Science.gov

Sample records for 3rd generation 3g

  1. 2nd & 3rd Generation Vehicle Subsystems

    NASA Technical Reports Server (NTRS)

    2000-01-01

    This paper contains viewgraph presentation on the "2nd & 3rd Generation Vehicle Subsystems" project. The objective behind this project is to design, develop and test advanced avionics, power systems, power control and distribution components and subsystems for insertion into a highly reliable and low-cost system for a Reusable Launch Vehicles (RLV). The project is divided into two sections: 3rd Generation Vehicle Subsystems and 2nd Generation Vehicle Subsystems. The following topics are discussed under the first section, 3rd Generation Vehicle Subsystems: supporting the NASA RLV program; high-performance guidance & control adaptation for future RLVs; Evolvable Hardware (EHW) for 3rd generation avionics description; Scaleable, Fault-tolerant Intelligent Network or X(trans)ducers (SFINIX); advance electric actuation devices and subsystem technology; hybrid power sources and regeneration technology for electric actuators; and intelligent internal thermal control. Topics discussed in the 2nd Generation Vehicle Subsystems program include: design, development and test of a robust, low-maintenance avionics with no active cooling requirements and autonomous rendezvous and docking systems; design and development of a low maintenance, high reliability, intelligent power systems (fuel cells and battery); and design of a low cost, low maintenance high horsepower actuation systems (actuators).

  2. Precipitation Model Validation in 3rd Generation Aeroturbine Disc Alloys

    NASA Technical Reports Server (NTRS)

    Olson, G. B.; Jou, H.-J.; Jung, J.; Sebastian, J. T.; Misra, A.; Locci, I.; Hull, D.

    2008-01-01

    In support of application of the DARPA-AIM methodology to the accelerated hybrid thermal process optimization of 3rd generation aeroturbine disc alloys with quantified uncertainty, equilibrium and diffusion couple experiments have identified available fundamental thermodynamic and mobility databases of sufficient accuracy. Using coherent interfacial energies quantified by Single-Sensor DTA nucleation undercooling measurements, PrecipiCalc(TM) simulations of nonisothermal precipitation in both supersolvus and subsolvus treated samples show good agreement with measured gamma particle sizes and compositions. Observed longterm isothermal coarsening behavior defines requirements for further refinement of elastic misfit energy and treatment of the parallel evolution of incoherent precipitation at grain boundaries.

  3. Designing a 3rd generation, authenticatable attribute measurement system

    SciTech Connect

    Thron, Jonathan; Karpius, Peter; Santi, Peter; Smith, Morag; Vo, Duc; Williams, Richard

    2009-01-01

    Attribute measurement systems (AMS) are designed to measure potentially sensitive items containing Special Nuclear Materials to determine if the items possess attributes which fall within an agreed-upon range. Such systems could be used in a treaty to inspect and verify the identity of items in storage without revealing any sensitive information associated with the item. An AMS needs to satisfy two constraints: the host party needs to be sure that none of their sensitive information is released, while the inspecting party wants to have confidence that the limited amount of information they see accurately reflects the properties of the item being measured. The former involves 'certifying' the system and the latter 'authenticating' it. Previous work into designing and building AMS systems have focused more on the questions of certifiability than on the questions of authentication - although a few approaches have been investigated. The next step is to build a 3rd generation AMS which (1) makes the appropriate measurements, (2) can be certified, and (3) can be authenticated (the three generations). This paper will discuss the ideas, options, and process of producing a design for a 3rd generation AMS.

  4. Microstructure Modeling of 3rd Generation Disk Alloys

    NASA Technical Reports Server (NTRS)

    Jou, Herng-Jeng

    2010-01-01

    The objective of this program is to model, validate, and predict the precipitation microstructure evolution, using PrecipiCalc (QuesTek Innovations LLC) software, for 3rd generation Ni-based gas turbine disc superalloys during processing and service, with a set of logical and consistent experiments and characterizations. Furthermore, within this program, the originally research-oriented microstructure simulation tool will be further improved and implemented to be a useful and user-friendly engineering tool. In this report, the key accomplishment achieved during the second year (2008) of the program is summarized. The activities of this year include final selection of multicomponent thermodynamics and mobility databases, precipitate surface energy determination from nucleation experiment, multiscale comparison of predicted versus measured intragrain precipitation microstructure in quench samples showing good agreement, isothermal coarsening experiment and interaction of grain boundary and intergrain precipitates, primary microstructure of subsolvus treatment, and finally the software implementation plan for the third year of the project. In the following year, the calibrated models and simulation tools will be validated against an independently developed experimental data set, with actual disc heat treatment process conditions. Furthermore, software integration and implementation will be developed to provide material engineers valuable information in order to optimize the processing of the 3rd generation gas turbine disc alloys.

  5. Results from the UK 3rd generation programme: Albion

    NASA Astrophysics Data System (ADS)

    McEwen, R. K.; Axcell, C.; Knowles, P.; Hoade, K. P.; Wilson, M.; Dennis, P. N. J.; Backhouse, P.; Gordon, N. T.

    2008-10-01

    Following the development of 1st Generation systems in the 1970s, thermal imaging has been in service with the UK armed forces for over 25 years and has proven itself to be a battle winning technology. More recently the wider accessibility to similar technologies within opposing forces has reduced the military advantage provided by these 1st Generation systems and a clear requirement has been identified by the UK MOD for thermal imaging sensors providing increased detection, recognition and identification (DRI) ranges together with a simplified logistical deployment burden and reduced through-life costs. In late 2005, the UK MOD initiated a programme known as "Albion" to develop high performance 3rd Generation single waveband infrared detectors to meet this requirement. At the same time, under a separate programme supporting higher risk technology, a dual waveband infrared detector was also developed. The development phase of the Albion programme has now been completed and prototype detectors are now available and have been integrated into demonstration thermal imaging cameras. The Albion programme has now progressed into the second phase, incorporating both single and dual waveband devices, focussing on low rate initial production (LRIP) and qualification of the devices for military applications. All of the detectors have been fabricated using cadmium mercury telluride material (CMT), grown by metal organic vapour phase epitaxy (MOVPE) on low cost, gallium arsenide (GaAs) substrates and bump bonded to the silicon read out circuit (ROIC). This paper discusses the design features of the 3rd Generation detectors developed in the UK together with the results obtained from the prototype devices both in the laboratory and when integrated into field deployable thermal imaging cameras.

  6. Deployment simulation for 3rd generation solar array GSR3

    NASA Astrophysics Data System (ADS)

    Verne, C.; Rouchon, M.

    1989-01-01

    Deployment tests for different solar arrays are described. The Spacebus solar array deployment is tested in two dimensions. The Spot 4 array deployment is tested in three dimensions. A mock-up deployment test on an air cushion is compared to results obtained using simulation software. The third generation solar array concept equipped with Adele hinges is compared to previous solar array models. The need for greater accuracy and reliability in the deployment analysis of these third generation solar arrays is stressed.

  7. IVHM for the 3rd Generation RLV Program: Technology Development

    NASA Technical Reports Server (NTRS)

    Kahle, Bill

    2000-01-01

    The objective behind the Integrated Vehicle Health Management (IVHM) project is to develop and integrate the technologies which can provide a continuous, intelligent, and adaptive health state of a vehicle and use this information to improve safety and reduce costs of operations. Technological areas discussed include: developing, validating, and transfering next generation IVHM technologies to near term industry and government reusable launch systems; focus NASA on the next generation and highly advanced sensor and software technologies; and validating IVHM systems engineering design process for future programs.

  8. Structures for the 3rd Generation Reusable Concept Vehicle

    NASA Technical Reports Server (NTRS)

    Hrinda, Glenn A.

    2001-01-01

    A major goal of NASA is to create an advance space transportation system that provides a safe, affordable highway through the air and into space. The long-term plans are to reduce the risk of crew loss to 1 in 1,000,000 missions and reduce the cost of Low-Earth Orbit by a factor of 100 from today's costs. A third generation reusable concept vehicle (RCV) was developed to assess technologies required to meet NASA's space access goals. The vehicle will launch from Cape Kennedy carrying a 25,000 lb. payload to the International Space Station (ISS). The system is an air breathing launch vehicle (ABLV) hypersonic lifting body with rockets and uses triple point hydrogen and liquid oxygen propellant. The focus of this paper is on the structural concepts and analysis methods used in developing the third generation reusable launch vehicle (RLV). Member sizes, concepts and material selections will be discussed as well as analysis methods used in optimizing the structure. Analysis based on the HyperSizer structural sizing software will be discussed. Design trades required to optimize structural weight will be presented.

  9. Microstructure Modeling of 3rd Generation Disk Alloy

    NASA Technical Reports Server (NTRS)

    Jou, Herng-Jeng

    2008-01-01

    The objective of this initiative, funded by NASA's Aviation Safety Program, is to model, validate, and predict, with high fidelity, the microstructural evolution of third-generation high-refractory Ni-based disc superalloys during heat treating and service conditions. This initiative is a natural extension of the DARPA-AIM (Accelerated Insertion of Materials) initiative with GE/Pratt-Whitney and with other process simulation tools. Strong collaboration with the NASA Glenn Research Center (GRC) is a key component of this initiative and the focus of this program is on industrially relevant disk alloys and heat treatment processes identified by GRC. Employing QuesTek s Computational Materials Dynamics technology and PrecipiCalc precipitation simulator, physics-based models are being used to achieve high predictive accuracy and precision. Combining these models with experimental data and probabilistic analysis, "virtual alloy design" can be performed. The predicted microstructures can be optimized to promote desirable features and concurrently eliminate nondesirable phases that can limit the reliability and durability of the alloys. The well-calibrated and well-integrated software tools that are being applied under the proposed program will help gas turbine disk alloy manufacturers, processing facilities, and NASA, to efficiently and effectively improve the performance of current and future disk materials.

  10. The Goodrich 3rd generation DB-110 system: successful flight test on the F-16 aircraft

    NASA Astrophysics Data System (ADS)

    Lange, Davis; Iyengar, Mrinal; Maver, Larry; Dyer, Gavin; Francis, John

    2007-04-01

    The 3rd Generation Goodrich DB-110 system provides users with a three (3) field-of-view high performance Airborne Reconnaissance capability that incorporates a dual-band day and nighttime imaging sensor, a real time recording and a real time data transmission capability to support long range, medium range, and short range standoff and over-flight mission scenarios, all within a single pod. Goodrich developed their 3rd Generation Airborne Reconnaissance Pod for operation on a range of aircraft types including F-16, F-15, F-18, Euro-fighter and older aircraft such as the F-4, F-111, Mirage and Tornado. This system upgrades the existing, operationally proven, 2nd generation DB-110 design with enhancements in sensor resolution, flight envelope and other performance improvements. Goodrich recently flight tested their 3rd Generation Reconnaissance System on a Block 52 F-16 aircraft with first flight success and excellent results. This paper presents key highlights of the system and presents imaging results from flight test.

  11. Recent advances on developing 3rd generation enzyme electrode for biosensor applications.

    PubMed

    Das, Priyanki; Das, Madhuri; Chinnadayyala, Somasekhar R; Singha, Irom Manoj; Goswami, Pranab

    2016-05-15

    The electrochemical biosensor with enzyme as biorecognition element is traditionally pursued as an attractive research topic owing to their high commercial perspective in healthcare and environmental sectors. The research interest on the subject is sharply increased since the beginning of 21st century primarily, due to the concomitant increase in knowledge in the field of material science. The remarkable effects of many advance materials such as, conductive polymers and nanomaterials, were acknowledged in the developing efficient 3rd generation enzyme bioelectrodes which offer superior selectivity, sensitivity, reagent less detection, and label free fabrication of biosensors. The present review article compiles the major knowledge surfaced on the subject since its inception incorporating the key review and experimental papers published during the last decade which extensively cover the development on the redox enzyme based 3rd generation electrochemical biosensors. The tenet involved in the function of these direct electrochemistry based enzyme electrodes, their characterizations and various strategies reported so far for their development such as, nanofabrication, polymer based and reconstitution approaches are elucidated. In addition, the possible challenges and the future prospects in the development of efficient biosensors following this direct electrochemistry based principle are discussed. A comparative account on the design strategies and critical performance factors involved in the 3rd generation biosensors among some selected prominent works published on the subject during last decade have also been included in a tabular form for ready reference to the readers. PMID:26735873

  12. Albion: cost-effective 3rd generation high-performance thermal imaging in the UK

    NASA Astrophysics Data System (ADS)

    McEwen, R. K.; Lupton, M.; Lawrence, M.; Knowles, P.; Wilson, M.; Dennis, P. N. J.; Gordon, N. T.; Lees, D. J.; Parsons, J. F.

    2006-09-01

    The first generation of high performance thermal imaging sensors in the UK was based on two axis opto-mechanical scanning systems and small (4-16 element) arrays of the SPRITE detector, developed during the 1970s. Almost two decades later, a 2nd Generation system, STAIRS C was introduced, based on single axis scanning and a long linear array of approximately 3000 elements. This paper addresses the development of the UK's 3rd Generation High Performance Thermal Imaging sensor systems, under a programme known as "Albion". Three new high performance detectors, manufactured in cadmium mercury telluride, operating in both MWIR and LWIR, providing high resolution and sensitivities without need for opto-mechanical scanning systems will be described. The CMT material is grown by MOVPE on low cost substrates and bump bonded to the silicon read out circuit (ROIC). All three detectors are designed to fit with existing standard Integrated Detector Cooling Assemblies (IDCAs). The two largest detectors will be integrated with field demonstrator cameras providing MWIR and LWIR solutions that can rapidly be tailored to specific military requirements. The remaining detector will be a LWIR device with a smart ROIC, facilitating integration times much longer than can typically be achieved with focal plane arrays and consequently yield very high thermal sensitivity. This device will be demonstrated in a lab based camera system.

  13. Albion: the UK 3rd generation high-performance thermal imaging programme

    NASA Astrophysics Data System (ADS)

    McEwen, R. K.; Lupton, M.; Lawrence, M.; Knowles, P.; Wilson, M.; Dennis, P. N. J.; Gordon, N. T.; Lees, D. J.; Parsons, J. F.

    2007-04-01

    The first generation of high performance thermal imaging sensors in the UK was based on two axis opto-mechanical scanning systems and small (4-16 element) arrays of the SPRITE detector, developed during the 1970s. Almost two decades later, a 2nd Generation system, STAIRS C was introduced, based on single axis scanning and a long linear array of approximately 3000 elements. The UK has now begun the industrialisation of 3 rd Generation High Performance Thermal Imaging under a programme known as "Albion". Three new high performance cadmium mercury telluride arrays are being manufactured. The CMT material is grown by MOVPE on low cost substrates and bump bonded to the silicon read out circuit (ROIC). To maintain low production costs, all three detectors are designed to fit with existing standard Integrated Detector Cooling Assemblies (IDCAs). The two largest focal planes are conventional devices operating in the MWIR and LWIR spectral bands. A smaller format LWIR device is also described which has a smart ROIC, enabling much longer stare times than are feasible with conventional pixel circuits, thus achieving very high sensitivity. A new reference surface technology for thermal imaging sensors is described, based on Negative Luminescence (NL), which offers several advantages over conventional peltier references, improving the quality of the Non-Uniformity Correction (NUC) algorithms.

  14. Simultaneous generation of 3G and millimeter-wave signals using a dual-electrode MZM in ROF systems

    NASA Astrophysics Data System (ADS)

    Ying, Xiang-yue; Xu, Tie-feng; Liu, Tai-jun; Nie, Qiu-hua; Wen, Hua-feng; Li, Jun

    2015-07-01

    A novel radio-over-fiber (ROF) scheme to simultaneously generate and transmit the 3rd generation telecommunication (3G) and millimeter-wave (MMW) signals by using a single dual-electrode Mach-Zehnder modulator (MZM) is proposed. There is no apparent nonlinearity induced by the ROF system. By employing this analog ROF signal transmission technique, highly transparent fiber-wireless convergence networks can be realized, which are ideal for multi-standard wireless system operation.

  15. SESAME, A 3rd Generation Synchrotron Light Source for the Middle East

    SciTech Connect

    Einfeld, D.; Hasnain, S.S.; Sayers, Z.; Schopper, H.; Winick, H.; Al-Dmour, E.

    2004-05-12

    Developed under the auspices of UNESCO, SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) will be a major international research centre in the Middle East and Mediterranean region. On 6th of January 2003, the official foundation of SESAME took place. The facility is located in Allan, Jordan, 30 km North-West of Amman. As of August 2003 the Founding Members are Bahrain, Egypt, Iran, Israel, Jordan, Pakistan, Palestine, Turkey and United Arabic Emirates, representing a population of over 300 million. SESAME will be a 2.5 GeV 3rd Generation light source (emittance 24.6 nm.rad, circumference {approx}125m). About 40% of the circumference is available for insertion devices (average length 2.75m) in 13 straight sections. Beam lines are up to 36m. The site and a building are provided by Jordan. Construction started in August 2003. The scientific program will start with up to 6 beam lines: MAD Protein Crystallography, SAXS and WAXS for polymers and proteins, Powder Diffraction for material science, UV/VUV/SXR Photoelectron Spectroscopy and Photoabsorption Spectroscopy, IR Spectroscopy, and EXAFS.

  16. SESAME-A 3rd Generation Synchrotron Light Source for the Middle East

    NASA Astrophysics Data System (ADS)

    Winick, Herman

    2010-02-01

    Developed under the auspices of UNESCO and modeled on CERN, SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) is an international research center in construction in Jordan. It will enable world class research by scientists from the region, reversing the brain drain. It will also build bridges between diverse societies, contributing to a culture of peace through international cooperation in science. The centerpiece is a synchrotron light source originating from BESSY I, a gift by Germany. The upgraded machine, a 2.5 GeV 3rd Generation Light Source (133m circumference, 26nm-rad emittance and 12 places for insertion devices), will provide light from infra-red to hard X-rays, offering excellent opportunities to train local scientists and attract those working abroad to return. The SESAME Council meets twice each year and presently has nine Members (Bahrain, Cyprus, Egypt, Iran, Israel, Jordan, Pakistan, Palestinian Authority, Turkey). Members have responsibility for the project and provide the annual operations budget (1.5M US dollars in 2009, expected to rise to about 5M when operation starts in 2012-13). Jordan provided the site, building, and infrastructure. A staff of 20 is installing the 0.8 GeV BESSY I injection system. The facility will have the capacity to serve 30 or more experiments operating simultaneously. See www.sesame.org.jo )

  17. New half-film method for measuring Al2O3 film MTF of 3rd generation image intensifier

    NASA Astrophysics Data System (ADS)

    Cheng, Yaojin; Shi, Feng; Bai, Xiaofeng; Zhu, Yufeng; Yan, Lei; Liu, Feng; Li, Min

    2012-10-01

    In 3rd generation image intensifier, Al2O3 film on the input of MCP is a serious influence factor on device MTF due to its electron scattering process. There are no reportes about how to measure the MTF of Al2O3 film. In this paper a new Half-film comparssion test method is creatively established for determing the film MTF, which overcomes the difficulty of measuring super thin film less than a few nm. In this way, the MTF curves of 10nm Al2O3 film can be accurately obtained. The measurement results show that 10nm Al2O3 film obviously decay the MTF performance of the 3rd generation image intensifier and take an important role in the improvement work of 3rd generation image intensifier MTF and resolution performances.

  18. The Lived Experiences of 3rd Generation and beyond U.S.-Born Mexican Heritage College Students: A Qualitative Study

    ERIC Educational Resources Information Center

    Galvan, Richard

    2011-01-01

    The purpose of this study was to describe the psychosocial and identity challenges of 3rd generation and beyond U.S.-born (3GAB-USB) Mexican heritage college students. Alvarez (1973) has written about the psychosocial impact "hybridity" can have on a U.S.- born (USB) Mexican individual who incorporates two distinct cultures (American and Mexican)…

  19. SESAME — A 3rd Generation Synchrotron Light Source for the Middle East

    NASA Astrophysics Data System (ADS)

    Å°lkü, Dinçer; Rahighi, Javad; Winick, Herman

    2007-01-01

    SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) will be the Middle East's first international research center. It is a cooperative venture by the scientists and governments of the region with founding members Bahrain, Egypt, Israel, Jordan, Pakistan, Palestine Authority, and Turkey. Iran is in the process of finalizing its formal membership. Other countries (Cyprus, Morocco, and the United Arab Emirates) are also expected to join. The permanent Council of member states has full responsibility for the project. Members provide the annual operating budget. Observer countries are Germany, Greece, Italy, Kuwait, Portugal, Russian Federation, Sweden, the UK, and the US. SESAME is being developed under the umbrella of UNESCO. Jordan was selected as the building site. SESAME will offer excellent opportunities for training of Middle East scientists and attract those working abroad to consider returning. SESAME will be a 2.5GeV 3rd Generation light source (emittance 26nm-rad, circumference ˜133m), providing excellent performance for structural molecular biology, molecular environmental science, surface and interface science, microelectromechanical devices, x-ray imaging, archaeological microanalysis, and materials characterization. It will cover a broad spectral range from the infrared to hard x-rays and will have 12 straight sections for insertion devices (average length 2.75m). The injector will be the BESSY I 0.8 GeV booster synchrotron which has been given as a gift from Germany. Four committees advise the Council and assist in developing the technical design, beam lines, user community, and scientific Program. The SESAME building, now in construction with funds and a site provided by Jordan, is scheduled for completion in late 2006 after which the BESSY I injector will be installed. First stored beam in the new 2.5 GeV ring is planned for 2009 with six initial beamlines planned. Some beamlines will be built by member countries

  20. SESAME - A 3rd Generation Synchrotron Light Source for the Middle East

    NASA Astrophysics Data System (ADS)

    U˝Lkü, Dinçer; Rahighi, Javad; Winick, Herman

    2007-01-01

    SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) will be the Middle East's first international research center. It is a cooperative venture by the scientists and governments of the region with founding members Bahrain, Egypt, Israel, Jordan, Pakistan, Palestine Authority, and Turkey. Iran is in the process of finalizing its formal membership. Other countries (Cyprus, Morocco, and the United Arab Emirates) are also expected to join. The permanent Council of member states has full responsibility for the project. Members provide the annual operating budget. Observer countries are Germany, Greece, Italy, Kuwait, Portugal, Russian Federation, Sweden, the UK, and the US. SESAME is being developed under the umbrella of UNESCO. Jordan was selected as the building site. SESAME will offer excellent opportunities for training of Middle East scientists and attract those working abroad to consider returning. SESAME will be a 2.5GeV 3rd Generation light source (emittance 26nm-rad, circumference ~133m), providing excellent performance for structural molecular biology, molecular environmental science, surface and interface science, microelectromechanical devices, x-ray imaging, archaeological microanalysis, and materials characterization. It will cover a broad spectral range from the infrared to hard x-rays and will have 12 straight sections for insertion devices (average length 2.75m). The injector will be the BESSY I 0.8 GeV booster synchrotron which has been given as a gift from Germany. Four committees advise the Council and assist in developing the technical design, beam lines, user community, and scientific Program. The SESAME building, now in construction with funds and a site provided by Jordan, is scheduled for completion in late 2006 after which the BESSY I injector will be installed. First stored beam in the new 2.5 GeV ring is planned for 2009 with six initial beamlines planned. Some beamlines will be built by member countries

  1. SESAME - A 3rd Generation Synchrotron Light Source for the Middle East

    SciTech Connect

    Ulkue, Dincer; Rahighi, Javad; Winick, Herman

    2007-01-19

    SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) will be the Middle East's first international research center. It is a cooperative venture by the scientists and governments of the region with founding members Bahrain, Egypt, Israel, Jordan, Pakistan, Palestine Authority, and Turkey. Iran is in the process of finalizing its formal membership. Other countries (Cyprus, Morocco, and the United Arab Emirates) are also expected to join. The permanent Council of member states has full responsibility for the project. Members provide the annual operating budget. Observer countries are Germany, Greece, Italy, Kuwait, Portugal, Russian Federation, Sweden, the UK, and the US. SESAME is being developed under the umbrella of UNESCO. Jordan was selected as the building site. SESAME will offer excellent opportunities for training of Middle East scientists and attract those working abroad to consider returning. SESAME will be a 2.5GeV 3rd Generation light source (emittance 26nm-rad, circumference {approx}133m), providing excellent performance for structural molecular biology, molecular environmental science, surface and interface science, microelectromechanical devices, x-ray imaging, archaeological microanalysis, and materials characterization. It will cover a broad spectral range from the infrared to hard x-rays and will have 12 straight sections for insertion devices (average length 2.75m). The injector will be the BESSY I 0.8 GeV booster synchrotron which has been given as a gift from Germany. Four committees advise the Council and assist in developing the technical design, beam lines, user community, and scientific Program. The SESAME building, now in construction with funds and a site provided by Jordan, is scheduled for completion in late 2006 after which the BESSY I injector will be installed. First stored beam in the new 2.5 GeV ring is planned for 2009 with six initial beamlines planned. Some beamlines will be built by member

  2. [Antidepressives of the 3rd, 4th and 5th generation].

    PubMed

    Svestka, J

    1994-02-01

    Antidepressants are classified into five generations. Preparations of the first generation affect various neurotransmitter systems and are therefore associated with many undesirable effects (e.g. tricyclic antidepressants, maprotiline). The second generation of antidepressants is already devoid of anticholinergic action and their adrenolytic and antihistaminic effects are weaker (e.g. mianserine, mirtazapine, trazodone). The antidepressant action of preparations of the third generation is mediated only by one of the three main neurotransmitter systems for depression (5-HT, noradrenaline, dopamine) and does not affect muscarine, histamine and adrenergic cerebral systems (e.g. SSRI, ipsapirone, viloxazine, reboxetine, bupropione). Recently antidepressants of the fourth generation were synthetized which influence only the serotonin, and noradrenaline or dopamine system (e.g. milnacipran, befloxatone). The fifth generation of antidepressants foresees the exclusive action on 5-HT, noradrenaline and dopamine systems of the CNS in varying ratios (e.g. venlafaxine, cericlamine). PMID:8174184

  3. Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: preparation, in vitro and in vivo evaluation.

    PubMed

    He, Zhijian; Schulz, Anita; Wan, Xiaomeng; Seitz, Joshua; Bludau, Herdis; Alakhova, Daria Y; Darr, David B; Perou, Charles M; Jordan, Rainer; Ojima, Iwao; Kabanov, Alexander V; Luxenhofer, Robert

    2015-06-28

    The clinically and commercially successful taxanes, paclitaxel and docetaxel suffer from two major drawbacks, namely their very low aqueous solubility and the risk of developing resistance. Here, we present a method that overcomes both drawbacks in a very simple manner. We formulated 3rd generation taxoids, able to avoid common drug resistance mechanisms with doubly amphiphilic poly(2-oxazoline)s (POx), a safe and highly efficient polymer for the formulation of extremely hydrophobic drugs. We found excellent solubilization of different 3rd generation taxoids irrespective of the drug's chemical structures with essentially quantitative drug loading and final drug to polymer ratios around unity. The small, highly loaded micelles with a hydrodynamic diameter of less than 100nm are excellently suited for parenteral administration. Moreover, a selected formulation with the taxoid SB-T-1214 is about one to two orders of magnitude more active in vitro than paclitaxel in the multidrug resistant breast cancer cell line LCC6-MDR. In contrast, in wild-type LCC6, no difference was observed. Using a q4d×4 dosing regimen, we also found that POx/SB-T-1214 significantly inhibits the growth of LCC6-MDR orthotropic tumors, outperforming commercial paclitaxel drug Taxol and Cremophor EL formulated SB-T-1214. PMID:25725361

  4. Concentrating-solar biomass gasification process for a 3rd generation biofuel.

    PubMed

    Hertwich, Edgar G; Zhang, Xiangping

    2009-06-01

    A new concept of producing synfuel from biomass using concentrating solar energy as its main energy source is proposed in this paper. The aim of the concept is to obtain an easy to handle fuel with near-zero CO2 emission and reduced land-use requirements compared to first and second generation biofuels. The concept's key feature is the use of high-temperature heat from a solar concentrating tower to drive the chemical process of converting biomassto a biofuel, obtaining a near-complete utilization of carbon atoms in the biomass. H2 from water electrolysis with solar power is used for reverse water gas shift to avoid producing CO2 during the process. In a chemical process simulation, we compare the solar biofuel concept with two other advanced synfuel concepts: second generation biofuel and coal-to-liquid, both using gasification technology and capture and storage of CO2 generated in the fuel production. The solar-driventhird generation biofuel requires only 33% of the biomass input and 38% of total land as the second generation biofuel, while still exhibiting a CO2-neutral fuel cycle. With CO2 capture, second generation biofuel would lead to the removal of 50% of the carbon in the biomass from the atmosphere. There is a trade-off between reduced biomass feed costs and the increased capital requirements for the solar-driven process; it is attractive at intermediate biomass and CO2 prices. PMID:19569353

  5. Safe Life Propulsion Design Technologies (3rd Generation Propulsion Research and Technology)

    NASA Technical Reports Server (NTRS)

    Ellis, Rod

    2000-01-01

    The tasks outlined in this viewgraph presentation on safe life propulsion design technologies (third generation propulsion research and technology) include the following: (1) Ceramic matrix composite (CMC) life prediction methods; (2) Life prediction methods for ultra high temperature polymer matrix composites for reusable launch vehicle (RLV) airframe and engine application; (3) Enabling design and life prediction technology for cost effective large-scale utilization of MMCs and innovative metallic material concepts; (4) Probabilistic analysis methods for brittle materials and structures; (5) Damage assessment in CMC propulsion components using nondestructive characterization techniques; and (6) High temperature structural seals for RLV applications.

  6. InAs/GaSb type II superlattices for advanced 2nd and 3rd generation detectors

    NASA Astrophysics Data System (ADS)

    Walther, Martin; Rehm, Robert; Schmitz, Johannes; Fleissner, Joachim; Rutz, Frank; Kirste, Lutz; Scheibner, Ralf; Wendler, Joachim; Ziegler, Johann

    2010-01-01

    InAs/GaSb short-period superlattices (SL) based on GaSb, InAs and AlSb have proven their great potential for high performance infrared detectors. Lots of interest is currently focused on the development of short-period InAs/GaSb SLs for advanced 2nd and 3rd generation infrared detectors between 3 - 30 μm. For the fabrication of mono- and bispectral thermal imaging systems in the mid-wavelength infrared region (MWIR) a manufacturable technology for high responsivity thermal imaging systems has been developed. InAs/GaSb short-period superlattices can be fabricated with up to 1000 periods in the intrinsic region without revealing diffusion limited behavior. This enables the fabrication of InAs/GaSb SL camera systems with high responsivity comparable to state of the art CdHgTe and InSb detectors. The material system is also ideally suited for the fabrication of dual-color MWIR/MWIR InAs/GaSb SL camera systems with high quantum efficiency for missile approach warning systems with simultaneous and spatially coincident detection in both spectral channels.

  7. Chrysler improved numerical differencing analyzer for third generation computers CINDA-3G

    NASA Technical Reports Server (NTRS)

    Gaski, J. D.; Lewis, D. R.; Thompson, L. R.

    1972-01-01

    New and versatile method has been developed to supplement or replace use of original CINDA thermal analyzer program in order to take advantage of improved systems software and machine speeds of third generation computers. CINDA-3G program options offer variety of methods for solution of thermal analog models presented in network format.

  8. Efficacy of a 3rd generation high-throughput sequencing platform for analyses of 16S rRNA genes from environmental samples.

    PubMed

    Mosher, Jennifer J; Bernberg, Erin L; Shevchenko, Olga; Kan, Jinjun; Kaplan, Louis A

    2013-11-01

    Longer sequences of the bacterial 16S rRNA gene could provide greater phylogenetic and taxonomic resolutions and advance knowledge of population dynamics within complex natural communities. We assessed the accuracy of a Pacific Biosciences (PacBio) single molecule, real time (SMRT) sequencing based on DNA polymerization, a promising 3rd generation high-throughput technique, and compared this to the 2nd generation Roche 454 pyrosequencing platform. Amplicons of the 16S rRNA gene from a known isolate, Shewanella oneidensis MR1, and environmental samples from two streambed habitats, rocks and sediments, and a riparian zone soil, were analyzed. On the PacBio we analyzed ~500 bp amplicons that covered the V1-V3 regions and the full 1500 bp amplicons of the V1-V9 regions. On the Roche 454 we analyzed the ~500 bp amplicons. Error rates associated with the isolate were lowest with the Roche 454 method (2%), increased by more than 2-fold for the 500 bp amplicons with the PacBio SMRT chip (4-5%), and by more than 8-fold for the full gene with the PacBio SMRT chip (17-18%). Higher error rates with the PacBio SMRT chip artificially inflated estimates of richness and lowered estimates of coverage for environmental samples. The 3rd generation sequencing technology we evaluated does not provide greater phylogenetic and taxonomic resolutions for studies of microbial ecology. PMID:23999276

  9. [3rd generation's TKI in lung cancer non-small cell EGFR-mutated having acquired a secondary T790M resistance].

    PubMed

    Brosseau, Solenn; Viala, Marie; Varga, Andréa; Planchard, David; Besse, Benjamin; Soria, Jean-Charles

    2015-09-01

    Activating EGFR mutations discovery and efficacy of 1st generation tyrosine kinase inhibitors (TKI), such as erlotinib or gefitinib, inaugurated the beginning of personalized medicine in the treatment of EGFR-mutated non-small cell lung cancer (NSCLC). However, all patients showed a tumor progression of 10 to 16 months after the onset of TKI therapy related to molecular resistance mechanisms as T790M mutation. Till now, patients suffering from EGFR-mutated NSCLC with acquired resistance have conventional treatment options. Two new 3rd generations' TKI, AZD9291 and rociletinib, are currently being studied in phases 1-3 studies. Preliminary results show relevant therapeutic properties in patients with T790M mutated-EGFR NSCLC. This review aims to highlight these new molecules, their effectiveness and their clinical toxicities in the treatment of advanced stages of NSCLC expressing the T790M mutation. PMID:26235419

  10. Passive magnetic bearing in the 3rd generation miniature axial flow pump-the valvo pump 2.

    PubMed

    Okamoto, Eiji; Ishida, Yuya; Yano, Tetsuya; Mitamura, Yoshinori

    2015-06-01

    The new miniature axial flow pump (valvo pump 2) that is installed at the base of the ascending aorta consists of a six-phase stator, an impeller in which four neodymium magnets are incorporated, and passive magnetic bearings that suspend the impeller for axial levitation. The impeller is sustained by hydrodynamic force between the blade tip of the impeller and the inner housing of the stator. The passive magnetic bearing consists of a ring neodymium magnet and a columnar neodymium magnet. The ring neodymium magnet is set in the stationary side and the columnar neodymium magnet is incorporated in the impeller shaft. Both neodymium magnets are coaxially mounted, and the anterior and posterior passive magnetic bearings suspend the impeller by repulsion force against the hydrodynamic force that acts to move the impeller in the inflow port direction. The passive magnetic bearing was evaluated by a tensile test, and the levitation force of 8.5 N and stiffness of 2.45 N/mm was obtained. Performance of the axial flow pump was evaluated by an in vitro experiment. The passive magnetic bearing showed sufficient levitation capacity to suspend the impeller in an axial direction. In conclusion, the passive magnetic bearing is promising to be one of levitation technology for the third-generation axial flow blood pump. PMID:25407124

  11. The perceptions of professional soccer players on the risk of injury from competition and training on natural grass and 3rd generation artificial turf

    PubMed Central

    2014-01-01

    Background The purpose of this study was to describe professional soccer players’ perceptions towards injuries, physical recovery and the effect of surface related factors on injury resulting from soccer participation on 3rd generation artificial turf (FT) compared to natural grass (NG). Methods Information was collected through a questionnaire that was completed by 99 professional soccer players from 6 teams competing in Major League Soccer (MLS) during the 2011 season. Results The majority (93% and 95%) of the players reported that playing surface type and quality influenced the risk of sustaining an injury. Players believed that playing and training on FT increased the risk of sustaining a non-contact injury as opposed to a contact injury. The players identified three surface related risk factors on FT, which they related to injuries and greater recovery times: 1) Greater surface stiffness 2) Greater surface friction 3) Larger metabolic cost to playing on artificial grounds. Overall, 94% of the players chose FT as the surface most likely to increase the risk of sustaining an injury. Conclusions Players believe that the risk of injury differs according to surface type, and that FT is associated with an increased risk of non-contact injury. Future studies should be designed prospectively to systematically track the perceptions of groups of professional players training and competing on FT and NG. PMID:24581229

  12. A novel amperometric alcohol biosensor developed in a 3rd generation bioelectrode platform using peroxidase coupled ferrocene activated alcohol oxidase as biorecognition system.

    PubMed

    Chinnadayyala, Somasekhar R; Kakoti, Ankana; Santhosh, Mallesh; Goswami, Pranab

    2014-05-15

    Alcohol oxidase (AOx) with a two-fold increase in efficiency (Kcat/Km) was achieved by physical entrapment of the activator ferrocene in the protein matrix through a simple microwave based partial unfolding technique and was used to develop a 3rd generation biosensor for improved detection of alcohol in liquid samples. The ferrocene molecules were stably entrapped in the AOx protein matrix in a molar ratio of ~3:1 through electrostatic interaction with the Trp residues involved in the functional activity of the enzyme as demonstrated by advanced analytical techniques. The sensor was fabricated by immobilizing ferrocene entrapped alcohol oxidase (FcAOx) and sol-gel chitosan film coated horseradish peroxidase (HRP) on a multi-walled carbon nanotube (MWCNT) modified glassy carbon electrode through layer-by-layer technique. The bioelectrode reactions involved the formation of H2O2 by FcAOx biocatalysis of substrate alcohol followed by HRP-catalyzed reduction of the liberated H2O2 through MWCNT supported direct electron transfer mechanism. The amperometric biosensor exhibited a linear response to alcohol in the range of 5.0 × 10(-6) to 30 × 10(-4)mol L(-1) with a detection limit of 2.3 × 10(-6) mol L(-1), and a sensitivity of 150 µA mM(-1) cm(-2). The biosensor response was steady for 28 successive measurements completed in a period of 5h and retained ~90% of the original response even after four weeks when stored at 4 °C. The biosensor was successfully applied for the determination of alcohol in commercial samples and its performance was validated by comparing with the data obtained by GC analyses of the samples. PMID:24368229

  13. Image Quality of 3rd Generation Spiral Cranial Dual-Source CT in Combination with an Advanced Model Iterative Reconstruction Technique: A Prospective Intra-Individual Comparison Study to Standard Sequential Cranial CT Using Identical Radiation Dose

    PubMed Central

    Wenz, Holger; Maros, Máté E.; Meyer, Mathias; Förster, Alex; Haubenreisser, Holger; Kurth, Stefan; Schoenberg, Stefan O.; Flohr, Thomas; Leidecker, Christianne; Groden, Christoph; Scharf, Johann; Henzler, Thomas

    2015-01-01

    Objectives To prospectively intra-individually compare image quality of a 3rd generation Dual-Source-CT (DSCT) spiral cranial CT (cCT) to a sequential 4-slice Multi-Slice-CT (MSCT) while maintaining identical intra-individual radiation dose levels. Methods 35 patients, who had a non-contrast enhanced sequential cCT examination on a 4-slice MDCT within the past 12 months, underwent a spiral cCT scan on a 3rd generation DSCT. CTDIvol identical to initial 4-slice MDCT was applied. Data was reconstructed using filtered backward projection (FBP) and 3rd-generation iterative reconstruction (IR) algorithm at 5 different IR strength levels. Two neuroradiologists independently evaluated subjective image quality using a 4-point Likert-scale and objective image quality was assessed in white matter and nucleus caudatus with signal-to-noise ratios (SNR) being subsequently calculated. Results Subjective image quality of all spiral cCT datasets was rated significantly higher compared to the 4-slice MDCT sequential acquisitions (p<0.05). Mean SNR was significantly higher in all spiral compared to sequential cCT datasets with mean SNR improvement of 61.65% (p*Bonferroni0.05<0.0024). Subjective image quality improved with increasing IR levels. Conclusion Combination of 3rd-generation DSCT spiral cCT with an advanced model IR technique significantly improves subjective and objective image quality compared to a standard sequential cCT acquisition acquired at identical dose levels. PMID:26288186

  14. Effects of Deep Water Source-Sink Terms in 3rd generation Wave Model SWAN using different wind data in Black Sea

    NASA Astrophysics Data System (ADS)

    Kirezci, Cagil; Ozyurt Tarakcioglu, Gulizar

    2016-04-01

    Coastal development in Black Sea has increased in recent years. Therefore, careful monitoring of the storms and verification of numerical tools with reliable data has become important. Previous studies by Kirezci and Ozyurt (2015) investigated extreme events in Black Sea using different wind datasets (NCEP's CFSR and ECMWF's operational datasets) and different numerical tools (SWAN and Wavewatch III). These studies showed that significant effect to results is caused by the deep water source-sink terms (wave growth by wind, deep water dissipation of wave energy (whitecapping) and deep water non-linear wave-wave interactions). According to Timmermans(2015), uncertainty about wind forcing and the process of nonlinear wave-wave interactions are found to be dominant in numerical wave modelling. Therefore, in this study deep water source and sink term solution approaches of 3rd generation numerical tool (SWAN model) are tested, validated and compared using the selected extreme storms in Black Sea. 45 different storms and storm like events observed in Black Sea between years 1994-1999 are selected to use in the models. The storm selection depends on the instrumental wave data (significant wave heights, mean wave period and mean wave direction) obtained in NATO-TU Waves project by the deep water buoy measurements at Hopa, Sinop, Gelendzhik, and wind data (mean and peak wind speeds, storm durations) of the regarding events. 2 different wave growth by wind with the corresponding deep water dissipation terms and 3 different wave -wave interaction terms of SWAN model are used in this study. Wave growth by wind consist of two parts, linear growth which is explained by Cavaleri and Malanotte-Rizzoli(1981),and dominant exponential growth. There are two methods in SWAN model for exponential growth of wave, first one by Snyder et al. (1981), rescaled in terms of friction velocity by Komen et. al (1984) which is derived using driving wind speed at 10m elevation with related drag

  15. Effects of Deep Water Source-Sink Terms in 3rd generation Wave Model SWAN using different wind data in Black Sea

    NASA Astrophysics Data System (ADS)

    Kirezci, Cagil; Ozyurt Tarakcioglu, Gulizar

    2016-04-01

    Coastal development in Black Sea has increased in recent years. Therefore, careful monitoring of the storms and verification of numerical tools with reliable data has become important. Previous studies by Kirezci and Ozyurt (2015) investigated extreme events in Black Sea using different wind datasets (NCEP's CFSR and ECMWF's operational datasets) and different numerical tools (SWAN and Wavewatch III). These studies showed that significant effect to results is caused by the deep water source-sink terms (wave growth by wind, deep water dissipation of wave energy (whitecapping) and deep water non-linear wave-wave interactions). According to Timmermans(2015), uncertainty about wind forcing and the process of nonlinear wave-wave interactions are found to be dominant in numerical wave modelling. Therefore, in this study deep water source and sink term solution approaches of 3rd generation numerical tool (SWAN model) are tested, validated and compared using the selected extreme storms in Black Sea. 45 different storms and storm like events observed in Black Sea between years 1994-1999 are selected to use in the models. The storm selection depends on the instrumental wave data (significant wave heights, mean wave period and mean wave direction) obtained in NATO-TU Waves project by the deep water buoy measurements at Hopa, Sinop, Gelendzhik, and wind data (mean and peak wind speeds, storm durations) of the regarding events. 2 different wave growth by wind with the corresponding deep water dissipation terms and 3 different wave -wave interaction terms of SWAN model are used in this study. Wave growth by wind consist of two parts, linear growth which is explained by Cavaleri and Malanotte-Rizzoli(1981),and dominant exponential growth. There are two methods in SWAN model for exponential growth of wave, first one by Snyder et al. (1981), rescaled in terms of friction velocity by Komen et. al (1984) which is derived using driving wind speed at 10m elevation with related drag

  16. CINDA-3G: Improved Numerical Differencing Analyzer Program for Third-Generation Computers

    NASA Technical Reports Server (NTRS)

    Gaski, J. D.; Lewis, D. R.; Thompson, L. R.

    1970-01-01

    The goal of this work was to develop a new and versatile program to supplement or replace the original Chrysler Improved Numerical Differencing Analyzer (CINDA) thermal analyzer program in order to take advantage of the improved systems software and machine speeds of the third-generation computers.

  17. APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in vivo.

    PubMed

    Fan, Jun; Ma, Guangyong; Nosaka, Kisato; Tanabe, Junko; Satou, Yorifumi; Koito, Atsushi; Wain-Hobson, Simon; Vartanian, Jean-Pierre; Matsuoka, Masao

    2010-07-01

    Human T-cell leukemia virus type 1 (HTLV-1) induces cell proliferation after infection, leading to efficient transmission by cell-to-cell contact. After a long latent period, a fraction of carriers develop adult T-cell leukemia (ATL). Genetic changes in the tax gene in ATL cells were reported in about 10% of ATL cases. To determine genetic changes that may occur throughout the provirus, we determined the entire sequence of the HTLV-1 provirus in 60 ATL cases. Abortive genetic changes, including deletions, insertions, and nonsense mutations, were frequent in all viral genes except the HBZ gene, which is transcribed from the minus strand of the virus. G-to-A base substitutions were the most frequent mutations in ATL cells. The sequence context of G-to-A mutations was in accordance with the preferred target sequence of human APOBEC3G (hA3G). The target sequences of hA3G were less frequent in the plus strand of the HBZ coding region than in other coding regions of the HTLV-1 provirus. Nonsense mutations in viral genes including tax were also observed in proviruses from asymptomatic carriers, indicating that these mutations were generated during reverse transcription and prior to oncogenesis. The fact that hA3G targets the minus strand during reverse transcription explains why the HBZ gene is not susceptible to such nonsense mutations. HTLV-1-infected cells likely take advantage of hA3G to escape from the host immune system by losing expression of viral proteins. PMID:20463074

  18. Higgs Properties in the Fourth Generation MSSM: Boosted Signals Over the 3G Plan

    SciTech Connect

    Cotta, R.C.; Hewett, J.L.; Ismail, A.; Le, M.-P.; Rizzo, T.G.; /SLAC

    2011-08-15

    The generalization of the MSSM to the case of four chiral fermion generations (4GMSSM) can lead to significant changes in the phenomenology of the otherwise familiar Higgs sector. In most of the 3GMSSM parameter space, the lighter CP-even h is {approx} 115-125 GeV and mostly Standard Model-like while H,A,H{sup {+-}} are all relatively heavy. Furthermore, the ratio of Higgs vevs, tan {beta}, is relatively unconstrained. In contrast to this, in the 4GMSSM, heavy fourth generation fermion loops drive the masses of h,H,H{sup {+-}} to large values while the CP-odd boson, A, can remain relatively light and tan {beta} is restricted to the range 1/2 {approx}< tan {beta} {approx}< 2 due to perturbativity requirements on Yukawa couplings. We explore this scenario in some detail, concentrating on the collider signatures of the light CP-odd Higgs at both the Tevatron and LHC. We find that while gg {yields} A may lead to a potential signal in the {tau}{sup +}{tau}{sup -} channel at the LHC, A may first be observed in the {gamma}{gamma} channel due to a highly loop-enhanced cross section that can be more than an order of magnitude greater than that of a SM Higgs for A masses of {approx} 115-120 and tan {beta} < 1. We find that the CP-even states h,H are highly mixed and can have atypical branching fractions. Precision electroweak constraints, particularly for the light A parameter space region, are examined in detail.

  19. Real-World Use of 3rd Line Therapy for Multiple Myeloma in Austria: An Austrian Myeloma Registry (AMR) Analysis of the Therapeutic Landscape and Clinical Outcomes prior to the Use of Next Generation Myeloma Therapeutics

    PubMed Central

    Willenbacher, Ella; Weger, Roman; Rochau, Ursula; Siebert, Uwe; Willenbacher, Wolfgang

    2016-01-01

    Objective Clinical trials demonstrate improving survival in patients with multiple myeloma (MM) after treatment. However, it is unclear whether increased survival translates to a similar benefit in a real world setting. Methods We analyzed the overall survival of 347 multiple myeloma patients in Austria by means of a national registry (AMR), focused on results from 3rd and later lines of therapy. This benchmark was chosen to define a baseline prior to the broad application of upcoming 2nd generation drugs (carfilzomib, pomalidomide). Results Projected 10 years survival for patients with MM in Austria is estimated to be 56% in patients diagnosed in between the years 2011–2014, 21% in patients with a diagnosis made between 2000–2005, and 39% in those with a diagnosis made between 2006–2010). For the same intervals a significant increase in the use of both bortezomib, lenalidomide and thalidomide—so called IMiDs (from 2005 onwards) and their simultaneous use in combination therapies (from 2010 onwards) could be shown. The use of autologous transplantation (ASCT) remained more or less constant at ~ 35% of patients in the 1st line setting over the whole period, comparing well to international practice patterns, while the use of 2nd line ASCT increased from 5.5% to 18.7% of patients. Patients in 3rd or later line treatment (n = 105), showed that even in relapsed and refractory disease median survival was 27 months with a considerable proportion of long-term survivors (~20%). Conclusion & Perspective With the expected emergence of additional active anti-myeloma compounds, we aim to assess survival in patients with relapsed and refractory MM. PMID:26937956

  20. SPT-3G: a next-generation cosmic microwave background polarization experiment on the South Pole telescope

    NASA Astrophysics Data System (ADS)

    Benson, B. A.; Ade, P. A. R.; Ahmed, Z.; Allen, S. W.; Arnold, K.; Austermann, J. E.; Bender, A. N.; Bleem, L. E.; Carlstrom, J. E.; Chang, C. L.; Cho, H. M.; Cliche, J. F.; Crawford, T. M.; Cukierman, A.; de Haan, T.; Dobbs, M. A.; Dutcher, D.; Everett, W.; Gilbert, A.; Halverson, N. W.; Hanson, D.; Harrington, N. L.; Hattori, K.; Henning, J. W.; Hilton, G. C.; Holder, G. P.; Holzapfel, W. L.; Irwin, K. D.; Keisler, R.; Knox, L.; Kubik, D.; Kuo, C. L.; Lee, A. T.; Leitch, E. M.; Li, D.; McDonald, M.; Meyer, S. S.; Montgomery, J.; Myers, M.; Natoli, T.; Nguyen, H.; Novosad, V.; Padin, S.; Pan, Z.; Pearson, J.; Reichardt, C.; Ruhl, J. E.; Saliwanchik, B. R.; Simard, G.; Smecher, G.; Sayre, J. T.; Shirokoff, E.; Stark, A. A.; Story, K.; Suzuki, A.; Thompson, K. L.; Tucker, C.; Vanderlinde, K.; Vieira, J. D.; Vikhlinin, A.; Wang, G.; Yefremenko, V.; Yoon, K. W.

    2014-07-01

    We describe the design of a new polarization sensitive receiver, spt-3g, for the 10-meter South Pole Telescope (spt). The spt-3g receiver will deliver a factor of ~20 improvement in mapping speed over the current receiver, spt-pol. The sensitivity of the spt-3g receiver will enable the advance from statistical detection of B-mode polarization anisotropy power to high signal-to-noise measurements of the individual modes, i.e., maps. This will lead to precise (~0.06 eV) constraints on the sum of neutrino masses with the potential to directly address the neutrino mass hierarchy. It will allow a separation of the lensing and inflationary B-mode power spectra, improving constraints on the amplitude and shape of the primordial signal, either through spt-3g data alone or in combination with bicep2/keck, which is observing the same area of sky. The measurement of small-scale temperature anisotropy will provide new constraints on the epoch of reionization. Additional science from the spt-3g survey will be significantly enhanced by the synergy with the ongoing optical Dark Energy Survey (des), including: a 1% constraint on the bias of optical tracers of large-scale structure, a measurement of the differential Doppler signal from pairs of galaxy clusters that will test General Relativity on ~200Mpc scales, and improved cosmological constraints from the abundance of clusters of galaxies

  1. Key technologies and concepts for beyond-3G networks

    NASA Astrophysics Data System (ADS)

    Pehkonen, Kari; Uskela, Sami; Kalliojarvi, Kari; Oksanen, Lauri; Rikkinen, Kari

    2001-10-01

    Standardization of 3rd Generation (3G) mobile communication systems has produced the first specification releases and the commercial deployment of the 3G systems has started. Whereas 1G and 2G focused on efficiently providing voice services, in 3G a lot of attention has been devoted to solutions that support both Circuit Switched (CS) and Packet Switched (PS) communication. That has called for very flexible air interface and network solutions. 3G will continue to evolve and there are already on-going standardization activities that will, for example, boost the peak data rates up to 5-10 Mbps and improve spectral efficiency by 2-4 times. In the future, 3G evolution will be going towards 10/100 Mbps peak data rates in wide/local are coverage, respectively. This will take place partly because of technical improvements of 3G radio interface solutions, but also due to network evolution which will allow the integration other radio access methods like radio LANs into the 3G system. In longer term the 3G network evolution will be going towards ALL-IP networks. As 3G evolution seems to be going towards 10 Mbps/100 Mbps peak data rates and ALL-IP networks any beyond 3G air interface or network solution should be clearly better in order to justify its technical and commercial feasibility. Given the long evolution time of 3G and integration of other radio access schemes with 3G radio we may not even see a new, complete beyond 3G system being developed. Maybe we will just witness the emergence of a new, more advanced radio access solution which will then be connected to the evolving 3G network. As 3G evolution will continue for several years to come the research targets for any beyond 3G solutions must be set very high. When it comes to air interface, we should aim at 100 Mbps peak data rates for wide area access with high mobility, and at 1 Gbps for local area access with low mobility. Regarding possible commercial launches of any beyond 3G systems or solutions they could then

  2. BACODINE/3rd Interplanetary Network burst localization

    SciTech Connect

    Hurley, K.; Barthelmy, S.; Butterworth, P.; Cline, T.; Sommer, M.; Boer, M.; Niel, M.; Kouveliotou, C.; Fishman, G.; Meegan, C.

    1996-08-01

    Even with only two widely separated spacecraft (Ulysses and GRO), 3rd Interplanetary Network (IPN) localizations can reduce the areas of BATSE error circles by two orders of magnitude. Therefore it is useful to disseminate them as quickly as possible following BATSE bursts. We have implemented a system which transmits the light curves of BACODINE/BATSE bursts directly by e-mail to UC Berkeley immediately after detection. An automatic e-mail parser at Berkeley watches for these notices, determines the Ulysses crossing time window, and initiates a search for the burst data on the JPL computer as they are received. In ideal cases, it is possible to retrieve the Ulysses data within a few hours of a burst, generate an annulus of arrival directions, and e-mail it out to the astronomical community by local nightfall. Human operators remain in this loop, but we are developing a fully automated routine which should remove them, at least for intense events, and reduce turn-around times to an absolute minimum. We explain the current operations, the data types used, and the speed/accuracy tradeoffs.

  3. Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer.

    PubMed

    Park, Ji Hyun; Choi, Yun Jung; Kim, Seon Ye; Lee, Jung-Eun; Sung, Ki Jung; Park, Sojung; Kim, Woo Sung; Song, Joon Seon; Choi, Chang-Min; Sung, Young Hoon; Rho, Jin Kyung; Lee, Jae Cheol

    2016-04-19

    Mutant-selective, 3rd-generation EGFR-TKIs were recently developed to control lung cancer cells harboring T790M-mediated resistance. However, the development of resistance to these novel drugs seems inevitable. Thus, we investigated the mechanism of acquired resistance to the mutant-selective EGFR-TKI WZ4002. We established five WZ4002-resistant cells, derived from cells harboring both EGFR and T790M mutations by long-term exposure to increasing doses of WZ4002. Compared with the parental cells, all resistant cells showed 10-100-folds higher resistance to WZ4002, as well as cross-resistance to other mutant-selective inhibitors. Among them, three resistant cells (HCC827/WR, PC-9/WR and H1975/WR) showed dependency on EGFR signaling, but two other cells (PC-9/GR/WR and PC-9/ER/WR) were not. Notably, insulin-like growth factor-1 receptor (IGF1R) was aberrantly activated in PC-9/GR/WR cells in phospho-receptor tyrosine kinase array, consistently accompanied by loss of IGF binding protein-3 (IGFBP3). Down-regulation of IGF1R by shRNA, as well as inhibition of IGF1R activity either by AG-1024 (a small molecule IGF1R inhibitor) or BI 836845 (a monoclonal anti-IGF1/2 blocking antibody), restored the sensitivity to WZ4002 both in vitro and xenograft. Taken together, these results suggest that activation of the IGF1R pathway associated with IGFBP3 loss can induce an acquired resistance to the mutant-selective EGFR-TKI, WZ4002. Therefore, a combined therapy of IGF1R inhibitors and mutant-selective EGFR-TKIs might be a viable treatment strategy for overcoming acquired resistance. PMID:26980747

  4. Activation of the IGF1R pathway potentially mediates acquired resistance to mutant-selective 3rd-generation EGF receptor tyrosine kinase inhibitors in advanced non-small cell lung cancer

    PubMed Central

    Park, Ji Hyun; Choi, Yun Jung; Kim, Seon Ye; Lee, Jung-Eun; Sung, Ki Jung; Park, Sojung; Kim, Woo Sung; Song, Joon Seon; Choi, Chang-Min; Sung, Young Hoon; Rho, Jin Kyung; Lee, Jae Cheol

    2016-01-01

    Mutant-selective, 3rd-generation EGFR-TKIs were recently developed to control lung cancer cells harboring T790M-mediated resistance. However, the development of resistance to these novel drugs seems inevitable. Thus, we investigated the mechanism of acquired resistance to the mutant-selective EGFR-TKI WZ4002. We established five WZ4002-resistant cells, derived from cells harboring both EGFR and T790M mutations by long-term exposure to increasing doses of WZ4002. Compared with the parental cells, all resistant cells showed 10–100-folds higher resistance to WZ4002, as well as cross-resistance to other mutant-selective inhibitors. Among them, three resistant cells (HCC827/WR, PC-9/WR and H1975/WR) showed dependency on EGFR signaling, but two other cells (PC-9/GR/WR and PC-9/ER/WR) were not. Notably, insulin-like growth factor-1 receptor (IGF1R) was aberrantly activated in PC-9/GR/WR cells in phospho-receptor tyrosine kinase array, consistently accompanied by loss of IGF binding protein-3 (IGFBP3). Down-regulation of IGF1R by shRNA, as well as inhibition of IGF1R activity either by AG-1024 (a small molecule IGF1R inhibitor) or BI 836845 (a monoclonal anti-IGF1/2 blocking antibody), restored the sensitivity to WZ4002 both in vitro and xenograft. Taken together, these results suggest that activation of the IGF1R pathway associated with IGFBP3 loss can induce an acquired resistance to the mutant-selective EGFR-TKI, WZ4002. Therefore, a combined therapy of IGF1R inhibitors and mutant-selective EGFR-TKIs might be a viable treatment strategy for overcoming acquired resistance. PMID:26980747

  5. Search for 3rd Generation Vector Leptoquarks in the Di-tau Di-jet Channel in Proton Antiproton Collisions at square root s = 1.96 TeV

    SciTech Connect

    Forrester, Stanley Scott; /UC, Davis

    2006-12-01

    We search for third generation vector leptoquarks (V LQ3) produced in colliding p{bar p} beams operating at {radical}s = 1.96 TeV at the CDF experiment in Run II of the Fermilab Tevatron. We use 322 pb{sup -1} of data to search for the V LQ3 signal in the di-tau plus di-jet channel. For the first time, the full matrix element is used in the Monte Carlo simulation of this signal. With no events observed in the signal region, we set a 95% C.L. upper limit on the V LQ3 pair production cross section of {sigma} < 344fb, assuming Yang-Mills couplings and Br(V LQ3 {yields} b{tau}) = 1, and a lower limit on the V LQ3 mass of m{sub V LQ3} > 317 GeV=c{sup 2}. If theoretical uncertainties on the cross section are applied in the least favorable manner the results are {sigma} < 360fb and m{sub V LQ3} > 294 GeV=c{sup 2}. The Minimal coupling V LQ3 result is an upper limit on the cross section of {sigma} < 493fb ({sigma} < 610fb) and the lower limit on the mass is m{sub V LQ3} > 251 GeV=c{sup 2} (m{sub V LQ3} > 223 GeV=c{sup 2}) for the nominal (1{sigma} varied) theoretical expectation.

  6. PREFACE: 3rd International Congress on Mechanical Metrology (CIMMEC2014)

    NASA Astrophysics Data System (ADS)

    2015-10-01

    From October 14th to 16th 2014, The Brazilian National Institute of Metrology, Quality, and Technology (Inmetro) and the Brazilian Society of Metrology (SBM) organized the 3rd International Congress on Mechanical Metrology (3rd CIMMEC). The 3rd CIMMEC was held in the city of Gramado, Rio Grande do Sul, Brazil. Anticipating the interest and enthusiasm of the technical-scientific community, the Organizing Institutions invite people and organizations to participate in this important congress, reiterating the commitment to organize an event according to highest international standards. This event has been conceived to integrate people and organizations from Brazil and abroad in the discussion of advanced themes in metrology. Manufacturers and dealers of measuring equipment and standards, as well as of auxiliary accessories and bibliographic material, had the chance to promote their products and services in stands at the Fair, which has taken place alongside the Congress. The 3rd CIMMEC consisted of five Keynote Speeches and 116 regular papers. Among the regular papers, the 25 most outstanding ones, comprising a high quality content on Mechanical Metrology, were selected to be published in this issue of Journal of Physics: Conference Series. It is our great pleasure to present this volume of Journal of Physics: Conference Series to the scientific community to promote further research in Mechanical Metrology and related areas. We believe that this volume will be both an excellent source of scientific material in the fast evolving fields that were covered by CIMMEC 2014.

  7. National--Alliance for Arts Education; JDR 3rd Fund

    ERIC Educational Resources Information Center

    Rogers, Forbes W.; Bloom, Kathryn

    1978-01-01

    The Alliance for Arts Education is an educational project embracing organizations and individuals at the national, state, and local levels with a mutual commitment to the arts as an integral part of the educational process. The JDR 3rd Fund provides consultant and technical services and, through coordination of the League of Cities for the Arts in…

  8. 75 FR 55313 - Record of Decision (ROD) for Conversion of the 3rd Armored Cavalry Regiment (3rd ACR) to a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-10

    ... Department of the Army Record of Decision (ROD) for Conversion of the 3rd Armored Cavalry Regiment (3rd ACR...: Notice of Availability (NOA). SUMMARY: The Department of the Army announces a ROD for conversion of the... conversion, the 3rd ACR will provide the Army with a force structure that has the flexibility to...

  9. 3rd latin american and Caribbean congress on health economics.

    PubMed

    Pérez Izquierdo, Victoria; Alvarez Muñiz, Manuel

    2009-02-01

    The 3rd Latin American and Caribbean Congress on Health Economics took place at Havana Convention Center from 28th to 31st October 2008. The conference was an excellent opportunity for the exchange of personal encounters regarding health economics and its related disciplines from the perspectives of research, teaching and management. Specialists from mostly Latin American countries attended the event. High-ranking specialists from other countries highlighted the importance and popularity of the conference. A total of 313 delegates from 23 countries were present at the congress, 160 of whom were Cuban. PMID:19371176

  10. PREFACE: 3rd International Congress on Ceramics (ICC3)

    NASA Astrophysics Data System (ADS)

    Niihara, Koichi; Ohji, Tatsuki; Sakka, Yoshio

    2011-10-01

    Early in 2005, the American Ceramic Society, the European Ceramic Society and the Ceramic Society of Japan announced a collaborative effort to provide leadership for the global ceramics community that would facilitate the use of ceramic and glass materials. That effort resulted in an agreement to organize a new biennial series of the International Congress on Ceramics, convened by the International Ceramic Federation (ICF). In order to share ideas and visions of the future for ceramic and glass materials, the 1st International Congress on Ceramics (ICC1) was held in Canada, 2006, under the organization of the American Ceramic Society, and the 2nd Congress (ICC2) was held in Italy, 2008, hosted by the European Ceramic Society. Organized by the Ceramic Society of Japan, the 3rd Congress (ICC3) was held in Osaka, Japan, 14-18 November 2010. Incorporating the 23rd Fall Meeting of the Ceramic Society of Japan and the 20th Iketani Conference, ICC3 was also co-organized by the Iketani Science and Technology Foundation, and was endorsed and supported by ICF, Asia-Oceania Ceramic Federation (AOCF) as well as many other organizations. Following the style of the previous two successful Congresses, the program was designed to advance ceramic and glass technologies to the next generation through discussion of the most recent advances and future perspectives, and to engage the worldwide ceramics community in a collective effort to expand the use of these materials in both conventional as well as new and exciting applications. ICC3 consisted of 22 voluntarily organized symposia in the most topical and essential themes of ceramic and glass materials, including Characterization, design and processing technologies Electro, magnetic and optical ceramics and devices Energy and environment related ceramics and systems Bio-ceramics and bio-technologies Ceramics for advanced industry and safety society Innovation in traditional ceramics It also contained the Plenary Session and the

  11. 3rd grade English language learners making sense of sound

    NASA Astrophysics Data System (ADS)

    Suarez, Enrique; Otero, Valerie

    2013-01-01

    Despite the extensive body of research that supports scientific inquiry and argumentation as cornerstones of physics learning, these strategies continue to be virtually absent in most classrooms, especially those that involve students who are learning English as a second language. This study presents results from an investigation of 3rd grade students' discourse about how length and tension affect the sound produced by a string. These students came from a variety of language backgrounds, and all were learning English as a second language. Our results demonstrate varying levels, and uses, of experiential, imaginative, and mechanistic reasoning strategies. Using specific examples from students' discourse, we will demonstrate some of the productive aspects of working within multiple language frameworks for making sense of physics. Conjectures will be made about how to utilize physics as a context for English Language Learners to further conceptual understanding, while developing their competence in the English language.

  12. PREFACE: 3rd International Conference on Hadron Physics (TROIA'11)

    NASA Astrophysics Data System (ADS)

    Erkol, Güray; Küçükarslan, Ayşe; Özpineci, Altuğ

    2012-03-01

    The 3rd International Conference on Hadron Physics, TROIA'11 was held at Canakkale, Turkey on 22-25 August 2011. Ozyegin University, Middle East Technical University, Canakkale Onsekiz Mart University and HadronPhysics2 Consortium sponsored the conference. Its aim was to bring together the experts and young scientists working on experimental and theoretical hadron physics. About 60 participants from 12 countries attended the conference. The topics covered included: Chiral Perturbation Theory QCD Sum Rules Effective Field Theory Exotic Hadrons Hadron Properties from Lattice QCD Experimental Results and Future Perspectives Hadronic Distribution Amplitudes The conference presentations were organized such that the morning sessions contained invited talks and the afternoon sessions were devoted to contributed talks and poster presentations. The speakers of the invited talks were: D Melikhov, M Nielsen, M Oka, E Oset, S Scherer, T T Takahashi and R Wanke. The conference venue was a resort hotel near Canakkale. As a social program, a guided full-day excursion to the excavation site of the ancient town of Troia and Assos was organized. We believe that this conference provided a medium for young scientists and experts in the field to effectively communicate and share ideas. We would like to express our sincere thanks to all participants for their contributions and stimulating discussions. We are also grateful to the Scientific Secretary, Kadir Utku Can, and all other members of the Organizing Committee for their patience and efforts. 13 February 2012 The Editors Güray Erkol Ayşe Küçükarslan Altuğ Özpineci Conference photograph

  13. PREFACE: 3rd International Meeting on Silicene (IMS-3)

    NASA Astrophysics Data System (ADS)

    Kara, Abdelkader; Enriquez, Hanna; Lemaire, Jean Louis; Oughaddou, Hamid

    2014-03-01

    . Historical summary Every two years, the STARM (science, technologie avanc\\'ee et recherche pour la Mediterran\\'ee, http://www.starm.emcmre.org/) society is organizing an international conference entitled Euro-Mediterranean Conference on Materials and Renewable Energies (EMCMRE, http://www.emcmre.org/) in countries across the Mediterranean Sea. It is in this framework that an international meeting dedicated to silicene is organized simultaneously since 2010: 1st International Meeting of Silicene (IMS-1), Safi, Morocco, 2010 2nd International Meeting of Silicene (IMS-2), Marrakech, Morocco, 2011 3rd International Meeting of Silicene (IMS-3), Istres-Marseille, France, 2013 Conference pictures are available in the PDF

  14. PREFACE: 3rd International Symposium ''Optics and its Applications''

    NASA Astrophysics Data System (ADS)

    Calvo, M. L.; Dolganova, I. N.; Gevorgyan, N.; Guzman, A.; Papoyan, A.; Sarkisyan, H.; Yurchenko, S.

    2016-01-01

    The SPIE.FOCUS Armenia: 3rd International Symposium ''Optics and its Applications'' (OPTICS-2015) http://rau.am/optics2015/ was held in Yerevan, Armenia, in the period October 1 - 5, 2015. The symposium was organized by the International Society for Optics and Photonics (SPIE), the Armenian SPIE student chapter with collaboration of the Armenian TC of ICO, the Russian-Armenian University (RAU), the Institute for Physical Research of National Academy of Sciences of Armenia (IPR of NAS), the Greek-Armenian industrial company LT-PYRKAL, and the Yerevan State University (YSU). The Symposium was co-organized by the SPIE & OSA student chapters of BMSTU, the Armenian OSA student chapter, and the SPIE student chapters of Lund University and Wroclaw University of Technology. The symposium OPTICS-2015 was dedicated to the International Year of Light and Light-Based Technologies. OPTICS-2015 was devoted to modern topics and optical technologies such as: optical properties of nanostructures, silicon photonics, quantum optics, singular optics & its applications, laser spectroscopy, strong field optics, biomedical optics, nonlinear & ultrafast optics, photonics & fiber optics, and mathematical methods in optics. OPTICS-2015 was attended by 100 scientists and students representing 17 countries: Armenia, China, Czech Republic, France, Georgia, Germany, India, Iran, Italy, Latvia, Mexico, Poland, Russia, Saudi Arabia, Sweden, Ukraine, and USA. Such a broad international community confirmed the important mission of science to be a uniting force between different countries, religions, and nations. We hope that OPTICS-2015 inspired and motivated students and young scientists to work in optics and in science in general. The present volume of Journal of Physics: Conference Series includes proceedings of the symposium covering various aspects of modern problems in optics. We are grateful to all people who were involved in the organization process. We gratefully acknowledge support from

  15. An Evidence-Based Approach to Estimating the National and State Costs of PreK-3rd. FCD Policy Brief Advancing PK-3rd. No.10

    ERIC Educational Resources Information Center

    Picus, Lawrence O.; Odden, Allan; Goetz, Michael

    2009-01-01

    This study estimates the costs of providing a high-quality PreK-3rd education approach in all 50 states plus the District of Columbia. Relying on an Evidence-Based approach to school finance adequacy, it identifies the staffing resources needed to offer high-quality integrated PreK-3rd programs and then estimates the costs of those resources. By…

  16. 80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    80. GENERAL VIEW TO NORTH ON 3RD AVENUE EL AT GUN HILL STATION. 7TH AVENUE EL EXPRESS IS VISIBLE ABOVE THE 3RD AVENUE EL WHICH JOINED ONTO THE SAME STRUCTURE AT GUN HILL ROAD. NOTE: GUN HILL ROAD IS THE NORTH TERMINUS OF THE 3RD AVENUE ELEVATED. TRAINS DID NOT CARRY PASSENGERS BEYOND THIS POINT, ALTHOUGH THE 3RD AVENUE TRACK DID EXTEND FURTHER NORTH FOR SWITCHING PURPOSES AND INTO THE YARDS. - Interborough Rapid Transit Company, Third Avenue Elevated Line, Borough of the Bronx, New York County, NY

  17. Effects of 2G and 3G mobile phones on human alpha rhythms: Resting EEG in adolescents, young adults, and the elderly.

    PubMed

    Croft, R J; Leung, S; McKenzie, R J; Loughran, S P; Iskra, S; Hamblin, D L; Cooper, N R

    2010-09-01

    The present study was conducted to determine whether adolescents and/or the elderly are more sensitive to mobile phone (MP)-related bioeffects than young adults, and to determine this for both 2nd generation (2G) GSM, and 3rd generation (3G) W-CDMA exposures. To test this, resting alpha activity (8-12 Hz band of the electroencephalogram) was assessed because numerous studies have now reported it to be enhanced by MP exposure. Forty-one 13-15 year olds, forty-two 19-40 year olds, and twenty 55-70 year olds were tested using a double-blind crossover design, where each participant received Sham, 2G and 3G exposures, separated by at least 4 days. Alpha activity, during exposure relative to baseline, was recorded and compared between conditions. Consistent with previous research, the young adults' alpha was greater in the 2G compared to Sham condition, however, no effect was seen in the adolescent or the elderly groups, and no effect of 3G exposures was found in any group. The results provide further support for an effect of 2G exposures on resting alpha activity in young adults, but fail to support a similar enhancement in adolescents or the elderly, or in any age group as a function of 3G exposure. PMID:20564174

  18. International directory of electric utilities, 3rd Edition

    SciTech Connect

    Not Available

    1991-01-01

    The book covers 162 countries in Europe, Asia, Africa, Middle East, and Latin America. It contains hundreds of names of key utility executives, utility addresses, plus telephone, fax, and telex numbers. Power plant construction plants, new T D facilities and lines, names of major plants plus their locations, capacity, fuels, type of generation, etc. are included. It also includes listing of international engineering consultants and key executives, translations of key technical terms, and maps showing key facilities for all countries.

  19. 19. MILL NO. 1, 3rd FLOOR, CEILING TRACKING WITH AIR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. MILL NO. 1, 3rd FLOOR, CEILING TRACKING WITH AIR CLEANER (BLEW DUST/LINT DOWNWARD WHILE TRAVELING ON TRACK OVER MILL MACHINERY). - Prattville Manufacturing Company, Number One, 242 South Court Street, Prattville, Autauga County, AL

  20. 1. WEST SIDE AND ENTRY, FROM ACROSS 3RD STREET, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. WEST SIDE AND ENTRY, FROM ACROSS 3RD STREET, LOOKING EAST. - Oakland Naval Supply Center, Administration Building-Dental Annex-Dispensary, Between E & F Streets, East of Third Street, Oakland, Alameda County, CA

  1. 19. OFFSHORE VIEW OF 3RD TEE, LOOKING NORTHWEST, SHOWING SOUTHEAST ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    19. OFFSHORE VIEW OF 3RD TEE, LOOKING NORTHWEST, SHOWING SOUTHEAST SIDE OF TACKLE BOX IN FOREGROUND - Huntington Beach Municipal Pier, Pacific Coast Highway at Main Street, Huntington Beach, Orange County, CA

  2. 15. OFFSHORE VIEW OF PIER, LOOKING EASTNORTHEAST, 3RD TEE, SHOWING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    15. OFFSHORE VIEW OF PIER, LOOKING EAST-NORTHEAST, 3RD TEE, SHOWING RESTROOMS IN FOREGROUND WITH PUMPHOUSE AND TACKLE BOX BEHIND - Huntington Beach Municipal Pier, Pacific Coast Highway at Main Street, Huntington Beach, Orange County, CA

  3. Visual, Critical, and Scientific Thinking Dispositions in a 3rd Grade Science Classroom

    NASA Astrophysics Data System (ADS)

    Foss, Stacy

    Many American students leave school without the required 21st century critical thinking skills. This qualitative case study, based on the theoretical concepts of Facione, Arheim, and Vygotsky, explored the development of thinking dispositions through the arts in science on the development of scientific thinking skills when used as a conceptual thinking routine in a rural 3rd grade classroom. Research questions examined the disposition to think critically through the arts in science and focused on the perceptions and experiences of 25 students with the Visual Thinking Strategy (VTS) process. Data were collected from classroom observations (n = 10), student interviews (n = 25), teacher interviews ( n = 1), a focus group discussion (n = 3), and artifacts of student work (n = 25); these data included perceptions of VTS, school culture, and classroom characteristics. An inductive analysis of qualitative data resulted in several emergent themes regarding disposition development and students generating questions while increasing affective motivation. The most prevalent dispositions were open-mindedness, the truth-seeking disposition, the analytical disposition, and the systematicity disposition. The findings about the teachers indicated that VTS questions in science supported "gradual release of responsibility", the internalization of process skills and vocabulary, and argumentation. This case study offers descriptive research that links visual arts inquiry and the development of critical thinking dispositions in science at the elementary level. A science curriculum could be developed, that emphasizes the development of thinking dispositions through the arts in science, which in turn, could impact the professional development of teachers and learning outcomes for students.

