 3D with a gamma passing rate (3%/3 mm local) of 100.0%. For a single energy layer of an intensity modulated proton therapy prostate treatment plan, the proposed method can reconstruct the 3D light distribution with a gamma pass rate (3%/3 mm local) of 99.7%. In addition, we also found that the proposed method is effective in detecting errors in the treatment plan, indicating that it can be a very useful tool for 3D proton beam QA.

  20. Orthodontic intrusion of maxillary incisors: a 3D finite element method study

    PubMed Central

    Saga, Armando Yukio; Maruo, Hiroshi; Argenta, Marco André; Maruo, Ivan Toshio; Tanaka, Orlando Motohiro

    2016-01-01

    Objective: In orthodontic treatment, intrusion movement of maxillary incisors is often necessary. Therefore, the objective of this investigation is to evaluate the initial distribution patterns and magnitude of compressive stress in the periodontal ligament (PDL) in a simulation of orthodontic intrusion of maxillary incisors, considering the points of force application. Methods: Anatomic 3D models reconstructed from cone-beam computed tomography scans were used to simulate maxillary incisors intrusion loading. The points of force application selected were: centered between central incisors brackets (LOAD 1); bilaterally between the brackets of central and lateral incisors (LOAD 2); bilaterally distal to the brackets of lateral incisors (LOAD 3); bilaterally 7 mm distal to the center of brackets of lateral incisors (LOAD 4). Results and Conclusions: Stress concentrated at the PDL apex region, irrespective of the point of orthodontic force application. The four load models showed distinct contour plots and compressive stress values over the midsagittal reference line. The contour plots of central and lateral incisors were not similar in the same load model. LOAD 3 resulted in more balanced compressive stress distribution. PMID:27007765

  1. [Size dependent SERS activity of gold nanoparticles studied by 3D-FDTD simulation].

    PubMed

    Li, Li-mei; Fang, Ping-ping; Yang, Zhi-lin; Huang, Wen-da; Wu, De-yin; Ren, Bin; Tian, Zhong-qun

    2009-05-01

    By synthesizing Au nanoparticles with the controllable size from about 16 to 160 nm and measuring their SERS activity, the authors found that Au nanoparticles film with a size in the range of 120-135 nm showed the highest SERS activity with the 632.8 nm excitation, which is different from previous experimental results and theoretical predictions. The three dimensional finite difference time domain (3D-FDTD)method was employed to simulate the size dependent SERS activity. At the 632.8 nm excitation, the particles with a size of 110 nm shows the highest enhancement under coupling condition and presents an enhancement as high as 10(9) at the hot site. If the enhancement is averaged over the whole surface, the enhancement can still be as high as 10(7), in good agreement with our experimental data. For Au nanoparticles with a larger size such as 220 nm, the multipolar effect leads to the appearance of the second maximum enhancement with the increase in particles size. The averaged enhancement for the excitation line of 325 nm is only 10(2).

  2. Study of a dense, coronal thick target source with the microwave data and 3D modeling

    NASA Astrophysics Data System (ADS)

    Fleishman, Gregory; Xu, Yan

    2015-04-01

    We present a detailed 3D modeling of a dense, coronal thick target X-ray flare using the GX Simulator tool, photospheric magnetic measurements, and microwave data. The developed model offers a remarkable agreement between the synthesized and observed spectra and images in both X-ray and microwave domains, which validates the entire model. The flaring loop parameters validated via the modeling are fully consistent with those derived from the X-ray spectral fit, but do not easily agree with those derived from the fit of the X-ray image sizes computed at various energies. Specifically, the plasma density obtained in the modeling is noticeably smaller than that derived from the size fit. The performed modeling suggests that the accelerated electrons are trapped at the coronal part of the flaring loop by a turbulence, while proves that the data are clearly inconsistent with the electron magnetic trapping in the weak diffusion regime mediated by the Coulomb collisions. Thus, the modeling confirms the interpretation of the coronal thick-target sources as the sites of electron acceleration in flares.This work was supported in part by NSF grants AGS-1250374, AGS-1262772, AGS-1153424, AGS-1348513, and AGS-1408703 and NASA grants NNX14AC87G and NNX-13AG13G to New Jersey Institute of Technology.

  3. Simulation study of a novel 3D SPAD pixel in an advanced FD-SOI technology

    NASA Astrophysics Data System (ADS)

    Vignetti, M. M.; Calmon, F.; Lesieur, P.; Savoy-Navarro, A.

    2017-02-01

    In this paper, a novel SPAD architecture implemented in a Fully-Depleted Silicon-On-Insulator (SOI) CMOS technology is presented. Thanks to its intrinsic vertical 3D structure, the proposed solution is expected to allow further scaling of the pixel size while ensuring high fill factors. Moreover the pixel and the detector electronics can benefit of the well-known advantages brought by SOI technology with respect to bulk CMOS, such as higher speed and lower power consumption. TCAD simulations based on realistic process parameters and dedicated post-processing analysis are carried out in order to optimize and validate the avalanche diode architecture for an optimal electric field distribution in the device but also to extract the main parameters of the SPAD, such as the breakdown voltage, the avalanche triggering probability, the dark count rate and the photon detection probability. A comparison between the efficiency in back-side and front-side approaches is carried out with a particular focus on time-of-flight applications.

  4. Study of strength properties of ceramic composites with soft filler based on 3D computer simulation

    NASA Astrophysics Data System (ADS)

    Smolin, Alexey Yu.; Smolin, Igor Yu.; Smolina, Irina Yu.

    2016-11-01

    The movable cellular automaton method which is a computational method of particle mechanics is applied to simulating uniaxial compression of 3D specimens of a ceramic composite. Soft inclusions were considered explicitly by changing the sort (properties) of automata selected randomly from the original fcc packing. The distribution of inclusions in space, their size, and the total fraction were varied. For each value of inclusion fraction, there were generated several representative specimens with individual pore position in space. The resulting magnitudes of the elastic modulus and strength of the specimens were scattered and well described by the Weibull distribution. We showed that to reveal the dependence of the elastic and strength properties of the composite on the inclusion fraction it is much better to consider the mathematical expectation of the corresponding Weibull distribution, rather than the average of the values for the specimens of the same inclusion fraction. It is shown that the relation between the mechanical properties of material and its inclusion fraction depends significantly on the material structure. Namely, percolation transition from isolated inclusions to interconnected clusters of inclusions strongly manifests itself in the dependence of strength on the fraction of inclusions. Thus, the curve of strength versus inclusion fraction fits different equations for a different kind of structure.

  5. Generating 3D Images of Sub-glacial Landscapes: Three Antarctic Case Studies

    NASA Astrophysics Data System (ADS)

    King, E. C.

    2011-12-01

    The formation mechanism of subglacial landforms such as drumlins and mega-scale glacial lineations remains controversial. Factors include the type and properties of subglacial sediments; the availability and pressurization of water; and the thickness and flow speed of the overlying ice. While new survey techniques have allowed increasingly sophisticated quantification of the morphology of palaeo-bedforms, observation of contemporary examples has remained difficult, thus inhibiting the development of viable models of formation. I have undertaken ground-radar surveys of three currently-active Antarctic ice streams (Rutford Ice Stream, Talutis Inlet and Pine Island Glacier) to map the type and distribution of subglacial landforms to provide primary observations to inform this debate. Each survey used a low frequency (2-4 MHz) impulse radar towed behind a snowmobile. Line spacing was 500 m and along-track trace interval was c. 7.5 m. The processing techniques used to turn raw profile data into 3D landscape images will be described. The technique works well for elongate sub-glacial bedforms but has limitations in accurately mapping bedform terminations and complex bedrock outcrop landscapes. Developments underway for the future include using a robot snowmobile for data acquisition and airborne survey with similar geometry.

  6. Utilization of 3D printing for an intravital microscopy platform to study the intestinal microcirculation.

    PubMed

    Burkovskiy, I; Lehmann, C; Jiang, C; Zhou, J

    2016-11-01

    Intravital microscopy of the intestine is a sophisticated technique that allows qualitative and quantitative in vivo observation of dynamic cellular interactions and blood flow at a high resolution. Physiological conditions of the animal and in particular of the observed organ, such as temperature and moisture are crucial for intravital imaging. Often, the microscopy stage with the animal or the organ of interest imposes limitations on how well the animal can be maintained. In addition, the access for additional oxygen supply or drug administration during the procedure is rather restricted. To address these limitations, we developed a novel intravital microscopy platform, allowing us to have improved access to the animal during the intravital microscopy procedure, as well as improved microenvironmental maintenance. The production process of this prototype platform is based on 3D printing of device parts in a single-step process. The simplicity of production and the advantages of this versatile and customizable design are shown and discussed in this paper. Our design potentially represents a major step forward in facilitating intestinal intravital imaging using fluorescent microscopy.

  7. Study on 3-D simulation of flow and turbidity in an oxbow lake in tidal compartment

    NASA Astrophysics Data System (ADS)

    Yokoyama, H.; Momonoe, H.; Hamamoto, S.

    2010-12-01

    We aimed to make flow and turbidity simulation model for an oxbow lake in tidal compartment. The oxbow has two bottle-necks and inflow river from urban district. Bed topography of the oxbow is former meandering channel of large-basin river. Therefore characteristic of flow and water quality is complex. First, field observation was conducted to clarify the characteristics of flow and water quality in the oxbow. From observation results, flow and resuspension phenomena in the oxbow were affected by wind and tide, and the balance of the two factors changed longitudinally. Next, we built 3-D simulation model of flow which took account of the field observation results. In order to investigate effective water quality improvement, we set some test cases: condition of wind, inflow river were changed. From the simulation results, tide was the most important factor, however at the upper part of the oxbow, where the tidal power seemed to be weaker, flow and turbidity were clearly affected by the wind.

  8. Evaluation of 3D modality-independent elastography for breast imaging: a simulation study

    NASA Astrophysics Data System (ADS)

    Ou, J. J.; Ong, R. E.; Yankeelov, T. E.; Miga, M. I.

    2008-01-01

    This paper reports on the development and preliminary testing of a three-dimensional implementation of an inverse problem technique for extracting soft-tissue elasticity information via non-rigid model-based image registration. The modality-independent elastography (MIE) algorithm adjusts the elastic properties of a biomechanical model to achieve maximal similarity between images acquired under different states of static loading. A series of simulation experiments with clinical image sets of human breasts were performed to test the ability of the method to identify and characterize a radiographically occult stiff lesion. Because boundary conditions are a critical input to the algorithm, a comparison of three methods for semi-automated surface point correspondence was conducted in the context of systematic and randomized noise processes. The results illustrate that 3D MIE was able to successfully reconstruct elasticity images using data obtained from both magnetic resonance and x-ray computed tomography systems. The lesion was localized correctly in all cases and its relative elasticity found to be reasonably close to the true values (3.5% with the use of spatial priors and 11.6% without). In addition, the inaccuracies of surface registration performed with thin-plate spline interpolation did not exceed empiric thresholds of unacceptable boundary condition error.