  4. Survey of K-3rd-Grade Teachers' Knowledge of Ear Infections and Willingness to Participate in Prevention Programs

    ERIC Educational Resources Information Center

    Danhauer, Jeffrey L.; Johnson, Carole E.; Caudle, Abby T.

    2011-01-01

    Purpose: Ear infections are prevalent in kindergarten through 3rd-grade (K-3rd) children and can affect their performance at school. Chewing gum, when administered by parents and teachers, can help prevent ear infections in children. This pilot study surveyed K-3rd-grade teachers in the Santa Barbara School Districts to assess their knowledge…

  5. Radiographic findings on 3rd molars removed in 20-year-old men.

    PubMed

    Rajasuo, Ari; Peltola, Jaakko; Ventä, Irja; Murtomaa, Heikki

    2003-10-01

    In this study we assess radiographic findings characteristic of mandibular 3rd molars that had required either routine or surgical extraction. X-ray findings relating to acute pericoronitis were also examined. The material was collected by investigating patient records and rotational panoramic radiographs of 20-year-old Finnish male conscripts (n = 738) treated during military service because of 3rd-molar-related problems. The follicle around the crown of mandibular 3rd molars with acute pericoronitis was enlarged in 19% of cases and in 13% of chronic symptom-free pericoronitis cases (not statistically significant difference). Mandibular 3rd molars extracted surgically were more often mesially inclined than those extracted routinely (61% vs. 23%; P < 0.001), partially or totally intrabony impacted (92% vs. 66%; P < 0.001) and deep situated (on average 4.2 mm vs. 2.5 mm under the occlusal plane). Surgical extraction was also associated with the roots completely developed [92% vs. 84% of the teeth routinely extracted, odds ratio (OR) 2.6, 95% confidence interval (CI) 1.2-5.5] and with the absence of radiographic pericoronitis [around 27% vs. 39% of the teeth routinely extracted (OR 0.5, 95% CI 0.3-0.8)]. In 86% of cases the space between 2nd molar and ramus of the mandible was narrower than the 3rd molar extracted surgically, whereas this was 62% in routine extraction cases (P < 0.001). We conclude that there are some typical 3rd-molar findings in rotational panoramic radiographs that show a need for surgical extraction. PMID:14763776

  6. Using Food as a Tool to Teach Science to 3rd Grade Students in Appalachian Ohio

    ERIC Educational Resources Information Center

    Duffrin, Melani W.; Hovland, Jana; Carraway-Stage, Virginia; McLeod, Sara; Duffrin, Christopher; Phillips, Sharon; Rivera, David; Saum, Diana; Johanson, George; Graham, Annette; Lee, Tammy; Bosse, Michael; Berryman, Darlene

    2010-01-01

    The Food, Math, and Science Teaching Enhancement Resource (FoodMASTER) Initiative is a compilation of programs aimed at using food as a tool to teach mathematics and science. In 2007 to 2008, a foods curriculum developed by professionals in nutrition and education was implemented in 10 3rd-grade classrooms in Appalachian Ohio; teachers in these…

  7. PreK-3rd: What Is the Price Tag? Policy to Action Brief. No. 2

    ERIC Educational Resources Information Center

    Shore, Rima

    2009-01-01

    In an era of intense fiscal pressures, educators are focusing on those investments most likely to lift student achievement. They are also trying to make more strategic use of existing resources. To achieve these goals, a growing number of policymakers are considering integrated PreK-3rd approaches. Increasingly, they are recognizing that the first…

  8. Patient protection at risk in IEC 60601-1 3rd edition.

    PubMed

    Dybdahl, K

    2009-09-01

    Engineers developing medical electrical equipment in accordance with IEC 60601-1 3rd edition are in immediate need of short- and long-term solutions to avoid potentially hazardous designs as a result of misinterpretation of the requirements. Several options are described to ensure consistency and safety of devices. PMID:19852179

  9. Evaluation of the "Respect Not Risk" Firearm Safety Lesson for 3rd-Graders

    ERIC Educational Resources Information Center

    Liller, Karen D.; Perrin, Karen; Nearns, Jodi; Pesce, Karen; Crane, Nancy B.; Gonzalez, Robin R.

    2003-01-01

    The purpose of this study was to evaluate the MORE HEALTH "Respect Not Risk" Firearm Safety Lesson for 3rd-graders in Pinellas County, Florida. Six schools representative of various socioeconomic levels were selected as the test sites. Qualitative and quantitative data were collected. A total of 433 matched pretests/posttests were used to…

  10. 75 FR 34450 - Filing Dates for the Indiana Special Election in the 3rd Congressional District

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-17

    ... From the Federal Register Online via the Government Publishing Office FEDERAL ELECTION COMMISSION Filing Dates for the Indiana Special Election in the 3rd Congressional District AGENCY: Federal Election Commission. ACTION: Notice of filing dates for special election. SUMMARY: Indiana has scheduled a...

  11. Prediction of High School Dropout or Graduation from 3rd Grade Data.

    ERIC Educational Resources Information Center

    Lloyd, Dee Norman; Bleach, Gail

    Measures of background characteristics, school performance, and tested achievement were analyzed for four race-by-sex samples of 3rd graders who were known to have later become high school dropouts or graduates. Results showed that as early as five to eight years before leaving school, dropouts differed significantly from graduates in age, tested…

  12. AL State Profile. Alabama: Alabama High School Graduation Exam (AHSGE), 3rd Edition

    ERIC Educational Resources Information Center

    Center on Education Policy, 2010

    2010-01-01

    This paper provides information about Alabama High School Graduation Exam, 3rd Edition, a comprehensive standards-based exam. The purpose of the exam is to: (1) Provide schools with student academic diagnostic information; (2) Determine prospective high school graduates' mastery of the state curriculum; (3) Increase alignment of local curriculum…

  13. 16. 3RD FLOOR, J.M. LEHMANN CO. FIVEROLL TOILET SOAP MILL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    16. 3RD FLOOR, J.M. LEHMANN CO. FIVE-ROLL TOILET SOAP MILL INSTALLED 1950, TO WEST; BUCKET CONVEYOR AT RIGHT MOVED WASTE FROM 2ND FLOOR SOAP PRESSES TO 5TH FLOOR RE-MANUFACTURE - Colgate & Company Jersey City Plant, Building No. B-14, 54-58 Grand Street, Jersey City, Hudson County, NJ

  14. Linking Learning: The PreK-3rd Path to School Success

    ERIC Educational Resources Information Center

    Advocates for Children of New Jersey, 2010

    2010-01-01

    Giving children high-quality preschool is the first step in the journey to school success. The next steps--kindergarten through 3rd grade--are equally important. Advocates for Children of New Jersey (ACNJ) is working on several fronts to help school districts across the state build strong early learning programs, which can significantly improve…

  15. 78. VIEW OF 3RD TEE, TAKEN FROM SOUTHEAST SIDE OF ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    78. VIEW OF 3RD TEE, TAKEN FROM SOUTHEAST SIDE OF PIER, FACING SOUTHWEST, SHOWING NORTHEAST SIDE OF THE TACKLE BOX (LEFT), SOUTHEAST SIDE AND NORTHEAST FRONT OF PUMPHOUSE (RIGHT), AND RESTROOMS IN BACKGROUND - Huntington Beach Municipal Pier, Pacific Coast Highway at Main Street, Huntington Beach, Orange County, CA

  16. Design and Experimental Evaluation of a 3rd Generation Addressable CMOS Piezoresistive Stress Sensing Test Chip

    SciTech Connect

    Sweet, J.N.; Peterson, D.W.; Hsia, A.H.

    1999-04-13

    Piezoresistive stress sensing chips have been used extensively for measurement of assembly related die surface stresses. Although many experiments can be performed with resistive structures which are directly bonded, for extensive stress mapping it is necessary to have a large number of sensor cells which can be addressed using CMOS logic circuitry. Our previous test chip, the ATC04, has 100 cells, each approximately 0.012 in. on a side, on a chip with a side dimension of 0.45 in. When a cell resistor is addressed, it is connected to a four terminal measurement bus through CMOS transmission gates. In theory, the gate resistances do not affect the measurement. In practice, there may be subtle effects which appear when very high accuracy is required. At high temperatures, gate leakage can increase to a point at which the resistor measurement becomes inaccurate. For ATC04 this occurred at or above 50 C. Here, we report on the first measurements obtained with a new prototype test chip, the ATC06. This prototype was fabricated in a 0.5 micron feature size silicided CMOS process using the MOSIS prototyping facility. The cell size was approximately 0.004 in. on a side. In order to achieve piezoresistive behavior for the implanted resistors it was necessary to employ a non-standard silicide ''blocking'' process. The stress sensitivity of both implanted and polysilicon blocked resistors is discussed. Using a new design strategy for the CMOS logic, it was possible to achieve a design in which only 5 signals had to be routed to a cell for addressing vs. 9 for ATC04. With our new design, the resistor under test is more effectively electrically isolated from other resistors on the chip, thereby improving high temperature performance. We present data showing operation up to 140 C.

  17. Correlates and Phenomenology of 1st and 3rd Person Memories

    PubMed Central

    Sutin, Angelina R.; Robins, Richard W.

    2010-01-01

    The present research addressed fundamental questions about the visual perspective of autobiographical memories: Are stable personality characteristics associated with visual perspective? Does visual perspective influence the memory's phenomenological qualities? Participants in Study 1 (N = 1,684) completed individual-difference measures and indicated the perspective from which they generally retrieve memories. Participants in Study 2 (N = 706) retrieved a memory from their natural or manipulated perspective, rated its phenomenology, and completed the same individual-difference measures. Dissociation and anxiety were associated with 3rd person retrieval style; the Big Five personality traits were primarily unrelated to perspective. Compared to 3rd person memories, naturally-occurring 1st person memories were higher on Vividness, Coherence, Accessibility, Sensory Detail, Emotional Intensity, and Time Perspective and lower on Distancing; manipulating perspective eliminated these differences. Visual perspective is associated with clinically-relevant constructs and, although associated with the memory's phenomenology, perspective does not shape it. PMID:20665336

  18. Conference report: the 3rd Global CRO Council for Bioanalysis at the International Reid Bioanalytical Forum.

    PubMed

    Breda, Massimo; Garofolo, Fabio; Caturla, Maria Cruz; Couerbe, Philippe; Maltas, John; White, Peter; Struwe, Petra; Sangster, Timothy; Riches, Suzanne; Hillier, Jim; Garofolo, Wei; Zimmerman, Thomas; Pawula, Maria; Collins, Eileen; Schoutsen, Dick; Wieling, Jaap; Green, Rachel; Houghton, Richard; Jeanbaptiste, Bernard; Claassen, Quinton; Harter, Tammy; Seymour, Mark

    2011-12-01

    The 3rd Global CRO Council Closed Forum was held on the 3rd and 4th July 2011 in Guildford, United Kingdom, in conjunction with the 19th International Reid Bioanalytical Forum. In attendance were 21 senior-level representatives from 19 CROs on behalf of nine European countries and, for many of the attendees, this occasion was the first time that they had participated in a GCC meeting. Therefore, this closed forum was an opportunity to increase awareness of the aim of the GCC and how it works, share information about bioanalytical regulations and audit findings from different agencies, their policies and procedures and also to discuss some topics of interest and aim to develop ideas and provide recommendations for bioanalytical practices at future GCC meetings in Europe. PMID:22185271

  19. 1st Central and Eastern European Proteomic Conference and 3rd Czech Proteomic Conference.

    PubMed

    Kovarova, Hana; Gadher, Suresh Jivan; Archakov, Alexander

    2008-02-01

    The 1st Central and Eastern European Proteomic Conference was organized together with the 3rd Czech Proteomic Conference in the TOP Hotel, Prague in the Czech Republic from the 29th to the 31st October, 2007. The aim was to strengthen links with scientists from Central and Eastern Europe including Russia, which until now have been weak or nonexistent, and to highlight the emergence of excellent proteomic studies from various countries, which until now were not visible. PMID:18282121

  20. Higher order modes of a 3rd harmonic cavity with an increased end-cup iris

    SciTech Connect

    T. Khabibouline; N. Solyak; R. Wanzenberg

    2003-05-19

    The cavity design for a 3rd harmonic cavity for the TTF 2 photoinjector has been revised to increase the coupling between the main coupler and the cavity cells. The iris radius of the end cup of the cavity has been increased to accomplish a better coupling. The basic rf-parameters and the higher order modes of the modified design are summarized in this report.

  1. What is FirstSchool? Issues in PreK-3rd Education. Number One

    ERIC Educational Resources Information Center

    Ritchie, Sharon; Maxwell, Kelly; Clifford, Richard

    2009-01-01

    FirstSchool is part of a national PreK-3rd movement of schools, districts, educators and universities seeking to improve how children from ages 3 to 8 learn and develop in schools. While these different projects use a variety of names, all are working to connect high-quality PreK programs with high-quality elementary schools. FirstSchool is…

  2. 13. Photocopy of 1920 drawing titled: BUILDING 78, 3RD FLOOR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    13. Photocopy of 1920 drawing titled: BUILDING 78, 3RD FLOOR BALCONY AND FIRE ESCAPES, including plans for skylight and North Elevation. HABS photograph is an 8x10' contact print made from a high contrast negative of an enlargement made from microfiche. Original is in the collection of Department of Public Works, Puget Sound Naval Shipyard, Bremerton, WA. - Puget Sound Naval Shipyard, Administration Building, Farragut Avenue, Bremerton, Kitsap County, WA

  3. Insights from the 3rd World Congress on Integrated Computational Materials Engineering

    NASA Astrophysics Data System (ADS)

    Howe, D.; Goodlet, B.; Weaver, J.; Spanos, G.

    2016-05-01

    The 3rd World Congress on Integrated Computational Materials Engineering (ICME) was a forum for presenting the "state-of-the-art" in the ICME discipline, as well as for charting a path for future community efforts. The event concluded with in an interactive panel-led discussion that addressed such topics as integrating efforts between experimental and computational scientists, uncertainty quantification, and identifying the greatest challenges for future workforce preparation. This article is a summary of this discussion and the thoughts presented.

  4. CLINICAL ASSESSMENT OF THE 1/3rd RADIUS USING A NEW DESKTOP ULTRASONIC BONE DENSITOMETER

    PubMed Central

    Stein, Emily M.; Rosete, Fernando; Young, Polly; Kamanda-Kosseh, Mafo; McMahon, Donald J.; Luo, Gangming; Kaufman, Jonathan J.; Shane, Elizabeth; Siffert, Robert S.

    2012-01-01

    The objectives of this study were to evaluate the capability of a novel ultrasound device to clinically estimate bone mineral density (BMD) at the 1/3rd radius. The device rests on a desktop and is portable, and permits real-time evaluation of the radial BMD. The device measures two (2) net time delay (NTD) parameters, NTDDW and NTDCW. NTDDW is defined as the difference between the transit time of an ultrasound pulse to travel through soft-tissue, cortex and medullary cavity, and the transit time through soft tissue only of equal overall distance. NTDCW is defined as the difference between the transit time of an ultrasound pulse to travel through soft-tissue and cortex only, and the transit time through soft tissue only again of equal overall distance. The square root of the product of these two parameters is a measure of the radial BMD at the 1/3rd location as measured by dual-energy x-ray absorptiometry (DXA). A clinical IRB-approved study measured ultrasonically sixty adults at the 1/3rd radius. BMD was also measured at the same anatomical site and time using DXA. A linear regression using NTD produced a linear correlation coefficient of 0.93 (P<0.001). These results are consistent with previously reported simulation and in vitro studies. In conclusion, although x-ray methods are effective in bone mass assessment, osteoporosis remains one of the largest undiagnosed and under-diagnosed diseases in the world today. The research described here should enable significant expansion of diagnosis and monitoring of osteoporosis through a desktop device that ultrasonically assesses bone mass at the 1/3rd radius. PMID:23312957

  5. 3rd Workshop on Semantic Ambient Media Experience (SAME) - In Conjunction with AmI-2010

    NASA Astrophysics Data System (ADS)

    Lugmayr, Artur; Stockleben, Bjoern; Kaario, Juha; Pogorelc, Bogdan; Risse, Thomas

    The SAME workshop takes place for the 3rd time in 2010, and it's theme in this year was creating the business value-creation, vision, media theories and technology for ambient media. SAME differs from other workshops due to its interactive and creative touch and going beyond simple powerpoint presentations. Several results will be published by AMEA - the AMbient Media Association (www.ambientmediaassociation.org.

  6. NURSING EMERGING. ANA Nursing: Scope and Standards of Practice, (2015) 3rd Edition.

    PubMed

    Mariano, Carla

    2016-04-01

    AHNA Past-President Carla Mariano recently had the privilege of serving on the American Nurses Association's (ANA) Nursing Scope and Standards Revision Workgroup. Representing the specialty practice of holistic nursing, Carla's presence within this workgroup contributed greatly to the inclusion of holistic principles and values throughout the new 2015 Nursing: Scope and Standards of Practice, 3rd edition, the foundational document that informs and guides professional nursing practice within the United States. This is a significant step forward for holistic nursing and an indicator of our growing influence as specialty practice. PMID:27305802

  7. Preface to Special Topic: Invited Papers of the 3rd International Conference on Ultrafast Structural Dynamics

    PubMed Central

    Johnson, S. L.

    2016-01-01

    The ability to visualize the real-time dynamics of atomic, magnetic, and electronic structure is widely recognized in many fields as a key element underpinning many important processes in chemistry, materials science, and biology. The need for an improved understanding of such processes becomes acute as energy conversion processes on fast time scales become increasingly relevant to problems in science and technology. This special issue, containing invited papers from participants at the 3rd International Conference on Ultrafast Structural Dynamics held June 10–12, 2015 in Zurich, Switzerland, discusses several recent developments in this area. PMID:27191008

  8. Preface to Special Topic: Invited Papers of the 3rd International Conference on Ultrafast Structural Dynamics.

    PubMed

    Johnson, S L

    2016-03-01

    The ability to visualize the real-time dynamics of atomic, magnetic, and electronic structure is widely recognized in many fields as a key element underpinning many important processes in chemistry, materials science, and biology. The need for an improved understanding of such processes becomes acute as energy conversion processes on fast time scales become increasingly relevant to problems in science and technology. This special issue, containing invited papers from participants at the 3rd International Conference on Ultrafast Structural Dynamics held June 10-12, 2015 in Zurich, Switzerland, discusses several recent developments in this area. PMID:27191008

  9. Overview of the 3rd isirv-Antiviral Group Conference – advances in clinical management

    PubMed Central

    Hurt, Aeron C; Hui, David S; Hay, Alan; Hayden, Frederick G

    2015-01-01

    This review highlights the main points which emerged from the presentations and discussions at the 3rd isirv-Antiviral Group Conference - advances in clinical management. The conference covered emerging and potentially pandemic influenza viruses and discussed novel/pre-licensure therapeutics and currently approved antivirals and vaccines for the control of influenza. Current data on approved and novel treatments for non-influenza respiratory viruses such as MERS-CoV, respiratory syncytial virus (RSV) and rhinoviruses and the challenges of treating immunocompromised patients with respiratory infections was highlighted. PMID:25399715

  10. PREFACE: 3rd International Workshop on Materials Analysis and Processing in Magnetic Fields (MAP3)

    NASA Astrophysics Data System (ADS)

    Sakka, Yoshio; Hirota, Noriyuki; Horii, Shigeru; Ando, Tsutomu

    2009-07-01

    The 3rd International Workshop on Materials Analysis and Processing in Materials Fields (MAP3) was held on 14-16 May 2008 at the University of Tokyo, Japan. The first was held in March 2004 at the National High Magnetic Field Laboratory in Tallahassee, USA. Two years later the second took place in Grenoble, France. MAP3 was held at The University of Tokyo International Symposium, and jointly with MANA Workshop on Materials Processing by External Stimulation, and JSPS CORE Program of Construction of the World Center on Electromagnetic Processing of Materials. At the end of MAP3 it was decided that the next MAP4 will be held in Atlanta, USA in 2010. Processing in magnetic fields is a rapidly expanding research area with a wide range of promising applications in materials science. MAP3 focused on the magnetic field interactions involved in the study and processing of materials in all disciplines ranging from physics to chemistry and biology: Magnetic field effects on chemical, physical, and biological phenomena Magnetic field effects on electrochemical phenomena Magnetic field effects on thermodynamic phenomena Magnetic field effects on hydrodynamic phenomena Magnetic field effects on crystal growth Magnetic processing of materials Diamagnetic levitation Magneto-Archimedes effect Spin chemistry Application of magnetic fields to analytical chemistry Magnetic orientation Control of structure by magnetic fields Magnetic separation and purification Magnetic field-induced phase transitions Materials properties in high magnetic fields Development of NMR and MRI Medical application of magnetic fields Novel magnetic phenomena Physical property measurement by Magnetic fields High magnetic field generation> MAP3 consisted of 84 presentations including 16 invited talks. This volume of Journal of Physics: Conference Series contains the proceeding of MAP3 with 34 papers that provide a scientific record of the topics covered by the conference with the special topics (13 papers) in

  11. Treatment of 3rd molar-induced periodontal defects with guided tissue regeneration.

    PubMed

    Oxford, G E; Quintero, G; Stuller, C B; Gher, M E

    1997-07-01

    Recent reports provide evidence of increased attachment levels when using guided tissue regeneration (GTR) techniques for the treatment of periodontal defects. Periodontal defects frequently occur at the distal aspect of mandibular 2nd molars which are next to mesioangular impacted 3rd molars that have oral communication. The purpose of this study was to determine whether the use of GTR can enhance probing attachment levels (PALs) following extraction of mesioangular impacted third molars. 12 patients with bilateral soft tissue impacted mandibular 3rd molars entered this split mouth study. After extractions, the previously exposed distal root surface of the 2nd molars were debrided. The defects on the randomly selected experimental sites were covered with expanded polytetraflouro-ethylene (e-PTFE) membrane and the tissue was replaced to cover the membrane. Membranes were removed after 6 weeks. Control sites were treated identically except no membrane was placed. GI, P1I, PD, PAL and BOP records were obtained at 0, 3 and 6 months. The use of barrier material did not provide statistically-significant differences in PAL when comparing experimental versus control sites. Nevertheless, PAL gain was consistently greater at 3 and 6 months when GTR techniques were used in sites with deep impactions. PMID:9226386

  12. Using food as a tool to teach science to 3rd grade students in Appalachian Ohio

    PubMed Central

    Duffrin, Melani W.; Hovland, Jana; Carraway-Stage, Virginia; McLeod, Sara; Duffrin, Christopher; Phillips, Sharon; Rivera, David; Saum, Diana; Johanson, George; Graham, Annette; Lee, Tammy; Bosse, Michael; Berryman, Darlene

    2010-01-01

    The Food, Math, and Science Teaching Enhancement Resource (FoodMASTER) Initiative is a compilation of programs aimed at using food as a tool to teach mathematics and science. In 2007–2008, a foods curriculum developed by professionals in nutrition and education was implemented in 10 3rd-grade classrooms in Appalachian Ohio; teachers in these classrooms implemented 45 hands-on foods activities that covered 10 food topics. Subjects included measurement; food safety; vegetables; fruits; milk and cheese; meat, poultry, and fish; eggs; fats; grains; and meal management. Students in four other classrooms served as the control group. Mainstream 3rd-grade students were targeted because of their receptiveness to the subject matter, science standards for upper elementary grades, and testing that the students would undergo in 4th grade. Teachers and students alike reported that the hands-on FoodMASTER curriculum experience was worthwhile and enjoyable. Our initial classroom observation indicated that the majority of students, girls and boys included, were very excited about the activities, became increasingly interested in the subject matter of food, and were able to conduct scientific observations. PMID:20975982

  13. PREFACE: 3rd International Symposium on Functional Materials 2009 (ISFM 2009) 3rd International Symposium on Functional Materials 2009 (ISFM 2009)

    NASA Astrophysics Data System (ADS)

    Kiwon, Kim; Li, Lu; Taehyun, Nam; Jouhyeon, Ahn

    2010-05-01

    The 3rd International Symposium on Functional Materials 2009 (ISFM 2009) and its preconference, Advances in Functional Materials 2009 (AFM 2009), were successfully held in the Republic of Korea from 15-18 June 2009 and in the People's Republic of China from 8-12 June 2009, respectively. The two conferences attracted over 300 oral and poster presentations from over 12 countries including Australia, Canada, China, Germany, Japan, India, Israel, Korea, The Netherlands, Thailand, the UK and the USA. In the two conferences, eight keynote lectures were delivered by S Miyazaki, S A Akbar, D J Singh, C Suryanarayana, M~Greenblatt, H Zhang, T Sato and J Ding. This topical issue of Physica Scripta contains papers presented at the ISFM 2009 and AFM 2009. Keyan Li from Dalian University, People's Republic of China, presents some empirical formulae to estimate the elastic moduli of rocksalt-, zincblende- and chalcopyrite-structured crystals, on the basis of electronegativities of bonded atoms in the crystallographic frame. Min-Jung Kim from Hanyang University, Korea, reports on the preparation and characterization of carboxyl functionalization of magnetite nanoparticles for oligonucleotide immobilization. F Yan from the National University of Singapore studies the fabrication of Bi(Fe0.5Sc0.5)O3-PbTiO3 (BSF-PT) thin films by pulsed laser deposition, and the enhanced magnetic moment with respect to BiFeO3-PbTiO3. Dong-Gil Lee from Pusan National University, Korea, reports on the sterilization of enteropathogenic Escherichia coli using nanofiber TiO2 films prepared by the electrostatic spray method. Sang-Eun Park from the Korea Institute of Science and Technology reports on the study of encapsulated Fe3O4 nanoparticles with a silica thin layer with a reversible capacity of about 363 mAhg-1. Other researchers report on many other exiting achievements in the fields of ferromagnetic materials, magneto-optical materials, thermoelectric materials, shape memory materials, fuel-cell and

  14. PREFACE: 3rd International Conference of Mechanical Engineering Research (ICMER 2015)

    NASA Astrophysics Data System (ADS)

    Mamat, Riazalman; Rahman, Mustafizur; Mohd. Zuki Nik Mohamed, Nik; Che Ghani, Saiful Anwar; Harun, Wan Sharuzi Wan

    2015-12-01

    The 3rd ICMER2015 is the continuity of the NCMER2010. The year 2010 represents a significant milestone in the history for Faculty of Mechanical Engineering, Universiti Malaysia Pahang (UMP) Malaysia with the organization of the first and second national level conferences (1st and 2nd NCMER) at UMP on May 26-27 and Dec 3-4 2010. The Faculty then changed the name from National Conference on Mechanical Engineering Research (NCMER) to International Conference on Mechanical Engineering Research (ICMER) in 2011 and this year, 2015 is our 3rd ICMER. These proceedings contain the selected scientific manuscripts submitted to the conference. It is with great pleasure to welcome you to the "International Conference on Mechanical Engineering Research (ICMER2015)" that is held at Zenith Hotel, Kuantan, Malaysia. The call for papers attracted submissions of over two hundred abstracts from twelve different countries including Japan, Iran, China, Kuwait, Indonesia, Norway, Philippines, Morocco, Germany, UAE and more. The scientific papers published in these proceedings have been revised and approved by the technical committee of the 3rd ICMER2015. All of the papers exhibit clear, concise, and precise expositions that appeal to a broad international readership interested in mechanical engineering, combustion, metallurgy, materials science as well as in manufacturing and biomechanics. The reports present original ideas or results of general significance supported by clear reasoning and compelling evidence, and employ methods, theories and practices relevant to the research. The authors clearly state the questions and the significance of their research to theory and practice, describe how the research contributes to new knowledge, and provide tables and figures that meaningfully add to the narrative. In this edition of ICMER representatives attending are from academia, industry, governmental and private sectors. The plenary and invited speakers will present, discuss, promote and

  15. Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting.

    PubMed

    Rubin, Seth M; Sage, Julien

    2013-01-01

    The retinoblastoma tumor suppressor (Rb) pathway is mutated in most, if not all human tumors. In the G0/G1 phase, Rb and its family members p107 and p130 inhibit the E2F family of transcription factors. In response to mitogenic signals, Cyclin-dependent kinases (CDKs) phosphorylate Rb family members, which results in the disruption of complexes between Rb and E2F family members and in the transcription of genes essential for S phase progression. Beyond this role in early cell cycle decisions, Rb family members regulate DNA replication and mitosis, chromatin structure, metabolism, cellular differentiation, and cell death. While the RB pathway has been extensively studied in the past three decades, new investigations continue to provide novel insights into basic mechanisms of cancer development and, beyond cancer, help better understand fundamental cellular processes, from plants to mammals. This meeting report summarizes research presented at the recently held 3rd International Rb Meeting. PMID:24257515

  16. Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting

    PubMed Central

    2013-01-01

    The retinoblastoma tumor suppressor (Rb) pathway is mutated in most, if not all human tumors. In the G0/G1 phase, Rb and its family members p107 and p130 inhibit the E2F family of transcription factors. In response to mitogenic signals, Cyclin-dependent kinases (CDKs) phosphorylate Rb family members, which results in the disruption of complexes between Rb and E2F family members and in the transcription of genes essential for S phase progression. Beyond this role in early cell cycle decisions, Rb family members regulate DNA replication and mitosis, chromatin structure, metabolism, cellular differentiation, and cell death. While the RB pathway has been extensively studied in the past three decades, new investigations continue to provide novel insights into basic mechanisms of cancer development and, beyond cancer, help better understand fundamental cellular processes, from plants to mammals. This meeting report summarizes research presented at the recently held 3rd International Rb Meeting. PMID:24257515

  17. Dental health in antique population of Vinkovci - Cibalae in Croatia (3rd-5th century).

    PubMed

    Peko, Dunja; Vodanović, Marin

    2016-08-01

    Roman city Cibalae (Vinkovci) - the birthplace of Roman emperors Valentinian I and Valens was a very well developed urban ares in the late antique what was evidenced by numerous archaeological findings. The aim of this paper is to get insight in dental health of antique population of Cibalae. One hundred individuals with 2041 teeth dated to 3rd - 5th century AD have been analyzed for caries, antemortem tooth loss, periapical diseases and tooth wear. Prevalence of antemortem tooth loss was 4.3% in males, 5.2% in females. Prevalence of caries per tooth was 8.4% in males, 7.0% in females. Compared to other Croatian antique sites, ancient inhabitants of Roman Cibalae had rather good dental health with low caries prevalence and no gender differences. Statistically significant difference was found between males in females in the prevalence of periapical lesions and degree of tooth wear. Periapical lesions were found only in males. PMID:27598951

  18. Evaluation of the "Respect Not Risk" firearm safety lesson for 3rd-graders.

    PubMed

    Liller, Karen D; Perrin, Karen; Nearns, Jodi; Pesce, Karen; Crane, Nancy B; Gonzalez, Robin R

    2003-12-01

    The purpose of this study was to evaluate the MORE HEALTH "Respect Not Risk" Firearm Safety Lesson for 3rd-graders in Pinellas County, Florida. Six schools representative of various socioeconomic levels were selected as the test sites. Qualitative and quantitative data were collected. A total of 433 matched pretests/posttests were used to determine the effectiveness of the class in increasing student knowledge about firearm safety. The results revealed a significant increase in the mean scores on the posttest compared with the pretest. Qualitative findings showed the lesson was positively received by both students and teachers, and 65% of responding students reported discussing the lesson with family members. School nurses are encouraged to take a leading role in promoting firearm injury prevention to students. PMID:14622039

  19. Passive solar progress: a simplified guide to the 3rd national passive solar conference

    SciTech Connect

    Miller, H.; Howell, Y.; Richards, D.

    1980-10-01

    Some of the concepts and practices that have come to be known as passive solar heating and cooling are introduced, and a current picture of the field is presented. Much of the material presented is derived from papers given at the 3rd National Passive Solar Conference held in San Jose, California in January 1979 and sponsored by the US Department of Energy. Extracts and data from these papers have been integrated in the text with explanatory and descriptive material. In this way, it is attempted to present technical information in an introductory context. Topics include design considerations, passive and hybrid systems and applications, sizing methods and performance prediction, and implementation issues. A glossary is included. (WHK)

  20. John D. Rockefeller 3rd, statesman and founder of the Population Council.

    PubMed

    Dunlop, J

    2000-01-01

    This article presents a profile of John D. Rockefeller 3rd, statesman and founder of the Population Council. It is noted that Rockefeller took a broad view of population control as a means to address poverty and economic development rather than as an end in itself. In 1952 he initiated the convocation of the Conference on Population Problems held in Williamsburg, Virginia. The discussion focused on food supply, industrial development, depletion of natural resources, and political instability resulting from unchecked population growth. In 1967, Rockefeller initiated, lobbied for, and finally achieved a World Leaders' Statement signed by 30 heads of state including US President Lyndon Johnson. The document drew attention to population growth as a world problem and engendered political support for family planning as a solution. After 3 years the Commission on Population Growth and the American Future was established, and Rockefeller was made its chairman. Several issues were debated, including more safer fertility control and the legalization of abortion. PMID:12349764

  1. Detection and clinical evolution of scrapie in sheep by 3rd eyelid biopsy.

    PubMed

    Vargas, Francisco; Luján, Lluís; Bolea, Rosa; Monleón, Eva; Martín-Burriel, Inmaculada; Fernández, Antonio; De Blas, Ignacio; Badiola, Juan José

    2006-01-01

    The goal of this article was to characterize the clinical evolution of scrapie in naturally affected sheep. Eighteen sheep with scrapie diagnosed by examination of 3rd eyelid biopsy and 12 control ewes were studied throughout the duration of their disease. Diagnosis was confirmed postmortem by histopathologic, immunohistochemical, and Western blot analysis of nervous tissue. Complete clinical examinations were performed every 2 weeks for each animal, of which 3 clinical examinations per animal are reported. Those clinical signs that showed a significant frequency within the corresponding clinical examination were considered representative of each stage of the disease (ie, early, middle, and late). The representative clinical signs for the early stage were hypoesthesia in the limbs, alteration of mental status, and a body condition score <3. Remarkably, hypoesthesia in the limbs was one of the 1st signs appearing during the early clinical stage in the affected animals, even before the appearance of other signs. For the middle stage, representative signs were the same as those for the early stage, together with hyporreflexia in the limbs, cardiac arrhythmia, pruritus/wool loss, and the appearance of the nibbling reflex. Representative clinical signs for the late stage were the same as those for the early and middle stage, together with head tremors, hyperexcitability to external stimuli, ataxia or gait abnormalities, and teeth grinding. On the basis of these results, we propose the calculation of an objective clinical index that allows the differentiation among clinical stages and that could be useful for further studies. The usefulness of 3rd eyelid lymphoid tissue biopsies for sequential clinical studies in naturally scrapie-affected sheep is demonstrated. PMID:16496940

  2. 3rd Quarter Transportation Report FY 2014: Radioactive Waste Shipments to and from the Nevada National Security Site (NNSS)

    SciTech Connect

    Gregory, Louis

    2014-09-20

    This report satisfies the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Field Office (NNSA/NFO) commitment to prepare a quarterly summary report of radioactive waste shipments to the Nevada National Security Site (NNSS) Radioactive Waste Management Complex (RWMC) at Area 5. There were no shipments sent for offsite treatment and returned to the NNSS this quarter. This report summarizes the 3rd quarter of Fiscal Year (FY) 2014 low-level radioactive waste (LLW) and mixed low-level radioactive waste (MLLW) shipments. This report also includes annual summaries for FY 2014 in Tables 4 and 5. Tabular summaries are provided which include the following: Sources of and carriers for LLW and MLLW shipments to and from the NNSS; Number and external volume of LLW and MLLW shipments; Highway routes used by carriers; and Incident/accident data applicable to LLW and MLLW shipments. In this report shipments are accounted for upon arrival at the NNSS, while disposal volumes are accounted for upon waste burial. The disposal volumes presented in this report do not include minor volumes of non-radioactive materials that were approved for disposal. Volume reports showing cubic feet generated using the Low-Level Waste Information System may vary slightly due to differing rounding conventions.

  3. APOBEC3G restricts early HIV-1 replication in the cytoplasm of target cells

    SciTech Connect

    Anderson, Jenny L.; Hope, Thomas J.

    2008-05-25

    Cellular APOBEC3G (A3G) protein is packaged into human immunodeficiency virus type 1 (HIV-1) virions in producer cells yet restricts viral replication in target cells. To characterize this restriction in target cells, the effect of A3G on generating various HIV-1 cDNA products was measured by quantitative real-time PCR. A3G decreased cDNA products from Vif-deficient HIV-1, with minor effects on early reverse transcripts and larger declines in late reverse transcripts. However, the greatest decline was typically observed in nuclear 2-LTR circles. Moreover, the magnitude of these declines varied with A3G dose. Adding integration inhibitor did not stop the A3G-mediated loss in 2-LTR circles. Moreover, obstructing HIV-1 nuclear entry using vesicular stomatitis virus matrix protein did not stop the A3G-mediated decline in late reverse transcripts. Collectively, these data suggest that A3G has important restriction activity in the cytoplasm and progressively diminishes viral cytoplasmic and nuclear cDNA forms with increasing magnitude during restriction.

  4. APOBEC3G ubiquitination by Nedd4-1 favors its packaging into HIV-1 particles.

    PubMed

    Dussart, Sylvie; Douaisi, Marc; Courcoul, Marianne; Bessou, Gilles; Vigne, Robert; Decroly, Etienne

    2005-01-21

    APOBEC3G is a cytidine deaminase that limits the replication of many retroviruses. This antiviral host factor is packaged into retrovirus particles, where it targets single-stranded DNA generated during reverse transcription and induces up to 2% of G-to-A mutations, which are lethal for the HIV-1 provirus. Vif protein counteracts this antiviral factor by decreasing its packaging into lentivirus particles. Here, we demonstrate that Nedd4-1, an HECT E3 ubiquitin ligase, interacts with APOBEC3G, through its WW2 and WW3 domains. As a result of this interaction, APOBEC3G undergoes post-translational modification by addition of ubiquitin moieties. Accordingly, we demonstrate that the dominant negative Nedd4-1 C/S form prevents APOBEC3G ubiquitination. Moreover, the packaging of APOBEC3G into Pr55 Gag virus-like particles and into HIV-1 virions is reduced when Nedd4-1 C/S is expressed. During HIV-1 viral production in the presence of APOBEC3G, Nedd4-1 C/S restores partially the infectivity of Deltavif HIV-1. We conclude that the ubiquitination of APOBEC3G by Nedd4-1 favors its targeting to the virus assembly site where APOBEC3G interacts with Gag and is packaged into HIV-1 particles in the absence of Vif. PMID:15581898

  5. The 3^rd International Conference on Women in Physics: Global Perspectives, Common Concerns, Worldwide Views

    NASA Astrophysics Data System (ADS)

    Zastavker, Yevgeniya V.

    2009-03-01

    The 3^rd International Conference on Women in Physics (ICWIP), held in Seoul, Korea, in October 2008, brought together 300 participants from 57 countries, including a diverse 22-member U.S. Delegation, for a 3-day summit of stimulating discussions, thought-provoking presentations, inspirational posters, and networking. Held under the auspices of the Working Group on Women in Physics of the International Union of Pure and Applied Physics (IUPAP), this meeting built on the successes of the 1^st (Paris, 2002) and 2^nd (Rio de Janeiro, 2005) Conferences and further clarified the importance of diversifying the field of physics worldwide. Although considerable progress has been made since 2002, it was clear that the global scientific workforce is still under-utilizing a large percentage of the available female talent pool. If human society is to benefit to its fullest from various contributions that the field of physics can offer in addressing global issues of economic crisis, energy, environment, water, health, poverty, and hunger, women of all races and nationalities need to become fully included and engaged in the national and international physical community. To address these and many other issues, the ICWIP unanimously approved a five-part resolution to IUPAP recommending actions to promote the recruitment, retention, and advancement of women in physics and related fields.

  6. Effects of notetaking instruction on 3rd grade student's science learning and notetaking behavior

    NASA Astrophysics Data System (ADS)

    Lee, Pai-Lin

    The research examined effects of notetaking instruction on elementary-aged students' ability to recall science information and notetaking behavior. Classes of 3rd grade students were randomly assigned to three treatment conditions, strategic notetaking, partial strategic notetaking, and control, for 4 training sessions. The effects of the notetaking instruction were measured by their performances on a test on science information taught during the training, a long-term free recall of the information, and number of information units recalled with or without cues. Students' prior science achievement was used to group students into two levels (high vs. low) and functioned as another independent variable in analysis. Results indicated significant treatment effect on cued and non-cued recall of the information units in favor of the strategy instruction groups. Students with higher prior achievement in science performed better on cued recall and long-term free recall of information. The results suggest that students as young as at the third grade can be instructed to develop the ability of notetaking that promotes their learning.

  7. Resurgence of duckweed research and applications: report from the 3rd International Duckweed Conference.

    PubMed

    Appenroth, Klaus-J; Sree, K Sowjanya; Fakhoorian, Tamra; Lam, Eric

    2015-12-01

    Duckweed, flowering plants in the Lemnaceae family, comprises the smallest angiosperms in the plant kingdom. They have some of the fastest biomass accumulation rates reported to date for plants and have the demonstrated ability to thrive on wastewater rich in dissolved organic compounds and thus could help to remediated polluted water resources and prevents eutrophication. With a high quality genome sequence now available and increased commercial interest worldwide to develop duckweed biomass for renewables such as protein and fuel, the 3rd International Duckweed Conference convened at Kyoto, Japan, in July of 2015, to update the community of duckweed researchers and developers on the progress in the field. In addition to sharing results and ideas, the conference also provided ample opportunities for new-comers as well as established workers in the field to network and create new aliances. We hope this meeting summary will also help to disseminate the key advances and observations that have been presented in this conference to the broader plant biology community in order to encourage increased cross-fertilization of ideas and technologies. PMID:26506824

  8. Measuring the cascade rate in anisotropic turbulence through 3rd order structure functions.

    NASA Astrophysics Data System (ADS)

    Verdini, Andrea; Landi, Simone; Hellinger, Petr

    2014-05-01

    We employ the Von-Karman-Howart-Yaglom-Politano-Poquet (KHYPP)law, to compute the cascade rate by means of 3rd order structure functions in homogeneous, forced, DNS at high resolution. We consider first the isotropic case (no guide field) and verify that the cascade rate is consistent with the dissipation rate. Then we consider an anisotropic case (with guide field) for which the isotropic KHYPP law does not apply. We compute the parallel and perpendicular cascade rates and find that the latter basically accounts for the total dissipation rate, as expected for anisotropic turbulence. Also, the cascade rate derived from the isotropic law is found to be a good approximation for the total cascade rate. Recent works have shown that the hypothesis of stationary turbulence must be probably relaxed in the solar wind. We present preliminary results on the measure of the cascade rate in the expanding solar wind, obtained with DNS of MHD turbulence in the expanding box model. Such model incorporates the basic physic of expansion thus inducing anisotropies driven by both the magnetic field and expansion, along with an energy decrease due to the conservation of linear invariants (angular momentum and magnetic flux). The correction due to non-stationary conditions is found to be important and to become negligible only at small scales, thus suggesting that solar wind measurements over- estimate the actual cascade rate.

  9. Report from the 3rd AIDS Impact Conference: culture, community, empowerment.

    PubMed

    Aggleton, P

    1997-10-01

    Presentations made at the 3rd AIDS Impact Conferences in June 1997 in Melbourne, Australia are summarized. The presentations focused on the importance of local beliefs, practices, and sexual cultures as factors that impact HIV risk. The three dominant themes of this conference were a concern for community, an emphasis on culture, and empowerment for the most vulnerable groups. Speakers illustrated the importance of culture as a factor in the form, context, and meaning of sex among young men and women in Thailand, Australia, Italy, Cambodia, and the United States. Studies conducted in correctional facilities illustrate how the culture of sex and substance use can intensify the HIV risk. Papers examined the sexual revolution in China and the experiences of indigenous people in Brazil, Australia, and New Zealand. The presentations also highlighted drug use cultures among gay men in Australian and German cities and introduced new research methodologies for the analysis of these processes and issues. The closing presentation considered the politics of HIV and their relationship to national and international processes of negative societal responses to HIV diseases. PMID:11364796

  10. PREFACE: 3rd International Conference on Manufacturing, Optimization, Industrial and Material Engineering (MOIME 2015)

    NASA Astrophysics Data System (ADS)

    Lumban Gaol, Ford; Webb, Jeff; Ding, Jun

    2015-05-01

    The 3rd International Conference on Manufacturing, Optimization, Industrial and Material Engineering (MOIME 2015) was held at the Sheraton Kuta, Bali, Indonesia, from 28 - 29 March 2015. The MOIME 2015 conference is aimed to bring together researchers, engineers and scientists in the domain of interest from around the world. MOIME 2015 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within Material Engineering, Industrial Engineering and all areas that relate to Optimization. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting Conference Program, as well as the invited and plenary speakers. This year, we received 99 papers and after rigorous review, 24 papers were accepted. The participants come from eight countries. There were four parallel sessions and two invited speakers. It is an honour to present this volume of IOP Conference Series: Materials Science and Engineering (MSE) and we deeply thank the authors for their enthusiastic and high-grade contributions. Finally, we would like to thank the conference chairmen, the members of the steering committee, the organizing committee, the organizing secretariat and the financial support from the conference sponsors that allowed the success of MOIME 2015. The Editors of the MOIME 2015 Proceedings Dr. Ford Lumban Gaol Jeff Webb, Ph.D Prof. Jun DING, Ph.D

  11. Effect of 3rd-degree gravity harmonics and Earth perturbations on lunar artificial satellite orbits

    NASA Astrophysics Data System (ADS)

    Tzirti, S.; Tsiganis, K.; Varvoglis, H.

    2010-12-01

    In a previous work we studied the effects of (I) the J 2 and C 22 terms of the lunar potential and (II) the rotation of the primary on the critical inclination orbits of artificial satellites. Here, we show that, when 3rd-degree gravity harmonics are taken into account, the long-term orbital behavior and stability are strongly affected, especially for a non-rotating central body, where chaotic or collision orbits dominate the phase space. In the rotating case these phenomena are strongly weakened and the motion is mostly regular. When the averaged effect of the Earth’s perturbation is added, chaotic regions appear again for some inclination ranges. These are more important for higher values of semi-major axes. We compute the main families of periodic orbits, which are shown to emanate from the ‘frozen eccentricity’ and ‘critical inclination’ solutions of the axisymmetric problem (‘ J 2 + J 3’). Although the geometrical properties of the orbits are not preserved, we find that the variations in e, I and g can be quite small, so that they can be of practical importance to mission planning.

  12. Measurement and correction of the 3rd order resonance in the Tevatron

    SciTech Connect

    Schmidt, F.; Alexahin, Y.; Lebedev, V.; Still, D.; Valishev, A.; /Fermilab

    2006-06-01

    At Fermilab Tevatron BPM system has been recently upgraded resulting much better accuracy of beam position measurements and improvements of data acquisition for turn-by-turn measurements. That allows one to record the beam position at each turn for 8000 turns for all BPMs (118 in each plane) with accuracy of about 10-20 {micro}m. In the last decade a harmonic analysis tool has been developed at CERN that allows relating each FFT line derived from the BPM data with a particular non-linear resonance in the machine. In fact, one can even detect the longitudinal position of the sources of these resonances. Experiments have been performed at the Tevatron in which beams have been kicked to various amplitudes to analyze the 3rd order resonance. It was possible to address this rather large resonance to some regular machine sextupoles. An alternative sextupole scheme allowed the suppression of this resonance by a good factor of 2. Lastly, the experimental data are compared with model calculations.

  13. The Power of PreK-3rd: How a Small Foundation Helped Push Washington State to the Forefront of the PreK-3rd Movement. FCD Case Study

    ERIC Educational Resources Information Center

    Nyhan, Paul

    2011-01-01

    The New School Foundation was not born from a commission, legislative mandate, research project, think tank, or even the mind of a leading education scholar. One of Washington state's pioneering PreK-3rd initiatives began as the brainchild of a wealthy Seattle businessman, Stuart Sloan, 20 years ago. The New School Foundation and its ideas were…

  14. Human APOBEC3G incorporation into murine leukemia virus particles

    SciTech Connect

    Kremer, Melanie; Schnierle, Barbara S. . E-mail: schba@pei.de

    2005-06-20

    The human APOBEC3G protein exhibits broad antiretroviral activity against a variety of retroviruses. It is packaged into viral particles and executes its antiviral function in the target cell. The packaging of APOBEC3G into different viral particles requires a mechanism that confers this promiscuity. Here, APOBEC3G incorporation into murine leukemia virus (MLV) was studied using retroviral vectors. APOBEC3G uptake did not require either its cytidine deaminase activity or the presence of a retroviral vector genome. Results from immunoprecipitation and co-localization studies of APOBEC3G with a MLV Gag-CFP (cyan fluorescent protein) fusion protein imply an interaction between both proteins. RNase A treatment did not inhibit the co-precipitation of Gag-CFP and APOBEC3G, suggesting that the interaction is RNA independent. Like human immunodeficiency virus (HIV) Gag, the MLV Gag precursor protein appears to interact with APOBEC3G, indicating that Gag contains conserved structures which are used to encapsidate APOBEC3G into different retroviral particles.

  15. 3rd hand smoking; heterogeneous oxidation of nicotine and secondary aerosol formation in the indoor environment

    NASA Astrophysics Data System (ADS)

    Petrick, Lauren; Dubowski, Yael

    2010-05-01

    Tobacco smoking is well known as a significant source of primary indoor air pollutants. However, only recently has it been recognized that the impact of Tobacco smoking may continue even after the cigarette has been extinguished (i.e., third hand smoke) due to the effect of indoor surfaces. These surfaces may affect the fate of tobacco smoke in the form of secondary reactions and pollutants, including secondary organic aerosol (SOA) formation. Fourier Transform Infrared spectrometry with Attenuated Total Reflection (FTIR-ATR) in tandem with a Scanning Mobility Particle Sizing (SMPS) system was used to monitor the ozonation of cellulose sorbed nicotine and resulting SOA formation. SOA formation began at onset of ozone introduction ([O3] = 60 ± 5 ppb) with a size distribution of dp ≤ 25 nm, and was determined to be a result of heterogeneous reaction (opposed to homogeneous). SOA yield from reacted surface nicotine was on the order of 10 %. Simultaneous to SOA monitoring, FTIR-ATR spectra showed surface changes in the nicotine film as the reaction progressed, revealing a pseudo first-order surface reaction rate of 0.0026 ± 0.0008 min-1. Identified surface oxidation products included: cotinine, myosmine, methylnicotinamide and nicotyrine. Surface reaction rate was found to be partially inhibited at high relative humidity. Given the toxicity of some of the identified products (e.g., cotinine has shown potential mutagenicity and teratogenicity) and that small particles may contribute to adverse health effects, the present study indicates that exposure to 3rd hand smoke ozonation products may pose additional health risks.

  16. Catalysis in the 3rd Dimension: How Organic Molecules May be Formed

    NASA Technical Reports Server (NTRS)

    Freund, Friedemann; DeVincenzi, D. (Technical Monitor)

    2001-01-01

    Catalysis is often little more than a word to phenomenologically describe the fact that a reaction follows a pat1 that leads to products of an unexpected kind or of unexpected yield. Low activation energy barriers for intermediates are recognized as the most likely cause why a system deviates from the thermodynamic pull towards minimizing its free energy and ends up in a metastable state. Seldom is the mechanism known. This i: particularly true for heterogeneous catalysis under hydrothermal conditions with minerals as catalysts. It is commonly assumed that catalytic action takes place across solid-fluid interfaces and that, on the atomic level, interfaces are just 2-dimensional contacts. This makes it difficult to understand, for instance, the assembly of long-chain carboxylic (fatty) acids. 3y studying single crystals that grew from a melt in the presence of H2O and CO2, we can show: (1) that numerals take up the fluid components into solid solution, (2) that some-thing happens converting them to -educedH and C, (3) that C atoms segregate into dislocations and tie C-C bonds. The products are medium-to-long chain Cn protomolecules, with some C-H attached, pre-assembled in the dislocations. Upon solvent extraction, these proto-molecules turn into carboxylic and dicarboxylic acids. This observation suggests that, in a very elementary step, catalysis under hydrothermal conditions leading to fatty acids involves the pre-assembly of Cn entities in the interface that is not 2-D but extends into the 3rd dimension, with dislocations as synthesis sites.

  17. PREFACE: 3rd International Youth Conference "Interdisciplinary Problems of Nanotechnology, Biomedicine and Nanotoxicology" (Nanobiotech 2015)

    NASA Astrophysics Data System (ADS)

    Refsnes, Magne, Prof; Gusev, Alexander, Dr; Godymchuk, Anna, Dr; Bogdan, Anna

    2015-11-01

    The 3rd International Youth Conference "Interdisciplinary Problems of Nanotechnology, Biomedicine and Nanotoxicology" (Nanobiotech2015) was held on 21-22 May 2015 in Tambov, Russia, and was jointly organized by Tambov Derzhavin State University (Russia), the Norwegian Institute of Public Health (Norway), the National University of Science and Technology MISiS (Russia), Tomsk Polytechnic University (Russia) and Tomsk State University. The conference gathered experienced and young researchers, post-docs and students, working in the fieldof nanotechnologies, nanomedicine, nano(eco)toxicology and risk assessment of nanomaterials, in order to facilitate the aggregation and sharing of interests and results for better collaboration and visibility of activity. The goal of Nanobiotech2015 was to bring researchers and practitioners together to share the latest knowledge on nanotechnology-specific risks to occupational and environmental health and assessing how to reduce these potential risks. The main objective of the conference is to identify, systematize and solve current scientific problems inthe sphere of nanobiotechnologies, nanomedicine and nanotoxicology, in order to join forces todetermine prospective areas and compose working groups of interested co-workers for carrying out interdisciplinary research projects. The topics of Nanobiotech2015 were: (1) Nanotechnologies in pharmaceutics and medicine; (2) Sources and mechanisms of nanoparticle release into the environment; (3) Ecological and biological effects of nanoparticles; (4) (Eco)toxicology of nanomaterials; (5) Methods for detection of nanoparticles in the environment and in biological objects; and (6) Physico-chemical properties of nanoparticles in the environment. We want to thank the Organizing Committee, the universities and sponsors supporting the conference,and everyone who contributed to the organization of this meeting, for their contribution towards the conference and for their contributions to these

  18. Modified SNOW 3G: Stream cipher algorithm using piecewise linear chaotic map

    NASA Astrophysics Data System (ADS)

    Wasi, Muhammad Arif Ali; Windarta, Susila

    2016-02-01

    SNOW 3G is a synchronous stream cipher developed by Thomas Johansson and Patrik Ekhdal at Lund University. In 2006, it was chosen as the main part of the second set of Universal Mobile Telecommunications System (UMTS) confidentiality and integrity algorithms [2]. In 2008, Patrik Böhm published a report entitled "Statistical Evaluation of Stream Cipher SNOW 3G". He tested the randomness properties of SNOW 3G key stream generator. Böhm using NIST statistical test suite as randomness test tool with three kinds of test, i.e. long key stream data set, short key stream data set, and initialization vector data set. The result of the report shows that from three kind of tests, only short key stream data set has not passed eight randomness tests. He state that the suggests SNOW 3G fail because there is a weakness in the initialization of the cipher. In this paper we modify SNOW 3G algorithm using piecewise linear chaotic map (PLCM) on the key initialization mode and keystream generation mode. We use the same statistical test that have been used by Böhm [5]. The experiment shows that modified SNOW 3G stream cipher algorithm has passed all the statistical test. The results prove that PLCM impact on algorithm's randomness.

  19. Test Review: C. Keith Conners "Conners 3rd Edition" Toronto, Ontario, Canada--Multi-Health Systems, 2008

    ERIC Educational Resources Information Center

    Kao, Grace S.; Thomas, Hillary M.

    2010-01-01

    "Conners 3rd Edition" is the most updated version of a series of measures for assessing attention deficit hyperactivity disorder (ADHD) and common comorbid problems/disorders in children and adolescents ranging from 6 to 18 years of age. Related problems that the test helps assess include executive dysfunction, learning problems, aggression, and…

  20. Exemplary Institute. Proceedings of the Annual Conference (3rd, Albuquerque, New Mexico, February 22-24, 1998).

    ERIC Educational Resources Information Center

    Native American Scholarship Fund, Inc., Albuquerque, NM.

    This proceedings contains presentations and workshop summaries from the 3rd Annual Exemplary Institute for educators of Native American students. Presentations include: "Quality in Learning: Romancing the Journey" (quality management at Mount Edgecumbe High School, Alaska) (Todd Bergman); "Creating a School-wide Literacy Climate" (Sig Boloz); "How…

  1. Constancy and Variability: Dialogic Literacy Events as Sites for Improvisation in Two 3rd-Grade Classrooms

    ERIC Educational Resources Information Center

    Jordan, Michelle E.; Santori, Diane

    2015-01-01

    This multisite study investigates dialogic literacy events that revolved around narrative and informational texts in two 3rd-grade classrooms. The authors offer a metaphor of musical improvisation to contemplate dialogic literacy events as part of the repertoire of teaching and learning experiences. In literacy learning, where there is much…

  2. 3rd Annual PIALA Conference Saipan--Collecting, Preserving & Sharing Information in Micronesia. Conference Proceedings. October 13-15, 1993.

    ERIC Educational Resources Information Center

    Edmundson, Margaret, Ed.

    1993-01-01

    This PIALA 1993 Proceedings contains many of the papers presented at the 3rd annual conference of the Pacific Islands Association of Libraries and Archives. This publication is the first time papers from this Micronesian regional library and archives conference have ever been published. The conference addressed various topics of interest to…

  3. Predicting 3rd Grade and 10th Grade FCAT Success for 2007-08. Research Brief. Volume 0702

    ERIC Educational Resources Information Center

    Froman, Terry; Rubiera, Vilma

    2008-01-01

    For the past few years the Florida School Code has set the Florida Comprehensive Assessment Test (FCAT) performance requirements for promotion of 3rd graders and graduation for 10 graders. Grade 3 students who do not score at level 2 or higher on the FCAT SSS Reading must be retained unless exempted for special circumstances. Grade 10 students…

  4. Predicting 3rd Grade and 10th Grade FCAT Success for 2006-07. Research Brief. Volume 0601

    ERIC Educational Resources Information Center

    Froman, Terry; Rubiera, Vilma

    2006-01-01

    For the past few years the Florida School Code has set the Florida Comprehensive Assessment Test (FCAT) performance requirements for promotion of 3rd graders and graduation for 10th graders. Grade 3 students who do not score at level 2 or higher on the FCAT SSS Reading must be retained unless exempted for special circumstances. Grade 10 students…

  5. Meeting report on the 3rd International Congress on Developmental Origins of Health and Disease (DOHaD)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Developmental Origins of Health and Disease (DOHaD) focuses on the earliest stages of human development, and provides a novel paradigm to complement other strategies for lifelong prevention of common chronic health conditions. The 3rd International Congress on DOHaD, held in 2005, retained the most ...

  6. Iowa Acceleration Scale Manual: A Guide for Whole-Grade Acceleration K-8. (3rd Edition, Manual)

    ERIC Educational Resources Information Center

    Assouline, Susan G.; Colangelo, Nicholas; Lupkowski-Shoplik, Ann; Forstadt, Leslie; Lipscomb, Jonathon

    2009-01-01

    Feedback from years of nationwide use has resulted in a 3rd Edition of this unique, systematic, and objective guide to considering and implementing academic acceleration. Developed and tested by the Belin-Blank Center at the University of Iowa, the IAS ensures that acceleration decisions are systematic, thoughtful, well reasoned, and defensible.…

  7. Visual Arts Teaching in Kindergarten through 3rd-Grade Classrooms in the UAE: Teacher Profiles, Perceptions, and Practices

    ERIC Educational Resources Information Center

    Buldu, Mehmet; Shaban, Mohamed S.

    2010-01-01

    This study portrayed a picture of kindergarten through 3rd-grade teachers who teach visual arts, their perceptions of the value of visual arts, their visual arts teaching practices, visual arts experiences provided to young learners in school, and major factors and/or influences that affect their teaching of visual arts. The sample for this study…

  8. Iron metabolism in African American women during the 2nd and 3rd trimester of a high-risk pregnancy

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Objective: To examine iron metabolism during the 2nd and 3rd trimester in African American women classified as a high-risk pregnancy. Design: Longitudinal. Setting: Large, university-based, urban Midwestern medical center. Participants: Convenience sample of 47 African American women classified a...

  9. Coexistence of 3G Repeaters with LTE Base Stations

    PubMed Central

    Yeo, Woon-Young

    2013-01-01

    Repeaters have been an attractive solution for mobile operators to upgrade their wireless networks at low cost and to extend network coverage effectively. Since the first LTE commercial deployment in 2009, many mobile operators have launched LTE networks by upgrading their 3G and legacy networks. Because all 3G frequency bands are shared with the frequency bands for LTE deployment and 3G mobile operators have an enormous number of repeaters, reusing 3G repeaters in LTE networks is definitely a practical and cost-efficient solution. However, 3G repeaters usually do not support spatial multiplexing with multiple antennas, and thus it is difficult to reuse them directly in LTE networks. In order to support spatial multiplexing of LTE, the role of 3G repeaters should be replaced with small LTE base stations or MIMO-capable repeaters. In this paper, a repeater network is proposed to reuse 3G repeaters in LTE deployment while still supporting multilayer transmission of LTE. Interestingly, the proposed network has a higher cluster throughput than an LTE network with MIMO-capable repeaters. PMID:24459420

  10. Does 3rd Age + 3rd World = 3rd Class?

    ERIC Educational Resources Information Center

    Tout, Ken

    1992-01-01

    Demographic changes, migration, and industrialization are having drastic effects on older adults in developing nations. Local programs such as Pro Vida in Colombia, supported by Help Age International, rely on the support of volunteers to improve the quality of life for elderly people. (SK)

  11. PREFACE: 3rd International Workshop on Statistical Physics and Mathematics for Complex Systems (SPMCS 2012)

    NASA Astrophysics Data System (ADS)

    Tayurskii, Dmitrii; Abe, Sumiyoshi; Alexandre Wang, Q.

    2012-11-01

    The 3rd International Workshop on Statistical Physics and Mathematics for Complex Systems (SPMCS2012) was held between 25-30 August at Kazan (Volga Region) Federal University, Kazan, Russian Federation. This workshop was jointly organized by Kazan Federal University and Institut Supérieur des Matériaux et Mécaniques Avancées (ISMANS), France. The series of SPMCS workshops was created in 2008 with the aim to be an interdisciplinary incubator for the worldwide exchange of innovative ideas and information about the latest results. The first workshop was held at ISMANS, Le Mans (France) in 2008, and the third at Huazhong Normal University, Wuhan (China) in 2010. At SPMCS2012, we wished to bring together a broad community of researchers from the different branches of the rapidly developing complexity science to discuss the fundamental theoretical challenges (geometry/topology, number theory, statistical physics, dynamical systems, etc) as well as experimental and applied aspects of many practical problems (condensed matter, disordered systems, financial markets, chemistry, biology, geoscience, etc). The program of SPMCS2012 was prepared based on three categories: (i) physical and mathematical studies (quantum mechanics, generalized nonequilibrium thermodynamics, nonlinear dynamics, condensed matter physics, nanoscience); (ii) natural complex systems (physical, geophysical, chemical and biological); (iii) social, economical, political agent systems and man-made complex systems. The conference attracted 64 participants from 10 countries. There were 10 invited lectures, 12 invited talks and 28 regular oral talks in the morning and afternoon sessions. The book of Abstracts is available from the conference website (http://www.ksu.ru/conf/spmcs2012/?id=3). A round table was also held, the topic of which was 'Recent and Anticipated Future Progress in Science of Complexity', discussing a variety of questions and opinions important for the understanding of the concept of

  12. Building monument materials during the 3rd-4rd millennium (Portugal)

    NASA Astrophysics Data System (ADS)

    Moita, Patricia; Pedro, Jorge; Boaventura, Rui; Mataloto, Rui; Maximo, Jaime; Almeida, Luís; Nogueira, Pedro

    2014-05-01

    Dolmens are the most conspicuous remains of the populations of the 4th and first half of 3rd millennia BCE. These tombs are impressive not only for their monumentality, but also because of the socioeconomic investment they represent for those Neolithic communities, namely from the Central-South of Portugal, who built them. Although dolmens have been studied for their funerary content and typologies, an interdisciplinary approach toward the geological characterization and sourcing of stones used in these constructions has not received enough attention from researchers. With MEGAGEO project a multidisciplinary group of geologist and archaeologists intends to assess the relationship between the distribution of dolmens in Central-South Portugal, their source materials, and the geological landscape. GIS will map the information gathered and will be used to analyse these relationships. The selection of the areas, with distinctive geologies (limestone vs granite), will allow to verify if human patterns of behaviour regarding the selection of megaliths are similar or different regionally. Geologically the first target area (Freixo, Alentejo) is dominated by a small intrusion of gabbro mingled/mixed within a granodioritic intrusion both related with variscan orogeny. Granodiorite exhibit several enclaves of igneous and metamorphic nature attesting the interaction between both igneous rocks as well with enclosing gneisses. Despite Alentejo region have a reduced number of outcrops the granodiorite provides rounded to tabular metric blocks. The gabbro is very coarse grained, sometimes with a cumulate texture, and their fracturing and weathering provide very fresh tabular blocks. The five studied dolmens (Quinta do Freixo #1 to #5) are implanted in a large granodioritic intrusion, around the gabbroic rocks, within an area of approximately 9km2. The medium grained granodiorite is ubiquity in all the dolmens slabs and occasionally it can be observed features of mixing and

  13. Essential surgery: key messages from Disease Control Priorities, 3rd edition.

    PubMed

    Mock, Charles N; Donkor, Peter; Gawande, Atul; Jamison, Dean T; Kruk, Margaret E; Debas, Haile T

    2015-05-30

    The World Bank will publish the nine volumes of Disease Control Priorities, 3rd edition, in 2015-16. Volume 1--Essential Surgery--identifies 44 surgical procedures as essential on the basis that they address substantial needs, are cost effective, and are feasible to implement. This report summarises and critically assesses the volume's five key findings. First, provision of essential surgical procedures would avert about 1·5 million deaths a year, or 6-7% of all avertable deaths in low-income and middle-income countries. Second, essential surgical procedures rank among the most cost effective of all health interventions. The surgical platform of the first-level hospital delivers 28 of the 44 essential procedures, making investment in this platform also highly cost effective. Third, measures to expand access to surgery, such as task sharing, have been shown to be safe and effective while countries make long-term investments in building surgical and anaesthesia workforces. Because emergency procedures constitute 23 of the 28 procedures provided at first-level hospitals, expansion of access requires that such facilities be widely geographically diffused. Fourth, substantial disparities remain in the safety of surgical care, driven by high perioperative mortality rates including anaesthesia-related deaths in low-income and middle-income countries. Feasible measures, such as WHO's Surgical Safety Checklist, have led to improvements in safety and quality. Fifth, the large burden of surgical disorders, cost-effectiveness of essential surgery, and strong public demand for surgical services suggest that universal coverage of essential surgery should be financed early on the path to universal health coverage. We point to estimates that full coverage of the component of universal coverage of essential surgery applicable to first-level hospitals would require just over US$3 billion annually of additional spending and yield a benefit-cost ratio of more than 10:1. It would

  14. ic-cmtp3: 3rd International Conference on Competitive Materials and Technology Processes

    NASA Astrophysics Data System (ADS)

    2016-04-01

    Competitiveness is one of the most important factors in our lives and it plays a key role in the efficiency both of organizations and societies. The more scientifically advanced and prepared organizations develop more competitive materials with better physical, chemical, and biological properties, and the leading companies apply more competitive equipment and technological processes. The aims of the 3rd International Conference on Competitive Materials and Technology Processes (ic-cmtp3), and the 1st International Symposium on Innovative Carbons and Carbon Based Materials (is-icbm1) and the 1st International Symposium on Innovative Construction Materials (is-icm1) organized alongside are the following: —Promote new methods and results of scientific research in the fields of material, biological, environmental and technological sciences; —Exchange information between the theoretical and applied sciences as well as technical and technological implementations; —Promote communication and collaboration between the scientists, researchers and engineers of different nations, countries and continents. Among the major fields of interest are advanced and innovative materials with competitive characteristics, including mechanical, physical, chemical, biological, medical and thermal, properties and extreme dynamic strength. Their crystalline, nano - and micro-structures, phase transformations as well as details of their technological processes, tests and measurements are also in the focus of the ic-cmtp3 conference and the is-scbm1 and is-icm1 symposia. Multidisciplinary applications of material science and the technological problems encountered in sectors like ceramics, glasses, thin films, aerospace, automotive and marine industries, electronics, energy, construction materials, medicine, biosciences and environmental sciences are of particular interest. In accordance with the program of the ic-cmtp3 conference and is-icbm1 and is-icm1 symposia we have received more

  15. PREFACE: 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"

    NASA Astrophysics Data System (ADS)

    Yamada, Taiichi; Kanada-En'yo, Yoshiko

    2014-12-01

    The 3rd International Workshop on "State of the Art in Nuclear Cluster Physics"(SOTANCP3) was held at KGU Kannai Media Center, Kanto Gakuin University, Yokohama, Japan, from May 26 to 30, 2014. Yokohama is the second largest city in Japan, about 25 km southeast of Tokyo. The first workshop of the series was held in Strasbourg, France, in 2008 and the second one was in Brussels, Belgium, in 2010. The purpose of SOTANCP3 was to discuss the present status and future perspectives of the nuclear cluster physics. The following nine topics were selected in order to cover most of the scientific programme and highlight an area where new ideas have emerged over recent years: (1) Cluster structures and many-body correlations in stable and unstable nuclei (2) Clustering aspects of nuclear reactions and resonances (3) Alpha condensates and analogy with condensed matter approaches (4) Role of tensor force in cluster physics and ab initio approaches (5) Clustering in hypernuclei (6) Nuclear fission, superheavy nuclei, and cluster decay (7) Cluster physics and nuclear astrophysics (8) Clustering in nuclear matter and neutron stars (9) Clustering in hadron and atomic physics There were 122 participants, including 53 from 17 foreign countries. In addition to invited talks, we had many talks selected from contributed papers. There were plenary, parallel, and poster sessions. Poster contributions were also presented as four-minute talks in parallel sessions. This proceedings contains the papers presented in invited and selected talks together with those presented in poster sessions. We would like to express our gratitude to the members of the International Advisory Committee and those of the Organizing Committee for their efforts which made this workshop successful. In particular we would like to present our great thanks to Drs. Y. Funaki, W. Horiuchi, N. Itagaki, M. Kimura, T. Myo, and T. Yoshida. We would like also to thank the following organizations for their sponsors: RCNP

  16. EDITORIAL: Photonica 2011: 3rd International School and Conference on Photonics Photonica 2011: 3rd International School and Conference on Photonics

    NASA Astrophysics Data System (ADS)

    Petrović, Jovana; Stepić, Milutin; Hadžievski, Ljupčo

    2012-04-01

    Photonics is a rapidly growing discipline of physics that investigates properties of light and its interaction with matter and develops devices based on these properties. Due to both the fundamental and applied nature of photonics research, it pervades many branches of modern technology: quantum mechanics, material science, electronics, telecommunications, biology, medicine, material processing, etc. The borders between these subjects are being erased, generating new research areas such as silicon photonics, biophotonics and quantum photonics. Diverse branches of photonics are united in a common effort to further miniaturize photonic devices, integrate them with existing technologies and develop new technologies. The International School and Conference on Photonics—Photonica—is a biennial forum for the education of young scientists, exchanging new knowledge and ideas, and fostering collaboration between scientists working in photonic science and technology. Conference topics cover a broad range of research activities in optical materials, metamaterials and plasmonics, nonlinear optics, lasers, laser spectroscopy, biophotonics, optoelectronics, optocommunications, photonic crystals, holography, quantum optics and related topics in atomic physics. The aim of the organizers is to provide a platform for discussing new developments, concepts and future trends of various disciplines of photonics by bringing together researchers from academia, government and industrial laboratories. The educational element of Photonica—a series of tutorials and keynote talks—enables students and young researchers to better understand the fundamentals and their use on a route to applications, and informs both young and experienced scientists of new directions of research. The introductory lectures that are directly related to the state-of-the-art are followed by presentations and discussions on recent results during oral and vibrant poster presentations. This Topical Issue is

  17. EIF3G is associated with narcolepsy across ethnicities.

    PubMed

    Holm, Anja; Lin, Ling; Faraco, Juliette; Mostafavi, Sara; Battle, Alexis; Zhu, Xiaowei; Levinson, Douglas F; Han, Fang; Gammeltoft, Steen; Jennum, Poul; Mignot, Emmanuel; Kornum, Birgitte R

    2015-11-01

    Type 1 narcolepsy, an autoimmune disease affecting hypocretin (orexin) neurons, is strongly associated with HLA-DQB1*06:02. Among polymorphisms associated with the disease is single-nucleotide polymorphism rs2305795 (c.*638G>A) located within the P2RY11 gene. P2RY11 is in a region of synteny conserved in mammals and zebrafish containing PPAN, EIF3G and DNMT1 (DNA methyltransferase 1). As mutations in DNMT1 cause a rare dominant form of narcolepsy in association with deafness, cerebellar ataxia and dementia, we questioned whether the association with P2RY11 in sporadic narcolepsy could be secondary to linkage disequilibrium with DNMT1. Based on genome-wide association data from two cohorts of European and Chinese ancestry, we found that the narcolepsy association signal drops sharply between P2RY11/EIF3G and DNMT1, suggesting that the association with narcolepsy does not extend into the DNMT1 gene region. Interestingly, using transethnic mapping, we identified a novel single-nucleotide polymorphism rs3826784 (c.596-260A>G) in the EIF3G gene also associated with narcolepsy. The disease-associated allele increases EIF3G mRNA expression. EIF3G is located in the narcolepsy risk locus and EIF3G expression correlates with PPAN and P2RY11 expression. This suggests shared regulatory mechanisms that might be affected by the polymorphism and are of relevance to narcolepsy. PMID:25669430

  18. Different Modes of Retrovirus Restriction by Human APOBEC3A and APOBEC3G In Vivo

    PubMed Central

    Stavrou, Spyridon; Crawford, Daniel; Blouch, Kristin; Browne, Edward P.; Kohli, Rahul M.; Ross, Susan R.

    2014-01-01

    The apolipoprotein B editing complex 3 (A3) cytidine deaminases are among the most highly evolutionarily selected retroviral restriction factors, both in terms of gene copy number and sequence diversity. Primate genomes encode seven A3 genes, and while A3F and 3G are widely recognized as important in the restriction of HIV, the role of the other genes, particularly A3A, is not as clear. Indeed, since human cells can express multiple A3 genes, and because of the lack of an experimentally tractable model, it is difficult to dissect the individual contribution of each gene to virus restriction in vivo. To overcome this problem, we generated human A3A and A3G transgenic mice on a mouse A3 knockout background. Using these mice, we demonstrate that both A3A and A3G restrict infection by murine retroviruses but by different mechanisms: A3G was packaged into virions and caused extensive deamination of the retrovirus genomes while A3A was not packaged and instead restricted infection when expressed in target cells. Additionally, we show that a murine leukemia virus engineered to express HIV Vif overcame the A3G-mediated restriction, thereby creating a novel model for studying the interaction between these proteins. We have thus developed an in vivo system for understanding how human A3 proteins use different modes of restriction, as well as a means for testing therapies that disrupt HIV Vif-A3G interactions. PMID:24851906

  19. A global drought climatology for the 3rd edition of the World Atlas of Desertification (WAD)

    NASA Astrophysics Data System (ADS)

    Spinoni, Jonathan; Carrao, Hugo; Naumann, Gustavo; Antofie, Tiberiu; Barbosa, Paulo; Vogt, Jürgen

    2013-04-01

    A new version of the World Atlas of Desertification (WAD) is being compiled in the framework of cooperation between the Joint Research Centre (JRC) of the European Commission and the United Nations Environment Programme (UNEP). This initiative aims at mapping the global land degradation and desertification, as well as introducing the reader with complex interactions of geo-physical, socio-economic, and political aspects that affect the environmental sustainability. Recurrent extreme events resulting from climate change, such as more severe droughts, combined with non-adapted land use practices can affect the resilience of ecosystems tipping them into a less productive state. Thus, to describe the effects of climatological hazards on land degradation and desertification processes, we computed a World drought climatology that will be part of the 3rd edition of the WAD and will replace and update to 2010 the results presented in the 2nd edition in 1997. This paper presents the methodology used to compute three parameters included in the WAD drought climatology, i.e. drought frequency, intensity and duration, and discusses their spatio-temporal patterns both at global and continental scales. Because drought is mainly driven and triggered by a rainfall deficit, we chose the Standardized Precipitation Index (SPI) as the drought indicator to estimate our climatological parameters. The SPI is a statistical precipitation-based drought indicator widely used in drought-related studies. We calculated the SPI on three different accumulation periods: 3 months (SPI-3), 6 months (SPI-6), and 12 months (SPI-12), in order to take into account meteorological, agricultural, and hydrological drought-related features. Each quantity has been calculated on a monthly basis using the baseline period between January 1951 and December 2010. As data input, we used the Full Data Reanalysis Version 6.0 (0.5˚x0.5˚) of gridded monthly precipitation provided by the Global Precipitation

  20. PREFACE: 3rd Workshop on Theory, Modelling and Computational Methods for Semiconductors (TMCSIII)

    NASA Astrophysics Data System (ADS)

    Califano, Marco; Migliorato, Max; Probert, Matt

    2012-05-01

    These conference proceedings contain the written papers of the contributions presented at the 3rd International Conference on Theory, Modelling and Computational Methods for Semiconductor materials and nanostructures. The conference was held at the School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK on 18-20 January 2012. The previous conferences in this series took place in 2010 at St William's College, York and in 2008 at the University of Manchester, UK. The development of high-speed computer architectures is finally allowing the routine use of accurate methods for calculating the structural, thermodynamic, vibrational, optical and electronic properties of semiconductors and their hetero- and nano-structures. The scope of this conference embraces modelling, theory and the use of sophisticated computational tools in semiconductor science and technology, where there is substantial potential for time-saving in R&D. Theoretical approaches represented in this meeting included: Density Functional Theory, Tight Binding, Semiempirical Pseudopotential Methods, Effective Mass Models, Empirical Potential Methods and Multiscale Approaches. Topics included, but were not limited to: Optical and Transport Properties of Quantum Nanostructures including Colloids and Nanotubes, Plasmonics, Magnetic Semiconductors, Graphene, Lasers, Photonic Structures, Photovoltaic and Electronic Devices. This workshop ran for three days, with the objective of bringing together UK and international leading experts in the theoretical modelling of Group IV, III-V and II-VI semiconductors, as well as students, postdocs and early-career researchers. The first day focused on providing an introduction and overview of this vast field, aimed particularly at students, with several lectures given by recognised experts in various theoretical approaches. The following two days showcased some of the best theoretical research carried out in the UK in this field, with several

  1. FOREWORD: 3rd International Workshop on New Computational Methods for Inverse Problems (NCMIP 2013)

    NASA Astrophysics Data System (ADS)

    Blanc-Féraud, Laure; Joubert, Pierre-Yves

    2013-10-01

    Conference logo This volume of Journal of Physics: Conference Series is dedicated to the scientific contributions presented during the 3rd International Workshop on New Computational Methods for Inverse Problems, NCMIP 2013 (http://www.farman.ens-cachan.fr/NCMIP_2013.html). This workshop took place at Ecole Normale Supérieure de Cachan, in Cachan, France, on 22 May 2013, at the initiative of Institut Farman. The prior editions of NCMIP also took place in Cachan, France, firstly within the scope of the ValueTools Conference, in May 2011 (http://www.ncmip.org/2011/), and secondly at the initiative of Institut Farman, in May 2012 (http://www.farman.ens-cachan.fr/NCMIP_2012.html). The NCMIP Workshop focused on recent advances in the resolution of inverse problems. Indeed inverse problems appear in numerous scientific areas such as geophysics, biological and medical imaging, material and structure characterization, electrical, mechanical and civil engineering, and finances. The resolution of inverse problems consists of estimating the parameters of the observed system or structure from data collected by an instrumental sensing or imaging device. Its success firstly requires the collection of relevant observation data. It also requires accurate models describing the physical interactions between the instrumental device and the observed system, as well as the intrinsic properties of the solution itself. Finally, it requires the design of robust, accurate and efficient inversion algorithms. Advanced sensor arrays and imaging devices provide high rate and high volume data; in this context, the efficient resolution of the inverse problem requires the joint development of new models and inversion methods, taking computational and implementation aspects into account. During this one-day workshop, researchers had the opportunity to bring to light and share new techniques and results in the field of inverse problems. The topics of the workshop were: algorithms and computational

  2. Mechanical design and engineering of the 3.9 GHZ, 3rd harmonic SRF system at Fermilab

    SciTech Connect

    Don Mitchell et al.

    2004-08-05

    The mechanical development of the 3.9 GHz, 3rd Harmonic SRF System is summarized to include: the development of a full scale copper prototype cavity structure; the design of the niobium 3 cell and niobium 9 cell structures; the design of the helium vessel and cryostat; the HOM coupler design; and a preliminary look at the main coupler design. The manufacturing processes for forming, rolling, and e-beam welding the HOM coupler, cavity cells, and end tubes are also described. Due to the exotic materials and manufacturing processes used in this type of device, a cost estimate for the material and fabrication is provided. The 3rd harmonic design is organized via a web-based data management approach.

  3. Differential contribution of specific working memory components to mathematics achievement in 2nd and 3rd graders.

    PubMed

    Meyer, M L; Salimpoor, V N; Wu, S S; Geary, D C; Menon, V

    2010-04-01

    The contribution of the three core components of working memory (WM) to the development of mathematical skills in young children is poorly understood. The relation between specific WM components and Numerical Operations, which emphasize computation and fact retrieval, and Mathematical Reasoning, which emphasizes verbal problem solving abilities in 48 2nd and 50 3rd graders was assessed using standardized WM and mathematical achievement measures. For 2nd graders, the central executive and phonological components predicted Mathematical Reasoning skills; whereas the visuo-spatial component predicted both Mathematical Reasoning and Numerical Operations skills in 3rd graders. This pattern suggests that the central executive and phonological loop facilitate performance during early stages of mathematical learning whereas visuo-spatial representations play an increasingly important role during later stages. We propose that these changes reflect a shift from prefrontal to parietal cortical functions during mathematical skill acquisition. Implications for learning and individual differences are discussed. PMID:21660238

  4. Knowledge and institutional requirements to promote land degradation neutrality in drylands - An analysis of the outcomes of the 3rd UNCCD scientific conference

    NASA Astrophysics Data System (ADS)

    Akhtar-Schuster, Mariam; Safriel, Uriel; Abraham, Elena; de Vente, Joris; Essahli, Wafa; Escadafal, Richard; Stringer, Lindsay

    2015-04-01

    Achieving land degradation neutrality (LDN) through sustainable land management (SLM) targets the maintenance or restoration of the productivity of land, and therefore has to include decision-makers, knowledge generators and knowledge holders at the different relevant geographic scales. In order to enhance the implementation of the Convention, the Conference of the Parties (COP) of the United Nations Convention to Combat Desertification therefore decided that each future session of its Committee on Science and Technology (CST) would be organized in a predominantly scientific and technical conference-style format. This contribution will outline the major outcomes of UNCCD's 3rd scientific conference that will be held in Cancún, Mexico, from 9 to 12 March 2015, on addressing desertification, land degradation and drought issues (DLDD) for poverty reduction and sustainable development. The conference follows an exceptional new round table conference format that will allow the various stakeholders to discuss scientific as well as the contribution of traditional knowledge and practices in combating land degradation. This format should provide two-way communication and enable deeper insight into the availability and contribution of all forms of knowledge for achieving LDN through the assessment of: • the vulnerability of lands to DLDD and climate change and the adaptive capacities of socio-ecosystems; • best examples of adapted, knowledge-based practices and technologies; • monitoring and assessment methods to evaluate the effectiveness of adaptation practices and technologies. The outcomes of UNCCD's 3rd scientific conference will serve as a basis for discussing: • contributions of science to diagnose the status of land; • research gaps that need to be addressed to achieve LDN for poverty reduction; • additional institutional requirements to optimally bridge knowledge generation, knowledge maintenance and knowledge implementation at the science

  5. The effect of surgical technique on lingual nerve damage during lower 3rd molar removal by dental students.

    PubMed

    Robinson, P P; Loescher, A R; Smith, K G

    1999-05-01

    We have previously shown that avoidance of lingual flap retraction with a Howarth periosteal elevator during lower 3rd molar removal, reduces the incidence of lingual nerve damage. In that study, the surgery was undertaken by qualified staff and we have now assessed the effect of revising the method taught to our junior undergraduate dental students. We evaluated the outcome of surgery undertaken by 2 consecutive years of students, each group being taught 1 of the 2 methods. A total of 200 patients requiring lower 3rd molar removal under local anaesthesia were included in the study. In year 1, the surgery included elevation of a lingual flap and insertion of a Howarth elevator adjacent to the lingual plate; in year 2 this part of the procedure was avoided by using a purely buccal approach. There were no significant differences between the levels of tooth eruption and types of impaction of the teeth removed in each year. Lingual sensory disturbance occurred in 3 patients in the 'flap' group (3.3%) and in 1 patient (0.9%) in the 'no flap' group. As this incidence is not significantly different in the 2 groups (P < 0.4), we conclude that avoidance of lingual retraction by students undertaking lower 3rd molar removal does not appear to place the lingual nerve at greater risk. In view of the results of our previous study, we therefore advocate this method for use in undergraduate dental education. PMID:10530161

  6. Macroscale and Microscale Organic Experiments, 3rd Edition (by Kenneth L. Williamson)

    NASA Astrophysics Data System (ADS)

    Keeffe, Reviewed By James

    1999-11-01

    suggested semiempirical computations. Other new texts, for example that by Pavia et al. (3rd ed., 1999), take computation even further. New features in the third edition include reduction of the macroscale experimental quantities to amounts compatible with 14/20 standard-taper glassware. Additionally, there are some useful and characteristically clever equipment adaptations for microfiltration and gas phase IR spectra, a few new or updated experiments, replacement of all IR spectra by Fourier transform spectra, and routine use of 250-MHz 1H NMR spectra. Two-dimensional NMR spectroscopy is briefly discussed but not further encountered. One new feature which looks promising is called "Surfing the Web". Pertinent Web site addresses dot the book, but it would be useful if these were indexed as a group. The brief but up-to-date chapter on searching the literature includes addresses and some advice on accessing commercial databases. Regarding the lab course itself, two useful addresses are http://ull.chemistry.uakron.edu/organic_lab/ and Williamson's own site (under construction as I write), http://www.mtholyoke.edu/courses/kwilliam/microscale.shtml, where pictures of techniques and other support information will interest teachers and students alike. Williamson has always been responsive to users of his texts, and will probably be quick to incorporate new information and improved techniques at this site. There are a few areas where improvement can still be made. The chapter on IR spectroscopy, although revised, does not contain an extensive, conventional table of characteristic group frequencies. All our instructors supplement the text with standard tables. We also find the section on organic qualitative analysis to be limited and mildly difficult to use. Students must do a lot of page turning, back and forth, to find some of the tests and recipes needed. At SFSU more than half of our second-semester lab is given over to organic qual, and no single lab text except that of Pasto

  7. FOREWORD: 3rd International Workshop on New Computational Methods for Inverse Problems (NCMIP 2013)

    NASA Astrophysics Data System (ADS)

    Blanc-Féraud, Laure; Joubert, Pierre-Yves

    2013-10-01

    Conference logo This volume of Journal of Physics: Conference Series is dedicated to the scientific contributions presented during the 3rd International Workshop on New Computational Methods for Inverse Problems, NCMIP 2013 (http://www.farman.ens-cachan.fr/NCMIP_2013.html). This workshop took place at Ecole Normale Supérieure de Cachan, in Cachan, France, on 22 May 2013, at the initiative of Institut Farman. The prior editions of NCMIP also took place in Cachan, France, firstly within the scope of the ValueTools Conference, in May 2011 (http://www.ncmip.org/2011/), and secondly at the initiative of Institut Farman, in May 2012 (http://www.farman.ens-cachan.fr/NCMIP_2012.html). The NCMIP Workshop focused on recent advances in the resolution of inverse problems. Indeed inverse problems appear in numerous scientific areas such as geophysics, biological and medical imaging, material and structure characterization, electrical, mechanical and civil engineering, and finances. The resolution of inverse problems consists of estimating the parameters of the observed system or structure from data collected by an instrumental sensing or imaging device. Its success firstly requires the collection of relevant observation data. It also requires accurate models describing the physical interactions between the instrumental device and the observed system, as well as the intrinsic properties of the solution itself. Finally, it requires the design of robust, accurate and efficient inversion algorithms. Advanced sensor arrays and imaging devices provide high rate and high volume data; in this context, the efficient resolution of the inverse problem requires the joint development of new models and inversion methods, taking computational and implementation aspects into account. During this one-day workshop, researchers had the opportunity to bring to light and share new techniques and results in the field of inverse problems. The topics of the workshop were: algorithms and computational

  8. Research at the CEA in the field of safety in 2nd and 3rd generation light water reactors

    NASA Astrophysics Data System (ADS)

    Billot, Philippe

    2012-05-01

    The research programs at the CEA in the field of safety in nuclear reactors are carried out in a framework of international partnerships. Their purpose is to develop studies on: The methods allowing for the determination of earthquake hazards and their consequences; The behaviour of fuel in an accident situation; The comprehension of deflagration and detonation phenomena of hydrogen and the search for effective prevention methods involving an explosion risk; The cooling of corium in order to stop its progression in and outside the vessel thereby reducing the risk of perforating the basemat; The behaviour of the different fission product families according to their volatility for the UO2 and MOX fuels.

  9. What is waveform library? Advances in EPG science made possible by the 3rd generation AC-DC universal monitor

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Until recently, most Electrical Penetration Graph (EPG) studies have emphasized small-bodied sternorrhynchans, auchenorrhynchans, and thrips. EPG holds the potential to significantly improve research on a wider array of species, such as large heteropterans and blood-sucking vectors of medical/veteri...

  10. Improved method for recovery of organic solids from diluted swine manure in 3rd generation treatment system

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Solid-liquid separation of the raw manure increases the capacity of decision making and opportunities for treatment. The high-rate separation up-front using flocculants allows recovery of most of the organic compounds, which can be used for manufacture of high-quality compost materials. However, t...

  11. Project DEEP STEAM 2nd and 3rd quarter reports, April 1-September 30, 1981

    SciTech Connect

    Moreno, J.B.; Aeschliman, D.P.; Clay, R.G.; Lee, D.O.; Marshall, B.W.; Muir, J.F.

    1982-03-01

    The objective of Project DEEP STEAM is to develop the technology required to economically produce heavy oil from deep reservoirs. The tasks included in this project are development of thermally efficient delivery systems and downhole steam-generation systems. During the period April 1-September 30, 1981, activity was completed on the development of a low-pressure-combustion, indirect-contact downhole generator (Rocketdyne), and effort continued on two high-pressure, direct-contact designs (Foster-Miller Associates, Sandia National Laboratories). Field testing of the Sandia design began in the Wilmington Field at Long Beach, California. This was the first test of a high-pressure, direct-contact downhole steam generator in a deep well. Development of a second Sandia design, using pure oxygen as the oxidizer, was initiated. Progress continued on the Min-Stress II packer concept at L'Garde, Inc., and on the extruded metal packer at Foster-Miller. A new insulant test series was begun at the Tacoma test tower. The instrumented bare-string steam injection test in Canada, initiated in cooperation with Husky Oil in the last report period, was successfully completed in early May. A redesigned test program to allow simultaneous testing of several different insulated tubulars is scheduled for October 1981.

  12. R&D on wireless broadband communication systems: new generation ubiquitous mobile network

    NASA Astrophysics Data System (ADS)

    Ogawa, Hiroyo

    2007-09-01

    R&D on new generation mobile network has attracted a growing interest over the world on the background of rapid market growth for 2nd and 3rd - generation cellular networks and wireless LANs/MANs. The National Institute of Information and Communications Technology (NICT) has been carried out the New Generation Mobile Network Project from April 2002 to March 2006, and has developed fundamental technologies to enable seamless and secure integration of various wireless access networks such as existing cellular networks, wireless LANs, home networks, intelligent transport systems (ITS), the Beyond-3G (B3G) cellular and other wireless access systems. From April 2006, Ubiquitous Mobile Network project focused on cognitive radio technology and integrated seamless networking technology was started. This paper overviews the achievement and the future plan of these projects.

  13. Influence of solar eclipse of November 3rd, 2013 on the total ozone column over Badajoz, Spain

    NASA Astrophysics Data System (ADS)

    Mateos, D.; Antón, M.; Vaquero, J. M.

    2014-05-01

    The hybrid eclipse of November 3rd, 2013 was observed as partial with a magnitude equal to 0.126 from Badajoz (38° 53‧ N, 6° 58‧ W). The evolution of the total ozone column (TOC) values for 4 h was monitored using a Solar Light Microtops-II manual sun-photometer. Before the eclipse, TOC remained invariable ~280 Dobson Units (DU) for one hour and a half. Once the eclipse was started, a clear decrease in TOC occurred. After the eclipse maximum (with TOC=273 DU), a rapid TOC recovery was observed. When the eclipse was over, TOC came back to values ~280 DU.

  14. Quantitative metabolic profiles of 2nd and 3rd trimester human amniotic fluid using 1H HR-MAS spectroscopy

    PubMed Central

    Cohn, Brad R.; Zhao, Shoujun; Kornak, John; Zhang, Vickie Y.; Iman, Rahwa; Kurhanewicz, John; Vahidi, Kiarash; Yu, Jingwei; Caughey, Aaron B.; Swanson, Mark G.

    2016-01-01

    Object To establish and compare normative metabolite concentrations in 2nd and 3rd trimester human amniotic fluid samples in an effort to reveal metabolic biomarkers of fetal health and development. Materials and methods Twenty-one metabolite concentrations were compared between 2nd (15–27 weeks gestation, N = 23) and 3rd (29–39 weeks gestation, N = 27) trimester amniotic fluid samples using 1H high resolution magic angle spinning (HR-MAS) spectroscopy. Data were acquired using the electronic reference to access in vivo concentrations method and quantified using a modified semi-parametric quantum estimation algorithm modified for high-resolution ex vivo data. Results Sixteen of 21 metabolite concentrations differed significantly between 2nd and 3rd trimester groups. Betaine (0.00846±0.00206 mmol/kg vs. 0.0133±0.0058 mmol/kg, P <0.002) and creatinine (0.0124±0.0058 mmol/kg vs. 0.247±0.011 mmol/kg, P <0.001) concentrations increased significantly, while glucose (5.96±1.66 mmol/kg vs. 2.41±1.69 mmol/kg, P <0.001), citrate (0.740±0.217 mmol/kg vs. 0.399±0.137 mmol/kg, P <0.001), pyruvate (0.0659±0.0103 mmol/kg vs. 0.0299±0.286 mmol/kg, P <0.001), and numerous amino acid (e.g. alanine, glutamate, isoleucine, leucine, lysine, and valine) concentrations decreased significantly with advancing gestation. A stepwise multiple linear regression model applied to 50 samples showed that gestational age can be accurately predicted using combinations of alanine, glucose and creatinine concentrations. Conclusion These results provide key normative data for 2nd and 3rd trimester amniotic fluid metabolite concentrations and provide the foundation for future development of magnetic resonance spectroscopy (MRS) biomarkers to evaluate fetal health and development. PMID:19779747

  15. Mathematical model of the SH-3G helicopter

    NASA Technical Reports Server (NTRS)

    Phillips, J. D.

    1982-01-01

    A mathematical model of the Sikorsky SH-3G helicopter based on classical nonlinear, quasi-steady rotor theory was developed. The model was validated statically and dynamically by comparison with Navy flight-test data. The model incorporates ad hoc revisions which address the ideal assumptions of classical rotor theory and improve the static trim characteristics to provide a more realistic simulation, while retaining the simplicity of the classical model.

  16. Proceedings - 3rd joint SPE/DOE symposium on enhanced oil recovery

    SciTech Connect

    Not Available

    1982-01-01

    This conference proceedings contains 53 papers. Topics covered include: carbon dioxide flooding; high solubilization of brine and oil recovery; seismic imaging; monitoring method for carbon dioxide flooding; LPG flood evaluation; tertiary oil recovery; chemical enhancement of oil production; in-situ combustion; measuring steam quality; downhole steam generator; oxygen combustion process for heavy oil recovery; fracture-assisted steam flood; polymers for enhanced oil recovery; sealing of linear and pattern chemical floods; interfacial light scattering in microemulsion; and well injection. All papers are abstracted separately.

  17. 1993 Aerospace Avionic Systems Division Conference, 3rd, Denver, CO, Apr. 22, 1993, Proceedings

    NASA Astrophysics Data System (ADS)

    Topics addressed include a single-supply monolithic, MIL-STD-1553 transreceiver implemented in BiCMOS wafer fabrication technology, a development methodology for contemporary avionics systems, MIL-STD-1553 remote terminal design using ASIC megacell technology, a modular electrooptic bus coupler, experiences in validating MIL-STD-1553 remote terminals, and the STANAG 3910 data bus for the next generation of European avionics systems. Attention is also given to JIAWG compatible development boards for the i960, high-speed databus evaluation, the space avionics architecture standard tailored to the common lunar lander conceptual design, and 1553 RT mechanizations for data sample consistency and multimessage transfers.

  18. Internet roaming: a WLAN/3G integration system for enterprises

    NASA Astrophysics Data System (ADS)

    Luo, Hui; Jiang, Zhimei; Kim, Byoung J.; Shankar, Narendra K.; Henry, Paul

    2002-08-01

    This paper proposes an enterprise-oriented WLAN/3G network integration solution, called the Internet Roaming system. Differing from other operator-oriented WLAN/3G network integration solutions, the Internet Roaming system is a practical IP-based corporate network architecture that provides seamless internetworking across office WLAN, home WLAN, public WLAN, and 2.5G/3G cellular network for corporate wireless data users. An Internet Roaming system may have four building blocks. They are IRC (Internet Roaming Client), SMG (secure mobility gateway), SIA (Secure IP Access) gateway, and VSA (virtual single account) server. The IRC is a special client tool (software or hardware) installed on a wireless data device. It provides a secure mobile IP connection from the wireless data device to the corporate network transparent to the operating system of the wireless data devices. The SMG is a mobile IPsec gateway installed on the corporate core network facing the Internet. It works with the IRC to maintain a secure mobile IP connection when the wireless data device is connected on the Internet through a home WLAN, a public WLAN, or a cellular network. The SIA server is a special IPsec gateway installed on the corporate intranet where office WLAN is installed. It works with the IRC to assure the security of office WLAN while improving the routing efficiency for users computers. The VSA server manages the IRC, SMG, and SIA servers.

  19. A novel mutation in Prph2, a gene regulated by Nr2e3, causes retinal degeneration and outer segment defects similar to Nr2e3rd7/rd7 retinas

    PubMed Central

    Nystuen, Arne M.; Sachs, Andrew J.; Yuan, Yang; Heuermann, Laura; Haider, Neena B.

    2014-01-01

    The nmf193 mutant was generated by a large-scale ENU mutagenesis screen and originally described as having a dominantly inherited phenotype characterized by fundus abnormalities. We determined that nmf193 mice exhibit outer segment defects and progressive retinal degeneration. Clinical examination revealed retinal spotting apparent at 6 weeks of age. Histological analysis of homozygous mutant mice at 6 weeks indicated an absence of outer segments (OS) and a 50% reduction of photoreceptor cells which progressed to complete loss of photoreceptors by 10 months. Mice heterozygous for the nmf193 mutation had a less severe phenotype of shortened outer segments at 2 months with progressive loss of photoreceptor cells to 50% by 10 months. A positional cloning approach using a DNA pooling strategy was performed to identify the causative mutation in nmf193 mice. The nmf193 mutation linked to chromosome 17 and fine mapped to an interval containing the peripherin/rds (Prph2) gene. Mutation analysis identified a single base change in Prph2 that causes aberrant splicing between exon 1 and 2. Interestingly, a comparative histological analysis demonstrated that Prph2nmf193/+ mutants have similar photoreceptor degeneration to that of Nr2e3rd7/rd7. We show that Prph2 mRNA and protein levels are reduced in the Nr2e3rd7/rd7 mutant compared to control littermates. Further, chromatin immunoprecipitation analysis shows that Prph2 is a direct target of NR2E3. In addition, the down-regulation of Prph2 gene expression is similar in both the Nr2e3rd7/rd7 and Prph2nmf193/+ mutants suggesting that the reduction of Prph2 may contribute to the degenerative pathology seen in Nr2e3rd7/rd7. PMID:18763016

  20. Anticipatory grip force between 1 and 3g

    NASA Astrophysics Data System (ADS)

    White, Olivier; Van Loon, ing.. Jack J. W. A.; Thonnard, Jean-Louis; Hermsdorfer, Joachim; Lefevre, Philippe

    One remarkable capacity of utilizing common tools appropriately as soon as we grasp them relies on the ability to determine in advance the grip force (GF) required to handle them in relation to their mechanical properties and the surrounding environment. This anticipatory strategy avoids the uncompressible delays in the feedback system. The predictive control of GF is made possible because the nervous system can learn, store and then select the internal representations of the dynamics of innumerable objects, known as internal models. Beside this flexibility, the nervous system's ability to learn different task dynamics is often limited in classical robotic experiments The environment itself can be profoundly modified in altered gravity or centrifugation. The few studies that investigated motor adaptation in such contexts did not consider the interaction between gravitational phases and even less the transitions across environments. Here, we tested subject's abilities to adapt to levels of gravitational fields generated by a human centrifuge. In Experiment 1, seven subjects performed 4 lifting trials in each gravitational phase (1 to 2.5g and then 2.5 to 1g by steps of 0.5g) with a 0.12 kg instrumented object. In Experiment 2, six subjects performed vertical oscillations of the object during transitions between 1 and 3g (0.5g steps, ascending and descending phases, profile repeated twice). We continuously measured GF, load force (LF) and ambient gravity. We hypothesized that participants were able to predictively adjust GF to the new environment. In Experiment 1, participants adjusted their GF proportionally to gravity and decreased GF across trials within a given gravitational environment. Preload phases decreased over time from 300ms to 50ms irrespective of gravity. We quantified the abilities of participants to switch across environments by subtracting GF recorded in the last trial in the current gravity level from GF during the first trial in the new environment

  1. Analysis and design of a 3rd order velocity-controlled closed-loop for MEMS vibratory gyroscopes.

    PubMed

    Wu, Huan-ming; Yang, Hai-gang; Yin, Tao; Jiao, Ji-wei

    2013-01-01

    The time-average method currently available is limited to analyzing the specific performance of the automatic gain control-proportional and integral (AGC-PI) based velocity-controlled closed-loop in a micro-electro-mechanical systems (MEMS) vibratory gyroscope, since it is hard to solve nonlinear functions in the time domain when the control loop reaches to 3rd order. In this paper, we propose a linearization design approach to overcome this limitation by establishing a 3rd order linear model of the control loop and transferring the analysis to the frequency domain. Order reduction is applied on the built linear model's transfer function by constructing a zero-pole doublet, and therefore mathematical expression of each control loop's performance specification is obtained. Then an optimization methodology is summarized, which reveals that a robust, stable and swift control loop can be achieved by carefully selecting the system parameters following a priority order. Closed-loop drive circuits are designed and implemented using 0.35 μm complementary metal oxide semiconductor (CMOS) process, and experiments carried out on a gyroscope prototype verify the optimization methodology that an optimized stability of the control loop can be achieved by constructing the zero-pole doublet, and disturbance rejection capability (D.R.C) of the control loop can be improved by increasing the integral term. PMID:24051522

  2. Analysis and Design of a 3rd Order Velocity-Controlled Closed-Loop for MEMS Vibratory Gyroscopes

    PubMed Central

    Wu, Huan-ming; Yang, Hai-gang; Yin, Tao; Jiao, Ji-wei

    2013-01-01

    The time-average method currently available is limited to analyzing the specific performance of the automatic gain control-proportional and integral (AGC-PI) based velocity-controlled closed-loop in a micro-electro-mechanical systems (MEMS) vibratory gyroscope, since it is hard to solve nonlinear functions in the time domain when the control loop reaches to 3rd order. In this paper, we propose a linearization design approach to overcome this limitation by establishing a 3rd order linear model of the control loop and transferring the analysis to the frequency domain. Order reduction is applied on the built linear model's transfer function by constructing a zero-pole doublet, and therefore mathematical expression of each control loop's performance specification is obtained. Then an optimization methodology is summarized, which reveals that a robust, stable and swift control loop can be achieved by carefully selecting the system parameters following a priority order. Closed-loop drive circuits are designed and implemented using 0.35 μm complementary metal oxide semiconductor (CMOS) process, and experiments carried out on a gyroscope prototype verify the optimization methodology that an optimized stability of the control loop can be achieved by constructing the zero-pole doublet, and disturbance rejection capability (D.R.C) of the control loop can be improved by increasing the integral term. PMID:24051522

  3. Rocketdyne - J-2 Saturn V 2nd and 3rd Stage Engine. Chapter 2, Appendix D

    NASA Technical Reports Server (NTRS)

    Coffman, Paul

    2009-01-01

    The J-2 engine was unique in many respects. Technology was not nearly as well-developed in oxygen/hydrogen engines at the start of the J-2 project. As a result, it experienced a number of "teething" problems. It was used in two stages on the Saturn V vehicle in the Apollo Program, as well as on the later Skylab and Apollo/Soyuz programs. In the Apollo Program, it was used on the S-II stage, which was the second stage of the Saturn V vehicle. There were five J-2 engines at the back end of the S-II Stage. In the S-IV-B stage, it was a single engine, but that single engine had to restart. The Apollo mission called for the entire vehicle to reach orbital velocity in low Earth orbit after the first firing of the Saturn-IV-B stage and, subsequently, to fire a second time to go on to the moon. The engine had to be man-rated (worthy of transporting humans). It had to have a high thrust rate and performance associated with oxygen/hydrogen engines, although there were some compromises there. It had to gimbal for thrust vector control. It was an open-cycle gas generator engine delivering up to 230,000 pounds of thrust.

  4. PREFACE: 3rd International Symposium on Laser Ultrasonics and Advanced Sensing

    NASA Astrophysics Data System (ADS)

    2014-06-01

    Based on the use of laser as a coherent and intense light source, the photo-acoustics originated from the discovery made by Alexander Graham Bell was extended to laser-ultrasonics (LU), and it has been applied to wide area of ultrasonics, optics, material characterization and nondestructive inspection. In 1996, a research group for LU was started in the Japanese Society for Nondestructive Inspection (JSNDI), and researches on LU and related topics such as noncontact measurements and elastic wave theories were discussed. Similar activities were pursued also in North America and in Europe. The international symposium on LU was started in Montreal, Canada in 2008 by Jean Pierre Monchalin in order to offer a forum for involved with basic researches and industrial applications of LU. In the second symposium in Bordeaux, France nearly 120 papers were presented. It is our honor to have organized the third symposium, LU2013 on 25-28 June in Yokohama, Japan. The articles published here provide a sample of achievements presented there. In LU2013, we focused on the laser generation and/or detection of acoustic waves, application to nondestructive testing, ultrafast-optoacoustics and innovative instruments. Research achievements in biomedical applications, advanced sensing including noncontact, micro/nanoscale or nonlinear measurements, as well as theory and simulation of ultrasound were also included, considering the interdisciplinary nature of this field. We enjoyed very excellent and informative 3 plenary talks, 11 invited talks, 81 oral and 41 poster presentations with 168 attendees. According to requests, we organized a post deadline poster session to give an opportunity to present recent achievements after the deadline. Contributions of the participants, the scientific and organizing committees are highly appreciated. The conference tour was a dinner cruise to the Tokyo bay, and we hope this experience will remain as a pleasant memory in attendees. As decided in the

  5. FOREWORD: 3rd Symposium on Large TPCs for Low Energy Event Detection

    NASA Astrophysics Data System (ADS)

    Irastorza, Igor G.; Colas, Paul; Gorodetzky, Phillippe

    2007-05-01

    The Third International Symposium on large TPCs for low-energy rare-event detection was held at Carré des sciences, Poincaré auditorium, 25 rue de la Montagne Ste Geneviève in Paris on 11 12 December 2006. This prestigious location belonging to the Ministry of Research is hosted in the former Ecole Polytechnique. The meeting, held in Paris every two years, gathers a significant community of physicists involved in rare event detection. Its purpose is an extensive discussion of present and future projects using large TPCs for low energy, low background detection of rare events (low-energy neutrinos, dark matter, solar axions). The use of a new generation of Micro-Pattern Gaseous Detectors (MPGD) appears to be a promising way to reach this goal. The program this year was enriched by a new session devoted to the detection challenge of polarized gamma rays, relevant novel experimental techniques and the impact on particle physics, astrophysics and astronomy. A very particular feature of this conference is the large variety of talks ranging from purely theoretical to purely experimental subjects including novel technological aspects. This allows discussion and exchange of useful information and new ideas that are emerging to address particle physics experimental challenges. The scientific highlights at the Symposium came on many fronts: Status of low-energy neutrino physics and double-beta decay New ideas on double-beta decay experiments Gamma ray polarization measurement combining high-precision TPCs with MPGD read-out Dark Matter challenges in both axion and WIMP search with new emerging ideas for detection improvements Progress in gaseous and liquid TPCs for rare event detection Georges Charpak opened the meeting with a talk on gaseous detectors for applications in the bio-medical field. He also underlined the importance of new MPGD detectors for both physics and applications. There were about 100 registered participants at the symposium. The successful

  6. PREFACE: 3rd Italian-Pakistani Workshop on Relativistic Astrophysics (IPWRA2011)

    NASA Astrophysics Data System (ADS)

    De Paolis, Francesco; Siddiqui, Azad A.

    2012-03-01

    The Third Italian-Pakistani Workshop on Relativistic Astrophysics was held at the Rectorate of the University of Salento in Lecce on June 20-22, 2011. It follows the first two editions of this Workshop held at the Department of Physics of the University of Salento on 20-22 June 2007 and at ICRA (International Center for Relativistic Astrophysics) in Pescara on 8-10 July 2009. The Proceedings of the first two editions of this Workshop have been published in two special issues of Nuovo Cimento B [1] and General Relativity and Gravitation [2], respectively. The workshop series, whose aim is that of discussing the different aspects (both theoretical and observational) of Relativistic Astrophysics, follows the signature, in 2006, of an agreement between the University of Salento, Italy and the National University of Sciences and Technology (NUST), Pakistan, and aims at promoting scientific and academic cooperation between the parties. The organizing committee of this Workshop has decided to dedicate the present workshop's edition to the celebration of the 65th birthday of the founder of this series of meetings, Prof. Asghar Qadir, one of the greatest Pakistani scientists of any time and a renowned world expert in the theory of general relativity. Many of the Workshop's participants have either been students or collaborators of Asghar Qadir, or both. In Pakistan the words Relativity and Asghar Qadir are synonymous. It would not be entirely wrong to say that anybody who has anything to do with relativity in Pakistan is either his student or a student of one of his students. Asghar Qadir has inspired generations of researchers and teachers, and continues to be a source of inspiration for hard work and dedication. He is a mentor of Pakistani scientists and the equivalent in Pakistan of what John Archibald Wheeler has been in the US. Qadir and Wheeler An autographed picture of John Archibald Wheeler with a young Asghar Qadir Asghar had the rare privilege of being introduced

  7. Use of 2nd and 3rd Level Correlation Analysis for Studying Degradation in Polycrystalline Thin-Film Solar Cells

    SciTech Connect

    Albin, D. S.; del Cueto, J. A.; Demtsu, S. H.; Bansal, S.

    2011-03-01

    The correlation of stress-induced changes in the performance of laboratory-made CdTe solar cells with various 2nd and 3rd level metrics is discussed. The overall behavior of aggregated data showing how cell efficiency changes as a function of open-circuit voltage (Voc), short-circuit current density (Jsc), and fill factor (FF) is explained using a two-diode, PSpice model in which degradation is simulated by systematically changing model parameters. FF shows the highest correlation with performance during stress, and is subsequently shown to be most affected by shunt resistance, recombination and in some cases voltage-dependent collection. Large decreases in Jsc as well as increasing rates of Voc degradation are related to voltage-dependent collection effects and catastrophic shunting respectively. Large decreases in Voc in the absence of catastrophic shunting are attributed to increased recombination. The relevance of capacitance-derived data correlated with both Voc and FF is discussed.

  8. THE 3rd SCHIZOPHRENIA INTERNATIONAL RESEARCH SOCIETY CONFERENCE, 14-18 APRIL 2012, FLORENCE, ITALY: SUMMARIES OF ORAL SESSIONS

    PubMed Central

    Abbs, Brandon; Achalia, Rashmin M; Adelufosi, Adegoke O; Aktener, Ahmet Yiğit; Beveridge, Natalie J; Bhakta, Savita G; Blackman, Rachael K; Bora, Emre; Byun, MS; Cabanis, Maurice; Carrion, Ricardo; Castellani, Christina A; Chow, Tze Jen; Dmitrzak-Weglarz, M; Gayer-Anderson, Charlotte; Gomes, Felipe V; Haut, Kristen; Hori, Hiroaki; Kantrowitz, Joshua T; Kishimoto, Taishiro; Lee, Frankie HF; Lin, Ashleigh; Palaniyappan, Lena; Quan, Meina; Rubio, Maria D; Ruiz de Azúa, Sonia; Sahoo, Saddichha; Strauss, Gregory P; Szczepankiewicz, Aleksandra; Thompson, Andrew D; Trotta, Antonella; Tully, Laura M; Uchida, Hiroyuki; Velthorst, Eva; Young, Jared W; O’Shea, Anne; DeLisi, Lynn E.

    2013-01-01

    The 3rd Schizophrenia International Research Society Conference was held in Florence, Italy, April 14-18, 2012.and this year had as its emphasis, “The Globalization of Research”. Student travel awardees served as rapporteurs for each oral session and focused their summaries on the most significant findings that emerged and the discussions that followed. The following report is a composite of these summaries. We hope that it will provide an overview for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but who would be interested in an update on current investigations ongoing in the field of schizophrenia research. PMID:22910407

  9. An Investigation of the Relationship Between Retention in First Grade and Performance on High Stakes Tests in 3rd Grade

    PubMed Central

    Hughes, Jan N.; Chen, Qi; Thoemmes, Felix; Kwok, Oi-man

    2010-01-01

    The association between grade retention in first grade and passing the third grade state accountability tests, the Texas Assessment of Knowledge and Skills (TAKS) reading and math, was investigated in a sample of 769 students who were recruited into the study when they were in first grade. Of these 769 students, 165 were retained in first grade and 604 were promoted. Using propensity matching, we created five imputed datasets (average N=321) in which promoted and retained students were matched on 67 comprehensive covariates. Using GEE models, we obtained the association between retention and passing the 3rd grade TAKS reading and math tests. The positive association between retention and math scores was significant while the association was marginally significant for reading scores. PMID:20628547

  10. The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24-25, 2015. Workshop Report.

    PubMed

    Kager, Leo; Whelan, Jeremy; Dirksen, Uta; Hassan, Bass; Anninga, Jakob; Bennister, Lindsey; Bovée, Judith V M G; Brennan, Bernadette; Broto, Javier M; Brugières, Laurence; Cleton-Jansen, Anne-Marie; Copland, Christopher; Dutour, Aurélie; Fagioli, Franca; Ferrari, Stefano; Fiocco, Marta; Fleuren, Emmy; Gaspar, Nathalie; Gelderblom, Hans; Gerrand, Craig; Gerß, Joachim; Gonzato, Ornella; van der Graaf, Winette; Hecker-Nolting, Stefanie; Herrero-Martín, David; Klco-Brosius, Stephanie; Kovar, Heinrich; Ladenstein, Ruth; Lancia, Carlo; LeDeley, Marie-Cecile; McCabe, Martin G; Metzler, Markus; Myklebost, Ola; Nathrath, Michaela; Picci, Piero; Potratz, Jenny; Redini, Françoise; Richter, Günther H S; Reinke, Denise; Rutkowski, Piotr; Scotlandi, Katia; Strauss, Sandra; Thomas, David; Tirado, Oscar M; Tirode, Franck; Vassal, Gilles; Bielack, Stefan S

    2016-01-01

    This report summarizes the results of the 3rd Joint ENCCA-WP7, EuroSarc, EEC, PROVABES, and EURAMOS European Bone Sarcoma Network Meeting, which was held at the Children's Cancer Research Institute in Vienna, Austria on September 24-25, 2015. The joint bone sarcoma network meetings bring together European bone sarcoma researchers to present and discuss current knowledge on bone sarcoma biology, genetics, immunology, as well as results from preclinical investigations and clinical trials, to generate novel hypotheses for collaborative biological and clinical investigations. The ultimate goal is to further improve therapy and outcome in patients with bone sarcomas. PMID:27315524

  11. Early Acute Antibody-Mediated Rejection of a Negative Flow Crossmatch 3rd Kidney Transplant with Exclusive Disparity at HLA-DP

    PubMed Central

    Mierzejewska, Beata; Schroder, Paul M.; Baum, Caitlin E.; Blair, Annette; Smith, Connie; Duquesnoy, Rene J.; Marrari, Marilyn; Gohara, Amira; Malhotra, Deepak; Kaw, Dinkar; Liwski, Robert; Rees, Michael A.; Stepkowski, Stanislaw

    2014-01-01

    Donor-specific alloantibodies (DSA) to HLA-DP may cause antibody-mediated rejection (AMR), especially in re-transplants. We describe the immunization history of a patient who received 3 kidney transplants; the 3rd kidney was completely matched except at DPA1 and DPB1. Prior to the 3rd transplant, single antigen bead analysis (SAB) showed DSA reactivity against DPA1 shared by the 1st and 3rd donors, but B and T flow crossmatch (FXM) results were negative. Within 11 days the 3rd transplant underwent acute C4d+ AMR which coincided with the presence of complement (C1q)-binding IgG1 DSA against donor DPA1 and DPB1. Using HLAMatchmaker and SAB, we provide evidence that eplet (epitope) spreading on DPA1 and eplet sharing on differing DPB1 alleles of the 1st and 3rd transplants was associated with AMR. Since weak DSA to DPA1/DPB1 may induce acute AMR with negative FXM, donor DPA1/DPB1 high resolution typing should be considered in sensitized patients with DP-directed DSA. PMID:24755353

  12. [The Original Formulation for Toso-shu (Tusujiu), Created by the 3rd Century Chinese Physician, Hua Tuo].

    PubMed

    Mouri, Chika; Mikage, Masayuki

    2015-01-01

    The original formulation for "Tusujiu," which Japanese people still consume on the morning of January 1st, was created by Hua Tuo, but has not been studied in detail. The book Huatuo Shenyi Bizhuan, found in 1918, describes a concoction, "Biyijiu," that shows great similarity to the current Tusujiu; the ingredients for Biyijiu being rhubarb, atractylodes rhizome, cinnamon bark, platycodon root, zanthoxylum fruit, processed aconite root and smilax rhizome. The procedures for preparing and drinking it are to "pound the ingredients and then put them into a silk bag dyed with madder. During the daytime of the last day of the year, hang the bag in a well to soften the powder. Take the bag out early in the morning of the next day, the first day of the year. Heat the bag in fermented liquor until simmering. Drink the liquid with all family members, doing so while facing east. If one person drinks it, there will be no disease in the family. If the whole family drinks it, there will be no disease in their neighborhood in an area of one square 'li'. In this study, to determine the original formulation for Tusujiu, we examined a number of ancient medical texts from the 3rd to the 13th century that discuss Biyijiu and Tusujiu. As a result, we concluded that "Biyijiu" is likely to be the original formulation developed by Hua Tuo. PMID:26427101

  13. Altered differential hemocyte count in 3rd instar larvae of Drosophila melanogaster as a response to chronic exposure of Acephate

    PubMed Central

    Rajak, Prem; Dutta, Moumita

    2015-01-01

    Acephate, an organophosphate (OP) pesticide, was used to investigate the effects of its chronic exposure on hemocyte abundance in a non-target dipteran insect Drosophila melanogaster. For this purpose, six graded concentrations ranging from 1 to 6 μg/ml were selected, which are below the reported residual values (up to 14 μg/ml) of the chemical. 1st instar larvae were fed with these concentrations up to the 3rd instar stage and accordingly hemolymph smears from these larvae were prepared for differential hemocyte count. Three types of cells are found in Drosophila hemolymph, namely, plasmatocytes, lamellocytes and crystal cells. Plasmatocyte count was found to decrease with successive increase in treatment concentrations. Crystal cells showed an increasing trend in their number. Though the number of lamellocytes was very low, a bimodal response was noticed. Lamellocyte number was found to increase with the initial three concentrations, followed by a dose dependent reduction in their number. As hemocytes are directly linked to the immune system of fruit flies, fluctuations in normal titer of these cells may affect insect immunity. Hemocytes share homologies in their origin and mode of action with the immune cells of higher organisms including man. Thus the present findings suggest that immune cells of humans and other organisms may be affected adversely under chronic exposure to Acephate. PMID:27486365

  14. Organizational Support for the 3rd Summer Institute on Complex Plasmas, July 30 – August 8, 2012

    SciTech Connect

    Lopez, Jose L.

    2012-07-01

    This grant provided partial funds for American graduate students to attend the 3rd Graduate Summer Institute on Complex Plasmas, which was held from July 30 to August 8, 2012 at Seton Hall University in South Orange, New Jersey. The Graduate Summer Institute is a topical series of instructional workshops held bi-annually on the emerging field of complex plasmas that is jointly organized through a collaboration between American and German-European Union plasmas researchers. This specialized program brings together many of the world's leading researchers in the specialized area of complex plasmas, who freely provide instructional lectures and tutorials on the most recent research and discoveries done in this branch of plasma science. The partial funds provided by this grant helped support the travel and accommodation expenses of the participating American students and tutorial instructors. Partial funds further supported the travel and accommodation of three renown American plasma researchers that provided educational tutorials to the thirty-eight participating students from the United States, Europe, and Asia. The organized program afforded a unique opportunity for the participating American graduate students to learn about and engage more deeply in an area of plasma science that is not studied in any of the graduate educational curriculums provided by universities in the United States of America. The educational experience offered by this program provided the necessary knowledge needed by future American plasma researchers to keep the national plasma research effort on the cutting-edge and keep the national plasma community as a global leader.

  15. Evaluation of a model of dissertation supervision for 3rd year B.Sc. undergraduate nursing students.

    PubMed

    Scholefield, Donna; Cox, Georgina

    2016-03-01

    All English universities now offer an all degree undergraduate nursing programme. Many currently use an individual supervision model to support final year dissertation students, but with increased numbers and limited resources new models of supervision are needed. This study evaluated a mixed (group and individual) model of dissertation supervision to determine its effectiveness for a large group of undergraduate nursing students. A sample of 3rd year students and their supervisors were selected from one large university. An evaluation survey was conducted using anonymous internet-based questionnaires and focus groups. The data was analysed using Survey Monkey, SPSS and thematic analysis. A 51% (n = 56/110) response rate (students) and 65% (n = 24/37) for supervisors was obtained. The majority of students and supervisors were satisfied with the new model. There was a mixed response to the group workshops and supervision groups. Three themes emerged from the qualitative data: engaging with the process, motivation to supervise and valuing the process. The supervision process is a struggle but both parties gained considerably from going through the process. In conclusion, a mixed model of supervision together with a range of other learning resources can be an effective approach in supporting students through the dissertation process. PMID:26700648

  16. To keep the catch – that is the question: a personal account of the 3rd Annual EULAR Congress, Stockholm

    PubMed Central

    Wollheim, Frank A

    2002-01-01

    The 3rd Annual EULAR Congress, held in Stockholm on 12–15 June 2002, had a turnout of 8300 delegates, almost identical to last year's record attendance level in Prague. The venue was close to ideal, allowing ample space for poster sessions in the exhibition hall. The manned poster sessions were well attended, even on the last day of the Congress. The numerous invited speakers represented the world's elite, allowing the staging of excellent state-of-the-art podium sessions. The aim of attracting the young scientific community was partly achieved, but individual delegates' dependence on industry sponsorship poses potential problems. The organization was a big improvement compared to that of the two previous congresses. Approximately 1800 abstracts were submitted, an increase of 50%, resulting in a higher quality of accepted abstracts. The satellite symposia held every morning and late afternoon were well attended; thus, industry exposure of new products, both in podium sessions and at the exhibitions, was well accommodated. The Annual EULAR Congress consolidates its position as one of the two most important annual congresses of rheumatology, but EULAR economy and commercial aspects are still too dominant in relation to science. PMID:12223107

  17. The 3rd Canadian Symposium on Hepatitis C Virus: expanding care in the interferon-free era.

    PubMed

    MacParland, Sonya A; Bilodeau, Marc; Grebely, Jason; Bruneau, Julie; Cooper, Curtis; Klein, Marina; Sagan, Selena; Choucha, Norma; Balfour, Louise; Bialystok, Frank; Krajden, Mel; Raven, Jennifer; Roberts, Eve; Russell, Rodney; Houghton, Michael; Tyrrell, D Lorne; Feld, Jordan J

    2014-10-01

    Hepatitis C virus (HCV) currently infects approximately 250,000 individuals in Canada and causes more years of life lost than any other infectious disease in the country. In August 2011, new therapies were approved by Health Canada that have achieved higher response rates among those treated, but are poorly tolerated. By 2014⁄2015, short-course, well-tolerated treatments with cure rates >95% will be available. However, treatment uptake is poor due to structural, financial, geographical, cultural and social barriers. As such, 'Barriers to access to HCV care in Canada' is a crucial topic that must be addressed to decrease HCV disease burden and potentially eliminate HCV in Canada. Understanding how to better care for HCV-infected individuals requires integration across multiple disciplines including researchers, clinical services and policy makers to address the major populations affected by HCV including people who inject drugs, baby boomers, immigrants and Aboriginal and⁄or First Nations people. In 2012, the National CIHR Research Training Program in Hepatitis C organized the 1st Canadian Symposium on Hepatitis C Virus (CSHCV) in Montreal, Quebec. The 2nd CSHCV was held in 2013 in Victoria, British Columbia. Both symposia were highly successful, attracting leading international faculty with excellent attendance leading to dialogue and knowledge translation among attendees of diverse backgrounds. The current article summarizes the 3rd CSHCV, held February 2014, in Toronto, Ontario. PMID:25314353

  18. The 3rd Canadian Symposium on Hepatitis C Virus: Expanding care in the interferon-free era

    PubMed Central

    MacParland, Sonya A; Bilodeau, Marc; Grebely, Jason; Bruneau, Julie; Cooper, Curtis; Klein, Marina; Sagan, Selena M; Choucha, Norma; Balfour, Louise; Bialystok, Frank; Krajden, Mel; Raven, Jennifer; Roberts, Eve; Russell, Rodney; Houghton, Michael; Tyrrell, D Lorne; Feld, Jordan J

    2014-01-01

    Hepatitis C virus (HCV) currently infects approximately 250,000 individuals in Canada and causes more years of life lost than any other infectious disease in the country. In August 2011, new therapies were approved by Health Canada that have achieved higher response rates among those treated, but are poorly tolerated. By 2014/2015, short-course, well-tolerated treatments with cure rates >95% will be available. However, treatment uptake is poor due to structural, financial, geographical, cultural and social barriers. As such, ‘Barriers to access to HCV care in Canada’ is a crucial topic that must be addressed to decrease HCV disease burden and potentially eliminate HCV in Canada. Understanding how to better care for HCV-infected individuals requires integration across multiple disciplines including researchers, clinical services and policy makers to address the major populations affected by HCV including people who inject drugs, baby boomers, immigrants and Aboriginal and/or First Nations people. In 2012, the National CIHR Research Training Program in Hepatitis C organized the 1st Canadian Symposium on Hepatitis C Virus (CSHCV) in Montreal, Quebec. The 2nd CSHCV was held in 2013 in Victoria, British Columbia. Both symposia were highly successful, attracting leading international faculty with excellent attendance leading to dialogue and knowledge translation among attendees of diverse backgrounds. The current article summarizes the 3rd CSHCV, held February 2014, in Toronto, Ontario. PMID:25314353

  19. Effects of using relaxation breathing training to reduce music performance anxiety in 3rd to 6th graders.

    PubMed

    Su, Yu-Huei; Luh, Jer-Junn; Chen, Hsin-I; Lin, Chao-Chen; Liao, Miin-Jiun; Chen, Heng-Shuen

    2010-06-01

    The current study examined the effects of applying relaxation breathing training (RBT) as a means to reduce music performance anxiety (MPA) in young, talented musicians. A group of 59 young musicians from 3rd to 6th grade participated in this study, and all of them started RBT twice a week for 2 months prior to the examination. Four tests--2 mos, 1 mos, half an hour and 5 min before the examination--were conducted to examine the level of MPA after the application of RBT. Results show that the degree of MPA 5 min before the trial was lower than the degree of performance anxiety half an hour before the jury (t = -3.683, p < 0.01), which indicated that the RBT was associated with a decrease in MPA. Although a series of RBT exercises was applied, results indicated that when approaching the date of examination, the degree of performance anxiety still increased and reached its maximum half an hour before the jury. The recommendation for future studies is to combine the application of RBT with other methods to expand its effect in reducing MPA. PMID:20795337

  20. Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA

    PubMed Central

    Friew, Yeshitila N; Boyko, Vitaly; Hu, Wei-Shau; Pathak, Vinay K

    2009-01-01

    Background Host restriction factor APOBEC3G (A3G) blocks human immunodeficiency virus type 1 (HIV-1) replication by G-to-A hypermutation, and by inhibiting DNA synthesis and provirus formation. Previous reports have suggested that A3G is a dimer and its virion incorporation is mediated through interactions with viral or nonviral RNAs and/or HIV-1 Gag. We have now employed a bimolecular fluorescence complementation assay (BiFC) to analyze the intracellular A3G-A3G, A3G-RNA, and A3G-Gag interactions in living cells by reconstitution of yellow fluorescent protein (YFP) from its N- or C-terminal fragments. Results The results obtained with catalytic domain 1 and 2 (CD1 and CD2) mutants indicate that A3G-A3G and A3G-Gag multimerization is dependent on an intact CD1 domain, which is required for RNA binding. A mutant HIV-1 Gag that exhibits reduced RNA binding also failed to reconstitute BiFC with wild-type A3G, indicating a requirement for both HIV-1 Gag and A3G to bind to RNA for their multimerization. Addition of a non-specific RNA binding peptide (P22) to the N-terminus of a CD1 mutant of A3G restored BiFC and virion incorporation, but failed to inhibit viral replication, indicating that the mutations in CD1 resulted in additional defects that interfere with A3G's antiviral activity. Conclusion These studies establish a robust BiFC assay for analysis of intracellular interactions of A3G with other macromolecules. The results indicate that in vivo A3G is a monomer that forms multimers upon binding to RNA. In addition, we observed weak interactions between wild-type A3G molecules and RNA binding-defective mutants of A3G, which could explain previously described protein-protein interactions between purified A3G molecules. PMID:19497112

  1. Analysis of time-variant quadratic phase couplings in the tracé alternant EEG by recursive estimation of 3rd-order time-frequency distributions.

    PubMed

    Helbig, Marko; Schwab, Karin; Leistritz, Lutz; Eiselt, Michael; Witte, Herbert

    2006-10-15

    The quantification of transient quadratic phase couplings (QPC) by means of time-variant bispectral analysis is a useful approach to explain several interrelations between signal components. A generalized recursive estimation approach for 3rd-order time-frequency distributions (3rd-order TFD) is introduced. Based on 3rd-order TFD, time-variant estimations of biamplitude (BA), bicoherence (BC) and phase bicoherence (PBC) can be derived. Different smoothing windows and local moment functions for an optimization of the estimation properties are investigated and compared. The methods are applied to signal simulations and EEG signals, and it can be shown that the new time-variant bispectral analysis results in a reliable quantification of QPC in the tracé alternant EEG of healthy neonates. PMID:16737739

  2. PREFACE: Special section featuring selected papers from the 3rd International Workshop on Numerical Modelling of High Temperature Superconductors Special section featuring selected papers from the 3rd International Workshop on Numerical Modelling of High Temperature Superconductors

    NASA Astrophysics Data System (ADS)

    Granados, Xavier; Sánchez, Àlvar; López-López, Josep

    2012-10-01

    The development of superconducting applications and superconducting engineering requires the support of consistent tools which can provide models for obtaining a good understanding of the behaviour of the systems and predict novel features. These models aim to compute the behaviour of the superconducting systems, design superconducting devices and systems, and understand and test the behavior of the superconducting parts. 50 years ago, in 1962, Charles Bean provided the superconducting community with a model efficient enough to allow the computation of the response of a superconductor to external magnetic fields and currents flowing through in an understandable way: the so called critical-state model. Since then, in addition to the pioneering critical-state approach, other tools have been devised for designing operative superconducting systems, allowing integration of the superconducting design in nearly standard electromagnetic computer-aided design systems by modelling the superconducting parts with consideration of time-dependent processes. In April 2012, Barcelona hosted the 3rd International Workshop on Numerical Modelling of High Temperature Superconductors (HTS), the third in a series of workshops started in Lausanne in 2010 and followed by Cambridge in 2011. The workshop reflected the state-of-the-art and the new initiatives of HTS modelling, considering mathematical, physical and technological aspects within a wide and interdisciplinary scope. Superconductor Science and Technology is now publishing a selection of papers from the workshop which have been selected for their high quality. The selection comprises seven papers covering mathematical, physical and technological topics which contribute to an improvement in the development of procedures, understanding of phenomena and development of applications. We hope that they provide a perspective on the relevance and growth that the modelling of HTS superconductors has achieved in the past 25 years.

  3. When should orthostatic blood pressure changes be evaluated in elderly: 1st, 3rd or 5th minute?

    PubMed

    Soysal, Pinar; Aydin, Ali Ekrem; Koc Okudur, Saadet; Isik, Ahmet Turan

    2016-01-01

    Detection of orthostatic hypotension (OH) is very important in geriatric practice, since OH is associated with mortality, ischemic stroke, falls, cognitive failure and depression. It was aimed to determine the most appropriate time for measuring blood pressure in transition from supine to upright position in order to diagnose OH in elderly. Comprehensive geriatric assessment (CGA) including Head up Tilt Table (HUT) test was performed in 407 geriatric patients. Orthostatic changes were assessed separately for the 1st, 3rd and 5th minutes (HUT1, HUT3 and HUT5, respectively) taking the data in supine position as the basis. The mean age, recurrent falls, presence of dementia and Parkinson's disease, number of drugs, alpha-blocker and anti-dementia drug use, and fasting blood glucose levels were significantly higher in the patients with versus without OH; whereas, albumin and 25-hydroxy vitamin D levels were significantly lower (p<0.05). However, different from HUT3 and HUT5, Charlson Comorbidity Index and the prevalence of diabetes mellitus were higher, the use of antidiabetics, antipsychotics, benzodiazepine, opioid and levodopa were more common (p<0.05). Statistical significance of the number of drugs and fasting blood glucose level was prominent in HUT1 as compared to HUT3 (p<0.01, p<0.05). Comparison of the patients that had OH only in HUT1, HUT3or HUT5 revealed no difference in terms of CGA parameters. These results suggests that orthostatic blood pressure changes determined at the 1st minute might be more important for geriatric practice. Moreover, 1st minute measurement might be more convenient in the elderly as it requires shorter time in practice. PMID:27077324

  4. Electrocradiographic Qrs Axis, Q Wave and T-wave Changes in 2nd and 3rd Trimester of Normal Pregnancy

    PubMed Central

    S., Chandrasekharappa; Brid, S.V

    2014-01-01

    Background: Pregnancy although a physiological phenomena affects all the functions of the maternal body and brings about remarkable changes in the cardiovascular system. The cardiovascular changes and many of the physiological adaptations of normal pregnancy alter the physical findings thus, sometimes misleading the diagnosis of heart disease. Pregnancy also brings about various changes in the electrocardiogram, further confusing with that of heart disease. This study is undertaken to highlight the effect of normal pregnancy on the QRS axis, Q wave and T-wave of the Electrocardiogram and thereby helps us to distinguish it from that of pathological changes. Objectives: To study the effect of normal pregnancy on the QRS axis, Q wave and T-wave in the electrocardiogram and to compare with that of normal non pregnant women. Materials and Methods: Fifty normal pregnant women in 2nd and 3rd trimester each between 20– 35 y of age and 50 normal non pregnant women of the same age group were selected for the study. A 12 lead ECG was recorded by using ECG machine with special emphasis on QRS axis, Q wave and T-wave changes and all the parameters were analysed. Results: The ECG changes observed in our study include, deviation of QRS axis towards left as pregnancy advanced, significant increased incidence of occurrence of prominent Q waves in lead II, III and avF in pregnant group (p < 0.05 ) and, T-wave abnormalities like flat and inverted T-waves in lead III, V1 – V3 were more frequent in pregnant group ( p<0.05 ) than in non pregnant group. Conclusion:Normal pregnancy brings about various changes in ECG. These changes during pregnancy should be interpretated with caution by the physicians. It is necessary to understand the normal physiological changes which in turn help us in better management of those with cardiac disease. PMID:25386425

  5. Implications of Technology for Teaching and Learning. Annual Professional Education Seminar of Central States Colleges and Universities (3rd, November, 1967).

    ERIC Educational Resources Information Center

    Woodruff, Asahel; Froyen, Len

    This report of the proceedings of the 3rd Annual Professional Education Seminar of the Central States Colleges and Universities centers upon the implications of technology for teaching and learning and contains addresses delivered, including "Some Concerns Related to Technology in Education," by Len Froyen; and "Implications of Technology for…

  6. The Relationship between Perceived and Ideal Body Size and Body Mass Index in 3rd-Grade Low Socioeconomic Hispanic Children

    ERIC Educational Resources Information Center

    Fisher, Allison; Lange, Mary Anne; Young-Cureton, Virginia; Canham, Daryl

    2005-01-01

    Very little is known about body satisfaction among minority children. This study examined the relationship between perceived and actual body size and Body Mass Index among 43 low-socioeconomic Hispanic 3rd-graders. Researchers measured participants' Body Mass Index; students self-reported Perceived Ideal Self Image and Perceived Actual Self Image…

  7. Midwest Child-Parent Center (CPC) PreK-3rd Grade School Reform Model: Impacts on Child and Family Outcomes over Time

    ERIC Educational Resources Information Center

    Gaylor, Erika; Spiker, Donna; Wei, Xin; Lease, Erin; Reynolds, Arthur

    2015-01-01

    This presentation reports on the goals and preliminary outcomes of the Child-Parent Centers (CPC) Expansion Project, which is a PreK to 3rd grade school reform model aimed at improving the short- and long-term outcomes of participating children and families. The model provides continuous education and family support services to schools serving a…

  8. APOBEC3G Complexes Decrease Human Immunodeficiency Virus Type 1 Production ▿

    PubMed Central

    Martin, Kenneth L.; Johnson, Megan; D'Aquila, Richard T.

    2011-01-01

    APOBEC3G (A3G) is packaged into human immunodeficiency virus type 1 (HIV-1) virions unless HIV-1 virion infectivity factor (Vif) counteracts it. Virion A3G restricts HIV-1 reverse transcription and integration in target cells. Some A3G in producer cells colocalizes with specific cytoplasmic structures, in what are called “A3G complexes” here. Functional effects of producer cell A3G complexes on HIV-1 replication were studied. HeLa cells were cotransfected with HIV-1 constructs producing pseudoviruses, as well as either wild-type (WT) A3G or a mutant A3G (C97A, Y124A, W127A, or D128K A3G). Pseudovirus particle production was decreased from cells expressing any of the A3Gs that formed complexes by 24 h after transfection, relative to cells with C97A A3G that did not form detectable A3G complexes by 24 h or A3G-negative cells. The intracellular HIV-1 Gag half-life was shorter in cells containing A3G complexes than in those lacking complexes. HIV-1 virion output was decreased in a single round of replication from a T cell line containing A3G complexes (CEM cells) after infection with Vif-negative HIV-1, compared to Vif-positive HIV-1 that depleted A3G. Levels of production of Vif-negative and Vif-positive virus were similar from cells not containing A3G (CEM-SS cells). Knockdown of the mRNA processing body (P-body) component RCK/p54, eliminated A3G complex formation, and increased HIV-1 production. We conclude that endogenous A3G complexes in producer cells decrease HIV-1 production if not degraded by Vif. PMID:21752914

  9. PREFACE: 3rd International Conference on Science & Engineering in Mathematics, Chemistry and Physics 2015 (ScieTech 2015)

    NASA Astrophysics Data System (ADS)

    Gaol, F. L.

    2015-06-01

    The 3rd International Conference on Science & Engineering in Mathematics, Chemistry and Physics 2015 (ScieTech 2015), was held at The Westin Resort Nusa Dua, Bali on 31 January - 1 February 2015. The ScieTech 2015 conference is aimed to bring together researchers, engineers and scientists from around the world. ScieTech 2015 is placed on promoting interaction between the theoretical, experimental, and applied communities, so that a high level exchange is achieved in new and emerging areas within mathematics, chemistry and physics. As we already know that science and technology have brought tremendous benefits for human civilization. People are becoming healthier, wealthier, better educated, more peaceful, increasingly connected, and living longer. Of course, science and technology provide many answers to global challenges, but we will face more complex problems in the next decade due to increasing world population, limitation of energy, and climate change. Therefore, researchers should be more active in conducting research that enables collaboration between one and the others. Interdisciplinary cooperation is absolutely necessary in order to create a smart system for solving the global problems. We need a global and general long-term view of the future with long-range goals for solving complex problems in next decade. Therefore the conference was held to be a forum for researchers from different disciplines to start collaborating and conducting research that provides a solution to the global issues. The theme of ScieTech 2015 was ''The interdisciplinary Application between Mathematics, Chemistry and Physics to enhance the Quality of Life''. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting conference program as well as the invited and plenary speakers. This year, we received 197 papers and after rigorous review, 59 papers were accepted. The participants came from 19

  10. Effect on Physical Activity of a Randomized Afterschool Intervention for Inner City Children in 3rd to 5th Grade

    PubMed Central

    Crouter, Scott E.; de Ferranti, Sarah D.; Whiteley, Jessica; Steltz, Sarah K.; Osganian, Stavroula K.; Feldman, Henry A.; Hayman, Laura L.

    2015-01-01

    Background Less than 45% of U.S. children meet the 60 min.d-1 physical activity (PA) guideline. Structured after-school PA programing is one approach to help increase activity levels. This study aimed to evaluate the feasibility and short-term impact of a supervised after-school PA and nutrition education program on activity levels. Methods Forty-two 3rd-5th graders from an inner-city school in Boston, MA were randomly assigned to a 10-wk after-school program of either: 1) weekly nutrition education, or 2) weekly nutrition education plus supervised PA 3 d.wk-1 at a community-based center. At baseline and follow-up, PA was measured using accelerometry and fitness (VO2max) was estimated using the PACER 15-m shuttle run. Additional measures obtained were non-fasting finger stick total cholesterol (TC) and glucose levels, waist circumference (WC), body mass index (BMI), percent body fat (%BF), and blood pressure (BP). Values are presented as mean±SE, unless noted otherwise. Results Thirty-six participants completed the study (mean±SD; age 9.7±0.9 years). Participants attended >80% of the sessions. After adjusting for accelerometer wear time and other design factors, light and moderate-to-vigorous PA (MVPA) increased in the nutrition+PA group (+21.5±14.5 and +8.6±8.0 min.d-1, respectively) and decreased in the nutrition only group (-35.2±16.3 and -16.0±9.0 min.d-1, respectively); mean difference between groups of 56.8±21.7 min.d-1 (light PA, p = 0.01) and 24.5±12.0 min.d-1 (MVPA, p = 0.04). Time spent in sedentary behaviors declined in the nutrition+PA group (-14.8±20.7 min.d-1) and increased in the nutrition only group (+55.4±23.2 min.d-1); mean difference between groups of -70.2±30.9 min.d-1 (p = 0.02). Neither group showed changes in TC, BP, WC, %BF, BMI percentile, or fitness (p>0.05). Conclusions The supervised afterschool community-based nutrition and PA program was well accepted and had high attendance. The changes in light PA and MVPA has potential

  11. PREFACE: 3rd International Conference on Geological, Geographical, Aerospace and Earth Science 2015 (AeroEarth 2015)

    NASA Astrophysics Data System (ADS)

    Gaol, F. L.

    2016-02-01

    The 3rd International Conferences on Geological, Geographical, Aerospaces and Earth Sciences 2015 (AeroEarth 2015), was held at The DoubleTree Hilton, Jakarta, Indonesia during 26 - 27 September 2015. The 1st AeoroEarth was held succefully in Jakarta in 2013. The success continued to The 2nd AeroEarth 2014 that was held in Kuta Bali, Indonesia. The publications were published by EES IOP in http://iopscience.iop.org/1755-1315/19/1 and http://iopscience.iop.org/1755-1315/23/1 respectively. The AeroEarth 2015 conference aims to bring together researchers, engineers and scientists from around the world. Through research and development, Earth's scientists have the power to preserve the planet's different resource domains by providing expert opinion and information about the forces which make life possible on Earth. The theme of AeroEarth 2015 is ''Earth and Aerospace Sciences : Challenges and Opportunities'' Earth provides resources and the exact conditions to make life possible. However, with the advent of technology and industrialization, the Earth's resources are being pushed to the brink of depletion. Non-sustainable industrial practices are not only endangering the supply of the Earth's natural resources, but are also putting burden on life itself by bringing about pollution and climate change. A major role of earth science scholars is to examine the delicate balance between the Earth's resources and the growing demands of industrialization. Through research and development, earth scientists have the power to preserve the planet's different resource domains by providing expert opinion and information about the forces which make life possible on Earth. We would like to express our sincere gratitude to all in the Technical Program Committee who have reviewed the papers and developed a very interesting Conference Program as well as the invited and plenary speakers. This year, we received 78 papers and after rigorous review, 18 papers were accepted. The participants

  12. Production of ethanol 3G from Kappaphycus alvarezii: evaluation of different process strategies.

    PubMed

    Hargreaves, Paulo Iiboshi; Barcelos, Carolina Araújo; da Costa, Antonio Carlos Augusto; Pereira, Nei

    2013-04-01

    This study evaluated the potential of Kappaphycus alvarezii as feedstock for ethanol production, i.e. ethanol 3G. First, aquatic biomass was subjected to a diluted acid pretreatment. This acid pretreatment generated two streams--a galactose-containing liquid fraction and a cellulose-containing solid fraction, which were investigated to determine their fermentability with the following strategies: a single-stream process (simultaneous saccharification and co-fermentation (SSCF) of both fractions altogether), which achieved 64.3 g L(-1) of ethanol, and a two-stream process (fractions were fermented separately), which resulted in 38 g L(-1) of ethanol from the liquid fraction and 53.0 g L(-1) from the simultaneous saccharification and fermentation (SSF) of the solid fraction. Based on the average fermentable carbohydrate concentration, it was possible to obtain 105 L of ethanol per ton of dry seaweed. These preliminaries results indicate that the use of the macro-algae K. alvarezii has a good potential feedstock for bioethanol production. PMID:23500583

  13. Crystal structures of APOBEC3G N-domain alone and its complex with DNA

    PubMed Central

    Xiao, Xiao; Li, Shu-Xing; Yang, Hanjing; Chen, Xiaojiang S.

    2016-01-01

    APOBEC3G (A3G) is a potent restriction factor of HIV-1. The N-terminal domain of A3G (A3G-CD1) is responsible for oligomerization and nucleic acid binding, both of which are essential for anti-HIV activity. As a countermeasure, HIV-1 viral infectivity factor (Vif) binds A3G-CD1 to mediate A3G degradation. The structural basis for the functions of A3G-CD1 remains elusive. Here, we report the crystal structures of a primate A3G-CD1 (rA3G-CD1) alone and in complex with single-stranded DNA (ssDNA). rA3G-CD1 shares a conserved core structure with the previously determined catalytic APOBECs, but displays unique features for surface charge, dimerization and nucleic acid binding. Its co-crystal structure with ssDNA reveals how the conformations of loops and residues surrounding the Zn-coordinated centre (Zn-centre) change upon DNA binding. The dimerization interface of rA3G-CD1 is important for oligomerization, nucleic acid binding and Vif-mediated degradation. These findings elucidate the molecular basis of antiviral mechanism and HIV-Vif targeting of A3G. PMID:27480941

  14. Crystal structures of APOBEC3G N-domain alone and its complex with DNA.

    PubMed

    Xiao, Xiao; Li, Shu-Xing; Yang, Hanjing; Chen, Xiaojiang S

    2016-01-01

    APOBEC3G (A3G) is a potent restriction factor of HIV-1. The N-terminal domain of A3G (A3G-CD1) is responsible for oligomerization and nucleic acid binding, both of which are essential for anti-HIV activity. As a countermeasure, HIV-1 viral infectivity factor (Vif) binds A3G-CD1 to mediate A3G degradation. The structural basis for the functions of A3G-CD1 remains elusive. Here, we report the crystal structures of a primate A3G-CD1 (rA3G-CD1) alone and in complex with single-stranded DNA (ssDNA). rA3G-CD1 shares a conserved core structure with the previously determined catalytic APOBECs, but displays unique features for surface charge, dimerization and nucleic acid binding. Its co-crystal structure with ssDNA reveals how the conformations of loops and residues surrounding the Zn-coordinated centre (Zn-centre) change upon DNA binding. The dimerization interface of rA3G-CD1 is important for oligomerization, nucleic acid binding and Vif-mediated degradation. These findings elucidate the molecular basis of antiviral mechanism and HIV-Vif targeting of A3G. PMID:27480941

  15. Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity.