  9. Age Dependence of Wind Properties for Solar-type Stars: A 3D Study

    NASA Astrophysics Data System (ADS)

    Réville, Victor; Folsom, Colin P.; Strugarek, Antoine; Brun, Allan Sacha

    2016-12-01

    Young and rapidly rotating stars are known for intense, dynamo-generated magnetic fields. Spectropolarimetric observations of those stars in precisely aged clusters are key input for gyrochronology and magnetochronology. We use Zeeman Doppler imaging maps of several young K-type stars of similar mass and radius but with various ages and rotational periods to perform three-dimensional (3D) numerical MHD simulations of their coronae and follow the evolution of their magnetic properties with age. Those simulations yield the coronal structure as well as the instant torque exerted by the magnetized, rotating wind on the star. As stars get older, we find that the angular momentum loss decreases with {{{Ω }}}\\star 3, which is the reason for the convergence on the Skumanich law. For the youngest stars of our sample, the angular momentum loss shows signs of saturation around 8{{{Ω }}}⊙ , which is a common value used in spin evolution models for K-type stars. We compare these results to semianalytical models and existing braking laws. We observe a complex wind-speed distribution for the youngest stars with slow, intermediate, and fast wind components, which are the result of interaction with intense and nonaxisymmetric magnetic fields. Consequently, in our simulations, the stellar wind structure in the equatorial plane of young stars varies significantly from a solar configuration, delivering insight about the past of the solar system interplanetary medium.

  10. Mechanistic and quantitative studies of bystander response in 3D tissues for low-dose radiation risk estimations

    SciTech Connect

    Amundson, Sally A.

    2013-06-12

    We have used the MatTek 3-dimensional human skin model to study the gene expression response of a 3D model to low and high dose low LET radiation, and to study the radiation bystander effect as a function of distance from the site of irradiation with either alpha particles or low LET protons. We have found response pathways that appear to be specific for low dose exposures, that could not have been predicted from high dose studies. We also report the time and distance dependent expression of a large number of genes in bystander tissue. the bystander response in 3D tissues showed many similarities to that described previously in 2D cultured cells, but also showed some differences.

  11. Use of High Resolution 3D Diffusion Tensor Imaging to Study Brain White Matter Development in Live Neonatal Rats

    PubMed Central

    Cai, Yu; McMurray, Matthew S.; Oguz, Ipek; Yuan, Hong; Styner, Martin A.; Lin, Weili; Johns, Josephine M.; An, Hongyu

    2011-01-01

    High resolution diffusion tensor imaging (DTI) can provide important information on brain development, yet it is challenging in live neonatal rats due to the small size of neonatal brain and motion-sensitive nature of DTI. Imaging in live neonatal rats has clear advantages over fixed brain scans, as longitudinal and functional studies would be feasible to understand neuro-developmental abnormalities. In this study, we developed imaging strategies that can be used to obtain high resolution 3D DTI images in live neonatal rats at postnatal day 5 (PND5) and PND14, using only 3 h of imaging acquisition time. An optimized 3D DTI pulse sequence and appropriate animal setup to minimize physiological motion artifacts are the keys to successful high resolution 3D DTI imaging. Thus, a 3D rapid acquisition relaxation enhancement DTI sequence with twin navigator echoes was implemented to accelerate imaging acquisition time and minimize motion artifacts. It has been suggested that neonatal mammals possess a unique ability to tolerate mild-to-moderate hypothermia and hypoxia without long term impact. Thus, we additionally utilized this ability to minimize motion artifacts in magnetic resonance images by carefully suppressing the respiratory rate to around 15/min for PND5 and 30/min for PND14 using mild-to-moderate hypothermia. These imaging strategies have been successfully implemented to study how the effect of cocaine exposure in dams might affect brain development in their rat pups. Image quality resulting from this in vivo DTI study was comparable to ex vivo scans. fractional anisotropy values were also similar between the live and fixed brain scans. The capability of acquiring high quality in vivo DTI imaging offers a valuable opportunity to study many neurological disorders in brain development in an authentic living environment. PMID:22013426

  12. A multifunctional 3D co-culture system for studies of mammary tissue morphogenesis and stem cell biology.

    PubMed

    Campbell, Jonathan J; Davidenko, Natalia; Caffarel, Maria M; Cameron, Ruth E; Watson, Christine J

    2011-01-01

    Studies on the stem cell niche and the efficacy of cancer therapeutics require complex multicellular structures and interactions between different cell types and extracellular matrix (ECM) in three dimensional (3D) space. We have engineered a 3D in vitro model of mammary gland that encompasses a defined, porous collagen/hyaluronic acid (HA) scaffold forming a physiologically relevant foundation for epithelial and adipocyte co-culture. Polarized ductal and acinar structures form within this scaffold recapitulating normal tissue morphology in the absence of reconstituted basement membrane (rBM) hydrogel. Furthermore, organoid developmental outcome can be controlled by the ratio of collagen to HA, with a higher HA concentration favouring acinar morphological development. Importantly, this culture system recapitulates the stem cell niche as primary mammary stem cells form complex organoids, emphasising the utility of this approach for developmental and tumorigenic studies using genetically altered animals or human biopsy material, and for screening cancer therapeutics for personalised medicine.

  13. A primary study of appropriate intraoral scanning frequency of single 3D image

    NASA Astrophysics Data System (ADS)

    Li, Hong; Lyu, Peijun; Sun, Yuchun; Wang, Yong; Liang, Xiaoyue

    2015-07-01

    Objective To make a quantitative analysis between sampling frequencies and micro-movement distance of mark points on tooth surfaces, and to provide a reference for sampling frequency settings of intraoral scanning systems. Methods Mark points affixed to the incisors of five subjects. In total, 3600 groups of tracking point coordinates were obtained with frequencies of 60, 150 and 300 Hz using an optical 3D tracking system. The data was then re-sampled to obtain coordinates at lower frequencies (5, 10, 15 and 20 Hz) at equal intervals of groups of tracking point coordinates. Change in distance (Δd) was defined as the change in position of a single v from one sampling time point to another, and was valued by clinical accuracy requirement (20-100μm). The curve equation was fit quantitatively between Δd median (M) and the sampling frequency (f). The difference between upper and lower incisor mark points were analyzed by a non-parametric test; α=0.05. Result When the frequency (f) was 60 Hz, upper jaw Δd median (M) and interquartile (Q) were 14.4 μm and 9.2 μm, respectively, while the lower Δd(M) and (Q) were 6.4 μm and 10.2 μm, respectively. Every Δd value was less than 100 μm, while 74% of Δd vales were less than 20 μm. Δd(M) and f satisfy the power curve equation: Δd(M)=0.526×f-0.979(f∈[5,300]). Significant differences of incisor feature points were noted between upper and lower jaws of the same subject (P<0.01). Conclusion Clinical accuracy can be met when the sampling frequency of the intraoral scanning system is 60 Hz.

  14. Study of a non-diffusing radiochromic gel dosimeter for 3D radiation dose imaging

    NASA Astrophysics Data System (ADS)

    Marsden, Craig Michael

    2000-12-01

    This thesis investigates the potential of a new radiation gel dosimeter, based on nitro-blue tetrazolium (NBTZ) suspended in a gelatin mold. Unlike all Fricke based gel dosimeters this dosimeter does not suffer from diffusive loss of image stability. Images are obtained by an optical tomography method. Nitro blue tetrazolium is a common biological indicator that when irradiated in an aqueous medium undergoes reduction to a highly colored formazan, which has an absorbance maximum at 525nm. Tetrazolium is water soluble while the formazan product is insoluble. The formazan product sticks to the gelatin matrix and the dose image is maintained for three months. Methods to maximize the sensitivity of the system were evaluated. It was found that a chemical detergent, Triton X-100, in combination with sodium formate, increased the dosimeter sensitivity significantly. An initial G-value of formazan production for a dosimeter composed of 1mM NBTZ, gelatin, and water was on the order of 0.2. The addition of Triton and formate produced a G-value in excess of 5.0. The effects of NBTZ, triton, formate, and gel concentration were all investigated. All the gels provided linear dose vs. absorbance plots for doses from 0 to >100 Gy. It was determined that gel concentration had minimal if any effect on sensitivity. Sensitivity increased slightly with increasing NBTZ concentration. Triton and formate individually and together provided moderate to large increases in dosimeter sensitivity. The dosimeter described in this work can provide stable 3D radiation dose images for all modalities of radiation therapy equipment. Methods to increase sensitivity are developed and discussed.

  15. Integrative multicellular biological modeling: a case study of 3D epidermal development using GPU algorithms

    PubMed Central

    2010-01-01

    Background Simulation of sophisticated biological models requires considerable computational power. These models typically integrate together numerous biological phenomena such as spatially-explicit heterogeneous cells, cell-cell interactions, cell-environment interactions and intracellular gene networks. The recent advent of programming for graphical processing units (GPU) opens up the possibility of developing more integrative, detailed and predictive biological models while at the same time decreasing the computational cost to simulate those models. Results We construct a 3D model of epidermal development and provide a set of GPU algorithms that executes significantly faster than sequential central processing unit (CPU) code. We provide a parallel implementation of the subcellular element method for individual cells residing in a lattice-free spatial environment. Each cell in our epidermal model includes an internal gene network, which integrates cellular interaction of Notch signaling together with environmental interaction of basement membrane adhesion, to specify cellular state and behaviors such as growth and division. We take a pedagogical approach to describing how modeling methods are efficiently implemented on the GPU including memory layout of data structures and functional decomposition. We discuss various programmatic issues and provide a set of design guidelines for GPU programming that are instructive to avoid common pitfalls as well as to extract performance from the GPU architecture. Conclusions We demonstrate that GPU algorithms represent a significant technological advance for the simulation of complex biological models. We further demonstrate with our epidermal model that the integration of multiple complex modeling methods for heterogeneous multicellular biological processes is both feasible and computationally tractable using this new technology. We hope that the provided algorithms and source code will be a starting point for modelers to

  16. 3D Case Studies of Monitoring Dynamic Structural Tests using Long Exposure Imagery

    NASA Astrophysics Data System (ADS)

    McCarthy, D. M. J.; Chandler, J. H.; Palmeri, A.