    PubMed

    Pinto, Yishay; Gabay, Orshay; Arbiza, Leonardo; Sams, Aaron J; Keinan, Alon; Levanon, Erez Y

    2016-05-01

    The gradual accumulation of mutations by any of a number of mutational processes is a major driving force of divergence and evolution. Here, we investigate a potentially novel mutational process that is based on the activity of members of the AID/APOBEC family of deaminases. This gene family has been recently shown to introduce-in multiple types of cancer-enzyme-induced clusters of co-occurring somatic mutations caused by cytosine deamination. Going beyond somatic mutations, we hypothesized that APOBEC3-following its rapid expansion in primates-can introduce unique germline mutation clusters that can play a role in primate evolution. In this study, we tested this hypothesis by performing a comprehensive comparative genomic screen for APOBEC3-induced mutagenesis patterns across different hominids. We detected thousands of mutation clusters introduced along primate evolution which exhibit features that strongly fit the known patterns of APOBEC3G mutagenesis. These results suggest that APOBEC3G-induced mutations have contributed to the evolution of all genomes we studied. This is the first indication of site-directed, enzyme-induced genome evolution, which played a role in the evolution of both modern and archaic humans. This novel mutational mechanism exhibits several unique features, such as its higher tendency to mutate transcribed regions and regulatory elements and its ability to generate clusters of concurrent point mutations that all occur in a single generation. Our discovery demonstrates the exaptation of an anti-viral mechanism as a new source of genomic variation in hominids with a strong potential for functional consequences. PMID:27056836

  16. Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity

    PubMed Central

    Pinto, Yishay; Gabay, Orshay; Arbiza, Leonardo; Sams, Aaron J.; Keinan, Alon

    2016-01-01

    The gradual accumulation of mutations by any of a number of mutational processes is a major driving force of divergence and evolution. Here, we investigate a potentially novel mutational process that is based on the activity of members of the AID/APOBEC family of deaminases. This gene family has been recently shown to introduce—in multiple types of cancer—enzyme-induced clusters of co-occurring somatic mutations caused by cytosine deamination. Going beyond somatic mutations, we hypothesized that APOBEC3—following its rapid expansion in primates—can introduce unique germline mutation clusters that can play a role in primate evolution. In this study, we tested this hypothesis by performing a comprehensive comparative genomic screen for APOBEC3-induced mutagenesis patterns across different hominids. We detected thousands of mutation clusters introduced along primate evolution which exhibit features that strongly fit the known patterns of APOBEC3G mutagenesis. These results suggest that APOBEC3G-induced mutations have contributed to the evolution of all genomes we studied. This is the first indication of site-directed, enzyme-induced genome evolution, which played a role in the evolution of both modern and archaic humans. This novel mutational mechanism exhibits several unique features, such as its higher tendency to mutate transcribed regions and regulatory elements and its ability to generate clusters of concurrent point mutations that all occur in a single generation. Our discovery demonstrates the exaptation of an anti-viral mechanism as a new source of genomic variation in hominids with a strong potential for functional consequences. PMID:27056836

  17. Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif

    PubMed Central

    Britan-Rosich, Elena; Nowarski, Roni; Kotler, Moshe

    2011-01-01

    In the absence of HIV-1 Vif protein, the host antiviral deaminase APOBEC3G (A3G) restricts the production of infectious HIV-1 by deamination of dC residues in the negative ssDNA produced by reverse transcription. The Vif protein averts the lethal threat of deamination by precluding the packaging of A3G into assembling virions by mediating proteasomal degradation of A3G. In spite of this robust Vif activity, residual A3G molecules that escape degradation and incorporate into newly assembled virions are potentially deleterious to the virus. We hypothesized that virion-associated Vif inhibits A3G enzymatic activity, and therefore prevents lethal mutagenesis of the newly synthesized viral DNA. Here we show that: (i) Vif-proficient HIV-1 particles released from H9 cells contain A3G with lower specific activity compared with Δvif virus associated A3G; (ii) Encapsidated HIV-1 Vif inhibits the deamination activity of recombinant A3G, and (iii) Purified HIV-1 Vif protein and the Vif-derived peptide Vif25-39 inhibit A3G activity in vitro at nanomolar concentrations in an uncompetitive manner. Our results manifest the potentiality of Vif to control the deamination threat in virions or in the pre-integration complexes (PICs) following entry to target cells. Hence, virion-associated Vif could serve as a last line of defense, protecting the virus against A3G anti-viral activity. PMID:21763507

  18. APOBEC3G enhances lymphoma cell radioresistance by promoting cytidine deaminase-dependent DNA repair.

    PubMed

    Nowarski, Roni; Wilner, Ofer I; Cheshin, Ori; Shahar, Or D; Kenig, Edan; Baraz, Leah; Britan-Rosich, Elena; Nagler, Arnon; Harris, Reuben S; Goldberg, Michal; Willner, Itamar; Kotler, Moshe

    2012-07-12

    APOBEC3 proteins catalyze deamination of cytidines in single-stranded DNA (ssDNA), providing innate protection against retroviral replication by inducing deleterious dC > dU hypermutation of replication intermediates. APOBEC3G expression is induced in mitogen-activated lymphocytes; however, no physiologic role related to lymphoid cell proliferation has yet to be determined. Moreover, whether APOBEC3G cytidine deaminase activity transcends to processing cellular genomic DNA is unknown. Here we show that lymphoma cells expressing high APOBEC3G levels display efficient repair of genomic DNA double-strand breaks (DSBs) induced by ionizing radiation and enhanced survival of irradiated cells. APOBEC3G transiently accumulated in the nucleus in response to ionizing radiation and was recruited to DSB repair foci. Consistent with a direct role in DSB repair, inhibition of APOBEC3G expression or deaminase activity resulted in deficient DSB repair, whereas reconstitution of APOBEC3G expression in leukemia cells enhanced DSB repair. APOBEC3G activity involved processing of DNA flanking a DSB in an integrated reporter cassette. Atomic force microscopy indicated that APOBEC3G multimers associate with ssDNA termini, triggering multimer disassembly to multiple catalytic units. These results identify APOBEC3G as a prosurvival factor in lymphoma cells, marking APOBEC3G as a potential target for sensitizing lymphoma to radiation therapy. PMID:22645179

  19. APOBEC3G exerts tumor suppressive effects in human hepatocellular carcinoma.

    PubMed

    Chang, Li-Ching; Kuo, Ting-Yin; Liu, Ching-Wen; Chen, Yaw-Sen; Lin, Hsi-Hsun; Wu, Pei-Fung

    2014-04-01

    In this study, we collected 44 hepatitis B virus surface antigen positivity HBsAg (+) tumor and nontumor hepatocellular tissues from hepatocellular carcinoma (HCC) patients during hepatectomy, and quantified the APOBEC3G (A3G) mRNA by using a real-time PCR. Our results showed higher expression of A3G mRNA in the nontumor tissues than in the tumor tissues of the HBsAg (+) HCC patients. To further investigate this phenomenon, we constructed a pLV-A3G vector and transfected it into the human HCC cell line, Hep 3B. The results of an immunofluorescence analysis showed the overexpression of A3G in the cytoplasm. We then evaluated A3G cytotoxicity by using a cell viability assay (MTS assay), the results of which showed that Hep 3B cell viability was 88 and 58% after the transfection of pLV and pLV-A3G, respectively, indicating the growth inhibitory effects of A3G on Hep 3B cells. To further evaluate the tumor suppressive effects of A3G, we used a plastic pipette tip to scratch Hep 3B cells grown on a culture dish (to 70-80% confluence) after transfection with pLV-A3G. Our data indicated a ratio of wound closure of 100% in the control cells and in the pLV-expressing cells, compared with 43% in the pLV-A3G-overexpressing cells, 72 h after the wound scratch, as observed using phase-contrast microscopy. These results indicated that A3G inhibits wound healing in Hep 3B cells. Overall, our results suggest that A3G inhibits the growth of human hepatoma cells. PMID:24500029

  20. Biochemical Basis of Immunological and Retroviral Responses to DNA-targeted Cytosine Deamination by Activation-induced Cytidine Deaminase and APOBEC3G*

    PubMed Central

    Chelico, Linda; Pham, Phuong; Petruska, John; Goodman, Myron F.

    2009-01-01

    Activation-induced cytidine deaminase (AID) and APOBEC3G catalyze deamination of cytosine to uracil on single-stranded DNA, thereby setting in motion a regulated hypermutagenic process essential for human well-being. However, if regulation fails, havoc ensues. AID plays a central role in the synthesis of high affinity antibodies, and APOBEC3G inactivates human immunodeficiency virus-1. This minireview highlights biochemical and structural properties of AID and APOBEC3G, showing how studies using the purified enzymes provide valuable insight into the considerably more complex biology governing antibody generation and human immunodeficiency virus inactivation. PMID:19684020

  1. Inhibition of APOBEC3G activity impedes double-stranded DNA repair.

    PubMed

    Prabhu, Ponnandy; Shandilya, Shivender M D; Britan-Rosich, Elena; Nagler, Adi; Schiffer, Celia A; Kotler, Moshe

    2016-01-01

    The cellular cytidine deaminase APOBEC3G (A3G) was first described as an anti-HIV-1 restriction factor, acting by directly deaminating reverse transcripts of the viral genome. HIV-1 Vif neutralizes the activity of A3G, primarily by mediating degradation of A3G to establish effective infection in host target cells. Lymphoma cells, which express high amounts of A3G, can restrict Vif-deficient HIV-1. Interestingly, these cells are more stable in the face of treatments that result in double-stranded DNA damage, such as ionizing radiation and chemotherapies. Previously, we showed that the Vif-derived peptide (Vif25-39) efficiently inhibits A3G deamination, and increases the sensitivity of lymphoma cells to ionizing radiation. In the current study, we show that additional peptides derived from Vif, A3G, and APOBEC3F, which contain the LYYF motif, inhibit deamination activity. Each residue in the Vif25-39 sequence moderately contributes to the inhibitory effect, whereas replacing a single residue in the LYYF motif completely abrogates inhibition of deamination. Treatment of A3G-expressing lymphoma cells exposed to ionizing radiation with the new inhibitory peptides reduces double-strand break repair after irradiation. Incubation of cultured irradiated lymphoma cells with peptides that inhibit double-strand break repair halts their propagation. These results suggest that A3G may be a potential therapeutic target that is amenable to peptide and peptidomimetic inhibition. PMID:26460502

  2. A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation

    PubMed Central

    Ishibashi, Ryoichi; Takemoto, Minoru; Akimoto, Yoshihiro; Ishikawa, Takahiro; He, Peng; Maezawa, Yoshiro; Sakamoto, Kenichi; Tsurutani, Yuya; Ide, Shintaro; Ide, Kana; Kawamura, Harukiyo; Kobayashi, Kazuki; Tokuyama, Hirotake; Tryggvason, Karl; Betsholtz, Christer; Yokote, Koutaro

    2016-01-01

    Kidney diseases including diabetic nephropathy have become huge medical problems, although its precise mechanisms are still far from understood. In order to increase our knowledge about the patho-physiology of kidney, we have previously identified >300 kidney glomerulus-enriched transcripts through large-scale sequencing and microarray profiling of the mouse glomerular transcriptome. One of the glomerulus-specific transcripts identified was semaphorin 3G (Sema3G) which belongs to the semaphorin family. The aim of this study was to analyze both the in vivo and in vitro functions of Sema3G in the kidney. Sema3G was expressed in glomerular podocytes. Although Sema3G knockout mice did not show obvious glomerular defects, ultrastructural analyses revealed partially aberrant podocyte foot processes structures. When these mice were injected with lipopolysaccharide to induce acute inflammation or streptozotocin to induce diabetes, the lack of Sema3G resulted in increased albuminuria. The lack of Sema3G in podocytes also enhanced the expression of inflammatory cytokines including chemokine ligand 2 and interleukin 6. On the other hand, the presence of Sema3G attenuated their expression through the inhibition of lipopolysaccharide-induced Toll like receptor 4 signaling. Taken together, our results surmise that the Sema3G protein is secreted by podocytes and protects podocytes from inflammatory kidney diseases and diabetic nephropathy. PMID:27180624

  3. A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.

    PubMed

    Ishibashi, Ryoichi; Takemoto, Minoru; Akimoto, Yoshihiro; Ishikawa, Takahiro; He, Peng; Maezawa, Yoshiro; Sakamoto, Kenichi; Tsurutani, Yuya; Ide, Shintaro; Ide, Kana; Kawamura, Harukiyo; Kobayashi, Kazuki; Tokuyama, Hirotake; Tryggvason, Karl; Betsholtz, Christer; Yokote, Koutaro

    2016-01-01

    Kidney diseases including diabetic nephropathy have become huge medical problems, although its precise mechanisms are still far from understood. In order to increase our knowledge about the patho-physiology of kidney, we have previously identified >300 kidney glomerulus-enriched transcripts through large-scale sequencing and microarray profiling of the mouse glomerular transcriptome. One of the glomerulus-specific transcripts identified was semaphorin 3G (Sema3G) which belongs to the semaphorin family. The aim of this study was to analyze both the in vivo and in vitro functions of Sema3G in the kidney. Sema3G was expressed in glomerular podocytes. Although Sema3G knockout mice did not show obvious glomerular defects, ultrastructural analyses revealed partially aberrant podocyte foot processes structures. When these mice were injected with lipopolysaccharide to induce acute inflammation or streptozotocin to induce diabetes, the lack of Sema3G resulted in increased albuminuria. The lack of Sema3G in podocytes also enhanced the expression of inflammatory cytokines including chemokine ligand 2 and interleukin 6. On the other hand, the presence of Sema3G attenuated their expression through the inhibition of lipopolysaccharide-induced Toll like receptor 4 signaling. Taken together, our results surmise that the Sema3G protein is secreted by podocytes and protects podocytes from inflammatory kidney diseases and diabetic nephropathy. PMID:27180624

  4. APOBEC3G Interacts with ssDNA by Two Modes: AFM Studies

    NASA Astrophysics Data System (ADS)

    Shlyakhtenko, Luda S.; Dutta, Samrat; Banga, Jaspreet; Li, Ming; Harris, Reuben S.; Lyubchenko, Yuri L.

    2015-10-01

    APOBEC3G (A3G) protein has antiviral activity against HIV and other pathogenic retroviruses. A3G has two domains: a catalytic C-terminal domain (CTD) that deaminates cytidine, and a N-terminal domain (NTD) that binds to ssDNA. Although abundant information exists about the biological activities of A3G protein, the interplay between sequence specific deaminase activity and A3G binding to ssDNA remains controversial. We used the topographic imaging and force spectroscopy modalities of Atomic Force Spectroscopy (AFM) to characterize the interaction of A3G protein with deaminase specific and nonspecific ssDNA substrates. AFM imaging demonstrated that A3G has elevated affinity for deaminase specific ssDNA than for nonspecific ssDNA. AFM force spectroscopy revealed two distinct binding modes by which A3G interacts with ssDNA. One mode requires sequence specificity, as demonstrated by stronger and more stable complexes with deaminase specific ssDNA than with nonspecific ssDNA. Overall these observations enforce prior studies suggesting that both domains of A3G contribute to the sequence specific binding of ssDNA.

  5. Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions.

    PubMed

    Xu, Hongzhan; Chertova, Elena; Chen, Jianbo; Ott, David E; Roser, James D; Hu, Wei-Shau; Pathak, Vinay K

    2007-04-10

    A host cytidine deaminase, APOBEC3G (A3G), inhibits replication of human immunodeficiency virus type 1 (HIV-1) by incorporating into virions in the absence of the virally encoded Vif protein (Deltavif virions), at least in part by causing G-to-A hypermutation. To gain insight into the antiretroviral function of A3G, we determined the quantities of A3G molecules that are incorporated in Deltavif virions. We combined three experimental approaches-reversed-phase high-pressure liquid chromatography (HPLC), scintillation proximity assay (SPA), and quantitative immunoblotting-to determine the molar ratio of A3G to HIV-1 capsid protein in Deltavif virions. Our studies revealed that the amount of the A3G incorporated into Deltavif virions was proportional to the level of its expression in the viral producing cells, and the ratio of the A3G to Gag in the Deltavif virions produced from activated human peripheral blood mononuclear cells (PBMC) was approximately 1:439. Based on previous estimates of the stoichiometry of HIV-1 Gag in virions (1400-5000), we conclude that approximately 7 (+/-4) molecules of A3G are incorporated into Deltavif virions produced from human PBMCs. These results indicate that virion incorporation of only a few molecules of A3G is sufficient to inhibit HIV-1 replication. PMID:17126871

  6. Mobile telephones: a comparison of radiated power between 3G VoIP calls and 3G VoCS calls.

    PubMed

    Jovanovic, Dragan; Bragard, Guillaume; Picard, Dominique; Chauvin, Sébastien

    2015-01-01

    The purpose of this study is to assess the mean RF power radiated by mobile telephones during voice calls in 3G VoIP (Voice over Internet Protocol) using an application well known to mobile Internet users, and to compare it with the mean power radiated during voice calls in 3G VoCS (Voice over Circuit Switch) on a traditional network. Knowing that the specific absorption rate (SAR) is proportional to the mean radiated power, the user's exposure could be clearly identified at the same time. Three 3G (High Speed Packet Access) smartphones from three different manufacturers, all dual-band for GSM (900 MHz, 1800 MHz) and dual-band for UMTS (900 MHz, 1950 MHz), were used between 28 July and 04 August 2011 in Paris (France) to make 220 two-minute calls on a mobile telephone network with national coverage. The places where the calls were made were selected in such a way as to describe the whole range of usage situations of the mobile telephone. The measuring equipment, called "SYRPOM", recorded the radiation power levels and the frequency bands used during the calls with a sampling rate of 20,000 per second. In the framework of this study, the mean normalised power radiated by a telephone in 3G VoIP calls was evaluated at 0.75% maximum power of the smartphone, compared with 0.22% in 3G VoCS calls. The very low average power levels associated with use of 3G devices with VoIP or VoCS support the view that RF exposure resulting from their use is far from exceeding the basic restrictions of current exposure limits in terms of SAR. PMID:25352159

  7. International Congress of Fluid Mechanics, 3rd, Cairo, Egypt, Jan. 2-4, 1990, Proceedings. Volumes 1, 2, 3, & 4

    NASA Astrophysics Data System (ADS)

    Nayfeh, A. H.; Mobarak, A.; Rayan, M. Abou

    This conference presents papers in the fields of flow separation, unsteady aerodynamics, fluid machinery, boundary-layer control and stability, grid generation, vorticity dominated flows, and turbomachinery. Also considered are propulsion, waves and sound, rotor aerodynamics, computational fluid dynamics, Euler and Navier-Stokes equations, cavitation, mixing and shear layers, mixing layers and turbulent flows, and fluid machinery and two-phase flows. Also addressed are supersonic and reacting flows, turbulent flows, and thermofluids.

  8. [Use of imaging methods in the current screening, diagnostics and treatment of breast cancer - Professional guidelines. 3rd Breast Cancer Consensus Meeting].

    PubMed

    Forrai, Gábor; Ambrózay, Éva; Bidlek, Mária; Borbély, Katalin; Kovács, Eszter; Lengyel, Zsolt; Ormándi, Katalin; Péntek, Zoltán; Riedl, Erika; Sebõ, Éva; Szabó, Éva

    2016-09-01

    Breast radiologists and nuclear medical specialists have refreshed their previous statement text during the 3rd Hungarian Breast Cancer Consensus Meeting. They suggest taking into consideration this actual protocol for the screening, diagnostics and treatment of breast tumors, from now on. This recommendation includes the description of the newest technologies, the recent results of scientific research, as well as the role of imaging methods in the therapeutic processes and the follow-up. Suggestions for improvement of the Hungarian current practice and other related issues as forensic medicine, media connections, regulations, and reimbursement are also detailed. The statement text has been cross-checked with the related medical disciplines. PMID:27579719

  9. [Damage-loss relationships and integrated control of 3rd instar larvae of Actias selene nigpoana Felder in planting area of Cornus officinalis Sieb. et Zucc].

    PubMed

    Chen, S; Wang, C; Zhang, Q; Cheng, X

    1997-08-01

    In the present paper, the damage-loss model of Actias selene ningpoana to Cornus officinalis was tested and the results indicated that the yield loss rates obeyed the equation Y = 100 - EXP(4.6042 - 0.0315X). The economic threshold of the 2hd and 3rd instar larvae of A. selene nigpoana was then determined as 22 and 8 insects per tree respecitively. Suggestions for integrated control have been made based on the research of activities of A. selene ningpoana in the forest. PMID:11038910

  10. APOBEC3G has the ability to programme T cell plasticity.

    PubMed

    Garg, Anuradha; Kaul, Deepak

    2016-07-01

    Recently Apolipoprotein B mRNA editing enzyme, Catalytic Polypeptide-like 3G (APOBEC3G) biology has assumed importance because of its role in oncogenesis. In this context, the present study was addressed to understand the immune-modulatory role of APOBEC3G through its effect upon the T-cell plasticity phenomenon. Such an attempt revealed that APOBEC3G has the inherent capacity to regulate genes coding for STAT3, NF-κB, CCL5, IL-6, IL-4, IFN-γ, IL-10 and IL-17 coupled with downregulation of Treg cells within human peripheral blood mononuclear cells (PBMCs) without any noticeable influence upon CD4(+) and CD8(+) cell number. On the basis of these findings, we propose that APOBEC3G has the ability to induce T cell plasticity and modulate immune response. PMID:27282578

  11. Space Electrochemical Research and Technology Conference, 3rd, NASA Lewis Research Center, Cleveland, OH, Apr. 9, 10, 1991, Proceedings

    NASA Technical Reports Server (NTRS)

    Warshay, Marvin (Editor)

    1991-01-01

    The proceedings of NASA's third Space Electrochemical Research and Technology (SERT) conference are presented. The objective of the conference was to assess the present status and general thrust of research and development in those areas of electrochemical technology required to enable NASA missions in the next century. The conference provided a forum for the exchange of ideas and opinions of those actively involved in the field, in order to define new opportunities for the application of electrochemical processes in future NASA missions. Papers were presented in three technical areas: the electrochemical interface, the next generation in aerospace batteries and fuel cells, and electrochemistry for nonenergy storage applications.

  12. Atomic Force Microscopy Studies of APOBEC3G Oligomerization and Dynamics

    PubMed Central

    Shlyakhtenko, Luda S.; Lushnikov, Alexander Y.; Miyagi, Atsushi; Li, Ming; Harris, Reuben S.; Lyubchenko, Yuri L.

    2013-01-01

    The DNA cytosine deaminase APOBEC3G (A3G) is a two-domain protein that binds single-stranded DNA (ssDNA) largely through its N-terminal domain and catalyzes deamination using its C-terminal domain. A3G is considered an innate immune effector protein, with a natural capacity to block the replication of retroviruses such as HIV and retrotransposons. However, knowledge about its biophysical properties and mechanism of interaction with DNA are still limited. Oligomerization is one of these unclear issues. What is the stoichiometry of the free protein? What are the factors defining the oligomeric state of the protein? How does the protein oligomerization change upon DNA binding? How stable are protein oligomers? We address these questions here using atomic force microscopy (AFM) to directly image A3G protein in a free-state and in complexes with DNA, and using time-lapse AFM imaging to characterize the dynamics of A3G oligomers. We found that the formation of oligomers is an inherent property of A3G and that the yield of oligomers depends on the protein concentration. Oligomerization of A3G in complexes with ssDNA follows a similar pattern: the higher the protein concentrations the larger oligomers sizes. The specificity of A3G binding to ssDNA does not depend on stoichiometry. The binding of large A3G oligomers requires a longer ssDNA substrate; therefore, much smaller oligomers form complexes with short ssDNA. A3G oligomers dissociate spontaneously into monomers and this process primarily occurs through a monomer dissociation pathway. PMID:24055458

  13. 3rd Annual Earth System Grid Federation and 3rd Annual Earth System Grid Federation and Ultrascale Visualization Climate Data Analysis Tools Face-to-Face Meeting Report December 2013

    SciTech Connect

    Williams, Dean N.

    2014-02-21

    The climate and weather data science community gathered December 3–5, 2013, at Lawrence Livermore National Laboratory, in Livermore, California, for the third annual Earth System Grid Federation (ESGF) and Ultra-scale Visualization Climate Data Analysis Tools (UV-CDAT) Face-to-Face (F2F) Meeting, which was hosted by the Department of Energy, National Aeronautics and Space Administration, National Oceanic and Atmospheric Administration, the European Infrastructure for the European Network of Earth System Modelling, and the Australian Department of Education. Both ESGF and UV-CDAT are global collaborations designed to develop a new generation of open-source software infrastructure that provides distributed access and analysis to observed and simulated data from the climate and weather communities. The tools and infrastructure developed under these international multi-agency collaborations are critical to understanding extreme weather conditions and long-term climate change, while the F2F meetings help to build a stronger climate and weather data science community and stronger federated software infrastructure. The 2013 F2F meeting determined requirements for existing and impending national and international community projects; enhancements needed for data distribution, analysis, and visualization infrastructure; and standards and resources needed for better collaborations.

  14. Feasibility Study of Supercritical Light Water Cooled Fast Reactors for Actinide Burning and Electric Power Production, 3rd Quarterly Report

    SciTech Connect

    Mac Donald, Philip Elsworth

    2002-06-01

    The use of light water at supercritical pressures as the coolant in a nuclear reactor offers the potential for considerable plant simplification and consequent capital and O&M cost reduction compared with current light water reactor (LWR) designs. Also, given the thermodynamic conditions of the coolant at the core outlet (i.e. temperature and pressure beyond the water critical point), very high thermal efficiencies of the power conversion cycle are possible (i.e. up to about 45%). Because no change of phase occurs in the core, the need for steam separators and dryers as well as for BWR-type re-circulation pumps is eliminated, which, for a given reactor power, results in a substantially shorter reactor vessel and smaller containment building than the current BWRs. Furthermore, in a direct cycle the steam generators are not needed.

  15. Effect of non-erupted 3rd molars on distal roots and supporting structures of approximal teeth. A radiographic survey of 202 cases.

    PubMed

    Nemcovsky, C E; Libfeld, H; Zubery, Y

    1996-09-01

    Root resorption of 2nd molars in proximity to non-erupted 3rd molars has been widely reported. The purpose of this study was to determine the prevalence of root resorption in second molars adjacent to non-erupted third molars. Its association to age and gender of the patient, location and inclination of the non-erupted third molar and to distal bone support of the 2nd molars was analyzed. A radiographic survey of 202 periapical radiographs taken in patients with clinically missing third molars was conducted. 3 examiners independently evaluated the radiographs and only those cases where at least 2 observers agreed were included in this report. Statistical analysis was performed on 186 radiographs. Associations were analyzed with the Pearson chi 2 test. Radiographic evidence of root resorption was found in 45 2nd molars (24.2%) of which 12 (6.5%) showed moderate to complete root resorption. Non-erupted tooth apical position and mesio-inclination of 60 degrees or more relative to the distal root of the second molar were significantly associated with root resorption (p = 0.01368 and p = 0.0194, respectively). Resorption was positively associated with age of patient (p = 0.00606). These results may support early extraction of impacted 3rd molars especially in cases with a mesio-angulation of 60 degrees or more and an apical location in proximity to the distal root of the 2nd molar. PMID:8891930

  16. Development of Hg1-xCd xSe for 3rd Generation Focal Plane Arrays using Molecular Beam Epitaxy

    NASA Astrophysics Data System (ADS)

    Doyle, Kevin

    Hg1-xCd xSe grown on nearly lattice-matched GaSb substrates could serve as a new basis for infrared detector development. The preparation of the GaSb substrate surfaces and the growth of ZnTe1-xSex buffer layers via molecular beam epitaxy were investigated. ZnTe and ZnTe1- xSex layers were grown on GaSb substrates prepared with atomic hydrogen cleaning. The lattice constant of ZnTe1-xSex was tuned by controlling the ratio of Se/Te beam equivalent pressures, and ZnTe1- xSex was found to be lattice-matched to GaSb for x=0.01. Confocal photoluminescence measurements indicated that ZnTe0.99Se0.01 layers grown on GaSb have dislocation densities ˜7x104 cm-2, indicating that ZnTe0.99Se0.01/GaSb provides a high quality substrate with low dislocation densities for Hg1-xCd xSe growth. In parallel with the ZnTe1-xSe x/GaSb substrate development, the growth of Hg1- xCdxSe was studied via molecular beam epitaxy on GaSb substrates and Si substrates with ZnTe buffer layers. Growth rate, composition, and surface quality were evaluated for different growth parameters. Two sources of Se were used, an effusion cell loaded with 5N purity source material that produced a predominantly Se6 flux, and a disassociation source loaded with 6N purity source material that could produce either a predominantly Se2 or a predominantly Se6 flux. For a given substrate temperature and Hg overpressure, the growth rate was controlled by the Se flux and the x-value was controlled by the Cd/Se flux ratio. Growths under Hg-deficient conditions produced "needle" and "diamond"-shaped defects. The optimal substrate temperature was found to be 90- 110°C for growths performed with a predominantly Se 6 flux. from the effusion cell and a standard Hg flux of 2.5x10 -4 Torr. Previous studies of nominally undoped Hg1-xCd xSe samples have reported large background electron concentrations ranging from 1017-1018 cm-3 at temperatures as low as 4K. In the study reported here, the use of Se source material with 6N purity instead of 5N reduced the electron concentration in Hg1-xCdxSe by an order of magnitude, suggesting contaminants in the Se source material are a significant source of the background electrons. Certain anneals can alter the electron concentration of Hg1-xCd xSe, suggesting the presence of native point defects as well as background impurities. Positron annihilation spectroscopy measurements strongly suggest the presence of p-type mercury vacancies in Hg1- xCdxSe samples both as-grown and after annealing under an Se overpressure. Temperature-dependent Hall measurements of annealed samples suggest two donor energy levels: one in the bandgap with ionization energy of ˜40 meV that produces an electron concentration of ˜8x10 15 cm-3 at 300K, and one in the conduction band with a concentration of ˜2x1016 cm-3. The former could originate from n-type Se vacancies, while the latter is most likely impurities from the Se source material.

  17. 1st, 2nd and 3rd Generation Implementations of an eLearning Design: Re-Use from Postgraduate Law to Block/Online Engineering Course

    ERIC Educational Resources Information Center

    Lambert, Sarah; Brewer, Chris

    2007-01-01

    In order to meet the demands of postgraduate students who were time poor and unable to regularly attend face-to-face classes, one lecturer in the Faculty Law at the University of Wollongong (UOW) sought the assistance of a Learning Designer to redesign the Postgraduate Practical Legal Training (PLT) program into a flexible blended learning format,…

  18. Increased rate of depression and psychosomatic symptoms in Jewish migrants from the post-Soviet-Union to Germany in the 3rd generation after the Shoa.

    PubMed

    Ullmann, E; Barthel, A; Licinio, J; Petrowski, K; Bornstein, S R; Strauß, B

    2013-01-01

    The mental health status of persons with Jewish background living in Germany is discussed with special regard to social exclusion like anti-Semitism and overprotective parental rearing behavior, as a transmissional factor of the KZ-Syndrome. These stressors are considered in the context of a higher risk for depression/fear and psychosomatic disorders and also abnormal cortisol levels. The present sample (N=89) is derived from the Jewish population currently living in the German region of Saxony aged between 17-36 years that emigrated from the post-Soviet-Union areas. The mean age was 22.9 years. Two questionnaires to detect psychosomatic symptoms (Giessen complaint list (GBB)-24, hospital anxiety and depression scale) and one questionnaire addressing parental rearing behavior (FEE) were employed. Comparisons were drawn with normative data from the literature about the German residential population. In addition, questions were asked concerning the experience of anti-Semitism in Germany and in the post-Soviet-Union areas. A higher prevalence of depression/fear (10.3% versus 18.2%) and psychosomatic symptoms (M=14.03 versus 17.8; t=2.42; P<0.05) was observed in Jewish migrants to Germany as compared with non-Jewish German residents. Furthermore, anti-Semitic experiences in Germany correlated positively with depression (r=0.293; P<0.01) and fear (r=0.254; P<0.05). The anti-Semitic experiences in the post-Soviet-Union areas also correlated positively with limb pain (r=0.41, P<0.01), fatigue symptoms (r=0.296, P<0.01) and psychocardial symptoms (r=0.219, P<0.05). It was also confirmed that the male respondents recalled a controlling and overprotecting maternal rearing behavior more frequently than the German standard random sample (M=15.39 versus 18.6; t=2.68; P<0.01). The latter also correlated significantly positive with epigastric pain (r=0.349; P<0.01). The present results show that depression, fear and psychosomatic problems are common in Jewish residents with a background of migration from the post-Soviet-Union areas to Germany. Apart from the transgenerational passing of psychological traumata and the Holocaust experiences, other stressors like anti-Semitism, control and overprotection as parental rearing measures appear to be important factors specifically contributing to the pathogenesis of the attributed symptoms. PMID:23481628

  19. Real Time In Situ Observations of Equiaxed Dendrite Coherency in Al-Cu Alloys Using High-Brilliance, 3rd Generation Synchrotron Sources

    NASA Technical Reports Server (NTRS)

    Murphy, Andrew G.; Browne, David J.; Mirihanage, Wajira U.; Mathiesen, Ragnvald H.

    2012-01-01

    In the last decade synchrotron X-ray sources have fast become the tool of choice for performing in-situ high resolution imaging during alloy solidification. This paper presents the results of an experimental campaign carried out at the European Synchrotron Radiation Facility, using a Bridgman furnace, to monitor phenomena during solidification of Al-Cu alloys - specifically the onset of equiaxed dendrite coherency. Conventional experimental methods for determining coherency involve measuring the change in viscosity or measuring the change in thermal conductivity across the solidifying melt Conflicts arise when comparing the results of these experimental techniques to find a relationship between cooling rate and coherency fraction. It has been shown that the ratio of average velocity to the average grain diameter has an inversely proportional relationship to coherency fraction. In-situ observation therefore makes it possible to measure these values directly from acquired images sequences and make comparisons with published results.

  20. Analysis of Salmonella enterica with reduced susceptibility to the 3rd generation cephalosporin, ceftriaxone, isolated from US cattle during 2000-2004

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Over the past decade enteric bacteria in Europe, Africa and Asia have become increasingly resistant to cephalosporin antimicrobials. This is largely due to the spread of genes encoding extended-spectrum ß-lactamase (ESBL) enzymes which can inactivate many cephalosporins. Recently these resistance me...

  1. D Modeling of Headstones of the 2ND and 3RD Century by Low Cost Photogrammetric Techniques

    NASA Astrophysics Data System (ADS)

    Landes, T.; Waton, M.-D.; Alby, E.; Gourvez, S.; Lopes, B.

    2013-07-01

    As a dozen headstones have been discovered during excavations in south Alsace, archaeologists stored them in the Regional Directorate of Cultural Affairs in Strasbourg. In order to complete the survey they are used to practice by hand on the steles, they asked the INSA Strasbourg to reconstruct at least the 7 figured sandstones in 3D. The high accuracy required by the archaeologists can be reached by an expensive technique using laserscanning system. Aim of the current work is to look for an alternative method and (if appropriate) low cost software allowing to provide a similar quality and a sufficient level of details. The 3D reconstruction of the headstones based exclusively on multiple images processing is presented. The step of point cloud generation is detailed because it determines the final product quality. Therefore, an assessment of the produced point cloud has been performed through comparison to a reference point cloud obtained by laser scanning technique. The steps leading to the photo-realistic textured 3D models of the headstones are presented and the software used for that are evaluated. The final product respects the accuracy requirement of 1 mm desired by the archaeologists.

  2. Inactivation of yeast hexokinase by Cibacron Blue 3G-A: spectral, kinetic and structural investigations.

    PubMed Central

    Puri, R N; Roskoski, R

    1994-01-01

    Yeast hexokinase, a homodimer (100 kDa), is an important enzyme in the glycolytic pathway. Although Cibacron Blue 3G-A (Reactive Blue 2) has been previously shown to inactivate yeast hexokinase, no comprehensive study exists concerning the nature of interaction(s) between hexokinase and the blue dye. A comparison of the computer-generated three-dimensional (3D) representations showed considerable overlap of the purine ring of ATP, a nucleotide substrate of hexokinase, with the hydrophobic anthraquinone moiety of the blue dye. The visible spectrum of the blue dye showed a characteristic absorption band centred at 628 nm. The visible difference spectrum of increasing concentration of the dye and the same concentrations of the dye plus a fixed concentration of hexokinase exhibited a maximum, a minimum and an isobestic point at 683, 585, and 655 nm respectively. The visible difference spectrum of the blue dye and the dye in 50% ethylene glycol showed a maximum and a minimum at 660 and 570 nm respectively. The visible difference spectrum of the blue dye in the presence of the dye and hexokinase modified at the active site by pyridoxal phosphate, iodoacetamide and o-phthalaldehyde was devoid of bands characteristic of the hexokinase-blue dye complex. Size-exclusion-chromatographic studies in the absence or presence of guanidinium chloride showed that the enzyme inactivated by the blue dye was co-eluted with the unmodified enzyme. The dialysis residue obtained after extensive dialysis of the gel-filtered complex, against a buffer of high ionic strength, showed an absorption maximum at 655 nm characteristic of the dye-enzyme complex. Inactivation data when analysed by 'Kitz-Wilson'-type kinetics for an irreversible inhibitor, yielded values of 0.05 min-1 and 92 microM for maximum rate of inactivation (k3) and dissociation constant (Kd) for the enzyme-dye complex respectively. Sugar and nucleotide substrates protected hexokinase against inactivation by the blue dye. About 2

  3. The 2100MHz radiofrequency radiation of a 3G-mobile phone and the DNA oxidative damage in brain.

    PubMed

    Sahin, Duygu; Ozgur, Elcin; Guler, Goknur; Tomruk, Arın; Unlu, Ilhan; Sepici-Dinçel, Aylin; Seyhan, Nesrin

    2016-09-01

    We aimed to evaluate the effect of 2100MHz radiofrequency radiation emitted by a generator, simulating a 3G-mobile phone on the brain of rats during 10 and 40 days of exposure. The female rats were randomly divided into four groups. Group I; exposed to 3G modulated 2100MHz RFR signal for 6h/day, 5 consecutive days/wk for 2 weeks, group II; control 10 days, were kept in an inactive exposure set-up for 6h/day, 5 consecutive days/wk for 2 weeks, group III; exposed to 3G modulated 2100MHz RFR signal for 6h/day, 5 consecutive days/wk for 8 weeks and group IV; control 40 days, were kept in an inactive exposure set-up for 6h/day, 5 consecutive days/wk for 8 weeks. After the genomic DNA content of brain was extracted, oxidative DNA damage (8-hydroxy-2'deoxyguanosine, pg/mL) and malondialdehyde (MDA, nmoL/g tissue) levels were determined. Our main finding was the increased oxidative DNA damage to brain after 10 days of exposure with the decreased oxidative DNA damage following 40 days of exposure compared to their control groups. Besides decreased lipid peroxidation end product, MDA, was observed after 40 days of exposure. The measured decreased quantities of damage during the 40 days of exposure could be the means of adapted and increased DNA repair mechanisms. PMID:26775761

  4. Conformational distribution of baclofen analogues by 1H and 13C NMR analysis and ab initio HF MO STO-3G or STO-3G* calculations

    NASA Astrophysics Data System (ADS)

    Vaccher, Claude; Berthelot, Pascal; Debaert, Michel; Vermeersch, Gaston; Guyon, René; Pirard, Bernard; Vercauteren, Daniel P.; Dory, Magdalena; Evrard, Guy; Durant, François

    1993-12-01

    The conformations of 3-(substituted furan-2-yl) and 3-(substituted thien-2-yl)-γ-aminobutyric acid 1-9 in solution (D 2O) are estimated from high-resolution (300 MHz) 1H NMR coupling data. Conformations and populations of conformers are calculated by means of a modified Karplus-like relationship for the vicinal coupling constants. The results are compared with X-ray crystallographic investigations (torsion angles) and ab initio HF MO ST-3G or STO-3G* calculations. 1H NMR spectral analysis shows how 1-9 in solution retain the preferred g- conformation around the C3C4 bond, as found in the solid state, while a partial rotation is set up around the C2C3 bond: the conformations about C2C3 are all highly populated in solution. The 13C spin-lattice relaxation times are also discussed.

  5. Exposure assessment of one-year-old child to 3G tablet in uplink mode and to 3G femtocell in downlink mode using polynomial chaos decomposition

    NASA Astrophysics Data System (ADS)

    Liorni, I.; Parazzini, M.; Varsier, N.; Hadjem, A.; Ravazzani, P.; Wiart, J.

    2016-04-01

    So far, the assessment of the exposure of children, in the ages 0-2 years old, to relatively new radio-frequency (RF) technologies, such as tablets and femtocells, remains an open issue. This study aims to analyse the exposure of a one year-old child to these two sources, tablets and femtocells, operating in uplink (tablet) and downlink (femtocell) modes, respectively. In detail, a realistic model of an infant has been used to model separately the exposures due to (i) a 3G tablet emitting at the frequency of 1940 MHz (uplink mode) placed close to the body and (ii) a 3G femtocell emitting at 2100 MHz (downlink mode) placed at a distance of at least 1 m from the infant body. For both RF sources, the input power was set to 250 mW. The variability of the exposure due to the variation of the position of the RF sources with respect to the infant body has been studied by stochastic dosimetry, based on polynomial chaos to build surrogate models of both whole-body and tissue specific absorption rate (SAR), which makes it easy and quick to investigate the exposure in a full range of possible positions of the sources. The major outcomes of the study are: (1) the maximum values of the whole-body SAR (WB SAR) have been found to be 9.5 mW kg-1 in uplink mode and 65 μW kg-1 in downlink mode, i.e. within the limits of the ICNIRP 1998 Guidelines; (2) in both uplink and downlink mode the highest SAR values were approximately found in the same tissues, i.e. in the skin, eye and penis for the whole-tissue SAR and in the bone, skin and muscle for the peak SAR; (3) the change in the position of both the 3G tablet and the 3G femtocell significantly influences the infant exposure.

  6. Exposure assessment of one-year-old child to 3G tablet in uplink mode and to 3G femtocell in downlink mode using polynomial chaos decomposition.

    PubMed

    Liorni, I; Parazzini, M; Varsier, N; Hadjem, A; Ravazzani, P; Wiart, J

    2016-04-21

    So far, the assessment of the exposure of children, in the ages 0-2 years old, to relatively new radio-frequency (RF) technologies, such as tablets and femtocells, remains an open issue. This study aims to analyse the exposure of a one year-old child to these two sources, tablets and femtocells, operating in uplink (tablet) and downlink (femtocell) modes, respectively. In detail, a realistic model of an infant has been used to model separately the exposures due to (i) a 3G tablet emitting at the frequency of 1940 MHz (uplink mode) placed close to the body and (ii) a 3G femtocell emitting at 2100 MHz (downlink mode) placed at a distance of at least 1 m from the infant body. For both RF sources, the input power was set to 250 mW. The variability of the exposure due to the variation of the position of the RF sources with respect to the infant body has been studied by stochastic dosimetry, based on polynomial chaos to build surrogate models of both whole-body and tissue specific absorption rate (SAR), which makes it easy and quick to investigate the exposure in a full range of possible positions of the sources. The major outcomes of the study are: (1) the maximum values of the whole-body SAR (WB SAR) have been found to be 9.5 mW kg(-1) in uplink mode and 65 μW kg(-1) in downlink mode, i.e. within the limits of the ICNIRP 1998 Guidelines; (2) in both uplink and downlink mode the highest SAR values were approximately found in the same tissues, i.e. in the skin, eye and penis for the whole-tissue SAR and in the bone, skin and muscle for the peak SAR; (3) the change in the position of both the 3G tablet and the 3G femtocell significantly influences the infant exposure. PMID:27027265

  7. At3g08030 transcript: a molecular marker of seed ageing

    PubMed Central

    Garza-Caligaris, Luz Elena; Avendaño-Vázquez, Aida Odette; Alvarado-López, Sandra; Zúñiga-Sánchez, Esther; Orozco-Segovia, Alma; Pérez-Ruíz, Rigoberto V.; Gamboa-deBuen, Alicia

    2012-01-01

    Background and Aims Prolonged storage generally reduces seed viability and vigour, although the rate of deterioration varies among species and environmental conditions. Here, we suggest a possible ageing molecular marker: At3g08030 mRNA. At3g08030 is a member of the DUF642 highly conserved family of cell-wall-associated proteins that is specific for spermatophytes. Methods At3g08030 expression was performed by RT-PCR and qRT-PCR analysis in seed samples differing in their rate of germination and final germination following a matrix priming and/or controlled deterioration (rapid ageing) treatment. Key Results The At3g08030 gene transcript was present during the entire Arabidopsis thaliana plant life cycle and in seeds, during maturation, the ripening period and after germination. Matrix priming treatment increased the rate of germination of control seeds and seeds aged by controlled deterioration. Priming treatments also increased At3g08030 expression. To determine whether the orthologues of this gene are also age markers in other plant species, At3g08030 was cloned in two wild species, Ceiba aesculifolia and Wigandia urens. As in A. thaliana, the At3g08030 transcript was not present in aged seeds of the tested species but was present in recently shed seeds. A reduction in germination performance of the aged seeds under salt stress was determined by germination assays. Conclusions At3g08030 mRNA detection in a dry seed lot has potential for use as a molecular marker for germination performance in a variety of plant species. PMID:22975286

  8. Oral immunization of mice with recombinant rabies vaccine strain (ERAG3G) induces complete protection

    PubMed Central

    2015-01-01

    Purpose New rabies vaccine bait for both pets and raccoon dogs residing in Korea is needed to eradicate rabies infection among animals. In this study, we constructed a recombinant rabies virus (RABV), the ERAG3G strain, using a reverse genetics system. Then we investigated the efficacy of this strain in mice after oral administration and the safety of this strain in cats after intramuscular administration. Materials and Methods The ERAG3G strain was rescued in BHK/T7-9 cells using the full-length genome mutated at the amino acid position 333 of the glycoprotein gene of RABV and helper plasmids. Four-week-old mice underwent one or two oral administrations of the ERAG3G strain and were challenged with the highly virulent RABV strain CVSN2c 14 days after the second administration. Clinical symptoms were observed and body weights were measured every day after the challenge. Results All mice showed complete protection against virulent RABV. In addition, cats intramuscularly inoculated with the ERAG3G strain showed high antibody titers ranging from 2.62 to 23.9 IU/mL at 28-day postinoculation. Conclusion The oral immunization of the ERAG3G strain plays an important role in conferring complete protection in mice, and intramuscular inoculation of the ERAG3G strain induces the formation of anti-rabies neutralizing antibody in cats. PMID:25648184

  9. HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation

    PubMed Central

    Mercenne, Gaëlle; Bernacchi, Serena; Richer, Delphine; Bec, Guillaume; Henriet, Simon; Paillart, Jean-Christophe; Marquet, Roland

    2010-01-01

    The HIV-1 viral infectivity factor (Vif) allows productive infection of non-permissive cells (including most natural HIV-1 targets) by counteracting the cellular cytosine deaminases APOBEC-3G (hA3G) and hA3F. The Vif-induced degradation of these restriction factors by the proteasome has been extensively studied, but little is known about the translational repression of hA3G and hA3F by Vif, which has also been proposed to participate in Vif function. Here, we studied Vif binding to hA3G mRNA and its role in translational repression. Filter binding assays and fluorescence titration curves revealed that Vif tightly binds to hA3G mRNA. Vif overall binding affinity was higher for the 3′UTR than for the 5′UTR, even though this region contained at least one high affinity Vif binding site (apparent Kd = 27 ± 6 nM). Several Vif binding sites were identified in 5′ and 3′UTRs using RNase footprinting. In vitro translation evidenced that Vif inhibited hA3G translation by two mechanisms: a main time-independent process requiring the 5′UTR and an additional time-dependent, UTR-independent process. Results using a Vif protein mutated in the multimerization domain suggested that the molecular mechanism of translational control is more complicated than a simple physical blockage of scanning ribosomes. PMID:19910370

  10. HIV-1 Vif binds to APOBEC3G mRNA and inhibits its translation.

    PubMed

    Mercenne, Gaëlle; Bernacchi, Serena; Richer, Delphine; Bec, Guillaume; Henriet, Simon; Paillart, Jean-Christophe; Marquet, Roland

    2010-01-01

    The HIV-1 viral infectivity factor (Vif) allows productive infection of non-permissive cells (including most natural HIV-1 targets) by counteracting the cellular cytosine deaminases APOBEC-3G (hA3G) and hA3F. The Vif-induced degradation of these restriction factors by the proteasome has been extensively studied, but little is known about the translational repression of hA3G and hA3F by Vif, which has also been proposed to participate in Vif function. Here, we studied Vif binding to hA3G mRNA and its role in translational repression. Filter binding assays and fluorescence titration curves revealed that Vif tightly binds to hA3G mRNA. Vif overall binding affinity was higher for the 3'UTR than for the 5'UTR, even though this region contained at least one high affinity Vif binding site (apparent K(d) = 27 +/- 6 nM). Several Vif binding sites were identified in 5' and 3'UTRs using RNase footprinting. In vitro translation evidenced that Vif inhibited hA3G translation by two mechanisms: a main time-independent process requiring the 5'UTR and an additional time-dependent, UTR-independent process. Results using a Vif protein mutated in the multimerization domain suggested that the molecular mechanism of translational control is more complicated than a simple physical blockage of scanning ribosomes. PMID:19910370

  11. Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

    SciTech Connect

    Holden, Lauren G.; Prochnow, Courtney; Chang, Y. Paul; Bransteitter, Ronda; Chelico, Linda; Sen, Udayaditya; Stevens, Raymond C.; Goodman, Myron F.; Chen, Xiaojiang S.

    2009-04-07

    The APOBEC family members are involved in diverse biological functions. APOBEC3G restricts the replication of human immunodeficiency virus (HIV), hepatitis B virus and retroelements by cytidine deamination on single-stranded DNA or by RNA binding. Here we report the high-resolution crystal structure of the carboxy-terminal deaminase domain of APOBEC3G (APOBEC3G-CD2) purified from Escherichia coli. The APOBEC3G-CD2 structure has a five-stranded {beta}-sheet core that is common to all known deaminase structures and closely resembles the structure of another APOBEC protein, APOBEC2. A comparison of APOBEC3G-CD2 with other deaminase structures shows a structural conservation of the active-site loops that are directly involved in substrate binding. In the X-ray structure, these APOBEC3G active-site loops form a continuous 'substrate groove' around the active centre. The orientation of this putative substrate groove differs markedly (by 90 degrees) from the groove predicted by the NMR structure. We have introduced mutations around the groove, and have identified residues involved in substrate specificity, single-stranded DNA binding and deaminase activity. These results provide a basis for understanding the underlying mechanisms of substrate specificity for the APOBEC family.

  12. Deuterium beam acceleration with 3rd harmonic ion cyclotron resonance heating in Joint European Torus: Sawtooth stabilization and Alfvén eigenmodes

    NASA Astrophysics Data System (ADS)

    Gassner, T.; Schoepf, K.; Sharapov, S. E.; Kiptily, V. G.; Pinches, S. D.; Hellesen, C.; Eriksson, J.; JET-EFDA contributors

    2012-03-01

    Experiments on accelerating NBI-produced deuterium (D) beam ions from their injection energy of ˜110 keV up to the MeV energy range with 3rd harmonic ion cyclotron resonance heating were performed on the Joint European Torus [P. H. Rebut and B. E. Keen, Fusion Technol. 11, 13 (1987)]. A renewed set of nuclear diagnostics was used for analysing fast D ions during sawtooth stabilization, monster sawtooth crashes, and during excitation of Alfvén eigenmodes (AEs) residing inside the q = 1 radius. The measurements and modeling of the fast ions with the nonlinear HAGIS code [S. D. Pinches et al., Comput. Phys. Commun. 111, 133 (1998)] show that monster sawtooth crashes are strongly facilitated by the AE-induced re-distribution of the fast D ions from inside the q = 1 radius to the plasma edge.

  13. [Pathological diagnosis, work-up and reporting of breast cancer. Recommendations of the 3rd Hungarian Consensus Conference on Breast Cancer].

    PubMed

    Cserni, Gábor; Kulka, Janina; Francz, Monika; Járay, Balázs; Kálmán, Endre; Kovács, Ilona; Krenács, Tibor; Udvarhelyi, Nóra; Vass, László

    2016-09-01

    There have been relevant changes in the diagnosis and treatment of breast cancer to implement the updating of the 2010 recommendations made during the 2nd national consensus conference on the disease. Following a wide interdisciplinary consultation, the present recommendations have been finalized after their public discussion at the 3rd Hungarian Consensus Conference on Breast Cancer. The recommendations cover non-operative and intraoperative diagnostics, the work-up of operative specimens, the determination of prognostic and predictive markers and the content of the cytology and histology reports. Furthermore, it touches some special issues such as the current status of multigene molecular markers, the role of pathologists in clinical trials and prerequisites for their involvement, some relevant points about the future. PMID:27579721

  14. From challenges to solutions. European Bioanalysis Forum 3rd Annual Open Symposium, Hesperia Towers, Barcelona, Spain, 1-3 December 2010.

    PubMed

    Abbott, Richard W; Gordon, Ben; van Amsterdam, Peter; Lausecker, Berthold; Brudny-Kloeppel, Margarete; Smeraglia, John; Romero, Fernando; Globig, Susanne; Golob, Michaela; Knutsson, Magnus; Herling, Christian; Vieser, Eva; Timmerman, Philip

    2011-04-01

    The European Bioanalysis Forum is a bioanalytical nonprofit organization comprised of European pharmaceutical companies (27 members to date) and currently expanding to include CROs as well. The European Bioanalysis Forum provides a broad European bioanalytical network for the discussion of scientific, technological and regulatory topics of bioanalytical interest. The 3rd Annual Open Symposium was again much anticipated after the two previous successful meetings. The symposium included sessions on thinking outside the 'commodity' box, bioanalytical challenges with blood, global harmonization, assay platforms, dried blood spots, immunogenicity, matrix effects, anomalous results, biomarkers and two plenary technology sessions hosted by the Platinum sponsors. Experts and key opinion leaders were invited as guest speakers. A total of 424 delegates registered from 113 companies representing a large percentage of the European bioanalytical community. In addition to 48 oral presentations, 88 posters were presented and there was a vendor exposition of 40 companies. PMID:21510756

  15. Reflections: Surgical Education-the Times they are a-Changin': Lessons Learned from the 3rd MAYMET-ESO Joint Meeting.

    PubMed

    Tarkowski, Radoslaw; Vetto, John T

    2015-09-01

    Technical skills are not sufficient for successful surgical care. Non-technical skills such as team work, decision-making in cancer treatment, communication with the patient, ethical challenges, situation awareness, and communication in the operating room are mandatory for favorable outcomes. Although formally taught in other high-demand disciplines, such skills were traditionally rarely discussed in surgical oncology. The 3rd MAYMET-ESO Joint Meeting "Professionalism for Breast Surgeons" held in Istanbul, Turkey, 5 October 2013 was dedicated to the development of non-technical skills in the everyday activity of breast surgeons. We briefly discuss information from this very interesting and inspiring educational event and how it relates to more recent changes in surgical oncology education. PMID:25903052

  16. Adaptive and Effortful Control and Academic Self-efficacy Beliefs on Achievement: A Longitudinal Study of 1st through 3rd Graders

    PubMed Central

    Liew, Jeffrey; McTigue, Erin; Barrois, Lisa; Hughes, Jan

    2009-01-01

    The linkages between self-regulatory processes and achievement were examined across three years in 733 children beginning at 1st grade (M = 6.57 years, SD = .39 at 1st grade) who were identified as lower achieving in literacy. Accounting for consistencies in measures (from one year prior) and for influences of child’s age, gender, IQ, ethnicity and economic adversity on achievement, results indicate that adaptive/effortful control at 1st grade contributed to both academic self-efficacy beliefs at 2nd grade, and reading (but not math) achievement at 3rd grade. Although academic self-efficacy did not partially mediate the linkage between adaptive/effortful control and achievement, academic self-efficacy beliefs were positively correlated with reading and math. Results support the notion that early efforts to promote children’s self-regulatory skills would enhance future academic self-beliefs and achievement, particularly in literacy. PMID:19169387

  17. Limbic system development underlies the emergence of classical fear conditioning during the 3rd and 4th weeks of life in the rat

    PubMed Central

    Deal, Alex L.; Erickson, Kristen J.; Shiers, Stephanie I.; Burman, Michael A.

    2016-01-01

    Classical fear conditioning creates an association between an aversive stimulus and a neutral stimulus. Although the requisite neural circuitry is well understood in mature organisms, the development of these circuits is less well studied. The current experiments examine the ontogeny of fear conditioning and relate it to neuronal activation assessed through immediate early gene (IEG) expression in the amygdala, hippocampus, perirhinal cortex, and hypothalamus of periweanling rats. Rat pups were fear conditioned, or not, during the 3rd or 4th weeks of life. Neuronal activation was assessed by quantifying expression of FBJ osteosarcoma oncogene (FOS) using immunohistochemistry (IHC) in Experiment 1. Fos and early growth response gene-1 (EGR1) expression was assessed using qRT-PCR in Experiment 2. Behavioral data confirm that both auditory and contextual fear continue to emerge between PD 17 and 24. The IEG expression data are highly consistent with these behavioral results. IHC results demonstrate significantly more FOS protein expression in the basal amygdala of fear conditioned PD 23 subjects compared to control subjects, but no significant difference at PD 17. qRT-PCR results suggest specific activation of the amygdala only in older subjects during auditory fear expression. A similar effect of age and conditioning status was also observed in the perirhinal cortex during both contextual and auditory fear expression. Overall, the development of fear conditioning occurring between the 3rd and 4th weeks of life appears to be at least partly attributable to changes in activation of the amygdala and perirhinal cortex during fear conditioning or expression. PMID:26820587

  18. APOBEC3G impairs the multimerization of the HIV-1 Vif protein in living cells.

    PubMed

    Batisse, Julien; Guerrero, Santiago Xavier; Bernacchi, Serena; Richert, Ludovic; Godet, Julien; Goldschmidt, Valérie; Mély, Yves; Marquet, Roland; de Rocquigny, Hugues; Paillart, Jean-Christophe

    2013-06-01

    The HIV-1 viral infectivity factor (Vif) is a small basic protein essential for viral fitness and pathogenicity. Vif allows productive infection in nonpermissive cells, including most natural HIV-1 target cells, by counteracting the cellular cytosine deaminases APOBEC3G (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G [A3G]) and A3F. Vif is also associated with the viral assembly complex and packaged into viral particles through interactions with the viral genomic RNA and the nucleocapsid domain of Pr55(Gag). Recently, we showed that oligomerization of Vif into high-molecular-mass complexes induces Vif folding and influences its binding to high-affinity RNA binding sites present in the HIV genomic RNA. To get further insight into the role of Vif multimerization in viral assembly and A3G repression, we used fluorescence lifetime imaging microscopy (FLIM)- and fluorescence resonance energy transfer (FRET)-based assays to investigate Vif-Vif interactions in living cells. By using two N-terminally tagged Vif proteins, we show that Vif-Vif interactions occur in living cells. This oligomerization is strongly reduced when the putative Vif multimerization domain ((161)PPLP(164)) is mutated, indicating that this domain is crucial, but that regions outside this motif also participate in Vif oligomerization. When coexpressed together with Pr55(Gag), Vif is largely relocated to the cell membrane, where Vif oligomerization also occurs. Interestingly, wild-type A3G strongly interferes with Vif multimerization, contrary to an A3G mutant that does not bind to Vif. These findings confirm that Vif oligomerization occurs in living cells partly through its C-terminal motif and suggest that A3G may target and perturb the Vif oligomerization state to limit its functions in the cell. PMID:23576497

  19. APOBEC3G Impairs the Multimerization of the HIV-1 Vif Protein in Living Cells

    PubMed Central

    Batisse, Julien; Guerrero, Santiago Xavier; Bernacchi, Serena; Richert, Ludovic; Godet, Julien; Goldschmidt, Valérie; Mély, Yves; Marquet, Roland; de Rocquigny, Hugues

    2013-01-01

    The HIV-1 viral infectivity factor (Vif) is a small basic protein essential for viral fitness and pathogenicity. Vif allows productive infection in nonpermissive cells, including most natural HIV-1 target cells, by counteracting the cellular cytosine deaminases APOBEC3G (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G [A3G]) and A3F. Vif is also associated with the viral assembly complex and packaged into viral particles through interactions with the viral genomic RNA and the nucleocapsid domain of Pr55Gag. Recently, we showed that oligomerization of Vif into high-molecular-mass complexes induces Vif folding and influences its binding to high-affinity RNA binding sites present in the HIV genomic RNA. To get further insight into the role of Vif multimerization in viral assembly and A3G repression, we used fluorescence lifetime imaging microscopy (FLIM)- and fluorescence resonance energy transfer (FRET)-based assays to investigate Vif-Vif interactions in living cells. By using two N-terminally tagged Vif proteins, we show that Vif-Vif interactions occur in living cells. This oligomerization is strongly reduced when the putative Vif multimerization domain (161PPLP164) is mutated, indicating that this domain is crucial, but that regions outside this motif also participate in Vif oligomerization. When coexpressed together with Pr55Gag, Vif is largely relocated to the cell membrane, where Vif oligomerization also occurs. Interestingly, wild-type A3G strongly interferes with Vif multimerization, contrary to an A3G mutant that does not bind to Vif. These findings confirm that Vif oligomerization occurs in living cells partly through its C-terminal motif and suggest that A3G may target and perturb the Vif oligomerization state to limit its functions in the cell. PMID:23576497

  20. Veterinary Microbiology, 3rd Edition

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Veterinary Microbiology, Third Edition is organized into four sections and begins with an updated and expanded introductory section on infectious disease pathogenesis, diagnosis and clinical management. The second section covers bacterial and fungal pathogens, and the third section describes viral d...

  1. Landman's encyclopedia. 3rd edition

    SciTech Connect

    Hankinson, R.L.; Hankinson, R.L. Jr.

    1987-01-01

    This book discusses the guidelines for petroleum landmen and includes the new documents: partial assignment of oil, gas, and mineral lease, net profits agreement, net profit interest, ratification agreements, an additional farmout agreement form, gas balancing agreement, shut-in gas royalty, oil, gas, and mineral lease form (Exxon lease), extension agreement, Pugh clause, assignment form of lease and equipment, losses addendum for operating agreements, boundary agreement, change of lease description forms. Also included is a cross-listing of the document numbers used in this book with those used in the popular software database.

  2. Human APOBEC3G drives HIV-1 evolution and the development of drug resistance

    SciTech Connect

    Bhattacharya, Tamoy; Kim, Eun - Young; Koning, Fransje; Malim, Michael; Wolinsky, Steven M

    2008-01-01

    Human APOBEC3G (hA3G) is an innate virus restriction factor that induces deamination of specific cytidine residues in single-stranded human immunodeficiency virus type 1 (HIV-1) DNA. Whereas destructive hA3G editing leads to a profound loss of HIV-1 infectivity, more limited editing could be a source of adaptation and diversification. Here we show that the presence of hA3G in T-cells can drive the development of diversity in HIV-1 populations and that under selection pressure imposed by the nucleotide analog reverse transcriptase inhibitor 3TC ((-)2',3'-dideoxy-3'-thiacytidine), a single point mutation that confers 3TC resistance, methionine 184 to isoleucine (M1841), emerges rapidly and reaches fixation. These results provide strong evidence that mutation by hA3G is an important source of genetic variation on which natural selection acts to shape the structure of the viral population and drive the tempo of HIV-1 evolution.

  3. An Experimental Performance Comparison of 3G and Wi-Fi

    NASA Astrophysics Data System (ADS)

    Gass, Richard; Diot, Christophe

    Mobile Internet users have two options for connectivity: pay premium fees to utilize 3G or wander around looking for open Wi-Fi access points. We perform an experimental evaluation of the amount of data that can be pushed to and pulled from the Internet on 3G and open Wi-Fi access points while on the move. This side-by-side comparison is carried out at both driving and walking speeds in an urban area using standard devices. We show that significant amounts of data can be transferred opportunistically without the need of always being connected to the network. We also show that Wi-Fi mostly suffers from not being able to exploit short contacts with access points but performs comparably well against 3G when downloading and even significantly better while uploading data.

  4. Gene duplication and neofunctionalization: POLR3G and POLR3GL

    PubMed Central

    Renaud, Marianne; Praz, Viviane; Vieu, Erwann; Florens, Laurence; Washburn, Michael P.; l'Hôte, Philippe; Hernandez, Nouria

    2014-01-01

    RNA polymerase III (Pol III) occurs in two versions, one containing the POLR3G subunit and the other the closely related POLR3GL subunit. It is not clear whether these two Pol III forms have the same function, in particular whether they recognize the same target genes. We show that the POLR3G and POLR3GL genes arose from a DNA-based gene duplication, probably in a common ancestor of vertebrates. POLR3G- as well as POLR3GL-containing Pol III are present in cultured cell lines and in normal mouse liver, although the relative amounts of the two forms vary, with the POLR3G-containing Pol III relatively more abundant in dividing cells. Genome-wide chromatin immunoprecipitations followed by high-throughput sequencing (ChIP-seq) reveal that both forms of Pol III occupy the same target genes, in very constant proportions within one cell line, suggesting that the two forms of Pol III have a similar function with regard to specificity for target genes. In contrast, the POLR3G promoter—not the POLR3GL promoter—binds the transcription factor MYC, as do all other promoters of genes encoding Pol III subunits. Thus, the POLR3G/POLR3GL duplication did not lead to neo-functionalization of the gene product (at least with regard to target gene specificity) but rather to neo-functionalization of the transcription units, which acquired different mechanisms of regulation, thus likely affording greater regulation potential to the cell. PMID:24107381

  5. A Kinesthetic Learning Approach to Earth Science for 3rd and 4th Grade Students on the Pajarito Plateau, Los Alamos, NM

    NASA Astrophysics Data System (ADS)

    Wershow, H. N.; Green, M.; Stocker, A.; Staires, D.

    2010-12-01

    Current efforts towards Earth Science literacy in New Mexico are guided by the New Mexico Science Benchmarks [1]. We are geoscience professionals in Los Alamos, NM who believe there is an important role for non-traditional educators utilizing innovative teaching methods. We propose to further Earth Science literacy for local 3rd and 4th grade students using a kinesthetic learning approach, with the goal of fostering an interactive relationship between the students and their geologic environment. We will be working in partnership with the Pajarito Environmental Education Center (PEEC), which teaches the natural heritage of the Pajarito Plateau to 3rd and 4th grade students from the surrounding area, as well as the Family YMCA’s Adventure Programs Director. The Pajarito Plateau provides a remarkable geologic classroom because minimal structural features complicate the stratigraphy and dramatic volcanic and erosional processes are plainly on display and easily accessible. Our methodology consists of two approaches. First, we will build an interpretive display of the local geology at PEEC that will highlight prominent rock formations and geologic processes seen on a daily basis. It will include a simplified stratigraphic section with field specimens and a map linked to each specimen’s location to encourage further exploration. Second, we will develop and implement a kinesthetic curriculum for an exploratory field class. Active engagement with geologic phenomena will take place in many forms, such as a scavenger hunt for precipitated crystals in the vesicles of basalt flows and a search for progressively smaller rhyodacite clasts scattered along an actively eroding canyon. We believe students will be more receptive to origin explanations when they possess a piece of the story. Students will be provided with field books to make drawings of geologic features. This will encourage independent assessment of phenomena and introduce the skill of scientific observation. We

  6. Mapping the Vif-A3G interaction using peptide arrays: a basis for anti-HIV lead peptides.

    PubMed

    Reingewertz, Tali H; Britan-Rosich, Elena; Rotem-Bamberger, Shahar; Viard, Mathias; Jacobs, Amy; Miller, Abigail; Lee, Ji Youn; Hwang, Jeeseong; Blumenthal, Robert; Kotler, Moshe; Friedler, Assaf

    2013-06-15

    Human apolipoprotein-B mRNA-editing catalytic polypeptide-like 3G (A3G) is a cytidine deaminase that restricts retroviruses, endogenous retro-elements and DNA viruses. A3G plays a key role in the anti-HIV-1 innate cellular immunity. The HIV-1 Vif protein counteracts A3G mainly by leading A3G towards the proteosomal machinery and by direct inhibition of its enzymatic activity. Both activities involve direct interaction between Vif and A3G. Disrupting the interaction between A3G and Vif may rescue A3G antiviral activity and inhibit HIV-1 propagation. Here, mapping the interaction sites between A3G and Vif by peptide array screening revealed distinct regions in Vif important for A3G binding, including the N-terminal domain (NTD), C-terminal domain (CTD) and residues 83-99. The Vif-binding sites in A3G included 12 different peptides that showed strong binding to either full-length Vif, Vif CTD or both. Sequence similarity was found between Vif-binding peptides from the A3G CTD and NTD. A3G peptides were synthesized and tested for their ability to counteract Vif action. A3G 211-225 inhibited HIV-1 replication in cell culture and impaired Vif dependent A3G degradation. In vivo co-localization of full-length Vif with A3G 211-225 was demonstrated by use of FRET. This peptide has the potential to serve as an anti-HIV-1 lead compound. Our results suggest a complex interaction between Vif and A3G that is mediated by discontinuous binding regions with different affinities. PMID:23545135

  7. 28 CFR 5.306 - Exemption under section 3(g) of the Act.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Exemption under section 3(g) of the Act. 5.306 Section 5.306 Judicial Administration DEPARTMENT OF JUSTICE ADMINISTRATION AND ENFORCEMENT OF... officials other than in the course of judicial proceedings, criminal or civil law enforcement...

  8. Crystal Structure of the APOBEC3G Catalytic Domain Reveals Potential Oligomerization Interfaces

    SciTech Connect

    Shandilya, Shivender M.D.; Nalam, Madhavi N.L.; Nalivaika, Ellen A.; Gross, Phillip J.; Valesano, Johnathan C.; Shindo, Keisuke; Li, Ming; Munson, Mary; Royer, William E.; Harjes, Elena; Kono, Takahide; Matsuo, Hiroshi; Harris, Reuben S.; Somasundaran, Mohan; Schiffer, Celia A.

    2010-02-11

    APOBEC3G is a DNA cytidine deaminase that has antiviral activity against HIV-1 and other pathogenic viruses. In this study the crystal structure of the catalytically active C-terminal domain was determined to 2.25 {angstrom}. This structure corroborates features previously observed in nuclear magnetic resonance (NMR) studies, a bulge in the second {beta} strand and a lengthening of the second {alpha} helix. Oligomerization is postulated to be critical for the function of APOBEC3G. In this structure, four extensive intermolecular interfaces are observed, suggesting potential models for APOBEC3G oligomerization. The structural and functional significance of these interfaces was probed by solution NMR and disruptive variants were designed and tested for DNA deaminase and anti-HIV activities. The variant designed to disrupt the most extensive interface lost both activities. NMR solution data provides evidence that another interface, which coordinates a novel zinc site, also exists. Thus, the observed crystallographic interfaces of APOBEC3G may be important for both oligomerization and function.

  9. 78 FR 42107 - Certain Wireless Devices With 3G Capabilities and Components Thereof; Notice of Request for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-15

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Wireless Devices With 3G Capabilities and Components Thereof; Notice of Request for... certain wireless devices with 3G capabilities and components thereof imported by respondents...

  10. Fabrication of large dual-polarized multichroic TES bolometer arrays for CMB measurements with the SPT-3G camera

    NASA Astrophysics Data System (ADS)

    Posada, C. M.; Ade, P. A. R.; Ahmed, Z.; Arnold, K.; Austermann, J. E.; Bender, A. N.; Bleem, L. E.; Benson, B. A.; Byrum, K.; Carlstrom, J. E.; Chang, C. L.; Cho, H. M.; Ciocys, S. T.; Cliche, J. F.; Crawford, T. M.; Cukierman, A.; Czaplewski, D.; Ding, J.; Divan, R.; de Haan, T.; Dobbs, M. A.; Dutcher, D.; Everett, W.; Gilbert, A.; Halverson, N. W.; Harrington, N. L.; Hattori, K.; Henning, J. W.; Hilton, G. C.; Holzapfel, W. L.; Hubmayr, J.; Irwin, K. D.; Jeong, O.; Keisler, R.; Kubik, D.; Kuo, C. L.; Lee, A. T.; Leitch, E. M.; Lendinez, S.; Meyer, S. S.; Miller, C. S.; Montgomery, J.; Myers, M.; Nadolski, A.; Natoli, T.; Nguyen, H.; Novosad, V.; Padin, S.; Pan, Z.; Pearson, J.; Ruhl, J. E.; Saliwanchik, B. R.; Smecher, G.; Sayre, J. T.; Shirokoff, E.; Stan, L.; Stark, A. A.; Sobrin, J.; Story, K.; Suzuki, A.; Thompson, K. L.; Tucker, C.; Vanderlinde, K.; Vieira, J. D.; Wang, G.; Whitehorn, N.; Yefremenko, V.; Yoon, K. W.; Ziegler, K. E.

    2015-09-01

    This work presents the procedures used at Argonne National Laboratory to fabricate large arrays of multichroic transition-edge sensor (TES) bolometers for cosmic microwave background (CMB) measurements. These detectors will be assembled into the focal plane for the SPT-3G camera, the third generation CMB camera to be installed in the South Pole Telescope. The complete SPT-3G camera will have approximately 2690 pixels, for a total of 16 140 TES bolometric detectors. Each pixel is comprised of a broad-band sinuous antenna coupled to a Nb microstrip line. In-line filters are used to define the different bands before the millimeter-wavelength signal is fed to the respective Ti/Au TES bolometers. There are six TES bolometer detectors per pixel, which allow for measurements of three band-passes (95, 150 and 220 GHz) and two polarizations. The steps involved in the monolithic fabrication of these detector arrays are presented here in detail. Patterns are defined using a combination of stepper and contact lithography. The misalignment between layers is kept below 200 nm. The overall fabrication involves a total of 16 processes, including reactive and magnetron sputtering, reactive ion etching, inductively coupled plasma etching and chemical etching.

  11. Sunphotometric Measurement of Columnar H2O and Aerosol Optical Depth During the 3rd Water Vapor IOP in Fall 2000 at the SGP ARM Site

    NASA Technical Reports Server (NTRS)

    Schmid, B; Eilers, J. A.; McIntosh, D. M.; Longo, K.; Livingston, J. M.; Redemann, J.; Russell, P. B.; Braun, J.; Rocken, C.; Hipskind, R. Stephen (Technical Monitor)

    2001-01-01

    We conducted ground-based measurements with the Ames Airborne Tracking 6-channel Sunphotometer (AATS-6) during the 3rd Water Vapor IOP (WVIOP3), September 18 - October 8, 2000 at the SGP ARM site. For this deployment our primary result was columnar water vapor (CWV) obtained from continuous solar transmittance measurements in the 0.94-micron band. In addition, we simultaneously measured aerosol optical depth (AOD) at 380, 450, 525, 864 and 1020 nm. During the IOP, preliminary results of CWV and AOD were displayed in real-time. The result files were made available to other investigators by noon of the next day. During WVIOP3 those data were shown on the daily intercomparison plots on the IOP web-site. Our preliminary results for CWV fell within the spread of values obtained from other techniques. After conclusion of WVIOP3, AATS-6 was shipped directly to Mauna Loa, Hawaii for post-mission calibration. The updated calibration, a cloud screening technique for AOD, along with other mostly cosmetic changes were applied to the WVIOP3 data set and released as version 0.1. The resulting changes in CWV are small, the changes in AOD and Angstrom parameter are more noticeable. Data version 0.1 was successfully submitted to the ARM External Data Center. In the poster we will show data examples for both CWV and AOD. We will also compare our CWV results with those obtained from a GPS (Global Positioning System) slant path method.