    2014-06-01

    Structural health monitoring uses non-destructive testing programmes to detect long-term degradation phenomena in civil engineering structures. Structural testing may also be carried out to assess a structure's integrity following a potentially damaging event. Such investigations are increasingly carried out with vibration techniques, in which the structural response to artificial or natural excitations is recorded and analysed from a number of monitoring locations. Photogrammetry is of particular interest here since a very high number of monitoring locations can be measured using just a few images. To achieve the necessary imaging frequency to capture the vibration, it has been necessary to reduce the image resolution at the cost of spatial measurement accuracy. Even specialist sensors are limited by a compromise between sensor resolution and imaging frequency. To alleviate this compromise, a different approach has been developed and is described in this paper. Instead of using high-speed imaging to capture the instantaneous position at each epoch, long-exposure images are instead used, in which the localised image of the object becomes blurred. The approach has been extended to create 3D displacement vectors for each target point via multiple camera locations, which allows the simultaneous detection of transverse and torsional mode shapes. The proposed approach is frequency invariant allowing monitoring of higher modal frequencies irrespective of a sampling frequency. Since there is no requirement for imaging frequency, a higher image resolution is possible for the most accurate spatial measurement. The results of a small scale laboratory test using off-the-shelf consumer cameras are demonstrated. A larger experiment also demonstrates the scalability of the approach.

  17. Study of materials and machines for 3D printed large-scale, flexible electronic structures using fused deposition modeling

    NASA Astrophysics Data System (ADS)

    Hwang, Seyeon

    The 3 dimensional printing (3DP), called to additive manufacturing (AM) or rapid prototyping (RP), is emerged to revolutionize manufacturing and completely transform how products are designed and fabricated. A great deal of research activities have been carried out to apply this new technology to a variety of fields. In spite of many endeavors, much more research is still required to perfect the processes of the 3D printing techniques especially in the area of the large-scale additive manufacturing and flexible printed electronics. The principles of various 3D printing processes are briefly outlined in the Introduction Section. New types of thermoplastic polymer composites aiming to specified functional applications are also introduced in this section. Chapter 2 shows studies about the metal/polymer composite filaments for fused deposition modeling (FDM) process. Various metal particles, copper and iron particles, are added into thermoplastics polymer matrices as the reinforcement filler. The thermo-mechanical properties, such as thermal conductivity, hardness, tensile strength, and fracture mechanism, of composites are tested to figure out the effects of metal fillers on 3D printed composite structures for the large-scale printing process. In Chapter 3, carbon/polymer composite filaments are developed by a simple mechanical blending process with an aim of fabricating the flexible 3D printed electronics as a single structure. Various types of carbon particles consisting of multi-wall carbon nanotube (MWCNT), conductive carbon black (CCB), and graphite are used as the conductive fillers to provide the thermoplastic polyurethane (TPU) with improved electrical conductivity. The mechanical behavior and conduction mechanisms of the developed composite materials are observed in terms of the loading amount of carbon fillers in this section. Finally, the prototype flexible electronics are modeled and manufactured by the FDM process using Carbon/TPU composite filaments and

  18. SU-E-T-419: Fabricating Cerrobend Grids with 3D Printing for Spatially Modulated Radiation Therapy: A Feasibility Study

    SciTech Connect

    Zhu, X; Driewer, J; Lei, Y; Zheng, D; Li, S; Zhang, Q; Zhang, M; Zhou, S; Cullip, T; Chang, S

    2015-06-15

    Purpose: Grid therapy has promising applications in the radiation treatment of bulky and large tumors. However, research and applications of grid therapy is limited by the accessibility of the specialized blocks that produce the grid of pencil-like radiation beams. In this study, a Cerrobend grid block was fabricated using a 3D printing technique. Methods: A grid block mold was designed with divergent tubes following beam central rays. The mold was printed using a resin with the working temperature below 230 °C. The melted Cerrobend liquid at 120°oC was cast into the resin mold to yield a block with a thickness of 7.4 cm. The grid had a hexagonal pattern, with each pencil beam diameter of 1.4 cm at the iso-center plane; the distance between the beam centers was 2 cm. The dosimetric properties of the grid block were studied using radiographic film and small field dosimeters. Results: the grid block was fabricated to be mounted at the third accessory mount of a Siemens Oncor linear accelerator. Fabricating a grid block using 3D printing is similar to making cutouts for traditional radiotherapy photon blocks, with the difference being that the mold was created by a 3D printer rather than foam. In this study, the valley-to-peak ratio for a 6MV photon grid beam was 20% at dmax, and 30% at 10 cm depth, respectively. Conclusion: We have demonstrated a novel process for implementing grid radiotherapy using 3D printing techniques. Compared to existing approaches, our technique combines reduced cost, accessibility, and flexibility in customization with efficient delivery. This lays the groundwork for future studies to improve our understanding of the efficacy of grid therapy and apply it to improve cancer treatment.

  19. 3D photoacoustic imaging

    NASA Astrophysics Data System (ADS)

    Carson, Jeffrey J. L.; Roumeliotis, Michael; Chaudhary, Govind; Stodilka, Robert Z.; Anastasio, Mark A.

    2010-06-01

    Our group has concentrated on development of a 3D photoacoustic imaging system for biomedical imaging research. The technology employs a sparse parallel detection scheme and specialized reconstruction software to obtain 3D optical images using a single laser pulse. With the technology we have been able to capture 3D movies of translating point targets and rotating line targets. The current limitation of our 3D photoacoustic imaging approach is its inability ability to reconstruct complex objects in the field of view. This is primarily due to the relatively small number of projections used to reconstruct objects. However, in many photoacoustic imaging situations, only a few objects may be present in the field of view and these objects may have very high contrast compared to background. That is, the objects have sparse properties. Therefore, our work had two objectives: (i) to utilize mathematical tools to evaluate 3D photoacoustic imaging performance, and (ii) to test image reconstruction algorithms that prefer sparseness in the reconstructed images. Our approach was to utilize singular value decomposition techniques to study the imaging operator of the system and evaluate the complexity of objects that could potentially be reconstructed. We also compared the performance of two image reconstruction algorithms (algebraic reconstruction and l1-norm techniques) at reconstructing objects of increasing sparseness. We observed that for a 15-element detection scheme, the number of measureable singular vectors representative of the imaging operator was consistent with the demonstrated ability to reconstruct point and line targets in the field of view. We also observed that the l1-norm reconstruction technique, which is known to prefer sparseness in reconstructed images, was superior to the algebraic reconstruction technique. Based on these findings, we concluded (i) that singular value decomposition of the imaging operator provides valuable insight into the capabilities of

  20. Docking and 3-D QSAR studies on the binding of tetrahydropyrimid-2-one HIV-1 protease inhibitors

    NASA Astrophysics Data System (ADS)

    Rao, Shashidhar N.; Balaji, Govardhan A.; Balaji, Vitukudi N.

    2013-06-01

    We present molecular docking and 3-D QSAR studies on a series of tetrahydropyrimid-2-one HIV-1 protease inhibitors whose binding affinities to the enzyme span nearly 6 orders of magnitude. The docking investigations have been carried out with Surflex (GEOM, GEOMX) and Glide (SP and XP) methodologies available through Tripos and Schrodinger suite of tools in the context of Sybyl-X and Maestro interfaces, respectively. The alignments for 3-D QSAR studies were obtained by using the automated Surflex-SIM methodology in Sybyl-X and the analyses were performed using the CoMFA and CoMSIA methods. Additionally, the top-ranked poses obtained from various docking protocols were also employed to generate CoMFA and CoMSIA models to evaluate the qualitative consistency of the docked models with experimental data. Our studies demonstrate that while there are a number of common features in the docked models obtained from Surflex-dock and Glide methodologies, the former sets of models are generally better correlated with deduced experimental binding modes based on the X-ray structures of known HIV-1 protease complexes with cyclic ureas. The urea moiety common to all the ligands are much more tightly aligned in Surflex docked structures than in the models obtained from Glide SP and XP dockings. The 3-D QSAR models are qualitatively and quantitatively similar to those previously reported, suggesting the utility of automatically generated alignments from Surflex-SIM methodology.

  1. Pharmacophore modeling, 3D-QSAR and docking study of 2-phenylpyrimidine analogues as selective PDE4B inhibitors.

    PubMed

    Tripuraneni, Naga Srinivas; Azam, Mohammed Afzal

    2016-04-07

    Pharmacophore modeling, molecular docking, and molecular dynamics (MD) simulation studies have been performed, to explore the putative binding modes of 2-phenylpyrimidine series as PDE4B selective inhibitors. A five point pharmacophore model was developed using 87 molecules having pIC50 ranging from 8.52 to 5.07. The pharmacophore hypothesis yielded a statistically significant 3D-QSAR model, with a high correlation coefficient (R(2)=0.918), cross validation coefficient (Q(2)=0.852), and F value (175) at 4 component PLS factor. The external validation indicated that our QSAR model possessed high predictive power (R(2)=0.70). The generated model was further validated by enrichment studies using the decoy test. To evaluate the effectiveness of docking protocol in flexible docking, we have selected crystallographic bound compound to validate our docking procedure as evident from root mean square deviation. A 10ns molecular dynamics simulation confirmed the docking results of both stability of the 1XMU-ligand complex and the presumed active conformation. Further, similar orientation was observed between the superposition of the conformations of 85 after MD simulation and best XP-docking pose; MD simulation and 3D-QSAR pose; best XP-docking and 3D-QSAR poses. Outcomes of the present study provide insight in designing novel molecules with better PDE4B selective inhibitory activity.

  2. Microencapsulation of Neuroblastoma Cells and Mesenchymal Stromal Cells in Collagen Microspheres: A 3D Model for Cancer Cell Niche Study

    PubMed Central

    Yeung, Pan; Sin, Hoi Shun; Chan, Shing; Chan, Godfrey Chi Fung; Chan, Barbara Pui

    2015-01-01

    There is a growing trend for researchers to use in vitro 3D models in cancer studies, as they can better recapitulate the complex in vivo situation. And the fact that the progression and development of tumor are closely associated to its stromal microenvironment has been increasingly recognized. The establishment of such tumor supportive niche is vital in understanding tumor progress and metastasis. The mesenchymal origin of many cells residing in the cancer niche provides the rationale to include MSCs in mimicking the niche in neuroblastoma. Here we co-encapsulate and co-culture NBCs and MSCs in a 3D in vitro model and investigate the morphology, growth kinetics and matrix remodeling in the reconstituted stromal environment. Results showed that the incorporation of MSCs in the model lead to accelerated growth of cancer cells as well as recapitulation of at least partially the tumor microenvironment in vivo. The current study therefore demonstrates the feasibility for the collagen microsphere to act as a 3D in vitro cancer model for various topics in cancer studies. PMID:26657086

  3. Study of the structure of 3D-ordered macroporous GaN-ZnS:Mn nanocomposite films

    SciTech Connect

    Kurdyukov, D. A. Shishkin, I. I.; Grudinkin, S. A.; Sitnikova, A. A.; Zamoryanskaya, M. V.; Golubev, V. G.

    2015-05-15

    A film-type 3D-ordered macroporous GaN-ZnS:Mn nanocomposite with the structure of an inverted opal is fabricated. Structural studies of the nanocomposite are performed, and it is shown that GaN and ZnS:Mn introduced into the pores of the silica opal are nanocrystallites misoriented with respect to each other. It is shown that the nanocomposite is a structurally perfect 3D photonic crystal. The efficiency of using a buffer of GaN crystallites to preclude interaction between the surface of the spherical a-SiO{sub 2} particles forming the opal matrix and chemically active substances introduced into the pores is demonstrated.

  4. A comparative study of Rayleigh-Taylor and Richtmyer-Meshkov instabilities in 2D and 3D in tantalum

    NASA Astrophysics Data System (ADS)

    Sternberger, Z.; Maddox, B. R.; Opachich, Y. P.; Wehrenberg, C. E.; Kraus, R. G.; Remington, B. A.; Randall, G. C.; Farrell, M.; Ravichandran, G.

    2017-01-01

    Driving a shock wave through the interface between two materials with different densities can result in the Richtmyer-Meshkov or Rayleigh-Taylor instability and initial perturbations at the interface will grow. If the shock wave is sufficiently strong, the instability will lead to plastic flow at the interface. Material strength will reduce the amount of plastic flow and suppress growth. While such instabilities have been investigated in 2D, no studies of this phenomena have been performed in 3D on materials with strength. Initial perturbations to seed the hydrodynamic instability were coined into tantalum recovery targets. Two types of perturbations were used, two dimensional (2D) perturbations (hill and valley) and three-dimensional (3D) perturbations (egg crate pattern). The targets were subjected to dynamic loading using the Janus laser at the Jupiter Laser Facility. Shock pressures ranged from 50 GPa up to 150 GPa and were calibrated using VISAR drive targets.

  5. Photometric and Kinematic Studies of Extragalactic Globular Cluster Systems

    NASA Astrophysics Data System (ADS)

    Windschitl-Dowell, Jessica L.

    2015-01-01

    Globular clusters (GCs) are compact, luminous collections of stars created during the early stages of galaxy formation. As a result, the properties of GC systems provide important clues about the formation, merger history, and structure of their host galaxies. In particular, kinematic studies of GCs can be used to investigate the dark matter distribution in galaxy halos and provide observational evidence that can be used to constrain models of galaxy formation. I will present our study of the GC systems of two spiral galaxies, NGC 891 and NGC 1055, and show how we used wide-field BVR imaging from the WIYN 3.5-m telescope to detect the GC population and measure the global properties of the system. We quantified the radial distribution of the GC system and total number of GCs in these galaxies and compared the results to those of other galaxies.I will also present the results of spectroscopic follow-up for two giant galaxies: the S0 galaxy NGC 4594 (M104), and the elliptical galaxy NGC 3379 (M105). Using spectra taken with AAT/AAOmega, WIYN/HYDRA, and MMT/Hectospec, I measured the radial velocities of GCs, and combined them with published results to determine the mass distribution and V-band mass-to-light (M/LV) ratio profile for each galaxy out to large effective radius (7-9 Re). I compared our results to mass estimates from other kinematic tracers and also considered them in the context of galaxy formation models. For both galaxies, I found that the M/LV profiles increase with radius and do not flatten, which suggests that the dark matter halos in these galaxies extend to the edge of our data. I also looked for evidence of rotation within the GC systems, and found that neither system exhibits significant rotation around the host galaxy. Finally, I examined the velocity dispersion of each GC system as a function of radius and found kinematic differences between the red, metal-rich and blue, metal-poor GC subpopulations.

  6. 3D printed facial laser scans for the production of localised radiotherapy treatment masks - A case study.

    PubMed

    Briggs, Matthew; Clements, Helen; Wynne, Neil; Rennie, Allan; Kellett, Darren

    This study investigates the use of 3D printing for patients that require localised radiotherapy treatment to the face. The current process involves producing a lead mask in order to protect the healthy tissue from the effects of the radiotherapy. The mask is produced by applying a thermoplastic sheet to the patient's face and allowing to set hard. This can then be used as a mould to create a plaster impression of the patient's face. A sheet of lead is then hammered on to the plaster to create a bespoke fitted face mask. This process can be distressing for patients and can be problematic when the patient is required to remain motionless for a prolonged time while the thermoplastic sets. In this study, a 1:1 scale 3D print of a patient's face was generated using a laser scanner. The lead was hammered directly on to the surface of the 3D print in order to create a bespoke fitted treatment mask. This eliminated the thermoplastic moulding stage and significantly reduced the time needed for the patient to be in clinic. The higher definition impression of the the face resulted in a more accurate, better fitting treatment mask.

  7. Enhanced 3D prestack depth imaging of broadband data from the South China Sea: a case study

    NASA Astrophysics Data System (ADS)

    Zhang, Hao; Xu, Jincheng; Li, Jinbo

    2016-08-01

    We present a case study of prestack depth imaging for data from the South China Sea using an enhanced work flow with cutting edge technologies. In the survey area, the presence of complex geologies such as carbonate pinnacles and gas pockets creates challenges for processing and imaging: the complex geometry of carbonates exhibits 3D effect for wave propagation; deriving velocity inside carbonates and gas pockets is difficult and laborious; and localised strong attenuation effect from gas pockets may lead to absorption and dispersion problems. In the course of developing the enhanced work flow to tackle these issues, the following processing steps have the most significant impact on improving the imaging quality: (1) 3D ghost wavefield attenuation, in particular to remove the ghost energy associated with complex structures; (2) 3D surface-related multiple elimination (SRME) to remove multiples, in particular multiples related to complex carbonate structures; (3) full waveform inversion (FWI) and tomography-based velocity model building, to derive a geologically plausible velocity model for imaging; (4) Q-tomography to estimate the Q model which describes the intrinsic attenuation of the subsurface media; (5) de-absorption prestack depth migration (Q-PSDM) to compensate the earth absorption and dispersion effect during imaging especially for the area below gas pockets. The case study with the data from the South China Sea shows that the enhanced work flow consisting of cutting edge technologies is effective when the complex geologies are present.

  8. Assessing quality of urban underground spaces by coupling 3D geological models: The case study of Foshan city, South China

    NASA Astrophysics Data System (ADS)

    Hou, Weisheng; Yang, Liang; Deng, Dongcheng; Ye, Jing; Clarke, Keith; Yang, Zhijun; Zhuang, Wenming; Liu, Jianxiong; Huang, Jichun

    2016-04-01

    Urban underground spaces (UUS), especially those containing natural resources that have not yet been utilized, have been recognized as important for future sustainable development in large cities. One of the key steps in city planning is to estimate the quality of urban underground space resources, since they are major determinants of suitable land use. Yet geological constraints are rarely taken into consideration in urban planning, nor are the uncertainties in the quality of the available assessments. Based on Fuzzy Set theory and the analytic hierarchy process, a 3D stepwise process for the quality assessment of geotechnical properties of natural resources in UUS is presented. The process includes an index system for construction factors; area partitioning; the extraction of geological attributes; the creation of a relative membership grade matrix; the evaluation of subject and destination layers; and indeterminacy analysis. A 3D geological model of the study area was introduced into the process that extracted geological attributes as constraints. This 3D geological model was coupled with borehole data for Foshan City, Guangdong province, South China, and the indeterminacies caused by the cell size and the geological strata constraints were analyzed. The results of the case study show that (1) a relatively correct result can be obtained if the cell size is near to the average sampling distance of the boreholes; (2) the constraints of the 3D geological model have a major role in establishing the UUS quality level and distribution, especially at the boundaries of the geological bodies; and (3) the assessment result is impacted by an interaction between the cell resolution and the geological model used.

  9. 3D element imaging using NSECT for the detection of renal cancer: a simulation study in MCNP

    NASA Astrophysics Data System (ADS)

    Viana, R. S.; Agasthya, G. A.; Yoriyaz, H.; Kapadia, A. J.

    2013-09-01

    This work describes a simulation study investigating the application of neutron stimulated emission computed tomography (NSECT) for noninvasive 3D imaging of renal cancer in vivo. Using MCNP5 simulations, we describe a method of diagnosing renal cancer in the body by mapping the 3D distribution of elements present in tumors using the NSECT technique. A human phantom containing the kidneys and other major organs was modeled in MCNP5. The element composition of each organ was based on values reported in literature. The two kidneys were modeled to contain elements reported in renal cell carcinoma (RCC) and healthy kidney tissue. Simulated NSECT scans were executed to determine the 3D element distribution of the phantom body. Elements specific to RCC and healthy kidney tissue were then analyzed to identify the locations of the diseased and healthy kidneys and generate tomographic images of the tumor. The extent of the RCC lesion inside the kidney was determined using 3D volume rendering. A similar procedure was used to generate images of each individual organ in the body. Six isotopes were studied in this work—32S, 12C, 23Na, 14N, 31P and 39K. The results demonstrated that through a single NSECT scan performed in vivo, it is possible to identify the location of the kidneys and other organs within the body, determine the extent of the tumor within the organ, and to quantify the differences between cancer and healthy tissue-related isotopes with p ≤ 0.05. All of the images demonstrated appropriate concentration changes between the organs, with some discrepancy observed in 31P, 39K and 23Na. The discrepancies were likely due to the low concentration of the elements in the tissue that were below the current detection sensitivity of the NSECT technique.

  10. A morpho-kinematic and spectroscopic study of the bipolar nebulae: M 2-9, Mz 3, and Hen 2-104

    NASA Astrophysics Data System (ADS)

    Clyne, N.; Akras, S.; Steffen, W.; Redman, M. P.; Gonçalves, D. R.; Harvey, E.