  12. Stable Isotope and Trace Element Studies on Gladiators and Contemporary Romans from Ephesus (Turkey, 2nd and 3rd Ct. AD) - Implications for Differences in Diet

    PubMed Central

    Lösch, Sandra; Moghaddam, Negahnaz; Grossschmidt, Karl; Risser, Daniele U.; Kanz, Fabian

    2014-01-01

    The gladiator cemetery discovered in Ephesus (Turkey) in 1993 dates to the 2nd and 3rd century AD. The aim of this study is to reconstruct diverse diet, social stratification, and migration of the inhabitants of Roman Ephesus and the distinct group of gladiators. Stable carbon, nitrogen, and sulphur isotope analysis were applied, and inorganic bone elements (strontium, calcium) were determined. In total, 53 individuals, including 22 gladiators, were analysed. All individuals consumed C3 plants like wheat and barley as staple food. A few individuals show indication of consumption of C4 plants. The δ13C values of one female from the gladiator cemetery and one gladiator differ from all other individuals. Their δ34S values indicate that they probably migrated from another geographical region or consumed different foods. The δ15N values are relatively low in comparison to other sites from Roman times. A probable cause for the depletion of 15N in Ephesus could be the frequent consumption of legumes. The Sr/Ca-ratios of the gladiators were significantly higher than the values of the contemporary Roman inhabitants. Since the Sr/Ca-ratio reflects the main Ca-supplier in the diet, the elevated values of the gladiators might suggest a frequent use of a plant ash beverage, as mentioned in ancient texts. PMID:25333366

  13. Evidence of human-induced morphodynamic changes along the Campania coastal areas (southern Italy) since the 3rd-4th cent. AD

    NASA Astrophysics Data System (ADS)

    Russo Ermolli, Elda; Romano, Paola; Liuzza, Viviana; Amato, Vincenzo; Ruello, Maria Rosaria; Di Donato, Valentino

    2014-05-01

    Campania has always offered suitable climatic and physiographic conditions for human settlements since prehistoric times. In particular, many Graeco-Roman towns developed along its coasts starting from the 7th-6th cent. BC. In the last decade, geoarchaelogical surveys have been carried out in the archaeological excavations of Neapolis, Paestum and Elea-Velia allowing the main steps of the landscape evolution around these towns to be defined in detail. The greek town of Neapolis rose in the late 6th cent. BC [1] on a terrace overlooking a low-relief rocky coast surrounded by volcanic hills. Port activities developed in a protected bay facing the town from the 4th-2nd cent. BC up to the 4th cent. AD, as testified by the discovery of structures and shipwrecks [2, 3, 4]. Starting from the 3rd cent. AD a spit bar formed at the bay entrance causing the progressive establishment of a lagoon which was gradually filled up by alluvial inputs and completely closed in the 5th cent. AD. During the same period, episodes of increased alluvial inputs were also recorded further west along the coast, where a narrow sandy beach formed at the cliff toe. The greek town of Poseidonia, renamed Paestum by the Romans, was founded in the 540 BC on a travertine terrace facing the sandy littoral of a prograding coastal plain [5]. In front of the main town door, a coastal lagoon developed thanks to the growth of a dune ridge and was probably used for harbor activities [5]. After this period the shoreline shifted seawards, another dune ridge formed and the back-ridge depression was filled with fluvial-marshy deposits, slowly drying up. Phases of travertine deposition, which characterized the SE sector of the plain all along the Holocene, were recorded in the northern and southern quarters of the town in historical times and were connected to the abandonment of the town in the early Medieval times. The greek colony of Elea-Velia was located on top of a siliciclastic promontory where the ruins of

  14. In vitro effects of three woody plant and sainfoin extracts on 3rd-stage larvae and adult worms of three gastrointestinal nematodes.

    PubMed

    Paolini, V; Fouraste, I; Hoste, H

    2004-07-01

    Most studies on the effects of tanniferous plants on nematodes have examined forages but have neglected the woody plants. Therefore, in vitro effects of extracts from 3 woody plants (Rubus fructicosus, Quercus robur, Corylus avellana) have been tested on trichostrongyles and compared to sainfoin, a legume forage. Because some in vivo results indicated that the effects of tannins differed depending on the parasitic species and/or stages, the effects were measured on 3rd-stage larvae (L3) and adult worms of Teladorsagia circumcincta, Haemonchlus contortus and Trichostrongylus colubriformis. The effects of plant extracts varied according to the plant sources, the parasite species and stages. For the woody plants, significant inhibitory effects were obtained on both stages of abomasal species. Results for T. colubriformis were more variable. Effects of sainfoin extracts were significant on T. colubriformis and H. contortus L3, and on abomasal adult worms. In order to assess the implications of tannins, polyethylene glycol (PEG), an inhibitor of tannins, was added to hazel tree, oak and sainfoin extracts. Without PEG, significant inhibitory effects on L3 and adult worms were confirmed. After addition of PEG, the larval migration and motility of adult worms were restored in most cases. These results confirm variations in effects depending on factors related to plants or parasites and suggest that tannins are partly responsible for the effects. PMID:15267113

  15. 78 FR 8191 - Certain Wireless Devices With 3G and/or 4G Capabilities and Components Thereof; Institution of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-05

    ... COMMISSION Certain Wireless Devices With 3G and/or 4G Capabilities and Components Thereof; Institution of... certain wireless devices with 3G and/or 4G capabilities and components thereof by reason of infringement... wireless devices with 3G and/or 4G capabilities and components thereof by reason of infringement of one...

  16. 76 FR 54252 - In the Matter of Certain Wireless Devices With 3G Capabilities and Components Thereof; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-31

    ... COMMISSION In the Matter of Certain Wireless Devices With 3G Capabilities and Components Thereof; Notice of... importation, and the sale within the United States after importation of certain wireless devices with 3G... after ] importation of certain wireless devices with 3G capabilities and components thereof...

  17. HIV-1 Adapts To Replicate in Cells Expressing Common Marmoset APOBEC3G and BST2

    PubMed Central

    Fernández-Oliva, Alberto; Finzi, Andrés; Haim, Hillel; Menéndez-Arias, Luis; Sodroski, Joseph

    2015-01-01

    ABSTRACT Previous studies have shown that a major block to HIV-1 replication in common marmosets operates at the level of viral entry and that this block can be overcome by adaptation of the virus in tissue-cultured cells. However, our current studies indicate that HIV-1 encounters additional postentry blocks in common marmoset peripheral blood mononuclear cells. Here, we show that the common marmoset APOBEC3G (A3G) and BST2 proteins block HIV-1 in cell cultures. Using a directed-evolution method that takes advantage of the natural ability of HIV-1 to mutate during replication, we have been able to overcome these blocks in tissue-cultured cells. In the adapted viruses, specific changes were observed in gag, vif, env, and nef. The contribution of these changes to virus replication in the presence of the A3G and BST2 restriction factors was studied. We found that certain amino acid changes in Vif and Env that arise during adaptation to marmoset A3G and BST2 allow the virus to replicate in the presence of these restriction factors. The changes in Vif reduce expression levels and encapsidation of marmoset APOBEC3G, while the changes in Env increase viral fitness and discretely favor cell-to-cell transmission of the virus, allowing viral escape from these restriction factors. IMPORTANCE HIV-1 can infect only humans and chimpanzees. The main reason for this narrow tropism is the presence in many species of dominant-acting factors, known as restriction factors, that block viral replication in a species-specific way. We have been exploring the blocks to HIV-1 in common marmosets, with the ultimate goal of developing a new animal model of HIV-1 infection in these monkeys. In this study, we observed that common marmoset APOBEC3G and BST2, two known restriction factors, are able to block HIV-1 in cell cultures. We have adapted HIV-1 to replicate in the presence of these restriction factors and have characterized the mechanisms of escape. These studies can help in the

  18. A Generation Immersed in Media

    ERIC Educational Resources Information Center

    Azzam, Amy M.

    2006-01-01

    This article briefly reports the findings of "Generation M: Media in the Lives of 8-18 Year-Olds," a study conducted by the Kaiser Family Foundation and Stanford University researchers. The report studied media use a nationally representative sample of more than 2,000 3rd through 12th graders in the United States. The study found that although the…

  19. APOBEC3G Variants and Protection against HIV-1 Infection in Burkina Faso.

    PubMed

    Compaore, Tegwinde Rebeca; Soubeiga, Serge Theophile; Ouattara, Abdoul Karim; Obiri-Yeboah, Dorcas; Tchelougou, Damehan; Maiga, Mamoudou; Assih, Maleki; Bisseye, Cyrille; Bakouan, Didier; Compaore, Issaka Pierre; Dembele, Augustine; Martinson, Jeremy; Simpore, Jacques

    2016-01-01

    Studies on host factors, particularly the APOBEC3G gene, have previously found an association with AIDS progression in some populations and against some HIV-1 strains but not others. Our study had two main objectives: firstly, to screen a population from Burkina Faso for three variants of APOBEC3G previously described, and secondly to analyze the effect of these three variants and their haplotypes on HIV-1 infection with Circulating Recombinant Forms (CRFs) present in Burkina Faso. This case control study involved 708 seropositive and seronegative individuals. Genotyping was done by the TaqMan allelic discrimination method. Minor allele frequencies of rs6001417 (p<0.05), rs8177832 (P<0.05), and rs35228531 (P<0.001) were higher in seronegative subjects. The rs6001417 and rs8177832 SNPs were associated with HIV-1 infection in an additive model (P<0.01). Furthermore the SNP rs35228531 was also associated with HIV-1 infection in a dominant model (P<0.001). Odds ratio analysis of genotypes and alleles of the different APOBEC3G variants showed that there is a strong association between the minor genetic variants, genotype of the three SNPs, and HIV-1 status. Haplotype analysis demonstrated that rs6001417, rs8177832, and rs35228531 are in linkage disequilibrium. The haplotype GGT from the rs6001417, rs8177832 and rs35228531 respectively has a protective effect OR = 0.54 [0.43-0.68] with P<0.001. There was also associations between the haplotypes GGC OR = 1.6 [1.1;-2.3] P<0.05, and CGC OR = 5.21 [2.4-11.3] P<0.001, which increase the risk of infection by HIV-1 from almost two (2) to five (5) fold. This study demonstrates an association of rs6001417, rs8177832, and rs35228531 of APOBEC3G with HIV-1 infection in a population from Burkina Faso. PMID:26741797

  20. Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G

    PubMed Central

    Crosby, David C.; Kim, Dong Young; Kwon, Eunju; Yen, Linda; Cartozo, Nathalie Caretta; Li, Ming; Jäger, Stefanie; Mason-Herr, Jeremy; Hayashi, Fumiaki; Yokoyama, Shigeyuki; Krogan, Nevan J.; Harris, Reuben S.; Peterlin, Boris Matija; Gross, John D.

    2012-01-01

    Cellular restriction factors help to defend humans against human immunodeficiency virus (HIV). HIV accessory proteins hijack at least three different Cullin-RING ubiquitin ligases, which must be activated by the small ubiquitin-like protein NEDD8, in order to counteract host cellular restriction factors. We found that conjugation of NEDD8 to Cullin-5 by the NEDD8-conjugating enzyme UBE2F is required for HIV Vif-mediated degradation of the host restriction factor APOBEC3G (A3G). Pharmacological inhibition of the NEDD8 E1 by MLN4924 or knockdown of either UBE2F or its RING-protein binding partner RBX2 bypasses the effect of Vif, restoring the restriction of HIV by A3G. NMR mapping and mutational analyses define specificity determinants of the UBE2F NEDD8 cascade. These studies demonstrate that disrupting host NEDD8 cascades presents a novel antiretroviral therapeutic approach enhancing the ability of the immune system to combat HIV. PMID:23300442

  1. Stellar Occultations by Large TNOs on 2012: The February 3rd by (208996) 2003 AZ84, and the February 17th by (50000) Quaoar

    NASA Astrophysics Data System (ADS)

    Braga Ribas, Felipe; Sicardy, B.; Ortiz, J. L.; Duffard, R.; Camargo, J. I. B.; Lecacheux, J.; Colas, F.; Vachier, F.; Tanga, P.; Sposetti, S.; Brosch, N.; Kaspi, S.; Manulis, I.; Baug, T.; Chandrasekhar, T.; Ganesh, S.; Jain, J.; Mohan, V.; Sharma, A.; Garcia-Lozano, R.; Klotz, A.; Frappa, E.; Jehin, E.; Assafin, M.; Vieira Martins, R.; Behrend, R.; Roques, F.; Widemann, T.; Morales, N.; Thirouin, A.; Mahasena, P.; Benkhaldoun, Z.; Daassou, A.; Rinner, C.; Ofek, E. O.

    2012-10-01

    On February 2012, two stellar occultation's by large Trans-neptunian Objects (TNO's) were observed by our group. On the 3rd, an event by (208996) 2003 AZ84 was recorded from Mont Abu Observatory and IUCAA Girawali Observatory in India and from Weizmann Observatory in Israel. On the 17th, a stellar occultation by (50000) Quaoar was observed from south France and Switzerland. Both occultations are the second observed by our group for each object, and will be used to improve the results obtained on the previous events. The occultation by 2003 AZ84 is the first multi-chord event recorded for this object. From the single chord event on January 8th 2011, Braga-Ribas et al. 2011 obtained a lower limit of 573 +/- 21 km. From the 2012 occultation the longest chord has a size of 662 +/- 50 km. The other chords will permit to determine the size and shape of the TNO, and derive other physical parameters, such as the geometric albedo. The Quaoar occultation was observed from south of France (Observatoire de la Côte d'Azur, TAROT telescope and Valensole) and from Gnosca, Switzerland. Unfortunately, all three sites in France are almost at the same Quaoar's latitude, so in practice, we have two chords that can be used to fit Quaoar's limb. The resulting fit will be compared with the results obtained by Braga-Ribas et al. 2011. Braga-Ribas F., Sicardy B., et al. 2011, EPSC-DPS2011, 1060.Ribas F., Sicardy B., et al. 2011, EPSC-DPS2011, 1060.

  2. Medical school curriculum characteristics associated with intentions and frequency of tobacco dependence treatment among 3rd year U.S. medical students

    PubMed Central

    Hayes, Rashelle B.; Geller, Alan C.; Crawford, Sybil L.; Jolicoeur, Denise; Churchill, Linda C.; Okuyemi, Kola; David, Sean P.; Adams, Michael; Waugh, Jonathan; Allen, Sharon S.; Leone, Frank T.; Fauver, Randy; Leung, Katherine; Liu, Qin; Ockene, Judith K.

    2015-01-01

    Objective Physicians play a critical role in addressing tobacco dependence, yet report limited training. Tobacco dependence treatment curricula for medical students could improve performance in this area. This study identified student and medical school tobacco treatment curricula characteristics associated with intentions and use of the 5As for tobacco treatment among 3rd year U.S. medical students. Methods Third year medical students (N=1065, 49.3% male) from 10 U.S. medical schools completed a survey in 2009-2010 assessing student characteristics, including demographics, tobacco treatment knowledge, and self-efficacy. Tobacco curricula characteristics assessed included amount and type of classroom instruction, frequency of tobacco treatment observation, instruction, and perception of preceptors as role models. Results Greater tobacco treatment knowledge, self-efficacy, and curriculum-specific variables were associated with 5A intentions, while younger age, tobacco treatment self-efficacy, intentions, and each curriculum-specific variable was associated with greater 5A behaviors. When controlling for important student variables, greater frequency of receiving 5A instruction (OR = 1.07; 95%CI 1.01-1.12) and perception of preceptors as excellent role models in tobacco treatment (OR = 1.35; 95%CI 1.04-1.75) were significant curriculum predictors of 5A intentions. Greater 5A instruction (B = .06 (.03); p< .05) and observation of tobacco treatment (B= .35 (.02); p< .001) were significant curriculum predictors of greater 5A behaviors. Conclusions Greater exposure to tobacco treatment teaching during medical school is associated with both greater intentions to use and practice tobacco 5As. Clerkship preceptors, or those physicians who provide training to medical students, may be particularly influential when they personally model and instruct students in tobacco dependence treatment. PMID:25572623

  3. US Marine 3rd Tank Battalion lubrication evaluation under hot ambient temperatures at Twenty-Nine Palms, California. Interim report, April-September 1988

    SciTech Connect

    Butler, W.E.; Owens, E.C.; Frame, E.A.; Bowen, T.C.

    1988-09-01

    Military Specification MIL-L-2104D, Lubricating Oil, Internal Combustion Engines, Tactical Service, was released 1 April 1983. This specification included a multiviscosity OE/HDO-15/40 oil and eliminated a previously authorized OE/HDO-50 oil. The manufacturer of the AVDS-1790 series engines used in M60 battle tanks and M88 tank retrievers raised raised concerns about warranty coverage. The U.S. Marine Corps indicated that the use of the authorized 15W-40 grade oil did not offer sufficient lubrication for the engines and also resulted in M60 final drive leaks. As a result of these concerns, the U.S. Army Belvoir Research, Development and Engineering Center (Belvoir RDE Center) authorized an oil comparison test that, by agreement with the U.S. Marine Corps, would be conducted at the U.S. Marine Corps Air-Ground Combat Center (USMCAGCC) at Twenty-Nine Palms, CA using the U.S. Marine 3rd Tank Battalion (3DTKBn). The test vehicles of A Company, 3DTKBn were charged with regular issue 50-grade oil in the engine, 10-grade oil in the transmission, and 50-grade oil in the M60 final drives. B Company's test vehicles were charged with 15W-40 grade oil in the engines, transmissions, and M60 final drives. C Company's test vehicles were charged with 40-grade oil in the engines, 10-grade oil in the transmissions, and 50-grade oil in the final drives. Results from this 4-month test indicated no discernible differences in engine or transmission operating temperatures, engine oil pressures, or M60 final drive leaks.

  4. Non-destructive measurement of demineralization and remineralization in the occlusal pits and fissures of extracted 3rd molars with PS-OCT

    NASA Astrophysics Data System (ADS)

    Lee, Chulsung; Hsu, Dennis J.; Le, Michael H.; Darling, Cynthia L.; Fried, Daniel

    2009-02-01

    Previous studies have demonstrated that Polarization Sensitive Optical Coherence Tomography (PS-OCT) can be used to image the remineralization of early artificial caries lesion on smooth enamel surfaces of human and bovine teeth. However, most new dental decay is found in the pits and fissures of the occlusal surfaces of posterior dentition and it is in these high risk areas where the performance of new caries imaging devices need to be investigated. The purpose of this study was to demonstrate that PS-OCT can be used to measure the subsequent remineralization of artificial lesions produced in the pits and fissures of extracted 3rd molars. A PS-OCT system operating at 1310-nm was used to acquire polarization resolved images of occlusal surfaces exposed to a demineralizing solution at pH-4.5 followed by a fluoride containing remineralizing solution at pH-7.0 containing 2-ppm fluoride. The integrated reflectivity was calculated to a depth of 200-µm in the entire lesion area using an automated image processing algorithm. Although a well-defined surface zone was clearly resolved in only a few of the samples that underwent remineralization, the PS-OCT measurements indicated a significant (p<0.05) reduction in the integrated reflectivity between the severity of the lesions that were exposed to the remineralization solution and those that were not. The lesion depth and mineral loss were also measured with polarized light microscopy and transverse microradiography after sectioning the teeth. These results show that PS-OCT can be used to non-destructively monitor the remineralization potential of anti-caries agents in the important pits and fissures of the occlusal surface.

  5. Ubiquitin-fusion as a strategy to modulate protein half-life: A3G antiviral activity revisited

    SciTech Connect

    Cadima-Couto, Iris; Freitas-Vieira, Acilino; Nowarski, Roni; Britan-Rosich, Elena; Kotler, Moshe; Goncalves, Joao

    2009-10-25

    The human APOBEC3G (A3G) is a potent inhibitor of HIV-1 replication and its activity is suppressed by HIV-1 virion infectivity factor (Vif). Vif neutralizes A3G mainly by inducing its degradation in the proteasome and blocking its incorporation into HIV-1 virions. Assessing the time needed for A3G incorporation into virions is, therefore, important to determine how quickly Vif must act to induce its degradation. We show that modelling the intracellular half-life of A3G can induce its Vif-independent targeting to the ubiquitin-proteasome system. By using various amino acids (X) in a cleavable ubiquitin-X-A3G fusion, we demonstrate that the half-life (t1/2) of X-A3G can be manipulated. We show that A3G molecules with a half-life of 13 min are incorporated into virions, whereas those with a half-life shorter than 5 min were not. The amount of X-A3G incorporated into virions increases from 13 min (Phe-A3G) to 85 min (Asn-A3G) and remains constant after this time period. Interestingly, despite the presence of similar levels of Arg-A3G (t1/2 = 28 min) and Asp-A3G (t1/2 = 65 min) into HIV-1 DELTAvif virions, inhibition of viral infectivity was only evident in the presence of A3G proteins with a longer half-life (t1/2 >= 65 min).

  6. Metabolic engineering of E.coli for the production of a precursor to artemisinin, an anti-malarial drug [Chapter 25 in Manual of Industrial Microbiology and Biotechnology, 3rd edition

    SciTech Connect

    Petzold, Christopher; Keasling, Jay

    2011-07-18

    This document is Chapter 25 in the Manual of Industrial Microbiology and Biotechnology, 3rd edition. Topics covered include: Incorporation of Amorpha-4,11-Diene Biosynthetic Pathway into E. coli; Amorpha-4,11-Diene Pathway Optimization; "-Omics" Analyses for Increased Amorpha-4,11-Diene Production; Biosynthetic Oxidation of Amorpha-4,11-Diene.

  7. Interference from the Deep Space Network's 70-m High Power Transmitter in Goldstone, CA to 3G Mobile Users Operating in the Surrounding Area

    NASA Technical Reports Server (NTRS)

    Ho, Christian

    2004-01-01

    The International Telecommunications Union (ITU) has allocated 2110-2200 MHz for the third generation (3G) mobile services. Part of the spectrum (2110-2120 MHz) is allocated for space research service and has been used by the DSN for years for sending command uplinks to deep space missions. Due to the extremely high power transmitted, potential interference to 3G users in areas surrounding DSN Goldstone exists. To address this issue, a preliminary analytical study has been performed and computer models have been developed. The goal is to provide theoretical foundation and tools to estimate the strength of interference as a function of distance from the transmitter for various interference mechanisms, (or propagation modes), and then determine the size of the area in which 3G users are susceptible to interference from the 400-kW transmitter in Goldstone. The focus is non-line-of-sight interference, taking into account of terrain shielding, anomalous propagation mechanisms, and technical and operational characteristics of the DSN and the 3G services.

  8. Generations.

    PubMed

    Chambers, David W

    2005-01-01

    Groups naturally promote their strengths and prefer values and rules that give them an identity and an advantage. This shows up as generational tensions across cohorts who share common experiences, including common elders. Dramatic cultural events in America since 1925 can help create an understanding of the differing value structures of the Silents, the Boomers, Gen Xers, and the Millennials. Differences in how these generations see motivation and values, fundamental reality, relations with others, and work are presented, as are some applications of these differences to the dental profession. PMID:16623137

  9. APOBEC3G Variants and Protection against HIV-1 Infection in Burkina Faso

    PubMed Central

    Compaore, Tegwinde Rebeca; Soubeiga, Serge Theophile; Ouattara, Abdoul Karim; Obiri-Yeboah, Dorcas; Tchelougou, Damehan; Maiga, Mamoudou; Assih, Maleki; Bisseye, Cyrille; Bakouan, Didier; Compaore, Issaka Pierre; Dembele, Augustine; Martinson, Jeremy; Simpore, Jacques

    2016-01-01

    Studies on host factors, particularly the APOBEC3G gene, have previously found an association with AIDS progression in some populations and against some HIV-1 strains but not others. Our study had two main objectives: firstly, to screen a population from Burkina Faso for three variants of APOBEC3G previously described, and secondly to analyze the effect of these three variants and their haplotypes on HIV-1 infection with Circulating Recombinant Forms (CRFs) present in Burkina Faso. This case control study involved 708 seropositive and seronegative individuals. Genotyping was done by the TaqMan allelic discrimination method. Minor allele frequencies of rs6001417 (p<0.05), rs8177832 (P<0.05), and rs35228531 (P<0.001) were higher in seronegative subjects. The rs6001417 and rs8177832 SNPs were associated with HIV-1 infection in an additive model (P<0.01). Furthermore the SNP rs35228531 was also associated with HIV-1 infection in a dominant model (P<0.001). Odds ratio analysis of genotypes and alleles of the different APOBEC3G variants showed that there is a strong association between the minor genetic variants, genotype of the three SNPs, and HIV-1 status. Haplotype analysis demonstrated that rs6001417, rs8177832, and rs35228531 are in linkage disequilibrium. The haplotype GGT from the rs6001417, rs8177832 and rs35228531 respectively has a protective effect OR = 0.54 [0.43–0.68] with P<0.001. There was also associations between the haplotypes GGC OR = 1.6 [1.1;-2.3] P<0.05, and CGC OR = 5.21 [2.4–11.3] P<0.001, which increase the risk of infection by HIV-1 from almost two (2) to five (5) fold. This study demonstrates an association of rs6001417, rs8177832, and rs35228531 of APOBEC3G with HIV-1 infection in a population from Burkina Faso. PMID:26741797

  10. Develop 3G Application with The J2ME SATSA API

    NASA Astrophysics Data System (ADS)

    JunWu, Xu; JunLing, Liang

    This paper describes research in the use of the Security and Trust Services API for J2ME (SATSA) to develop mobile applications. for 3G networks. SATSA defines a set of APIs that allows J2ME applications to communicate with and access functionality, secure storage and cryptographic operations provided by security elements such as smart cards and Wireless Identification Modules (WIM). A Java Card application could also work as an authentication module in a J2ME-based e-bank application. The e-bank application would allow its users to access their bank accounts using their cell phones.

  11. ICOM2012: 3rd International Conference on the Physics of Optical Materials and Devices (Belgrade, Serbia, 2-6 September 2012)

    NASA Astrophysics Data System (ADS)

    Dramićanin, Miroslav D.; Antić, Željka; Viana, Bruno

    2013-11-01

    The 3rd International Conference on the Physics of Optical Materials and Devices (ICOM2012) was held in Belgrade (Serbia) from 2 to 6 September 2012 (figure 1). The conference was organized by the Vinča Institute of Nuclear Sciences, University of Belgrade (Serbia) and the Laboratoire de Chimie de la Matière Condensée de Paris (France), and supported by the Ministry of Education, Science and Technological Development of the Republic of Serbia and Optical Society of America. ICOM2012 was a follow-up to the two previous, successful ICOM conferences held in Herceg Novi in 2006 and 2009. The conference aimed at providing a forum for scientists in optical materials to debate on: • Luminescent materials and nanomaterials • Hybrid optical materials (organic/inorganic) • Characterization techniques of optical materials • Luminescence mechanisms and energy transfers • Theory and modeling of optical processes • Ultrafast-laser processing of materials • Optical sensors • Medical imaging • Advanced optical materials in photovoltaics and biophotonics • Photothermal and photoacoustic spectroscopy and phenomena The conference stressed the value of a fundamental scientific understanding of optical materials. A particular accent was put on wide band-gap materials in crystalline, glass and nanocrystalline forms. The applications mainly involved lasers, scintillators and phosphors. Rare earth and transition metal ions introduced as dopants in various hosts were considered, and their impact on the optical properties were detailed in several presentations. This volume contains selected contributions of speakers and participants of the ICOM2012 conference. The conference provided a unique opportunity for about 200 scientists from 32 countries to discuss recent progress in the field of optical materials. During the three and half days, 21 invited talks and 52 contributed lectures were given, with a special event in memory of our dear colleague Professor Dr Tsoltan

  12. Atomic force microscopy studies provide direct evidence for dimerization of the HIV restriction factor APOBEC3G.

    PubMed

    Shlyakhtenko, Luda S; Lushnikov, Alexander Y; Li, Ming; Lackey, Lela; Harris, Reuben S; Lyubchenko, Yuri L

    2011-02-01

    APOBEC3G (A3G) is an antiviral protein that binds RNA and single-stranded DNA (ssDNA). The oligomerization state of A3G is likely to be influenced by these nucleic acid interactions. We applied the power of nanoimaging atomic force microscopy technology to characterize the role of ssDNA in A3G oligomerization. We used recombinant human A3G prepared from HEK-293 cells and specially designed DNA substrates that enable free A3G to be distinguished unambiguously from DNA-bound protein complexes. This DNA substrate can be likened to a molecular ruler because it consists of a 235-bp double-stranded DNA visual tag spliced to a 69-nucleotide ssDNA substrate. This hybrid substrate enabled us to use volume measurements to determine A3G stoichiometry in both free and ssDNA-bound states. We observed that free A3G is primarily monomeric, whereas ssDNA-complexed A3G is mostly dimeric. A3G stoichiometry increased slightly with the addition of Mg(2+), but dimers still predominated when Mg(2+) was depleted. A His-248/His-250 Zn(2+)-mediated intermolecular bridge was observed in a catalytic domain crystal structure (Protein Data Bank code 3IR2); however, atomic force microscopy analyses showed that the stoichiometry of the A3G-ssDNA complexes changed insignificantly when these residues were mutated to Ala. We conclude that A3G exchanges between oligomeric forms in solution with monomers predominating and that this equilibrium shifts toward dimerization upon binding ssDNA. PMID:21123176

  13. Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid

    PubMed Central

    Derse, David; Hill, Shawn A.; Princler, Gerald; Lloyd, Patricia; Heidecker, Gisela

    2007-01-01

    Human T cell leukemia virus type 1 (HTLV-1) has evolved a remarkable strategy to thwart the antiviral effects of the cellular cytidine deaminase APOBEC3G (hA3G). HTLV-1 infects T lymphocytes in vivo, where, like HIV-1, it is likely to encounter hA3G. HIV-1 counteracts the innate antiviral activity of hA3G by producing an accessory protein, Vif, which hastens the degradation of hA3G. In contrast, HTLV-1 does not encode a Vif homologue; instead, HTLV-1 has evolved a cis-acting mechanism to prevent hA3G restriction. We demonstrate here that a peptide motif in the C terminus of the HTLV-1 nucleocapsid (NC) domain inhibits hA3G packaging into nascent virions. Mutation of amino acids within this region resulted in increased levels of hA3G incorporation into virions and increased susceptibility to hA3G restriction. Elements within the C-terminal extension of the NC domain are highly conserved among the primate T cell leukemia viruses, but this extension is absent in all other retroviral NC proteins. PMID:17299050

  14. Research of the Heart Information Monitoring Robert Based on the 3G Wireless Communication Platform

    NASA Astrophysics Data System (ADS)

    Zhang, Fuli; Yang, Huazhe; Li, Gensong; Hong, Yang; Hu, Qingzhe

    Electrocardiogram (ECG) of a person can be recorded and the diagnostic results can be displayed through touching the heart information monitoring Robert. In addition, the heart rate, phonocardiogram (PCG) and the dynamic three-dimensional echocardiography can also be displayed synchronously. Then the difficult ECG can be transmitted to the service center through 3G wireless communication center, followed by diagnosing the ECG by doctors and transmitting the feedback diagnostic results. I-lead ECG of the person can be recorded by the amplification circuit with high gain and low noise. Then, the heart rate and output phonocardiogram are displayed and the model of heart beat are started to trace through the recognition of R wave. Finally, the difficult ECG is transmitted to the service center via 3G communication chips. The displayed ECG is clear, and the stimulated heart beat is synchronous with that of the person. Furthermore, ECG received by the service center is in accordance with the one recorded by the Robert.

  15. A remote patient monitoring system using a Java-enabled 3G mobile phone.

    PubMed

    Zhang, Pu; Kogure, Yuichi; Matsuoka, Hiroki; Akutagawa, Masatake; Kinouchi, Yohsuke; Zhang, Qinyu

    2007-01-01

    Telemedicine systems have become an important supporting for the medical staffs. As the development of the mobile phones, it is possible to apply the mobile phones to be a part of telemedicine systems. We developed an innovative Remote Patient Monitoring System using a Java-enabled 3G mobile phone. By using this system, doctors can monitor the vital biosignals of patients in ICU/CCU, such as ECG, RESP, SpO2, EtCO2 and so on by using the real-time waveform and data monitoring and list trend data monitoring functions of installed Java jiglet application on the mobile phone. Futhermore, doctors can check the patients' information by using the patient information checking function. The 3G mobile phone used has the ability to implement the application as the same time as being used to mak a voice call. Therefore, the doctor can get more and more information both from the browsing the screen of the mobile phone and the communicating with the medical staffs who are beside the patients and the monitors. The system can be conducted to evaluate the diagnostic accuracy, efficiency, and safety of telediagnosis. PMID:18002804

  16. Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein*

    PubMed Central

    Pery, Erez; Sheehy, Ann; Nebane, N. Miranda; Brazier, Andrew Jay; Misra, Vikas; Rajendran, Kottampatty S.; Buhrlage, Sara J.; Mankowski, Marie K.; Rasmussen, Lynn; White, E. Lucile; Ptak, Roger G.; Gabuzda, Dana

    2015-01-01

    APOBEC3G (A3G) is a cellular cytidine deaminase that restricts HIV-1 replication by inducing G-to-A hypermutation in viral DNA and by deamination-independent mechanisms. HIV-1 Vif binds to A3G, resulting in its degradation via the 26 S proteasome. Therefore, this interaction represents a potential therapeutic target. To identify compounds that inhibit interaction between A3G and HIV-1 Vif in a high throughput format, we developed a homogeneous time-resolved fluorescence resonance energy transfer assay. A 307,520 compound library from the NIH Molecular Libraries Small Molecule Repository was screened. Secondary screens to evaluate dose-response performance and off-target effects, cell-based assays to identify compounds that attenuate Vif-dependent degradation of A3G, and assays testing antiviral activity in peripheral blood mononuclear cells and T cells were employed. One compound, N.41, showed potent antiviral activity in A3G(+) but not in A3G(−) T cells and had an IC50 as low as 8.4 μm and a TC50 of >100 μm when tested against HIV-1Ba-L replication in peripheral blood mononuclear cells. N.41 inhibited the Vif-A3G interaction and increased cellular A3G levels and incorporation of A3G into virions, thereby attenuating virus infectivity in a Vif-dependent manner. N.41 activity was also species- and Vif-dependent. Preliminary structure-activity relationship studies suggest that a hydroxyl moiety located at a phenylamino group is critical for N.41 anti-HIV activity and identified N.41 analogs with better potency (IC50 as low as 4.2 μm). These findings identify a new lead compound that attenuates HIV replication by liberating A3G from Vif regulation and increasing its innate antiviral activity. PMID:25724652

  17. SIMULATION OF GENERAL ANESTHESIA ON THE "SIMMAN 3G" AND ITS EFFICIENCY.

    PubMed

    Potapov, A F; Matveev, A S; Ignatiev, V G; Ivanova, A A; Aprosimov, L A

    2015-01-01

    In recent years in medical educational process new innovative technologies are widely used with computer simulation, providing the reality of medical intervations and procedures. Practice-training teaching with using of simulation allows to improve the efficiency of learning material at the expense of creating imaginary professional activity and leading barring material to practical activity. The arm of the investigation is evaluation of the students training efficiency at the Medical Institute on the topic "General Anesthesia with using a modern simulation "SimMan 3 G". The material of the investigation is the results, carried out on the basis of the Centre of Practical skills and medical virtual educational technologies (Simulation Centre) at the Medical Institute of NEFU by M.K. Ammosov. The Object of the investigation was made up by 55 students of the third (3) course of the Faculty of General Medicine of the Medical Institute of NEFU. The investigation was hold during practical trainings (April-May 2014) of the General Surgery Department on the topic "General Anesthesia". A simulation practical course "General Anesthesia" consisted of 12 academic hours. Practical training was carried out using instruments, equipments and facilities to install anesthesia on the SimMan 3G with shooting the process and further discussions of the results. The methods of the investigations were the appreciation of students background knowledge before and after practical training (by 5 points scale) and the analysis of the results. The results of the investigation showed that before the practical course only 23 students (41.8%) had dot positive marks: "Good"--7 students (12.7%) and "Satisfactory"--16 (29.1%) students. The rest 22 (58.2%) students had bad results. The practical trainings using real instruments, equipments and facilities with imitation of installation of preparations for introductory anesthesia, main analgesics and muscle relaxants showed a patients reaction on the

  18. [Cold agglutinin disease -  no response to glucocorticoids and rituximab, what treatment is best for the 3rd line of therapy? Case report and review of the literature].

    PubMed

    Adam, Z; Pejchalová, A; Chlupová, G; Ríhová, L; Pour, L; Krejčí, M; Cervinek, L; Král, Z; Mayer, J

    2013-09-01

    in about one  half of treated patients and the remission duration median after rituximab administration is 11 months. A combination of rituximab with fludarabin was more effective, though more toxic; this combination, in a clinical study, led to 75% of patients responding to treatment, including 20% experiencing complete remission. The treatment response median reached over 66 months. In a small study (10 patients) an increase in the amount of rituximab administrations from 4 to 8 led to a treatment response in 6 patients in whom administration of 4 doses of rituximab had no response. When treating Waldenström macroglobulinemia, effectiveness of the following drugs and their combinations was proven: rituximab, chlorambucil, cyclophosphamide, fludarabin, bortezomib, lenalidomid, bendamustin and alemtuzumab. The same drugs and treatment procedures are used for the treatment of the cold agglutinin disease as for Waldenström macroglobulinemia. Successful treatment with vortezomibem, combinations of rituximab + bendamustin, rituximab + cyclophosphamide or rituximab + fludarabin + cyclophosphamide, were recorded in the form of a description as regards the cold agglutinin disease treatment. An important benefit is also shown through treatment with the monoclonal antibody antiC5, eculizumab, which is otherwise used for the treatment of paroxysmal nocturnal haemoglobinuria. Eculizumab blocks the C5 element of the component and thus stops haemolysis in a patient with cold agglutinin disease. As cold agglutinin disease is very rare, there are only a few clinical studies and when treating this rare disease we have no other option than to take into account the information contained in the descriptions of the particular cases of cold agglutinin disease and the experience of Waldenström macroglobulinemia disease treatment. The discussion seeks to solve the issue regarding what 3rd line treatment option to use in the described patient. PMID:24073955

  19. Joint conference of iMEC 2015 (2nd International Manufacturing Engineering Conference & APCOMS 2015 (3rd Asia-Pacific Conference on Manufacturing Systems)

    NASA Astrophysics Data System (ADS)

    2016-02-01

    The iMEC 2015 is the second International Manufacturing Engineering Conference organized by the Faculty of Manufacturing, Universiti Malaysia Pahang (UMP), held from 12-14th November 2015 in Kuala Lumpur, Malaysia, with a theme "Materials, Manufacturing and Systems for Tomorrow". For the first time, iMEC is organized together with 3rd Asia- Pacific Conference on Manufacturing System (APCOMS 2015) which owned by Fakulti Teknologi Industri, Institut Teknologi Bandung (ITB), Indonesia. This is an extended collaboration between UMP and ITB to intensify knowledge sharing and experiences between higher learning institutions. This conference (iMEC & APCOMS 2015) is a platform for knowledge exchange and the growth of ideas, particularly in manufacturing engineering. The conference aims to bring researchers, academics, scientists, students, engineers and practitioners from around the world together to present their latest findings, ideas, developments and applications related to manufacturing engineering and other related research areas. With rapid advancements in manufacturing engineering, iMEC is an appropriate medium for the associated community to keep pace with the changes. In 2015, the conference theme is “Materials, Manufacturing and Systems for Tomorrow” which reflects the acceleration of knowledge and technology in global manufacturing. The papers in these proceedings are examples of the work presented at the conference. They represent the tip of the iceberg, as the conference attracted over 200 abstracts from Malaysia, Indonesia, Japan, United Kingdom, Australia, India, Bangladesh, South Africa, Turkey and Morocco and 151 full papers were accepted in these proceedings. The conference was run in four parallel sessions with 160 presenters sharing their latest finding in the areas of manufacturing process, systems, advanced materials and automation. The first keynote presentation was given by Prof. B. S. Murthy (IIT, Madras) on "Nanomaterials with Exceptional

  20. Stages of Geoinformation Evolution Related to the Territories Described in the Bible - from the 3Rd Millennium B.C. to Modern Times

    NASA Astrophysics Data System (ADS)

    Linsenbarth, Adam

    2012-09-01

    The paper presents consecutive stages of the evolution of geoinformation related to the territories of the events described in the Bible. Two geoinformation sources are presented: the Bible and non-Bible sources. In the Bible there is much, often some highly detailed information regarding terrain topography. The oldest non-Bible sources are incorporated in the ancient documents, which were discovered in Egypt and Mesopotamia. Some of them are related to the 3rd millen- nium B.C. The further stages are related to the onomasticons and itineraries written by travellers and pilgrims to the Holy Land. The most famous onomasticons include: onomasticons prepared by bishop Eusebius from Caesarea and those pre- pared by St. Jerome. One of the oldest maps of Palestine's territory is the so-called mosaic map of Madaba dated to 565. In the 15th century several Bible maps were edited. The most rapid evolution occurred in the 16th and 17* centuries, when the world famous cartographers such as Mercator and Ortelius edited several maps of Palestine's territory. Cartographers from several European countries edited more than 6,000 maps presenting the Biblical territories and Biblical events. Modem maps, based on detailed topographical surveys, were edited m the second half of the 19* and 20th centuries. W artykule przedstawiono kolejne etapy rozwoju geoinformacji dotyczącej terenówr biblijnych. Omówiono dwa źródła informacji, a mianowicie geoinformacje biblijne i pozabiblijne. W tekstach biblijnych można znaleźć wiele, często bardzo detalicznych informacji topograficznych. Najstarsze źródła pozabiblijne, to starożytne dokumenty odnalezione na terenach Egiptu i Mezopotamii. Niektóre z nich pochodzą z trzeciego milenium przed Chr. Kolejnym etapem geoinformacji były onomastikony oraz dzienniki podróży pisane przez podróżników i pielgrzymów do Ziemi Świętej. Do najbardziej znanych należy onomastikon sporządzony przez biskupa Euzebiusza z Cezarei oraz

  1. Structure at 1.6 Å resolution of the protein from gene locus At3g22680 from Arabidopsis thaliana

    SciTech Connect

    Allard, Simon T. M.; Bingman, Craig A.; Johnson, Kenneth A.; Wesenberg, Gary E.; Bitto, Eduard; Jeon, Won Bae; Phillips, George N. Jr

    2005-07-01

    The crystal structure of the 18 kDa At3g22680 gene product from A. thaliana was determined at 1.6 Å resolution. At3g22680 shows no structural homology to any other known proteins and represents a new fold in protein conformational space. The gene product of At3g22680 from Arabidopsis thaliana codes for a protein of unknown function. The crystal structure of the At3g22680 gene product was determined by multiple-wavelength anomalous diffraction and refined to an R factor of 16.0% (R{sub free} = 18.4%) at 1.60 Å resolution. The refined structure shows one monomer in the asymmetric unit, with one molecule of the non-denaturing detergent CHAPS (3-[(3-cholamidopropyl)dimethylammonio]-1-propane sulfonate) tightly bound. Protein At3g22680 shows no structural homology to any other known proteins and represents a new fold in protein conformation space.

  2. Rosse, 3rd Earl of [William Parsons, Lord Rosse, Lord Oxmantown] (1800-67) and Rosse, 4th Earl of [Laurence Parsons, Lord Rosse, Lord Oxmantown] (1840-1908)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Irish astronomer and landowner, the 3rd Lord Rosse was educated at Trinity College, Dublin and Oxford as a mathematician. He became interested in astronomy and made at the family castle in Birr a 36 in reflector with the same design as William Herschel's (see HERSCEL FAMILY). Mapped the Moon, and observed nebulae with the intent to resolve them into stars. He developed the technology at Birr Cast...

  3. HBsAg blocks TYPE I IFN induced up-regulation of A3G through inhibition of STAT3.

    PubMed

    Xu, Fengchao; Song, Hongxiao; Li, Na; Tan, Guangyun

    2016-04-22

    Interferon (IFN) is a regularly utilized therapeutic for the treatment of chronic hepatitis B and appears to induce superior HBeAg seroconversion comparing nucleos/tide analogs. However, the mechanisms underlying IFN inhibition of HBV replication, as well as poor responses to IFN are unclear. Apobec3G has been reported to be involved in regulating HBV replication. In this study, we investigated Apobec3G expression and regulatory pathways during HBV infection. We show that over-expression of A3G leads to inhibition of HBV replication. We also show that IFN induces a significant increase in A3G protein expression, which is associated with STAT3 activation. We further show that A3G expression in HBV patients is lower compared to non-infected controls, possibly by HBsAg which inhibits IFN induced A3G up-regulation in a dose dependent manner. This process is likely mediated through inhibition of STAT3-Ser727 phosphorylation. The results presented in this study indicate that STAT3 plays an important role in IFN-induced A3G production, and HBsAg may correlated with poor response to IFN treatment. PMID:27003258

  4. APOBEC3G inhibits HIV-1 RNA elongation by inactivating the viral trans-activation response element.

    PubMed

    Nowarski, Roni; Prabhu, Ponnandy; Kenig, Edan; Smith, Yoav; Britan-Rosich, Elena; Kotler, Moshe

    2014-07-29

    Deamination of cytidine residues in viral DNA is a major mechanism by which APOBEC3G (A3G) inhibits vif-deficient human immunodeficiency virus type 1 (HIV-1) replication. dC-to-dU transition following RNase-H activity leads to viral cDNA degradation, production of non-functional proteins, formation of undesired stop codons and decreased viral protein synthesis. Here, we demonstrate that A3G provides an additional layer of defense against HIV-1 infection dependent on inhibition of proviral transcription. HIV-1 transcription elongation is regulated by the trans-activation response (TAR) element, a short stem-loop RNA structure required for elongation factors binding. Vif-deficient HIV-1-infected cells accumulate short viral transcripts and produce lower amounts of full-length HIV-1 transcripts due to A3G deamination of the TAR apical loop cytidine, highlighting the requirement for TAR loop integrity in HIV-1 transcription. We further show that free single-stranded DNA (ssDNA) termini are not essential for A3G activity and a gap of CCC motif blocked with juxtaposed DNA or RNA on either or 3'+5' ends is sufficient for A3G deamination. These results identify A3G as an efficient mutator and that deamination of (-)SSDNA results in an early block of HIV-1 transcription. PMID:24859335

  5. APOBEC3G Inhibits HIV-1 RNA Elongation by Inactivating the Viral Trans-Activation Response Element

    PubMed Central

    Nowarski, Roni; Prabhu, Ponnandy; Kenig, Edan; Smith, Yoav; Britan-Rosich, Elena; Kotler, Moshe

    2014-01-01

    Deamination of cytidine residues in viral DNA (vDNA) is a major mechanism by which APOBEC3G (A3G) inhibits vif-deficient HIV-1 replication. dC to dU transition following RNase-H activity leads to viral cDNA degradation, production of non-functional proteins, formation of undesired stop codons and decreased viral protein synthesis. Here we demonstrate that A3G provides an additional layer of defence against HIV-1 infection dependent on inhibition of proviral transcription. HIV-1 transcription elongation is regulated by the trans-activation response (TAR) element, a short stem-loop RNA structure required for elongation factors binding. Vif-deficient HIV-1-infected cells accumulate short viral transcripts and produce lower amounts of full-length HIV-1 transcripts due to A3G deamination of the TAR apical loop cytidine, highlighting the requirement for TAR loop integrity in HIV-1 transcription. Finally, we show that free ssDNA termini are not essential for A3G activity and a gap of CCC motif blocked with juxtaposed DNA or RNA on either or 3′+5′ ends is sufficient for A3G deamination, identifying A3G as an efficient mutator, and that deamination of (−)SSDNA results in an early block of HIV-1 transcription. PMID:24859335

  6. Estimating the fraction of progeny virions that must incorporate APOBEC3G for suppression of productive HIV-1 infection

    SciTech Connect

    Thangavelu, Pulari U.; Gupta, Vipul; Dixit, Narendra M.

    2014-01-20

    The contest between the host factor APOBEC3G (A3G) and the HIV-1 protein Vif presents an attractive target of intervention. The extent to which the A3G–Vif interaction must be suppressed to tilt the balance in favor of A3G remains unknown. We employed stochastic simulations and mathematical modeling of the within-host dynamics and evolution of HIV-1 to estimate the fraction of progeny virions that must incorporate A3G to render productive infection unsustainable. Using three different approaches, we found consistently that a transition from sustained infection to suppression of productive infection occurred when the latter fraction exceeded ∼0.8. The transition was triggered by A3G-induced hypermutations that led to premature stop codons compromising viral production and was consistent with driving the basic reproductive number, R{sub 0}, below unity. The fraction identified may serve as a quantitative guideline for strategies targeting the A3G–Vif axis. - Highlights: • We perform simulations and mathematical modeling of the role of APOBEC3G in suppressing HIV-1 infection. • In three distinct ways, we estimate that when over 80% of progeny virions carry APOBEC3G, productive HIV-1 infection would be suppressed. • Our estimate of this critical fraction presents quantitative guidelines for strategies targeting the APOBEC3G–Vif axis.

  7. Extension of RAPTOR-M3G to r-θ-z Geometry for Use in Reactor Dosimetry Applications

    NASA Astrophysics Data System (ADS)

    Hunter, Melissa A.; Longoni, Gianluca; Anderson, Stanwood L.

    2009-08-01

    The RAPTOR-M3G (RApid Parallel Transport Of Radiation - Multiple 3-D Geometries) is a new deterministic radiation transport code that was originally developed for x-y-z geometry. The development of the r-θ-z version of RAPTOR-M3G and its application to determine ex-vessel neutron dosimetry responses in the cavity of a typical 2-loop pressurized water reactor is presented. The neutron dosimetry responses determined from RAPTOR-M3G and TORT 3-D r-θ-z calculations are compared to actual measured responses.

  8. EEG Changes Due to Experimentally Induced 3G Mobile Phone Radiation

    PubMed Central

    Roggeveen, Suzanne; van Os, Jim; Viechtbauer, Wolfgang; Lousberg, Richel

    2015-01-01

    The aim of this study was to investigate whether a 15-minute placement of a 3G dialing mobile phone causes direct changes in EEG activity compared to the placement of a sham phone. Furthermore, it was investigated whether placement of the mobile phone on the ear or the heart would result in different outcomes. Thirty-one healthy females participated. All subjects were measured twice: on one of the two days the mobile phone was attached to the ear, the other day to the chest. In this single-blind, cross-over design, assessments in the sham phone condition were conducted directly preceding and following the mobile phone exposure. During each assessment, EEG activity and radiofrequency radiation were recorded jointly. Delta, theta, alpha, slowbeta, fastbeta, and gamma activity was computed. The association between radiation exposure and the EEG was tested using multilevel random regression analyses with radiation as predictor of main interest. Significant radiation effects were found for the alpha, slowbeta, fastbeta, and gamma bands. When analyzed separately, ear location of the phone was associated with significant results, while chest placement was not. The results support the notion that EEG alterations are associated with mobile phone usage and that the effect is dependent on site of placement. Further studies are required to demonstrate the physiological relevance of these findings. PMID:26053854

  9. Fish otolith growth in 1g and 3g depends on the gravity vector.

    PubMed

    Anken, R H; Werner, K; Breuer, J; Rahmann, H

    2000-01-01

    Size and asymmetry (size difference between the left and the right side) as well as calcium (Ca) content of inner ear otoliths of larval cichlid fish Oreochromis mossambicus were determined after a long-term stay at hypergravity conditions (3g; centrifuge). Both utricular and saccular otoliths (lapilli and sagittae, respectively) were significantly smaller after hyper-g exposure as compared to parallely raised 1g-control specimens and the absolute amount of otolith-Ca was diminished. The asymmetry of sagittae was significantly increased in the experimental animals, whereas the respective asymmetry concerning lapilli was markedly decreased. In the course of another experiment larvae were raised in aquarium hatch baskets, from which one was placed directly above aeration equipment which resulted in random water circulation shifting the fish around ("shifted" specimens). The lapillar asymmetry of the "stationary" specimens showed a highly significant increase during early development when larvae were forced to lay on their sides due to their prominent yolk-sacs. In later developmental stages, when they began to swim freely, a dramatic decrease in lapillar asymmetry was apparent. Taken together with own previous findings according to which otolith growth stops after vestibular nerve transaction, the results presented here suggest that the growth and the development of bilateral asymmetry of otoliths is guided by the environmental gravity vector, obviously involving a feedback loop between the brain and the inner ear. PMID:11542852

  10. Fish Otolith Growth in 1g and 3g Depends on the Gravity Vector

    NASA Astrophysics Data System (ADS)

    Anken, R. H.; Werner, K.; Breuer, J.; Rahmann, H.

    Size and asymmetry (size difference between the left and the right side) as well as calcium (Ca) content of inner ear otoliths of larval cichlid fish Oreochromis mossambicus were determined after a long-term stay at hypergravity conditions (3g; centrifuge). Both utricular and saccular otoliths (lapilli and sagittae, respectively) were significantly smaller after hyper-g exposure as compared to parallely raised 1g-control specimens and the absolute amount of otolith-Ca was diminished. The asymmetry of sagittae was significantly increased in the experimental animals, whereas the respective asymmetry concerning lapilli was markedly decreased. In the course of another experiment, larvae were raised in aquarium hatch baskets, from which one was placed directly above aeration equipment, which resulted in random water circulation shifting the fish around (``shifted'' specimens). The lapillar asymmetry of the ``stationary'' specimens showed a highly significant increase during early development when larvae were forced to lay on their sides due to their prominent yolk-sacs. In later developmental stages, when they began to swim freely, a dramatic decrease in lapillar asymmetry was apparent. Taken together with own previous findings according to which otolith growth stops after vestibular nerve transection, the results presented here suggest that the growth and the development of bilateral asymmetry of otoliths is guided by the environmental gravity vector, obviously involving a feedback loop between the brain and the inner ear

  11. Morphometry of fish inner ear otoliths after development at 3g hypergravity.

    PubMed

    Anken, R H; Kappel, T; Rahmann, H

    1998-07-01

    Size and asymmetry (size difference between the left and right sides) of inner ear otoliths of larval cichlid fish were determined after a long-term stay in moderate hypergravity conditions (3g; centrifuge), in the course of which the animals completed their ontogenetic development from hatch to freely swimming. Neither the normal morphogenetic development nor the timely onset and gain of performance of swimming behaviour were impaired by the experimental conditions. However, both utricular and saccular otoliths (lapilli and sagittae, respectively) were significantly smaller after hyper-g exposure compared to 1g control specimens raised in parallel. The asymmetry of sagittae was significantly increased in the experimental animals, whereas the respective asymmetry of lapilli was pronouncedly decreased compared with the 1g controls. These findings suggest that growth and development of bilateral asymmetry of otoliths are guided by the environmental gravity vector. Some of the hyper-g animals revealed a kinetotic behaviour on transfer to normal 1g earth conditions, which was similar to the behaviour observed in previous experiments on the transfer from 1g to microgravity (parabolic aircraft flights). The lapillar asymmetry of kinetotic samples was found to be significantly higher than that of normally behaving experimental specimens. No differences in asymmetry of sagittae were obtained between the two groups. This supports an earlier theoretical concept, according to which human static space sickness might be based on asymmetric utricular otoliths. PMID:9726679

  12. Comparison of average global exposure of population induced by a macro 3G network in different geographical areas in France and Serbia.

    PubMed

    Huang, Yuanyuan; Varsier, Nadège; Niksic, Stevan; Kocan, Enis; Pejanovic-Djurisic, Milica; Popovic, Milica; Koprivica, Mladen; Neskovic, Aleksandar; Milinkovic, Jelena; Gati, Azeddine; Person, Christian; Wiart, Joe

    2016-09-01

    This article is the first thorough study of average population exposure to third generation network (3G)-induced electromagnetic fields (EMFs), from both uplink and downlink radio emissions in different countries, geographical areas, and for different wireless device usages. Indeed, previous publications in the framework of exposure to EMFs generally focused on individual exposure coming from either personal devices or base stations. Results, derived from device usage statistics collected in France and Serbia, show a strong heterogeneity of exposure, both in time, that is, the traffic distribution over 24 h was found highly variable, and space, that is, the exposure to 3G networks in France was found to be roughly two times higher than in Serbia. Such heterogeneity is further explained based on real data and network architecture. Among those results, authors show that, contrary to popular belief, exposure to 3G EMFs is dominated by uplink radio emissions, resulting from voice and data traffic, and average population EMF exposure differs from one geographical area to another, as well as from one country to another, due to the different cellular network architectures and variability of mobile usage. Bioelectromagnetics. 37:382-390, 2016. © 2016 Wiley Periodicals, Inc. PMID:27385053

  13. C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development

    PubMed Central

    Shah, Bhavin; Lutter, Daniela; Bochenek, Magdalena L.; Kato, Katsuhiro; Tsytsyura, Yaroslav; Glyvuk, Natalia; Sakakibara, Akira; Klingauf, Jürgen; Adams, Ralf H.; Püschel, Andreas W.

    2016-01-01

    The establishment of a polarized morphology is essential for the development and function of neurons. During the development of the mammalian neocortex, neurons arise in the ventricular zone (VZ) from radial glia cells (RGCs) and leave the VZ to generate the cortical plate (CP). During their migration, newborn neurons first assume a multipolar morphology in the subventricular zone (SVZ) and lower intermediate zone (IZ). Subsequently, they undergo a multi-to-bipolar (MTB) transition to become bipolar in the upper IZ by developing a leading process and a trailing axon. The small GTPases Rap1A and Rap1B act as master regulators of neural cell polarity in the developing mouse neocortex. They are required for maintaining the polarity of RGCs and directing the MTB transition of multipolar neurons. Here we show that the Rap1 guanine nucleotide exchange factor (GEF) C3G (encoded by the Rapgef1 gene) is a crucial regulator of the MTB transition in vivo by conditionally inactivating the Rapgef1 gene in the developing mouse cortex at different time points during neuronal development. Inactivation of C3G results in defects in neuronal migration, axon formation and cortical lamination. Live cell imaging shows that C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process. PMID:27111087

  14. C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development.

    PubMed

    Shah, Bhavin; Lutter, Daniela; Bochenek, Magdalena L; Kato, Katsuhiro; Tsytsyura, Yaroslav; Glyvuk, Natalia; Sakakibara, Akira; Klingauf, Jürgen; Adams, Ralf H; Püschel, Andreas W

    2016-01-01

    The establishment of a polarized morphology is essential for the development and function of neurons. During the development of the mammalian neocortex, neurons arise in the ventricular zone (VZ) from radial glia cells (RGCs) and leave the VZ to generate the cortical plate (CP). During their migration, newborn neurons first assume a multipolar morphology in the subventricular zone (SVZ) and lower intermediate zone (IZ). Subsequently, they undergo a multi-to-bipolar (MTB) transition to become bipolar in the upper IZ by developing a leading process and a trailing axon. The small GTPases Rap1A and Rap1B act as master regulators of neural cell polarity in the developing mouse neocortex. They are required for maintaining the polarity of RGCs and directing the MTB transition of multipolar neurons. Here we show that the Rap1 guanine nucleotide exchange factor (GEF) C3G (encoded by the Rapgef1 gene) is a crucial regulator of the MTB transition in vivo by conditionally inactivating the Rapgef1 gene in the developing mouse cortex at different time points during neuronal development. Inactivation of C3G results in defects in neuronal migration, axon formation and cortical lamination. Live cell imaging shows that C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process. PMID:27111087

  15. A single immunization with recombinant rabies virus (ERAG3G) confers complete protection against rabies in mice

    PubMed Central

    2014-01-01

    Purpose New alternative bait rabies vaccines applicable to pet dogs and wild animals are needed to eradicate rabies in Korea. In this study, recombinant rabies virus, ERAG3G strain was constructed using reverse genetic system and the safety, efficacy and immunogenicity of the ERAG3G strain was evaluated in mice and dogs. Materials and Methods Using the full-length genome mutated amino acid at position 333 of glycoprotein of rabies virus (RABV) and helper plasmids, the ERAG3G strain was rescued in BHK/T7-9 cells successfully. Mice were inoculated with the ERAG3G strain for safety and efficacy. Safety and immunogenicity of the dog inoculated with the ERAG3G strain (1 mL, 108.0 FAID50/mL) via intramuscular route was evaluated for 28 days after inoculation. Results The ERAG3G strain rescued by reverse genetic system was propagated well in the mouse neuroblastoma cells revealing titer of 108.5 FAID50/mL and was not pathogenic to 4- or 6-week-old mice that received by intramuscular or intracranical route. Immunization with the ERAG3G strain conferred complete protection from lethal RABV in mice. Dogs inoculated with the vaccine candidate via intramuscular route showed high neutralizing antibody titer ranging from 2.62 to 23.9 IU/mL at 28 days postinoculation. Conclusion Our findings suggest that the ERAG3G strain plays an important role in inducing protective efficacy in mice and causes to arise anti-rabies neutralizing antibody in dogs. PMID:25003091

  16. A Non-Stationary 1981-2012 AVHRR NDVI(sub 3g) Time Series

    NASA Technical Reports Server (NTRS)

    Pinzon, Jorge E.; Tucker, Compton J.

    2014-01-01

    The NDVI(sub 3g) time series is an improved 8-km normalized difference vegetation index (NDVI) data set produced from Advanced Very High Resolution Radiometer (AVHRR) instruments that extends from 1981 to the present. The AVHRR instruments have flown or are flying on fourteen polar-orbiting meteorological satellites operated by the National Oceanic and Atmospheric Administration (NOAA) and are currently flying on two European Organization for the Exploitation of Meteorological Satellites (EUMETSAT) polar-orbiting meteorological satellites, MetOp-A and MetOp-B. This long AVHRR record is comprised of data from two different sensors: the AVHRR/2 instrument that spans July 1981 to November 2000 and the AVHRR/3 instrument that continues these measurements from November 2000 to the present. The main difficulty in processing AVHRR NDVI data is to properly deal with limitations of the AVHRR instruments. Complicating among-instrument AVHRR inter-calibration of channels one and two is the dual gain introduced in late 2000 on the AVHRR/3 instruments for both these channels. We have processed NDVI data derived from the Sea-Viewing Wide Field-of-view Sensor (SeaWiFS) from 1997 to 2010 to overcome among-instrument AVHRR calibration difficulties. We use Bayesian methods with high quality well-calibrated SeaWiFS NDVI data for deriving AVHRR NDVI calibration parameters. Evaluation of the uncertainties of our resulting NDVI values gives an error of plus or minus 0.005 NDVI units for our 1981 to present data set that is independent of time within our AVHRR NDVI continuum and has resulted in a non-stationary climate data set.

  17. ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction

    PubMed Central

    Miyakawa, Kei; Matsunaga, Satoko; Kanou, Kazuhiko; Matsuzawa, Atsushi; Morishita, Ryo; Kudoh, Ayumi; Shindo, Keisuke; Yokoyama, Masaru; Sato, Hironori; Kimura, Hirokazu; Tamura, Tomohiko; Yamamoto, Naoki; Ichijo, Hidenori; Takaori-Kondo, Akifumi; Ryo, Akihide

    2015-01-01

    APOBEC3G (A3G) is an innate antiviral restriction factor that strongly inhibits the replication of human immunodeficiency virus type 1 (HIV-1). An HIV-1 accessory protein, Vif, hijacks the host ubiquitin–proteasome system to execute A3G degradation. Identification of the host pathways that obstruct the action of Vif could provide a new strategy for blocking viral replication. We demonstrate here that the host protein ASK1 (apoptosis signal-regulating kinase 1) interferes with the counteraction by Vif and revitalizes A3G-mediated viral restriction. ASK1 binds the BC-box of Vif, thereby disrupting the assembly of the Vif–ubiquitin ligase complex. Consequently, ASK1 stabilizes A3G and promotes its incorporation into viral particles, ultimately reducing viral infectivity. Furthermore, treatment with the antiretroviral drug AZT (zidovudine) induces ASK1 expression and restores the antiviral activity of A3G in HIV-1-infected cells. This study thus demonstrates a distinct function of ASK1 in restoring the host antiviral system that can be enhanced by AZT treatment. PMID:25901786

  18. Nuclear distribution of eIF3g and its interacting nuclear proteins in breast cancer cells

    PubMed Central

    ZHENG, QIAOLI; LIU, HAO; YE, JINGJIA; ZHANG, HUI; JIA, ZHENYU; CAO, JIANG

    2016-01-01

    Eukaryotic translation initiation factor 3 subunit g (eIF3g) is a core subunit of the eukaryotic translation initiation factor 3 complex, and is important in the initiation of translation. It is also involved in caspase-mediated apoptosis, and is upregulated in multidrug-resistant cancer cells. In the present study, the nuclear distribution of eIF3g was determined by performing co-immunoprecipitation of proteins that potentially interact with eIF3g in the nucleus. Mass spectrometry characterization showed that three proteins, heterogeneous nuclear ribonucleoprotein U/scaffold attachment factor A, HSZFP36/zinc finger protein 823 and β-actin, were among the candidate eIF3g-interacting proteins in the nucleus. The protein-protein interaction was further confirmed by cross-linking and a glutathione S-transferase pull-down assay, followed by western blotting. The co-localization of these proteins was determined by confocal microscopy. These findings provide novel insight into the possible functions of eIF3g in the nucleus and serves as an important first step for further investigation of the roles of eIF3g in cancer development. PMID:26935993

  19. First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G

    SciTech Connect

    Li, Ming; Shandilya, Shivender M.D.; Carpenter, Michael A.; Rathore, Anurag; Brown, William L.; Perkins, Angela L.; Harki, Daniel A.; Solberg, Jonathan; Hook, Derek J.; Pandey, Krishan K.; Parniak, Michael A.; Johnson, Jeffrey R.; Krogan, Nevan J.; Somasundaran, Mohan; Ali, Akbar; Schiffer, Celia A.; Harris, Reuben S.

    2012-04-04

    APOBEC3G is a single-stranded DNA cytosine deaminase that comprises part of the innate immune response to viruses and transposons. Although APOBEC3G is the prototype for understanding the larger mammalian polynucleotide deaminase family, no specific chemical inhibitors exist to modulate its activity. High-throughput screening identified 34 compounds that inhibit APOBEC3G catalytic activity. Twenty of 34 small molecules contained catechol moieties, which are known to be sulfhydryl reactive following oxidation to the orthoquinone. Located proximal to the active site, C321 was identified as the binding site for the inhibitors by a combination of mutational screening, structural analysis, and mass spectrometry. Bulkier substitutions C321-to-L, F, Y, or W mimicked chemical inhibition. A strong specificity for APOBEC3G was evident, as most compounds failed to inhibit the related APOBEC3A enzyme or the unrelated enzymes E. coli uracil DNA glycosylase, HIV-1 RNase H, or HIV-1 integrase. Partial, but not complete, sensitivity could be conferred to APOBEC3A by introducing the entire C321 loop from APOBEC3G. Thus, a structural model is presented in which the mechanism of inhibition is both specific and competitive, by binding a pocket adjacent to the APOBEC3G active site, reacting with C321, and blocking access to substrate DNA cytosines.

  20. The Significance of Parents' and Grandparents' Role. Proceedings of the Fenno-Hungarian Conference on Developmental Psychology (3rd, Lahti, Finland, July 11-13, 1993).

    ERIC Educational Resources Information Center

    Kalliopuska, Mirja, Ed.

    The third Fenno-Hungarian Conference on Developmental Psychology covered four main concepts: the historical roots and development of social competence through three generations, parent-child interaction, parenthood, and the development of socio-cognitive competence through childhood and adolescence. A series of papers was presented addressing the…

  1. Personality of Teacher in Advanced Socialist Society. Collection of Papers from the Conference of Educationalists of Socialist Countries (3rd, Warsaw, Poland, June 1977).

    ERIC Educational Resources Information Center

    Tmej, K., Ed.; Petracek, S., Ed.

    A need for concerted efforts in devising a more profound socialist education for the younger generation, and a strengthening of ideological ties joining the socialist nations was revealed in conference papers on: (1) the conference's significance (K. Tmej); (2) inaugural address (J. Kuberski); (3) Marxism-Leninism on the task of schools and…

  2. The Vaporization of B2O3(l) to B2O3(g) and B2O2(g)

    NASA Technical Reports Server (NTRS)

    Jacobson, Nathan S.; Myers, Dwight L.

    2011-01-01

    The vaporization of B2O3 in a reducing environment leads to formation of both B2O3(g) and B2O2(g). While formation of B2O3(g) is well understood, many questions about the formation of B2O2(g) remain. Previous studies using B(s) + B2O3(l) have led to inconsistent thermodynamic data. In this study, it was found that after heating, B(s) and B2O3(l) appear to separate and variations in contact area likely led to the inconsistent vapor pressures of B2O2(g). To circumvent this problem, an activity of boron is fixed with a two-phase mixture of FeB and Fe2B. Both second and third law enthalpies of formation were measured for B2O2(g) and B2O3(g). From these the enthalpies of formation at 298.15 K are calculated to be -479.9 +/- 41.5 kJ/mol for B2O2(g) and -833.4 +/- 13.1 kJ/mol for B2O3(g). Ab initio calculations to determine the enthalpies of formation of B2O2(g) and B2O3(g) were conducted using the W1BD composite method and show good agreement with the experimental values.

  3. Multi-Phase Flow and Heat Transfer Symposium-Workshop, 3rd, Miami Beach, FL, April 18-20, 1983, Proceedings of Condensed Papers

    NASA Astrophysics Data System (ADS)

    Veziroglu, T. N.

    Attempts at analytical predictions of stable operating regimes for multi-phase flows are reported, together with experimental results. The fundamentals and regimes of multi-phase flows are explored, including the behavior of bubbles in liquid flows. Attention is given to incidences of flow pressure drop and heat transfer properties in air-water dispersed flow, during blowdown, and in MHD flows. Mass transfer and phase changes conditions are investigated in turbulent flows, in the cockpit environment, and in the formation of alloys. Consideration is given to boiling and condensation phenomena on surfaces, in pools, and in tubes and fins, and to instabilities and turbulence. Reactor safety is discussed, as are numerical models for multi-phase flow, steam generation and distribution with solar and geothermal heat sources, and characteristics of transients and wave propagation. Fluidized bed flows are examined, together with measurement techniques and the characteristics of suspensions. No individual items are abstracted in this volume

  4. Soviet-West German Symposium on Heat Transfer in Cryogenic Systems, 3rd, Kharkov, Ukrainian SSR, Oct. 9-11, 1989, Proceedings

    NASA Astrophysics Data System (ADS)

    1990-04-01

    The papers presented in this volume describe a rotating cryostat for the simulation of mechanical, thermal, and hydraulic processes in superconducting rotors; the problems of cooling the fully superconducting generator stator; an investigation of natural circulation by optical methods; and a method of calculating void fraction for vapor-liquid or gas-liquid flow conditions. Attention is given to an experimental study of the processes of He-3 boiling and condensation, heat transfer in He II at a slow variation of the heat load, an investigation of He II flow crisis in porous media, and cryogenic heat pipes. Other papers are on the stability of rotating superconducting windings for electric machines, the stability of high-temperature superconductors cooled by liquid nitrogen, a calculation of the transpiration cooling of a cylindrical porous wall, and pressure losses in boiling nitrogen flow through horizontal channels.

  5. Knee-ligament loading properties as influenced by gravity. I - Junction with bone of 3-G rodents

    NASA Technical Reports Server (NTRS)

    Wunder, C. C.; Matthes, R. D.; Tipton, C. M.

    1982-01-01

    The effect of 3-G conditions on the bone-to-ligament junctions of the knee is studied in rats. Results following chronic 3-G centrifugation of rats show that their bone-to-ligament junctions exhibited a force-sustaining capacity (F) which was 95 + or - 12% of the value for the control group. However, F was actually 29 + or - 5% greater for centrifuged rats than for control rats of comparable size, as the experimental animals grew to smaller body mass. It is concluded that gravity determines part of the magnitude of F, and therefore this value will probably be weaker after development in a weightless environment.

  6. All Roads Lead to Rome: Exploring Human Migration to the Eternal City through Biochemistry of Skeletons from Two Imperial-Era Cemeteries (1st-3rd c AD).

    PubMed

    Killgrove, Kristina; Montgomery, Janet

    2016-01-01

    Migration within the Roman Empire occurred at multiple scales and was engaged in both voluntarily and involuntarily. Because of the lengthy tradition of classical studies, bioarchaeological analyses must be fully contextualized within the bounds of history, material culture, and epigraphy. In order to assess migration to Rome within an updated contextual framework, strontium isotope analysis was performed on 105 individuals from two cemeteries associated with Imperial Rome-Casal Bertone and Castellaccio Europarco-and oxygen and carbon isotope analyses were performed on a subset of 55 individuals. Statistical analysis and comparisons with expected local ranges found several outliers who likely immigrated to Rome from elsewhere. Demographics of the immigrants show men and children migrated, and a comparison of carbon isotopes from teeth and bone samples suggests the immigrants may have significantly changed their diet. These data represent the first physical evidence of individual migrants to Imperial Rome. This case study demonstrates the importance of employing bioarchaeology to generate a deeper understanding of a complex ancient urban center. PMID:26863610

  7. All Roads Lead to Rome: Exploring Human Migration to the Eternal City through Biochemistry of Skeletons from Two Imperial-Era Cemeteries (1st-3rd c AD)

    PubMed Central

    Killgrove, Kristina; Montgomery, Janet

    2016-01-01

    Migration within the Roman Empire occurred at multiple scales and was engaged in both voluntarily and involuntarily. Because of the lengthy tradition of classical studies, bioarchaeological analyses must be fully contextualized within the bounds of history, material culture, and epigraphy. In order to assess migration to Rome within an updated contextual framework, strontium isotope analysis was performed on 105 individuals from two cemeteries associated with Imperial Rome—Casal Bertone and Castellaccio Europarco—and oxygen and carbon isotope analyses were performed on a subset of 55 individuals. Statistical analysis and comparisons with expected local ranges found several outliers who likely immigrated to Rome from elsewhere. Demographics of the immigrants show men and children migrated, and a comparison of carbon isotopes from teeth and bone samples suggests the immigrants may have significantly changed their diet. These data represent the first physical evidence of individual migrants to Imperial Rome. This case study demonstrates the importance of employing bioarchaeology to generate a deeper understanding of a complex ancient urban center. PMID:26863610

  8. 3rd College of paediatrics and child health lecture--the past, the present and the shape of things to come...

    PubMed

    Loke, Kah Yin; Lin, Jeremy By; Mabel, Deurenberg Yap

    2008-05-01

    The growth trends of Singapore children spanning 5 decades are reviewed, based on 8 anthropometric studies from 1957 till 2002. The heights of pre-school children and school age children appear to have optimised according to their genetic potential, but the weights and body mass indices of children still appear to be increasing from 6 to 18 years for both sexes, probably as a consequence of increasing affluence. This trend is reflected in the increasing obesity prevalence in school children over the past 30 years, and the concomitant increased morbidity associated with the metabolic syndrome, necessitates further research into the causes of obesity. Barker's hypothesis first suggested that changes in the intra-uterine environment can cause fetal adaptations which persist into adulthood, and are responsible for many chronic diseases of adult life. More recently, intense research in the field of epigenetics suggests that the environment can also influence the phenotype through gene expression, through modification of DNA methylation and histones which, in turn, influences gene expression. The challenge for the future is to determine if there are clear epigenetic changes, which are responsible for the increased prevalence of childhood and adolescent obesity, and whether these changes are transmitted through generations. Unravelling these epigenetic mechanisms may be the key to the prevention of obesity and the metabolic syndrome. PMID:18536833

  9. Rotating machinery - Transport phenomena; Proceedings of the 3rd International Symposium on Transport Phenomena and Dynamics of Rotating Machinery (ISROMAC-3), Honolulu, HI, Apr. 1-4, 1990

    NASA Astrophysics Data System (ADS)

    Kim, J. H.; Yang, W.-J.