    2015-10-01

    Context. Complex bipolar shapes can be generated either as a planetary nebula or a symbiotic system. The origin of the material ionised by the white dwarf is very different in these two scenarios, and it complicates the understanding of the morphologies of planetary nebulae. Aims: The physical properties, structure, and dynamics of the bipolar nebulae, M 2-9, Mz 3, and Hen 2-104, are investigated in detail with the aim of understanding their nature, shaping mechanisms, and evolutionary history. Both a morpho-kinematic study and a spectroscopic analysis, can be used to more accurately determine the kinematics and nature of each nebula. Methods: Long-slit optical echelle spectra are used to investigate the morpho-kinematics of M 2-9, Mz 3, and Hen 2-104. The morpho-kinematic modelling software SHAPE is used to constrain both the morphology and kinematics of each nebula by means of detailed 3D models. Near-infrared (NIR) data, as well as optical, spectra are used to separate Galactic symbiotic-type nebulae from genuine planetary nebulae by means of a 2MASS J-H/H-Ks diagram and a λ4363/Hγ vs. λ5007/Hβ diagnostic diagram, respectively. Results: The best-fitted 3D models for M 2-9, Mz 3, and Hen 2-104 provide invaluable kinematical information on the expansion velocity of its nebular components by means of synthetic spectra. The observed spectra match up very well with the synthetic spectra for each model, thus showing that each model is tightly constrained both morphologically and kinematically. Kinematical ages of the different structures of M 2-9 and Mz 3 have also been determined. Both diagnostic diagrams show M 2-9 and Hen 2-104 to fall well within the category of having a symbiotic source, whereas Mz 3 borders the region of symbiotic and young planetary nebulae in the optical diagram but is located firmly in the symbiotic region of the NIR colour-colour diagram. The optical diagnostic diagram is shown to successfully separate the two types of nebulae, however

  11. 3D Spectroscopy in Astronomy

    NASA Astrophysics Data System (ADS)

    Mediavilla, Evencio; Arribas, Santiago; Roth, Martin; Cepa-Nogué, Jordi; Sánchez, Francisco

    2011-09-01

    Preface; Acknowledgements; 1. Introductory review and technical approaches Martin M. Roth; 2. Observational procedures and data reduction James E. H. Turner; 3. 3D Spectroscopy instrumentation M. A. Bershady; 4. Analysis of 3D data Pierre Ferruit; 5. Science motivation for IFS and galactic studies F. Eisenhauer; 6. Extragalactic studies and future IFS science Luis Colina; 7. Tutorials: how to handle 3D spectroscopy data Sebastian F. Sánchez, Begona García-Lorenzo and Arlette Pécontal-Rousset.

  12. Mandibular kinematics after orthognathic surgical treatment a pilot study.

    PubMed

    Sforza, Chiarella; Ugolini, Alessandro; Rocchetta, Davide; Galante, Domenico; Mapelli, Andrea; Giannì, Aldo Bruno

    2010-03-01

    We recorded three-dimensional mandibular movements, while the mouth was being opened and closed, using an optoelectronic motion analyser in 14 patients (5 skeletal Class II, 9 skeletal Class III) who were being assessed 7-49 months after orthognathic operations, and in 44 healthy subjects. All 14 patients had satisfactory healing on clinical examination, and function had been restored. Mandibular movement was divided into its rotational and translational components. On maximum mouth opening, the patients had significantly less total displacement of the mandibular interincisor point (p=0.05), and more mandibular movement that was explained by pure condylar rotation (p=0.006), than control subjects. There was no significant relation between maximum mouth opening and percentage rotation. While mandibular motion was well restored clinically by orthognathic surgery, the kinematics of the joint were modified. Larger studies and longitudinal investigations are necessary to appreciate the clinical relevance of the variations in condylar rotational and translational components.

  13. Biologic response of inguinal hernia prosthetics: a comparative study of conventional static meshes versus 3D dynamic implants.

    PubMed

    Amato, Giuseppe; Romano, Giorgio; Agrusa, Antonino; Marasa, Salvatore; Cocorullo, Gianfranco; Gulotta, Gaspare; Goetze, Thorsten; Puleio, Roberto

    2015-01-01

    Despite improvements in prosthetics and surgical techniques, the rate of complications following inguinal hernia repair remains high. Among these, discomfort and chronic pain have become a source of increasing concern among surgeons. Poor quality of tissue ingrowth, such as thin scar plates or shrinking scars-typical results with conventional static implants and plugs-may contribute to these adverse events. Recently, a new type of 3D dynamically responsive implant was introduced to the market. This device, designed to be placed fixation-free, seems to induce ingrowth of viable and structured tissue instead of regressive fibrotic scarring. To elucidate the differences in biologic response between the conventional static meshes and this 3D dynamically responsive implant, a histological comparison was planned. The aim of this study was to determine the quality of tissue incorporation in both types of implants excised after short, medium, and long periods post-implantation. The results showed large differences in the biologic responses between the two implant types. Histologically, the 3D dynamic implant showed development of tissue elements more similar to natural abdominal wall structures, such as the ingrowth of loose and well-hydrated connective tissue, well-formed vascular structures, elastic fibers, and mature nerves, with negligible or absent inflammatory response. All these characteristics were completely absent in the conventional static implants, where a persistent inflammatory reaction was associated with thin, hardened, and shrunken fibrotic scar formation. Consequently, as herniation is a degenerative process, the 3D dynamic implants, which induce regeneration of the typical groin components, seem to address its pathogenesis.

  14. SHEAR WAVE SEISMIC STUDY COMPARING 9C3D SV AND SH IMAGES WITH 3C3D C-WAVE IMAGES

    SciTech Connect

    John Beecherl; Bob A. Hardage

    2004-07-01

    The objective of this study was to compare the relative merits of shear-wave (S-wave) seismic data acquired with nine-component (9-C) technology and with three-component (3-C) technology. The original proposal was written as if the investigation would be restricted to a single 9-C seismic survey in southwest Kansas (the Ashland survey), on the basis of the assumption that both 9-C and 3-C S-wave images could be created from that one data set. The Ashland survey was designed as a 9-C seismic program. We found that although the acquisition geometry was adequate for 9-C data analysis, the source-receiver geometry did not allow 3-C data to be extracted on an equitable and competitive basis with 9-C data. To do a fair assessment of the relative value of 9-C and 3-C seismic S-wave data, we expanded the study beyond the Ashland survey and included multicomponent seismic data from surveys done in a variety of basins. These additional data were made available through the Bureau of Economic Geology, our research subcontractor. Bureau scientists have added theoretical analyses to this report that provide valuable insights into several key distinctions between 9-C and 3-C seismic data. These theoretical considerations about distinctions between 3-C and 9-C S-wave data are presented first, followed by a discussion of differences between processing 9-C common-midpoint data and 3-C common-conversion-point data. Examples of 9-C and 3-C data are illustrated and discussed in the last part of the report. The key findings of this study are that each S-wave mode (SH-SH, SV-SV, or PSV) involves a different subsurface illumination pattern and a different reflectivity behavior and that each mode senses a different Earth fabric along its propagation path because of the unique orientation of its particle-displacement vector. As a result of the distinct orientation of each mode's particle-displacement vector, one mode may react to a critical geologic condition in a more optimal way than do

  15. Dual-mode intracranial catheter integrating 3D ultrasound imaging and hyperthermia for neuro-oncology: feasibility study.

    PubMed

    Herickhoff, Carl D; Light, Edward D; Bing, Kristin F; Mukundan, Srinivasan; Grant, Gerald A; Wolf, Patrick D; Smith, Stephen W

    2009-04-01

    In this study, we investigated the feasibility of an intracranial catheter transducer with dual-mode capability of real-time 3D (RT3D) imaging and ultrasound hyperthermia, for application in the visualization and treatment of tumors in the brain. Feasibility is demonstrated in two ways: first by using a 50-element linear array transducer (17 mm x 3.1 mm aperture) operating at 4.4 MHz with our Volumetrics diagnostic scanner and custom, electrical impedance-matching circuits to achieve a temperature rise over 4 degrees C in excised pork muscle, and second, by designing and constructing a 12 Fr, integrated matrix and linear-array catheter transducer prototype for combined RT3D imaging and heating capability. This dual-mode catheter incorporated 153 matrix array elements and 11 linear array elements diced on a 0.2 mm pitch, with a total aperture size of 8.4 mm x 2.3 mm. This 3.64 MHz array achieved a 3.5 degrees C in vitro temperature rise at a 2 cm focal distance in tissue-mimicking material. The dual-mode catheter prototype was compared with a Siemens 10 Fr AcuNav catheter as a gold standard in experiments assessing image quality and therapeutic potential and both probes were used in an in vivo canine brain model to image anatomical structures and color Doppler blood flow and to attempt in vivo heating.

  16. The Representation of Cultural Heritage from Traditional Drawing to 3d Survey: the Case Study of Casamary's Abbey

    NASA Astrophysics Data System (ADS)

    Canciani, M.; Saccone, M.

    2016-06-01

    In 3D survey the aspects most discussed in the scientific community are those related to the acquisition of data from integrated survey (laser scanner, photogrammetric, topographic and traditional direct), rather than those relating to the interpretation of the data. Yet in the methods of traditional representation, the data interpretation, such as that of the philological reconstruction, constitutes the most important aspect. It is therefore essential in modern systems of survey and representation, filter the information acquired. In the system, based on the integrated survey that we have adopted, the 3D object, characterized by a cloud of georeferenced points, defined but their color values, defines the core of the elaboration. It allows to carry out targeted analysis, using section planes as a tool of selection and filtering data, comparable with those of traditional drawings. In the case study of the Abbey of Casamari (Veroli), one of the most important Cistercian Settlement in Italy, the survey made for an Agreement with the Ministry of Cultural Heritage and Activities and Tourism (MiBACT) and University of RomaTre, within the project "Accessment of the sismic safety of the state museum", the reference 3D model, consisting of the superposition and geo-references data from various surveys, is the tool with which yo develop representative models comparable to traditional ones. It provides the necessary spatial environment for drawing up plans and sections with a definition such as to develop thematic analysis related to phases of construction, state of deterioration and structural features.

  17. Docking, 3D-QSAR studies and in silico ADME prediction on c-Src tyrosine kinase inhibitors.

    PubMed

    Tintori, Cristina; Magnani, Matteo; Schenone, Silvia; Botta, Maurizio

    2009-03-01

    Docking simulations and three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis were performed on a wide set of c-Src inhibitors. The study was conducted using a structure-based alignment and by applying the GRID/GOLPE approach. The present 3D-QSAR investigation proved to be of good statistical value, displaying r(2), q(2) and cross-validation SDEP values of 0.94, 0.84 and 0.42, respectively. Moreover, such a model also proved to be capable of predicting the activities of an external test set of compounds. The availability of the 3D structure of the target made possible the interpretation of steric and electrostatic maps within the binding site environment and provided useful insight into the structural requirements for inhibitory activity against c-Src. Two regions whose occupation by hydrophobic portions of ligands would favourably affect the activity were clearly identified. Moreover, hydrogen bond interactions involving residues Met343, Asp406 and Ser347 emerged as playing a key role in determining the affinity of the active inhibitors toward c-Src. Furthermore, the inhibitors bearing a basic nitrogen provided enhanced potency through protonation and salt bridge formation with Asp350. A preliminary pharmacokinetic profile of the molecules under analysis was also drawn on the basis of Volsurf predictions.

  18. Combinative in vitro studies and computational model to predict 3D cell migration response to drug insult.

    PubMed

    Maffei, Joseph S; Srivastava, Jaya; Fallica, Brian; Zaman, Muhammad H

    2014-10-01

    The development of drugs to counter diseases related to cell migration has resulted in a multi-billion dollar endeavor. Unfortunately, few drugs have emerged from this effort highlighting the need for new methods to enhance assays to study, analyze and control cell migration. In response to this complex process, computational models have emerged as potent tools to describe migration providing a high throughput and low cost method. However, most models are unable to predict migration response to drug with direct application to in vitro experiments. In addition to this, no model to date has attempted to describe migration in response to drugs while incorporating simultaneously protein signaling, proteolytic activity, and 3D culture. In this paper, we describe an integrated computational approach, in conjunction with in vitro observations, to serve as a platform to accurately predict migration in 3D matrices incorporating the function of matrix metalloproteinases (MMPs) and their interaction with the Extracellular signal-related kinase (ERK) signaling pathway. Our results provide biological insight into how matrix density, MMP activity, integrin adhesions, and p-ERK expression all affect speed and persistence in 3D. Predictions from the model provide insight toward improving drug combinations to more effectively reduce both speed and persistence during migration and the role of integrin adhesions in motility. In this way our integrated platform provides future potential to streamline and improve throughput toward the testing and development of migration targeting drugs with tangible application to current in vitro assays.

  19. Use of 3-D magnetic resonance electrical impedance tomography in detecting human cerebral stroke: a simulation study*

    PubMed Central

    Gao, Nuo; Zhu, Shan-an; He, Bin

    2005-01-01

    We have developed a new three dimensional (3-D) conductivity imaging approach and have used it to detect human brain conductivity changes corresponding to acute cerebral stroke. The proposed Magnetic Resonance Electrical Impedance Tomography (MREIT) approach is based on the J-Substitution algorithm and is expanded to imaging 3-D subject conductivity distribution changes. Computer simulation studies have been conducted to evaluate the present MREIT imaging approach. Simulations of both types of cerebral stroke, hemorrhagic stroke and ischemic stroke, were performed on a four-sphere head model. Simulation results showed that the correlation coefficient (CC) and relative error (RE) between target and estimated conductivity distributions were 0.9245±0.0068 and 8.9997%±0.0084%, for hemorrhagic stroke, and 0.6748±0.0197 and 8.8986%±0.0089%, for ischemic stroke, when the SNR (signal-to-noise radio) of added GWN (Gaussian White Noise) was 40. The convergence characteristic was also evaluated according to the changes of CC and RE with different iteration numbers. The CC increases and RE decreases monotonously with the increasing number of iterations. The present simulation results show the feasibility of the proposed 3-D MREIT approach in hemorrhagic and ischemic stroke detection and suggest that the method may become a useful alternative in clinical diagnosis of acute cerebral stroke in humans. PMID:15822161

  20. Engineering Multi-scale Electrospun Structure for Integration into Architected 3-D Nanofibers for Cimex Annihilation: Fabrication and Mechanism Study

    NASA Astrophysics Data System (ADS)

    He, Shan; Zhang, Linxi; Liu, Ying; Rafailovich, Miriam; Garcia CenterPolymers at Engineered Interfaces Team

    In this study, engineered electrospun scaffolds with fibers oriented with designed curvature in three dimensions (3D) including the looped structure were developed based on the principle of electrostatic repulsion. Here we illustrate that 3D electrospun recycled polystyrene fibers could closely mimic the unique architectures of multi-direction and multi-layer nano-spiderweb. In contrast to virgin PS, the recycled PS (Dart Styrofoam) are known to contain zinc stearate which acts as a surfactant resulting in higher electrical charge and larger fiber curvature, hence, lower modulus. The surfactant, which is known to decrease the surface tension, may have also been effective at decreasing the confinement of the PS, where chain stretching was shown to occur, in response to the high surface tension at the air interface. Three dimensional flexible architecture with complex structures are shown to be necessary in order to block the motion of Cimex lectularius. Here we show how an engineered electrospun network of surfactant modified polymer fibers with calculated dimensions can be used to immobilize the insects. The mechanical response of the fibers has to be specifically tailored so that it is elastically deformed, without fracturing or flowing. Carefully controlling and tailoring the electrospinning parameters we can now utilize architected 3D nanofiber to create an environmental-friendly Cimex immobilization device which can lead to annihilation solution for all the other harmful insects.

  1. Study on Information Management for the Conservation of Traditional Chinese Architectural Heritage - 3d Modelling and Metadata Representation

    NASA Astrophysics Data System (ADS)

    Yen, Y. N.; Weng, K. H.; Huang, H. Y.

    2013-07-01

    After over 30 years of practise and development, Taiwan's architectural conservation field is moving rapidly into digitalization and its applications. Compared to modern buildings, traditional Chinese architecture has considerably more complex elements and forms. To document and digitize these unique heritages in their conservation lifecycle is a new and important issue. This article takes the caisson ceiling of the Taipei Confucius Temple, octagonal with 333 elements in 8 types, as a case study for digitization practise. The application of metadata representation and 3D modelling are the two key issues to discuss. Both Revit and SketchUp were appliedin this research to compare its effectiveness to metadata representation. Due to limitation of the Revit database, the final 3D models wasbuilt with SketchUp. The research found that, firstly, cultural heritage databasesmustconvey that while many elements are similar in appearance, they are unique in value; although 3D simulations help the general understanding of architectural heritage, software such as Revit and SketchUp, at this stage, could onlybe used tomodel basic visual representations, and is ineffective indocumenting additional critical data ofindividually unique elements. Secondly, when establishing conservation lifecycle information for application in management systems, a full and detailed presentation of the metadata must also be implemented; the existing applications of BIM in managing conservation lifecycles are still insufficient. Results of the research recommends SketchUp as a tool for present modelling needs, and BIM for sharing data between users, but the implementation of metadata representation is of the utmost importance.

  2. New 3D-Culture Approaches to Study Interactions of Bone Marrow Adipocytes with Metastatic Prostate Cancer Cells.

    PubMed

    Herroon, Mackenzie Katheryn; Diedrich, Jonathan Driscoll; Podgorski, Izabela

    2016-01-01

    Adipocytes are a major component of the bone marrow that can critically affect metastatic progression in bone. Understanding how the marrow fat cells influence growth, behavior, and survival of tumor cells requires utilization of in vitro cell systems that can closely mimic the physiological microenvironment. Herein, we present two new three-dimensional (3D) culture approaches to study adipocyte-tumor cell interactions in vitro. The first is a transwell-based system composed of the marrow-derived adipocytes in 3D collagen I gels and reconstituted basement membrane-overlayed prostate tumor cell spheroids. Tumor cells cultured under these 3D conditions are continuously exposed to adipocyte-derived factors, and their response can be evaluated by morphological and immunohistochemical analyses. We show via immunofluorescence analysis of metabolism-associated proteins that under 3D conditions tumor cells have significantly different metabolic response to adipocytes than tumor cells grown in 2D culture. We also demonstrate that this model allows for incorporation of other cell types, such as bone marrow macrophages, and utilization of dye-quenched collagen substrates for examination of proteolysis-driven responses to adipocyte- and macrophage-derived factors. Our second 3D culture system is designed to study tumor cell invasion toward the adipocytes and the consequent interaction between the two cell types. In this model, marrow adipocytes are separated from the fluorescently labeled tumor cells by a layer of collagen I. At designated time points, adipocytes are stained with BODIPY and confocal z-stacks are taken through the depth of the entire culture to determine the distance traveled between the two cell types over time. We demonstrate that this system can be utilized to study effects of candidate factors on tumor invasion toward the adipocytes. We also show that immunohistochemical analyses can be performed to evaluate the impact of direct interaction of prostate

  3. Europeana and 3D

    NASA Astrophysics Data System (ADS)

    Pletinckx, D.

    2011-09-01

    The current 3D hype creates a lot of interest in 3D. People go to 3D movies, but are we ready to use 3D in our homes, in our offices, in our communication? Are we ready to deliver real 3D to a general public and use interactive 3D in a meaningful way to enjoy, learn, communicate? The CARARE project is realising this for the moment in the domain of monuments and archaeology, so that real 3D of archaeological sites and European monuments will be available to the general public by 2012. There are several aspects to this endeavour. First of all is the technical aspect of flawlessly delivering 3D content over all platforms and operating systems, without installing software. We have currently a working solution in PDF, but HTML5 will probably be the future. Secondly, there is still little knowledge on how to create 3D learning objects, 3D tourist information or 3D scholarly communication. We are still in a prototype phase when it comes to integrate 3D objects in physical or virtual museums. Nevertheless, Europeana has a tremendous potential as a multi-facetted virtual museum. Finally, 3D has a large potential to act as a hub of information, linking to related 2D imagery, texts, video, sound. We describe how to create such rich, explorable 3D objects that can be used intuitively by the generic Europeana user and what metadata is needed to support the semantic linking.

  4. 3D visualization and quantification of bone and teeth mineralization for the study of osteo/dentinogenesis in mice models

    NASA Astrophysics Data System (ADS)

    Marchadier, A.; Vidal, C.; Ordureau, S.; Lédée, R.; Léger, C.; Young, M.; Goldberg, M.

    2011-03-01

    Research on bone and teeth mineralization in animal models is critical for understanding human pathologies. Genetically modified mice represent highly valuable models for the study of osteo/dentinogenesis defects and osteoporosis. Current investigations on mice dental and skeletal phenotype use destructive and time consuming methods such as histology and scanning microscopy. Micro-CT imaging is quicker and provides high resolution qualitative phenotypic description. However reliable quantification of mineralization processes in mouse bone and teeth are still lacking. We have established novel CT imaging-based software for accurate qualitative and quantitative analysis of mouse mandibular bone and molars. Data were obtained from mandibles of mice lacking the Fibromodulin gene which is involved in mineralization processes. Mandibles were imaged with a micro-CT originally devoted to industrial applications (Viscom, X8060 NDT). 3D advanced visualization was performed using the VoxBox software (UsefulProgress) with ray casting algorithms. Comparison between control and defective mice mandibles was made by applying the same transfer function for each 3D data, thus allowing to detect shape, colour and density discrepencies. The 2D images of transverse slices of mandible and teeth were similar and even more accurate than those obtained with scanning electron microscopy. Image processing of the molars allowed the 3D reconstruction of the pulp chamber, providing a unique tool for the quantitative evaluation of dentinogenesis. This new method is highly powerful for the study of oro-facial mineralizations defects in mice models, complementary and even competitive to current histological and scanning microscopy appoaches.