    Topics discussed in these proceedings include turbine cooling heat transfer, rotating surfaces, curved ducts and rotating channels, flow in pumps, analytical and numerical methods, design and design methods, and multiphase flow and cavitation. Papers are presented on transient heat analysis of stator in air-cooled turbine generators, numerical evaluation of single central jet for turbine disk cooling, film condensation on a rotating cone, flows of a gas in an abruptly rotating cylinder, developing turbulent flow in a curved duct with strong secondary motion, effects of turn region treatments on pressure loss through sharp 180-deg bends, and examination of inlet surging in centrifugal pumps. Particular attention is given to the prediction of viscous flows in rotating machinery using Navier-Stokes techniques, two-dimensional transonic flow around VKI turbine cascade, the dynamic transfer matrix of a pump and its use in pumping system design, a fast CAE/CAD procedure for the optimum design of arbitrary impellers, particle dynamics and erosion in radial turbine guide vanes, sustained oscillations of pumped two-phase flow in a closed loop, and rotor/stator flow coupling in turbomachines.

  10. Rotating machinery - Transport phenomena; Proceedings of the 3rd International Symposium on Transport Phenomena and Dynamics of Rotating Machinery (ISROMAC-3), Honolulu, HI, Apr. 1-4, 1990

    SciTech Connect

    Kim, J.H.; Yang, W.J.

    1992-01-01

    Topics discussed in these proceedings include turbine cooling heat transfer, rotating surfaces, curved ducts and rotating channels, flow in pumps, analytical and numerical methods, design and design methods, and multiphase flow and cavitation. Papers are presented on transient heat analysis of stator in air-cooled turbine generators, numerical evaluation of single central jet for turbine disk cooling, film condensation on a rotating cone, flows of a gas in an abruptly rotating cylinder, developing turbulent flow in a curved duct with strong secondary motion, effects of turn region treatments on pressure loss through sharp 180-deg bends, and examination of inlet surging in centrifugal pumps. Particular attention is given to the prediction of viscous flows in rotating machinery using Navier-Stokes techniques, two-dimensional transonic flow around VKI turbine cascade, the dynamic transfer matrix of a pump and its use in pumping system design, a fast CAE/CAD procedure for the optimum design of arbitrary impellers, particle dynamics and erosion in radial turbine guide vanes, sustained oscillations of pumped two-phase flow in a closed loop, and rotor/stator flow coupling in turbomachines.

  11. Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein.

    PubMed

    Chaurasiya, Kathy R; McCauley, Micah J; Wang, Wei; Qualley, Dominic F; Wu, Tiyun; Kitamura, Shingo; Geertsema, Hylkje; Chan, Denise S B; Hertz, Amber; Iwatani, Yasumasa; Levin, Judith G; Musier-Forsyth, Karin; Rouzina, Ioulia; Williams, Mark C

    2014-01-01

    The human APOBEC3 proteins are a family of DNA-editing enzymes that play an important role in the innate immune response against retroviruses and retrotransposons. APOBEC3G is a member of this family that inhibits HIV-1 replication in the absence of the viral infectivity factor Vif. Inhibition of HIV replication occurs by both deamination of viral single-stranded DNA and a deamination-independent mechanism. Efficient deamination requires rapid binding to and dissociation from ssDNA. However, a relatively slow dissociation rate is required for the proposed deaminase-independent roadblock mechanism in which APOBEC3G binds the viral template strand and blocks reverse transcriptase-catalysed DNA elongation. Here, we show that APOBEC3G initially binds ssDNA with rapid on-off rates and subsequently converts to a slowly dissociating mode. In contrast, an oligomerization-deficient APOBEC3G mutant did not exhibit a slow off rate. We propose that catalytically active monomers or dimers slowly oligomerize on the viral genome and inhibit reverse transcription. PMID:24345943

  12. Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid binding protein

    PubMed Central

    Chaurasiya, Kathy R.; McCauley, Micah J.; Wang, Wei; Qualley, Dominic F.; Wu, Tiyun; Kitamura, Shingo; Geertsema, Hylkje; Chan, Denise S.B.; Hertz, Amber; Iwatani, Yasumasa; Levin, Judith G.; Musier-Forsyth, Karin; Rouzina, Ioulia; Williams, Mark C.

    2014-01-01

    The human APOBEC3 proteins are a family of DNA-editing enzymes that play an important role in the innate immune response and have broad activity against retroviruses and retrotransposons. APOBEC3G is a member of this family that inhibits HIV-1 replication in the absence of the viral infectivity factor Vif. Inhibition of HIV replication occurs by both deamination of viral single-stranded DNA and a deamination-independent mechanism. Efficient deamination requires rapid binding to and dissociation from ssDNA. However, a relatively slow dissociation rate is required for the proposed deaminase-independent roadblock mechanism in which APOBEC3G binds the viral template strand and blocks reverse transcriptase-catalyzed DNA elongation. Here we show that APOBEC3G initially binds ssDNA with rapid on-off rates and subsequently converts to a slowly dissociating mode. In contrast, an oligomerization-deficient APOBEC3G mutant did not exhibit a slow off rate. We propose that catalytically active monomers or dimers slowly oligomerize on the viral genome and inhibit reverse transcription. PMID:24345943

  13. Reactor Dosimetry Applications Using RAPTOR-M3G:. a New Parallel 3-D Radiation Transport Code

    NASA Astrophysics Data System (ADS)

    Longoni, Gianluca; Anderson, Stanwood L.

    2009-08-01

    The numerical solution of the Linearized Boltzmann Equation (LBE) via the Discrete Ordinates method (SN) requires extensive computational resources for large 3-D neutron and gamma transport applications due to the concurrent discretization of the angular, spatial, and energy domains. This paper will discuss the development RAPTOR-M3G (RApid Parallel Transport Of Radiation - Multiple 3D Geometries), a new 3-D parallel radiation transport code, and its application to the calculation of ex-vessel neutron dosimetry responses in the cavity of a commercial 2-loop Pressurized Water Reactor (PWR). RAPTOR-M3G is based domain decomposition algorithms, where the spatial and angular domains are allocated and processed on multi-processor computer architectures. As compared to traditional single-processor applications, this approach reduces the computational load as well as the memory requirement per processor, yielding an efficient solution methodology for large 3-D problems. Measured neutron dosimetry responses in the reactor cavity air gap will be compared to the RAPTOR-M3G predictions. This paper is organized as follows: Section 1 discusses the RAPTOR-M3G methodology; Section 2 describes the 2-loop PWR model and the numerical results obtained. Section 3 addresses the parallel performance of the code, and Section 4 concludes this paper with final remarks and future work.

  14. Oligomerization transforms human APOBEC3G from an efficient enzyme to a slowly dissociating nucleic acid-binding protein

    NASA Astrophysics Data System (ADS)

    Chaurasiya, Kathy R.; McCauley, Micah J.; Wang, Wei; Qualley, Dominic F.; Wu, Tiyun; Kitamura, Shingo; Geertsema, Hylkje; Chan, Denise S. B.; Hertz, Amber; Iwatani, Yasumasa; Levin, Judith G.; Musier-Forsyth, Karin; Rouzina, Ioulia; Williams, Mark C.

    2014-01-01

    The human APOBEC3 proteins are a family of DNA-editing enzymes that play an important role in the innate immune response against retroviruses and retrotransposons. APOBEC3G is a member of this family that inhibits HIV-1 replication in the absence of the viral infectivity factor Vif. Inhibition of HIV replication occurs by both deamination of viral single-stranded DNA and a deamination-independent mechanism. Efficient deamination requires rapid binding to and dissociation from ssDNA. However, a relatively slow dissociation rate is required for the proposed deaminase-independent roadblock mechanism in which APOBEC3G binds the viral template strand and blocks reverse transcriptase-catalysed DNA elongation. Here, we show that APOBEC3G initially binds ssDNA with rapid on-off rates and subsequently converts to a slowly dissociating mode. In contrast, an oligomerization-deficient APOBEC3G mutant did not exhibit a slow off rate. We propose that catalytically active monomers or dimers slowly oligomerize on the viral genome and inhibit reverse transcription.

  15. Uracil DNA Glycosylase Is Dispensable for Human Immunodeficiency Virus Type 1 Replication and Does Not Contribute to the Antiviral Effects of the Cytidine Deaminase Apobec3G

    PubMed Central

    Kaiser, Shari M.; Emerman, Michael

    2006-01-01

    It is well established that many host factors are involved in the replication of human immunodeficiency virus (HIV) type 1. One host protein, uracil DNA glycosylase 2 (UNG2), binds to multiple viral proteins and is packaged into HIV type 1 virions. UNG initiates the removal of uracils from DNA, and this has been proposed to be important both for reverse transcription and as a mediator to the antiviral effect of virion-incorporated Apobec3G, a cytidine deaminase that generates numerous uracils in the viral DNA during virus replication. We used a natural human UNG−/− cell line as well as cells that express a potent catalytic active-site inhibitor of UNG to assess the effects of removing UNG activity on HIV infectivity. In both cases, we find UNG2 activity and protein to be completely dispensable for virus replication. Moreover, we find that virion-associated UNG2 does not affect the loss of infectivity caused by Apobec3G. PMID:16378989

  16. Mixing and turbulent mixing in fluids, plasma and materials: summary of works presented at the 3rd International Conference on Turbulent Mixing and Beyond

    NASA Astrophysics Data System (ADS)

    Gauthier, Serge; Keane, Christopher J.; Niemela, Joseph J.; Abarzhi, Snezhana I.

    2013-07-01

    was held in the summer of 2011 at the Abdus Salam International Centre for Theoretical Physics (ICTP), Trieste, Italy. The papers are arranged by TMB themes, and within each theme they are ordered alphabetically by the last name of the first author. The collection includes regular research papers, a few research briefs and review papers. The review papers are published as 'Comments' articles in Physica Scripta . Canonical turbulence and turbulent mixing. Six papers are devoted to canonical turbulence and turbulent mixing. Baumert presents a theory of shear-generated turbulence, which is based on a two-fluid concept. Gampert et al investigate the problem of adequate representation of turbulent structures by applying a decomposition of the field of the turbulent kinetic energy into regions of compressive and extensive strain. Paul and Narashima consider the dynamics of a temporal mixing layer using a vortex sheet model. Schaefer et al analyse the joint statistics and conditional mean strain rates of streamline segments in turbulent flows. Sirota and Zybin deepen their discussion of the connection between Lagrangian and Eulerian velocity structure functions in hydrodynamic turbulence. Talbot et al investigate the heterogeneous mixing by considering gases of very nearly equal densities and very different viscosities. Wall-bounded flows. Three papers are dedicated to wall-bounded flows. Mok et al use the Bayesian spectral density approach to identify the dominant free surface fluctuation frequency downstream of an oscillating hydraulic jump. Tejada-Martinez et al employ large eddy numerical simulations to study wind-driven shallow water flows with and without full-depth Langmuir circulation (parallel counter rotating vortices). Wu et al re-evaluate the Karman constant based on a multi-layer analytical theory of Prandtl's mixing length function. Non-equilibrium processes. This theme is represented by two papers. Chasheckhin and Zagumennyi consider non-equilibrium processes

  17. PREFACE: MEM05: The 3rd International Workshop on Mechano-Electromagnetic Properties of Composite Superconductors (Kyoto, Japan, 17 20 July 2005)

    NASA Astrophysics Data System (ADS)

    Osamura, Kozo; Hampshire, Damian

    2005-12-01

    One of the important challenges facing the international scientific community at the beginning of the third millennium is how to manage the world's energy resources properly. Superconductivity will provide one of the strategies employed to avoid an energy crisis. Of course the ITER Fusion Tokomak that is to be built in France provides an exciting focus for the whole superconductivity community. In parallel, we can expect that other key technologies for superconductivity such as large capacity transmission cables, energy storage systems, and generators and motors will have a real impact in technologically advanced countries. There is broadly a consensus that the prototype stage for high-current high-field superconducting applications is largely completed, and the required performance has been demonstrated. However, before we move to full industrialization of large-scale superconducting technologies, feasibility studies suggest there are two types of problem that remain. The first is the development of high performance and low cost materials which are fully optimized in terms of critical current, low ac loss and high strength. The second is the establishment of optimal procedures for system design accompanying scale up. As the system design is dependent on material development, there is a critical need to study the key issues for developing high performance superconducting materials. Under the activities of the NEDO Grant Project (Applied Superconductivity), MEM05 was organized by Professor Osamura (Kyoto University), Professor Itoh (NIMS), Professor Hojo (Kyoto University) and Professor Matsumoto (Kyoto University) and held in Kyoto, Japan. The focus for the workshop was the elimination of grain boundary weak links, the creation of strong flux pinning sites, the optimal arrangement of filaments and barriers for reducing ac losses, and the design of high strength strain tolerant composite conductors. Five subsessions were held at MEM05. • Mechanical properties of

  18. Influence of the Packet Size on the One-Way Delay in 3G Networks

    NASA Astrophysics Data System (ADS)

    Arlos, Patrik; Fiedler, Markus

    We currently observe a rising interest in mobile broadband, which users expect to perform in a similar way as its fixed counterpart. On the other hand, the capacity allocation process on mobile access links is far less transparent to the user; still, its properties need to be known in order to minimize the impact of the network on application performance. This paper investigates the impact of the packet size on the minimal one-way delay for the uplink in third-generation mobile networks. For interactive and real-time applications such as VoIP, one-way delays are of major importance for user perception; however, they are challenging to measure due to their sensitivity to clock synchronisation. Therefore, the paper applies a robust and innovative method to assure the quality of these measurements. Results from measurements from several Swedish mobile operators show that applications can gain significantly in terms of one-way delay from choosing optimal packet sizes. We show that, in certain cases, an increased packet size can improve the one-way delay performance at best by several hundred milliseconds.

  19. Mixing and turbulent mixing in fluids, plasma and materials: summary of works presented at the 3rd International Conference on Turbulent Mixing and Beyond

    NASA Astrophysics Data System (ADS)

    Gauthier, Serge; Keane, Christopher J.; Niemela, Joseph J.; Abarzhi, Snezhana I.

    2013-07-01

    was held in the summer of 2011 at the Abdus Salam International Centre for Theoretical Physics (ICTP), Trieste, Italy. The papers are arranged by TMB themes, and within each theme they are ordered alphabetically by the last name of the first author. The collection includes regular research papers, a few research briefs and review papers. The review papers are published as 'Comments' articles in Physica Scripta . Canonical turbulence and turbulent mixing. Six papers are devoted to canonical turbulence and turbulent mixing. Baumert presents a theory of shear-generated turbulence, which is based on a two-fluid concept. Gampert et al investigate the problem of adequate representation of turbulent structures by applying a decomposition of the field of the turbulent kinetic energy into regions of compressive and extensive strain. Paul and Narashima consider the dynamics of a temporal mixing layer using a vortex sheet model. Schaefer et al analyse the joint statistics and conditional mean strain rates of streamline segments in turbulent flows. Sirota and Zybin deepen their discussion of the connection between Lagrangian and Eulerian velocity structure functions in hydrodynamic turbulence. Talbot et al investigate the heterogeneous mixing by considering gases of very nearly equal densities and very different viscosities. Wall-bounded flows. Three papers are dedicated to wall-bounded flows. Mok et al use the Bayesian spectral density approach to identify the dominant free surface fluctuation frequency downstream of an oscillating hydraulic jump. Tejada-Martinez et al employ large eddy numerical simulations to study wind-driven shallow water flows with and without full-depth Langmuir circulation (parallel counter rotating vortices). Wu et al re-evaluate the Karman constant based on a multi-layer analytical theory of Prandtl's mixing length function. Non-equilibrium processes. This theme is represented by two papers. Chasheckhin and Zagumennyi consider non-equilibrium processes

  20. 78 FR 958 - Certain Wireless Devices With 3G and/or 4G Capabilities and Components Thereof Notice of Receipt...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-07

    ... COMMISSION Certain Wireless Devices With 3G and/or 4G Capabilities and Components Thereof Notice of Receipt... Commission has received a complaint entitled Certain Wireless Devices with 3G and/or 4G Capabilities and... importation, and the sale within the United States after importation of certain wireless devices with 3g...

  1. SonTek SL3G Side-Looking Doppler Current Meter application in Complex Flow Conditions

    NASA Astrophysics Data System (ADS)

    Wagenaar, D.

    2014-12-01

    The SonTek Argonaut SL Side-Looking Doppler Current Meters are well established products in the measurement of real-time water velocity in open channels. With the development of acoustic doppler technology the decision was made to incorporate latest technology in the Argonaut SL and hence the SonTek SL3G was born.The SonTek SL3G Acoustic Doppler instrument incorporates a number of innovations that improves velocity measurements and quality assurance of data for Side-Looking Doppler Current Meters. SmartPulseHD was originally introduced with the launch of the SonTek M9/S5 RiverSurveyor Acoustic Doppler Instruments and the increased accuracy and resolution of velocity measurements made it obvious to include into the new SL3G instruments. SmartPulseHD continuously tracks the water conditions and selects the optimum processing configuration required using multiple ping types and processing techniques. The new SL3G design makes it the smallest Side Looking Acoustic Doppler Velocity Meter on the market reducing flow disturbance caused by the instrument and the distance of first measurement cell from boundary.The application of the SL3G Acoustic Doppler instrument is designed for complex flow conditions where the use of conventional stage-discharge relationships is economically not viable and therefore requires the use of velocity index methodology. The case-study presented in this paper is situated in the Colorado River downstream of Imperial Dam affected by controlled releases, drainage from adjacent irrigation areas and backwater from a weir situated downstream of the monitoring site. The paper analyses the relationship between measured mean velocity and index velocity and if additional variables such as stage and or Y-velocity need to be incorporated in the development of the index velocity rating. In addition, to determine the variables impacting on the index velocity rating, the index velocity applied will be evaluated by the best linear relationship between the

  2. Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference.

    PubMed

    Kirchhof, Paulus; Lip, Gregory Y H; Van Gelder, Isabelle C; Bax, Jeroen; Hylek, Elaine; Kaab, Stefan; Schotten, Ulrich; Wegscheider, Karl; Boriani, Giuseppe; Brandes, Axel; Ezekowitz, Michael; Diener, Hans; Haegeli, Laurent; Heidbuchel, Hein; Lane, Deirdre; Mont, Luis; Willems, Stephan; Dorian, Paul; Aunes-Jansson, Maria; Blomstrom-Lundqvist, Carina; Borentain, Maria; Breitenstein, Stefanie; Brueckmann, Martina; Cater, Nilo; Clemens, Andreas; Dobrev, Dobromir; Dubner, Sergio; Edvardsson, Nils G; Friberg, Leif; Goette, Andreas; Gulizia, Michele; Hatala, Robert; Horwood, Jenny; Szumowski, Lukas; Kappenberger, Lukas; Kautzner, Josef; Leute, Angelika; Lobban, Trudie; Meyer, Ralf; Millerhagen, Jay; Morgan, John; Muenzel, Felix; Nabauer, Michael; Baertels, Christoph; Oeff, Michael; Paar, Dieter; Polifka, Juergen; Ravens, Ursula; Rosin, Ludger; Stegink, W; Steinbeck, Gerhard; Vardas, Panos; Vincent, Alphons; Walter, Maureen; Breithardt, Günter; Camm, A John

    2012-01-01

    While management of atrial fibrillation (AF) patients is improved by guideline-conform application of anticoagulant therapy, rate control, rhythm control, and therapy of accompanying heart disease, the morbidity and mortality associated with AF remain unacceptably high. This paper describes the proceedings of the 3rd Atrial Fibrillation NETwork (AFNET)/European Heart Rhythm Association (EHRA) consensus conference that convened over 60 scientists and representatives from industry to jointly discuss emerging therapeutic and diagnostic improvements to achieve better management of AF patients. The paper covers four chapters: (i) risk factors and risk markers for AF; (ii) pathophysiological classification of AF; (iii) relevance of monitored AF duration for AF-related outcomes; and (iv) perspectives and needs for implementing better antithrombotic therapy. Relevant published literature for each section is covered, and suggestions for the improvement of management in each area are put forward. Combined, the propositions formulate a perspective to implement comprehensive management in AF. PMID:21791573

  3. Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options—a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference

    PubMed Central

    Kirchhof, Paulus; Lip, Gregory Y.H.; Van Gelder, Isabelle C.; Bax, Jeroen; Hylek, Elaine; Kaab, Stefan; Schotten, Ulrich; Wegscheider, Karl; Boriani, Giuseppe; Brandes, Axel; Ezekowitz, Michael; Diener, Hans; Haegeli, Laurent; Heidbuchel, Hein; Lane, Deirdre; Mont, Luis; Willems, Stephan; Dorian, Paul; Aunes-Jansson, Maria; Blomstrom-Lundqvist, Carina; Borentain, Maria; Breitenstein, Stefanie; Brueckmann, Martina; Cater, Nilo; Clemens, Andreas; Dobrev, Dobromir; Dubner, Sergio; Edvardsson, Nils G.; Friberg, Leif; Goette, Andreas; Gulizia, Michele; Hatala, Robert; Horwood, Jenny; Szumowski, Lukas; Kappenberger, Lukas; Kautzner, Josef; Leute, Angelika; Lobban, Trudie; Meyer, Ralf; Millerhagen, Jay; Morgan, John; Muenzel, Felix; Nabauer, Michael; Baertels, Christoph; Oeff, Michael; Paar, Dieter; Polifka, Juergen; Ravens, Ursula; Rosin, Ludger; Stegink, W.; Steinbeck, Gerhard; Vardas, Panos; Vincent, Alphons; Walter, Maureen; Breithardt, Günter; Camm, A. John

    2012-01-01

    While management of atrial fibrillation (AF) patients is improved by guideline-conform application of anticoagulant therapy, rate control, rhythm control, and therapy of accompanying heart disease, the morbidity and mortality associated with AF remain unacceptably high. This paper describes the proceedings of the 3rd Atrial Fibrillation NETwork (AFNET)/European Heart Rhythm Association (EHRA) consensus conference that convened over 60 scientists and representatives from industry to jointly discuss emerging therapeutic and diagnostic improvements to achieve better management of AF patients. The paper covers four chapters: (i) risk factors and risk markers for AF; (ii) pathophysiological classification of AF; (iii) relevance of monitored AF duration for AF-related outcomes; and (iv) perspectives and needs for implementing better antithrombotic therapy. Relevant published literature for each section is covered, and suggestions for the improvement of management in each area are put forward. Combined, the propositions formulate a perspective to implement comprehensive management in AF. PMID:21791573

  4. Crystal Structure of DNA Cytidine Deaminase ABOBEC3G Catalytic Deamination Domain Suggests a Binding Mode of Full-length Enzyme to Single-stranded DNA*

    PubMed Central

    Lu, Xiuxiu; Zhang, Tianlong; Xu, Zeng; Liu, Shanshan; Zhao, Bin; Lan, Wenxian; Wang, Chunxi; Ding, Jianping; Cao, Chunyang

    2015-01-01

    APOBEC3G (A3G) is a DNA cytidine deaminase (CD) that demonstrates antiviral activity against human immunodeficiency virus 1 (HIV-1) and other pathogenic virus. It has an inactive N-terminal CD1 virus infectivity factor (Vif) protein binding domain (A3G-CD1) and an actively catalytic C-terminal CD2 deamination domain (A3G-CD2). Although many studies on the structure of A3G-CD2 and enzymatic properties of full-length A3G have been reported, the mechanism of how A3G interacts with HIV-1 single-stranded DNA (ssDNA) is still not well characterized. Here, we reported a crystal structure of a novel A3G-CD2 head-to-tail dimer (in which the N terminus of the monomer H (head) interacts with the C terminus of monomer T (tail)), where a continuous DNA binding groove was observed. By constructing the A3G-CD1 structural model, we found that its overall fold was almost identical to that of A3G-CD2. We mutated the residues located in or along the groove in monomer H and the residues in A3G-CD1 that correspond to those seated in or along the groove in monomer T. Then, by performing enzymatic assays, we confirmed the reported key elements and the residues in A3G necessary to the catalytic deamination. Moreover, we identified more than 10 residues in A3G essential to DNA binding and deamination reaction. Therefore, this dimer structure may represent a structural model of full-length A3G, which indicates a possible binding mode of A3G to HIV-1 ssDNA. PMID:25542899

  5. Crystal structure of DNA cytidine deaminase ABOBEC3G catalytic deamination domain suggests a binding mode of full-length enzyme to single-stranded DNA.

    PubMed

    Lu, Xiuxiu; Zhang, Tianlong; Xu, Zeng; Liu, Shanshan; Zhao, Bin; Lan, Wenxian; Wang, Chunxi; Ding, Jianping; Cao, Chunyang

    2015-02-13

    APOBEC3G (A3G) is a DNA cytidine deaminase (CD) that demonstrates antiviral activity against human immunodeficiency virus 1 (HIV-1) and other pathogenic virus. It has an inactive N-terminal CD1 virus infectivity factor (Vif) protein binding domain (A3G-CD1) and an actively catalytic C-terminal CD2 deamination domain (A3G-CD2). Although many studies on the structure of A3G-CD2 and enzymatic properties of full-length A3G have been reported, the mechanism of how A3G interacts with HIV-1 single-stranded DNA (ssDNA) is still not well characterized. Here, we reported a crystal structure of a novel A3G-CD2 head-to-tail dimer (in which the N terminus of the monomer H (head) interacts with the C terminus of monomer T (tail)), where a continuous DNA binding groove was observed. By constructing the A3G-CD1 structural model, we found that its overall fold was almost identical to that of A3G-CD2. We mutated the residues located in or along the groove in monomer H and the residues in A3G-CD1 that correspond to those seated in or along the groove in monomer T. Then, by performing enzymatic assays, we confirmed the reported key elements and the residues in A3G necessary to the catalytic deamination. Moreover, we identified more than 10 residues in A3G essential to DNA binding and deamination reaction. Therefore, this dimer structure may represent a structural model of full-length A3G, which indicates a possible binding mode of A3G to HIV-1 ssDNA. PMID:25542899

  6. Lucky guess or knowledge: a cross-sectional study using the Bland and Altman analysis to compare confidence-based testing of pharmacological knowledge in 3rd and 5th year medical students.

    PubMed

    Kampmeyer, Daniela; Matthes, Jan; Herzig, Stefan

    2015-05-01

    Multiple-choice-questions are common in medical examinations, but guessing biases assessment results. Confidence-based-testing (CBT) integrates indicated confidence levels. It has been suggested that correctness of and confidence in an answer together indicate knowledge levels thus determining the quality of a resulting decision. We used a CBT approach to investigate whether decision quality improves during undergraduate medical education. 3rd- and 5th-year students attended formative multiple-choice exams on pharmacological issues. Students were asked to indicate their confidence in a given answer. Correctness of answers was scored binary (1-correct; 0-wrong) and confidence levels were transformed to an ordinal scale (guess: 0; rather unsure: 0.33; rather sure: 0.66; very sure: 1). 5th-year students gave more correct answers (73 ± 16 vs. 49 ± 13 %, p < 0.05) and were on average more confident regarding the correctness of their answers (0.61 ± 0.18 vs. 0.46 ± 0.13, p < 0.05). Correlation of these parameters was stronger for 5th-year students (r = 0.81 vs. r = 0.52), but agreement of confidence and correctness ('centration') was lower. By combining the Bland-and-Altman approach with categories of decision-quality we found that 5th-year students were more likely to be 'well-informed' (41 vs. 5 %), while more 3rd-students were 'uninformed' (24 vs. 76 %). Despite a good correlation of exam results and confidence in given answers increased knowledge might be accompanied by a more critical view at the own abilities. Combining the statistical Bland-and-Altman analysis with a theoretical approach to decision-quality, more advanced students are expected to apply correct beliefs, while their younger fellows are rather at risk to hesitate or to act amiss. PMID:25103688

  7. Feasibility Study on a Portable Field Pest Classification System Design Based on DSP and 3G Wireless Communication Technology

    PubMed Central

    Han, Ruizhen; He, Yong; Liu, Fei

    2012-01-01

    This paper presents a feasibility study on a real-time in field pest classification system design based on Blackfin DSP and 3G wireless communication technology. This prototype system is composed of remote on-line classification platform (ROCP), which uses a digital signal processor (DSP) as a core CPU, and a host control platform (HCP). The ROCP is in charge of acquiring the pest image, extracting image features and detecting the class of pest using an Artificial Neural Network (ANN) classifier. It sends the image data, which is encoded using JPEG 2000 in DSP, to the HCP through the 3G network at the same time for further identification. The image transmission and communication are accomplished using 3G technology. Our system transmits the data via a commercial base station. The system can work properly based on the effective coverage of base stations, no matter the distance from the ROCP to the HCP. In the HCP, the image data is decoded and the pest image displayed in real-time for further identification. Authentication and performance tests of the prototype system were conducted. The authentication test showed that the image data were transmitted correctly. Based on the performance test results on six classes of pests, the average accuracy is 82%. Considering the different live pests’ pose and different field lighting conditions, the result is satisfactory. The proposed technique is well suited for implementation in field pest classification on-line for precision agriculture. PMID:22736996

  8. Feasibility study on a portable field pest classification system design based on DSP and 3G wireless communication technology.

    PubMed

    Han, Ruizhen; He, Yong; Liu, Fei

    2012-01-01

    This paper presents a feasibility study on a real-time in field pest classification system design based on Blackfin DSP and 3G wireless communication technology. This prototype system is composed of remote on-line classification platform (ROCP), which uses a digital signal processor (DSP) as a core CPU, and a host control platform (HCP). The ROCP is in charge of acquiring the pest image, extracting image features and detecting the class of pest using an Artificial Neural Network (ANN) classifier. It sends the image data, which is encoded using JPEG 2000 in DSP, to the HCP through the 3G network at the same time for further identification. The image transmission and communication are accomplished using 3G technology. Our system transmits the data via a commercial base station. The system can work properly based on the effective coverage of base stations, no matter the distance from the ROCP to the HCP. In the HCP, the image data is decoded and the pest image displayed in real-time for further identification. Authentication and performance tests of the prototype system were conducted. The authentication test showed that the image data were transmitted correctly. Based on the performance test results on six classes of pests, the average accuracy is 82%. Considering the different live pests' pose and different field lighting conditions, the result is satisfactory. The proposed technique is well suited for implementation in field pest classification on-line for precision agriculture. PMID:22736996

  9. Fundamentals of nuclear pharmacy, 3rd Ed

    SciTech Connect

    Saha, G.B. )

    1992-01-01

    This book is a standard text/reference of nuclear pharmacy. New sections in the Third Edition include: instruments used for radiation detection and measurement; disposal of radioactive materials; clinical uses of all new and existing radiopharmaceuticals; 99m Tc and 123I-labeled radiopharmaceuticals, as well as radiolabeled leukocytes, platelets, and antibodies; and up-to-date descriptions of the latest FDA regulations.

  10. Cerebral computed tomography, 3rd Edition

    SciTech Connect

    Weisberg, L.; Nice, C.

    1988-01-01

    This book is an introduction to the utilization of computed tomography in evaluating patients with intracranial and orbital disorders. It features clinical correlations and provides an overview of general principles, performance, and normal anatomy of CT. It covers evaluation of specific neurologic signs and symptoms, including stroke, metastatic disease, increased intracranial pressure, head injury, pediatric conditions, and more.

  11. Towards a hydrogen economy. 3rd ed.

    SciTech Connect

    2006-07-15

    The report is a study of the movement towards using hydrogen as a key energy carrier in the future. It takes a look at the current state of hydrogen and addresses the infrastructure requirements needed to make the hydrogen economy a reality. The report offers a detailed look at the move to a hydrogen economy by: Identifying the current status of hydrogen production and use; Discussing the key business drivers of the move towards hydrogen; Discussing the barriers to implementation that stand in the way of a transition; Providing a critical look at whether the hydrogen economy can succeed; Describing the options that exist for a hydrogen infrastructure; Identifying the key government initiatives making the hydrogen economy a reality; Providing company-by-company profiles of automobile manufacturer efforts to develop and commercialize hydrogen vehicles; and Providing profiles of key hydrogen infrastructure manufacturers.

  12. Teaching Visually Impaired Children. 3rd Edition

    ERIC Educational Resources Information Center

    Bishop, Virginia E.

    2004-01-01

    In this exceptional new third edition, the author has retained much of the practical "how to" approach of the previous editions, but adds depth in two dimensions: learning theory and the educational process. This book is "so comprehensive in scope and complete in detail that it would be the most likely recommended" (from the foreword by Dr.…

  13. A Beginning. Revised 3rd Edition.

    ERIC Educational Resources Information Center

    Healy, Mary K.; Root, Phyllis

    This document contains a selection of materials focusing on man acting to know, preserve, and improve his environment. The booklet is divided into three parts. Part one presents a listing of objectives. They reflect a need for all to become aware of the problems that plague our environment. Furthermore, they indicate that the ecological…

  14. Coal mine ground control. 3rd ed.

    SciTech Connect

    Peng, S.S.

    2008-09-15

    The third edition not only completely revises and updates the original subject areas, but also is broadened to include a number of new topics such as high horizontal stresses, computer modeling, and highwall stability. The subject areas covered in this book define the current field of coal mine ground control, except for the recently emerging topic of mine seals and some conventional subjects such as coal/rock cutting and impoundment dams. It contains 1,134 references from all published sources, and archived since 1876.

  15. Elementary Science Guide -- 3rd Grade.

    ERIC Educational Resources Information Center

    Wieland, Anne; And Others

    Presented is a resource book to be used with instructional kits for elementary school science students, grade 3. The individual units at this grade level are based on curriculum which has been developed by the National Science Foundation in the 1960s and revised to meet student and teacher identified needs in Anchorage, Alaska. Six units are…

  16. Presenting the 3rd edition of WRB

    NASA Astrophysics Data System (ADS)

    Schad, Peter

    2014-05-01

    The third edition of the international soil classification system "World Reference Base for Soil Resources" (WRB) will be presented during der 20th World Congress of Soil Science, Jeju, Korea, June 9-12. The second edition was published in 2006 and the first in 1998, which, in turn, was based on the Legends of the FAO Soil Map of the World. Now, after eight years of experience with the second edition, time was due for a revision. The major changes are: 1. The second edition had two different qualifier sequences for naming soils (IUSS Working Group WRB, 2006, update 2007) and for creating map legends (Guidelines for creating small-scale map legends using the WRB; IUSS Working Group WRB, 2010). The third edition has one sequence for both. The qualifiers for every Reference Soil Group are subdivided into a small number of main qualifiers that are ranked and a larger number of additional qualifiers that are not ranked and given in an alphabetical order. The name of a pedon must comprise all applying qualifiers. The name of a map unit comprises a specified small number of main qualifiers, depending on scale, whereas all other qualifiers are optional. 2. For some soils, problems have been reported. Albeluvisols are difficult to detect in the field and cover only small surfaces. They have been replaced by Retisols, which have a broader definition that is easier to identify in the field. 3. The use of some diagnostics was difficult. Examples are: The argic horizon had too low limit values, so we had much more soils with argic horizons than justified. The definitions of the cambic horizon and the gleyic and stagnic properties were not precise enough. Organic material, mollic and umbric horizons had an unnecessary complicated definition. 4. Some changes in the key to the Reference Soil Groups seemed to be justified. Fluvisols were moved further down, Durisols and Gypsisols switched their position, also Arenosols and Cambisols. The soils with an argic horizon were brought into a new sequence. 5. The umbrella function of WRB aims to allow the allocation of soil classes existing in a national classification system within the WRB. Characteristics that in a national system are regarded to be important must be considered in WRB - not necessarily at the highest level, but at least somewhere. The third edition of WRB allows a better accommodation of soil types, e.g., of the Australian and the Brazilian system. 6. Some environments or even ecoregions had not been well represented in WRB. The third edition allows a better accommodation of soils of ultra-continental permafrost regions, acid-sulphate soils and Technosols. 7. How to explain complicated sets of characteristics? For the third edition, efforts were made to give better structured definitions that can be more easily grasped. The editors of the third edition are convinced that the new WRB allows a more precise classification of soils including both, a better naming of pedons and a better elaboration of soil map legends.

  17. The Physics of Glaciers, 3rd Edition

    NASA Astrophysics Data System (ADS)

    Bahr, David

    At one time or another, who among us has not marveled at the beauty of the snow and ice-covered Alps, or admired the tenacity of polar explorers and the adventurous spirits of climbers on the glacier-clad summits of the high Himalaya? The fascination of distant ice covered expanses has enlisted more than a few recruits into the ranks of glaciologists, but many, if not most, of today's students of glaciology are a slightly less romantic and more mathematical lot, attracted by the quantitative world of physics and the applied sciences of polar climatology, ice mechanics, and snow hydrology.Once a relatively quiet branch of geophysics filled with venturesome climbers capable of reaching the objects of their study, glaciology is now a field that is fueled by a rapid influx of talent, technology, and new ideas due to the increasingly acknowledged relationships between global climate, sea level, and ice sheets. While the understanding of glacier processes has seen significant progress, as a result there is also a sense of being overwhelmed by the voluminous and sometimes speculative theories and field observations associated with an expanding discipline.

  18. The 3rd International Microgravity Combustion Workshop

    NASA Technical Reports Server (NTRS)

    Ross, Howard D. (Compiler)

    1995-01-01

    This Conference Publication contains 71 papers presented at the Third International Microgravity Combustion Workshop held in Cleveland, Ohio, from April 11 to 13, 1995. The purpose of the workshop was twofold: to exchange information about the progress and promise of combustion science in microgravity and to provide a forum to discuss which areas in microgravity combustion science need to be expanded profitably and which should be included in upcoming NASA Research Announcements (NRA).

  19. Radiation Therapy Physics, 3rd Edition

    NASA Astrophysics Data System (ADS)

    Hendee, William R.; Ibbott, Geoffrey S.; Hendee, Eric G.

    2004-08-01

    The Third Edition of Radiation Therapy Physics addresses in concise fashion the fundamental diagnostic radiologic physics principles as well as their clinical implications. Along with coverage of the concepts and applications for the radiation treatment of cancer patients, the authors have included reviews of the most up-to-date instrumentation and critical historical links. The text includes coverage of imaging in therapy planning and surveillance, calibration protocols, and precision radiation therapy, as well as discussion of relevant regulation and compliance activities. It contains an updated and expanded section on computer applications in radiation therapy and electron beam therapy, and features enhanced user-friendliness and visual appeal with a new, easy-to-follow format, including sidebars and a larger trim size. With its user-friendly presentation and broad, comprehensive coverage of radiotherapy physics, this Third Edition doubles as a medical text and handy professional reference.

  20. Clear air handbook. 3rd edition

    SciTech Connect

    Brownell, F.W.

    1998-07-01

    The Clean Air Act is the most complex piece of environmental legislation ever enacted, and it is constantly evolving. Regulatory proceedings to implement the act and especially the 1990 amendments are ongoing. Further amendments to the act are being considered by Congress. In addition to developing new rules, EPA also continues to supplement existing rules with guidance documents and policy statements--materials critical to evaluating your company's compliance obligations. This book not only continues to provide a broad overview of all the complex regulatory requirements but also brings you up-to-date on all of the most recent developments. Chapters covered include The Federal-State Partnership; The 1990 Amendments; Air Quality Regulations, State Implementation Plans, and the Non-Attainment Program; Control Technology Regulation; Operating and Pre-Construction Permitting Programs; Acid Deposition Control Program; Hazardous Air Pollutants; Regulation of Mobile Sources of Air Pollution; Stratospheric Ozone Protection; Enforcement and Judicial Review; and Current Regulatory and Legislative Trends.

  1. Library Research Workbook. 3rd Edition, Revised.

    ERIC Educational Resources Information Center

    Hitchings, Donna, Ed.; And Others

    Designed to be used in an English course at the University of Houston, this library skills workbook includes lessons and multiple-choice exercises on the following topics: (1) a floor plan of the main university library; (2) catalog records; (3) catalog access points; (4) using the catalogs; (5) locating books; (6) encyclopedias; (7) dictionaries;…

  2. Peace Corps. 3rd Annual Report.

    ERIC Educational Resources Information Center

    Peace Corps, Washington, DC.

    Projects, operations, and future plans are covered in this annual report for the third year of the Peace Corps. An introduction comments on returning volunteers and presents regional maps with tables for Latin America, Africa, Near East and South Asia, and Far East. Section 1 contains letters and reports from volunteers in Peru, Ivory Coast,…

  3. Dynamical coherent illumination for X-ray microscopy at 3rd generation synchrotron radiation sources: First results with X-rays at the Ca-K edge (4 keV)

    NASA Astrophysics Data System (ADS)

    Oestreich, S.; Rostaing, G.; Niemann, B.; Kaulich, B.; Salomé, M.; Susini, J.; Barrett, R.

    2000-05-01

    Dynamical coherent illumination is a way to deal with the illumination problems which emerge from the use of low emittance sources at recent synchrotron radiation sources for a transmission X-ray microscope (TXM). An illumination system, which uses two rotating mirrors to provide dynamical coherent illumination has been realized and tested at the TXM at ESRF's ID 21 Beamline. First results are presented and compared to results obtained with partial coherent illumination.

  4. Catalytic Analysis of APOBEC3G Involving Real-Time NMR Spectroscopy Reveals Nucleic Acid Determinants for Deamination

    PubMed Central

    Kamba, Keisuke; Nagata, Takashi; Katahira, Masato

    2015-01-01

    APOBEC3G (A3G) is a single-stranded DNA-specific cytidine deaminase that preferentially converts cytidine to uridine at the third position of triplet cytosine (CCC) hotspots. A3G restricts the infectivity of viruses, such as HIV-1, by targeting CCC hotspots scattered through minus DNA strands, reverse-transcribed from genomic RNA. Previously, we developed a real-time NMR method and elucidated the origin of the 3'→5' polarity of deamination of DNA by the C-terminal domain of A3G (CD2), which is a phenomenon by which a hotspot located closer to the 5'-end is deaminated more effectively than one less close to the 5'-end, through quantitative analysis involving nonspecific binding to and sliding along DNA. In the present study we applied the real-time NMR method to analyze the catalytic activity of CD2 toward DNA oligonucleotides containing a nucleotide analog at a single or multiple positions. Analyses revealed the importance of the sugar and base moieties throughout the consecutive 5 nucleotides, the CCC hotspot being positioned at the center. It was also shown that the sugar or base moieties of the nucleotides outside this 5 nucleotide recognition sequence are also relevant as to CD2's activity. Analyses involving DNA oligonucleotides having two CCC hotspots linked by a long sequence of either deoxyribonucleotides, ribonucleotides or abasic deoxyribonucleotides suggested that the phosphate backbone is required for CD2 to slide along the DNA strand and to exert the 3'→5' polarity. Examination of the effects of different salt concentrations on the 3'→5' polarity indicated that the higher the salt concentration, the less prominent the 3'→5' polarity. This is most likely the result of alleviation of sliding due to a decrease in the affinity of CD2 with the phosphate backbone at high salt concentrations. We also investigated the reactivity of substrates containing 5-methylcytidine (5mC) or 5-hydroxymethylcytidine, and found that A3G exhibited low activity toward

  5. Increased expression with differential subcellular location of cytidine deaminase APOBEC3G in human CD4(+) T-cell activation and dendritic cell maturation.

    PubMed

    Oliva, Harold; Pacheco, Rodrigo; Martinez-Navio, José M; Rodríguez-García, Marta; Naranjo-Gómez, Mar; Climent, Núria; Prado, Carolina; Gil, Cristina; Plana, Montserrat; García, Felipe; Miró, José M; Franco, Rafael; Borras, Francesc E; Navaratnam, Naveenan; Gatell, José M; Gallart, Teresa

    2016-08-01

    APOBEC3G (apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G; A3G) is an innate defense protein showing activity against retroviruses and retrotransposons. Activated CD4(+) T cells are highly permissive for HIV-1 replication, whereas resting CD4(+) T cells are refractory. Dendritic cells (DCs), especially mature DCs, are also refractory. We investigated whether these differences could be related to a differential A3G expression and/or subcellular distribution. We found that A3G mRNA and protein expression is very low in resting CD4(+) T cells and immature DCs, but increases strongly following T-cell activation and DC maturation. The Apo-7 anti-A3G monoclonal antibody (mAb), which was specifically developed, confirmed these differences at the protein level and disclosed that A3G is mainly cytoplasmic in resting CD4(+) T cells and immature DCs. Nevertheless, A3G translocates to the nucleus in activated-proliferating CD4(+) T cells, yet remaining cytoplasmic in matured DCs, a finding confirmed by immunoblotting analysis of cytoplasmic and nuclear fractions. Apo-7 mAb was able to immunoprecipitate endogenous A3G allowing to detect complexes with numerous proteins in activated-proliferating but not in resting CD4(+) T cells. The results show for the first time the nuclear translocation of A3G in activated-proliferating CD4(+) T cells. PMID:26987686

  6. The C3G/Rap1 pathway promotes secretion of MMP-2 and MMP-9 and is involved in serous ovarian cancer metastasis.

    PubMed

    Che, Ya-Ling; Luo, Shu-Juan; Li, Gang; Cheng, Min; Gao, Yi-Meng; Li, Xue-Mei; Dai, Jie-Min; He, Huan; Wang, Jin; Peng, Hui-Juan; Zhang, Yu; Li, Wen-Yan; Wang, Hui; Liu, Bin; Linghu, Hua

    2015-04-10

    Complete resection is pivotal to improve survival to epithelial ovarian cancer (EOC). Crk SH3-domain-binding guanine nucleotide-releasing factor (C3G) is involved in multiple signaling pathways and it has opposite roles in different cancers. The present study aimed to identify C3G expression in ovarian tissue samples from patients with EOC and to explore its association with tumor grade. Eighty-seven archival paraffin-embedded, formalin-fixed, ovarian cancer tissues with serous histology were stained for C3G by immunohistochemistry. To evaluate the contribution of C3G to Rap1 activity, 36 patients with serous ovarian cancer (SOC) were investigated. Additionally, C3G was knocked down in SKOV3 and HEY cells. C3G regulated Rap1 activity and high Rap1 activity was correlated with poor differentiation, advanced FIGO stage, and unsuccessful cytoreductive surgery of SOC. Knockdown of C3G suppressed cell invasion, intravasation and extravasation, and reduced Rap1 activity and secretion of matrix metalloproteinase (MMP)-2 and MMP-9. C3G-mediated activation of Rap1 could direct the tumor pattern of human SOC by promoting the secretion of MMP-2 and MMP-9. These results suggest that C3G is involved in the metastatic spread of EOC. PMID:25617801

  7. Advanced IRFPAs for next-generation sensors

    NASA Astrophysics Data System (ADS)

    Caulfield, John T.; Fletcher, Christopher L.; Graham, Roger W.; Patten, Elizabeth A.; Pham, Le T.; Pierce, Gregory; Scribner, Dean A.; Skele, Martins; Taylor, Scott M.; Trautfield, Walter C.

    2004-08-01

    Raytheon Vision Systems (RVS) has invented and demonstrated a new class of advanced focal plane arrays. These Advanced FPAs are sometimes called 3rd Generation or "Next Generation" FPAs because they have integrated onto the FPA the ability to sense multiple IR spectrums, have improved resolution and performance, and conduct image processing on the FPA ROIC. These next generation of FPAs are allowing more functionality and the detection of a more diverse set of data than previously possible with 2nd Gen FPAs. Examples and history of advanced next generation FPAs are reviewed including RVS"s Multispectral, Uncooled, Adaptive Sensors and other advanced sensors.

  8. Assessing change in diet and biological affinity between the 4th and 3rd millennia cal BCE in the Portuguese Estremadura: a preliminary dental comparison of Feteira II and Bolores.

    PubMed

    Horwath, B C; Waterman, A J; Lillios, K T; Irish, J D

    2014-04-01

    Although the social and political changes accompanying the transition from the Neolithic through Copper Age, between the 4th and 3rd millennia cal BCE, in southwestern Iberia are reasonably well understood, much less is known about whether population movements and dietary changes accompanied these transformations. To address this question, human dental remains from the Middle through Late Neolithic site of Feteira II (3600-2900 cal BCE) and the Late Neolithic site of Bolores (2800-2600 cal BCE) in the Portuguese Estremadura were used to examine diet (microwear) and affinity (dental non-metrics). Microwear features were not found to be significantly different between Feteira II and Bolores, suggesting that the emergence of social complexity during this period did not result in large-scale changes in subsistence practices during the period of use at these sites. Using the Arizona State University Dental Anthropology System and supporting statistics, no significant difference between the samples from Feteira II and Bolores was observed, suggesting that no population replacement occurred between the Middle Neolithic and Late Neolithic/Copper Age. However, at Bolores there is some indication that there may have been demographic exchanges between southern Iberian and North African populations during the Late Neolithic/Copper Age. PMID:24642202

  9. Costs, affordability, and feasibility of an essential package of cancer control interventions in low-income and middle-income countries: key messages from Disease Control Priorities, 3rd edition.

    PubMed

    Gelband, Hellen; Sankaranarayanan, Rengaswamy; Gauvreau, Cindy L; Horton, Susan; Anderson, Benjamin O; Bray, Freddie; Cleary, James; Dare, Anna J; Denny, Lynette; Gospodarowicz, Mary K; Gupta, Sumit; Howard, Scott C; Jaffray, David A; Knaul, Felicia; Levin, Carol; Rabeneck, Linda; Rajaraman, Preetha; Sullivan, Terrence; Trimble, Edward L; Jha, Prabhat

    2016-05-21

    Investments in cancer control--prevention, detection, diagnosis, surgery, other treatment, and palliative care--are increasingly needed in low-income and particularly in middle-income countries, where most of the world's cancer deaths occur without treatment or palliation. To help countries expand locally appropriate services, Cancer (the third volume of nine in Disease Control Priorities, 3rd edition) developed an essential package of potentially cost-effective measures for countries to consider and adapt. Interventions included in the package are: prevention of tobacco-related cancer and virus-related liver and cervical cancers; diagnosis and treatment of early breast cancer, cervical cancer, and selected childhood cancers; and widespread availability of palliative care, including opioids. These interventions would cost an additional US$20 billion per year worldwide, constituting 3% of total public spending on health in low-income and middle-income countries. With implementation of an appropriately tailored package, most countries could substantially reduce suffering and premature death from cancer before 2030, with even greater improvements in later decades. PMID:26578033

  10. Current practice of epidemiology in Africa: highlights of the 3rd conference of the African epidemiological association and 1st conference of the Cameroon society of epidemiology, Yaoundé, Cameroon, 2014

    PubMed Central

    Nkwescheu, Armand Seraphin; Fokam, Joseph; Tchendjou, Patrice; Nji, Akindeh; Ngouakam, Hermann; Andre, Bita Fouda; Joelle, Sobngwi; Uzochukwu, Benjamin; Akinroye, Kingsley; Mbacham, Wilfred; Colizzi, Vittorio; Leke, Rose; Victora, Cesar

    2015-01-01

    As the study of disease occurrence and health indicators in human populations, Epidemiology is a dynamic field that evolves with time and geographical context. In order to update African health workers on current epidemiological practices and to draw awareness of early career epidemiologists on concepts and opportunities in the field, the 3rd African Epidemiology Association and the 1st Cameroon Society of Epidemiology Conference was organized in June 2-6, 2014 at the Yaoundé Mont Febe Hotel, in Cameroon. Under the theme«Practice of Epidemiology in Africa: Stakes, Challenges and Perspectives», the conference attracted close to five hundred guest and participants from all continents. The two main programs were the pre-conference course for capacity building of African Early Career epidemiologists, and the conference itself, providing a forum for scientific exchanges on recent epidemiological concepts, encouraging the use of epidemiological methods in studying large disease burden and neglected tropical diseases; and highlighting existing opportunities. PMID:26523191

  11. Report on the 3'rd scientific meeting of the "Verein zur Förderung des Wissenschaftlichen Nachwuchses in der Neurologie" (NEUROWIND e.V.) held in Motzen, Germany, Nov. 4'th - Nov. 6'th, 2011

    PubMed Central

    2012-01-01

    From November 4th- 6th 2011, the 3rd NEUROWIND e.V. meeting was held in Motzen, Brandenburg, Germany. Like in the previous years, the meeting provided an excellent platform for scientific exchange and the presentation of innovative projects for young colleagues in the fields of neurovascular research, neuroinflammation and neurodegeneration. As kick-off to the scientific sessions, Reinhard Hohlfeld, Head of the Institute for Clinical Neuroimmunology in Munich, gave an illustrious overview on the many fascinations of neuroimmunologic research. A particular highlight on the second day of the meeting was the award of the 1'st NEUROWIND e.V. prize for young academics in the field of experimental neurology. This award is posted for young colleagues under the age of 35 with a significant achievement in the field of neurovascular research, neuroinflammation or neurodegeneration and comprises an amount of 20.000 Euro, founded by Merck Serono GmbH, Darmstadt. Germany. The first prize was awarded to Ivana Nikic from Martin Kerschensteiner's group in Munich for her brilliant work on a reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis, published in Nature Medicine in 2011. This first prize award ceremony was a great incentive for the next call for proposals now upcoming in 2012. PMID:22360825

  12. A Hydrodynamic Analysis of APOBEC3G Reveals a Monomer-Dimer-Tetramer Self-Association that has Implications for Anti-HIV Function†

    PubMed Central

    Salter, Jason D.; Krucinska, Jolanta; Raina, Jay; Smith, Harold C.; Wedekind, Joseph E.

    2009-01-01

    The innate antiviral factor APOBEC3G (A3G) possesses RNA binding activity and deaminates HIV-1 DNA. High-molecular-mass forms of A3G can be isolated from a variety of cell types, but exhibit limited deaminase activity relative to low-molecular-mass species prepared under RNA-depleted conditions. To investigate the fundamental oligomeric state and shape of A3G, we conducted sedimentation velocity analyses of the pure enzyme under RNA-deficient conditions. The results reveal a predominant dimer in equilibrium with minor monomeric and tetrameric species. Hydrodynamic modeling of the dimer supports an extended cylindrical shape that assembles into an elongated tetramer. Overall, the results provide physical restraints for the A3G quaternary structure that have implications for modulating antiviral function. PMID:19839647

  13. Evaluation of the effect of a 3rd GnRH injection administered six days after the 2nd GnRH injection of Ovsynch on the reproductive performance of Japanese black cows

    PubMed Central

    Gaja, Abdurraouf Omar; Hamana, Katsumi; Kojima, Toshiyuki

    2008-01-01

    This study was designed to evaluate the reproductive performance of Japanese black cows following the 3rd injection of gonadotropin releasing hormone (GnRH) analogue administered concurrently with Ovsynch-based treatment on day 6 (day 1 = the day of ovulation). In Experiment 1, 12 cows were allocated into three groups: a control group that was subjected to Ovsynch treatment and then injected with a placebo on day 6; group 1 (Ovsynch + GnRH), which was subjected to Ovsynch treatment and was injected with GnRH analogue on day 6, and group 2 (Ovsynch + controlled internal drug-release (CIDR) + GnRH), which received Ovsynch-CIDR treatment and was injected with GnRH analogue on day 6. Blood collection and ultrasonographic observation of the ovaries were conducted daily. Both treatments induced the formation of an accessory corpus luteum and significantly increased the cross-sectional area of the luteal tissue when compared to the control. However, plasma progesterone (P4) was significantly higher in the treatment groups than in the control group on days 11, 12, 17 and 18 in the group 1 and from day 10 to 21 in the group 2. In Experiment 2, 41 cows were assigned to the same three groups described above and then artificially inseminated on day 1. The pregnancy rates on day 45 did not differ among groups. In conclusion, administration of GnRH analogue on day 6 following Ovsynch-based treatment did not improve the reproductive performance of Japanese black cows, even though the P4 concentration was higher in groups that received the GnRH. PMID:18716447

  14. Reg3g overexpression promotes β cell regeneration and induces immune tolerance in nonobese-diabetic mouse model.

    PubMed

    Xia, Fei; Cao, Hui; Du, Jiao; Liu, Xiulan; Liu, Yang; Xiang, Ming

    2016-06-01

    The regenerating islet-derived gene was first isolated in regenerated pancreas tissues, greatly contributing to β cell regeneration. It is an anti-inflammatory in response to cellular stress. This encouraged us to investigate the exact role of a novel member of Reg family, regenerating islet-derived gene γ, in type 1 diabetes of nonobese-diabetic mice. For this, Reg3g gene was overexpressed in pancreatic islets, and conferred beneficial effects on β cell regeneration through activating the Janus kinase 2/signal transducer and activator of transcription 3/nuclear factor κB signaling pathway. Lentiviral vector-encoding regenerating islet-derived gene γ treatment also decreased lymphocyte infiltrates of the intra-islet and peri-islet by inducing both differentiation of regulatory T cell and immature dendritic cells of tolerogenic properties, which attenuated autoimmunity. This treatment further contributed to rebalanced levels of type 1/2 helper T cell cytokines and elevated α1-antitrypsin levels in the serum. These results were not observed in phosphate-buffered saline-treated mice or in lentivirus-control mice. We have shown, for the first time, to our knowledge, that regenerating islet-derived gene γ promotes β cell regeneration and preserves β cells from autoimmunity damage by increasing regulatory T cell differentiation and inducing tolerated dendritic cells. This regenerating islet-derived gene γ infusion could probably be developed into an optimal gene therapy for the prevention and reversal of type 1 diabetes. PMID:26667474

  15. Decolorization of the anthraquinone dye Cibacron Blue 3G-A with immobilized Coprinus cinereus in fluidized bed bioreactor.

    PubMed

    Moutaouakkil, A; Blaghen, M

    2011-01-01

    Coprinus cinereus, which was able to decolorize the anthraquinone dye Cibacron Blue 3G-A (CB) enzymatically, was used as a biocatalyst for the decolorization of synthetic solutions containing this reactive dye. Coprinus cinereus was immobilized in both calcium alginate and polyacrylamide gels, and was used for the decolorization of CB from synthetic water by using a fluidized bed bioreactor. The highest specific decolorization rate was obtained when Coprinus cinereus was entrapped in calcium alginate beads, and was of about 3.84 mg g(-1) h(-1) with a 50% conversion time (t1/2) of about 2.60 h. Moreover, immobilized fungal biomass in calcium alginate continuously decolorized CB even after 7 repeated experiments without significant loss of activity, while polyacrylamide-immobilized fungal biomass retained only 67% of its original activity. The effects of some physicochemical parameters such as temperature, pH and dye concentration on decolorization performance of isolated fungal strain were also investigated. PMID:21438473

  16. VizieR Online Data Catalog: ISOCAM survey of Serpens/G3-G6 (Djupvik+, 2006)

    NASA Astrophysics Data System (ADS)

    Djupvik, A. A.; Andre, P.; Bontemps, S.; Motte, F.; Olofsson, G.; Gaalfalk, M.; Floren, H.-G.

    2006-08-01

    We present results from an ISOCAM survey in the two broadband filters LW2 (5-8.5um) and LW3 (12-18um) of a 19'x16' field called Serp_NH3 centred on the optical group Serpens/G3-G6. A total of 186 sources were detected in the 6.7um band and/or the 14.3um band to a limiting sensitivity of ~2mJy. These have been cross-correlated with the 2MASS catalogue and are all listed in table1. Deep follow-up photometry in the Ks band obtained with Arnica at the Nordic Optical Telescope (NOT) is listed in table2. Deep L' band photometry of selected sources using SIRCA at the NOT is listed in table3. Continuum emission at 1.3mm and 3.6cm was observed with IRAM and VLA, respectively, and deep imaging in the 2.12um S(1) line of H2 was obtained with NOTCam at the NOT. We find strong evidence for a stellar population of 31 Class II sources (listed in table5), 5 flat-spectrum sources, 5 Class I sources (listed in table4), and two Class 0 sources. Our method does not sample the Class III sources. (3 data files).

  17. SensorWeb 3G: Extending On-Orbit Sensor Capabilities to Enable Near Realtime User Configurability

    NASA Technical Reports Server (NTRS)

    Mandl, Daniel; Cappelaere, Pat; Frye, Stuart; Sohlberg, Rob; Ly, Vuong; Chien, Steve; Tran, Daniel; Davies, Ashley; Sullivan, Don; Ames, Troy; Witt, Ken; Stanley, Jason

    2010-01-01

    This research effort prototypes an implementation of a standard interface, Web Coverage Processing Service (WCPS), which is an Open Geospatial Consortium(OGC) standard, to enable users to define, test, upload and execute algorithms for on-orbit sensor systems. The user is able to customize on-orbit data products that result from raw data streaming from an instrument. This extends the SensorWeb 2.0 concept that was developed under a previous Advanced Information System Technology (AIST) effort in which web services wrap sensors and a standardized Extensible Markup Language (XML) based scripting workflow language orchestrates processing steps across multiple domains. SensorWeb 3G extends the concept by providing the user controls into the flight software modules associated with on-orbit sensor and thus provides a degree of flexibility which does not presently exist. The successful demonstrations to date will be presented, which includes a realistic HyspIRI decadal mission testbed. Furthermore, benchmarks that were run will also be presented along with future demonstration and benchmark tests planned. Finally, we conclude with implications for the future and how this concept dovetails into efforts to develop "cloud computing" methods and standards.

  18. Femur-bending properties as influenced by gravity. I - Ultimate load and moment for 3-G rats

    NASA Technical Reports Server (NTRS)

    Wunder, C. C.; Welch, R. C.; Glade, R.; Fleming, B. P.; Cook, K. M.

    1977-01-01

    Fresh experimental bones can withstand greater bending forces and moments after 1.0 to 2.5 weeks of 3-G exposure. This appears more attributable to a 50% greater strength of bone material than to effects upon size or shape, and is most measurable for animals of 5 to 8 weeks of age. Experimental bone material seems to grow to its mature level at a younger age rather then there being so marked an effect upon the mature level itself. We simulated 3.1 G by chronic centrifugation of 66 albino rats and compared them to 63 1-G controls. Extrapolation of the simplest mathematical description of the present results to weaker, zero-G bones could be tested by a total of 60 space-based control and experimental animals. A flight of only 15 animals would be necessary for comparison to ground-based control animals. This is consistent with reports of bone demineralization during space-flight. In light of the differences in bone histology, however, extrapolation of these results to humans would be premature and, if at all applicable, are most likely to be so for children rather than adults.

  19. Tumultuous Relationship between the Human Immunodeficiency Virus Type 1 Viral Infectivity Factor (Vif) and the Human APOBEC-3G and APOBEC-3F Restriction Factors

    PubMed Central

    Henriet, Simon; Mercenne, Gaëlle; Bernacchi, Serena; Paillart, Jean-Christophe; Marquet, Roland

    2009-01-01

    Summary: The viral infectivity factor (Vif) is dispensable for human immunodeficiency virus type 1 (HIV-1) replication in so-called permissive cells but is required for replication in nonpermissive cell lines and for pathogenesis. Virions produced in the absence of Vif have an aberrant morphology and an unstable core and are unable to complete reverse transcription. Recent studies demonstrated that human APOBEC-3G (hA3G) and APOBEC-3F (hA3F), which are selectively expressed in nonpermissive cells, possess strong anti-HIV-1 activity and are sufficient to confer a nonpermissive phenotype. Vif induces the degradation of hA3G and hA3F, suggesting that its main function is to counteract these cellular factors. Most studies focused on the hypermutation induced by the cytidine deaminase activity of hA3G and hA3F and on their Vif-induced degradation by the proteasome. However, recent studies suggested that several mechanisms are involved both in the antiviral activity of hA3G and hA3F and in the way Vif counteracts these antiviral factors. Attempts to reconcile the studies involving Vif in virus assembly and stability with these recent findings suggest that hA3G and hA3F partially exert their antiviral activity independently of their catalytic activity by destabilizing the viral core and the reverse transcription complex, possibly by interfering with the assembly and/or maturation of the viral particles. Vif could then counteract hA3G and hA3F by excluding them from the viral assembly intermediates through competition for the viral genomic RNA, by regulating the proteolytic processing of Pr55Gag, by enhancing the efficiency of the reverse transcription process, and by inhibiting the enzymatic activities of hA3G and hA3F. PMID:19487726

  20. Tumultuous relationship between the human immunodeficiency virus type 1 viral infectivity factor (Vif) and the human APOBEC-3G and APOBEC-3F restriction factors.

    PubMed

    Henriet, Simon; Mercenne, Gaëlle; Bernacchi, Serena; Paillart, Jean-Christophe; Marquet, Roland

    2009-06-01

    The viral infectivity factor (Vif) is dispensable for human immunodeficiency virus type 1 (HIV-1) replication in so-called permissive cells but is required for replication in nonpermissive cell lines and for pathogenesis. Virions produced in the absence of Vif have an aberrant morphology and an unstable core and are unable to complete reverse transcription. Recent studies demonstrated that human APOBEC-3G (hA3G) and APOBEC-3F (hA3F), which are selectively expressed in nonpermissive cells, possess strong anti-HIV-1 activity and are sufficient to confer a nonpermissive phenotype. Vif induces the degradation of hA3G and hA3F, suggesting that its main function is to counteract these cellular factors. Most studies focused on the hypermutation induced by the cytidine deaminase activity of hA3G and hA3F and on their Vif-induced degradation by the proteasome. However, recent studies suggested that several mechanisms are involved both in the antiviral activity of hA3G and hA3F and in the way Vif counteracts these antiviral factors. Attempts to reconcile the studies involving Vif in virus assembly and stability with these recent findings suggest that hA3G and hA3F partially exert their antiviral activity independently of their catalytic activity by destabilizing the viral core and the reverse transcription complex, possibly by interfering with the assembly and/or maturation of the viral particles. Vif could then counteract hA3G and hA3F by excluding them from the viral assembly intermediates through competition for the viral genomic RNA, by regulating the proteolytic processing of Pr55(Gag), by enhancing the efficiency of the reverse transcription process, and by inhibiting the enzymatic activities of hA3G and hA3F. PMID:19487726

  1. Specific absorption rate variation in a brain phantom due to exposure by a 3G mobile phone: problems in dosimetry.

    PubMed

    Behari, J; Nirala, Jay Prakash

    2013-12-01

    A specific absorption rate (SAR) measurements system has been developed for compliance testing of personal mobile phone in a brain phantom material contained in a Perspex box. The volume of the box has been chosen corresponding to the volume of a small rat and illuminated by a 3G mobile phone frequency (1718.5 MHz), and the emitted radiation directed toward brain phantom .The induced fields in the phantom material are measured. Set up to lift the plane carrying the mobile phone is run by a pulley whose motion is controlled by a stepper motor. The platform is made to move at a pre-determined rate of 2 degrees per min limited up to 20 degrees. The measured data for induced fields in various locations are used to compute corresponding SAR values and inter comparison obtained. These data are also compared with those when the mobile phone is placed horizontally with respect to the position of the animal. The SAR data is also experimentally obtained by measuring a rise in temperature due to this mobile exposures and data compared with those obtained in the previous set. To seek a comparison with the safety criteria same set of measurements are performed in 10 g phantom material contained in a cubical box. These results are higher than those obtained with the knowledge of induced field measurements. It is concluded that SAR values are sensitive to the angular position of the moving platform and are well below the safety criteria prescribed for human exposure. The data are suggestive of having a fresh look to understand the mode of electromagnetic field -bio interaction. PMID:24579373

  2. The influence of leaf-atmosphere NH3(g ) exchange on the isotopic composition of nitrogen in plants and the atmosphere.

    PubMed

    Johnson, Jennifer E; Berry, Joseph A

    2013-10-01

    The distribution of nitrogen isotopes in the biosphere has the potential to offer insights into the past, present and future of the nitrogen cycle, but it is challenging to unravel the processes controlling patterns of mixing and fractionation. We present a mathematical model describing a previously overlooked process: nitrogen isotope fractionation during leaf-atmosphere NH3(g ) exchange. The model predicts that when leaf-atmosphere exchange of NH3(g ) occurs in a closed system, the atmospheric reservoir of NH3(g ) equilibrates at a concentration equal to the ammonia compensation point and an isotopic composition 8.1‰ lighter than nitrogen in protein. In an open system, when atmospheric concentrations of NH3(g ) fall below or rise above the compensation point, protein can be isotopically enriched by net efflux of NH3(g ) or depleted by net uptake. Comparison of model output with existing measurements in the literature suggests that this process contributes to variation in the isotopic composition of nitrogen in plants as well as NH3(g ) in the atmosphere, and should be considered in future analyses of nitrogen isotope circulation. The matrix-based modelling approach that is introduced may be useful for quantifying isotope dynamics in other complex systems that can be described by first-order kinetics. PMID:23452149

  3. Contribution of APOBEC3G/F activity to the development of low-abundance drug-resistant human immunodeficiency virus type 1 variants.

    PubMed

    Noguera-Julian, M; Cozzi-Lepri, A; Di Giallonardo, F; Schuurman, R; Däumer, M; Aitken, S; Ceccherini-Silberstein, F; D'Arminio Monforte, A; Geretti, A M; Booth, C L; Kaiser, R; Michalik, C; Jansen, K; Masquelier, B; Bellecave, P; Kouyos, R D; Castro, E; Furrer, H; Schultze, A; Günthard, H F; Brun-Vezinet, F; Metzner, K J; Paredes, R

    2016-02-01

    Plasma drug-resistant minority human immunodeficiency virus type 1 variants (DRMVs) increase the risk of virological failure to first-line non-nucleoside reverse transcriptase inhibitor antiretroviral therapy (ART). The origin of DRMVs in ART-naive patients, however, remains unclear. In a large pan-European case-control study investigating the clinical relevance of pre-existing DRMVs using 454 pyrosequencing, the six most prevalent plasma DRMVs detected corresponded to G-to-A nucleotide mutations (V90I, V106I, V108I, E138K, M184I and M230I). Here, we evaluated if such DRMVs could have emerged from apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3G/F (APOBEC3G/F) activity. Out of 236 ART-naive subjects evaluated, APOBEC3G/F hypermutation signatures were detected in plasma viruses of 14 (5.9%) individuals. Samples with minority E138K, M184I, and M230I mutations, but not those with V90I, V106I or V108I, were significantly associated with APOBEC3G/F activity (Fisher's P < 0.005), defined as the presence of > 0.5% of sample sequences with an APOBEC3G/F signature. Mutations E138K, M184I and M230I co-occurred in the same sequence as APOBEC3G/F signatures in 3/9 (33%), 5/11 (45%) and 4/8 (50%) of samples, respectively; such linkage was not found for V90I, V106I or V108I. In-frame STOP codons were observed in 1.5% of all clonal sequences; 14.8% of them co-occurred with APOBEC3G/F signatures. APOBEC3G/F-associated E138K, M184I and M230I appeared within clonal sequences containing in-frame STOP codons in 2/3 (66%), 5/5 (100%) and 4/4 (100%) of the samples. In a re-analysis of the parent case control study, the presence of APOBEC3G/F signatures was not associated with virological failure. In conclusion, the contribution of APOBEC3G/F editing to the development of DRMVs is very limited and does not affect the efficacy of non-nucleoside reverse transcriptase inhibitor ART. PMID:26482266

  4. Genetic and functional characterization of HIV-1 Vif on APOBEC3G degradation: First report of emergence of B/C recombinants from North India

    PubMed Central

    Ronsard, Larance; Raja, Rameez; Panwar, Vaishali; Saini, Sanjesh; Mohankumar, Kumaravel; Sridharan, Subhashree; Padmapriya, Ramamoorthy; Chaudhuri, Suhnrita; Ramachandran, Vishnampettai G; Banerjea, Akhil C

    2015-01-01

    HIV-1 is characterized by high genetic heterogeneity which is a challenge for developing therapeutics. Therefore, it is necessary to understand the extent of genetic variations that HIV is undergoing in North India. The objective of this study was to determine the role of genetic and functional role of Vif on APOBEC3G degradation. Vif is an accessory protein involved in counteracting APOBEC3/F proteins. Genetic analysis of Vif variants revealed that Vif C variants were closely related to South African Vif C whereas Vif B variants and Vif B/C showed distinct geographic locations. This is the first report to show the emergence of Vif B/C in our population. The functional domains, motifs and phosphorylation sites were well conserved. Vif C variants differed in APOBEC3G degradation from Vif B variants. Vif B/C revealed similar levels of APOBEC3G degradation to Vif C confirming the presence of genetic determinants in C-terminal region. High genetic diversity was observed in Vif variants which may cause the emergence of more complex and divergent strains. These results reveal the genetic determinants of Vif in mediating APOBEC3G degradation and highlight the genetic information for the development of anti-viral drugs against HIV. Importance: Vif is an accessory HIV-1 protein which plays significant role in the degradation of human DNA-editing factor APOBEC3G, thereby impeding the antiretroviral activity of APOBEC3G. It is known that certain natural polymorphisms in Vif could degrade APOBEC3G relatively higher rate, suggesting its role in HIV-1 pathogenesis. This is the first report from North India showcasing genetic variations and novel polymorphisms in Vif gene. Subtype C is prevalent in India, but for the first time we observed putative B/C recombinants with a little high ability to degrade APOBEC3G indicating adaptation and evolving nature of virus in our population. Indian Vif C variants were able to degrade APOBEC3G well in comparison to Vif B variants. These

  5. Structure at 1.6 Å resolution of the protein from gene locus At3g22680 from Arabidopsis thaliana

    PubMed Central

    Allard, Simon T. M.; Bingman, Craig A.; Johnson, Kenneth A.; Wesenberg, Gary E.; Bitto, Eduard; Jeon, Won Bae; Phillips, George N.

    2005-01-01

    The gene product of At3g22680 from Arabidopsis thaliana codes for a protein of unknown function. The crystal structure of the At3g22680 gene product was determined by multiple-wavelength anomalous diffraction and refined to an R factor of 16.0% (R free = 18.4%) at 1.60 Å resolution. The refined structure shows one monomer in the asymmetric unit, with one molecule of the non-denaturing detergent CHAPS {3-[(3-cholamidopropyl)dimethylammonio]-1-propane sulfon­ate} tightly bound. Protein At3g22680 shows no structural homology to any other known proteins and represents a new fold in protein conformation space. PMID:16511118

  6. APOBEC3G mRNA expression in exposed seronegative and early stage HIV infected individuals decreases with removal of exposure and with disease progression

    PubMed Central

    Vázquez-Pérez, Joel A; Ormsby, Christopher E; Hernández-Juan, Ramón; Torres, Klintsy J; Reyes-Terán, Gustavo

    2009-01-01

    Background APOBEC3G is an antiretroviral factor that acts by inducing G to A mutations. In this study, we examined the expression of APOBEC3G in uninfected HIV-1 exposed individuals at the time of their partner's diagnosis and one year later. We then compared this expression with that of infected individuals at different disease stages. APOBEC3G mRNA was measured in PBMCs from three groups: healthy controls with no known risk factor to HIV infection (n = 26), exposed uninfected individuals who had unprotected sex with their HIV+ partners for at least 3 months (n = 37), and HIV infected patients at various disease stages (n = 45), including 8 patients with low HIV viral loads < 10,000 copies/mL (LVL) for at least 3 years. Additionally, we obtained sequences from the env, gag, pol, nef, vif and the LTR of the patients' virus. Results Exposed uninfected individuals expressed higher APOBEC3G than healthy controls (3.86 vs. 1.69 relative expression units), and their expression significantly decreased after a year from the HIV diagnosis and subsequent treatment of their partners. Infected individuals showed a positive correlation (Rho = 0.57, p = 0.00006) of APOBEC3G expression with CD4+ T cell count, and a negative correlation with HIV viremia (Rho = -0.54, p = 0.00004). The percentage of G to A mutations had a positive correlation (Rho = 0.43, p = 0.0226) with APOBEC3G expression, and it was higher in LVL individuals than in the other patients (IQR 8.27 to 9.64 vs. 7.06 to 8.1, p = 0.0084). Out of 8 LVLs, 3 had hypermutations, and 4 had premature stop codons only in viral vif. Conclusion The results suggest that exposure to HIV may trigger APOBEC3G expression in PBMCs, in the absence of infection. Additionally, cessation of exposure or advanced disease is associated with decreased APOBEC3G expression. PMID:19254362

  7. Advanced Structural Analyses by Third Generation Synchrotron Radiation Powder Diffraction

    SciTech Connect

    Sakata, M.; Aoyagi, S.; Ogura, T.; Nishibori, E.