  5. Improving the management of multimorbidity in general practice: protocol of a cluster randomised controlled trial (The 3D Study)

    PubMed Central

    Chaplin, Katherine; Bower, Peter; Brookes, Sara; Fitzpatrick, Bridie; Guthrie, Bruce; Shaw, Alison; Mercer, Stewart; Rafi, Imran; Thorn, Joanna

    2016-01-01

    Introduction An increasing number of people are living with multimorbidity. The evidence base for how best to manage these patients is weak. Current clinical guidelines generally focus on single conditions, which may not reflect the needs of patients with multimorbidity. The aim of the 3D study is to develop, implement and evaluate an intervention to improve the management of patients with multimorbidity in general practice. Methods and analysis This is a pragmatic two-arm cluster randomised controlled trial. 32 general practices around Bristol, Greater Manchester and Glasgow will be randomised to receive either the ‘3D intervention’ or usual care. 3D is a complex intervention including components affecting practice organisation, the conduct of patient reviews, integration with secondary care and measures to promote change in practice organisation. Changes include improving continuity of care and replacing reviews of each disease with patient-centred reviews with a focus on patients' quality of life, mental health and polypharmacy. We aim to recruit 1383 patients who have 3 or more chronic conditions. This provides 90% power at 5% significance level to detect an effect size of 0.27 SDs in the primary outcome, which is health-related quality of life at 15 months using the EQ-5D-5L. Secondary outcome measures assess patient centredness, illness burden and treatment burden. The primary analysis will be a multilevel regression model adjusted for baseline, stratification/minimisation, clustering and important co-variables. Nested process evaluation will assess implementation, mechanisms of effectiveness and interaction of the intervention with local context. Economic analysis of cost-consequences and cost-effectiveness will be based on quality-adjusted life years. Ethics and dissemination This study has approval from South-West (Frenchay) National Health Service (NHS) Research Ethics Committee (14/SW/0011). Findings will be disseminated via final report, peer

  6. A Detailed Study of FDIRC Prototype with Waveform Digitizing Electronics in Cosmic Ray Telescope Using 3D Tracks.

    SciTech Connect

    Nishimura, K

    2012-07-01

    We present a detailed study of a novel Cherenkov imaging detector called the Focusing DIRC (FDIRC) with waveform digitizing electronics. In this test study, the FDIRC prototype has been instrumented with seven Hamamatsu H-8500 MaPMTs. Waveforms from ~450 pixels are digitized with waveform sampling electronics based on the BLAB2 ASIC, operating at a sampling speed of ~2.5 GSa/s. The FDIRC prototype was tested in a large cosmic ray telescope (CRT) providing 3D muon tracks with ~1.5 mrad angular resolution and muon energy of Emuon greater than 1.6 GeV. In this study we provide a detailed analysis of the tails in the Cherenkov angle distribution as a function of various variables, compare experimental results with simulation, and identify the major contributions to the tails. We demonstrate that to see the full impact of these tails on the Cherenkov angle resolution, it is crucial to use 3D tracks, and have a full understanding of the role of ambiguities. These issues could not be fully explored in previous FDIRC studies where the beam was perpendicular to the quartz radiator bars. This work is relevant for the final FDIRC prototype of the PID detector at SuperB, which will be tested this year in the CRT setup.

  7. A Detailed Study of FDIRC Prototype with Waveform Digitizing Electronics in Cosmic Ray Telescope Using 3D Tracks

    SciTech Connect

    Nishimura, K.; Dey, B.; Aston, D.; Leith, D.W.G.S.; Ratcliff, B.; Roberts, D.; Ruckman, L.; Shtol, D.; Varner, G.S.; Va'vra, J.; Vavra, Jerry; /SLAC

    2012-07-30

    We present a detailed study of a novel Cherenkov imaging detector called the Focusing DIRC (FDIRC) with waveform digitizing electronics. In this test study, the FDIRC prototype has been instrumented with seven Hamamatsu H-8500 MaPMTs. Waveforms from {approx}450 pixels are digitized with waveform sampling electronics based on the BLAB2 ASIC, operating at a sampling speed of {approx}2.5 GSa/s. The FDIRC prototype was tested in a large cosmic ray telescope (CRT) providing 3D muon tracks with {approx}1.5 mrad angular resolution and muon energy of E{sub muon} > 1.6 GeV. In this study we provide a detailed analysis of the tails in the Cherenkov angle distribution as a function of various variables, compare experimental results with simulation, and identify the major contributions to the tails. We demonstrate that to see the full impact of these tails on the Cherenkov angle resolution, it is crucial to use 3D tracks, and have a full understanding of the role of ambiguities. These issues could not be fully explored in previous FDIRC studies where the beam was perpendicular to the quartz radiator bars. This work is relevant for the final FDIRC prototype of the PID detector at SuperB, which will be tested this year in the CRT setup.

  8. Sensitivity Studies of 3D Geothermal Reservoir Simulation: A Case Study in I-Lan Plain, Taiwan

    NASA Astrophysics Data System (ADS)

    Kuo, C. W.; Song, S. R.

    2015-12-01

    A large scale geothermal project conducted by Ministry of Science and Technology is initiated recently in I-Lan south area, northeastern Taiwan. The ultimate goal of this national project is to increase the percentage of renewable energy (ex. geothermal energy) to generate electricity. An integrated team which consists of various specialties are held together to investigate I-Lan area comprehensively. For example, I-Lan geological data, petrophysical analysis, seismicity, temperature gradient and distribution, hydrology, geochemistry, and heat source study etc. The geothermal gradient measured at one drilling well (1200m deep) is up to 50˚C/km and the prediction of temperature based on fluid inclusion analysis could be up to 300˚C. The geothermal reservoir is expected to occur at a fractured geological formation, Siling sandstone layer. A 3D subsurface geological model is built mainly based on the seismic exploration of the subsurface structure and well log data. According to the current conceptual model, the target area is bounded by two main faults, Jiaosi and Choshui faults. The preliminary results from all the investigations are integrated and used as input parameters to create a realistic numerical reservoir model. Numerical simulator TOUGH2 is used to study the geothermal energy potential. The initial state of temperature distribution is simulated and compared to the high resolution of magnetotelluric (MT) data. Simulation results show that they have similar pattern and therefore the prediction of geothermal potential in this area would be more reliable. Based on the realistic initial state, sensitivity studies are performed to investigate effects of relevant parameters on temperature distribution.

  9. Comments and corrections on 3D modeling studies of locomotor muscle moment arms in archosaurs

    PubMed Central

    Maidment, Susannah C.R.; Schachner, Emma R.; Barrett, Paul M.

    2015-01-01

    In a number of recent studies we used computer modeling to investigate the evolution of muscle leverage (moment arms) and function in extant and extinct archosaur lineages (crocodilians, dinosaurs including birds and pterosaurs). These studies sought to quantify the level of disparity and convergence in muscle moment arms during the evolution of bipedal and quadrupedal posture in various independent archosaur lineages, and in doing so further our understanding of changes in anatomy, locomotion and ecology during the group’s >250 million year evolutionary history. Subsequent work by others has led us to re-evaluate our models, which revealed a methodological error that impacted on the results obtained from the abduction–adduction and long-axis rotation moment arms in our published studies. In this paper we present corrected abduction–adduction and long axis rotation moment arms for all our models, and evaluate the impact of this new data on the conclusions of our previous studies. We find that, in general, our newly corrected data differed only slightly from that previously published, with very few qualitative changes in muscle moments (e.g., muscles originally identified as abductors remained abductors). As a result the majority of our previous conclusions regarding the functional evolution of key muscles in these archosaur groups are upheld. PMID:26500810

  10. 3D technology of Sony Bloggie has no advantage in decision-making of tennis serve direction: A randomized placebo-controlled study.

    PubMed

    Liu, Sicong; Ritchie, Jason; Sáenz-Moncaleano, Camilo; Ward, Savanna K; Paulsen, Cody; Klein, Tyler; Gutierrez, Oscar; Tenenbaum, Gershon

    2017-06-01

    This study aimed at exploring whether 3D technology enhances tennis decision-making under the conceptual framework of human performance model. A 3 (skill-level: varsity, club, recreational) × 3 (experimental condition: placebo, weak 3D [W3D], strong 3D [S3D]) between-participant design was used. Allocated to experimental conditions by a skill-level stratified randomization, 105 tennis players judged tennis serve direction from video scenarios and rated their perceptions of enjoyment, flow, and presence during task performance. Results showed that varsity players made more accurate decisions than less skilled ones. Additionally, applying 3D technology to typical video displays reduced tennis players' decision-making accuracy, although wearing the 3D glasses led to a placebo effect that shortened the decision-making reaction time. The unexpected negative effect of 3D technology on decision-making was possibly due to participants being more familiar to W3D than to S3D, and relatedly, a suboptimal task-technology match. Future directions for advancing this area of research are offered. Highlights 3D technology augments binocular depth cues to tradition video displays, and thus results in the attainment of more authentic visual representation. This process enhances task fidelity in researching perceptual-cognitive skills in sports. The paper clarified both conceptual and methodological difficulties in testing 3D technology in sports settings. Namely, the nomenclature of video footage (with/without 3D technology) and the possible placebo effect (arising from wearing glasses of 3D technology) merit researchers' attention. Participants varying in level of domain-specific expertise were randomized into viewing conditions using a placebo-controlled design. Measurement consisted of both participants' subjective experience (i.e., presence, flow, and enjoyment) and objective performance (i.e., accuracy and reaction time) in a decision-making task. Findings revealed that

  11. Numerical study of 3-D inducer and impeller for pump model development

    NASA Astrophysics Data System (ADS)

    Cheng, G. C.; Chen, Y. S.; Garcia, R.; Williams, R. W.

    1993-07-01

    Current design of high-performance turbopumps for rocket engines requires effective and robust analytical tools to provide design information in a productive manner. The main goal of this study is to develop a robust and effective CFD pump model for general turbopump design and analysis applications. A finite difference Navier-Stokes flow solver, FDNS, which includes an extended k-epsilon turbulence model and appropriate moving zonal interface boundary conditions, was developed to analyze turbulent flows in turbomachinery devices. In the present study, two key components of the turbopump, the inducer and impeller, were investigated by the proposed pump model, and the numerical results were benchmarked by the experimental data provided by Rocketdyne.

  12. Numerical study of 3-D inducer and impeller for pump model development

    NASA Technical Reports Server (NTRS)

    Cheng, G. C.; Chen, Y. S.; Garcia, R.; Williams, R. W.

    1993-01-01

    Current design of high-performance turbopumps for rocket engines requires effective and robust analytical tools to provide design information in a productive manner. The main goal of this study is to develop a robust and effective CFD pump model for general turbopump design and analysis applications. A finite difference Navier-Stokes flow solver, FDNS, which includes an extended k-epsilon turbulence model and appropriate moving zonal interface boundary conditions, was developed to analyze turbulent flows in turbomachinery devices. In the present study, two key components of the turbopump, the inducer and impeller, were investigated by the proposed pump model, and the numerical results were benchmarked by the experimental data provided by Rocketdyne.

  13. 3D-printed microfluidic microdissector for high-throughput studies of cellular aging.

    PubMed

    Spivey, Eric C; Xhemalce, Blerta; Shear, Jason B; Finkelstein, Ilya J

    2014-08-05

    Due to their short lifespan, rapid division, and ease of genetic manipulation, yeasts are popular model organisms for studying aging in actively dividing cells. To study replicative aging over many cell divisions, individual cells must be continuously separated from their progeny via a laborious manual microdissection procedure. Microfluidics-based soft-lithography devices have recently been used to automate microdissection of the budding yeast Saccharomyces cerevisiae. However, little is known about replicative aging in Schizosaccharomyces pombe, a rod-shaped yeast that divides by binary fission and shares many conserved biological functions with higher eukaryotes. In this report, we develop a versatile multiphoton lithography method that enables rapid fabrication of three-dimensional master structures for polydimethylsiloxane (PDMS)-based microfluidics. We exploit the rapid prototyping capabilities of multiphoton lithography to create and characterize a cell-capture device that is capable of high-resolution microscopic observation of hundreds of individual S. pombe cells. By continuously removing the progeny cells, we demonstrate that cell growth and protein aggregation can be tracked in individual cells for over ~100 h. Thus, the fission yeast lifespan microdissector (FYLM) provides a powerful on-chip microdissection platform that will enable high-throughput studies of aging in rod-shaped cells.

  14. High-frequency 3D echodentographic imaging modality for early assessment of periodontal diseases: in vitro study

    NASA Astrophysics Data System (ADS)

    Mahmoud, Ahmed M.; Ngan, Peter; Crout, Richard; Mukdadi, Osama M.

    2009-02-01

    The use of ultrasound in dentistry is still an open growing area of research. Currently, there is a lack of imaging modalities to accurately predict minute structures and defects in the jawbone. In particular, the inability of 2D radiographic images to detect bony periodontal defects resulted from infection of the periodontium. This study investigates the feasibility of high frequency ultrasound to reconstruct high resolution 3D surface images of human jawbone. Methods: A dentate and non-dentate mandibles were used in this study. The system employs high frequency single-element ultrasound focused transducers (15-30 MHz) for scanning. Continuous acquisition using a 1 GHz data acquisition card is synchronized with a high precision two-dimensional stage positioning system of +/-1 μm resolution for acquiring accurate and quantitative measurements of the mandible in vitro. Radio frequency (RF) signals are acquired laterally 44-45.5 μm apart for each frame. Different frames are reconstructed 500 μm apart for the 3D reconstruction. Signal processing algorithms are applied on the received ultrasound signals for filtering, focusing, and envelope detection before frame reconstruction. Furthermore, an edge detection technique is adopted to detect the bone surface in each frame. Finally, all edges are combined together in order to render a 3D surface image of the jawbone. Major anatomical landmarks on the resultant images were confirmed with the anatomical structures on the mandibles to show the efficacy of the system. Comparison were also made with conventional 2D radiographs to show the superiority of the ultrasound imaging system in diagnosing small defects in the lateral, axial and elevation planes of space. Results: The landmarks on all ultrasound images matched with those on the mandible, indicating the efficacy of the system in detecting small structures in human jaw bones. Comparison with conventional 2D radiographic images of the same mandible showed superiority of

  15. Benchmark Study of 3D Pore-scale Flow and Solute Transport Simulation Methods

    NASA Astrophysics Data System (ADS)

    Scheibe, T. D.; Yang, X.; Mehmani, Y.; Perkins, W. A.; Pasquali, A.; Schoenherr, M.; Kim, K.; Perego, M.; Parks, M. L.; Trask, N.; Balhoff, M.; Richmond, M. C.; Geier, M.; Krafczyk, M.; Luo, L. S.; Tartakovsky, A. M.

    2015-12-01

    Multiple numerical approaches have been developed to simulate porous media fluid flow and solute transport at the pore scale. These include 1) methods that explicitly model the three-dimensional geometry of pore spaces and 2) methods that conceptualize the pore space as a topologically consistent set of stylized pore bodies and pore throats. In previous work we validated a model of the first type, using computational fluid dynamics (CFD) codes employing standard finite volume method (FVM), against magnetic resonance velocimetry (MRV) measurements of pore-scale velocities. Here we expand that benchmark study to include additional models of the first type based on the immersed-boundary method (IMB), lattice Boltzmann method (LBM), and smoothed particle hydrodynamics (SPH), as well as a model of the second type, a pore-network model (PNM). While the PNM approach is computationally much less demanding than direct numerical simulation methods, the effect of conceptualizing complex three-dimensional pore geometries in the manner of PNMs has not been fully determined. We apply all five approaches (FVM-based CFD, IMB, LBM, SPH and PNM) to simulate pore-scale velocity distributions and nonreactive solute transport, and intercompare the model results. Comparisons are drawn both in terms of macroscopic variables (e.g., permeability, solute breakthrough curves) and microscopic variables (e.g., local velocities and concentrations). Generally good agreement was achieved among the various approaches, but some differences were observed depending on the model context. The benchmark study was challenging because of variable capabilities of the codes, and inspired some code enhancements to allow consistent comparison of flow and transport simulations across the full suite of methods. This study provides support for confidence in a variety of pore-scale modeling methods, and motivates further development and application of pore-scale simulation methods.

  16. Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study

    PubMed Central

    Lim, Jong-Min; Bertrand, Nicolas; Valencia, Pedro M.; Rhee, Minsoung; Langer, Robert; Jon, Sangyong; Farokhzad, Omid C.; Karnik, Rohit

    2014-01-01

    Microfluidic synthesis of nanoparticles (NPs) can enhance the controllability and reproducibility in physicochemical properties of NPs compared to bulk synthesis methods. However, applications of microfluidic synthesis are typically limited to in vitro studies due to low production rates. Herein, we report the parallelization of NP synthesis by 3D hydrodynamic flow focusing (HFF) using a multilayer microfluidic system to enhance the production rate without losing the advantages of reproducibility, controllability, and robustness. Using parallel 3D HFF, polymeric poly(lactide-co-glycolide)-b-polyethyleneglycol (PLGA-PEG) NPs with sizes tunable in the range of 13–150 nm could be synthesized reproducibly with high production rate. As a proof of concept, we used this system to perform in vivo pharmacokinetic and biodistribution study of small (20 nm diameter) PLGA-PEG NPs that are otherwise difficult to synthesize. Microfluidic parallelization thus enables synthesis of NPs with tunable properties with production rates suitable for both in vitro and in vivo studies. PMID:23969105

  17. Simultaneous real-time 3D photoacoustic tomography and EEG for neurovascular coupling study in an animal model of epilepsy

    NASA Astrophysics Data System (ADS)

    Wang, Bo; Xiao, Jiaying; Jiang, Huabei

    2014-08-01

    Objective. Neurovascular coupling in epilepsy is poorly understood; its study requires simultaneous monitoring of hemodynamic changes and neural activity in the brain. Approach. Here for the first time we present a combined real-time 3D photoacoustic tomography (PAT) and electrophysiology/electroencephalography (EEG) system for the study of neurovascular coupling in epilepsy, whose ability was demonstrated with a pentylenetetrazol (PTZ) induced generalized seizure model in rats. Two groups of experiments were carried out with different wavelengths to detect the changes of oxy-hemoglobin (HbO2) and deoxy-hemoglobin (HbR) signals in the rat brain. We extracted the average PAT signals of the superior sagittal sinus (SSS), and compared them with the EEG signal. Main results. Results showed that the seizure process can be divided into three stages. A ‘dip’ lasting for 1-2 min in the first stage and the following hyperfusion in the second stage were observed. The HbO2 signal and the HbR signal were generally negatively correlated. The change of blood flow was also estimated. All the acquired results here were in accordance with other published results. Significance. Compared to other existing functional neuroimaging tools, the method proposed here enables reliable tracking of hemodynamic signal with both high spatial and high temporal resolution in 3D, so it is more suitable for neurovascular coupling study of epilepsy.

  18. A single particle plasmon resonance study of 3D conical nanoantennas.

    PubMed

    Schäfer, Christian; Gollmer, Dominik A; Horrer, Andreas; Fulmes, Julia; Weber-Bargioni, Alexander; Cabrini, Stefano; Schuck, P James; Kern, Dieter P; Fleischer, Monika

    2013-09-07

    Metallic nanocones are well-suited optical antennas for near-field microscopy and spectroscopy, exhibiting a number of different plasmonic modes. A major challenge in using nanocones for many applications is maximizing the signal at the tip while minimizing the background from the base. It is shown that nanocone plasmon resonance properties can be shifted over a wide range of wavelengths by variation of the substrate, material, size and shape, enabling potential control over specific modes and field distributions. The individual resonances are identified and studied by correlated single particle dark field scattering and scanning electron microscopy in combination with numerical simulations.

  19. [Experimental study of the collagen matrix for increase the gums using a 3D-modeling].

    PubMed

    Baulin, I M; Badalyan, V A; Ryakhovsky, A N

    2015-01-01

    In an experimental study on mini-pigs demonstrated that the use of collagen matrix Mucograft open method leads to the formation of mature connective tissue around the implants, more pronounced after 70 days, and the width of attached mucosa already 45th day (from 4.4 ± 0.3 to 7.7 ± 0.5 mm) is comparable to that of free gingival graft. Three-dimensional computer modeling of jaws experimental animals showed the soft tissue augmentation by 0.8 ± 0.1 cm3 after use of collagen matrix Mucograft and 1.1 ± 0.12 cm3 after free gingival graft.

  20. Molecular docking and 3D-QSAR studies on gag peptide analogue inhibitors interacting with human cyclophilin A.

    PubMed

    Cui, Meng; Huang, Xiaoqin; Luo, Xiaomin; Briggs, James M; Ji, Ruyun; Chen, Kaixian; Shen, Jianhua; Jiang, Hualiang

    2002-11-21

    The interaction of a series gag peptide analogues with human cyclophilin A (hCypA) have been studied employing molecular docking and 3D-QSAR approaches. The Lamarckian Genetic Algorithm (LGA) and divide-and-conquer methods were applied to locate the binding orientations and conformations of the inhibitors interacting with hCypA. Good correlations between the calculated interaction free energies and experimental inhibitory activities suggest that the binding conformations of these inhibitors are reasonable. A novel interaction model was identified for inhibitors 11, 15, and 17 whose N-termini were modified by addition of the deaminovaline (Dav) group and the C-termini of 15 and 17 were modified by addition of a benzyl group. Accordingly, two new binding sites (sites A and D in Figure 1) were revealed, which show a strong correlation with inhibitor potency and thus can be used as a starting point for new inhibitor design. In addition, two predictive 3D-QSAR models were obtained by CoMFA and CoMSIA analyses based on the binding conformations derived from the molecular docking calculations. The reasonable r(cross)(2) (cross-validated) values 0.738 and 0.762 were obtained for CoMFA and CoMSIA models, respectively. The predictive ability of these models was validated by four peptide analogues test set. The CoMFA and CoMSIA field distributions are in general agreement with the structural characteristics of the binding groove of hCypA. This indicates the reasonableness of the binding model of the inhibitors with hCypA. Considering all these results together with the valuable clues of binding from references published recently, reasonable pharmacophore elements have been suggested, demonstrating that the 3D-QSAR models a