    2007-01-19

    Since the advent of the 3rd generation Synchrotron Radiation (SR) sources, such as SPring-8, the capabilities of SR powder diffraction increased greatly not only in an accurate structure refinement but also ab initio structure determination. In this study, advanced structural analyses by 3rd generation SR powder diffraction based on the Large Debye-Scherrer camera installed at BL02B2, SPring-8 is described. Because of high angular resolution and high counting statistics powder data collected at BL02B2, SPring-8, ab initio structure determination can cope with a molecular crystals with 65 atoms including H atoms. For the structure refinements, it is found that a kind of Maximum Entropy Method in which several atoms are omitted in phase calculation become very important to refine structural details of fairy large molecule in a crystal. It should be emphasized that until the unknown structure is refined very precisely, the obtained structure by Genetic Algorithm (GA) or some other ab initio structure determination method using real space structural knowledge, it is not possible to tell whether the structure obtained by the method is correct or not. In order to determine and/or refine crystal structure of rather complicated molecules, we cannot overemphasize the importance of the 3rd generation SR sources.

  8. Crystal structure of the protein At3g01520, a eukaryotic universal stress protein-like protein from Arabidopsis thaliana in complex with AMP.

    PubMed

    Kim, Do Jin; Bitto, Eduard; Bingman, Craig A; Kim, Hyun-Jung; Han, Byung Woo; Phillips, George N

    2015-07-01

    Members of the universal stress protein (USP) family are conserved in a phylogenetically diverse range of prokaryotes, fungi, protists, and plants and confer abilities to respond to a wide range of environmental stresses. Arabidopsis thaliana contains 44 USP domain-containing proteins, and USP domain is found either in a small protein with unknown physiological function or in an N-terminal portion of a multi-domain protein, usually a protein kinase. Here, we report the first crystal structure of a eukaryotic USP-like protein encoded from the gene At3g01520. The crystal structure of the protein At3g01520 was determined by the single-wavelength anomalous dispersion method and refined to an R factor of 21.8% (Rfree = 26.1%) at 2.5 Å resolution. The crystal structure includes three At3g01520 protein dimers with one AMP molecule bound to each protomer, comprising a Rossmann-like α/β overall fold. The bound AMP and conservation of residues in the ATP-binding loop suggest that the protein At3g01520 also belongs to the ATP-binding USP subfamily members. PMID:25921306

  9. Generation, Language, Body Mass Index, and Activity Patterns in Hispanic Children

    PubMed Central

    Taverno, Sharon E.; Rollins, Brandi Y.; Francis, Lori A.

    2010-01-01

    Background The acculturation hypothesis proposes an overall disadvantage in health outcomes for Hispanic immigrants with more time spent living in the U.S., but little is known about how generational status and language may influence Hispanic children’s relative weight and activity patterns. Purpose The association between generation and language was investigated with relative weight (BMI z-scores), physical activity, screen time, and participation in extracurricular activities (e.g., sports, clubs) in a U.S.-based, nationally representative sample of Hispanic children. Methods Participants included 2,012 Hispanic children aged 6–11 years from the cross-sectional, 2003 National Survey of Children’s Health. Children were grouped according to generational status (1st, 2nd or 3rd), and the primary language spoken in the home (English vs non-English). Primary analyses included adjusted logistic and multinomial logistic regression to examine the relationships among variables; all analyses were conducted between 2008 and 2009. Results Compared to 3rd generation, English speakers, 1st and 2nd generation, non-English speakers were over two times more likely to be obese. Moreover, 1st generation, non-English speakers were half as likely to engage in regular physical activity and sports. Both 1st and 2nd generation, non-English speakers were less likely to participate in clubs compared to 2nd and 3rd generation, English speakers. Overall, all non–English speaking groups reported less screen time compared to 3rd generation, English speakers. Conclusions The hypothesis that Hispanics lose their health protection with more time spent in the U.S. was not supported in this sample of Hispanic children. PMID:20117570

  10. Use of 3G mobile phone links for teleconsultation between a moving ambulance and a hospital base station.

    PubMed

    Banitsas, Konstantinos A; Perakis, Konstantinos; Tachakra, Sapal; Koutsouris, Dimitrios

    2006-01-01

    We developed a mobile teleconsultation system based on third-generation mobile phone links. The system comprised a laptop computer and a digital camcorder. It was installed inside an ambulance to allow video-conferencing between the moving vehicle and a doctor at a base station. In addition to video and voice, high-quality still images could also be transmitted. A series of 17 trial runs with real ambulance patients was conducted in the city of Athens. In general, the videoconferencing sessions produced relatively clear video. The bandwidth was high enough for a satisfactory video of 10-15 frames/s. During a total testing period of 23 h and in an area of about 180 km2, there were nine instances of signal loss, amounting to a total of 17 min. The general opinion formed by the doctors was that the system produced good results. All initial diagnoses made using the system agreed with the final diagnoses of the patients. The study showed that the mobile system could reduce the time before an ambulance patient is seen by a doctor. PMID:16438775

  11. Does the Brain Detect 3G Mobile Phone Radiation Peaks? An Explorative In-Depth Analysis of an Experimental Study

    PubMed Central

    Roggeveen, Suzanne; van Os, Jim; Lousberg, Richel

    2015-01-01

    This study aimed to investigate whether third generation mobile phone radiation peaks result in event related potentials. Thirty-one healthy females participated. In this single-blind, cross-over design, a 15 minute mobile phone exposure was compared to two 15 minute sham phone conditions, one preceding and one following the exposure condition. Each participant was measured on two separate days, where mobile phone placement was varied between the ear and heart. EEG activity and radiofrequency radiation were recorded jointly. Epochs of 1200ms, starting 200ms before and lasting until 1000ms after the onset of a radiation peak, were extracted from the exposure condition. Control epochs were randomly selected from the two sham phone conditions. The main a-priori hypothesis to be tested concerned an increase of the area in the 240-500ms post-stimulus interval, in the exposure session with ear-placement. Using multilevel regression analyses the placement*exposure interaction effect was significant for the frontal and central cortical regions, indicating that only in the mobile phone exposure with ear-placement an enlarged cortical reactivity was found. Post-hoc analyses based on visual inspection of the ERPs showed a second significantly increased area between 500-1000ms post-stimulus for almost every EEG location measured. It was concluded that, when a dialing mobile phone is placed on the ear, its radiation, although unconsciously, is electrically detected by the brain. The question of whether or not this cortical reactivity results in a negative health outcome has to be answered in future longitudinal experiments. PMID:25962168

  12. Research-Teaching Linkages: Practice and Policy. Proceedings of the Third Annual Conference of the National Academy for the Integration of Research, Teaching and Learning (3rd, Dublin, Ireland, November 11-12, 2009)

    ERIC Educational Resources Information Center

    Murphy, Jennifer, Ed.; Griffin, Carrie, Ed.; Higgs, Bettie, Ed.

    2010-01-01

    The third annual conference of the National Academy for Integration of Research, Teaching and Learning (NAIRTL) was held at Trinity College Dublin on 11-12 November 2009, and was attended by over 300 delegates. The theme--"Research-Teaching Linkages: Practice and Policy"--was timely and generated some fascinating papers, workshops and debates,…

  13. First Demonstration of the Echo-Enabled Harmonic Generation Technique for Short-Wavelength Seeded Free Electron Lasers

    SciTech Connect

    Xiang, D.; Colby, E.; Dunning, M.; Gilevich, S.; Hast, C.; Jobe, K.; McCormick, D.; Nelson, J.; Raubenheimer, T.O.; Soong, K.; Stupakov, G.; Szalata, Z.; Walz, D.; Weathersby, S.; Woodley, M.; Pernet, P.-L.; /Ecole Polytechnique, Lausanne

    2010-08-25

    We report the first experimental demonstration of the echo-enabled harmonic generation (EEHG) technique which holds great promise for generation of high power, fully coherent short-wavelength radiation. In this experiment, coherent radiation at the 3rd and 4th harmonic of the second seed laser is generated from the so-called beam echo effect. The experiment confirms the physics behind this technique and paves the way for applying the EEHG technique for seeded x-ray free electron lasers.

  14. Comparison of Analysis Results Between 2D/1D Synthesis and RAPTOR-M3G in the Korea Standard Nuclear Plant (KSNP)

    NASA Astrophysics Data System (ADS)

    Joung Lim, Mi; Maeng, Young Jae; Fero, Arnold H.; Anderson, Stanwood L.

    2016-02-01

    The 2D/1D synthesis methodology has been used to calculate the fast neutron (E > 1.0 MeV) exposure to the beltline region of the reactor pressure vessel. This method uses the DORT 3.1 discrete ordinates code and the BUGLE-96 cross-section library based on ENDF/B-VI. RAPTOR-M3G (RApid Parallel Transport Of Radiation-Multiple 3D Geometries) which performs full 3D calculations was developed and is based on domain decomposition algorithms, where the spatial and angular domains are allocated and processed on multi-processor computer architecture. As compared to traditional single-processor applications, this approach reduces the computational load as well as the memory requirement per processor. Both methods are applied to surveillance test results for the Korea Standard Nuclear Plant (KSNP)-OPR (Optimized Power Reactor) 1000 MW. The objective of this paper is to compare the results of the KSNP surveillance program between 2D/1D synthesis and RAPTOR-M3G. Each operating KSNP has a reactor vessel surveillance program consisting of six surveillance capsules located between the core and the reactor vessel in the downcomer region near the reactor vessel wall. In addition to the In-Vessel surveillance program, an Ex-Vessel Neutron Dosimetry (EVND) program has been implemented. In order to estimate surveillance test results, cycle-specific forward transport calculations were performed by 2D/1D synthesis and by RAPTOR-M3G. The ratio between measured and calculated (M/C) reaction rates will be discussed. The current plan is to install an EVND system in all of the Korea PWRs including the new reactor type, APR (Advanced Power Reactor) 1400 MW. This work will play an important role in establishing a KSNP-specific database of surveillance test results and will employ RAPTOR-M3G for surveillance dosimetry location as well as positions in the KSNP reactor vessel.

  15. In utero and lactational dioxin exposure induces Sema3b and Sema3g gene expression in the developing mouse brain.

    PubMed

    Kimura, Eiki; Endo, Toshihiro; Yoshioka, Wataru; Ding, Yunjie; Ujita, Waka; Kakeyama, Masaki; Tohyama, Chiharu

    2016-07-22

    In the developing mammalian brain, neural network formation is regulated by complex signaling cascades. In utero and lactational dioxin exposure is known to induce higher brain function abnormalities and dendritic growth disruption in rodents. However, it is unclear whether perinatal dioxin exposure affects the expression of genes involved in neural network formation. Therefore, we investigated changes in gene expression in the brain regions of developing mice born to dams administered 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; dose: 0, 0.6, or 3.0 μg/kg) on gestational day 12.5. Quantitative RT-PCR showed that TCDD exposure induced Ahrr expression in the cerebral cortex, hippocampus, and olfactory bulb of 3-day-old mice. Gene microarray analysis indicated that the mRNA expression levels of Sema3b and Sema3g, which encode proteins that are known to control axonal projections, were elevated in the olfactory bulb of TCDD-exposed mice, and the induction of these genes was observed during a 2-week postnatal period. Increased Sema3g expression was also observed in the brain but not in the kidney, liver, lung, and spleen of TCDD-exposed neonatal mice. These results indicate that the Sema3b and Sema3g genes are sensitive to brain-specific induction by dioxin exposure, which may disrupt neural network formation in the mammalian nervous system, thereby leading to abnormal higher brain function in adulthood. PMID:27178212

  16. D1((2)B2g) to D0((2)Au) Fluorescence from the Matrix-Isolated Perylene Cation Following Laser Excitation into the D5(2)B3g) and D2 ((2)B3g) Electronic States

    NASA Technical Reports Server (NTRS)

    Chillier, Xavier D. F.; Stone, Bradley M.; Joblin, Christine; Salama, Farid; Allamandola, Louis J.; DeVincenzi, Donald L. (Technical Monitor)

    2001-01-01

    Fluorescence spectra of the perylene cation, pumped by direct laser excitation via the D(sub 2)((2)B(sub 3g)) (left arrow) D(sub 0)((2)A(sub u)) and D(sub 5)(2)B(sub 3g)) (left arrow) D(sub 0)((2)A(sub u)) transitions, are presented. Direct excitation into the D5 or D2 states is followed by rapid non-radiative relaxation to D1 that, in turn,relaxes radiatively. Excitation spectroscopy across the D(sub 2)((2)B(sub 3g)) (left arrow) D(sub 0)((2)A(sub u)) transition near 730 nm shows that site splitting plays little or no role in determining the spectral substructure in the ion spectra. Tentative assignments for ground state vibrational frequencies are made by comparison of spectral intervals with calculated normal mode frequencies.

  17. D1(2B2g)→D0(2Au) fluorescence from the matrix-isolated perylene cation following laser excitation into the D5(2B3g) and D2(2B3g) electronic states

    NASA Astrophysics Data System (ADS)

    Chillier, Xavier D. F.; Stone, Bradley M.; Joblin, Christine; Salama, Farid; Allamandola, Louis J.

    2002-04-01

    Fluorescence spectra of the perylene cation, isolated in an argon matrix and pumped by direct laser excitation via the D2(2B3g)←D0(2Au) and D5(2B3g)←D0(2Au) transitions, are presented. Direct excitation into the D5 or D2 states is followed by rapid nonradiative relaxation to D1 that, in turn, relaxes radiatively. Excitation spectroscopy across the D2(2B3g)←D0(2Au) transition near 731 nm shows that site splitting plays little or no role in determining the spectral substructure in the ion spectra. Tentative assignments for ground state vibrational frequencies are made by a comparison of spectral intervals with calculated normal mode frequencies, with the strongest IR bands leading to the most intense vibronic bands.

  18. Strengthening the influenza vaccine virus selection and development process: Report of the 3rd WHO Informal Consultation for Improving Influenza Vaccine Virus Selection held at WHO headquarters, Geneva, Switzerland, 1-3 April 2014.

    PubMed

    Ampofo, William K; Azziz-Baumgartner, Eduardo; Bashir, Uzma; Cox, Nancy J; Fasce, Rodrigo; Giovanni, Maria; Grohmann, Gary; Huang, Sue; Katz, Jackie; Mironenko, Alla; Mokhtari-Azad, Talat; Sasono, Pretty Multihartina; Rahman, Mahmudur; Sawanpanyalert, Pathom; Siqueira, Marilda; Waddell, Anthony L; Waiboci, Lillian; Wood, John; Zhang, Wenqing; Ziegler, Thedi

    2015-08-26

    Despite long-recognized challenges and constraints associated with their updating and manufacture, influenza vaccines remain at the heart of public health preparedness and response efforts against both seasonal and potentially pandemic influenza viruses. Globally coordinated virological and epidemiological surveillance is the foundation of the influenza vaccine virus selection and development process. Although national influenza surveillance and reporting capabilities are being strengthened and expanded, sustaining and building upon recent gains has become a major challenge. Strengthening the vaccine virus selection process additionally requires the continuation of initiatives to improve the timeliness and representativeness of influenza viruses shared by countries for detailed analysis by the WHO Global Influenza Surveillance and Response System (GISRS). Efforts are also continuing at the national, regional, and global levels to better understand the dynamics of influenza transmission in both temperate and tropical regions. Improved understanding of the degree of influenza seasonality in tropical countries of the world should allow for the strengthening of national vaccination policies and use of the most appropriate available vaccines. There remain a number of limitations and difficulties associated with the use of HAI assays for the antigenic characterization and selection of influenza vaccine viruses by WHOCCs. Current approaches to improving the situation include the more-optimal use of HAI and other assays; improved understanding of the data produced by neutralization assays; and increased standardization of serological testing methods. A number of new technologies and associated tools have the potential to revolutionize influenza surveillance and response activities. These include the increasingly routine use of whole genome next-generation sequencing and other high-throughput approaches. Such approaches could not only become key elements in outbreak

  19. Microwave harmonic generation and nonlinearity in microplasmas

    NASA Astrophysics Data System (ADS)

    Gregório, José; Parsons, Stephen; Hopwood, Jeffrey

    2016-06-01

    Nonlinearities in microplasmas excited by microwaves are described both experimentally and through a 2D fluid model. A split-ring resonator generates a microplasma in a 150 μm discharge gap at 1 GHz. Nonlinearity generates both radiated and conducted harmonics which are measured from 0.2–760 Torr (Ar) for power levels between 0.5 and 3 W. Asymmetric electrode configurations produce the highest 3rd harmonic power (>10 mW) at an optimal pressure of the order of 0.3 Torr. The microplasma is also demonstrated as a mixer. The experimental results are explained with the aid of a fluid model of the microplasma. The model shows that the smaller electrode in an asymmetric device is forced to attain a large microwave potential that strongly modulates the sheath thickness and the local electron energy. The voltage-dependent sheath width gives rises to a nonlinear sheath capacitance as well as short pulses of hot electron flux to the electrode. The modeled 3rd harmonic current is converted to an extractable harmonic power by a microwave circuit model. Using this technique the modeled and measured harmonic production of the microplasma are found to compare favorably.

  20. Prevalence of lactose fermenting coliforms resistant to third generation cephalosporins in cattle feedlot throughout a production cycle and molecular characterization of resistant isolates

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Introduction: Increases in incidence of human infections caused by Enterobacteriaceae resistant to 3rd generation cephalosporins (3GC) have become a public health concern. The 3GC ceftiofur is commonly used for the therapeutic treatment of feedlot cattle but the impact this practice has on public h...

  1. Microscopic origin of the 1.3 G{sub 0} conductance observed in oxygen-doped silver quantum point contacts

    SciTech Connect

    Tu, Xingchen; Wang, Minglang; Hou, Shimin; Sanvito, Stefano

    2014-11-21

    Besides the peak at one conductance quantum, G{sub 0}, two additional features at ∼0.4 G{sub 0} and ∼1.3 G{sub 0} have been observed in the conductance histograms of silver quantum point contacts at room temperature in ambient conditions. In order to understand such feature, here we investigate the electronic transport and mechanical properties of clean and oxygen-doped silver atomic contacts by employing the non-equilibrium Green's function formalism combined with density functional theory. Our calculations show that, unlike clean Ag single-atom contacts showing a conductance of 1 G{sub 0}, the low-bias conductance of oxygen-doped Ag atomic contacts depends on the number of oxygen impurities and their binding configuration. When one oxygen atom binds to an Ag monatomic chain sandwiched between two Ag electrodes, the low-bias conductance of the junction always decreases. In contrast, when the number of oxygen impurities is two and the O-O axis is perpendicular to the Ag-Ag axis, the transmission coefficients at the Fermi level are, respectively, calculated to be 1.44 for the junction with Ag(111) electrodes and 1.24 for that with Ag(100) electrodes, both in good agreement with the measured value of ∼1.3 G{sub 0}. The calculated rupture force (1.60 nN for the junction with Ag(111) electrodes) is also consistent with the experimental value (1.66 ± 0.09 nN), confirming that the measured ∼1.3 G{sub 0} conductance should originate from Ag single-atom contacts doped with two oxygen atoms in a perpendicular configuration.

  2. H3.3 G34R mutations in pediatric primitive neuroectodermal tumors of central nervous system (CNS-PNET) and pediatric glioblastomas: possible diagnostic and therapeutic implications?

    PubMed

    Gessi, Marco; Gielen, Gerrit H; Hammes, Jennifer; Dörner, Evelyn; Mühlen, Anja Zur; Waha, Andreas; Pietsch, Torsten

    2013-03-01

    Pediatric glioblastomas recently have been exon sequenced with evidence that approximately 30 % of cases harbour mutations of the histone H3.3 gene. Although studies to determinate their role in risk stratification are on-going, it remains to be determined whether H3.3 mutations could be found in other tumors such as pediatric primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) and whether the presence of H3.3 mutations in glioblastomas could be used as diagnostic tool in their differential diagnosis with CNS-PNETs. We performed a large mutational pyrosequencing-based screening on 123 pediatric glioblastomas and 33 CNS-PNET. The analysis revealed that 39/123 (31.7 %) glioblastomas carry H3.3 mutations. The K27M (AAG → ATG, lysine → methionine) mutation was found in 33 glioblastomas (26 %); the G34R (GGG → AGG, glycine → arginine) was observed in 6 glioblastomas (5.5 %). However, we also identified 4 of 33 cases (11 %) of CNS-PNETs harbouring a H3.3 G34R mutation. Multiplex ligation-dependent probe amplification analysis revealed PDGFR-alpha amplification and EGFR gain in two cases and N-Myc amplification in one case of H3.3 G34R mutated CNS-PNET. None of H3.3 mutated tumors presented a CDKN2A loss. In conclusion, because pediatric patients with glioblastoma and CNS-PNET are treated according to different therapeutic protocols, these findings may raise further concerns about the reliability of the histological diagnosis in the case of an undifferentiated brain tumor harbouring G34R H3.3 mutation. In this view, additional studies are needed to determine whether H3.3 G34 mutated CNS-PNET/glioblastomas may represent a defined tumor subtype. PMID:23354654

  3. Linking Substance Use and Problem Behavior across Three Generations

    ERIC Educational Resources Information Center

    Bailey, Jennifer A.; Hill, Karl G.; Oesterle, Sabrina; Hawkins, J. David

    2006-01-01

    This study examined patterns of between-generation continuity in substance use from generation 1 (G1) parents to generation 2 (G2) adolescents and from G2 adult substance use and G1 substance use to generation 3 (G3) problem behavior in childhood. Structural equation modeling of prospective, longitudinal data from 808 participants, their parents,…

  4. Zinc-mediated binding of a low-molecular-weight stabilizer of the host anti-viral factor apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G.

    PubMed

    Radwan, Mohamed O; Sonoda, Sachiko; Ejima, Tomohiko; Tanaka, Ayumi; Koga, Ryoko; Okamoto, Yoshinari; Fujita, Mikako; Otsuka, Masami

    2016-09-15

    Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G (APOBEC3G, A3G), is a human anti-virus restriction protein which works deaminase-dependently and -independently. A3G is known to be ubiquitinated by HIV-1 viral infectivity factor (Vif) protein, leading to proteasomal degradation. A3G contains two zinc ions at the N-terminal domain and the C-terminal domain. Four lysine residues, K(297), K(301), K(303), and K(334), are known to be required for Vif-mediated A3G ubiquitination and degradation. Previously, we reported compound SN-1, a zinc chelator that increases steady-state expression level of A3G in the presence of Vif. In this study, we prepared Biotin-SN-1, a biotinylated derivative of SN-1, to study the SN-1-A3G interaction. A pull-down assay revealed that Biotin-SN-1 bound A3G. A zinc-abstraction experiment indicated that SN-1 binds to the zinc site of A3G. We carried out a SN-1-A3G docking study using molecular operating environment. The calculations revealed that SN-1 binds to the C-terminal domain through Zn(2+), H(216), P(247), C(288), and Y(315). Notably, SN-1-binding covers the H(257), E(259), C(288), and C(291) residues that participate in zinc-mediated deamination, and the ubiquitination regions of A3G. The binding of SN-1 presumably perturbs the secondary structure between C(288) and Y(315), leading to less efficient ubiquitination. PMID:27475536

  5. BPSK optical mm-wave signal generation by septupling frequency via a single optical phase modulator

    NASA Astrophysics Data System (ADS)

    Wu, Peng; Ma, Jianxin

    2016-09-01

    In this paper, we have proposed a novel and simple scheme to generate the BPSK optical millimeter wave (MMW) signal with frequency septupling by using an optical phase modulator (PM) and a wavelength selective switch (WSS). In this scheme, the PM is driven by a radio frequency (RF) BPSK signal at the optimized modulation index of 4.89 to assure the 4th and 3rd-order sidebands have equal amplitudes. An wavelength selective switch (WSS) is used to abstract the -4th and +3rd-order sidebands from the spectrum generated by RF BPSK signal modulating the lightwave to form the BPSK optical MMW signal with frequency septupling the driving RF signal. In these two tones, only the +3rd-order sideband bears the BPSK signal while the -4th-order sideband is unmodulated since the phase information is canceled by the even times multiplication of the phase of BPSK signal. The MMW signal can avoid the pulse walk-off effect and the amplitude fading effect caused by the fiber chromatic dispersion. By adjusting the modulation index to assure the two tones have equal amplitude, the generated optical MMW signal has the maximal opto-electrical conversion efficiency and good transmission performance.

  6. Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1

    SciTech Connect

    Xie, Yong; Muller, W.A.

    1996-10-15

    Human platelet/endothelial cell adhesion molecule-1 (PECAM1), an important member of the immunoglobulin gene superfamily, is widely distributed on cells of the vascular system and mediates cellular interactions through both homophilic and heterophilic adhesive mechanisms. The function of PECAM1 in vitro has begun to be understood, but its function in vivo is yet to be established. To study the function of PECAM1 in vivo, its mouse counterpart was identified and its cDNA gene isolated and characterized. In this study, the mouse chromosomal localization was determined for the mouse gene encoding Pecam. Fluorescence in situ hybridization was used to map the Pecam gene on mouse chromosome 6, region F3-G1. 12 refs., 2 figs.

  7. Analysis of dosimetry from the H.B. Robinson unit 2 pressure vessel benchmark using RAPTOR-M3G and ALPAN

    SciTech Connect

    Fischer, G.A.

    2011-07-01

    Document available in abstract form only, full text of document follows: The dosimetry from the H. B. Robinson Unit 2 Pressure Vessel Benchmark is analyzed with a suite of Westinghouse-developed codes and data libraries. The radiation transport from the reactor core to the surveillance capsule and ex-vessel locations is performed by RAPTOR-M3G, a parallel deterministic radiation transport code that calculates high-resolution neutron flux information in three dimensions. The cross-section library used in this analysis is the ALPAN library, an Evaluated Nuclear Data File (ENDF)/B-VII.0-based library designed for reactor dosimetry and fluence analysis applications. Dosimetry is evaluated with the industry-standard SNLRML reactor dosimetry cross-section data library. (authors)

  8. New functions developed for ICU/CCU remote monitoring system using a 3G mobile phone and evaluations of the system.

    PubMed

    Zhang, Pu; Kumabe, Akinoubu; Kogure, Yuichi; Akutagawa, Masatake; Kinouchi, Yohsuke; Zhang, Qinyu

    2008-01-01

    As a combination of medical information and Telecommunication technologies, telemedicine plays a more and more important role in supporting doctors to diagnose and taking care of people's daily health. It is also an appropriate means to solve the conflict between aging of population and inadequacy of doctors, which are the actual condition and inevitable developing trend of the society not only in developed countries. In this paper, some new functions are developed for a ICU/CCU Remote Monitoring System using a 3G mobile phone. Furthermore, some evaluations of the system have been implied on several different mobile phones. The system is anticipated to be adopted by hospitals for its accuracy and real-time performance to supporting telediagnosis for patients in ICU/CCU. PMID:19163924

  9. Synthesis, cytotoxicity and antiviral evaluation of new series of imidazo[4,5-g]quinoline and pyrido[2,3-g]quinoxalinone derivatives.

    PubMed

    Briguglio, Irene; Loddo, Roberta; Laurini, Erik; Fermeglia, Maurizio; Piras, Sandra; Corona, Paola; Giunchedi, Paolo; Gavini, Elisabetta; Sanna, Giuseppina; Giliberti, Gabriele; Ibba, Cristina; Farci, Pamela; La Colla, Paolo; Pricl, Sabrina; Carta, Antonio

    2015-11-13

    Linear aromatic N-tricyclic compounds with promising antiviral activity and minimal cytotoxicity were prepared and analyzed in the last years. Specifically, the pyrido[2,3-g]quinoxalinone nucleus was found endowed with high potency against several pathogenic RNA viruses as etiological agents of important veterinary and human pathologies. Following our research program on new antiviral agents we have designed, synthesized and assayed new series of imidazo[4,5-g]quinoline and pyrido[2,3-g]quinoxalinone derivatives. Lead compounds 1-4 were further modified to enhance their antiviral activity and reduce their cytotoxicity. Thus, different substituents were introduced on N atom at position 1 or the O atom at position 2 of the leads; contextually, several groups were inserted on the nitrogen atom at position 7 of diaminoquinoline intermediates. Title compounds were tested in cell-based assays for cytotoxicity and antiviral activity against RNA virus families containing single-stranded (either positive-sense (ssRNA+) or negative-sense (ssRNA-)), and double-stranded genomes (dsRNA), and against two representatives of DNA virus families. Some derivatives emerged as potential leads for further development as antiviral agents against some viruses of public health significance, such as RSV, Reo, BVDV and HCV. Particularly, compounds 4, 11b, 11c, 13c, 15a, 18 and 21 resulted active against BVDV at concentrations ranging from 1.3 to 5 μM. Compound 21 was also evaluated for its activity on the BVDV RdRp. Compound 4 was also tested as potential anti-HCV compound in a subgenomic replication assay. Molecular simulation results provided a molecular rationale for the anti-BVDV activity of these compounds. PMID:26479028

  10. The 3D-HST Survey: Hubble Space Telescope WFC3/G141 Grism Spectra, Redshifts, and Emission Line Measurements for ~ 100,000 Galaxies

    NASA Astrophysics Data System (ADS)

    Momcheva, Ivelina G.; Brammer, Gabriel B.; van Dokkum, Pieter G.; Skelton, Rosalind E.; Whitaker, Katherine E.; Nelson, Erica J.; Fumagalli, Mattia; Maseda, Michael V.; Leja, Joel; Franx, Marijn; Rix, Hans-Walter; Bezanson, Rachel; Da Cunha, Elisabete; Dickey, Claire; Förster Schreiber, Natascha M.; Illingworth, Garth; Kriek, Mariska; Labbé, Ivo; Ulf Lange, Johannes; Lundgren, Britt F.; Magee, Daniel; Marchesini, Danilo; Oesch, Pascal; Pacifici, Camilla; Patel, Shannon G.; Price, Sedona; Tal, Tomer; Wake, David A.; van der Wel, Arjen; Wuyts, Stijn

    2016-08-01

    We present reduced data and data products from the 3D-HST survey, a 248-orbit HST Treasury program. The survey obtained WFC3 G141 grism spectroscopy in four of the five CANDELS fields: AEGIS, COSMOS, GOODS-S, and UDS, along with WFC3 H 140 imaging, parallel ACS G800L spectroscopy, and parallel I 814 imaging. In a previous paper, we presented photometric catalogs in these four fields and in GOODS-N, the fifth CANDELS field. Here we describe and present the WFC3 G141 spectroscopic data, again augmented with data from GO-1600 in GOODS-N (PI: B. Weiner). We developed software to automatically and optimally extract interlaced two-dimensional (2D) and one-dimensional (1D) spectra for all objects in the Skelton et al. (2014) photometric catalogs. The 2D spectra and the multi-band photometry were fit simultaneously to determine redshifts and emission line strengths, taking the morphology of the galaxies explicitly into account. The resulting catalog has redshifts and line strengths (where available) for 22,548 unique objects down to {{JH}}{IR}≤slant 24 (79,609 unique objects down to {{JH}}{IR}≤slant 26). Of these, 5459 galaxies are at z\\gt 1.5 and 9621 are at 0.7\\lt z\\lt 1.5, where Hα falls in the G141 wavelength coverage. The typical redshift error for {{JH}}{IR}≤slant 24 galaxies is {σ }z≈ 0.003× (1+z), i.e., one native WFC3 pixel. The 3σ limit for emission line fluxes of point sources is 2.1× {10}-17 erg s‑1 cm‑2. All 2D and 1D spectra, as well as redshifts, line fluxes, and other derived parameters, are publicly available.18

  11. Evaluating and Quantifying the Climate-Driven Interannual Variability in Global Inventory Modeling and Mapping Studies (GIMMS) Normalized Difference Vegetation Index (NDVI3g) at Global Scales

    NASA Technical Reports Server (NTRS)

    Zeng, Fanwei; Collatz, George James; Pinzon, Jorge E.; Ivanoff, Alvaro

    2013-01-01

    Satellite observations of surface reflected solar radiation contain informationabout variability in the absorption of solar radiation by vegetation. Understanding thecauses of variability is important for models that use these data to drive land surface fluxesor for benchmarking prognostic vegetation models. Here we evaluated the interannualvariability in the new 30.5-year long global satellite-derived surface reflectance index data,Global Inventory Modeling and Mapping Studies normalized difference vegetation index(GIMMS NDVI3g). Pearsons correlation and multiple linear stepwise regression analyseswere applied to quantify the NDVI interannual variability driven by climate anomalies, andto evaluate the effects of potential interference (snow, aerosols and clouds) on the NDVIsignal. We found ecologically plausible strong controls on NDVI variability by antecedent precipitation and current monthly temperature with distinct spatial patterns. Precipitation correlations were strongest for temperate to tropical water limited herbaceous systemswhere in some regions and seasons 40 of the NDVI variance could be explained byprecipitation anomalies. Temperature correlations were strongest in northern mid- to-high-latitudes in the spring and early summer where up to 70 of the NDVI variance was explained by temperature anomalies. We find that, in western and central North America,winter-spring precipitation determines early summer growth while more recent precipitation controls NDVI variability in late summer. In contrast, current or prior wetseason precipitation anomalies were correlated with all months of NDVI in sub-tropical herbaceous vegetation. Snow, aerosols and clouds as well as unexplained phenomena still account for part of the NDVI variance despite corrections. Nevertheless, this study demonstrates that GIMMS NDVI3g represents real responses of vegetation to climate variability that are useful for global models.

  12. Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activity.

    PubMed

    Bolognese, Adele; Correale, Gaetano; Manfra, Michele; Esposito, Anna; Novellino, Ettore; Lavecchia, Antonio

    2008-12-25

    Two series of quinolinquinone derivatives, 2'H-spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-2,4',5,9'-tetraones (2a-n) and 2H-spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-3',4,6',9-tetraones (3a-e), were designed and synthesized using the previously described ethyl 3-amino-4,9-dioxo-2,3,4,9-tetrahydrothieno[2,3-g]quinoline-3-carboxylate (1) as a starting material. All compounds were evaluated for their antiproliferative activity against a panel of representative liquid and solid human tumor cell lines and exhibit IC(50) values in the micromolar/submicromolar range. Series 2 displayed higher cytotoxicity than did series 3. The nature of the substituents on both imidazoline and triazinane N1 nitrogen markedly affected the activity profile of these series. Spectrophotometric and fluorescence measurements as well as unwinding assays performed on the most cytotoxic compounds, 2c, 2g, and 2k, showed that they are nonintercalative DNA agents and inhibit the catalytic activity of Topo II in a concentration-dependent mode. 2g was the most active Topo II inhibitor with activity levels comparable to those of VP-16. PMID:19053767

  13. The 1991 3rd NASA Symposium on VLSI Design

    NASA Technical Reports Server (NTRS)

    Maki, Gary K.

    1991-01-01

    Papers from the symposium are presented from the following sessions: (1) featured presentations 1; (2) very large scale integration (VLSI) circuit design; (3) VLSI architecture 1; (4) featured presentations 2; (5) neural networks; (6) VLSI architectures 2; (7) featured presentations 3; (8) verification 1; (9) analog design; (10) verification 2; (11) design innovations 1; (12) asynchronous design; and (13) design innovations 2.

  14. The radiology of joint disease. 3rd Ed

    SciTech Connect

    Forrester, D.M.; Brown, J.C.

    1987-01-01

    The book is a systematic radiographic approach to the arthritides. Part one deals with hand abnormalities ''to facilitate the teaching of basic principles and to dramatize the differences between radiographic features of various arthritides,'' as stated in the forward of the first edition. Part two, ''Arthritis from Head to Foot,'' illustrates the same diseases as they affect other joints. The ABCs (alignment, bone mineralization, cartilage space, soft tissue) approach is followed throughout the book. For example, reflex sympathetic dystrophy syndrome is dealt with in six different locations, and metatarsal stress fractures are mentioned in a chapter on erosions in rheumatoid arthritis.

  15. Mathematics in Early Years Education. 3rd Edition

    ERIC Educational Resources Information Center

    Montague-Smith, Ann; Price, Alison

    2012-01-01

    This third edition of the best-selling "Mathematics in Nursery Education" provides an accessible introduction to the teaching of mathematics in the early years. Covering all areas of mathematics learning--number and counting, calculation, pattern, shape, measures and data handling--it summarises the research findings and underlying key concepts…

  16. The Philosophic Process in Physical Education. 3rd Edition.

    ERIC Educational Resources Information Center

    Harper, William A.; And Others

    This book on the process of philosophic thought as it relates to physical education is divided into four parts. The first part, "Philosophy as Action," aims to help the student to develop and refine his ability to philosophize, to direct reasoned beliefs toward a goal, to see that reasoned beliefs derive from thinking, to avoid error and dangers…

  17. Intelec 81, International Telecommunications Energy Conference, 3rd, 1981

    SciTech Connect

    Anon

    1981-01-01

    This conference proceedings contains 60 papers. Thirteen papers are indexed separately. Topics covered include: microprocessors for telecommunications power; distribution and economics; energy conservation and building environment; batteries; inverters; solar and wind power systems; uninterruptable power supplies; DC:DC converters; AC standby systems; reliability; and, DC power plant and rectifiers.

  18. Explanatory Supplement to the Astronomical Almanac (3rd Edition)

    NASA Astrophysics Data System (ADS)

    Urban, Sean E.; Seidelmann, P. K.

    2014-01-01

    Publications and software from the the Astronomical Applications Department of the US Naval Observatory (USNO) are used throughout the world, not only in the Department of Defense for safe navigation, but by many people including other navigators, astronomers, aerospace engineers, and geodesists. Products such as The Nautical Almanac, The Astronomical Almanac, and the Multiyear Interactive Computer Almanac (MICA) are regarded as international standards. To maintain credibility, it is imperative that the methodologies employed and the data used are well documented. "The Explanatory Supplement to the Astronomical Almanac" (hereafter, "The ES") is a major source of such documentation. It is a comprehensive reference book on positional astronomy, covering the theories and algorithms used to produce The Astronomical Almanac, an annual publication produced jointly by the Nautical Almanac Office of USNO and Her Majesty's Nautical Almanac Office (HMNAO). The first edition of The ES appeared in 1961, and the second followed in 1992. Several major changes have taken place in fundamental astronomy since the second edition was published. Advances in radio observations allowed the celestial reference frame to be tied to extragalactic radio sources, thus the International Celestial Reference System replaced the FK5 system. The success of ESA's Hipparcos satellite dramatically altered observational astrometry. Improvements in Earth orientation observations lead to new precession and nutation theories. Additionally, a new positional paradigm, no longer tied to the ecliptic and equinox, was accepted. Largely because of these changes, staff at USNO and HMNAO decided the time was right for the next edition of The ES. The third edition is now available; it is a complete revision of the 1992 book. Along with subjects covered in the previous two editions, the book also contains descriptions of the major advancements in positional astronomy over the last 20 years, some of which are described above. Extensive references to online information are given. This paper will discuss this latest edition of the Explanatory Supplement.

  19. Donations Increase for 3rd Year in a Row

    ERIC Educational Resources Information Center

    Strout, Erin

    2007-01-01

    This article talks about a report on fund-raising campaign done by universities and colleges to support their educational programs. According to the "Voluntary Support of Education" annual report released by the Council for Aid to Education, alumni and other individual donors gave just more than half of the total amount raised. The country's…

  20. [3rd Hungarian Breast Cancer Consensus Conference - Surgery Guidelines].

    PubMed

    Lázár, György; Bursics, Attila; Farsang, Zoltán; Harsányi, László; Kósa, Csaba; Maráz, Róbert; Mátrai, Zoltán; Paszt, Attila; Pavlovics, Gábor; Tamás, Róbert

    2016-09-01

    Therapy for breast cancer today is characterised by ever more precise diagnostic methods and ever more effective oncological treatments, a trend which will certainly continue in the future. Breast preservation and the application of oncoplastic principles are increasingly popular. A sentinel lymph node biopsy in the surgical treatment of the axilla is primary, with the indication for axillary block dissection (ABD) narrowing and radiation therapy becoming an alternative to ABD in certain cases. This publication summarises our recommendations on the surgical treatment of breast cancer based on the content of the 2nd Breast Cancer Consensus Conference and considering the latest international studies and professional recommendations. PMID:27579720

  1. Iowa Family Day Care Handbook. 3rd Edition.

    ERIC Educational Resources Information Center

    Holt, Bess Gene; Karas, Shirley C.

    The purposes of this handbook are (1) to help individuals who are thinking about becoming family day care providers decide whether the profession is appropriate for themselves and their families, and (2) to present ideas for setting up and maintaining a family day care home that provides high quality service to families, a developmental learning…

  2. Textbook of Child and Adolescent Psychiatry. 3rd Edition.

    ERIC Educational Resources Information Center

    Wiener, Jerry M.; Dulcan, Mina K.

    The third edition of this textbook continues its tradition of integrating clinical wisdom and scientific research to improve patient care and advocacy for children and families. Each of the 56 chapters presents a summary of a core topic, blending clinical experience with evidence-based practices in assessment and treatment. Divided into 10 parts,…

  3. The Development of TAFE in Australia. 3rd Edition.

    ERIC Educational Resources Information Center

    Goozee, Gillian

    This document traces the development of Australia's technical and further education (TAFE) system, which offers a wide range of courses providing education and training for employment at the operative, trade, and paraprofessional levels, as well as general education and literacy programs. The following are among the topics discussed: (1) general…

  4. EMSL Quarterly Highlights Report: FY 2008, 3rd Quarter

    SciTech Connect

    Showalter, Mary Ann

    2008-09-16

    The EMSL Quarterly Highlights Report covers the science, staff and user recognition, and publication activities that occurred during the 1st quarter (October 2007 - December 2007) of Fiscal Year 2008.

  5. Business planning for scientists and engineers [3rd edition

    SciTech Connect

    Servo, Jenny C.

    1999-09-01

    This combination text/workbook is intended for use by scientists or engineers actively engaged in developing a product or technology to commercial production. The 'how' of planning is a central theme with special emphasis on development of operational plans and strategic thinking.

  6. Rentz's Student Affairs Practice in Higher Education. 3rd Edition

    ERIC Educational Resources Information Center

    MacKinnon, Fiona J. D.

    2004-01-01

    Students in the field, as well as experienced practitioners and administrators, will herein find an up-to-date and in-depth study of the major student affairs functions of a comprehensive campus program. Within its covers, the graduate student will find chapters describing everything the person new to student affairs needs to know about the major…

  7. Performance Plan: Progress Report, 3rd Quarter Fiscal Year 2000.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC. Student Financial Assistance.

    The U.S. Department of Education Student Financial Assistance (SFA) outlines its three major objectives for fiscal year 2000 in its progress report. The objectives are: 1)customer satisfaction; 2) reduction in the overall cost of delivering student aid; and 3) employee satisfaction. Several new capabilities were added to the Direct Loan servicing…

  8. Proceedings of the 3rd Annual SCOLE Workshop

    NASA Technical Reports Server (NTRS)

    Taylor, Lawrence W., Jr. (Compiler)

    1987-01-01

    Topics addressed include: modeling and controlling the Spacecraft Control Laboratory Experiment (SCOLE) configurations; slewing maneuvers; mathematical models; vibration damping; gravitational effects; structural dynamics; finite element method; distributed parameter system; on-line pulse control; stability augmentation; and stochastic processes.

  9. Growth and mineral nutrition of field crops 3rd Edition

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Green revolution technology of last century led to increased production. The green revolution, however, did not link farming system sustainability to food system sustainability as a whole. In recent years the rate of food-grain production has been lower than the rate of population growth. This will ...

  10. 3rd Miami international conference on alternative energy sources

    SciTech Connect

    Nejat Veziroglu, T.

    1980-01-01

    The conference includes sessions on solar energy, ocean thermal energy, wind energy, hydro power, nuclear breeders and nuclear fusion, synthetic fuels from coal or wastes, hydrogen production and uses, formulation of workable policies on energy use and energy conservation, heat and energy storage, and energy education. The volume of the proceedings presents the papers and lectures in condensed format grouped by subject under forty-two sessions for 319 presentations.

  11. Ectopic 3rd Molar Tooth in the Maxillary Antrum

    PubMed Central

    Bello, Seidu A.; Oketade, Ifeoluwa O.; Osunde, Otasowie D.

    2014-01-01

    Location of ectopic tooth in a nondentate area like the maxillary antrum is rare. A 17-year-old boy, with one year history of recurrent right facial swelling and radiographic finding of a maxillary third molar tooth located at the posterior wall of the maxillary antrum, is presented. Under endotracheal intubation, the tooth was extracted through a Caldwell-Luc antrostomy approach and patient had an uneventful recovery and has been symptom free for eight months. Ectopic tooth in the maxillary antrum is rare and is commonest with maxillary third molar. It may be symptomless but is more commonly associated with inflammatory symptoms. The treatment of choice is surgical excision which is mostly carried out with Caldwell-Luc approach, even though endoscopic approach is being reported. PMID:25132999

  12. Thermal radiation heat transfer (3rd revised and enlarged edition)

    NASA Astrophysics Data System (ADS)

    Siegel, Robert; Howell, John R.

    This book first reviews the overall aspects and background information related to thermal radiation heat transfer and incorporates new general information, advances in analytical and computational techniques, and new reference material. Coverage focuses on radiation from opaque surfaces, radiation interchange between various types of surfaces enclosing a vacuum or transparent medium, and radiation including the effects of partially transmitting media, such as combustion gases, soot, or windows. Boundary conditions and multiple layers are discussed with information on radiation in materials with nonunity refractive indices.

  13. [3rd Hungarian Breast Cancer Consensus Conference - Radiotherapy Guidelines].

    PubMed

    Polgár, Csaba; Kahán, Zsuzsanna; Csejtei, András; Gábor, Gabriella; Landherr, László; Mangel, László; Mayer, Árpád; Fodor, János

    2016-09-01

    The radiotherapy expert panel revised and updated the radiotherapy (RT) guidelines accepted in 2009 at the 2nd Hungarian Breast Cancer Consensus Conference based on new scientific evidence. Radiotherapy of the conserved breast is indicated in ductal carcinoma in situ (St. 0), as RT decreases the risk of local recurrence by 60%. In early stage (St. I-II) invasive breast cancer RT remains a standard treatment following breast conserving surgery. However, in elderly (≥70 years) patients with stage I, hormone receptor positive tumour hormonal therapy without RT can be considered. Hypofractionated (15×2.67 Gy) whole breast irradiation and for selected cases accelerated partial breast irradiation are validated treatment alternatives of conventional (25×2 Gy) whole breast irradiation. Following mastectomy RT significantly decreases the risk of locoregional recurrence and improves overall survival of patients having 1 to 3 (pN1a) or ≥4 (pN2a, pN3a) positive axillary lymph nodes. In selected cases of patients with 1 to 2 positive sentinel lymph nodes axillary dissection can be omitted and substituted with axillary RT. After neoadjuvant chemotherapy (NAC) followed by breast conserving surgery whole breast irradiation is mandatory, while after NAC followed by mastectomy locoregional RT should be given in cases of initial stage III-IV and ypN1 axillary status. PMID:27579722

  14. PREFACE: 3rd International Workshop on Infrared Plasma Spectroscopy

    NASA Astrophysics Data System (ADS)

    Davies, P. B.; Röpcke, Jürgen; Hempel, Frank

    2009-07-01

    This volume containsd a selection of papers from the third Infrared Plasma Spectroscopy (IPS) Workshop held in Greifswald, Germany in July 2008. Although not all the contributions have been written up in time for the deadline for this volume, nevertheless the 12 contributions presented here give a fair representation of the conference topics. The conference comprised four different types of contribution. Firstly, four invited lectures focussed on the prime areas of interest. Secondly, eight shorter contributed talks, grouped as closely as possible with the appropriate invited lecture. These contributed talks covered topics in both pure and applied infrared plasma spectroscopy. A feature of the two previous IPS conferences has been a contribution from commercial organisations namely those involved in manufacturing devices, detectors and spectrometers. This group of participants formed the third part of the conference programme and gave five oral presentations covering topics like QCL and detector/detection developments and novel spectrometer designs. The fourth contributing group comprised 27 poster presentations. It should be mentioned that some of the latter were poster versions of contributed talks. The conference was remarkable for the wide spread of topics covered in a relatively small meeting, consisting of 44 participants. The participants were made up of 34 scientists from within Europe and 4 from the rest of the world. It is interesting to reflect on changes that have occurred since the previous meeting just a year earlier. Two clear developments which have occurred are the emergence of Quantum Cascade Lasers (QCL) and their use in Cavity Ring Down (CRD) spectroscopy. A major shift from cw lead salt diode lasers to cw and pulsed QCL in both pure and applied projects now seems to be well under way. The topics covered in the earlier conferences focussed more on applying infrared spectroscopy to plasma monitoring and control. When choosing the topics to cover the scientific committee felt that this time it would be useful to emphasise new spectroscopic developments as well as covering applications. This might serve as a guide as to where the subject of infrared spectroscopy in combination with plasma sources might be heading in the future i.e. to emphasize pure infrared spectroscopy developments. The first invited lecture (G Guelachvili and N Picque) and the last invited lecture (F K Tittel, Y Bakhirkin, R Curl, A Kosterev, R Lewicki, D Thomasz and S So) were chosen to set the scene and realise this objective. The second (R Engeln, R Zijlmans, S Welzel, O Gabriel, J-P van Helden, J Röpcke and D Schram) and third (X Aubert, C Lazzaroni, D Marinov, O Guaitella, S Welzel, A Pipa, J Röpcke and A Rousseau) invited talks focussed on the application of the IR laser techniques with particular emphasis on the role of surfaces in plasmas and the relevance of plasma surface interactions. Surface plasma interactions did not feature strongly in the two earlier meetings and so this topic too, along with the emphasis on novel infrared spectroscopy techniques, represents a new direction for the conference. Paul B Davies and Jürgen Röpcke International Scientific Committee P B Davies, Cambridge, UK: Chair J Röpcke, Greifswald, Germany: Co-Chair R Engeln, Eindhoven, Netherlands G Hancock, Oxford, U K M Hori, Nagoya, Japan H Linnartz, Leiden, Netherlands R Martini, New York, USA J Meichsner, Greifswald, Germany A Rousseau, Paris, France Local Organizing Committee J Röpcke (INP: Chair) F Hempel (INP: Secretary) J Meichsner (IfP, University of Greifswald) N Lang (INP) L Glawe (INP) C Krcka (INP) B Lindemann (INP) Conference photograph

  15. Parent Involvement in 3rd Grade Special Education

    ERIC Educational Resources Information Center

    Batt, Christine

    2011-01-01

    The focus of this study was to investigate how parent involvement impacts student motivation in third grade special education. The study was conducted at Allen Elementary in Genoa, Ohio during the spring of 2011. After reviewing recent literature, it acknowledges the importance of parent participation on student academic education, the effects of…

  16. Mechanical engineers' handbook, energy and power. 3rd ed.

    SciTech Connect

    Myer Kutz

    2005-12-15

    In addition to chapters on thermophysical properties of fluids, fundamentals of fluid mechanics, thermodynamics, heat transfer, combustion, and furnaces, Book 4 of the Handbook features coverage of both conventional (gaseous and liquid fuels, coal, and nuclear) and alternative (solar, geothermal, and fuel cells) energy sources, plus chapters on power machinery, refrigeration and cryogenics, environmental issues, and thermal systems optimization. Much of the material in this book is new or extensively revised, including coverage of such topics as: Heat pipes; Wind turbines; Fuel cells; Thermal systems optimization; Combustion; Fans, blowers, compressors, and pumps; Indoor environmental control; and Fluid power. Chapters of particular interest are: Combustion by Eric Eddings; Furnaces by Carroll Cone; Gaseous fuels by Richard J. Reed; Coals, lignite, peat by James Keppeler; and Air pollution-control technologies by C.A. Miller.

  17. 3rd International Conference on Turbulent Mixing and Beyond

    NASA Astrophysics Data System (ADS)

    Abarzhi, Snezhana I.; Gauthier, Serge; Keane, Christopher J.; Niemela, Joseph J.

    2013-07-01

    1. Introduction 'Turbulent Mixing and Beyond' (TMB) is the programme established for scientists, by scientists. It is merit-based, and is shaped by requirements of academic credentials, and novelty and quality of information. The goals of this programme are to expose the generic problem of non-equilibrium turbulent processes to a wide scientific community, to promote the development of new ideas in tackling the fundamental aspects of the problem, to assist in application of novel approaches in a broad range of phenomena, in which the turbulent processes occur, and to have a potential impact on technology. The programme was founded in 2007 with the support of the international scientific community and of the US National Science Foundation, the US Air Force Office of the Scientific Research and its European Office for Research and Development in the UK, the UNESCO-IAEA International Centre for Theoretical Physics in Italy, the Commissariat l'Energie Atomique in France, the US Department of Energy and the Department of Energy National Laboratories, the Institute for Laser Engineering in Japan, and the University of Chicago in the USA. The International Conference on Turbulent Mixing and Beyond provides opportunities to bring together researchers from the areas, which include but are not limited to, fluid dynamics, plasmas, high energy density physics, astrophysics, material science, combustion, atmospheric and earth sciences, nonlinear and statistical physics, applied mathematics, probability and statistics, data processing and computations, optics and communications, and to have their attention focused on the long-standing formidable task of non-equilibrium turbulent processes. 2. Non-equilibrium turbulent processes Non-equilibrium turbulent processes play a key role in a wide variety of phenomena, ranging from astrophysical to atomistic scales, under either high or low energy density conditions. Inertial confinement and magnetic fusion, light-matter interaction and non-equilibrium heat transfer, strong shocks and explosions, material transformation under high strain rate, supernovae and accretion discs, stellar non-Boussinesq and magneto-convection, planetary interiors and mantle-lithosphere tectonics, premixed and non-premixed combustion, non-canonical wall-bounded flows, hypersonic and supersonic boundary layers, dynamics of atmosphere and oceanography, are just a few examples to list. A grip on non-equilibrium turbulent processes is crucial for cutting-edge technology such as laser micro-machining, nano-electronics, free-space optical telecommunications and for industrial applications in the areas of aeronautics and aerodynamics. Non-equilibrium turbulent processes are anisotropic, non-local, multi-scale and multi-phase, and often are driven by shocks or acceleration. Their scaling, spectral and invariant properties differ substantially from those of classical Kolmogorov turbulence. At atomistic and meso-scales, the non-equilibrium dynamics depart dramatically from a standard scenario given by Gibbs statistic ensemble average and quasi-static Boltzmann equation. The singular aspect and the similarity of the non-equilibrium dynamics at macroscopic scales are interplayed with the fundamental properties of the Euler and compressible Navier-Stokes equations and with the problem sensitivity to the boundary conditions at discontinuities. The state-of-the-art numerical simulations of multi-phase flows suggest new methods for predictive modelling of the multi-scale non-equilibrium dynamics in fluids and plasmas, for error estimates and uncertainty quantifications, as well as for novel data assimilation techniques. 3. International Conference 'Turbulent Mixing and Beyond' The First and Second International Conferences on Turbulent Mixing and Beyond found that: (i) TMB-related problems have in common a set of outstanding research issues; (ii) their solution has a potential to significantly advance a variety of disciplines in science, technology and mathematics; (iii) TMB participants conduct highly innovative research and their

  18. Ectopic 3rd molar tooth in the maxillary antrum.

    PubMed

    Bello, Seidu A; Oketade, Ifeoluwa O; Osunde, Otasowie D

    2014-01-01

    Location of ectopic tooth in a nondentate area like the maxillary antrum is rare. A 17-year-old boy, with one year history of recurrent right facial swelling and radiographic finding of a maxillary third molar tooth located at the posterior wall of the maxillary antrum, is presented. Under endotracheal intubation, the tooth was extracted through a Caldwell-Luc antrostomy approach and patient had an uneventful recovery and has been symptom free for eight months. Ectopic tooth in the maxillary antrum is rare and is commonest with maxillary third molar. It may be symptomless but is more commonly associated with inflammatory symptoms. The treatment of choice is surgical excision which is mostly carried out with Caldwell-Luc approach, even though endoscopic approach is being reported. PMID:25132999

  19. Smith Newton Vehicle Performance Evaluation - 3rd Quarter 2012 (Brochure)

    SciTech Connect

    Not Available

    2013-03-01

    The Fleet Test and Evaluation Team at the U.S. Department of Energy's National Renewable Energy Laboratory is evaluating and documenting the performance of electric and plug-in hybrid electric drive systems in medium-duty trucks across the nation. Through this project, Smith Electric Vehicles will build and deploy 500 all-electric medium-duty trucks. The trucks will be deployed in diverse climates across the country.

  20. Legal Concepts in Sport: A Primer. 3rd Edition

    ERIC Educational Resources Information Center

    Carpenter, Linda Jean

    2008-01-01

    When most people think of legal issues in sport, they think about negligence. However, most professionals will face a much broader range of issues. For instance, topics such as sexual harassment, corporal punishment, drug testing, transportation, and hazing are all of special importance today. Also anti-discrimination laws and the concepts…

  1. Experimental Chaos - Proceedings of the 3rd Conference

    NASA Astrophysics Data System (ADS)

    Harrison, Robert G.; Lu, Weiping; Ditto, William; Pecora, Lou; Spano, Mark; Vohra, Sandeep

    1996-10-01

    The Table of Contents for the full book PDF is as follows: * Preface * Spatiotemporal Chaos and Patterns * Scale Segregation via Formation of Domains in a Nonlinear Optical System * Laser Dynamics as Hydrodynamics * Spatiotemporal Dynamics of Human Epileptic Seizures * Experimental Transition to Chaos in a Quasi 1D Chain of Oscillators * Measuring Coupling in Spatiotemporal Dynamical Systems * Chaos in Vortex Breakdown * Dynamical Analysis * Radial Basis Function Modelling and Prediction of Time Series * Nonlinear Phenomena in Polyrhythmic Hand Movements * Using Models to Diagnose, Test and Control Chaotic Systems * New Real-Time Analysis of Time Series Data with Physical Wavelets * Control and Synchronization * Measuring and Controlling Chaotic Dynamics in a Slugging Fluidized Bed * Control of Chaos in a Laser with Feedback * Synchronization and Chaotic Diode Resonators * Control of Chaos by Continuous-time Feedback with Delay * A Framework for Communication using Chaos Sychronization * Control of Chaos in Switching Circuits * Astrophysics, Meteorology and Oceanography * Solar-Wind-Magnetospheric Dynamics via Satellite Data * Nonlinear Dynamics of the Solar Atmosphere * Fractal Dimension of Scalar and Vector Variables from Turbulence Measurements in the Atmospheric Surface Layer * Mechanics * Escape and Overturning: Subtle Transient Behavior in Nonlinear Mechanical Models * Organising Centres in the Dynamics of Parametrically Excited Double Pendulums * Intermittent Behaviour in a Heating System Driven by Phase Transitions * Hydrodynamics * Size Segregation in Couette Flow of Granular Material * Routes to Chaos in Rotational Taylor-Couette Flow * Experimental Study of the Laminar-Turbulent Transition in an Open Flow System * Chemistry * Order and Chaos in Excitable Media under External Forcing * A Chemical Wave Propagation with Accelerating Speed Accompanied by Hydrodynamic Flow * Optics * Instabilities in Semiconductor Lasers with Optical Injection * Spatio-Temporal Dynamics of a Bimode CO2 Laser with Saturable Absorber * Chaotic Homoclinic Phenomena in Opto-Thermal Devices * Observation and Characterisation of Low-Frequency Chaos in Semiconductor Lasers with External Feedback * Condensed Matter * The Application of Nonlinear Dynamics in the Study of Ferroelectric Materials * Cellular Convection in a Small Aspect Ratio Liquid Crystal Device * Driven Spin-Wave Dynamics in YIG Films * Quantum Chaology in Quartz * Small Signal Amplification Caused by Nonlinear Properties of Ferroelectrics * Composite Materials Evolved from Chaos * Electronics and Circuits * Controlling a Chaotic Array of Pulse-Coupled Fitzhugh-Nagumo Circuits * Experimental Observation of On-Off Intermittency * Phase Lock-In of Chaotic Relaxation Oscillators * Biology and Medicine * Singular Value Decomposition and Circuit Structure in Invertebrate Ganglia * Nonlinear Forecasting of Spike Trains from Neurons of a Mollusc * Ultradian Rhythm in the Sensitive Plants: Chaos or Coloured Noise? * Chaos and the Crayfish Sixth Ganglion * Hardware Coupled Nonlinear Oscillators as a Model of Retina

  2. In Search of a Future. 3rd Edition, November 1976.

    ERIC Educational Resources Information Center

    Fulham, Stanley A.

    Describing the increasing numbers of Canada Natives who must reconcile the conflict arising from the economic necessity to migrate and the emotional necessity to stay in Manitoba's rural areas, this book identifies the following problems facing the rural to urban Canada Native migrant: lack of adequate housing; lack of finances; deficiency in…

  3. Prediction of Grade of Dropout from 3rd Grade Data.

    ERIC Educational Resources Information Center

    Lloyd, Dee Norman; Bleach, Gail

    Measures of background characteristics, school performance, and test achievement were analyzed for four race-by-sex samples of third graders who were known to have later become high school dropouts. In each sample, age in the third grade, course marks, and standardized achievement scores were found to be significantly related to the grade in which…

  4. Curriculum Based Assessment: A Primer. 3rd Edition

    ERIC Educational Resources Information Center

    Hargis, Charles H.

    2004-01-01

    The use of curriculum based assessment (CBA) to ensure learning disabled and low achieving students adequate educational opportunity remains the focus in this direct and comprehensive third edition. The additions to this edition are in the way of providing detail and explanation in the context of current and emerging issues in educational…

  5. Hospitals, nursing homes turn to 3rd-party financing

    SciTech Connect

    Slaff, J.

    1982-07-05

    Experience is teaching the administrators of hospitals and nursing homes how to make better arrangements for third-party financing of energy-management systems. Accustomed to health-insurance reimbursement for health-care costs, hospitals have lacked incentives for conservation. Plans now used most by hospitals and health-care facilities involve third-party arrangements where: (1) an equipment vendor installs equipment and takes a share of the energy-cost savings; or (2) energy-services firms both install capital-intensive equipment and implement a variety of low-cost conservation measures, again for a percentage of the savings. Although most users think these arrangements are satisfactory, they advise a preliminary low-cost audit and participation in a basic energy-management seminar before employing an energy-services firm. Accurate baseline energy-consumption data should be developed in order to evaluate results, and assurance is needed that staff members understand the accounting formulas. Also recommended are independent audits after installation and attention to the legal clauses in contracts. (DCK)

  6. [Neurology in the "3rd Reich" and consequences].

    PubMed

    Peiffer, J

    1998-08-01

    This review of German neurology during the Nazi era mentions first the significance of Jewish neurologists for the history of the specialty, and the irreplaceable loss that their expulsion from Germany represented. A brief discussion of the scientific accomplishments of German neurologists during this time is followed by a description of violations of ethical principles, exemplified by the human experiments of G. Schaltenbrand. The spirit of the age exerted a malevolent influence. PMID:9757428

  7. Basic imaging in congenital heart disease. 3rd Ed

    SciTech Connect

    Swischuk, L.E.; Sapire, D.W.

    1986-01-01

    The book retains its previous format with chapters on embryology, plain film interpretation, classification of pulmonary vascular patterns, cardiac malpositions and vascular anomalies, and illustrative cases. The book is organized with an abundance of illustrative figures, diagrams, and image reproductions. These include plain chest radiographs, angiograms, echocardiograms, and MR images. The authors present the pathophysiology and imaging of congenital heart lesions.

  8. Studies on Metadiscourse Since the 3rd Millennium

    ERIC Educational Resources Information Center

    Wei, Jing; Li, Yan; Zhou, Ting; Gong, Zhiwei

    2016-01-01

    Metadiscourse refer to linguistic resources that are used to refer to the act and the context of writing about some subject matter. Study of metadiscourse provides a gateway for understanding interactional features of texts or speech, looking beyond the ideational dimension of texts at how writers characterize the world and function…

  9. Pet Care Teaching Unit: 1st-3rd Grades.

    ERIC Educational Resources Information Center

    Peninsula Humane Society, San Mateo, CA.

    Activities in this unit are designed to familiarize primary grade students with the responsibilities involved in pet ownership. Teaching plans are provided for a total of 12 lessons involving social studies, language arts, math, and health sciences. Activities adaptable for readers and non-readers focus on pet overpopulation, care of pets when…

  10. Discipline with Dignity, 3rd Edition: New Challenges, New Solutions

    ERIC Educational Resources Information Center

    Curwin, Richard L.; Mendler, Allen N.; Mendler, Brian D.

    2008-01-01

    Since 1988, this landmark publication has given thousands of teachers timeless advice on not only how to prevent and solve discipline problems but also how to teach discipline as an affirming approach that promotes respect for self and others. Now this expanded 20th Anniversary Edition extends the authors' wisdom to new principles for coping with…

  11. NS&T Management Observations - 3rd Quarter

    SciTech Connect

    David Gianotto

    2014-07-01

    The INL Management Observation Program (MOP) is designed to improve managers and supervisors understanding of work being performed by employees and the barriers impacting their success. The MOP also increases workers understanding of managements’ expectations as they relate to safety, security, quality, and work performance. Management observations are designed to improve the relationship and trust between employees and managers through increased engagement and interactions between managers and researchers in the field. As part of continuous improvement, NS&T management took initiative to focus on the participation and quality of observations in FY 14. This quarterly report is intended to (a) summarize the participation and quality of management’s observations, (b) assess observations for commonalities or trends related to facility or process barriers impacting research, and (c) provide feedback and make recommendations for improvements NS&T’s MOP.

  12. Resource Guide to Careers in Toxicology, 3rd Edition.

    ERIC Educational Resources Information Center

    Society of Toxicology, Reston, VA.

    This resource guide was prepared by the Tox 90's Educational Issues Task Force of the Society of Toxicology. The introduction provides information on the Society of Toxicology and financial support for graduate students in toxicology. Other sections include career opportunities in toxicology, academic and postdoctoral programs in toxicology, and…

  13. 3rd International Conference on Turbulent Mixing and Beyond

    NASA Astrophysics Data System (ADS)

    Abarzhi, Snezhana I.; Gauthier, Serge; Keane, Christopher J.; Niemela, Joseph J.

    2013-07-01

    1. Introduction 'Turbulent Mixing and Beyond' (TMB) is the programme established for scientists, by scientists. It is merit-based, and is shaped by requirements of academic credentials, and novelty and quality of information. The goals of this programme are to expose the generic problem of non-equilibrium turbulent processes to a wide scientific community, to promote the development of new ideas in tackling the fundamental aspects of the problem, to assist in application of novel approaches in a broad range of phenomena, in which the turbulent processes occur, and to have a potential impact on technology. The programme was founded in 2007 with the support of the international scientific community and of the US National Science Foundation, the US Air Force Office of the Scientific Research and its European Office for Research and Development in the UK, the UNESCO-IAEA International Centre for Theoretical Physics in Italy, the Commissariat l'Energie Atomique in France, the US Department of Energy and the Department of Energy National Laboratories, the Institute for Laser Engineering in Japan, and the University of Chicago in the USA. The International Conference on Turbulent Mixing and Beyond provides opportunities to bring together researchers from the areas, which include but are not limited to, fluid dynamics, plasmas, high energy density physics, astrophysics, material science, combustion, atmospheric and earth sciences, nonlinear and statistical physics, applied mathematics, probability and statistics, data processing and computations, optics and communications, and to have their attention focused on the long-standing formidable task of non-equilibrium turbulent processes. 2. Non-equilibrium turbulent processes Non-equilibrium turbulent processes play a key role in a wide variety of phenomena, ranging from astrophysical to atomistic scales, under either high or low energy density conditions. Inertial confinement and magnetic fusion, light-matter interaction and non-equilibrium heat transfer, strong shocks and explosions, material transformation under high strain rate, supernovae and accretion discs, stellar non-Boussinesq and magneto-convection, planetary interiors and mantle-lithosphere tectonics, premixed and non-premixed combustion, non-canonical wall-bounded flows, hypersonic and supersonic boundary layers, dynamics of atmosphere and oceanography, are just a few examples to list. A grip on non-equilibrium turbulent processes is crucial for cutting-edge technology such as laser micro-machining, nano-electronics, free-space optical telecommunications and for industrial applications in the areas of aeronautics and aerodynamics. Non-equilibrium turbulent processes are anisotropic, non-local, multi-scale and multi-phase, and often are driven by shocks or acceleration. Their scaling, spectral and invariant properties differ substantially from those of classical Kolmogorov turbulence. At atomistic and meso-scales, the non-equilibrium dynamics depart dramatically from a standard scenario given by Gibbs statistic ensemble average and quasi-static Boltzmann equation. The singular aspect and the similarity of the non-equilibrium dynamics at macroscopic scales are interplayed with the fundamental properties of the Euler and compressible Navier-Stokes equations and with the problem sensitivity to the boundary conditions at discontinuities. The state-of-the-art numerical simulations of multi-phase flows suggest new methods for predictive modelling of the multi-scale non-equilibrium dynamics in fluids and plasmas, for error estimates and uncertainty quantifications, as well as for novel data assimilation techniques. 3. International Conference 'Turbulent Mixing and Beyond' The First and Second International Conferences on Turbulent Mixing and Beyond found that: (i) TMB-related problems have in common a set of outstanding research issues; (ii) their solution has a potential to significantly advance a variety of disciplines in science, technology and mathematics; (iii) TMB participants conduct highly innovative research and their interactions strengthen the community's might. Based on the success of the first and second conferences and on the recommendations of the conference round table discussions, and in response to the inquiry of the community, the Third International Conference on Turbulent Mixing and Beyond was organized. The Third International Conference on Turbulent Mixing and Beyond, TMB-2011, was held on 21-28 August 2011 at the Abdus Salam International Centre for Theoretical Physics (ICTP), Trieste, Italy. This was a highly informative and exciting meeting, and it strengthened and reaffirmed the success of TMB-2009 and 2007. The objectives of the Third International Conference on Turbulent Mixing and Beyond were to: (i) focus the integration of theory, experiments, large-scale numerical simulations and state-of-the-art technologies on the exploration of physical mechanisms of non-equilibrium dynamics, from micro to macro-scales, in both high and low energy density regimes; (ii) foster the application of innovative approaches for tackling the fundamental aspects of turbulent mixing problems and for understanding and further extending the range of applicability of canonical considerations; (iii) encourage the development of new approaches and stimulate the application of advanced data analysis techniques for unified characterization of experimental and numerical data sets, for estimation of their quality and information capacity, and for transforming data to knowledge; (iv) further develop the 'Turbulent Mixing and Beyond' community via organizing a positive and constructive collaborative environment, maintaining the quality of information flux in the community and sharing research methodologies, tools and data among the community members. The objectives were accomplished at TMB-2011. 4. Programme of TMB-2011 TMB-2011 brought together 150 participants, ranging from students to members of National Academies of Sciences and Engineering, and including researchers at experienced and early stages of their careers from leading scientific institutions in academia, national laboratories, corporations and industry, from developed and developing countries across five continents. The success of TMB-2011 consisted from the successful work of the conference participants, who were responsible professionals caring for the quality of their research and sharing their scientific vision. The level of presentations was high, and 205 presentations included about 50 invited lectures, nearly 70 oral talks (3500 min of talks in total), some 90 posters and one round table. The special course on 'Turbulence and Waves' was organized at TMB-2011 with the support of the US Office of Naval Research Global, and included nearly 40 lectures and talks (960 minutes of talks in total). TMB-2011 covered 16 different topics, maintaining the scope and the interdisciplinary character of the meeting and at the same time keeping the focus on a fundamental scientific problem of non-equilibrium processes and on the conference objectives. The topics included: • Canonical turbulent and turbulent mixing: invariant, scaling, spectral properties, scalar transports, convection. • Wall-bounded flows: structure and fundamentals, non-canonical turbulent boundary layers, including unsteady and transitional flows, supersonic and hypersonic flows, shock-boundary layer interactions. • Non-equilibrium processes: unsteady, multiphase and shock-driven turbulent flows, anisotropic non-local dynamics, connection of continuous description at macro-scales to kinetic processes at atomistic scales. • Interfacial dynamics: the instabilities of Rayleigh-Taylor, Kelvin-Helmholtz, Richtmyer-Meshkov, Landau-Darrieus, Saffmann-Taylor. • High energy density physics: inertial confinement and heavy-ion fusion, Z-pinches, light-material and laser-plasma interaction, non-equilibrium heat transfer. • Material science: material transformation under high strain rates, equation of state, impact dynamics, mixing at nano- and micro-scales. • Astrophysics: supernovae, interstellar medium, star formation, stellar interiors, early Universe, cosmic-microwave background, accretion discs. • Magneto-hydrodynamics: magnetic fusion and magnetically confined plasmas, magneto-convection, magneto-rotational instability, dynamo. • Canonical plasmas: coupled plasmas, anomalous resistance, ionosphere. • Physics of atmosphere: environmental fluid dynamics, forecasting, turbulent flows in stratified media and atmosphere. • Geophysics and Earth science: mantle-lithosphere tectonics, oceanography, turbulent convection under rotation, planetary interiors. • Combustion: dynamics of flames and fires, deflagration-to-detonation transition, blast waves and explosions, flows with chemical reactions, reactive flows in jet engines. • Theoretical aspects of non-equilibrium dynamics: vortex dynamics, singularities, discontinuities, asymptotic dynamics, weak solutions, well- and ill-posedness, continuous transports out of thermodynamic equilibrium. • Stochastic processes and probabilistic description: long-tail distributions and anomalous diffusion, data assimilation and processing methodologies, error estimate and uncertainty quantification, statistically unsteady processes. • Advanced numerical simulations: continuous DNS/LES/RANS, molecular dynamics, Monte-Carlo, predictive modelling, validation and verification of numerical models. • Experiments and experimental diagnostics: model experiments in high energy density and low energy density regimes, plasma diagnostics, fluid flow visualizations and control, opto-fluidics, novel optical method, holography, advanced technologies. The abstracts of the 207 accepted presentations of 443 authors were published in Proceedings. Abstracts. The Third International Conference 'Turbulent Mixing and Beyond', 21 -28 August 2011. Copyright (ISBN 92-95003-45-4). All the accepted contributions have been reviewed by the international team of 27 members of the Scientific Committee, with every contribution considered by four to eleven experts. In the majority of cases, the opinions of referees with diverse backgrounds and expertise converged. In 2011, the award 'Turbulent Mixing and Beyond for Youth' was issued to Gregory P Bewley (Max Plank Institute for Dynamics and Self-Organization, Germany) and Robert Zimmermann (Ecole Normale Superieure de Lyon, France) in recognition of their contributions to TMB-related scientific problems. The Best Poster Award was issued by Physica Scripta to Michael Winkler (University of Potsdam, Germany) in recognition of their poster presentation at TMB-2011. 5. Organization and acknowledgments The Third International Conference on Turbulent Mixing and Beyond was organized by the following members of the Organizing Committee: • Snezhana I Abarzhi (Chairperson, University of Chicago, USA) • Malcolm J Andrews (Los Alamos National Laboratory, USA) • Hiroshi Azechi (Institute for Laser Engineering, Osaka, Japan) • Vladimir E Fortov (Institute for High Energy Density, Russia) • Boris Galperin (Organizer of the Special Course, University of South Florida, USA) • Serge Gauthier (Commissariat à l'Energie Atomique, France) • Christopher J Keane (Lawrence Livermore National Laboratory, USA) • Joseph J Niemela (Local Organizer, International Centre for Theoretical Physics, Italy) • Katepalli R Sreenivasan (New York University, USA) The conference and course were sponsored by several agencies and institutions in the USA, Europe, Russia and Japan. The Organizing Committee of the TMB-2011 gratefully acknowledges support of the: • National Science Foundation (NSF), USA. Programmes: Plasma Physics; Physics Education and Interdisciplinary Research; Astronomy and Astrophysics; Applied Mathematics; Particulate and Multiphase Processes; Combustion, Fire and Plasma Systems • European Office of Aerospace Research and Development (EOARD), UK, of the Air Force Office of Scientific Research (AFOSR), USA • Office of Naval Research Global, UK • Department of Energy, Office of Science, USA • US Department of Energy Lawrence Livermore National Laboratory (LLNL), USA. Programme: National Ignition Facility (NIF) • US Department of Energy Argonne National Laboratory (ANL), USA • US Department of Energy Los Alamos National Laboratory (LANL), USA • The UNESCO- IAEA International Centre for Theoretical Physics (ICTP), Italy • Commissariat à l'Énergie Atomique et aux énergies Alternatives (CEA), France • The University of Chicago, USA • Institute for Laser Engineering (ILE), Japan • Joint Institute for High Temperatures (JIHT) of the Academy of Sciences, Russia • Institute of Physics Publishing (IOP), UK • Physica Scripta , the journal of the Royal Swedish Academy of Sciences for the Science Academies and the Physical Societies of the Nordic Countries and thank them for making this event possible. We express our gratitude to the members of the Scientific Advisory Committee: • S I Abarzhi (University of Chicago, USA) • Y Aglitskiy (Science Applications International Corporation, USA) • H Azechi (Institute for Laser Engineering, Osaka, Japan) • M J Andrews (Los Alamos National Laboratory, USA) • S I Anisimov (Landau Institute for Theoretical Physics, Russia) • E Bodenschatz (Max Plank Institute, Germany) • F Cattaneo (University of Chicago, USA) • P Cvitanović (Georgia Institute of Technology, USA) • S Cowley (Imperial College, UK) • S Dalziel (DAMTP, Cambridge, UK) • R Ecke (Los Alamos National Laboratory, USA) • H J Fernando (University of Notre Dame, USA) • Y Fukumoto (Kyushu University, Japan) • B Galperin (University of South Floorida, USA) • S Gauthier (Commissariat à l'Energie Atomique, France) • W Gekelman (University of California, Los Angeles, USA) • G A Glatzmaier (University of California at Santa Cruz, USA) • J Glimm (State University of New York at Stony Brook, USA) • W A Goddard III (California Institute of Technology, USA) • F Grinstein (Los Alamos National Laboratory, USA) • J Jimenez (Universidad Politecnica de Madrid, Spain) • L P Kadanoff (The University of Chicago, USA) • D Q Lamb (The University of Chicago, USA) • D P Lathrop (University of Maryland, USA) • S Lebedev (Imperial College, UK) • P Manneville (Ecole Polytechnique, France) • D I Meiron (California Institute of Technology, USA) • P Moin (Stanford University, USA) • A Nepomnyashchy (Technion, Israel) • J Niemela (International Center for Theoretical Physics, Italy) • K Nishihara (Institute for Laser Engineering, Osaka, Japan) • S S Orlov (Physical Optics Corporation, USA) • N Peters (RWTS, Aachen, Germany) • S B Pope (Cornell, USA) • A Pouquet (University Corporation for Atmospheric Research, USA) • B A Remington (Lawrence Livermore National Laboratory, USA) • R R Rosales (Massachusetts Institute of Technology, USA) • R Rosner (Argonne National Laboratory and University of Chicago, USA) • A J Schmitt (Naval Research Laboratory, USA) • C-W Shu (Brown University, USA) • K R Sreenivasan (New York University, USA) • E Tadmor (University of Maryland, USA) • A L Velikovich (Naval Research Laboratory, USA) • V Yakhot (Boston University, USA) • P K Yeung (Georgia Institute of Technology, USA) • F A Williams (University of California at San Diego, USA) • E Zweibel (University of Wisconsin, USA) We deeply appreciate the work of the Members of Steering Committee for Financial Support: • Snezhana I Abarzhi (University of Chicago, USA) • Serge Gauthier (Commissariat à l'Energie Atomique, France) • Joseph J Niemela (International Centre for Theoretical Physics, Italy) • Walter Gekelman (University of California, Los Angeles, USA) We thank the members of the Committee for the award 'Turbulent Mixing and Beyond for Youth': • Boris Galperin (University of South Florida, USA) • Serge Gauthier (Commissariat à l'Energie Atomique, France) • Joseph J Niemela (International Centre for Theoretical Physics, Italy) • Katsunobu Nishihara (Institute for Laser Engineering, Osaka, Japan) • Katepalli R Sreenivasan (New York University, USA) We greatly acknowledge the effort and dedication of the members of the Committee for Best Poster Award: • Serge Gauthier (Commissariat à l'Energie Atomique, France) • Katsunobu Nishihara (Institute for Laser Engineering, Osaka, Japan) • Annick Pouquet (National Center for Atmospheric Research, USA) • Walter Gekelman (University of California, Los Angeles, USA) • Graeme Watt (Institute of Physics, UK) We greatly appreciate the work of conference web-master Daniil V Ilyin (University of Chicago, USA). We thank for technical support: • Bhanesh Akula (Texas A & M University, USA) • Ahmad Qamar (University of Chicago, USA) We warmly acknowledge the logistics assistance of the offices and officers of the Abdus Salam International Centre for Theoretical Physics: • Conference Support Office, and Ms Katrina Danforth and Ms Daniela Giombi • Financial Office, and Mr Andrej Michelcich and Ms Alessandra Ricci • Visa Office, and Mr Erich Jost and Mr Adriano Maggio • Housing Office, and Ms Tiziana Bottazzi and Ms Dora Photiou • Publications Office, and Mr Guido Comar and Mr Raffaele Corona • Computer Office, and Dr Johannes Grassberger • Science Dissemination Unit, and Dr Enrique Canessa, Dr. Carlo Fonda and Dr Marco Zennaro We gratefully appreciate the support of the members of the Programme Coordination Board: • Snezhana I Abarzhi (University of Chicago, USA) • Malcolm J Andrews (Los Alamos National Laboratory, USA) • Sergei I Anisimov (Landau Institute for Theoretical Physics, Russia) • Hiroshi Azechi (Institute for Laser Engineering, Osaka, Japan) • Vladimir E Fortov (Institute for High Energy Density, Russia) • Serge Gauthier (Commissariat à l'Energie Atomique, France) • Christopher J Keane (Lawrence Livermore National Laboratory, USA) • Joseph J Niemela (International Centre for Theoretical Physics, Italy) • Katsunobu Nishihara (Institute for Laser Engineering, Osaka, Japan) • Sergei S Orlov (Physical Optics Corporation, USA) • Bruce Remington (Lawrence Livermore National Laboratory, USA) • Robert Rosner (University of Chicago, USA) • Katepalli R Sreenivasan (New York University, USA) • Alexander L Velikovich (Naval Research Laboratory, USA) 6. The Topical Issue This Topical Issue consists of over 70 articles accepted for publication and represents a substantial part of the Conference contributions, including research papers, research briefs and review papers. The papers are in a broad variety of TMB-2011 themes and are sorted alphabetically by the last name of the first author within each topic. The review papers are published as 'Comments' articles in Physica Scripta . We thank all the authors and the referees for their contributions to this Topical Issue and for offering their expertise, time and effort. To conclude, the TMB programme was organized to serve to advance the state-of-the-art in understanding of fundamental physical properties of non-equilibrium turbulent processes and to have an impact on predictive modelling capabilities, physical description and, ultimately, control of these complex processes. The readers are cordially invited to take a look at this Topical Issue for information on the frontiers of theoretical, numerical and experimental research, and state-of-the-art technology. Welcome to 'Turbulent Mixing and Beyond'.

  14. Low efficiency gratings for 3rd harmonic diagnostics applications

    SciTech Connect

    Britten, J.A.; Boyd, R.D.; Perry, M.D.; Shore, B.W.; Thomas, I.M.

    1995-08-09

    The baseline design of the National Ignition Facility (NIF) calls for sampling gratings to provide third-harmonic energy diagnostics in the highly constrained area of the target chamber. These 40 {times} 4O cm transmission gratings are to diffract at (order +1) nominally 0.3% of the incident 351 run light at a small angle on to a focusing mirror and into a calorimeter. The design calls for a plane grating of 500 lines/mm, and approximately 30 run deep, etched into a fused silica focusing lens and subsequently overcoated with a solgel anti reflective coating. Gratings of similar aperture and feature size have been produced for other applications by ion etching processes, but, in an effort to reduce substantially the cost of such optics, we are studying the feasibility of making these gratings by wet chemical etching techniques. Experimentation with high-quality fused silica substrates on 5 and 15 cm. scale has led to a wet etching process which can meet the design goals and which offers no significant scaleup barriers to full sized optics. The grating is produced by holographic exposure and a series of processing steps using only a photoresist mask and a final hydrofluoric acid etch. Gratings on 15 cm diameter test substrates exhibit absolute diffraction efficiencies from 0.2--0.4% with a standard deviation of about 15% of the mean over the full aperture. The efficiency variation is due to variation in linewidth caused by spatial nonuniformities in exposure energy. Uniformity improvements can be realized by using a smaller, more uniform portion of the exposure beam and exposing for longer times. The laser damage threshold for these gratings has been measured at LLNL and found to be identical to that of the fused silica substrate.

  15. Ethnic Orange County: An Ethnic Resources Directory. 3rd Edition.

    ERIC Educational Resources Information Center

    Garcia-Ayvens, Francisco, Comp.

    Designed to assist libraries and other agencies in their efforts to provide current referral services to local groups and agencies serving minority populations, this directory reflects the diverse nature of Orange County's population and identifies resources to help support their basic needs. Limited to the four largest minority groups (Asian…

  16. [Infant Mortality in Argentina: reducibility criteria, 3rd review].

    PubMed

    Finkelstein, Juliana Zoe; Duhau, Mariana; Abeyá Gilardon, Enrique; Ferrario, Claudia; Speranza, Ana; Asciutto, Carolina; Marconi, Élida; Guevel, Carlos; Fernández, María de las Mercedes; Martínez, María Laura; Santoro, Adrián; Loiacono, Karina; Lomuto, Celia

    2015-08-01

    The infant mortality rate is an indicator of quality of life, development, and quality and accessibility of health care. Improvements in science, technology and better access to health care have contributed to a major decrease in the infant mortality rate in Argentina. Since the 1980s, infant deaths have been classified based on the opportunities for reducibility yielded by scientific knowledge and available technologies, in order to obtain a basis for the monitoring and implementation of health policies. The last review of this classification was in 2011. In 2012, a total of 5,541 neonatal deaths (less than 28 days of life) were registered and, under this new classification, over 61% were reducible mainly by the improvement of perinatal health care and adequate and timely treatment of the at-risk newborn. In 2012, a total of 2,686 post-neonatal deaths (from 28 days of life to a year) were registered and, under this new classification, over 66.8% were reducible by improving prevention strategies and providing adequate and timely treatment. This new analysis demonstrates the need to improve the opportunity, accessibility and quality of perinatal care starting at pregnancy, guaranteeing quality care at delivery and reinforcing prevention and timely treatment of common diseases in childhood over the first year of life. PMID:26172012

  17. Developmental Surface and Phonological Dysgraphia in German 3rd Graders

    ERIC Educational Resources Information Center

    Cholewa, Jurgen; Mantey, Stefanie; Heber, Stefanie; Hollweg, Wibke

    2010-01-01

    The investigation of developmental reading and spelling disorders within the framework provided by cognitive neuropsychology has yielded interesting results for several alphabetic orthographies, for example English, Italian, and French. However, this approach has not attracted much attention in German speaking countries up to now. The following…

  18. Thermodynamic Study of UO3(g), UO2(OH)2(g), UO2Cl2(g), and UO2F2(g)

    SciTech Connect

    Ebbinghaus, B B; Krikorian, O H; Fleming, D L

    2002-11-07

    Using the transpiration method, the volatility of uranium oxide in the presence of oxygen and water vapor has been measured at temperatures ranging from 1173 to 1573 K and the volatility of uranium oxide in the presence of oxygen and chlorine has been measured at 1175 K. The major vapor species in the presence of oxygen and water vapor are found to be UO{sub 3}(g) and UO{sub 2}(0H){sub 2}(g). Third law treatment of the vaporization data yields {Delta}H{sub f}{sup o}(298) values of -790.52 {+-} 7.32 and -1199.94 {+-} 10.25 kJ/mol, respectively. The major vapor species in the presence of oxygen and chlorine is found to be UO{sub 2}Cl{sub 2}(g). Third law treatment of the vaporization data yields a {Delta}H{sub f}{sup o}(298) value of -1002.04 {+-} 3.26 kJ/mol. From an assessment of all the thermodynamic data available for UO{sub 3}(g), UO{sub 2}(OH){sub 2}(g), UO{sub 2}Cl{sub 2}(g), and UO{sub 2}F{sub 2}(g), the best {Delta}H{sub f{sup o}}(298) values for each of these species are calculated to be -796.74 {+-} 3.52, -1199.94 {+-} 10.25, -999.64 {+-} 2.40, and -1369.22 {+-} 2.87 kJ/mol, respectively. From these, the {Delta}H{sub f{sup o}} (298) values for UO{sub 2}ClOH(g), UO{sub 2}FOH(g), and UO{sub 2}FCl(g) are estimated to be -1099.79, -1284.58, and -1184.43 kJ/mol, respectively. The thermodynamic data for all the vapor species are then applied to conditions one might expect in a thermal oxidation processor for mixed waste to estimate the amount of uranium volatility.

  19. Diabetes risk in older Mexican Americans: effects of language acculturation, generation and socioeconomic status.

    PubMed

    Afable-Munsuz, Aimee; Gregorich, Steven E; Markides, Kyriakos S; Pérez-Stable, Eliseo J

    2013-09-01

    The effect of language acculturation, socioeconomic status (SES), and immigrant generation on development of diabetes among Mexican Americans was evaluated in the Hispanic Established Population for the Epidemiologic Study of the Elderly (HEPESE). HEPESE is a longitudinal cohort study of 3,050 non-institutionalized Mexican Americans aged 65 years at baseline (1993-1994) from 5 Southwestern states. Diabetes incidence was ascertained in 4 follow-up surveys to 2004-05 by respondent self-reported physician-diagnosis of diabetes, high blood glucose, or sugar in the urine. Language of interview, immigrant generation, gender, age, education, family history of diabetes, smoking status, alcohol use, health insurance type and self-reported height and weight were assessed. High socioeconomic status (SES) was defined by high school graduation and non-Medicaid insurance. Cox's proportional hazards models were fit to evaluate the effects of language acculturation, generation and SES on incident diabetes. 845 of 3,050 (27.7%) Mexican Americans had diabetes at baseline and were younger, more educated, and more likely to have health insurance than those without diabetes. Risk of developing diabetes increased for Spanish-speaking respondents with low SES from 1st to 3rd generation (HR = 1.76, 95% CI = 1.02-3.03) and from 2nd to 3rd generation (HR = 2.15, 95% CI = 1.20-3.84). Among English-speaking, high SES participants, generation had a protective effect on developing diabetes: HR = 0.45 (95% CI = 0.22-0.91) when comparing 3rd versus 1st generation. The effect of language acculturation and immigrant generation on incident diabetes is moderated by SES status in HEPESE participants. PMID:23990075

  20. Genetics of Glucose regulation in Gestation and Growth (Gen3G): a prospective prebirth cohort of mother–child pairs in Sherbrooke, Canada

    PubMed Central

    Guillemette, Laetitia; Allard, Catherine; Lacroix, Marilyn; Patenaude, Julie; Battista, Marie-Claude; Doyon, Myriam; Moreau, Julie; Ménard, Julie; Bouchard, Luigi; Ardilouze, Jean-Luc; Perron, Patrice; Hivert, Marie-France

    2016-01-01

    Purpose We initiated the Genetics of Glucose regulation in Gestation and Growth (Gen3G) prospective cohort to increase our understanding of biological, environmental and genetic determinants of glucose regulation during pregnancy and their impact on fetal development. Participants Between January 2010 and June 2013, we invited pregnant women aged ≥18 years old who visited the blood sampling in pregnancy clinic in Sherbrooke for their first trimester clinical blood samples: 1034 women accepted to participate in our cohort study. Findings to date At first and second trimester, we collected demographics and lifestyle questionnaires, anthropometry measures (including fat and lean mass estimated using bioimpedance), blood pressure, and blood samples. At second trimester, women completed a full 75 g oral glucose tolerance test and we collected additional blood samples. At delivery, we collected cord blood and placenta samples; obstetrical and neonatal clinical data were abstracted from electronic medical records. We also collected buffy coats and extracted DNA from maternal and/or offspring samples (placenta and blood cells) to pursue genetic and epigenetic hypotheses. So far, we have found that low adiponectin and low vitamin D maternal levels in first trimester predict higher risk of developing gestational diabetes. Future plans We are now in the phase of prospective follow-up of mothers and offspring 3 and 5 years postdelivery to investigate the consequences of maternal dysglycaemia during pregnancy on offspring adiposity and metabolic profile. Trial registration number NCT01623934. PMID:26842272

  1. Fabrication of CoTiO3/g-C3N4 Hybrid Photocatalysts with Enhanced H2 Evolution: Z-Scheme Photocatalytic Mechanism Insight.

    PubMed

    Ye, RongQin; Fang, HuaBin; Zheng, Yan-Zhen; Li, Nan; Wang, Yuan; Tao, Xia

    2016-06-01

    A novel direct Z-scheme CoTiO3/g-C3N4 (CT-U) photocatalytic system with different weight percentage of CoTiO3 was synthesized using a facile in situ growth method for H2 evolution from water splitting. The as-prepared CT-U composites composed of 1D CoTiO3 microrod and 2D g-C3N4 nanosheet were characterized by various techniques including XRD, SEM, TEM, XPS, FTIR, and UV-vis. Results demonstrate that the CT-U composite photocatalysts were successfully fabricated, with intimate interfacial contact and heterojunction interaction between g-C3N4 and CoTiO3 which can significantly boost the photocatalytic activity compared with prinstine g-C3N4 and CoTiO3. The most enhanced H2-evolution rate of 858 μmol h(-1) g(-1) and high quantum efficiency (38.4% at 365 nm, 3.23% at 420 ± 20 nm) are achieved at an optimal 0.15% CT-U. Meanwhile, the 0.15% CT-U sample exhibits good photocatalytic stability in recycling H2 evolution. Accordingly, direct Z-scheme mechanism capable of leading efficient charge carrier separation and strong reduction ability for enhanced H2 production was proposed, and further evidenced by PL, photoelectrochemical analysis, and ESR assay. PMID:27180943

  2. The Analysis of the Possible Thermal Emission at Radio Frequencies from an Evolved Supernova Remnant HB 3 (G132.7+1.3): Revisited

    NASA Astrophysics Data System (ADS)

    Onic, D.; Urosevic, D.

    2008-12-01

    It has recently been reported that some of the flux density values for an evolved supernova remnant (SNR) HB 3 (G132.7+1.3) are not accurate enough. In this work we therefore revised the analysis of the possible thermal emission at radio frequencies from this SNR using the recently published, corrected flux density values. A model including the sum of non-thermal (purely synchrotron) and thermal (bremsstrahlung) components is applied to fit the integrated radio spectrum of this SNR. The contribution of thermal component to the total volume emissivity at 1 GHz is estimated to be ≈37 %. The ambient density is also estimated to be n≈ 9 {cm}^{-3} for {T}=10^{4} {K}. Again we obtained a relatively significant presence of thermal emission at radio frequencies from the SNR, which can support interaction between SNR HB 3 and adjacent molecular cloud associated with the H II region W3. Our model estimates for thermal component contribution to total volume emissivity at 1 {GHz} and ambient density are similar to those obtained earlier (≈40 %, ≈10 {cm^{-3}}). It is thus obvious that the corrected flux density values do not affect the basic conclusions.

  3. Fidelity of binding of the guanidinium nucleic acid (DNG) d(Tg)4-T-azido with short strand DNA oligomers (A5G3A5, GA4G3A4G, G2A3G3A3G2, G2A2G5A2G2). A kinetic and thermodynamic study.

    PubMed

    Blaskó, A; Minyat, E E; Dempcy, R O; Bruice, T C

    1997-06-24

    Short strand DNA oligomers (A5G3A5, GA4G3A4G, G2A3G3A3G2, and G2A2G5A2G2) and the guanidinium (g) linked thymidyl nucleoside d(Tg)4-T-azido associate as triplexes. The melting temperatures, Tm, the association and dissociation kinetic and thermodynamic parameters and activation energies for the triplexes were determined by UV thermal analysis. The hypochromic shift and Tm for triplex formation increases with increase in concentration and decreases with the number of mismatches. The melting temperatures are between 35 and 55 degrees C in the range of ionic strength of 0.06-0.24 and decrease with increase in ionic strength at 100 deg/(ionic strength unit). The melting and cooling curves exhibit hysteresis behavior in the temperature range 5-95 degrees C at 0.2 deg/min thermal rate. From these curves, the rate constants and the energies of activation for association (k(on), E(on)) and dissociation (k(off), E(off)) processes were obtained. The second-order rate constants, k(on), for the triplex formation at 288 K are between 10 and 500 M(-2) s(-1). Values of k(on) increase with the decrease in the ionic strength. The first order rate constants for the dissociation, k(off), at 288 K are between 10(-6) and 40 x 10(-6) s(-1) and increase with increase in ionic strength. The energies of activation for the association and dissociation processes are in the range -22 to -9 kcal/mol and 8 to 29 kcal/mol, respectively. At 6.3 x 10(-5) M/base and at the physiological ionic strength (0.15-0.30) and below, the triplex structures formed with d(Tg)4-T-azido and A5G3A5 and GA4G3A4G have well-defined Tm values. The melting curves with G2A3G3A3G2 and G2A2G5A2G2 are very shallow with small hypochromic shifts denoting negligible binding at physiological ionic strength. Therefore, with the increase in the G content (mismatched base pairs) at a certain concentration (e.g., 6.3 x 10(-5) M/base), discrimination (change in fidelity) occurs in the formation and strength of binding of d(Tg)4-T

  4. Demonstration of the Echo-Enabled Harmonic Generation Technique for Short-Wavelength Seeded Free Electron Lasers

    SciTech Connect

    Xiang, D.; Colby, E.; Dunning, M.; Gilevich, S.; Hast, C.; Jobe, K.; McCormick, D.; Nelson, J.; Raubenheimer, T. O.; Soong, K.; Stupakov, G.; Szalata, Z.; Walz, D.; Weathersby, S.; Woodley, M.; Pernet, P.-L.

    2010-09-10

    We report the first experimental demonstration of the echo-enabled harmonic generation technique, which holds great promise for generation of high-power, fully coherent short-wavelength radiation. In this experiment, coherent radiation at the 3rd and 4th harmonics of the second seed laser is generated from the so-called beam echo effect. The experiment confirms the physics behind this technique and paves the way for applying the echo-enabled harmonic generation technique for seeded x-ray free electron lasers.

  5. Characterization of the Deamination Coupled with Sliding along DNA of Anti-HIV Factor APOBEC3G on the Basis of the pH-Dependence of Deamination Revealed by Real-Time NMR Monitoring

    PubMed Central

    Kamba, Keisuke; Nagata, Takashi; Katahira, Masato

    2016-01-01

    Human APOBEC3G (A3G) is an antiviral factor that inactivates HIV. The C-terminal domain of A3G (A3G-CTD) deaminates cytosines into uracils within single-stranded DNA (ssDNA), which is reverse-transcribed from the viral RNA genome. The deaminase activity of A3G is highly sequence-specific; the third position (underlined) of a triplet cytosine (CCC) hotspot is converted into CCU. A3G deaminates a CCC that is located close to the 5′ end of ssDNA more effectively than ones that are less close to the 5′ end, so-called 3′ → 5′ polarity. We had developed an NMR method that can be used to analyze the deamination reaction in real-time. Using this method, we previously showed that 3′ → 5′ polarity can be explained rationally by A3G-CTD's nonspecific ssDNA-binding and sliding direction-dependent deamination activities. We then demonstrated that the phosphate backbone is important for A3G-CTD to slide on the ssDNA and to exert the 3′ → 5′ polarity, probably due to an electrostatic intermolecular interaction. In this study, we investigate the pH effects on the structure, deaminase activity, and 3′ → 5′ polarity of A3G-CTD. Firstly, A3G-CTD was shown to retain the native structure in the pH range of 4.0–10.5 by CD spectroscopy. Next, deamination assaying involving real-time NMR spectroscopy for 10-mer ssDNA containing a single CCC revealed that A3G-CTD's deaminase activity decreases as the pH increases in the range of pH 6.5–12.7. This is explained by destabilization of the complex between A3G-CTD and ssDNA due to the weakened electrostatic interaction with the increase in pH. Finally, deamination assaying for 38-mer ssDNA having two CCC hotspots connected by a long poly-adenine linker showed that A3G-CTD retains the same pH deaminase activity preference toward each CCC as that toward the CCC of the 10-mer DNA. Importantly, the 3′ → 5′ polarity turned out to increase as the pH decreases in the range of 6.5–8.0. This suggests that A3G

  6. Flight evaluation of advanced third-generation midwave infrared sensor

    NASA Astrophysics Data System (ADS)

    Shen, Chyau N.; Donn, Matthew

    1998-08-01

    In FY-97 the Counter Drug Optical Upgrade (CDOU) demonstration program was initiated by the Program Executive Office for Counter Drug to increase the detection and classification ranges of P-3 counter drug aircraft by using advanced staring infrared sensors. The demonstration hardware is a `pin-for-pin' replacement of the AAS-36 Infrared Detection Set (IRDS) located under the nose radome of a P-3 aircraft. The hardware consists of a 3rd generation mid-wave infrared (MWIR) sensor integrated into a three axis-stabilized turret. The sensor, when installed on the P- 3, has a hemispheric field of regard and analysis has shown it will be capable of detecting and classifying Suspected Drug Trafficking Aircraft and Vessels at ranges several factors over the current IRDS. This paper will discuss the CDOU system and it's lab, ground, and flight evaluation results. Test targets included target templates, range targets, dedicated target boats, and targets of opportunity at the Naval Air Warfare Center Aircraft Division and at operational test sites. The objectives of these tests were to: (1) Validate the integration concept of the CDOU package into the P-3 aircraft. (2) Validate the end-to-end functionality of the system, including sensor/turret controls and recording of imagery during flight. (3) Evaluate the system sensitivity and resolution on a set of verified resolution targets templates. (4) Validate the ability of the 3rd generation MWIR sensor to detect and classify targets at a significantly increased range.

  7. A multi-wavelength census of star formation activity in the young embedded cluster around Serpens/G3-G6

    NASA Astrophysics Data System (ADS)

    Djupvik, A. A.; André, Ph.; Bontemps, S.; Motte, F.; Olofsson, G.; Gålfalk, M.; Florén, H.-G.

    2006-11-01

    Aims.The aim of this paper is to characterise the star formation activity in the poorly studied embedded cluster Serpens/G3-G6, located ~45 arcmin (3 pc) to the south of the Serpens Cloud Core, and to determine the luminosity and mass functions of its population of Young Stellar Objects (YSOs). Methods: .Multi-wavelength broadband photometry was obtained to sample the near and mid-IR spectral energy distributions to separate YSOs from field stars and classify the YSO evolutionary stage. ISOCAM mapping in the two filters LW2 (5-8.5 μm) and LW3 (12-18 μm) of a 19 arcmin × 16 arcmin field was combined with JHKS data from 2MASS, KS data from Arnica/NOT, and L arcmin data from SIRCA/NOT. Continuum emission at 1.3 mm (IRAM) and 3.6 cm (VLA) was mapped to study the cloud structure and the coldest/youngest sources. Deep narrow band imaging at the 2.12 μm S(1) line of H2 from NOTCam/NOT was obtained to search for signs of bipolar outflows. Results: .We have strong evidence for a stellar population of 31 Class II sources, 5 flat-spectrum sources, 5 Class I sources, and two Class 0 sources. Our method does not sample the Class III sources. The cloud is composed of two main dense clumps aligned along a ridge over ~0.5 pc plus a starless core coinciding with absorption features seen in the ISOCAM maps. We find two S-shaped bipolar collimated flows embedded in the NE clump, and propose the two driving sources to be a Class 0 candidate (MMS3) and a double Class I (MMS2). For the Class II population we find a best age of ~2 Myr and compatibility with recent Initial Mass Functions (IMFs) by comparing the observed Class II luminosity function (LF), which is complete to 0.08 L⊙, to various model LFs with different star formation scenarios and input IMFs.

  8. Concepts for the Measurements Subsystems of the Third Generation Attributes Measurement System

    SciTech Connect

    Warren, Glen A.; Archer, Daniel E.; Cunningham, Mark; McConchie, Seth; Thron, Jonathon

    2012-07-20

    Abstract The 3rd Generation Attribute Measurement System project has been tasked by the U.S. National Nuclear Security Administration Office of Nuclear Verification to develop the next generation of attribute measurement system for potential verification applications. The primary improvements of this effort, compared to previous attribute measurement systems, are to address authentication and certification concerns throughout the design and development process and to conduct attribute measurements for highly enriched uranium and high explosives in addition to plutonium. This paper will present attribute measurement techniques under consideration by the project.

  9. Generation IV reactors and the ASTRID prototype: Lessons from the Fukushima accident

    NASA Astrophysics Data System (ADS)

    Gauché, François

    2012-05-01

    In France, the ASTRID prototype is a sodium-cooled fast neutron industrial demonstrator, fulfilling the criteria for Generation IV reactors. ASTRID will meet safety requirements as stringent as for 3rd generation reactors, and take into account lessons from the Fukushima accident. The objectives are to reinforce the robustness of the safety demonstration for all safety functions. ASTRID will feature an innovative core with a negative sodium void coefficient, take advantage of the large thermal inertia of SFRs for decay heat removal, and provide for a design either eliminating the sodium-water reaction, or guaranteeing no consequences for safety in case such reaction would take place.

  10. Assessment of the toxicity of a pesticide with a two-generation reproduction test using Daphnia magna.

    PubMed

    Sánchez, M; Ferrando, M D; Sancho, E; Andreu, E

    1999-11-01

    Daphnia magna (F0 generation) were exposed during 21 days to different diazinon concentrations. Offspring (animals from the first and third brood: F1 (1st) and F1 (3rd), respectively) were transferred to a free pesticide medium during a 21-day recovery period. The algae Nannochloris oculata (5x10(5) cells/ml) were used as food. In this recovery study, survival, growth and reproduction (mean total young per female, mean brood size, onset of reproduction and mean number broods per female) were assessed as individual parameters, and the intrinsic rate of natural increase (r) as population parameter for F1 (1st and 3rd broods) daphnids. Reproduction as well as survival was still reduced in F1 (1st) generation daphnids from parentals (F0) exposed to the highest diazinon concentration. However, F1 (1st) and F1 (3rd) individuals from parentals exposed to pesticide concentrations below 0.5 ng/l were able to restore reproduction and survival when a recovery period of 21 days was allowed. PMID:10661716

  11. Draft Genome Sequences of Pseudomonas fluorescens Strains PA4C2 and PA3G8 and Pseudomonas putida PA14H7, Three Biocontrol Bacteria against Dickeya Phytopathogens

    PubMed Central

    Cigna, Jérémy; Raoul des Essarts, Yannick; Mondy, Samuel; Hélias, Valérie; Beury-Cirou, Amélie

    2015-01-01

    Pseudomonas fluorescens strains PA4C2 and PA3G8 and Pseudomonas putida strain PA14H7 were isolated from potato rhizosphere and show an ability to inhibit the growth of Dickeya phytopathogens. Here, we report their draft genome sequences, which provide a basis for understanding the molecular mechanisms involved in antibiosis against Dickeya. PMID:25635023

  12. ISSR-PCR DNA fingerprinting uncovers distinct banding patterns in Gonatocerus species 3(G.sp.3) individuals emerging from different host tribes: A prospective egg parasitoid candidate agent for the glassy-winged sharpshooter.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We started work to genetically characterize a prospective glassy-winged sharsphooter (GWSS), Homalodisca vitripennis (Germar) [=H. coagulata (Say)] egg parasitoid biological control candidate agent from South America known as Gonatocerus species 3 (G. sp. 3). This species is morphologically very si...

  13. Smile--the next generation of laser vision correction.

    PubMed

    Miruna, Nicolae; Andrei, Filip; Vasile, Filip Mircea; Rotaru, Eugen

    2016-01-01

    Our paper is an introduction in this new generation of Laser vision correction, called SMILE. It also reveals our experience in the past year, since we started to perform this new procedure in our patients. Small Incision Lenticule Extraction technique is the 3rd generation of Laser vision correction that completely redefines refractive surgery. Being performed entirely with femtosecond laser, SMILE is tissue preserving and very gentle for the eye. In 2011, it was launched internationally. We have started with SMILE in October 2014. Since then, we have performed more than 200 procedures, with the range of corrected diopters between -2 and -10 and astigmatism between -2 and -5. In the near future, hyperopic diopters will be corrected with SMILE. PMID:27220224

  14. Generational diversity.

    PubMed

    Kramer, Linda W

    2010-01-01

    Generational diversity has proven challenges for nurse leaders, and generational values may influence ideas about work and career planning. This article discusses generational gaps, influencing factors and support, and the various generational groups present in today's workplace as well as the consequences of need addressing these issues. The article ends with a discussion of possible solutions. PMID:20395729

  15. Three Generations of Tracking and Data Relay Satellite (TDRS) Spacecraft

    NASA Technical Reports Server (NTRS)

    Zaleski, Ron

    2016-01-01

    The current Tracking and Data Relay Satellite configuration consists of nine in-orbit satellites (four first generation, three second generation and two third generation satellites) globally distributed in geosynchronous orbit to provide near continuous data relay service to missions like Hubble Space Telescope and the International Space Station. The 1st generation spacecraft were designed by TRW/Northrop Grumman with their launches of the five spacecraft ranging from 1983 through 1995. The 2nd and 3rd generation spacecraft were designed by Boeing with their launches ranging 2000 - 2002 and 2013 - 2017 respectively. TDRS-3 is now 27 years on orbit, continues to be a capable asset for the TDRS constellation. Lack of need for inclination control combined with large fuel reserves and redundancy on critical elements provides spacecraft that operate well past design life, all of which contributes to expanded TDRS constellation support capabilities. All spacecraft generations have issues. Significant issues will be summarized with the focus on the Boeing related problems. Degradations and failures are continually assessed and provide the foundation for yearly updates to spacecraft reliability models, constellation service projections and deorbit plans (in order to meet NASAs mandate of limiting orbital debris). Even when accounting for degradations and failures, the life expectancy for the Boeing delivered 2nd generation TDRS-8, 9 10 TDRS are anticipated to be 25+ years.

  16. Third-generation naval IRST using the step-and-stare architecture

    NASA Astrophysics Data System (ADS)

    Nouguès, Pierre-Olivier; Baize, Paul; Roland, Flavien; Olivier, Jean-François; Renaudat, Mathieu

    2008-04-01

    With large focal plane arrays now widely available, IR detectors have entered their third generation. Performances have increased dramatically with respect to second-generation, line array detectors, due to the longer integration times afforded. For surveillance systems such as InfraRed Search and Track (IRST), however, operational requirements generally impose a very large field of regard in relation to the instantaneous field of view. This characteristic which has traditionally been obtained through scanning motion for second generation line array detectors must now be rethought to obtain staring operation for 3rd generation FPA, lest motion blurring be incurred. This paper presents several approaches considered for naval surveillance systems at Sagem Defense Securite to tackle this challenge. Three techniques are presented and then compared: fully staring systems, step-and-stare systems, and finally a "modified" step-and-stare system.

  17. Wind Generators

    NASA Technical Reports Server (NTRS)

    1989-01-01

    When Enerpro, Inc. president, Frank J. Bourbeau, attempted to file a patent on a system for synchronizing a wind generator to the electric utility grid, he discovered Marshall Space Flight Center's Frank Nola's power factor controller. Bourbeau advanced the technology and received a NASA license and a patent for his Auto Synchronous Controller (ASC). The ASC reduces generator "inrush current," which occurs when large generators are abruptly brought on line. It controls voltage so the generator is smoothly connected to the utility grid when it reaches its synchronous speed, protecting the components from inrush current damage. Generator efficiency is also increased in light winds by applying lower than rated voltage. Wind energy is utilized to drive turbines to generate electricity for utility companies.

  18. Translation Initiation on mRNAs Bound by Nuclear Cap-binding Protein Complex CBP80/20 Requires Interaction between CBP80/20-dependent Translation Initiation Factor and Eukaryotic Translation Initiation Factor 3g*

    PubMed Central

    Choe, Junho; Oh, Nara; Park, Sungjin; Lee, Ye Kyung; Song, Ok-Kyu; Locker, Nicolas; Chi, Sung-Gil; Kim, Yoon Ki

    2012-01-01

    In the cytoplasm of mammalian cells, either cap-binding proteins 80 and 20 (CBP80/20) or eukaryotic translation initiation factor (eIF) 4E can direct the initiation of translation. Although the recruitment of ribosomes to mRNAs during eIF4E-dependent translation (ET) is well characterized, the molecular mechanism for CBP80/20-dependent translation (CT) remains obscure. Here, we show that CBP80/20-dependent translation initiation factor (CTIF), which has been shown to be preferentially involved in CT but not ET, specifically interacts with eIF3g, a component of the eIF3 complex involved in ribosome recruitment. By interacting with eIF3g, CTIF serves as an adaptor protein to bridge the CBP80/20 and the eIF3 complex, leading to efficient ribosome recruitment during CT. Accordingly, down-regulation of CTIF using a small interfering RNA causes a redistribution of CBP80 from polysome fractions to subpolysome fractions, without significant consequence to eIF4E distribution. In addition, down-regulation of eIF3g inhibits the efficiency of nonsense-mediated mRNA decay, which is tightly coupled to CT but not to ET. Moreover, the artificial tethering of CTIF to an intercistronic region of dicistronic mRNA results in translation of the downstream cistron in an eIF3-dependent manner. These findings support the idea that CT mechanistically differs from ET. PMID:22493286

  19. Generation of UV light by intense ultrashort laser pulses in air

    NASA Astrophysics Data System (ADS)

    Alexeev, Ilya; Ting, Antonio; Gordon, Daniel; Briscoe, Eldridge; Penano, Joe; Sprangle, Phillip

    2004-11-01

    The propagation of collimated high-peak-power ultrashort laser pulses in air has attracted considerable attention, which may have a variety of important applications including remote sensing and chemical-biological aerosols standoff detection. Sub-millimeter diameter laser filaments can develop without any focusing optics and instead solely from laser self-focusing and plasma formation in air. These filaments can produce ultraviolet radiations in the form of the 3rd harmonic of the fundamental frequency and also through spectral broadening due to self-phase modulation of the laser pulse. Using femtosecond laser pulses produced by a high power Ti:Sapphire laser (0.8 TW, 50 fs, 800 nm) we observed generation of the third harmonic radiation light in air (centered around 267 nm) by the laser filaments. Characterization of the 3rd harmonic generation with respect to the major gas components of the air will be reported. Supported by the ONR and RDECOM. I. Alexeev is NRC/NRL Post-Doc.

  20. Generative Semantics

    ERIC Educational Resources Information Center

    Bagha, Karim Nazari

    2011-01-01

    Generative semantics is (or perhaps was) a research program within linguistics, initiated by the work of George Lakoff, John R. Ross, Paul Postal and later McCawley. The approach developed out of transformational generative grammar in the mid 1960s, but stood largely in opposition to work by Noam Chomsky and his students. The nature and genesis of…

  1. Parental Socioeconomic Status, Communication, and Children's Vocabulary Development: A Third-Generation Test of the Family Investment Model

    ERIC Educational Resources Information Center

    Sohr-Preston, Sara L.; Scaramella, Laura V.; Martin, Monica J.; Neppl, Tricia K.; Ontai, Lenna; Conger, Rand

    2013-01-01

    This third-generation, longitudinal study evaluated a family investment perspective on family socioeconomic status (SES), parental investments in children, and child development. The theoretical framework was tested for first-generation parents (G1), their children (G2), and the children of the second generation (G3). G1 SES was expected to…

  2. The perimeter generating functions of three-choice, imperfect, and one-punctured staircase polygons

    NASA Astrophysics Data System (ADS)

    Assis, M.; van Hoeij, M.; Maillard, J.-M.

    2016-05-01

    We consider the isotropic perimeter generating functions of three-choice, imperfect, and one-punctured staircase polygons, whose 8th order linear Fuchsian ODEs are previously known. We derive simple relationships between the three generating functions, and show that all three generating functions are joint solutions of a common 12th order Fuchsian linear ODE. We find that the 8th order differential operators can each be rewritten as a direct sum of a direct product, with operators no larger than 3rd order. We give closed-form expressions for all the solutions of these operators in terms of 2 F 1 hypergeometric functions with rational and algebraic arguments. The solutions of these linear differential operators can in fact be expressed in terms of two modular forms, since these 2 F 1 hypergeometric functions can be expressed with two, rational or algebraic, pullbacks. Dedicated to A J Guttmann on the occasion of his 70th birthday.

  3. Microstructure Modeling of Third Generation Disk Alloys

    NASA Technical Reports Server (NTRS)

    Jou, Herng-Jeng

    2010-01-01

    The objective of this program was to model, validate, and predict the precipitation microstructure evolution, using PrecipiCalc (QuesTek Innovations LLC) software, for 3rd generation Ni-based gas turbine disc superalloys during processing and service, with a set of logical and consistent experiments and characterizations. Furthermore, within this program, the originally research-oriented microstructure simulation tool was to be further improved and implemented to be a useful and user-friendly engineering tool. In this report, the key accomplishments achieved during the third year (2009) of the program are summarized. The activities of this year included: Further development of multistep precipitation simulation framework for gamma prime microstructure evolution during heat treatment; Calibration and validation of gamma prime microstructure modeling with supersolvus heat treated LSHR; Modeling of the microstructure evolution of the minor phases, particularly carbides, during isothermal aging, representing the long term microstructure stability during thermal exposure; and the implementation of software tools. During the research and development efforts to extend the precipitation microstructure modeling and prediction capability in this 3-year program, we identified a hurdle, related to slow gamma prime coarsening rate, with no satisfactory scientific explanation currently available. It is desirable to raise this issue to the Ni-based superalloys research community, with hope that in future there will be a mechanistic understanding and physics-based treatment to overcome the hurdle. In the mean time, an empirical correction factor was developed in this modeling effort to capture the experimental observations.

  4. Energy generator

    SciTech Connect

    Krisko, P.

    1989-08-01

    The patent describes a power booster. It comprises: at least one pendulum means suspended at one end to oscillate about the point of suspension; power generating means; mass means connected to one end of the pendulum means; spring means disposed in operative cooperation with the mass means to impart energy into the pendulum means and assist the pendulum means in oscillating about the point of suspension; and energy transfer linkage means between the pendulum means and the power generating means for transferring energy between the pendulum means and the power generating means.

  5. Generation Wrecked.

    ERIC Educational Resources Information Center

    Watson, Noshua

    2002-01-01

    Young adults in Generation X are facing financial problems. Because of their college and credit card debt, many in worse financial shape than anyone since the Depression and have little or no retirement savings. (JOW)

  6. Thermoelectric Generator

    NASA Technical Reports Server (NTRS)

    Cole, T.

    1985-01-01

    Small modular alkali metal thermoelectric generator with no moving parts directly converts heat to electrical energy with efficiency of 20 to 40 percent. Unit uses closed regenerative electrochemical concentration cell based on sodium-ion conductor beta alumina.

  7. Mesh generation

    NASA Astrophysics Data System (ADS)

    Ecer, A.

    1987-05-01

    Computational grids for complex three dimensional flow geometries, and a finite element grid generation scheme based on multiple block structures are introduced. The procedure can handle arbitrary geometries and is not restricted to modeling single shapes.

  8. Vibration generators

    SciTech Connect

    Lerwill, W.E.

    1980-09-16

    Apparatus for generating vibrations in a medium, such as the ground, comprises a first member which contacts the medium, means , preferably electromagnetic, which includes two relatively movable members for generating vibrations in the apparatus and means operatively connecting the said two members to said first member such that the relatively amplitudes of the movements of said three members can be adjusted to match the impedances of the apparatus and the medium.

  9. Third generation infrared system calibration using dual band thermoelectric thermal reference sources and test systems to calibrate uncooled IRFPAs

    NASA Astrophysics Data System (ADS)

    Finfrock, David K.; Kolander, William L.

    2008-04-01

    As dual band, 3rd generation FLIR systems progress from the research lab into the field, supporting technologies must also advance. This paper describes advances in Thermoelectric Thermal Reference Sources (TTRS) from single band (3 to 5 or 8 to 12 microns) to dual band in one assembly (3 to 5 and 8 to 12 microns). It will describe the optical, system, electrical, and mechanical parameters of dual band TTRS units. It provides IR system design engineers with the critical parameters of dual band TTRS units to aid in their design process. TTRS assemblies provide a temperature controllable radiometrically uniform surface. When viewed by theFLIR system detectors, the TTRS enables the system electronics to perform gain and offset calibration as well as DC restoration for each pixel's preamp Some of the parameters for 3rd Generation FLIR system TTRS units included in this paper will be: Emissivity of BB surfaces. Apparent thermal radiometric uniformity. How this is predicted and measured. Window material wavelength transmission (Hermetically sealed units only). TTRS emitter surface temperatures as a function of heat sink temperatures. Trade-off between uniformity, power consumption, and transient performance. Power consumption, Thermal interfaces and required heat sinking Types and accuracy of Temperature sensors mounted on emitter surface. Also included in this paper is a description of a Thermoelectric Black Body Test Apparatus that can be used to generate temperature coefficients needed to "burn" Proms for uncooled IRFPAs during their production and burn in processing.

  10. High-Pitch CT Pulmonary Angiography in Third Generation Dual-Source CT: Image Quality in an Unselected Patient Population

    PubMed Central

    Sabel, Bastian O.; Buric, Kristijan; Karara, Nora; Thierfelder, Kolja M.; Dinkel, Julien; Sommer, Wieland H.; Meinel, Felix G.

    2016-01-01

    Objectives To investigate the feasibility of high-pitch CT pulmonary angiography (CTPA) in 3rd generation dual-source CT (DSCT) in unselected patients. Methods Forty-seven patients with suspected pulmonary embolism underwent high-pitch CTPA on a 3rd generation dual-source CT scanner. CT dose index (CTDIvol) and dose length product (DLP) were obtained. Objective image quality was analyzed by calculating signal-to-noise-ratio (SNR) and contrast-to-noise ratio (CNR). Subjective image quality on the central, lobar, segmental and subsegmental level was rated by two experienced radiologists. Results Median CTDI was 8.1 mGy and median DLP was 274 mGy*cm. Median SNR was 32.9 in the central and 31.9 in the segmental pulmonary arteries. CNR was 29.2 in the central and 28.2 in the segmental pulmonary arteries. Median image quality was “excellent” in central and lobar arteries and “good” in subsegmental arteries according to both readers. Segmental arteries varied between “excellent” and “good”. Image quality was non-diagnostic in one case (2%), beginning in the lobar arteries. Thirteen patients (28%) showed minor motion artifacts. Conclusions In third-generation dual-source CT, high-pitch CTPA is feasible for unselected patients. It yields excellent image quality with minimal motion artifacts. However, compared to standard-pitch cohorts, no distinct decrease in radiation dose was observed. PMID:26872262

  11. Microwave generator

    SciTech Connect

    Kwan, T.J.T.; Snell, C.M.

    1987-03-31

    A microwave generator is provided for generating microwaves substantially from virtual cathode oscillation. Electrons are emitted from a cathode and accelerated to an anode which is spaced apart from the cathode. The anode has an annular slit there through effective to form the virtual cathode. The anode is at least one range thickness relative to electrons reflecting from the virtual cathode. A magnet is provided to produce an optimum magnetic field having the field strength effective to form an annular beam from the emitted electrons in substantial alignment with the annular anode slit. The magnetic field, however, does permit the reflected electrons to axially diverge from the annular beam. The reflected electrons are absorbed by the anode in returning to the real cathode, such that substantially no reflexing electrons occur. The resulting microwaves are produced with a single dominant mode and are substantially monochromatic relative to conventional virtual cathode microwave generators. 6 figs.

  12. Hydrogen Generator

    NASA Technical Reports Server (NTRS)

    1978-01-01

    Another spinoff from spacecraft fuel cell technology is the portable hydrogen generator shown. Developed by General Electric Company, it is an aid to safer operation of systems that use hydrogen-for example, gas chromatographs, used in laboratory analysis of gases. or flame ionization detectors used as $ollution monitors. The generator eliminates the need for high-pressure hydrogen storage bottles, which can be a safety hazard, in laboratories, hospitals and industrial plants. The unit supplies high-purity hydrogen by means of an electrochemical process which separates the hydrogen and oxygen in distilled water. The oxygen is vented away and the hydrogen gas is stored within the unit for use as needed. GE's Aircraft Equipment Division is producing about 1,000 of the generators annually.

  13. PULSE GENERATOR

    DOEpatents

    Roeschke, C.W.

    1957-09-24

    An improvement in pulse generators is described by which there are produced pulses of a duration from about 1 to 10 microseconds with a truly flat top and extremely rapid rise and fall. The pulses are produced by triggering from a separate input or by modifying the current to operate as a free-running pulse generator. In its broad aspect, the disclosed pulse generator comprises a first tube with an anode capacitor and grid circuit which controls the firing; a second tube series connected in the cathode circuit of the first tube such that discharge of the first tube places a voltage across it as the leading edge of the desired pulse; and an integrator circuit from the plate across the grid of the second tube to control the discharge time of the second tube, determining the pulse length.

  14. Generation Next

    ERIC Educational Resources Information Center

    Hawkins, B. Denise

    2010-01-01

    There is a shortage of accounting professors with Ph.D.s who can prepare the next generation. To help reverse the faculty deficit, the American Institute of Certified Public Accountants (CPAs) has created the new Accounting Doctoral Scholars program by pooling more than $17 million and soliciting commitments from more than 70 of the nation's…

  15. PreK-3rd: Raising the Educational Performance of English Language Learners (ELLs). PreK-3rd Policy to Action Brief. No. Six

    ERIC Educational Resources Information Center

    Russakoff, Dale

    2011-01-01

    In 1974, the United States Supreme Court ruled in "Lau v. Nichols" that 1,800 Chinese-speaking children in the San Francisco public schools were entitled to English-language instruction or other support to help them understand what was happening in their classrooms. Thirty-six years later, state and local responsibilities to public school children…

  16. Magnetocumulative generator

    DOEpatents

    Pettibone, J.S.; Wheeler, P.C.

    1981-06-08

    An improved magnetocumulative generator is described that is useful for producing magnetic fields of very high energy content over large spatial volumes. The polar directed pleated magnetocumulative generator has a housing providing a housing chamber with an electrically conducting surface. The chamber forms a coaxial system having a small radius portion and a large radius portion. When a magnetic field is injected into the chamber, from an external source, most of the magnetic flux associated therewith positions itself in the small radius portion. The propagation of an explosive detonation through high-explosive layers disposed adjacent to the housing causes a phased closure of the chamber which sweeps most of the magnetic flux into the large radius portion of the coaxial system. The energy content of the magnetic field is greatly increased by flux stretching as well as by flux compression. The energy enhanced magnetic field is utilized within the housing chamber itself.

  17. Thermoelectric generator

    DOEpatents

    Pryslak, N.E.

    1974-02-26

    A thermoelectric generator having a rigid coupling or stack'' between the heat source and the hot strap joining the thermoelements is described. The stack includes a member of an insulating material, such as ceramic, for electrically isolating the thermoelements from the heat source, and a pair of members of a ductile material, such as gold, one each on each side of the insulating member, to absorb thermal differential expansion stresses in the stack. (Official Gazette)

  18. PLASMA GENERATOR

    DOEpatents

    Foster, J.S. Jr.

    1958-03-11

    This patent describes apparatus for producing an electricity neutral ionized gas discharge, termed a plasma, substantially free from contamination with neutral gas particles. The plasma generator of the present invention comprises a plasma chamber wherein gas introduced into the chamber is ionized by a radiofrequency source. A magnetic field is used to focus the plasma in line with an exit. This magnetic field cooperates with a differential pressure created across the exit to draw a uniform and uncontaminated plasma from the plasma chamber.

  19. Cluster generator

    DOEpatents

    Donchev, Todor I.; Petrov, Ivan G.

    2011-05-31

    Described herein is an apparatus and a method for producing atom clusters based on a gas discharge within a hollow cathode. The hollow cathode includes one or more walls. The one or more walls define a sputtering chamber within the hollow cathode and include a material to be sputtered. A hollow anode is positioned at an end of the sputtering chamber, and atom clusters are formed when a gas discharge is generated between the hollow anode and the hollow cathode.

  20. Photon generator

    DOEpatents

    Srinivasan-Rao, Triveni

    2002-01-01

    A photon generator includes an electron gun for emitting an electron beam, a laser for emitting a laser beam, and an interaction ring wherein the laser beam repetitively collides with the electron beam for emitting a high energy photon beam therefrom in the exemplary form of x-rays. The interaction ring is a closed loop, sized and configured for circulating the electron beam with a period substantially equal to the period of the laser beam pulses for effecting repetitive collisions.

  1. Electric generator

    DOEpatents

    Foster, Jr., John S.; Wilson, James R.; McDonald, Jr., Charles A.

    1983-01-01

    1. In an electrical energy generator, the combination comprising a first elongated annular electrical current conductor having at least one bare surface extending longitudinally and facing radially inwards therein, a second elongated annular electrical current conductor disposed coaxially within said first conductor and having an outer bare surface area extending longitudinally and facing said bare surface of said first conductor, the contiguous coaxial areas of said first and second conductors defining an inductive element, means for applying an electrical current to at least one of said conductors for generating a magnetic field encompassing said inductive element, and explosive charge means disposed concentrically with respect to said conductors including at least the area of said inductive element, said explosive charge means including means disposed to initiate an explosive wave front in said explosive advancing longitudinally along said inductive element, said wave front being effective to progressively deform at least one of said conductors to bring said bare surfaces thereof into electrically conductive contact to progressively reduce the inductance of the inductive element defined by said conductors and transferring explosive energy to said magnetic field effective to generate an electrical potential between undeformed portions of said conductors ahead of said explosive wave front.

  2. Evaluation of Forces Generated on Three Different Rotary File Systems in Apical Third of Root Canal using Finite Element Analysis

    PubMed Central

    Medha, Ashish; Patil, Suvarna; Hoshing, Upendra; Bandekar, Siddhesh

    2014-01-01

    Aim: Aim of the study is to evaluate the distribution of forces on the instrument in the apical 3rd of curved canal with three Nickel Titanium rotary systems. Methodology: Three brands of instruments (ProTaper Universal; DENTSPLY Maillefer, RevoS; MicroMega and Hyflex; Coltene-Whaledent, Allstetten, Switzerland) were scanned with the Laser assisted computerized scanner to produce a real-size, 3-dimensional (3-D) model for each. The stresses on the instrument during simulated shaping of a root canal were analyzed numerically by using a 3-D finite element package, taking into account the nonlinear mechanical behavior of the nickel-titanium material. Results: RevoS shows lowest values for force generation in the apical 3rd of canal as compared to Protaper which shows highest values, while Hyflex shows intermediate values for forces. Conclusion: With FE simulation of root canal shaping by 3 files, it was observed that different instrument designs would experience unequal degree of force generation in canal, as well as reaction torque from the root canal wall. PMID:24596786

  3. Heterogeneous reactions of HNO3(g) + NaCl(s) yields HCl(g) + NaNO3(s) and N2O5(g) + NaCl(s) yields ClNO2(g) + NaNO3(s)

    NASA Technical Reports Server (NTRS)

    Leu, Ming-Taun; Timonen, Raimo S.; Keyser, Leon F.; Yung, Yuk L.

    1995-01-01

    The heterogeneous reactions of HNO3(g) + NaCl(s) yields HCl(g) + NaNO3(s) (eq 1) and N2O5(g) + NaCl(s) yields ClNO2(g) + NaNO3(S) (eq 2) were investigated over the temperature range 223-296 K in a flow-tube reactor coupled to a quadrupole mass spectrometer. Either a chemical ionization mass spectrometer (CIMS) or an electron-impact ionization mass spectrometer (EIMS) was used to provide suitable detection sensitivity and selectivity. In order to mimic atmospheric conditions, partial pressures of HNO3 and N2O5 in the range 6 x 10(exp -8) - 2 x 10(exp -6) Torr were used. Granule sizes and surface roughness of the solid NaCl substrates were determined by using a scanning electron microscope. For dry NaCl substrates, decay rates of HNO3 were used to obtain gamma(1) = 0.013 +/- 0.004 (1sigma) at 296 K and > 0.008 at 223 K, respectively. The error quoted is the statistical error. After all corrections were made, the overall error, including systematic error, was estimated to be about a factor of 2. HCl was found to be the sole gas-phase product of reaction 1. The mechanism changed from heterogeneous reaction to predominantly physical adsorption when the reactor was cooled from 296 to 223 K. For reaction 2 using dry salts, gamma(2) was found to be less than 1.0 x 10(exp -4) at both 223 and 296 K. The gas-phase reaction product was identified as ClNO2 in previous studies using an infrared spectrometer. An enhancement in reaction probability was observed if water was not completely removed from salt surfaces, probably due to the reaction of N2O5(g) + H2O(s) yields 2HNO3(g). Our results are compared with previous literature values obtained using different experimental techniques and conditions. The implications of the present results for the enhancement of the hydrogen chloride column density in the lower stratosphere after the El Chichon volcanic eruption and for the chemistry of HCl and HNO3 in the marine troposphere are discussed.

  4. L-nucleotides and 8-methylguanine of d(C1m8G2C3G4C5LG6LC7G8C9G10)2 act cooperatively to promote a left-handed helix under physiological salt conditions

    PubMed Central

    Cherrak, Ilham; Mauffret, Olivier; Santamaria, Fanny; Hocquet, Alexandre; Ghomi, Mahmoud; Rayner, Bernard; Fermandjian, Serge

    2003-01-01

    The structure and thermal stability of a hetero chiral decaoligodeoxyribonucleotide duplex d(C1m8 G2C3G4C5LG6LC7G8C9G10)d(C11m8G12C13G14C15LG16LC17G18C19G20) (O1) with two contiguous pairs of enantiomeric 2′-deoxy-l-ribonucleotides (C5LG6L/C15LG16L) at its centre and an 8-methylguanine at position 2/12 was analysed by circular dichroism, NMR and molecular modelling. O1 resolves in a left-handed helical structure already at low salt concentration (0.1 M NaCl). The central l2-sugar portion assumes a B* left-handed conformation (mirror-image of right-handed B-DNA) while its flanking d4-sugar portions adopt the known Z left-handed conformation. The resulting Z4–B2*–Z4 structure (left-handed helix) is the reverse of that of B4–Z2*–B4 (right-handed helix) displayed by the nearly related decaoligodeoxyribonucleotide d(mC1G2mC3G4C5L G6LmC7G8mC9G10)2, at the same low salt concentration (0.1 M NaCl). In the same experimental conditions, d(C1m8G2C3G4C5G6C7G8C9G10)2 (O2), the stereoregular version of O1, resolves into a right-handed B-DNA helix. Thus, both the 8-methylguanine and the enantiomeric step CLpGL at the centre of the molecule are needed to induce left-handed helicity. Remarkably, in the various heterochiral decaoligodeoxyribonucleotides so far analysed by us, when the central CLpGL adopts the B* (respectively Z*) conformation, then the adjacent steps automatically resolves in the Z (respectively B) conformation. This allows a good optimisation of the base–base stackings and base–sugar van der Waals interactions at the ZB*/B*Z (respectively BZ*/Z*B) junctions so that the Z4–B2*–Z4 (respectively B4–Z2*–B4) helix displays a Tm (∼65°C) that is only 5°C lower than the one of its homochiral counterpart. Here we anticipate that a large variety of DNA helices can be generated at low salt concentration by manipulating internal factors such as sugar configuration, duplex length, nucleotide composition and base methylation. These helices can

  5. Piezoelectrostatic generator

    NASA Technical Reports Server (NTRS)

    Robertson, Glen A. (Inventor)

    1990-01-01

    A piezoelectrostatic generator includes a plurality of elongated piezoelectric elements having first and second ends, with the first ends fixedly mounted in a cylindrical housing and the second extending radially inwardly toward an axis. A shaft movable along the axis is connected to the inner ends of the elements to produce bending forces in piezoelectric strips within the elements. Each element includes a pair of strips mounted in surface contact and in electrical series to produce a potential upon bending. Electrodes spaced from the strips by a solid dielectric material act as capacitor plates to collect the potential charge.

  6. Tide generator

    SciTech Connect

    Feltenberger, B.D.

    1981-06-16

    A tidewater power system consisting of a high tide reservoir and a low tide reservoir. The high tide reservoir has an inlet adapted to be supported at high tide level and an outlet with a water wheel and generator between the outlet of the high tide reservoir and the low tide reservoir. The low tide reservoir has an outlet at the low tide level. The outlet from the high tide reservoir is adjustable to control the flow rate and the high tide reservoir can be closed at high tide to retain water for use over a period of time.

  7. HEAT GENERATION

    DOEpatents

    Imhoff, D.H.; Harker, W.H.

    1963-12-01

    Heat is generated by the utilization of high energy neutrons produced as by nuclear reactions between hydrogen isotopes in a blanket zone containing lithium, a neutron moderator, and uranium and/or thorium effective to achieve multtplicatton of the high energy neutron. The rnultiplied and moderated neutrons produced react further with lithium-6 to produce tritium in the blanket. Thermal neutron fissionable materials are also produced and consumed in situ in the blanket zone. The heat produced by the aggregate of the various nuclear reactions is then withdrawn from the blanket zone to be used or otherwise disposed externally. (AEC)

  8. Magnetocumulative generator

    DOEpatents

    Pettibone, Joseph S.; Wheeler, Paul C.

    1983-01-01

    An improved magnetocumulative generator is described that is useful for producing magnetic fields of very high energy content over large spatial volumes. The polar directed pleated magnetocumulative generator has a housing (100, 101, 102, 103, 104, 105) providing a housing chamber (106) with an electrically conducting surface. The chamber (106) forms a coaxial system having a small radius portion and a large radius portion. When a magnetic field is injected into the chamber (106), from an external source, most of the magnetic flux associated therewith positions itself in the small radius portion. The propagation of an explosive detonation through high-explosive layers (107, 108) disposed adjacent to the housing causes a phased closure of the chamber (106) which sweeps most of the magnetic flux into the large radius portion of the coaxial system. The energy content of the magnetic field is greatly increased by flux stretching as well as by flux compression. The energy enhanced magnetic field is utilized within the housing chamber itself.

  9. PLASMA GENERATOR

    DOEpatents

    Wilcox, J.M.; Baker, W.R.

    1963-09-17

    This invention is a magnetohydrodynamic device for generating a highly ionized ion-electron plasma at a region remote from electrodes and structural members, thus avoiding contamination of the plasma. The apparatus utilizes a closed, gas-filled, cylindrical housing in which an axially directed magnetic field is provided. At one end of the housing, a short cylindrical electrode is disposed coaxially around a short axial inner electrode. A radial electrical discharge is caused to occur between the inner and outer electrodes, creating a rotating hydromagnetic ionization wave that propagates aiong the magnetic field lines toward the opposite end of the housing. A shorting switch connected between the electrodes prevents the wave from striking the opposite end of the housing. (AEC)

  10. Triboelectric generator

    DOEpatents

    Wang, Zhong L; Fan, Fengru; Lin, Long; Zhu, Guang; Pan, Caofeng; Zhou, Yusheng

    2015-11-03

    A generator includes a thin first contact charging layer and a thin second contact charging layer. The thin first contact charging layer includes a first material that has a first rating on a triboelectric series. The thin first contact charging layer has a first side with a first conductive electrode applied thereto and an opposite second side. The thin second contact charging layer includes a second material that has a second rating on a triboelectric series that is more negative than the first rating. The thin first contact charging layer has a first side with a first conductive electrode applied thereto and an opposite second side. The thin second contact charging layer is disposed adjacent to the first contact charging layer so that the second side of the second contact charging layer is in contact with the second side of the first contact charging layer.

  11. Synthesis and biological activity of novel series of 4-methoxy, and 4,9-dimethoxy-5-substituted furo[2,3-g]-1,2,3-benzoxathiazine-7,7-dioxide derivatives

    PubMed Central

    El-Sawy, Eslam R.; Ebaid, Manal S.; Abo-Salem, Heba M.; El-Hallouty, Salwa; Kassem, Emad M.; Mandour, Adel H.

    2013-01-01

    A novel series of 4-methoxy, and 4,9-dimethoxy-5-substituted furo[2,3-g]-1,2,3-benzoxathiazine-7,7-dioxide derivatives 3a,b, 10a–g and 11a–g were prepared in good yields via the reaction of 4-methoxy (1a) and 4,7-dimethoxy-5-acetyl-6-hydroxybenzofurans (1b) and their α,β-unsaturated keto derivatives 6a–g and 7a–g with chlorosulfonyl isocyanate (CSI). On the other hand, N-chlorosulfonyl carbamate derivatives 4a,b, 12a,b and 13a,b were prepared and allowed to react with piperidine to give the corresponding N-piperidinosulfonyl carbamate derivatives 5a,b, 14a,b and 15a,b, respectively. Sixteen new target compounds 3a,b, 10a–g, and 11a–g were tested for their DPPH radical-scavenging, and in vitro antiproliferative activity against A-549, MCF7 and HCT-116 cancer cell lines. Compounds 10a, 11c, 11e, and 11g showed moderate DPPH radical-scavenging activity compared to ascorbic acid at 100 μg/mL. 4,9-Dimethoxy-5-substituted styrylfuro[3,2-g]-1,2,3-benzoxathiazine-7,7-dioxides 11a, 11b, and 11c were found to be highly active against A-549 and HCT-116 cancer cell lines with IC50 values ranging from 0.02 to 0.08 μmol/mL compared to doxorubicin with IC50 = 0.04 and 0.06 μmol/mL, respectively. PMID:25685501

  12. Joint Development of a Fourth Generation Single Crystal Superalloy

    NASA Technical Reports Server (NTRS)

    Walston, S.; Cetel, A.; MacKay, R.; OHara, K.; Duhl, D.; Dreshfield, R.

    2004-01-01

    A new, fourth generation, single crystal superalloy has been jointly developed by GE Aircraft Engines, Pratt & Whitney, and NASA. The focus of the effort was to develop a turbine airfoil alloy with long-term durability for use in the High Speed Civil Transport. In order to achieve adequate long-time strength improvements at moderate temperatures and retain good microstructural stability, it was necessary to make significant composition changes from 2nd and 3rd generation single crystal superalloys. These included lower chromium levels, higher cobalt and rhenium levels and the inclusion of a new alloying element, ruthenium. It was found that higher Co levels were beneficial to reducing both TCP precipitation and SRZ formation. Ruthenium caused the refractory elements to partition more strongly to the ' phase, which resulted in better overall alloy stability. The final alloy, EPM 102, had significant creep rupture and fatigue improvements over the baseline production alloys and had acceptable microstructural stability. The alloy is currently being engine tested and evaluated for advanced engine applications.

  13. Thermoelectric generator

    SciTech Connect

    Shakun, W.; Bearden, J.H.; Henderson, D.R.

    1988-03-29

    A thermoelectric generator unit is described comprising: a hot side heat exchanger including a plate having extruded retention posts projecting from one surface of the plate, and fins adapted for contact with a heating source. The fins are positioned between two of the retention posts. Retention rods are inserted between the retention posts and the base of the fins to retain the fin in thermal contact with the plate surface upon insertion of the retention rod between the engaging surface of the post and the corresponding fin. Thermoelectric semi-conductor modules are in thermal contact with the opposite side of the hot side heat exchanger plate from the contact with the fins. The modules are arranged in a grid pattern so that heat flow is directed into each of the modules from the hot side heat exchanger. The modules are connected electrically so as to combine their electrical output; and a cold side heat exchanger is in thermal contact with the modules acting as a heat sink on the opposite side of the module from the hot side heat exchanger plate so as to produce a thermal gradient across the modules.

  14. [Assessment of the impact of GMO of plant origin on rat progeny development in 3 generations].

    PubMed

    Tyshko, N V; Zhminchenko, V M; Pashorina, V A; Seliaskin, K E; Saprykin, V P; Utembaeva, N T; Tutel'ian, V A

    2011-01-01

    The publication presents the results of assessment of impact of genetically modified (GM) maize Liberty Link on prenatal and postnatal development of progeny of 3 generations of Wistar rats. A total of 630 adult animals and 2837 pups were used in the experiment. The animals were divided into 5 groups which got the diets with inclusion of maize: the animals of the experimental group got the diet with the GM-maize, animals of the control group - with near isogenic conventional analogue of the GM-maize, animals of the 1st, 2nd and 3rd reference groups - conventional varieties of maize ROSS 144 MV, ROSS 197 MVW, Dokuchayevskaya 250 MV respectively. The maize was included in the diet at maximum possible level not violating the balance of basic nutrients. Analysis of the data obtained during the study did not reveal any impact of GM-maize on rat progeny development. PMID:21574464

  15. Generation of XUV light by resonant frequency tripling in a two-wiggler FEL amplifier

    SciTech Connect

    Bonifacio, R.; de Salvo Souza, L.; Pierini, P. . Dipt. di Fisica Istituto Nazionale di Fisica Nucleare, Milan ); Scharlemann, E.T. )

    1989-01-01

    FEL operation at short wavelength is limited by electron beam quality, by the availability of mirrors for oscillators, and by the availability of input sources for FEL amplifiers. It is possible to use and FEL amplifier as a resonant frequency tripling device, generating light and strong bunching at the 3rd harmonic of a conventional input source in an initial section of wiggler, then using a second section of wiggler resonant at the tripled frequency to amplify the short wavelength light. Neither mirrors nor a short-wavelength input source are required, and some relaxation of electron beam quality appears to be possible. We illustrate the scheme with a one-dimensional model and then with NUTMEG simulations of an 80 nm FEL amplifier initiated by a 240 nm input signal, in which an efficiency of conversion of electron beam power to 80 nm light of nearly 10{sup -4} was obtained. 3 refs., 6 figs., 1 tab.

  16. Generation of XUV light by resonant frequency tripling in a two-wiggler FEL amplifier

    NASA Astrophysics Data System (ADS)

    Bonifacio, R.; Desalvosouza, L.; Pierini, P.; Scharlemann, E. T.

    FEL operation at short wavelength is limited by electron beam quality, by the availability of mirrors for oscillators, and by the availability of input sources for FEL amplifiers. It is possible to use and FEL amplifier as a resonant frequency tripling device, generating light and strong bunching at the 3rd harmonic of a conventional input source in an initial section of wiggler, then using a second section of wiggler resonant at the tripled frequency to amplify the short wavelength light. Neither mirrors nor a short-wavelength input source are required, and some relaxation of electron beam quality appears to be possible. We illustrate the scheme with a one-dimensional model and then with NUTMEG simulations of an 80 nm FEL amplifier initiated by a 240 nm input signal, in which an efficiency of conversion of electron beam power to 80 nm light of nearly 10(exp -4) was obtained.

  17. Saving the "Lost Generation"

    ERIC Educational Resources Information Center

    Beebe, Anthony E.

    2007-01-01

    Since the beginning of the American experience, labels have been used to describe generations. Among them are the "Puritan generation," the "greatest generation," the "baby boomer generation" and the "MTV generation." Today, people are creating a new generation--the "lost generation." The lost generation represents a large and growing population…

  18. Aerodynamic stability analysis of NASA J85-13/planar pressure pulse generator installation

    NASA Technical Reports Server (NTRS)

    Chung, K.; Hosny, W. M.; Steenken, W. G.

    1980-01-01

    A digital computer simulation model for the J85-13/Planar Pressure Pulse Generator (P3 G) test installation was developed by modifying an existing General Electric compression system model. This modification included the incorporation of a novel method for describing the unsteady blade lift force. This approach significantly enhanced the capability of the model to handle unsteady flows. In addition, the frequency response characteristics of the J85-13/P3G test installation were analyzed in support of selecting instrumentation locations to avoid standing wave nodes within the test apparatus and thus, low signal levels. The feasibility of employing explicit analytical expression for surge prediction was also studied.

  19. Kids at Hope: Every Child Can Succeed, No Exceptions! 3rd Edition

    ERIC Educational Resources Information Center

    Carlos, John P.; Miller, Rick

    2010-01-01

    "Kids at Hope" inspires, empowers, and transforms families, youth serving organizations and entire communities to create an environment where all children experience success. This book contains the following chapters: (1) The Visit Universal Truths I & II; (2) The Classroom (A Celebration of Success); (3) What Makes a Difference?; (4) No…

  20. Conference report on the 3rd international symposium on lithium application for fusion devices

    SciTech Connect

    Mazzitelli, G.; Hirooka, Y.; Hu, J. S.; Mirnov, S. V.; Nygren, R.; Shimada, M.; Ono, M.; Tabares, F. L.

    2015-01-14

    The third International Symposium on Lithium Application for Fusion Device (ISLA-2013) was held on 9–11 October 2013 at ENEA Frascati Centre with growing participation and interest from the community working on more general aspect of liquid metal research for fusion energy development. ISLA-2013 has been confirmed to be the largest and the most important meeting dedicated to liquid metal application for the magnetic fusion research. Overall, 45 presentation plus 5 posters were given, representing 28 institutions from 11 countries. The latest experimental results from nine magnetic fusion devices were presented in 16 presentations from NSTX (PPPL, USA), FTU (ENEA, Italy), T-11M (Trinity, RF), T-10 (Kurchatov Institute, RF), TJ-II (CIEMAT, Spain), EAST(ASIPP, China), HT-7 (ASIPP, China), RFX (Padova, Italy), KTM (NNC RK, Kazakhstan). Sessions were devoted to the following: (I) lithium in magnetic confinement experiments (facility overviews), (II) lithium in magnetic confinement experiments (topical issues), (III) special session on liquid lithium technology, (IV) lithium laboratory test stands, (V) Lithium theory/modelling/comments, (VI) innovative lithium applications and (VII) special Session on lithium-safety and lithium handling. There was a wide participation from the fusion technology communities, including IFMIF and TBM communities providing productive exchange with the physics oriented magnetic confinement liquid metal research groups. This international workshop will continue on a biennial basis (alternating with the Plasma–Surface Interactions (PSI) Conference) and the next workshop will be held at CIEMAT, Madrid, Spain, in 2015.